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<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPC9</accession>
    <name>A0A7D5UPC9_9HYPO</name>
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        <recommendedName>
            <fullName evidence="5">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g018710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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            <dbReference type="Proteomes" id="UP000510686"/>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPQ4</accession>
    <name>A0A7D5UPQ4_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="mbrn:26239049"/>
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    <dbReference type="Proteomes" id="UP000510686">
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    <dbReference type="InterPro" id="IPR024630">
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="97"/>
        </location>
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            <end position="382"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000259" key="2">
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            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI63754.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQM1</accession>
    <name>A0A7D5UQM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Citrate synthase</fullName>
        </recommendedName>
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    <gene>
        <name evidence="12" type="primary">mcsA</name>
        <name evidence="12" type="ORF">G6M90_00g000850</name>
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    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Also has citrate synthase activity using as substrates acetyl-CoA and oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the citrate synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI64414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014687497.2"/>
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    <dbReference type="KEGG" id="mbrn:26244356"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
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        <property type="component" value="Chromosome 1"/>
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    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
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    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
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        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
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    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056526"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="51900" checksum="E35FAB97CD34DB2C" modified="2021-02-10" version="1">MALNLRNSTRAFGSLKPLTRAALIGARGYATAEPDLKATLKEVIPAKRELLKKVKAHGSKTIGEVKVENTLGGMRGLKAMVWEGSVLDANEGIRFHGKTIKDCQKILPKGKTGTEMLPEAMFWLLLTGQVPSTNQIRVFSRELAEKAQIPEFVSKMLDNFPKDLHPMTQFAMAVSALNYESKFAKAYEAGMNKSDYWEPTFDDCVSLLAKLPTIAAKIYQNAYRGGGALPAEVDLEQDWSYNFAAMLGKGGKANENFQDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRWILQMKEAIPAGYTEQDVHDYLWSTLNSGRVVPGYGHAVLRKPDPRFEALMDYAAARPDIAQDPVFQLVEKNSRIAPEVLKKHGKTKNPYPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLIWDRALGLPIERPKSINLEGLLKQVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQU5</accession>
    <name>A0A7D5UQU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Importin subunit beta-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kap114</name>
        <name evidence="6" type="ORF">G6M90_00g016230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548905.1">
        <property type="nucleotide sequence ID" value="XM_014693419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQU5"/>
    <dbReference type="GeneID" id="26238349"/>
    <dbReference type="KEGG" id="mbrn:26238349"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1027" mass="113111" checksum="65B64A59258B66F8" modified="2021-02-10" version="1">MEEQLVQLLANIQLPDQGPRQQAEIELRHARTNPVFPVSLAKIASHASVSTGVRQAALTSLRQFIEGNWAIGDQDDEPIIPIDDDTRAILRQSLLDLALSQEEDRKVKISASYAVGKIAIHDFPEQWPNLLPTVLSTIPSGTDAQLHGALRVLGDLVEESLSEDQFFSMARDIAKTLTEVALNENRKPMLRALAISVFRSCFDLMNMVKDDHSQEVKAFAEELLAQWNPFFVSVLKSRLPEADVSTGTQPDSWNHIVALKLQVVKTLLRIRRVFPNLLLPQSTTFFSAVWEELNLLQTPHEELYIKTNAQGRLEDSDNLPYTLDFLILEELDFLNQCFRSPPVKAELDGHLQAHASAQDVPWMVEIMRMLVSYSRVTQEEEELWDIDCSLYLAEETSVTANYTARTAAGDLLIKMGEWFNEKAVDGLFGFTKSLFPGDGSLWRSQESALFLFTMLLSDFQDLSKTIPDAVASAYLELVDFTINKPDEPLLRARGYLVAGIIGRSFQTPLALLDRMVHAITNEESEVVQVACIKAVEGLINSGRVGADRQVPIITAIQSYMNEKDPAEMEEADELLVVLAETLRSTISLDTKIALSSDIQSTDLLFMLAKLGASNFQVTMIISEAFEDIVASLSDSASFSALCARTLPTLTGAFDVASVTEDNPLVTVATELLVVLAENGSEPLPAGFVATIFPKLNRLLMESEEGEVLRPGSEIVKWVLSHDHQQVFNWQDANGRSGLEVCLHIIDRLLGPSIEDNSASEVGGLAAELVEKAGQERLGPFLPQLLQAVANRLASAQAAAFIQSLILVFARLSLNGAQDVVEFLSQIQINGDSGLQVVMAKWLENSVSFAGYDEIRQNVIALSKLYALNDSRLAQIQVKGDLIVGADDGKIKTRSRAKQNPDQYTIVPAPLKIVKVLIEELASAAGAGAAASTAAAAVAAAEFDEDNDEDGWEDDDDTLDLSLAATKADLMTFMEGGPQRRPDDETHSYLTEFFVRCGRENIANFQEWYNMLSEDEKTRLNLVANSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQW3</accession>
    <name>A0A7D5UQW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g001950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542885.1">
        <property type="nucleotide sequence ID" value="XM_014687399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQW3"/>
    <dbReference type="GeneID" id="26244258"/>
    <dbReference type="KEGG" id="mbrn:26244258"/>
    <dbReference type="OrthoDB" id="4939931at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="560" mass="59927" checksum="06DFF0126BD903E6" modified="2021-02-10" version="1">MFGSSRSSVASFSGSFSGGRMLDSPPMSPCQSNQSGVAVEHQDQDFCRIRGLASQIDSCAKARVIALLAMEFLVFDGKLHGGRSNWACPFGDCKENFPDVKDLMWHVAGCSLSSGAKVYCNSCRKYDCFTLQGGNGAFCSASDNAVRAGACSPRKSKGLRKLTNIFSRSRPASAPSSPETRHTVIPSVASSRRASSIGYPPSPGPQELGSGPPHEMSDSPSRGVPDTAIDMIPELPTTPGPFGAGRLSPVSMSNISPMFSEGFTESPVENVNGESALQPWHMSSENKPASLQTITPNEVPSSWSTSLPTAYSDLDRGTGQASWNMAQQTSPQYPCGLGSFSSNPYTSMNMYRQISSPLYGSTTTPEDAVCDGTSFVHHKQRSSSWPRPQTSMTGQSGPSTLGLARNGCVVPRLGGDASTSRMAPDHSGAPPPASRRGGEVRQMPMHGLLPEASPSLSSRPDEADSGRCPHLECSFQSKGKPAKRAVYLKKHLATHLPQKVMCSGCGREFSRPDNLKTHQKNVCPGTRLSVHERQSRTLSRRAARAQEASAIKWTRVYGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR68</accession>
    <name>A0A7D5UR68_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g021590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548389.1">
        <property type="nucleotide sequence ID" value="XM_014692903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR68"/>
    <dbReference type="GeneID" id="26237833"/>
    <dbReference type="KEGG" id="mbrn:26237833"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="71"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="166"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="270"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="44199" checksum="14CA894843635B12" modified="2021-02-10" version="1">MPLASQLSNFFFAGSSASAGDSSSDEHVVGLAEPPRNAGIHTKHSPGRSSVIASDSGRTMKSEDIETEGRPPYLHAMIAGGIGGSTGDLLMHSLDTVKTRQQGDPNIPSKYTSLGRSYYTIWRQEGVRRGLYGGWIPALGGSFPGTVMFFGTYEWSKRFLIDHGLQHHLAYLSAGFLGDLAASVVYVPSEVLKTRLQLQGRYNNPHFRSGYNYRGTLDAARTIVRTEGASALFYGYKATLYRDLPFSALQFMFWEQFHAWARVYKQSREIGVPLELLTGAAAGGLAGVITCPLDVVKTRLQTQVNPSSDQVTKLKEVASSQKRHISTSSPSTHRPQPGAIALETSSVITGLKVIYRTEGLAGWFRGVGPRGVWTFIQSGCMLFLYQRLLHQLEVMMPAEKDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URJ8</accession>
    <name>A0A7D5URJ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547838.1">
        <property type="nucleotide sequence ID" value="XM_014692352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URJ8"/>
    <dbReference type="GeneID" id="26237282"/>
    <dbReference type="KEGG" id="mbrn:26237282"/>
    <dbReference type="OrthoDB" id="5150075at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="270"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="789" mass="88923" checksum="33F057C9D17179F2" modified="2021-02-10" version="1">MSDQSRLELINENPIRNGLDAFRALFTSICTSRNLPSTIDTLRQLGAEDLRNLALTLFTSLRNLPISGSLHSTSGSATLRSVLLRLITAAASDSFDFDRIKPLLEIAISDDTKDVQIWDFVSTAAAESTPPPRSIASSLQQTPWSQNTSSFVNSSEYRQNVDPVLKLELEHLYVGLPNFHKSFFGDIPELDMVSEAVFRKCIEGDSPLFKEGWSGWPAGAKESDVLTWIGGLISQLEAFADNRIPTSVARRKLLAQPKTPLEGSTGKRSMDIGFVDSDIIYKPDTTDSRYRWAHILVVGELKNNPKADIASVAWIDLARYAREVLAAQDTRRFVLGFTLCGSLMRIWEFDRLGGIASEQFDINKEEGGLQFVATILGFLRMNEEMLGFDPTIVTTSGQKYIEIERNGQTECLVIDEVIKRAPCIAGRATTCWKAHRNNDPHNPLVIKDSWQYVDRDEEGELLQEATEKDVTNVARYYHHETVRIRRTDDDVRNNVRKGLDVTKATNFQPKRTLPSNVGGTVSRISRKGRSSSSGVKRPSSETDAALPPSKRSYSASPTKPSLDVLSNRIHRRVILRDYGEPIYKASSRAALLDALEGCIEGHESLRKAGFLHRDISVNNLRVNEDKANPSWRAFLIDLDLAIREHRDEASGAMGKTGTRAFMAIGALLGEQHSFMHDLESFFWVLFWICIHYNGPDDSRTVQRFEKWNYVEMAELAELKKGQVSHEQDFIKTTSEYFTTLYTPLIPWVNKLRKVVFPNGRRWEMEDARLYLRMKNVLRDAITDPTVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US64</accession>
    <name>A0A7D5US64_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g000760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542992.2">
        <property type="nucleotide sequence ID" value="XM_014687506.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US64"/>
    <dbReference type="GeneID" id="26244365"/>
    <dbReference type="KEGG" id="mbrn:26244365"/>
    <dbReference type="OrthoDB" id="4938879at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="144"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="438" mass="51697" checksum="C295332A0E8EF05C" modified="2021-02-10" version="1">MSHIENVDGVVFDPNLTKPDVLVLQNLVADIREYQERDEQCQRRRDKEGSDKEKGQSHRDAATITALAALNDPKHALFEPTVFSQVDTGDIRLPLSIDAWIFRPYVRVARSIVRVETDVVMLTHLLLYFSTSVPSAMFLFWKFTWVHGLLHFIMQVSYMGTYTLMMHQHIHMRGILNKRLSILDSLFPYITDPLMGHTWNSYYYHHVKHHHVEGNGPDDLSSTIRYQRDNVLHFLHYTARFFFLIWLDLPLYFIRKGWPAFAIKAAFWELSWYTTLYTLYQYNPKATFTVFLLPLLLLRSGLMLGNWGQHAFVDHDEPSSDYRSSITLIDVPSNRYCFNDGYHTSHHLNPRRHWREHPVSFMKSKELYAVQKALVFHNIDYLMITVRLLMKDYRTLARCMIPIGEEQMSMSIEDRMALLRSHTQKFTEKEIQDKFKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT02</accession>
    <name>A0A7D5UT02_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g005170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542164.1">
        <property type="nucleotide sequence ID" value="XM_014686678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT02"/>
    <dbReference type="GeneID" id="26245195"/>
    <dbReference type="KEGG" id="mbrn:26245195"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAR1" evidence="2">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="35552" checksum="4196378A8010D963" modified="2021-02-10" version="1">MFGILEAAAVPHSGIFNTYEDLMLDLNRRMEREGYKIVKARSHRNKIGGGDVAGNEIVRCDLVCDRGGRPYKSTATKHKTHTKKTGCPWKAKAVNRKSVGGWVLTVFCNEHNHEAGTPEPPSVPEACEEDGTDADNEDEIHAGPRPDPETSAALRVAGVSDSTLRLTGDTFHHLKTDYRKMTQGDRLNALAQLQLRIAALYAVQNEDMQRQRRQEDQHQRHRAVDASRNTLSAQKYRARRHPRTQDEQQKQATNLPVEPELSLTEDLVHIGPNHTPDALMQGPHFQLTVPGSAMDSVEMPQYHGSSKRMRPYRTQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT36</accession>
    <name>A0A7D5UT36_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General amino acid permease AGP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AGP2_0</name>
        <name evidence="7" type="ORF">G6M90_00g006580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549849.1">
        <property type="nucleotide sequence ID" value="XM_014694363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT36"/>
    <dbReference type="GeneID" id="26239293"/>
    <dbReference type="KEGG" id="mbrn:26239293"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="131" mass="13789" checksum="AAABCEA89177470E" modified="2021-02-10" version="1">MGVIEDNAAGSAASLWVIGIENLGITGLPGLINATILLSGMSCGKGHLYSSSRTLYGLARDGQAPRSLVKCTESGVPVYFVALVSLITCITFLVTAILYFGCKVWRVTETVDSQTADLVSGKAEVDEECKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTC0</accession>
    <name>A0A7D5UTC0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase citA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">citA</name>
        <name evidence="4" type="ORF">G6M90_00g030910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539648.2">
        <property type="nucleotide sequence ID" value="XM_014684162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTC0"/>
    <dbReference type="GeneID" id="26247559"/>
    <dbReference type="KEGG" id="mbrn:26247559"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="267" mass="29216" checksum="B521B1BE7B6E4D28" modified="2021-02-10" version="1">MTVDDTLSLPRILCLHGGGVNGTVFRLQCRAIIAQLGHRFRFVFMDAPYTSRPHRDIVTVYGDFAPFYRWLAWSREEPGLPPWARAGDVMDACLAAMERDAGDGPWAAVLGFSQGAKVAASLLWAQQRADEVLGPGRARTAFRFAVLMAGSAPVLHLDLRLPPPPPHVASPDAFSTDFTDYPDPGAPPSGLHVLRLPTLHVHGLQDPGIQRHRCLLERYCMPATARLVEWDAGHRLPVKTADVKAVVTEVLRLARETGAIPPDVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUC7</accession>
    <name>A0A7D5UUC7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal biogenesis factor 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Pex19</name>
        <name evidence="2" type="ORF">G6M90_00g010890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549432.1">
        <property type="nucleotide sequence ID" value="XM_014693946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUC7"/>
    <dbReference type="GeneID" id="26238876"/>
    <dbReference type="KEGG" id="mbrn:26238876"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="337" mass="36026" checksum="04F06CB6F0868536" modified="2021-02-10" version="1">MDAKPVAPEEIKEGDVEVKATDSNAAAAGAPKPAATTEDVPDPDEDDLDDLDDMLDEFSTVKLEDGANKPTESSSAGPSTSTPKQGDAAPKESPAAEEEPFSEEDFAKQLQAGMADLLGELEQSPEMQQQFEDMFKQMAAASGDAAPGTGAAGSSSAKAGAPGTASEAPFQETIRRTMERMQASGDQATAAAATSSGDDFMSELLKQMSSGDLNGEGSEEEFSKMLMGMMEQLTNKDILFEPMKELDDKFPEWFEKNKSSTPAEDLKRYEEQRVLVREIVAKFEESSYSDSNASDREYIVDRMQKMQAAGSPPSDLVGDMASAQEAFGGADDQCNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUF0</accession>
    <name>A0A7D5UUF0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ipgm-1</name>
        <name evidence="19" type="ORF">G6M90_00g044560</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986305.1">
        <property type="nucleotide sequence ID" value="XM_066130352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUF0"/>
    <dbReference type="GeneID" id="26240352"/>
    <dbReference type="KEGG" id="mbrn:26240352"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="17">
        <location>
            <begin position="7"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="18">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="266"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="453"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
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        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="530" mass="58186" checksum="98539D8B3C727535" modified="2021-02-10" version="1">MSKTEQKACLIVIDGWGIPSEESPKDGDAIAAAKTPVMDELSNNAEGFTELDASSLAVGLPDGLMGNSEVGHLNIGAGRVVWQDVVRIDQTIKKGELDDNQAIKKTFQGAAAGNGRLHLCGLVSHGGVHSKQEHLYALLRAAKKYQVPKVFIHFFGDGRDTDPKSGAGYMQELVDYLKEVGIGQIATVVGRYFAMDRDKRWERVEIALKGMCHGEGEASEDPVATVKARYERGGNKDKDEFLTPIIVGGDEARIKDDDTVFFFNYRSDRVRQITQLLGDVDRSVLEDFKYPKINKLVTMTTYKTDYPFKVAFEPQRMGNVLAEWLGKQNVEQVHVAETEKYAHVTFFFNGGVEKVFPLETRDQDQDLVPSNKSVATYDLAPEMSADGVADQVVKRLGEQKFPFVMNNFAPPDMVGHTGVYEAAIIGCEATDKAIGKILEGCKKEGYILFITADHGNAEEMKFADGKPKTSHTTNKVPFIMANAPEGWSLKKQGGVLGDVAPTILAAMGLPQPDEMTGESLLDKNLKRGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUY7</accession>
    <name>A0A7D5UUY7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nagZ_1</name>
        <name evidence="6" type="ORF">G6M90_00g050620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI67675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689680.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="536" mass="57701" checksum="7A309B0F7D8955E0" modified="2021-02-10" version="1">MPSAEQRRVVGQLFAVGFYGTEINKEIKSLIQDYGVGAVLLFKRNIKDAAQLQALCLGLQQLAKDAGHTQPLFVGIDQENGLVTRISPPVAAQLPGPMALGAAASLESAYHVAKATGNMLRYFGINMNYAPVGDVNNEPLNPVIGVRSPGDDADEVARFAAACAKGLRETRVAPCIKHFPGHGDTAVDSHYGLPVVNKTREELEALELVPFRRAAAEGIEMVMTAHIALPKASGSHLPATLSPETIKILREDLAFEGVIITDCMEMDGVRAAYGTVEGALMALKAGVDNVMICHTYDVQAASIDRVCEALHAGELSQARLDASLKRLRDLKDKYTDWDTALEARPPSDLARLSTENEALARDIYANATTVVRSEAGLLPVSRSASTVFVSPGVNVPTSGAASSGEELQKTRVPWVSGAFGDTLRRYNPAVEDIRFTESTLTSEQWARVEDAAVVVLATRNARESQYQRRLGLEIARRRAGKTLVAVATCSPYDFIDDEAEVRNYIAVYEPTLEAFASAADIIYGAATARGRLPVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV71</accession>
    <name>A0A7D5UV71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g033430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986517.1">
        <property type="nucleotide sequence ID" value="XM_066130129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV71"/>
    <dbReference type="GeneID" id="90967602"/>
    <dbReference type="KEGG" id="mbrn:90967602"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="25907" checksum="85DD9D11210D3844" modified="2021-02-10" version="1">MHLCYAEIRRHTTEYKNIFHSSTITDINLHQDLASKMTTLLVYDFEAAISLGQFEDLQTIIGNAKLYKDLQTFKCLGDILLQYPIPAQVLTTTLKTISNEIHRLEQFDAAKLCRYLRIILQTTVSVNDTAALQIIGQIMKVAHESRDAGTLLPRADLEWIAAITFNHAIDYYALSEETSCRVWAAKSMELAEYLNDRGRLAKTLRDRFGQLRFESEICSWQVDKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVF8</accession>
    <name>A0A7D5UVF8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fluoroacetate dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DEHA</name>
        <name evidence="4" type="ORF">G6M90_00g046000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544727.1">
        <property type="nucleotide sequence ID" value="XM_014689241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVF8"/>
    <dbReference type="GeneID" id="26242068"/>
    <dbReference type="KEGG" id="mbrn:26242068"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="298" mass="33413" checksum="ACF7188DF009A422" modified="2021-02-10" version="1">MFDGLIPFSITTQTDPLVTIKGLQTSPESPLPPLLLLHGFPQTRHIWHRIVPHLTTTYNLIIPDLRGYGESSKPPSVAAYAKSAMAKDMICLMNHLGHKTFFVCAHDRGARVAHKLLVDYPNLVRKAILLDICPTLSMYQATSQEFATAYFHWFFLIQPAPLPETLISATPRKFAELCMGGKDGKGLHIFDKACYEEYVKLFEDEDTVHAMCNDYRAAATVDLDEQRADLEKGRLINAPVRIIWGKKGVIEKCFDAMAEWRKVVGEGVVLDGYSVDSGHYIPEEAPDDVVKAVCEFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVG0</accession>
    <name>A0A7D5UVG0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CCS1</name>
        <name evidence="12" type="ORF">G6M90_00g041950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547535.2">
        <property type="nucleotide sequence ID" value="XM_014692049.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVG0"/>
    <dbReference type="GeneID" id="26240098"/>
    <dbReference type="KEGG" id="mbrn:26240098"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="248" mass="26481" checksum="987112158F6C6E01" modified="2021-02-10" version="1">MTVDHSFQTVFAVPLSCNGCVKTVSDSIYKLGGVSKVEGSLEDQLISVEGFAAPSAIVEAIQATGRDAILRGSGASDSAAVSILESFTGKLQREDDNGDREVRGLARMVQVSSGRTLVDLTVRGLAPGTYRATIRQYGDLKHGAKSTGPVWSGDQSERNGVLGDIDVGQDGRGAAFVDHPFRIWEVIGHAMVLTRQNEAAGPLENDDNTVVGVIARSAGVWDNDKTVCSCTGKTLWEERRDEVRKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVQ2</accession>
    <name>A0A7D5UVQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PLPHP</name>
        <name evidence="5" type="ORF">G6M90_00g051300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539816.1">
        <property type="nucleotide sequence ID" value="XM_014684330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVQ2"/>
    <dbReference type="GeneID" id="26247371"/>
    <dbReference type="KEGG" id="mbrn:26247371"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="284" mass="30491" checksum="F67A476210BC5A3C" modified="2021-02-10" version="1">MSEAEEMRVDPTRAQALISQLSSVKERIGGLAHGRDVRLVAVSKLKPANDILALHQAPASHRHFGENYTQELTQKAQLLPKTIQWHFIGGLQSGNNCYSPASHRQVHSGPLTHLPGHCKTLAKIPNLFCVSSVDTLKKAALLNTTRGALLASDPSLPKLSVHVQVNTSGEEAKSGCAPGEETVALCREIISNCPNLHLLGLMTIGAIARSKATTADNENDDFIALKQQRDLVARQLALDDARLELSMGMSEDFEGAVVLGSGEVRVGSTIFGTRPAKADAKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVR2</accession>
    <name>A0A7D5UVR2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High affinity iron permease ftrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ftrA</name>
        <name evidence="9" type="ORF">G6M90_00g048980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545009.1">
        <property type="nucleotide sequence ID" value="XM_014689523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVR2"/>
    <dbReference type="GeneID" id="26242350"/>
    <dbReference type="KEGG" id="mbrn:26242350"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39125" checksum="1EA541D293702AC3" modified="2021-02-10" version="1">MAKDVFSVPIFLVVFRETLETVIIVSVLLAFLKQTLDGPERDVRTYKALRRQVWLGVAAGFFLCMVVAAALIGVFYTVGSNSWDKNENYYEGAFCLFAAVIITVMGAALLRIGKMQAKWRVKLAKAIESPIKAGSRGCFSHWLEKYSMFVLPFITVLREGIEAVVFVAGVTFSAPAYAVPLPVVVGLLVGGIIGYLLYKGGSTAKLQIFLVASTCLLYLVAAGLFSRGVWHLEAQKWNNAIGGDASETGNGPGSYDIDKSVWHVNCCSPTSTSDGGWGVFNAILGWQNSATYGSVISYNVYWIFVIAGFIVMRFKETKGHWPFMKAKAPAAREDSVSGSSSPQESEVVKSTNVTEKTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWC7</accession>
    <name>A0A7D5UWC7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g044780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986573.1">
        <property type="nucleotide sequence ID" value="XM_066130358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWC7"/>
    <dbReference type="GeneID" id="90967687"/>
    <dbReference type="KEGG" id="mbrn:90967687"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8437" checksum="894DDFE19D5551D2" modified="2021-02-10" version="1">MRDATLGVARSRENGSWESAVKRFVWEDARSTRSHDFVTVLLFLSVKCFGSSRQAGESAKMLPDEDFSSAARIANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWE9</accession>
    <name>A0A7D5UWE9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g033300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687774.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWE9"/>
    <dbReference type="GeneID" id="26244061"/>
    <dbReference type="KEGG" id="mbrn:26244061"/>
    <dbReference type="OrthoDB" id="5213490at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="87046" checksum="30AC9CFE5084F79F" modified="2021-02-10" version="1">MSLPSYQEATAGTDWLLLVAPFCDFDDYRSLCLVSRRFRQIFAPRLWNDLLCSVRRIGLDPGDDLTWWFDFVFNKLDRVGRATRDLVQALDARHFAKDAFDFSSDQNERRLTSSLQRALTLLPHVNTILLDGHADIDHAVLLGTQSLAALGLNNLRILSIKDCSCQLPNVFFNTPHLQKLIYLDMSNLPGSLISLLQSDLLPALRILKVRGRELDDSALCFLMRRFGPQLWSLDVGSNKISDDAVQIFKDWGLPASQLRTSDHFQVEGKIVTQSWGTADYGHFLCIQESDLSGSFCHPERYFVDAPAYTSHANMAPQEYQVHRLDGNQAVRRDSADAVKEAMSEEHQSRLGTDDYLFSTGITHLRLSYNRLSAHGIQKLLRISNGCIEDLTCDAMPLLPNVGTYRKAWPPKSNLDGILGAAHLFRPVFSSNLRVLRIHHSLVTNIPSLQMVGLSSLARLFLSETAILRRVERAYPQTFTPDMNPRLLSLTLTCLPRRSSGPLISRLLQFLKLLAIQERGIQEALLSASTRRSPGVLQGLRHLRLEFEPDSMEEGFSTSEDLDPEELMNSGEKVFSFFEDERMESWSRSRARQMLHSKRVAVHSPAAVDNQASGSDRDNPEFVTYDADWSGDRFSIPVWAGPNDPDAPEVLKDYRRLVLERHVRDGVGPASPAQILAGAPSRSFIFHVAWSAAVMPSDLRPPTRSELAGMSDVLDELKTYRLNGRANYMQHKELAQMAGRHVSLGETHFFWTGRLEVSTEATLPLAQSSQYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWV4</accession>
    <name>A0A7D5UWV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">TSR3</name>
        <name evidence="10" type="ORF">G6M90_00g043060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547640.1">
        <property type="nucleotide sequence ID" value="XM_014692154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWV4"/>
    <dbReference type="GeneID" id="26240203"/>
    <dbReference type="KEGG" id="mbrn:26240203"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="83"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="437" mass="48593" checksum="0E87757E81ECAE40" modified="2021-02-10" version="1">MVRHKKDFAARGKKSGRGGGHGGGGSRQPRHQDGDQGQQPARPAFKAACWDLGHCDPKRCSGKKLMKLGMMRDLHMGQRHHGVIITPNGRQVVSPADRELMDQYGAAVVECSWARTQEVQWSKVGGKCERLLPYLVAANTVNYGKPWRLNCVEALAAAFYICGHADWAEQILAPFSYGESFLHINASILKRYAACQDAAEVKKTEAEWMERLEREYAESREQGHGDMWTTGNTNRMAMPPSDDDDDADDDDDDDDDDEGEGEGEEGDSDARSDGRGSVDGIYLGKKPLDPKPGEIPANIPDEQARRDKDPFDITDGSEDDDAAMEEIRRKVLASKTFSNPNPELEQEKKKPASIPRPQQRHRYQVDLDMQPDSDNERSADNQDDSDAAGDDDEFDNIIEATPVTDRIGLAKLEKERRQATTTTKTFSSTSVSAPNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXA1</accession>
    <name>A0A7D5UXA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA recognition motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g057700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544352.2">
        <property type="nucleotide sequence ID" value="XM_014688866.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXA1"/>
    <dbReference type="GeneID" id="26242764"/>
    <dbReference type="KEGG" id="mbrn:26242764"/>
    <dbReference type="OrthoDB" id="5408296at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46996" checksum="355F1AB043D15AF7" modified="2021-02-10" version="1">MAARAGEENVATLFGDVHYFYEPENARPRHHRFDKGSYVYLFENAHDRRCRIEIANQPGTDEQDAFDGFLDQARVRYSYKQHCAVSLIVADSVDHNEWHLPTYDPRNDKKYHYKLHSLDIYFWTQSDALRFVNGVRRVLPSVQVEVLDEPCHQQTIGMSSVVQKLENVAVSDPQYGNTTSSSSEIVSQEPTVDPAPAASLDVLVNPLPPPPPPPASFAPMAYNPAAPAAPETIRHREKTPPPDEDPLNPLAVAVAHDYQKQPFTPGFPPQPQLSLGMASPGLPPNISNTSSLPLQFAGPPNQPGTQRAATMPANSGSAFSGPPGSPGFIPPPPPPQPSTQIPGHGTVAPPGGFSNYTYSHQSTLRQDGQDYSIHQQLYRPTEIEFGMNKPHQYQPKTETRGRLEENAGRLERGVSGMLKKFEKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXI5</accession>
    <name>A0A7D5UXI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta hydrolase psoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">psoB_0</name>
        <name evidence="5" type="ORF">G6M90_00g031270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543066.1">
        <property type="nucleotide sequence ID" value="XM_014687580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXI5"/>
    <dbReference type="GeneID" id="26243867"/>
    <dbReference type="KEGG" id="mbrn:26243867"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF13">
        <property type="entry name" value="ALPHA_BETA HYDROLASE PSOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="169"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="452" mass="50113" checksum="DB4B549BF12B0BF5" modified="2021-02-10" version="1">MVAMHTFFKSAFFNFEYLRLLAMAPHEGAEIGEALEAAAKIRDLDPESWFNAFLEAGNKAECIAKEAEQAGDVVSARRAYLRSSNYLRAAQFMLNEGKIGQDRRVLATLERAIGNFRKGVQYRAGKTFFLEIPFENGIKLPGYLYLPEASRRIPGRKIPILLNSGGGDSTQEEIYFVNPAFGPDIGYAVVTFEGPGQGIVLRRDKLPMRPDWEVVTGAVLNHLFDFAASHPDLELDLDNIAVTGASMGGYFALRAAVDPRIKACISVDGFYSLASFVGGRMPGPLFNGFMKGWLSDRTFNAILGFLQRLDFQARWEFNHLKWATNSTTEAEIMRSFGDYTLLKPDGTEYLADVKCPTLVTGAGASWYFDPATTTDKIYDCLTSLKDGVDKEKWIANDIAYGGLQAKIGAFGYSAQRTFQWLDMKFGIRRETLNATSDLGSLVKNTAKNTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXW0</accession>
    <name>A0A7D5UXW0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g064620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540082.1">
        <property type="nucleotide sequence ID" value="XM_014684596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXW0"/>
    <dbReference type="GeneID" id="26247118"/>
    <dbReference type="KEGG" id="mbrn:26247118"/>
    <dbReference type="OrthoDB" id="3001700at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12215" checksum="F604F85F0EF8B19E" modified="2021-02-10" version="1">MEWASAQYQKQKDIWIPWIEDMYLKYFTSDNKASYTTRDNLDKTKVTGNEQVDKLQDGVHGLVAGQLSQGGLAQPVGDLVSKQGINRAERQGVDEEGKYLPKPGDAVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY41</accession>
    <name>A0A7D5UY41_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nonribosomal peptide synthetase 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NRPS32_1</name>
        <name evidence="4" type="ORF">G6M90_00g052680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540395.1">
        <property type="nucleotide sequence ID" value="XM_014684909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY41"/>
    <dbReference type="GeneID" id="26246757"/>
    <dbReference type="KEGG" id="mbrn:26246757"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF15">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE EASA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
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        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="151" mass="16918" checksum="1BBB1FE155A29AA3" modified="2021-02-10" version="1">MDARFDAVVISKKQILGLCRQFRHVVEQLDNIDQLDTLDDIRLASRDDVDQVISWNASQPWEGVEKTFHDIISDQVHLTPNAVAITGWDGQMSYLELDEHSTWVAKILVSKSIGHETVFPLCFEKSKWAVVAELAVLKAGGVVTQLGAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZA5</accession>
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        </recommendedName>
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        <name evidence="6" type="ORF">G6M90_00g078390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZA5"/>
    <dbReference type="GeneID" id="26241302"/>
    <dbReference type="KEGG" id="mbrn:26241302"/>
    <dbReference type="OrthoDB" id="4934609at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADP-ribosylation"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028838273" description="Enterotoxin" evidence="5">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31380" checksum="40050153393B2D04" modified="2021-02-10" version="1">MKNFAALLFASALAVPLAASAVAPQGSTLPEGPLPSVVYRGDDLPPEYYKNLGGIPHEFEGKTDNRSYSLWWHNVGLDGWVGKMRGKNRHFNSAYAATSSRWSSALYFAVLTREQEFGWMYQIHATPNMIYLEGSGFAPPFTDEVEYAALGGIRWDQIEAWLRVPKNVTSGDRKTFKSDGTLAKWALLENFTKDFPDLKWVKNPDYNPAYNQYHGSEGQPQLGGRPIKVKGSLQLDIPREFEGKSMEYHAIEFMNKVGGPVGWIGAFPLNFSAAADFSAAEI</sequence>
</entry>
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    <accession>A0A7D5UZX4</accession>
    <name>A0A7D5UZX4_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">GTPase-activating protein GYP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MSB3</name>
        <name evidence="3" type="ORF">G6M90_00g068970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GTPase activating protein (Gyp3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="551"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="932" mass="102850" checksum="9580D7E96963D462" modified="2021-02-10" version="1">MDSMAVPQSDEEGSIPPGQHTVRNRKYSLYASRIKPLTVDTSAREKVPQLPEIPPLPVSPRWDSLSHGLHLLNQSPTSGSRVSPIMLSEAMLPQPFPALAGPAVSPSLRSPRSLRIGTPEPRNESPCRSMKAKTSLADMRSSEGTPLVENFSRPRKQSIRQAGPPENLHIPDPIRPRQANMPNLTDRFLDLANPLSQTPPWQRPRRPSASSVKSSSTYASPLPYTNSDFIESRHRARNVTGPPALTPARTPAVPGRPEYPVSTPLTSPGAGGTAPWLSGDELRSSFRSQLTASTTPGTAVTERSSVLTKDSSVTSLENPDEPSLEDVMGMYEKGFADDENESDFDDPESEGNLDSRPMTAVSEPDTRSAPAVPSIPFTVPVADKSLEPPLPTARSTLDAEIRQSKMIFTSPAFTASVAAIAGKADVDMPEKRDSAKSLDSEPSITSDPAPAKELPTTVNLPPPASKPALPTATPMPVEPEDPGSRDRYGFKKANQSITREQYDAWNAEYSVYIARRRRKWVAYLKDCALMTDRPIRFPSPSAKTKRFVRKGIPPDWRGAAWFYYAGGPAILAKHAGLYERLLHKSAKQVDIEAIERDLHRTFPDNIQFKPSANFQSVPNSERTSQSTMTGSSGDESSPGPLPAASNEPPIITSLRRVLHAFSIYNPRIGYCQSLNFLAGLLLLFVETEEQCFWLLNVITIIYLPGTHDMSLEGSKVDLGVLMTELRDTMPSVWDKIGGELENLPTGRPSTSKSIRKTRPILRRREHPKLSTDRLPPITLCMTAWFMSCYIGTLPIETTLRVWDVFFYEGSKTLFRIALAIFKSGESEIKAVKDPMEMFGVVQAIPRRMLDANALMEACFKRRNGFGHLSQGAIDERRQERRQRAKQELEQSLQQREKTDLGGNLTEVESGSVSRKGTLFGRKKSANLRAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Y8</accession>
    <name>A0A7D5V0Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cutinase palindrome-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CGPB</name>
        <name evidence="8" type="ORF">G6M90_00g091250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686289.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245243"/>
    <dbReference type="KEGG" id="mbrn:26245243"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI72010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="500" mass="54104" checksum="199A95549E2BD922" modified="2021-02-10" version="1">MSHDPPPPPPPSGNFYGFSPFNLNDLNNAQNSPFPAGGPSNHDLMSFFDDADMMDPFGDVSMNIDSGNGAQVMPVPSSMPANTNEDVAMMNDADAQASSSNAAQPQDDPLAMAVEKVPGAGPLPPRTFAQMSLNGGGSSGSASASTLTDFTKRRNWPAKVVEELKDFLHILDANGRIKYASSSIFGISGYTAAEVQDVFLKDLIHPDDQGVFVAELNESIASGSPLRMFYRFKTKSGNYTVLETVGHAHIAAARFAPNPNNQSPFCQAVFMMSRTYPTKNAGLLDSFLEHKMENERLRRRISELRREEEAETEESNRQWVQSQEGRSDMTPSETTGTSTPFFRNASSTSDMQADGSALTRENLEGVAAGRNSDSLGDKMARYEGSTHAETIELLTGLRYLEGERSRGITTGGSSPTLIRGDAGIAIPIDRDARAGEKKKKLKTAEEYVCTDCGTLDSPEWRKGPNGPKTLCNACGLRWAKKEKKKTNASQKGAVADQMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Z5</accession>
    <name>A0A7D5V0Z5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g092640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541908.2">
        <property type="nucleotide sequence ID" value="XM_014686422.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Z5"/>
    <dbReference type="GeneID" id="26245376"/>
    <dbReference type="KEGG" id="mbrn:26245376"/>
    <dbReference type="OrthoDB" id="10515811at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13439" checksum="D70623050D1F1A2D" modified="2021-02-10" version="1">MVDRSENAHPRKRRGGTRQTQDSIDSEPNAILIYTDGGSFNGREGTAVVCTANQTQKAYTSAIKEPGHVWDIHTLLDYAAKAWGTHFREADIVVSPRLCDPDDKSHSVRSRIDSSATGMKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V139</accession>
    <name>A0A7D5V139_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">frs1</name>
        <name evidence="18" type="ORF">G6M90_00g087900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542325.1">
        <property type="nucleotide sequence ID" value="XM_014686839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V139"/>
    <dbReference type="GeneID" id="26244839"/>
    <dbReference type="KEGG" id="mbrn:26244839"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI72416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="610" mass="69132" checksum="6CAEB3440B29F49F" modified="2021-02-10" version="1">MPTISVDKYKLFEALGKKFTKEEFEDLCFDYGIELDEDTEDQERPIVDGQQEPPQLKIEIGANRYDMLCFEGIALNLNIFLGRIKPPNFRVVEPKDANTQVIKVLPDTTKVRPYVSGAVLRNIKFTADRYESFIALQDKLHQNLARNRTLVSMGTHDLDTIQGPFTYEALPPRDIKFIPLNQTKEMNAEELMTFYETDKHLGRYLHIIRDAPVYPVIYDANRIVCSLPPIINGEHSKITLNTTNVFIEITATDMTKLQIVLDMLVTMFSGYVQEPFTVEPVKIISEHNGLTRVTPSLKPRVTHAEVDYLNSCTGLSETPEGLCKLLTKMAYDSRPSDKDPNLLEVSIPPTRADVLHQCDIMEDLAVCYGFNKLPRTAPTRSATIGAPLMINKLADIVRFEAAMAGWSEVLPLILCSHDENFAWLNRKDDGKTAVRLANPKTLEYQIVRTSLLPGLLKTIRENKGHSVPFKIFEVSDVAFKDESSERKARNERHFAAAWCGKSSGFEVVHGLLDRILSMLRTAFLTHDEGLTAKESVDYQVKQNPTKADGYWIEELKEETFFPGHAAAVHLRLGGKDRRIGEFGIIHPTVLEKFDLRYPVSTLEINLEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V170</accession>
    <name>A0A7D5V170_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lsm7</name>
        <name evidence="11" type="ORF">G6M90_00g084210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543637.1">
        <property type="nucleotide sequence ID" value="XM_014688151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V170"/>
    <dbReference type="GeneID" id="26243814"/>
    <dbReference type="KEGG" id="mbrn:26243814"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="43"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI72170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="131" mass="13806" checksum="99210AF8E77FE025" modified="2021-02-10" version="1">MSDRPTHRGGRGGGGPRGGRGGGRGGRDGGRDGGDKGEKPKKENILDLAKYMDKEITVKFNGGREVTGTLKGYDALMNLVLDEVKETVRDEEGNESTRPLGLVVARGTLLVVIAPVDGSEEIANPFATAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V198</accession>
    <name>A0A7D5V198_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g089110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541575.1">
        <property type="nucleotide sequence ID" value="XM_014686089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V198"/>
    <dbReference type="GeneID" id="26245438"/>
    <dbReference type="KEGG" id="mbrn:26245438"/>
    <dbReference type="OrthoDB" id="4935480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028825533" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="50726" checksum="4CE06BDEFA3152E0" modified="2021-02-10" version="1">MAGIQDLTVEILMIIFDLAIAMRDPDYDSPETSSCAIPGDGPAILNLALTCSRFRDVVEQVKFRYLFQYDAFPLKADDMKRFGFMLNPVNWPRGLRNALQRNRELGNQCRELGVNLTGDQFAGREEFLRSLEEIVPDLPNMTKLWIACSFKRTTEMQNTLYPRLLDPVKDMSRLVTVAILTVDHMRELDSLYSMQWPSSVRKLHLGITSNLKESERAEGQPMLRGECNITSLSIAGTQNLFDFPSVLEGFPNALEELTLLDCSRPTPHIPFPMRFDGHKHSLRALSLVFSAFGVPSTLNVSDCTALEHLSLHYGELKYPDRLGFVACDDAEQFAARILGPRLKRLTWVFHYKNEPGLLKTLSVSSHSVRERLHRELAVAAGERAAALEKIHVIWVPRKDFKVQYPDPVKAIVVDKVNLSEKVTLTYSAAGMPDETRLEVSRALQRHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V297</accession>
    <name>A0A7D5V297_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoporin NUP49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NUP49</name>
        <name evidence="9" type="ORF">G6M90_00g073430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987204.1">
        <property type="nucleotide sequence ID" value="XM_066130986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V297"/>
    <dbReference type="GeneID" id="26241755"/>
    <dbReference type="KEGG" id="mbrn:26241755"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="441" mass="45976" checksum="7D34763C25752558" modified="2021-02-10" version="1">MSLARSASVPGGLTINTGAANSLGTSTIQPSAPTGLFGSGSTSANPATSTTGGMATTGSIFGGAQQKAGTGLFGSSTTAAQQPSTTGGLFGGAASNQQTQQATMTGGGGLFGSTATGQQQSQPASGGLFGSNPTVTQQQQQPQQAGGGLFGSGTANTQSTTTGGGLFQQSQANPSGGLFGQSQPQQTQATSQVPAVQINYDNLRPRTRFDDLAKPVQDEIALIDKGIQRVIKMKDEIGEFMPQHEKDIEQLGRDVKFVETKFKTVQVALNQDIQTVKVLQDMTKKSITDAQLSFKATDNLKLPTHYHQTGLFAGPTSSADSNGTDAASAHANAQDLITYFNRICDDVEKYKKRLDEYRGEIERDMPGVENGLYEQIRSLRDRNAAVGGAVQDQLGQVLSALRETGNAIVAQAGQIADTRERLSRLQAGILDSGVYAIGMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2X7</accession>
    <name>A0A7D5V2X7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g085290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541086.1">
        <property type="nucleotide sequence ID" value="XM_014685600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2X7"/>
    <dbReference type="GeneID" id="26246075"/>
    <dbReference type="KEGG" id="mbrn:26246075"/>
    <dbReference type="OrthoDB" id="4924482at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="180" mass="20552" checksum="5C4C801C0B565EA6" modified="2021-02-10" version="1">MPGGKYRVSVAGFRRDGISDDPSLETTYGHAMYHWGIWVEPKNTPGAGRLYHVEEHPSMNSAEGVIPGGWKMEPRNSDAQSSRRLIGRIMIGKLPAGKGYREIEALLRQVPAPVEGSSENCITWTMNAIRLLQGQEPTPWAEEFNVEEFMDHAYSRIKGWHRLKDWLFAAYKESYVKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Y4</accession>
    <name>A0A7D5V2Y4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LIPA</name>
        <name evidence="3" type="ORF">G6M90_00g094690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540832.1">
        <property type="nucleotide sequence ID" value="XM_014685346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Y4"/>
    <dbReference type="GeneID" id="26246445"/>
    <dbReference type="KEGG" id="mbrn:26246445"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029171">
        <property type="entry name" value="Esterase_LipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029086098" evidence="2">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="454" mass="48249" checksum="538BA7F448AD3F8B" modified="2021-02-10" version="1">MICQLALWLTLFSWTISGDAGVGAVLEARAPPPLPSADDFYKVPDNLDSYAPGAIIRHRPPPNPIAVAGLIHSQNQYPVHVDASYQLLYRTTDSLNNATATVLTVLVPRNANFNKVLSYQAVDDASNIDCAPSYAFQLDSGPSVAQGEVLLVEAALEQGWVVIVPDYLGPKGAFLANVLAGQAVLDGIRAARNSGAITGIGKNPTVTLWGYSGGSLATLFAAELQPSYAPEVVIAGAAAGGAVPNITTVLGKVDGTGAAGLIPAGILGLAHQYPEVDALIQKHVLPQHKDEFYKADKLCLLGNINEFSGKNLSQFVDDPSLLYANPTVVRIAGENDLGQHAPKAPLLVYKATKDEVSPVAETDALVDWYCKQGTTVQYLRDESTDHESLAVTGAPKALAWLRGRMNGEDRQTACETKTVYSVLLDFGALAILPKVLLDAFLDVIGKRVGPFIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V386</accession>
    <name>A0A7D5V386_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">G6M90_00g085020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987476.1">
        <property type="nucleotide sequence ID" value="XM_066131263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V386"/>
    <dbReference type="GeneID" id="26246051"/>
    <dbReference type="KEGG" id="mbrn:26246051"/>
    <dbReference type="OrthoDB" id="4937014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028998435" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="22"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI72459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="438" mass="48822" checksum="02CDF3ECDA8BE241" modified="2021-02-10" version="1">MRLKQASTYLLALTLPWHCLGASNTKVPSAADLAASFTKIPPCALECLAQSVAEAGCGLTDPQCICVDEYVAIEKAGAPCILEACSLTEALSTKNVTETACLKPIRDSSRRYDTMNILLGVITALLVVIRLLFKKFFSYRRELGADDWVILATVVIGVPCTIINKVGLTANGLGRDVWTIPVDQLIRFVMFFYIMEVLYLTEMALIKLSLSLFYLYIFPGSGIRRLLMGTAVFNVVFGFTFVTTGIFQCTPVSRYWTQYVDPDSPGHCININLFAWIHAALNIALDVWMIALPLSQIKKLELHWKKKIGVTLMFLLGTFVTIVSILRLQSLVDFANSTNPTWDNWIVAWWSTIEVNVGMICTCLPTVRLILVRAAPRIFSTNISHNKSDPTHNGTHNRYSRNSKIMGHKQIELASIETRIVEEGEKPRKARAFFGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3A9</accession>
    <name>A0A7D5V3A9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="16" type="primary">psd3_1</name>
        <name evidence="12" type="synonym">PSD2</name>
        <name evidence="16" type="ORF">G6M90_00g104540</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541448.1">
        <property type="nucleotide sequence ID" value="XM_014685962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3A9"/>
    <dbReference type="GeneID" id="26245698"/>
    <dbReference type="KEGG" id="mbrn:26245698"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000295">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5029078178" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029078176" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="240"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="491"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="174"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="388"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="836"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="894"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="981"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="981"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="980"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI73730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121074" checksum="D5E8F378E90AEB20" modified="2021-02-10" version="1">MRSKTDKTDNAGGPGGEAAGGLALKLVILKARNLAAKDRGGTSDPYLVITSGDSRVVTHSVSKTLNPDWNVIEELPVNSAQNLLLDVICWDKDRFGKDYMGEFDIALEEIFQNERTEAEPRWFPLKSKRPGKKTSVVSGEVLLQFTLLDTTNPGASPREILDKFSALVRSISASMPSPKPHLTPEANQGATSMPGQEEPGDEEDEDDLTEFDDEEGDDPSKPETAEKRRRRLRIRGLRKRRRDNPYAFNNGGSDVVGIIFLEIVKITDLPPESNLTRTSFDMDPFVVASLGKKTYRTRRVRHNLNPVYNEKMIFHVQGHEQTYSFSFTVIDHDKYSGNDFIASCNLPVPQLIERAPQANPETGLYELREPDGHTPSATRSRFKKLGMSRSSSTQSLGKLMRTQVSKSPPNTNTLSQSTSVETSQTPSAMTLSPVSDAPANPAEPSDTVAEGEGADFHDYVVPLKMKNLDKWESKHSPQIYLKAKYMPYPALRQQFWRAMLRQYDTDESGEISRVELTTMLDTLGSTLKESTIDSFFQRFPHKAADNEETWDLTMDEAVICLEDQLEAKSKPTTVADKVKSLVPDLKQLGIHNKPDITGDLSSANVSGTSTPQIVVEPETPIDPKGSGGEESDEFGDRDEEHVVEIRECPICHQPRLNKRSDTDIITHIATCASQDWRQVNTVLMGGFVTASQAQRKWYSKVITKISYGGYKLGANSANILVQDRMTGQINEEKMSVYVRLGIRLLYKGLKSRDMENKRIRKLLKNLSIKQGRKFDDPASREEIEKFIEFHGLDMSEVLLPIEEFKNFNEFFYRALKPNARPCSAPNNPGIIVSPADCRSVVFNQMTQATKIWVKGREFSIKRLLGDAYPNDAARYENGALGIFRLAPQDYHRFHIPVDGIMGKPITISGEYYTVNPMAIRSALDVYGENVRIIVPIDSVAHGRVMVICVGAMMVGSTVITRNAGDEVKRAEELGYFKFGGSTVLLLFEPGRMVFDDDLADNSSTALETLIRVGMSIGHSPDVPLHTPDMRKSEDEITEAEKKEAKRRIQGNFAMEQSPSDSGDDDVPKRRISYVPTMNTMAASAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3K2</accession>
    <name>A0A7D5V3K2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g096950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987725.1">
        <property type="nucleotide sequence ID" value="XM_066131519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3K2"/>
    <dbReference type="GeneID" id="90968161"/>
    <dbReference type="KEGG" id="mbrn:90968161"/>
    <dbReference type="OrthoDB" id="4976098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11176" checksum="997C7FE132BA6B8E" modified="2021-02-10" version="1">MSTSLSDSVVLMDMIRANMRVLRPEYDIDIVTYAELGNLTRVCIIRRVANASRYSTPSLLLKSGLPGGLQMGLKDVLQQTEDLLRPKLERVVAELGAGQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Q8</accession>
    <name>A0A7D5V4Q8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cot-1_0</name>
        <name evidence="16" type="ORF">G6M90_00g097490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546592.1">
        <property type="nucleotide sequence ID" value="XM_014691106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Q8"/>
    <dbReference type="GeneID" id="26241015"/>
    <dbReference type="KEGG" id="mbrn:26241015"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="109"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="412"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI73853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="488" mass="56195" checksum="FFF1CB0D526A1DBE" modified="2021-02-10" version="1">MEYYHIAAPANQRTLAIPGLFAPVPKRSPDKYSQNANNNQKKCSQQATAFFKDSVKRAQERNQRQSETERRLQEPNVGQEKRDQIWLTTGRKEGQYLRFLRTKDKPENYQTIKVIGKGAFGEVKLVQKKANGQVYAMKSLIKTEMLQRDQLAHVRSERDILAEAESPWVVKLFTTFQDAYFLYMLMEYLPGGDLMAMLIKYEIFSEDITRFYMAECILAIEAVHKLGFIHRDIKPDNILLDHGGHVKLTDFGLSTGFNRLHDNSYYQQLLQGKSNKPRDRSSVIDQINLTVSNRSQINEWRQSRRLIAYSAVGTPDYIAPEILTGHGYSFSCDWWSLGTIMYECLVGWPPFCAEDNHATYLKVVNWMQTLCFPDDIQLGPEAENFIRRLICNPEDRIGCGGAQELKAHPFFRGVQFDSLRRVRAPFEPRLASSIDTTNFPTDQIDQTDMASRLKAQALQGAETPLEDSLEMSLPFIGYTFKRFDTNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4R1</accession>
    <name>A0A7D5V4R1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g088880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542227.1">
        <property type="nucleotide sequence ID" value="XM_014686741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4R1"/>
    <dbReference type="GeneID" id="26244741"/>
    <dbReference type="KEGG" id="mbrn:26244741"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="8187" checksum="124F06B8402BA51D" modified="2021-02-10" version="1">MGLVDAKNRVPQHQRFYQQAYKAHTRLWLIGTRSRWYMTPYLIVLWGGFGATLYAAGRKVTGHNTWFGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V521</accession>
    <name>A0A7D5V521_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
            <ecNumber evidence="4">2.5.1.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">atmG</name>
        <name evidence="20" type="ORF">G6M90_00g106040</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19361"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17653"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.29"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22408"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EC" id="2.5.1.29" evidence="4"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539595.1">
        <property type="nucleotide sequence ID" value="XM_014684109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V521"/>
    <dbReference type="GeneID" id="26247592"/>
    <dbReference type="KEGG" id="mbrn:26247592"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF70">
        <property type="entry name" value="PYROPHOSPHATE SYNTHETASE ATMG, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02400)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI74497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="331" mass="36824" checksum="C3DF4028260CD545" modified="2021-02-10" version="1">MSTSAPNTNELNSPVLETQPLAGDAALLHSSIAAGYEEIIRAPFDYLLNLPGKDVRSKMISAFNQWLCIPADKLEVIKRIVMLLHNASLLIDDIQDSSKLRRGLPVSHHIFGVPQTINAANYAYFLAQQELPKLGDPKAFEIYTEELLSLHRGQGMDIYWREASKCPTEEEYFSMVSHKTGGLFRLAIRLMQLASDKNCDFVPLVNVLGVIFQIRDDYLNLQSHAYTVNKGFGEDLTEGKYSFPIIHSIRSDPTNIQLSSILKQRTTDVDVKLFAVECIKATGSFEHCKEKIAELVAEARQLIKEMGNSGPGSAEAVDRVLDLIGLEPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6J5</accession>
    <name>A0A7D5V6J5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">hnt3</name>
        <name evidence="22" type="ORF">G6M90_00g096870</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546649.2">
        <property type="nucleotide sequence ID" value="XM_014691163.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6J5"/>
    <dbReference type="GeneID" id="26241072"/>
    <dbReference type="KEGG" id="mbrn:26241072"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000017">
        <property type="entry name" value="Aprataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HIT" evidence="20">
        <location>
            <begin position="78"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="21">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QLI73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="281" mass="31546" checksum="28DC5AA8C4DFDC89" modified="2021-02-10" version="1">MDSDPDEAITKDEIQSTAPAPPLPQNAFTALMAPKPKPKPPSRTAASTSLAPQASRPNPFKDRLGLGAYISSPSSFPPSIIIYENADFVAIHDKYPKSTIHTLLLPRSPSHNLLHPYEAFKDEAFLAKVQKEAAKLKALVAAELQRRLGRYSKADAARQAVLNGDKDSEDGELPGGRDWESEVKVGVHAVPSMTHLHIHVLSRDMHSSSMRHRKHYNSFNTPFLVDVGDFPMSEDDERLDPKEQGYLRRDLKCWRCGRGFGNRFTRLKEHLEEEFVAWRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6Q9</accession>
    <name>A0A7D5V6Q9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Highly reducing polyketide synthase gloL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gloL_4</name>
        <name evidence="9" type="ORF">G6M90_00g113990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987807.1">
        <property type="nucleotide sequence ID" value="XM_066131908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6Q9"/>
    <dbReference type="GeneID" id="26247532"/>
    <dbReference type="KEGG" id="mbrn:26247532"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1115"/>
            <end position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131558" checksum="EAB69180423A9630" modified="2021-02-10" version="1">MLDHDKGIETNGKTAENLVKFSVWMQQQIENYKQGTNKFVDKNKRLEEKSAEQRLERIKEIMAILSSSPYAILAKAVDKLFSVAPAIFSGETHPLHILMEDNVLAEFYDAISMDSADLLKLCANTNPHMRILEVGAGTGGTTARVLRALTSSYGECLYRVYTYIDVSAGFIPAAKQRFASHEKIEYAVLDVAADPAQQGFQPGSYDLIIAANVIHATTYLNETLENMHVMVFNYVMVSILHIRLLHLQNMNGNLNLVQGFLHGWWLGAQDNRVDQPYVSPERWTKELLHAGFSKPEVIVLDDSAPYHVNTGILVSRESRHASLLAVSVLCYSPNSLYVSEMHQCLESLDVAVNICHFRQELPAHNDIISLLDLEVPVLHEMTEETFDTIKEYLSSHKAKILGVTPASQVGDVKDPRAAMWTRQRHRAVAAASAVGRILQHAGSEQLNNRESIDPDYEYAIIKGEAHHHEDAGPATYDDLEQRWKQPFPAEGDIVVETRAVGLNFRDFLIALGIIGNSPSEMGFEGSGVVRAVGPGVFRFSVGGDVMYLGSGCFKTIHTVNAALCVKMDDSMSFEQGAALPCVYTTALMALVDKADLKCGQSVLIHAACGGVGLAAIQIAKMLGAQIYCTVGSDVKRNHLAANYGIPPSHIFNSRDSSFLPNVLRATDGRGVDVVLNSLSGDLLQASWQCVAEFGIMVEIGKRDFQRRAMLAMAPFEANRTFTGLELRLVLQARPHKAAALLERCVGWIREGRIRGPTVSNTFEAVQVQDALRMMQTARHIGKMVVRMPRDARELDRPTMPTPSFQFRSDRTYLLVGGLGGLGRALATWMVEKGARSLVFLSRSCQKGPQTDGFVKELHSQGCQVLLVKGSVSNKADVQRAVDNEVTASRALAGVINLAMVLRDVAFADMSFADWNTAVEPRVRGTWHLHEAISDINELEFFVLLSSCSGIVGQWGQANYAAANTFLDAFVHFRHGQGLVASVIDLGVMGDVGFASQNHDLLENLGRMGMRILREQNLLDALVLALRASQPTQVATGQLGSQPGDACMTYRSPGQVLLGLNTTVPISSPLSRVPWRRDARMSIYHNLEVLSNTGGKQTCPLRDSLRATLAPLTNNADRTATIACALTAALANFLIKDENDIPLDRPLENLGIDSLVAMEVRNWIRQQIGVELSTISIVQSPLLFHLAEDIRLRMGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM57</accession>
    <name>A0A7D5YM57_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g008570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549652.1">
        <property type="nucleotide sequence ID" value="XM_014694166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM57"/>
    <dbReference type="GeneID" id="26239096"/>
    <dbReference type="KEGG" id="mbrn:26239096"/>
    <dbReference type="OrthoDB" id="5328813at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="500" mass="55694" checksum="8552C861A369AAFD" modified="2021-02-10" version="1">MQTPEKRRGGGGHALRTGSRHNHSTVSTPSTSGTAASSNPNSTGSGSGSGSNSMPAMPPRAAMVNNNAAVPEDAHETASSNASSGGASVTDKDKDGSSAPARSASIRYTASSSKERQKERDAVLVREKDERIAYLEREMGIMEREFQRELDKLSQNESETATFWQAKHSALNQQYLRTDTELRLLRAEVDVREAEREELRQGWEVLRRELKERDDEMRGLRSQIRGLKEFVSTSTRTDGQTSDEVFGDGMARLGNGLQNWVITNFRRTRLVDFAKVDEATLAELSELVPMYEALAQTVKVHLLQSVVSKILVEMVFDTYFVGLSDDQTRCFRQMEGLLSSFSTDESVNQWRASTLALIRRDAPQLLQSSTTEYVEKVISRINRILDSITDSSTSSAPSRSEARDSALRVLVNNSVELARLLVAQKAVLRVYMPEVLPHQQVMFEPETMEDLGDEDEEALARREIWCVVFPGVIKHGDENGGRMQFRNVIAKARVLCSPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM89</accession>
    <name>A0A7D5YM89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMN7</name>
        <name evidence="11" type="ORF">G6M90_00g006830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549826.1">
        <property type="nucleotide sequence ID" value="XM_014694340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM89"/>
    <dbReference type="GeneID" id="26239270"/>
    <dbReference type="KEGG" id="mbrn:26239270"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="974"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="904"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1006" mass="109824" checksum="4AF91D7D4ACC3C14" modified="2021-02-10" version="1">MPSHGSPSPGHQQGTKRQRQSSYDAASDRNSQTSPSEQLAGDASQSAAGPADAANAGPAKGGQSSNFRNVSACNRCRLRKNRCDQKLPSCASCAKVGVACVGYDPITKKEIPRSYVFYLETRVELLEKLLVANNISFPPAENLELCSRPSADAASTLSATDSGYSGQSESGDRAHRGQHHALEALKAKKAPQSPALASIISPPKARSLASASGVSFARVVFAAVQYSVSEQTGSAERSAGRKQSVSGASASMRDSFFGLHTRPTIQPAPFPKKEEGLRLATLYFEHANPQIPVLHRVEFMQTFEKAYKNASKGLTARELYMINMVFAIGSGVILGEPVRTPAPTNPRLPLDQAPGACQPEEYHASAIVHLEECLSTSGGYLEVLQAVLLLANFALLRPVPPGLWYITGVAVRLAVDLGLHHEDGGDADAIPPEPTSDPHAAQAAEIRDGSAQDRGRRHWIRDLRRRLWWCTYTFDRLVSTCVGRPFGVSDEIITTELPSLLDDEYITRNGFLEPPEGDDHPSYKHVAHHYFRLRLLQSEILQVLQHNQAQIARASNANQAKLYPEMRSHLPSPFLVHFDSFRSWRVDIDRRLYLWKVSAPTREETGVAFSTEFLELNYWQAIILLYRQSLSVPAMFEGEYNTSDEVNSPTAFTAELREDEDGIYLKVAEAGQKILRIYRQLHLSGLVSYTYLSTHHLFMAGISYLYAIWHSPVVRSRLSMEEVDFTVLAAKSVFSDMVDKCPPAETCRDAFERTAKTTIKMASSSGGFGVPPQQPRRRRRETMPWTSTQDGSSMKPPARAHRHRQSEAAPFPFDLSLSDGLSSPSMSNAGDMAAQHTPPLGKTSKTYDSDAFMSGQGAARSGPSPSDAMSQDDGGSSIDPSLVPSTPTTRRSAPQHGASGGSFLGQQFGLQGSMDYPDAQTMEFLNNLGATPDGDINGVDQAHMDLGFGMNWDGMHTEYGDGQQINPFDTFFFGGQQGSGGVGNINEDDKNNNDSSNGNSNNRNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT29</accession>
    <name>A0A7D5YT29_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GAD_0</name>
        <name evidence="11" type="ORF">G6M90_00g033370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543267.1">
        <property type="nucleotide sequence ID" value="XM_014687781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT29"/>
    <dbReference type="GeneID" id="26244068"/>
    <dbReference type="KEGG" id="mbrn:26244068"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="528" mass="59558" checksum="35E7DCD59EA9134D" modified="2021-02-10" version="1">MVHLSAINKDDSGSAASIANDAVAHLTQKARSTLKLSSEEDSLTTSVYGSRFAEQELPRFTMPERAMPREIAYRMIKDDLSLDNNPKLNLASFVTTYMEDEAEKLMAHSLSKNFIDYEEYPQSADIQSRCVNMIGDLFHAPSGNGIGCSSVGSSEAIMLAVLAMKRRWKIRRQAEGKSTERPNLIMSSAVQVCWEKATRYFEIEEKFINCTPTRFVIDPEEMVAKCDENTIGCVLILGTTYTGDYEDVKAVNDLLIEKNIDVPIHVDAASGGFVAPFVVPDLEWDFRCDKVVSINVSGHKYGLVYPGVGWAIWRAAEYLPQDLVFNIDYLGAQQSSFTLNFSKGASQVIGQYYQLIRLGKQGYRLIMSNLTRTADYLSDSLQKLGFIIMSKRAGEGLPLVAFRFPEPNEGGREDRHYDEFTLARQLRSRGWVVPAYTMAPNTNKMKMLRVVVREDFSRSRCDVLIHDIKICLGMLEEMDRETIKRQEEYIKTHLTSSGRAQESIHKPRHFKDDDHSLQGKTGKTHAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTA5</accession>
    <name>A0A7D5YTA5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540907.1">
        <property type="nucleotide sequence ID" value="XM_014685421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTA5"/>
    <dbReference type="GeneID" id="26246213"/>
    <dbReference type="KEGG" id="mbrn:26246213"/>
    <dbReference type="OrthoDB" id="5098383at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13704" checksum="ACD97F341B435404" modified="2021-02-10" version="1">MLEKIRQGFGYHHLRISDPVSSAIFFHREIKAFLKHYVRMGEPSVFGKVSKYYATIETNKWGALYLHGLMWLHGNTYLPTLLEDAYREEEEEYQRKIYKCIDDVFYEVGAKYAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTY5</accession>
    <name>A0A7D5YTY5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-cyclopiazonate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cpaO_0</name>
        <name evidence="2" type="ORF">G6M90_00g064020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540139.1">
        <property type="nucleotide sequence ID" value="XM_014684653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTY5"/>
    <dbReference type="GeneID" id="26247175"/>
    <dbReference type="KEGG" id="mbrn:26247175"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028991333" evidence="1">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="460" mass="51843" checksum="6EF5768B0733CA9C" modified="2021-02-10" version="1">MKLITFHASWLSIVITISASDPLFDSNYAKQDIIFRDVAVIGGGATGTYAAINLRKLNQSVVLVEREAILGGHTNSYTDPATQTTLDYGVQAYWNLSVTRDYFAHFDIPISNWEPEPKTTVYIDFMTGKQVEVRTSSNYSAYIQQLDKYPWLEYSWDQGHPVADDLVLPFRDFVAKYNLVDIAYTTYFSCQGFANVLDQLTINVIKFFDKSYIGALTGDYVATKQHKNDEIYVRAKAELGQDALTSSTVIASKRSKTGVQLVVKTPSGKKLIRARKLLISMPTRMSDMKPFDVDGKESKVFSQWKYSAYYVMLVHKTGLPAGYKFLNADPSTTRFNIPQLPAPYQITETRVPGLFYVWYSAPKDMTQSEVQADVTTIIKRLQDTVNGATKISPEFVRFNSHTPFKMVVSAESVINGFYSELFDLQGYRSTWYTGAAMMSHSAGVLWNYTSHLLPEMIAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV74</accession>
    <name>A0A7D5YV74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g044310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547765.1">
        <property type="nucleotide sequence ID" value="XM_014692279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV74"/>
    <dbReference type="GeneID" id="26240328"/>
    <dbReference type="KEGG" id="mbrn:26240328"/>
    <dbReference type="OrthoDB" id="5416037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF6">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="330"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="610" mass="65848" checksum="6331B8E9C70EA8E3" modified="2021-02-10" version="1">MSNASETCEPLQDPEVPANGQHAQNDDQASVTPAEAVEDSCEVAKGAQGGPSPGIVDDSNNSVASNHIPSASASSSPLEIISPRPSPHAPSSTVMPATVDECFDEDDPGAQLDAADTPPSSFCVTTPPINETPLSPSALDKDVESDKPEMNTQEDQDEQPPCQVGSPDISAPQSTNHIPSQRRPSVMDYLISPDSTKNSTSTSEASGPSSHRIANGYTWSDHGQAGHQPRPNGHPFVSSSHQGDDRKSQLSWNGQQSSFRLADNPLSIHSDYGSEVPYRGGYAQPYDRGGSSAPRSNASVAQSDVHPDQHTGTFYPEFANHLETMAPSGYHLLAAKLSGGAGGQPLVPIYRRFDALNHRLLLYMQDEIAELERQLIALEAQDTAKRSYLGGVIPASRRQDRWISNNLTDQKTEVLGHIGYKLSQYNQVLASFRKVQDIPVPTWRDIHLYKTYLTTSNLIVDDETRFLDAENDLVSLSGPMQSADDLNTVDDGPTPMPKATEEQQQFPPFFKDNGISSTRAEQATPQRQGDTVLVRLALSCMCVVFVPVITFAVVPNFIARMAIVVFVALSVGVMIEQSGLLAETGRHKLAWILYSGLYCGAMAVVAGTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWC1</accession>
    <name>A0A7D5YWC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g082420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987333.1">
        <property type="nucleotide sequence ID" value="XM_066131201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWC1"/>
    <dbReference type="GeneID" id="90968060"/>
    <dbReference type="KEGG" id="mbrn:90968060"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12748" checksum="82A2A7FD2EBA5781" modified="2021-02-10" version="1">MGRIALCAMHALQTDWKDGAKCDSSACMHTVRRIWHHAMATPPLHHLLPADAKRQPDCRMTQVNGWQQNANLLCIPWRPEEPVYKVKYTHNASLPDELKPATRYFYIHACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWL0</accession>
    <name>A0A7D5YWL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial transcription factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g047650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544882.2">
        <property type="nucleotide sequence ID" value="XM_014689396.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWL0"/>
    <dbReference type="GeneID" id="26242223"/>
    <dbReference type="KEGG" id="mbrn:26242223"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="63377" checksum="F179521C36E0CEC8" modified="2021-02-10" version="1">MLSVTSDIAHQLNLTGVWKRTGGRKKADAIRAVEPRRVNIVSEGLCDDVIRYIAPSLERHRGCDLVDLNPGAGVWSRKLHEFLEPRKHVMMDLDAELYKPFLSDLISKDNVELLPKSGLVWKDLLGMLHTSLSDQQEISQKDTPSRNDTLLITANLSMFPKKAFHGFDSISSMVLYQFISSISTSALFQRYGLVRMLIWVNDEDKRRILPRSTNRRKKSAFEAELSCEWVHEVAGLDAEVEDRNALRDEWINMESASQTLERMKAAGLSMPKGRETLVYSKLQREPALLGQKLAGARPPSLTRPFKQELELLEQGLSESAESSKRLKALRQRGKYDQKDALMYLGLLQERDTVAKLAASSPTEFERANAAWNEKIDNLTKNSRNEFNGIKDSYHLFRQSPPALLWDRRAYEPLSAKGEEFFPNAPTALLDIQPKAMHPVFRQHGPNSSRSGDMSEVMLRFWFHHTLLPIQKAMEGLWGGFGDLFAECPSVRDPSRGGTPMTGNGALTVRAMNADQWAEIMEAWMNWPFRPSYTQMLGRLVEEVDGDGDEEDTKSGATGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWT1</accession>
    <name>A0A7D5YWT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysozyme</fullName>
            <ecNumber evidence="11">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LYS</name>
        <name evidence="13" type="ORF">G6M90_00g111180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="11"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543744.1">
        <property type="nucleotide sequence ID" value="XM_014688258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWT1"/>
    <dbReference type="GeneID" id="26243131"/>
    <dbReference type="KEGG" id="mbrn:26243131"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028808745" description="Lysozyme" evidence="12">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI74400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="24231" checksum="AD4DE29E9B154AD3" modified="2021-02-10" version="1">MKSVAFFAVLASMANLATATVAGFDISHYQPNVDFKKAYADGARFVIIKATEGTTYIDPSFSSHYTGATQAGLIRGGYHFAHPGSGSGAAQATYFLAHGGGWSRDGITLPGMVDLEYNPSGSTCYGLSASAMVSWISDFVETYRSKTGVYPLIYTSTSWWNQCTGSSTAFGSKCPLVVARYATSVGTLPAGWSYQTIWQNSDKAPWGGDNDIFNGNLDQLKRIANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXD9</accession>
    <name>A0A7D5YXD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-erythrulose-4-phosphate isomerase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">derI1</name>
        <name evidence="3" type="ORF">G6M90_00g010720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549447.1">
        <property type="nucleotide sequence ID" value="XM_014693961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXD9"/>
    <dbReference type="GeneID" id="26238891"/>
    <dbReference type="KEGG" id="mbrn:26238891"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="16397" checksum="9E1845EC3ADBBFD0" modified="2021-02-10" version="1">MSPTWRIVMGCDEAGVSYKDAIKRDFESDSRVTEVIDVGSKESSDKTAYPLRAAAAARIVAEGKADRALLICGTGLGVAIAANKVKGIRAVTAHDSFSVERSVLSNNAQVLCMGERVVGLELARRLAKEWLAYEFDTTSASAKKVDEITSLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXJ3</accession>
    <name>A0A7D5YXJ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g096980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987554.1">
        <property type="nucleotide sequence ID" value="XM_066131520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXJ3"/>
    <dbReference type="GeneID" id="90968162"/>
    <dbReference type="KEGG" id="mbrn:90968162"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5281" checksum="12EE46E4FC166171" modified="2021-02-10" version="1">MMQTGKTQDSQLLLLLGFEHGSFLSAGLEGRQGRQAADWQTCVGETAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXY8</accession>
    <name>A0A7D5YXY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthetase dtxS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dtxS1_2</name>
        <name evidence="8" type="ORF">G6M90_00g081000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987481.1">
        <property type="nucleotide sequence ID" value="XM_066131168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247769"/>
    <dbReference type="KEGG" id="mbrn:26247769"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="588"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1679"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2751"/>
            <end position="2827"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4304"/>
            <end position="4380"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="5406"/>
            <end position="5482"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="6964"/>
            <end position="7040"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="9620"/>
            <end position="9699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="10158" mass="1118435" checksum="90973731F1EEA28D" modified="2021-02-10" version="1">[encoded data, 10158 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY87</accession>
    <name>A0A7D5YY87_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 family protein MCP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ABCP2</name>
        <name evidence="3" type="ORF">G6M90_00g010860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549434.2">
        <property type="nucleotide sequence ID" value="XM_014693948.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY87"/>
    <dbReference type="GeneID" id="26238878"/>
    <dbReference type="KEGG" id="mbrn:26238878"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="177"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="599" mass="66894" checksum="432F0393628D6DA8" modified="2021-02-10" version="1">MSALTIPRIATRLGPRTWTCSACQGQLAVANSHPFGGLRRFASARGSSQGANGNGRRGSRSRRVLLFASASAAGVASTALAFTDEIRNSYESMERTGRVVAALAICINDYRTTLNAKATIQDEEEQTKVLQACHKRCAERTFKVLEKNGGIFIKLGQHLSAMNYLLPPEWTTTFVPLQDKCPVSSFASIEDMFRKDTNGELWDIFSEFSSEPIGAASLAQVHLATLKESGRKVAVKVQHPDLEAFAPLDLALTKYTFSTLKRFFPEYDLEWLSSEMEVSLPKELDFQEEADNAMRMKAHFAKMPELPLVIPEVIWAKKRIIVMACESGARPDDLEYLDKNGIDRDEVSATLARIFNEMIFGDGAPLHCDPHGGNIAIRKNNARRGIGRGPNFDVILYDHGLYRDIPLPLRRSYAKMWLAVIDGDMDRMKKYSHEVAGIGDQDFPLFASAITGRDFSVVSNQGSILQTRSADEEQNMSSSLQEGLIVDLVQMLSRVPRIILLILKTNDLTRSLDESLQTRQGPIRSFLILARYCTRTVFHEQLEQIRNKGSLLWPPNGLRVFAAWLGYLRVEVKLEAFELWLGVKRVLGLKVDFAGGSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYG0</accession>
    <name>A0A7D5YYG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gna-3</name>
        <name evidence="14" type="ORF">G6M90_00g024990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548082.1">
        <property type="nucleotide sequence ID" value="XM_014692596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYG0"/>
    <dbReference type="GeneID" id="26237526"/>
    <dbReference type="KEGG" id="mbrn:26237526"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <begin position="153"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
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        </location>
        <ligand>
            <name>GTP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="272"/>
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        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="355" mass="41041" checksum="BFF859969991B0A6" modified="2021-02-10" version="1">MGGCMSSNSEEAEQKKKSQAIDRVIEEDSKRLRKECKILLLGSGESGKSTIVKQMKIIHLKGYSEDELYNYRPTVFKNLVECAKAVITAMQQFDIEPQLEENRRHIEYLMEYQAESGPQAHIDPQVGAAIQSLWADPARERLMEHQTEFYLMDSAEYFFQEVLRIVAPDYLPNEMDVLRARTKTTGIYETRFQMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLLLFDSVVNSRWFMRTSIILFLNKVDIFKQKLTRSPLGNYFPDYSGGNDVNKAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILNNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZE8</accession>
    <name>A0A7D5YZE8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ subfamily C member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DNJC7</name>
        <name evidence="6" type="ORF">G6M90_00g018570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548683.1">
        <property type="nucleotide sequence ID" value="XM_014693197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZE8"/>
    <dbReference type="GeneID" id="26238127"/>
    <dbReference type="KEGG" id="mbrn:26238127"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
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    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
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        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
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    <dbReference type="InterPro" id="IPR011990">
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    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
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    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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    </dbReference>
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        <property type="entry name" value="JDOMAIN"/>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
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    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="746"/>
            <end position="775"/>
        </location>
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    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="198"/>
            <end position="231"/>
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            <begin position="232"/>
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            <begin position="429"/>
            <end position="462"/>
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    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="555"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="194"/>
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    </feature>
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            <begin position="678"/>
            <end position="713"/>
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        <location>
            <begin position="466"/>
            <end position="493"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="791" mass="86990" checksum="E9DCEB933DF7A9EE" modified="2021-02-10" version="1">MKFFGGSKKQSSTSTSSSRKHTPSSSVDDRDFLQHQTHPHSEPASPTKGSSNNKSPSKRSSRPVSYREPKDPAPEKSSSSSSSTPRHARLSRHSTEPSSTSSSRRSKFDPDTHPLNLPPEERRRLSKLSNSTMSDHMDIDREPVNGASSPASQPQSNPSAQANFSVPIPNGTHHNDAPAPPPHRSNPSSPVPTALDDAEAYKAAGNRFFKDKNYTKAIEQYSKAVDLFPDSPTYLSNRAAARMSNGQYAAALEDCSRAADLDPQNSKILLRLARIYTFLGRPEEAMTTFGRITPAPSAKDMAPTKEMMYHVDTAKHILKQGTGVTMALHAIDQAERGLGPGVLKPRKWQLLRGDAHLLVGRENNLGEAQGIAMALLRNNAQDPEALVLRGRVFYGQGDNTKAIQSFRMALTCDPDYRDAVKWLKTVQRLDRMKEEGNVEFKAGRFQAAIEKYSEALQVDPNNHSINAKLLQNRAQCKIKLKQYNEAIADAEKAVSLDPSYLKAKKTKANALGQAGNWEESVREWKAIQEADPEDRTIPKEIRRAELELKKSLRKDYYKILGVEKDCGPDDVKKAYRKMAIKLHPDKNLDDPDAEAKFKDLSEAYETLSDPQKKAAYDNGDDLMDPADMFGGGGMGGIDPEILFSMMGNQGGFGGGGFRSAGGFPGAAGGFPGGAQFNFANAGGGRSRGESEEEEEEQEAVQWDTDASDSRDANVPEDHATAKEELMHEYQQRRDARNNLVDTLRQYGMLVLAAVVLLPPHLAVAAVFCMLLVYMLMRYVRPSSRTATKPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZM8</accession>
    <name>A0A7D5YZM8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g018020</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985899.1">
        <property type="nucleotide sequence ID" value="XM_066129810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZM8"/>
    <dbReference type="GeneID" id="26238175"/>
    <dbReference type="KEGG" id="mbrn:26238175"/>
    <dbReference type="OrthoDB" id="4961608at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028926187" description="CFEM domain-containing protein" evidence="12">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="13">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="218" mass="21154" checksum="E0E9309BC2133F65" modified="2021-02-10" version="1">MKNSIIISLSALGSLAAAASEAPCLSLTTNFPTCVLSCAQEAASKAGCTNTADLECQCNPKSSSAIQGLALGCAAACSATELPAGISAGRALCECVASHAAATTSGTETGTETGTETTGTETTGTETTATGTPHTGALTSEITRTQTSTGTKTGSESETTTTTGTQTETSTTTEATTSGATTTSPTTATQTTTTAGAGIFQVSFAVVAGAILVAAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZM9</accession>
    <name>A0A7D5YZM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g035310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546925.1">
        <property type="nucleotide sequence ID" value="XM_014691439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZM9"/>
    <dbReference type="GeneID" id="26239488"/>
    <dbReference type="KEGG" id="mbrn:26239488"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="325" mass="36539" checksum="F31C338FA0940B57" modified="2021-02-10" version="1">MHPLNPAVDDGQLIHDMRFNLASLPHSPASLLPEGVWLEDVPGTPLCASSDEVASHSTLDATGAQPHRPPYVDSCSRPEAETDNGCVVCPVDRTNETDDHVDNEDQTDGCHRNTPDRSSMVTMLLRSSAPLERLPNEVLLHILGFLDVSDLLATSRTSHLLRSLSLAPILHHYRLRRTRQVLPPLLSSPTRPTVAELISRSIFLTHTSVVSRRLAWSLVSIRLSRRLAARPSAEALVQRCVLPKECVPGMSSVLIAPALVAKRKAVEKEKVKDELRRWIAAKWKGEVREREEELRRWHESRGVGRVWKLTKFWERVSRGDHRPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z061</accession>
    <name>A0A7D5Z061_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AAT2</name>
        <name evidence="10" type="ORF">G6M90_00g023190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548236.1">
        <property type="nucleotide sequence ID" value="XM_014692750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z061"/>
    <dbReference type="GeneID" id="26237680"/>
    <dbReference type="KEGG" id="mbrn:26237680"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="75"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="454" mass="49095" checksum="331757FFDEC4D7B5" modified="2021-02-10" version="1">MAPPSSSSSSSSSSASPSASPSSSSSLARINNIANHISPAMASATSFPADTVPQAPEDPLFGLARAYKADQSSLKVDLGIGAYRDDNAKPWVLPVVKKADEILRNNPELNHEYAPIAGIPDFTSKAAELILGADSPALQEKRATSIQTISGTGAVHLGALFLAKFYKGNRTVYLSNPTWANHKQIFGNVGLQVADYPYFSKKTNGLDFEGMKAAIQAAPDRSVILLHPCAHNPTGVDPTLDQWKELAVIIAQKKHFPFFDCAYQGFASGNLAQDAAAIRYFVEQGFETVVCQSFAKNFGLYGERAGCFHVVTSPGPDASTTISRIGSQLAILQRSEISNPPLYGARIAATVLNDPKLFAEWEDNLKTMSGRIITMRNELRSRLEKLGTPGTWNHITDQIGMFSFTGLSEAQVLKLREDYHIYMTKNGRISMAGLNSKNIDHVASAIDKVVREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0I2</accession>
    <name>A0A7D5Z0I2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP_5</name>
        <name evidence="6" type="ORF">G6M90_00g077580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545344.1">
        <property type="nucleotide sequence ID" value="XM_014689858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0I2"/>
    <dbReference type="GeneID" id="26241377"/>
    <dbReference type="KEGG" id="mbrn:26241377"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028948317" evidence="4">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="103"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="364" mass="38570" checksum="976E5EB57D7CD5B2" modified="2021-02-10" version="1">MRLPELPLARAALALLSMRLAPSAASPVQLDGTTLGLINTYSRYATAAYCPDLQDLSLNSAVCSNPSAHACGATADATTVEEFGNAHSISGYIAVSKSRPVIVVSFRGTDIWNVRDVMSDVLACLKDPKLRWTFLGVFTDAICALLPSQAADKADKLLPLCDGCRVHQGFWAAFTGVKDRMMAVVQEQLARNPGYSVVATGHSLGGGVATLAGAYLRKGGVRTDIYTYGSPRVGNAAFAEYVSDGRGGRTVRVTNRHDPVTAVPGDRSAGYAHTTPEFWFPEGLGRPSRICEGVHNLSCSGGIFDLLCLGDHDGYGYANGVDVCPGKGGKTLGPTLRDIIRQEDVDEWVRFGILDNTTAPDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0K0</accession>
    <name>A0A7D5Z0K0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g009580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549556.1">
        <property type="nucleotide sequence ID" value="XM_014694070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0K0"/>
    <dbReference type="GeneID" id="26239000"/>
    <dbReference type="KEGG" id="mbrn:26239000"/>
    <dbReference type="OrthoDB" id="3763672at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF3">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46627" checksum="E7AADDF0E67BC9A7" modified="2021-02-10" version="1">MLNNSVRSTKGMAILVGAIFFVAAFVGLVYNHLDSWNLPVRPHTQHSQPRPSTTDDNSTTPIQRPSPDSKTPAAATSSDDELRKFFLKQMYKPALTPDQPFFKPYNAFEWRLPEAAHWQQPMGENLCIIDLDNRLFNESGQVFGPDVMDWDSPKGVHGLSLGLLNHYVYARIHGYKYYYINTVDPGDRRASWKKPPVISKILKEHDVCIYLDSDAIFHYLDLPFEWLMNYWRLYPDTNSMALAVDPDTDWNKDRFGKLYLNTGFIISQNNPMTYKIMDAWNKCPDDDSPYPECKEFRLNAPGRPTDQGGFGTFVRYNYTEHIRELPCTEANGFPQTDSGCNGIFVRHLWTGKDDQIKIDVGTQMPGPYLKLFHEQYLKEKPTFYIGQEDLLRLGPSQALKGKSVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Q0</accession>
    <name>A0A7D5Z0Q0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g108550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543991.1">
        <property type="nucleotide sequence ID" value="XM_014688505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Q0"/>
    <dbReference type="GeneID" id="26243378"/>
    <dbReference type="KEGG" id="mbrn:26243378"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="411" mass="46550" checksum="D2C621797656D825" modified="2021-02-10" version="1">MEKPSDHWQGFASLAPGSDRYKRIQLLSSANFEYLKARGIESRKKHQPGLPSDVKCSVNLTHFTSGFNNVVFELAFSDNVYWIARIPHQCQTESDKTSLASEIATMKMIQEHTTVPIPQVFDFQTSADQPFGYPYVFMEYLGGRTLPNGLARAIPSQHHNKVARQLANVFAQLQNLTFSRIGRLWCGENADQPVKIIPMAWHATPGPLETSLEYFYNQKQDENREAISMHPDDPNWRTACWVLKTALTHMIIEDRVRGPFPLCHLDLHFGNMLFDNDYNLTGIIDWSSAQAAPLEQLSVCPEFVTFPGLSAEENQPIVDLKKLVVESIMKMESNQEWRPPMDNPGANMVLKANMTRLSTYMASKSAEITHRHYMASSRKSLFGGKAVAKLIYGKSVTWEQLTEVYGTMPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0T5</accession>
    <name>A0A7D5Z0T5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g005620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542207.1">
        <property type="nucleotide sequence ID" value="XM_014686721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0T5"/>
    <dbReference type="GeneID" id="26245238"/>
    <dbReference type="KEGG" id="mbrn:26245238"/>
    <dbReference type="OrthoDB" id="5062850at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="608" mass="68815" checksum="8007A160A0738091" modified="2021-02-10" version="1">MAPASQLHFLDLPSEIRHAVYNAYVDVDGGYVVNPRTNKLVTATGNQKHDFALQLTCKQIAREMSGLALGRNTLHFKVEYSDEERISAARFEATLAISLVRLVEFLSPDEEGGVDFTQDIEDEVVAEFPPMQPVFDAIDGLPDTYGDLQVSVAEDFAIPLSVFFKAGWRTFGLAVEQGSIPKTHSMLSYSDAERAYAASQEFCPWHYNPSRKDFTRMFGKARMIRRQGYRYWLKPHLDANGMRQFTQGKYRFSAASKAIRFLSQCPEQLRMQLRRICLHETSHSVAFPECHALGLIPYCQENPRLYVERRVNIWRTLLQTTYTDSCILSWTPENDWLFYTNPEHHGGEESANGARLASYRITRVFSRWAMEALELVRSGMPRRSFKLVFDGDPAPQLATRLFRDLIQRDATWQRVLEASWGGVEEQHPTVDMSCIRSHQGGYSFDGFPDMVDAIASNTHELIECAFETGPNPWDETALSRQFHYFPPGLERLEAACQTFADQPAQFFDLPHPLPSWTGLLAENILPEYFDPDTELDQVEAVDLYNVLEDVESDANEDDLVTDNTDTSDDEDDAATSDDEGGSDGESPPGDDSEAEKDARSYDGSETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0W3</accession>
    <name>A0A7D5Z0W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g071270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545932.1">
        <property type="nucleotide sequence ID" value="XM_014690446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0W3"/>
    <dbReference type="GeneID" id="26241965"/>
    <dbReference type="KEGG" id="mbrn:26241965"/>
    <dbReference type="OrthoDB" id="5310497at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="31205" checksum="ECF33E9AE51D2AFF" modified="2021-02-10" version="1">MRYSIVFAAVAATTVSGHGVIRSIAGANGVIMPGLGVADGTPRNCVVNSCGAQADTCIIRDNEIASGKYGPLGWTQGSGNVDPNAVIANFMGKGNAPPRNKGASDSVGVEDNLQGLLTPKERRDNEMNMMGNLFQGIANLPIVGTLGFGGSRKTYPTETMNADMRGQGAKSGLPTADENGIVNVVYRQINQDGAGPTTAAVDCESGGKDPKKFKTARVVRDVPGSGISGLSIATNTDYAMQVQIPQDCACTGEAGGVKNVCILRIRNQALAGPFGGAVAFTQSKASHKRALEYRLQKRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0W8</accession>
    <name>A0A7D5Z0W8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat-labile enterotoxin IIA, A chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">E2AA_1</name>
        <name evidence="7" type="ORF">G6M90_00g027040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547882.1">
        <property type="nucleotide sequence ID" value="XM_014692396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0W8"/>
    <dbReference type="GeneID" id="26237326"/>
    <dbReference type="KEGG" id="mbrn:26237326"/>
    <dbReference type="OrthoDB" id="4928190at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00771">
        <property type="entry name" value="ENTEROTOXINA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028804809" evidence="6">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="666" mass="74234" checksum="E8B0693911F3247D" modified="2021-02-10" version="1">MKASPWVSIAAPLLLFGLCQGHLKPGHSFEPTLERRGVDTESGGFDDEFPRHVYRGEIQRTPKEVQKDGGFYSRGMQRILSGDKLSWEELEDGSSLFRHAAGDTAPFTRYVSTSADPATSLTFAVNDEDPVEKGYIYKIHADKRMVDVNRSLGKYSPYPAQTEHAAIGFIPFEQIEGWWEVTYKHDFADPKVGKKTQDKLRRGQLKHFHRNPHFSPNFQKLRGNGVAPQLAGFPRLSTAWDEDTWKQFKTLPVSKSLDDMIEAVCTGNGNDNCIKQLGQPQSKPTKPKTSPSGPIDPAKPKSLATSFRVYAKAGTLVGFNVLAPYLRNVLNQLRQWDHPIGWAVKELDDSINGFQEYIGGPRRNDISGNDNQAALINFFKRVFWILEGPRRRPQDLQLLSYGKRNKMRLISVNDVLRTCERVDETPPDEQQLKTNLKDACTKVRKKAMELEMPTAAELEIGRAACGVCGLAWSPQDGQCKDKTGAILWPREPPAESTCTHHDSTKCGGEQTAAQLQTGQAVCGICGSNWYPDEGKCRDAAGVLLWPFKTCSAGAGRIQCEGGQTTAQRETGQAVCKACGKYWDPEGSKCRDEAGMLIWPPQHLPSIKPLHPSEKCRGGNDMTCQRRQIAAEAERGRIVCGTCRFSWDLRARKCRDNSGAVIWPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1G3</accession>
    <name>A0A7D5Z1G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neuraminidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g045800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544708.1">
        <property type="nucleotide sequence ID" value="XM_014689222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1G3"/>
    <dbReference type="GeneID" id="26242049"/>
    <dbReference type="KEGG" id="mbrn:26242049"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041079">
        <property type="entry name" value="Neuraminidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18413">
        <property type="entry name" value="Neuraminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neuraminidase-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7850" checksum="CD0E1F71ACAADF78" modified="2021-02-10" version="1">MEGDIQTHEVDADQKPLAHPGGYLLPALFKKRLFLFIPQIARQEKKGEDQKQSLADQANDVDGPSKAEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1U6</accession>
    <name>A0A7D5Z1U6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">srpA</name>
        <name evidence="15" type="ORF">G6M90_00g065670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540206.1">
        <property type="nucleotide sequence ID" value="XM_014684720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1U6"/>
    <dbReference type="GeneID" id="26247015"/>
    <dbReference type="KEGG" id="mbrn:26247015"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="522" mass="56625" checksum="86A60A8C9C9C1569" modified="2021-02-10" version="1">MVLQDLGRRINAAVTNLTRDQNLDEKAFDNMLKEICAALLEADVNVKLVMQLRKSIKSTVNFKDLPPAVNKKRLIQKAVFDELVQLVDPHAEPFKPKKGKPNVIMFVGLQGAGKTTTCTKLARHYQTRGFRACLVCADTFRAGAFDQLKQNATKAKIPYYGSLTETDPAAVARAGVDQFKKEKFDVIIVDTSGRHRQESALFQEMIDIQTAIRPDETIMVLDASIGQQAESQAKAFKEAADFGAIIITKTDGHAHGGGAISAVAATHTPIVFIGTGEHMLDLERFAPQQFVQKLLGMGDMAGLVEHVQSLNLNQKDTIKHIQEGIFTVRDLRDQLSNIMKMGPLSKMAGMIPGMSNMMQGMDDEEGSAKLKRMIYICDSMTDKELDSDGKILIEQPTRMTRIARGSGTSVREVEDLLTQQRMMAGMAKKMGGNMRNMQRAQQAMGGGNKAQQMAAMQKRLQSMGGAGGAGGMPDMGSLMKMLGGGGGMPGGMDMQAMMRQMGMGGGMPGMPGMPGGSGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2H8</accession>
    <name>A0A7D5Z2H8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g056100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986808.1">
        <property type="nucleotide sequence ID" value="XM_066130613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2H8"/>
    <dbReference type="GeneID" id="26242615"/>
    <dbReference type="KEGG" id="mbrn:26242615"/>
    <dbReference type="OrthoDB" id="4939936at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="534" mass="59205" checksum="6AD93384B627EAB4" modified="2021-02-10" version="1">MPQAAHDIFKGIQGLYPRLGTLFPVPFPEDRTPLSSSPASSWMRMEPKSTPELRDLLAQLAQFLRANESRISAEQVSKCLQHLSAMELSALNRLFCLLYQTKKRGAPSRPDASGTSSPPSVAPLNNTNTNNNNNLDANRPRPSRLGDAPSAAGNVRQGDSCARSPSSTDRPRNTRHSDGHHQPSPSPDASHQAETTTLHAGADGDTFVRTDLATCNEIKFAASTKQLLENCRTDRGEFLRAIREAKAALPTGHGWEAAIATKKENADIRDMMRIYHRFECHNIYSHVVEAGFHTGTHWIREMRTVLVNKLCKDFPERFQNQKTANKCLNWVDQGCRYREWTDLLSETSDLGYLLALPADVPHSAYTSRCTKEQMTAAALRFKSLGIDKLVEDLELSELGNHISAKLREMTGKKRKDADEELNQNSRKSPRLTPSSGAGELGLVQPAGQLTTPPESMPAGIGDLFGHPTHCVMPPLAQEYSGHQERDREHHNTIGTMVDSFLAPYDPFNNFDMSLQAYSEVFLSQFSVVSSSTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2M0</accession>
    <name>A0A7D5Z2M0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TM234</name>
        <name evidence="7" type="ORF">G6M90_00g011360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549386.1">
        <property type="nucleotide sequence ID" value="XM_014693900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2M0"/>
    <dbReference type="GeneID" id="26238830"/>
    <dbReference type="KEGG" id="mbrn:26238830"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16375" checksum="A674262A1E2EEACE" modified="2021-02-10" version="1">MQDDKPPVINYVVSFILVGLAWGLTTPFIRRAARAHHPPPHPTLHLDSVKNHWLRSRLYGAFFAVADLLRNPRYALPLLLNLTGSIWFFLLIGHAELSLTVPIVNTMAFLFTVLGEWYVEGKVISRDTGVGMVLSLVGIALCVQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Q3</accession>
    <name>A0A7D5Z2Q3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SNX3</name>
        <name evidence="14" type="ORF">G6M90_00g083820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543599.1">
        <property type="nucleotide sequence ID" value="XM_014688113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Q3"/>
    <dbReference type="GeneID" id="26243776"/>
    <dbReference type="KEGG" id="mbrn:26243776"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI72404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="142" mass="16594" checksum="0B1FF3044C244B79" modified="2021-02-10" version="1">MQAMPDTRQQSFDEIYGPPENFLEIEVRNPRTHGIGRSMYTDYEILCRTNIPAFKLRQSSVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2S1</accession>
    <name>A0A7D5Z2S1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">noc3l</name>
        <name evidence="9" type="ORF">G6M90_00g087600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI72444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542356.1">
        <property type="nucleotide sequence ID" value="XM_014686870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2S1"/>
    <dbReference type="GeneID" id="26244870"/>
    <dbReference type="KEGG" id="mbrn:26244870"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="126"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="477"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="665" mass="74950" checksum="D8C57570F36900C5" modified="2021-02-10" version="1">MVANGNKKRKITHNSSDDESHAPTTSKRAQKDFFKHASNWNLEQDYESRPRKGKKNEKENTKLPIKSQDGRLELLKGLDPDDDAASIESDTEWLEGRDGGVESEDEEVVEEIKAAEVPEAQRILEAQEELAKAAMALNENPEENIGNLKTLAQIGRSKIPTIRMLALMTQMTVYKDIIPGYRIRPQSEDAPKEKLSKEVRNTRQFEQSLVAGYQAYIKELARCARSETTPVRSGQSLSNVAVTCACTLITSVPHFNFRSDILRILVGKLSRRKIDKDAAKIIQALETLFRDDEEGRPSLEAVSLITKMMKAKEFAVHESVLNLFLSLRLLSEFSGKASQDTVEQQRAPKTKKKREFRTKRERKAMKEQKSLDKDMSLADALVSHEERERMQSETLKLVFATYFRILKQRSPHLMGAVLEGLAKYSHLINQDFFGDLLEALKDLIRHSDEDAEQGPADEEAAEKEDDEESVRNLTREALLCTVTAYALLAGQDAHNSRNDLHLDLSYFTTHLFRSLLSLSLQSDLENTRLSTSSATSKINVQTTTVLLLRSLTGILLPNYNIRQVPPLRLAAFTKQLMTTALQLPEKSSQAILALLNDVAHTHSKKINSLWNTEERKGNGQYNAMSDSVEGSNPFATTVWEGELLRKHFSPKVREGVKMLEKGMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2W9</accession>
    <name>A0A7D5Z2W9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g062430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687149.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2W9"/>
    <dbReference type="GeneID" id="26244584"/>
    <dbReference type="KEGG" id="mbrn:26244584"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="424" mass="46228" checksum="A816D1CA6C640A08" modified="2021-02-10" version="1">MDGKRNIVIIGGGIIGCTTAYYLTRHPKFNPAIHTVTLLEAGPSLACGASGKAGGLLALWAYPACIVPLSYKLHAELAAEHNGAQKWGYRKLQCGSFEAVVSRKKLSKPNQPQLSTDGEKPWEKLPKQDEAAQELLEEGILPKDLDWVDRDLVTSWAEMGGPGTTETSQVHPFHFTTTIGELAKQAGVEIRTDVKVTKVATSKTAVERVEYLDRSTGEMRDIKDATDIVVTAGPWTGRLLPRAKVEGLRAHSVVYDAEVSPFAVFTDIQLPSDFVPEHRAKLGQQRMHKSHVDPEIYARPFGEAYACGEGDTTTPLPDTVDQVECDEARCDDITSYISTFSPVLAAAPIKAKQSCYLPRHMRFGQESGPLIGQTTVPGLWVAAGHTCWGIQNGPATGKLMSEYLFDGVAKSANIDKLDPRKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z332</accession>
    <name>A0A7D5Z332_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689835.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241354"/>
    <dbReference type="KEGG" id="mbrn:26241354"/>
    <dbReference type="OrthoDB" id="5364312at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42111:SF1">
        <property type="entry name" value="YALI0D23727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="379" mass="39479" checksum="253C2D5D3A88A84D" modified="2021-02-10" version="1">MSLAESPTLKRGERFPRGSDVADDSSFDDSTPHAVKETDSDPNMENQKGAKVKKRSLFGFGKKKEGSSSLTAGSDTVPTSPVASQPSKTSPTTSKITASPTRVHTGEHCVFVHPSSPGRALSSSPRVSSPAGSQIFERDVQDSTVLKPNSPAIPTHIQTENYIPPVLDDASEAITNEKLDPDAVEIVTHTSHQPASVTVTGASGGLASPYDQMASEWAAELASFASRVGLPPDSASNYGSLDSADVRRLSFISFADVVQAEHGNQAGGPGSRDSLHMVGLTSLPSAALNRSPSPIRSPVSSQGQGTSPPTSNPGSMKGVEMSPTRKPFGSPKPGQQNLAAPGGDLNIETMRQALRRTGSADLSSFRSNPTSPLDGPGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3K2</accession>
    <name>A0A7D5Z3K2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g066760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539543.2">
        <property type="nucleotide sequence ID" value="XM_014684057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3K2"/>
    <dbReference type="GeneID" id="26247626"/>
    <dbReference type="KEGG" id="mbrn:26247626"/>
    <dbReference type="OrthoDB" id="3759600at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39221" checksum="AF8264226DD312A3" modified="2021-02-10" version="1">MEIEPDCIISSESFDKYALDERRRTSNERVQDFLDRGLMSQVVVYQRFTEELSERLTSFKRSDQPAVIEDIRHLFRRLCDPKNGYLSEAAFKRLVAERLSEFGVNKSSNAPALLFKVCSSHAFYPFPASNSGSEQAEIDEDSFVRAVCLLTLSPAQRHGNQVPGTVHRCSSGIWGPHDGWYIAIRGKDASDFRRRLFRSIALPASSGTSTSYDTKITVPRFIWFKSENEETDFGPEPDQQVVVTEDESELLIDIIDVLSECPPEADRLTANPFRESYCIVLPSLPKRIGDLSMLFIPRMELVALLELVHQVQGENLVDLAAAIRGLGNEEKISWKRFDSAMSEQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3K3</accession>
    <name>A0A7D5Z3K3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Modifier of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NCT transcriptional regulatory complex subunit mot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">G6M90_00g014320</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its C-terminal ATPase activity. Both transcription activation and repression require its ATPase activity. Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms the NCT transcriptional regulatory complex with nctA and nctB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549090.1">
        <property type="nucleotide sequence ID" value="XM_014693604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238534"/>
    <dbReference type="KEGG" id="mbrn:26238534"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000508">
        <property type="entry name" value="Probable helicase mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000445">
        <property type="entry name" value="Related to MOT1-transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="1317"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1662"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="178"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="691"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI65569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1895" mass="210670" checksum="1C274E0CC7A914FB" modified="2021-02-10" version="1">MASRLDRLVTILETGSTRLIRETAVNQLADWQKQHPDELFNLLSRVVPYLRHKDWETRSTAAKAIGKICENAPLYDPNEDDGPSEPKKEENAGENGHIKKEETDKENSLTGHDHDLLKFESLDVNSILTYGRELLRGGGIEYSLASLDPQARLEHQKKTLLGRLGLLGRRFEDEEMPVVAQSQTLPVTPIDGSNGNGLARSDSISQSQGGEDSQLSSRQLNVLKRKRKREAMKASQGKGGFGDLSLRRSTTAGSESLIGDETPMAEGESKKNGKMNDYFNLDRPTDVDEDTKVVSEFKGPVIPIKSELEVEDVLEGAEWPYERLCDFLKIDLFDPSWETRHGAAMGLREVIRVHGGGAGRVRGKGRYDNESLNKRWLDDLACRLCCVLMLDRFTDYSSDTSVAPIRETIGQTLGSALKHIPSKSVHDIYRILYRMVMQEDLELERPVWAVCHGGMVGLRYVVAVRKDLLLQDGDMIDGIIRAVMKGLGDMDDDVRSVSAATLIPMAKEFVTMRPDQLDGLTSIVWESLSNLGDDLSASTGRIMDLLATLCGFPEVLDAMKASAAQDEERSFTLLVPRLYPFLRHTITSVRLAVLKALLTFANLGDDTSHGWLNGRILRLIFQNILVERDQETLNMSLELWNALVGSLAKNPAILADEFAPHIDSLMELTLHPIGISRNPIPMNATLFQKPSGGTYSAQGMAPPAGRRLSSPDGADRAPKRRRKSTKTEEPISTGMTHDVDGHMMQGDVDLVGMDVLIRSRVSAAIAMGKIMSLVPSSNLDDFDALLVPGLTSAFSSTQLSACLVIDEFAKNCTSPNEPSRYTEQLQRMVELDRPSSYRDLVNFVQRARTQCQQLIHLFRDHGKVSHGKLPVLPVVVQGEPEAGPNAFSIATAEKCVGDDFERLKKIMPPGQRLIASQQLSEARNVAEAAIEEAKAFKDARDTRIRAGAACALVAMRLLPKKPSPLIKGVMDSVKTEENQLLQNRSSATIARLVQLFAEKGRKGPADKVVANLVKFSCVEVAETPEFPVHATKTSCILSMQKEEDRVDHPDAAKWAKEAKAARITRRGAKEALEILSKAYGSTLLETVPSLRKFMEEPLVKAFTGDLPAEAKDPESVFGQEIVDAMSVIRTMTPTLDVALHTFVMKMLPLVIKALHSELSVFRYMAAKCLATICSVITVEGMTALVEKVLPSISNPLDLNFRQGVTEAIYHLIAVMGDAILPYVIFLIVPVLGRMSDSDNEIRLIATTSFATLVKLVPLEAGIPDPPGLSEELLKGRDRERTFIAQLLDPKKVEQFKIPVAIKAELRSYQQEGVNWLHFLNKYHLHGILCDDMGLGKTLQTICIVASDHHQRQEEFAKTGAADVRRLPSLIVCPPTLSGHWQQEIRTYAPFLTVTAYVGPPAERKAIRDKLGETDIVVTSYDVCRNDTDILGKHSWNYVVLDEGHLIKNPKAKITQAVKRLASNHRLILTGTPIQNNVLELWSLFDFLMPGFLGAEKVFLDRFAKPIAASRFSKASSKEQEAGALAIEALHKQVLPFLLRRLKEEVLNDLPPKILQNYYCDLSDLQKKLFEDFTKKQGKKLQSEAGRDDKEAKQHIFQALQYMRKLCNSPAMVMKPGTPVYDDTQKILQRQGTSVEDTIHAPKLTALKDLLVDCGIGSDDGDTNDPLYQPIKPHRALIFCQMKEMLDMVEKKVLKELLPSVSHLRLDGSVEANKRQDIVNKFNSDPSYDVLLLTTSVGGLGLNLTGADTVIFVEHDWNPQKDLQAMDRAHRIGQKKVVNVYRLITRGTLEEKILSLQRFKIDVASTVVNQQNAGLSTMDTDQILDLFNLGDSGPNLISEKAQKEVDGREEDMVDIETGDVLRQPGKKAWLDDLGELWDNKQYEESFDLDDFMKTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3V3</accession>
    <name>A0A7D5Z3V3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g090920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541746.1">
        <property type="nucleotide sequence ID" value="XM_014686260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3V3"/>
    <dbReference type="GeneID" id="26245609"/>
    <dbReference type="KEGG" id="mbrn:26245609"/>
    <dbReference type="OrthoDB" id="4941236at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028965901" evidence="2">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="270" mass="28484" checksum="56289AAFDF1693FB" modified="2021-02-10" version="1">MKAIVVLSALVAVQAAKTTPRPTTLDNGEFVSPLETCDDSCKSSFARPSEHVKTIKSKFKTKTKATTVSPSAEPDLSTALDLGPGTAFPPYVSSPDCTQTTTVVGATHPAVVTPLSTTSSKQGKDKDKDKGKGSKTEHSEAPSPTSPLEEEPAITTTSVLWKDCGTCALFWTTAQSTYVPRVTVANPTDYTYTITQVSCLTIAQAESTGTMLTELPETTEAASTELPEPTDEVPEPTDEVPEPTDEAESTELPDTTVPISIELAEPSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4D0</accession>
    <name>A0A7D5Z4D0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat, bromo and BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g022970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986101.1">
        <property type="nucleotide sequence ID" value="XM_066129899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4D0"/>
    <dbReference type="GeneID" id="26237702"/>
    <dbReference type="KEGG" id="mbrn:26237702"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46992" checksum="88F3906B40F65633" modified="2021-02-10" version="1">MSSEANAGSVAATADKAEKPKFSWLRPHPIFVIILVGSEEQPFGIQKDFLCHRSDFYRKYFAGNQTEDTVEHVVKLADATPEVFGLAQNFLFTGKVMSGDEGVPSYDSLVGLWNLGHKLGVNGLCDKTLEAMTECRRLTERIPSTPLLVQVWRDTPEGSSIRMLLLSWAAEYMRSSDSRAEFAKSLPQEVLSELVVAMSSFELAAPTPAPAPAPASAPSHSPVVSAPELPRKNVHYLEDQSEDDLNNIRKNRRLSGPPTIIARTDQSLGRKASRTPLPKPQKRRTSAAYVDSRNFSTGQKLEFCADLLTRMLSGPGFWTRLVGPFRDPVEPAEDGVPDYFDKVKRPMDLTTIKAKMDRREYATEDAFVTDMRQIFENCYTYWKKGDPMWLAAEKLQKTFEDKFSHMNKWIAKMGGEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4K5</accession>
    <name>A0A7D5Z4K5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mpp</name>
        <name evidence="14" type="ORF">G6M90_00g056570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544248.1">
        <property type="nucleotide sequence ID" value="XM_014688762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4K5"/>
    <dbReference type="GeneID" id="26242660"/>
    <dbReference type="KEGG" id="mbrn:26242660"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
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    </dbReference>
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        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
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        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="304"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="557" mass="60438" checksum="B82FB2B1F08B6027" modified="2021-02-10" version="1">MLRQLSARLSPTTRFLARGNAWRRGMATEPTELDQITTLPNGLRVASEALPGSFAGVGVYVEAGSRFETPSLRGVSHIMDRLAFKSTSSHTADAMLERVENLGGNIQCASSRESMMYQAATFNNAVPETVSLLAETIRDPNITEDEVAEQIETARYEIAEIWGKPELILPELVHTAAFKDNTLGNPLLCPEERLGEIKRDTVLKYREAFYQPERMVLAFAGVDHGVAVRLAEQFFGDMKSTSLPGAREVTGSETESDTDSASSSSSYTSASSSSSATPRTHIMSKIPFIKNLSTSAPRNAAVLNNLPADIAAFPAHYTGGFLSLPAQPPSLNQTNFTHIHLAFEGLPVGSDDIYALATLQTLLGGGGSFSAGGPGKGMYSRLYTNVLNQYGWVESCVSFNHSYTDSGLFGISASCLPGHTSAMLDVMCQELRALTLDTGFSRLQEGEVSRAKNQLRSSLLMNLESRMVELEDLGRSVQVHGHKIPVRDMCARIEALTVRDLRRVASMVVHGTLGNPGRGSGAPTVVVQEAQAYGLTSHSMTWDQIQDRIDAWKLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4N9</accession>
    <name>A0A7D5Z4N9_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g052910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684932.1"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="137"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="822" mass="91363" checksum="CDA7B5402E9B041C" modified="2021-02-10" version="1">MLPSSLKSIYQQYKADTDSVANWLAKTANANGYQDNASSSNNVLAKSGRVKGKARKQAKASGQPQPGNLANKTSRIIRVRDFEPMASHIAKLDSVKVPHDLSVALERVIWVRKNFLKRLLDSGAEIEPGSDTGSFNADEAAEKAGEKSQEAFKNMFDVLQVYAPSESFLNAPDVAPKSATVLEYTVEQDESMEDAIFALVTLLGDYSRLRQEVKSLWADYEANRLDLAAAAVATNMAFELARSMEDEIAPIIRKHDGEAGELATTYFMGLCNLYGIDPGDKQPGDAYNLQAYDLAELCLATTNTLLTSYATGTSPTVVINYYNGKFGWYNEELGAKGKTSRAKWDQDKNAMLEILPDLHFLASNMGTGAVEDELIRGIGALMRDPDGVTPLWLSFAAQIYLDVLQSLGSNCGRGFDEMKQESLKIKKAMLNVPSSPERSRVLKAATKWDKDPIRACRDQMVKLGQLSGTMPPAWRFLRRNPIHCGLLIHNMRVNLHLSGVAYAATPGAVMCTTQLYQALRQEKLLSDQLVWEDVETFWKMQGDSAFFVGDPPKNREGYFKNYCLCLGVSVSNWAPTKRKGKVNVNTANRRNMKFNGWVSLVINRRLAPTGERLPLSSDLIEGILIEGRRHETMDGKGHIQPEIKGKAKDEPIDAVSLPPAALIRRLALNIHAEIPDIRFNYFTMHHSAWRFLTELKEEFTRLWGARFLQYIPTEDKLPYVVGYVFSTAAGQKGLTSDDKGEAVDAGIDAAAKVMRKFLEDGHGRVVKEQVETEVEPEELKDADFEGFSDSWRLDTLMKKLKRESQAGRGSGRGGAEEDCHMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Z4</accession>
    <name>A0A7D5Z4Z4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBX domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UBX5</name>
        <name evidence="3" type="ORF">G6M90_00g092460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686404.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245358"/>
    <dbReference type="KEGG" id="mbrn:26245358"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="461"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="543" mass="59616" checksum="DBB7D6ACFB16CB0F" modified="2021-02-10" version="1">MDESISSFVAITGATADVARGFLQIVNGDFERAIGLFYENPELASGVGAGIAEPTSGPANPTSSSGRRPNIGHEGASGIIHISDDDDDNDDDDDVMMVDDARSGDDGERAAVQHAAAMAQEEEDAAMAKRLQEELYQGNSAGPGAPDDVRAPIARTTETLVAPDPAWDGAVDDETTQRFLEQLRNRRHPPPRSGGPFAQRIWGDAAGVTPPSATENGTHARRLEDLFRPPYELMARVSWDEARTLGKEDKKWILVNLQDMNDFNCQALNRDIWKDAAIKELVSENFIFLQYDKDYPDAEEYITFYFPNRTHENPDNYPHVSIVDPRTGEQVKVWSGRPFPTAADFHAELAEFLDRYSLAANSKNPVAKSTTRKPAVVDVDRMTEDEMLEMALKNSLAAGGGESSRSTSTPNIQDPDAFTKSPGPSDGVGDGGKGKEAEVAPEQTVFALISSGKPHTEPENNPATTTRIQFRHPTGRVIRRFNLQDPVRRIYEWLKAEPMPGKDGVEFELKKMPQGQDLIGDVDSTIEETGLKQGTVMIEFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z515</accession>
    <name>A0A7D5Z515_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division control protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CDC31</name>
        <name evidence="5" type="ORF">G6M90_00g039440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547298.1">
        <property type="nucleotide sequence ID" value="XM_014691812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z515"/>
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    <sequence length="215" mass="24925" checksum="5AD3E9C9C58228BE" modified="2021-02-10" version="1">MNPHATPRPFPGRSIGPSSLQHQFQQNQQNQQPQPQQQQRQPLAPQVSANEEYASIADEDREHIDEVFDLMDMKKKGWLNSYEFKHSLAALGFDLSKPEYFRELQSYGSVPPDWHDQQSCPVNRYYVYLDQFRLCAAKLIANRDPREEAAKVFAMFDYDQDGFISVEDLRHLAQEIKDERTLSDEEIQSMIDHLDHDGKGGVSLDEFMQMMEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">4556</strain>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
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            <position position="158"/>
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        <source>
            <dbReference type="EMBL" id="QLI73105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="345" mass="38478" checksum="772E32AE2521EE80" modified="2021-02-10" version="1">MSNLFSGINARFRGASTKPPGQKSPSPSTGGPPVPADTASQGSQSSTNLAPKVPPLPNSPSLAQTIGMDASSSGMSNAEDIINNYHLPRPLPLWLNAQYVKHIVKGNFMTLSARPKTVEQGEWIAHQVVEHYRNLWNFVRVVHEKEDDGTSICNPTTCPRMSAGANHSFTWLNNRREPVELPAYEYMTLMQRWISGKIDDTAIFPTDPSGVSYAHNPSITTTPLSQLSNPGEAEYIGKRSGFPEKFLEVCQMIFRQMFRVYAHLYWAHFTEPFYHLNLEKQLNSCFSHFILTATALDMLKPQELEPMQALIDLWAANGTFPPESKAYEYANLRAGERLLHLAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6D6</accession>
    <name>A0A7D5Z6D6_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
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        <name evidence="13" type="primary">pkar1</name>
        <name evidence="13" type="ORF">G6M90_00g103990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to stress"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="CNMP_BINDING_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="128"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="260"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
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        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="215"/>
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        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
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        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="42203" checksum="CA48DE7F4D166632" modified="2021-02-10" version="1">MSVPFSSPFGANANPFGNDRSQNVMHSLAEEDENENGRNQTTGIGPGAGISFAGTFGGDASTDTPPTVRGPPHPDSYPAQYNFARRTSVSAESLKPSADSYDNWSPPFHEKTADQLGRLKRAIEGNFLFSHLDEEQTAQILGALVEKPIPAKGIKVISQGDAGDFFYVVEKGSFDVHVNPSGTIQPGPDGLGEQVGNIQAGGSFGELALMYNAPRAATVISVEPNCTLWALDRITFRRILMESTFARRRMYETFLEEVPLLSSLTPYERSKIADALETKKYAPGEIIIREGDPGHSFFLLESGEADAFKGDQSNKVLHYKKGDFFGELALLNDQPRAASVMASTEVKVATLGKNAFQRLLGPVEGILRRTRYEGVATGVEEMDPLHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5Z6W6_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">G6M90_00g070430</name>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="26246508"/>
    <dbReference type="KEGG" id="mbrn:26246508"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028880613" evidence="1">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="81" mass="8902" checksum="9579C824B08B9CE8" modified="2021-02-10" version="1">MVPSATLFSIFAMLAAASAQASSSWKPAKNQLCFGRQSCHYASDEANKRQGNLMSHIFPDEVCIRGKINPESWVDRIPKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7C0</accession>
    <name>A0A7D5Z7C0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g053370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7C0"/>
    <dbReference type="GeneID" id="26246824"/>
    <dbReference type="KEGG" id="mbrn:26246824"/>
    <dbReference type="OrthoDB" id="4933407at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
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    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29295" checksum="20FFBBA75C6DDCCC" modified="2021-02-10" version="1">MGSSHSSLVTSVSAVPSATALVPGQSAPTIFPSSTLHSAVVFSDDFEGSAPQFNHSRYRVDGSGSITAVTNPVFHGQQSAKFTVPNDGVSWRSEIAKNSLGYGSFSFSFVNYLPTDWVDTSVNTIVAQWHGFQLTNGQNTNPPIALSLKDMRWLLVVHHLENPSDSKPKARWYDLGQTTKGTWNQWDFRIDWSRPELNGTVTVILNDKTVAVHKGSNNYHQTEAPYFKQGIYRPNWNPEKGFSYLTGGPSVVVYCDDLVVTKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7D5</accession>
    <name>A0A7D5Z7D5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LIP5</name>
        <name evidence="1" type="ORF">G6M90_00g094000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="26246377"/>
    <dbReference type="KEGG" id="mbrn:26246377"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="GO" id="GO:0004806">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF1">
        <property type="entry name" value="LIPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="136" mass="14528" checksum="240DC3A629967F12" modified="2021-02-10" version="1">MGKHVMGVYKNETPVAPVFLYHAPDDEIVPYHDAGILVDRWCGYGASVDFLTVAAGGHFTTEILGVPDAVRFTANALEGKLAAGCSTRTSYNDTLNPIALGAQLEPALASLLQMLANLGKKDASIKQDLTKLGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7X6</accession>
    <name>A0A7D5Z7X6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g112760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684857.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246937"/>
    <dbReference type="KEGG" id="mbrn:26246937"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="336"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="697"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z956</accession>
    <name>A0A7D5Z956_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Dctn5</name>
        <name evidence="6" type="ORF">G6M90_00g078210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545287.1">
        <property type="nucleotide sequence ID" value="XM_014689801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z956"/>
    <dbReference type="GeneID" id="26241320"/>
    <dbReference type="KEGG" id="mbrn:26241320"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="193" mass="20637" checksum="37AAC644641C6868" modified="2021-02-10" version="1">MSRRPAKGDYIETDTGNKVARKAILVGTQNIMLGGKTVIQPEVMIRGDLVRTAPSSSSAPTSSTAVAIGRYCFLSRGVLLRPPGRLYKGVYTYMPLRLGDHVFVGQNTVVQAATVGNHVSIGRDCAVNEFAIVKDYVKILDGSVVPSSMVIPSFSVVAGRPARVVGELPEGALDDFELRDMYKTVGNNPQPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z977</accession>
    <name>A0A7D5Z977_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g102150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546131.2">
        <property type="nucleotide sequence ID" value="XM_014690645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z977"/>
    <dbReference type="GeneID" id="26240554"/>
    <dbReference type="KEGG" id="mbrn:26240554"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26398" checksum="1F1B649D8AF0FC55" modified="2021-02-10" version="1">MPATANTTNDDAASEFWLYGYGSLIWKPPPHFGSGLGQWLCQEILAGMFEETHTLVIQVTPAFESLLTYTYILLHQASEDHRGTPEAPGRVVTLIERSYWEKLTDHHDSAPEKVWGVAYRIVPEKVSEVKEYLDIREINGYSIHYTPFYPADGSTPMETLVYIGTPDNEQFVGPQDPQKLAQHILNSKGPSGLNRDYLYGLDTALNELSPDSGDYHVSDLAQRVRALEHSVNGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9G5</accession>
    <name>A0A7D5Z9G5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc-regulated transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZRT2_1</name>
        <name evidence="10" type="ORF">G6M90_00g056320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544225.1">
        <property type="nucleotide sequence ID" value="XM_014688739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9G5"/>
    <dbReference type="GeneID" id="26242637"/>
    <dbReference type="KEGG" id="mbrn:26242637"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="40294" checksum="4ADFF1FFBD9CC970" modified="2021-02-10" version="1">MAEEEQQSSCDGSPVDLGMLGLRIASIFIILVASLVGALTPILLARQTKMHVPKFTFFICKYVGTGVIIGTAWMHLLDPAVDQLGDACVQERWLGTYPWALCIALMTIMVMFFVELMVARFDDDDDAAHSHPTGSDSGSDLNEVLAIKKSSKPQKDKNVQAEPCPHDIENQGALCGPDPTAIPGRPDDVSYPPGGEDHLAHRHDHKEGDSHTSLSGQLTAIFILEFGVVFHSVFIGLTLGTTGSDDLKVLLVVLVFHQMFEGLGLGSRIAVAEWPESKQWLPYVLAVGFALSTPVGVAAGVGAKPANAATQKLVNGIFDSISAGILMYTGLVELLAHEFMFNPHMRRAPLKIQLFAFGCIAFGVTVMALLAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9I9</accession>
    <name>A0A7D5Z9I9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fusaridione A cluster transcription factor fsdR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fsdR_1</name>
        <name evidence="4" type="ORF">G6M90_00g079400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986947.1">
        <property type="nucleotide sequence ID" value="XM_066131132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9I9"/>
    <dbReference type="GeneID" id="90968030"/>
    <dbReference type="KEGG" id="mbrn:90968030"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="665" mass="74800" checksum="CDC5D6FB9E700694" modified="2021-02-10" version="1">MTARVDNHALGRSPRRKACDLCFTKKIKCDMLQPTCSNCILYKAECTTGKGRRKPNPPARVRAAAIQHHQQPQYTTANTDKTEDRLARIEKQLEQLIALQASRPADTTGSWSSSQCEQGGDSAMTLSNADFDVAFPSRDPVVFDSASTKFPLAMDLAPRDELPLPPQADVMPIVDHYFDTYAYIMPLFDQKSFMSMLYQWYTDPSTRNKASWAAIQVVLAIALRTPIPELLNGCGGSDRHHRANFFLKNAQSVVSDLVTRDKDLLGLQVLLGIVMLFQNSSDTSPASVIIGTAIRLAHRMRLHSRDHAELFSPDENLQRQRLFWIAYVLDKDISLRIQVPSVQLDSDIDIDVPPAQPADDVGVLWTRDRQTCFNHHRSMIHLAQIQGRVYDWLHSNSSAKMSRQSRQQRVQQLDRMITHWYSTIPAAFNLENLDASIGECALIHMAKMYHVYLLILVMTYGIYNQDSNWVQAIRSGDRNAIRSLVLGTERHDSGAASQKQVRLLPGSWHKVVQVSRGCLRLFDMCIPTECLIWQCSCPHFSGMMVLLANLLIEPTHEDAVSDEILSARAIQLFDKVLELIPDPEHYTDIRGIIEELYNRAVLVINEAKSQGGDDQVDVLEANLLSYETLDGDPWSWAAALPGRTDFSADMRDGDGDSLGVLPLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9X2</accession>
    <name>A0A7D5Z9X2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g085430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987528.1">
        <property type="nucleotide sequence ID" value="XM_066131272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9X2"/>
    <dbReference type="GeneID" id="26246089"/>
    <dbReference type="KEGG" id="mbrn:26246089"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="191"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="714" mass="80030" checksum="46E10DAC33B6C81B" modified="2021-02-10" version="1">MIRGAGIVGRKPNGPGLQYPLGFTIVKYLDIVLYQGLSSLITIWDALGPQLPPVVMVMSSSLCPQAMNGWDQAKDSVFTFHHSKAARNEHLEEKGITHTEQVDMQQNLEARIRNPLQGIPRSQLMQDVENFAQRKGLQDHVALLKKGALVAQDPTNIHNIDGPEKLSSEELEVLGDEVTHKWRMPLRLFLTIFTCSIGAAVQGWDQTGSNGATIFFPKYYGIGGTSDRETIIVGLINAGPYIGSALIGCWLSDPLNNWFGRRGTIFFSANFCIWPVIGSALCHTWEQQLACRILMGIGMGAKASTVPIYAAENSPASIRGALVMSWQMWTAFGIMLGTAVNLAVYKVAGPLNWRLMLGAPFIPAVPLMALIYLCPESPRWYMKKGRFQEAWESMSKLRRNHIQVARDIYYISAQLDIEKEVIGNTNYITRVTQLFTVPRVRRANLAAFTVMIAQQMCGINIIAFYSTSIFEQAFRNDSNPQFKAMIGSFGFGLVNWLFAFPAFFTIDTFGRRSLLLFTFPQMFWTLLAAGLCTLIDAEGSMAEARTGLVCLFVFLFGAFYSPGEGPVPFTYSAEVYPLSHRETGMGFAVATCLFWASVLGITFPFILNRLQTIGAFSLYAGFNVVAFIMIFFWVPETMQRTLEELDWVFAVPTSKFAKYQLTVALPWWFKRYILFQRNATKEPLYHFEKVAMNTGKDAFANQAMVPSSDDERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBV5</accession>
    <name>A0A7D5ZBV5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g082820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543504.1">
        <property type="nucleotide sequence ID" value="XM_014688018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBV5"/>
    <dbReference type="GeneID" id="26243681"/>
    <dbReference type="KEGG" id="mbrn:26243681"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058:SF1">
        <property type="entry name" value="DUF427 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43058">
        <property type="entry name" value="SLR0655 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17426" checksum="D61895F1245C75EA" modified="2021-02-10" version="1">MNVQSFPRPPRLEKISRHLLVVYKGQTIAETKEAFWALETHHPPTYYLPPSSVRIPLATTAKKTFCEWKGFATYYMAQLSDGKTVCNRIWSYDQPASPFEPIQGYLSFYAEPWECFVDGEKVEPQPGDFYGGWVTSEIEGIVKGRSGNLDPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDS5</accession>
    <name>A0A7D5ZDS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g105160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987774.1">
        <property type="nucleotide sequence ID" value="XM_066131668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDS5"/>
    <dbReference type="GeneID" id="90968203"/>
    <dbReference type="KEGG" id="mbrn:90968203"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20212" checksum="4137B663D73F416F" modified="2021-02-10" version="1">MRAVGVQGENLAIILFHLYLAINTNTRKTAFWVLTYLLHNPELLAAYRRETAPAFRGPDLADPSVIQDAARCPEVDAVWHETLRMSGWSASVRFVTRDTVIGGKRMRKGSRILVPHRLLHFDEGIFGDATHQFRTERWRNNKNLPRSPSFRPFGGGKTMCSGRFIARFSVTIFVATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPG4</accession>
    <name>A0A7D5UPG4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g008780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549632.2">
        <property type="nucleotide sequence ID" value="XM_014694146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPG4"/>
    <dbReference type="GeneID" id="26239076"/>
    <dbReference type="KEGG" id="mbrn:26239076"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6643" checksum="8727BBF42C26D505" modified="2021-02-10" version="1">MARGNQRDKAREANLKKQAAQKKGNAMTGNEMQRAKESAAEIMRQKQAAAEARKAEAGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPL2</accession>
    <name>A0A7D5UPL2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C-like</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">G6M90_00g019020</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548638.1">
        <property type="nucleotide sequence ID" value="XM_014693152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPL2"/>
    <dbReference type="GeneID" id="26238082"/>
    <dbReference type="KEGG" id="mbrn:26238082"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="24">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="24">
        <location>
            <begin position="150"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="20">
        <location>
            <begin position="233"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="462"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="530"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="819"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="23">
        <location>
            <begin position="1079"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="352"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="597"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="652"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="602"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QLI63553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128094" checksum="27A9C2AB1A515655" modified="2021-02-10" version="1">MTEDEKKIQDIYKKIEREKNIINAAQAMRSQTTNEAVRSRLDTQLRDGRRNLQFFEEKLRDIQMRQVNQDMGNVSLGAGAGADDGGPPPPPPKDPSAAWGGDQGGYGTAQYSQGGQHGDLMPPRHPYAPPGPGAGMPKSRPNFTKLDLIKYDTPYLGPRIQLMLSQIQFKLNVEEQYLKGVEKMVQLYGMEGDRRSKAVAAGRRVESKQKIVLLKQALKRYEELHIDMDSADAQDDDSINTPNLRKPLSGQLSIRVMAVKDVDHAATGRLSRGPETFVAVKVEDAVVARTKTSRTDRWDAEYHTIDVDKANEIELTVYDKPGEHPMPIGLLWVRISDIVEEMRRKRIEAEMNSSGWVSADQMGTPSSPPGHLPMSPTQTGFGSQGHGADQSSGYSGGPPPHVPQPQINTGPIDAWFNLEPTGQIQLQMSFVKQNKDRRPVDLGLGRKGAVRQRKEEVHEMYGHKFVQHQFYNIMRCALCGDFLKYSAGMQCEDCKYTCHTKCYDKVVTKCISKSNAETDPDEEKINHRIPHRFQPFSNMTANWCCHCGYILPFGKKNCRKCSECGLTCHAHCAHLVPDFCGMSMAVANQILEGIRTQKRQTKASSMSERTLRPSSSKPGSTASPAPSYTTDASKPYTAPSTAATEAAKLMYAQPTSPTQQRPPAPDRLPSTQAAKAAQAALGGTTAAQAQQQRQSDYGRYGGYDQEQPDDHYSQQYGGQPQQPQQPQQPQQPQQRPYNPADYLGYAGQPATQARPPVQQLPPQQQPAPPQQSYQPPAPVPKPEVVVAHRPQSGPIAGQPKQLPLATDPGTGQRIGLDHFNFLAVLGKGNFGKVMLAETKRSRRLYAIKVLKKEFIIENDEVESIRSEKRVFLIANKERHPFLTNLHACFQTETRVYFVMEYVSGGDLMLHIQRGQFGTKRAQFYAAEVCLALKYFHENGVIYRDLKLDNIMLTLDGHIKVADYGLCKEDMWYGKNTSTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPEQRLGSGPTDAQEVMSQPFFRNINWDDIYYKRVAPPFKPTIKSATDTSNFDSEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPV0</accession>
    <name>A0A7D5UPV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate permease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cys-14_0</name>
        <name evidence="7" type="ORF">G6M90_00g010240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549493.1">
        <property type="nucleotide sequence ID" value="XM_014694007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPV0"/>
    <dbReference type="GeneID" id="26238937"/>
    <dbReference type="KEGG" id="mbrn:26238937"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="557"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="786" mass="85384" checksum="0B5BCFB6BA40CB44" modified="2021-02-10" version="1">MTSTPSIKGRLAKAVGYDSDGRDDDVPSISNADLFIEEEPTIGEFLAEITPSLQNVINYFVNLFPFVRWIGKYNLTWLIGDLVAGITVGAVVVPQGMAYAQLAQLDVEYGLYTSFMGVLIYWFFATSKDITIGPVAVMSQVTGNIVLKAKDELPNVPGHVVASALAIITGAIILFLGLARLGWLVEFISLPAICAFMTGSAVNIISGQVPKLMGISGINTRDAPYLVIINTLKGLPNTKLDAALGLTALLMLYLIRGVCSFMSKKQPHRAKMYFFLSTLRTVFVILLYTAISAGVNVSHKKKPSFSLIKDVPRGFQHAAVPEINAPIIQAFASEIPAAVIVMLIEHISISKSFGRINNYVIDPSQELVAIGVTNLLGPFLGGYPATGSFSRTAIKSKAGVRTPFAGVITAIVVLLALYALPAVFYYIPNAALAAVIIHAVGDVITPPKVIFHFWRVSPLEVPIFLAGVLVTVFTTIENGIYTTIAVSAAVLIWRLFLSRGRVLGVARIRTAKADQELKHAGDSAFAEESDESLRKGFLPIDHADGSNPRVVVQSPHPGVYIYRFAEGFNYPNATRYLNHLTEVIFAETRRTDPTLLGKIGDRAWNDNTPRNQDVDKVDTRPTLKAIILDFSSVNNIDVTAAQALIDVRNQLDRYAAPEAVDWHFANIENRWTKRALAAAGFGFRSPRPAHGSGVANWKTIFSIADLGGSDSAAKAAEAAAIGDKKSVREYDIEQAESDISRLSDKDVPQNPGSARLVAIQGLNRPYFHFDLQEAVESAIANSERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPX4</accession>
    <name>A0A7D5UPX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985626.1">
        <property type="nucleotide sequence ID" value="XM_066129606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPX4"/>
    <dbReference type="GeneID" id="90967427"/>
    <dbReference type="KEGG" id="mbrn:90967427"/>
    <dbReference type="OrthoDB" id="5036585at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028944285" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10864" checksum="C515A771B65AE29D" modified="2021-02-10" version="1">MRLLLLPLFASTAAAQGVVSATVYSQPNFEGLLRNVIGFGCVNLDDVGFKIESIELRHQTFCYAYGKVNCAGTSVYMSRSVGDLWRYLTTESAHCFDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ42</accession>
    <name>A0A7D5UQ42_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539967.2">
        <property type="nucleotide sequence ID" value="XM_014684481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ42"/>
    <dbReference type="GeneID" id="26247187"/>
    <dbReference type="KEGG" id="mbrn:26247187"/>
    <dbReference type="OrthoDB" id="10303337at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="210" mass="23024" checksum="8DEF1F8628664BC5" modified="2021-02-10" version="1">METETSLTAPPNTPEKNPYEGVCQRKVDAQSRNLDPTSCKSFYLAHEIIEISSESDGNSDEATVPNSPRVIEEDINEGDQPSENASRADAAEDEVNDNTNKAKNGSIVYSNGLLATECLPNVDHARFANTAEESSSKYSIITMRLDTPASEKYGAVGQKFGEGGYVGNREGSSECSNGKLKRAYDRYESPPDDVPEHDLLSKRRRTAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQH0</accession>
    <name>A0A7D5UQH0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3',5'-cyclic-nucleotide phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cgs2</name>
        <name evidence="2" type="ORF">G6M90_00g018230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQH0"/>
    <dbReference type="GeneID" id="26238158"/>
    <dbReference type="KEGG" id="mbrn:26238158"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="505" mass="55133" checksum="126E07C3603A32D1" modified="2021-02-10" version="1">MGEVADPALQVIVLGSGGGPQESNITAFLVRSVAEKWSKGSIIAVDAGVHLSAITRLLQESYPSTPPTNLPFTLSTGAFAGLELPYASAAANAAHVTRSLVDTYLITHPHLDHISGFVVNTAGLPGTRPKKLAGLPSTIQAFKNHIFNNVIWPNLSDENNGAGLLTYLRLVEGGSPALGDGEGKGYMEVCDGLLVKTWSVSHGHCIERHPHRGSASSVSTRFGSHDASSQTPRRDIHYHTAMQPTPKATGLLSQAAFSAVSSTQFAASNEQEKICVYDSSAYFIRDQSHRREVLIFGDVEPDSISLSPRNLYVWQEAAPRIVSGILAAIFIECSYDDSQSNDRLFGHLKPGFLMEELRVLANEVEVAQKLGTFDSKKRKRSSMDEIMNQRRNPFGKPGFMYDDSVSPKSIKPTVPKQEATPDHADTPHLATPTDELSLHDFGPMDPILEKKPLEGLKVIIIHVKERLEDGPQVGDTILQQLQDYEKEMNLGCEFIMSKSGMSLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQH9</accession>
    <name>A0A7D5UQH9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">MED4</name>
        <name evidence="10" type="ORF">G6M90_00g019100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548630.1">
        <property type="nucleotide sequence ID" value="XM_014693144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQH9"/>
    <dbReference type="GeneID" id="26238074"/>
    <dbReference type="KEGG" id="mbrn:26238074"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="332" mass="37414" checksum="6256EE7F2E8ED581" modified="2021-02-10" version="1">MDKYIDGRFERLEKALSNLIDSVTKYHPSTIQAEELKAADNELSKGLEEVQIHQNNHLRIQKLRQSSAALDTQIRDTLTSLANTHKDIVSTHTTTYPSEPNYPIVYEELLRYARRISKTTLPPAATLEGAAASPETQSPNPESLAQSALTPSARTPSQPQSPAVNGTPQLTAEQPTQPPAANLNTSLPEGMSQYLNPLSGQLFFPWPLEDKIRSGSLASYQVLVEQDIDPKGYDPATEEERRLKEEEERRAKEEQEKAEREAREKQLREERERARAERERQREKEQAEWRRASIVSGQPDGPGLSRAGTALGEKKQFQFTNLDDLDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQY3</accession>
    <name>A0A7D5UQY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g007990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549709.1">
        <property type="nucleotide sequence ID" value="XM_014694223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQY3"/>
    <dbReference type="GeneID" id="26239153"/>
    <dbReference type="KEGG" id="mbrn:26239153"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF7">
        <property type="entry name" value="P-HYDROXYBENZOATE-M-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="426"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="72128" checksum="246D621B1FB49E8D" modified="2021-02-10" version="1">MTEPAVEGKPFQLYDIVIVGAGPVGLMLSTCLARWGYRVKHVDDRPEPTKTGRADGIQPRSLDLLRNMGLKTGLMAHKPARVYEVAFWNPDKSGNDIVRTGTWASCPKFIDARYPFTTLLHQGHIENVFINDLEKNGVLIQRPWTITHFESDEQENPEHPVRVELKHVDGTTTETVRAKYLFGGEGSRSFVRRLLNIQVKHIDPIQHVWGVMDGVVKTDFPDIKMKCTIHSHHGSIMVIPREDNMVRLYIQIASSEEPDWNPRKTATSEEVQETAKKILHPYTIDWERVEWYSVYPIGQGISDRYSLDQRVFLGGDACHTHSPKAGQGMNTAFLDALNLAWKIHAVEGGFAHRDLLKTYEIERKGVAESLLDFDNRYAKLFSQRPPAAKEVEAATEGCPANRGEAEEDDFVKMFKESCEFTSGYGVAYGPNEVNWSVNHQANSTLIHPEGTKLRTGHIFINSDVTRVVDANVVHLEQEIPLNGSFRIFIFAGNPAVTHTALQDLANGLGAERSFYGAYARKDVDTVSHHERHNPHSLFFTICTIFAAKRSSIEISKDVPRLLARYRDHIYADDIWDRRVPNSRASAHAKMGLDEERGAVVVVRPDGYVGVIVSLVEGSGTVNALNEYFSAFCSKNLVAGSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR77</accession>
    <name>A0A7D5UR77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein 6, OR allele</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">het-6_0</name>
        <name evidence="3" type="ORF">G6M90_00g004670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542115.1">
        <property type="nucleotide sequence ID" value="XM_014686629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR77"/>
    <dbReference type="GeneID" id="26245146"/>
    <dbReference type="KEGG" id="mbrn:26245146"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="269"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="839" mass="93799" checksum="2919E3617E7C3F7C" modified="2021-02-10" version="1">MSASPNAAPNQLAAALTALPPKIRTLIVFSALGLKAGVVALKDTILAKVCASVLSNIGLYGYYIPADTIFILVHMYLFFFGQTSWRTTALTLRRFASRDDADDDLTTKLFVEASELSFYVLLSFVFRNVGAIWSFACWSFSVLSQILAFICVPGIMWMIMVDNPVQNFNSEVTRIWNFTWPKILTGLGMAGGLVATAVRHCLRFLVKISASLVSYTDGKTAARVTTLKTYTYSALAPGEIRLLRLSKSTPWSPVQCKLVHVRLDEAVEFETISYTWGSRQTRKGLIVDGARLDVSDRVYDIVHDRASFLMTRHIWVDSICINQQDNEEKSSQVQLMRKIYGSSYHTVIWLGHGSDANDAVWFLSHLRRRIDSDETTRRQAMSLMELNIESPGWTALTRLVNHDYWARCWVIQEIAVSKKVIISYGGELITWDYFSSLMTTLFTGDPNHVWHISKIYWRTLDPLPMDAGVQIASLGRLREIIQANHSTQLFDLLISSINSTATDARDNIFAVQGISAAADTGDIMPDYNSAIERPFLRTAEYLLSKEHPSRILHLAGVGFHRNHNLQLSWVPDWSSKRLAGMLWRHPNSSSYRASGVVDEELKMMLGDDGLTLITEGVQVDCIKELGPQFFGVSENGVVKTEKFPGSFKNLADSREVALNGSLSAPYVTGISLTEAFWRTLVGDRTPSGTRPADPIFATYFQAVEGFIKTLRKCGPDMNPLNPSLSAEEQERLGSDITYYALDSGRFANVAGPHTRERMFATTERGYMGMIPPYSRVGDAVFIIPGAQVPFLLRRQRTADNGVSDLEGGKWQLVGESYFHGMMDGEMVPEGRVVQTMEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USB8</accession>
    <name>A0A7D5USB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g000780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542990.1">
        <property type="nucleotide sequence ID" value="XM_014687504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USB8"/>
    <dbReference type="GeneID" id="26244363"/>
    <dbReference type="KEGG" id="mbrn:26244363"/>
    <dbReference type="OrthoDB" id="5399485at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="515" mass="55676" checksum="086DB75449A3789E" modified="2021-02-10" version="1">MIITVMSTATVRVLLRVYFIVFIAATAWISKIALHILAKIIVARHRTVSATSAIGSLDGLDLVLTSFRLRRLAGGTVGFSILLLLFLLGKAADVLTAYLVVSKPVKDRCWFGQGLIFNDSVPNVYSQVNGRPVAVLQNAQIFAVNNTCPYGIYKKVNLDPSFCPDDKDIIGSWKCETTASLTLPAGTSNVTIINDLVSKKMLHTNWFDEYSGNTGAGSNTNHLVVWSTSAAANSDGSDWGVLAAVQKNWEPDEPVQLEALKCIMNAPGATNTAQSMASVYDLKIWAPTFQGLMYWGTNTPAVNNVADQLAMLLNTMVMISGGRNYLLATPGVRQDRTQGCVKPAAYVPPTMIALFLLVLALSLLSLLAFLTLFLWYRILKGNLPEDDVREIETVPQDVLEWALLAVRGHAYRARLPQPSAAVHNAQGHGNNGEEMEELYPVNLGENDLTAANGANMDMPLIQQGPGAPAAGDLGGVGDAAGVLPIEARELREFQIGLGQVDGEGRTVRIFRRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USL7</accession>
    <name>A0A7D5USL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrpl38</name>
        <name evidence="7" type="ORF">G6M90_00g018110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548725.1">
        <property type="nucleotide sequence ID" value="XM_014693239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USL7"/>
    <dbReference type="GeneID" id="26238169"/>
    <dbReference type="KEGG" id="mbrn:26238169"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="131" mass="14111" checksum="485D69A2F2C5000B" modified="2021-02-10" version="1">MIQLKTMLNCIDNSGAALVECALVVGQKRHARIGDRIVVVVQEQRGASSSGMAGISAAAKVKRGDIRHAVVVRTRYPTQRRDGSVVRFDDNACVLLNKSGDPVGSRINGVVGAELKRKKWSKILSMAPMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTI7</accession>
    <name>A0A7D5UTI7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g004100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985979.1">
        <property type="nucleotide sequence ID" value="XM_066129562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTI7"/>
    <dbReference type="GeneID" id="26245094"/>
    <dbReference type="KEGG" id="mbrn:26245094"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44441" checksum="429E2700641512E5" modified="2021-02-10" version="1">MPAAACGMTLPCLSIGWQASATAPTTSTNQRRAPLLCVVALGPWVGIVTQIIVSSSRSALTRRPPQSPLDSSIAGALASPEALEATTIGEFHPLLESLFRPGADSHEVQIPKTAAGDGQVRQRGRTDAKYKRECINAAHLFRKPHCLRKVPSEKGKACNRCVRNGTSCQYDADVGESRAAALKKKYSALEKEAGQLRKGVHQLQRLYGYICASSEDEAYKVFQHIRAGDNHNPIDALRLFDRNDVLALECTESPASTDMSDDTRVESASNALFEVRALPWSVVASDEVVSELISQYFMFDYLYVFPPIPRVTFVDEMKLGDVAAATSCSPLLVNAICAQQCFLSPRQHLDTTVREVLAERFLHEANRLLQSEGGRLSLPDAQAICLIYAAVAARDQVRSGVISHADEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU12</accession>
    <name>A0A7D5UU12_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">VPS11</name>
        <name evidence="14" type="ORF">G6M90_00g031680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543106.1">
        <property type="nucleotide sequence ID" value="XM_014687620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU12"/>
    <dbReference type="GeneID" id="26243907"/>
    <dbReference type="KEGG" id="mbrn:26243907"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="405"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="887"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="981" mass="109363" checksum="74E9111F6B71991F" modified="2021-02-10" version="1">MAISWKSFDFFEVSQVSLPDDETRSLFDANEISSICSGSDSLFLGGSDGSVSIISKSWKAVRTFQAHDAGRVTHMRQVEGTSLLITVAEDLSSEPVLKAWALDKLVKKTNMPTCLSTLTINNGRRQFPISAFAASDDLSQIAVGFGNGAVTVIRGDLIHDLGTKQRIVFESEEPVTGVQLATDEKLTTLFISTTTRIVKLGLSRKGQGLPPKTVEDSGCAWGCMTLDKETGDVVVARDDAIYTYSLDGRGPPKAYEAPKTLIAMYENYVALKCLPTGVNGRDPDSMRRRFGGGGNDDLFNATMFVLLEPDLRVIAHSETIMSPVRFIFDVWGDLYTMSEEGKIYRYHEKPLQQRLEMLYQRNMFPLAIELAQGSGMDSQQQSIIYRKFGDHLYQKADYDGAMMQYIRAIDTTEPSQVIRKFLDTQRIHNLIQYLEQLHEHRKATADHTTLLLNCYAKLKDIAKLEKFIRSPGDLKFDLDTAIVMCRQGGYYEQAAYLAKRHGETELVADILIEDSKSYGEALGYIWRQDPEVAYPCMQKYARVLIENCPKEATKLFIDYYTGKYRPRKSTVAIPGETSSTGGLTSGTSSAVQNLTNYLPFPYMGTSSGPTATPGTPSNIKQPASNGTLELGEDDHPPPKYTVPAPRTAFSSFIDHPDEFITFLEACLEEGDLKVSDRTDLYTTLFEMYLYKASEKKGHHREEWEGKAKKLIEGEHVPMESSNVLLLSDLSNFRDGTVLVKEQAGLLFDIFRSYTSAKDTRGAIKALRKYGPEEPQLYPAALAYLTSDPKVLEEAGPDELANVLSKIDKDGLMAPLQVVQTLVGQSSAGGVATMGMIKPYLHDTITRERKEIQDNRRQIDTLRVDTEKRRAEIADLGSKPAVFQATRCSDCGQGLDLPAVHFLCKHSFHQRCLRGGEGDEVECPQCAGGNDLIRKMRQEQRKAAEKHDLFKIELEGSEDRFGTVARWFGRGVMDGQNKDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV62</accession>
    <name>A0A7D5UV62_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxylase B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gloB2_1</name>
        <name evidence="3" type="ORF">G6M90_00g033260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    <dbReference type="OrthoDB" id="449487at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MBL fold metallo-hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
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        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="295" mass="32796" checksum="5AB6D314B694D46E" modified="2021-02-10" version="1">MDQKITVHDIHEPNTGTWQYVVADPSTMSAAIIDSVLDFDPASASISTKSADGLLALIKDKGYKVDLILETHAHADHLTAAAYLQDQLGKSQGSRPEIGIGKRIAEVQKRFGDRYGVKKDDYENAFDRLFEDEDEFKIGNMNATVLYLPGHTPDHVGYKIQDNIFCGDSLFNADVGSARCDFPGGDATQLYNSVQKLLSHGPHVKIWTGHDYPPEARAGRAISAMTVSQQREQNKHLKDGTSQDEFVTWRSERDATLKEPRLIHYALQINIRAGRLPKPTTTGDRLVHVPLKSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVX0</accession>
    <name>A0A7D5UVX0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g062180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26244606"/>
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    </dbReference>
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        <property type="entry name" value="BLL1166 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39166:SF1">
        <property type="entry name" value="BLL1166 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06042">
        <property type="entry name" value="NTP_transf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="206" mass="23358" checksum="435EE22124646A21" modified="2021-02-10" version="1">MNPAHLPIHDQLDHFKAAVSTNKTLLTVLSRAPSLHLSNWYLAGGAVSQTIWNYMSGLPPEHGIQDYDLVYHDPSDLSYEAEDAVIQRGKTLFADVPVQVEIRNQARVHLWYGPKYGIPCPEHKSTESAIEQWLTTSAMVGIHALDDGKWHVYAPRGFSDFFNLVVRPHQELGTREAYEKKVSRWKGKWDKLVVIPWAVHHGESGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWZ7</accession>
    <name>A0A7D5UWZ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xecD</name>
        <name evidence="7" type="ORF">G6M90_00g032410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWZ7"/>
    <dbReference type="GeneID" id="26243975"/>
    <dbReference type="KEGG" id="mbrn:26243975"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl phosphate synthase ATP-binding" evidence="6">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="262" mass="27699" checksum="E2EAD3D2107CD5D5" modified="2021-02-10" version="1">MFRLPGVALITGAGGTGIGAAVCKAFARSGCSRFAITDINPTSLQSTRAAILEINPKASVSSQAGDVSDESFVDEFVSKSTGIFTRIDYAVSCAGILGPSLRSHQTPVSEFDKITNVNYRGSWLLSRAVLGQMVKQQPLPEHPEQRGAVVNIASNLGIVARPTAAAYCASKAAIMNMTRSDAIDYSSDNIRVNCVCPGVTATPMTTGSDEIKARVRPAIDIAPMRRMGRPEEIADAVLFLCSKQASFIQGHALVVDGGYTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXA4</accession>
    <name>A0A7D5UXA4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase D 3'-phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g059550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544525.1">
        <property type="nucleotide sequence ID" value="XM_014689039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXA4"/>
    <dbReference type="GeneID" id="26242937"/>
    <dbReference type="KEGG" id="mbrn:26242937"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465:SF1">
        <property type="entry name" value="DNA LIGASE D 3'-PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39465">
        <property type="entry name" value="DNA LIGASE D, 3'-PHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA ligase D 3'-phosphoesterase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="437" mass="48670" checksum="460673FC5391879F" modified="2021-02-10" version="1">MATKQPADLIPNPFIKKRNLQWTLSPPKPPNPSSPPNAPSSPKCNTTTNKPSPPTTAAIESGKAHIANPLAHFTTHLENHVLPCPAPLLPIPSYASLYAGSLTSQSSHFVIHQHDHPIAGLHYDLRLQINPSSSVSWAIMYGPPGDPNSTRLNRNATETRIHSLWNHLIETASPQTGSLLIWDTGTYTVLPRRSKHAPRADPSSQPSPDDEERPQQELLEAAFHNRKIRLQLHGSKLPETYILNMRLTKREDAEGRAKSSRAPRTKRRRVKRADPETSSDSGDVADEDDEDEETTLVPKGRQPDGQEVSRIALEAELQELEDAEIRRTNAYPGASNTIGSIHQRKWYLSLDRKACGFQERLQGGKTVWQLPSTSASSASTPDTRGEKDAMQRLSFPFYVRGVEHERSVVTARTGGDIMRDERVQGFVRRKGWLPVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXB0</accession>
    <name>A0A7D5UXB0_9HYPO</name>
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        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g054860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014685434.1"/>
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    <dbReference type="GeneID" id="26246226"/>
    <dbReference type="KEGG" id="mbrn:26246226"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NmrA-like"/>
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    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
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        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="302" mass="32495" checksum="84FD04BE69CD234C" modified="2021-02-10" version="1">MALRTVAIAGATGNLGSHVARAFLSPECRTRFQDIVVLARAESKAAAELAAAGAKLRVYGEDNLAQSLQGVDVLISVVGPSGHAFKEKLLRSLPATSVSLYFPSEFGVNHYIHDFPHEEWDTKKRHFELAKQLIPNIRRCRVYAGLLLEDSIGPWFGFNTKDGRYEAVGSPSQPTSYISKSDIGRALANLASLPLGDVPDEVSLNGDSKSFQEIADIMRASGAGQIDVTSVPLATYKAQVLADPSPTPERYLRFLMGEGKIDHSDTGLGNQNGVVLSGGPVAWMRMQDLAKETGGKPWASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXR5</accession>
    <name>A0A7D5UXR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g052470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_014684889.1"/>
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="97" mass="10882" checksum="371AE0213CD160BC" modified="2021-02-10" version="1">MTFDGDKTLYLHARCPSQGGLSDFWAFNIETLVWIEIPPAPATARRTTSIAFCQAELYRMGGFHRKTELGGNINIYEPSVKGWTTTSFKVDEMHGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXS8</accession>
    <name>A0A7D5UXS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g060100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544579.2">
        <property type="nucleotide sequence ID" value="XM_014689093.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26242991"/>
    <dbReference type="KEGG" id="mbrn:26242991"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="56"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="228"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="434"/>
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        </location>
    </feature>
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            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="661"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="790"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
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        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
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        </location>
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            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1429"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="2338"/>
        </location>
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        <location>
            <begin position="1812"/>
            <end position="2028"/>
        </location>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
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        <location>
            <begin position="132"/>
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        </location>
    </feature>
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        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="997"/>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
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        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2207"/>
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        </location>
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        <location>
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        </location>
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        <location>
            <begin position="2276"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2328"/>
            <end position="2338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2338" mass="257663" checksum="2B6641A6F9FB29EC" modified="2021-02-10" version="1">METPCGAVHFPKRGGGHNIESGHMSFVDPYFGARVVKQDISGTAVIGRALVKTSPLISSTTPAPGASAQDGTGESRSRHPSPSSPALSTASTADGEEEDIESSPALPPLPAPKLPSRVAQLLRTPPPESGEENSSFGTASWGSPYPRTDHNLRRQSFSSEPSDDSPIHHLNIETPFLRPQPGENPDDQQPQTTISAAAAVLANRARRQHRGLTEDWIRTHTTGVVNAEPRHWFSDGSDSEHSSLSGSQLAWFDDSDPRTPRVIRKPKSASRKSSASHTRRRSSVETLKPKELPQIAAGGVDSSMSDVELQQTLHEVDLTRDVASPIEPRTDVAMVDVFEKSKTSNAQNMNGELETPITPTKSKEKPLPKEPMTTPRIKKKVPWKGKNIMVLVPRDDQRGHAGGAPMPLRPEEVEKMFSSWRELGYSVDGFDLLVEGYQPPGTDDSQSRQDWPTDNDMARERSERIYKVLLPDLNAWKNYVDELQEAKLRALGVSFAEEEPPEPSISPPTTNPSRQASVQYPSLPFSPPIPTSSASSNHGLPSYPFPAQFLPASASPGLPSGASPVSFAPGKFNPRQSISLPTGNSPFQLAQSHGWSNPAGILQGLNRTDSPLASLSGILSPQSPYGLDGLQQSASPGFNLHQRHQSLQYFPQQMGSIASPRLQDVREDEEEDFSKSPSKTPEPTMHNGDNLQAEIEDAEYHLEEQLRNQLEHEDYNPQSMVTKPFAAMHSRDQSSQGLTVAERFANEPGKAMELHHPRPHSRGHSLTQTFFQEQVDEHGLGKLGSLKELPETHKDEDEAQEIETNPSNLGTPVQDFDFAAAFGQHQKTFSTVSNPWQDHESGASSTRRSSHGSKPSLSKLNVQAPEFKFNPASTFTPGAMYNFSGGFQPATFQAGVSTAIPQSLEPTKPVPQFGASKMHASAPSFSPGQGVFSFSTSGPKFRPDAPSFTPFQPLATSPTGGRGHAARQDSIFGNITIPAEDIVRPAKKSKAIPIIRPSSKSSAQSPSAEEDDQLRDGPDGRLADESRVKRAKSAAPDGDMLPAFAEQPEEQEEDIQPGHADEVRDDRSIAEEGSIDGEQTQPGDTSLSSIVTSDQVDTKATTAAPSVTSPAEETTRSLSHSGVDPKVVTPELPSSGLFENKTQDSEDQKFLPATATPFIPVAPPAAQFPSPGSSDKKEDSAQEEPAQEEATAESTPQASRARLTPKPRGLAASRFAKPQSPDVVEQPDVLQSIENEPVTLSMPEPATVPNAFQTRPLVDISEDREPTFEEIDAVMQQMETDPSMGVNKLLESSNWQSQPPNAQICGPVEALQPSIDEFSRDGTSLTPRQFNVIPDATPMLSTELEDPFVDPPISSRSPDSANDPDDAEIASEPASDWEGAFTGDEHDKLENRAQFFDGRVNEVVGTLLASRLEPLEKTLSSIQEALTLQHRRNQSTRREIRSMSAEMQESDADDEDEEPAPQRSISPRRDRRMEHIRLAVTEAFAAQQRNQPIVSAVEREAPVNDDSAILKALEEMKEHFTASLKTASVPDEEKESEARGRELLTPGPDEQAQNKINELQAMMMDLAERLSNEQRKTEKEIAERRAAEDAGAELNRKLQAAETRVEVEIINRSVFDQRVADLEERLRHQEDKTEEEVKTRRAAEDRLAEVQRLLRISSEEEGRLRDLLDEKDARIKSLEQTGGKNAMRMTVLEAAQTNSTKSQTEMTNKFNALDADLKAVRQDNHHWRLEAERADESARRTAGELAHTLNENKHLQKSLHTLTSQLEENERLRESWRSKFLSLQEDMGKAAREVAEENARHIKRDQAMCARQEVLEARLQAEAKTRERLEIEMERLQENERSGMRAVNECKRLEGLLGELRTENHKLQQAASRYQREFEEARESGASEVKRTRMSLQTEIDAANNQVNVIREELEEQNSKLRTELDNVKLEADTAKAQNEMLLEEAQSTKAAELEAAERKYQNEIEDMQARYERQVNNTTEDASRTEQQLLERLSLSSSKIEHLQDRIMHLEDKLEIAKEAAAAAAQAAKTAGTESGAAAVVSRPQQAPKSLELPEKISPQALRESIMVLQEQLQAREQRIEELEQSLSKSDPDAAAKISKRDDEISWLRELLAVRHSDLQDIISALSGDHYDRDTIKDAAIRLRANLQMEEQERERALNGGSAISLPNIAQSIQAATPRVAQTIGPIAAAWGNWRKSSQPSFRTISGVLSSPVSGSNSTPSKSRGGPASQSSLLSGLLTPPASGLRQAPTSDNRPQPTAFSSTGRRYTLQGSSSVDRDRRESNSSRRSEKTPAAPNTPPRHQERVEQPRTPPMMRQSGYDSDAQPGDFDDHDFFEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXZ7</accession>
    <name>A0A7D5UXZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sphingolipid long chain base-responsive protein PIL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PIL1</name>
        <name evidence="4" type="ORF">G6M90_00g058830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544457.1">
        <property type="nucleotide sequence ID" value="XM_014688971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXZ7"/>
    <dbReference type="GeneID" id="26242869"/>
    <dbReference type="KEGG" id="mbrn:26242869"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="346" mass="38563" checksum="20F396EA72D6FFEA" modified="2021-02-10" version="1">MHRTYSMRTTRAPTASQLQSPPPPPSSTKSGRFFGKGNLGHALRRNAGGAFGPDLAKKLAQLVKMEKNVMRSLETVAKERMEVAQQLSIWGEGGDEDVSDVTDKLGVLLYEIGELEDQYVDRYDQYRITMKSIRNIEASVQPSRDRKQKITDQIAQLKYKEPNSPKIVVLEQELVRAEAESLVAEAQLSNITREKVKAAYTYQFDALREHCEKVAIIAGYGKHLLELIDDTPVTPGETRQAYDGYEASRAIIQDCEDALTNWVTANAAISSKLSTRSRTLSQRRRNNIRTRNEGGHDLSAQDAPLNDGGSWVGRHGEESEEEEEEEEVGSDINAEARGRTKEALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY15</accession>
    <name>A0A7D5UY15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g063680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542517.1">
        <property type="nucleotide sequence ID" value="XM_014687031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY15"/>
    <dbReference type="GeneID" id="26244466"/>
    <dbReference type="KEGG" id="mbrn:26244466"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="140" mass="16462" checksum="C641E611F0F11330" modified="2021-02-10" version="1">MAVILDKRGGDVPLTEEVIESLLENSWAGYDLMNVLVQQQGDDNQTTASLVQKQWRSYLRYEQVQPFLKQHPITRRMMMAGARNIYQWKGVVELLIKYRRDEFLAISNDEHENFGDDRGRFQPWRAVDLIRRLDQARAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY81</accession>
    <name>A0A7D5UY81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g070740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539345.1">
        <property type="nucleotide sequence ID" value="XM_014683859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY81"/>
    <dbReference type="GeneID" id="26247851"/>
    <dbReference type="KEGG" id="mbrn:26247851"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43608" checksum="380F89E8E71823E7" modified="2021-02-10" version="1">MLTRRSFRIASLLLASAVFWIFIRFLSEQEIYSIPQTALSLRQQSPLRSPDASPGATDSASPLSDELEATRQRCASHGFKPFIPAGAARRKVYDLFMINSELDFLEIRLDTLYDHVDYFVIVESPLTFQGREKNLTIRDNWSKFARFHPKLIYHQLEFPADFAPRLTWDFEDLQRDSMLTQVFPKLSGQQAPNRGDVIIVADVDEIPRPETITILRSCTFPRRLTLHSRFYYYSFQFLHAGPEWPHPQATFYQGPDETITPTHLRVGDGGSFFHRELFEKGGLKNASWHCSSCFATIEQLLNKMASFSHIWMNDAKFRDRDKIVESVRQGKDLWGRKTDKFVRVDGNADVPGLLGREEGKRFGYMVSRDGDGAGFTDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ15</accession>
    <name>A0A7D5UZ15_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g062340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542642.1">
        <property type="nucleotide sequence ID" value="XM_014687156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ15"/>
    <dbReference type="GeneID" id="26244591"/>
    <dbReference type="KEGG" id="mbrn:26244591"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="389" mass="43295" checksum="38E44083200AAF69" modified="2021-02-10" version="1">MCRFLVYKGSDEILLSKLILDPTHSILKQSFDSRLRLDTRRGQNNADGFGIGFYTDPKLGAAPCLFTSTIPAWNCTNLQRIASKTASRLIFGHVRATTEGSLSEDNCHPFTHASLMWMHNGGLGGWKYIKRKLGDRLADKWYLEVKGGTDSEWAFALFLDTLERLGHNPSSSPENGFGPTVLRKAVEQTIAQINELTDSIPQDVLQSEDVDTRSLLNFAVTDGHSVICTRYISSSKDEAASLYYSSGTQWATRTSDPNDRQYQMERKDKGADIVLVASEPLTFERENWVNVPTNSILTIHRQTVMTHPILDKYYERDPYHVRSSAFVQTKGLVSNEKQPSGTSISIGSGATPSSFDGYRKLAAQTLCSRSISPDLARRALTPLSANESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ52</accession>
    <name>A0A7D5UZ52_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DAC_1</name>
        <name evidence="4" type="ORF">G6M90_00g079290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987030.1">
        <property type="nucleotide sequence ID" value="XM_066131121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ52"/>
    <dbReference type="GeneID" id="90968019"/>
    <dbReference type="KEGG" id="mbrn:90968019"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028966387" evidence="2">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="46"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="549" mass="60931" checksum="866029EA3954F3A5" modified="2021-02-10" version="1">MKPLVLALTLILHAAAGAKRQPTPTRGVPNGQHGGDEVAFANEAFEQFILGQMNEWHVPGLSIAVIEGNKTWAKGFGYATLGSEPVTPSTLFYCGSMTKSVTAAALSILIDEQKNGSNLQWTTPISSILKDDFVLSDAWATDHMTLEDALCHRTGYPRHDFSGPFNSSVDMVRKFRHLPMSQEPRVKWQYSNMMYGTLGYVVERTSATRLADFFRDRLWRPMGMLNTFLHPDDALASGGQLAHAYYYNNDTRQFGELPWNDEGSVAGAGMAISSVLDWSRYLRHMISESGPVSAAGHAALKAPHMVSEQDRRIYSGTEFYGLGWGSNMMQNEAVWYHSGRVSGMLSYMAFVPARKFGFVIMLNTESVAALDSIFSTTLFNYFEVASSNRYDIRQGWYDLLRDLDDGLRNCSARLYPGVGGAALPSGMALGDLVGSYYNDGYGYANVTVRCDDWEAAHGSPSVLSLTSDGCRIVVPRAELFGKNVSFQLQHVAGDKWLAWYFVDDYKTVTRPAGCYRAQVVVGPYGKPDMLGMDMRMEGDDLPLTWFKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZA9</accession>
    <name>A0A7D5UZA9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g072980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545764.1">
        <property type="nucleotide sequence ID" value="XM_014690278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZA9"/>
    <dbReference type="GeneID" id="26241797"/>
    <dbReference type="KEGG" id="mbrn:26241797"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="35817" checksum="9FBCCC9C3E9AB39E" modified="2021-02-10" version="1">MGSEKWIHNRNVGTPDHTPRQPSQPAYKADLTSLFLATVFSPFPPGTTMDQVCLSKENVGRLRDLGFKNVAAVVLLPSVRLEAATVAPCDVSILAQTTIVRAVENFPKVSSNETRLDMLLQIFACLVLQPAIARCSSEGADIDVHDTESIPLDMGQPDSLNSPMNSSDLLLYDSLTQTLALQVLWNRGALDEQYTAIQAEAALASLVVLLHRLNNLRLPTSTLVAVTAYADPGDLWTTETAARLAQRILSLQLSGQGLTNFIIGPVLNQHVRLILSSPTGRDPSVNSRASGSVAALDLAEYENAAAVLNWAIRMTEVCGLCSFDLVAPCTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZY4</accession>
    <name>A0A7D5UZY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g075810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545519.2">
        <property type="nucleotide sequence ID" value="XM_014690033.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZY4"/>
    <dbReference type="GeneID" id="26241552"/>
    <dbReference type="KEGG" id="mbrn:26241552"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="25884" checksum="C5C3CBE0E3206679" modified="2021-02-10" version="1">MALPGGYHLRAGTAADLRTVTGLYLAGFGHDGLLDIMFPGRRRHPDAVAAFLYRHFRRRWWTMGWRLTVVVDETLGVPVGFTWWLRPASQLTFWETWVSPYAWFAPLVRMYLCLEALVLRSPIDPGPVDGFYRAVRAAEPQFLTTPRRREAWYLSTLAVHPVYQGQRLGRALVQEGLELVDKAGSASYLVGLRSVEAFYPRYGFKEVCRVNVGELKAWDGGSVMFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V068</accession>
    <name>A0A7D5V068_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cobalt/magnesium transport protein CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">corA</name>
        <name evidence="10" type="ORF">G6M90_00g055460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544141.1">
        <property type="nucleotide sequence ID" value="XM_014688655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V068"/>
    <dbReference type="GeneID" id="26242553"/>
    <dbReference type="KEGG" id="mbrn:26242553"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="582" mass="65282" checksum="5969F9BF401B0C5E" modified="2021-02-10" version="1">MASEKQPDEQAPSPDPPRPQTSSDLHAAYHPGVDAQNLSPRRAEPRKRSARSDTEIYRDSFLSPVLVRRRSSRTNTFKTVDDCDDFDTYGALPGWQPGSEPGYDPELPDGGHASMPALSAECDITVVDFALERMAKQHFNNESFIAFLDKPKEAWAKCRWINVNGLSWDVIQAVGTNKGLHKLALEDVMNLRNRTKADWYPSHAFIVMTLQKLVHLVEDDDGSSTSSSAPSQTTAKRWLHSLGHKTAKQAERDPEHHARDARGGPVLADGSTLPETCMIRSLQRYHASGNEARTEYMEQHSSLAAYNMAVSAEQVSIFLTNDNTVISFFEVSADDVQRPIVTRLSTPGTSLRESCDASLLVQAIVDAIIDLAFPLTAVYTDLLGDLELDVLTAPSIKQCRRLYICISEINKMLRFLNPIDNLVNVLRDHRTHLTQELASRELENPASGVIVTPMTHTYLGDVLDHCILITEAMGQLKQSSENLINLIFNTISANQSASMQQLTMVTIIFLPLTFITGFFGQNFEGFPELHNGIWYFWACAVPTALATIVILMRDMIYAWFVRLVQRKQIVSLRKRKRRSRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0A1</accession>
    <name>A0A7D5V0A1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">G6M90_00g088680</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542247.1">
        <property type="nucleotide sequence ID" value="XM_014686761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0A1"/>
    <dbReference type="GeneID" id="26244761"/>
    <dbReference type="KEGG" id="mbrn:26244761"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI71514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11510" checksum="32E84244A3F9E703" modified="2021-02-10" version="1">MASGYGMHGGVGRCFPFWQEVMACYVVNTTAEDDHGKKKCSPGLEDYYECLHHKKEHARAVAMKAAYARSEAATPRDDAPSAKQIRNLGLLGKEEDTKKVLHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0G3</accession>
    <name>A0A7D5V0G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">smc5</name>
        <name evidence="13" type="ORF">G6M90_00g092050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541849.1">
        <property type="nucleotide sequence ID" value="XM_014686363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0G3"/>
    <dbReference type="GeneID" id="26245317"/>
    <dbReference type="KEGG" id="mbrn:26245317"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="77"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="358"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="685"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="821"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="911"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1119" mass="128666" checksum="99641F0FBD47202A" modified="2021-02-10" version="1">MPRLTSRRRRRSDTGDAEDSGDVWNGFGSQASDSSKRRRLDSESDSDGDTGPSAPSAGLVNGVSNGDIMQDFQPGAIVRVSVQNFVTYEKAEFFPGPHLNMVIGPNGTGKSSLVCAICLGLGYSPKHLGRAGSVKEFVKHGKDIATIEIELQKKPRDRSNYVIKVQIRREQNSQKWWLNGKETSHKKIQELMKSMKIQVDNLCQFLPQDRVVEFAACTPIDLLHETLRAAAPEEMLLWQSQLQEMHKEKKGLADAVHSDVDALRILENRQQGLQADVDRIREREEIQEKVENLQSALVFANYSEARENHSKARDRKKEAERTLQRLESESGPSLEAVNMKQEYAQQVRAVVPAKERALKDAENAVQSAARDIHGAAELVKEMNNRLEAERKGFESKKKDLAASRSKITAFQADLKNRPTDFNAADWNQKIRAEEHNLREMEGEQRQVSADRDATKERVRPMNVDIRKIKTDIDAFDTQQGQQMSLMRKQFPEASNGWEWIKEHQNEFEKEVFGPPMISCSMKDERYADQVQALLQMDDLLCFTAQTKNDYKKLTDQLYRVMSLSVVVRTCSNPLSAFKAPVDRAQMAELGLDGFAIDYLDGPEPVLAMLCSEKRLHMSGVSLNDHNEQAYDRLINNGKINQWAAGRQSFTIRRRREYGPQAMTTITKNIQKGRFWTSQPVDMQEKREMERRLTELQGEKGALKEEHDRLQQKLDTIEEQKKEISEKITALRNEKSALQKEFQKWQSLPVKIESEERQKAMHEEAMRDARKNMQEIQYEWDKAVLERAKLVIKHKKLTDKIREAHLALIEAKIWLIEANSDVEGLKERNASIMAQLEEERRNVQVATEETNRTKEIGRRLGEDVRELISRDPDRRDLYTQLAEGKSPHEVELEMAAEEAKLELIHAANPNVIREFERRAEEITRLKHKMEGANEKLETLNRQLARVMSKWEPKLEELVSQINDAFAYNFEQISCAGEVRVHKEEDFSQWALDIMVKFRENEALQQLTAHRQSGGERAVSTIFYLMALQSLAQSPFRVVDEINQGMDPRNERMVHERMVEIACREHTSQYFLITPKLLTGLRYDPKMRVLCIASGEYMPKEGRKVDFARCLKIQKRLMAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0M3</accession>
    <name>A0A7D5V0M3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ADP-ribosylation factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARF6</name>
        <name evidence="9" type="ORF">G6M90_00g079900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539534.1">
        <property type="nucleotide sequence ID" value="XM_014684048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0M3"/>
    <dbReference type="GeneID" id="26247698"/>
    <dbReference type="KEGG" id="mbrn:26247698"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20781" checksum="EAB3AE74F3205881" modified="2021-02-10" version="1">MGGQFSKVMGRLFGAKEMRLLMLGLDAAGKTTILYKLKLGQDVTTIPTVGFNVESVTYKNVKFNVWDVGGQDKIRPLWRHYYSGTQGLIFVIDSSDRGRMEEAKQELHRIINDREMKDSLLLVFANKQDLDDAMDPKQITEALELSKIKDKAWYVVPSCATTGEGLLEGLGWLSTNVKSPPAPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Q5</accession>
    <name>A0A7D5V0Q5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g087140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542404.1">
        <property type="nucleotide sequence ID" value="XM_014686918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Q5"/>
    <dbReference type="GeneID" id="26244918"/>
    <dbReference type="KEGG" id="mbrn:26244918"/>
    <dbReference type="OrthoDB" id="46189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="785" mass="87550" checksum="1C47558C681AFA8A" modified="2021-02-10" version="1">MASVPDPATLTSCADIFSGSHTLPQIRSIHKSLHVQIEEKAARLRTQVGGSYRELLGTADTIVQMRGDNSRVQDLLGNMGARCGRTVISSKAAGLGKFVTRDRDPKAIETATLKLLDSCGLMIARILKGGAGVDEHMRKGDRLVLATKVFVIGRLLIKSLKEDVSSEHAQHMVDAAGKTLESLRRRIQRSIERLLENAGDATDTEDVIKVLCAHSLANSSGAKHAIWLFIRVRQRAMETALDLEESERTTTTEDVVRSLRLYTKTLLDVQALVPVKLSQALSALKNHTLLADASLKKLEGLRLDIYERWCSDDIQDFTPFIKHDDLDGKQAREMLGAFAEKGGQIVIAGLQKTLDHMVDFKSITDLRTQVLQLWIRDGGRAKGFDPQDLQDELREAINARLLAVVEIKATKLRLVGSEVKATLEMWQSSISDTHMSLWDDEGYDVALSHGAAPFIQEVVSRLYGRNDAVSRATHSYSSWFHIIDDVKTVVEQLRRQRWDNDYDEIEDEETIEARQKALSKEDPKKLQEKLDTTLDKSFQDLEDQLKGLWKQYSEHTSSGAIAIYLIRVVRDIRTQLPDRPAVKDFGLSMVPSLHNQIAVMASKAATEEFVSSGLLDKSVSMKPLWEGEPALPNQPSPAVFRLLRDLSLSMTDFGVDLWTPVAMAVMKNLLGIKLCKAWHKELSGLSTEGGRSEKDDNGDEERADLNEEENSKGPEADTMAICTQWLFDIALLRCCIAKGEGAQEFERLDGEVYNKSGLDEAARKKIHKTAQDFWGRVNLLFGLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1L3</accession>
    <name>A0A7D5V1L3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541156.2">
        <property type="nucleotide sequence ID" value="XM_014685670.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1L3"/>
    <dbReference type="GeneID" id="26246145"/>
    <dbReference type="KEGG" id="mbrn:26246145"/>
    <dbReference type="OrthoDB" id="4939437at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="176" mass="20883" checksum="50CEE3DA23C06DE3" modified="2021-02-10" version="1">MKLSPEEIQRRLPRHVLTDGHTNSLGLCLLEKVAFAWYKMAERRRNPIREGHYRVYHIDGEGRFQYQDWDPTDWSTCELTNRVSKHMLLLHDSAELRQKRRIPHRYQGVERLFAALTLAYYLVATYRLMLAVSSPGFHLEEILFVLLGFVQIDRVFYNFRATRITSERTQSAARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1U1</accession>
    <name>A0A7D5V1U1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA export protein mlo3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mlo3</name>
        <name evidence="5" type="ORF">G6M90_00g071980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545863.1">
        <property type="nucleotide sequence ID" value="XM_014690377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1U1"/>
    <dbReference type="GeneID" id="26241896"/>
    <dbReference type="KEGG" id="mbrn:26241896"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="25845" checksum="E22656E821E160A7" modified="2021-02-10" version="1">MSSKLDKPLDDIVSAKRQSARNRRSSQRRSTGPKVAAPVGGIQKASKPARGSAAKPAPAKAAAAHGESKVIVSNLPKDVSEQQIKEYFVQAVGPIKRVDLVYGPNSVSRGIANVTFHKPDGAGKAFQKLNGLLVDNRPIKIEIVVGAAQADKVMPAVKSLAERATQPKAQPKSAASGKGATGGVGKAGNAKAANKKRRGRSARPAKKTAEELDSEMTDYFKSNAEGANAGAAGATGAAGATGDAPMEDEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1W5</accession>
    <name>A0A7D5V1W5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mandelamide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdlY</name>
        <name evidence="2" type="ORF">G6M90_00g081340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543373.1">
        <property type="nucleotide sequence ID" value="XM_014687887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1W5"/>
    <dbReference type="GeneID" id="26243550"/>
    <dbReference type="KEGG" id="mbrn:26243550"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005688">
        <property type="entry name" value="PRK07488.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF151">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="491" mass="51370" checksum="620E0A2128B00DBF" modified="2021-02-10" version="1">MSTVTSEAREGDFSGWSADDTILALRHHKVTVREHISEVLGRAERAKSLNAFINLLPDQALAAADKIDAVIAKGEPLPPLAGLAIVVKDNINMAGFPNTGGTNALLTACPSNTAPSLERLTAAGAIVIGKTNLHELAFGVTSTNLSTFAGPVRNPYAMDMIPGGSSGGTAAAIASRVVTCGLGTDTGGSSRIPAALTGIAGYRPSVGDGGEQRRYHDDHGVLPISHTRDTVGPMGRSVADVALLDSIISGRPRAKPAQLRGVRLGIPPVLWAGLNKELEKMVLRAQHVLQDAGIELVRDDIPDLLELDSTVGPPISLHEARTDIPAYLSGSGIDGVRLEDIFDGISSPDVKPIFGSIINGDFGHEYRQVMAVRRPALQKLYADYFRQHRVDAILFPTTILPATPIDIIHGSGNVSINGGPQMEAFAAYTRNTAPASNAGIPGLSIPVGKTADGLPVGIEIDGPLGSDDRLLSLGLAMEKVLGCLPGPEPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2S0</accession>
    <name>A0A7D5V2S0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ech1_1</name>
        <name evidence="9" type="ORF">G6M90_00g092060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541850.2">
        <property type="nucleotide sequence ID" value="XM_014686364.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2S0"/>
    <dbReference type="GeneID" id="26245318"/>
    <dbReference type="KEGG" id="mbrn:26245318"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="30896" checksum="71C57BED377E98E0" modified="2021-02-10" version="1">MGENGYTHFRVTVPEPWVAHVEINRPDKLNALSQEVWLELRSVFDRLSVDPSVRAVVFSGSGEKAFSVGIDLKWVAKEGSPFVPRPEEYADPARRAAALRRFGIEFQDCITSIEKCEKPVICVLHGFALGVTADICSAADIRICSKDTVFCVKEVDLGIASDIGILARLPKVVGSYTWVKEVAMTGRNFGADEAYRVGFVGSVLPTKQDALVEAFRVARSLGGKSPVAVQAVKHFLDYSRGRTVAEGLQYQLAYNTAVVQTKDVPDAIKALMSKKAPTFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2X3</accession>
    <name>A0A7D5V2X3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">itt1</name>
        <name evidence="16" type="ORF">G6M90_00g097070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546632.1">
        <property type="nucleotide sequence ID" value="XM_014691146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2X3"/>
    <dbReference type="GeneID" id="26241055"/>
    <dbReference type="KEGG" id="mbrn:26241055"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23134">
        <property type="entry name" value="RING-HC_ITT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="201"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="205"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="566"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI73375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="689" mass="75476" checksum="C5110E8E8DAE2812" modified="2021-02-10" version="1">MDNAGDDDDPRLMELETLEAIYPEIRHVLSSPGPSQEGEPRFTFELELPVQPAKPVTVLFPAASSGVAQAERPAPASASTPAALAVEPVDSLLVSHLPPLSLKITLPDGYPSDKPPAVTISTTPQWLPDATLRVLEDDGPRLWEEAGRDMIAYTYIDHLHREAENVFGAINTGFTLEVDPDHKLAVLDYDINAKKAAFEKETFECGICLDPKKGSKCHKMMDCGHIFCLQCLQDFYTDAIKEGNLSTVRCLTPNCAKDRAISSSSPSSSSTMAKGKSKTAISPSELLQIGLPEDMVKRYVTLKYKTELEADKDTIYCPRQWCNGAARSKRHKKPEGLEFAESSGDESPDTITEDDAAHEVDEKASTKNKSKAKKFDPADLLSVCEDCGFAFCSRCLQTWHGEFVRCTPKRNKDELTEEEKASLEYLQLHTSPCPTCNAPAQKTHGCNHMICSRCDTHFCYLCSAWLDPANPYKHYNTQPDGKVTSCYMRLWELEAGDGGDVGLGYIGGRELGRVPVGGEDLAEIIPEIEEPESEDDSESDNEETLELNPPVAVAREAPLVLRLMDNQPRREPAPQPPPPPARAARGGRGQANRPQGRGGAHQYVVPAGGPHRRGQPAPRAARGHRHRAGRGNARHQNPQEAGAPNANAGALDPAQEAWVRRFVQMALMDVEDQVEGGDSDSDDGNWQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3G7</accession>
    <name>A0A7D5V3G7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">G6M90_00g100190</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546330.1">
        <property type="nucleotide sequence ID" value="XM_014690844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3G7"/>
    <dbReference type="GeneID" id="26240753"/>
    <dbReference type="KEGG" id="mbrn:26240753"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="707" mass="78483" checksum="13AA6EDF99F1FE65" modified="2021-02-10" version="1">MASADLKHFLADQPPSVVRLEIEQHFEALNDKQKRYAHFISKACFAGTRIVLRQISPESEPIYDLILTLHKSCNGNWDALAKKAGVDDAELTSFLEYAAMFLGNNGNYKSFGDSKFLPRCSDKTVAALAATSPEAAKFYEATNGGIFSHDKSGLLHLGFIDAGHMTTYYPDSPTITKDEIESVSAWMEKKGLLPENNRLRKNADGSFDILIASVVTSVPAEGGDIGKDTQFTVDDGALKGKTIRLIYGDYAKEMKNIAAYIKQAADNADNDTEKRMHINYNKSFESGSLEAYKDAQRNWIKDKGPMVECNIGFVETYRDPAGVRGEWEGFASMVNLERTRAFGELVAAAPTLIPLLPWNKDFEKDKFLSPDFTSLEVMTFAGSGIPAGINIPNYDDIRQTEGFKNVSLGNVLSAKAPNEKIPFIRDEDLEVYQKYRDASFEVQVGLHELTGHGCGKLLQETAPGVFNFDKENPPISPVTQKPITTWYKPGQTWGSVFGSVAASYEECRAELVAMHLSCEFPVLKIFGFGDGSLDMDGEAGDVLYASYLSMARAGLAATELWDPKSQKWGQAHSQARFSILKCFLDAGDDFCKLNYTKDDLSDLTIRLDRSKILTAGRKAVADYLQKLHVYKSTADVEAGTKFYNEMTKVDLEFWGTKIRNVVLDNKQPRKVFVQANTTLDESSGKVSIKHYDPSLVGIIQSWVDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3I7</accession>
    <name>A0A7D5V3I7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KEL3</name>
        <name evidence="3" type="ORF">G6M90_00g103580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987618.1">
        <property type="nucleotide sequence ID" value="XM_066131619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3I7"/>
    <dbReference type="GeneID" id="26240413"/>
    <dbReference type="KEGG" id="mbrn:26240413"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="585"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="685" mass="77866" checksum="24761C8935AC6E49" modified="2021-02-10" version="1">MAKDKKKNSDAKKAKKAEKAAKQASKGEKKAKTKAAKIEGSDAEDVDLDAVLEEYRRQQEQFLKITETVCHGPPRPRAASTLMASPTDANNLLLFGGEYFNGSLAQFYNDLHIYNIHRDEWRCVTSPNAPLPRSGHAWTRASNPNHVYLFGGEFSSPKQGTFHHYSDFWRLEPATREWTKIEVKGKDKSPPARSGHRMTYWKQYIILFGGFQDTSNQTRYLADLWIFDTVNFVWHCPALPQAQLKPDARSSFSLLPCDSGAVLYGGYSRVKATVNLKKKAGKSQSQGQKNVLIPKVHDDCFFLRMALPPADANSNTLPTMRWERRKKPANPPNPSRAGATMTFHKGRGILFGGVHDVEASEEGMDSEFFNQLFAWNIERNRFMPLGFRKPRQQKRAAPEQPRVGRRGRAQANEEELLKQLAALETGASLDDVDGIEIDKKEEEPEEDEKPAREMPVTMEPPHVRFNAQMAVQDDVLYIYGGTFEKGDREFTFDDLYAIDLSKLDGCKEVFSRPVEDWIESEDEEDDDDDEDDEEDEEDEDEDEDDEPEQLHTLSKRKKQDVVSDTASETTSAPPEEDDTETTATSVDDGLPHPRPFESRREFFVRTTAEWQEILMTSLRWKNIQPETLTIKEIKAKAFELSEEKWWDCREEITALEEEQEAAGIQEVVSLAERGDTGGAGGARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3P4</accession>
    <name>A0A7D5V3P4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g110230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987793.1">
        <property type="nucleotide sequence ID" value="XM_066131807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3P4"/>
    <dbReference type="GeneID" id="90968251"/>
    <dbReference type="KEGG" id="mbrn:90968251"/>
    <dbReference type="OrthoDB" id="4338954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="105" mass="12080" checksum="3593CC35745F0DC6" modified="2021-02-10" version="1">MIYTTALYNRVFSTSARVHPSILPHLRQSRRPPFRWLKAALVLCGAGYIANVYIGRVRERRIADIVAAETKAAELERRNNALLDVYGDRSSLEELEKAVQFYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3T1</accession>
    <name>A0A7D5V3T1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g106510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539867.1">
        <property type="nucleotide sequence ID" value="XM_014684381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3T1"/>
    <dbReference type="GeneID" id="26247306"/>
    <dbReference type="KEGG" id="mbrn:26247306"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="452" mass="50915" checksum="E0744F07C25DCB36" modified="2021-02-10" version="1">MAVPPLKHWPSELLLSLLELLSLNDLLSMSRVNKSIRALALPLVYSTVEVSWTWRRTPPVILLLQSLLDRRELSGYIRNLRLVGNGFKDRPEVREPPVPPLDAHLLSKATEVIESTRVPFTKLWIDELHSGSVDAIVALLLAMVPNLTSLRLGPNFTVRSRLWGGIFQCALCGPPNTYNLPAYEDLRSVKSEFRTKEWHHIDVCNAADVLALFYLPRIQNLSVSIDSPVEFAWPCSHPPAASSIVSLDIYRLRESRIGPVLSVLKGLQRLHWHWSYQPDLDEEVSKDVLDLDTAAVALNEVADTLTDLTIGAITRPRISVGDYDPPLLEFQGSLDGMSRLGKLRKLRLPWVFLMGFSESPASKLLSALPLGLEELELTADLNDHEEWEWDDDDSIIHAVKLELASPSLSRYTCLRRIVLPISSEYCEMTNEQREELSIIGARAGLELGWMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V487</accession>
    <name>A0A7D5V487_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LYPA1</name>
        <name evidence="3" type="ORF">G6M90_00g107280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544112.1">
        <property type="nucleotide sequence ID" value="XM_014688626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V487"/>
    <dbReference type="GeneID" id="26243499"/>
    <dbReference type="KEGG" id="mbrn:26243499"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="293" mass="32532" checksum="EE31AA039B30500B" modified="2021-02-10" version="1">MAGLTVRERLYVVEPRGPHSHTLILLHGLGSNGEKFGTELLDTALTSSGHKLTDLLPGARFVFPTSKRRRSTAFGRSMLTQWFDIARLTDPLYRKERQLDGLAESAREILDIMATELQKVQPQNLIIGGLSQGCAMSLAILLSLEHPIGGYIGMSGFLTYQDELEDAVQDDIDSDDPFTRPSESQDVAVQASPVKAQVLERDLLSLPALECPSQEKTACRTPVFLGHGMADEKVPWVLGEAAAQLVRNAGYQVEWKCYQDQGHWYKIPDEIDDICNFIVSRVGWEVARPIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4S5</accession>
    <name>A0A7D5V4S5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g098800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546467.1">
        <property type="nucleotide sequence ID" value="XM_014690981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4S5"/>
    <dbReference type="GeneID" id="26240890"/>
    <dbReference type="KEGG" id="mbrn:26240890"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47165" checksum="0C7E48E7A4818C00" modified="2021-02-10" version="1">MFALQELGTTLEHARARYIQQNPKSKALHAEASNSLPGGNTRAVLHADPFPLYIKSGHGYQVTSEDGTTYTDFTGEFTAALYGHSSPVIRKTITTVLTTIGLNLSGTTRAEQSLASAICARFNVSKVRFTNSGTEANLQALAAARRFTKKRKVVVFGGAYHGGVLGFAGGKPAANNVDLDDWIVAKYNDVDGATRAIQDEGVAAVLLEAMQGAGGCIVATEEFLKAIEDAARKAGVVFIMDEVMTSRLCAHGLASIRGVTPDLKTFGKWLGGGITFGAFGGREDMMAAYDPSQPDCLPHSGTFNNNTLAMHAGHAGLTEIYTPSVANEFTALGTEFLGRLNEASRDSILCFTGLGTVMTAHFPVNGEKDIRDGDDVEERSELRELFWLEMLENGFWVARRGFIALILGTPRRELDRFVDAVEAFIRRHEAFLKTTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5T6</accession>
    <name>A0A7D5V5T6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcaC</name>
        <name evidence="2" type="ORF">G6M90_00g113250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539778.1">
        <property type="nucleotide sequence ID" value="XM_014684292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5T6"/>
    <dbReference type="GeneID" id="26247443"/>
    <dbReference type="KEGG" id="mbrn:26247443"/>
    <dbReference type="OrthoDB" id="104509at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052512">
        <property type="entry name" value="4CMD/NDH-1_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33570:SF2">
        <property type="entry name" value="CARBOXYMUCONOLACTONE DECARBOXYLASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="46"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="143" mass="16069" checksum="778D78B6F8CE1567" modified="2021-02-10" version="1">MSSDATNDELHRRLFDEGIKVRKDVLGSEYVENALSSATPFTRPGQELITEWAWGTVWQRPGLDRKQRSLLTLGLIIGQKAWLELGLHTRGAINNGMTELEIREAVLHAAVYCGTPSCIEAMIVTQKTINDMVDKGEYKRPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V661</accession>
    <name>A0A7D5V661_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA binding domain with preference for A/T rich regions-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g109590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987989.1">
        <property type="nucleotide sequence ID" value="XM_066131785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V661"/>
    <dbReference type="GeneID" id="26243284"/>
    <dbReference type="KEGG" id="mbrn:26243284"/>
    <dbReference type="OrthoDB" id="5243398at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="74081" checksum="B4EF474DEDC9F753" modified="2021-02-10" version="1">MSPVAAANNLSTDGTSAHRGHEAQPVDIVVGANGGSSIILPSDTLTAAEPLNDDIPYTSGSYAYYDGRVKNGVPAKLQNVDHGKNGNFAVMHMGVTNLASAERLAAARRTSEGTAAASRLFNQAGYKSLRQLKQNGPAVESQQQELVPNTARKERTRGKPQPGHGFAQRTTSLSSHETKTEQARLLTLLRSLNPVMVVDQLCRGLAYFGGIPGAPPPADDSAFPQSNAANGSGHYFVGWLAEIFPNVDASTAPHPSVPDTSPPGNHPATTASPWMSASSPASKSATTVSVAPTVQTDSSPTKEDAIVPGKRKRGRPKGSKSSKVRADKGKRHMSKALKYSVPLVIPAVAENESVAEGDNMEADVPVTSDDAATPVLPDDPNTQSNAPKSTPVAKKRGRPKGSKNRPKTNINDENQTAPRTHDATPAQTQTTATPPSGTANAENIISNNDYSAQSQFAGDNLGRHHAESSPNQPNMSTQQPIAASTSSSSPRKRYVTQQSQLDVLGSNNQVAPSSQAPQGTKRQRVSNGSVPNIGSGSQPGFLSGNFDSQTQSNGSGVEGMGLGPHATQTSRLGQFYIATSPQQQQLESPNLSHAIPRQQTNHPFASQRINAAAQNYHYNQHGLQQTSHHMTPISPSGRSFGPTIANNADVRLSQDQAKQQPAGPQAGGRKQGYFSNHNRPPGTQSSANTALGAYSTFNTQGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6H5</accession>
    <name>A0A7D5V6H5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BCS1</name>
        <name evidence="14" type="ORF">G6M90_00g110300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543829.1">
        <property type="nucleotide sequence ID" value="XM_014688343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6H5"/>
    <dbReference type="GeneID" id="26243216"/>
    <dbReference type="KEGG" id="mbrn:26243216"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="13">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="241"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI74299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50535" checksum="55FEA057D1AFDB25" modified="2021-02-10" version="1">MATPQTSASLFSPDVLFDNPVFAGGIGLASIGAAAAFARRGAIVAFGAARRRLLVNVEISKQDPAYPWILAWLSQPREAAGFIASRITRIHNLSVTTTTTHTKGPYAGGPVNASFFLQPGYGRHVVKFGNAYIAVSREKHSTANMNTGEPHEIVQLTTLWAYRHTFEGIFAEAHRLAAKANEGKTVVYSARGMEWAPLGDPRKKRPLGSVILDDGVKESIVADVKDFLSRQGWYVDRGIPYRRGYLLYGPPGSGKSSFIQALAGELDFGVATINLSEMGMTDDKLAYLLTKLPKRCLLLLEDADAAFVNRRQRDADGYSGASVTFSGLLNALDGVAAGEERIAFLTTNHIERLDPALIRPGRVDMMLRIGEATKYQAGQMWDRFYGDEDNSGSRKEHFLRRLDELGLFGTSPDGTPSNRRTSTAAIQGLFLFNKSNMQGAIDMAQGLIPRKFEDDAASDTAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLD3</accession>
    <name>A0A7D5YLD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar pre-ribosomal-associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">URB2</name>
        <name evidence="2" type="ORF">G6M90_00g018340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548705.1">
        <property type="nucleotide sequence ID" value="XM_014693219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238149"/>
    <dbReference type="KEGG" id="mbrn:26238149"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1354" mass="151857" checksum="EE2B02D9067663E5" modified="2021-02-10" version="1">MDNTDLIKTVRGLDQNGPGDDGQNLQQLWNFLAAAADNQFHAAEESSLRWLLKSMNGTSEAAETLRRYPLTWTILDRVFQRIPLFSLAKSLADRKFMAVLQQTLKDVSKPVGSTEQTTPTKRKRSTLIAYSVDALRSINGCLETAQTLFIAVKSLLNRLDNTLETFSRDKIGAEHIRSLFCTSAVDATAIAAPAFKICENLLSSDSHDQIKGCEDWIQTISSVWDLHLQGTDDVVNVAIYLFRPASVILANVGPFSSANRAQVRDSLKEKWSSDMQAFMHRNFALPGRGAFINHRTLEAFTTALEICKGIIHLAAPALYFIASSTYKDVADSGLRKDNVAWIKETFQAVELAIARRQDRHILMESILEQALGNSAPVGVDDLRRVCRDYALQDDGTRWSLVSKIAQCETDVFQISDDSIELRKEICDRIIKEDNDESNKKAIVEVIGAIQDGFRTHRDLPSFLRLWFQQLSDTERQNFRADSAWITFIRERSQKDSLTSIIETGMSPQRLNEVVAWVKENSSKQNPQATVLFASTVVQSLHSEQYVDAIGRQLFDLVEGLKASTPLTALRWRVVSMTVWCVAPDERQGIWGAVKKRLTKALEKSPILSAEAYEAFRCCYEIWDSVSPDGPWVEEPAGLTEAFTKRLAVEMSSACVLKGTLFSTALGLASEAVFNEDYGYEQYIAWLLNGSSRFNKLYMSKAGELPPALGEVIASRKLSTDGLAILWAALIRNETNLNETKLSHGLVDRLLAAFDESGKEKNWPGEKGQMWMRALSSIPLDCFDRDQREKLTTILAKRQSMLTEPATKDDVNSWKLLLSLICKIMKRPTFHEGMRFSDLVEASQTLSHLSMTSEDSIETILEVIERFSHMASLVIKQMAGHVDERSAKYFREATTFVSICEKQADGSSDHKLDLPALHMTLLKSLGTELTQSVNARSNTDFAPLLTTTRKALSKCITKVIKFCVSEKKVLELSSLPVDMSIMAAVDAAAATEFSDKNDLKSSSIRKLEKRTKQAMQDGDLRAWKIQTFLRAYLSDKLEVSHPTTFDDLKNLPHRMREVVLRELVQSVSANMDGLSKLAYLRELLRELKGGCNTDGQLLAIEYLANQIIESSDFQLQTDDGFNIGMVHSDLTSLLLRKPSNSNIICRILRALLEKRPQLMSQWNIEITLSTVSDLASDRHAGESTTSYPWLCKLVEVIIKKHRLRLEGHFHLLLSTLQALLQNLIKSQQHSTATDNLAQEAKAQLYARLVTLICEPTVGAVSRSQLHSSLDSATDAAKRSAGRHMYLILVHYVKLQLETSVSTEVRDALEQAMNSIFDITPPEGRKILNDTMDSSGRAILREMFKRYVKFGKWSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN38</accession>
    <name>A0A7D5YN38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase (Ubiquinone)-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g004930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542139.1">
        <property type="nucleotide sequence ID" value="XM_014686653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN38"/>
    <dbReference type="GeneID" id="26245170"/>
    <dbReference type="KEGG" id="mbrn:26245170"/>
    <dbReference type="OrthoDB" id="5417628at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="62158" checksum="743CBC32B578C11B" modified="2021-02-10" version="1">MRYEDWDILLFPQNCKVPVKEFKVACHVVHDPESPHLGGTFGLPTVCCFVPSLPTGTPFRVSIHSWNAPVVSKFTNSYSKFPENVKFEARLFIDGRLVASTALDRESLWPHIVAHSFDFSKSGDLEPLSFPGFREELLQQNFWSPADDLGRIKLVLSEGFPRDSITTPFERVKNVVAFSFQHAPLEVLESSSIAWPNPSMWRRAPFAASMQVPTLQPDDSESHAHSPQRRGSSSDKLSYATNSFQSTGTNSVLMPGGRRVTHPVYGPCFYPTQNGLDPFGNAGSYFEWLNCMDIGMTAAAGDNHFNPNHSSVAQRSTRRTSTDVSMPDYVPAKSDSQCVEQQLAPEPFPGEDGRQSEQSKAPINAPSADVEHKREGAAFPVPTDNTSFPPELADSLTNSLLNQPLPMNLHHSAFHTPAAEVISRKEHRNQQHSGPSPTTAMDGSVDTQERLETRHVSQQLYTPQGPSIAIGKVGMAENSLNHSDYCASAMTRGNALQACCPGHKPSSEVQDEEAKHGGGKGAKRMRNFISVSSRAIDEEDETRRLSPRVRLTSFLEGQASADTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YND4</accession>
    <name>A0A7D5YND4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rhlG_0</name>
        <name evidence="8" type="ORF">G6M90_00g004090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542062.1">
        <property type="nucleotide sequence ID" value="XM_014686576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YND4"/>
    <dbReference type="GeneID" id="26245093"/>
    <dbReference type="KEGG" id="mbrn:26245093"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="291" mass="30770" checksum="62C3F57A99DE4BA7" modified="2021-02-10" version="1">MASTDALTSNSLFKLQGRVALVTGGGSGIGLMAAQALAANGAKVYITGRTKEKLDTAKSQHFGDDNSNVITIQADVSSKESIQSLVKEIESREKCLCVLVNNAGIAADHHQTAEAKSASELRDSLFQQSDFDNWTDVYRTNVAAVYFTTAAFLPLLQASSERHAGWSGTVINITSISGLVKTSQHHFSYNASKAAANHVTRMLAAEIGAAGLKIRVNGIAPGVFPSEMTAGESDEAQKSQLPKDKYQGKIPAARPGKDEDMASTVLFMAANQYVNGHIVVVDGGYTLSAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPD9</accession>
    <name>A0A7D5YPD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g034510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986361.1">
        <property type="nucleotide sequence ID" value="XM_066130152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPD9"/>
    <dbReference type="GeneID" id="90967610"/>
    <dbReference type="KEGG" id="mbrn:90967610"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7424" checksum="0F17FAB6B7A40193" modified="2021-02-10" version="1">MSRGDVSEKYAYKHQCQRYIEVIRIGEKDGGIREIEPGQRMMSTSASSDLLALHVSEKLTRRAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQP3</accession>
    <name>A0A7D5YQP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Manganese-transporting ATPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SPF1</name>
        <name evidence="18" type="ORF">G6M90_00g010560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549463.1">
        <property type="nucleotide sequence ID" value="XM_014693977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238907"/>
    <dbReference type="KEGG" id="mbrn:26238907"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1104"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1186"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="259"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1266"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI65962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1314" mass="146976" checksum="06BE2A1889D5704D" modified="2021-02-10" version="1">MPPLIDSPQIKQAELLRPLSFHFHTYVWPFAIIWPIFLRYYLTPDLYEEYIGAPEWTFVWCGTIITLQSLVWLSTHWSVSLEARFKATRVDTVEDAQLIKVLPIANAGSGEICKLVRDKVGGKLITSFLFQKRRFLYNTETKSFSTLQYDIDSEPKPTIGHFQSFRGLEKQSELTRVEQHYGTNTFDIPVPTFTELFKEHAVAPFFVFQIFCVGLWLLDEYWYYSLFTLFMLVAFESTVVWQRQRTLNEFRGMSIKPYDIWVFRLGKWIEIQTDALLPGDLVSVDRTKEDSGVACDMLLVEGTAIVNEAMLSGESTPLLKDSIQLRPSDAVLDPEGLDKNAFLWGGTKVLQVTHGNPEQEKPKLSSHVPTPPNNGAMAIITKTGFETSQGSLVRTMIYSTERVSANNFEALLFILFLLIFAIAASWYVWDEGVRKDRKRSKLLLDCILIVTSVVPPELPMELSLAVNTSLAALSKLAIFCTEPFRIPYGGRIDVACFDKTGTLTGEDLVVEGIAGLGLADSNIVDTKEADGAHSTMVRVTEASVETQLVLATAHALVKLDEGDIVGDPMEKATLTSLDWGLGRNDILASKNKYSGAQGTVQIKRRFQFSSALKRQSSVAMVNGISRTGKKVKGTFVGVKGAPETIMKMLVNVPADYEETYKYFTRKGSRVLALAYKQLTVDSELGSSKINDLKREKVEADLTFAGFLVLHCPLKEDAKEAVQMLNESSHRVVMITGDNPLTAVHVAREVEIVDRDVLILDAPEDNVDGKKLVWKSVDDKISIPVDATKPIDAEILKTKDLCVTGYALAQFKDEAGWNSLLRHTWVYARVSPKQKEDILLGLKDMGYYTLMAGDGTNDVGALKQAHIGVALLNGTKEDLTRIAEHSRNTKMKEVYQKQCDLMKRFNQPAPPVPVMIAHLYPPGPSNPNYMKAAEREAKNKNMPIEDYIRAQGHPTETIVSPGAQSLANAQDARQAEVQKKAAGFADKLASGMLEAEIGDDEPPTLKLGDASVAAPFTSKLRDVIAIPNIIRQGRCTLVATIQMYKILALNCLISAYSLSVLYLEGIKFGDTQYTISGMLMSVCFLSISRAKVVEGLSKERPQPNIFNIYIIGSILGQFAIHIVTLIYVARLCEKIEPRSGIVDLEAEFEPSLLNSAIYLLQLIQQVSTFAINYQGRPFRESLSENKAMFYGILGVSGLAFVCALELMPEINEQMKLVKFTEEFKIKMAVVMALDYVVCFVIEKGLKAGFSDYHARDIAERRPEQLERENARKKIEAEKKAADEEAKRMEKVAEFERQVAERRRKLEEWRAGRRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS11</accession>
    <name>A0A7D5YS11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mug134</name>
        <name evidence="4" type="ORF">G6M90_00g011230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549397.1">
        <property type="nucleotide sequence ID" value="XM_014693911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS11"/>
    <dbReference type="GeneID" id="26238841"/>
    <dbReference type="KEGG" id="mbrn:26238841"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="154" mass="16571" checksum="594B7932D3BD8E6F" modified="2021-02-10" version="1">MNPHQKNKVDVKSLSPEEQRLFRLYGKLPSRSDHFAKHLKDRKYFDSGDYAMSKAGKGDGVDAGAVGSQHPVPENIPHLSSPINNGASIPKHGHHGSIAGIQAGSPVKESSFLHRETSAEDASTGDDSIPSNNKENVSLTSAPLQSNEGIPIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSQ3</accession>
    <name>A0A7D5YSQ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g034030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543330.1">
        <property type="nucleotide sequence ID" value="XM_014687844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSQ3"/>
    <dbReference type="GeneID" id="26244131"/>
    <dbReference type="KEGG" id="mbrn:26244131"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560">
        <property type="entry name" value="BLL0132 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35560:SF3">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029007229" description="Transmembrane protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44926" checksum="2FF97EEF67E028A6" modified="2021-02-10" version="1">MARLSDTARVAVAIIVTLLGVCRAATTFNFCDEASAKEYAYNPPPERLIAPRRNCNRGKHSSPQRCIYRPPGSRLASIHVGSTGKLAVFMPNKMDAATVEHAVIIVAGKLSNAGQYWHRLQNVTALHAARPDKTHRKTISVAPLLFSDRYTPGLHGDRHLSWSGPRAWIAGGAANSPPGSNATSIDALEALADEFACSGKYPLLTNVTFVGQSAGGQLVQRYAALARDRPSCRAHVRYVQNNPATCSYFTADRPSSVQGKALPPARSCAESNLWPFGFDDFPGTAAGTLAPVDYFRQYTSRDVVATVGYRDTNPCSGDQACQAVLQGGHKRRDRNLIWYRYVHELARTGEDLTGFPGTFGDLPDWGPASENRVGLRLALAKDAGHEFAQIFSTPVGQSALFDDLDVLEGWRPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTP5</accession>
    <name>A0A7D5YTP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027730</name>
        <name evidence="2" type="ORF">G6M90_00g027770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539794.2">
        <property type="nucleotide sequence ID" value="XM_014684308.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541379.1">
        <property type="nucleotide sequence ID" value="XM_014685893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTP5"/>
    <dbReference type="GeneID" id="26246014"/>
    <dbReference type="GeneID" id="26247459"/>
    <dbReference type="KEGG" id="mbrn:26246014"/>
    <dbReference type="KEGG" id="mbrn:26247459"/>
    <dbReference type="OrthoDB" id="5104857at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="231" mass="24402" checksum="D20B565EF5B19CAD" modified="2021-02-10" version="1">MSFGDSSFLPLRFNFSTTPCEGQLIAKFTTPAEVPNGEADIFWQCAGLAPYCYQANITNGTSDPTMQLDREAQVGCINEVLRTTSVLVVKTMSTRTTTETAVSVFTWTTTSFPRSQETSPTVTLPSQSWVTSGVATPSSTVMNKDPTGTDTTAARAPAADSVRVEIPRSDMIGRTVRTTSPLPVTTDTVFDSGASKVTTPLVTSAVTTFLTTTLLRTVTVSCAAGSATGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTY2</accession>
    <name>A0A7D5YTY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidomain esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cesA_0</name>
        <name evidence="2" type="ORF">G6M90_00g083830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543600.1">
        <property type="nucleotide sequence ID" value="XM_014688114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTY2"/>
    <dbReference type="GeneID" id="26243777"/>
    <dbReference type="KEGG" id="mbrn:26243777"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="200" mass="21958" checksum="C16D1726048514E1" modified="2021-02-10" version="1">MPLGGSITYGSKSSDGNGYRMPLCKLLAADGHAVEMLGSRRAGTMAQNRHEGWRGFRIDQLQAKVVQSVSGFSPDVITFNAGSNDCRQQYEIDTAGRRVRHLLEGLWAASPRTTIVLSTLVRSADEKAEEAVSRVNEQIWGISEELVAAGRKLVMVDMHVEALGLEHLADGTHPNDEGYAEMARIWYDGIKEAELKGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTY4</accession>
    <name>A0A7D5YTY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Endocytosis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">end-3</name>
        <name evidence="22" type="ORF">G6M90_00g023020</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548253.1">
        <property type="nucleotide sequence ID" value="XM_014692767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTY4"/>
    <dbReference type="GeneID" id="26237697"/>
    <dbReference type="KEGG" id="mbrn:26237697"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF74">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="290"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QLI63765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="397" mass="45205" checksum="3573D98B8E53912A" modified="2021-02-10" version="1">MAPPKIEAKEIETYWNIFSDRTGGGQFLTGEQAAPVLKNSGLRDDQLERVWDLADVDNDGNLDFEEFCVAMRLIFDILNGEYADVPKTLPDWLVPESKAHLVQATRAIAGKQPQFEQVEDDSDDLGLKDGFEWYMKPGDKAKYEHIYQENRDMRGEVSFNALEELYESLDVPDTDVRSAWNLVNPSAGSTINKDACLAFLHILNYRHEGFRIPRSVPASLRSSFERNQIDYQLDSQRAGTNSRWATKADDSTSTGRKTKFGEQYLTRLGRSGFKTAGTDFSTEKTEDWEEVRLKRQLADLETKIQKVEDMADQRKGGKRDSKPALVRRELDQLLDYKRRELRELEEGRGKSAVGSGLKSVSEDLQTVREQVEGLETHLSSRQAVLDDLRRQIDAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU65</accession>
    <name>A0A7D5YU65_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mrp7</name>
        <name evidence="8" type="ORF">G6M90_00g064160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540126.2">
        <property type="nucleotide sequence ID" value="XM_014684640.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU65"/>
    <dbReference type="GeneID" id="26247162"/>
    <dbReference type="KEGG" id="mbrn:26247162"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="268" mass="30600" checksum="B10EF5B37ADA0B7C" modified="2021-02-10" version="1">MQRPLLAVAANCVGVARPTVTGLASLGSAQWANVLAWGRRHASVKAQGAYKKKSKRGIPKKLGAKRTGDQYVIPGNIIYKQRGTHWWPGENCIMGRDHTIHAMATGYVKYYRNPSLHPDRKYIGVVFDKADTLPHPQHAERKRRLNMTAFPIRAAAEKPALSPSGIPFEVTRVEAGEPDRILKLRSDYSYREDNWRIGRLAKTTGLRTKRFRTRKQWFRHRRWRRERELEGQRKAEKNRAESGETKSVKAVSKKAAKKEAKKAAKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV52</accession>
    <name>A0A7D5YV52_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Major facilitator superfamily multidrug transporter mdrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mdrA_3</name>
        <name evidence="12" type="ORF">G6M90_00g078060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545299.1">
        <property type="nucleotide sequence ID" value="XM_014689813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV52"/>
    <dbReference type="GeneID" id="26241332"/>
    <dbReference type="KEGG" id="mbrn:26241332"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="489"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="518" mass="56489" checksum="9B5625219D247A7F" modified="2021-02-10" version="1">MEAVRQSVQSTDSHNTLPVPHTNSHGFVDFGPGDPGDPRNWSKSRKWYITLCTSLLAMVGNLASSIPSGSLKHISRDFHISEGVAALTVTLFLLGYCLGPFIFAPLSEFYGRRPIFRISFSFFVLFSILCAFATNFGTLLTARFLAGACVSAVLSNAPGVLADLWDNLARGNAMAIFSTSVWIGPSLGPIISGFLVLHKNWRWGFYVVLCLAGVSMLFMLTIPETNGAIILLERARRIRKAGIRGYEHVQTEYEAANMSLFTIYKTALTRPWALLLDPISFLCAVYMALVFALQFMLFTIYPIVFQQMRGWNEGVGQLPLLGTVVGSVVGAVIIFLDTKRRKNKLEAGYTLEPEDRLIMGMVGGIGFAITMFWFSWTAQYNSIHWSVPTIAGGFLSTALILTFTSYMNYLVDSYVDCAASAIAVNTFARSLSSAFAPLFTPKMFQTLGVGGGGSLIGGAASVLAVVPFVFHRYGKAIRGRSKYSPLDAAVKLDPEEQDGNPVGNSLRDVEEGSETPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVJ7</accession>
    <name>A0A7D5YVJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Telomeric DNA-binding factor trf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trf1</name>
        <name evidence="6" type="ORF">G6M90_00g034130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543340.1">
        <property type="nucleotide sequence ID" value="XM_014687854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVJ7"/>
    <dbReference type="GeneID" id="26244141"/>
    <dbReference type="KEGG" id="mbrn:26244141"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="574"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="715"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="785"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="883"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="948" mass="101644" checksum="7E78ACF3498487A8" modified="2021-02-10" version="1">MAESALAEASAFSMATGIKQEHEPTGLEGLDFALPPELSSKRPFEEDIGATTETPEAKRAKTETETEEASLEDGLALLVQNALSNVGDLVDQFTSGHETAPEQPASDPMEVDTTIPLPEPPAVRATFVSDPRKFIRDTNVHALGNLALSLLLVLVQSPFEDTIKLVRGSDSQHEKTFRGLKCSFEHVHEMYSPGPVLSANELEFRDPDSQHFIELANLAQLGLRLVDGTPKALSEADENFLAMFQCQLSELPPGMTELYLGIKTQRAIEFLVEKEPEKPSEEVIGEVLTHGLEHTLKEQHGGGELTSADQNFVSSVQTRKETLQGEVKEESEPAALREKHPAEDLLRSFLEYTAGRLKSLTDIGNKLGITIEISDSEPPPEPIPDATGDADMDLDDLSSFFEKTASGLVQNALAGLKDEPTTTDPAEGGEEAAAQTASTENKSEAASAQTNGKIDLMTDYKELEALVAESTSNYVKTTLHGLSPIPYQPTVPTSTTDSMAAQPPYQAQVQHHQVQPPYYTYTQPPPEPQLPPLPGENLPPNQTFPSSILYDKARQAALSKSSAHTRREGLHSTRRPWTQEEEKALMAGLDMVKGPHWSQILTLFGQNGTISDILKDRTQVQLKDKARNLKLFFLKTNSEMPYYLQAVTGELKTRAPTQAARKEAEERARLNSEEDQAKLQGIMALAGGLQHPPQGRTPASPVNAVGSGVVTPAQAAQAASSAQHHAGHQANAAGQGAQATSVPRPTATPASQTRPGGQANTQPSSHSVAQANGRSQAQLPPQVPRPQGQPQHHQQGHQPQPQQTQPAEQAEQAQQAQQPTRTPAMPQPTPNTQAQAQPQPAAAQQHHAATTQPATTSIPTSTPLAAAPPQPITSPARAHSPQVSPPAAQPVPQTQPAPTPSPAPQQHPGPPPEAPKPDSPTQQEQDDNAAEAALLEGLQAVVAQSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWZ6</accession>
    <name>A0A7D5YWZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox and C2H2 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g090740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541732.1">
        <property type="nucleotide sequence ID" value="XM_014686246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWZ6"/>
    <dbReference type="GeneID" id="26245595"/>
    <dbReference type="KEGG" id="mbrn:26245595"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62309" checksum="68E973426BC2F194" modified="2021-02-10" version="1">MSTDNDFFVGVVDATTLEGANDDRRVSSISTSADLESPQSIIGTSAAAGATTVLPAELDWSESLLFGADMGSQDAISPQFSSAIPGFEPQDTSLAFPHPTREYDSAAFSLSLPIQEPAPGLEPALYQEAMEEFFAKNGAWRPPEPCNHCKRLRLQCFMLQTTDANPNPVNSCSSCVALFRNCSLAERSKRGHSLFETSRPVIGHLHGVNEEENQLAWDQISHPGAGPSSGLSGPSPTAGARLTVTSKRSSSRSVRKTQILRDWFAVNIQHPYPTDDEKMTLAEQSGLSRTQVINWFTNARRRHRLSTQPMVNNATFRAGSPMPRSLMTSSMTPFERWKHSPPDSEPVSEAAIQKAIGSNSNIHHEIGAPGDDDDLGSSASTDSMLYSQSALHYSSDGSLSNYSRASVNSDVVLSGRSLEERGHPAWVKSASARSKRSKARTFTCSYCSRNFNKKYDWLRHERSVHAPGDTSWVCAIPLPPEQPYVIWRLGQTQAECIFCGQSSPTEEHFQSHEFESCAKRAVQDRSFTRKDHMWQHLYKFHGCRKWEGWKPDVDLLRHKAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX32</accession>
    <name>A0A7D5YX32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lkh1</name>
        <name evidence="14" type="ORF">G6M90_00g086880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542429.1">
        <property type="nucleotide sequence ID" value="XM_014686943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX32"/>
    <dbReference type="GeneID" id="26244943"/>
    <dbReference type="KEGG" id="mbrn:26244943"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="357"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="733" mass="82133" checksum="6028753FF517738E" modified="2021-02-10" version="1">MSTPTTAVATLPHYHLAHQAHHHPSSTTSNYRTTAANSLLYAPNPSVPTSSSSNAARLLPFDQAGSRNAGYTSSDAITQNLQPQSPPAPPPHDHYLPRDHHIETSTPTTPRHRIHHNYSSTMGSAAATATAPSTAAAAGPTAHDHDPTSRKRRRSREPDWNTFYRNGLPKEIIVIDDTPEPEANSSRKLASSNTNGDAPAGAASYEATATNTRQPVKRRRRDAAASGYHVQYVGSRTNTPLQHGTPIGSTLSSDRTNSFLNTTAPTSLSSNSQYDEAPVPLKRKRTTRQQAANEAKRRDVDGLGGRLLTYKPPPFPPKKVADVQVRVVHDHYSKNVKVDDDDGHYIVVPDAELTEKYQITRLLGQGTFGKVVQARDQKRNQAVAVKIIRSVQKYRDASRIELRVLATLKANDANNRYRCIHLTDCFDYRGHICIVMDLLGQSVFDFLKGNGFVPFPNSHIQNFARQLFTSVAFLHDLNLIHTDLKPENILLCDDLYQTFTYNRKIPSSSTTINRQASQRRVLLNTEIRLIDFGSATFQDEYHSSIVSTRHYRAPEIILGLGWSFPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMEAVVGSRIDTHLVQSVNKMSTRSGGNPASKYFKRLKLDYPTADTTRGSRRFVKAMKHLHDIIPSSNQFFKHFLDLLQKIFVYDPARRITAKQALNHPWFDEIAQPDDGTEAAKIRQERKRLEQEKARAHHHRYVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY39</accession>
    <name>A0A7D5YY39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Urea active transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g060780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544647.1">
        <property type="nucleotide sequence ID" value="XM_014689161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY39"/>
    <dbReference type="GeneID" id="26243059"/>
    <dbReference type="KEGG" id="mbrn:26243059"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="72690" checksum="9B60BBF78CB43E52" modified="2021-02-10" version="1">MSSPGPALSQGFGYGIILGVGFAFAIFMVALTHILKRFNNEVQTSEMFNTAGRTMKSGLVAAAVVSSWTWAATLLQSSGVCYRYGVSGPFWYASGATVQILLFATLAITLKKRAPNAHTFLEAIKARYGPPAHFTFITFGLITNVLVSLMLIAGGAATINALTGVHAVAAIFIMPVPVVAYTFVGGLKATFITDYIHGFALFIIIITFALTAYATSDVLGSPAAVYDLLVEAAARHPVAGNQDGSYLTMRSQGGAVFFVINIVGNFGTVFLDNGYYNKAIAAHPVHALPGYIMGGLAWFAIPWLTATTLGLSALALESSPRFPTFPNRMTEAEVSAGLALPYAAVALLGKGGAAATLVLVFLAVTSSFNSELVATSSIFTYDIYRTYFRPDAKGKHLIYMSHVCMVVYAAVICCISVGLWYNGISMGYLYLLMGVLISAAVLPATLTLLWRGQNRWAATASPILGTACAIVAWLVTAKKTCGALDVVCTGSNDPMLAGNVTALLSPVVFIPVLCLVFGLDKYDWQSMMDIRRADDHDMLENEGLDPEAQRVAEMAEQANFDQEQRKLDRAFKIACIITISMALSFLILWPMPMYGSGYIFSKKFFTGWVTVGIIWIFCSFIAVGLYPAWESRDTLVKVVRLIVTGKRPQPVLVAEQETSADSSGTATPTKSGSVSKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYG5</accession>
    <name>A0A7D5YYG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ATP23</name>
        <name evidence="11" type="ORF">G6M90_00g013600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Peripheral membrane protein</topology>
            <orientation evidence="1 9">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985728.1">
        <property type="nucleotide sequence ID" value="XM_066129748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYG5"/>
    <dbReference type="GeneID" id="26238606"/>
    <dbReference type="KEGG" id="mbrn:26238606"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="31981" checksum="02517B6A7DA6C5B7" modified="2021-02-10" version="1">MASSSATPPSTSTSTSAAAAASLQVAAADAPSDGKLPARPKQLVNDPARTGFDPETKWWMNYFKILSNQMTPEGKFHYREWRYKVHEERDCKRCEEYKDWLFTYSPVVRFLSDKIQDLNGKLDRSNIHCRRCPSVLEEDGTVNRQAGGFDPNHGILICANEVRDRKHMEDTVAHEMVHAWDHLRWKMDWVGDKDLKHAACTEIRASMLSGECRWTREAFTRGQWSVTQQFQNCVRRRAIQSVMARPRCKDDVQATKVVNEVWDSCFSDTRPFDEVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYS6</accession>
    <name>A0A7D5YYS6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g033970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543324.1">
        <property type="nucleotide sequence ID" value="XM_014687838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYS6"/>
    <dbReference type="GeneID" id="26244125"/>
    <dbReference type="KEGG" id="mbrn:26244125"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028816999" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="129"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="39091" checksum="5FAF4C39D9528B5A" modified="2021-02-10" version="1">MILPSLTAALAFSAVVYGHPETEEERQAQAATLRRIAAHSKRSLANCADSPAAIALKERAVARRAAWADELRVKRGLKTRAERRGPKELEKYLDLSHNETAKGYNLDTPLDVLFGSNASCILVPETIIGPYYVEGESFRTDVTDGEPGVASHLDFQFIDINTCEAVPNLIIDLWHANSTGVYSGVTAELQGGLKTNFGRGIQQTDKDGVVQFSTIFPGHYIGRTNHFHVMSTDNATILSNGTFEGGTVSHIGQVYFDQSLIAEVEKNEPYIRNQQPVTNNRQDEFTGDEATEDYDPFMKYTYLGDGAEEGLLLWLTIGLDITTNYNANVSVASKWHPGGGTDEGGRPKEEEKASFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYY9</accession>
    <name>A0A7D5YYY9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g023920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985821.1">
        <property type="nucleotide sequence ID" value="XM_066129919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYY9"/>
    <dbReference type="GeneID" id="90967509"/>
    <dbReference type="KEGG" id="mbrn:90967509"/>
    <dbReference type="OrthoDB" id="5224238at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="455" mass="51830" checksum="DF6FBC4262BA7F2A" modified="2021-02-10" version="1">MNASRHSLLDHLPVELLSSIASHLDLQDFRSFRLVCRLISLRTRSLLACEEFNGLLWRPDAARLYQLSRIPECARRIRSVTFNFARLNEYKALHDSFSHHYLIEPELRSEILHDKWEQYFQTQRQKKALGEFRLDLAVEAFRSLPSLREVTLTWTRCPWDVDSEACRLFSADVSIRMAKREVFDIQDAVMRELFKAATGLDTLSLEPISMLGPNGELYPGGEPELGTCCRADEHLAIAEAPSRFDFFMALRRLSLVLDRKSELSMEAGLHAVLRQTKLKELRLEYLPWVRVRPRTSFLEGVYISELEVLEVIGPEVGLRNLAVFLARHGHTLKKLELVDVKGISCSEGTDSDSDGQLIKAEDIYVEPSAALNTEANTWEGVFAIIAERLAKLEQVRVAGAFTDPVSGGKCWFYHDAIQVGPAVPEDVWLAPARPMEKYLLRQGEMPELKFWAEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ36</accession>
    <name>A0A7D5YZ36_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cuticle-degrading protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PR1_3</name>
        <name evidence="9" type="ORF">G6M90_00g064080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540133.1">
        <property type="nucleotide sequence ID" value="XM_014684647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ36"/>
    <dbReference type="GeneID" id="26247169"/>
    <dbReference type="KEGG" id="mbrn:26247169"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029019621" evidence="7">
        <location>
            <begin position="16"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="141"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="695" mass="75394" checksum="4A3A980195D91569" modified="2021-02-10" version="1">MHALAYFAILPLVLGAVLPADSYTTTPRPGKLVPGRYTVKFKEGTPVSVRDNLLSQLDNANEHVDYNDIFVGFTKAMSETEVDLVRNDPNVEYVEQDRDVYGFGIVEQPKASWNLGRIANRKRGIDKYVYDETAGEGTCAYVIDTGVDDTHPDFGGRAKQIKSFVPGETTDGHGHGTHVAGILGSTTYGVAKQTRIFGVKVLDNNNQGYESRIIQGIDFVVNDQKKRRCPKGIVVNLSTGAAKSNIFNAAAAALVKTGVFFGAAAGNFNDDASNYSPGSDPSVCVVGGTDKDDKPFFIKGRGGQPDFATNFGARVDIFAPGQDIVSTRTGGGELTMSGTSQACPHVVGIAAYLASLEGITGTKPLCDRIRKLSTKNAIINQHPNTPNRLAFNGATLSSNRKPLCTEIKQLEFGIALSDDMFAGTNDEIGAILEGPAGKAEFSIVTDASRGFNTRVPVDMKASFGSDTIKIDGINSISLTAKGPWISLLTNDKWKVKDVTLHAKCAEPGLEVADEKYISLNAWYQHPDASWLPFTGHSKQIVAKLGVSRADWTMKPPCVEVKDITYWFQLGDKWLGGADGILSFKLGDGKRITVGENLDAGFFKSGTMDLKDIYGRDTMDLRDIKKLQIFDNVGYKGKTDEWFLQGIGFGATCAEGGQKVKLSKFGNEDEWLGDDHHYDDLVYARDIIPSDWVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z156</accession>
    <name>A0A7D5Z156_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-methyltransferase tcpN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tcpN_2</name>
        <name evidence="2" type="ORF">G6M90_00g036510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986525.1">
        <property type="nucleotide sequence ID" value="XM_066130182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z156"/>
    <dbReference type="GeneID" id="90967619"/>
    <dbReference type="KEGG" id="mbrn:90967619"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="168" mass="19082" checksum="7D2DCD8E3F2983AE" modified="2021-02-10" version="1">MSVADIGTGTGLWLLDLAREVPSSVTLHGYDISDKQFPPSQMLPQNVSLKQLDSLGDVPTELQGRYDVVHLRMWANNLSSKEVGSFICNLSKMLKPGGYIQWEDVDLCNHGIRTKQVEEFDQQMKELFKLAGRDYRYLRISMFFSVDLDSYIPTRQLDSNLALFASKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1E3</accession>
    <name>A0A7D5Z1E3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g009550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549559.1">
        <property type="nucleotide sequence ID" value="XM_014694073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1E3"/>
    <dbReference type="GeneID" id="26239003"/>
    <dbReference type="KEGG" id="mbrn:26239003"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF0">
        <property type="entry name" value="HOLOCYTOCHROME C-TYPE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="29859" checksum="F955A6F03605840E" modified="2021-02-10" version="1">MSSANKEDACPVDHKTRDAWLSQARAAEATKSQAAAAAQCPVDHTSQAQSKSWTQAITSYMPWTSASTAPATPEVKPRNAPLTTDRVISTIPRSATGSEACPVDHGASANAPNAEIESGVDASGNWVYPSEKMFFDAMKRKGYDARVADMKTVVPIHNAVNERAWQQIKQWEAPYLSKSSCGGPKLESFANKNDRMTPTARINTILGYTAPFDRHDWVIDRCGTRVEYVIDFYAGRPGAKDKAGPSFYLDVRPKLNTWEGVKMRAMRWTGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1E9</accession>
    <name>A0A7D5Z1E9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g002900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985760.1">
        <property type="nucleotide sequence ID" value="XM_066129540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1E9"/>
    <dbReference type="GeneID" id="26244166"/>
    <dbReference type="KEGG" id="mbrn:26244166"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="51"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="417" mass="45536" checksum="20DE52571BCDC8E1" modified="2021-02-10" version="1">MSSSSYSSSTSSPTPSMSAVSPPKSSFEMDDDVPPRLAADKTEPPLKKTLHTAVYISLWIFISNLTILFNKWLIDTQGFRFPILLTCWHLVFATIATQVLARTTTLLDSRKKLPLTPRLYARTILPIGIFYSGSLVCSNVVYLYLSVPFIQMLKAAAPVAVLFTSWAWRVAEPNLASFLNVLWIVAGVALASVGEIHFSLIGFMYQMGGIVFEAIRIIMIQVLLSGDGMKMDPLVGLYYFAPVCAVMNFLVAIPSELPTFTWAAVSKVGVGMLFLNASIAFLLNVTSVFLIGRTSGLVMTLTGIFKNILLILVSIIIWNTKISFMQTVGYAIALAGLTYYSLGYEQLSKLFQSSATWASGVWGATSAASRGSGSSASRRCVLISFFIFGGLFVFVAALQHYDPSTKSLKLPAWFGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1J0</accession>
    <name>A0A7D5Z1J0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cft2</name>
        <name evidence="7" type="ORF">G6M90_00g047340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544853.1">
        <property type="nucleotide sequence ID" value="XM_014689367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1J0"/>
    <dbReference type="GeneID" id="26242194"/>
    <dbReference type="KEGG" id="mbrn:26242194"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="287"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="960" mass="104163" checksum="FC4CE5A0433E8996" modified="2021-02-10" version="1">MFTFCPLQGALSESTASQSLLELDGGVKVLVGLGWDETFDLGKLEELEKQVPTLSLILLTHATASHLAAYVHCCKNFPLFTRIPAYATRPVIDLGRSLIQDLYSSTPAASTTIRQTSLSEIAYAYTQTAATAQNLLLQSPTPDQIARYFSLIQPLKYSQPHQPLPSPFSPPLNGLTITAYNSGHTLGGTIWHIQHGLESIVYAVDWNQARENVFAGAAWLGGAGGGGAEVIEQLRKPTALICSSRGAQKSAQTAGRAKRDEQLLETIKTCVTKGGTVLIPVDSSARVLELSYLLEHAWRADAASDNGVLTSAKLYLAGRNMSSTMRYARSMLEWMDDNIVQEFEAFAEGQRKANGAVEKKEGGPFDFKYLRLLERKAQVSKLLDQVASAQGEVAKGRVILASDTSMEWGFSKDVLKGLAKDPNNLVILTDRPTIAKDDRPSIARTLWEWWRERKDGVSVEQTSTGDNIETVQAGGRELEIREASRQALEGDELAVYQQWLATQRQLQATQQTGTAGSLDGPTDVVDDASSESSSDSEDEDGQQQGKALTVSATLGQAGRKNVILKDEDLGINILIKRKDVYDFDSRGKKGRERCFPVAIRRKRNDDFGELIRPEDYLRAEEKDEDNADGSHLALDDDKLGKKRKWDDVIKGANGPNKRPQPGKGVAEDGDDGISADGHAADDLDDVEDTEPEEPAGPCKLVYTTETIQAKLRIGFVDFSGLHDRRSLDMLIPLIQPRKLILVGGNHEETMSLAEDCRAALGMDGDKAVDVFTPSVGVWVDASVDTNAWVVKLADPLVKKLKWQNVRGLSIVTISGQLLATNTTAEATEPSDEDSSNKRQKTEPSTAVALTSTALANSSGVLPVLDVIPSNLVSAARTAAQPLHVGDLRLADLRRAMQGSGHGAEFRGEGILVIDGSVSVRKTAEGRIEVESVGLPVVGRRNTLYEVKRAIYDNLAVVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1J4</accession>
    <name>A0A7D5Z1J4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLD_1</name>
        <name evidence="19" type="ORF">G6M90_00g042590</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547595.2">
        <property type="nucleotide sequence ID" value="XM_014692109.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1J4"/>
    <dbReference type="GeneID" id="26240158"/>
    <dbReference type="KEGG" id="mbrn:26240158"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI66847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="550" mass="62891" checksum="28861CDD0520A091" modified="2021-02-10" version="1">MSRNEIESRIAGGQKIVIFNQYVLKVDPWLPYHPGGEKALLHMVGKDATDEIQALHSKAAQEQMMRYRIGKIDGFWTNFRPPIQGGAFRPSLDANNVDCEELHNRKMLASSTPISRSPSPVFDVDHDGLRRRGHDEDHPTRTASISSQSSVEPDTTGMSYLDALTREQVSLDIDKYPGVDLVTQHEIAAKYKRLHQAIMDEGLYECSRTAYVFECCRYVGLFAAMFICLIYRQYVLGAVFLGLAWHQLVFLAHDAGHMGITHDYQIDTAIGIFVADFIGGLSLGWWKRNHNVHHIVTNAPEHDPDIEHIPLFAVTHRLLGSLRSTYYDRVMEYDAFAKFMLRIQAWTYYPLLALGRFNLYRLSWDYLIARRGPRRGPGAWHWYLEIAGQFFFWAWFGYGILYKMLPDGWTRFMFVMVSHVTSSPLHVQIVLSHFAMSTSDLGPQESFAQRMLRTTMDVDCPPWLDFIHGGLQFQAIHHLFPRVPRHNLRKAQRLVVEFCRDVGIPYALYGFSDGNKAVIGRLSEVSRQAAILAKCQQTVARNGGVFGHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1K4</accession>
    <name>A0A7D5Z1K4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">spk-1_0</name>
        <name evidence="12" type="ORF">G6M90_00g001680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542908.1">
        <property type="nucleotide sequence ID" value="XM_014687422.1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    <accession>A0A7D5Z2P7</accession>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="651"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="651" mass="70896" checksum="88AEF195D8D33C28" modified="2021-02-10" version="1">MGPNKAIAAAIVAFAAQTASAKPVDIQPKIIGGWEANQAEWPWIVSIRLEYPGGRHRHICGGTLVSPDTIVTAAHCNQDRLRPGLFSVLAGSNDRESREATVVGVAQIIDHPRFSTETMQNDISVWKLSRPIPESNTIKYARMPRQGEDLPRSAAVKVAGWGAIRDTRNKPQGAQGILARDAPQEPSPKRWVPVITPGPQPRPPVDETMSPFLLREASLSVVDLNSCIEAYISASKSKRGQFSKSFVPQFAQTMMCAGVYGGAQDSCYGDSGGPLVDANSKALVGVVSFGLACGHPKAPGVYTKVSSYLDFIRRVAGNIGGNGDNGNGNGDNNNNSDNGDNSSGNGDDDGVTQVPPNNYNYCRHLIGQFLLTAGNGVVIQYVASADYQVRNYISSVHFIGNVVQFDRPLLGDTTGLNCVHLQCHIGTDMLGLARLGAASVTGLDFKFWGSNYSGAQTGRFDGWRRRREAQGLTVLPRDTFDLVFISIGSVCYVAKIKEWARVVSRLLKPGGRLFVREFHPVLLSLDDGKPDEMVFNLPYFEREEPGIMDKQGTYVSSGDCIFTLTKRALFNHGIREVVQALLDEGMKLTGLREHQRAPLTGAQAELEVDQRGESQVKEKPLARRIYLHRRLLFEASTVAIALSYTLLAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2S4</accession>
    <name>A0A7D5Z2S4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NPT1</name>
        <name evidence="11" type="ORF">G6M90_00g025410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548042.1">
        <property type="nucleotide sequence ID" value="XM_014692556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2S4"/>
    <dbReference type="GeneID" id="26237486"/>
    <dbReference type="KEGG" id="mbrn:26237486"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000009">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="184"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="464" mass="52214" checksum="368E24242BBDC4F1" modified="2021-02-10" version="1">MDFNSSSPFPEGVISFLDTDLYKLTMQCAVFKFFKDVPVTYAFTNRTPDKKLSRVAFKWLDEQIRKLGNISLSNGEYQFLKTHCTYLTDDYLNYLRDFQLRPREQVTVTFTTVGKDSGADSDIGDIDIKIQGTWSDTILYEIPILALTSEAYFRFMDTDWNYDGQEELAFHKGMQLLEAGCITSEFGTRRRRDYHTQALVFRGLVKASKAAAEKGFPGKLSGTSNVHLAMRFGIPPVGTVAHEWFMGTAAIFDDYKKATELALRHWVGCFGSNLAIALTDTFGTAEFLHSFSLPVQTVEGGMSGDIFKNEDGSTKTYAELFTGVRQDSGDPAEYAKLMRNYYDKQGIKEKKIIVFSDSLNIERCLEYKKVSEELGFQPTFGVGTFLTNDFTHLTTGTKSVPLNIVIKLSSAAGRPAIKISDNIGKNTGDKDLVEKVKKELGYVEREWKEGDETSRWGKEENAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2S5</accession>
    <name>A0A7D5Z2S5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARG82</name>
        <name evidence="5" type="ORF">G6M90_00g046190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544747.1">
        <property type="nucleotide sequence ID" value="XM_014689261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2S5"/>
    <dbReference type="GeneID" id="26242088"/>
    <dbReference type="KEGG" id="mbrn:26242088"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="361" mass="40168" checksum="30EBB771D84C91BD" modified="2021-02-10" version="1">MQPARDVPRFDQLQDYPHAVAGHAGTLCDSDGQVFVKPCTQAEIDFYELTKSKYPDFADLMPLHIGNLVLSGPGEMDIGDIGDGLQTDPEQVLATIQEQVANAARESQTEDTITWVPSQGKKIQTNMSVVLENQTNGFKRPNILDVKLGTRLYADDAPKQKQQRFQQISKETTHHNLGFRIAGMRVFRGSQDPSELDDREYKNYDKDYGRFTVNDDNVVNELKRFVFNEAAGIDEDLGKAVCATFARELGTIIDVMSDHNIRMYSSSLLFVYEGDGEALKDAIRLNTEYAKRSTGPPATKRIDSGIGLDDEDQALEQLPPPVLKLKLIDFAHATWTPGSGPDENTIKGVSSLEGFFKEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3C0</accession>
    <name>A0A7D5Z3C0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g019800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985999.1">
        <property type="nucleotide sequence ID" value="XM_066129843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3C0"/>
    <dbReference type="GeneID" id="26238007"/>
    <dbReference type="KEGG" id="mbrn:26238007"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028848863" evidence="3">
        <location>
            <begin position="23"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="455" mass="49513" checksum="AD21BDBF80FC70F5" modified="2021-02-10" version="1">MLSKCIKLSLVLYAVYIGRVVAASRRDNQTICDYYAEKVFGESNVATQLRLMQGIIAYAYAGGDTLPDPNPNSTGIFNKGKFNGYDVFLRPLFDGSKATTNFRDQPVPINWLDGGGLDPLLAFLNGSTVFAKIEPDSNQEILFSHWYVTFGKVYQCSNASVFVAKEYAPFTPAYVHKFMNLNSTEVAYFIDQLMLASKYYNFSDSDAQQLAATLNTKYNNKCSPPDDNGQLNSVCYADSCPEAVPKKDCEAYKNLEPYGFKASTPTGTATGVIPTMSSSPNSSATSSGEVAGDSSSRLSAGAIAGIVIGGSVVILMAVGMWLYFRRQQQNKPAETPAAAQNQMSEAASPAPAYSSQVPYSHPHDSYYSRGPHDSYTVSTIGSPVSTAATWEQSKLPQLQEMAAESPSPPPGTLSPNNQGDRCTRLRRWKVLIHRLPGAKTQNHNGVSNRIDYLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3C8</accession>
    <name>A0A7D5Z3C8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphofructo-2-kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PFK26</name>
        <name evidence="5" type="ORF">G6M90_00g034280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546825.2">
        <property type="nucleotide sequence ID" value="XM_014691339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3C8"/>
    <dbReference type="GeneID" id="26239388"/>
    <dbReference type="KEGG" id="mbrn:26239388"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="271"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="691" mass="77707" checksum="F822E5400093E727" modified="2021-02-10" version="1">MPSAVALPRQDVSVRLRQAKQSELAKLVMQNQFGVASSRSSTSPTSSEPEQHFAVQPPSHSSDVASYSYSPLQSHGTTQCYSMSAPVAIPTMASAVRMMKDLTDTPPLSQSVNSTAPSSPRIPPLRQNSGSQTPRVRPHATTLNIPGMTRSRVSPDGRIPQRDVAAKLVIVMVGLPARGKSYITKKLQRYLSWQQHESRIFNVGNRRRNAAGIKTSARANSGQARRALDPPVEAATILLNGVPATNNDIPPDQAEPTTLNLNSTNGEPQEEVDQSARFFDPNNEKAAAMRNQVAMETLDELLDYLLNQGGAVGILDATNSTIKRRQQVVDRIREREPKLGILFIESICRDPHLLEANMRLKLSGPDYRNKDPIKSLEDFKARVAAYASAYVPLGEYEEDNDLQYIQMVDVGRKLIQHRLKGFLSGGISTYLSSFNLSPRQIWITRHGQSVDNELGKLGGDSILTERGHCYGLALYKFMTQKRKEWLMEQKSKLAQATFPPHPGDNTPPYPDMHKDLDEKNFCVWTSMLQRSVETAEYFDADDDYDVKNWEMLNELNTGQFEGMTYDEIARKYPEEFHKRAADKLNYIYPGVGGEGYLQVISRLRDMVREIERITDHVLIIGHRSVCRVLMAYFMDLTREDITDMDVPLGMLYSIEPKPYGIAFHAYKYNEANGWFDEMPNYRPQKAARGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3M6</accession>
    <name>A0A7D5Z3M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g029950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539710.1">
        <property type="nucleotide sequence ID" value="XM_014684224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3M6"/>
    <dbReference type="GeneID" id="26247467"/>
    <dbReference type="KEGG" id="mbrn:26247467"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="441" mass="49329" checksum="4B0359BF18E57DC4" modified="2021-02-10" version="1">MSPHPWLSLPSQLGSCLCKLTESLATDSRFQAFCNLGPGAKEFAFGWKAAGSDSVIVCHVKPGHVSVAPGSEAEANFILSALPEQWEQFYKPIPVAPYQSYWGMVGQNIHQDGVDIMGDQNMFVAYASIWRRVLEMSHEALHGRMQEDPVPPPSLEDAIVGRYVYVSPPGWGRTKVFYEQSGSEQHRDILFLHTAGSDSRQYHGVMNEARMLAKCRMTAFDLPGHGRSFPPETQIPGCYTNTEETYVGCIKEVIRALGLKKPIVCGASMGGHVCLAIALRAEELDVGGVIPCQGCDFTNMDRQWWDRSVSVNQSLSNPEWIYGMMAPTAPRINRDMVWHCYSSQAFGIFHGDLDFYYGGWDGRTRVKDIDTDKCPVYMLTGEYDWSTTPELSEKTALKIRGAKFTKMLGLGHFPAAENPHRFVTYLVEAIDFILFQQVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z420</accession>
    <name>A0A7D5Z420_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dual-functional monooxygenase/methyltransferase psoF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">psoF</name>
        <name evidence="7" type="ORF">G6M90_00g031340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543073.1">
        <property type="nucleotide sequence ID" value="XM_014687587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z420"/>
    <dbReference type="GeneID" id="26243874"/>
    <dbReference type="KEGG" id="mbrn:26243874"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="720"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="909" mass="101691" checksum="8AA59BA3BB827FAC" modified="2021-02-10" version="1">MSKRVADYDAVVIGAGFSGIRSLWELDQLGLTVKCFDAASDVGGTWYWNRYPGSRTDGEAWVYILNFAPDLLEEWQYHERYPTQEEIQRYLSRIADRYNLRKYIEFDTRIAAASYSDAENIWTITTENGLSTTCRYFLPATGILSIPKKPPFPGLSSYTGEWYQASNWPAHEVDFHGKRIAIIGTGSTGIHLLPKLAPIAKDVTVFQRTPNYVLPGRNHSIDEYQVVDIKKNHEATWELAKMNIAGAACKASGRTVKSVGDADKVRQILDHGWERGCFNFQLETFDDAFMDPESNEQVSEFIRQKIRAIVQDPNKAELLCPKYPFGARRPPSGHFYYEAFNRPNVNLVDMSRDEIDLFEKGVRTNSGAEYEFDMIIFALGFDAGTGAMNQIDIKGSQGKVLKEYWNAERLGTFAGVLVSGFPNMFIVCGPHMPAGNLPVPLELSVNWIGKTIRHMEENSLAVINVREDAMHAWSDHHDGLWNSVFISQPAKENRSWFVGTNIPGKPANIMFYFGGVQNWLLWLNKELDTNWESMEFTPLSGTDKTDQDAPGQTSSSTTSSITAEMLESAVMPLQSDQVGMTAAEKFNLGSAACARYIDWAVKEIHDRGLAVKQDHRAYWWQVLQDFVKSESGQVLIQQGPSTKSEMDQLTSRLGIEGEAIHRIGPELVRMLTGQTHPLALILRDDLLFRMYHSDEGARPNQYMADYAKFLCSKKKDLRILEIGAGTGGTTLKVLQACSPDGEFFCSEYMYTDISPGFFKTSQTTLKKWERVLKFQTLNVENDAAKQGFEEHAYDLIIAANVVHATQSLTRSLGTIHKLLKPGGKLGLVELTRLTPYFNMAFGSLSGWWAGVGEGRTESPLQSPEQWGQHLKSAGFSGVDLAAYDLPEPESHSALLVSTALAVDVATNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4B7</accession>
    <name>A0A7D5Z4B7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g008410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549666.1">
        <property type="nucleotide sequence ID" value="XM_014694180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4B7"/>
    <dbReference type="GeneID" id="26239110"/>
    <dbReference type="KEGG" id="mbrn:26239110"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028877535" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="107"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="451" mass="48941" checksum="3B378BAF78F75C02" modified="2021-02-10" version="1">MVLVRFFLYIAGARLAVTAPNVPVQPPSTSEWDLSKPLNGFTFQLAKARSAAPTIDKPALLYSRITSIKGSSSNQNAVSSLVQILQTPPSHGQHTYQNISTTGNLSTQYAIQCGWDGAPVWLLLDTGSADTWAVQTGFECHDSHGTKHNQAACAFGNPHVKKFQNGPIDGLHFYLKYGSGEKVFGPMGYADISCGGVSVPRQQAGLANYTYWHGNNLTVGILGLAYPSITSAFYGEIGQEAAWNAIQYVPFLTNAIMQGSIDPVFSVALAKNSSDGIIAWGGLPRVQRASDVYAETDLIIANLVGSAETSWRYSFYTIIPDGIIWGQRMDKSKFPYIVDTGTTMNYLPPPLAEAVANAFLPRAVYLYQWGSYFAPCDAVPPRFAVVISGIEFWLNPADMIYRDLVDPMTGYCAVAITSGGSGPYILGDVFLQNVVAVFDIGGAQMRFYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4G6</accession>
    <name>A0A7D5Z4G6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">tcsA_0</name>
        <name evidence="18" type="ORF">G6M90_00g045670</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544695.2">
        <property type="nucleotide sequence ID" value="XM_014689209.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26242036"/>
    <dbReference type="KEGG" id="mbrn:26242036"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="69"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="1974"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2248"/>
            <end position="2372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="535"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="702"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2470"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2470"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2510"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2552" mass="280881" checksum="2F415213F445B7AD" modified="2021-02-10" version="1">MDGAVLVPDDVLDSRPPPPPRLFERLRQIAGYTWDETKEPIHSSYDFWLVFGTRFVSSKPSPPSSGHNESSLGSITKLQFGRPSPSEHGNHVPPSETQSTETPKTPLPHRPSTPISSPPSSADGPPIVEESVVARVSSHNLREERAFQIAKNVAGTADPLGEHIAKPIDLLRLNPGPGDRNHITVAIYQYPGANYLGKVLDFGPAFYQARKEGDAYVSYRPATSSHLRPPINLEYFLDFAIGAVQCLEILHHGQGIIHGEIRGDAFHFNAEENKVRIVAFGTGLRSFEHGLTSTGWLTLSKEVGVKNKLLYISPEQTGRMPAEPDTRTDIYSLGILMWTLLTQQPVYAGDTPMDIVQGVLGRRVPNVATVRMDIPDVIGRIIQKCTAKNVADRYHSASGLRHDLVKVQQLLSDGDSTALKDLEIGTKDISSFFILPTNMIGRTTEQSELVKVIDRVSRNHSLGSNRNRFPDGSGLANELVVLDDVSSEGGASSVRSVEGTNRRSGSFNMGGGSSEYKFPRNSFHPSILSDTQTLSNETVSSNQSGPQLRPTRPWERHHSISVETASAVESTGGPESGRMGGMTESSGSSLSRQLGAAKFRRRGQCEVVAIEGAGGLGKSFLVQSVLGEARRRGYCATAKFDTARRTAFGPLLKLLSSLFKQVWGETNTETPFHQVLKQYVRPVWPMLHRVLGLPEFLLGPPESASPMVGRPSTNNSQQAGQRSGVKSSSGKRRGSSPGSSPSPLSQHQAANAAAAATAGSQSSQDYLCAGTSTKTTRLMNTCLDILRVFTTHKFICFCLDDLHFADDESLELITQIIGAKMKMLIIMTYRPEELPRERMDKIIYPAQLEENHRNGRPRVTRISLEPLSEAEILDYVSATLSRPKEEILSLALVIQAKTAGNPFYMREMLSACHRKKCIWYDYRDSIWHFDLDRLFAQFQGEKDYDVLDTGFITRRLDELPSAARAVLSWAALLGNSFSFEIISRLMKGEFDYGDDDIPNCCPNLSKRSYTEAEAIAGLQAAIQAYIIVPSETDDRFRFAHDRYVNASAALKECNARRMHFIISQTLLKYYAVEARQRESTACHICEAASIIKMRVPVRQEFRKLLIDCAQAATENGARPTAAKYYGAAIQLLQGDPWSDDADDASYEETMQLYLRAAECHLFMGQLSLANDLLSTLFANAKSAMDKAPAYVLQSRIFAQNGNSLAAFISLKECLAALGVPLEDEPTYEKCDKKFHKLAKQVQEMDREALMNPKKNTAPVTASIGAVLSETASAAWWSDCLQYYHLTLVMLDMHLTRGAFPQSGMAFLQMGVVGLARFNMTQFAVDMGTICQDLLYSARDAFSMARGQMLHSCFIGHVQYSMSLSTSQMDDAIELASVGGDRLSTILSYGLCAVTKFFASENLSDLEAFCQYGCEDIVNWSLDTRGGALLVAVRQLSRALQGKTCTHEPLRVMTDDQHDSVGYKSWLTSQTQESNRSSLFYESLELCALFLYGHYERAIDIGQKCVEKLPMLWSARNSRLILLFYGLARAGQLLRLMQDPRSQTDDFTAQTEEIVNELTGFVKMMEDWSVVSDVNYRSWSRLLNAQVAELSQDHGQAIQHYEEALDHAAEHDFIFEEALGNYVMAGFFIRRRARRSARAALQDAVGLYRQIAAAGVASAIEEEHSLLLHGPTRNHRTVEVGIQTDFVADPPPAQYRPVDGVDGEELTQVPSNAMSEFRGERIGAWRGSMRMPTEDGVGLPALDMIDLHAILVSSQVISSVLQVNELLKTMCDVILQTCGGSATRAAIIIQDNDTESWCVAASGDPERGASAHEPGLPLSGSTLIAENVVLYCTRFRETVFIPDLFADERFGNVNGGWLQRYPGGKAIISIPILHGTKPLLGVLYLEGEPGSFTDRNVTVLQLLVNQIGISYSNALSMKNVEKISAENRGMVSVQKRALAKALEAETKAKHAEAEAKRNVKLAEEAAKAKAIFLANVSHELRTPLNGVIGNSELLRDSDLNREQLEMADSIRVSADLLLTVINDILDFSKMEADKMKLYIIAFNPEEMVREVVRAVSYSNREKTSKKNVKIIQDINLPPMLIYGDPIRLHQVLGNLIGNSLKFTEDGSVTIGARLDAETKDSATLTFWVRDTGIGIPAQQLAKLFQPFSQADASTARKYGGSGLGLSICKSLIEIMMKGKIQLESEESEGTTAWFTVTFEKAKADVSAGDALGKASPPIDRYSLMTSPFDRVASPNPFMDLSRVSKEDVRICVAEDNPINQKIAIQYAHRLGYPNVVAYENGLKAIEGLRKKAAEGEPYHIVLMDVQMPVLDGYEATKLIRKDSIEAVRKVLVIAMTASAIQGDREKCLAAGMNDYLAKPVRSEVLKKKLDAYVDVSKAGVIDTVQSPISPISPTTPNDLEANGTSLASIASSNKVFRDTRAPNSSIIDPMQEDAVYNMPLDSTSLQAADSPVLSANNNDQRTLSMHLPELTRNSTNHSDSQPSTEASTPEAVSTGDPVALQPKRQPRKLTKTRDNSDAHWDAEAKPIDKDREKHKGVLTKKQPLADDPDGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4L6</accession>
    <name>A0A7D5Z4L6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gelsolin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AM</name>
        <name evidence="3" type="ORF">G6M90_00g055130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540893.1">
        <property type="nucleotide sequence ID" value="XM_014685407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4L6"/>
    <dbReference type="GeneID" id="26246199"/>
    <dbReference type="KEGG" id="mbrn:26246199"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="193"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="318"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="399" mass="43169" checksum="82787FB7DB0215D3" modified="2021-02-10" version="1">MPPNHGLVHAKEYDIKDSNVELIGSDIDHRVKHKSAATEPAWNDGAVGTKPGLRVWRIEQFQVVPWPEDQYGQFYDGDSFIVLHSYPLGKASSSSAKLGHDIFFWLGSHTTQDEAGTAAYKTVELDEFLSGAATQHREVQTAPSAEFLSLFPRLTIRSGGARTGFRHVEPQAARAPVRTLLRVFKSPSGGLVVHEVDPAVGSLDDGDVFVLDVGDKIWVWQGRRCSPAEKAKAAQVVHDMTLAKHIDVEVVAQAEARSRRVTELLGGGGGDDTPRDGFSQRRPMGAAAGEAADRSARLFRLSDASGRLTFELAGDGGRISLGDLDGNDVFLLDDGGRGVWVWEGAGASRGEKAAWLSVAQAYIRHLQSGDPDAAHHLVPLAKVRQGNESRAFLRAIEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4R6</accession>
    <name>A0A7D5Z4R6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase helB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">helB2</name>
        <name evidence="8" type="ORF">G6M90_00g052760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540402.1">
        <property type="nucleotide sequence ID" value="XM_014684916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4R6"/>
    <dbReference type="GeneID" id="26246764"/>
    <dbReference type="KEGG" id="mbrn:26246764"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="528" mass="60170" checksum="AC0DFEF5A31C2EB6" modified="2021-02-10" version="1">MPLQDKLRLVQDDGFRLILTLSFLWILAKLLYAFTLSPLRSIPGPKVARITALRAIRNRLPKNVIRYALDDFHTYGDIYISKPDTITLSNPAHARAVLGALDSRKMDIYKSLSDPVMKNLVTFSEPRLASQRRRQIGPYLNSPSYLARMEQVVLQYGAVSMMHKWNEQLDSAASGDKDRDKDTRTIELNYRNDTQLATFNIMSALAFGRVDKATSDSSTVVDWIAATAVYIGISINFRILLRFPLSLLVRPWLRKYDDFVGYARESVRQRKELLDENPDDKTPADMLQAFIDAEDPDSKIKMSPLEVQAESVGMQLAGSETTSASLTWVFHLLTLYPDVLDRAVGQVRSRFGADHLISYTDCKQHLPYLEALVYETFRFAPITSGFMPRMCSKDMSFQGYRVPAGTHIAFNLMAMNNHPDVWDQPDRFWPERFLGNEDAKRNIFAFSYGPRSCIGRNLAWMEIMTILANVLNTFDIRLPEDAMYGPHNVDGNGTPVMMPSHCHIVFAPQRPDRDCRLLVSRRPTPRKA</sequence>
</entry>
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    <accession>A0A7D5Z4T7</accession>
    <name>A0A7D5Z4T7_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">G6M90_00g101860</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="89" mass="9992" checksum="EA24951E665B9F98" modified="2021-02-10" version="1">MAGVPVSSHSQPQYEVAEPVTPVGNSSRKKDEYEKAMARLSDQAFRSQKYPDPLVVRQGVDPQLYPQGVTLDMERTWLARMKAVKDRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z538</accession>
    <name>A0A7D5Z538_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g066110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684675.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246970"/>
    <dbReference type="KEGG" id="mbrn:26246970"/>
    <dbReference type="OrthoDB" id="3537340at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="29313" checksum="E98AF1C27B05B6C9" modified="2021-02-10" version="1">MAGSFDVDPQLCQHYAQFASNLDKQNFRIIYWTMFITNLIVLFFGSWVYSKAQKAVETLGTHSNQRAKVLRRYIFICLGCLAVSTVVVVMEAYALLALQFCDGEDLMSLYWSTWTMLQVGSLIAIAGVILALCHNLRNRQHPPWALALGTPVLVIAGILHLFHDCTRKRIKKLRRPAGSASDDGQEPRISQANTIENCSHEDKCSDIQAEFIGFTVEGGPIVRFTQPVAPMPQGQLLGRDNGGGSTFAFPRGMVRFETEDEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z584</accession>
    <name>A0A7D5Z584_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">taf13</name>
        <name evidence="8" type="ORF">G6M90_00g049160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z584"/>
    <dbReference type="GeneID" id="26242366"/>
    <dbReference type="KEGG" id="mbrn:26242366"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17315" checksum="98798968AB4C3A4A" modified="2021-02-10" version="1">MEPRARAGKNVVAQLLYAHGDVKNPLPETVRVLDEILTDFMQSIAFEATRAAHYSGRQKIKYEDFEFAFRKNPAFLGKVQEVFEKQKEIKKAREILRDGEDEIMKDAAEEERRREKEDVTGAGGAGKVNRAEEELGEADDDAEAEMDALGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5X0</accession>
    <name>A0A7D5Z5X0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystathionine beta-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g099350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546412.1">
        <property type="nucleotide sequence ID" value="XM_014690926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5X0"/>
    <dbReference type="GeneID" id="26240835"/>
    <dbReference type="KEGG" id="mbrn:26240835"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19092" checksum="EBB3C5F1E3A52C80" modified="2021-02-10" version="1">MAAQTATIPVVVDGTPKSFQSRWSSRYRGATVQDLEPPAALSLNPSDAISLALLSAFEREYTHLTIVDSETRALLGYISIPHLQAQLDSGKVKPEDPLSSAMAHFQRRNRRYKVITMETPLEQLEEFFRGGQTDGPWKEEFAVITDENRRFVLGVATAQDLEEFVKRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6B5</accession>
    <name>A0A7D5Z6B5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein IMPACT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">impact</name>
        <name evidence="4" type="ORF">G6M90_00g039290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547283.1">
        <property type="nucleotide sequence ID" value="XM_014691797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6B5"/>
    <dbReference type="GeneID" id="26239846"/>
    <dbReference type="KEGG" id="mbrn:26239846"/>
    <dbReference type="OrthoDB" id="514070at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF4">
        <property type="entry name" value="IMPACT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="252"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="55186" checksum="4C6E0057A9642C9C" modified="2021-02-10" version="1">MSGHGDLQELLRLFTSRKVPMMAAMGHIKALQAKNLRSIEQIAEAPLSAVEAAISDAKLAKSFHTACKTHGKKATKRAAEESTSPTSKKPRLEPHKRDLDYSSMSAEELESSLSLPLVEDEETIRKTTLVTNRAPLVLAFAVELLRFTMPEQPPSSRLSLGQAVVSANSRSKAISIGIEKAPPGGEEQVPEGQPKVRVLGREIPVLKRSGYSWKSDQLEDKATGSTEGHSKPESSSPGEKKAWVASQKLTSRASTFVAHAASLSSPSLRTSLMNGLMTDKPELETATHNAWALRTSYGNSPLVQEASFDDGESGCGKFMLQTMREAHVTNTLVVLTRWYGGIMLGPDRWRLMRECINDALSSRGRKSTLAGEALWGLDPENKTPSLTTVGMPIHRPEGARNYLLRSFGTAAVDGGGSETKKTLTAVSDEKQENLGRLLGALRLLYKSWAGVLRKDELDRRAWSWYVSVRPDVEAGPSGWGAKGHLNLGKILDLRRAEGSAGAKKLAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6S0</accession>
    <name>A0A7D5Z6S0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Extracellular serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g107270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544113.1">
        <property type="nucleotide sequence ID" value="XM_014688627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6S0"/>
    <dbReference type="GeneID" id="26243500"/>
    <dbReference type="KEGG" id="mbrn:26243500"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028884299" description="Extracellular serine carboxypeptidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61889" checksum="ED08DDE8050776BC" modified="2021-02-10" version="1">MRASSCINAATSLLLATLSAARISRRHHLNRLSSRSPKEYSRRSDIPTQEGTFQQLIDHNNPDLGTFTQHYLYNAEYYAGPGSPIVLNTPGEDVVDGFYTTNNTLPGLFAQTNNAAVIVLEHRYWGKSSPYDSLSTTNLQYLTLENAIQDLIYFAHNVQLPFDVDGASKPTKAPWILTGCSYPGALAAWTHHLAPGTFWAYHCTSAVIEIISDFWQYYEPIKAAMPTNCSTDMQRATEKIDKVLSHGTKTQKHALKKTFGLEALTHDNDFAESILGGLEEWQGMTFARSDKPNLLYQFCDYLENMCPDKDNTTNDCRTTPPGPEGVGPSRALDGFAKWSREVYLPGVCAEYGYWSDNNTVACLDMNDKNSPLYKDLSVNNTLNRQWYWFLCNEPLEFWQVSGPQDTTGIVSKYLDVEYGRMQCRNLFPRQGIHTYGLAKGRNVGQTERRMGGGWHHVDVNTTRLMWVNGEYDPWRPATVSADARPGGPLQSTPEAPVWVIPKAAHCNDMLAEEAVVNPELGQIVDEILATMKAWVDEYYKKGQDTRSRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z776</accession>
    <name>A0A7D5Z776_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g044860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986584.1">
        <property type="nucleotide sequence ID" value="XM_066130360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z776"/>
    <dbReference type="GeneID" id="90967688"/>
    <dbReference type="KEGG" id="mbrn:90967688"/>
    <dbReference type="OrthoDB" id="3527261at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="241" mass="27067" checksum="FCA2E3BEFBF5165A" modified="2021-02-10" version="1">MAKTTQQLRLEIDRCQCCVTRCRAHSQVKYQRLGVYDVHHRLTANNAPRKDLLKAYGTAVIVFAYRVSQVVVRCVAIRRLSTYMKSKEAFSYVSMLVASHDNAMDGSLFVGDCGIMDTLFNKPMSAVPENKAVHWATSWFQTWMAAITFVAAQQGWDGVWCSFLVALVGVQWVVHSTPRGPSLVRGWPDGEEFGGRFAVLGAIQGFTGSNVHDEMLAFSTLVTRDGLIDNNVRQYWHLPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Q7</accession>
    <name>A0A7D5Z7Q7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g059580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986656.1">
        <property type="nucleotide sequence ID" value="XM_066130682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Q7"/>
    <dbReference type="GeneID" id="90967827"/>
    <dbReference type="KEGG" id="mbrn:90967827"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="73" mass="8078" checksum="D919BF2B42C0A9A3" modified="2021-02-10" version="1">MPTVGIDIQDIESVSSVNSDEVGRIKMQSTLGKPSTLRVDGKVPDVVYSLHLLDMRNQVVNHLQSDKPFDKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8R8</accession>
    <name>A0A7D5Z8R8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein PRY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRY1_1</name>
        <name evidence="3" type="ORF">G6M90_00g090120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI71646.1"/>
        </source>
    </evidence>
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</entry>
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    </evidence>
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</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541703.1">
        <property type="nucleotide sequence ID" value="XM_014686217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9X8"/>
    <dbReference type="GeneID" id="26245566"/>
    <dbReference type="KEGG" id="mbrn:26245566"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028963832" description="Glycosyl transferase family 25 domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="6">
        <location>
            <begin position="71"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="393" mass="43749" checksum="617E77BECF6FFC56" modified="2021-02-10" version="1">MRVSPEHFFRVLAPAAVLLLLSLALLKSSVPVQWPSTPANLSALEEQRRPSGQFAGASRRDAGNGTLGFSGIYFINMKKRYDRLDALALQCFLSGVEVKEVPAVEPDMMSDAGMPPSKSPSSVKVGERGAWRAHANIWSTVLRNNLPPVIILESDATWDVNIRSIMLNMNKHFHKFLTNINSTRLHNPRWRDDAGESVRRTEAADDTWQSDHWDILSLGHCHDSAANRNISLIYDDPYVPPGKEFGDTVLGRQRVIRKAGGIVCTTGYAVSQTGAAKLLVKTAQNLDAPLDLIVRSMVEDGELVAYSVMPPIMAQWQYVDGIGMDERGANSDIQGAQEDEDKDEGEEKKDSWEEVDRSGSVWTTKPYHEDVAFQDMALEVAWRRIFGRNNEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAG4</accession>
    <name>A0A7D5ZAG4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RLA2</name>
        <name evidence="6" type="ORF">G6M90_00g085830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541142.1">
        <property type="nucleotide sequence ID" value="XM_014685656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAG4"/>
    <dbReference type="GeneID" id="26246131"/>
    <dbReference type="KEGG" id="mbrn:26246131"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="11019" checksum="338A2905E76CAE84" modified="2021-02-10" version="1">MKHLAAYLLLGLAGNNSPSAKDIKNVLSAVGIEADDDRLKTLLSELEGKDVSELIAAGSEKLASVPSGGAGGAAAAGGAAAGGAAAEEKAEEKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC21</accession>
    <name>A0A7D5ZC21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cdc37 Hsp90 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g112340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540300.1">
        <property type="nucleotide sequence ID" value="XM_014684814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC21"/>
    <dbReference type="GeneID" id="26246894"/>
    <dbReference type="KEGG" id="mbrn:26246894"/>
    <dbReference type="OrthoDB" id="10361688at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="2">
        <location>
            <begin position="183"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="341" mass="38376" checksum="B3F7DC802ACD0BA6" modified="2021-02-10" version="1">MADGKKRGEWEVSNYTQINLDLRMDSPSFRRAMREMQAKIDQDGRGRMKQIDALKEECAINDILMVHWNDLVKTRRQIHNQAQTTLQAVVNLASRKASENGRLPRPEGALDESQCLSIRSSAILGTLRSMEEKTDKYQLERSLRACDPCIQESGNELCLKMNRLEEEHRMKTTMENYYIPLDSPHASEAKPGKTDKPELLNPNRDPNQTTAAPDTCNGIEALFPKHKGQDSPSAAAMEFANILPSGPHASRDYISLHPEILDGFESTGLFIVAVETALGGTDDEKAWRLVHQAEVLDWCRALGPDDFTECFDKEIVLDCDIYMNFLMAAKEREVFADSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC56</accession>
    <name>A0A7D5ZC56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase lepI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepI</name>
        <name evidence="5" type="ORF">G6M90_00g106220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539612.1">
        <property type="nucleotide sequence ID" value="XM_014684126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC56"/>
    <dbReference type="GeneID" id="26247609"/>
    <dbReference type="KEGG" id="mbrn:26247609"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF4">
        <property type="entry name" value="O-METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27484" checksum="B45D4937B694063E" modified="2021-02-10" version="1">MPDFLEKHSYSEVNDVTKGIFQDAFTTSLSCYEYLAQNSKLQGYMQEAMSLQKPEGDWASALHIDEAVQSWSISEPTRILFVDIGGGLGHQCIRMRETYPDIAGRVILQDMPITIGRLPKPMPHGIEAMEHNFDNLQPIKNAKFYYVRNVLHGLPDSNCISMLKKIAPSMNAESVLVIDDIVIPDIGARSQACQLDFIMMASIAGMKRTRQQWHTLLKAAGFNVMEIRTYSEPLQDSLILASLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZE05</accession>
    <name>A0A7D5ZE05_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trichothecene biosynthesis transcription regulator TRI6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRI6</name>
        <name evidence="2" type="ORF">G6M90_00g106240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539614.2">
        <property type="nucleotide sequence ID" value="XM_014684128.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZE05"/>
    <dbReference type="GeneID" id="26247611"/>
    <dbReference type="KEGG" id="mbrn:26247611"/>
    <dbReference type="OrthoDB" id="4936203at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="283" mass="31675" checksum="1872D5E05FE21649" modified="2021-02-10" version="1">MDNSPTHKCALFQSGVPLLDNAELSENHTWHLQPSHLQHGPWSLPPTHQTPPFTKARNSECAPCPDNMIYPAMYPGLPESLMADQYSIKLPNSPRDNLADSAFVQDLCLESDLPFDPRSHLVDLDTMFDVRWDGASAGLASRHSYTATTEDASPESSNTSESSDWVPKDVYEMGFLDEDGNWRCGYAGCRSGSIFHRACDLRKHYTSHTKVFFCARPECAALGLGFAARKDYERHMRSHQPNIACLDASCNRVFSRMDNMKPLLQDAPTTTKYPVSETLSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPY6</accession>
    <name>A0A7D5UPY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g014780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549045.1">
        <property type="nucleotide sequence ID" value="XM_014693559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPY6"/>
    <dbReference type="GeneID" id="26238489"/>
    <dbReference type="KEGG" id="mbrn:26238489"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="433"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="591" mass="64916" checksum="C7BB214F95F0CCFB" modified="2021-02-10" version="1">MSPVFWPFWRRKPRSQLPDEHTTTTTTTAAANPNIPIGPLDTSAASTTHPPRELELHVRGDAAQAPPPAPPSRFAATTSGSRPAPSLITPERPEHPEHRRPRRRRADPDSPITTPNPFPPSSSPTQTPARDKPASRRLKAPSQQPAYPLASLDRAAEPAAAAVAALSPPQPSVHGQVYKPSLVQSPFRPRTKATTDPAHRLRRLPAARLWNPTNSTPRLPQPRKRRPSSPPIPALPLKHPALDRSLDIRDPVTTGAGDYPLLTLPEQRRSRYSQSTPVSFQLELGETSDHRISLPRSVRASYEGKRSVHRTSTHLEATAEQQVNDQHAQEASVAYLSAKSKGKQKATMAPESEDARRPYSKDLERGPDVMDHRASNISAGEGIGSALSSSNSSIMGDDVQPDAGQEWGPQHPCFPHLNPHVPLDSVEHATTRIIRVKRDWLVAGDLAPTFSNLYPEILDPAGVSEQEFRRVIEKLNGELIPIFDPFTFRNMLDSVLGLVTGWLWDDFGLTAAKSRLHNLEKWIEKWNQEMEKTMASEEGIIPPKLISLRQTGYMTLDIQIPDPEIAPAPSTIGAGESQTALPMEPAPAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ63</accession>
    <name>A0A7D5UQ63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pip_0</name>
        <name evidence="4" type="ORF">G6M90_00g012330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549289.1">
        <property type="nucleotide sequence ID" value="XM_014693803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ63"/>
    <dbReference type="GeneID" id="26238733"/>
    <dbReference type="KEGG" id="mbrn:26238733"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="76"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="52601" checksum="92E29478A636413D" modified="2021-02-10" version="1">MGPAILDIPPAKLLSSQDHLLPGQLKITTFFFQVPLDYENPSASSIQLYARRVVKHESPIFPPDEEDALKNTKPYMIYLEGGPGFGNRAPADHPVTRAALPRGYQVLYIDHRGTGLSTPVSTAMLANVGDADAQAKYLRLMRQDNTVRDCEAVRKLLTAGWPEQKTQWSTFGQSYGGFITLSYLSMHPEGVRESFLTGGLAPVGKTIDQVYDATFRKTTERNEQYFAKFPEDARVLRQIATYIEGQGGRIPLPAGGFLTVQRLLTIGIAFGGHGGFDTVHSTLTTLKASLDQFGFFTRAALAPLESFTPFDTNIIYAILHEAIYCDGPRGPSNWAANRVGRILGGPYSWLNPDFAAAQSTGPLYFSGEMIFPFHFDTYPELTPLRDVAEKLATYTDWPALYDEARLRNNKVPFYAASYVEDMYVEYHLAKDTSDMVKGSKVFETNVMYHNAVRAKADEVMHQLFSLRDDVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR23</accession>
    <name>A0A7D5UR23_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NFX1-type zinc finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Znfx1_0</name>
        <name evidence="6" type="ORF">G6M90_00g000380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985793.1">
        <property type="nucleotide sequence ID" value="XM_066129485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR23"/>
    <dbReference type="GeneID" id="26244401"/>
    <dbReference type="KEGG" id="mbrn:26244401"/>
    <dbReference type="OrthoDB" id="4917429at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="251"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="578"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1150" mass="129950" checksum="85A36ED2D80B3FC0" modified="2021-02-10" version="1">MSILPTVQGLLSEISPSKVTYARAQRMRDSRSYLEDQFWLLHQDLALWTCDEIKSFTNDDPSARRGTCLDNLTVEGPHSSGRHPWSIQFRCLQDFPALQDKNEAERRSLLQEHKAFLRNESSICLLVDGTPRWFGFLTGEEDYLCLSPPVINIRLLETELDKASLILTRAKRISCLLLHTPLFAYEPVLNGLSRMSNIPLEESLLHWTPGKPAPRIDYTLTAEMSGFLARLEEDSSLDLRETLRLSSEVRLDPSQAACFKAGLSQSVALIQGPPGTGKSFIGSLIAKAIIEHSAERILLVCQTHHALDQLLTDCLRLGLAPSKIVRMGSTKKATQTTQSLSLHLARSRQWFSPSQKKEIARHRDAIDSSTSKLRDAFNNITGQKFSKVDIMKHIKTLKDGELPFYDALHPPPRTSKPEHEFYLLDRWLAGKDCGVLKAHGSRFPSVWRLNAAERKEVFSTWEREMMTKRLVMLRMAGNEHDDHVERLNAIHRDRDINIIRRKRIIACTTTAAAKYMLTIQSAAPTVVFVEEAGQILESHILTALGPRTKQLVMIGDHKQLRPRAHHNLCVEKGNGFDLNRSLFERLILAGYPHQVLSQQHRMRPEIAALVRELSHPSLTDAPRTLGREHLRGLQNNVIFVSHSEQEFELGHVLEWRDFESTKSKRNLFEAQMVVKCVQHLTQQGYSTERIAVLTPYLGQLRLLIQEMLLHSDPQLSELDSQDLVRAGLTPPTLVPTGRPHIRVSTIDNFQGDESDIVISSLTRSNSRRDIGFMASRERLNVLLSRARDGLILVGDAETFRESPAKDSPWNQFIDSLVARGHMYDGLPTRCERHKINGAVPRNPEEFEKKCPGGEEYFSTEDLLGPEPREYLKTSSAWKRLQNLIGVQRMKDSMAELVDVLQLGYELELKEEPPVPITLSRLFLGQHGTGKTTVCWLYASILSDLGVIQSSDVVFKHPDDLIGDSVEASELRTEVVLQDARGKVLAIRDAPVLRDHRDDAEKACRIAVIRKLLAAAGDEQENPQCLILMFISGDRALNTFNGLGRTDIARYFPIDAAFSFDRPEDEDLSLLLDLTLRKRRLSATVVAKEAALHRLQGARGPRFGNARAVETLVDMASDRARLRQWSVSRGDERLGDNVMLEEEDFSVHELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR28</accession>
    <name>A0A7D5UR28_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">METTL27_0</name>
        <name evidence="3" type="ORF">G6M90_00g029840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541188.1">
        <property type="nucleotide sequence ID" value="XM_014685702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR28"/>
    <dbReference type="GeneID" id="26245823"/>
    <dbReference type="KEGG" id="mbrn:26245823"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="220" mass="23395" checksum="E80B189BD124CC35" modified="2021-02-10" version="1">MTKFKQSNTAKYLTSIYSVSTPTECASIYDSWSESYDVDVVQGNVEYVAPRATALRAKTEGGNMTGSILDAGCGTGLVGVALAQYGAKNIDGIDLSSGMLNEARKTGVYRDLSIVDMSKQIDKADESYDVITCCGTFTPGHVGPDPGIKELVRLAKKGGVIVATITDVIFDTGGYRAEIERLASDGLITIVATAKEPYRVGSNTLAHMVVLRRSNLAIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URQ0</accession>
    <name>A0A7D5URQ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SDR1</name>
        <name evidence="6" type="ORF">G6M90_00g018590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548681.1">
        <property type="nucleotide sequence ID" value="XM_014693195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URQ0"/>
    <dbReference type="GeneID" id="26238125"/>
    <dbReference type="KEGG" id="mbrn:26238125"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="250" mass="26923" checksum="FE8575C4FF5036BB" modified="2021-02-10" version="1">MSLKGKTAIITGGAKNLGADIAKELAALGANLALHYNSTKSKEDATKFEAVLKQKYPGIKFQFYQADLTTEAAVNKLFDSVKKDFGRIDIVINTVGKVLKKPIQDVTEAEYDEMFAVNSKSAFFILKAGAKNVEDGGKLITIVTALLAAFTGFYTSYAGSKAPVEHFTRGVAKELQPRGISVNAVAPGPMDTPFFYPQESPEAVAFHKSQALGGRLTKTEDIAPIIRFLVTEGGWITGQTLFANGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US21</accession>
    <name>A0A7D5US21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985987.1">
        <property type="nucleotide sequence ID" value="XM_066129610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US21"/>
    <dbReference type="GeneID" id="26239317"/>
    <dbReference type="KEGG" id="mbrn:26239317"/>
    <dbReference type="OrthoDB" id="5014592at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="25510" checksum="89F95964B13D8662" modified="2021-02-10" version="1">MGDSLPPWLVFAHYPTTDWAGIGIGTRVRFAPSPTGFSNAEIHLERARHFNRWSWASSAQAKQSGKYLEQWFRCGEHIRLPDRGMSSVEIEKPLVDRPDEKILYRLLVVDGFTGHTTLAFAEYCIKFNIIIAILPPHSTHLMQPLDVGVSQPLKTAHQKALRKSLAEGNLTFSRIDFLAEFQQVYEAGFTSHNIMSGFEETGLWPAVIRNGRGGTEQFPAQSMSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USE5</accession>
    <name>A0A7D5USE5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g027100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547877.1">
        <property type="nucleotide sequence ID" value="XM_014692391.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26237321"/>
    <dbReference type="KEGG" id="mbrn:26237321"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="475"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="778"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1193"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="841"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1214"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1286" mass="140893" checksum="94810B610C807302" modified="2021-02-10" version="1">MYNRESKIMRKLLGKAAPDSATGDLASITGTTTPIPTSYRPSKSQNAVYVAGAPISCFDVSADRRAVVLGGAHVLKTILLDDLTASSFNFYDGIDVRTAITTRQSTVSRQNVVADQLNIRDVKWHGNSHVYTACASGKVFSYDLTRLGAGDNEPLEYILTQEDSRQMNTLDISPHLKTWLLTGGQDGTARVFDCSNTTPARHGLSFRQRFAPLRCIDPIRKVRWSPANGHEMACCTESGVVMKWDVRQPSRPVLRINAHEKSCSDIAWHPDGIHLISAGMDTKIHTWDLGNTADKRQKPKWTISAPAPVAAVAWRPGLWSASAHARRVAQIAVTYDETSSRRYGTSAVHIWDLARPSMPYKEIERFETSPSALAWQDQDMLWTVGQDGTFNQCDVAFAPKVIDRQSTSAMAFSPRGDVLMFLDERPLSHRPRLPVVHQSDAMHRATYSSSPSNQGLSISRSDSEDDVIGTFLGSRRRIPRKRRPSGRGTIPLSTTPPSGGAPFPDDNKQNMGLEQSINITGVFRSQQAMSFGPIPAAKPVQIYRFLSNTYLETLKRELPYSDGGKPLVERVGVIMEQYAKAAEVANLYRLAQTWRILAYATNLLLKRRAQYHFEVRVGQFQKLQVDDVVKGADKLKASEMYANGEDTPRRPSAQRSSIDGRFHSIRSLLAEEIESTSNVPTPVARPADSATSTATSGHDDAVHQHGKRLSPIVEPESLTIGPAAHGSFGESQSPRKRHDSEPISVGSEQTDDSATSYTEGYDFYDAEVLAKAIDVPMPRRKNSSRGVPYRGRTVRQDSDESFVQMFSISNGTKRSGRMGSSGDAFAKPLNREQSDLERESGTSSADSPAMANTLTGRNDRSPRSNESQEEVFMISQTTKTDDSYPSQPSFTSQDTDGIGLGESLHNSVPDIRTSRSVSPKKKESIQPRHDPRPHVVETDYLPWSNDPPYPYPVNAHNSKASPASISPLNPYSLLLSALDFESKTSALNASAMILLLRPLVPTSVIDSHRASAILRQHHQRLMRMSLFVEAALLRNLCIQGWPDGLPDWGDNYISIFGGAQQGVKVGLFCSSCRKPREVDPAGGRDAVWTCERCRSVMAPCPVCGHREAERPSFIPSETTPSASDVESEMWLSEWWYCLGCAHGGHASCLQLWHGASEPVAAADPSAKYSDGCCPSDGCGHACLPGKYRGETTTARSDELGRAAVDSSRAREGPASRGGSRRSSPGAPYERSVKSDINDVPQSKAVGMAREALNKGGGGILSSSPGRSSGVGDRERRKSVKFARTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USI2</accession>
    <name>A0A7D5USI2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dimethyl-sulfide monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dmoA</name>
        <name evidence="8" type="ORF">G6M90_00g029530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541218.1">
        <property type="nucleotide sequence ID" value="XM_014685732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USI2"/>
    <dbReference type="GeneID" id="26245853"/>
    <dbReference type="KEGG" id="mbrn:26245853"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="39"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="482" mass="53010" checksum="B10066D94A82C0A5" modified="2021-02-10" version="1">MADSDASLASSPKKKLILHAFVESCSGHQSPGLWQHPDDRSSNFNNVSHWVELAKLLEKGKFHGIFIADVLGSYDVYKGPKNPDPAVVSGAQWPVNEPLAVVPAMAAATKNIGFGVTVATTYEQPYHLARRLSTVDHLTGGRLGWNIVTGYLDSAARNLGFTEQPPHDERYAIAEEYVDVTYKLWQASWRDDAVKLDPKTRVYTDPSLVRTINHAGKYFTVPGPHICQPSPQRTPLILQAGTSSAGKAFAAKNAEAIFVAGHSPSTIAKNIADIRQQAKTQYNRDPRSIKFLTLFCPVLGKTQQEAEAKYREYLSHGSEDGALALFGGWTGIDLAKYGDDEELRHVESNAIRSAVDAWSKSTPEVPRWTKHTVANHIKIGGLGATVVGTPDRVADEMERWVAEADVDGFNLAYAILPGSFEDIIELLLPVLRQRGLFWDDYAVEGGTYRENLSGEAGQRIPREDHPASRYHWKSGDQPALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USJ2</accession>
    <name>A0A7D5USJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bouquet formation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bqt4</name>
        <name evidence="7" type="ORF">G6M90_00g018880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548652.2">
        <property type="nucleotide sequence ID" value="XM_014693166.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USJ2"/>
    <dbReference type="GeneID" id="26238096"/>
    <dbReference type="KEGG" id="mbrn:26238096"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="430" mass="47223" checksum="1F8D1C3BD0FEB820" modified="2021-02-10" version="1">MATPSQRSLPTRHNPFLLENVPEYLELVQRRRLGQTKLTPKMVGGDDAESTALGVFDYAHLRAPLPKGIVSGIFKSSPTSYFLMRRSFDGYVSATGMFKATFPYAEASDEEAERRYIKSLPTTSPEETAGNIWIPPEQALALAEEYSIGIWIRALLDPAKIPVSSYSNPDSPPKNISAPPKFDFVKASAKLAPPSTSTLAKSSRSRRSVSPTKGSRRGPASPRKRKIQSKASSTEPTADKAEVNGDSKNGKQEDIVLKTSEFEPAVVLEPRTEDATMKIRVDEVSKDAAGHETKHTVTEVDVPLPVAGEPPSAEEVARMMEAAKEMVQKDREADEKHAEQQKKYDDDKGTDTTTTTVKKGKRKAGDISMSEKDDEKAHSMAEEAKEEQPRAKKVKTEAELRKDRVKNRALFGIGATVAVGALVPWLVNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USW1</accession>
    <name>A0A7D5USW1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type ATPase, C subunit family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g012500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549272.1">
        <property type="nucleotide sequence ID" value="XM_014693786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USW1"/>
    <dbReference type="GeneID" id="26238716"/>
    <dbReference type="KEGG" id="mbrn:26238716"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="53765" checksum="110F718B01F82BF2" modified="2021-02-10" version="1">MALYAQRYMLRGFASRCYITSRRRISTLKVPDQTRFSYFLSPKDGTRDLLTNLSGHAVLENSRGHDAAVVLATPDLTKQLDDQEFISGLVKLLSASASISDFHLLCAVVDNIAPALGDVVPLQGISVLRGNVDSLLPQLWHPNPPREKADKDSVAALTFSVGKSTVTLPLTRTTFHNNRASTLLSNRYSLSEGQPELKDRKEKQWQHVQITLNQPVQSTTDLGLWAPLSPVTRARKITESFGNIVRGIEIGGKSTPASTELEDSVNTMLANRKATGSDQGPMGVWAVITPETSESESLVLADAPNPADTLEGRIVQRKDVETTARYLEQQHQLGSRTYQVLSGGGGWGPKKGLLSLDPQQTHFALSEAEEMERFMKTMDSSGFAPPGAHIQFFVPAMASPEIITCPVTGVVFGVPLGIETSGEAGTAPKGYLVADHFGALSSQGVYLSGRTDADSASCYESKISVPGCRIFVGNPEAKPGGFFNFLGSGSLADAGTIALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USX5</accession>
    <name>A0A7D5USX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maltose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MAL31_0</name>
        <name evidence="11" type="ORF">G6M90_00g005390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542186.1">
        <property type="nucleotide sequence ID" value="XM_014686700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USX5"/>
    <dbReference type="GeneID" id="26245217"/>
    <dbReference type="KEGG" id="mbrn:26245217"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF76">
        <property type="entry name" value="MALTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="62"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="541" mass="59689" checksum="19E45EB5C090D6B2" modified="2021-02-10" version="1">MAAHDPSSTDVKVQGPQHHKHHQDGNYDPKSSLIAEAKSGAIAEQSMSLGTALHLYPKAILWSVLLSSTLIMEGYDLALLGNLYASQPFNRKYGTYNTSTKKYAVSAAWQSGLSNGARAGEIIGLILAGWTVDRWGYKKSMVLFLALMIAFVFVLVFAPSVGVLVAGEVLCGIPWGAFQSITPAYASEVAPVVLRPYLTTFINMCWVIGQFFAAAVNKGSNGRTDEWAYRIPFAVQWVWPVPILAGVLFAPESPWWHMRKNDRASAKASLLRLTSPSHTAFNPDAALALIEHTNEKERQLKEGVSYVDCFKGVDLRRSEIVIGIWLVQTLGGQNLMGYFSYFLTQAGMDPQNSFSLSMGQYALGMVGTAGSWLLMSRVGRRKIHFGGLCCQFALLVIVGCLSFSADNNSVWAIGAMLIIFTFVYDFTVGPVTYSLVSELSSTRLKNKTIVLARAAYNASNIFVNVMTNYQLSSTAWNWGARTAFFWAGSCLLSVVWVFFRLPEPKGRTYAELDELFERGVPARKFAKTHVDPYAGEEKHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT70</accession>
    <name>A0A7D5UT70_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g024830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986130.1">
        <property type="nucleotide sequence ID" value="XM_066129944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT70"/>
    <dbReference type="GeneID" id="26237542"/>
    <dbReference type="KEGG" id="mbrn:26237542"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="945" mass="106614" checksum="D8289B3C053B81F0" modified="2021-02-10" version="1">MDWEWGFENGNNSSTKLFEDLANVPLPRFFQSIYQPPGQIPGGLFVDGVGDIAMPLDETQARQMIEKARPLPPSETSYRNTNAPIRGNWVLDANKFSLYHPDWPSFLQALCDQASRNLGINTRVTAKPLQMHIYEAGNVPSITEHSPLKDERPGMFGLMLLCLPSGHEGGGITMTCPDRDIPWLRTSECQSYACFYPQSLCEVAKVCSGFLWFLVFDIGFDPPVPLPLKAAIQQPMVYKLRGSLERWLSDMKKDSDCMCAYHLLHYTYTKANFSLQGLKMQDLDKVQALKALSREFPIEILLVELEHEVRSLYFNKHKDDDGTEDDDGTEDDDGDVEEQVDFEEDLYYCGDDPELEIVAEEYHTQVKALVDLDGNLVLKGTAPNGVNLRGGFVDPILQLKKIKRDTSDGYVVSLRQGKAIAIVPHGSLIGFIKDESDFDAVRETLDSMIRYFGGLCVHQQASESLGRQVLRLCDYAWEKKTKLIPFPDRNPILTGDAMFLALQIAVGLEEFGFLTRVAEEHDGDLPPDFFIWLRQWLRFGENGAKIRFKAIVNGISVAVSNYKFFIDAFKAIGNLAPLSKNNFPRYGSSEVELMEWARKMLCECIDASASMALGNEDGQAIVRSALYFRDPLEFISQTVAPRLEKRNDAIAFFLTFRHEMLHNDPFAKEISLHLHQTRSLIQVMDFKHARKTSVTEAYTDLQAKRLQVRAVIIPQLLAGFFSDVVHISTETDNLMALLISKITAGAANIKSTEFPTLWLPFLHSIIPVLLSRGIPLHSVHCQTLFSVILSAFVKIYVGKKPLKNATLALSHVPCGCSKCGRLNTFLRSPTQRVGSFSKNAAVSDHLRAQLESLWDAGDIAYEEEELDFNFGTKFTVTKTDHARILCEWNSRRDQARFQLSQFDPRQLQLLLGSHYSAIFNVLTQLPGCDDEMLWVPLDAKLTLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTK9</accession>
    <name>A0A7D5UTK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g000020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986097.1">
        <property type="nucleotide sequence ID" value="XM_066129471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTK9"/>
    <dbReference type="GeneID" id="90967383"/>
    <dbReference type="KEGG" id="mbrn:90967383"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42435" checksum="EE9AE1FC0B6173B6" modified="2021-02-10" version="1">MRGNGFFIEVPGQTNDIILTAGHNLVDSHGMSSTDLMAWWQDGGEWISIATENVRVSKAYLARPTEQSATDDFGIIILKSENVKQRRQAFGFSIRLGEDDRIDGQCNISSYSAKSFLMDGPTQSTGRFVNPIIAENQLEYLVGTSAGMSGSVVWVGYNGSPIAVAIHNYGPRIKDPRYGSRGSRINLKMMRQIFEWTGVYRRAVNVVAAPSMAQSEPKKPLRLMYSRELKFMQVQVHDPKDRNPETTFEVLPVYSRARTAPTGYPRSDHGFACRQDENESQTNDMAWISWDVEAREAYPVTRLSLAQLARLNNLAGDSSTISLIVNIKEWIVVVRPDKVSDETDLEYNGSVFPGLDFASTIDQQLPTTYKKFKFITTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU05</accession>
    <name>A0A7D5UU05_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lea domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547762.1">
        <property type="nucleotide sequence ID" value="XM_014692276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU05"/>
    <dbReference type="GeneID" id="26240325"/>
    <dbReference type="KEGG" id="mbrn:26240325"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12719" checksum="E4B19EA19C2ECD2B" modified="2021-02-10" version="1">MAFLAERAVRSAVPMCRTIMVQAPRAFSTSVAMRKNPTETVKDGLKTVDRTVTDNVVLPGLEAAATAGSKIKQGAETVAKGTKGKAAEMEGKAEELKGKAKGAAAEAEGKAKGTVEKMKNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUD7</accession>
    <name>A0A7D5UUD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g048460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544961.2">
        <property type="nucleotide sequence ID" value="XM_014689475.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUD7"/>
    <dbReference type="GeneID" id="26242302"/>
    <dbReference type="KEGG" id="mbrn:26242302"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="33052" checksum="CB6800465C7569E6" modified="2021-02-10" version="1">MIRFENRTFGDLIVLDHIPEDDMTANTIKTLELYKWLINHGSKYEFVTKLDTDVWINAPAFWEKYLVPRLSNKTGHLTAAVNRTVIGQLYFSDSGYNTFAHGSMYTLTWDMVQLLVSLQESFNVFTGEDAAVGILMHKGSQTANFVNFRGDEKFDYDDSDSREHDFAWARAGTHPNAISHAVYGSNVIAVHKLKDERLWRKVANCFSQRGINPMPPLQRPERRLSFRTRWNDWMHSIGLSRPYVSMMETIPKALLTHDIDHWVCDNIWNLGASQEGFNPYVADTNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUG6</accession>
    <name>A0A7D5UUG6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g036220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547016.1">
        <property type="nucleotide sequence ID" value="XM_014691530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUG6"/>
    <dbReference type="GeneID" id="26239579"/>
    <dbReference type="KEGG" id="mbrn:26239579"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00838">
        <property type="entry name" value="MPP_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="302"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="547"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="707" mass="74754" checksum="FD279E87D6857C78" modified="2021-02-10" version="1">MAARFTTARTAPLGARTSAPRTLTNGFQSRPYNSQGYLQNGGSSLPPGAAPLLPNQGRVIQTGPIRVLCIADVRGNLRSLNELAKQARADHIIHTGDFGFYDDTSLERIAEKTLKHVAQYSPLIPDPVKKAIQQGGNGPVKTRFPPSDLPLSELPLLLSGEVKLDVPVYTVWGACEDVRVLEKFRSSEYKVPNLHIIDEARSMLLEIGGVKLRLLGLGGAVVMHKLFDNGEGRTTIAGGQGTMWTTLLQMGELVDTAHRVYDPTETRIFITHASPAREGILNQLSVALKADFSVSAGLHFRYGSSYNEFSVNPTLDHYRGKLAASKASFNDVWETVKGEVEPAIAQNEAQQNLLKNALQIVEKMPTTAAGGNPFGGPVTGQAALGQVDESAFKNMWNFNLADAAFGYLVLEIQDGRIGTEMRAQGFNFSHRGAKQQPGAAPPTTAASAPPPSVSTAAPTVSTPAPPVAAAQPAAPASRQPSSTQQPRSASATTPAPGPAKPATPQPSQTSNKSGGSKDNEKTSAAPNGSANGPEPTSSPAPKTLASDIIGLFIMNVSSEDQCRDLFDEADKGKIVKIEKWGNQNKVVQFKTTEDRDAAMARLPEEIKTRTQEDRTRPLVKIFQHREGKTFSNRGGAGTWGANARGGATASGYRSAGGNSDSESNRRGGRGGRGGRGSDRGRGGRGRGGMKGEGGASSPAATPSTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUN7</accession>
    <name>A0A7D5UUN7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g048840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544995.1">
        <property type="nucleotide sequence ID" value="XM_014689509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUN7"/>
    <dbReference type="GeneID" id="26242336"/>
    <dbReference type="KEGG" id="mbrn:26242336"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="109"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="35887" checksum="D0C9D8AF4D80B449" modified="2021-02-10" version="1">MRRLSSARDKLFRSSSRTSSQSKKSESSRGLSSSTSGPSSYPGPNNFSDAAPPAYTPAYQPAPAPVFLSPPSHAPVPVPSPVPAPAPAPAGVYGGVSDGDRYANLANFDTILLIDDSGSMAGSLWREAQDALKSIAEIVTMYDEDGIDMYFLNHKSSQTPSDRYKAKGGYYNVARKDVIETIFGNVSPYGATYTGRRLEQILLPYMRKLASANDVDDVKPINLIVITDGAPSDNPEQAILQVAKALDQQAAPSYQVGIQFFQIGSDSSATSALQQLDDGLGRYGVRDIVDTVSCQWEDAGRHRAKRLTGDAILKVVLGAVDKRLDEHRLTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUV0</accession>
    <name>A0A7D5UUV0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g046960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544819.1">
        <property type="nucleotide sequence ID" value="XM_014689333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUV0"/>
    <dbReference type="GeneID" id="26242160"/>
    <dbReference type="KEGG" id="mbrn:26242160"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="702" mass="76504" checksum="301F0AB19E00039B" modified="2021-02-10" version="1">MPRPKVLPSQRRRAAEACNFCRDAKKKCSGTAPCSYCLRRGVGSQCIIALRPRGSRNQAVSDGPRLPCDTQPHRVGLEAQSGMLDLETGGPRCTPSAQLPILNVDGKGRRKGPDTSSFRPLSPSDSRPSLEGPESPERRRHGASDASSVSGNPHSRMLFNLRGERVYIGGAASLSFLQLVRSIVADQIGPSQFSHNEKSDTMLEKESPSSMRNLPPSTLPELDVETKLLYSQCYRAVTEGFIDIFAPTEIEEYFMLADDSSFSPQKRAALGMVISIGAQCKSAASARDIGQGYFRQAQSQAFQGLLEDPDIDVVRSFLLMAFYLLGECRRNAAFMYLGIATRAAVALGLHSQESYQDLNDLEDNKRIRIWLSLRIVDMLVNAILGRPAATAGLSSDINTILDHASETEQTDEMARLIASHQIVSIINGIVDILYERKEISTSVVENLLNEIESWSRSLPSCLRSPAKGGALSGSNYTKGAIGSVHVSCLYYFAVTLVTRPILISTLTAPPASGGLVQSQLASACLDAAVYLIQTCMDARKVDILYGNMCIMKALVFAAGLVLGFEIFAKRSIEFDIDAAFAGARDILNFLATQSPQAGHYYEILTLLSNAISKQRQNVASTGRSRYVSKIFTLQEAKEPVSDSPRDDQGRLTPLAGGLIPPFAENAGNWLSDNRTPADPGQEVFLGWDSLDISQWDNFPFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUW1</accession>
    <name>A0A7D5UUW1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g048320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544947.1">
        <property type="nucleotide sequence ID" value="XM_014689461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUW1"/>
    <dbReference type="GeneID" id="26242288"/>
    <dbReference type="KEGG" id="mbrn:26242288"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="532" mass="59055" checksum="1CB20D6A1D72F47D" modified="2021-02-10" version="1">MALPSDDSNPGISHLHASESDALLGLRTMAELSQDPSRLEPAPDAAVARRVLKKIDRAIIPVLFVTYMLNFMDKIILSSAAVFGLRDDNHLKGQEYSWVSSIFYFGYLFWEYPTTILIARLPTGKYLTANTVFWGVVVTLTAACKNFGGLMAVRFLLGVAEATITPGFMFLTSTWYTRDEMPTRVGIWFAGNSVGGLVSSLLAFGIGHIEDNVHPWRWMYIILGLGTFLWAIPMFFLLPDNISKARFLTPDERQIAKNRVIVAGTGSTENSSWRWDQVVECLIDPKSWLIFFISLLTQIPNGGTQGFSNIIIQSFHFTNLQSTLINIPYSLITAAVIAGTGHLSGRFRKLNCLLIVTVVMPCVIGAAIIYRRTAVSHGVQLFAYFLLSTGPAAMPLAMSLVQSNFRGVSKKMTMTAMQFIAYCTGNIIGPQLFRQTEAPSYESAFQAIMICYALAMTLAVSLRFYLQWMNARRTKKEGFDGSAGAAGAVADGKMPMQLTSRDVAEVVTEIQLQPEDYEDVTDWKMAGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWR1</accession>
    <name>A0A7D5UWR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GNA1_0</name>
        <name evidence="3" type="ORF">G6M90_00g054280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540976.1">
        <property type="nucleotide sequence ID" value="XM_014685490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWR1"/>
    <dbReference type="GeneID" id="26246282"/>
    <dbReference type="KEGG" id="mbrn:26246282"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="170" mass="18738" checksum="85EDDB97E8DB6CF5" modified="2021-02-10" version="1">MPLFPASLISPEVASSLPEGFTIRPLEKGDYAKGFLACLHDLTWTGDQTEHEFNERYDEMDTHGKGPYYYVVIEHAGRIVGTGAVVVEKKFIWNRASVGHVEEICIAKAYQAKGLGLKMINALDSVARNVGCTKSLLNCDAAKSGFYRKCGYASAGMEMQHPFKSDEPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWS1</accession>
    <name>A0A7D5UWS1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Positive regulator of purine utilization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">uaY_2</name>
        <name evidence="10" type="ORF">G6M90_00g051590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539844.1">
        <property type="nucleotide sequence ID" value="XM_014684358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWS1"/>
    <dbReference type="GeneID" id="26247399"/>
    <dbReference type="KEGG" id="mbrn:26247399"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="875" mass="96584" checksum="C7C399928128FDB9" modified="2021-02-10" version="1">MTSSRGADSSGSPCSRKRPREDSPDDCLPDDDARDGNDTSQGVADGRLGSVAGQSTNFRNVSACSRCRSRKNRCDQRLPRCTSCAKVGAACVGYDALTKRELPRSYVFYLENRVERLEKLLVSHGIAFPPADDLDMSARGEANGDEPGPSSPGRPAIQDSLDFFLGNRRKSFASSDNKGNSPKAMSRDSMGSALLNPQTAATFMAVALHTTQTSNLDNEKMLKYHMEDPQGFEATRCAMPDKALALKLVRAYFHRANPQIPILERACFTKIFDKAYSGQGGGLRPREQYLLNMVFAIGCSHGFINEQDKDKAIGAPCVGSNTSKANLSPEEYYSRACMYFDQCIVREKSLEVLQAVLLLASFSLLRPVLPGAWYITGIAIRMAIDLGLHCDTDDDAPDRVPSPMEHSRPGAANGDECAETEETAQRDIREVRRRLWWCTYSLDRLVSISAGRPFGISDNDVCTPLPSLDEDDTPKDGESTNSPESHDLPQSYKYLTHHFIKLRLLQSDIYAAGRTCKGHASKITMRQEETASESPFEADSDPESKWQWLEGMEKRALEWKASAPTTHVTGVLFPKAIFEFYYWQTIVLLYQRDAKIPALMQEVQSVLDKLHVSAAPASEADVFTTRRYIKMAQAGQRVLRMYRQRHLAGCIKYTYSSALYLFSVAISYLHAVAQSSAVRARFTPDDVDFTILAARSIFADMADTCPDATMWTEALERTAKATTRITRLYDDLDQPSRPADWDEDGGGVLSDHGVTSAASDAHVGREDGAHAWQTLGGYEDSRPRGSPIHWDFADETTSFRLGGDDAVSALDMAVPPFGSLPAQALADMESRRGDIESGDLFDLETIWQLDNLATEAPHMCRVLNVGASVVETGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX47</accession>
    <name>A0A7D5UX47_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent monooxygenase OpS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">OpS4_1</name>
        <name evidence="7" type="ORF">G6M90_00g063720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542513.1">
        <property type="nucleotide sequence ID" value="XM_014687027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX47"/>
    <dbReference type="GeneID" id="26244462"/>
    <dbReference type="KEGG" id="mbrn:26244462"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="50511" checksum="3727BECCBDB9A715" modified="2021-02-10" version="1">MKVIIVGAGIAGLSLAISLTRHNHQVVLVESAPQLAELGAGVQLTPQAIKYLFKWGLKDDLLAESIVPDCMYIRHYQDGRLLGTIPVDQMAARYGAPYIVVHRAVLHSILHKHAADGGAEIRTGARVVTYDFAAGAVELHTGERLEADIVVAADGINSLARQQLLGASDPGSRPTGWAAFRMSVEMGRVRDDPVLAHVTGLESGSSNFWIAPHRSCMTYLVKGGTMLNIVLSHRDDVDTRGFSLEQYKQTVDEQFRNFDTPGGASVRRLLDLSGPEISNYPVYEVPPLPKWVHSSGRFTLMGDAAHAMAFYMSMGVSLAVEDATALATALNFVEAKANSKAHGSAPTLASCAGKEILRKVMHGFQKVRMRRVLAVQRASLYAGDTLHVEDGDKRVALYEALRQSDKAFLQPPMDPNQIVEHTIQIVPGEPERCGLGGISDKATRDWCYDFDADGDVLSAIEMADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXI9</accession>
    <name>A0A7D5UXI9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g066010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986697.1">
        <property type="nucleotide sequence ID" value="XM_066130813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXI9"/>
    <dbReference type="GeneID" id="26246980"/>
    <dbReference type="KEGG" id="mbrn:26246980"/>
    <dbReference type="OrthoDB" id="3231004at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="544" mass="60249" checksum="9A09E4E03AA40759" modified="2021-02-10" version="1">MRYTHLVAALTAAHITAAKPVAKLPGEDGINDIDNNIPDSTGPPSGGSNGQPLKNPHNNLGAGASTVPYSDGLTLGQGYNTYLQEGCMNGAVDVTGPTNAPGQVQIEYQATQITEYSQIIKELGISASLGIQYLDDSVEVSGKMLDKSTFENSALTYIVRADVKRQPSSDLKYKFMWNEAKNPTERYYFVEGGALFAQVSIQSTESSKKHELEAKAKVAFGMFGVGVTVSTEMKQASEFLSKNSKVISEMFWVGAPPKDTKSGVLGEIKALQSGDASLLDIKSISDKFIAEAGEHHALVERYDQVFNFKDEFKPLDYSDAIEQTWAVFNDYADYDSMQRMLKTIKLPESLQQKQVELRNAIIKAKDGVKTWITNVSKDPSKAASKPSYQSPDAFLGTVMDAFSTTYIVQNIEYDWTKPEYKDHPKNSTLIDDKLRTDIGKTTPVFNIQGVPFPGVTGTSKLTFGHQDGEPWWNIIADGTLPTNYKEQSHVWLLTKKTPTYSQPIYVYEVLDKPNYWWNRIDVNKALPSSPTNIGLNLRFFTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYJ6</accession>
    <name>A0A7D5UYJ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540915.2">
        <property type="nucleotide sequence ID" value="XM_014685429.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYJ6"/>
    <dbReference type="GeneID" id="26246221"/>
    <dbReference type="KEGG" id="mbrn:26246221"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028889438" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="207" mass="22996" checksum="9CE0EDD464F90F01" modified="2021-02-10" version="1">MRVLELFLAASALCTSVFSAALDDFESRPVFIPEWEVEVTPGGDKVRLNGTIQEVHQELLSLNPNWDKDFGLGDKVEAPSDETHGQLAKRTDFSNSKYFCGGRWEYCNGGAIAEGRAYLYRVPGRPTNGAGPGACGRVSCSYNAAIWWCNDEKTPKTLNSFGSIADGVYELEKHCRKYFSWNPSGVSIAGQIFHETNWNVIVRKDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYL4</accession>
    <name>A0A7D5UYL4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g074910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987014.1">
        <property type="nucleotide sequence ID" value="XM_066131023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYL4"/>
    <dbReference type="GeneID" id="90967962"/>
    <dbReference type="KEGG" id="mbrn:90967962"/>
    <dbReference type="OrthoDB" id="4941283at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="39263" checksum="F20350D3AF71B07A" modified="2021-02-10" version="1">MYKERGGGMRMKAETNQISQVIYAEDGMLRAAERSLIYRVDEDEGLSALQPHCPTANCRWPIFSSLAVCVSMGNVTEYLTPVDYYVILPGEFGRDHGGINITSPDTTEPLYKWNNSDIMPLSLARAFFLYAFPTNETDSMAFEAVEVVWHYCVHTYNISVTNNVAKTELLASELTVSQRGEKNTSFTLLAKNGHHEFNLSNFKMIYGFGRRLQTTIRGYWSISSPELRTVNEFTMRANQVNGTVEGDALEPEIFITVRWPWISFLAAQIVLTIVFIWAVAASTSNLEVPVIKGSNAAELFAIRKSDMETTTIGTVDGKQAGIDQKIDKKTLGILVRDYDTWHLEIHSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYV1</accession>
    <name>A0A7D5UYV1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g070410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540637.1">
        <property type="nucleotide sequence ID" value="XM_014685151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYV1"/>
    <dbReference type="GeneID" id="26246510"/>
    <dbReference type="KEGG" id="mbrn:26246510"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028824601" description="Peptidase A1 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="87"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="44069" checksum="7787F16C4700FECB" modified="2021-02-10" version="1">MKTALQTSALLAAINTALAAPASVGETFSVKAKYNQDFKPDTTVELVRTALRYGKLASRDVARILERRQDTNGTVVASPPYKFDREYLAEIEVGTPPQKLLLDFDTGSSDLWVFSTETPSAQSTGHTSWNVTASSTAKKLDKYTWSIAYGDKSTSSGDVYTDIVRIGGAEIQNQAVESALQVSQQFTLDTASSGLLGLAYDKGNTVSPTKQKTWFSNILPRLKEPLFTVRLRHQADGSYNFGYIDKAQYTGDITYTPAFTDDLGHRLFKASGYQVGSGSFEKLSITGTADTGSTAVYLPNSVSDAYWSGVKGVTTQGGFLDSKAYNFPCDAKLPDFTFGIEDAKFTIPGEFINYAPTAEGSTICQGGILGIGTIPEWLGGISIFGDVALKASFVVYDDGKNRLGWAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYV3</accession>
    <name>A0A7D5UYV3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rhlG_1</name>
        <name evidence="7" type="ORF">G6M90_00g076230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987065.1">
        <property type="nucleotide sequence ID" value="XM_066131053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYV3"/>
    <dbReference type="GeneID" id="26241511"/>
    <dbReference type="KEGG" id="mbrn:26241511"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF17">
        <property type="entry name" value="RHAMNOLIPIDS BIOSYNTHESIS 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="27713" checksum="9C780D8B12161EC0" modified="2021-02-10" version="1">MDINTLFGVQGKVVLITGGAKGIGRMIATGFVTNGAKVYITGRDAPACHAAVADLAPLARLSGSIHALPANLQNLDECQALAASLARLEPGGLHVLVNNAGATWGADIDSHPDAAWTKLLTLNLQRAFTLTQLCLPLLERAGSQDDPARVIHVGSIDGVRVPSLANYAYSASKAGLHHLSRHLARDLGFRNVTSNVLACGPFRTKMMKATLDAAEDVLKENIPLRRIGRDEDVAGSAVFLASKAGAYLNGALIRVDGGASLVAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYZ1</accession>
    <name>A0A7D5UYZ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rrp43</name>
        <name evidence="13" type="ORF">G6M90_00g061100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542758.1">
        <property type="nucleotide sequence ID" value="XM_014687272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYZ1"/>
    <dbReference type="GeneID" id="26244707"/>
    <dbReference type="KEGG" id="mbrn:26244707"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="44"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="12">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="339" mass="37577" checksum="86D787EFE7147AD2" modified="2021-02-10" version="1">MAPDAGLSRATFAKLSPHPYLLANLEPSDDHVAPARSNGRAPEEVRPTTVNLSSLSHPHGSSLVRMGDTTVICGVRGETILAQHIPNYRASNRETELRDYDLLVPNIELATGSSPQFLPGGPPTTLAQTLSTRIYSLLHDSKLLQAEDLRIWHTWPSERMVADDDDEMDEDEEDVDKQSGEEYVAAYWVLYIDIFFISFDGNPFDAAWAATLAALRDTKLPRGRYDPDRDMVLCTKKDPKPLTITGMPVACTAAVFTGKETDRPTDGRFWLLVDPDRLEESLCDENITLVVDCQEEAMRILSISKHGGVVLSPKLLRSKSLMSWANQRWKGVTAAITGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYZ5</accession>
    <name>A0A7D5UYZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g079160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYZ5"/>
    <dbReference type="GeneID" id="90968006"/>
    <dbReference type="KEGG" id="mbrn:90968006"/>
    <dbReference type="OrthoDB" id="4933568at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="259"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="690" mass="75586" checksum="EE8BC708A3416CF4" modified="2021-02-10" version="1">MSEPTRSSPPVMHELQSMYHAGIEALPPHLCQMCADMTGSARGLSALISSEGYHHSTVPRVRQAAEGGCMFCSTILDMLLTGHLYSRTAGQAAKRLELDDTVRAFITGKVSQRAQYDNPGLRAPVMLLEAIVVNWVYQGQVCDFHVLHKKVGFYMDRPVVFGAFTNAAEPVQICLVEAAGNPVILSFKPQPLSISAVGDDLVEGYMRLRKECAAEHASTCPPDVEHALPLRVIDVECPGTPMNIGLVVNDASAPRHGRYAALSYCWGKPPHVFKTTTSVMQDGFLLDWSTAPSTIVDAITITRRLGLRYLWVDAVCILQDDEDDKTSQIKDMARIYKNSAVTIVAASASGVNQGFIKDRSVKSIAFPVNAIDATSHNGLRVGTLWVHANTPDEPEEAIDSRGWTLQESLLSPRILYFGSKDIIWKCQAKPFQPVVGWHNLYKAEGMKRLPSTIFGLALPGTQSPLGHWPHIMSEYSRRKLSLDVDNFRAIGGIAEELQKASGDTYIAGLWKNDMAKSLAWFRTDRIVPKPANDDPLKRPTWSWLTTLFPVGQIGIEADASGNETVQVLSWSVELADKTAPFGHVIGGALELSGQVIRASDIPPAVISSMTVMLDAGVCDEDDEQAGRFVGDEYYYMLLGSCGEGKDRIIMLLRELEDGTVVRCGIANLTANTALGIWETGKVRRTKVTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ41</accession>
    <name>A0A7D5UZ41_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g055500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544145.1">
        <property type="nucleotide sequence ID" value="XM_014688659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ41"/>
    <dbReference type="GeneID" id="26242557"/>
    <dbReference type="KEGG" id="mbrn:26242557"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="89"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="35911" checksum="1FF310A79E036BD2" modified="2021-02-10" version="1">MSDGKLYRKYFDHPLEDDGHCPFTLLAAKVPDMPAMYGEGRKHALQRLRSEIERQLGNHTTYPKKPEILHPVNEWIVPFERNFRFTDRESELAELESRLFANNQSTRIAVYGLGGVGKTQLVLELLYRIRDKDKSCSAIWIQATSMESLDQGYLSVARQLGIKDSGAKEVDIKKLVQDSLNDDSAGQWILVFDNADDIHMWIDRTGSESQQTNCLLDYVPRSKAGRVIFTTRDRKVGVKLAQQNVMEVPKMTESTAMRMFHDCLIDKKLLDTTPGDAKAMLAWLTHLPLAIAQAAAYINENGSTLTEYLALSTPILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ94</accession>
    <name>A0A7D5UZ94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium permeable stress-gated cation channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g069030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539991.1">
        <property type="nucleotide sequence ID" value="XM_014684505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ94"/>
    <dbReference type="GeneID" id="26247211"/>
    <dbReference type="KEGG" id="mbrn:26247211"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="44"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="221"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="401"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="881"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="955"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116510" checksum="4431EC52ED271993" modified="2021-02-10" version="1">MALRPTALGALLPRDGGDQKDAGQELIDLLKNPFVADKLATASVYSALATSLGVTAFIAICFSFIRPYHQAIYAPKSKHADEKHAPPPIGKEPWAWITPLLNTKEVTLMNQIGMDATIFLRFIRMCRNMFLILALIGVGILVPVNLTNFKDFSTSSQPDTTEWMLRITPRNVFGSPHWALVVVGYLFNIVVMSFLWWNYRKILHLRRKYFESEEYQCSLHARTLMLFDIPRQGCSDEGIARIIDSVVPNSSFARTVVARNVKDLPELIEEHEKTVRKLEKVLAKYLKDPQNLPAARPTCKASKKDRSFDTYPSGQRLDAIDYLTQRIRDLEIEIKEVRVSVDRRSTQPYGFASYSEIAEAHSIAYACRKKKPHGATVRLAPRPTDVIWHNMPLSSATRSRRRWINNLWIAVLTMLWVAPNAMIAIFLVNLSNLGKVWKGFQTSLEAHTDIWGVVQGIASPALTSLVYLVLPMIFRRLSSKAGDQTKTGRERHVLGKLYAFFVFNNLVVFSFFGVLWSFIAGVIMATEGQNGSKKDAWSAILDGNLAQNIVISFCNNSIFWVTYLLQRQLGAAVDLAQIWPLIVAFFQKKFSSPTPRELIELTAPPPFEYANYYTYFLFYSTVTLCFGTIQPLCLLATAMYFSIDCYLKKYLILYRFVTKTESGGLFWRVVFNRMILGAILANGVVLLTTWARGDGTHMQFYAVCPLPFMMIAFKIYCSKAFDDKMRYYNTQYSAQHPEAGMQGDSRSRSDKLASRFGHPALYKPLITPMVHQKAQNLLPSVYRGRLTDGRDNDGADLATVSGYSDVYALDSMKGGKPGKTANAVPGFEYVSDAQMDFQYYKNRAEFVDEHGGGEMYGKGSDIMRMGTPGSLDDVGSIRSVSRPASPMMSGVGGPGQPRRVMTNMSKSDTGYPSYRPSNAAYGPPSDPVSRGGTPLYAHDNGSSSGLVRNAAAMAAPPGFNSREGSMERGRMTPPRVHSPVPQRVGSPQVSRGPAAGPSIGAMGGGPQGYSDLQQQDEVDPYADPMQYNYFRGGSGNKHARQPGEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZB3</accession>
    <name>A0A7D5UZB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g077270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545374.1">
        <property type="nucleotide sequence ID" value="XM_014689888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZB3"/>
    <dbReference type="GeneID" id="26241407"/>
    <dbReference type="KEGG" id="mbrn:26241407"/>
    <dbReference type="OrthoDB" id="3938544at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="127" mass="14591" checksum="E1370B3085961EEB" modified="2021-02-10" version="1">MDDDEDNGILNIEISDDEVDVTKKKADRTGQSEADFQAVKREYRVRVENGEIYKHVTLPLQPGTNKMRTQELIHAVEELYFFRRYQEGADLVKRALENGGAETLDNDSRHLLESYEKKCSQKIAKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZM8</accession>
    <name>A0A7D5UZM8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Swim zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g060710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986799.1">
        <property type="nucleotide sequence ID" value="XM_066130703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZM8"/>
    <dbReference type="GeneID" id="26243052"/>
    <dbReference type="KEGG" id="mbrn:26243052"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36729" checksum="1433EC78B76D986F" modified="2021-02-10" version="1">MRHYNFGVEIESIGKPYGGGESFTNVDWYRQLAQKLQNRGIEAVHDDCSRYSKHPEYYGGKWFVTRDGSLKRPRPYVCMEVVSPRLDTTLHLTRILSDFWEAMRVHFNPQKDQSCGGHVHVTPVSRKNKFKLRTLKQIAFATIAYEDFMWSMLPPARRENQYCKLNSQSSGSGVCETLAWGKSTSSLKQVASEIKALRSETDIYMYMQGNRYVLWNFQNIFPHPKTGRCTGTVEFRGGNQFLGTKGTLAWVAFVLGFITLATKENLIKRFTEYIPPSDPRYVKRLEEWWVRIRKAARKSKLSRHLPDDYKRMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZP6</accession>
    <name>A0A7D5UZP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g071110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545947.1">
        <property type="nucleotide sequence ID" value="XM_014690461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZP6"/>
    <dbReference type="GeneID" id="26241980"/>
    <dbReference type="KEGG" id="mbrn:26241980"/>
    <dbReference type="OrthoDB" id="5386595at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50755" checksum="E4F4DEF2AACEA09A" modified="2021-02-10" version="1">MAPQVSNLVALRADYTKAQDALVHLQMEFDELSRQIEPDLDPDQEQPEPDREASLQLAILGIELASRQKSTIQLEQNIVIIKREAGVLQPEEAKQRFQELSQRFFRAGDELWRYQKKKRRLDPRPARLLDPRDDGLPECLFALYKRPEGQIQRRRAHSKSRGYIDHPRPNTWRAGALAYYHANGIDYGKGKDAVWCHISGAWHSATCVKTVRIVPPLPDAGCIGEMLFGPRAQSTERPGNALFMRSYLKDWFDNDDIVIIPVNATERPITRWRIGVITDDIRRELCWSAPEGLGQDINGKELKFLGDKRPVARFLYFRFVMALARIKDVKRAGWQDVWARFYTQRPFPTPGDYMRKAMIRALATHFEGADMKVVESWVADHGFESPWKMTDDEATEAARRVHVAMEAVTLRRLEERKYYEDSEEFTDSDSSEDLEWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0C4</accession>
    <name>A0A7D5V0C4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g078680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545241.1">
        <property type="nucleotide sequence ID" value="XM_014689755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0C4"/>
    <dbReference type="GeneID" id="26241274"/>
    <dbReference type="KEGG" id="mbrn:26241274"/>
    <dbReference type="OrthoDB" id="3800738at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="330" mass="37780" checksum="61CED6CFFC36F026" modified="2021-02-10" version="1">MERVLSLPELLENILLHLDMTTLLVSVQRVSKAWNKTIACSPALQRKLFFRSITAEQLPVFREQLMGEVEMAGSDYEYLGPALTKLVLNPLLVKKFGFCFFDTGPAFGYHRGADCFYMLPWSPNRRELITWNRRNSTPLLQVGPPKQLDEASSQLGETRRARFTTRGASWRRMVVSQPAPPGIGYLTQELTQELQLPNERIGEAFIPAVTPGEVQMGQLYDMVQYHAGHHKSELADFRVIWELPQTFLTQSLREPMRQLLGQTTLLVLFAFSYLASYTEPENVVDFDSAFRCEEFLLPDFVVEKSLRFMRGEPDWKGMISPSHKGPPIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0W2</accession>
    <name>A0A7D5V0W2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial metalloendopeptidase OMA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">oma1</name>
        <name evidence="9" type="ORF">G6M90_00g075030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987258.1">
        <property type="nucleotide sequence ID" value="XM_066131035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0W2"/>
    <dbReference type="GeneID" id="90967974"/>
    <dbReference type="KEGG" id="mbrn:90967974"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="145"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="366" mass="40796" checksum="0141307FF28CFAC5" modified="2021-02-10" version="1">MLPSRLVRPSRRIARSAETTAISVTSRPAVGPRFLSQSRLQRSRDPYQRLRNARPLVPDILARRLTSAGRSRNSQAVVVVAVIGAIAFYFYNSQTVPVTGRRRFNFLSDKLVEQAHSRAAEAVILSVEEQGGHFLSDWDPRCMLVKRVMKRLIPVSGLPELDWEIRVIADNRTANAFVLPGGKVFVHSGILNVCRNEDALAAVLGHEIAHNTASHVAERLSAAWVGNLTAGSLFFLAGAVPGLALFGIWTLAGGFFLQDLLYYLPMGRKQESEADYIGLMMMAEACYDPRQAVGFWQRMEMIQKTGGQEVPEMLSTHPSNENRINKIKEWLPIAMEKRQESDCSGTSAFADRFRIALRRGIPVHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Y5</accession>
    <name>A0A7D5V0Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g078070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545298.2">
        <property type="nucleotide sequence ID" value="XM_014689812.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Y5"/>
    <dbReference type="GeneID" id="26241331"/>
    <dbReference type="KEGG" id="mbrn:26241331"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="134"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="25229" checksum="65FF77AD2CADA09E" modified="2021-02-10" version="1">MTLDPSLLNPKDIALFQLAPAWSFDEAGPDWAPFDTSPPMPVKDTPQVAPLLDQSSKSGTGPCAGTLPGDGSGTKSSSPHGQDQLQKRNDTLSNPTRSRQTRPRKATASLPKRQRREQRTETKSGNVNRDHEATTHREGSLERNRIAACKCRKRKKRWVNDLEKRNSWLEKRHKDLGIEYFHLLQEISELKTLIISHASCHDANIDTWLNNEASNDVYVKGVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V186</accession>
    <name>A0A7D5V186_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GUB</name>
        <name evidence="3" type="ORF">G6M90_00g088250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542290.1">
        <property type="nucleotide sequence ID" value="XM_014686804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V186"/>
    <dbReference type="GeneID" id="26244804"/>
    <dbReference type="KEGG" id="mbrn:26244804"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="36225" checksum="B124DBCAD3E3EEBC" modified="2021-02-10" version="1">MKDLSQASEWTKQQFNVSAIAGRGTYGKTFLPENVFLLPEPQDVQGDVHEPRGIALRVGSQITSLNAISAAEVDTSRRDMFWGSYRATMKLSHVSGTCAAFFWYFNDTQEIDMEFLSRQFDEVKKVFPVNLVIHSSLSAKDGYDASKTGTFKTTNLKFDPTKGFHEYRFDYLPGHVYFYADGERLGDMKGENVPSSGGHVILQHWSNGNQLWSGGPPSSDAAIVVKSVKAYFNSSDAEKRGDWHNTCRGHGEKGTVCAISDTTPATSGQVDHSPHNDAKAGNHETGEESGGYGSHLAKSLTTALAPMMAVYTLVMMGPELEFGLKAWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1C0</accession>
    <name>A0A7D5V1C0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g078890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545221.1">
        <property type="nucleotide sequence ID" value="XM_014689735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1C0"/>
    <dbReference type="GeneID" id="26241254"/>
    <dbReference type="KEGG" id="mbrn:26241254"/>
    <dbReference type="OrthoDB" id="5401786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="548" mass="61682" checksum="7352BDAD4FB909CB" modified="2021-02-10" version="1">MASFFHDPRRPALSQVVEALQRLQNDPQQLAHEREGRYDDPPPPYPESGETTQPPTPGPPVVDETYQRELRRKARYKATPVNQFNSQANRELERLVHQLSEKRFGRRQTLPWDGSSDLRANSENNVRSRWVEQGIWGNEWGPAWPEDSHPMSKRWQQEGDGPFFGSYSSSTSKSLPGARWGHEEPDPEPESESESEQERPPIFGIFGLGVGQPKRSKSPQRFRYIQTEQGQRLYIPNPTVRNPEASRPYNQFLYQISKERDWIKDELDYKALGTSVDIDTIVYQSVKDMWIEDGIWNPKWGELPGMTWIYEEPEEEEAVEAPASPDAVAGQHEDAIDDGRQHAPVPRTLSIFGQALISNMASGGTDGSSAPALGDAGASTTDRRTGTREAPSDQTAVTHDVQDPGDRPRRAARIERPPREERTPRLRKRSRGSDAVVDEQPPKRPRRSTRLSALPHNASDSADANKPHGSKTVDTSGVEEGRRPPCDKRAAPASGKTKGKKVNAVANPVRRSARIAERERKRMADMAEELPSKSRSPRAKTTRTARRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1W8</accession>
    <name>A0A7D5V1W8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase 5 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GH5FP</name>
        <name evidence="7" type="ORF">G6M90_00g088080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542307.1">
        <property type="nucleotide sequence ID" value="XM_014686821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1W8"/>
    <dbReference type="GeneID" id="26244821"/>
    <dbReference type="KEGG" id="mbrn:26244821"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028901218" evidence="5">
        <location>
            <begin position="17"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="63"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="417" mass="46144" checksum="E744D24EEB00801A" modified="2021-02-10" version="1">MKFMVQLLALSYGCLAFAASAVEKPNVPLRSSSRWILDSAGKRVKLRCINWAGHMEANVPEGLNKKHIEHIADWIAGQGYNCVRLTYSIDMALNPALKVQDSFRAAATAAGVSEADMMRVYTAAVEKNSFLSGATVLDVFDRVQSALWNRGVMTILDNHVSKASWCCDLSDGNGWWNDANFYVAATSRYFNTQKWLNGLKSMAQWSASRPGIVGMSLRNELRAHIAQIPWAPSTWLKYMPRAGDVVHAENPRLLVIVGGINGGTDLSPLRNGAMKLGNWADKRVWEAHAYSFTVVTPSLGSCDIRKAEFGGLFGFVLEQNKASTGPLLLSEFGVGMTGGPHDGLSNQDNDYLTCLVGYMENNDADWAHWAVQGSYYVRDKTVDYNETWGALDYEWSDWRNPKFKGMLGNMFAVTQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V296</accession>
    <name>A0A7D5V296_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541797.1">
        <property type="nucleotide sequence ID" value="XM_014686311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V296"/>
    <dbReference type="GeneID" id="26245265"/>
    <dbReference type="KEGG" id="mbrn:26245265"/>
    <dbReference type="OrthoDB" id="4203030at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="238" mass="26651" checksum="C8D20360C759CC8D" modified="2021-02-10" version="1">MTGPPTSPRYSAEDFETASVRSAAPSYVSDTPSYHTLPYNHNEAIPPYSPPAPRAAPLATSATAPLFAPGRHGTSSTRQQTIGLPPLPPVAPQGAMSIHNFHLPTWSANNGPAARHYRNVAERRITSGRYTGPAEPLRHQNSNDRALNNGTDTAPEARPLEDPYLVGEVAAAQARRERLARESSDDILVREDRQWDWLLAQMRSWDERERNWARFRREVEHTQRKKLLRRIGGRLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2C8</accession>
    <name>A0A7D5V2C8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SEC23</name>
        <name evidence="22" type="ORF">G6M90_00g088640</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cytoplasmic vesicle</location>
            <location evidence="1 16">COPII-coated vesicle membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
            <orientation evidence="2 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542251.1">
        <property type="nucleotide sequence ID" value="XM_014686765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2C8"/>
    <dbReference type="GeneID" id="26244765"/>
    <dbReference type="KEGG" id="mbrn:26244765"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="127"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="404"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="521"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="636"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QLI72313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="771" mass="85526" checksum="F1C84AB3713031A4" modified="2021-02-10" version="1">MDYEALKEQWSEVEERDGVRLSWNVFPSSRMEASRLVVPIGALYTPLKEKPDTPLLQFEPVTCKQPCRSVLNPFCQVDVRARVWICPFCLSRNQLPPHYKDITANAIPPELHPANTTIEYRLSRPAPAPPIFLYVVDLCQEEDGLTSLKESLVMSLSLLPENALVGLITFGTMAQVHEIGYEGCAKSYVFRGSKDYSAKQVQEMLGLSSSGIRPGSHAQPGRPAPMGPASRFLLPVQQAEFSLTKALESLQKDPWPTANDRRSLRCTGVALSVAIGLMESSFQNAGGRIMLFAGGPATEGPGMVVGPELREPIRSHHDIDRDNVKYYKKALKFYDNLAKRTAHNGHIIDIFAGCLDQVGLLEMKGLCNSTGGHMILTDSFTSSMFKQSFVRIFEKDGDDNLLMGFNAVLEVLTTKELKVTGLIGHAVSLNKKSVSVGETECGIGNTCSWKMCGIDPQASYGIYFEVASQGPATHQQTPQKGMMQFLTYYQHSSGQFHLRVTTVARNLSGPAGDPAIAQSFDQEAAAVLMSRIAVFKSEVDDGPDVLRWVDRMLIRLCSRFADYRKDDPSSFRLEKNFTLYPQFMFHLRRSQFLQVFNNSPDETAFDRHVLNHEDVGNSLIMIQPTLDSYTFDQEGGQPVLLDSASIQPTHILLLDTFFHILIFHGETVAEWRKAGYQDQEGYENFAALLEQPKEDARDLITDRFPLPRFVVCDAGGSQARFLLSKLNPSTTHTTGPYGGGGTASAQTIFTDDVSLQTFMDHLMKLAVSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2I6</accession>
    <name>A0A7D5V2I6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adh</name>
        <name evidence="8" type="ORF">G6M90_00g098410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987621.1">
        <property type="nucleotide sequence ID" value="XM_066131544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2I6"/>
    <dbReference type="GeneID" id="26240926"/>
    <dbReference type="KEGG" id="mbrn:26240926"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08286">
        <property type="entry name" value="FDH_like_ADH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF4">
        <property type="entry name" value="NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="7"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="346" mass="36500" checksum="F2D1A4BCE2D8ADBB" modified="2021-02-10" version="1">MKALVYSAAGSVSIQQKPDPEILLPSDAIVKLTKTTICGTDLHILKGDVATCQPGRILGHEGIGVVSSTGSSVSRFSPGDRVLISCISSCAACEYCRRGMYSHCTTGGWILGNSIDGTQAQYARIPHADSSLYKIPAGVDDAAMVMLSDIFPTGLECGVQNGRVQPGSTVAVVGAGPVGLAALMTAQMYSPSKIIVLDIDDKRLETARELGATATVNNKAEDAVARVKQLTDGKGCDAVIEAVGVPATFALCQELLAPGGVLANVGVHGSKADLFLDRLWDKNISITTRLVDTVSTPMLLRMVESGKLRAARLVTHRFKFDQMEEAYKTFGQAGQTGALKVLIDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V362</accession>
    <name>A0A7D5V362_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional methyltransferase subunit trm112</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eRF1 methyltransferase subunit trm112</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rmt-1</name>
        <name evidence="8" type="ORF">G6M90_00g095800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987707.1">
        <property type="nucleotide sequence ID" value="XM_066131500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V362"/>
    <dbReference type="GeneID" id="26241173"/>
    <dbReference type="KEGG" id="mbrn:26241173"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000021">
        <property type="entry name" value="Multifunctional methyltransferase subunit trm112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="127" mass="14027" checksum="7CA4ABF2AB1166BE" modified="2021-02-10" version="1">MKVLSLNFLTCAAKACKSSSDSYPLHPKDAELVQDEIELNPDMIINVLPRLDWAALRTTSSELGFPALPEQPPTAEELQADEKTLKDLHHLLLETQMSEGKLVCANCGHEYAVKEGIANFLLPSHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3H2</accession>
    <name>A0A7D5V3H2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter NIPA4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g087870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_066131316.1"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="41909" checksum="08DF747B746C3A00" modified="2021-02-10" version="1">MSSALAIGTSFVITKKGLIHAEERHGFEGDGFVYLKSPLWWAGIATLGIGEVCNFAAYAFAPAILVTPLGALSVLIGAVLGSYFLKEELGTLGKLGSAICLIGAVVIVLHAPPDEEIETIDQILDYALRPGFLLYAITVVAFAVFMIYRIAPQYGKKNALIYLSICSTVGSISVMSVKAFGIALKLTFAGNNQFSHPSTYVFLILTAVCILTQMNYFNKALASFPTNIVNPLYYVTFTTATLCASFILFSGFNTTDPVNTLSLLCGFLVTFTGVYLLNLSRGDPNGQKLIAGRGGYDATPTDMVSGFQTRRSMQARRSGDPSRHSIGSLHSDREGLIRAYDEEEAAGFGLTDLAEESEDEGSRSNGKANGKKEPHENGIELQNQKSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3U8</accession>
    <name>A0A7D5V3U8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nsa2_1</name>
        <name evidence="10" type="ORF">G6M90_00g097540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691101.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="65"/>
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    </feature>
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        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="29763" checksum="9FE99B4C032C1557" modified="2021-02-10" version="1">MPQNEYMERWRKLHGRRLDHEERTRKRAAREGHKASQDAQNLRGLRAKLHQQKRHKEKIQMKKAIKAHEERNVKTADEKEPSTPMPSYLLDRTNPSTAKALSSAIKNKRAEKAAKFNVPLPKVRGISEEEMFKVVKTGKKIQKKGWKRMVTKPTFVGQDFTRRNPKYERFIRPMGLRYRKTNCTQAELGVTVQLPIIGVKKNPQNPMYTQLGVLTKGTVIEVNVSELGLVTAGGKVVWGRYAQVTNNPENDGCVNSVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4H4</accession>
    <name>A0A7D5V4H4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RRP36</name>
        <name evidence="12" type="ORF">G6M90_00g096360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546698.1">
        <property type="nucleotide sequence ID" value="XM_014691212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4H4"/>
    <dbReference type="GeneID" id="26241121"/>
    <dbReference type="KEGG" id="mbrn:26241121"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="310" mass="35627" checksum="76670F6AA0EBB05A" modified="2021-02-10" version="1">MSSKRKVPSLGLERRVRPRREDKWEPEPESEDDLSDDHGPAEEGIGSPESNVDDDDDDEQDESAESDPESSDDTPKADLTSISFGALARAQASLPPAARKSKTPKPSDHQPPQETRRSLQKEPSKPPRTAPPKRSSKHAPLEQTSKRPVSRMREIIPDNRRKARDPRFDPSVNRIGKLDEAKARSAYAFLDDYRDSEMADLRAQIKATKDERARDELKRQLMSMESKKKSRASKDDEDRLLAEHRRKEKDLVAQGKTPFYLKKSEQKKQLLLGRYDRMTKGQVDRAIERRRKKVSGREKKELDGLQRRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4W4</accession>
    <name>A0A7D5V4W4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SPT6</name>
        <name evidence="13" type="ORF">G6M90_00g103960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987668.1">
        <property type="nucleotide sequence ID" value="XM_066131632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245642"/>
    <dbReference type="KEGG" id="mbrn:26245642"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI73439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1411" mass="163263" checksum="454AB3261AC94543" modified="2021-02-10" version="1">MSNSMRDLISGEAELDDEEDDESFDEETGEERVRRNGAHVDDSSEEEDDDEDEEEARKIREGFIVDEEEEEEEEVESDAESRHVKRKREHRDREEEERLDEDDLELIGEQFGERPKPESKSKFKRLKRGHRDEDDITNERRGLDEIFSDEDEDATEQRPYGRSNLRAQADEFDDFIEEDFPEDEDERTRRLEDLEVARPRDRGVGAVVDTTGLDKDALDDMEAIFGNGEDYDWALQLEDDEEDREKQEQGIELKDVFEPSQLKEKLLTDEDNEIRFTDEPERFQLERKSFKNLQLTAEQFKEEAKWITNQLWPKKGLTQELQTPFAKAVGKVLEFFIVDEVEVPYVFQHRKDYLLHSKKIRKSARDDLDGPDYTIQSDKLLNQDDLWRILELDIKFRSFVDKRNSLEKTYENLKSLDVEDPMVEEMIPEATTMEELQDLQDYLQFQYGAKLRDLAVMAGNHSQSKRPGSKSALLDRVRNGKAYYFVKAYGVSADQLAKNALRQGKKITPDDDSQYPMDLADSLIDDNFSTGDQVISAARQMYSEELFASPRMRKYFRSSYYQAAELSCRRTDKGLRKIDDSHPYYEIKYLQNQAIADLVHRPELFLKMMRAEEEGLVDIKVDMPPRYDFRRQLYQEFESENFSDRAEQWREERKKVLDMAFPKLEKVIVKNVKEVIRTFCQDEVLKMCRQEFYRKLDQAPYKPKGMILGTTPRVLALSNGMGDPTREPTCWTWVEEDGRVLEQGKFGNLARDEAQREEFAALVRRRRPDVIAVSGWSAETSKLVRDIEALVSDKDLRGAEFDDPETNDYRTEPLEVVVVDDEVARLYKDSPRAVAEHPSLNPVTRYCLGLARYMQNPMKEYAALGKDVSSLSFHPCQHLLPQDKLAKYLDSAMVDTVNMVGVNINDAMTDTYTANLLPYIAGLGPRKATSVIKAINANGGSVNTRDELVGDPDSGKLPVVGPRVWNNCASFLYIEFDSTNEITDPLDNTRVHPEDYELGRKMAADALELDEEDVKAETDENGPGAIVRKLFKQDEQERVNELVLDEYADQLLTNFSQRKRATLEAISAELQAPYEELRRSFAPLNQSEIFTMFTGETKSSLCEGMIVPVNVRMVRDDFAIVKLDCGIEGRVEAHEVTSRTSVKEVLSTGQTAQAKILELNYKDFMAKLSMREDALRVPFKRPINYGRDGWDYNLETTDKEELREKDQSTGRTQRVVKHPNFKPFNSIQAEEYLGSQPPGEVIIRPSSKGNDHLAITWKVADNVYQHIDVLEMQKDTEFSVGKLLRIGGKYTYSDLDELIVDHVKAMARKVEELMRHDKYQSRSRSETEKWLTTYIDANPNRSAYAFCIDQKHPGYFWLCFKASRTARVIGLPVRSIPQGYELKGYQYPDMRALCNGFKLRYQNEFSTMGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6V7</accession>
    <name>A0A7D5V6V7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g110730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543786.1">
        <property type="nucleotide sequence ID" value="XM_014688300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6V7"/>
    <dbReference type="GeneID" id="26243173"/>
    <dbReference type="KEGG" id="mbrn:26243173"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="671" mass="74830" checksum="D6559618657B73C3" modified="2021-02-10" version="1">MTASADQDNAQQRLAHRKSLRTRTGCLNCRQRKRKCDEQRPSCGGCRKKKHQCSWGLKLSFRHENAQHLAGNHPSMRRFSRHRPKQYEIVDVTSEVMRDYSLPPASQRNVVHDDHGDHFSAGRVARENRLLTGYSGGIQQTEISAPNEASRVDSCAAVGASSTDPETPPMNGIVSPASRRQTEISVADLSDASQRGQSTEPTHKSVHVRLDPTPVRSVADCDDLDHYQPFTPSGTYFEDGRFLPGSAYHESHSILRQQLIQESRRNVSTRPATRSAKVGGQDNDLCQDCNHDEPLGSVPDNLTAISKTTQAIVSTEEECSLWRNWFANVAPWLDIFDMERHFQHTLPALAPSNDHLRCAILALSARQQELKRPANPTDRSLALYQEAVRLLLPELASRSTAAVASCVILSVLETLSCSPESWHRHLDGCASFMGAVGINGFVGGVDQALFWCLARTDVCGALLSAPTLAVSTWSKSNTDDDVRLHQTKTCAGWANYAVHLTARVLNLLSSQTTNRRDPAFHTRWLRLWKHLCDWQESRPAPFLPVMSMPSTTTNTPFPTVIFSNPAATSATQLYHTASVLMLQHQPTEVTPPKARTALWHARQICAVSISNEHHGAWMNAVQLLWVAGRCIRHPAEHKAILDVLQRIEKETGCETKSRQEDLRSFWRGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMQ9</accession>
    <name>A0A7D5YMQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Satratoxin biosynthesis SC1 cluster protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SAT4_0</name>
        <name evidence="9" type="ORF">G6M90_00g000180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986053.1">
        <property type="nucleotide sequence ID" value="XM_066129480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMQ9"/>
    <dbReference type="GeneID" id="26244419"/>
    <dbReference type="KEGG" id="mbrn:26244419"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="312" mass="33959" checksum="EB6D741923D9A12B" modified="2021-02-10" version="1">MAWGIFNDPVQSLVFAVGLVFTPICVIATALRFIASRVSLGKIGIEDWLALGALVFYITWTVITAATYLDDMDFTKSSATSRLLPLVIATLMFAPNQLCAKLSILFLYHRIFGVKKAYSLWIKALGILQIIYTIPTMVIEALECWPVQKSRATNESCIVISAAFMARAEPVNSFVDFAMATLAIFMLRSLQTSRKTKWKLSLLFISGALAGIIGFIKAGLAFPAAYGNQIFMGVGTTVQMALSIICCCAITFRPLLTKTHLFSSLAAKILACGSRLLLVRKAFPPSSDRTSDHGINLETASGTRHPAVSNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNW5</accession>
    <name>A0A7D5YNW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547834.1">
        <property type="nucleotide sequence ID" value="XM_014692348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNW5"/>
    <dbReference type="GeneID" id="26237278"/>
    <dbReference type="KEGG" id="mbrn:26237278"/>
    <dbReference type="OrthoDB" id="4927418at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="233" mass="26176" checksum="297B46AE0094F199" modified="2021-02-10" version="1">MRNPKSPSGQYILAEAIQAFDKLRDLGWEIQFRWIPAHVGVPGNEAADKAAKEATGYDPSQQTSVDPPQEPNWLQTLTATTKSIIRTTMKEEWKQSWVKAKHGRELFRLGIRPGKKSLNTHTDKHRAISSVITQMRTGKIGLLAYLHGINRADTDKCPCGYGTQTVRHILLECRDWTEERVKMWAGKRPCVDIKRILCSSSMAGQAAKMILRTGLLGQFQAMPSTVLQYTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSN1</accession>
    <name>A0A7D5YSN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADA2_2</name>
        <name evidence="11" type="ORF">G6M90_00g075160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545580.1">
        <property type="nucleotide sequence ID" value="XM_014690094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSN1"/>
    <dbReference type="GeneID" id="26241613"/>
    <dbReference type="KEGG" id="mbrn:26241613"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01321">
        <property type="entry name" value="ADGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="230"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="585" mass="66525" checksum="DFE04FCF344CECF5" modified="2021-02-10" version="1">MAMPNDVWDEISQDIPSASDPFIQQYMAGRENLINQEKTSRSDTSFRKSLSPIAKRACTIVDRIRSHEHKTVWTPDVEEHMAQTSHECIFPGMMFMFAKDRMESTNLWKIVRKMPKGCLLHSHMDAMVNFDYLLDVLLGTPGIHMSSDRPLRGKDALENAAMNFRYKSSERTDGSLWEASYKPQTFILLTKAADEFPDGGRQGFLRWLKSRCTLSTTDSHEHHHGIDAIWRKFAKCFIVVATIIHYEPIFRAFLRRLMSQLKSDGVNWVELRFTWPLDYCRDRQEEPEQDYSHMFKVIEEEVARFKASPEGEGFWGLTTIWTTLRSIDTRPLIENMDHCITTKMEFPHLIAGYDLVGPEDLGKPLVDVLPELFWFRKQCAQEGINIPFFFHAGETLGDGNSTDSNLFDAILLGTRRIGHAYSLYKHPLLIDMVKDKRILVESCPISNEVLRLCGSVLAHPLPALLARGVACCLCNDDPAMLGQDTAGMSHDFWQALQGWDNLGLAGLGSLAENSVRWAAFEDQEAAAWANDIRQASLGSGIKAERLKQWQVEWEQFCLWIVTEFGDEFDPEGETTGAAEAEAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSV7</accession>
    <name>A0A7D5YSV7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g078500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545258.1">
        <property type="nucleotide sequence ID" value="XM_014689772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSV7"/>
    <dbReference type="GeneID" id="26241291"/>
    <dbReference type="KEGG" id="mbrn:26241291"/>
    <dbReference type="OrthoDB" id="10284803at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="92" mass="9912" checksum="9796288C4F01CE9B" modified="2021-02-10" version="1">MIVTRRVASAALKPGIPWRACPQRRTFADISGANKPARPAEIQNNTTLWMTGLAGAGLAACYFIFLAKPEAVGSEVTGNPEKARDPKMAREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSW4</accession>
    <name>A0A7D5YSW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">COPE</name>
        <name evidence="12" type="ORF">G6M90_00g074640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545604.1">
        <property type="nucleotide sequence ID" value="XM_014690118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSW4"/>
    <dbReference type="GeneID" id="26241637"/>
    <dbReference type="KEGG" id="mbrn:26241637"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000613">
        <property type="entry name" value="Coatomer subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="294" mass="31547" checksum="C41EF7BF4162F45A" modified="2021-02-10" version="1">MDPYSAEGELINIHNHFHQGQYQEVVDFDTSSFSADNALPARVLVLRARIALGQAEDVVAEVKGAGQPDLEVLGAYAEYSLGKTDAALKTVEKLASSAADNVTVQVVGGTVLQAAGKSEEAIALLSQHQGSLEAVALIIQIHLQQNRTDLAVKEVSAARRWAQDSLLVNLAESWVGLRVGGEKYQQAFYVYEELAQAPSTASIRSLVSQAVCELHLGRLEEAQTALEQALDKDPEYIEAIANMLVLTVISGGDASDYAASLKTVDPNHALLVDLEAKSDLFDQAATKYRAKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU74</accession>
    <name>A0A7D5YU74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">alg-10</name>
        <name evidence="17" type="ORF">G6M90_00g019120</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548628.1">
        <property type="nucleotide sequence ID" value="XM_014693142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU74"/>
    <dbReference type="GeneID" id="26238072"/>
    <dbReference type="KEGG" id="mbrn:26238072"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="389"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI64065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="725" mass="81968" checksum="9AE31CA07BF8D37D" modified="2021-02-10" version="1">MADSTEVTRSWASPLATLALSIPILILVSRRTGTKWQNFPPFFLLTLLSGAWFMIVSETVSEPYLDEIFHIPQAQRYCEGKFLEWDDKITTPPGLYLFSILLQKTAATVKLPWVFSCDTSSLRITNVLGLIVLASLTLLCRHEIESRLYEAHSSVRLKAISKYAVHTAFNIALFPLLFFFSGLYYTDVISTAVVVGGYLNHLKRVGRDRSSFVSDLITVLLGTLSLFMRQTNVFWIVVWMGGLEAVHALKTLRPQHAEQPFMTTLTDQVKFYAWRYSVGDVHDPPLNLAWPDDMLFTAISLGIAALCNPIRVIRQIWPYLSVLAAFASFVAWNGGVVLGDKSNHVATIHLAQLLYIWPFFAFFSLPLLLPHVIPILDIAGNVSRSLSQSGQRAGSSQPSKTSRSFESSRSVKSKRPEGSKARDTRSTVSQVALETPSLGSPSPALRTADFIFNSKFIPWIIYTLLTFVVSTAIVKFNTIIHPFTLADNRHYMFYIFRYTIRRGSLIRFMLIIPYTISRWMVWGTLAGCADWISSSNRELCSARYNVNEPAPYTSHPLWIARGTKKTQTNVEYPQDMSLVPSSSASTDGELRGTVEDDPLLVSAEPTSTSTGLIFLLATTLSLMTAPLVEPRYFILPWVMWRLLVPAWRVHDHAHINSLFEGVAPRSIVGKTKEIFKRYDVRLVLETLWFVAINVATGYIFLMKPYVWKDEQGRNLEDGRLQRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU95</accession>
    <name>A0A7D5YU95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TYW1</name>
        <name evidence="19" type="ORF">G6M90_00g024380</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548143.1">
        <property type="nucleotide sequence ID" value="XM_014692657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU95"/>
    <dbReference type="GeneID" id="26237587"/>
    <dbReference type="KEGG" id="mbrn:26237587"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="123"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="446"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI64125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="792" mass="88966" checksum="39AE95A2402955F3" modified="2021-02-10" version="1">MSAVCEKTDPLQGVFGGLPGAKFDDIVELWHGHRTPIIICALVVLVVIRIYIHKLEEAEPLRALPKQFEKRIEPLSANKLPSAVNSEKPVAKPNGPRRIKGGITKKPATEETKEYDKSRPIKMMVFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGTERQFLKPELHDLAEIDFEDFFVSPAKTVEDAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGFGDKEGWPDEADGYCFQAKELDRWMSKLTGRKRAYPVGMGDMKSDHAERFDEWSSGVQEVIAHVASSGTLGEGAPGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGRMLRTSDGKGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPHINEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCEFVKALEGRLKAKGLKYGIAAEHAHSCCILLASERFLVNGKWHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIENIVVREAPPPDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUR9</accession>
    <name>A0A7D5YUR9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketoreductase CTB6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CTB6</name>
        <name evidence="4" type="ORF">G6M90_00g017160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548814.1">
        <property type="nucleotide sequence ID" value="XM_014693328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUR9"/>
    <dbReference type="GeneID" id="26238258"/>
    <dbReference type="KEGG" id="mbrn:26238258"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="340" mass="35893" checksum="45306B221FAD7264" modified="2021-02-10" version="1">MTGDIVLLTGATGMIGFKTLVELLENGYTVRAAVRNQAGFDRISSLPSLQKYKPPQLTSFIVPDITVPGAYDEAVKGAKYIVHVASPIPDNSGQDHETSLIRPAIQGTVGILESALKATGIKRVVITASVASIASSARMATGEVINENTLDVETQPPFADDLAAYAASKALAYQATRDFVSAHKPPFDVINIMPVFVFGRDETVTEAGSIAKGTNGILIGPLLGHAGGYPLRGASVHVDDVARIHVLALDPKVPGNQDFLAAAAEAGGVDSARSFEIVKRRYPGEYADGVFKFDGGAEPSATGARVDGTKATRVLGVQYKTFEEQVVSVVDHFLELTGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVP2</accession>
    <name>A0A7D5YVP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g069990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540676.1">
        <property type="nucleotide sequence ID" value="XM_014685190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVP2"/>
    <dbReference type="GeneID" id="26246549"/>
    <dbReference type="KEGG" id="mbrn:26246549"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50943" checksum="7C36EF223CED97B6" modified="2021-02-10" version="1">MVNLATLQVGGLRYNSPWTQVSIVGFVAFCSVGMFSAISNLGAGGTQDVQLSDIANSVLYGMFFLGGFFGGSINNILGPRLTMSIGTTGYALYLGSLWCFQLNGTRWFLILAGGILGVSAALFWAAQGAIMMSYPLEKDKGRAFTIFWSLFQTGTLIGAAIALGIEFNSTMPGVSNGVYVAFMIIMLTSIATSWLVLPPQAVVRGDGTIVRIAASLTPKQEFMEFLRMFKDWRMIALFPMFFSSNYFYAYQGAITAFLFNGRTRALVALLTGLGSIIGSIIIGFVTDNLPFNRRKRALWSCAFVTFLICLVWASGVAFQTRFVRGQVFVDDEKVPWDWTVGVAAGPIVLLFGYYVVDAAYQGLAYYTMSSISNDPFKLARMAGYYKGIQSAGAAVSFGMDAVMTPYLGEVLVSWLLTMVALPLCALVLYHVPDSNYDIEGVAHIEDVDAKDAEGISAPPDHQRKDSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVP6</accession>
    <name>A0A7D5YVP6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g076950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545408.1">
        <property type="nucleotide sequence ID" value="XM_014689922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVP6"/>
    <dbReference type="GeneID" id="26241441"/>
    <dbReference type="KEGG" id="mbrn:26241441"/>
    <dbReference type="OrthoDB" id="3642468at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="500" mass="55782" checksum="9A177DA984CCBF09" modified="2021-02-10" version="1">MEDIYRNLSSLDHWGRGYGPETCFQVTELWQNGSTGTVTTLTKKIDPINVDGWLAQETSSGAEGDAQALIVRMVWIDVDLSDKVIRQSEKTTSFLVNAFGLKLAYGYARSCVSGTAALPSHVHGEDAQFQSFCFCYPPKIATVWSCRRPRNGGPGRRTLTQGIFFAQEEEKNALQKALLGQWSLGVYRNPMFPSLLLALVIGAQIDLTTAVIKNDIRGVEKRTGYHNFASRQGEKRSEGDLEELLAKTSGSASKLASTSRKSKVLEKLLSFMRKTLEESEIGLQDLLPDAAPERPGSDGTNESPTGSSVLKSHVSVLQDRQEMQVTDIEYTLKRVQVQSDALFNIIQQYHANFNLELSRSTEQIAFFSYRDAASMKTLAVVTMFFLPGSFISALFSTNCFEWAGVDLRSGSIGVKPTPQMSLYWAITIPLTGLTFVLYVVWLAFQKRERDNMVKDQMRGRDGGDLWLDRSMVPESLEEAEDRKLARTRMTIDFGGPQLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVR3</accession>
    <name>A0A7D5YVR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g050970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986314.1">
        <property type="nucleotide sequence ID" value="XM_066130498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVR3"/>
    <dbReference type="GeneID" id="90967756"/>
    <dbReference type="KEGG" id="mbrn:90967756"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="80" mass="8746" checksum="429A6A8D23D3B72C" modified="2021-02-10" version="1">MASHRGNQAVGLLNRHPLASIVSPQDGLIRQISKPPQLESLTTIPAVPALGGRRVLVLSFKVDRQQAKRLRAVDDARMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVY3</accession>
    <name>A0A7D5YVY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">eca39</name>
        <name evidence="12" type="ORF">G6M90_00g079640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539936.1">
        <property type="nucleotide sequence ID" value="XM_014684450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVY3"/>
    <dbReference type="GeneID" id="26247274"/>
    <dbReference type="KEGG" id="mbrn:26247274"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000012">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF69">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="44889" checksum="E15BBB171A9F0849" modified="2021-02-10" version="1">MAPSAVPQQDVNLTAAAIQRKEASVANGDGGQKAPLDASKLTYSLTKSPRPVPDQATANAGDETIATDHMVTATWKASTGWGAPELKPYGPLSLMPTASCLHYATECFEGLKVFRGHDGRLRVFRPDRNCARMHMSAGRISLPLFEPAELEKLLVALLAVDGPRWLPADQPGHFLYIRPTLIGTQSQLGVQAPREAMLYIIVTFMPRMDSPPGGMRLHTSPEDMVRAWVGGFGYAKVGANYGPSLMATQDARRRGFHQILWLYGAQGECTEAGASNFFVVWVRKDGKKEIITAPLDDKLILDGVTRRSCLDVVRERMAGEIEVTERKYTIDELVEADAEGRILESFAAGTAYFICPVSQIHHRGKDINIPMGPEGTAGEVTTKIKTWIGDIMYGREQHEWGVVIAEKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWQ9</accession>
    <name>A0A7D5YWQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol-specific monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fmo1_0</name>
        <name evidence="6" type="ORF">G6M90_00g002770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542806.1">
        <property type="nucleotide sequence ID" value="XM_014687320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWQ9"/>
    <dbReference type="GeneID" id="26244179"/>
    <dbReference type="KEGG" id="mbrn:26244179"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="480" mass="53999" checksum="ACDF54AC2B4A756C" modified="2021-02-10" version="1">MPGVTVKRVAVIGAGPAGAIALDALAKEKTFDLIRVFERRERPGGCWVGDTLPPPTLSDFKSLADRTADAPIALPETLPAFTPKSDQPRFTESSVYPYLETNISHLPMQFSQEPFPADISERTRALYGDGSPFRHWAVVRSYITGLCERNGYEDLISFSTTVERVDKIGSEWKVTLRKEGKDSDYWWTEWFDAVVVASGHYSVPYIPAIEGLEQFEKSRPGSVMHSKHFRGKDKFRNKRVVVVGASVSAADIAFDLADSAAFPVHAITIGHNLNGYFGGEAFEHPKIEKLPSIAKVQGRTVLLVDNKTIPDVDYIVFGTGYSWTLPFLPQVPVRSNRVPDLWQHIVWQHDPTLLFVGAVHAGLTFKVFEWQAVYVARLLANRAAPLPRLDEMRRWEADRISRRGDGARFSLLFPDFEDYFESLRGLAGAGEPGVGRKLPRFRREWFREFLDGHELRKDMWRRHNKAAAGAGSTRTLDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXN2</accession>
    <name>A0A7D5YXN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g101370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546209.2">
        <property type="nucleotide sequence ID" value="XM_014690723.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXN2"/>
    <dbReference type="GeneID" id="26240632"/>
    <dbReference type="KEGG" id="mbrn:26240632"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="56"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="500" mass="55360" checksum="CEAD8335B334A051" modified="2021-02-10" version="1">MVNLTGVNLCPPPFVDSNLYLHSKGYLEGRLCQKVADDLKCCLPCPMTDWIYPDSFNSMTVAANWIAAVSAICCVYLLASWAALPVDKTNRHYLSVCLTIGVLLMNLGFVIPLAARPDQCYDKITPHSMSTSKVCGASGSFLLLGGWCGVMWAFLRSLSLHLQICWQVLVGRSFMIFAQAAGWGIPLLGITLALVFSGVSFRFGSTCHLNHKNSLADVWIPLLIFAGATVIITFATFGYCVKVYLASLYDNSASTEGSSLPAYTSSVRTVSPRQAYRRVKRVIALQWRGIAIVLIIIADVIFFSVIFVFQDNVVQSVTNDPSMAKDWVTCLIGAGGDKNQCLKYAGSIVVNEATVTAVLLLLGLNGIWLMFLLGRISMFTGWYELFTSFLPSSRRQKEFVSVDARHDTKKELRNSRSYEMLSRDSSVVVTPLSPVKSPSPGRRTPDYFGQAARYNVPVRSFSSPRGPQTASWDHQETFARPERPERTDRQDMNPLGMNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYG4</accession>
    <name>A0A7D5YYG4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RCL1</name>
        <name evidence="7" type="ORF">G6M90_00g097960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546547.1">
        <property type="nucleotide sequence ID" value="XM_014691061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYG4"/>
    <dbReference type="GeneID" id="26240970"/>
    <dbReference type="KEGG" id="mbrn:26240970"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="208"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="404" mass="42578" checksum="987B27D6517D7014" modified="2021-02-10" version="1">MSNSPEFLRFTGHRSFTKRLTLSTLTGRPVHISKIRSTSPTNPGLAPHEISFLRLLEAITNGSSMQISYTGTTITYHPGLITGVIAGQGATDGDVLVHKIPDTCTRGITYFLLPLCLLAPFSKAHMNVRFSGAGVITSATETGDVSVDTFRTAILPLFALFGIPPVRIELRVLQRSCAGPGGKGGGGCVELRFASQVRLPKTLHLNRSPGRIKRIRGVAYSTGVSASNNGRMIHSAREVLNPLVADIHVAAQYDQAPLVPTGDKAGSKRRLGIGFGLSLVAESSAAGILYSADVVVPPSGGMVPEDIGKKCAYQLLEAIAEGGCATQISASAMLILMAMGSEDVGRLRIGKKVLATEDMVSLARDLRTFGASSWGLRDVEDDESGDIIVSVKGTGVGNVGRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYI2</accession>
    <name>A0A7D5YYI2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g095050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540862.1">
        <property type="nucleotide sequence ID" value="XM_014685376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYI2"/>
    <dbReference type="GeneID" id="26246475"/>
    <dbReference type="KEGG" id="mbrn:26246475"/>
    <dbReference type="OrthoDB" id="5089838at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="205" mass="23736" checksum="04A2ABF3091C295C" modified="2021-02-10" version="1">MSTPPYNVPFGDVNGIISKLECEQARQRAVDRETTPEAIFQTDAKHSYKLECELLHAKYEDDEIDRIRLGIADSKYWQKDADSAAHCLLTALLAKSRKRHTTDGVTDFRSMSTELRRLSEEQGQSSQQFRRQRDTITDEQYWEKEAEHFKRESARREFETREKWRSDLGAILSPAQSESDDGGKTATQEFLHSRETMPSVMPKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYL8</accession>
    <name>A0A7D5YYL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear condensin complex subunit Smc4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g044910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547820.1">
        <property type="nucleotide sequence ID" value="XM_014692334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYL8"/>
    <dbReference type="GeneID" id="26240383"/>
    <dbReference type="KEGG" id="mbrn:26240383"/>
    <dbReference type="OrthoDB" id="5394947at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028843179" description="Nuclear condensin complex subunit Smc4" evidence="2">
        <location>
            <begin position="18"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="86213" checksum="8BD91E48410DFF91" modified="2021-02-10" version="1">MLLFFILALLHAVSVFASGNIVLVCTKDALYSSLYQNGRQFCSSVLGKPPCEVVTPTAYATYDPAVISSRCSCVLMDKCLPRPTDSSSTTTRAASSTVSSTSSSHLSRNRTCSDHATSTAAGGTSSTKCAASHTVSSSSNRTTVDIDSTAVYTSSSVSTSYMYTNSSSSISYSNTTSSVSPTATVSSVLSGITSSSSSTHSLNSSTSSVTHSTDTQSSFKPWSSSQSSSTNGTSSKTSISSTSDSVTDSWLLPTITLTPIPSANISTVHLTLPGSSLLSTSTNATSTVNRTVPVSLLTHDSTSGSISSKTSSLLVSTINTTTTQTLSKLSTSAYISTSASTTSSPSLSVANFTLVTRTAAIAEETCYQFPQDPDAGNKDRSATLHNDQVAERNITLPSPYIESVFFDSAGIDPIFLTLWDALNGTYYMDVSNRSRVSIMDSQKNSMLIDANGIHFSTNTCAFDVSITIQDMYEQLESLSGEVCAKSISNKRSMEESSFEQVLFLKDQCGNGIKRALRTYPTLSVGDSDCMDTEVDSSTGKWTFLCPFPGSDSGNSRCRASVNNDIVRFLFTDPFGEACPDLSTVATTLAATARDFLNEHSLEEELYQLPLSGTQKSQVDATVKKYGQLWNVFKQALAKGTAGTPGQGSSTLEQYINMYNKYRSFEGDICNDLHAGDLPLNMSLRAGVTTIDSITSLKAAPENPKPFNITVQDSNQIACCKNGSKSSLNRPRGTCSYPENATVGDSDCVCGQTPGGDAIAFEYMECANFVSRCTSDDDCAKAGYKTYKCLTGSCCGGGVCFDPYACSQKGVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYS9</accession>
    <name>A0A7D5YYS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOD5</name>
        <name evidence="10" type="ORF">G6M90_00g100960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI74002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546251.1">
        <property type="nucleotide sequence ID" value="XM_014690765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYS9"/>
    <dbReference type="GeneID" id="26240674"/>
    <dbReference type="KEGG" id="mbrn:26240674"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028882634" description="superoxide dismutase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="9">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="214" mass="23072" checksum="755982131386E103" modified="2021-02-10" version="1">MRVAATVAALGAAVNVVLAADLLPEITDNPLDVIYTATLPQDPFFHAPELDGNIRGFISAAAPPDGLGVRFTVRFENLPKTGGPFPYHLHVNKASNGNCTATGAHLDPTNRGEKPPCDAGSLPSCQAGDLAGKYGKITSDPFIVEYVDKFVSLKEGDATFFGNRSFVIHLANSTRITCADFVKNDPDIPYGDDQHIHYIHYTNKIYSDRHGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ65</accession>
    <name>A0A7D5YZ65_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multisubstrate pseudouridine synthase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PUS7</name>
        <name evidence="5" type="ORF">G6M90_00g014450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985846.1">
        <property type="nucleotide sequence ID" value="XM_066129751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ65"/>
    <dbReference type="GeneID" id="26238521"/>
    <dbReference type="KEGG" id="mbrn:26238521"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="333"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="731" mass="81501" checksum="0A244E221526B6EA" modified="2021-02-10" version="1">MSDKDKEHFNARAGSSYAASIGITHRTTPLKCSWTGDMRVRFSDFQVNEINTDGTVLHLRTIGLGNERTQLEQPQNSESNARNEDSSTPQDEKPQPEQTIEVPQEDVKVLEDLSTAQFAQDLVKLFNYGNGPSSNDANTATSPVIDDKPKRAQLHQEVRRIFKSRLETTTGHDGVIVANYVSPRKGKKSRGRRGQPGDDGPMGDYLHFTLYKDNRDTMDAANQIARLLRVKPQIIGYAGTKDRRASTTQRCSVRHQRKRALAGLNGKLWGISTGDYEYQEQPIHLGQLLGNEFVITLKNCKMAGETAAQSPSERLASMRNNVEPALKHMSSHGWINYFGHQRFGTHDVGTHQVGKLILGDDFEAAVNALLQYDPEIAAKAEAGQVPDEPSKKDDALRHLACMLFQTGKDLNRAVKVIPRRFAAESCILRHLTRMGKNSARDFAGAITHITRGLRSMYLHAYQSHVWNHAASQRYALHGNKVAKGDLVISDGETQPAAAERERDQDGDEVINPVEDEEDAPLRARALTEEEAASGKYTIYDIVLPSPGYDVIYPDNEIGQFYQEFMGREENGSLDPHKMRRLRREFSLPGRYRKLMQRFLVEPTVEFKLYEDDTEQMHPTDLDLINGAKKNGIQGKRKRDEDDRGPAKKIKADDGEGQAEAKMETANSEQEATSSNGAEANTETELPAEPTKIAVVVKFQLASSAYATVTLRELMGDRLDEVTPSDEGVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZB1</accession>
    <name>A0A7D5YZB1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinyl-3-ketoacid-coenzyme a transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g042990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547633.1">
        <property type="nucleotide sequence ID" value="XM_014692147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZB1"/>
    <dbReference type="GeneID" id="26240196"/>
    <dbReference type="KEGG" id="mbrn:26240196"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53993" checksum="39D5B9C055131E25" modified="2021-02-10" version="1">MFDKSSGQVYREWTVPRQSLTVHGGDRDWSRRRPYPLFTPRGTKGPRSLMDMATHVIANNIGDVTERHLLDSMPVRLLWRIWLFLEARGVCLHAWKLFSKILVADDEDKTLGLYRFRQHICHPQEELKIYTQPLMSPSTDFIAHLVISGGCQFSTHELLCLAGMKSLGVLELIQPADEVRASFPEVSDRLIRGWAEMENPFPLLRVLRIWRDQDATQESLRWVTKFPSLALYDVMASRGDWPDPSGSALEHGWEMAGSASGMEDSLLRYLMLFAPLEQIRSSRLRDLARRVDADLSSLCGDSRCAVKFVTDRQAPPLLDYLTDTANAYLPTWDIEASSRDVGSCHGIAFEAWAFWLYAFIGQLGGDEDLRSRGVQSDTQAVVGPFILPSKPFASLFLGHNGRGGITNTPSYVSRGLFATKRMTFTRPPNLQGRDEPPLPQKMSRKTTNLAWDDQVEHSLRSKKRQRLDDILQSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZK3</accession>
    <name>A0A7D5YZK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g034210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZK3"/>
    <dbReference type="GeneID" id="90967607"/>
    <dbReference type="KEGG" id="mbrn:90967607"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="26529" checksum="59357A382A389840" modified="2021-02-10" version="1">MLQGFLTQLRAYHRFYPNKLTDVQVKVLHAGGYMTGTALAWFEPIMRDYLTNAGDDQEDEIKEIFADYKKFEKAIKKTFGSTDEDELYREDMPNNFLDYVVMAVRINNRQYQRRMQKQQGRGTWNPTGRRGQQANQKRRREEPIAYSHTLNPGRMELDATKKDNRKEKKCYNCGKPGHFANKCKKPRKEWKPVPEGVTEPEVEYKNLNWTFCYDDNCYVHMSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZK6</accession>
    <name>A0A7D5YZK6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g002580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542824.2">
        <property type="nucleotide sequence ID" value="XM_014687338.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZK6"/>
    <dbReference type="GeneID" id="26244197"/>
    <dbReference type="KEGG" id="mbrn:26244197"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="421" mass="47278" checksum="C28BFFEB52779DF6" modified="2021-02-10" version="1">MFRRHWSGLPKDATFPSDLKGLGYFVNDDDEIRSVESPEQYFKFFINKNERINQCQRFEFDKALEDIIHQRLVAEGLDKVALPLGSTTSEKHIVVFATPDLPSKSRIIVFFGEPTKVLGMLAGRVANGPGGINKGSLVSVVQELQKQVASNKDSSPPGVFIANPGQLYWWPEGRRMLTATDSTAIPLPSLVHAGRRHIPEINTVIAHETPEKHVESVFSTLLQVMSERTKVDLIAIGQSCELVTKFLDDATNWHAWKDHLDAMLLMGTVYPADLTNQALRDFTAKRARAYIVSTEPLDTPLAPPSGNEEEQIPAFGCPCYSSSEPFYAEMVLIRALKPALQYLETVALTPGYENDDILVAEKPKQEFTDKDWEKVADSEKPLIRVVDADLMKQEVKNRKRWRKFLENGEACDTDSSDDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z020</accession>
    <name>A0A7D5Z020_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ERG24</name>
        <name evidence="14" type="ORF">G6M90_00g016500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548880.1">
        <property type="nucleotide sequence ID" value="XM_014693394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z020"/>
    <dbReference type="GeneID" id="26238324"/>
    <dbReference type="KEGG" id="mbrn:26238324"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI63508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="489" mass="54437" checksum="95E29AC399F1F04E" modified="2021-02-10" version="1">MSSSKTAAKSAPPAKHGYEFFGPPGAFGISFGLPILVYVFTFVCNDISGCPAPSLLGPRPLSLEQLKIEVGWPQNGIWGLASWEATGAVLAYYLLNLILYRVLPATEVDGTVLSSGGRLKYRFNTFYSNTATLAALAAGTVAQGVEFPVWVFISENYLQILTANIGISYAIATFVYVRSFSVKPGNTQFRELAAGGCTGNLLYDWFIGRELNPRVTIPLIGEVDLKEWCELRPGMMGWIILNCAWCAQQYRNFGFVTDSIICITIVQALYIIDSWWFEPAILTTMDITTDGFGMMLAFGDLVWVPFVYSMQTRYLSVHPLSLGPAGLAGTLSLISLGFYIFRSANSQKNTFRTNPNDPSVAHLKYIETNTGSKLLITGWWGIARHINYLGDWIQSWPYSLPTGLAGYQIMAAGAGAAGQGAYIMKDGREVIQGNARGWAVPITYFYIVYFAVLLIHRERRDDEKCHRKYGEDWDKYKKIVRWRIIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0B5</accession>
    <name>A0A7D5Z0B5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Valine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="4">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cyt-20</name>
        <name evidence="19" type="ORF">G6M90_00g012490</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549273.1">
        <property type="nucleotide sequence ID" value="XM_014693787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0B5"/>
    <dbReference type="GeneID" id="26238717"/>
    <dbReference type="KEGG" id="mbrn:26238717"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000009">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000005">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="17">
        <location>
            <begin position="127"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="18">
        <location>
            <begin position="793"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1003"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI65286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121244" checksum="619BD6FDDB7A0FBC" modified="2021-02-10" version="1">MASNSARGGPVGANEGAETPKPAAQTTVPDIGAPRAADGAPKEKSEKDLEKERKKAEKAAKIEAKKAKAAQMAANAANKEKKAKEKKAEEAVPPYVEDTPAGEKKRIRPFEDPNFKAYDPIAVESAWYDWWEKEGFFKPEFTPDGKVKEAGSFVIVHPPPNVTGSLHMGHALGDSLQDLMIRWNRMNGKTTLWLPGCDHAGISTQSVVEKMLWRKEGKTRHDLGRTKFVETVWEWKEEYHKRINKALTHMGSSFDWSREAFTMDANLSAAVAETFVRLHEEGIIYRANRLVNWCTHLNTALSNLEVENKELTGRTLLDVPGYEKKVEFGVIVHFKYPIEGSNETVEVATTRIETMLGDTGIAVHPNDARYKHLVGKNAVHPFIPDRKLPIVADEYVDMEFGTGAVKLTPAHDPNDFNLGQKHHLEFINILTDDGLMNENAGLYKGQKRFDVRYSIQDALKEKGLYVDKKDNAMKVPLCEKSKDVIEPRMKPQWWVRMKELTGPALEVVREGKIKIRPDTAERSYFRWLEDIQDWCISRQLWWGHRCPVYFANIEGVAKDTADDKLWFSGRTREEAEKKAAAALPGKKFTLEQDEDVLDTWFSSGLWPFSTLGWPNNTHDLDTLYPTTVLETGWDILFFWIARMITLGLKMTGKIPFSEVYCHSLVRDSEGRKMSKSLGNVIDPLDVISGIKLEDLHQKLYQGNLHPSEVEKATKYQKTAFPDGIPQCGADALRFTMINASTGGGDINLDVKVIHGYRKFCNKIFQATKYVLGSLPKDFAPAADGVIRGKTLAERWILHKMNSAARDLNVAIADREFQKSTNIIYKYWYAELCDVYIENSKAIIRDGTEEERQSALQTLYTALEWALTLIHPFMPYITEEMWQRMPRRPGDNTKSIMVSKYPQYSPALDDPESESAYELVLAATKATRSLMSEYSLKENAEVFVQAYNEAALKTCNAEVASIKSLSGKSVKTMHVIGPDAPRPAGCVAYPVSTSVAVFLHVKGRVDMDAEISKAQKKLEKAKMSIQKQEKILFDPGYIEKVSAAVREGDEQRLADAKQEAISFEETIKQCEQLKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0E0</accession>
    <name>A0A7D5Z0E0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcium channel YVC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YVC1_2</name>
        <name evidence="5" type="ORF">G6M90_00g026560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547931.1">
        <property type="nucleotide sequence ID" value="XM_014692445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0E0"/>
    <dbReference type="GeneID" id="26237375"/>
    <dbReference type="KEGG" id="mbrn:26237375"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="37"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="257"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI63449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="658" mass="74922" checksum="6E6DA912676615AF" modified="2021-02-10" version="1">MDSQEDWMSDERAAEEPEVDLLEPDECEPESVYVTLHRVRRLVLASIDDPYTLDHFRQPSLNALIVRPLVDRLYETQNISIVYCLLANRVFFLKSQSGLATQSVNRARATLCELVATRVIRRFHEDNPGNEGLLLLAQILVEGFDPFDGAPYEVEREGRYLQWPIQRRGGHERKLTALELAILSESKAFISSAACQRLVEAVHMGKVVYTPLSFMDILPDHYKHRPIQLYDPRESRILNHRRLIVPRVRALIEMVQFMVLVLLYVMTMTNQQAASSQWELAFAVYTAGWVLQEFASVIEHGWELHSQSLWSFLDVTFVAIYAAYVLGRAYDVLAGRLPNGYGLHILCVAAPVLLTRIAFNVMPHNIVFISLHAMMRDFTLLTFLAVWCFLGFLLALLWLYDAGQTDQTSTAAPPPAWPTVGKWLLWIWFGLDGTGIAESVRFNIVLGPALMIAFAFLGNTLFLTILVAILTNTFSHIVANEAAEIRFRRTVLTFEGVKSDSLFAYPPPFNMLAVLAVLPLKFFVSPRVFHTINVAVIRVLNGPLLVAISIFERRRLWAAENKRHRRRSPGLLFGWRFTGFSPHGDIQGVFTAPLPDDVSARIHLLDPVDDVPVLEDDVMSTLSGDVPRSRLRRPKLWAGRREYPRARPRRRSPLRFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0R3</accession>
    <name>A0A7D5Z0R3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g068230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540579.1">
        <property type="nucleotide sequence ID" value="XM_014685093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0R3"/>
    <dbReference type="GeneID" id="26246686"/>
    <dbReference type="KEGG" id="mbrn:26246686"/>
    <dbReference type="OrthoDB" id="4749603at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="202" mass="23414" checksum="9EC926C79CE1B8E8" modified="2021-02-10" version="1">MSASSHPSSSSAGEHGSTPKGPNKKRLWRLLSAQGRVTKAFKVERTREWIKQHFPSVQDQVMKPPEAEQKPEWIKQQRPSTQDQAMKPLEAKRKPEWIEQQPLSAQGQAANPPKAKRSFWEWVKPQRLPAQDQAAKPAEAKRNPEWVEQRLPSTLMATTLEKFLHDKHGDQYFVEMRFDQYTLFAPEPMTEAEIRLCERGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0S2</accession>
    <name>A0A7D5Z0S2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HDAC1</name>
        <name evidence="12" type="ORF">G6M90_00g026200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547963.1">
        <property type="nucleotide sequence ID" value="XM_014692477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0S2"/>
    <dbReference type="GeneID" id="26237407"/>
    <dbReference type="KEGG" id="mbrn:26237407"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="454"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI63848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="652" mass="72665" checksum="97056B7249C5E097" modified="2021-02-10" version="1">MGDSNLAQAQAQLGSVALNGSSPKKVAYFYDSDIGNYAYVTGHPMKPHRIRLAHSLIMQYNLYQKMEIYRAKPATRGEMTQFHTDDYIDFLQKVTPDNMDSYMREQGKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRQKCDIAVNWAGGLHHAKKCEASGFCYVNDIVLGILELLRFMKRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGIGQGKNYSVNFPLRDGITDQTYKSIFEPVIESVMKYYQPEAVVLQCGGDSLSGDRLGCFNLSMDGHANCVNYVKSFGLPTLVLGGGGYTMRNVARTWAYETGVLVGQEMDRTLPYNEYYEYYAPDFELNVRASNMENSNSREYLDKITVAVIDNLRQTGPAPSVQMQDVPRKPFGGMTDEEEAELDDLDEDENKDVRMTEHRWDKHVENGAEFEASDDDEMAAANGATRSNGNKGTFNDFKSADAAEDSRSKSPREKQDDNTKEAVEAETHDVNDDTIEDVGAMEEQENQAAEQEEKEDQDLKKNKVDADGDVGMTYSSVADEATIKKEEGEPESVPEDEKEPEKPTEEKPSVAEPDKPAEAEGATEVKASDKPAVDQVSEEPVEKEGEAQATTEAETEPMEVDDKEKSEDKAEFPSSKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1I8</accession>
    <name>A0A7D5Z1I8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">hmp_0</name>
        <name evidence="19" type="ORF">G6M90_00g000830</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542985.1">
        <property type="nucleotide sequence ID" value="XM_014687499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1I8"/>
    <dbReference type="GeneID" id="26244358"/>
    <dbReference type="KEGG" id="mbrn:26244358"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="149"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI64089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="46190" checksum="C4FEC9464E749BDD" modified="2021-02-10" version="1">MALTAQQIATVKSTAPVVKQYGKTITTTFYKNMLSAHPELKNYFSLKNQQSGAQSAALANAVFAYAAYIDDLPKLSGAVERIAQKHASLFIKPDQYPIVGKYLVGAFAEVLGNALTPEIAEAWIAAYGQLADIFIQREKQLYSDAGAWQGWRPFKIAAKEVETDNIISVYLEPVDGKPLPAFRPGQYVSLQIPLPELDGLLQNRQFSLSVAPEEGMSQYRVSVKKEAIEPYTTEDLAEGRVSGIVCNRLHDRYQVGDVVNVSPPRGEFFFDDAAVSPTAPVVLLSAGVGATPLMSILDSIMKSSNAERPVTWAHAARHAHSVCFGKHIRDLAASARNVRSALFVKNIKDVDEEGRHYDFAGSMDIDKLAEEGALYLDDKTAEYYLCGPEEWMIKMRDELTSKGVHVDKVHLEVFRTGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1L2</accession>
    <name>A0A7D5Z1L2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g018850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548655.1">
        <property type="nucleotide sequence ID" value="XM_014693169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1L2"/>
    <dbReference type="GeneID" id="26238099"/>
    <dbReference type="KEGG" id="mbrn:26238099"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000040">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="320" mass="36253" checksum="AFEB75441934213E" modified="2021-02-10" version="1">MPSLPASVDLDECISRLYKKELLAESVIEAICAKTKELLMRESNVVHVRAPVTVVGDIHGQFFDLIEIFKIGGFCPDTNYLFLGDYVDRGMFSVETISLLVCLKLRYPNRVHLIRGNHESRGVTQSYGFYTECSRKYGNANVWHYFTDMFDFLTLSVVIDNQIFCVHGGLSPSIHSIDQIKIIDRFREIPHEGPMADLVWSDPDPERDEFSLSPRGAGYTFGAQVVKKFLAVNNMSHILRAHQLCQEGFQVLYDDRLSTVWSAPNYCYRCGNMASVLEVSDNGERFFNVFAAAPENDQHKDIQPGNEKVADGNALPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3C3</accession>
    <name>A0A7D5Z3C3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipid droplet-associated hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g048360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544951.1">
        <property type="nucleotide sequence ID" value="XM_014689465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3C3"/>
    <dbReference type="GeneID" id="26242292"/>
    <dbReference type="KEGG" id="mbrn:26242292"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37993" checksum="DDAFF5E1E6E5208F" modified="2021-02-10" version="1">MLSSIWKPSEQLRGAESRALIYFVCGNPGLIGFYVDFLDALRNLLDTSQSATAYDIYGRNLAGFCDHEHEPFTPDNPPFDVDGQVDAIYQDVASRRVSTEDGSGSGSGSDRPYDFVVLMGHSIGAYIAVEIFHRHMQDPGRAPHLRLRHGFLLFPTIASLALSQSGTRINYMRSLPTMETHFVTYAKALLGLFPQGTLRWIIQNAMGFSPPAADVTAEWLKSRDGVLQALHMGKSELDTIFEDKWDDELWEVSASAAELPAPRFFMFYGREDHWVANHVRDEFIERRRRAGEKGGRTSITVDEGNIQHAFCTKEHTSWTIARKVHAWVVEIDRAGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3L6</accession>
    <name>A0A7D5Z3L6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g039100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547265.2">
        <property type="nucleotide sequence ID" value="XM_014691779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3L6"/>
    <dbReference type="GeneID" id="26239828"/>
    <dbReference type="KEGG" id="mbrn:26239828"/>
    <dbReference type="OrthoDB" id="4941012at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25678" checksum="92150FB91B5CDA52" modified="2021-02-10" version="1">MIPLPWNQYKDIIISLYARHTLDEVVIMMDDNYHFKANARTYQKKFEEWGVGKRMNSRSRQLAIMPNGECVSTNSHRESDSDMMTASVDVAAASPSVYTEPGNLYPYMEVASYALDSELYQGGQGQYGYAMNMSDTAQFDVSQLLLSQIAEEHYPSTTTDQAGGTFASLPQAESEVQSAGYEPPSTAAAYQQVGLWPDNQSPRPESILRSHRWSRSHHRSSRSNRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3V1</accession>
    <name>A0A7D5Z3V1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g014600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549061.1">
        <property type="nucleotide sequence ID" value="XM_014693575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3V1"/>
    <dbReference type="GeneID" id="26238505"/>
    <dbReference type="KEGG" id="mbrn:26238505"/>
    <dbReference type="OrthoDB" id="5556956at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053030">
        <property type="entry name" value="Ribosomal_biogenesis_FAF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28096:SF1">
        <property type="entry name" value="PROTEIN FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33074" checksum="36A993470F853EA1" modified="2021-02-10" version="1">MAVLGKRKAPASSISEPDANELLRRHFEARFQPLEERLSNTKSEEQADEGDSDEDSEWGGLSNDDAAGSDEEEGDDAEDLLEGESGDDDTPAIEIIDHSTPQLPKESMSKRELKAFMSSRPPDQSATPNPIQPAVSSNPSTLPEDAPSLLKQDLELRRLLAESHLLAPHAAAKSLSSASSFAAQPKSFAAGRTRQKATDLRVQALGSKLSIHKQDKMPMHMRKGMAVAADAREAKRRREAKENGIILERETGKQRRTRGRRSDVDRPGVGRLRGAELRISERDVKRIEGNRDVFGRNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4F1</accession>
    <name>A0A7D5Z4F1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolyase ccsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccsE</name>
        <name evidence="3" type="ORF">G6M90_00g093100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541953.1">
        <property type="nucleotide sequence ID" value="XM_014686467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4F1"/>
    <dbReference type="GeneID" id="26245421"/>
    <dbReference type="KEGG" id="mbrn:26245421"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF13">
        <property type="entry name" value="ALPHA_BETA HYDROLASE PSOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="435" mass="47835" checksum="D3E8DE976C9BE3A9" modified="2021-02-10" version="1">MHKLFPGSGFFDFEAIRILGTTVYGGADVAEVLEAVGEIKPGDPVSWERAWRTQALRAEELADEAHRHGDRDAARRGYLRAANYTRASGYMYVSTSTGNGESLAQDACSVAEKVRTLFRKALPLMDGQVHRLSIPYDEYHLPGYLYLPPVDRKIKGRKTPILVNCGGADSCQEELYFLNPAAGPGMGYAVLTFDGPGQGLMLKQYEVTMRPDWETVVAQVIDYLVKFSSQHPELDLDLDSIAVSGASMGGYFALRAAAEPRVKACISIDPFYDMWDFGTAHVSPIFISAWTKGWIGHGFVDRMIGWLSAVSFQLKCEISITSTLFGLSSPAGILQHIKKYTFASGSEDGTSFLSHVTCPVLVSGAGKSLYMDVDNHTRRCFEALTNVPPQNKEIWVPESDGQGSLQAKMGALALCNQRTYQFLDKAFGIIRDPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4J6</accession>
    <name>A0A7D5Z4J6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g067260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539265.2">
        <property type="nucleotide sequence ID" value="XM_014683779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4J6"/>
    <dbReference type="GeneID" id="26247939"/>
    <dbReference type="KEGG" id="mbrn:26247939"/>
    <dbReference type="OrthoDB" id="5370830at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="36818" checksum="4DD7D5F53FBF5563" modified="2021-02-10" version="1">MAVDLIAGPFVPSLIPTPFPLSSLPKRQPPALSAQVPALPTQRPSLVSAWPASSPHAVRRAPVPNPQIDGMRIPSLAATGLSLSLPRLGGHSNSDSDCGSACVTPKREDTSTIWATPHDSYSSSIGVPGCKIDTNRVAYWPQSVDCDNICVSLEYDHRRVYLLRIDQSTGAHDVSYDAWNYLYTGKSATEKPTAGGPVAMQYRNVDASRCKSLIHTKDNKLPLSAANSMNFLAGCLAQPDSWVANNYMTLNIVDSICTLGVDEQCKLHWPDANQPSCPHVLGGQVSLKGAPVYNIQYPSGKKVLASSGLPSAGGGDEDNAAGRARCPWVLLAWCIVVFLSCYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z512</accession>
    <name>A0A7D5Z512_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g062460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542633.1">
        <property type="nucleotide sequence ID" value="XM_014687147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z512"/>
    <dbReference type="GeneID" id="26244582"/>
    <dbReference type="KEGG" id="mbrn:26244582"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="143" mass="15459" checksum="FD3A5DF9EAF04F20" modified="2021-02-10" version="1">MSLLVLGVLIQRRVRLFCFAHCCEMAVCDGFDFSAIRALSQRPDFSFRSNRLSSPVHRLFLIFGLERGISNSSRSRITPGLARSPLSAAGSSSSLLSLSLGVLSRIEIVTANFTVAGTLSHATFSRRDMECIVVLGASSGALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5G2</accession>
    <name>A0A7D5Z5G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g045660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544694.1">
        <property type="nucleotide sequence ID" value="XM_014689208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5G2"/>
    <dbReference type="GeneID" id="26242035"/>
    <dbReference type="KEGG" id="mbrn:26242035"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="548" mass="61270" checksum="4650561A27A8EB2A" modified="2021-02-10" version="1">MGADINVDVLVIGMGPTGLGAAKRLNQINGPSWLIVDSSDKAGGLAGTDTTDEGFLYDVGGHVIFSHYKYFDDCLDEALPKDDDWYTHQRISYVRYKGLWVPYPFQNNISILPKEDQVKAIDGLIDAAMECRVANTKPKDFDQWILRMQGEGIADMFMRPYNYKVWAVPTTKMQCEWLGERVAAPDIKTVTKNVILNKVAGNWGPNATFRFPARDGTGGIWIAVADTLPKEKKRFGKQGEVTRIDAENKVVHFADGTTIGYGKLVNTMAVDHLAEKMGNQELMSLTKQLFYSTTHVVGVGIRGERPERIGDKCWLYFPEDNCPFYRATIFSNYSPYNQPQKDAKLPTLYLADGTKTSSEAKEGPYWSIMLEVSQSSMKPVDVENLLKDSIQGLINTEMLKPEDEIVSTYHRAFDHGYPTPSLEREGVLKQVLPKLQDMDILSRGRFGSWRYEVGNQDHSFMLGVEAVDHIVNGAVELTLNYPDFVNTRRNEERRLAQSFNFASSALTNGTKVTTNGVTNGTDLPSRERASSKVSVNGGHSRKSSKQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5J3</accession>
    <name>A0A7D5Z5J3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547807.1">
        <property type="nucleotide sequence ID" value="XM_014692321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5J3"/>
    <dbReference type="GeneID" id="26240370"/>
    <dbReference type="KEGG" id="mbrn:26240370"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55445" checksum="0079831438F8D268" modified="2021-02-10" version="1">MLPPSVAKIARRSPALTRAASTATAQKAVKKEGDISDAFVSLSGARRPPLPDRFRKLKCDLVRGRERQIADSWTRLLRRLRAENEIIAQKGSDVIPQVNFADLEAGCEGLKEEIRKRGAIVVRGVVPEGEARAYKEEIEDYVNKNPWTRAFPADNPQVYELYWSTPQLKARSHPSLLQVQHRLMSLLWHTSSDQAQISLQNPLSYADRLRIRQPGDATFALGPHIDGGSVERWERNGYGLGGVYDRILQGDWEKYDPWDASGRVQAVNNLYDGLGACTMFRMWQGWMSMSESGPREGTLLVNPLMHMATAYVLLRPFFAPLNESKTSTGFLDESNWKLISEADMSSELQGASPGHGQELTDELHPHLELERTMVHVPKIKPGDFVAWHCDTIHSVDKVHGGRGDSSVMYIPVCPVTDINAAYIARQRQAFRDGTPGPDFPGGEGESRHVGRPTEDMLRSWTNGIGRQAFGLDKIEVRDGASPGEREVVERANVTLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5M7</accession>
    <name>A0A7D5Z5M7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ xdj1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">xdj1</name>
        <name evidence="10" type="ORF">G6M90_00g041980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547538.1">
        <property type="nucleotide sequence ID" value="XM_014692052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5M7"/>
    <dbReference type="GeneID" id="26240101"/>
    <dbReference type="KEGG" id="mbrn:26240101"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
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        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="46746" checksum="7BADABBE47D8EBB2" modified="2021-02-10" version="1">MSGAMGEEEIDLYGLLSIERDATQDQVKKAYRQAALKYHPDKVPVEQREESEAKFKEITRAYEILSDEQKRHLYDAHGMAAFDPSRGGGPGGPEVDLNDILSQMFGFNMGGPGGPKRPRRGPDEEQEYKVTLEELYKGKTVKFAANKQVVCSQCKGSGGKEKAKSTTCERCKGNGMVEAIRQIGPGMMRRETVLCDHCQGAGQVFKEKDRCRKCKGKRTMQEKKALEIYIPRGSMQGERIVLEGEADQYPDQIPGDIVFTLVEEHHDTFSRLGNDLSAELTVTLAEALTGFSRVVLKHLDGRGIHIERPRDKILRPGDCLKIAGEGMPMKRGEVKGDLYLLVTVEFPEDGWLKDDASYEALQKMLPPPPPPIEAEEVDELEYEDGADIEKMGENSGDPRFASEWGDEDEDDGQPQCQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6A2</accession>
    <name>A0A7D5Z6A2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g062390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542639.1">
        <property type="nucleotide sequence ID" value="XM_014687153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6A2"/>
    <dbReference type="GeneID" id="26244588"/>
    <dbReference type="KEGG" id="mbrn:26244588"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028897032" description="Peptidase A1 domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="820" mass="85964" checksum="F3FC5F244D9D09BD" modified="2021-02-10" version="1">MLSSLFSLAALPLATQALLEFPMDNRMVQEPGLIRFPLDIAAGAPTKNRMLRRQNEIGVNAEKSGFFYSIELQVGTPAQAVRVNFDTGSAELWINPVCSKSTDPGFCDKLGRFNGSQTFVDTNTTHEIRYGTGFAKLEYGYDYVQIGSAKISQQMFGVATDSEFASAGILGAAPQLKGWKSDYPLVLDNMAAQGFIKSRAFSLDIRTLASKRGSVVFGGIDTKKFSGHLEKRPIIPAAESPDKLTRYWIYLDGVSVTKEDGSKVVIFDQANGQPVLLDSGYTVSALPTKHFNKIKDAFPGASAPPEGDKSGLYRVPCDVGSKNGSVNFKFGKTEIVVPYDDFIWKQPDNNLCVLGVTPDDEFPVLGDTFLRGAYAVYDQDNRNIHLANNEDCGSSLLAIGTGPDAVPSVEGDCGRPKPTTTSTHSKTTSAPIPTGHNSTISSTQSTPSSSSVASPTSTHSRTTSAAIPTAHGSTVITSAKPTASSSSTPSLTIPTAKNSTVISAKPTTTSTLVPTSHNNNNNNTILNTSKLISTTSKLISITSNTPPTGTEQITTVPVTYTSTFTTTSVHTITSCPPYVTGCPIGSVTTETITGVTTWCPDNTTPSAKPPQTTETKPPPTTVITAQPTITSAPSITSVFTTIKTHTITSCPGQASCSKGHVTTEVITSTTYLCPESTATFTIPRTHTCREGDSECKPGDTVTTVFTVTVEPQTTADQPTPVPGCGDNCVLPPPAQTQPPAETTAAETQPGITAVVTAPGSVPTTVSGTNGTITTVTKPSDTPCSTCSPETTSPPLTGGASGSRVPIMAVAIIVGALAVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6F5</accession>
    <name>A0A7D5Z6F5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g093690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987587.1">
        <property type="nucleotide sequence ID" value="XM_066131457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6F5"/>
    <dbReference type="GeneID" id="90968140"/>
    <dbReference type="KEGG" id="mbrn:90968140"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase (KR)" evidence="3">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17771" checksum="6ECF2D4A3500DDE5" modified="2021-02-10" version="1">MSPSMEVISSLSTQKKFSSPSQSHVTYFPASDLRGIFDHLHRLKKTEHLHVKFDNMDTVQTNVHLFVRPTQILDSTGTFLIAGGFGGLGRAIARWMVSRGARSLILLSRSGPKNNPNAVVLLDELRARQIKFQNPRCDATNREKLLQKIARQQALAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6K0</accession>
    <name>A0A7D5Z6K0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g040370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986583.1">
        <property type="nucleotide sequence ID" value="XM_066130269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6K0"/>
    <dbReference type="GeneID" id="90967664"/>
    <dbReference type="KEGG" id="mbrn:90967664"/>
    <dbReference type="OrthoDB" id="10377668at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5846" checksum="F0BC9BA2B4B73280" modified="2021-02-10" version="1">MHLGRDDMQLEASRPPDDSPILSRDTRDGKTRDDAKAPRLAIYAGKHGRQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6U1</accession>
    <name>A0A7D5Z6U1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C-module-binding factor A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbfA</name>
        <name evidence="7" type="ORF">G6M90_00g072800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545782.2">
        <property type="nucleotide sequence ID" value="XM_014690296.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26241815"/>
    <dbReference type="KEGG" id="mbrn:26241815"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF195">
        <property type="entry name" value="ACID PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="171"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1080"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1227"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1567" mass="175783" checksum="9E992B27C737521C" modified="2021-02-10" version="1">MPTSLHPQAKFDPIPPDLDLYGLVDRTPNFKWVQRVSRSQVLGLGQQGFEKLIQIHVIAGGKPLVIDGWDALFPEELFNVNWLEKTYDKKEENVRDVTAGTDIPMTTGHYLRSMKQLTNQWTPQNFRDERRQRLYLKDIDCPVEWRYELQTILHPNLFYLNDNVTKSGSSNPTRRPGGDGQHGENSIAPAGDLMSSLPEEMRAENLMCYVGHEGTYTPAHREMCASVGHNIMVETSGDSPGEKPGSSIWFMTESKDRDVVREYFLSMLGHDIEIEKHFAQINAWKKAPFDVYLVDQRAGDFIIIPPLAAHQVWNRGTRTMKVAWNRTTPETLRLALREALPKARLVCRDEQYKNKAIIYFTLHKYYQLLKEMERQEDITQNSFMGIGRDIVRNSPRARQLAGDFRSLFSLFTEILIDEAFAYNEKQVERLPFDSCVTCSYCRCNIFNRFLTCKNCTRVLVNGDEDAYDICMECYAMGRSCACLSGLQWCEQWSWSELSGKYELWREMVIVNDGFVDLHSSPPPFETARQKSAKKSVAQICQEALIRRPWKDITKQDVGKVASDSEQGDVEDEPKKKTKRKQKKGEVRRCHVCCHKDYSYRVHECSNSECAEAYCYGVLYRAFDMMPQAVLQNETWQCPKCLGICNCGYCRRAGNTNPYTPKNTSLGHDTRPIADDRSVEALVDFRVHNLSWLKAAGEESRSRDSRRMQILRQQADHAKARSELAEVESERALLGDGDNSQRATNTDPEGRDPERQSAHEYPTLALESENSSRLRSDSAGPPVAHNGISPYPDPSVASNYGIGMGYYEQDDTPDKILFDPYKAPSPSAIHLADLEVPDSVKKSIRAAKSKAKRENEDPDFIVGRSSHKRSRHTNGIDILDNLDPALFDVEPSTASSMLRQRRLPSSNTIRHPAENQDGNLETLSTEPVTETMPTEPILRHARPLASYVEVDDVDMDEVEEGEMVGEGSGQEAFLDDKAAKAIEEARLSEVQNSGLQQEASVTSKHLESTQGRKSRVRPLQVSLRSVDSVSMTDPISPRPAIRRRGRPRKSTVVSLKQSDTAADGTAGALRDQGESLGEAPDTSNVRSSNYQQLKSNSSIGASLQQHEEPSVRSVATVGISQERNLKDIGRELRSNPRGRESQPEAKNPASQVRNLKSASQPFMSMAERLALKGRKFKIGKRRAAASPLLKDKDGGPHVSEASESTIRESRQVLSAVAGRTEDDEQESVSKSSDISTTRKTVVRLSDMVSSEDEHGSTIDMAVSSSDDSGDSDIPASGMNSRERASTELGYTQSQTQLNNLTSALASNGVYGFIFNSSNTPQRDYGAYNWCNMPHVRPTEYVVADKAYELQYVELIHRHHKRTPYASNAFPVESYQWNCEDAHLFLYGEPLQGKQSSPVFRKGHISPMNPFVPPGWIGSCNFPQITSGGLSDSWHHGADLYAVYHDLLGFLPSRNSDYKSSVRYRVTNNVITSQVAGMVVSGMWWTNDPYPLIVEISFTSHDYPASISVLVTAPSTIAYLVYLLTLLLTKAVVPRPQESTAWNHNTLVIQPIHSSMASNPTKILIGNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7U6</accession>
    <name>A0A7D5Z7U6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable dipeptidyl-aminopeptidase B</fullName>
            <ecNumber evidence="6">3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Dipeptidyl peptidase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">G6M90_00g065010</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="6"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540043.1">
        <property type="nucleotide sequence ID" value="XM_014684557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7U6"/>
    <dbReference type="GeneID" id="26247079"/>
    <dbReference type="KEGG" id="mbrn:26247079"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF162">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12 17" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028978229" description="Probable dipeptidyl-aminopeptidase B" evidence="17">
        <location>
            <begin position="23"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="19">
        <location>
            <begin position="108"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="18">
        <location>
            <begin position="563"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI68829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="786" mass="88340" checksum="DFC79C6FFC14CC72" modified="2021-02-10" version="1">MGIISFRKLVGVLPLLAVVGLAINPPRKPQQPTGNGDRLLTYNETTPYARHNPSRMSVRWVSSVDDGQYITTNENSDLVLVDIVSEKETTFLPAKSKPKNLHAFWIRHDRQAVLAAANFTKQYRHSYLADYFVVDVNSGNNTPIVDDQAGDIQYATMAPVGETIAFVRGNDVYLRDEHGQIHRITDNGSADIFNGVPDWVYEEDVFGNRLALWYSPDAKFIAFLSFNDTGVGTFTIPYYMAGQEKAPSYPQELELRYPKAGTTNPTVELNIVDVETKKLINVPIDAFSKNNTIVGEVKWVTDKHSALIYRAFNRVQDRDKHVLVDVQTMASKTVRERDGTDGWLDNHMAISYVGEAQDSGNNYYIDLSDDSGWTHIYLFPVNGGDPVQLTSGDWEVSTILAVDTSRKLIYFESTKHHSTERHIYSVSYTTLEITPLVNDTVPAVWSASFSPQGKYYILSYNGPDVPYQELYASNNTDAPLRTLTSNDEFYKLISEYNLPNVTYFELQHPDGFSLNVKQQLPPNFDPTKKYPVLFTPYGGPTSQSVTKRFQPLDWSAYIASEPELQYVVYTIDNRGTGYKGRRFRSSVVKYVGNLEAQDQIWAAQELVSRNEFLNPHKVGIWGWSFGGFLAAKVIEADSGAFTFGLSTAPVSDWRFYDSAYTERYMKTPATNADGYNKTAIRNAEGFKNVAGKFALMHGTGDDNVHYQHAAVLADLLVAKGVSPDKFQMVAFTDSDHGISFHGASEWIYKFLTAKLWEEVERKDGSLVHQWSRRRLVVGEGTKGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z876</accession>
    <name>A0A7D5Z876_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Microsomal glutathione S-transferase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g066720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539277.1">
        <property type="nucleotide sequence ID" value="XM_014683791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z876"/>
    <dbReference type="GeneID" id="26247935"/>
    <dbReference type="KEGG" id="mbrn:26247935"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF2">
        <property type="entry name" value="MAPEG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18381" checksum="4BB0BD9EF15D7BE3" modified="2021-02-10" version="1">MSSLASILGFGSSSEPRDMVATYLIVNALWSHTLSSTRALKMLYKMDNHVSPRTDLDKFGPRAVLEGKITQAQLDMLKRNEAAHANSMEHFPIFATALILAKLAGLPAADINSAGFAYTVLRVAFVGNYVLSITMGWAALRPVFWWASNIVCFRLIWRAGKMFNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9U5</accession>
    <name>A0A7D5Z9U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cnb-1</name>
        <name evidence="11" type="ORF">G6M90_00g096410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987665.1">
        <property type="nucleotide sequence ID" value="XM_066131510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9U5"/>
    <dbReference type="GeneID" id="26241116"/>
    <dbReference type="KEGG" id="mbrn:26241116"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20728" checksum="853909AAE646A05B" modified="2021-02-10" version="1">MGNTTSQVLDNIVQGSNFDREEVDRLRKRFMKLDKVHIPPLFLADNSGTIERDEFLSLPQISSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLQFAFKVYDIDRDGYISNGELFIVLKMMVGSNLKDQQLQQIVDKTIMEADLDNDGKISFEEFTKMVENTDVSMSMTLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9Y2</accession>
    <name>A0A7D5Z9Y2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g099230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546423.1">
        <property type="nucleotide sequence ID" value="XM_014690937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9Y2"/>
    <dbReference type="GeneID" id="26240846"/>
    <dbReference type="KEGG" id="mbrn:26240846"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12195" checksum="F5FEC61B14D7B122" modified="2021-02-10" version="1">MFVTNRLLQACRITLFTRDNCGLCTQAKGVLSDVWDKRPFAYKEVNLALPESRSWMEFYDFDIPVIHISKVNAAEEQVNAAGKAVKLMHRFTVEQVEAKMDQVEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA60</accession>
    <name>A0A7D5ZA60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g102760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546072.1">
        <property type="nucleotide sequence ID" value="XM_014690586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA60"/>
    <dbReference type="GeneID" id="26240495"/>
    <dbReference type="KEGG" id="mbrn:26240495"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000064">
        <property type="entry name" value="Probable acid phosphatase Pho610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF15">
        <property type="entry name" value="ACID PHOSPHATASE PHOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028873232" description="Acid phosphatase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="47597" checksum="7E5BAA22B84D69B7" modified="2021-02-10" version="1">MLLQISASFLAVASVVSATPCKSQDGWETRYTATGTADVAKAAATAKTSSPTSHVKGKAFDRLAIIYFENQNYDKSFGDPNFNWFTKKGITLSNYFAVTHPSEPNYMASIAGDYFGMENDAFTRSPRNISTVIDLLDTKGISWGHYQEDMPFSGFEGNAYRNQKNGANDYVRKHNPAVLHDSITHSEKKLSQIKNLSLIDTSRSMFHKDLKDNKLPQWMFITPNMTSDGHDTSVTVAGVWCRKFLEPLLEDKNFMQNTLVLVTWDENESYAARNNILGILLGDAVPKELVGTEDKNFYNHYSEIATVSANWDLPTLGRWDVGANVFKVVADKTGDKLRQWRSQEQLQSMYWNYSYAGQYNDQGGNKIFPKPNLDLDKAYNGRPILQSVKDTWKNSKAPTYYEDTIETPDGLHPPEGYEPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAB8</accession>
    <name>A0A7D5ZAB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ML-236A carboxylate methylbutanoyltransferase mlcH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mlcH_1</name>
        <name evidence="2" type="ORF">G6M90_00g111570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543708.1">
        <property type="nucleotide sequence ID" value="XM_014688222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAB8"/>
    <dbReference type="GeneID" id="26243095"/>
    <dbReference type="KEGG" id="mbrn:26243095"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="16"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="414" mass="45857" checksum="FFAC02809C041CE3" modified="2021-02-10" version="1">MSFSDEIEQKLSATIDKAVAGEDAIPGTTVVIFAKDGSELFVKSAGKRGVSTNEPMTPDSIFWLASCTKILTGLACMQLVERGVLKLDDATQTEGFCPEWRDLKVLTPTGELVEKKNAITLRMLLTHTAGFGYSFFSDRLRDWGYPAGIEEFSGDMADIMQPLLFQPGEGWQYGVNMDWAGVILERATGKKLNEYIQENICKPLGLEQLTMFPTEQMKKHLVYMHQRAPDGKLSRRDHLQRRNLTATTAEQQKAIFNSGGAGMFAKPQEYCRVLAALLNDGTCPRTGVKILEKSTVDEMFTNQIPQFPQFGRQGFPASKPELVNPVTDIYPTPGNPPQGWGLTFMLNGGPTGRSDTTGWWAGIANVFFWADRENGIGGMVCSQILPFGDPRVLGLWVELESLAYQGLKMMTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB82</accession>
    <name>A0A7D5ZB82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g097050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546634.1">
        <property type="nucleotide sequence ID" value="XM_014691148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZB82"/>
    <dbReference type="GeneID" id="26241057"/>
    <dbReference type="KEGG" id="mbrn:26241057"/>
    <dbReference type="OrthoDB" id="5368516at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="548" mass="59988" checksum="80D418A4F974DEB1" modified="2021-02-10" version="1">MTAKRKDFSFRLKSSFWKVLGPAEVFPFVLSLGIVVQGIIFASIQSFGLRGLFIRGCEPLSQVMLPAFFIVPYIQFTFGLEAIVQALRPYQPFSPRSKWSVPTCLAVIVFGLILTFVLTRLELPPDICFPSVVFFLRRWAIGCFGLLIGIAATLLIGCVVTFIRLYRVLGIGEQQRITATWMAWFMALGVLTLSIMLPFFYAVAVDDSSTIKTSQSELSMATVVVSNLTGLMTGGMYILLRSTKIGKLGPKGYFEFDRQRSIRHPKSSVPHSFIFTRQMEQPVPLSTQLPPARRQASSLYATQDVELGLGPVHALTSDESQKPDGMPEAPAVGVATTTPGPVPSQEAHARKNSAYNLFPRDTISDKPMYTLPATAYVSSSKDNDQAVNPFDDDELLPPPTIRLSGGRHNRESSLGSSATVPIGIRVSNIHDMPSVQSYYEVPPSPRATTPTRPVSSVPVPQIPDTLVVPEDEASEGGDKQLPPVPLALVNKEPVKEVDEEEVRLSPTVYTPQRTPSKTKAKPSSPTAQSVGPPHSPESFSPVNEAEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCG2</accession>
    <name>A0A7D5ZCG2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Demethylsterigmatocystin 6-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aflO_1</name>
        <name evidence="7" type="ORF">G6M90_00g111130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987983.1">
        <property type="nucleotide sequence ID" value="XM_066131822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCG2"/>
    <dbReference type="GeneID" id="26243136"/>
    <dbReference type="KEGG" id="mbrn:26243136"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="220"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="383" mass="42839" checksum="AF4D0C19B7350DD1" modified="2021-02-10" version="1">MYTLLTKAKNFLEATINAGQRKVLGALRKLSQALESPQDSAQRIMYLQIQIALVRIGCDLRLFDILAESPTPLSVDVLSQKTGAAPTLLGRVLRYLSSHGVIKEIGKNTFTNNKITKTFTYPGFRGGIYHYHDNVGPAIQALPDFLKENKYQDITSAVDTPLQKAWNTDLPAFIWVQSKPENFTHFNQFMAGGRLGMPTWLDAYPYKEKTKGLKTEQPFFIDVGGGIGHQAVALREKLPELPNKIILQDIPATLEHAIKHPGIEIVAQDLFEPQTITNARIYYMRNIIHDYPDDKAIVILKNTITAMAPDSVILIDDMVLPDCGVPWQATQIDLVMMSTLASQERTHEQWFSLLSKAGLKINKIYTYTASLQDGIIEAVPALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZEA4</accession>
    <name>A0A7D5ZEA4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Carboxypeptidase M14A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">G6M90_00g106300</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539620.1">
        <property type="nucleotide sequence ID" value="XM_014684134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZEA4"/>
    <dbReference type="GeneID" id="26247617"/>
    <dbReference type="KEGG" id="mbrn:26247617"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028830291" description="Carboxypeptidase M14A" evidence="18">
        <location>
            <begin position="17"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="19">
        <location>
            <begin position="117"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="17">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI74449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="46191" checksum="073BE197B824605E" modified="2021-02-10" version="1">MKALAVLSSLLAPAAAVAIDSELSYDGHRVFRVRVADDGSHVQSVIDKLQLTTWQPPSRKGAFADIQVAPRQLEEFHKAMDGQDVTTMHDDLGKSIKREGTFMTYAAGSANDTWFTSYHSYDDHVRWLNDLGAKFSKNAKTVTSGTTLEGNPITGLHIFGSSGGGKKPAVVFHGTVHAREWIASMVVEYMTNELITKYGSDKDITAFVDKYDFYMFPIVNVDGFKYTQTTNRMWRKNRQTTRGSNCLGHDINRNWPYKWDGQGASTNPCAEDFKGESEGDAPETKALSQFIQGVKDAQGLKLYIDWHSYSQLFLTPYGYSCDAKAPNDAEIQSLARGTVDAIFAVHQVRFNSGPICQTIYQASGSSIDFVADVVKGDYSFAAELRDTGKNGFVLPAEQIVPSGEEAFAGVKYLLQNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPM3</accession>
    <name>A0A7D5UPM3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">mus-51</name>
        <name evidence="23" type="ORF">G6M90_00g007080</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549802.1">
        <property type="nucleotide sequence ID" value="XM_014694316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPM3"/>
    <dbReference type="GeneID" id="26239246"/>
    <dbReference type="KEGG" id="mbrn:26239246"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="22">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="552"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity" evidence="20">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR003033-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QLI63559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="646" mass="71655" checksum="A6D6249B1AD271BE" modified="2021-02-10" version="1">MAENGQDWKREDEDDGDQEIDETTYKAQKDAIIMAIEVSDSMLKPPPPSDSKKADQDSALEAALKCAYHLMEQRIISNPKGMMGILLFGTKKTKFYDDEDGRNGLGYPNCYLFTDLDIPAADDVKVLKNLVEDGEDDDEVLTPSSDRAIMSNVLFCANQIFTTKAANFGSRRLFIITDNDNPHPSDKAAMSAAAVRAKDLYDLGVTIDLFPITRGDSKFDLSKFYDDIVYRDPIAEANSTAVAISKSGDGLSLLSSLTSNINSKQTPKRAMFSNLPFEIAPGLRISVKGYNVLHRQTPARTCYIWLDGEKPQIAAGETTRLAEDSIRTVEKGEMKKAYKFGGEYVCFTPDEQKSLRDFGPPVIRIIGFKPRKLLSMWASVKKSTFIFPSEEDFVGSTRVFTALWQKLIKDNKIGIAWCIVRSNAQPTLAAIVPSREPSDEKSGTPYLPAGLWIYPLPFADDLREIKPPDGVTQSSDELKTQMRTIVQQLQLPKAMYNPLKYPNPALQWHYKILKALALEEEVPETAEDATKPKYKAISKRAGGYLEEWSEKLEEDAGTARTSKSLKREADDESSDRPAKQRRGASSGQLNPSSMSVAELKEAITSGAIMKMTVSQLRDVAGSKGLSTAGKKAELAERIEQWVDDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ64</accession>
    <name>A0A7D5UQ64_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANK2_1</name>
        <name evidence="5" type="ORF">G6M90_00g011700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549352.1">
        <property type="nucleotide sequence ID" value="XM_014693866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ64"/>
    <dbReference type="GeneID" id="26238796"/>
    <dbReference type="KEGG" id="mbrn:26238796"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
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        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        </location>
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    <feature type="repeat" description="ANK" evidence="3">
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            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
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            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
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        <location>
            <begin position="624"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="690"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="925" mass="101088" checksum="F4CC2ADB3D78D5BE" modified="2021-02-10" version="1">MDPLTIIGAVAACSDIIKIIVRITSNLSQVRSRWAEGGRPVQLLAQKLSTIRAALTEIETWAEFSLRSNPRGESLSQWFKIAIDGCQAVMQALDQDILALVGDSVGSRLRQFFLDTNSSLKEHDARLQSQISALQLLLTAAYCQNLSEQNDLLRKHKSTQLLQRVQEDITTIREQSTVRETASEQPNPHPQDDAQNTEIPSHEGISDQIPLISNLPVLNYPTEEWQRPLPFQRPEYADSSIPSEKTSQTLSIFSKRPRSASTGTSDGSGGQHTSWLVRRLSRTARPKSAGRISREQLLSPISRKRIKAPGDLAPTEIYLQSHNNTPPPRTIVAAQRGDVAEMTSLIRRRANVEQIHPKTGRTPLAVAAHCGHEGVVELLLAEGCNLGTKDRSQLEPLHLAAANGHCQVIDILLDREADVNVRGPEDKTPLRVACDHGQMNAIKTLVRRQALVDARDRKKRTSLHMVSDSGDNDVVRLLLQSGANKDAKDSQMRSPLHCACAAGRLDVVRTLLEAKANIEAQDDAKMTPLGIASKLGLRSVAGILIQNKALTNIKSQGDMTPLHWASFQGHDEVVELLLKQKRAETEARNENNRTALHLAAMTRSFGVIEKLLRAGANMEAECSQKYRPLHYACKDVEYSEASLLLNFGADFNAKTSTGETPLHLATKAGSKATVCKLIERGASVDCQDGQGTRPLLTACSQGSMMIVQKLLDSGARLNVPLGPGLRSDSPVCRAASGGFVPIIQELINRGASAREIDSGGWQPLRHAAFMGHVSAVGCLLGNGARANDLGPLEILSFASTATLDQMTRILEILETGLRSEQAEHQRVVYLEASATPANPGDPLELHSNPSSTPELVRNGSYMGNRRLFDEESEGVAHGTVSLANNLQTQHRYRETRPPDGVLQSDSEYSSSYRPEDTPRSLSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQG7</accession>
    <name>A0A7D5UQG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain-containing protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gpatch11</name>
        <name evidence="3" type="ORF">G6M90_00g012210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="79"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="211"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26239038"/>
    <dbReference type="OrthoDB" id="5288142at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="790"/>
            <end position="884"/>
        </location>
    </feature>
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        <location>
            <begin position="1029"/>
            <end position="1186"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
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        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
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        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
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            <begin position="866"/>
            <end position="877"/>
        </location>
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            <begin position="1029"/>
            <end position="1040"/>
        </location>
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            <end position="1053"/>
        </location>
    </feature>
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            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1125"/>
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        </location>
    </feature>
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        <location>
            <begin position="1164"/>
            <end position="1186"/>
        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI64731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URS6</accession>
    <name>A0A7D5URS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxynicotinate 3-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nicC</name>
        <name evidence="7" type="ORF">G6M90_00g006380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="26239313"/>
    <dbReference type="KEGG" id="mbrn:26239313"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="364"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI65334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URV6</accession>
    <name>A0A7D5URV6_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">AGA1 A-agglutinin anchor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g013850</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549137.1">
        <property type="nucleotide sequence ID" value="XM_014693651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URV6"/>
    <dbReference type="GeneID" id="26238581"/>
    <dbReference type="KEGG" id="mbrn:26238581"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="52432" checksum="0072543DCB981043" modified="2021-02-10" version="1">MSSLQRTRSLRKPTIPPPAEKPVRPTATDATRSGSPSRLPLKPFARPPTTILPGSSATNTTTAASSRSSRPAPTSLARSSSLSTRANGASAQETAKKETSRYPPASGANRAAARTRPTSAGSGSAEPARRPPTHVRAKSTATSLPPATSLPPPSSGRVGSQTTAARGGHGRHVSMSVDNKGPSTPAKPSVAPPAAVAKAQAQPRLRPAFSTLQQHYSPAKSQAPKPLTSAIIAPPSPSKLPANIAASAETSRLQAELLQLHLLHRDSGAVQAQWHASAEAKLGARFEELGRESGRVSERERFAAESDNILALRRWARGGRYGIEDKIQSLDEILTGLWTLSEPAGRYARVVKRFERWADHMCDAEEARHDIGRMLVHGHDSLFVGELDATWREECAGLTRRLETWRARLAEIDDLPTQEGVATAEASSLGRMLAGAGNLVHDMLTELHAMQEIEQQALAREDEWIERVNREGDDDIDTPRAGAVWRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URY5</accession>
    <name>A0A7D5URY5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplA</name>
        <name evidence="4" type="ORF">G6M90_00g020150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548529.1">
        <property type="nucleotide sequence ID" value="XM_014693043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URY5"/>
    <dbReference type="GeneID" id="26237973"/>
    <dbReference type="KEGG" id="mbrn:26237973"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="289" mass="31628" checksum="046D6C34636BCD16" modified="2021-02-10" version="1">MARLSIAQVTRPSTTSIPKFLAPAFVQTRQASVVRIKKVKKKRAIPKDFKRHNLEKRQFPQFSLCEAMRVLRAVEVGQPPASIKYEVHINLKTARNGPVVKNSIRLPHPVQSDWQIAVICPEGSDIATAATAAGAVAVGEETLFEAIRKEKIDFDRLICHEASEKALNKAGLGKILGPKGLMPSKRMKTIVSDVTKSIRDSAGAADYRERQGVIRMAIGQLGYTPDQLKVNIQALLKKVKSECAEISEEVSKEVHEVILSTTNGPSLSLNGKFNDVEGETQPEALAGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTB5</accession>
    <name>A0A7D5UTB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">INM2</name>
        <name evidence="9" type="ORF">G6M90_00g007350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549775.1">
        <property type="nucleotide sequence ID" value="XM_014694289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTB5"/>
    <dbReference type="GeneID" id="26239219"/>
    <dbReference type="KEGG" id="mbrn:26239219"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="297" mass="31837" checksum="DF0F7E429501DFC4" modified="2021-02-10" version="1">MADLDLQAVHDEMVAIAYEAGRMILSANPADLDTGTKLNSVDIVTEADQAVEKMVSGRLAASFPSVSFMGEETYKPGMRLGPEPTFVVDPIDGTTNFVHSFPNACISLGLAVQRSPVVGVIYNPWQDLLFTAIKGKGAYMTRSKGTTPQKLPLAKSPRPLQGLGTSLIAVEWGSDREGSNFELKTDVFKKLAASRESGGSMVHSLRSLGSAALNIAAVAAGQMDAYWEGGCWAWDVCAGWCLLAEAGGRMVSGNPGNWDPELESRVYLAVRGAPTGQKDLVEEFWKVIGDRKMGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTQ2</accession>
    <name>A0A7D5UTQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g033220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543251.1">
        <property type="nucleotide sequence ID" value="XM_014687765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTQ2"/>
    <dbReference type="GeneID" id="26244052"/>
    <dbReference type="KEGG" id="mbrn:26244052"/>
    <dbReference type="OrthoDB" id="4570620at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="394" mass="42943" checksum="01306D17FD18A500" modified="2021-02-10" version="1">MPPGAERGMDASAIDFDALIVGGGPAGLAALSALGRVRRTALLIDSGEYRNSPTRRIHDVAGFDGVTAAYFRWSARQQILHYKTVDAVNGTVTSIRPKANNTYFIATVETAEGSASTYTARKIIIATGVRDLLPPTPGLRENFGKGIYWCPWCDGHEHADQPMGILGPFDKTVEAVAEASNLNSDIIIFANGTDTYENRVRADAAFAENSSAYLDRRHVKVDNRTVTRITRLRDGEDLNRDPSLPTSPEYDLFNIEFDTGSPVERGVLLTAFTYEQRSSIGAKLGLNTKDDKLVVDEDMRTSVPGVYAVGDANSDIRTNILHALHSGKSAAVHLHTEIERELSRSLTSASGFRHGISRPSEERRNHGDGFSSKLNDVELPDSGTQVALSRLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU76</accession>
    <name>A0A7D5UU76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g043810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547717.2">
        <property type="nucleotide sequence ID" value="XM_014692231.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU76"/>
    <dbReference type="GeneID" id="26240280"/>
    <dbReference type="KEGG" id="mbrn:26240280"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="310"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="750" mass="84904" checksum="CF006AC0709DF66B" modified="2021-02-10" version="1">MGETESPKDTTHHRSACTECQRRKQKVFESPGAHLHFTIPFQPAASTTTPLRASCRFPRPEKMPQSLLSCSCNREWPCNHCQKRKVADKCRFGQSQPSQDKAPRHDFTRKRQLSHEDTESMDSNPWEDADSGFEALGYSASHLFAGLNASSTRKPKHVPKTFRQYYMDPSSCPQLKRALLRLPPRPYTDALVQNFLNHVNFHYYIIYPPSFLEEYKTWWSLRSENRPLSMQWTCLLLMVCACSTQYTDSDLERKLEIDLGQSAQQLTEQYHNAGRELHGAIPVGNNHLLNVQSLLHSCYWYKSEARFVECWHVLSTAIREAQELGIHKETVSGQMSEFDREMRRRIWCILDTWDWQISALLSRPVLIDRTDIDVGLPSLTLEGYTPSPLQHMKLQSELITQLFNRFGLPKDVSQHGDVRAYQVIVDRWMNAFPSTYAFVDPDTSNDASRPWIVLHRHYLHTMAMSMMLDPIRAYLARPMSKQSPPDEVKIRDDGVDYSLRLLDALHGFFGHVYPRDAKFHFVLFCIFDTAAVLCSALMHDQDSSLSKRDDMLVAVDKALSMLKRLNTVTKTARTSYKVLAKIAQNISRPGQEVKSPIMPAKKRPKGKELALTPPCMNQTEVAFASDPGSVDSHASYTTPPSDAHFYGAPASQSTPPGHYFNVDESAGCAPPVPPTSSGAAMSSSNTLHYNGAPLDYSTSYVNMTPPTDEAYHAIDYANFGAITEQDLGELATLWNYESLNLDFINPGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV56</accession>
    <name>A0A7D5UV56_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g052020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539396.1">
        <property type="nucleotide sequence ID" value="XM_014683910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV56"/>
    <dbReference type="GeneID" id="26247796"/>
    <dbReference type="KEGG" id="mbrn:26247796"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="620" mass="69073" checksum="CA09BAD23B468235" modified="2021-02-10" version="1">MSAVTANNEEADRVLRQKRQARGPSACYPCKKRKVRCDGSVPCQTCRKRQHPQICTYHLSMHPQRASVAAPVQDETARSALPVCPGEAGKVSCEPSSLPDEASKNYVYSGDNSFVSILGSRASGANDSVAGELTSVLGLQNTFNIYPFMDSKTPHDRWKLLLAVLPQRAEVLKFFHCYRATAYPFNPIIVDIDQFESELCTYLSTHAAGELHDPGKISDRWATNKSIGYISLLLATLAAGSHYSDVEYPHRQELSIDFANFLFRPSLDTIQALLILGNTLQNMGQSDSAWAMLGTTVRLAQAMGLHAQRNTVRWPECIRTRARALWSTIVWQDSLLSLCYDRPPIVSVTEWPLDDSFFQRQNLSYTEIMHFICRLNLDIMRPETLAVAEVNRAIEGLQQFDGVYQRGQPYLRAWENCTTIQQHLEHLALRMHSSFFISVLCRPAIKTSPAQPPLPHTDILRTRAKASLIDASKAFLDFQALSVIPLRSWSMVHTVLSSTLLLCAWEETRNDPECRGLQQRVIDVFSLSDSTAGDGALLSDNNREWLSARHIRALVKLRNALDQEEGISTTGNENWAGLGANAISPLGTVPDGYLDMLDPAAISPVAYLNSVLNVSLFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV96</accession>
    <name>A0A7D5UV96_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g044640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547797.2">
        <property type="nucleotide sequence ID" value="XM_014692311.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV96"/>
    <dbReference type="GeneID" id="26240360"/>
    <dbReference type="KEGG" id="mbrn:26240360"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="488" mass="54874" checksum="816967C203BE6AF0" modified="2021-02-10" version="1">MHRCLGYDEPFLFVNQALPGTQELRSKKSARQHKDYWNQKLSSFVSVDQDAGTQIAPMVPLVGFKDNIVISHFVSNLRIGFEQNPASTSDAPTMRAAMESFGKRTSAYVSGLSVAETYFSQIHKVAHMQSHGAALYGHALGRLRLDLQYINNDFDRARAFLGLWTAYFLSLYELISSSTSGMWLQHAQGVATLIEMLGPDSFQTASANALLEVKRPFLGISHIVMRKRCFLEAEEWKTGPWAPQPDSKLPGSMLMDVFVTLPGIVEDADKLKADAEKLRSGTLAGAAVMTSRAKLQGRVLSAIHNLSESRWKWEDVYPRVCWKTRINMATTLCLDLEGKPLFETCLNFVGMKRTFEILFYNVSRLLLFRLSDLIGLKEDATANMEHVWQRHGPFLNPLLLPGLGTRESHALEICRIVDYLLNGEQNYHGAYILLFPLRVARTQLESSPKVHDWIGRVLKQFAEEKGLRVGEYLNEVSQTGDGMTPKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVH6</accession>
    <name>A0A7D5UVH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ups1</name>
        <name evidence="2" type="ORF">G6M90_00g042710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547607.1">
        <property type="nucleotide sequence ID" value="XM_014692121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVH6"/>
    <dbReference type="GeneID" id="26240170"/>
    <dbReference type="KEGG" id="mbrn:26240170"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000011">
        <property type="entry name" value="Uroporphyrinogen-III synthase (UroS), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="319" mass="35561" checksum="AC9389E3599B596E" modified="2021-02-10" version="1">MASQSLDIESGDRAASKVPILLLKTRSTPSDAYEEILTTSKPKNESLGRKFDPQFVPVLRHRFDEGGMQRTRSLLLANEIGDRPGCRYGGVIFTSQRAVEAFTKVVNDERGGHGESPFLQNTPIYSVGPATTRALRAIQVEPPLQIFGEHTGNGEALAAYIQHHYGQWYRDREVRPPLLFLVGEQRRDVIPRVLMDPSLLQGERIIVDEEVIYGTGVMKSFSEEFESILNDTRHEPERWVVVFSPTGCDTMLRGLGLLDESSGKVNLEHRDGRTFIATIGPTTRAHLVNRFGFEPDVCAESPSPDGILHGITKFTTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVJ2</accession>
    <name>A0A7D5UVJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g043850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986253.1">
        <property type="nucleotide sequence ID" value="XM_066130336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVJ2"/>
    <dbReference type="GeneID" id="90967682"/>
    <dbReference type="KEGG" id="mbrn:90967682"/>
    <dbReference type="OrthoDB" id="10301591at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="120" mass="12357" checksum="B5AE2E68834AE070" modified="2021-02-10" version="1">MDSSSTQAVHGSASSADAQSGPVTYHHTHSQYGSKEGVLRWVNDPNRPVTVTIAQLSVPSPRQQPATGTGVQGLASQTHSSNITYSTGSAHNSSSGNSSSDINFACMGAQFPVSPFAHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVS0</accession>
    <name>A0A7D5UVS0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial glycine transporter YMC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">YMC1</name>
        <name evidence="12" type="ORF">G6M90_00g043630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986490.1">
        <property type="nucleotide sequence ID" value="XM_066130329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVS0"/>
    <dbReference type="GeneID" id="26240260"/>
    <dbReference type="KEGG" id="mbrn:26240260"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="215"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="304" mass="33057" checksum="8D38AB33D11F0413" modified="2021-02-10" version="1">MAAVEVEEMQGGGLQTAKDLFSGAVGGVAQVLIGQPFDIVKVRLQTTNQYSGAVHAAASIYRNEGALAFYKGTLTPLLGIGACVSIQFGAFHAARRWFEARNAADRGLKANGLSYGQYFAAGAFAGVSNAALSTPIEHIRIRLQSQPHGDARLYAGPWDCVRKLSAHQGLLRGIYRGTAVTVYREAAAYGAWFTAFEYLMNRDAARNGVDRKEIPAWKIALYGGLAGEALWLASYPFDVIKSKMQTDGFGPDQKYPTMRSCFAATWRADGFKGFWRGIWPTLFRAMPVSAGTFAVVEMTMRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVW5</accession>
    <name>A0A7D5UVW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-galactosidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g032700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543201.1">
        <property type="nucleotide sequence ID" value="XM_014687715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVW5"/>
    <dbReference type="GeneID" id="26244002"/>
    <dbReference type="KEGG" id="mbrn:26244002"/>
    <dbReference type="OrthoDB" id="5071209at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="30273" checksum="FAC03904647C89BD" modified="2021-02-10" version="1">MTPTRNSNIQLLATLVDFKDEEEGEYRFLVDGKHAKYVTVDPGVLPRDDRTFAPILLPTLPSFPPGDWNEGHVSKNPLNGELEFSRCTRSDLPGVSNTWHHTRIDHLELNKVSRIRQNIHVVTHPLFDQALLVKFTEFPWQMSFFEAETTAYEWIDGHDIGPKFLGHLTEDGRIIGFVLEYLEDTRSAETDDLAACQAALARLHSLGIKHGDINKYNFLIRQGKAVLVDFEAARKCSQEKELQAEYERLEHSLNDTSRRGATYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ9</accession>
    <name>A0A7D5UVZ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g034380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546836.2">
        <property type="nucleotide sequence ID" value="XM_014691350.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ9"/>
    <dbReference type="GeneID" id="26239399"/>
    <dbReference type="KEGG" id="mbrn:26239399"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="611"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="830" mass="93223" checksum="93D86B5AA6747D96" modified="2021-02-10" version="1">MPNEIKGMVLDLMTAEDVYAFTRTSKDHYRAFRGFIWRRSHPIAGTALSREIRRWAFENKLIREKAATERPHIATAECEINYILRMNRRVLQLGHFWLAVELADCSIISRLAKETNIKEEWEEFRDLDLGDEKRQMFDDLLKLSLKPPTNDLADALLDLLKIDKSCNDDKGAHRLTQALLVACRFGNLELVQKLIALGADPEGVLECEWPLMVACNTGKKELFDLLLKSGASINGSYVKPSQITTLGAAIKGNNAEIVHHLLDNKVFIQEVNNTIFCHADRLFQGGSDSREQLEIRQMLCERLDIKRAWHFPDIPAWLRGAVKANKLDMMELLLEPLLEPLLEQAADEPTSPPKRWKAYDELLGIALDEQSYDVVDILLDAFPQVFRSERLNTLSCKTRAGILDRAMQTGNSALFYPVLSIEDLRKQKENGDTLLHYIREPSAAEKLLLASHISIDALSGSDETPLSKACCQNNMQMVEFLLRRNADMEAKDDRGCKYFQVAVEKADVKLVCLLLEYDADIRSGSANIATKLSMAIHHKRWAGLEALLVKGPPVRLSVFERAVEGEGELVEFATLLIRLNKYTEDVARRLLDIVVQDSQVKLSIVKRLLEGGADPSPSPEDAPEDAPEDAPEDAPEDALEDALEDALEDAPEDAPEDAQGYTDKIHSPISWACFHGRKDIAEILFHHGAIVENDEDGTSPSNAGAWTTLQAAVAGGHIEMVLWLLDGKAGISPSKGDRDSWHSLCIVAVKAEIGMLRFLLGRGKAYLSRDGIEDILKEGVQRNQVQIVQYLIEDFGFTKADFDRMHLLHSARQNRRMMKTLQNYGADINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW60</accession>
    <name>A0A7D5UW60_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g045400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986585.1">
        <property type="nucleotide sequence ID" value="XM_066130376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW60"/>
    <dbReference type="GeneID" id="90967699"/>
    <dbReference type="KEGG" id="mbrn:90967699"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="155" mass="16314" checksum="7BF76FB450079835" modified="2021-02-10" version="1">MCGPEVTNRPRGGALAALSAPKNGHDVPSSCFTQGDLAFHTPGQPGSTEATHARLTPAEACRLADVDKLRVVIHSSGDMTRSAHDCGLFRQFVFPAARLSNNYVEFPLSSPLSLEVGNGGIIGRRVSVSSRSEAGPEVVIAEGIVGFNFLEQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWI8</accession>
    <name>A0A7D5UWI8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g064070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540134.1">
        <property type="nucleotide sequence ID" value="XM_014684648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWI8"/>
    <dbReference type="GeneID" id="26247170"/>
    <dbReference type="KEGG" id="mbrn:26247170"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="536" mass="58299" checksum="282FFAAD1E7DB605" modified="2021-02-10" version="1">MSTEHHDPPGTVLLSSEQSGSIIYQPQPSDDPEDPLNWSALRKCVNLGLVLSYVLLTFVVLDIPPVAYGQLVEDIGITFQLSNVATALNFAGLAIGGVLLIPFTYRYGRRPIYLISIAVQLAATIWAARITSKGEYLASSMLGGLGGAISETIVQITIVDLVFVHQYATMNGVFLVTQGVGAYLGPVAAGYIVQSQGWRWMWWWCVIFIASTLVLVLLFFEETTYVAAIDGVPVAASPKDDTDESVRKDWQEVNTLANTASISTTPPKSASRPFRGRGVMSSKPLRKRLALVTHTEGPIKHHFLAPFTILFQFPAVAYTAVTVGSVMSWMAVIISVAATRMIGPPYNFGPSAIGLINLAPFVGQLISGLLAAPFSDKCIVKMARRNGGLYEPEMRLWLALPGAVLVSAGIFMFGIGIAHNAHWGVLTTGIAIFASGFTLALDIALAYLQDCYPNIIGDALVIVVFARNGIAVIILFYLSPWLDSMGLQNMFIMIGVLSFVILLAPLPLLRWGKQARIMTTKNYQYHSLRQPSRRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX54</accession>
    <name>A0A7D5UX54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">MDM10</name>
        <name evidence="7" type="ORF">G6M90_00g056310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544224.1">
        <property type="nucleotide sequence ID" value="XM_014688738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX54"/>
    <dbReference type="GeneID" id="26242636"/>
    <dbReference type="KEGG" id="mbrn:26242636"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="425" mass="46068" checksum="2FD1E3DEF6249CDE" modified="2021-02-10" version="1">MREFMDYVHSAFYEATGWRRDNSYAALNATSDALLDFQTPRGLRLTLSSLASANFATSYQLGSVGVVDGSISYLFSSVPLRVHMTPRSEDVSLPDLLRSYRPLSPLLPRTPSPPDAATAGPEASLLYGRLYLPQSQLEALAVRRLSPALQLQLSAVSAKHLRDGGTVLGLAQYDVGRYAFEGLASSDGGLLGLRGLYNFGGGDAHPPPAGAEGEKERVYGRFSTGAEVYYGTLNKSGGVSFGTRFATLPAHSGTPLSASLTVNPLMGNVAASYAVVAGRHCSLATRMEFNVFSYESAWAVGMELWRRPLRRVAGGGGRPGGEYKERSFRAKMEWRLDEPELVPPPQPSPPLSEPAEPDRVLAVHRGNGGEEYAGVLKARLDQNWRIGILWEGRVKSLLFSLGSGIDLRKLDKPFRTLGLEIQFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX60</accession>
    <name>A0A7D5UX60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g066060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540166.1">
        <property type="nucleotide sequence ID" value="XM_014684680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX60"/>
    <dbReference type="GeneID" id="26246975"/>
    <dbReference type="KEGG" id="mbrn:26246975"/>
    <dbReference type="OrthoDB" id="4936624at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="758"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="804"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121696" checksum="C3635C4CEE01FEA2" modified="2021-02-10" version="1">MSQSSSDKIKMEKHERGRTHDKSKKASSTKVAKGKKPGNTQRPQHTANEHDNQKEETLSEILSDALQKFPDTCTEACNPVKCERMSCKQRLHDFEVLFKTKLKDMTQRAQEKQDNTLHLLVKDKGWKSEHTTPPKRLFDWMLQQREHDVLLQRRDPRGFTPVHNALYDHVHDFIDVLLKADRLSTISILRQDFAGSNCIHLATQHASPHLSTMIHKCKGDNEIFMDGDKTEKGTPLHIAVQDVFIPVVDEVEEDDSDPEDQGLEDDDQDGLLDCHDNADHDSHHLDEDVDEFALDSDYESSSLSEYETDLELEEVKYRFENKEEREKRLVKILDDLDKEENTRPRPPPRTHDANPDNPQRMGAEDAVDDLAKENNSPSIPKVVMSQGLIDLPPDHSVRLLVEVYPKALIAKNSCKRTPYQEREHVLLSDDVVKRLVQQYAHKKGPRGDTTEIREARAKRTIIVQDPVARYIMSYCIREYKSRELTMQQLYKPGQERHIEFDLEGFPSPSVTHNYFDNLGKHLQFESILRYVALPVLSVEPPPSRNPRIKQVSPTETQYELHRNGRSDLVTVFDWLWSKGVREIVKIRVVDGDLPHADASIVEALYGFNVKMWDWKRVDLCSDVIYESSPVIKEVSVYSSGNNAVLMGWASEDGLGNREKFPCLEKINLFVQDGLEDDKRWQSNNRLCQKKITEHGLKRRDGHGGKEIEFKIIIDNDQGRSTTENIEPAPAWIKSTRQFATFLMNASREQGKDKQVAPVKIAIIDDGIDATLHDLQSKIAGGATFCPYPHSSELVNSYFVPRGKHGTLMAQLICDLCPGTELYIARLEELPLLSGSGRRVTARSAAKAVEWAVNCGVDIISMSWTIQTAAHDSEDMSSLETALNNAKAAKIHMFCSASDQGANTKEEYFPGDWKQCIRIGGATFTGEKLTWVDDKVDFWFPGRNVPFLSRDGKSVVYDSGSSIATAAASGLAGLLIYSARLIYSGTNEARNYPFHTQTAMAAAFRIMAKGMDGKFPRTDEVLNKLFKNKIQQATQKPPKSLDMETLEWSDSSKKALTDLLLHIQVGSPIEEVVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXK1</accession>
    <name>A0A7D5UXK1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase helD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">helD1</name>
        <name evidence="2" type="ORF">G6M90_00g052790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540405.1">
        <property type="nucleotide sequence ID" value="XM_014684919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXK1"/>
    <dbReference type="GeneID" id="26246767"/>
    <dbReference type="KEGG" id="mbrn:26246767"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="490" mass="54336" checksum="0544DC6F6D197CC8" modified="2021-02-10" version="1">MEDFIKQPLRAQTFALSAFDMQGSFSNIPYAFFYGNRGQDGKQKEFMPTTLLKQSLAQTLESFPILLGHIKATARCKLQIDLDPSHINCPDFRETILPNDSNVSFATLEAANFSWKSWPEGVATVKPFAMPHDTTGDIKLLNVHVVRLRDNTGLILFVNCPHYVFDGAGYFAFIKEWASKMRCAASQSLPKPGTEYCHDRTCIQEYLTARKRPLDPVSNAIYATANFLCDAMTWLSPVHLGRLLGKLGSLSPPGQAHLFHITQQALDSLQKSSQEHLPEHVARLSTNDLLVALVGRTYVQSQKQPVPRAGWFSPAPPPETHFSVRIPCDARPRLGMKHNFTGNLLVPVLMRDTMEDYGQKTTAASLARSALQVRRCVGDVDAALVSGYHDVLGEHPTSYMRPLAFAASHTTTSMVATSQVRFGLYDADFGFGKPAFVSLTPLFEGAYTMAAFLPPPPGKDGVYILLTTNKDAMAGVVENDFWRQTCELVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXR3</accession>
    <name>A0A7D5UXR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyribonuclease Tat-D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pi038</name>
        <name evidence="6" type="ORF">G6M90_00g048590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544974.1">
        <property type="nucleotide sequence ID" value="XM_014689488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXR3"/>
    <dbReference type="GeneID" id="26242315"/>
    <dbReference type="KEGG" id="mbrn:26242315"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="43679" checksum="C1C22B29741DAFFA" modified="2021-02-10" version="1">MASQAGETPNGTYKPRYVDIGINLSDPIFRGRYHGHQKHPDDLTGVIDRARQVGCTKLIVTGSDIKSSQDSLNLAEEYPGTCYATVGIHPCSSAIFGAADLKKKQSEHTTPCEGDPYAPMSEEHHPDAARSAHAISLLTTVVAQARSSSQPHMVAMGEFGLDYDRLNYCNRVIQKHSFEAQLRVAASLQPQLPLFLHSRAAHGDFVAILKGVFGERLENLDKGGVVHSFTGTMEEMEELMDLGLYIGINGCSFKTEENCRVVKAVRLDRLMMETDGPWCEVRPSHEGYKYLIERKAAQAPVENGTAAPQAAAPEPQAKQPKKQKNQKKQPEVPDRFKIVKKEKWEEGAMIKGRNEPCTIERVAQIIAAIKDVSVEEVCEAAWKNTVHVFRLGETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXT0</accession>
    <name>A0A7D5UXT0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TRYP_7</name>
        <name evidence="5" type="ORF">G6M90_00g055810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544174.1">
        <property type="nucleotide sequence ID" value="XM_014688688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXT0"/>
    <dbReference type="GeneID" id="26242586"/>
    <dbReference type="KEGG" id="mbrn:26242586"/>
    <dbReference type="OrthoDB" id="4915747at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028937957" evidence="3">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="26"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="337" mass="35532" checksum="B4FADBBD5424C778" modified="2021-02-10" version="1">MVPNIAIALAAFSVVSSAATTIDRRVIGGEDAKDGEFPFIVSLSGRGGQCSGSLLDSTTVLTAAHCLEGRFTSNRRMGGVIADIASAKEHPSYIKGHGVHDIAILKLSTPIERNDTIGIGYAVLPENGSDPAPNSMAITAGWGVQGNGNPGYNHVVNKLAKVVIPVREREKCRLQFNPPEAHPDTICAGVNGKDACHGDSGGPLIDQETGQLIGLVSRGQCTNPPTVYTRVGSYIPWIEDHLGGVGSGPIPISTTSSVLPKGTPTAGQKRPWIELVNYGIVASCGFTENREEECGTEIYCGLFDWSPSHDGAFKNSKECLDAHVPKPKAARASIPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY11</accession>
    <name>A0A7D5UY11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EGD2</name>
        <name evidence="9" type="ORF">G6M90_00g060420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544612.1">
        <property type="nucleotide sequence ID" value="XM_014689126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY11"/>
    <dbReference type="GeneID" id="26243024"/>
    <dbReference type="KEGG" id="mbrn:26243024"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="203" mass="22165" checksum="B41D19053559A166" modified="2021-02-10" version="1">MANPRIEELPDEETQRPTVEEQEDSSDDSDAEDGEANLPAGSTAVIHNRNEKKARKAIEKLHLTRVPGITRVTLRRPKNILFVINNPEVYKSPNSNTYIVFGEAKIEDVNATAQQAAAAQMAAANAEAEHAGHNHGEPSKAVESGEAKKDEDEDDGEEVDAEGLEDKDIELVMTQANVSRKKAIKALKENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYM5</accession>
    <name>A0A7D5UYM5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spo12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g062810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542601.1">
        <property type="nucleotide sequence ID" value="XM_014687115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYM5"/>
    <dbReference type="GeneID" id="26244550"/>
    <dbReference type="KEGG" id="mbrn:26244550"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10712" checksum="8C5E2B27DE138405" modified="2021-02-10" version="1">MSAVLGDKDVNAVMDQQNAAKDVKSMEYHRQVFQSKMAAETTKQYVSPSDNIMSPCTAKINALRNKHASKAKPKSLFAQASVKKLNGENSLGARSIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ32</accession>
    <name>A0A7D5UZ32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cat-1</name>
        <name evidence="16" type="ORF">G6M90_00g078510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986998.1">
        <property type="nucleotide sequence ID" value="XM_066131090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ32"/>
    <dbReference type="GeneID" id="26241290"/>
    <dbReference type="KEGG" id="mbrn:26241290"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="25"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI70395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="713" mass="79663" checksum="210B3DE9E2C20CF1" modified="2021-02-10" version="1">MTTKTAKADQLEASMVEPTPKDRITADFGTKQSNTDDWLRVRSDKTTGPTLLEDAFAREKIHRFDHERIPERVVHARGAGAFGTFRLLESAEDVTHAGVLTDTSRETPVFVRFSTVLGSRGSADTVRDVRGFAVKMYTQEGNWDIVGNNMPVFFIQDAIKFPDLIHAAKPEPHREIPQAQSAHNNFWDFMYMHPEATHMYMWTMSDRAIPRSFRMMQGFGVNTFTLQNARGERHLVKFHWTPELGVHSLVWDEALKIAGQDPDFHRRDLADAIDAGVYPRWKFGIQVVPDAKADDFDFDVLDATKVWPQELVPVRYIGELELNRNVDEFFTETEQAAFCTSHVVPGVGFSDDPLLQGRNFSYFDTQVSRLGVNWEELPVNRPVCPVMNFNRDGAMRHTIARGKVNYWPNRFEAQPPASREEGGYVDHPQEVRGVKMRAKSDKFKDHVSQAQLFYNSMSDIEKRHIAAALSFELDHCEEPIVYERLTQRLADIDMGLARAVAAMVGGPSPAPSPGQNHGKTAAGLSQLEYVPERVTIASRKVAVLVADGYDAISYGAVVTALKAARAIPVVLGPRRSPVFAAGEDSQSARGLVPDHHFEGQRSTLFDAVFIPGGGITHYVREAFGHLKTVAATGEAVDLVRKAVQLDGVRFSGDGDAVLSYGVVTLRDPKPESLKEVVQATKGAKHFLDQLFWSMSQHRCWDRELDGLAAQVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZM3</accession>
    <name>A0A7D5UZM3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vma-6</name>
        <name evidence="8" type="ORF">G6M90_00g071780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987114.1">
        <property type="nucleotide sequence ID" value="XM_066130958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZM3"/>
    <dbReference type="GeneID" id="26241914"/>
    <dbReference type="KEGG" id="mbrn:26241914"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="363" mass="40757" checksum="F25683B8D8F101BF" modified="2021-02-10" version="1">MEGLFFNVNNGYVEGIVRGYRNGLLTGTAYNNLTQCETIDDLKLQLGPAYGDFLASLPPNPSTSSLAAKTTDKLVSEFRYVRANAVGSLAKFMDYLTYGYMIDNVALLITGTLHERDTRELLDRCHPLGWFETMPVLCVATNIEELYNSVLIETPLAAYFKGSLSHQDLDELNIEIVRNTLYKNYLEDFYHFVNSHPDMAGTPTAEVMSEILEFEADRRAINITLNSFGTELSKADRKKLYPNFGKLYPEGTLMLSRADDPEGVRLSVDGVHDYKTFLEAASLGGSSGPGNMGGGSADGKTLEDMFYQKEMEISKSAFTRQFTYAIVYAWVRLREQEIRNITWIAECIAQNQKDRIGNFISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZS5</accession>
    <name>A0A7D5UZS5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987028.1">
        <property type="nucleotide sequence ID" value="XM_066130897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZS5"/>
    <dbReference type="GeneID" id="90967907"/>
    <dbReference type="KEGG" id="mbrn:90967907"/>
    <dbReference type="OrthoDB" id="4942411at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="122" mass="13424" checksum="D8142AEF046BD753" modified="2021-02-10" version="1">MEGLHWQMCFVVQPFFHDTCFPEIWNTVWVPKNTDSHTVVTVDKDMYAVFKDDASSAALEGGTLPSHTVAVHPSHGPKVIHNTADSDDVEIRVVTPLPYDRISGFNEPVCGHSTSTATEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V096</accession>
    <name>A0A7D5V096_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyketide synthase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Pks2_2</name>
        <name evidence="13" type="ORF">G6M90_00g079000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Polyketide synthase; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987015.1">
        <property type="nucleotide sequence ID" value="XM_066131099.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26241244"/>
    <dbReference type="KEGG" id="mbrn:26241244"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF45">
        <property type="entry name" value="CONIDIAL PIGMENT POLYKETIDE SYNTHASE ALB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="366"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1286"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1641"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1757"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1286"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1447"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1614"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1726"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1635"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1727"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2149" mass="233447" checksum="272D6AFFF3EE2ECB" modified="2021-02-10" version="1">MQPHRVFLFGDQTGGFATGLQQLLLDKTNPSLVYFVDHANLALRQELSRLPSTDRETLPLIGSVQDILTLHKKGERNVVIDSILSTVKYGNAGCAYPNGQNIHVTGMCVGSLAAAAVSCSRSIGDVIVAGIVAIRAALRVGLRAHQAALLTSNRAAPHTHWSYAVSTESLRLDLIKDALEKFAQDMDTSPLSHPYISAIGLDSVTVSGPPSQLHQFWRENTTFHKPIPIPIWAPYHGPHIFGDIDVETIIESLHPIPKLSQQAPIISSGSGVMASQTLADLIRAALRDILLHRLDLPALVGHIKDIFRSSPNQDFSMTPIATNAATGLVAATAKAAGNTGSVDNEIMDAAALAGSASRATSAKTHDSKIAIIGMSGRFPEAADLDSFWSLLEQGVDAYRPVPPDRFDAHAHHDETGRRKNTSKVLGGCWINQPGLFDAKFFSISPKEAEQSDPAQRLALQTAYEALEMAGVVPDRTQSTQRDRVGVFYGMVSDDWREINSGQNIDTYFIPGGIRAFTPGRINYHFKFSGPSITVDTACSSSLAAIHVACNSLWRGDCDTAVAGGVNVLTNPDIFAGLDRGHFLSTTGNCKTFDDDADGYCRADGVGTVVLKRLEDAVMDKDPILAVLNSAYTNHSAEAVSITRPHAGAQERIFSKLLRETGINPHDVSYIEMHGTGTQAGDATEMSSVLRTFAPDSGRLSNQTLHLGSAKSNVGHGESASGVTSLIKVLLMMKHNMIPPHCGIKGRINHRFPTDLRERNVFIASQPVAWNRPHAGSGKRRVFINNFSAAGGNSALLLEDAPAGEHPETKDPRSTHVVAVSAKSATSLANNLKRLRDFVQDNIHDLDSLSKLSYTTTARRIHYPFRAAMTASSGDQLLQGIESVLLRDEMPKPRKSQKNIGFVFSGQGAQYAGMGRHLFQNNHTFRTQILACNQICLSQGFPSILEIFKQDVDMNSLEPLVVQLATTCLQMSLVSFWKSLGVTPDFCIGHSLGEYAALQAAGVLSVSDTIYLTGIRARMLQEKCSAGSHAMLAVRAPLARVNALLDPAIHEVTCLNGPQDVVIGGRVADVEELERELAKQDIKAVKVSVPFAFHSTQVEPILGEFCDAARGVPFQTQTIPVISTLLGEVVHPETTGVFGPGYLKRHCREPVNFAAAVQAARDANLIHAGTVFVEIGPHPVCSALLKSNMGPDAVTLASLHRKDDGWKVLADTLAALYQAGLKINWDELHRDFASCQEVLPLPSYSWDNKNYWIQYVHNWTLTKGDEPAAMAEATALQAPDGLTSSVQKIIRQTDGPGSLVTIVVQSDFGSARLADVAQGHKVNGEMLCTSSLYAEIGMTLGRQLLEKYRPDLQGYSTEIQDMSVDKPLILKDENKQTLFRAEVVHDKSTHTASMSIYSVDSAGNKTVDHARCLLRFADPNSWLEEWERTYYLIDRSVHWLEERAEQGTDSLLSRGIVYKLFSSLVDYSPSFKGLQEVILNSGDREAAAKVRLQAEKGDFDCNPMWIDSFGQLTGFLMNGHDFTGKDEVFINHGWRSMRCAKPFRKDAVYRTYIRMQHVEKTKYRGDLYIIEDGVIIAVFGGMTFLGMSRSLLNKVLPPRRGAEAINTPHPVAAAPQGMAASAKDTERRPLDIPTRAQRQPSSPQTGTMGRILAILSEEVGLSMEILTDDLVFADYGVDSLLSLTITGRIREELGLDMDSSIFTHYSTLGELKAFLGADQLPDDAVACESSNGQHTPQTSDKGSGTLAAQKPDDDIGPDTTLNRVCAIIAEEVGISVQELSSSQDFQELGIDSLSSLTILSRVREELQLDLESDFFDTHPSFYSLQKALCGTGAASNGATEANETTPSSHRLESDLRSITWQSGQNIVASPPHATSILVSGSPSTARMILVLFPDGSGSAASYGALAPKIRRDIAVYALNCPWRTNGEEILRLGVTLDTMVAKHLVEVGRILDSHRHGRPGSGNSSVGLALGGWSAGGILALEAVRQLGEAGVAVQKMVLLDAPNPIGLQNPPPRMFHFLDELGILGAGKGKAPAWVLRHFDAMVNLLKSYRPRRLEAEDAPKCLIVYARDGICKDPDGPRMDTKPDDAREMLWLLYNRVDFSAEGWKTLVGQQNLAVGVVEDVNHFSMMNPGPKMVEMGNLIGEFLLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0D2</accession>
    <name>A0A7D5V0D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g078810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545228.1">
        <property type="nucleotide sequence ID" value="XM_014689742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0D2"/>
    <dbReference type="GeneID" id="26241261"/>
    <dbReference type="KEGG" id="mbrn:26241261"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="57"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="275" mass="30526" checksum="C094C7C73F45DAB1" modified="2021-02-10" version="1">MGYASEEEIKAGEPRFVKYNYNDVAIPEDFLAGPPPEPVKMGHVDFASSSIPEYEGKIAVVLDNVLSEPECQQFMELAKEAVPDWSPALINVGGGLESHIPKYRSGSRKVWDHQGMVDSIFNRCLEAPGVKEVLARPPKLDETSDQAAVNPEHWELVGLNNRLRILRYTQGEYFKAHDDGSYSPPSENGTRYASFYSIHVYLNSSTMQSPPPEGGCVGGATSFYSEDETRSFDIQAMTGRTLIFQQSGLRHSGADVTEGVKYSVRTDVMYRYIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0I5</accession>
    <name>A0A7D5V0I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">G6M90_00g088740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542241.1">
        <property type="nucleotide sequence ID" value="XM_014686755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0I5"/>
    <dbReference type="GeneID" id="26244755"/>
    <dbReference type="KEGG" id="mbrn:26244755"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI71558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="548" mass="62704" checksum="2E85E4F53EB9AB6F" modified="2021-02-10" version="1">MDDEPIAAQSSSNDTHNDAIPPLSSSPPDTIILESPSLDATTPISPRLSRNPSFSGSSSHHDDWDPLPPLDRLTVLDLLDNLALPQQLEKLQKGISAQTDKVRRSKDAFKSRTQLARHRMVEEWRRRVPSADEQFDRYRKRMRQRVEKLGRQWNDTKAITLREKISFICGVMNIFISGYLIGGYPQYFHLWYTAQLVYFMPIRFFTYHRRGYHYFLADLCYFVNMLLFLSIWIFPNSKRLLTATYCLAFGNNAVAIIMWRNSLVFHSFDKVTSLFIHIMPCATLHCLVHLHSPEDQKSRFPAIWAIKNSAPGSSTAYANVISMLAWSTIPYAFWQLSYYFFITVRRRDKIAAGRPTSFTWLRRSYSKTWIGKVVLSLPQPLQEPAFMMIQYSYAVLTMLPCPLWFNSRFASSAFLLVVFAWSIYNGSTYYIDVFGKRFQKELEAMKAEVLKWQNTPDLMLQSPLLTPHPDIVSASAAGQQLQSLDPEPGTVMSNFHGGRSPNGMSRPGTDMGRTTSLDKIPLLDENIDATSTSVDGGARDIARERKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0M4</accession>
    <name>A0A7D5V0M4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g073390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545726.1">
        <property type="nucleotide sequence ID" value="XM_014690240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0M4"/>
    <dbReference type="GeneID" id="26241759"/>
    <dbReference type="KEGG" id="mbrn:26241759"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23600" checksum="712EAFDFC76144F1" modified="2021-02-10" version="1">MPADFEKQSYWHDRFASETSFEWLISSSEFVFIIEPFLEALDPSSAHILNLGSGTSDLQNHLRSRGFHKVCNLDYEPLAVERGRQLEEKAFGNVVTHYTVADTTQLAYAGPEIGRRADGKFDLVIDKSTVDAVCCGGQAALLRMAQGVRSRLADDALWISLSFSASRFDNHQLPFHVETIAKIPAPKIKTTDPDIYHWCYLLRPIRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0S6</accession>
    <name>A0A7D5V0S6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kduD_1</name>
        <name evidence="6" type="ORF">G6M90_00g083520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543572.1">
        <property type="nucleotide sequence ID" value="XM_014688086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0S6"/>
    <dbReference type="GeneID" id="26243749"/>
    <dbReference type="KEGG" id="mbrn:26243749"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="27657" checksum="AEDA77200C47F11A" modified="2021-02-10" version="1">MSAPIFSLQGQTAVVTGCTRGIGQAVAIGLAEAGADVILVQRDTSVTSTKEAIEKLGRKAWIYTADMADQQSVKALTPKILADGHELRILVTCAGIQRRHPCEEFPDSDFNEVMQVNLNAVFTLCRDVGAHMLHLEPSPTTGRRGSIINFASLLTFQGGFTVPAYAASKGAVGQVTKSFANEWTSKGITVNAIAPGYIETDMNTALLNNPERLASISARIPAGRWGSPDDFKGTTVYLASRASGYVSGHTLVVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0U0</accession>
    <name>A0A7D5V0U0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987343.1">
        <property type="nucleotide sequence ID" value="XM_066131179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0U0"/>
    <dbReference type="GeneID" id="90968049"/>
    <dbReference type="KEGG" id="mbrn:90968049"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20529" checksum="53327BCB8C915B9F" modified="2021-02-10" version="1">MAKVAVSLVGDSPWALEQPRLDIGKSKADFVQKFKDRFVDCRTQFISQQISGVSGYENSNGEIKEQSYEGNEEKSSSIACRIYNAKGDGPVDLDASCEDQEGGCEFCVNKGKSKTPCGEVENWTCQAQKPRMGTEAPGEDEGTPLEWDAQGNLVDPTGRIIHPAQEADKVPKKADEFIGPYFTTGKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1F7</accession>
    <name>A0A7D5V1F7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g086240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541182.1">
        <property type="nucleotide sequence ID" value="XM_014685696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1F7"/>
    <dbReference type="GeneID" id="26246171"/>
    <dbReference type="KEGG" id="mbrn:26246171"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="208"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="619" mass="69204" checksum="56F9E37F2E62F30B" modified="2021-02-10" version="1">MVRPLPRDEFPRQPSFQPCFPPTTRHASFSQERYVADAVQRPDSFLQDRYGVDPGDSRYQEPYDLHRRQPPMAIPEALRSLCGIAGKQYFVAVMSEDGEPITYLSPPQKLDAITIGQFFDKSKFQQVMARVNSGADPILDNGLQLEDASFSRSGSFGRMRPSDRRRSSIFDDLEGPTRSGRKRPRPRHPINEDDDVPMTVSSRKGIKVGDGDAVWNFYEQRFKNCQQTACKLIAKAWVKAVEPKKQSTHPYTGSDEKAPDWWPKPWGPTKDDKVRHKEPDHLYKRERVHLLAHILRLVIEPNGRQHNDIQKLGLNVKKLEETTAEALSSFFMDNDTNAKKKPYLTEIFKMARQEERFKNGEIDGSTEVYVMAEDKLPENYASENEDGNFLKDEEDHELQRPKANTQHHCAVQTPTTGPGSAQTLHGGHGPFTGELPVRGHSFNPSMLPADIPSQPHTFMDSNGITVTDQTSVTAPSGPLALDMVTSPHDTSRRPSVFSEYASPGGSSMYAQQWQQPQPGSTGPGQGSMYAYTPTQGNPQQPPYIGQGVPMNPNTPFIGGSFEGSPRPDYEANGPPIFRTGDMPHAPVNQSQGYYVPNDGRSGLRVITQVVDGVSRNQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1H6</accession>
    <name>A0A7D5V1H6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">G6M90_00g074180</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987084.1">
        <property type="nucleotide sequence ID" value="XM_066130995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1H6"/>
    <dbReference type="GeneID" id="26241681"/>
    <dbReference type="KEGG" id="mbrn:26241681"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI70752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="458" mass="51801" checksum="7F5AEEDC5792B849" modified="2021-02-10" version="1">MGRSKRGVRFPHSNGQANGSEGRRSSFSDASEDGSGSPTRTRKVQAMQLPPVEEKPPTPEEEYQKKKANFITRTFWTLCMLGAFFTALFMGHIYIIIIVTMVQIVSFKEVIAIANVPSRARSLRSTKSLNWYWLATTMYFLYGESVIYYFKHIVLVDKVLLPLATHHRFISFILYVFGFVFFVASLQAGHYKFQFTNFAWTHMALYLIVVQAHFVMNNVFEGMIWFFLPAALVITNDIFAYICGIAFGRTQLIKLSPKKTVEGFVGAWIATVLFGMVLVNLMVRSKYFICPVNDLGATIFTGLQCDPNPVFIPRTYHMPQLFFLPPSFTNISFTFAPMQLHALVLASFASLIAPFGGFFASGLKRSFKIKDFGDSIPGHGGMTDRMDCQFIMGFFAYMYYHTFISLHKVNVGTVLETAITSLSPEEQIDLVKSMSRYLGNQGVVSEKFLECVERTISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1L8</accession>
    <name>A0A7D5V1L8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPI10</name>
        <name evidence="13" type="ORF">G6M90_00g087060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542412.1">
        <property type="nucleotide sequence ID" value="XM_014686926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1L8"/>
    <dbReference type="GeneID" id="26244926"/>
    <dbReference type="KEGG" id="mbrn:26244926"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="602" mass="68143" checksum="181BFBFC0C11CFC9" modified="2021-02-10" version="1">MAISPAHIRRNERNRPNFLRDIIIIRLINAWWIATFFQPDEYFQSLEPAWRLAFGPNSGAWLTWEWQHQLRSSLHPAIFSGGYLVADGISKLIPAGNMLRSAIVVGSPKVLQAMIASLGDWYTWQLAVNIFGPDSNASFFALFLQLFSAWQWYCSTRTFSNSLETTLTVMALYYWPWRIFSAAVSTKENPKPANILGNIWGLRLSLCLAAFAVVLRPTNLLIWATISGMALTRASLKGSSPLTWSMILLLAREAFLCGSLILGTSVASDYFYFGFWTFPPYNWLNFNISKSLAVFYGRNPWHYYLSQGAPLLCTTSLPFALWGLYKPGSSSTNERNILRVLSSAVFTTVVALSLISHKEVRFIYPLLPILNIVAAPWAASFFTSPPSSKAATSRPRLRNKPYLIAALGVNLILAGYLSFLHQPAPLNVLSYLRKEYERVHPTSVRLAHEAHQPPTPRDELFALFLMPCHSTPWRSHLYYPGLDAYALTCEPPLDTQPNTPARDNYRDEADRFYDDPIGFLTNELFGPQPKIGIPRYIVGFEGIEPWLLTFLDTPAGKALGIKPRRVWGGFNGFFNEDWRRSGRMLVWDTGVYLDAPHDKHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1N9</accession>
    <name>A0A7D5V1N9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSM10</name>
        <name evidence="8" type="ORF">G6M90_00g088530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542261.1">
        <property type="nucleotide sequence ID" value="XM_014686775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1N9"/>
    <dbReference type="GeneID" id="26244775"/>
    <dbReference type="KEGG" id="mbrn:26244775"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="7">
        <location>
            <begin position="88"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="250" mass="28389" checksum="43AB8F5D3FC1690C" modified="2021-02-10" version="1">MPGSFSRSKASAIPASLPLTLARTSRRTFASITLDHDLKYNSQSRSSTSTSSLAKPIQIDQVRQPRSLQALHLKPLKREAEFGIPSCDLQLRSFSVQPLEFFSDFALRAAYYLGLPAYGPIPLPRITERWTVPKSHFIFKKAQENFERVTLRRMIQIRDGNPETVQLWLAYLRRHQFYGVGMKANAWEFSQPGLDPSQNMRDEQLDQLGDVWSQLGQIGDLGSPEKVEDLLNSRRFKDAAGLRQPLATNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V200</accession>
    <name>A0A7D5V200_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g102260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546120.2">
        <property type="nucleotide sequence ID" value="XM_014690634.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V200"/>
    <dbReference type="GeneID" id="26240543"/>
    <dbReference type="KEGG" id="mbrn:26240543"/>
    <dbReference type="OrthoDB" id="5415512at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="995" mass="110661" checksum="7B47C356B21C30EC" modified="2021-02-10" version="1">MGQRWKRWYSSTSAEPEIDLLSTAFGIPSRRDLERASETVRPKPSSRYDSDSDATGDNAQVEFGSYDSSDQSSIHGITIKSRNKGLNHLVSPIPKSASRKRQHTQSRSSSLKSQRSTLSKKIRGSRKLKITTRDYKQPSPTLTPKDEEPSSTSTSPSTYLSTANGLPGSQKSSSSPSWINSNAQRAAPNKASQPPLLYSQQQLPTFLPHYVPPYLFHQQKDLLATPTPKRNQDASSYSLGSNFQELQELQELQLKLDRLRRELLKEPTDSHLHRDHQNTQSQLNNLLDSVVAHKTKGVQQSSLNTTEIPADAMKSTEPIVDKENVAPAPVNDEVAIEAQFPSVPQGGRDRTLSIAHLREKSPSCTIRHHLCSDCGSVRSRKFHEKHPIDIWPKPVLNFCSSCREITLQKGQMDKHHFCFGCGKVRSKAFQKKHKPKPGLPLLPNYCGKCTAEVRVNEGLDEISVLELTAQSIRPPEHDGSVADTASSTVADLFRHGSPHCNSDLPSEELGVKTSKSRNPAKLRLGHASIAKSSSAPVSPAESSPFYPGRRSGSAQRRAQREPAPHINGEHRRKTHHLVVQGEYHAPYVEEADSASENRMSLRNHSRVESLGDEAFSKQYRERSGRKSRKERIGTEGQKLAPMQIPGVIYERTAALQSSNSSGEGTIQCDLRIDSSGQHPKLKMTRESPQYNPQDLPHQGSFHEPSRFSKGVFGKSNKDSGCGSGQAIRQKSPLADIECSHYTTTFSNREDDKSETRTAAAEKPEPARFRSSRGAFGPDYSPKQSHFSMFQFGRTGSNQSGTRSPDATENNRSAPRAEWEENNSQIGTGEYSQPGHRNSTAPSFSSGSNASKPTNKFKPHIPNETAYARSVFTDYSRSTDNPYYKPRSRPIHNATNSEFCSTWDWKSNRGASTQNPRPYDWHFHDGVPEPIIEEPASPPSSPVQPTKLLEFHIPRDDSSLWKPETEEDNNCLAERIDLDPTVSFSEVTEPMSAITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2M0</accession>
    <name>A0A7D5V2M0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unsaturated rhamnogalacturonyl hydrolase YteR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yteR_0</name>
        <name evidence="2" type="ORF">G6M90_00g093660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540735.1">
        <property type="nucleotide sequence ID" value="XM_014685249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2M0"/>
    <dbReference type="GeneID" id="26246348"/>
    <dbReference type="KEGG" id="mbrn:26246348"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="378" mass="41405" checksum="A77C4E64BE29870C" modified="2021-02-10" version="1">MTAAACTSQRMSTHMLDSIVARKQGVVDSGAASSTLESGILAQAIEDIIALYPKTKCQYNRYLSSVLDIASAPLTNATIAATKPLDRFSLATAIHTALTSKVAPVTAQSQNAYQAINASLALQTRNAAGGLWYYVYPEWSYLDGMFSLLPFMSTYAPAHTNLTDMVLQVSLLRDHCTQKNTSLLFHGYDYSRRAIWADPRTGASPYVWGRSLGWFLASLVQTWDKLSCQGVQRGELLTLCNLTKDIAVQLSRSLVQYADPETGAWWQIVTLPGERGNYLESSSTALFTFSLLKALRIGLLSGHQTDYKSAALKAYEYTLREFITDTGNGTIGFNQTVSVCSLNSTASFEYYTTRPIVPNSLLGQSAFILAALEVERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Z9</accession>
    <name>A0A7D5V2Z9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NPC2</name>
        <name evidence="9" type="ORF">G6M90_00g085360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541093.1">
        <property type="nucleotide sequence ID" value="XM_014685607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Z9"/>
    <dbReference type="GeneID" id="26246082"/>
    <dbReference type="KEGG" id="mbrn:26246082"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="8">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17047" checksum="712F884049168680" modified="2021-02-10" version="1">MAWLATCLTVVAADSLKVPGESPLEFCNSNRDHDAVQIDKVDISPNPPKPGKPLIVTFEGVVKKNIADGAYAKVVVKYGLIQLLSTTVDFCEQTQNVDLNCPLEPGKMVITKSIDMPSVIPPGTYNVLADAYTDDDENISCLKATVNFPRPGLLGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Z3</accession>
    <name>A0A7D5V3Z3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Splicing factor 3A subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SF3A2</name>
        <name evidence="12" type="ORF">G6M90_00g098810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546466.1">
        <property type="nucleotide sequence ID" value="XM_014690980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Z3"/>
    <dbReference type="GeneID" id="26240889"/>
    <dbReference type="KEGG" id="mbrn:26240889"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="241" mass="27240" checksum="618D6E1ABB1069AB" modified="2021-02-10" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALETIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGKKHQTNLARRAAREQREGKANIDPATGLPSSVAASFAGGGARRNAVKIGRPGYKITKIRDPVTRQQGLLFQLQYPEAAPDMSPKWQVMNAFTQRVEEPDKNFQYLLVAAEPYETVGFKIPARELDKREGRGFCFWDPDAKEFWIQIMFMTEREERFNAAPGLAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Z5</accession>
    <name>A0A7D5V3Z5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DOPA 4,5-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DODA</name>
        <name evidence="1" type="ORF">G6M90_00g107680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544075.1">
        <property type="nucleotide sequence ID" value="XM_014688589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Z5"/>
    <dbReference type="GeneID" id="26243462"/>
    <dbReference type="KEGG" id="mbrn:26243462"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="191" mass="21679" checksum="342A5646FF87C223" modified="2021-02-10" version="1">MTRISVPGAPRPQDDLKTVVETRTREWHFHIYFLLQSPTETAAALALRDAVLRLRRDGAFVAVPLHRVNKYPIGPHPAGSYEIWVPDSSFSEVFFYLASNRGNLSILIHPLTSEQRRDHETRNGWMGTPWPIYLDSLPTESDEVPLQYSELRLGWSAAPEEEISLDERRRRGAEVEALLARDPEAAPAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V480</accession>
    <name>A0A7D5V480_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Abasic site processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HMCES</name>
        <name evidence="9" type="ORF">G6M90_00g110840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543776.2">
        <property type="nucleotide sequence ID" value="XM_014688290.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V480"/>
    <dbReference type="GeneID" id="26243163"/>
    <dbReference type="KEGG" id="mbrn:26243163"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="373" mass="42026" checksum="1DF5D0881EBAB60F" modified="2021-02-10" version="1">MCGRYALALRASQIRQMLQDDDMPVDYSVDDEDGPGAPRQSYNFAPGYHGVVYRADTPDWGAGPRSRSHQAKGTDGDEAAPTEEDAATAGQVKYKLQSMKWGLVPFWTKRNPDYQTLMRTINCREDSLSTPGGMWASMKNKKRCIVIAQGFFEWLKAGPRDKLPHFVRRKDGRLMCFAGLWDCVRYEGSDEKLYTYTIITTDSNKQLKFLHDRMPVIFDPGSDHITQWLDPARHEWSRELQSLLKPFAGELDVYPVTKDVGKVGNNSPSFIVPLNSKQNKSNIANFFSSAQKKGPKDAESAAVKTEDSSVERKPVEEDEREKRKEPPTSPDRPVKKTASEKAKISSTKNEHKSPRKVKGPGSQKITRFFGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4L5</accession>
    <name>A0A7D5V4L5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g109060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065988003.1">
        <property type="nucleotide sequence ID" value="XM_066131770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4L5"/>
    <dbReference type="GeneID" id="90968244"/>
    <dbReference type="KEGG" id="mbrn:90968244"/>
    <dbReference type="OrthoDB" id="4956309at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="74" mass="7848" checksum="35A4AD09D9359BB0" modified="2021-02-10" version="1">MPSAGAVYNGSAPPKPDHAYTNHGIASGEQNLGNDRLTLFFERDPYSNSSGPASREARVAAQLKAVSEAFQPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6V1</accession>
    <name>A0A7D5V6V1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enniatin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ESYN1</name>
        <name evidence="9" type="ORF">G6M90_00g106200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539610.2">
        <property type="nucleotide sequence ID" value="XM_014684124.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6V1"/>
    <dbReference type="GeneID" id="26247607"/>
    <dbReference type="KEGG" id="mbrn:26247607"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="839"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="910"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="947" mass="103858" checksum="E2CFEFCD3AC9C6A6" modified="2021-02-10" version="1">MISQGNAAPTRSDPATTVVSMPSHGDADNHTTLEMPTKPTLKGVDSEASVRFWQQHFDGLDASAFPTVTSSTRVLRQDGLLEHKIAYMTSPTQQKWSNVAICRAALAVLLARYTHAPEALFGIVVTHLDPDSKNQTAKPAQAVVPTRVLCAPHQSCSCLLQHVTAHDATVSQLDRAGLDDIRKAGEYASAACGFQTVLEVVTKASSNELHGQEIATSDAFHLCTDRALFLECQMADDSAFIRARYDQSLIDARQMTRFLGQLGCLIKTFLGSVADMPLGQLQPLTQEDQTEINDWNSAELESSDVCIHDVIAERSASRPGSTAVFAWDGEWTYEELDSLSSRLAAYIQSLGLDHEQAIPVCFEKSKWVVVGILAVLKAGLAFTLIEPSHPPARIAQICQQTSATIALVSRMQYNTLRNLVSQCIIVDDEFSQSLLAYQDGFISVAKPQNLAYIIFTSGSTGEPKGCMIEHRGFASCALKYAPELHISRKSRSLQFASYAFGACIIEIVATLMQGGCVCIPSEQDRMNNIADFINNAGVTWALLTPSFIGAIRPESIPRLQTLVLGGEALSAEIRDTWASQVQLLCGYGQSETSSICSVARIDPGMADPSNIGRATGARLWITDPDNPHQLAPIGCIGELVVESPGVARGYIVPPPQTKSPFIAGTPSWHPTSRYLDRFSFYRTGDLVRYKSDGTIVYLGRRDLQVKIRGQRVDIGDVETHLRQQLPSDVVAVAEAVQRPSTSHNTILVAFLVGLKQNGQDNTISATRASILEPSVARDITAKLQQLIPQYGIPSYYILLERLPTTATGKTDRRKLRSIGAELLDEMTQNMTSKEETPTDSPISREETLRQLWFRNLNIDPKSHIQAANFFDLGGDSIAAIKMANMARSAGIELSVADIIRYPDLSNLVNKVTHDKEKPPPPKHEPRRKFYKRLWGRRSKGTPNQSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM29</accession>
    <name>A0A7D5YM29_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MAP1</name>
        <name evidence="12" type="ORF">G6M90_00g005510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542197.2">
        <property type="nucleotide sequence ID" value="XM_014686711.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM29"/>
    <dbReference type="GeneID" id="26245228"/>
    <dbReference type="KEGG" id="mbrn:26245228"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF1">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="154"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50932" checksum="5CEA0389933D23F7" modified="2021-02-10" version="1">MGSKTLENEERREHEVPSSSGSRSAGGEPRGSHLSRDGDGCMGSQGADEGDDDDDDDLDESHAAAAVSLTCPTSGEASNETKKKKKKRKRSKKRKAQTALKQSSPPRIPLHRLFSSGEYRPGELCDYQTTSAVKAPELRHHGQRALEDPTFLNNYRKAAEVQRQTRKWVQESVKPGQTLTEIAVGIEDSVRALLDNAGLEPGQGLQSGLGFPTGLSLNHCVAHYTPNPGQKDVVLQHQDVIKVDFGVHVNGWIVDSAFTMSFDPTYDDLLAAVKDATNTGIKNAGIDVRISDVGAAMQEAMESYEVDIRGKTYPVKPGRNLCGHDIKHYRIHGDKTIPFVKNSNQTKMEEGDIFAVETFGSTGRGFIRDGAGIYGYGLSHSPRERVSLPRSSANTLYKTIKENFGTLVFCRRYLNHINYLVSNGILDDYAPLMDVPGSYSAQFEHTILLRESTKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN75</accession>
    <name>A0A7D5YN75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g023510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548204.1">
        <property type="nucleotide sequence ID" value="XM_014692718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN75"/>
    <dbReference type="GeneID" id="26237648"/>
    <dbReference type="KEGG" id="mbrn:26237648"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71153" checksum="A153A0D7B05AF03B" modified="2021-02-10" version="1">MPGYHVPISGPMMQNPYHNLGHLGTYPDQSHLHASKTGKGCKKGNRDCVYPDPPASKSSKSKDNNASQKTSPKSSNEGDDADMDRVTNSLQTILDEDEPEELSSEERSDSQLSGSKATGSSNRNVTTRQSTESLSPDGIKDSSPSVSTGGSSVTVAPSIDLNIPTDGRADWSHLPLDYQHYLNYFVENITSFHYSIMHDADDFFGTILPSLAVQHEPLLNAVVGFATYHATLQNPAGKLQDFLKYYNKSVTLLLESINRKEMNNILNLITILQLLTIEEYFGDWINLMGHQKAAFQVVRKIFTPDTVMHTPVGRACIDWYTRYDCYVAIMGGFPTDLPREWFNRMNEYNESQLGASPDEFRWKISSRSTQLRSISYDMSMLYARGSRGQIGPEDFTKEHKRITNELLEWKSTWDAALSVPEYLVTDFSYQRDVVPGDIVNPYMLGLLYEQPLFTNTLITTEWTSIMIMHLSQSSDIPAEQVFIEMAKHAYTICQYFETVEFWPLKPKGALIPLQPCISIAALFLPRDSRHQMWVRRKFALLDTMGFIHPTTRRIKMAHLFRDPSCAHWWLPNDEGLTPILQAIRTFADERNTAAVNAQQENIREVRHLFAKMEAAELALTTGNDVTGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPC8</accession>
    <name>A0A7D5YPC8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trichothecene biosynthesis protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRI14_1</name>
        <name evidence="2" type="ORF">G6M90_00g029410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541229.1">
        <property type="nucleotide sequence ID" value="XM_014685743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPC8"/>
    <dbReference type="GeneID" id="26245864"/>
    <dbReference type="KEGG" id="mbrn:26245864"/>
    <dbReference type="OrthoDB" id="4434395at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12811">
        <property type="entry name" value="MALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054550">
        <property type="entry name" value="Mala_s_1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22701">
        <property type="entry name" value="Mala_s_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028862395" evidence="1">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="359" mass="37809" checksum="20C3A621BB00E6E6" modified="2021-02-10" version="1">MRAGVLPSLTALGAVASALPATDGANGANGNTAAGTDVIINVPQLYPESADFNKKNGLTYFSKLYNAAVAVVDVSKDSVVDTITFDRTDVAEFHASGVEIDQKTNQLSVTINAGIAFDTAGANVSGDNFLYKVDLNGDKPKELWHANLTAVTNGAYGGCQDMVHDTCGNTFVVCTYPGAIIKVNADGTKAIPWYLSNYTKPGTSPILPGLTGIVASGDLLIANDAQAKQLVSFNKRDSLGKRVVIPVTGLTGESGDDGVYLPEKYGGKVLLTQLSTEGTNVFVSKDGWKSAEFVTKIASAYTPQDKGGFAVATVQIQDKIYGVIEYFLDDKNGGLAGNRTKFELEDLTTKIDQAVQGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQC1</accession>
    <name>A0A7D5YQC1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aphA_0</name>
        <name evidence="9" type="ORF">G6M90_00g006400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549867.1">
        <property type="nucleotide sequence ID" value="XM_014694381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQC1"/>
    <dbReference type="GeneID" id="26239311"/>
    <dbReference type="KEGG" id="mbrn:26239311"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029033243" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="172"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="422"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="537" mass="57898" checksum="16E24807DD88892F" modified="2021-02-10" version="1">MKSGFVLAASLRGAIALLSPRGPDAAGQIRLAYHGADGMTVSWNTFEHVKAPSVKWGLSKGKLEHTASSNVSLTYPTSTTYNNHVVISGLKPDTTYYYLPSPLPQGNHLEPYTFRTARAAGDSDAFAVAVVVDLGTMGRLGLTTSAGSSVSQNNILKPGEKNTIDSLASTKSSYDFIWHPGDIAYADYWLKLEIQGVLPNTTIPDGHTVYEAILNDLYDEMAAVTETKPYMVGPGNHEANCDNGGTTDKAKNITYDFGICSPGQTNFTGFKNHFRMPSDVSGGTGNFWYSWDNGMVHFIQLDTETDLGHGFTGPDEIGGTEKEGASPVNATMNAQATWLEADLASVDRKKTPWVVVAGHRPWYLSKKNVTGTICWPCKDVFEPLFIQYNVDLVLTGHAHVYERLAPLANGAIDPNELNNPKAPWYITNGAGGHYDGLDSFDEPRQKYSRFGLDTANATYGWSRLTFHNCSHLTHEFIASNNNSALDTATLFKDRSCGSCHGNGNGNGNGDGGAHHSGAAGSATREPTRPTKVANGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQS8</accession>
    <name>A0A7D5YQS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein prenyltransferase alpha subunit repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g008860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549625.1">
        <property type="nucleotide sequence ID" value="XM_014694139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQS8"/>
    <dbReference type="GeneID" id="26239069"/>
    <dbReference type="KEGG" id="mbrn:26239069"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="38951" checksum="B534162FB9B6B515" modified="2021-02-10" version="1">MSSAIDGSLRRGSQNEDPKEIYDAISHELSQIYHPYIDIELLPKGFETELKNTYFVKEEHCLAIPKLRLVQAFTAARQILISHLNKPGSISTDDVRKATSVMLLMDSEHLTAANTRKRLLLRQTLAACERKAELGREMYFVNSLLSSHLHRHTKSPVLWSHKHWLLRQYLEAKVPIDLMHDLESVVFVAAERHPKNYYAWTYARDLFVSRAKVKPGWDAEQDEELMRMTAKWCRLHHDDISGWSFLLHLALGSPQHAQEIFRQTARLVQTYTWRGESVWNFLRTLVLVPAMRDSSEVRQSFVDLWHHVRQDIRDAQSLDAKVLDRAAAWAEIPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQX9</accession>
    <name>A0A7D5YQX9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA exonuclease 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rex3_0</name>
        <name evidence="8" type="ORF">G6M90_00g042910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547625.2">
        <property type="nucleotide sequence ID" value="XM_014692139.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQX9"/>
    <dbReference type="GeneID" id="26240188"/>
    <dbReference type="KEGG" id="mbrn:26240188"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="193"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="407" mass="45610" checksum="3F37AB96BB4105D2" modified="2021-02-10" version="1">MATERSYGPVQPTPDYLQLLHHYVQPHGQLKKAGYIFSRLSSTDLQRKERCEKCCKVLKNRRQRNQPAEPKLPSASDAAVSRPNHLELHSSNRASGAVVTESQINPHTKQALDKAAKGTERTQDGSSGNTSFICSYHPGHVANRKWTCCNGPLFSKPCAGQHEHSPRHYNVGELEKNWQFYETKTAPLPTHVAAVVLDCEMGTASSGESELIRLSVVDFFTGAVLIDSLVYPSVKMAHYNTRFSGVTRHTMDDSRRRRKCILGRDSARQALYKFVGPDTVVIGHAGHQDLTSLRWIHHRIVDTLILETGKRRLEEDLSRRREWEESENTEMGESANPSSAVEDKDNTAATNLQEGGLSLKALTLKRLNRTIQVKGRGHDSLEDALATRDLLHWHIDAILRSDTEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR07</accession>
    <name>A0A7D5YR07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconolactonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gnl_1</name>
        <name evidence="2" type="ORF">G6M90_00g050880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545188.2">
        <property type="nucleotide sequence ID" value="XM_014689702.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR07"/>
    <dbReference type="GeneID" id="26242529"/>
    <dbReference type="KEGG" id="mbrn:26242529"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="392" mass="43898" checksum="A94E90330D6C14D2" modified="2021-02-10" version="1">MPVFADYEAVALIPFSFGFISQVLLGSYNMSISNISLLAAATDAGYFASLLPANSSTPAISLRAYHDDFYNLIGHEARARKVWDLPWEAFHEAGVYNRRDNSLYIASNYQSLEDNINITVVSLDSDDYPFYSTQFPNLAMANGGTTYYPPGSRHDETTTPPMHVYCDEGDFEHDSKLVAVDPNTNRSKPLLTSFLGRGFSSLNDVRQHPQTGDLWFTDADYGYFQHFRPEPSQPKQVYRFEPDTGIVQVVADGFVQPNGLEFSPDLRTLYISDTGSQQFGREPTQPSTIYAYDVVDKRRLANRRTFAWADTGFPDGVHCDTRGNVWAACGDGLHIWNPRGVLLGKIHVGEMSNNFAFAPGKVFVFSNSRLWVVENIRAQGREVCRDFGVGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRB0</accession>
    <name>A0A7D5YRB0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g036240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986202.1">
        <property type="nucleotide sequence ID" value="XM_066130179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRB0"/>
    <dbReference type="GeneID" id="90967617"/>
    <dbReference type="KEGG" id="mbrn:90967617"/>
    <dbReference type="OrthoDB" id="4958063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6413" checksum="B022D2D69025B0CD" modified="2021-02-10" version="1">MTPGSSLALLILGIMSLVGLVFWFFKSQINKYVSALLAYKRRLTDTEQAAEDSTAATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTN2</accession>
    <name>A0A7D5YTN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Laccase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Conidial pigment biosynthesis oxidase Mlac1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ASO</name>
        <name evidence="16" type="ORF">G6M90_00g024850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Laccase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress. The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA. The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pigment biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548096.1">
        <property type="nucleotide sequence ID" value="XM_014692610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTN2"/>
    <dbReference type="GeneID" id="26237540"/>
    <dbReference type="KEGG" id="mbrn:26237540"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04206">
        <property type="entry name" value="CuRO_1_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="92"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="229"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="482"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="627" mass="69957" checksum="7714CA4171A7E07A" modified="2021-02-10" version="1">MVNIAPRSPWRVLTGVSLTVFTFTGLTLFFVIVLKHLDVGFLTNSRQLAATSHGTDGNLSHYGELEDDSFALHPEQHVFRAPHTIRLGWNITREARRPDGVLKDVYLINGQFPGPTIEARSGDTIEVTVANGIAHDTHDGIAVHWHGLLMKGFNDMDGVVGVTQCSISPGQSYTYKFEIHKEQHGTFWYHAHSAVKRADGLYGGLVVHKPADSRAVQSDASLYGYESEKMLLIGDWYHLPADRVLAEYKDFRNFAYEPVPDSLLINGAGSYNCSNARPGKPVDCVETDAPEVKVPGNKAVRLRIVNTGASAGYSLQLEGASFQLITVDGGTAVSRSTPQSSTLGVLYPGERMDVLLLSDEASPNRNKPHNSTMKIILDLELMQLMNPALTRMQSFSLSWIPSAKTEHQRQGNPPKVDIYNIQNAEGLLIPEDAPLRKNPVEVALLYTSLSINSFKNDEPWGELNHTSWTWKDPQARPLLAIDRTEWENGTEQANPLRTFRVPRYEAGEDRWFDLVVNNVDDKGHPFHLHGYEYYVLSSRQGELGRPYNPFEGDHSAHRVNTNTALKKDTVYIKPRGYVILRFPLDNSGLWLIHCHVLWHQAVGMGVVLQVGNISQTSAHKAEKSCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTT5</accession>
    <name>A0A7D5YTT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g061400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986778.1">
        <property type="nucleotide sequence ID" value="XM_066130718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTT5"/>
    <dbReference type="GeneID" id="90967837"/>
    <dbReference type="KEGG" id="mbrn:90967837"/>
    <dbReference type="OrthoDB" id="4950153at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="36358" checksum="3752C8653D4B6C92" modified="2021-02-10" version="1">MSWNKSITLYFLELLLKARRNNPLLSVKKTAFRELCKSLVKDMEVKFPDENWTVKKLENKHNYLRCFWRAFRDAAERPGTTYNPETKTLRMSDQNIHLIRSKYPRNGKAVTSQPLLTNDAIDYNEWLEIFSLEAPAGQDLTKADTIKVGDANVVESSRHSCVTDWLKRCAHSMDNASSPLTSVEDGDHSGDIVVQQPRKRRRTLRATSQSSTPSPTLPATLLDGLQKGEPQQLAAFIALSKVIDGIARQGGKHNIIIQPVGAEDLEKACIDAQRLREEHGVTLVLRVLSWLLKDPRNAIIWNALVSNELKMAWIASDFGQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTX3</accession>
    <name>A0A7D5YTX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g064150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540127.1">
        <property type="nucleotide sequence ID" value="XM_014684641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTX3"/>
    <dbReference type="GeneID" id="26247163"/>
    <dbReference type="KEGG" id="mbrn:26247163"/>
    <dbReference type="OrthoDB" id="3545073at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="804" mass="86374" checksum="04DB57C73A35775A" modified="2021-02-10" version="1">MDLPLGPVDDEKADPTWDADGSHWSTSSDDEEESVTAIDDLPRVSGTGSLATATHVRVELSNRPHLALFNKAAGAPKMEARGNIKHEPLEPARAQSSDSDDSSLASIPAIARLKETPVPLPPTVAAAGQLPASVSSQPRLAGVPSTTPRAPPAPRASGPASTPTPVPLPPTVMQNASAPQVSGQTPSSSAPATSLPDSRKPAATSSTPSSGLGGSLHLPFTNEKIEPTLPHGAHSTATPRKRYPVPMEIAADGRPYTVYVQPNGKSVPTKGVLIPAGYELHSDPQLPFSCPVRGCQRRFKNLAALSGHFGSSHSNMTFNDNGDGSISKFGNYRNPSGRSPGIVVAQVPFPRATHPALKRGLGEDGAGPSKRQLEESDAGQDRKRRAMSEDREHNQTTQFETDVSKYMATVHSGFRTANRRDISRMLALPRKRDLPEEFLDKHTYTDLAAQTYACAVAYVVGDEVSGRSACHAATGPLACLSKQCIVLPKSIQLDPKIVRIFTPHHRCVGCAYLALMTSAPDRCELRTEPSNAGSGDKVVPTSSGRPLPDVPTLRSSQPAPQQEQQSSPMPSGQGTEQTPSRRPVRQSVLNRLQMDKDQAARPKSKSPTEQPSTQVNRPQTDRDQTARSQSKSPTEQPGTQLNHTDKDQVARPQSKSPTEQHSSTRLERGTLPIKHHGQFGTPEYEMEDWEIAPGRVTNEDASRNIAYSGAFLTSSTPITISHDIDFNILTIRPGQIFNVPVQKGKIQVFSVASGKLKVTTGGKVVQLGPNGVFPVRPGEKCVIENRIYFEAVVHCTTVKDYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU39</accession>
    <name>A0A7D5YU39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g084590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543675.1">
        <property type="nucleotide sequence ID" value="XM_014688189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU39"/>
    <dbReference type="GeneID" id="26243852"/>
    <dbReference type="KEGG" id="mbrn:26243852"/>
    <dbReference type="OrthoDB" id="5421689at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="365" mass="40265" checksum="712D870DC04723F6" modified="2021-02-10" version="1">MASLVPNVWAAIVIPVPASVLAVILRLKARRMTRMGMGRDDCFAVAALIFALGYTADLIVWATCFKLGQPIGSYSQDLIDYYTEKSTLILWTSEFLYSWAIFCAKIAVLCFFLRVFRFASIRIPIMILITLCSIWITIRTFFTLLRCRPIQAFWVQDIPDATCFTNVRAYYLATDVTHSSMDFIILALPIYEVSRMRLPFGQKIAVVGLFATGSLVGIASIFQIVESQNYDPHELPYDLALCMVWGGVELHLAVFVGSLILLRPIFIKFVPGLASLSASKAASRPTRSSNAFQPGESSRRPSSLPDDAELGMEAVDATMTIGRGSSLALKEHTSSLTPICIHHEECDAETLPGQDDSGHSQSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUF2</accession>
    <name>A0A7D5YUF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ari1</name>
        <name evidence="5" type="ORF">G6M90_00g017350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548795.1">
        <property type="nucleotide sequence ID" value="XM_014693309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUF2"/>
    <dbReference type="GeneID" id="26238239"/>
    <dbReference type="KEGG" id="mbrn:26238239"/>
    <dbReference type="OrthoDB" id="3004402at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="326" mass="37275" checksum="86E3048EF5A913B2" modified="2021-02-10" version="1">MFGPLSHQPEPKLFEKRTDGNDFQCPPSILSTACHSLVEEMTERVNDFFLTNWPFPDEARRRAFVAGQYARVACLAFPMANNDRIYLICVLLTIQFLIDDAFGDLSFSQGRALAEHIAHLCRGQRLPNRAVPMEWISYNLFRDMRELDAERASHVADAVEKSMMVQTSTRRGKDMGFSQFVEYRSVDVGTLILFALVPFSMGLEPKLGEREEVRDVNANFARHFLGMNDLVGYEREVMESKAGHEEGGTLINSVSVLAAELCLSPEATKRLLWQMCREWERRHRELARDVLRGGDSPDLETYVKCLEYMMTAGEVWRLATARYQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUS9</accession>
    <name>A0A7D5YUS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase helD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">helD2</name>
        <name evidence="3" type="ORF">G6M90_00g052770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540403.1">
        <property type="nucleotide sequence ID" value="XM_014684917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUS9"/>
    <dbReference type="GeneID" id="26246765"/>
    <dbReference type="KEGG" id="mbrn:26246765"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="486" mass="53977" checksum="D65560AD6F2F430F" modified="2021-02-10" version="1">MEQAWSNIESAHFDLSPLDIISSHLYISNVFFFENTQSARDWLPEELLKQSLYDALRGFPMLLGRLQRGWGNTMKVVVDKDALNPPSWEVSETAALSFRTLKAEGFHRRLWPKGIRIAEPQIARTAGDASKLVRVHVARLADNSGVAIVLRIAHAVVDAKGAVAFMRHWADCFRRRNNVVVSATASPSPPPQTSAALVCRRSVMYEKLSQDARPRPLPWYMWPLSMLLVAVVSLLGLILKRNLTAGRTRSHLFRVRRDKLDAVKSLATTGAKPSNGISYNDVLVAIFTIAYAQCTMQEKSASSPSSRGGIFRRKPPQARAIVPCDFRHRLGVPEGYTGNCAVGLFVTAPSETLLRPMTETSVMEVARFSRSTTSAADGATIEKLIQRAMRSIQLLGDKVRILYSLMICQAFSNQSRLPFYEVDFGVGRPVFVSPMAYPRTVAVIVPPPPSLAMGHDVFFVYLTLEECQMSRVLGNGGFQSFAEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXB1</accession>
    <name>A0A7D5YXB1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cdc17</name>
        <name evidence="16" type="ORF">G6M90_00g087710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987514.1">
        <property type="nucleotide sequence ID" value="XM_066131315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXB1"/>
    <dbReference type="GeneID" id="26244858"/>
    <dbReference type="KEGG" id="mbrn:26244858"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="15">
        <location>
            <begin position="590"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="829"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI72622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="865" mass="95901" checksum="970DF6070834BFCF" modified="2021-02-10" version="1">MAPPKQATLGKFFGVKNPAPQQQTKLTFATKARAVEGGDEDASAKENTDPDNDSKKRARVPSQNSTVKPEDDEDDGPVVKRVRRSRVKVEEDEDDEPAQSVPKKEDNVKDVTIKQSVEEVPKMEGDAKDVKIKKKSQSPDPDRKPLKTADDGFKEEAASESGSEAEEDADVDEKPEVAAKAREKVQTQLQSKTAQHPYPDWQPGSPVPYAALCQTFSLIEMTTKRLIIMGHCSLFLRQVMRLTPDDLLPTVLLMINKLAPDYAGIELGIGESLIMKAIGETTGRSLQIIKADQKEIGDLGLVAVKSRSTQPTMFKPKPLTVRGVHQGLMNIATVTGNGAQGRKVDGIKKLLSAADAYSTAKADITKDKGGPSEAKFIIRFLEGKLRLGLAERTVLVSLAQAIVCHEAGQKGKVPSTTDMENGESILKTVYSELPSYDAIIPAVLSHGIMNLRECCKLRPGVPLKPMLAKPTKAITEVLDRFEGQKFTCEYKYDGERAQIHYVARDSDQELSQETSGAAKQAADGVASIFSRNSEDLSKKYPDILAKLHTWVKNDTKSFVLDCETVAWDVSEKKVLPFQQLMTRKKKDVKLEDVKVKVCVFAFDLLYLNGLPVVEKSLRERRELLQQSFAPVEGEFAFATYMDGQELDEIQLFLDESVKASCEGLMVKMLDGTESGYEPSKRSRNWLKVKKDYLAGVGDSLDLVVLGAYYGRGKRTSVYGAFLLACYDPANDTYETVCNIGTGFSEQVLEELHAQLSEIVIDRPKPFYSHSAGGQHQPDVWFEPRYVWEVKTADLTLSPRYKAGCKEGVDPAGDKGISLRFPRFIKIRDDKKPDEATSSRQIAEMYRKQESVTKNKGPSVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYD0</accession>
    <name>A0A7D5YYD0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caffeine resistance protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">caf5</name>
        <name evidence="7" type="ORF">G6M90_00g094100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987566.1">
        <property type="nucleotide sequence ID" value="XM_066131471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYD0"/>
    <dbReference type="GeneID" id="26246388"/>
    <dbReference type="KEGG" id="mbrn:26246388"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="130"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="566" mass="62680" checksum="67D0983A34F80D10" modified="2021-02-10" version="1">MADLIRDAPIGQIIRWITNNRRLQYPEEKPGFKLPTKWTHNPFNDLDSGLCSPTTIRSGPSSPRQPGFDGDGDYELETITFDRKKSIGSPRASEFNNELKDDSNLHVVDWYGSNDSDNPYNWSNGKRFLITLIICLYTFVVYMSSAIYTSSTEGVMKEFKVTIVEATLGLSLYVLGYGIGPLIFSPLSEIPSIGRNPVYIITMTLFVIISVPTAFASDFHTLVALRFFQGFFGSPCLASGGASVGDIYSMEALPYAMLAWVSASYCGPALGPLLSGFSVPAMHWRWSLFETIWASIPVLVLMFLFLPETSSEGILFQRAQRLSKLTGKRFVIRSHMDKTHGSRTSALVGALIKPIEISFKDPAVLFVQIYTSIIYGIYYSFFEVFPLVYPVYYGMNLGQMGLVFLCVLIACILGVIAYSVCLYFLGRSGFATQERRLLPALGFCFGPTIGLFMFAWTARPSIHWIAPTIGITIYGASVFVVFQCLFIYIPLSYPNYAASLFAANDFFRSAMACASVSFAHPLFTNLGVARGVSVLGGLSLIGIAGIWLLYWFGGRLRAMSKFAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYD3</accession>
    <name>A0A7D5YYD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NMRAL1_0</name>
        <name evidence="5" type="ORF">G6M90_00g005820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549922.1">
        <property type="nucleotide sequence ID" value="XM_014694436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYD3"/>
    <dbReference type="GeneID" id="26239366"/>
    <dbReference type="KEGG" id="mbrn:26239366"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="38331" checksum="D4824314F5015901" modified="2021-02-10" version="1">MKTALVIGGTGAQGVPVVKALASDSKYAVRVITRNASSKDAIELATIPGVTILEGNTYHEPTLREALKDVDYVFANTNGFAIGEMAEIYWGIRIYELCRESRVKHFIYASLEYASKLGNFDPKYRCGHVDGKGKVADYISAQPITPMAWTVVTSCMYMEGLSEFLQPFPDREDPSTLVFAAPLGDGKCPLIYLEDYGHYVRWVFDTPSRSSGMQLHVATEDIAWKDLAAAFTKVTGRKAVYKDLTLDEYFKLPIFPNPEMTVGHSTSGENPTLFTFRENFSGFWNMWKDNLTKRDYELLDEILPSRVKSVQEWMEKSGYTGEPSPVLKDYRDGVGSRNAPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYH0</accession>
    <name>A0A7D5YYH0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g100810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546268.1">
        <property type="nucleotide sequence ID" value="XM_014690782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYH0"/>
    <dbReference type="GeneID" id="26240691"/>
    <dbReference type="KEGG" id="mbrn:26240691"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="49"/>
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    </feature>
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        <location>
            <begin position="583"/>
            <end position="592"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="592" mass="63156" checksum="2E47D28EEB98E2B9" modified="2021-02-10" version="1">MGSEPLTAERDTTSRSQQGRADSDGNHNTRTVSVHTNHDDSDASLERNEPGSQDENGDLPMSKARCIALVATVTGAAFLNVLNIQSVVIILPTIGRRLDIPESRQQWIVSSYSLAFGCFLLLWGRIADIYGKRLIFILGSLWVTCVTAANPFMPNETAFNLFRGLQGLGAAATVPTAIGILGVTFPPGKAKNYAFSTYGAGAPLGSVCGNLLSGLIAEYANWRWVFGALAILSAIITVAGILLIPPRPPPPPPSDTKPDGSVSESQPPAVDWLGAALITTALLALNLSLTEGNVVGWATPWVPVILVMSILLIALFALWQICLERRHARGVSRAPLIKTSVFRNRRFTAAMVIMGLFFAAFNNYLIFTTYFFQDFQGLSPLNTMLRYIPTGVTGVLVALIVAQLLSRIPTLFILVCGTLATSVACLLYAVPIPPTTTYWAYGFPAMVLAVVGADTTWPCLTLFTSQALPREDQAIGGALINAVGQFGRSIGLAVGTAIQTAAMAKARGVVVKEAGPIRQWDADSLTGLRAASWVNFAFGTASLLVVVTAFRSMDIIGKSRPAATLVRDESGGGIVSTENNSNDLERTVAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYW8</accession>
    <name>A0A7D5YYW8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g023360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692733.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26237663"/>
    <dbReference type="KEGG" id="mbrn:26237663"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39195" checksum="75634DB2B639FA68" modified="2021-02-10" version="1">MQFHVKRTLEGGHDIRGYELPSWALLVFLVDILALIPVFLLFQYTFKLVYPVFAMVEDENPPAYEPVPLDQSVSGGEEGVARNSFKPTNGRPRTVTSSFRAINRLLMANGGVAANFRGFFCYLAQVLLTTLLMGIFTGTFGGYLFPVATLLASLALVQYSTAWVHIVISEPSPLPFWSRLPPFRRTFEATWQAVTIFWFASEVTRFVPVIMALVLGITMPQGGFNEPLDMDALGPGFFAKSLVVSVVTVAASVFVIIPAYVVLVRVQASLLPVEQSTIIPFDRSFEGKVEPEVVGGKGYATVSDAWTTFSKTSWRRLLILYVKMFCLSLAAMALFVAVLVPQTIFIAKHSKEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ90</accession>
    <name>A0A7D5YZ90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PRPS2</name>
        <name evidence="13" type="ORF">G6M90_00g036970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986173.1">
        <property type="nucleotide sequence ID" value="XM_066130200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ90"/>
    <dbReference type="GeneID" id="90967633"/>
    <dbReference type="KEGG" id="mbrn:90967633"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="323" mass="34793" checksum="ECFAEC57385F2EC3" modified="2021-02-10" version="1">MLDQMANEIKLISGSSHPNLSAKVASRLGINVANTMSLNYSNQETSVSIGESVRDEDVFILQSTAPGDVNDGLMELLIMIHACRTASARRITAVIPNFPYARQDKKDKSRAPISAKLIANMLQVSGCNHVITMDLHASQIQGFFNVPVDNLYAEPSVLRWIRENLESENCVIVSPDAGGAKRATAIADRLNVGFALIHKERPRPNVVGRMVLVGDVQDKVAILVDDMADTCGTLVKAAETVNQHGAKEVYAIVTHGILSGKAIENINASCLAGLVVTNTVPLGDKTERCPKLKVIDVSATLAEAIRRTHNGESVSYLFTNAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZL0</accession>
    <name>A0A7D5YZL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g028580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541307.1">
        <property type="nucleotide sequence ID" value="XM_014685821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZL0"/>
    <dbReference type="GeneID" id="26245942"/>
    <dbReference type="KEGG" id="mbrn:26245942"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24555" checksum="67F0E204F3C71AFD" modified="2021-02-10" version="1">MLSFLRRGDVERTNSADNNPVMYEGGASSVLFHPPNSKSAMTHTIPPTSAENGTSIVQPPFHYHVYQAETFRVQSGIGHFFRGIDAGVWKVLSAEPGVESTATVGPCTYHRFENASKTEDLVVDIQLDPENYEGEQRFFRNFFGYLNDCKRANKTPSFFQLMVILHSADTPLALPLPSHRLGVLVSRLFLIIVAFWGRWIMGYKSTYPEYYQPRKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0L8</accession>
    <name>A0A7D5Z0L8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fahA</name>
        <name evidence="16" type="ORF">G6M90_00g010300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549488.1">
        <property type="nucleotide sequence ID" value="XM_014694002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0L8"/>
    <dbReference type="GeneID" id="26238932"/>
    <dbReference type="KEGG" id="mbrn:26238932"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="131"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI65967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="428" mass="46774" checksum="692E1AF3B279D0CD" modified="2021-02-10" version="1">MSWLTISPESHFSIANIPFGIISTSSDATKRPAVAIGDYALDLKAFASGGGFSASSEIQKHQDVFAAESLNNFAALGRSFHRSAREYLQSIFSADTKHPQILKDNEQLKKTALLKRADVQNHLPLNIGDYTDFYAGKNHAYNVGVLFRGPDNALQPNYTHLPVAYHGRASSVVVSGTPLHRPWGQILKDPKAEPKIPTLSPCQRLDLELEMGMFICRENKLGSPIPIDEAENYIFGYVLMNDWSARDIQAWEYIPLGPFTAKNMGTAISAWVVLADALNNSRTAGIPNDKTLLPYLQEKKKDNCLNIHLEVDLTTAKGNKTTISRSNSKNLLWSWPQMIAHHTITGCNLRPGDLLGSGTITGDKPGSEGSILEQTQGGKVAVKLQGGEERKFFEDGDTVTIRGWAGEQGALIGFGEVSGTILPAQPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1I5</accession>
    <name>A0A7D5Z1I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GPCPD1-like C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g009290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985782.1">
        <property type="nucleotide sequence ID" value="XM_066129666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1I5"/>
    <dbReference type="GeneID" id="90967440"/>
    <dbReference type="KEGG" id="mbrn:90967440"/>
    <dbReference type="OrthoDB" id="4956549at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPCPD1-like C2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="121" mass="13697" checksum="A08C1C034B52D574" modified="2021-02-10" version="1">MPLQIMLKLYRCESINSKVVVSSGTSSLDEESLLGEKYESLIRERTVYLMDKETSAPAGTVLLSYVVAKPFPGLQKPSTSNQTDLKTLSFNLLGIEDADRMYQVGHFSDLEKIRSRYVELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z288</accession>
    <name>A0A7D5Z288_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARD_1</name>
        <name evidence="6" type="ORF">G6M90_00g057870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544367.1">
        <property type="nucleotide sequence ID" value="XM_014688881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z288"/>
    <dbReference type="GeneID" id="26242779"/>
    <dbReference type="KEGG" id="mbrn:26242779"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="316" mass="33774" checksum="9F9C7E9940373B47" modified="2021-02-10" version="1">MSGSAPAFRQLVNASRSTVSAVVPGPLHSIQRGASHSSARSRNIVSSTKSRLLPEFSLKNKVVVVSGGARGLGLVQAEALLEAGATVHAIDRLPSPANDLSSPFSEVSQRAKDELGTALTYHQADVRDVALLNKIMENIANQSNRLDGLIAAAGINHETQALEHSADVANRIMSINVTGVFMTAQAAARQMVRLKQPGSICLIASMSGTIANKGMYAPAYNASKAAVIQLCRSLAAEWGQHGIRVNSLSPGYIMTQMLQNLFDDFPERKVLWPTENMLNRLSMPHEFRGAAVFLLSDASSFMTGSDLRIDGGHAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2K8</accession>
    <name>A0A7D5Z2K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g018180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548718.1">
        <property type="nucleotide sequence ID" value="XM_014693232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2K8"/>
    <dbReference type="GeneID" id="26238162"/>
    <dbReference type="KEGG" id="mbrn:26238162"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="517" mass="55191" checksum="ED7D52D8F3D9A079" modified="2021-02-10" version="1">MQRQDEALSVPTPPEFLPANSSLVDNLPLTLPNTLSVSKVKGITVIVTLAGISFLNTMGSGILIAALPRIASDVELSDALILWPAAVYALAAGCLLLIFGAAADAIGAKIVWITGSYLFVVFTVALGLANTGLQVILFRTFLGVAISMCLPTAVSLITNTFPKGTWRNVAFAMNGMGQPLGYALGLVLGGIFTDSIGWRWAYYMMAIINFVLSTASIWSLPDVEPGGEKRWTKRLAEDIDWAGAAIMSVALGLLLYALATITTSYASIKGPGTIACLVVSVILLVMFPMWMNYQTNRGRPALIPNSLWKNAPFTTICLSVFFCWAALNGIEYFTTLYFQQVEGLPALQSSLRFLPHVIMGICVNAATAYLISRVQVQTLAVVSALITVVAPALMATIKVGENYWYAPFWALFLSPVNPDVLFTVSNLIISDAFPVDTQSLAGGVFSEVSQFGNSVGLAVTAAIAASVTEHSGSKDTRIALMDGFRAAFWTIFVGAAGVAVICFFGLRRGGFIGKKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2S6</accession>
    <name>A0A7D5Z2S6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter prlL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prlL_5</name>
        <name evidence="9" type="ORF">G6M90_00g077110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545390.1">
        <property type="nucleotide sequence ID" value="XM_014689904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2S6"/>
    <dbReference type="GeneID" id="26241423"/>
    <dbReference type="KEGG" id="mbrn:26241423"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
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                <person name="Kouvelis V.N."/>
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            </authorList>
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        </source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <strain evidence="5 6">4556</strain>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="122"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="428"/>
        </location>
    </feature>
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        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
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            <end position="361"/>
        </location>
    </feature>
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        <location>
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            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="76263" checksum="43B306A7C5C5CD5F" modified="2021-02-10" version="1">MENVQFVQFDDNASPRSSPRPKPRPIPTPSEAIRLPGYGLPLNYLPPRKERFPVLMGDRNKDWKATTLLIREVCMLKFMEDITNKPEWWRKVCDPNIAARWKQEVLSLNWAEYRKHGDFTKNMAEMCIQELRKKAALYEETSLIPVMDHSTCVIKSDKLVSEDLTERLKTAVKSLEHVADSDKDWHPGSDGKVLDLVHPSLFPLLYGRSRIMRHQRIGLDECLNFCGRGFLLEKPGDDSESQLEATIDWRRAPIEVVSPRFQWLPCDVAIDEDGRATIESYINNLHPKDHAAMYPIIEEFIQKSLPAWDLIYRWVKKFPVQRLTARKVGRGVSRPDVVPEEAAKQSEDDNDGEEHQNRELDGDTLGQLCSEETEGEKRKYYTSDGENSDESENPDDVDSEGEDYDDDDDDDDDEYDNSDIEEDDINKASPYFRISKKHVRSSGFFNRTPRIQVIVKLANIHLTPDKPSYDGGSWHIEGQLNEHICATALFYYDCHNITESRLAFRTPANVENLGQRLKYQQNDRASIERVFAIRSGFDTLQDVGSVLTRPGRSLFFSNLCQHRVQPFKLEDPTKPGHRKILALFLVDPAIPVISTSNVPPQQRHWYTSGGQSEAVATVLQNMDSIMVLDEAKKLREELMAERTVLQQNVEDELNQVEWSFCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4R4</accession>
    <name>A0A7D5Z4R4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PUP3</name>
        <name evidence="6" type="ORF">G6M90_00g097210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546620.2">
        <property type="nucleotide sequence ID" value="XM_014691134.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4R4"/>
    <dbReference type="GeneID" id="26241043"/>
    <dbReference type="KEGG" id="mbrn:26241043"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="205" mass="22389" checksum="6F0566E69B65F446" modified="2021-02-10" version="1">MSSPFSINGGACVAMVGKDCVAIACDLRLGLQALTVSNNFPKIFQYGDVFLGLTGLATDVGTVADLFRYKVNMYRLREERAIAPRTFANLVSSSLYERRFGPYFVSPVVAGLDPKTGKPFICGFDSIGCIDFAKDFIVSGTASEQLFGMCEGLWEEDMGPDALFETISQALLNAVDRDALSGWGAHVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4W6</accession>
    <name>A0A7D5Z4W6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g064930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540050.1">
        <property type="nucleotide sequence ID" value="XM_014684564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4W6"/>
    <dbReference type="GeneID" id="26247086"/>
    <dbReference type="KEGG" id="mbrn:26247086"/>
    <dbReference type="OrthoDB" id="10275639at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="451" mass="51502" checksum="67F948996C0782F1" modified="2021-02-10" version="1">MASTKRSYDTMANSHKTCVKIRDNILGGVELNSETKDFLQDLIQRHAPKLRDERSEIEGVDILSPGRFIITELSHVIFNMPVFNQSIRGRWNDIKRAATIFDQMKNELSHLVVPRQSLIRVDATYLIVEQRLPLGYTSCHEMAYAFNKDKLTPALAQLTKFIIWSGFRYAHPNTVPLLQLEVRPDGQYRIGLMDLGDCGSGTLSGRFFHDKTKKNMKYNKYKKHAFVRKRKFTRGVAKKSSMHLVKEDLNENIQYTLEVAFCRRLIQFVYPQHFDIIYKAALSEGVDLKTMFPSPEGWEQACNDRKLAIENGSLGLQLFSTIELCADINAQYFTGDSWKILQTVRTVRLKLDFDLDIPIRAFRTDCLIGVLFANKDSNVVSIILQSARHLDDAPAVLKSVLSEEGEVITSVKRMSPAEGLCLLVIEHDERLADFVKIHRESGFPITNGWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Z7</accession>
    <name>A0A7D5Z4Z7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic proteinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">YPS1</name>
        <name evidence="5" type="ORF">G6M90_00g097000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987588.1">
        <property type="nucleotide sequence ID" value="XM_066131521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4Z7"/>
    <dbReference type="GeneID" id="26241062"/>
    <dbReference type="KEGG" id="mbrn:26241062"/>
    <dbReference type="OrthoDB" id="4940641at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028817449" evidence="3">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="399" mass="43400" checksum="ABE334796CA92A69" modified="2021-02-10" version="1">MYFHRASLPLLGALSLSARAAPQSEDLTAQRPGIIQLSLKAPRARDKRQVDIDLTYTSNFKYDVEFSLGTPGQKIVGSFDTGSVYIWVREKAEASVNTAVAGARSYFDKSSSSTLVRTGESKTTGYNIGGNSSHQIDLYRDNMSLGDGGVLLGGVNRKKFWGRLGKQKMTVHPFHGKDYVISFNEVSATAENGSKSSLSRSDEGIPALLDTGTLLNKFPPSVFQSILKRFPGAKPMNKYPLYIVDCSLRDVNASIDLAFGKTTIKMPYSNFILSIEKPECVLVHTVLGQVFMRGAYIVMDQDNSEVYLANAVSCGSEPVAIDKDVSAISSLTGKCQPPVVEQNLLPWKRPGIDAENCVDAASEDVCGTAEYCRIFPGAFGSDFETEDDCLAAHEIPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5H7</accession>
    <name>A0A7D5Z5H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g054290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986821.1">
        <property type="nucleotide sequence ID" value="XM_066130580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5H7"/>
    <dbReference type="GeneID" id="26246281"/>
    <dbReference type="KEGG" id="mbrn:26246281"/>
    <dbReference type="OrthoDB" id="3452273at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29352" checksum="E3AD1D347B05AA19" modified="2021-02-10" version="1">MAPIVVPENKPEKRFYAGGARISAVRSNPPCSSHQPEDWCLLSQRNSLAQSIWRNMALAHLGRNHGKAEAWYILTPGSVWLVLKESIDSGELPQLVETGRGTNPLDRMQKFGLLPRQTLHVPPGTLHAISNGIVVVKIQGPEDLSVLCEWGGFAIHGKNGGHLGLEFPTALKAVDYVQVEQWVTSGVVAKSVLAAESTKHFGLERIHVEGSARTKRGFAILVVLDGKLLSNTSHSDPLPLSKGFTLVIPHEDDELSLQGEADVLIARPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z638</accession>
    <name>A0A7D5Z638_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tyr1_1</name>
        <name evidence="13" type="ORF">G6M90_00g050780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545180.2">
        <property type="nucleotide sequence ID" value="XM_014689694.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z638"/>
    <dbReference type="GeneID" id="26242521"/>
    <dbReference type="KEGG" id="mbrn:26242521"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="11">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI67569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="612" mass="69382" checksum="8C3B12CB430A80C3" modified="2021-02-10" version="1">MSYEYYPITGIPVQPGEVTPARRELASWSTSTVPGDQIQVSLFIRALQKMQDKNPLEELLSYFQIAGIHGYPVVPWDHATQHGFYCTHGSITFPTWHRPYMLLYEQVLYNIMDQELIPGITDTAVRQDWKKAAQQWRLPFWDWALPQSDTNKFGVPGIVGLEQLEILKLGGKDKESVKNPLYKYTNKINGEEVSMNDAKMKPYQLDYDAYGGIYNKSIGTSRYGNPSLPDWVQGFVDNAKIEEAMENPEAPHWQKGVSIAENVYRILTDVYFQSYETFSSTYLTDDKKNLKPTEYLSLEMIHNNIHVWTGGWVEGPATKVTGVPVTAGHMADVPVASFDPIFWLHHCNVDRLLAIWQYLNPDKWFGTEPPPTPGHTDITPLPTDDLPPFHINKQGKYYNSNDARDCGKLGYTYQDLVNTNIDKLKAELQDKYGNHTKKLLQPVKGIRPVPGVSEETFPDYIINVEYDRFALGGEPYAVKFHLETTNDQGKTESCTLGSFHNFTSPVVPDCKNCQNQKDKSAKSKAQVPITLPLHGIVKSTRFPDATSLEPVHVNVLLEQQLRISVTKLTGEQVLLTNLPGFHVTVHVGTAKQPSVSRHVFHPETYRTLRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6I6</accession>
    <name>A0A7D5Z6I6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reticulocyte-binding protein 2 a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g110060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543851.1">
        <property type="nucleotide sequence ID" value="XM_014688365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6I6"/>
    <dbReference type="GeneID" id="26243238"/>
    <dbReference type="KEGG" id="mbrn:26243238"/>
    <dbReference type="OrthoDB" id="5242628at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="46044" checksum="5CDA34BDC11F6F5F" modified="2021-02-10" version="1">MSYYSDDEDVDVRIRHHGHSPRPVRYVERPRNYYGVPAGPSYLVPEQHTTVVARSRSHDRSRDRRASPPSPVPAPAQPVIINNRFYGEHSSDDDDDYRRRRQVVYRRRSSDSRSRSRSRSRSRLTREEWEAELARRELERLRLENSRDREERRLTKEARDEAELKRAKMELDEIKQREARAEEEKRIKRELELKRLKEEEEEAEEKKRRHKEAAEAVERYKKLEADRMAAEKLRKEQEEKEYKRRMQEDLLKSGLDEKAISAILEKKKVSNAPERGHRPTYTRMARRHLSIETLRTFHIDFDIDNDPEYILIKRWVPEWEQDQFWRHTKYIREKRSSTLLIEEKKTHRHEPQFEWVRKKSDRKRSKSPGGLLMYLAGAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6S3</accession>
    <name>A0A7D5Z6S3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qa-4_1</name>
        <name evidence="2" type="ORF">G6M90_00g056150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544208.1">
        <property type="nucleotide sequence ID" value="XM_014688722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6S3"/>
    <dbReference type="GeneID" id="26242620"/>
    <dbReference type="KEGG" id="mbrn:26242620"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="39"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="365" mass="40458" checksum="B16A461A90079193" modified="2021-02-10" version="1">MSNGNSVTGEVQQQKRFLPSIATMSLGSSTLHPLDVKLKVAAAKGFLGIEMYWDDLVQYSLQFRPKPPSHAAHEAVAVLVAATNVANLAARLGLKILSLQPFRNFDGLADPGLREKRLDEFRLWLATARRLGADIIGVPSTLPTVSAADYTDNRHAIAADLAKLSRAAKAQGIRVAYENLCFAAHVRDWHQAWDRIELAREPDGLLFLPDTFNICGRTYMDPEAAGGRTPNAEADLRASLARLVDTVPMCRMPLLQVADAELPDEPLTQDHPWRKEAGLVPLMALSRNARLFPFEERGYLPVVSVIQALVGAGWEGWVSMEVFSRTTAVHGEETIWEHAERAWESWEKLARVMGWPARPRIDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z833</accession>
    <name>A0A7D5Z833_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump vrtL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">vrtL_1</name>
        <name evidence="9" type="ORF">G6M90_00g056630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544253.1">
        <property type="nucleotide sequence ID" value="XM_014688767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z833"/>
    <dbReference type="GeneID" id="26242665"/>
    <dbReference type="KEGG" id="mbrn:26242665"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF143">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="493" mass="54180" checksum="55B3E6A361D8A566" modified="2021-02-10" version="1">MAEKQPADNADLESAQPSTANTDSDTPKNVDPNLIAWAPSDPEHPRNWPRPTKWKTTLTVSLFVFISPISSAMIAPALEDLGRSLDMKGNVEVYLSLAIFILAYAVGPIFFGPASELYGRVRILQITNLWYLVWNLACGFANTKAELFVFRFLAGIGGSAPLAVGGGAVSDMWKPEERGKAMSTYTMGPMLGPVIGPIAGAFIAQYSTWRWVFYSTSIAAAVVQALGFVWLRESHPPTILRRRRDRLARETGNRDLYTGEKEETLGRTLLRAVQRPVRMFATQPIVACIAVYMAYLFGTLYLMFATFPDIWTKVYGQSKGVGGLNYLSIAIGCFVGIFLQLKMVDRVYGALKSRNGGVGRPEFRMPSLAIGSVVLTVGLFWYGWSIGHAHWIMPDIGALLCSVGVICCLQGMQMYIVDCYQTYAASAMAACAVLRSLAGFGFPLFAPYMYEELGYGWGTSILAFISIAIGWVAPVIFWVWGPRLRAMSKFASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z866</accession>
    <name>A0A7D5Z866_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">davD_1</name>
        <name evidence="10" type="ORF">G6M90_00g059350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544506.2">
        <property type="nucleotide sequence ID" value="XM_014689020.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z866"/>
    <dbReference type="GeneID" id="26242918"/>
    <dbReference type="KEGG" id="mbrn:26242918"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="52"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="525" mass="55989" checksum="9CB4A28F255A81A9" modified="2021-02-10" version="1">MALLQRIAAPTSKLRFSPSISLILARRASTMPPQLRDPSLLKQNVAYINGEWRAATSGETFKVNDPSTGTLIGTCAECDAQDTKLAIKAAADAFPAFRSLTGRERAKMLRKWYDLMVENADDIAKLITWENGKPVAEAKGEAAYAANFFEWFSEEAPRTYGDTIPATVPGNRVWTVKEPVGVCGLITPWNFPAAMITRKVAPALAAGCTVVCKAPGETPYTALAVAELGHRAGIPKGVVNVVTTLSNTPEIGEVLTTDPAVKKVSFTGSTGVGKLLMKQSSGTLKKLSMELGGNAPFIVFDDADLDTAVAGAIASKFRGSGQTCVCANRIYVQEGVYDEFVKKFTEKVNAFKVGNGFEAGTTHGPLIHDRAVSKVEAHIKDAQSKGGKVVAGGQKMPDLGANFFQPTVIRDMTPDMAMATEETFGPVAGLFPFKTEAEVVEMANKVEVGLAGYFFSRDLHRVYRIAEALEVGMVGVNTGIISDPASPFGGVKESGFGREGSKYGIAEYQVTKMITFGGMGSPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8A0</accession>
    <name>A0A7D5Z8A0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyketide synthase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">AUSA</name>
        <name evidence="13" type="ORF">G6M90_00g052600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Polyketide synthase; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540387.1">
        <property type="nucleotide sequence ID" value="XM_014684901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26246749"/>
    <dbReference type="KEGG" id="mbrn:26246749"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000017">
        <property type="entry name" value="Non-reducing polyketide synthase aptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="403"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1331"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1717"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1655"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1795" mass="195542" checksum="61179C3F8C161511" modified="2021-02-10" version="1">MVIHTPNTISDSDGELCKMNFIYFSNEFPKGDLQDLLRLLHSHSKDKHHPVLAQFIDEATRAVKDEVRALPSELKDLIPSFTTILSWAEDGGLREGLICGAVDGVLLVVVQLAAYIGYTESHPEESVDVSNSGLLGLGIGLLASTAISLSSTLSELPLAGADAVRLAFRLGIHVLSVSENLEARDVSQKEDSWAYVVHNVDPVAAQNELDIFHSRLNTPSTAKIFVSAISQNSVTVSGPPGRLKGLFNKSEFFRVSRCIPLQVYGGLCHAPHIYNQQDIHAVVYGSSLNTIVSKARPALLVYSTRTGLPYTANNAAELFECVISELMTKAICWDEVIRVVVDQVQCAGPRGVVLNCFGNSIPLNDLNLALTSTLPDCKLLIKDFIPWLSLAAPRSNTPRGAAQSKLAIVGMSCRLPGGATSTEKFWDILEKGLDVSRQIPADRFDINTHYDPTGKELNKTMTQYGCFIDEPGLFDAPFFNMSPRESLVVDPQMRLSLVTAYEALEQAGFVANRTASTALPRIGTYYGQAADDYREVNQGQEVGTYYIPGGCRAFGPGRINYFFKFAGPSYSIDTACSSGLAAIEVACQALWAGDVDMAVAGGVNVLTNPDGFAGLCNGHFLTKGHNACKTWDATADGYCRADGVGSLVIKRLEDAELDNDNILGVILGAGTNHSAEAVSITHPHAGHQAYLSRQVLRQACVNPLDVSYVELHGTGTQAGDYEEMQGIMDVYAPLAKRRSKDKPLHIGAVKANLGHGESVAGTTALIKVLLMLQKNAIPPHIGIKTEINPKFGRDIDKRHLKIPLEMTPWPHVPGKKRIAAVNNFGAAGGNTTMVLEEAPVRPADETDPRQTHVISVSAKTRSSLAGNIESLLGFLDKNPNTNLGNLAYTTTARRYQHTHRVAIAASNITQLRKQLTSRLDQIDSIKPVAKSGPPPIAFTFTGQGASYKSMSLELYRDVPTFQHHIRHLDSLSQSQGFPSFIPALDGSHPKEHEHSPVVTQLALVSTEIALAKYWASLGVKPDVVMGHSLGEYAAMHVAGVVTASDTLYMVGKRAQMLQEKCESGSHCMMAVRASLEEIKARSEGKPYTIACINGPSDTVLSGTKQQIDEVSILLEQAGFRCIKLDVAFAFHSEQTDPILDDFEAICKSGVTFQEPKLPVISPLLGKVIFDGKTLGANYVRRATREPVDFLSALENAQRVSTISDETVWVEAGPHPVCTGFVKSIIPATQLAVPSIRRGEDNWKTMAESLAALHLAGIPVRWNEFHRPFEVRLRLLHLPAYSWNNKTYWMQYNGDWCLTKGNNFYETGNDATKAKAALKSPPPSELQTSTVQQIIEESFNGSAGSVVMQSDLMQPDFLAAAYGHRMNDCGVVTSSIHADIAYTLGSYLHRKLLPKAKQANMNISNLVVTKGLVANSDTKSPQLIRVTASTVDAHSGVVDLTWQNVDNNGYVHEPFATANIIYGDANEWISSWNPIAHLIHSRIETLERLAVEGRASRFSGNMAYTLFASNLVDYAEKYRGMQSVVMHQLEGFANIELTTKEGGVWTVPPYFIDSVAHLAGFIMNCSDAIDTKNNYCVTPGWNSMRFAKPLVPGAQYRSYVKMIPTVEDPTIYFGDVYIMQDDMIVGMVGGIQFRRYPRILLGRFFSPPDKAAAMEGKQGIVAPQPKTTRPALKSAGPERDHGKNNLPPVKPAAEVADEPSKDKLPPTSAGVPAVESATGSNSVASKALQVIAREAALEVSDLEDDASFDNLGIDSLMSLVIVEKFRIELDIKVGGSLFLDYPTIGDFRKWLEEYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8A2</accession>
    <name>A0A7D5Z8A2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986938.1">
        <property type="nucleotide sequence ID" value="XM_066130901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8A2"/>
    <dbReference type="GeneID" id="90967910"/>
    <dbReference type="KEGG" id="mbrn:90967910"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="123" mass="14103" checksum="06FAA0CFC54B4F43" modified="2021-02-10" version="1">MNCFLCTGYRSTQRSKAKKPTPLQLPHHSLEVTRPPTPYPFHCSKQDRRVCNPTREQNNDSNDKNKLNMNGLWKSPESVNINNAPILEIPETGDIELGYHIDAAGKDVTDMMEQLDIRRIRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8P4</accession>
    <name>A0A7D5Z8P4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="primary">trp-1</name>
        <name evidence="20" type="ORF">G6M90_00g087020</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542416.1">
        <property type="nucleotide sequence ID" value="XM_014686930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8P4"/>
    <dbReference type="GeneID" id="26244930"/>
    <dbReference type="KEGG" id="mbrn:26244930"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="28"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="249"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="581"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI71606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="760" mass="82768" checksum="112B9029F9727BDB" modified="2021-02-10" version="1">MTTPALIDHSPHQPEPSPPVATASNLILIDNYDSFTWNIYQYLVLEGATVHVFRNDQITVEELVKKNPTQIIISPGPGHPTTDSGVSRDAIRHFAGKIPIFGVCMGLQCMFDVYGGQVDSAGEWLHGKTSPLTHDSKGVFAGLEQGLPVTRYHSLAGTRLTLPECLEVTSWVAKDDGSQGIIQGVRHKKFAMEGVQFHPESILTAHGRTIIKNFLHMQGGTWEENAQLQKPAATNGTTTASLPKKNNILQRIYANRRAAVEAQKQIPSQRMSDLEAAYGLNAAPPQVPFLARLKQTPFDVALMAEIKRGSPSKGIFALEINAPVQARKYALAGASVISVLTEPEWFKGSIEDLRAVRQVLDGMPNRPAILRKEFIFDEYQILEARLAGADTVLLIVKMLETELLERLYKYSLSLGMEPLVEVQTAEEMEIAVKLGSKVIGVNNRNLESFEVDMDTTGRLRKMVPESTVICALSGINSHKDVLACKNDGVNAILVGESIMRAPDATSFITELCSGSKPTEKKRQPKPLFVKVCGTRSPEAAKQAVESKADFVGIILVPGTKRCVSHETALAISEAVHASGDNLADRKEEPVPKSGAADFFAAAADRLQSSRTRLVGVFMNQPLSEVLEKQRLYKLDMVQLHGEEPIEWAKIIPVPVIRSFKPDNVGIGLRGYHTIPLLDSGAGSGKLLDVSKVKAALERDPDLRIFLAGGLNPENVTEAVKALGDLSDRVIGVDVSSGVEEGGKQSLEKIDAFVRVGKAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8R9</accession>
    <name>A0A7D5Z8R9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SRP72</name>
        <name evidence="12" type="ORF">G6M90_00g088820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542233.1">
        <property type="nucleotide sequence ID" value="XM_014686747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8R9"/>
    <dbReference type="GeneID" id="26244747"/>
    <dbReference type="KEGG" id="mbrn:26244747"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="549"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="646" mass="70160" checksum="77FEFE4A18C808CD" modified="2021-02-10" version="1">MPQDPATTLSAMLRGATIDDHDEILKAANAALKANKNDELAQNTRVVALLKLDRFSDACRAISEGGIKLEANCVLERAYALYKLGKLDDATSVLASMGIQKRSLSHLAAQVAYRAENFDEAQSIYNRLLASDPDEEANDLSINLQAAQAQAAWKDISTSIVPDSEKTMEAFELCYNAACANIARGSLQLALKLLQRALALCDASDELTDEDKEEERKPILAQQALVLAKIGDLNRARDIYSSIDISAESEPDFKIITQNNRWALEKKPENPFLVEREVASWMSASSKAKLFKFQSDVLARNASVVDLRAHKVNGVKERVKKATTKDQMPSCNADLNGMSVIGAAAETQGLARKDALRSLLSLSKARPNDTGLVLTIVQLHLERKKLGAALHTLMSFFSRLEGSGDEQSQRVRFSPGLVALAVALKKTQKRETSARAELVRAAEFWRERPTTSVVSLLEEAGIALASSSSRNELNLARVAFTKLHHEKQVPPITSAGLVAAVAASDVSAVEQHIAQLPSVESLVSGIDVESLINSGVASTVEASAASRKRRSPTAPSSERPSQRRKRIRLPKNFVEGQTPDPERWLPLRDRSTYRPKGKKGRKKVAESTQGGVVKEEETLGLVGGGGVKVEKASASSSSKKKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8U5</accession>
    <name>A0A7D5Z8U5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitosis inhibitor protein kinase wee1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">wee1</name>
        <name evidence="8" type="ORF">G6M90_00g077010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545401.1">
        <property type="nucleotide sequence ID" value="XM_014689915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8U5"/>
    <dbReference type="GeneID" id="26241434"/>
    <dbReference type="KEGG" id="mbrn:26241434"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000611">
        <property type="entry name" value="Protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="718"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="630"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1084" mass="117357" checksum="BF91BF3A27A6E1D0" modified="2021-02-10" version="1">MSFSNGGGTLALPSPTHAHHMDVSSAVRSLRRSISRSPSKFLSRTSSQSSDSSRQASPQSPCRRFGATPQRQYISPSQPQTAPPAITSTHASTPHQSSVLTPLRPSVRLSLRSAKSAKTTSTSSRPLARARASPKSPLKRAFSAAPDSGNPGQPSVTSSPTSATPRGQDNKSSPRSAHSPGEKPSRHSFHLDVSGSSQYAALKALETPSSESYMVSTTGALKRSDATMNLDYPNQGSPASKRRSLHGVASFGPSGEFNIFGANTSSSQSFDIHEDPHASEYELTGANNGLVNSNREPLSSPSPVANLPRRSSSLRKSTLQQRYGEKGSWGRRTGERQLAQMGGDNSTPVRNRPRLSTDHFLPPPVPRDSPFNAGSPLPNASIHPLDNKGQHQPHPLSKTLTTSTSGNSLTEEPSGYAPGPKAADRPRPHIFSRSLPLNATRPTARSTNDHTKAVATPSRSHQLWIAAFNSTGLISKVNRNPEEEADRKLAPPDTPCKKHTNPFATFPPPVGSAIKRKGNSRNSFAGLPSTPFHSSSSRAPDTFGQPAKGLSIFQRGSASHSSRRGSILSLEGEDRKLFCDSNELPSISDGDIPPTPTKTTTLTTSLSNLSEQSLESPSANRTFILPLSAVKPAASRESTRSPVDGRRTPQTPQESLLPLDTSRLSISQAPDNVNDNTMPPPVTPTACRDFRSSTSIFVTPVNARTSSLDIDASLYSRFDKVEQVGKGEFSTVYRVTKLEHVSAFMLGNTTPSHSASRSPAKGQVFAVKKSRHSYYGHKDRETKLREVRTLQALTHAEHVVQYVDHWEDNFHLYIQTEFCEEGTLEKFLGNVGRGGRLDDFRIFKILQDLCLGLKEIHHAGFMHLDMKPANILITFEGVLKIGDFGLAQPCTSTEGVDVEGDREYMAPEMLKGKAGQSADVFSLGLMTLEAAANVVLPDNGPTWIALRSGDLSEVPSLTWTPSLEVQRDAIGNPTESAHSDDLQEGKTRSASNLFGSFKRSELQQAPEFMLEAFHPSSLDSIVKWMTAQEPAARPLIDQVLELEGLRWVAEHRNAPATVYEGNWGPAEMFPVSIANDSDTEMTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z961</accession>
    <name>A0A7D5Z961_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-xylosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g085980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541157.1">
        <property type="nucleotide sequence ID" value="XM_014685671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z961"/>
    <dbReference type="GeneID" id="26246146"/>
    <dbReference type="KEGG" id="mbrn:26246146"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="3">
        <location>
            <begin position="194"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="4">
        <location>
            <begin position="506"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="801" mass="90402" checksum="A48A96F926B7DD0E" modified="2021-02-10" version="1">MDKYAFPCDPLANPAAVISGPTYRFTLLGETVLRYEWAEDGVFEDRASAFAINRNFTPPEFTVNDTEKHVEVVAHNFHITYDKRRFSRSGFTIGFPSKVTLWGADWHYGETAKDNLGGTARTLDEVDGRCDMGDGILSRSGFATLDDSDTMLFDGQGFIAPRKSGDRIDGYMFVYGHDYKGAMKAFYDISGRQPALPRWALGNWWSRYHPYSADEYIQLMDTFAKRRVPLSVAVVDMDWHQVKGDHIPHAGWTGYSWNKELFPDPSGFGKALHDRGLKITLNDHPHGGIHHHEDLYETMAKAIGHDTSKKAPILFNPTDPKFMDAFLSVLHRSIEKEACDFWWIDWQQGPISRIPGLDPLWLLNYFHFQDHVNQNGEGKGIIFSRYAGPGSHRYPVGFSGDSIRTWESLRFQPEFTATASNVGYGWWSHDIGGHMGGIRDDEMATRWVQYGVFSPIFRLHSSYSQWTSKEPWNFRAEHCYAMEHFMQFRHRMVPYLQTTNLLGGAEPLVRPLYWEYPARSEAYEKPNEYFFGPHLVVAPIVHPRNPATNLASANVWVPPGRHVDIFTGAIYDGDREILMYRSIETIPVLAPEGSIIPLEADLFPQNGCMNPTSLEVIIVVGKDGGFAILENPHDDADAEPSRENGDSIEYRKIKLDYKQSTGRLSVSESTKTWKFKFLSLMSIPPALKVHVSGVVTTCKIHVEDMPDTPGLVVEIPAQNPNHKVDVQITLGPEPQLSMLDRSARLKSWLLDFQIEFAVKDKILAAVEGNKSLASKIGGLMSLGLEADYTGPVVELLTGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA47</accession>
    <name>A0A7D5ZA47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g098960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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            <strain evidence="3 4">4556</strain>
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        </source>
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            <strain evidence="2 3">4556</strain>
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        <source>
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    </evidence>
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</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
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    </dbReference>
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        <source>
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                <person name="Kortsinoglou A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
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        <property type="protein sequence ID" value="QLI71949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541790.1">
        <property type="nucleotide sequence ID" value="XM_014686304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBD5"/>
    <dbReference type="GeneID" id="26245258"/>
    <dbReference type="KEGG" id="mbrn:26245258"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="283"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123981" checksum="26B210A2FD19F8E1" modified="2021-02-10" version="1">MFSNFTSIVQKAQQLIDPTQGLNLSSSDRNPSKASLFQNQFRLPSSQNPLYEINAELTIPPSNATQGDRDHDRGWHYPGKLHLSESYMCFSTTPTSFVQTATASTSLAFTGPTHGAGPSGNGFTFPLCAIRRVERLNSQNFQFALAITTWNGLLADNPKDKDSSKDIKDAKEQRITIHLAGSRPACERFCDGLKRGLRAGVGNVGKLRKVVAECYSEHLLRSEEKKNSNPPDAGLGMVFRYPGDPKKLRDRAKMRLWAEYLRDNGRNSTLIRQPTFHKLIRVGLPNRLRGEIWELTSGSLYLRLEKPTLYADTLTKFEGQESLAIDEIEKDLNRSLPEYPGFQSEEGIGRLRRVLTAYSWVNPDVGYCQAMNIVVAALLIYMSEAQAFFLLSSLCDRLVPGYYSTTMYGTLLDQKVFESLVERTMPILWEHLVKSDVQLSVVSLPWFLSLYINSMPLIFAFRVLDVFFVEGPKVLFQVGLAILRINGEELLDAADDGAFISVLKAYFSRLDESAHPKSENPKLRAVTRFQELMVVAFKEFSGITHSSITELRLKKKDAVLNNIENFAKRTAIRNLGPDSKLLNTDELGALYDRFYSVLYERQQRDLMIQEEQKRRAKTSRMRASEIFSSAPNQVEKGRVGLGPSTSLMDYDAFREFLASMCKWALSDSPGNSRRDTMAGGDKSPKFNTARKSPDLTSPWGVGPEPAEHEFLQRLYKKWDVDGNAALTLQNVVTGLAGIKGKRDIMGTITYFFELYDDDGDGKVDREGILRISEALLFLSRRGLEGTLSPNASSLALNGETGSANESQASLPAGIPVNERFLGSVSAFIRRCFEYADPDHPQNQNTSNTPQDAEADQNSFAIGDDEDEEDLLELESPSGSPKEAKKTNEMLLDGEVPADGTNDESRRKVSKAKSEAANAALNPAQPLHMTLPTFRMVVLADELLEQFFESSFPFSFHIIEGLQSAAVTPQSSSLTTFASLGFGSKPPLPVQPGPHGAGRGLRGVLDNIVTDGMRVATEVRRRMEEAQKELEKNALPGQRPEDDEEDDDDIGIAVGARKGPGGPSGDNRSVKSSDRDLLDGLDAGAGASSKEQDQDLIDVNSGEGRPRVETVAASGTGVVEFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBG8</accession>
    <name>A0A7D5ZBG8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g099930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546356.2">
        <property type="nucleotide sequence ID" value="XM_014690870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBG8"/>
    <dbReference type="GeneID" id="26240779"/>
    <dbReference type="KEGG" id="mbrn:26240779"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="289" mass="32026" checksum="756E38E3C80D2BB1" modified="2021-02-10" version="1">MALKLFYVAQIFYKITINLTKASIVLLYLRIFLQRWFRICCYILLGLFVAYMIGTVAASIWQCSPIKGAWDKSMKPTCISLTKNWYANAGYSIATDVLVLCLPMQPIWTSKLPVNQKRALMLVFALGGFVTITSIMRATTLSFSTKSPDPTYDITSTLWTMIEENVAIICACLPMCRIVLAWIFPKAFSTLSTAASGGEGSGGPAYTIGSAPKQLSPSHSDDDWQPYSGPAKCEGQNHSIARHRLEDGSSEEFILQSVPKPATLEMAGAAIRKTTHYEISYERNPYNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCA3</accession>
    <name>A0A7D5ZCA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g108200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544025.1">
        <property type="nucleotide sequence ID" value="XM_014688539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCA3"/>
    <dbReference type="GeneID" id="26243412"/>
    <dbReference type="KEGG" id="mbrn:26243412"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028963376" description="LPXTG-domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="55825" checksum="1681CF57B9C83890" modified="2021-02-10" version="1">MELPAVTLLLLAIAGLTTALEVTPGSRCAVECLDSPGGNDFSASDSTTTVDDISCKDLDYSTTDAGIKFRKCLDCLQHSKKVDKTESDLKWYIYNLRYTLTTCMYAAPKAVKNGTVAAQCNVDKACMAMKEPLIEPGFNANPNTTWDYCTANNGAFMGPNLSPCISCLQATEGEAYLSNFLAALEAGCKQAPEDGAVLSLSGSVFTTSPINTTDPSANDQANQSSGSLSPSAIAGIAIGVFLIFLLAAALLVVHFRRERSWNEWEQSCYYSNFPPPAAYTEQPMSQAYRRYYTGNAFSEKAHPAQPNSSGEYYDRVEAELAAAARQNKQANSAPHSHVSSSPTIHNQDETLPASSVCRSRSFGHVSRARTPSPPAETHTHRRSNTPDSFAVQAYLNAAEDSARLAARKSIHPTSYAPEPQSKRTPAISTPYLPYMPKLRIPKIFINREGPRDVRQMQISPPLMTHDPRFHDIPMSGPVAMSRDRPPPPLASVARQDGYIEVPLRSGKSTLYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCH6</accession>
    <name>A0A7D5ZCH6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g112680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540335.1">
        <property type="nucleotide sequence ID" value="XM_014684849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCH6"/>
    <dbReference type="GeneID" id="26246929"/>
    <dbReference type="KEGG" id="mbrn:26246929"/>
    <dbReference type="OrthoDB" id="3930719at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="202" mass="22995" checksum="E02D9133FBF97CB3" modified="2021-02-10" version="1">MADTKASRQPVTGSCHCGTIKYVAFLTLPQTHNESNPPTKQEQRIYRCNCTMCHKAGFFHVRVANKTDDFLLLSPLDPLQELGDYLIHNKVLHWLYCKTCGVRCFTFMGTGEVVDLDLAELCVPGYTDKGQKTRVWRAKEDGGHPEYGTYLSFNGNTVDASSKSFDMREMVEQKCVQFYDYLAEGEKRQPVRYGRPHQGGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPW4</accession>
    <name>A0A7D5UPW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pex7</name>
        <name evidence="12" type="ORF">G6M90_00g023560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548199.1">
        <property type="nucleotide sequence ID" value="XM_014692713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPW4"/>
    <dbReference type="GeneID" id="26237643"/>
    <dbReference type="KEGG" id="mbrn:26237643"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI63472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="353" mass="38368" checksum="F9C68D2F8699E5B6" modified="2021-02-10" version="1">MAAMLEFRTQGYNPYAVKYSPYYDSRIAVATSANFGIVGNGRVFALGLTAQGVQVEKTFDTNDALYDLAWSEINENQLIVAGGDGSLKLFDLGVNEFPIMNFHEHKRETFSVCWNPVTKDTFISSSWDGTVKIWSPTRPHSLKTLPIGNCTYSTSFCPSNPALISAVSSDSHLRVFDLRTPTSAKYHLVSTIPVHAAGAQPGVNPGLAAGSPPAEVLTHDWNKYNDTVVATGGVDRVIRTFDIRNPTAGPLGLMHGHEYAIRRLAWSPHASDVLISGSYDMTVRLWNDGSAQPSGPLAGAKPGHQLGVMNRHTEFVTGVDWCLFGAGGWVASVGWDERVLLWDSNMLMGPGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ04</accession>
    <name>A0A7D5UQ04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g008240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549683.1">
        <property type="nucleotide sequence ID" value="XM_014694197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ04"/>
    <dbReference type="GeneID" id="26239127"/>
    <dbReference type="KEGG" id="mbrn:26239127"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38609" checksum="5B73022691BDBFC4" modified="2021-02-10" version="1">MGDSDQNKKPVAAVPAWQREASAENAIEPEPPAQQTDYHQQLQIARRFLDEDPVKSASPAKKAEFLRSKGISEGDVEKLLGHSDVDPESSSSQNDTPESGSTQTTSVLHNSATLSAASDRPPIVTYPEFLVKPERPPPLVTKNGIFNTLYAFAGLSTVLYATSKYLIAPMVENLTDARTELHDVTYKRLDNLVAQLEKTVSVVPSTTSKPTSSEDSDGSDAEDPTEMFHRDIGTQTSLIDQNATPAPKESEPTSKRHADTLTSLTKSLSILKDQYRAQSEGFEDVKTLLDLLRDDLDGMTYGGYTEFVGGYDIYGSAKRNEPEDEIRKVRDNIRRVKGVLLSTRNFPASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQD5</accession>
    <name>A0A7D5UQD5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vps55</name>
        <name evidence="7" type="ORF">G6M90_00g020730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548474.1">
        <property type="nucleotide sequence ID" value="XM_014692988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQD5"/>
    <dbReference type="GeneID" id="26237918"/>
    <dbReference type="KEGG" id="mbrn:26237918"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034424">
        <property type="term" value="C:Vps55/Vps68 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="129" mass="13979" checksum="D70A7C564DD5406E" modified="2021-02-10" version="1">MPTAGLKTIISLSFVLAVGFLLVILSCALYQSYFPLLVVATYVVAPLPNWICSRCANPDDFVESSGAAVLDLGRFLTGFLVVMGMALPIVLAHSDLIRVEAMVMSIVGGLLIYGTIISFSLFFHEEQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQL4</accession>
    <name>A0A7D5UQL4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g029750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQL4"/>
    <dbReference type="GeneID" id="26245832"/>
    <dbReference type="KEGG" id="mbrn:26245832"/>
    <dbReference type="OrthoDB" id="5278984at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="33"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38451" checksum="F6C69857F5788BB4" modified="2021-02-10" version="1">MASEMNTSPEYTGYRLEVFIAVFTPLTIIAVALRFYARSLTSKKIDSGDWLIIAALVGQIVAGGIAIGAVKQAGVGHHAAYLAETNPETLVAFFKYLVAMSTWYATTEGLAKLAVCILYKRLFPQRGIHMVINTTMLVLVGASVGGGLADLFGCTPFSAHWGTAEEQAAHCVDTEALFVWGSFPNIVTDVVLLVLPMPIVWGLHASVRLRLVLVLTFLFGSIGLITSVLRFIAFYNKSSFIDPTFHAVELIIWTVCEPGVYLIAACLLVYRPLLEKIGIPLVGGVSSRGGNRQGPTELAFQKPSRPHNGAAIKSIGSGSISESGFEYIGDDDQRPLRRQGGITATTNVEVTWAAGSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URI2</accession>
    <name>A0A7D5URI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541367.1">
        <property type="nucleotide sequence ID" value="XM_014685881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URI2"/>
    <dbReference type="GeneID" id="26246002"/>
    <dbReference type="KEGG" id="mbrn:26246002"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31192" checksum="98F6D7A89909A73B" modified="2021-02-10" version="1">MALKNVFSFATQPFDPTNRFATSWLLPPWMLLACRALISVYIFTTLFFIMGYTCAHASLGGCLTVRRSFSYFTVITYWGLGFYFAAASVHTLTYMVRGGRPLLASFPRPLQALHSLFYTSIVTLPFLVTAVYWAVLYKAPWFELPFDGWHNVSQHALNSLFALFEVLAARTEAMPWVHLVWLIAILLGYLGVAFITLATQGWYTYSFLDHDKVGGRGYVAAYVFGIAVGIVVIFVVVWAVVWLRKWVTEAKMGRMGRFVVERRVDVEMSPVKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URZ3</accession>
    <name>A0A7D5URZ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g008710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549639.1">
        <property type="nucleotide sequence ID" value="XM_014694153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URZ3"/>
    <dbReference type="GeneID" id="26239083"/>
    <dbReference type="KEGG" id="mbrn:26239083"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="489" mass="52852" checksum="75AB235FF7F4D594" modified="2021-02-10" version="1">MAKVVKWRLLNSSPSPSRRVNSGGTPVTTPQAMSRQAYMSRREDGVSAPCAPSPSPGYVLEWSAKDSRAQRHRRILPSVEELRAELLAGEGGRSQGRILVLRAGRVDGAVREALVSVARVDGGFIDAHAAGTPYRPRGGRRTPRRWWTCAYPEVAAGKGQVPLYRPGDGQALTISRMSVWLGGGGVPVVIVGDGAGPERRDHKLRREQGAAGYGAIGSARPGSTGRVEMSSFEQDLWEALAPPDEVAVEEVLGEVVLDRWTGCLAAMRPGTIGGGAGHMQERESLWAAMAALESNLDEARRFSGRGRQLGAAGASAWADLLRRLEMRVRLGQQGIGAEASPARGGKTDNDRSLDRIAYLGGLMLPVSAVASILAIGGDYGPGGESFWVFWLSSFLASVLAVLVIYADQLRTVEVWLETGELDGELLPWEGEGSEEHLVQRWADGSRRAAWERRELGWGGAVKKMSGYYWWRRDPGLAFRRPRGVKLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US82</accession>
    <name>A0A7D5US82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS siderochrome iron transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MFS2_2</name>
        <name evidence="9" type="ORF">G6M90_00g010420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549476.1">
        <property type="nucleotide sequence ID" value="XM_014693990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US82"/>
    <dbReference type="GeneID" id="26238920"/>
    <dbReference type="KEGG" id="mbrn:26238920"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="580" mass="63727" checksum="90F706F59DD064EC" modified="2021-02-10" version="1">MGLVSKAQPVAMAVSANPEKPENNVCDSESTDATGNRLNRGKVQSGVARIEATTKIWSKSHLITAYAMIWFLYFVKSIEEVVVFSMDPFVTSAFNKHSITPAIQIVAIIIGGLSYIPLAKILDTWGRPQGLTLTVFIWVIGLIMMAACNNVETFAAAKVFNAVGSQGVSYCVTIFIADTSSLLNRPLMLAFATSPYIITTWVGGPVTESVLAGPGWRWGFGIWTIITPVVILPLSFLFLYNDRKAVKAGLIERRTGWITPRDVWDYIIAVDLAGIMLLAGGMALFLLPFSIWSYQAEQWRSPLIICMLVFGAVLLVAFVLWEKFLAPVSFIPYELLLDRTVFSAGVSFVFIYASGSIWRGYFYSMLLVVWDTGITKATYISNIYRVGSCFAAVIIGLIVHKVGKFKWVSTYYALPLTILGVGLMIKFRQASEDIGYVIMTQIFVAFAGGPMVVAGEMAMMAPSDHQHVAVIMAMLNLFCSIGSAVGSTISSAIWTGTFREELINNLPPGSPIDEIYGQVRKQASYPVGSEMRNGISAAYSQTQRYMLITSVCLLVVGWGCTWLWRDIKLSKIKQVSGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USI3</accession>
    <name>A0A7D5USI3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g027850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541374.1">
        <property type="nucleotide sequence ID" value="XM_014685888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USI3"/>
    <dbReference type="GeneID" id="26246009"/>
    <dbReference type="KEGG" id="mbrn:26246009"/>
    <dbReference type="OrthoDB" id="4961234at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11799" checksum="734063FE9B37544D" modified="2021-02-10" version="1">MGRMGKHNVVIAVFPDGEYSTSSAAVIARDMLHSFPNVRIGLMVGIGGGAPTAYQDVRLGDIVVSAPENRNGGIFQYDFGKTIQGERFHTTGLLNQPPVVWLLSTAVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT39</accession>
    <name>A0A7D5UT39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UBA1</name>
        <name evidence="14" type="ORF">G6M90_00g019260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986115.1">
        <property type="nucleotide sequence ID" value="XM_066129829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT39"/>
    <dbReference type="GeneID" id="26238059"/>
    <dbReference type="KEGG" id="mbrn:26238059"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
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        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
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        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
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        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBA_E1_SCCH"/>
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        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
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        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="900"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114850" checksum="08045EF196EC86D5" modified="2021-02-10" version="1">MTGTKLPEVDPMTRMQVDESVVGHTEIDESLYSRQLYVLGHEAMKRMGASNVLVVGLKGLGVEIAKNIALAGVKSLTLYDPAPVHISDLSSQFFLTPADVGIPRHDVTAPRVAELNAYTPVKIHESTGLDADLSQFDKYQVVVLTNTPLQSQKTIGNYCHSKGIYVIVADTFGLFGSIFCDFGENFTVIDPTGETPLSGIVAGIDEEGLVSALDETRHGLEDGDYVTFSEIEGMEGLNGAEPRKITVKGPYTFSIGDVTGLGQYQRGGMYQQVKMPKPINFKDFTASLKEPEFVVSDFAKFDRPQQLHVGFQALHAFQLSKGRLPNPMDDDDATVLLGAARLFIKEEKLEVELDEKLLKELSYQARGDLSPMAAFFGGITAQEILKAVSGKFQPIKQWMYFDSLESLPTSTKRSPELCKPLGSRYDGQIAVFGAEYQEKIANLTQFLVGAGAIGCEMLKNWAMMGLGTGPKGKIIVTDMDSIEKSNLNRQFLFRAGDVGNMKSDCAAKAVQRMNPDLVGHIQTFKDRVGPDTEGTFDEAFWESLDGVTNALDNVEARTYVDRRCVFFRKPLLESGTLGTKGNTQVVLPHLTESYSSSQDPPEKEFPMCTIRSFPNRIEHTIAWAKEYMFEKCFVKAPQTVNLYLTQPNFMETTLKQGGNQKETLETIRNYLTTERPRTFEDCIAWARMQFETEFTNKIQQLLYNFPKDSETSSGTPFWSGPKRAPDALKFDPNNPTHFGFVVAAANLHAFNFNIKSPGADKNIYLRELENVIVPDFTPDANVKIQADDKEPDPSAGGSDDEDELQKIISSIPSPSTLSGFQLQPVEFEKDDDSNHHIDFITACSNLRAENYKIEAADRHKTKFIAGKIIPAIATTTALVTGLVVMELYKVVDGKNDIEQYKNGFINLALPFFGFSEPIASPKVVYKGPEGKVTLDKIWDRFEIGDVTLQELLDHFKAKGLTIVMLSSGVSLLYASFHAPAKMKERLGWKLSQLVENISKKPIPEHQKEVIFEMVAEDMDEEDAEVPYIKVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTK2</accession>
    <name>A0A7D5UTK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g016280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693414.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26238344"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14022" checksum="1D57327C0B18CADE" modified="2021-02-10" version="1">MSSQSQGIKLIHNPDSSGYRLLELPPDLANLLESDTAPVLTLESSDSSTVLRTPSKTYNLRQKNTSNGLYLLAPHSPSDLPDQELAVISIIHETVELDVVPEMPVRRDKLADTGSRGKWHEMFGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTP5</accession>
    <name>A0A7D5UTP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NPS1</name>
        <name evidence="8" type="ORF">G6M90_00g008290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549678.1">
        <property type="nucleotide sequence ID" value="XM_014694192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239122"/>
    <dbReference type="KEGG" id="mbrn:26239122"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="625"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1800" mass="197273" checksum="714FC22AA5CC1DFF" modified="2021-02-10" version="1">MKSFILDALSSLSAFSKRRKQRKKGIAGDASTGIAPLAAPQHAAANPDINAPDKPEPVSDEKKGLGDRDLDQIWNWNRELPPLIQRCMHDIIREVSQRQPHAVAVASWDGTLTYQEIDALSTQLAQQLRRRGVSVGTRIPLCFEKSIWAVVSLLGVMKAGATFSLTDPSQPEARLRTIVDQTEAEIIVTSAAQRELGVKISRNGQVMSVSRDYFDQISSQPEESLPLVPSSSPMYIIFTSGSTGKPKGVVISHENYTSGALPRAEAVGYKSHSRVFDFPSYAFDVSIDCMLCTLAHGGTVCVPSEADRMNDLSGAIRKSKANMVHMTPSVARVLDADIIPSLDVLGLGGEAVSSSDAAAWSQDTSLVIAYGPSECTVGCTINNTLAISRGIGKGVGGTTWITDPEDHNILMGVGEVGELLIEGPVVGIGYLGEPDKTAEVFIENPAWLTAGHGDHGGRKGRLYKTGDLVRYESNNLGSIEFVGRKDQQVKIRGQRVELTEVEHHLQSCLPRGIKIAAEVIKPENSGAPTLVAFIAEPSSGSNETADEFPLVEPSEQLTAALSTVDKDMGAKVPRYMVPTAFFTLQSMPTLVSGKTDRKKLRAIAASIPREKFSGAQNGTAQVEQEPQTETEKKLADAWKKVLGSDVKANRGSNFFGVGGDSLRAMRLVAAARENGLSLTVADIFMNPTLETMSSRATDISLSDSNADKIAPFSLLNKDWAVGSVRQETAALCNIEADAIDDVYPCTPLQEALMALSAKVKEAYIAQRVVELEDAETATKLITAFDAAQGDCPILRTRIVQVPGRGLVQVVVKGKLSYFSGTDLDEYLVSDRDEEMDLGQPLVRYAVINDGKTGKTSFVLTMHHALYDGWCMPLIVDRVNKAYMGQTVERPAEFRHFIKYLCGTNKKDSEQYWRQQLQGANGLQFPSHPYTGYQAKADSLLEEYVSLGRLPASNATVATVIRAAWAFVASRYINSEDVVFGETLTGRNAAIVGAEEIEGPMITTVPVRVQVDREMPIVEYLQTIQEQTIEQIPHEHFGLQHIRRLSPDALEACELKTGLVLHPSTANDAAAGADLPADRLVPAGDSEAAQEALKFNTYSLMLVCSIDPDGFLVMASFDSKTIDSGTMQRALRQFKKVAQLLCQGTSGRVGDLEYLTPDDVDILKTMVASNTQDAQLHQYSGVQGAFIVESQDVNKLLPVGGIGEVIVSTSTVLELPSIPSPSWLREVSDSAPITAANFYKTGKLAKYTAGGLLQFIESSPNQNVNGTRAQAPVKRVSATSRRQRKLRSLWSRVLNIDEDDISLNDNFFLLGGDSIAAMKLVSEARAEGVKLTVVQMFQKRTLYDMASVMEEVAVDTSASEDVAAAFSLLGDANASEFVETVVRPRLENKASNVLNVVPTRPLQQIAVKGTTQLPRYSARYELMYFDDTIDKQQLRYACEELVSRNEILRTVFIEHNGKCYGAVLESLEAEFVVDGVGSSYSGSIEEYARNVCQSDVMSDMPLGSSFVKWFLVEFPNGKSCLVFRLSHAQYDEICLPILLRQLSALYENRPVQESVSFSSYVGHVLRRNIPESTQYWKDLLAGSAMSILKPDIPVQKSNHFAVQHTVDISSRPRDVTVATLPTAAWALCLSRRLSLRDVTFGEVVSGRNIDFPNADAVTGPCWQYVPVRVKFDPSWTVSDLLAYIQHQHVASSAHEGMGLSEIRDQCTDWPDATPDWFDSVVHQDVAHVERLPFAKVSSRMETVYPHEEPLREWKIQAFIDGDSMILEIVTVDSWAEYAKELLMDLADVARFLIREPREKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU74</accession>
    <name>A0A7D5UU74_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-arginine deiminase type-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Padi3_1</name>
        <name evidence="2" type="ORF">G6M90_00g047990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544915.1">
        <property type="nucleotide sequence ID" value="XM_014689429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU74"/>
    <dbReference type="GeneID" id="26242256"/>
    <dbReference type="KEGG" id="mbrn:26242256"/>
    <dbReference type="OrthoDB" id="5102063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004303">
        <property type="entry name" value="PAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013530">
        <property type="entry name" value="PAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036556">
        <property type="entry name" value="PAD_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837">
        <property type="entry name" value="PEPTIDYLARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837:SF8">
        <property type="entry name" value="PROTEIN-ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03068">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110083">
        <property type="entry name" value="Peptidylarginine deiminase Pad4, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-arginine deiminase C-terminal" evidence="1">
        <location>
            <begin position="187"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="618" mass="68406" checksum="317F742702968EB6" modified="2021-02-10" version="1">MYSLGKTAVLALAAAGTSHGLRATILADTNRDGRVDVTGKTDVEGKATWTEERGALFLPNIVDTNRRCSQRITSGTTENGLAECHDASDNILRNPKYLAPLRTVPINNLTSSATGTITISGKYAPEKVRVFHKDNGKWTYINSNYEFRGDALGTGLELGIDARDVRRPNEWDGRVHVHFNVTDNGETASDQVALRVAPILTHHHLQAPDQVFTVAGRGRPAQAQFAAFIANYTAQAGVTKPVYMFDESDVWAQDYFEPGYTSIPGPEGPVYLRVNIRSSQPWRTAGRRVFSELRSDSVGAVQHFAAGTPEAPPTIDSTGNLETIPPYSYNGKRYPAGRAVMGRHDNKTPTMMSFLKAQEAQHPIDDLDHDWLSVGHTDEYMQFLPANNSRGWIMTADDPAYGLSLLKKARADGHGKVQAMSRRHEPYDTEACLPANDIDGVLGLANFDSVNQHCADRIQHNIDIIKRETGITDEEIVRVPSLFYYNNIEGFDCNRYVARARGAGGRRTARAQTKDIIEAAEAGSHLHSRQEQQAKPRMLALYPATINGVVYDDRRYMAPNPWGPVIGGRDILAEAVRAAYDKAGFQLTFMDDWFDHHVLNGETHCGSNVARDASQKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUH4</accession>
    <name>A0A7D5UUH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">OXCT1_0</name>
        <name evidence="5" type="ORF">G6M90_00g042980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547632.1">
        <property type="nucleotide sequence ID" value="XM_014692146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUH4"/>
    <dbReference type="GeneID" id="26240195"/>
    <dbReference type="KEGG" id="mbrn:26240195"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="519" mass="55416" checksum="829949D96A426449" modified="2021-02-10" version="1">MPSAALRMATLRAFARHGCNPSPALTRSFSVSLRRAEINKVFPSASAALKDMKPNSTLLCGGFGLCGVPDTLIDEILQKPDITGLTAVSNNAGTDNSGLGKLLKTKQVKKMVASYIGENKTFETMYLTGEVELELTPQGTLAERCAAGGKGIPAFYTPAAFGTVVQTGDLPLKNKADGTPDEYSYPKDVKVFNGKSYLLEHAIDGDYAFVKAYKADKLGNCQFRLAAHNFNGAMGRNAKMTIVEAEHIVEPGEIPPEAVHLPGIYVKRVIQSTSEKNIEKFTFAKDESDADAKAALGTGDTAAKRERIVKRAAKEFKNGMYANLGIGMPMLAPGFVGPEVEVQLQSENGILGLGPYPKKGDEDADLINAGKETVTLNRGAAVFGSEESFGMIRSGRINLTILGAMQVSGTGDLANWMLPGKVKGFGGAMDLVSNPSKTKVVVTMEHTDKKGNPKIVKQCAFPLTGRACVSRIITELGVFDVDFAHGLNLVEIADGVTVDEIKSKTEAPFTVSKDLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUJ9</accession>
    <name>A0A7D5UUJ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g043790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986345.1">
        <property type="nucleotide sequence ID" value="XM_066130334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUJ9"/>
    <dbReference type="GeneID" id="26240277"/>
    <dbReference type="KEGG" id="mbrn:26240277"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="673" mass="70861" checksum="3FB937626A4A3AF5" modified="2021-02-10" version="1">MAPKKHFKVHSLNKHIEDTKKGLSAEAQYNKRPIPKSKVSIKKEPGAIDKAIFGNESEDDESGSSSSESSDEDGPDFLQKLQVSKTSNTATPKKPAKRDEIADSDDERRSTAKNVTSAKSKRPVQSGAPSSDDTSSESESESGSGAELKSVKGEQKVRANGGPLKTEAPSSSGSTSGSDEEEEEGDESSSDDEPDKKATATKVKGSTSSDQESSDSASDDESDDEGEPAASKKPKAAITSTNGTSTATTSETSSSDEGTDDEDQTAVQAKPVATRKSVPEEPSDDASEDSSEEDADVSMHIADRQHDPRATVPDFIAPDFILRKSDGGTNGQDVALVQNMEIPMNQSQSGDSVFSHDGEDYGISMDSMTPKSSIQILIPSSDGTRYQSASRPIDQVMQVKKITQLGQGSGATSSVGPTPKPPARQQPEGLKARYQPYGVTSPMGQIGVDASFHIEDDTEMADAPAPAPAPAILAGSAQNKSDKKEKKRKEKGESETPRKGKRKHVSSEDDAVAATEQLMGENLSAETKTKKQKTERVGSPDLGSDAPPSSAVSKKQTLLVPPAIPGSTPSSKSKRSKSKPETPASKPRETAVPVPQVPGSSQHKVSPVPIPQPGVASTPVADRDSKKSKKKKTKTPDATAKTQQSPPPSAQPAGRNSKIKLTPVPMPKLKTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV68</accession>
    <name>A0A7D5UV68_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-dependent monooxygenase aurC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aurC</name>
        <name evidence="9" type="ORF">G6M90_00g030170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539730.1">
        <property type="nucleotide sequence ID" value="XM_014684244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV68"/>
    <dbReference type="GeneID" id="26247487"/>
    <dbReference type="KEGG" id="mbrn:26247487"/>
    <dbReference type="OrthoDB" id="4940251at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="7"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="458" mass="51518" checksum="5FBF25E3114468F8" modified="2021-02-10" version="1">MEKSSFKVIIVGCSITGMTLGHCLDRAGIDYVILEKHENIFAEPGVSLGLMPNGSRILEQLGIYSGVDEIYEPIHKIYQFLPDGFGLPFCVIARQHFLQVLYAKFEDKSRIHMSKKVVEISHGKSNVSVTAADGTTYEGDLVVGADGIHSAVRSEMWRIGNSEQAGFITETEKSELSAEFACVFGVCKAVPGQGRWEHILRYNEGFCFMFFPATGTDVFFNVIYKLKQKYKYPNIPRFTQDDAFKVCESVGDFPVWKDIKFRDVWEQRTSFAIVALEEHMFTNWHHRRIVCVGDSISKMTPNMGQGANTAIETVAALTNELRTLVKANHPDKPSEYELNNMLQRFNRKQFRRLTAVHGDARYVTRLEALDGAMHWIFSRYIMGHCGDVLLGNTARIVSGGKVLDFIPLTARSGKDWPPCPWQHSFGISDMIDFCKKMSIAFLIALVAVVLSAFGAGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV94</accession>
    <name>A0A7D5UV94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">J domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">JID1_0</name>
        <name evidence="2" type="ORF">G6M90_00g044260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547760.1">
        <property type="nucleotide sequence ID" value="XM_014692274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV94"/>
    <dbReference type="GeneID" id="26240323"/>
    <dbReference type="KEGG" id="mbrn:26240323"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="212" mass="24540" checksum="E498E2F8501DEE94" modified="2021-02-10" version="1">MQRGAPYTKRRFYQLVKLYHPDTHDKDAPPSSSPQQIPHATRLERYHLVVAANNLLSDPNKRRLYDHHGIGWTADHRAPDLREVDKAWRHQPGNASRNATWEDWEQWRNERDGKPSEPMYMSNGTFAALVVCMCMIGALAQMNRAEAAGEQYVDFVQQKDWAIGQKMRQNNMASAGRTKDERVDTFLRDRENLSFDFQPAKYDDPSHANRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVR4</accession>
    <name>A0A7D5UVR4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Proteasome activator BLM10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">BLM10</name>
        <name evidence="14" type="ORF">G6M90_00g036000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546993.1">
        <property type="nucleotide sequence ID" value="XM_014691507.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239556"/>
    <dbReference type="KEGG" id="mbrn:26239556"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="385"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1370"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1868"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="912"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="931"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1955" mass="221742" checksum="D38B15AC2CEFF901" modified="2021-02-10" version="1">MDENIGLHHEGSLAALPASSAAHLLSNFHPYEPISRATSPGIPYPKADEDDKKRYRPRTFAYFQQLPFDVEEEQQRDAALQGILKQLYIAIKAEDFSPGALHWTRELQAWLALKFEMTRELRAKLARLYYSLALAPGLDSNTADRFLRMVLTLIRKNHYLKPGEDLTFDWRPIWHEVKGIVLPSEGPSLQSGRRRPAKQLLKLCTHAHTYFDPRDRPAMLEEFLPFFSINDMPNAFIVFGLINTFLPSHPAPEKDVAAQPQEFLPTIFHLWSIMSRSKVADICLIDLFSRLARDHVHCGHVPFGAHGIFTKAQSDLIFTSILRLTQIPVGQANSPYTALDYLAGAGAYLEKDSKKHPVPYMMARLIVSSLSPRCMDQDDSIMASLEGLMESIDTFFHPSNQGSWTNMLGQLTLYLTDAFVSRWNREQSGELELPKERRISPALKKRFVGSLKEVTFMGLFSKSNRVSNCYYNALQGLAYLEPDLVLPGALQRFYPSLQGLVEVHRTTSSLNSLQMIANVMSKLKGYRCHITALLALALPGIDANDLNKTQYTLNFIQSVAYSIPFVELTKEETHIHDTTLAMQWVQAEMDRMERDGQNVQIDYEKELSDEDEANILRSSTAGFGEFILTLLGKVFTLLENLPDANQVRGGTPEDNVVNALPAALSPLFASLSPELFDMALEKIATFVSSHVVHQARDAMAWILNALCKVNPEKTLKVFVPMFVINIRNEIDQNHAASDRTTGTDYLPRDRALVWHISMLAMTVVHVGREVLNYKDELLGIAVYMQEKCRGLPTILVSNYIHHLLLNLTNTYPIDHALHEPDVIKRGLDIDDWGKTTSPADLTIRWHQPSPPEVEFAVELFASQTKSATEQLELLFSDNPPVSRTGKNKEWSDEVSRLMQQMRLVISGMSTMFDPKRASGNGNEKLSNGNDGDGDVEMGEDDESLAEGAEDEELRPQFRYKAGYLLKSDDPVYGRIHELREQLGHLLSKAHSFLSENQEDDVICSTALCNAYRTWITDVGIERSAHPLERHLRLYKADIAAFKIKGLRKVYPRPLLIKRAEAYQLLRMKHNASARHKSELDRRLLLDLAKSCQSLYADVRRAAQTAQDSSLKVLIGGKPLVVPVVLEGLRKAIEANDHDRIKGGMYTLFFTSLLRTIVRDWRFAPDAMSLYIETAGIDKPSIQNLGSSALYSLIEFGKANEGLILLDDAILNAIRPSGDTDDAVDNRHRVILERRKKIETAKAALGLQLTNRAKGAHWKIATRCAIFALNLCLRFDDLAPAEFVELVANGTIDPHPGLRGYYLNAFTSLLGAIDMRAVYGHDYANYLMEKEIGDRNRIDVPVEKGDAEFTRNFLEAFNKPEEAEYMVDSDHPGWLVWGSKFTAFRARPLPFDSYDELERNVRRQIGNILTKEWMSQCFEYLKQEPRDQSTDRFRMSNVYLLMHVFDLTYYGSTTVTLDEIKELAEGVFGDGSDKHQHRATAEIIGALLAGSSDDPVEMRNKVWEFAAPMLLKILNDGLTPENLQYWLPCIHLILDSRDPRRSREILDSLKTFRLDITSNAAFKDSSKVQLLEFVLADGGWHFRQEKPILDDFLAHIDHPYKAVREAMGKVLCVIFRTRYHESFESVPKLIEANKKASSIGIRPYQPSEELTSAIKDVFDRLEKWRHEREPGQQTQSSYTSGSKTVLTWLDCTLSSNECTMLVPFFATPFMEQLLHMMDVKEDPELMRIAYHVYRHLPNIPFREGEDAKFINALIKIGRSATSWHQRLRALVNMQVVYFRRIFLTAASERDALFTAVSDMLSDPQLEVRGCASTTLAGMIRCSPRHIRDPMIARLERRFKDELQQNPMPKRKTHLPGTETPVDIHRQINRRHAAVLGLGALIEAFPYATPPPEWMPEVLATLARKAAGDPGVVGKATKGILSEFKKTRQDSWSVDQKYFTPEQLEDLEGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW70</accession>
    <name>A0A7D5UW70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RNF150</name>
        <name evidence="15" type="ORF">G6M90_00g034320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986351.1">
        <property type="nucleotide sequence ID" value="XM_066130148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW70"/>
    <dbReference type="GeneID" id="26239393"/>
    <dbReference type="KEGG" id="mbrn:26239393"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="178" mass="18657" checksum="400915B94A42E528" modified="2021-02-10" version="1">MTAASRNPPPVEGARPPLAEGSSSHDDTAAREQNTTQDAPGCSICGEPWTRAPSPPRRLPCGHEFHGACIDPWLLGHSRTCPLCRGRVAPLSCCPSALPAPSPSPSVVVAPSRWNVLRRGGPRDVLALTSIPSIRSQGSGATWAERITVLPLPLPLPLPLRSLNETADVDAAPRPGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWG6</accession>
    <name>A0A7D5UWG6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">dad3</name>
        <name evidence="18" type="ORF">G6M90_00g035000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546895.1">
        <property type="nucleotide sequence ID" value="XM_014691409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWG6"/>
    <dbReference type="GeneID" id="26239458"/>
    <dbReference type="KEGG" id="mbrn:26239458"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI68518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9637" checksum="05F2B278CE1DDBA0" modified="2021-02-10" version="1">MEQNILSTPELSPLEQEVLEEYERLAGNMKQLASVLDDLASNPSTEILDGLRDLERKTSLAFTLLKASVYSIVLQQEIDWGGGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWL6</accession>
    <name>A0A7D5UWL6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plcA_0</name>
        <name evidence="3" type="ORF">G6M90_00g046950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544818.1">
        <property type="nucleotide sequence ID" value="XM_014689332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWL6"/>
    <dbReference type="GeneID" id="26242159"/>
    <dbReference type="KEGG" id="mbrn:26242159"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028821857" evidence="1">
        <location>
            <begin position="23"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="50"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="330" mass="38537" checksum="7EE4B697B6C4FA5E" modified="2021-02-10" version="1">MLLLLYMMLGLGSYLSPHRVNGQSYKEFRSRCSFDADISYWPDWVSSLPDVMNISSLSIPGTHDTMTYTISNSTLQCQNWDLKTQIYAGIRYIDIRARVKDNILTTFHGDEPTGVTFERILLTIYDWLDTYPREWIIMRLKEEGAPLGNNNMTFQEVFEDTFNNYYFIKERAKKHWFAYNTSMPIPSVAQLRGKILFLQEFPSTPPWKYGIEWNGPQMILQDEWIVKDVNHLDDKWKAIEEHFEITNFRPNDNSYLYVSHLSASVGVLPVEAAAGPLERSIVGMNDRSCDYIEWHYPEPDALRLGTVISDFPGKVLIFDIIRYSRRSYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWV1</accession>
    <name>A0A7D5UWV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavine halogenase aclH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aclH</name>
        <name evidence="4" type="ORF">G6M90_00g063650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986722.1">
        <property type="nucleotide sequence ID" value="XM_066130763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWV1"/>
    <dbReference type="GeneID" id="26244469"/>
    <dbReference type="KEGG" id="mbrn:26244469"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="578" mass="64222" checksum="CFBCD77842E643D0" modified="2021-02-10" version="1">MAVPPSCTVLVIGGGTAGSYAAAALAREGIETVVLEADKFPRYHIGESTLPSLRHFFKFIDFYDTVDAYGFYHKNGAVFRLAQAQPDACKSPSPAYTDFLEAGGPDGYAWNLIRSEFDDLLFKHAGTCGAQIFSETRVDTIQFEPVANGLKPDNRNLEDHLNPGRPVSATWVREDGTSGSITYKYLVDASGRQGILSTKYLKNRKFNNNFKNAAIWAYWKSDNVYGPGTHMEGSPYFEALDDASGWAWFMPLHDGTRSVGIVQDQKMVTEKKHELGRPSTLDFYKQCLDMAPRIRELLSEAELIPHVRAACDWSYTASTYHLPNARICGDAGSFIDPLFSSGVHLAITGGLSAAATISASIRGDCSEAAAGSWHSKKTVESYTRFFLAVSSATKQIRTQYEPIIKDMDEKGFQRAFDLFRPIIQGTADADEAGKVSQLEISKILQFCFKAFTYVPPERKDALFDKLRKLDSKALQDDAKQVQTLNGIEKYLTADELQILEILRSRRMIREDPFEMDSFSLDTIDGMAPKLVRGSLGLVNYEQVKIDKAHFYSQDFLDGNCPGIREGSVHLPTSRVQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWX4</accession>
    <name>A0A7D5UWX4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g066070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986658.1">
        <property type="nucleotide sequence ID" value="XM_066130815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWX4"/>
    <dbReference type="GeneID" id="26246974"/>
    <dbReference type="KEGG" id="mbrn:26246974"/>
    <dbReference type="OrthoDB" id="4917004at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.40">
        <property type="entry name" value="Diphtheria toxin, translocation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028848609" evidence="2">
        <location>
            <begin position="17"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="970" mass="105220" checksum="2BB6D194F2DE431E" modified="2021-02-10" version="1">MFAFVAISILLIGIYGQSNNPNSEQQDALFQQYETQVAQVLEQASHGVKCYTDYVPRVEHESPTLPEVFSLDKCHEAHDAHTIYLRDARNTARQHNFTRDQLLDKKLPYVFNTQQGGQDEYTEAYQIKLQQLRDAANSAQKVYRAKRDVVMEATTEAASKLKEESSEHAKEIAGAGIAVGGVAVTGGVITFGPFLAKATEVADHVEKIEASATTAHSALTPVLNNPVSQITIGDLAQMRFFASAVVVGACYSKLDQITPLSISMSDHGTKQFLFYIDSQSPDITFNDGLKPNRGRHLLDDFETGVNEQPQYIYVLSLEGSNHTASYGAKTHTGSTETFVPAINGSVKPETIVGAYPFGNLHGGRHVIREWIANPKYEHINTSPYIAQGNSCLARACPGARHLASKTCHSIVSCLSIGGKKLQARGNSQGLQCHLGAVNNLCALGEALDPVVETPSTLKETSIGEVADIAEKVSQDEFAKLVKKFKLTRVVERWLMSIPDARKRLLNYKPLGPKSPKLRAGSGGTAGSLAIGAIGAIGAAAWVGGVVAAFVRDASALDRAAAVTSIIPLAGCITGLAAEENRGEISASSGVDSTMCFLGDALILGGLAPIGVVVHLARLLVQTFTPPPKPPTKEEMQSLRDTQWQGFTKNSLYTYIYSHAYLYPSGSFANKLENALAIEAMMVISEGAQSIGALNASSRVPDSNSDQELLQGNSQEAAEKIREAISVEITGRQQRFLLGLPAVLRSNSTALLKTTAEQFNDNFVKKVTSRETVDRYRSFQENPSPGGRLPGRSRQQFLVKLMDGIGKHLRETPLPMPDLIEVAFILGQSKGLTNIDPLVLSPREYMKQLANTASEEDINRVTIQHAFGVLHLIQGKIKQHELPTIFPVQDSQSRQGLQVLLAMQIGKAYEEAKIKRADKFKGEYLPDSDRKVLIHPLTIPLEEHPDAPLLIGLVLGISKDLVEASLAESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXK9</accession>
    <name>A0A7D5UXK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atp7</name>
        <name evidence="14" type="ORF">G6M90_00g060410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544611.1">
        <property type="nucleotide sequence ID" value="XM_014689125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXK9"/>
    <dbReference type="GeneID" id="26243023"/>
    <dbReference type="KEGG" id="mbrn:26243023"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI69298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="174" mass="19438" checksum="E32B9CA98212EDFC" modified="2021-02-10" version="1">MAATRSAALKIDWVKVTSSLGLRGQTVASLQAFKKRNEDARRKVQQLSEQPTTVDFAAYRSTLKNQAVIDEIEKRFNAFKPTTYDVSRQLKAIDAFEVEAVKNAEATKQAVDLELKDLAATLKNIEEARPFEDLTVDEVAAAEKSIDEKTTQLISKGRWMVPGYKEKFGDLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY86</accession>
    <name>A0A7D5UY86_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DOA4</name>
        <name evidence="5" type="ORF">G6M90_00g038030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547162.1">
        <property type="nucleotide sequence ID" value="XM_014691676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY86"/>
    <dbReference type="GeneID" id="26239725"/>
    <dbReference type="KEGG" id="mbrn:26239725"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="382"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="650"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114406" checksum="8925F792B6530E0A" modified="2021-02-10" version="1">MAANANPRHSMPVGGYHARNGASSGPPRSSAAPFPHIDDLVSMPKDINPNQSIRKLLEQAESSFRQSELHRDFNRPAIALKDYVRAFVIAVEVIRRHPDFPTMASKQGDASLLHKALLSKINRQSEIYNQIKQDIMADNRRTGVRPTVETSPVVTTVNGLSNAPLPVTSNNGVRPVQQEERQQQKKLPNGHVPHLPNGGPPAKSKPAVNPKPAALHGNAIPRHNRTNSANNMTLDLAARFANLRGPQPSPGQDPRIKTYPIIPQRPAGPRQMPPSPPKVNTNMSYDTALPKPPDAIYSPVRGSVSGEAARLPTSTPRGLFSRKGSSTSISGTPSANQPRQSDEYFPLVPPSAPKPSDVAEKALKIPEGNTITPRELITVREAKPSILYIDVRPREDFDEGHIMAVSIICIDPNILERGDVTCSDISEALVLSPPTELSLFEKRQTYDLVVFYDQDSESFPKSDKDPRDIALWSLNRALVELSYDKELRNPPKLLKGGINAWTDLYGAGSLRSTPTTDAKTQPRASKRHPFIQRRGSKYVFNPLPEKDVETFRKGLEKDAAPPSFPRTRDEFLRFPPVSLEQQSMSSGISAEQRYKHDFATGFGSPVQMLTPPTRPQAAVQRPSHISLSEDGHDDHEITEQVPATPVKVHTGLNNPGNWCYANSIIQSLLASPSFGREIADSEWARRYKNQVPRKPGEKMDQPQLMIQMLSNIFYWMSSGKFQTMKAQMLMDYSRHLCATGDPKTKFGGKDQQDAQEFMSFLMDQLHDETNLRRGQQGTVDQPNVQGIQLVQAAERYWENHKRLNDSIVDQYWRGLQLSTVQCHHCATRTYTFSQFESLGVNVSGDRNMTLSEALRQANTGDEIDDFRCNCCATSRPAKISESLARMPPLLCVSFRRFQVNGRGVVKSTAEVTWDFNDFDFTPYFLNSAEDWQGASTHDRAFCGPFRYQCYAVIVHSGRSIDSGHYYAYVRDSSTHDPYAWYCCNDSVVTKVRIGSREPTDIQNTVFKSGSDAVPYLAFFRRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYB9</accession>
    <name>A0A7D5UYB9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540483.1">
        <property type="nucleotide sequence ID" value="XM_014684997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYB9"/>
    <dbReference type="GeneID" id="26246845"/>
    <dbReference type="KEGG" id="mbrn:26246845"/>
    <dbReference type="OrthoDB" id="4939624at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="218" mass="23214" checksum="CEBE02106EB547B5" modified="2021-02-10" version="1">MSASRPSRPAPSWNGEVDKVKEARSRGDAAAAITTANAAADNIESHIGETMTGSADENEALTAAQRFTFNVAADAWPGWQRDGPLPDKPTLLRAKRLAQRSASLVDRLKLGPVQVGTGAWLVGAFDLVLGDFEEAIARFSAASDNYHAASAPGLELLTSGYAVMARGLGESKSEDDIAGDLDRVIAQILAGSFEDGEEWAEQLRTALAVVSRKEYREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYU3</accession>
    <name>A0A7D5UYU3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase helB3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">helB3</name>
        <name evidence="7" type="ORF">G6M90_00g052800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540406.1">
        <property type="nucleotide sequence ID" value="XM_014684920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYU3"/>
    <dbReference type="GeneID" id="26246768"/>
    <dbReference type="KEGG" id="mbrn:26246768"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="543" mass="61992" checksum="6DC3853BF804C0DE" modified="2021-02-10" version="1">MTSLSTQGVYFRLYHILEEKTRHRPSWIEQANYTAWLLCLVVAYATWKIAYARLLSPLRHIPGPMASRLTSKRGTWAVITGKASDIALADYNAYGDVYVAKPNAVFLCDPEDARNVLSVGEFRKTDMYRIFEYEGVPNVSTFTDPVEANRRRRQLHPFFNYGYLAKVEHKILEKGFLALRERWNKAIDKAAAEAGHADTTVVNYRIDTQLAMFDITGVLVFGRDFHALRDTNLDYTSWVNNTLTYMLLNHYFPVLKRWPFSGLTRRLKKSYDDLARFSRDSITIRKQLLDRGDKKPVDLLQALLDSVEPDSKIRMTSREVQTESISMLVGGSESTSSVISWVIHFLLLYPNYFTRVVNEVRSEFPPDHVITQAESRAKLPFLEACIYETLRCIPTASTSFPRISHQRGITVKGHYIPPGTEIVTNKCAAHVHRETWEDPFDFKPDRFIGGNNDSAEAKRNMLSFAYGTRVCIGKNLAWVVMMVTLANLFNTYDISIPDDSIFRPENVDADGRPKIMPTKLGVATMPANPDRDCRMVIKKRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ66</accession>
    <name>A0A7D5UZ66_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545316.1">
        <property type="nucleotide sequence ID" value="XM_014689830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ66"/>
    <dbReference type="GeneID" id="26241349"/>
    <dbReference type="KEGG" id="mbrn:26241349"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23551" checksum="1443F17680AA69FA" modified="2021-02-10" version="1">MSVSPMLNGLHPSFQSPSSTGSFPSPNHHQLSPSSAVTALYYSSPNLDIDRDTPSPRPSPEDRGSKPSSQSGRDYPVCCLYPGCNAKPFKRRADLDRHYKHRHASESQKVSFNCDYPRCSRRRDPFHRLDHFRDHLREFHKEDIEKRGGSINEEWLEDRRVSSTWWRCSKCLKRIYIDQDGYECPHCKTTCQPKRKEARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0C7</accession>
    <name>A0A7D5V0C7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SET2</name>
        <name evidence="21" type="ORF">G6M90_00g087200</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542398.1">
        <property type="nucleotide sequence ID" value="XM_014686912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0C7"/>
    <dbReference type="GeneID" id="26244912"/>
    <dbReference type="KEGG" id="mbrn:26244912"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.100:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 21" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="116"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="172"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
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            <dbReference type="Proteomes" id="UP000510686"/>
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    <sequence length="894" mass="100372" checksum="38511850BC859570" modified="2021-02-10" version="1">MEDDEHAARSMSRIKLEDGIANGQPEAMDTAESTPTHGIKGGASPASINGIKSESDGVNTPASGKPRLSRRSSQKPAEPEPRLFNHLPNVTEESCKSFQVIRDCLYGSKHLGSTDNDALDCDCAEEFQDGENFACGEDSDCINRATKMECVASGSNCGGGCQNQRFQRKLWADVAVIKTDKKGYGLRTESPLQPNDFIYEYIGEVINEPTFRRRMLQYDEEGIKHFYFMSLSKSEFVDATRKGNLGRFCNHSCNPNCYVDKWVVGDKLRMGIFALRKIQAGEELVFNYNVDRYGAEPQPCYCGESNCVGFIGGKTQTERATKLPTTVVDALGIHDADGWDTAVAKKPRRKRPEEDDEEYVNSLPARSLDEDGSRKVMAALVQCKEKWIAVKLLERIQRSDDDRVIHSVMRMHAYQILKTTLNTFIDDHNVVLQVLDILDKFPRMTRNKIQDSNIEATIQHLTNSEHEDVSAKSKKLLDDWSKLEVAYRIRRRKVDPNAPVQNLFDDRRGQAREEETAQSTPKTASPRPIDAPKGPKSSIPQRSVSFQHNNVNRPPRRFGPLPEGWFTAKDGKGHTYYYNKLGKTTWSRPTQPANDGPKAPSKAIQEQLAIQSIIDRVTKEGTPKQTLPQPTPSHVSDSSSKESRRSKWKALPIEKQMKIYENTVFPPVKHMLDKFRHRLPKEELKRLGKDIAKKLVASDYKNNRVEDPTAALSEKQTLKIKKHVKDFLTRAVEKYEVHQQKQAPKDTKSGNADGKTATASDASQSVGAEMADDMALSDMEENDSPSSQERKRKREADAADSAVATPSEGPETKRPRAEDGTEPSPPPPPPPPPDSSSDDTLTEEQNAEQRAFKEQEEALMRENEEAQRLEDEANKTKDMEEKAEEIRKDIVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Q3</accession>
    <name>A0A7D5V0Q3_9HYPO</name>
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        <submittedName>
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        <name type="scientific">Metarhizium brunneum</name>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11 12">4556</strain>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="104"/>
        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="191" mass="21980" checksum="AB45533B317569A8" modified="2021-02-10" version="1">MPPRAHSKTSRVPRRPFESARLDSELKLVGEYGLRNKREVWRVGLTLSKIRRAARQLLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKLEDFLERRLQTCVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFIVRLDSQKHIDFALNSPFGSGRPGRVRRKKAKAAEGGADGEEEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Z9</accession>
    <name>A0A7D5V0Z9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chanoclavine-I aldehyde reductase fgaOx3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fgaOx3_2</name>
        <name evidence="3" type="ORF">G6M90_00g078920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545218.2">
        <property type="nucleotide sequence ID" value="XM_014689732.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Z9"/>
    <dbReference type="GeneID" id="26241251"/>
    <dbReference type="KEGG" id="mbrn:26241251"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38443" checksum="83CAD5C05AC05847" modified="2021-02-10" version="1">MSPMTRLRSDDGHVPLPMVTDYYSQRTAVPGSLAITEGTYISAKAGGYDSAPGIYSREQIAAWKKVTDAVHANKSYIFLQLWAQGRTAEVDVLKREGPFDLTSSSDIPMGEDAASPRPLTEEEIYSFIEDHAQAARNAIEAGFDGVEIHGANGYLIDQFTQDTANKRTDQWGGSIENRARFALEVTKAVVAAVGADRTGIRLSPWSSFQGMRMDDPIPQFTYLAGKLKDFGLAYVHLIESRSGADAAAKATDSLDFFFNEYNKASPILVAGGYDATLAKEAVDSKYHDYDTIVVFGRPYISTPDLPFRVKEGLAFNKYDRSTFYLARSDKGYIDYSFSDQFNQVRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V266</accession>
    <name>A0A7D5V266_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endoplasmic reticulum membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g099200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987572.1">
        <property type="nucleotide sequence ID" value="XM_066131557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V266"/>
    <dbReference type="GeneID" id="26240849"/>
    <dbReference type="KEGG" id="mbrn:26240849"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="21986" checksum="9407FAB10CB541D4" modified="2021-02-10" version="1">MSLDLEHHLTFVSITTYGTSDYGAYHHNSINKLIHIICVPIILISAFCMATYSGTLIQTPSWLSVPYLDLNLGTIAALMYSALYLLLEPVAGFVLAAFCLAGTAYSNFLKAENPATTFQIALGCHLAAWIFQFVGHGAFEGRAPALLDNLLQAIFLAPLFVWLEVLFKLGYRPELQARVDKKVQQEVAKFKAASKNGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2C1</accession>
    <name>A0A7D5V2C1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g102320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546114.1">
        <property type="nucleotide sequence ID" value="XM_014690628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2C1"/>
    <dbReference type="GeneID" id="26240537"/>
    <dbReference type="KEGG" id="mbrn:26240537"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="173"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="309" mass="33936" checksum="37577AC3147B3DFD" modified="2021-02-10" version="1">MSGPGVGFEYPPQEVTWLKRDVLLFANSIGATADELHFLYELHPKFAVFPTYPIILTFKGNTQEVIDFYASSKAVKIPSVPEFDYRRVVDGQRKMEFLKALPTSSEGRKFESRTKVLGVYDKGRPGTVLDVQTDLVDTATGEVYTRVTTSSFFVGQGGWHGPKGPATKNFPPPKDKKPDAVLEHQTTTESALLYRLNGDYNPLHATPEPGQKMGFGGAIMHGLYSWNTTCYLILKTFGGSDPANVKEYQARFASPVKPGDKLVTSVWRTGEKQGDFEEIRFVTEVAGGKVCLSNGRALVKVVGGAASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2H0</accession>
    <name>A0A7D5V2H0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase tropE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tropE_2</name>
        <name evidence="2" type="ORF">G6M90_00g081210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543361.1">
        <property type="nucleotide sequence ID" value="XM_014687875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2H0"/>
    <dbReference type="GeneID" id="26243538"/>
    <dbReference type="KEGG" id="mbrn:26243538"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF36">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE (CSGA), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="254" mass="27199" checksum="6C5057CDEF2FCEF5" modified="2021-02-10" version="1">MSTVLVTGGGRGIGLELVRQLVQLPESRISLVLVTTRGPSQPLDELISSSAGRIAQVQCEITDDNSVKQAAAVIETKLAGKGLDILINNVGIMSYTEGRVGALDGQQLLTAFNVNVLSTHRITAALIPLLQKGTGKKIAMISTPLGSIDYANRYTWLPVPSYKITKAAMNMLSVQYAIDYEKEGFTVVAVSPGWLRTDMGSQDADLDVATGVRALKDLILSATVDANGKFYNIHVPGWENAEGPNQYDGAVIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2K9</accession>
    <name>A0A7D5V2K9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g104250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541421.1">
        <property type="nucleotide sequence ID" value="XM_014685935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2K9"/>
    <dbReference type="GeneID" id="26245671"/>
    <dbReference type="KEGG" id="mbrn:26245671"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="664" mass="73657" checksum="59654919BE065759" modified="2021-02-10" version="1">MDFLAASIAYRTAVTKCHPGDCKIQDKILYCSAILKQAAAGDSDIQDARMRFQAWHTNYTAGRAATPSLDEHLRDAPDVRAATLESLEDLVSAFKCGANSSVDRALMQKAVESLEHISIFLEMPASVDWYKKARYVNVDHFIPIDKSHIDELFPKADPVLRDRLLQGVLSRRRALRYAREHKEELAKEAPCPQDEEGDENESSDCDDDETARHVSSDVLPYVCTFIDCEELGRLFESRGEWYFHELSHHRRTWFCIRDCLEKFDSKSAFEAHLSVAHGELGGVTRAEELGAHSTRLPEPETSMCPMCGDEIRDPELVMEHIGRHQAQLGLWTLRSMGYFDDEDDQEGYEEDEEDDAEMSDDDDKVPDNPAPSQDAAGSDSPPPGSTETWPSFDRESYKVGWVCASPDDLAAAVACLDARHKAVQPIPRDGSYYEFGEINGHRIVIWCYGADGNRQASVAWPAAEMPYKFPGVKVYVSVGIGARVPSRHANIRLGDVAVGSSGTMHFGMGQDGLLELQSRSNLPPRLLRSTLQKLLADSETGRFQLQGDIQSILDKNPRLRDDYSRPDSSSDNGGRPAVGRSGLIVSSTTMLTNDNCPKAVANTEEIVCFESEGTEISALDCLLIRGICEYGDSHKDKQSQRYAAMSAAVYARALLGCTPPTMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2S1</accession>
    <name>A0A7D5V2S1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g097710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546571.1">
        <property type="nucleotide sequence ID" value="XM_014691085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2S1"/>
    <dbReference type="GeneID" id="26240994"/>
    <dbReference type="KEGG" id="mbrn:26240994"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="38538" checksum="1299440BBBB9F9DB" modified="2021-02-10" version="1">MAPVRNKKRVSDQSTASRRHGAATDTKVPIKSPSTPHDKSPIKKRRMGISALQKQALIDNLQLEVTERARRLRAQYQLQAQGLRSRIEIRINRIPMSLRKLTMGDLLLKCSQQGQGRVVSRPPVPAKDTPRSSPQRTLPARNQAVGRGYKRMSNEVAGDKENDFEIGDGAKKRARAETGRVRPNQILSPTSSNSRLANRDRPVSPAKPQIPRPGSPLKSTAASRAAATSVLSSMVEKAKATRTRGTRKVTTTSEASSASTTATKTRRPATATASRAPVSRPVTRTGRRPSETSDTSEASAGTVVRKPATSKKAAPAVTRTTVMGTIRKGVTGATAKRAAAKAAAPSATTAASGRVLRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2T7</accession>
    <name>A0A7D5V2T7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell cycle checkpoint protein RAD17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Rad17</name>
        <name evidence="10" type="ORF">G6M90_00g100490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546300.1">
        <property type="nucleotide sequence ID" value="XM_014690814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2T7"/>
    <dbReference type="GeneID" id="26240723"/>
    <dbReference type="KEGG" id="mbrn:26240723"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="507"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="811"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="860" mass="93614" checksum="6F57EDCF5CCDA269" modified="2021-02-10" version="1">MAPPAKRRRRNPVEASDDEDEQPRANTLSNFLLSSPSSSSKDPAPTASTSSPKGKGFAGQSGTSFSPRKTRQASLQKNGSSLSPKKSKNVGRIEERGKTADLKALFLKQAQRATKPGNGSEKRPSPIDDPISDPISEDDEISELKASSSSLVSQHARKRLKNGSATAASESSNTGSMFLKPPRPANPVGVDDDLRPWSERFGPRNLDELAVHKKKVADVRKWLEDVMSGRMRQRILILKGAAGSGKTTTVRLLATDMGCELLEWKNPTTNSGTGYVSVSGQFGDFLGRSGKFGTLDVEEPVNTTMKNSNGLAQSRAKRIILVEEFPNTFSRSSSALTSFRSTILQYLAAHTPSLASFGKAPQHRNQISPIVLVISETLLTTTSATADSLTAHRLLGPEILRHPGVGVIEFNAIAPSILAKALELVVLKEARKSGRKRTPGPQVLKRLGEIGDIRNAVSSLEFLCLKGDQDSDWGAKVAFTKIKKSTRDSISLTKGEAESLELISQREASLGIFHAVGKIVYNKRDEKAPANDAVENLPPFLSEHARPKRSQVSVDSLIDEIGTDTHTFISALHENYILSCESTDPMDLSTPVDYVNECIECLSESDLLCPSRDVFFGGRGGFGGFSGRETGSHLLRQDEMTFQVAVRGMLFSLPSPVKRKTTTMAKGSDAFKMFYPTSLKLWKAKEEIEGIIDMWSSRILKGESELATKNLTDGANAFLRSQSSGEPSSWMQRQQARAATANTTEQKEESSAPSPLLSLGSSAQREMLLDRLPYMAHMARTRRTGLRLRDLEKVVSFHGVTAAADEEFEAEDDATLGEAWATDKPSEESSPRKKTARIKAGGMSGMLDQKLVLSDDDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2V0</accession>
    <name>A0A7D5V2V0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reducing polyketide synthase DEP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DEP5_1</name>
        <name evidence="3" type="ORF">G6M90_00g093590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987646.1">
        <property type="nucleotide sequence ID" value="XM_066131453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2V0"/>
    <dbReference type="GeneID" id="26246340"/>
    <dbReference type="KEGG" id="mbrn:26246340"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="403"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="557" mass="58869" checksum="98E04113930DF58F" modified="2021-02-10" version="1">MEDMTCGSVPVQVDEVSLWPPTKAQLQNPKANAYSWTEERGVRLTINETQLVGSDGRLLLSLEVTSASPVKSVGLADLVALAPWKSPGVRVLEFGALNSTAICQATELINYTATATSKPGLEALEDTIAGFDHATAINVDPSLELEAQGLKAGQFDLIIPGTLTGSSKLASLLAPGGRIVPDQYTLSSLGKDFSILNLSNGFAIATAVAEQKTSGINGVRTRSIAIIYRNKPTEIPCKLVKACNALGSSRLARLADASIATSEHVVVTCDLEGPLLLELEPNELAGLQNIVSNTSSVTWVTSGGLMKGATPEQAMASDVPRSVTSEMASLDFTTLDLDLGNPTTYCAINEIDKESEYCLADGLVYISRLVPDATLDQEYGPQNSIPKATPFKPSDELVATAKAVKVTFSHDEHDHRTVGANQIQVQVMLSGVNKEDVLVMEGADSLTTFSHEIYGAVVQKGVNVEDINVGDRVFGFSADRLATFQTVSASVVQKVEQGDVLEELVTLPLAYATAIHGLTTLARVEAGEIVLILHGTGDGGAATITTSKKTKAQTCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2W8</accession>
    <name>A0A7D5V2W8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Citrinin biosynthesis transcriptional activator ctnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ctnR_1</name>
        <name evidence="9" type="ORF">G6M90_00g081130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543354.2">
        <property type="nucleotide sequence ID" value="XM_014687868.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2W8"/>
    <dbReference type="GeneID" id="26243531"/>
    <dbReference type="KEGG" id="mbrn:26243531"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="262"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="572" mass="64607" checksum="363D541A785B70A7" modified="2021-02-10" version="1">MACANSGVKCVVRDSFPPRGPKKGYLKTLQKRIEDLQTQLEKQQAASPTTAETPAFSPSQEAGNADNEIASSGSVESSTDHTEILHTACTTPGTAAAIPQWPASMEFQFPMVHMETWECFDNSSACSPFSSLPSLENIQDLVHIPMEPDLLITPMMHNDLDQLYFDRAYAFAPILQKHRYRSWSKQPNKNKKKTCLQHAMWTLASSLSSQFQVDGRKLYEKTRQALHSLESDEPCHQISLEQAQAWTLLAIYELTCQDFHRGMMSAGRAFRLIQMMRLYELDGPPHTMRLEQYQGQLSLQGPVQDDWIDVETKRRTFWLAYTIDRFTSMVDGLHMFFDEQLIRTRLPAPEANFASGRPIDMGFLADTIPVVDLEWPHNTLSPFTESVIGATICGRVLEHKQKPPTGPCQDFCRRHRYLNALLAQRIRMLRIHASLEYPDPIIAFVTLAAHTAVLMLYDIIESRPLGADAQGTQLTQALYAEHKQQSLDAVAYIDLLIAELGQHFQMHPLTPILLLLSARFSQSHPGLNDAYIRLMPRIVTMLRASTGLSKLAQNFIQILEPQYATGLPSPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V366</accession>
    <name>A0A7D5V366_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein IBD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541811.1">
        <property type="nucleotide sequence ID" value="XM_014686325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V366"/>
    <dbReference type="GeneID" id="26245279"/>
    <dbReference type="KEGG" id="mbrn:26245279"/>
    <dbReference type="OrthoDB" id="4174342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58366" checksum="C0905082BF76428B" modified="2021-02-10" version="1">MSPDTVSSLFPDRPIRPLPKRRLRERLPPEAADSIKCPVSTRENAPFFHYPPYTVKEAKEGSSQLTSVLADPTQPGRLDDSNRAVTPQRYGVQSDAGEEVHIGARSTVAARTPPEILNLSGRQAARQEQPRQVEPQPPPSATPSLDGYDSFENTNNKKKRKIPSAGESSINGIHGHGNEMNGLGLSAATSPPVDDDHGTERSYAGSNTYQASTSYAAGNQGFSGPGRGRLGRSGNARTPLRTLPDGNTTWTSRGVKAGATHWPAGSDSVGIISSAIANAGKLPPQGQENVSLLQQHSSASKSTPASAQFTFTCDSQVPGTVQWPGNHSRDDMATHGPDIHSNTNMNNSTSNDISQAATSSQSLRRTRRQLDRELKMAARRRRQIAEENLHENPPKPEDVWICEFCEYERIFGEPPKVLIRAFEIKDRRHRRKEADRKRLMEKAKAKSRKSKKPSKALNKGNSSEHHHPDHMPSDYIDDHQAPSMDHEQSHSTQSEEEYDDGVVDDQVYPQPYPLHQEGDGGGTQEQERAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3J0</accession>
    <name>A0A7D5V3J0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">G6M90_00g096760</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987722.1">
        <property type="nucleotide sequence ID" value="XM_066131516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3J0"/>
    <dbReference type="GeneID" id="26241083"/>
    <dbReference type="KEGG" id="mbrn:26241083"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="345"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="443"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="541"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="705" mass="78097" checksum="0A2FD0FDC5667165" modified="2021-02-10" version="1">MSSPSTLVKEAVKETLKGSGAPEDPSHQLSAQSKARFNAHAAKDPETGELYMGPEEFTNAIAPVTEDYHKIKRDQYSILFRVADNKDRGRLSLADWGVFENLLMKPDAEYEIAFRLFDVDRTGDVKYDDFRRLYELNKGPDNIPFDWDCEWAKLYIGSKKKRHNLSYPQFSQMLRGLQGERIRQAFQLLDRDGDGYIEPEEFARIILETSKHKLSDHLLANLHTLCNITTGSKISYANVRAFQNMIKEMDLVELIVRRAISRSSDGKITRAEFVNAASKVTRFSLFTPMEADILFHFASLDEPSGRLGLRDFAKVLDPSWRSPMYDVDESAVPVTKKASIFHGILESSYNFALGSVAGAFGAFMVYPIDLVKTRLQNQRGAQPGQRLYKNSIDCFQKVFRNEGIRGLYSGVLPQLVGVAPEKAIKLTVNDLVRRHFTDKQGRISLSAEILAGASAGGCQVVFTNPLEIVKIRLQVQGEVAKSVEGTPKRSAMWIVRNLGLVGLYKGASACLLRDVPFSAIYFPTYSHLKKDFFGETPANKLGVLQLLTAGAIAGMPAAYLTTPCDVIKTRLQVEARKGEASYTGLRHAASTIWKEEGFTAFFKGGPARIFRSSPQFGFTLAAYEVLQTLLPMPGGKKEETMAGVGDVVSAVTKGRALDASPFARSRNALKIILDLDEDFGRSKIPDANRWKSLPKVMGGGGGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Y8</accession>
    <name>A0A7D5V3Y8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g098920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546455.1">
        <property type="nucleotide sequence ID" value="XM_014690969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Y8"/>
    <dbReference type="GeneID" id="26240878"/>
    <dbReference type="KEGG" id="mbrn:26240878"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="391" mass="44050" checksum="DF219CC9E3575065" modified="2021-02-10" version="1">MTPEEERQAALDSYRQKLIESREWEAKLKNLRLEIKDLQKEFDRTEDNIKALQSVGQIIGEVLKQLDDERFIVKASSGPRYVVGCRSKVDKEKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNDQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHAQSVVLDGDIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDSINQDDFNKAVRKMGEAKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V434</accession>
    <name>A0A7D5V434_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g100260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V434"/>
    <dbReference type="GeneID" id="26240746"/>
    <dbReference type="KEGG" id="mbrn:26240746"/>
    <dbReference type="OrthoDB" id="5415072at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="125" mass="12839" checksum="9914C6507EC57C9B" modified="2021-02-10" version="1">MGNICGKEEPDTSPPGRVLGSAPAAQRKSTVPRKVGGPPRTLGTGTGTGIGPGEATTSPGDAGDARRKAAEAAEARAKASSKPGGKLQSQLSAQKRQSRADTLKQASAEEQRRREIANNEATTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V544</accession>
    <name>A0A7D5V544_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase metallopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g108510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543995.1">
        <property type="nucleotide sequence ID" value="XM_014688509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V544"/>
    <dbReference type="GeneID" id="26243382"/>
    <dbReference type="KEGG" id="mbrn:26243382"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="6">
        <location>
            <begin position="145"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="348" mass="39225" checksum="E84C62EAB6B57D51" modified="2021-02-10" version="1">MAASTSDWRARLAAVPVPRPSFSAQSLNYFNPSATAGIPITANDCGIFEPPRCTELVLTKGLSALVYLTNNKVVEVIAFSITFKTVHSVVNHSLASFQHQLGTLGREPSPLRSRPTSRSPHSDRCVTEQHAKTDPCSAQIGFGDHVPRWAPGSVLTYVICTETFPSPDDASYATNQLTEAIHMWMGVGATFKQVRRDRKATFRVVYRPKHRPDTEDVLANAFLPNGGRRNQRTLHIYALAFSDTHVDYQANILAHEIGHILGLRHVFAKEKEYKWSAKWGNGCQNSVMDYYTHSSLLRVQQQDLEELKAFYDSPMTEYEGKPVINFVPRSSVYPNVRRHRKRKAKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5U2</accession>
    <name>A0A7D5V5U2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglA_1</name>
        <name evidence="3" type="ORF">G6M90_00g105650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541552.1">
        <property type="nucleotide sequence ID" value="XM_014686066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5U2"/>
    <dbReference type="GeneID" id="26245802"/>
    <dbReference type="KEGG" id="mbrn:26245802"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF53">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="306" mass="34427" checksum="7C4D36588AB649BC" modified="2021-02-10" version="1">MSWKDKLKGLKADFESMIHPRDQAQDQQPPPPPMASRPPPGPSPSFHTYWVPRLYPDTPVHVEWDAKLGNGPDGWGNQELEHYTAAPENSFHTPNGQLVIRALANNSSPSPEQKYTSARLVSRHTLERDQGVLTAVITSPCAEGIWPAFWLLPQEPFSWPVDGEIDIAETWNGDHENRTCLHWGQHHEADKHRVLGTKIPDMHARPVRYDFAWQQPGGQPGQGRMIWYIDGRPVMKAPIPEGTRPMREMTILLNVAMGGNVCAGKTPADGYYDMVVYTMYLASELEHGGWERFESDWGSAPSGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5X2</accession>
    <name>A0A7D5V5X2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein SERAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g096290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI73939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546705.1">
        <property type="nucleotide sequence ID" value="XM_014691219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5X2"/>
    <dbReference type="GeneID" id="26241128"/>
    <dbReference type="KEGG" id="mbrn:26241128"/>
    <dbReference type="OrthoDB" id="4934182at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="73667" checksum="DBD49FB711CE1168" modified="2021-02-10" version="1">MASSLDTRYCVFEEDGGSGNLGQRNTNDTDTRTKATHVEFLSCGIIATVSCLAYGTWDGKKAAMLVLQFRLRAPEGNFRFKRAELSLKFESQASDQAHPVIRRVRPKNNRTTISSLPSQASLRSPSPSTQLPSSGTQTPNSFVLWPAARYSISNTEWLGKSEDEPNQVGWRLMEPRQSKLGICDAIPLGVIVTFSGPFRAEVRANATSFLGAKLDNWPWSRDDPLLFDGVTTKGWQLAATDFLEMSDQDLDTFLIEEGRGGPLSCNNTLSPSKPIEAQAHMVGEQSTKVYRAQGIPSDMTYEDFIQTVSNILKLPKDSVEVKAFSSKEKTAIMSLSCVSPEMHACAFDKSWQIQIPTIDTSDNKLHAFTSTIKFDRDFLGFTSLGHSNDSLKANVDIIAVHGLGGHAYGSFKQRGNNFMWLSDALAHDLSQMTIANRPIRPRILIYGYNARVDDSNSFQSIKDLSIQLRRLLREIRRDDPTRPIIFIGHSLGGLLIKELLIQQCQSENDIDGSSFASCIECLFFGVPNRGMDISALLAIIGSRPNTDFLTSLSIDSAFLQDQATLFPETFRSRDAVVYSFYETCVSNTAKMVDGKLAMTGDPVVLVDEDSATHSRPWEMEGTDHRIPIRRSHADLVKFEQYSPDYVMVQGCIRDVLNRHYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6D5</accession>
    <name>A0A7D5V6D5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cbf5</name>
        <name evidence="15" type="ORF">G6M90_00g108160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544029.1">
        <property type="nucleotide sequence ID" value="XM_014688543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6D5"/>
    <dbReference type="GeneID" id="26243416"/>
    <dbReference type="KEGG" id="mbrn:26243416"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="14">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="13">
        <location>
            <begin position="277"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI74279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="484" mass="53531" checksum="007CF32307BE8EEF" modified="2021-02-10" version="1">MTMEVVKSLKEEEEHTIKPQAVTPAVDTSSWPLLLKNYDKLLVRTGHFTPIPNGCSPLKRDIKSYISSGVINLDKPSNPSSHEVVSWVKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGQAQLARALETLTGALFQRPPLISAVKRQLRVRTIYESKLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDENKHMVTLHDVLDAQWIMDNTRDESYLRRVIAPLETLLTGYKRLVVKDSAVNAVCYGAKLMLPGLLRYESGIEHHEEVVLMTTKGEAIAIGITQMSTVEMSTCDHGVVAKVKRCIMERDLYPRRWGLGPVAQEKKKLKADGKLDKFGRPNDSTPAKWTSEYKDYGAADASTAAAAAAAAPAPTPVKVEKIKMEISTPPADDGEKKKRKKHEGETADEKAERKRRKAEKKAAKAAKKAVKGEAGSDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6Q7</accession>
    <name>A0A7D5V6Q7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FOLH1</name>
        <name evidence="7" type="ORF">G6M90_00g110420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543817.1">
        <property type="nucleotide sequence ID" value="XM_014688331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6Q7"/>
    <dbReference type="GeneID" id="26243204"/>
    <dbReference type="KEGG" id="mbrn:26243204"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="336"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="524"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="776"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="902" mass="100822" checksum="3B811C9625C3287B" modified="2021-02-10" version="1">MPSDEKTPFYDPVPPTYDEALASGSRRGYVWDPARSSIDNRDADEVEQQSLLRQPETAAGPSRQPPRGYRPPTVETDDEFSLLGSDSELDSDEEAAQIRREMQEMEVEEPSTSIGSVWSKRIGFSLSLPKWKWSWRPRLPRFRIQLPSRATEPTRNENEAETETSTDTPRQWPRMNSMALIIVFARLIALLIVLGFIYFLFATGFFSGFSTRLPGGLRFDPEDLKAFLQSNVDPMRMRASVLHYSHYAHIAGTEGDYAMAMDVESMFHRAGLESVQLDKYYVYVNYPRKDGRAVQIMDTDGKTAKWTAKLDEEERGGEAAGRQTYAFHAHSKSGDVKGPLIYANYGSPGDFQKLKDEGIDTKGAIALVRQMGTQKDVALKVKAAELAGFAGCLIYSDPAENGFVKGDVAPKGRWMPEDGVQRGSVSLKNMGVGDVLTPGWESKKEKQRMAVEDAPGLVKIPSLPLAWRDAKVLLQQLKGHGQQVPDGWKGSVPEVDEWWTGDHSSPVVRLQNEQDEIEKQPVWNVYGKILGMEQTSNSIILGNHRDSMAFGASQPHSGTAVMIELARIFGNLLSRGWRPLRTIEFMSWDAAEYNMVGSTEYVEMNLDTLRQNAYAYINLDAAITGTQFTAAGSPPLDRALIRALERVVDPFKNETLKYQWDSRKATLQGLGGGGDYVPFQDIAGTSSIDLKFEGEPVPFGSSYESFNLVEQVIDPNFIYHGLMGQVVGLLLLDLADRAIMPFDMVGYARSLNHWVHDLEYWVNKQKTAKDGASKIPFQELKDAVELVKSNAEEFEKWELEWDRSILSSGGYEANGLGTQRINYNDRMAAFEASLLDLELGGGIPNRTQFKHVVFGPQLWSTYDASFFPAIRDTVEAGDWELARLLTAKTAALLRKAATILQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V720</accession>
    <name>A0A7D5V720_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g107550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544087.2">
        <property type="nucleotide sequence ID" value="XM_014688601.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V720"/>
    <dbReference type="GeneID" id="26243474"/>
    <dbReference type="KEGG" id="mbrn:26243474"/>
    <dbReference type="OrthoDB" id="5379885at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="68534" checksum="3D36AF8AD7547996" modified="2021-02-10" version="1">MDSLAGHLQVPPDRSQILGRQSWKTRYIAVGSRQSTTRNRQGSYGFTQNGSIGRVNTVISKSVQKNAIDEQCLFIYKTKEDWEPIQQWPLSCVSDCQVQLVSHRKQGPVLPTLVVTVSDNQRKRRSSRAAGFISSNKDAGVTTLWFRTPPDNRHPTLHEWSRFIMSKKSSHSTTESPVSPVFTSPFQTRSNDNPDYSPRPGSGSRGLQHKSSTATHSTGPLDRATTFSSGSPSLRSKRSDISSPSSNNHPSQKVQYAIPEQHYTTIRPGDIVSSGPNGEYQGQFIEGWTSAQGRSSMMSSPSRGRDSISSHSRQLSILDEGSPPCPGETILDRAFQLGHIPGAGSYVPGQEKLSSIARFDALMRDAEEKRRKRDTIQQAQQTTMTSAFDHDDSSDDNGADPASDDSDSERDGYSQRRNQNEQHGALLMSPSAQRALAYIAGRHDGGTLKNPKSHRPGMSRNNLSFHADSAPTSTIIAPPSRPHTAHAKSRPKASRAQTTPHLIATATAAPDLPSMTSGKAQQDSGHHRSSTTAEKRHSNSSAKRLSFTEFAKRLSSTSSLLLVQTNASGGSSRASSEVDAQPCSSAPRTNLTLRGTGPLPPRPRDREDQDRRCAWRSSVGMVGTEGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKR1</accession>
    <name>A0A7D5YKR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylinositide phosphatase SAC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">inpp5f</name>
        <name evidence="4" type="ORF">G6M90_00g011110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549409.1">
        <property type="nucleotide sequence ID" value="XM_014693923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKR1"/>
    <dbReference type="GeneID" id="26238853"/>
    <dbReference type="KEGG" id="mbrn:26238853"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF7">
        <property type="entry name" value="SACI DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G15890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="253"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="694"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="942" mass="104810" checksum="13666D8EF8103211" modified="2021-02-10" version="1">MPGISRKILICAAIDGLILQPLPTKGQRPFQPARIRYGDSSISAVPRDQIPDTSGPNSSFEVFGVIGLITVSRLSYLITITRRQQIAQIFGFPIYVVTGVAITPCNTKQEADESIRRTASLLRKQTPNGEDGDSESSDEDVEIPQSPLDEVEDTIGEEDKTRPDSSRSSVAEDVMRRRGSYGRFAQRWFSNSGWTMDQRRSLGLSIATAGSPTTLEASGEPATSKTPIEEDMSDQSQVTALLPKLLRTIQVFFESSRSFYFSYDIDLTRSTSQQAWVPNPDTPLHTQVDNKFFWNRHILGKFIATGQDSISLPLMQGFIGQRTFVVDSDPPQMDEGASESMELADMSTSGSLPVSPPSGRVGDHADLRPSERKCLITLVSRRSTQRAGLRYLRRGINEEGFTANMVETEQIISSPTWDDSSPIHSFVQIRGSIPLFFTQSAYSLKPVPVIQHSPESNYRACKRHFERLHSNYGSLQIVNLVEKRGVEEPIGTQYEANVSRLNEELGENDKIPFEWFDFHHACRGMKFENVSQLLIKLRGRLEELGSTTQVGGEITQRQAGVLRTNCMDCLDRTNVCQSSFAKHMLDLQLKGDGIDMSAQLDQETRWFNTLWADNGDAVSKQYASTAAMKGDYTRTKKRDYRGALNDLGLSLARFYSGMVNDYFSQAAIDFLLGTATEKVFDEFESDMMTKDPAVSIAKMRQRAVELCQKRVVADASEEVHGGWVLISPNMADVVKSWPMEEVVLLLTDAALYLCRFDWDLDKVSSFERVHLGNVTHIKFGTYITSTLAPAHMDETKNVGLVISYQPGKSNIKRTNTRTLSTKGYIAPNSASQGEAKTQVGLVSFFSPKAKSPAVRRLAFKAPYMDSSTAVSGTAGLQQTELQQVITICAEIERLALEAQLRKEGEGEKSFVEKGEIISLQEAKKNTGLLEQLGHSIKRLVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMX1</accession>
    <name>A0A7D5YMX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g015340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548992.1">
        <property type="nucleotide sequence ID" value="XM_014693506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMX1"/>
    <dbReference type="GeneID" id="26238436"/>
    <dbReference type="KEGG" id="mbrn:26238436"/>
    <dbReference type="OrthoDB" id="4140442at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="33552" checksum="AFA5C69F27EF4E6D" modified="2021-02-10" version="1">MATFSRGIALLPLPLPLRALPRPAHPVGSTRFLTTSLRRLRAPQSASPSAKPAKKPPSSPPPAARGSPTTAAASRYAFIKSLSSKQTPTVLYEAPSHFWFYFGCWTSGTAILAWTALTGPTVVEQPDGTPQWVGYVFGASYVLLGAMGFYLLSKTPNIVGAIRVLPPTTGAAHPRLEVTVKRMLPVLKPRTVVAPLENVRLKSRFSLPEEYVPELRRLELRMREEERRQALRKFDMEHLLTMPFRRLGRAFANMFRGVRSAWTDMGFGVLSVDGKEYKVDVTKGFAHDGFKTLEQIVAVGYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPR9</accession>
    <name>A0A7D5YPR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">mst2</name>
        <name evidence="18" type="ORF">G6M90_00g039470</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547301.2">
        <property type="nucleotide sequence ID" value="XM_014691815.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPR9"/>
    <dbReference type="GeneID" id="26239864"/>
    <dbReference type="KEGG" id="mbrn:26239864"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="517"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="198"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="846"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="937"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI67700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120430" checksum="282E32DB6E31B8E6" modified="2021-02-10" version="1">MEEELQQSVMLSEDGEYDTADTGDQAPSSLTHAGLQKNGDVDVSGSEDEELSDQDASGEELDQDASGEEDNDRMDQQIVVGSATPGHGEEYDEDAEGEDDLDEEVGAVKVKPVDSEDEDMGSDGSDAQSAAEEEESDDEEDEEDEEGAWEEGDAGDEDEESDAVQSNTCMFCKQDEENDPSEDFEAFLACTRCGENAHQQCARDAAAMTEKNNSKRWKCPECFNEEESESEDDDDDADDIDAISAEDGEAPPGSERSHVSKTGVDSSPVALANGSSGDRSGTDELVLEDYPIDGPRPMRKRKSASAEADDATLAIRKRRRNQSIDGTDRDDSAQDSRSGDAARAASSRITRLKVTRPPPVTIEKRSRTSLVIKIEVRPGNLKEILSRRKRDRRRVGGSSARPPQAPRSTPARPPPTPASTGNLPALISTMPTPFTSESYSQPFYSFFDKETEEMKGRPYGGILTEAEADTSKTLPSPEDRKKFEHAKQKAEDEWRARVLAMQAEADLPIRKPKKASDNASQIECIEFGGWEIDTWYAAPYPAEYSRNRVLYICEFCLKYMNSDYVAWRHKLKCGTKHPPGDEIYRHESVSIFEVDGRKHPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVLCEFDDTGYHFVGYFSKEKRASSQNNVSCILTLPIHQRKGYGNLLIDFSYLLTKAEEKTGSPEKPLSDMGLVSYRNYWRLELCRYFLGYMESDTRKREGLSIKKISTNTGMTPDDVVSALEGLRALVRDPQTHLYAFRVDLDYCRNYVSKWQSKGYVQLKPTALAWTPYVMGRSNVVNFELGPPINTIAPREDDEAKIQEGATLTAAHARGMQSTLNGVDKSDSQPEPTLASQQGSEQPALPVKSIEKVKTEDKENADPEDQGMVDATTKVEPESWDAPYRDIPASRFEIFPPVPGGRRDRIRPSVSRPSAPRNGSSSSARPRPRSRPSGSARRPAASRPRNNSSRRKSGGTGRGPGRWPKGTKKSDYGNADSGPGLPPGWREKQARLKALAEGRDPGAAENPDEEPAQDEVRVLVSTAGTNQSKAANGSSKVSRRDSDSRSEAGKAASDGEDVDAEGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPW9</accession>
    <name>A0A7D5YPW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 4E type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Eif4e2</name>
        <name evidence="3" type="ORF">G6M90_00g003610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542015.1">
        <property type="nucleotide sequence ID" value="XM_014686529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPW9"/>
    <dbReference type="GeneID" id="26245046"/>
    <dbReference type="KEGG" id="mbrn:26245046"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="337" mass="36627" checksum="70763C7A95500853" modified="2021-02-10" version="1">MDNLWNRRTNSGKLSLSTSTNGPNGSSAGDASRNSSVPRRHGGDISAHGKASPFNTPGGNLASPTSGASSAFGLGSGAFASFGSAKTPKSAGNPFDTAMGSAVAKTTAVKDSGKAAIGKAPSMASIAENKVSSLTVASKAHPLKDAWSFWYRPPISKAHGFIEYENTLHGIATVQTVEEFWEIYSHLKRPSTLPVVSDYHLFKKDIRPIWEDEVNRKGGKWVVRMKKGVADRYWEDLLLSLIGDQFGDAGEDVCGAVLSMRNGEDILSIWTRTAGGRVLKIRETMKSVLNFPPNTRVEFKTHDSSIQQRTAIEEQRREKANQNQGGDRRHTQRQSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQD4</accession>
    <name>A0A7D5YQD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549871.1">
        <property type="nucleotide sequence ID" value="XM_014694385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQD4"/>
    <dbReference type="GeneID" id="26239315"/>
    <dbReference type="KEGG" id="mbrn:26239315"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="248" mass="28166" checksum="57177D18BC367B76" modified="2021-02-10" version="1">MDKEAPMNETLRAISKARQEGKYSDLLLACEDEKMPVHKIIVCPQSPVIDKACNGPFKERETGIYEIKDASIDTVRSMIDYMYTRQYSPTTQPDSVEPSGASYPIVFHARMFELADKYMVVGLQTLAASEFNKAIEQETDVCKFLRSVPEIYSLASTASDKLREAVVWEFRCWIACQEFDATVKEVLREVIGKVPQFTEELLDSFLDSTLLDECSCSEGRTKRIRRALDMPKCDVCGHYCPRVRVNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQQ0</accession>
    <name>A0A7D5YQQ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polycomb protein eed</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eed</name>
        <name evidence="8" type="ORF">G6M90_00g007610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986070.1">
        <property type="nucleotide sequence ID" value="XM_066129632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQQ0"/>
    <dbReference type="GeneID" id="26239193"/>
    <dbReference type="KEGG" id="mbrn:26239193"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="477" mass="52113" checksum="F1EDC3D4EE9BDCB2" modified="2021-02-10" version="1">MAATDGSVFELPKLRVSIGFENDTRFLGHDDNVAEFFDIKFCPYQPLDCDPVFAAVSKKHIVICKLSPSTGESNPCAIINIIRDDDDEASGCCCTWTKDPVSGTPYICVGGVDAKVKIYDVSDGSLVECFVGHGGDVNDLATSPIESSIIASASDDTSVRIWSLDPIHKEQPCLCILAGEGHSWNLLSLWTIPDLPMDAITTPLQVHYPHFSTSAVHSGIVDCVAFYGDCVLSRACHDNVIVLWRIEGFSSEGLPPPQSAAPTPQNVVPTSYEDPDRLTRSAFVPATSPQCPSQYTRLLEFHTPNCGPQFFMRFKLFHVPDQNPVLAFCNAAGNIFFWDFRRLTVYHEVMAGLQGKSKAAVTPSWLKPFTPRQRADAMGRFKGVGSDRDSLASGQTGQTEASEYSPETLESWASRYSTEDPHEPLRAHKTESSSTNFVGRQAAWSPGGEWCVVVGSSNTMLILQRWAKGAPCSRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRM0</accession>
    <name>A0A7D5YRM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g021140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985654.1">
        <property type="nucleotide sequence ID" value="XM_066129867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRM0"/>
    <dbReference type="GeneID" id="26237877"/>
    <dbReference type="KEGG" id="mbrn:26237877"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
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            <begin position="62"/>
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        <source>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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            <strain evidence="1 2">4556</strain>
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        </source>
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            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Peptidase M24 domain-containing protein</fullName>
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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            </authorList>
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            <strain evidence="3 4">4556</strain>
        </source>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="7 8">
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
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        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
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            <end position="356"/>
        </location>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI68341.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="42107" checksum="BFB3386546359D88" modified="2021-02-10" version="1">MSDSSRGSGAQTGGPETSLGQSPSPPSSVPSPSPNTTPSSPSPPSASSPSPSPSPSSESPQPQPQPPATTSSSSSSPPPAPVPTTPSSSPSSTPQPETPSPSPTPTSTSSTSSTPPPAPTPSTPEPTISSSTVVTVTPASSTTTKIVVNTTTPTAGPSSTSASVSGSSTATPINPAGDGNSGGLSQPAKVAIGVVVPIAAIALLALVGLFWWRKRRARQESEEERRKEVEDYSYNPNADPTIPAVGLGTDNYEMRDEGGSGYRGWGSTTAAGSMGRKTSTTMSGGMTAGAFSDGGGHTRGNPSETKTDPTVDGSSSPDGEIMGAMGPSAANNRGGDVHRGPSNASSSYSATGRSEGSDVGIYANGGGYYDQYGQNPYGDQRAQELGGQAVIRDNPARRNTRIENPSHYPQQSAGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU15</accession>
    <name>A0A7D5YU15_9HYPO</name>
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        <submittedName>
            <fullName evidence="6">Phenylacetaldoxime dehydratase</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="primary">oxd</name>
        <name evidence="6" type="ORF">G6M90_00g028190</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541343.1">
        <property type="nucleotide sequence ID" value="XM_014685857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU15"/>
    <dbReference type="GeneID" id="26245978"/>
    <dbReference type="KEGG" id="mbrn:26245978"/>
    <dbReference type="OrthoDB" id="3359285at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="355" mass="39984" checksum="93CFDB31469C88B4" modified="2021-02-10" version="1">MACPARTYPLRQPPNHKPPIPRWQLVWGDNVRRVFTAYIGIQPLGAPKAAVDKAVKDIQSWLDEPSAFKPQAFESFGVINGDDTRDSRVWACYWDNEAHGKEGLQRLNLPSIYSTLSTSEPSAIGLWSESFATPVSRLETNYTGLDYLPGIAKLPDTTTEQHDLTAYWGAARDRIPDSAHDLFEKEDAADTKPEFVQDPTGKRLVGTNYNNMVHIRSGQYWETCGPEETASYEDNLEPTLDKGLQYLWDNRDVSGAMGLRYLRNTDGSDKVLKETCGAGFFCNLQNLEDWAKSHPSHLAIYTGAIRHAKKFGDERKFRTWHEVSILKKGEASFEYVNCLPVTGVIPFLGLREIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVF2</accession>
    <name>A0A7D5YVF2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasomal ubiquitin receptor ADRM1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adrm1-a</name>
        <name evidence="8" type="ORF">G6M90_00g100110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVF2"/>
    <dbReference type="GeneID" id="26240761"/>
    <dbReference type="KEGG" id="mbrn:26240761"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:proteasome binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="389" mass="41979" checksum="E3ACE73667F7C02B" modified="2021-02-10" version="1">MPIAPIITFKAGQCEVDDGSSRPLKVKPQPQPGYLYLYSEDDLIHFCWRKRDQTLDEPELDLVMVPTDGSFVPHEQNSNSEPTAKTNGRIFVLKFASSSQRYLFWMQSKPQSRDGNPSWFSPRDRKIGDIVNRLLQGEEVNVTSELASVRNVDDRDDDDDETMEDVEGTRGQHAHHGSGSGGAGPDATGGDVREEGEESREGGADGARAASSSAPDAAAAVRNFLESLRGQQGLSGGHQQQSDVPYPYLNHLLPTAITVPVIDSAAPEYIDSLLSFLPPSVIVLATGTAREESQKEPSAHAIEAAKASLSLDDKRSLLKKVLRSPQLHQALGVLTMALRDGGLPGVADALGIRVENGGYMQGSGMPLGGGQAVKVFVDGVRKTVQERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVG8</accession>
    <name>A0A7D5YVG8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane GTPase fzo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fzo1</name>
        <name evidence="14" type="ORF">G6M90_00g013810</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549141.1">
        <property type="nucleotide sequence ID" value="XM_014693655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVG8"/>
    <dbReference type="GeneID" id="26238585"/>
    <dbReference type="KEGG" id="mbrn:26238585"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="257"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="472"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="895" mass="98046" checksum="EBF3F8E4A1528855" modified="2021-02-10" version="1">MSQDYFTGKGKGPLRSDPDPDAPKNSSPSSSSRPHYMTVGSGSTSEHAARLQNMLDVDSGYGGSVAGEDHHMAMTSATNSTSDSSQHPRGRASAGHQMWYYRQRAILGRSINKVLDLLQSLQQMNTEWPAHYPTIRPADATSSERPGMGRTYSVSGDAASSSSTTAQPPLLRRSLTAADASTAESSRAAKNRPAPEPRLVSPQIAQELSILKLDLKLGALHQAELVHSLEKNSIAALLDGKISSSIRHLLSLRERIEDTSSKVLITGDLNAGKSTFCNALLRRKVLPEDQQPCTAIFCEVLDARENAGIEEVHAVHKDCTYSRHDETTYDVYALTELEKIVTDNETYTQCKVYVKDIRTVDESLLNNGVVDIALIDAPGLNSDTTKTTAIFARQEEIDVVVFVVSAANHFTQSAKEFIYAAAAEKAYLFIVVNGYDTIRDKERCQKLILDQVSGLSPDTRKESSDLVHFVSSNAIPAGPAPPGGPGGNGSGSSSGGGGGDDPGDDGAKGKGKDLDKIRDFEALEASLRRFVLEKRARSKLAPARTYLLNILNDIHSLAQVNEEVAQSEIDRVSAELREIEPQLASSRKARSEVSEQIDRNIEETCQDVYDHSRSELNTAITQAGRTNYDVPYPGVFGAFQYADDIKEAMLSHITDAVTRCEEYGREKSVQGVNTIKQLGLLHVGDEFQNLQFRPDVMFRRKRDALARQVHIPTELWDFVDWSTLLQRQEKFAGTGMALTVAGAVVPRMLGMSNWMDHAMLTTRVLSNGNLRQLIVPGIVIAAIAGVAYVLQQIPNSLPPRLATKISSQLAELDYIHANSSRISSSVRKVLRFPADSLRVGLDQSVKDLGNKRDEADKVRHESEEASKFFHELVGRSQVQRSMVEAVDLDAPQELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW62</accession>
    <name>A0A7D5YW62_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g087380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542380.1">
        <property type="nucleotide sequence ID" value="XM_014686894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW62"/>
    <dbReference type="GeneID" id="26244894"/>
    <dbReference type="KEGG" id="mbrn:26244894"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="180" mass="20599" checksum="688A480634EB6789" modified="2021-02-10" version="1">MPPKREDSQLSQDSVMTVTPEDRHEILYFAYGSNLSTAQMRQRCPYSTPIGLGRLDGWTWLVNERGYANVVRAASGGGSCGVYGLLYLLPPQDEERLDACEGVPWAYEKVTCDARWVRDAQGRVLDEPVRALVYVDKSRVRESVPRDEYVARMERGIEDAVDNWGLDREYADGVMRRFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWK0</accession>
    <name>A0A7D5YWK0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">sla1_1</name>
        <name evidence="18" type="ORF">G6M90_00g110020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SLA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987842.1">
        <property type="nucleotide sequence ID" value="XM_066131800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWK0"/>
    <dbReference type="GeneID" id="26243241"/>
    <dbReference type="KEGG" id="mbrn:26243241"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF19">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="369"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="126"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="687"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="828"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1068"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI74220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1089" mass="117408" checksum="70621B044EC07272" modified="2021-02-10" version="1">MGFLGVYTTIYDYEPRAEGELAIAEGDVLYVLEKGEDDGWWKAKKKAGMEDEDEPVGLVPNNYVEEAPIVSHARAIYEYTRQTDEELSFPEEAVLQVFDTSDPDWILVGLDGEYGFVPSNYIEMQEGTTQDSPSLPAPPALPVRPHSVAAPKESPSNTTSSLSTPAAALASVIQGKARASTQNPSSPPTQQPTGYQTQHDDSRPSEDREDNPEPRSPALPSRPRPTSTIDDTPERSSSRLEAREAQLTEEPYRTPGGFHMYNINEMVSVMGKRKKMPTTLGINLGTGTILIAPERAEDDPPQEWAAERMTHYSREGKHVFMELVRPSKSIDFHAGAKDTAEEIVAALGELSGAVRAEGLREVIMASSQRRQHKGHVLYDFMAQGDDEVTVAAGDDVVIIDDSKSEDWWQVRRVKNGKEGVVPSSYIEISGITSPPASSNSGIDSARATVEQNRLEEIRLTKEAIRASKEPQQVGHGTPLPERGSSLVAGENGNNSRQQRSRRENGRNEVGNHHKSKSKPDISKLRTWTDRSGSFSVEAQFLGLKDGKIHLHKLNGVKIAVPIAKMSREDLEYVENVTGISLDDDKPLADVKRTKLMDRRPAEVGASVSKNPKPEYDWFQFFLSCDVPVGLCERYAQAFTKDSMDESVLPDVNATILRTLGLREGDIIKVMRTLDMKFGRERNVQDSEANAGGLFSGPGGALRNNTRKGRPAPAVQTSDVVDAAAFSKDDVGSPGPSSQNAASPSGTGPTRTDNKKSGFDDDAWDVKPSSFPAGTTDKPAKPVAAAPAMQPTTASNSGVTLTGSIKELSLLTEPLQPSKVEAVSAAELRQPVEQKEEPSAQNLPSVSPTFFSTVPSSNGTGPLASQAITGIPPRLARQRPAPPSISPNQTSLVSPPPQRPLSAPHSAQSATFSPPALAPQMTGSVQGQVAPPGQSLGDIAQARLQQQYTSQFQQLQPAMTGYISVQPPGITSFSAGIPGQQQFMHPMTTGIPGNLNRQAQFVPIQTQPTGYQASFPSSISGFPQGVQGIQPQQTSIAGGSSFVQPLQPQKTGPPPPVRFGISSDPKKLTPQQTGRRANLSQATPDNPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXM1</accession>
    <name>A0A7D5YXM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tyrosinase</fullName>
            <ecNumber evidence="2">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TYR</name>
        <name evidence="10" type="ORF">G6M90_00g037350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="2"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547096.1">
        <property type="nucleotide sequence ID" value="XM_014691610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXM1"/>
    <dbReference type="GeneID" id="26239659"/>
    <dbReference type="KEGG" id="mbrn:26239659"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029018022" description="tyrosinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="9">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="533" mass="59485" checksum="A72D84B872124B18" modified="2021-02-10" version="1">MLVKSATALLAIGLAPLLASAQFSITGAPVAANGNVPLRRNVNDLYSEGGPQWDLYIQALASLQSMNASDPLGYFQVSGIHGLPFIEWNRGGARNNNGWGGYCPHGEALFLPWHRPFVLLFEQLLVEHAAGIASQYPARYRDQYVAAANNLRSPYWDWSSDSNVPPCTVPERVFVNVPNGQNLGRIEIKNPLSTYNYPREALDGQFGYFTQSRQMVRCPAPERYPDTASQELQDYRLKQATYDVFSTANNFYQFAVRGRVHHLEELHNDVHYSAACRGDFFDASLSGFEPLFMLHHTQVDRLWAYWQFINPSQASFSGRYRGQSRFSTPEGTIIDQNSPLQPFFDSKRKYYTPKSVSSIKGMGYTYEGLEHWRKSPAQLRQDSVQIINSLYAPASAFAKRGGPQTKTRHFAHVELDRAQVERPCSIKVFVGGKQASTIPVMLFPANGNLRSSLAIDKFLTKGSSSNGTLESIEHLIQVEISKSDGTVIPLDKVDSLNITLEQASITPAASRNEFPKITDAKEHAAKIQAYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYI9</accession>
    <name>A0A7D5YYI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA splicing factor CLF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546222.1">
        <property type="nucleotide sequence ID" value="XM_014690736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYI9"/>
    <dbReference type="GeneID" id="26240645"/>
    <dbReference type="KEGG" id="mbrn:26240645"/>
    <dbReference type="OrthoDB" id="5352000at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="78098" checksum="ACB6B80272B6B4FB" modified="2021-02-10" version="1">MPAPEPSKSLDNSCTVVYNGTLYSYSPEGFVSIRLEDGAKWNILDSGVKVTGASCVGSARPKNIDPAFFVVGGQADSEDYPGLQKFTYSTGKWSTVQPTNMVTKHRQWHSSTYIEATDTILVFGGNQDGKSGPSADTFIIQASEPYTVTIPPPPAVPSNQPPASLRPILASATDADVILVGGGDNPDNTKVYWFSVGGNWRYTDCSLAEPIKKDTSSIQGTVVSGEDGSKNLILFDLSQSPNQVSRVVILDGNGKSLTNSPVITSRDVDRDKRDLTLANWPKYNSSLAPKETRENYAMARGPNGMVVFSGGNPKDSIALFDTANNGWINATTFFDSTQKVLSSTSTTSSATSTSTLFTSTSSSSVAAATSTTAAALPPVSDTPEDSGPSSNAILGITLGSIAGFLALLGLILFLLRRRRKQLDHTETGRPSHTPSEEKDMFAFNKSPLSPPPHFKGHRPQASAESYSSVAILMGRMNKEKSGLSRKPSNDTARSSVSSLHKQLKSKISKPIPQNMVHPSLQIYEERGVAFDPSVAEPRPRNGRMEANDGTRRSSGWNRYWSGGSALQILGFGSGKRNTMTSEQSSRYSDVTKNPRATQDSATVPPLNFEGRPAVNSVNSGSPVVAQYVSQMPFTEGMSGTIERPVSPVSSGYSSGIPESINEIWDPMEASKPWGANRAPSSAYGPSSYMTSEAPGDPPAVQPPSGVSRQPQLAMASTSDMSWLNLGDQSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYJ2</accession>
    <name>A0A7D5YYJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Taurine hydroxylase-like protein SAT17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SAT17_2</name>
        <name evidence="3" type="ORF">G6M90_00g052390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986760.1">
        <property type="nucleotide sequence ID" value="XM_066130538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYJ2"/>
    <dbReference type="GeneID" id="90967775"/>
    <dbReference type="KEGG" id="mbrn:90967775"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000011">
        <property type="entry name" value="Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="45314" checksum="2CF70DCA3C0B1BAF" modified="2021-02-10" version="1">MAAQVTGQSGQPDIAYTPNLEIYQQRLKRRQDTEELDKTLPDGFPHKLHSHMAWTSTTVSDQYGWLYELSEPDLDEIQQALDIFKDTGKSLGYINQQTFPLPTLHSRLRSVSNDIHNTFGFKVIRGIPVKKYTREENIIVYAGIASHVTTRRARQDHQFNGRPANVVLDHIKNLTLKLDAKHIGSPAYTAEQQGFHTDAGDVIALFALADAAEGGKSYIASSWTVYNELAATRPDLIRTLSEPWHVDGAARFGKSAPTSRPLLFHQAATASNPERVIIQYARRAFTGYWGLPRSSHLPPITEAQAEALDALHFTAQKHALALEFQSGDIQFINNLSILHGRGAFRDTPDKQRHLLRLWLRDDELAWDTPAALQSRWRRLFDDITPESQFFPLEPSIRSTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ59</accession>
    <name>A0A7D5YZ59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g020970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548450.1">
        <property type="nucleotide sequence ID" value="XM_014692964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ59"/>
    <dbReference type="GeneID" id="26237894"/>
    <dbReference type="KEGG" id="mbrn:26237894"/>
    <dbReference type="OrthoDB" id="2129288at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16651" checksum="7597207935499CAD" modified="2021-02-10" version="1">MPLWKIYHSADAFTTQEEKDAVARGATEFYVSKGLPSFYVHVIFFPIANENKFTGGTSQSRFVIIELAHIARNWDGDQKRATVIKDSIDRVMRPFTIDKGIHLEYAVLEGPAALWRIDGIDPPEAFGPDEQEQAEVNRKILHDKYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZT9</accession>
    <name>A0A7D5YZT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endothiapepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EAPA_2</name>
        <name evidence="9" type="ORF">G6M90_00g030760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986280.1">
        <property type="nucleotide sequence ID" value="XM_066130073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZT9"/>
    <dbReference type="GeneID" id="26247572"/>
    <dbReference type="KEGG" id="mbrn:26247572"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028863899" evidence="7">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="90"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="407" mass="43744" checksum="3AD33E4867348E70" modified="2021-02-10" version="1">MKTTNILVLLAAAINSSRAAPAQNTGLKFSAETTHVSSPHVVHDMRRVVRKFLDQATVKALQSAVLSEREENGTVVTIPEPNDEGVDNLYLTEVSIGTPPQKLMLDFDTGSSDLWVFSSDTSASQVKGQTLYKPSGSSSAKRLDGQKWSIHYGDNSTSSGIVYSDVVTIGGVSVENQAVESAQQVSESFSSDKQNSGLLGLALDKGNTVRPSKQKTWFSNIMPRLSEPLFTVRLRHQAKGSYNFGYIDESQYSGPISYTPASTDELGHRLFQSTGYAVGNGNFKKHTITGTADTGTSLLILPLEVVRTYWAAVPSAQPARLPQNAGYVWLFPCDTTLPDFVFAVGSGRVTVPGKDINYAKNDGSSCVGGIAYYSGLNGLAIFGDVSLKSGFVVYDDGNKRLGWAKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZV0</accession>
    <name>A0A7D5YZV0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g047910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544907.1">
        <property type="nucleotide sequence ID" value="XM_014689421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZV0"/>
    <dbReference type="GeneID" id="26242248"/>
    <dbReference type="KEGG" id="mbrn:26242248"/>
    <dbReference type="OrthoDB" id="5977668at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.20">
        <property type="entry name" value="Protoporphyrinogen oxidase, mitochondrial, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF42">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="236"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="502" mass="55790" checksum="5F52D311B178BF74" modified="2021-02-10" version="1">MNQRQRQGEATDGSSRKSRVAIIGTGLAGLTTAYLVHHDERKRYGVTLFEQADTLSLDAASITLSNAKTGKNERVDVPPRSFCKGYYNNLCRMYEHLGIGFQRIRLVWVYTKASATSQYEPPPEPRDAETIPDSYFVYNRRLHELLLLSPNFWHSSLRQILQTFYLAICHMWFFVACFLLQPWTSQSEPCSDVDADTKSSSDSETFHHYLQRIRLPRQYAVYYLLPVLSIICSCSHAEMMDFPASDVVDFVKGSFFRKTFVPQGGVNRVQSTLSKGIEDVRLGARVTQVTRVDQGMLVRWEQAKDGRSSSSEEIFDRVVLAVSPNVAATIFSPSRSTLGVIPTAPVTSSILAPPSGGVSLARGEGQTPSGECSYRGGDAQIMEFRTAFHGGTAQSESFHFLPSGVVIRTSPSACIAESKGSLHTSKFTRTLRTIRSRSMVERVMGKDTSAHGSEDVWVNGKDNVWIVGSWCWDGLVLLEGCVVSAMKVAEDFGVSIPWSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZX5</accession>
    <name>A0A7D5YZX5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lplA</name>
        <name evidence="6" type="ORF">G6M90_00g032070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543142.1">
        <property type="nucleotide sequence ID" value="XM_014687656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZX5"/>
    <dbReference type="GeneID" id="26243943"/>
    <dbReference type="KEGG" id="mbrn:26243943"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="62"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="397" mass="44998" checksum="71924274A6E9919F" modified="2021-02-10" version="1">MSRWGPSMRRFTSALKTTCHQTRLFSVEAAAHHANKTQVYISRSNDPLLNLSVEHRLLQTTPPESTILLLYVNSPCVVFGRNQNPWLEVNLSRLAQIVNRPDEIGWKDSAVKLVRRRSGGGTVFHDLGNVNFSVICPPQAFDRDKHAEMIVRALKSLGRPTTSVNKRHDIVMDVQLDGKPAHSTFKISGSAYKLTRLRSLHHGTCLLRSPNLSNISGMLRSPAEPFVKARGVDSVRSPVRNVDLDVEVFKDAVVGEFAKMYGDFDVQTEFDSRASQDQRIASGYEELRSKDWIYGQTPRFTFCTHPFEEDPRHRPELSFDHKLHFEARHGIIERFSIGGQQNFSEQQLINRSLHDISNWDTQLFQAGLGRKDAYDVGSWMNRILGTEFTQISSPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZY9</accession>
    <name>A0A7D5YZY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione hydrolase proenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GGT</name>
        <name evidence="3" type="ORF">G6M90_00g068750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540017.2">
        <property type="nucleotide sequence ID" value="XM_014684531.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZY9"/>
    <dbReference type="GeneID" id="26247237"/>
    <dbReference type="KEGG" id="mbrn:26247237"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="335" mass="36476" checksum="D61E83EBF4595006" modified="2021-02-10" version="1">MAPAIELARYGFPVSKDLAIDFAPEGHRVRYGEIITRKQYVDTLKTIANQGPKAFYTGPIAEATIQALKGRNSSMEMEDLKNYSIGYGQQKGLSNPGFVALNEYTTNIISEKTSDWIRTKISDYQTFNDDYYDVDGTELLKTPGTSHIVTADTSGLSVSMTTTINLYFGSHVMVPETGVIMNNQMNDFDIPSERNRFGLDSNMANLIEGGKRPLSAISPIIAKTSNNELLFLIRCAGGIRITTANIQNAIHLLDGRITVLEALSEPRLHAQLGQARNVTIEGGYDNGVIGFLDSLGHGINRGSAQSSAQGLRRLPDGSFEAAAEPRQCNSGAYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0E7</accession>
    <name>A0A7D5Z0E7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g111090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543753.1">
        <property type="nucleotide sequence ID" value="XM_014688267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0E7"/>
    <dbReference type="GeneID" id="26243140"/>
    <dbReference type="KEGG" id="mbrn:26243140"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="76"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="43616" checksum="6A42B5E0F6273E09" modified="2021-02-10" version="1">MHTRTILQAACVVGSTYVNLIQAQTLAINNVGVIDMATGQVQESQNILINGNTIVSMQSEAINPGAENNFDATGMFVMPGLADMHVHLYFSNNPASFATTDNSVLPALLANGVTTVQDLGSNCDAVKNTVLRIGQSQLLGPRIFTTCEMLDGADSQFETVKRLEDPEAVESEVQNLMAQGVNKIKVHLRPSRPVFQAIAAACQKNNIMFGGHVPDSIDAREAVDQGMNFIEHMSRIPPDDANLTQTIGEKQLWVTGTLIQGPSQRRLGLANNLRIAGARMLAGTDTPQGRGLCPNGATHTELKLMVKAGFTPLQALQTATTNAYESLNMLSQLGAIEPGKMADMVLLRGNPVENIDNIDAIAGVVVNGTLHDNEALDKMLSDADVVNQLPFACGNKNATKPRAAACCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0T8</accession>
    <name>A0A7D5Z0T8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539758.1">
        <property type="nucleotide sequence ID" value="XM_014684272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0T8"/>
    <dbReference type="GeneID" id="26247423"/>
    <dbReference type="KEGG" id="mbrn:26247423"/>
    <dbReference type="OrthoDB" id="4868140at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="29102" checksum="0070FB9F12710B6C" modified="2021-02-10" version="1">MEGIVLIQTSSTLKTQNQPPLSPGSSWDSTITIASSPSSVSSYDGNDDDGCNSFSDSGELPSKSTDKKLDIDLGLSTSSTMQLEAGQEDPERTPVPTPLDVDRLHALFSEYEKLVNGQGIPREREASPDENNESSYSDQTEPRQKAISYPTANVARKQQRGISKVKTKQRKKVTSRRTSCTKRALASSVHEYEYMHLGEARRVTNGSIEVEVFWAPIFLPCNQLRGEQAIEEAKNLVTNKFGHAAWEREMSKLDCVDTQGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z178</accession>
    <name>A0A7D5Z178_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g049090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545020.2">
        <property type="nucleotide sequence ID" value="XM_014689534.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z178"/>
    <dbReference type="GeneID" id="26242361"/>
    <dbReference type="KEGG" id="mbrn:26242361"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="759" mass="84713" checksum="49AD52F49DE03171" modified="2021-02-10" version="1">MGDSMLETEAPVPSGKGPPKKRRRVVVSCTECHRRKQKCDRELPCANCRSRNRETFCSYDPSACTSDNGNTTNNNINNSLTTKISPSTQVPQISASSTTPKVTEPLSAMAATWGYGQTGASTISFLKKIETAPSSDDQSSLSTLSLACTSRQDSFAVRERYKDLIRHLPAKVFIDKLVAMCMREFNWQYYFVDPDVFFAQLQEWNNLPFSIFSTEGPRGIPPGLRVFPAVLFQMIAAALLVLPDDEEEEFVTLKYAANMTFEDLACDYSASGAEIVGLFGKKGLSVTTVQAEFLRACFLKYTANVTESWHMIGTAIRDAQELGMHRDSLDPKPTETSLESVIENQWLIERRRKMYMILAMWDINMSLILGRPGTVDWRHSIPSLPIDTPVPSNRSNTPIAPRNPEKDPPTPLTRCLWLHEITLPLRDIQDLEHEGPYPRDFSKIDRVHQKIMTLHESTPAILRLKNPDTRWDNDPEVEGWIGATRYYFHFIHNFTLMALHRPYLFHRKESRLEALTAGLAMLEMQRSMFEGLPSTSWRNFMLFFGTFDAIVLVASVYILFPHDHPEHRQLSVQHIHWAIERFVTMQHRNPLAKAAQGVLRAILGKFTKALAHSASPSKTCITPASTRGPSDNTPASGSARLDANANPAPIWPVSSLPGASMAKSAVEGEDAGNARQDTPGETWLSPSEWAFAPDGLSNIMPTFAISDLIYNDLTAVQDGGGMMAAAEMAPSEGGAPEWQFGGDIAEGTLWQVLNRFQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z199</accession>
    <name>A0A7D5Z199_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleoporin SEH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SEH1</name>
        <name evidence="13" type="ORF">G6M90_00g022100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548343.1">
        <property type="nucleotide sequence ID" value="XM_014692857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z199"/>
    <dbReference type="GeneID" id="26237787"/>
    <dbReference type="KEGG" id="mbrn:26237787"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="314"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="424" mass="46700" checksum="933E7181DFFEF129" modified="2021-02-10" version="1">MAASGPPSPISEKQAFDLNLQHGHKDLVQAIAFNTYGDRCATGSVDGKIRVFNRHKDGTWRLCDTWTAHGGEVLELQWLPATIYPNLVASLGIEGWFRLWAEDPSAAPGRRFCAGRSVGGRPAFDTRSTRAPYRSFSMKHNEETRHTYLALLATDGRLTVYENDQPENLSEYTSIDEFSVCSKPNRGEEASFKVRFDPNPEPCYAALRAGVGADSLGIVVAGMDTVKVYRSRDIVTASYGVAQTQKEFYLAAEIHGHRGLVRDVAWAPGNIRGYDVIATACQDGYARVFRVDTPFSDDDGKSWSAGDLLKSRGHTLSARDSPTKDEAAEKHPHPSTLSASLAKSGNAGDRQWSGQPGQVHHTHREISRLDSHRTPVWRVGFDDDGQIFGSTGDDGRLLFYRQTPDGVWAKSSELVMVKARMATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1A3</accession>
    <name>A0A7D5Z1A3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Citrate/oxoglutarate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">YHM2</name>
        <name evidence="8" type="ORF">G6M90_00g034540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546851.1">
        <property type="nucleotide sequence ID" value="XM_014691365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1A3"/>
    <dbReference type="GeneID" id="26239414"/>
    <dbReference type="KEGG" id="mbrn:26239414"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="115"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="220"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="34142" checksum="135354B1FDE5762C" modified="2021-02-10" version="1">MVASATLPAPIGEPQKLEKKPIKFSNLLLGAGLNMFEVTTLGQPLEVVKTTMAANRGDSFATALGRIWARGGPFGFYQGLIPWAWIEASTKGAVLLFVASEAEYYARAAGASEFGGGILGGITGGVAQAYATMGFCTCMKTVEITKHKMAAAGVKPQSTFQTFMDIYRKEGIRGINKGVNAVAIRQMTNWGSRFGLSRLAETWIRSATGKSEKDKLSAMEKVIASGLGGGLSAWNQPIEVIRVEMQSKKEDPNRPKKMTVGNTFRYIYSNNGIKGLYRGVTPRIGLGVWQTICMVAFGDMAKTYVEKVTGDSVSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z203</accession>
    <name>A0A7D5Z203_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Highly reducing polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Bref-PKS</name>
        <name evidence="11" type="ORF">G6M90_00g079450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539917.1">
        <property type="nucleotide sequence ID" value="XM_014684431.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247255"/>
    <dbReference type="KEGG" id="mbrn:26247255"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="67"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2329"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="981"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1013"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2411" mass="261656" checksum="B089CBDE4B87C2DB" modified="2021-02-10" version="1">MTQVKNIQASVANGTNGQAGHMDHGRSNGSYPSNGSNHTNGTNGHGLLGAAATRSDGHGPRADPSVQTPVAIVSMACRLPDQCHNPQQFWQFLLDGKIAINTPPGTRYDLATHYDGSLKSQTMASPGGMFLQGVDPADIDAKFFHLSGVEATSMDPQQRQLLEVVYEGLENAGVTMEQLDGARVGCFVSSFASDYGDMQARDPENRASATVVGVGRTMLSNRISHSFNLKGPSMTIDTACSGTLIGLDLAMKYLHTGEIESAVVAGANLYCSPEHVMDHYMGANGAASLSGKCHTFDAKADGYIKAEAVNMIYVKRLADAIRDKDPIRAVVRGTATNSDGWTAGIASPNPVAQSAAIRQAYRNAGIRDLAQTSYVEFHGTGTRAGDSIEASGIASVFTEFQSPERPLRIGSVKSNIGHSEPAAGLSGLIKTVLSLEHDVIPGNPTFVDPSPKIDFEKLRIWTSRTATPWPAVSLRRASINSFGYGGSNAHAIVDEAKGFPRHHVSSYHDQSRLAVAEEEQLDQRQRIMVLSANSDKSLQGQFSALDKHLSDPSVCVQQRDLAYTLGERRSRHYHRGFVLASDHYLDAEAFETDHVRDEPLSVAFVFSGQGAQWPEMGRELLANFPVAAKTVKQLDDVLQKSYGAPAWTLYDELTGPRSPDHMRLPEISQPLVTALQLAILSIFDAAGVSCRAVAGHSSGEIAAAVAAGLLTPEQAIKIAFYRGKATSAVEHAAPVGMMAVGLGPDTAQKYLDGSSAQIACFNSPQSITVSGLRSELEQLGQRIKDDGHFARLLQVDSAYHSRHMNAASDAYMELLERHVEWETRSAPTGTVMFSSTINKRLGESPGADYWVKNMLSPVLFSQAVTSMVQAESEGINYLIEIGPSNALSGPVNQVQKAAGTSLDYTSAWKRGVGAMQTLLECAGKLFNAGSGISLAPFNDDGLPDPPTFVSDLPNYQWDHSTKYWHESESSSDWRFRKFVHHDLLGSKILGTPWTRPIWKNNLRVSDVTWLKDHTLGDSIIFPAAGYIAMAIEAMYQKSKVLGAIPDDAAVVDQTYKLRNVAFPHMLTLNEHAGTKLVLSLEPCSSTKETWHEFTISSIPKDGNGALEEHCKGLVSIGEHARHVATADDVGPLKFGVPGSVWYKAMRDVGYFFGPAFQPCQSIEAKADARNCRAIIKLDTPPSRYPQSKYAMHPTAIDGCLQIATVALNRGHRSALDTMMPPRLIDNLVIFQQPDHVERGIVASEAMWSGVGRPDDNKRFYSDIRTYAEGSNQTLFHLQGLRYHSISASADAPHVFTQVQWAQDASFLTPEQLSAVMSAAATSNTAPMAAVAKAVSIMAHGKPTSKILEVLYEEGQQDTARSLWLDGLRQLSGPIAEGCAYTLSAPAHKASLELREKYTSETNVTHVVHEADCLTASVADDEKFDIVILRASTITTALVKALEGARQAVADGGYLLVLNDDAVGTKVDRIKEVDVAVPGYNTVKLSGDGPSHVMFFGIASNSASQAEDSADKVVNLVHFKTSNGSTDAARDALAKQGWQIVEQSLSLDGIVDKSTVLVLDEMFSPVLTDLLDEQFELLRGLLERECKILWVTKGSQMEVSTPELSLMFGASRSLKAEYPRNVFVCLDVESNDSHASFGAIDRALKHLRKLSEVSKVDSEFVERKGVFYTSRVVSDEAVNKLEHDSQHGADKVKDIIGGHQSTIRLISDRTGTLDTLTYTEIPDMPPLKDDEVEIEVRAAGMNFKDLANAMGFVPANERLFGLECTGVVTEIGRDVTTVKPGDRVLMVRRDGGCFGNKVRNRWHAVYLLQDWISFEQGTTFGIAVHTAVYGLVTMANIQKGHSVLIHSASGGVGLAAIDLCKYIGAEIYVTVGTEAKRDFLSENYGIPRDRMFSSRSVSFGPELMRATGGRGVDFCLNSLTGDLLHESWRCIAENGSLIEIGKKDMLDRNNLSMEPFDRNCSYRPLDLSRPSITDETTRKTGEYIMDLIAHKHIKPLHVCKVFPFEQTVEAFRYMQRGKQIGKVVISYDKARTTPIEYRPAAPRLRLRADGSYLIAGGFKGLCGSLAVYLARSGAKNIVAISRSGYEDEKSQKTVYDCNSLGCSVDLVTGDITSLDDVRRAFASASKPVVGVIQGAMVLRDRMFTTMTPGEFREPISPKVDGTWNLHRASLEQPTPLDFFTMLSSVSGLLGQLGQSNYAAGNCFLDSFAAYRIQQGLPANAINLGPVEEVGYLKDKDMLGRIFESRGWKPINEALLHRIIRSSILLQTGKVNPQQAGQLITAITPGNPPFEAVHRFSSLRAAAGTSSGSSGTASSASSKLAILKGASKGGVAQETLLAAATELLNTVLMRSLGIDESIDPMRLLANYGVDSLVAVELRNWLRAELNVEISALEIVGSRTLTTLSESILKKLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z255</accession>
    <name>A0A7D5Z255_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g082930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543515.1">
        <property type="nucleotide sequence ID" value="XM_014688029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z255"/>
    <dbReference type="GeneID" id="26243692"/>
    <dbReference type="KEGG" id="mbrn:26243692"/>
    <dbReference type="OrthoDB" id="10367777at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028881832" evidence="1">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="243" mass="26480" checksum="7D2BD8DF34D404BA" modified="2021-02-10" version="1">MKSAIILASTAALASALVQPKPAVGAQLPSAKGVDESSYGKRTSDICLETEAKVVKKEATFEEWKKVCGAEGLCNAMHSEPLLWRTIPELYGWAFARACPPSPAESEAEAEPAPSQLGCLETEVKAIKKEASFDEWKQVCKTEGLCRALHNEPLLWQTIPELRGWAFAQACSPLEPSPAPVQSGCLETEVKVIKKEASFDEWKQVCKTEGLCRALHNEPLLWQTIPDLAGWAISQACSSENRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2F6</accession>
    <name>A0A7D5Z2F6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protamine P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g031990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543134.1">
        <property type="nucleotide sequence ID" value="XM_014687648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2F6"/>
    <dbReference type="GeneID" id="26243935"/>
    <dbReference type="KEGG" id="mbrn:26243935"/>
    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113928" checksum="7E0CD3701C0FAD51" modified="2021-02-10" version="1">MAGDRGISAELKETWGDDTVYSASFCQPEDVLYEGSEDEDYDNSAARRRRYEEAGQRFLDGAVPLLFSAALRGPFDRRSGFINPWISHRHSGTARSSTGSSRPIEKVASSQSKNSVRKPKPDPTLPARSADCHLPSPESLKQAPYTQEHPYLAADGIEKVNTWREQVDPFASNKNGFWVSDDAKVSTSIRKRSAPGSEWLKKVSAKRHQSTTTQKRPPRQEQEDDELDELMADLPSSSFENAAPVMSPSKRRSPRNAMRRTSCKVLVESDDELSPNKTAAATLSSPVSLRNGPVISASSKRSQPPIYITSSIGTQTTPSRLRHVKVLDTWSKNRSPSQEDPPGEEPRVKVEAASGQDIETTIENISKSRSVTESEPETIADEDDNGSAMLVEDGCIIVNTTCEDATSQATNGQHENQRYEPESPPSNCKAEMDGNSEPIAQRADSDIEMDNLPGIKSEPQGVAECTVPDSTRNSTGPDNNRNPDDSPVKETDIPVAQSHGNWVMKMESVGEVVAHQGGADVKQEDNLSDMDSGDDSGNSCAATQKTFSIRNIEPNRSQDTSHASTSDDIAVHDEKTASMESEFSTTSTRDYHTQSDSESVKHETPTTPRQAERVKEDASEFIFKTILNRFVPSSPWNKLTRLALSPSSSPSATFSKKCAVANESADQVEEADSQPSQTHKEELPSPRRNELIGDFDQLHKPVQIQQTVSYSHSDRRLKDSEADDQRVPESQQSPWVNTDHAILSRSPLGILSLNISGAKPSSNEAENTAAVSPSTNIQNPWMQNPSSNAASLDQSSSSPINENIEQIPFAKPSLPRPRTPEPQFCVKSFSSFMSPSPDRNRGEGVSLSASGQVFRSTQGSLPSSVKSQWSQKRPGLRVSWAASLEEFEGTPSREDARIARHMPKRQTSPPPENLSGDFRQAHDTKFAKHFEAVANRRDGRSQTLIPTESQQLQSPGPFAMAETFMTADNNTAGLVSKDRESAEHTEPRACSRASEEPMDVVEDMVREMGDFWDPWNIDAELDQARKGASGGQTSSIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Y4</accession>
    <name>A0A7D5Z2Y4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">VCX1_1</name>
        <name evidence="12" type="ORF">G6M90_00g038240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547182.1">
        <property type="nucleotide sequence ID" value="XM_014691696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Y4"/>
    <dbReference type="GeneID" id="26239745"/>
    <dbReference type="KEGG" id="mbrn:26239745"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
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    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
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        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="98"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="292"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="452" mass="47835" checksum="C9A391B8A18F85AB" modified="2021-02-10" version="1">MSSRSNRFANEQTPLINGESASSAQAGNHTQHQHKTGVRTFLFDREHTPGNDSESIAVRSAAYTWHVTKVTLLSGYVNFLLVMVPIGIVAGALNWNPTAVFTINFLAIIPLAAVLSFATEMLASKLGQAMGGLLNATFGNAVELIVSIVALKDGQIVVVQSSMLGSILSNLLLVMGMCFLFGGLVHRGTNGDGREQSFSAAVAQTTCSLMTLSSASLVIPAALYAVLAQNGSQDKNSSILILSRGTAIILLLLYIMYLVFQLRTHSNLFDEETQQEGEEEEDASIGPVAAGIVLVVVTVLVAICAEYLVGTIDDIVESANISKAFIGLILIPIVGNAAEHVTAVVVALRDKMDLAMAVAIGSSIQIALGVTPFLVIVGWIIGQPMSLHFETFQTVAFAVSVLVVTYTVQDGKSNYLEGAMLLGLYLIIAVAFYATPSDAFDGSFAQLLGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3P2</accession>
    <name>A0A7D5Z3P2_9HYPO</name>
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        <submittedName>
            <fullName evidence="7">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MUP1_0</name>
        <name evidence="7" type="ORF">G6M90_00g003170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI65948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686489.1"/>
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    <dbReference type="GeneID" id="26245006"/>
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    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <end position="533"/>
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            <end position="31"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI65948.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3P3</accession>
    <name>A0A7D5Z3P3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g092740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541918.1">
        <property type="nucleotide sequence ID" value="XM_014686432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3P3"/>
    <dbReference type="GeneID" id="26245386"/>
    <dbReference type="KEGG" id="mbrn:26245386"/>
    <dbReference type="OrthoDB" id="4940684at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028939391" evidence="2">
        <location>
            <begin position="21"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="525" mass="55612" checksum="857C458ABD378A04" modified="2021-02-10" version="1">MLVNTAALAGVLALVECASASALKKRQVLKDENVAARLAGGANIGDQCHPPGTYSLGGDKVVPPCLSEQAIALKCEIVTQLKKNTTSEANLKAYGSCLKDQGSSYFKDVNGCLACKAAHNHMSQAQFEWYSQAWADGQKAFLNDAVPKATAWEYVLGAINNTTCQKNGTNEKLTAWDCWNQLPAGTGVATKNLTIEEYYKDRPKTQNIGSFEFGGKSFPESSSVELGLLVPTFEIKADIGYFCSVKLENGTITGSVNATAKVEILTQYQEITSIFNFTKPDEFTVLPVINAPVPVKDSVTTVSKDEAAVLPAVVCNADCRDKATTIDKIQEAAAQGPKEADKAVVEASKPALQDLKENKPLSVTHKVQIITEIKTEIKAPVNFQGQGQAPPLQNGPGGSNPNGIEAPGQQGQEPAKQQGPGPSDSKGPKSPILNGPEPPKQTGSAPASQKGPEDDKCEEDSEAPAAPPVGGADKGASKEKAKEKPKETTKETANATCEQGDPAKASVKVTICQMPGERDCKTYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3R4</accession>
    <name>A0A7D5Z3R4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inhibitory regulator protein BUD2/CLA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BUD2</name>
        <name evidence="4" type="ORF">G6M90_00g077850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545320.2">
        <property type="nucleotide sequence ID" value="XM_014689834.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3R4"/>
    <dbReference type="GeneID" id="26241353"/>
    <dbReference type="KEGG" id="mbrn:26241353"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="786"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1270" mass="139158" checksum="3F3CB0EF285AD8E0" modified="2021-02-10" version="1">MSSTDMERQKPPPTDAGSDSGDKQPSQIRDTLQSPKQPTVPPPSPPVDAAPDAADLNPSAAAVAAASSLRAAFKPETSSGMRSATPDNSSDGRRLGAGALDSSALEMSRDMQHVSPLTVPRSASRRQGIVLFSDNLDDNSYDGADSAASPLSLQAGTQQGAQLQLQQRHPSAPIRPRTRTLDAAMLMPQRTPTVIDQRHRVGSVSSSGSQPLLDDQRSPVPANESVGYSSTNVSRLQEPATPQTPSKPKEKRSGKRLLKRQASRPSSPVPTPSPSVDSFPLPIHVSEPTKLIMLMKTLGGRMRGEIEYQTEGDHGVWHTGIAYIDDEKGCLMYNSGQAGPFFATLISDLRNCIVLPTNHPDDGKDCLKLLATSPTAEIYLRPVVPEEWNLWLAAFLCWQQTRPLAPRVQNGAGNNIPAGIAGPPIHKTGTPAEGSKAATIIKVGTILLWDKGSTGSANDLVQRSSTRGALSPGATWRRISSILQDNGELKLLLENDISPLCVIQLSQLSRCAIQQLDHTVLDEEFCLAVFPIYSSTATKLSIFRPVYLALDNRVQFEVWFVLLRAFAVPELYTLDANDQDSIREVADLEERACEETFRIEKTIGVRVTEAKVKARPAGLEAHVYEKPFRAGQDPLVGNYVAEVILDGEVRARTTTKLATKNPYWREDCEFVDLPHTVQEVSVVLKRIDGTPDTASTGSGAVQPGPNQESLYGTVHIALDKLQRGKDHEDWLQIIDDKQQPIGSMLIKISHAEQIALLAVEYEPLSEILHRFTSGLTTMISASLPGQLRRLSESFLNIFQASGHAADWLMALVEDEIDGIGNATSMKKFRFSNRLKSNESIESPSERELIVRDMSKSLAGEANLLFRGNTLLTQSLEFHMRRLGMEYLEEVLQEKIAEINELNPDCEVDTSRLSNCSGTDIDQRWNRLIQYTMEVWHCIAESAHSLPSELWHILKYIRAVAEDRYGDFLRTVSYTAVSGFLFLRFICPAILSPKLFGLLRDHPQPRAQRTLTLIAKVLQKMSNMSTFGKREEWMEPMNRFLTTQRPVFRDYIDQVCGIPAESGSVKSVPAAYSTPITILGRLGSAAKEGFPSLPYLIDHARSFASLVRIWVDSRPENVKKGQADGELLIFNELCTGLQKRADACLAQVERTRAANAASRGVAEQLAESLEQATLIESLSVPYSLPSSSGDDRPPGSSGSDGGDESGSRRKSKEWRRGRDGLEYRKAGGLRQVSGMGSATKSSKNGKVGRTILNGIMRIGGRAESPDAKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4G3</accession>
    <name>A0A7D5Z4G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Aquaglyceroporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g077430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545359.1">
        <property type="nucleotide sequence ID" value="XM_014689873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4G3"/>
    <dbReference type="GeneID" id="26241392"/>
    <dbReference type="KEGG" id="mbrn:26241392"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000027">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36472" checksum="9B4E464A55750E94" modified="2021-02-10" version="1">MSILPPTQDSVSESSVGKSVPVIKVDMGASVIHDEPMSGSDMIPAEKQPRWPKIRSIWQDAFSEFFGTMILLLFGDGVVAQVVLSNGTKGNYQSISWGWGIGVMLGVYVGGKSGGHINPAVTLANCVYRGHPWRKFPVYALAQLLGAMVGAAIVYGNYRSAIDAFEGGAGIRTVSGPNATAGVFCTYPAAFMTRTGMFFSEFVASTILQFVIFAMADSNNIGAGPLMPLGLFFLIFGIGACFGWETGYAINLARDFGPRLVTYMIGYGPEVFSFGGYYFWIPMVAPFLGCLAGGGLYDLFIYTGDSPINSPYLGFNRLLKPRRSVWSNTYNKSPESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4R0</accession>
    <name>A0A7D5Z4R0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maleylacetate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tfdF</name>
        <name evidence="5" type="ORF">G6M90_00g067760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540533.1">
        <property type="nucleotide sequence ID" value="XM_014685047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4R0"/>
    <dbReference type="GeneID" id="26246640"/>
    <dbReference type="KEGG" id="mbrn:26246640"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018506">
        <property type="term" value="F:maleylacetate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08177">
        <property type="entry name" value="MAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034786">
        <property type="entry name" value="MAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF105">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="169"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="363" mass="38278" checksum="613B36D75C5A4D67" modified="2021-02-10" version="1">MKEFEYNVLPSRVIFGSGSVKKLPAEIQRLNVSRPLLLATPGKSNFSNQLSDIIQAAAITIAGTFPHAKAHTPTSVTEEATAFLASVAADCVVSIGGGSVVGLGKAVSIRTGVPHISIPTTYSGSEMTPILGETQNGKKTTRSDPKILPAVVIYDADFTMTLPPAICSTSGINAIAHAVEALYATNANPITSMLALEGIKALAAALPQIVRSPESQAPREEALYGAWLCGAVLGSSSMGLHHKLCHVLGGSFTLPHAETHTVVLPHALSYNAPAIPEQMAKLATVFPGSNGDALRGLELLLQELGVPRALKDLGMEEGDIEKATEIAAGNQYPNPRPLEKQWIRELIRRAWAGETAKADLCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5B9</accession>
    <name>A0A7D5Z5B9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alkJ</name>
        <name evidence="9" type="ORF">G6M90_00g045520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986263.1">
        <property type="nucleotide sequence ID" value="XM_066130388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5B9"/>
    <dbReference type="GeneID" id="90967711"/>
    <dbReference type="KEGG" id="mbrn:90967711"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028885433" evidence="7">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="213" mass="22954" checksum="66976E22BA622A6E" modified="2021-02-10" version="1">MNKLILGSAVLAALALPPACATTDFDYVIVGAGTAGNVVANRLSRYPNISVAVIDPGADQRSNPNVTNPMIWLNNLGTSTDWAYKTVPQANASNRVITFDAGKGIGGTSLINGMTYIRGHKAQFDAWEQLGNPGWNWAAMFKYYKKVETIFPPAPAQIQVGASIEPRYHGTSGELHVAFNPALENGPLYDTLRDSWAVMKEDVNRDVNGGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5D5</accession>
    <name>A0A7D5Z5D5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g038160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547175.1">
        <property type="nucleotide sequence ID" value="XM_014691689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5D5"/>
    <dbReference type="GeneID" id="26239738"/>
    <dbReference type="KEGG" id="mbrn:26239738"/>
    <dbReference type="OrthoDB" id="4941028at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34788" checksum="1B3855445DE8A401" modified="2021-02-10" version="1">MEEQYAIPNVLSCVCDDDNESSMDTGDDYHFNDDENTPNTPGGSSQNEGGLQGYTPPQETSPDYEIQENMYHDQSHQDPSQEPPAPWQATADIDDDFESTLGGLVKSLNDEQALLNKKQERVNSGAREVVAGVAKHTFQKHLPQLEKVTDGLQKAYQHLEELAFPQTKNAVTRASQSPLDEGIDKNALKRRLESALKALDTACKALHGVETPAQECREMQPAASYEEQNNALTVPLSACPDAAGMGNGRTNNSSLTGRFDSFRFEEGDNDMHNNMDPLLSSLHLLAADNGNEIMTSNTGGPLLSPMPGWDNQPATYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6J8</accession>
    <name>A0A7D5Z6J8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-containing monooxygenase EthA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ethA_1</name>
        <name evidence="6" type="ORF">G6M90_00g067870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540544.1">
        <property type="nucleotide sequence ID" value="XM_014685058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6J8"/>
    <dbReference type="GeneID" id="26246651"/>
    <dbReference type="KEGG" id="mbrn:26246651"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="501" mass="56189" checksum="1EC7C665C825777A" modified="2021-02-10" version="1">MDAKSEAPSNGLDFDVVIIGAGISGINAAYRVQNEAPAGTSYVILESRDAIGGTWNLWRYPGIRSDSDVFTFSFGWNPWPGRESLASGEKIKQYMVESAQQAGIDKHIRHGHKVVSANWSPDDKCWEVMAQQQGGGEHHDGKATRPPQLFRGRFVFLGTGYYDYQEPLASAIPGIDNFGGRLINPQHWPQDYDYANKEMVIIGSGATAISILPAVANKVKHVTMLQRSPSWYLTLNQYGRIARLLAVIFPDRMARRLNRYRWLIQTQILLFVSRNMPFVAGGLLRLLTSLQLPKDADWKRDFQPRYGPWDQRLCVVMDGDLFAALRSRQASVVTDHIDTVAEDGIVLKSGQVLKADVIVAATGIRLKFGGGIRFSVNGAPVDLTDRFAWKQCMLQDVPNLVFSFGYAENSWTLGADCAATVMLRVMRELQRQRLTWAAPRVDASETKTMAPRPLWRLTSTYLENMTSVFPKGGTGEWRPRWYPFFDLWAASWGGMKGLAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6N3</accession>
    <name>A0A7D5Z6N3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydroxyacid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">haox</name>
        <name evidence="9" type="ORF">G6M90_00g033090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543238.2">
        <property type="nucleotide sequence ID" value="XM_014687752.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A7D5Z6N3"/>
    <dbReference type="GeneID" id="26244039"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L-lactate dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase class I"/>
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        <property type="entry name" value="FMN_HAD"/>
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        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
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    </dbReference>
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        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="10"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
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        <ligand>
            <name>FMN</name>
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        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
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        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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        <location>
            <begin position="345"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="ARBA" id="ARBA00024042"/>
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        </source>
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            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67989.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="43740" checksum="2EE3C7A88225074F" modified="2021-02-10" version="1">MEIPNPASKPRQPDPITVAEVEAIAAKALSKQIYEFYASGSDEQKLLKRNMSGYDRLYIVPRVLRDVSDVDTRVEMFGSKLNMPIGIAPSAMQRLAGRGGEIDVARAALHERVNFTLSSQSTTSLENVMVVKTSQGDSTPTPDFWFQIYLTQDLDKSVDLIKRAEVAGYKALVVTVDTPVLGNRVNERKNVLALPRGMRLANLEGDDADSAKTPTPTRNRLLMDARTKHDAKLVVELGGGEMHASNLSWAKTLSFLRDVTSMKIVLKGVMTPQDARLAILYGADAIVVSNHGGRQLDEAPSTIEVLADIAHAVRGRIPIILDGGIRRGADVFKAIALGADLVWIGRPVLWGLAYDGDKGVGAVLNILERELSRTMALAGVREISEISSAYLAVANPTFGVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7A6</accession>
    <name>A0A7D5Z7A6_9HYPO</name>
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        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g094610</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI73643.1"/>
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        <property type="nucleotide sequence ID" value="XM_014685340.1"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:DNA-templated transcription"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AtrR-like"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
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    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="285"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="612" mass="68294" checksum="6BE72BFC471CB7D8" modified="2021-02-10" version="1">MRLVSTPQPSLKGDVLEGQKSFPKDNDSSHRHVLSDGFQSSEHQSSSSPSESQFLTIAGPASKLKAYPACLFCRGESAATNPQRRLGIAPLGNIYFGGQNFGAICPRNGIPHLTPHCEQWIRERCGQEPRFRHLFSGNTPRSHFSGSDIVPTFVSVQAQVKQPGLPDKWIVHGLVSAFTNSEFSLAFPLMNPVLFEETIRLAYSPDEMEPPLERVTAKACVLAFVSLASSHCPNANGAPYVDMDSCARDAQILLSDIIEDTSITTLQTILMLMLHETLCGRLQASSMYHALACRTVFALGGHTVMLPTPKDRELTMEEHEDRHLRLLFWLCYVLDKDISLRNGQPPAIPDQFCDLTLPEGYAQSRFLPRQPGQMQNPWLPSDLRLSILKSKAVQSLYSHASLRKSDAELLKTIRELDEELETWRTSIPEAFSPNLSVKNDTRLEGVTSMSINMLLIELHLDYHFLLNTIHCASSRCLTRGSSDPQQISFGVQSSFDLSVEASRSTIIYLSMSASRLAGEAFWFFVFYPLSALMNLFFNILQNPGHALAVHDMELLGKTSQIIRSMPIRRVTSHETEYLTKMDNLVAELCRLSKCAIEKHQAMLSSYQAGNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Q8</accession>
    <name>A0A7D5Z7Q8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Invertase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SUC2</name>
        <name evidence="8" type="ORF">G6M90_00g073380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545727.1">
        <property type="nucleotide sequence ID" value="XM_014690241.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241760"/>
    <dbReference type="KEGG" id="mbrn:26241760"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028919845" evidence="5">
        <location>
            <begin position="25"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="448"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="573" mass="63654" checksum="A1A421063BA0273D" modified="2021-02-10" version="1">MLPISTNIHTTLLGALYLANWCLGQNSTQYVGAHVPSGTSIVGSYGGQYRPQVHFSPPSHFMNDPNGMFRDHNGTWHLYYQYNPTKSVAGNQHWGHATSQDLYHWTNQPIALFPPKKNVYIFSGSAVIDKNNTSGFFGNQSNGVVAIYTLAEYLDDGSPGPQSQAIAYSYDSGFTFTPFDGNPVIPSNSSQFRDPKVVWYEDHWVMVVAYAQEFAIGIFTSPDLIEWTHASNFSNQGLLGLQWECPNLVRMPLYTEDGQRRDDMWTMLISINPGAPVGGSITEYYPGTFNGTHFEAVDSVARIADFGKDNYAGQFFFGVPAEEDPVSIAWASNWQYTQTVPTAQEGWRSAMSLPRRNYLTRIDRVGWKLISSPYDMQPIMGRNLAYNQSLVNGSLTVDFSDIASNAVYWEVNVTGLPKKGIPEMATLNFTLLSPITAEYIRGGYYFGGDNPFYLDRGGAKGFDNVFFTDKLSTNSLFCNGSWSMKGVMDRSILELFLNDGVDSATATFFATQPLTFLIISTSSLPHGTRVSTRVNALKSTWQQMEDPGDGLVHGNISMQETASEAMKHLLQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7X7</accession>
    <name>A0A7D5Z7X7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g090580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987265.1">
        <property type="nucleotide sequence ID" value="XM_066131377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7X7"/>
    <dbReference type="GeneID" id="26245579"/>
    <dbReference type="KEGG" id="mbrn:26245579"/>
    <dbReference type="OrthoDB" id="4939174at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="281" mass="32025" checksum="CB40A034AB9ACA21" modified="2021-02-10" version="1">MWWAERPEQGSLRAIIQAHSRKCILVRGIAWTGTHLRILNVRFLRGDEQLANARSMWQTWPGEIAVEEYLRSSLRTVQNTGIRKVLELLDIYNLGIKSLELDFDGRVVDVIHTDGIFKSDTGDSCIAYVNLNTITFLRRAYIWGAPGAPGAQLSPFNTPMIRLRQKKQRRLTPPDLAEDPYILCVLIALAQKQLEDRDQTDEPLRVSLLALPGARASHLYFYTACFPFSFLNKFTEPSLFLECPTVSISYVKMPLDKPEEFLCHLKGVLLETDALETEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z881</accession>
    <name>A0A7D5Z881_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein PLANT CADMIUM RESISTANCE 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PCR3_1</name>
        <name evidence="2" type="ORF">G6M90_00g054340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986929.1">
        <property type="nucleotide sequence ID" value="XM_066130581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z881"/>
    <dbReference type="GeneID" id="26246276"/>
    <dbReference type="KEGG" id="mbrn:26246276"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="197" mass="21874" checksum="B85BE113EDF693E6" modified="2021-02-10" version="1">MAAPQEHVPVTTQPAPTPAPAAAQPANNGPVDQADLDDWKNRFNHVLSRSGEVVNSKSPESAQSWTAGFFDCFNPIDTCLITYCLPCVTFGKTHHRVRKNGNLDGYEPINTSCLLFCGAGCFGLHWIPMAMQRMNIREKYNLKGSCLEDILTSCCCHCCSLIQQDKEAEHREQQLLSAGVQQQYQPNNEMQYPPKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9F6</accession>
    <name>A0A7D5Z9F6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol phosphoceramide mannosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">imt1_1</name>
        <name evidence="3" type="ORF">G6M90_00g096060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546725.2">
        <property type="nucleotide sequence ID" value="XM_014691239.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9F6"/>
    <dbReference type="GeneID" id="26241148"/>
    <dbReference type="KEGG" id="mbrn:26241148"/>
    <dbReference type="OrthoDB" id="4948908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF23">
        <property type="entry name" value="NUCLEOTIDE-DIPHOSPHO-SUGAR TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="40497" checksum="22AFD3135922B11B" modified="2021-02-10" version="1">MASKQLCVTARISLIVALFIISLQLLAHLTASSLRSPSPRDSRKGTPRLARQIPASELLSRRPTDTGGPIPKIFHQSWKTLELPARFRHWSLSCRRKHPDWEWVVWTDEDNLALVQKHFPWLEEAYRGLPGVIYQADLARNLYMYIYGGVYADLDTECLRPTEDLQWAHGPLFNQQGSIPVPATAIFGRMGNDPDFEHSIPNAWMASTPGHRFFLAALQDFMDLYNQTTREGGELPDPESVTGPVALRDALARYESNRVLHGPRINDAVAGLARGGPFPHTPAEEPRVLLLPSHALYAYSWGGDGEDVRDMCWVVNDGFDAGRCKDRLDTRGRGSISITYWSHTHSPTGHDEENMKHIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9N1</accession>
    <name>A0A7D5Z9N1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g104900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987623.1">
        <property type="nucleotide sequence ID" value="XM_066131658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9N1"/>
    <dbReference type="GeneID" id="90968201"/>
    <dbReference type="KEGG" id="mbrn:90968201"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028983722" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7023" checksum="9CD2DBAD8FF81DF5" modified="2021-02-10" version="1">MNYFILAFGVMLLIAGGMHYQRPQLNIQGLIKGKLEVMEPTMGVDSSRKAQEAMLQGQVAATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA42</accession>
    <name>A0A7D5ZA42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g095730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546757.1">
        <property type="nucleotide sequence ID" value="XM_014691271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA42"/>
    <dbReference type="GeneID" id="26241180"/>
    <dbReference type="KEGG" id="mbrn:26241180"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025255">
        <property type="entry name" value="DUF4202"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41729:SF1">
        <property type="entry name" value="GLUTAMYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13875">
        <property type="entry name" value="DUF4202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23144" checksum="9A216266E21F4EB2" modified="2021-02-10" version="1">MALPSLSPAHEQALRLIDEAHSEDPNKVDGPNGPKTVPYELHYAQKMTRWLQSRCPEASPALQLACRAQHFRRWELPRSAFPMTRPGYLTWRAKQKSQAASRVSALLSSPAIQPALPADECERVAALVRKDGLSTDGETQVLEDVACLVFLDDQFDDFEAKAEMDEDKMVGILRKTWGKMTDEGKKLALAMDLSERAKVLIAKALEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA49</accession>
    <name>A0A7D5ZA49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g069430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539959.1">
        <property type="nucleotide sequence ID" value="XM_014684473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA49"/>
    <dbReference type="GeneID" id="26247179"/>
    <dbReference type="KEGG" id="mbrn:26247179"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="5">
        <location>
            <begin position="265"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="815" mass="91237" checksum="290ACA5523DC90B0" modified="2021-02-10" version="1">MAHLTQEERDIVDANPLGDSLGGIREALREAERNTRREASQSDDSTAAPERPRLFVAAIGKIFSILSASDVSLALASRTGREALVSDLTAIRLRVQKGDLKYKQFRPLSQLVIKQAPDVDIWAAVVALVRSISHSTPPPSLPPSFETPITHSSASQQGSEQTRRKIEPRVFEEIRHCTHRAVAGFHEKYFEGHKWNLRARRIWQSVNSRYSDKDKRWTQLPDAATEDEVCGWLLNLQEELLATERAAYFRSNGLQKVGAEASRQLDLFVKMKRDEASDTKHDWKHVLVVGELKQSDQKNKSLWLQVGSAVRNVFAYQPTRFFVHAFTLTGTEMETWIFDRSGPYSGTTFDIHKEPEKFIRVICAYLMMSDEELGLDTFTKAKDNRLLVTIPVEARGKKRKRQLELDPNPIAHQRAIVCRGTSCFLAKATGAAVFDGVVKYSWTSSMRPPEADLLNKANERGVKGLAKLVGYNEEVTSISRLREGLVFSTPHKFRGVSHSANTSFSQSQPPLSQSFSQFPGLSIASSGHRKRKSTDGSSNASKRSRPNSQVADTERKENGATYPAQEPQGTSLVQQDHDQTPYANRIFRVLAISPAGRSITQFKGVIELLEGLCDAIKVHRSLYTDGKILHRDISENNIIITDPENADGFKGMLIDLDLAKEEGKGPSGARHRTGTMEFMAIEVLLGISHTYRHDLEAFFYVLIWLCARRGWALSRASGRRPKNSMLSRWYTGGYEDIAQSKRGDMDKNGLEVILREFPEVFDGVKPLCRAIRDVLFPHKDGLFTGTPQDPSTLYDPIIKAFNDTIAGIGLGEAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB09</accession>
    <name>A0A7D5ZB09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prenyltransferase ltmC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ltmC</name>
        <name evidence="6" type="ORF">G6M90_00g105030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541492.1">
        <property type="nucleotide sequence ID" value="XM_014686006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZB09"/>
    <dbReference type="GeneID" id="26245742"/>
    <dbReference type="KEGG" id="mbrn:26245742"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028906852" evidence="5">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="340" mass="38285" checksum="C49CC4095C6F0C9C" modified="2021-02-10" version="1">MAWLTGRFMAGEMAAVLSAFALGYLVRNRCHDKNTASQTVKHYGYDKSRSLESNSEAVDKLPSCPYEYLLGIYGRHHFAPFVKAFSPTLKNDDPDKYALILDIMDAVHFCLILVDDICDDSTKRKNQTTAHMLYGSCETANRAYFVLTKTINRAMRERPVLGVELLKALEQMLEGQDISLVWRRDGLKAFGFAEEDRVPMYRNMAQLKTGTLFVLLGRLLNDGGDQLDDLFTRFGWYAQLQNDCKNIYSDEYAVNKGGVAEDLRNGELSFPIVVALNDKHVHSRIEEAFRSRSEGDIEKAMAGLQSPSVKKACLEALQDAGKGLDKLVAVWGRREQMKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBU5</accession>
    <name>A0A7D5ZBU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L33-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl35b</name>
        <name evidence="4" type="ORF">G6M90_00g108870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987786.1">
        <property type="nucleotide sequence ID" value="XM_066131763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBU5"/>
    <dbReference type="GeneID" id="90968240"/>
    <dbReference type="KEGG" id="mbrn:90968240"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="entry name" value="RIBOSOMAL_L35AE"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12146" checksum="B6880F2D8E86A6D2" modified="2021-02-10" version="1">MPSESGHRLYVKGRHLSYQRSRHVTRPGTSLIKIEGVDDTSAANFYLGKKVAFVYRGQKEIRGSKIRVIWGKVTRPHGNSGVVRAKFTSPLPTKSFGASVRVMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC12</accession>
    <name>A0A7D5ZC12_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Meiotic recombination protein DMC1</fullName>
        </recommendedName>
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        <name evidence="2" type="ORF">G6M90_00g110940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="26243153"/>
    <dbReference type="KEGG" id="mbrn:26243153"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIH holo complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
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        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30839" checksum="83C4FB56D410C8A5" modified="2021-02-10" version="1">MDDQSTIPEPGGFIRQTGLPSPAPSSASTRPLAGLPHPRGHSLRPGSSKEDMVRRYVEERLLHISRRYVKKFGNPNPGDEVVGFKSFGEVAKELDGLVNVLWKSGTPSLQIPFLLKLASDFTQYVRSFPPSPRATFELLRKLDHCFASLLRGQDMDTNETLPGFENGLRAGMTTTDMVRCRSLVEQTRVLIVEVLSSGDVDDEDDEDEDEDTDMDMDGGESAAEAGGNRTPTPWDIEEERLHMDAARIYENTIVQLGERLGDPLGSENKIDSSAVCSTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPI6</accession>
    <name>A0A7D5UPI6_9HYPO</name>
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        <recommendedName>
            <fullName evidence="9">UNC93-like protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ORF">G6M90_00g001840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687408.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244267"/>
    <dbReference type="KEGG" id="mbrn:26244267"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52518" checksum="FD3648E586301890" modified="2021-02-10" version="1">MASTSASAQAKAPLTTTTPAQDVRVKRTWYRTTLFNAFVIGMVGFLAPGLWNAMSALGAGGAQEPFLVNAANALVFGLMGILCLIGGPIANRIGLDWTLFLGAVGYPIYSAGLYTNNRYGNEWLVLVGAVTCGLSAGLFWASEGAVALGYPEPTKRGKYMNIWLWFRTGGPLLGGAIVLALNHDASAKKKGKIDAQTYLVFVALQCVAAPVALLLSSPETVQRSDGSKVIVKAEKSLKEEFKSLWKLTMRKDLLLLLPIFWAAYFNQYSGNFQTYYFGVRARALIGFVSNFGTLLSSQLMSWFLDYDGIRVKRRIELGFYYVVVWHVIAWVYGWVIQEKYTANPPVWDWEDAGFVQGFFVLLLWDFARQSLQNWLYYFLATKTDNISELSRFSGILRGQESFAQAISYGLNTREWKGGRVPLAVNTILLGLSVYPTWLAVRDHVPVEHGEPDSSSQSDETSGRMKVSVDIERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQR4</accession>
    <name>A0A7D5UQR4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SWI/SNF chromatin-remodeling complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">snf5</name>
        <name evidence="7" type="ORF">G6M90_00g013510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQR4"/>
    <dbReference type="GeneID" id="26238614"/>
    <dbReference type="KEGG" id="mbrn:26238614"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="535"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="548"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="748" mass="83544" checksum="FB9AF834273F8685" modified="2021-02-10" version="1">MATQLATSEPAPSVRPTATSATSAPDGDEKDAVQGSSPAEIPVRTKESFNKLMVERYTMRDAIASAALGEQLNQTRQSSQEMREKIHEYRMVRNEYKPWFPPSRLYGEGYNGFGNGYTENQQPASRIIYPAQKPRPGRRTTPSFKFARKDMLKQAEQHEELVPLRLEVEWDKVKLRDTFTWNLHERLLAVELFAAQLVEDMALKPPAAQPVFEQIVQQMREQLNDFYPFAFAEEDALDPELPYSAYKNDEMRILVKLNITIGQHTLVDQFEWEINNPNNSPEEFAANMARDLSLSGEFTTAIAHCIREQTQLFTKSLYSIGHPFDGRPVEDSDLVSAFLQTPLPAVFRPQQQAKEYAPYMYELSEADLERNEMVFSREQRRQKRSINRRGGPQLPDLRERQRTIRTLIVSSVLPGAVEDVEDSRLYKRTAGTIRKRTARDGEISESEESDDSSPDSPAPSQMAGTARTRGMRGAASAAQQRMANIGRSETPETGSLHHHETRTSRRGREETEEPSHLWVTLKVSREKLRRVIKGDYRDLKAPSQPQTPVVAHARAPSASSSIPKPKVPFTPTSASSTPQPAAAPAPTGSGSSSFPAGQLGRLPAPPPVPGQSPPPAVSISSPIVTDHVHTGQSLTCASRQPPPPEWLVNALKDLEKQYPNGDKFEAIMKYSYLDPDTELPLQPQTQPFPEGVKYAWLPRIRCLDCATKLYTPGPDMTAQKFEAHLKFSGHRAKVNQRLAAQNGGASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQV4</accession>
    <name>A0A7D5UQV4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547830.1">
        <property type="nucleotide sequence ID" value="XM_014692344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQV4"/>
    <dbReference type="GeneID" id="26237274"/>
    <dbReference type="KEGG" id="mbrn:26237274"/>
    <dbReference type="OrthoDB" id="4936348at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="639" mass="71006" checksum="F35A24C436EE22F0" modified="2021-02-10" version="1">MSGLDLLARYLRDGLFDDADFANSFVQDQESDSNWALRRSYSAQGHTIREHFNIQLFDQDDIPLVKCSLKLFIQSPDAPQDDTREKIFKPRSWFGPDLDIEVIEQQVDSQHRPTTTTLLPASTSTNSVSQGLTEESVLPSTIPGPEPAPKTLTGKVAIKKDRSLEHRMLTTAKAFVRGIQILVSKPQGNQAKRLRTIRKCFDTSARNEHPIETGQLMRLWMRLKSDKTPIDQICARTTSKTKDLELSVASIKNVGNYIAGITELENARKARDNGSKYLCGRALDRILEAISRLVEYYGSVAITVFTFLEVGGFGVARLGNTAIKGADNERYFYDGLVALIDLSLRRFVATARETEADAISDAIPVLNPVAFHWWYEGEKGRYEDLCQSLKLPAFANATTNIYTERLPSTILDEFSAQSQQARSHDGSHDNNNNVDYANSESGSNSPDKSTDFILHNAQRLAKYMSCNKETYLQSFEGDKEKHGMAKLASRILNGTSSQEELLTAPTDVVYMIVEMLLLDSRSKQGVKRKRASGNEQDKRSDGSSFHHDSRQPVSPVDLLDQNTSGQAAPLTGGMDISQGLPPLDPQFPPGFFDIDFEGMDTNDRLPQFDSQLSLDWANLMAMDSFGAQGSSSGGVFLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQZ3</accession>
    <name>A0A7D5UQZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g011680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549354.1">
        <property type="nucleotide sequence ID" value="XM_014693868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQZ3"/>
    <dbReference type="GeneID" id="26238798"/>
    <dbReference type="KEGG" id="mbrn:26238798"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="110"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="328" mass="35288" checksum="40BDDB048FC19851" modified="2021-02-10" version="1">MTSGPSIIRKSGSNNRSNLELVNSLRDSFSEAKRDYAEGAHPNGYGTGNGVADGIPNGIPNGISNGNGNGNGNGIRSGTSTPPTSVELWTERDGKVLYIPRINWQAAGLREEPNQYEITVKMFLLPGTSVEQRVQYIGEALALVSKELGIQTIDLLVASFPGISFEGTCEWEADKKNANQGNLDEELATWRIFEELHNQGLAKRLGVAEFGSEKLSAFVKRASVPPVVDQINLHDCCNVPPPLKQLAAVHGIELNVHRDCTDILPPGTLRELLGSGPRGANVLADAENGGVGLQGNIVPQWVVRYMAFVRDRGVIENKGYFAGAELAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URT1</accession>
    <name>A0A7D5URT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g003630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542017.1">
        <property type="nucleotide sequence ID" value="XM_014686531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URT1"/>
    <dbReference type="GeneID" id="26245048"/>
    <dbReference type="KEGG" id="mbrn:26245048"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="534"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="683"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="736"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="912" mass="99369" checksum="AF241C13E9A69911" modified="2021-02-10" version="1">MATKQPLKTTFDVEHVIRPIFTGGSIAIDNEAQILATTLGEDVVLTNPANGKHLAQIEGDGEMVSTLTLTPSGSHLILCSRSLSMRIFSLKRSPSDDTVQATLSQTLKPHGTPVVVLAVDRTSTLLATGGTDGTIKVWDIAGGYVTHSFRGPSVLVSALHFFEIAARSKDNKSSRKGKKGVQAEDDSDNEVEAASSVNFRLASGSQDGKVRIWDLNKRGCVANLDSHVSDVQKIDYSPEQHALVSASRDKTLIWWDTKSWKIRKIVPCLELVETAGFIDNGRLTFSAGANGCLRIWDTDNGREVTPAQSERSEEEGIVAGIYLPGLSFILCVQVDHTLAFYKSPTKESEASLGIPEPFRRISGTHDEIIDLGYLLPDRSIMALATNSEDVRLISVAQASTEGASAPWDSHATPYFGQDVALLRGHEDIVISLDIDWSGHWIVTGAKDNTARVWCVDSARNSYTCWATFSGHAESLGAVALPKSVPAEGSAARNNPLDHPPACLITGSQDQTVKKWEIPRQRQQQGSKPRAVFTRKAHEKDINAINIHHSGSLFASASQDKTVKIWSMEEGEVQGILRGHKRGVWSVQFSPAQLPTIQGNDGPVTGKGVILTGSGDKSVKLWSLADYTCIRTFEGHSNSVLKVAWLNLPSQREQSRKPVQFVSAAGDGLVKVWDANSGEAECTLDNHEDRVWAVAVHPETNTIASGSGDSTVTFWKDTTVETQAVASQAALKMIEQEQELENHIFAGSYREAITLALQLNHPGRLLNLFTSVVTNGNPDEGSLCGLKAVDEVLGSLSDEQIFLLLLRLRDWNTNARTAPVAQRILWTLVRSYPASKFSDLSVKGARGQKSLSDVLQGLQVYTERHYRRMEELVDESYLVEYTLQEMDSLAPMEDSNASLKGLDDGQGDAVMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US12</accession>
    <name>A0A7D5US12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549890.1">
        <property type="nucleotide sequence ID" value="XM_014694404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US12"/>
    <dbReference type="GeneID" id="26239334"/>
    <dbReference type="KEGG" id="mbrn:26239334"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="294" mass="33787" checksum="4C96DACBBDD4C8AD" modified="2021-02-10" version="1">MPTYLCHGFRWYRRSIRIFIILNDLEDCTPDWIIGRDTAAFILSQFAESFDFVPRLENEDGTVTRPESNETTPTREKRPQSYDDDLDMPVSKVSAAEDTVLVHEWSPVKLLEEYHVEEAEHASRPYAYVADHVVRVDLGVDIVAEMARYEKTVKQTQSQWFEQLRAQVQAEEQSRWYVVVCDDTDREAPENYDDGDEELPEMEAARQPRPQPQPRPRPQPQPQAGSLSRTGTSSSLAGDRLDSGDALGDSPENRPDVPMKPKFLGQDPFKKELPPTPRLKKKLSIRRLFSKKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US22</accession>
    <name>A0A7D5US22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">paxM</name>
        <name evidence="7" type="ORF">G6M90_00g011470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985981.1">
        <property type="nucleotide sequence ID" value="XM_066129710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US22"/>
    <dbReference type="GeneID" id="26238819"/>
    <dbReference type="KEGG" id="mbrn:26238819"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="426" mass="47206" checksum="2AD56C9C74889E7F" modified="2021-02-10" version="1">MSKVDAEVIIVGAGIGGLTLAAICKRLGITYKVLERTEVLQPVGAGISLAPNALRVLDQIGVYEELQETAQKLQKLQIWRNATQWNSLSLEKLEPTYGYPILSAERHNFHRLLYKAAGEEENVILGSKVVDIVDTPGEPVRVVVEGEKEYRGNLVVGADGIRSAVRRALLRNTGQEASANTIQFTGRVHFSGITSPLPNCGPKELGIANWMLYDQAILTTWPCKDNRQWYIGVKKAEGDVDTNRSVWDSITPADIKKVYGRAFHPFAEEGQFGSIIDKSERVVASNVFQEVEFPSMYNGRVALLGDAAHSMTSFFGQGGCQAIEDAAVLGNLLAENRSTLVEDSELILSTYARIREPRTKDLSRFSDNFALLHTARLPYGTGPFVRWLLYTLVPTWFWINYLGWLYKYQPTVTALGTPSAHGKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USP2</accession>
    <name>A0A7D5USP2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exostosin-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Extl3</name>
        <name evidence="7" type="ORF">G6M90_00g019740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548569.1">
        <property type="nucleotide sequence ID" value="XM_014693083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USP2"/>
    <dbReference type="GeneID" id="26238013"/>
    <dbReference type="KEGG" id="mbrn:26238013"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF2">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="6">
        <location>
            <begin position="88"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="339" mass="38606" checksum="10DD505903129EAD" modified="2021-02-10" version="1">MDASKPLGGIQPRLFKRIATIILAFALSAGIIFGLFTYAPEKYLQQMSNAVGISSGTRPIPRCGDFTGSNEIWKESQTKYRNLRDDKFTIAMQTYRRPKELNDTLHALLSEKIPSLTEVVVVWNDVENAPPPNYQSKHGVPVRYRPSRENSLNQKLWPDPAYKTQAIFLSDDDIYYKPKDLEFVFQTWRKFGRRRMTGGFTRCADRDADGGWKYTGCSTEEGQNYYNMILSGLAFTHISFMDYYSSQDEVPKKIRAYVDEHFNCEDIALNFITSLLSGEGPLLVKGKEPYVSFVPKNGISTKPGHGEARTKCVNDYYDMFKCMPLINETARIELGVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USS7</accession>
    <name>A0A7D5USS7_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g019550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548586.1">
        <property type="nucleotide sequence ID" value="XM_014693100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USS7"/>
    <dbReference type="GeneID" id="26238030"/>
    <dbReference type="KEGG" id="mbrn:26238030"/>
    <dbReference type="OrthoDB" id="3543857at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59107" checksum="BB73FD15656E829E" modified="2021-02-10" version="1">METTLVRGSSDEEPQSSASTTPSPEPTSTKPTFVIEIKAAPKYTPGCGPALQSLRLLPPASSSAYIVERILLPSPGLAADGKPLPKRMTYIVGWHDLPAASLLVPAMDVLDYVSPRTLEEWEETMEEELDQERIRLAGEKKVGFEGLKQRHKARPPTHTAIEPAAAIEPETEADDVVRPKMGAISLSTPQKRKLADFEGLSDNDNSPSNQLAREMFGEDGREDSWDVPSAGLGNEDMRLEFVSDTVDSDGARKPKRPYINTPVPLPSYINGILEYATSSIEPKPSPTPTFKADDASQHPGHTDLVASIEGTTSSSAAGFNAVTGSSIFPNMSNTRESTRDNAAWTPAAGQANSSAKKSTRPKSAKKRHKESPLIEKMAEDGEPTWEVERLEDVAVYDVEGQGLVRYFFVRWAGDWPPDQQTSWEPEGNIPRNLIRNYFKMDKKRRAKLAAQNQRQRGPPERVGWGNSNATSTGSVNEMYQTEDQGDDDLLGAPHTINDKGSLFVGDDLDYDTFYEDESETRDLREKASAALPPLFGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT90</accession>
    <name>A0A7D5UT90_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BOA17</name>
        <name evidence="4" type="ORF">G6M90_00g020760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI65991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT90"/>
    <dbReference type="GeneID" id="26237915"/>
    <dbReference type="KEGG" id="mbrn:26237915"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="386" mass="41991" checksum="3F5AB3EA73BFF455" modified="2021-02-10" version="1">MADEENRPAATHNSPRTWLLTAALSPLAVRLIRQLLSHGDYVVACLPPQEIDHEQRSAEFRELIAECKSSRKDREGWKDRIRGIRCDGNMSSCISAVTDAVAVFGRIDILLCCRSEAVVATVEELSTNPHTQSLARQQFESNFFSQVNFIKATLPQLRKQHTGHIIALTSTCGHLGTPGLSMFSAATWGFEGYCDSLAYEVAPFNIKVTVVQPNMEIQSLTGRLTFAPQIPAYVDAYPAAPNVRDMLSNVLNSDPDTAVPEPLEESGATPSTPGSTSLEPEPGRGGIFDRYPRLTPQAADALVNETVHALTAIGGHENPPSRHIVGSEAALAVKEKLKTVTEEMEDFVDSSLAVDIFESELTEEAKKGKRPRDKSPEAGGSNQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTW0</accession>
    <name>A0A7D5UTW0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g049680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986211.1">
        <property type="nucleotide sequence ID" value="XM_066130472.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26242417"/>
    <dbReference type="KEGG" id="mbrn:26242417"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1362"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="936"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1241"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1374"/>
            <end position="1386"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1487"/>
            <end position="1511"/>
        </location>
    </feature>
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        <location>
            <begin position="1512"/>
            <end position="1524"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1645"/>
            <end position="1654"/>
        </location>
    </feature>
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        <location>
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            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1752"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1806"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1911"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1967"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1986"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2034"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2047"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2106"/>
            <end position="2146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2146" mass="236529" checksum="90F41D76BA2A9D41" modified="2021-02-10" version="1">MTAPATGLIASANIKRKILAFVVSFTNKLRIRASRYSRYDPERRSRSPRDRSPDRFDRASQYGDNDRRRSSAEARSNSSGFPPNRDGFGDSLRREPPRGPKALVDAPSGPRGGAFGADFRGRGRGRGRAWPPRDESRDRGRDRDIDYRDRYREDRSRERERERDRERDRDRDRDRDRDWRESRDFRSRRSPPPGRGRTPPRDFRDRDRDGPLVPDADRSRRGSRDGGPPSAGSSNSDPPFGMLPFGRGGGFMRGGRGRGRGDWPSDRGRGRATYEDRGDRYPRSRSQEARWGRDRDRDDRDRGDRYPPEADIIRRDPRDDPRERNDRDLIRPKKEGRPSISQEPSAQGREVSPPPVAPSAPAFGSVPSRTGADGVPVTTSGSGKLPPSAPRALTDRPGSSGNSAPMESSAPVSGPIRAGSHDGPSIPVGPRAHQQRPSSKQWINPDLKKAPVSPKMMRAQTFAQSGSISRRDSRESDHHHFEQRRPRSSDADTDPRGSGNFDNRARSNHSAEPGEITVKSESERGSVTLESTKTPETGQSFKDDHRPSTASNAAIKPVQAIKRVRKRPAVGVVRFSLPPKTALKDQDSESDDDEDMADYFNMEIEKTEAELARLPKPSLPTEVVAQYAALSHGSMARILNESEGLTDVLGTVTETLDVELSKSHDVVTAPTKDVDATAALIETPVEVTAKVETEEIAKPDVVDTVPEPITKTEEMDLDAPRAPSVPASDVQSKDAVASKPPSRPVSRSGASTSGTSILAHEGTKQPSQPPESIPEATEAASKPPSTPSQIPDDDDETESEDEAYLDLKTVRRFMTTPPIDSLPDYSCDSWVKDKDLLATFDTDSIIDEYVMEHLDKIHLEESTQQEQARKAYADKYIDYLEFTLSNDPAAVKSRDKFSVAVPMIEPAGTITPEPKPEGRSSGRRFASERDLERVLQASMREDEERKERELRAQKEKYRSEKEAVIPEMYWDAEERAKAQYTDRSGYTPQDRLVSTWHVLPPLNNFTEEENELFEKRYLENPKQWGKIAEMIPHRDFGTCIQYYYLMKKDLNLKEKLKKQPKRRKKGGRGKQRSSALVSELGNGDEGTEESQETGENGERRRPRRAAAPTWGFEQPATDSENATPAGTPGRRGASAAARGEQGEKVDGRRGRRRAKDKDKDKDKDKDKDKEKEKDKDTKASKANQSLSVTPGGGSGKGRSRSSSRVPADIPTTAMPPDAGRAPTAGFDQTVPSGIHPPFPVQQQQQQQQSQQQQQLQPQQAIPGMERVKTIPPPSISDVMAAPSLRPEPPPPPQPAMTTFNLAQPQTERKAPAQASSYWSVSESNDFPLLLRSFGSDWTAIAAHMGSKTAVMVKNYFVRQKDQGKTEWDAIVQEADGKRTRGEKRPDPPLPTTGGRGRRYDNSSAVGSTRPLAVAPGMEMHNEPAQQKMEATNQPPRSQPYPGGYGVPIAQAPTQQQQQQQQPAQQQHQHQHPHQQQQQQPPPPPPQQQQQPLLAQPVPGQQQQQQQQQQQQQPPPQPPPPPPPLAIQQHAVPQPASQAMSPGPRPALRAPAQAFGFPEHAREREVVAQAHQRVPLPPKGGGGANQVPELRDQRPLAAAQPIPSAHPDSMLERQQREREREQRDRERELAARQAERQSMRINAEAELAHQQRHYEQQPPPYGHRHQSSIGQGPRGEPLSLSRPSSQEPSRSAAAQPYPPPTMHQQPPPPSHAVRGMMDHPSVAQSPPLGPSSRPMSSLQQRPPPGQAQEPYGHAPPPGPPAPTPSGASRPPTEPRKTSNIMSLLNDDPPPASKRVSEVSNVPSGPSGTPPPPTMGRPPPPGPAPPSQMRREPEPQYSPYGRAATNVSAMPSLKPTAYGGSPGQPPHMGAPRSTMGMPNEPVPADRDPYYRGHAAYQAGHHSGNNSPQTAHRYPPAQAQPQYPPQGGYASYGPGGQPTHAASPPPPQYGGHGSAARSREVPPSGRDNAWPQQPTSSGAWPSQPSKPSQGPPPQQQWAPPHPSSTPKPSTPAQAWASAPPPQHVGMRDDRGAPVYASSSQPPQHSMQSRYPPPGSRGPEPVPPPPAQGYPRYASTPGPGPRDPREHPRSYTPGYDSRGPPPGSGYPAPDPREMQMRDARDPRDPRDPRDVMGRGLRPHEYERHPDQYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU40</accession>
    <name>A0A7D5UU40_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Outward-rectifier potassium channel TOK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TOK1_0</name>
        <name evidence="12" type="ORF">G6M90_00g036180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986169.1">
        <property type="nucleotide sequence ID" value="XM_066130178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU40"/>
    <dbReference type="GeneID" id="26239574"/>
    <dbReference type="KEGG" id="mbrn:26239574"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="225"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="386"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="752" mass="85859" checksum="E45FD7A43850D9D8" modified="2021-02-10" version="1">MDDGKHGKAIEHHASDLDNNLSKQMSRQQLQHKRSRETRFQNDLAHLIPSRWWFASSAFPMIAATLGPVASAFSICALGSQWRQKLVPGQNVDDAVFIQDPAWLTIVNAIQLAVALVSNAFLLLNMTKRVRFSIAQPITIIGWYISAICLLSLNATAAGPLQYNLDPPQDYIWSQAFYYGIWAAILYFVDASLMAVTFWGASSGHYPKDFNLTRSQRTLMLQTILFLMYLLLGALIFSKIENWRYLDAVYWADVTLFTVGFGDFAANTTLGCALLIPYALIGVISLGLVISSIRSMILERGRRRLDARMEEKNRRRFIRTMTKSGHDEILSPIDDDTVSNWGPENAGLPQNEFDRRKTEFLLMRKIQQQASIRRKWMAMAISTGVWILLWLVGAVIFVSAEEPYQQWNYFDAFYFCFISLMTIGYGDRTPNSNAGKSFFVFWSLLALPTMTVLISNAGDTVVKFVTDATIRIGNITILPGEDGFTGNAKYVANRVSFGRLFRSATITIREHEREKRIRKRAEDLTGFDPKDVKDTEKQQNESSHSGGSASHGHREDDEERQGKHKLCQKTEIPAGRPSLAQVQDRLDDLPIGTELHLLLVKEIQTVSQHLREPEPRRYTFEEWAWYLALIGEDERDPLNHRKVLPKAKHRRTRRHKHKHHNRHRDKAEQGRDPPQDDVAETIRAPRPSMQLAAPIPVQLPDTDAHLKWSWVGNRSPLMGGQEESEWILDKLMERLEESLWETKIDEDDANSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUN2</accession>
    <name>A0A7D5UUN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA delta isomerase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ECI3</name>
        <name evidence="1" type="ORF">G6M90_00g032020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986333.1">
        <property type="nucleotide sequence ID" value="XM_066130096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUN2"/>
    <dbReference type="GeneID" id="26243938"/>
    <dbReference type="KEGG" id="mbrn:26243938"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="273" mass="30484" checksum="F242D3169203CE56" modified="2021-02-10" version="1">MSLFTVPIPPCGAHPGGSITATQPQPQVYLLTFVSPPDNRLTTAFCRALLQALDILEFGGYTPGVVVTTSGIPKFYSNGLDLEHAINTDGFWQLFFDLWTRLLTYPMPTVALLNGHTFAGGLMLAQAHDYRLAPDPKGFLCLNEVLFGAPLKPPMAAIFRHRLAPQAYRTVALEGRRFTGQQAVEYGLADATAASLDDALRFIAERQLTEKAKAGVYGVIKTELHKDLLKELRKEGVDREEARFNEDQRLDGERKEFGKVWFEQWNKENKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUS1</accession>
    <name>A0A7D5UUS1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g046110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544739.1">
        <property type="nucleotide sequence ID" value="XM_014689253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUS1"/>
    <dbReference type="GeneID" id="26242080"/>
    <dbReference type="KEGG" id="mbrn:26242080"/>
    <dbReference type="OrthoDB" id="10522751at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029001274" evidence="2">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="116" mass="11173" checksum="D0E92DF75FC68CDB" modified="2021-02-10" version="1">MKVYKQLLLVFALGATAQQASPLPTGQPPLHMFPPVIHTTEPVPSGASLPTTPGTKVTGASSGSGSSATDTTAASASGSGSAATTSGTRTSTGSAAPTAQVNIAPILGIAAAVMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUY4</accession>
    <name>A0A7D5UUY4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986146.1">
        <property type="nucleotide sequence ID" value="XM_066130061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUY4"/>
    <dbReference type="GeneID" id="90967577"/>
    <dbReference type="KEGG" id="mbrn:90967577"/>
    <dbReference type="OrthoDB" id="5068804at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="214" mass="23679" checksum="F352E4E640ABEEA8" modified="2021-02-10" version="1">MRSTTEVEYRSKEFEANPQCLIKEKQNVVTASQKEESVNEEIGVQEGLEIYTQLVHHINEMHLALSNLQVRGPASAFLLLQTLAGALSKAIITQLYDKEQDDKVKKPEKQKTRPCGTSEGSDIESRSLLSDGCNQCVSRQDITYNECAHVGAAECRVHVIKDISMGHDGKQIFVATLGEVFDVSGVSAENRATQLIGSMSDTALQEYFRAQSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV01</accession>
    <name>A0A7D5UV01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g046280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544755.1">
        <property type="nucleotide sequence ID" value="XM_014689269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV01"/>
    <dbReference type="GeneID" id="26242096"/>
    <dbReference type="KEGG" id="mbrn:26242096"/>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="61571" checksum="4A822C5E72962C1E" modified="2021-02-10" version="1">MGSEFGITPDTKPEVRLDGVGIFWIVFAVTWTVILISGMAFLWTKRDMPILRIRGLGLSFTAIAFLHCYWVAVTTGYVYGPLMPEVAEFWIMSIWFPFGIALFHASNSRFLYVANAQKQYVKKTGDLGWDGQRPRIRKTLVARWKMLPYTQRVLIFVGLGMVAHLSLTIFMFLISRKFHSGWGISGTEVTGTAMEQKAEQGRGWEWWPSIFWQLFWAWIVAPVILWRSRNLRDTQGWRTQTIACCLSGLHASPMWLIALYVPGMAPVNNYFIPPQWIAIAMMMLEIFTVFIPVWEVRRQQSLCQETLDSIARWESRQKSVQHSGKSLHSGTSSSSWMGRTKAGSVSTTGGSILTMDALEHTLAKNPEPLQEFSALRDFSGENIAFLTRVREWRAQYIVNPSLREPVRDEKDSEKTLTLSRECFESALRIYIDFISSNSAEFQVNLSSHDFKNLKAIFEGAARVVCGECSTPDPATPFADVPKPQSESGETARYWGDIPEAFNEGVFDDSEMSIKYLVLTNTWPKFIRERRSFDGASSAEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVP5</accession>
    <name>A0A7D5UVP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g050210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545128.1">
        <property type="nucleotide sequence ID" value="XM_014689642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVP5"/>
    <dbReference type="GeneID" id="26242469"/>
    <dbReference type="KEGG" id="mbrn:26242469"/>
    <dbReference type="OrthoDB" id="4959284at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="632" mass="72390" checksum="F340C4E460B51B2B" modified="2021-02-10" version="1">MVRRSRRRPGNFRRSVNRPSRPRNQYFPRYHPSDEPDRQYHDRPREETLTSATNEPNHDHGTMSSFRNNAKPIEHGPSSSMQHHPPPLGHLRRDIDIKHLVELLCDRMYWYMQRDKQDKNLKKMQTELERCRAPESSNHREVLKLQIDQWKREKTKSCERLGGTDGKLLTHLAAFINRQNEELLKTTHGNALRSEDVDARLNALQKALDEKFSACLEEAFTQIVNENQLQLRKETEGLKIGLEQERQKSARLQMHIEELEQRLGSWDKRLPNFTEETMEDRLRSDGRLTELERKLNQLSKKMDDLASNMMTSQALSRELGRFDTIVSAFENSKGVEDGSRRTEDDDPGMKTRQRLETVTDEMHIMKLSLQCESVDGAPQSIAGLHRRLDSCMEIVHTNSKEQMSTSEAVKAIEDALKLKLSAQTDDGGQHAQAKLASRHKTEIEEIFDQKFQPLSASLGDKLKGMMQEKLTKVAHDLGSFVDKERIARESAAAKADQSLAEVSALRRGIDGLRNSISTSVDKLDQKIGEQRKLGTSWNERLSSLDSGLQRISKEAETNFQKLELQLQTVSAWQGNFTTKDLYRDIIKDITNNLPPGPLQKISSLTTRLETIEAHLNNSNGDGVSKRRKAAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ7</accession>
    <name>A0A7D5UVZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP_1</name>
        <name evidence="6" type="ORF">G6M90_00g031870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986430.1">
        <property type="nucleotide sequence ID" value="XM_066130095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ7"/>
    <dbReference type="GeneID" id="26243923"/>
    <dbReference type="KEGG" id="mbrn:26243923"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028848176" evidence="4">
        <location>
            <begin position="16"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="107"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="361" mass="39173" checksum="13986C4907E8FC72" modified="2021-02-10" version="1">MLLKTVLGFVATAAAQLTAIDHTKALVTRAGTERISNRDFSAIRFYSQHAAAAYCNFNAAPGTRITCQNNACPLVMRNQPVVVASAIGDALGVGAYVAVDYVRREIVLSFRGSNNIRNFIADLAFAWSDCNLTQGCKLHTGFAQAWYDISDAITKAVRSARSSNPNFRVVATGHSLGAAVATLSAAYLRRDGLAVDLYTYGSPRVGNKNFATWFLTQRGVQWRVTNGDDPIPRLPPLVFGYNHISPELWRPGGDVQTVWQPSTTAICKGVDNTDCNGSGLSPDPWAHRNYFGSVDACAGSSLTLRDARGLPEDLINRLTDWSRQDRQLSGSLGHHGDVEFLLKPLDESPASAPGKHEYTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW01</accession>
    <name>A0A7D5UW01_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UBC6</name>
        <name evidence="4" type="ORF">G6M90_00g040620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547410.1">
        <property type="nucleotide sequence ID" value="XM_014691924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW01"/>
    <dbReference type="GeneID" id="26239973"/>
    <dbReference type="KEGG" id="mbrn:26239973"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="29090" checksum="CEC9F4AB1F7FF8B6" modified="2021-02-10" version="1">MASKAAHKRLTREYKTISENPPPYITAHPSESNILEWHYIITGPEDTPYHGGQYWGTLIFPPNYPFAPPAIRMHTPSGRFQPSTRLCLSISDFHPKSFNPAWEVSTILIGLLSFMTSDEMTTGSVSTTQTEKKYLSSRTRWWNSTGGGSHAKNPALKGNVKAGDGGAKFRAEWPEVDLDNWEWMRKNKVDSTTGNRLDGEGGSSCGPQLGIAGTSGHQAQAVVDAVVQQRDAGRGWIYRNKLLVAGAAIFIYVLIARLVNGEGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW21</accession>
    <name>A0A7D5UW21_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g048740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986609.1">
        <property type="nucleotide sequence ID" value="XM_066130445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW21"/>
    <dbReference type="GeneID" id="90967740"/>
    <dbReference type="KEGG" id="mbrn:90967740"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="160" mass="17919" checksum="2D6C73C2CA10D0A3" modified="2021-02-10" version="1">MSAHTLPSAHLSNALPGFHFPSCLEKVILLNSRPLLNTNNQVNNTLWILNCRYREGVNDDFHEAAVKQLWSDDKPHQTCRNSNRDALDREVFPSYRLLIFGLSQESHVSIISFTHGMILFHSSTPPSQDSVCSPHGFPIIATSVLMFLVSISPPDPIRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWS5</accession>
    <name>A0A7D5UWS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-dimethylallyltryptophan N-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.261</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">imqF</name>
        <name evidence="11" type="ORF">G6M90_00g039190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58209"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:67248"/>
            <dbReference type="EC" id="2.1.1.261"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.261" evidence="8"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547274.1">
        <property type="nucleotide sequence ID" value="XM_014691788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWS5"/>
    <dbReference type="GeneID" id="26239837"/>
    <dbReference type="KEGG" id="mbrn:26239837"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="10">
        <location>
            <begin position="35"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="40876" checksum="96DFF15EE2B1CBF7" modified="2021-02-10" version="1">MENGTVLDIGGSSLTTDIGARLRDVLKSKDEGGKKPVLPDEYLYNDLGLELWRRFISQHEFYQTRDEVAMFQANGKDIAKQFARDSKKLFLLDIGAGDTGKVHHLLVELEKHAQVPITYCALDISKASLETNVEKLARQHSGPGSMVNILGLWGTFQHGQKFAREKNFDGRMIYLSLGSVLCNDEWDNAVDHLKAWKDVMRPDDLMLIGMDGHTAKDEDQKKKLWDSYHKREDLLKPFFDNGYDGMNRSIGEQIFNDKNFEYHAELEDEPTTRHRNWITAKKDIWCEATNSMIEAGQEFDWFDAHRYGPEKVKGMCSQVGLEVMKVWQAKDSHFYQYLIQSISIPVLMDSDSGVSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX02</accession>
    <name>A0A7D5UX02_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g042150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547554.1">
        <property type="nucleotide sequence ID" value="XM_014692068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX02"/>
    <dbReference type="GeneID" id="26240117"/>
    <dbReference type="KEGG" id="mbrn:26240117"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="232"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="445" mass="50609" checksum="6750DA79A1897D6D" modified="2021-02-10" version="1">MPHEIAPGHLGNLTAEQEDKLRQLWEAVFKVCGVSDSSDASPAPKKDEKPGADAETTKKKRGFSFFRSAPQSAHASSNGNNATDSADDDKYGLTKQYQEILANQKPEEIRETMWAMMKHDHPDALLLRFLRARKWDVEKALIMLISAMNWRHTKMKVDQDIMKNGEAGAAADEKNGDEKAKKLGQDFLKQSRMGKSFLHGTDKEGRPICVVRVCLHKAGDQSPESLERYTNIIFDMTGFTLANMDYHPVKFMIQCFEANYPESLGVVLVHNAPWLFQGIWRVIRGWLDPVVAAKVHFTNYRTGLEEFIHPGQLIKDLEGDEDWTYAYEEPTEGENDLMKDTTTRDRLLKEREKLYAQYEAATRRWTKHASGEEAEGIKAERDDIAAKLRDGYWQLDPYVRARSLYDRQGVIRSDGDVNWYRNTDSKSAPSNEIKSGKETAANAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY35</accession>
    <name>A0A7D5UY35_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthetase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NRPS1_1</name>
        <name evidence="8" type="ORF">G6M90_00g056040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544197.1">
        <property type="nucleotide sequence ID" value="XM_014688711.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26242609"/>
    <dbReference type="KEGG" id="mbrn:26242609"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="647"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1734"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2992"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="3522" mass="387911" checksum="F95370B68BCE1480" modified="2021-02-10" version="1">MPLQNGTASKEACFLANGSNGTKTTRIPSTTASNGSPATVTQTVKIDHDREPHSNGELMKPASGSAAAPQHLEQMWGWNSMAPKSVERCVHDLISERVRAQPDAPAVCAWDGELTYSELDGLATKLASRLRRLGVRPDILVPLCFEKSMWTTVAVLGVIKAGGAFVLLDPSLPEQRLQVIVQQLQAKVIVSSPSNGEVSSRLTQRAVVINWEFFTSTELDNIDDDVPQTYPANPASLLYAVFTSGSTGIPKGVLITNKNAASALYHQAECMGMNENARIFDFASYSFDVSVSNVLSALATGGCLCVPSDEDRKDNLEQSIASLEANILDITPSMAQVLSPDRLPSVNTVIFGGEALHPTDIKRWWGRVNIIHIYGPCECTPTSTINYNMAGPDEAVHMGKGVGLVTWIVDPEDHETLLAPGCTGELLLEGPLVGRGYLNDDAKTAASFIEDPEWLLRGTATKPGRRGMLYKTGDLVQYTSNGCLKFVGRKQAAQVKIRGQRLELGEIEHTLRNHARVDEAVAALQHEEGQESRIVSFVTVRDVDGIDSLTDNGDGRKAHCDGEYTSMMDHRGRTEQFLNNGKSQKRSKQEIQNELFGMLKAQLPLYMVPQVIEVLDRMPLNRNGKIDRLALVKGLESKTSVRVPVWQPVLEVQRQMLQVWAQVLNIDPSTIGADASFFHIGGSSISAMKVVAVAREIGMKLSVADIFRYPVLHDLVDQSLHESPDEKPDQEIGPFTLLSNEASPSTLLQEICIQYDLGQIDGTTGNTFIQDAYPCTPLQEGLMSLTSMSPGSYIGQNVLEISPDASIEKLCAAWEQVVRRFPILRTRLVHHDRVGLVQIVMDEPINWIEADSLEEYIKSDIERPMDLGRPLTRFALIKDTIGTPKWFVLTIHHALYDGWSMPLILDAVKKAYRGKEFRQGPPFQAFVQYVKNQDSKMMRAYWVDALDDCQCAPFPSLPPHIEKPSTDKSAQYSFPKPQSNRLGITPPIMIRAAWALLVGKMTSTEDVVFGVTLFGRNASLPGIEMIAGPTFATVPVRIKWNSNDMAVEYLKAAQQQATGMIPYEQFGLHNLAELGSGTRQACRFQTLVVIQPEEASDSSSELGTWKGDFGQGDRIDSYGLVLIMQLGRETVSVSASFDSRMIEPWRVDKLLSRLGHVVSQLNQANPELLLSDVETMTPEDLEQMWNWNHKVPLAAEKCVHELFEQTAQAQPEASAVCAWDGEWTYSELDEASSRIAHYLVILGVRLEQIVPLCFEKSRWTPVAMLAVMKAGGASVALDSTQPEEHLRTIVQQTEPALMLSSWANRELASRVTRQHVVVVDDSLLARLKSVSGTCQLPVVTPSNKLYVAFTSGSTGVPKGAVITHRNFSSAIQHVRNSSSGSVEPTARVYDFASYAFDISWFNNLQSLTNGACLCIPSEADRRNDLAGSIHRLQATFAILTPSTANILPLETIRSLRTLMLAGEALPSEYAKRWVGLTRLTNGYGPCECTPITTIAAIEGGSVVASSIGRGVGVNTWVVQASDHNRLVPIGDVGELMLEGPLVGCGYLGDAKQTAAAFIQDPAWLCHGAPGYLGRQGRLYKTGDLVRYDSDGSLVFVGRKDAKQVKIRGQRVELGDVEHHVRVSIPAARQVAAEVILPADTNGQGRPTLAAFLVVDDQVAVSPDVQVMSVSAEVDHELTRRLPGYMVPTVYFSLKELPTNSSGKIDRRRLRELGAGFTLQQLAQLRSASVSNKRAPANETEHTLQKVWARVLGIDADKIGCDDSFFRLGGDSITAMQASAASRGLGLDISTADIMRSKTISSIAAAASLSKHHAPGVGKVDLRNDDGQPFELSPIQQLYVATQSHPNQCFDQNFFLKLRQPISFAALSKATETIVMRHPMLRARFILTSNGVWKQRILDDASQSLHLSEIDGAASVTSSKASEIRQCRERLNIETGPILAAVLFSDPDCQSLFITVHHLVIDLVSWRILLEELEGLLSGRQLCASPTISFQRWCSLQAQYALKNLQEEIKLEVKVKPPLLSYWGLEADGNLQGAIVSKEFIIDEEATSAILGACNEAFGTRPVELIIAALIYSFSTVFTDRALPSVFSEGHGREPWDDGIDLSRVIGWFTTISPAFVPERELLDLVDTIRLTKDSVRRLSKNGWSYFTSKSAQEITAATHATDFPVEVLLNFAGSYQQLERNDSIFESTTMVENCHPESWSKLRRFALFEFNAHVDKGRLTVSLEYPESTRHGDLIEHWVVSYKAALTNLDALLGSRSPEWTLSDFPLAFTSYADMDEFRSVTLSQLGLQNAQDIEDIFPCTGLQEGLLFAQFKSLDNYRVVLDFEITATETPGDHVDLLRIERAWQAVVRRHPLLRSILVDMVPGSSRTMHVVLKDPKPSISFDQSASEASIDRGLSGGQTRVKYEKYALKHHLSVSSIDEKHVRICFELNHVILDGHSTGVMLHDFWQAYSGTLSADAPSYGDFIRYVEKQPRGSHRDFWVKYLEGVKPCFFPPSKSATGESKDMTVSVPGLEASKVHEFCAKWEVTTASVIQTAWALVLYHFTGCANPCFGNLASCRDVPVDRLGDMFGPVIAMIPYRVRLDGGHSVVETLREAQKDYVDSLPHQTFSLMEIHEALEVGSSGLFNSILSFQRVGEQPDASVDGHTIRERFAHDPVEYPISLSVGDSDTDLSIDINFKGGFIPSTEADRVAKAMGAAVSSLISEPHKKISNESLLTRDDLELIWSWNSDVPTEEGSLAQKQSTLRPEAVTVCAKKAVTTAKGAGLVTWVVDPKNHDSLLPPGCVGELLLEGPLVGCSHLGNTVKSDAAFVKDPKWLLMGVPGKRKGRHGRLYKTGDLVRYNMDGSLIFVGRKEDTQATIHGRTIELEEVEYWAQNHMSGVGQVVAEVIKPQGEDLPSNSLLAMFVHLKDDIINGNKPGSPIKLLPIPADAEGRLAEHLPAYMMPSLLFSVSELPKTMTGNIDRKRLREMAAQFSIEQLETVRSSGQRTSRQPTSEAEQVMQNIWAKVLNASIDMIGLDDNFFHLGGDSISSMRLVSEARKVHINITVADVFHRKTLAELVDGQHVNGVESGPELDEVVLVDSPTKETLSREIVSLCPDIRGEDIADILPATSVQERCFVKGIYPVMCINQDNTVDDALCGRFANYVYIDLPKNTDVSLLERACTRTLGEFPILRACFLRLQGRFWQVVLQNIQHPFRVHDVSENLDVALDNFCVSDAHKVSATQPPVALVLLRHKTQGERLIIRISHAQYDGVCLPTIIESFINGPGTAPPPPSFSSFLSHASLRRSKSIEYWKRLLQGLQHPGALRKHLLAQTDIHKSQPEAIYIRAETSLPRLPGNMTPATLASAAWALLLSRLTGQGDVVYGHLVAGRNSEIGGIDKTVGCCLNFIPVRVTFPSTQTLTELLFAVQEQFLAVGEADSLGYKEIIENCTDWAQGSTFESTIQHQNIDENPQIQSAAGVSRVQFFQNPHLVPMSIHMVSETRGDKLFLELNSNTHIMSLEAAEAMVNGLISIVDEFKTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY58</accession>
    <name>A0A7D5UY58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mur ligase central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g078650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545243.1">
        <property type="nucleotide sequence ID" value="XM_014689757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY58"/>
    <dbReference type="GeneID" id="26241276"/>
    <dbReference type="KEGG" id="mbrn:26241276"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="8">
        <location>
            <begin position="53"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="615" mass="68554" checksum="2D1132E3B318B25C" modified="2021-02-10" version="1">MPAARDIQRALARIRAVMPAQKQSAMANRNIKLGLERISRVVPEEQKWIGVHVGGTNGKGSICALLAGMFKLSGISHGTYISPALPERHNAITINGLYINKRMYDMELQHVEEAYKRVSSGWTFAAGEDPGDLTPFELETAAAFRVFNKMNVQYGIVEVGMGGATDATNAMKDKAVTVISKIDLDHQEYLGNTIEEIAKVKAGIMRPGVPCIVDHTNPSSVMDVLRDHARTVGTQVSLSSKALPFIESLDRDRFKLQDYEQQNLLCATLAFRNLFPHLHIDPNKLLALKPQLPGRMEQVSVAGLTDGTRQKSVLVDGAHNMLGVEALAKYVDGSLRKTSEPVTWVIGLSSSKSKPFSKIIETLIRPEDNLAIVEYAQGPNDPPPAPADLGRGVATQIIQDESRIYDGEPDIGNGVQWACSKADDGPVVVTGSLYMIREFYKMEGVEPSRKIKTRRPGRSQLWRYIQLSKERPLTSEEAREFKQARRHWYLSPMNSSVFRDVRNGGNPVSPSTPESIQKHQRDAAHHKSQADGYRSAIRSAKKDMDSNEDGDGELSKVLESLEKRRDEHLLAYNSAMFKVRGHAVDSEKKYMSFEDIFRQPDKRRSRIAALLRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYG1</accession>
    <name>A0A7D5UYG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g065580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540216.2">
        <property type="nucleotide sequence ID" value="XM_014684730.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYG1"/>
    <dbReference type="GeneID" id="26247025"/>
    <dbReference type="KEGG" id="mbrn:26247025"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="114" mass="12994" checksum="D3471F4527FF9FD8" modified="2021-02-10" version="1">MSSEPREMLLCTTCETVLGHERDIESRNFTGKHGPAILITYVYNITMARPIRIFMSTGWYIIRVVSCAGCKKEIGWIYLKVQQRSQLYKLGKFVLELARLEMIIPPAPPTGVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ67</accession>
    <name>A0A7D5UZ67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g075680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545531.1">
        <property type="nucleotide sequence ID" value="XM_014690045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ67"/>
    <dbReference type="GeneID" id="26241564"/>
    <dbReference type="KEGG" id="mbrn:26241564"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="322"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="574"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="610" mass="63923" checksum="7801F2DFA1962C2F" modified="2021-02-10" version="1">MASPSITLNRILAAAPSTTRGQPTQLSADSKGQRIAYASGKSIFVRSIDNPAESKEYTGHTAATTVARFSPSGFKVASGDASGTLRVWEPENTDKTIGEYHIISGRLNDVAWDGESQRVIAVGDGKEQFGRCITADSGNSVGEIIGHSKTVNAVAMKPQRPFRAATVGDDGNMVFYHGAPYKFNEKSALHKGFVFGASYSPDGAALATVGADKRIQLYDGKTGEPIKQIGQGEHTGSIFAVSWSEDGKKFATASADQTIKLWEVDSGSVIQTWKFGDGLSIRDQQMGVVIPHGRTDGLIISVNLEGELIYLNEGKNEPVKILQGHQKSITALTGSSDGKGSALWTGSFDGRVCHWNIKTGTASVVDGGSHTNQVVQITGVAGKIYTAGWDDTVKIADESAGTFVGEPISLAAQPKGVSASDGVLYVATVSSIAAYSGGKLLKETAVSYTPTSIAASGSLVAVGADKNSVKVYKASSGGSLEELQTLTNPTGTISALAFSKDGSHLGAGNSVGKIYAYNTATWEVASDRWSAHTARVTCIAWDDSGAYAASGSLDTNVFVWCLEKRNQGKRIKAANAHKDGVNGISWIEGGQIASAGGDANVKIWDVKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZL5</accession>
    <name>A0A7D5UZL5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g070160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987111.1">
        <property type="nucleotide sequence ID" value="XM_066130928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZL5"/>
    <dbReference type="GeneID" id="90967926"/>
    <dbReference type="KEGG" id="mbrn:90967926"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="122" mass="13899" checksum="9BD7D15489C63BD3" modified="2021-02-10" version="1">MTPPCHSFPASELPARIQLDVHGRRRKPAPGANSKIDLSACELLQMLQYKCEVQRPLSRESAVQCFPVDRLFRRCADRKGSFMVETTAWEGRNAQLEQKDGDGEGKKRPFQWSGSWHDDVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZM5</accession>
    <name>A0A7D5UZM5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g076030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545497.1">
        <property type="nucleotide sequence ID" value="XM_014690011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZM5"/>
    <dbReference type="GeneID" id="26241530"/>
    <dbReference type="KEGG" id="mbrn:26241530"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="710" mass="79687" checksum="7C89E9BA42ADFB7E" modified="2021-02-10" version="1">MSYITVAAATLTSVPLDFKGNLARILESIKLAKEQGAKLRTGPELEVPGYGCLDHHLEGDTFLHSWEVVAQILNDPMIKDMLIDVGMGVRHRNVRYNCRVLLTYQHIYMIRPKMSLANDGLYREARHFTAWSKPRTTETYYLEKVVRDITGQRSVPIGDVVLSTMDTSVGCETCEELFTPSNPSTYMGLNGVEVILNSSASHAELRKLNTRLNLIQNCTRKLGGLYVYANATGVDGEARMMFDGSSMILCNGAVLGQSPQFSLKEVEVLTATIDLETIRSHRSSISRNVQGAAQPDYPRVECDLYLSRPADEVFISDTLHLSREIQLNIPDPMQEIYMAEAVYLWQYLTRSNLGGFFIALSGGLDSASVSLFVYGMAKVVLQSVKSGDERTLSELRRITGEKDLVPETPQDIVSRLLHTCYMGTVNSGEHTRSRAKRLAARIGAFHSDVNIDETVSAHEAIIKQAMNFEPKFQVEGGSVAENLAKQNIQARNRMIVAYELAQLSTTARKLPRAGTSLLVLSSGNVDEALRGYLTKYDCSSGDIAPLGSISKSDAKSFLAWCRDTWDMPIITEFLEARPSAELLPLSAGEQDDESESEMGFTYDELSTFGILRKVEKLGPWSCYLRLLVEWQDRPGYGPREVATKVLRFFRFYSIHRNKSTILTPSLHLSAYNPDDNRHDLRPFLYVVSWPWQFEKIQKHAEELAEKLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZS3</accession>
    <name>A0A7D5UZS3_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">CTP-dependent diacylglycerol kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DGK1</name>
        <name evidence="3" type="ORF">G6M90_00g071690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690404.1"/>
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    <dbReference type="OrthoDB" id="5673at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
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            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
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        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="43370" checksum="84CAB385DB518836" modified="2021-02-10" version="1">MSLRRKAASSVPETPRIISPSPDPPEHDAGYSAPTTRSAARRRMASSQHSQDEHPQQDDVDDEVPGLRRSRTRSRSPIDSRTMARMTPSNSSLAMKPLSKEPSEKVVTNGKISASNGHLAPPQPATPSGWSWRDFSRSPSPLGLIPIHRHWRTFVHKHEVPRKALHVSIGFFVVWLYTTGTQTQAVPPYLMAGLIPIATTDWLRHRYAAVNRLYVRLLGALMRESEYSGYNGVIFYLLGAWAVLYFLPKDVGVMSVLLLSWCDTAASTFGRLWGRHTPRIRRGKSLAGSFAAFLVGVATSFFFYGWLVPVIGPMPGDENFMFKGTLSLPAAVASALGVSRAAATVSGTLALSIMGLWSGFVASASEVIDIFGWDDNFTIPVLSGIGIWGFLRLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V002</accession>
    <name>A0A7D5V002_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g079340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987235.1">
        <property type="nucleotide sequence ID" value="XM_066131126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V002"/>
    <dbReference type="GeneID" id="90968024"/>
    <dbReference type="KEGG" id="mbrn:90968024"/>
    <dbReference type="OrthoDB" id="5242786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="581" mass="63264" checksum="E7F6992EF842BF4B" modified="2021-02-10" version="1">MRRFKGAKGDSIAPATDKERQDDDSAAAATTNSRQSSSSIPSNRLSRTSTSDSIPRRRASEYEQSPISNRRASSNASSTYYPAPSLYPAPTKPLPALPPKATNSASRSIGRPPSERSVSIASSGRSSHYSDRSGSVAAGPSGSFSFKSPTSTQYTAPSEFQHGDQHSQLSSLELCFRNMIVSQDKRINNSVYYLDVSSTSSTLATKHGNNIVKIWSLETGDIGSVIKFSSYTEAQSRSRDYLIRSHAILSETCKLIAIATRFGRSIEIWNWEKKKCLQTLDNADRWSVGKMEVYDHGWGRLATYRGETGVIDLFAATREKKPFVKMRCINLAEANLPFIPQYPELALSPTSPLLVAAAGPRPPRRGHPPPDKETLLVAWETHDNGLVGSKPYRVARPWQHREIDTAIPSDLTTYGSVVVSIWIPATFRAVPAPAPRGGAGYSYNLTPVKVPSRHVLVWDLAANSTRTFAIPNCTSCISPDCRYVAYCHASGAAIGARGTLAVIDVMSSQEVWCWPDRNATAMDSGPRPGLKQFEDLARVTELAFSADSKSLVVGDGEGRVGVYDIRGKEDSEGLGNLGMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1G6</accession>
    <name>A0A7D5V1G6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ank2_2</name>
        <name evidence="4" type="ORF">G6M90_00g079350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987079.1">
        <property type="nucleotide sequence ID" value="XM_066131127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1G6"/>
    <dbReference type="GeneID" id="90968025"/>
    <dbReference type="KEGG" id="mbrn:90968025"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051631">
        <property type="entry name" value="Ankyrin-KH/SAM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206">
        <property type="entry name" value="MASK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23206:SF7">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
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        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="442"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="604" mass="64085" checksum="D45680ECE9845775" modified="2021-02-10" version="1">MSLSDLANELLVAVAQFLDAERDIDAFAKSNKRLYSLLIAHLYRYNAHNSSASALVWAAKTGRVETLRRAVSTGVKVHEFPLLPIASDKGHLNFANLLLRTPGVDVNVKDEDGWTSLAAASRQGHVDLVNLLLAANADLQTNDAGWTPLSVAANDGHLEVVRLLLNKGADVSVPSETGWTPLRSAACNGHFEVAKLLLAHGADVHVTSERMWTPLHSAANSGHADILELLIDYGANTAAATADGWTPLALAADKGMVEAVNILVAKGADVALPCGNGWTSMTLASDSGHVPVVQILLEKGASVDAPCINGWTPLTLASGAGSVAMVELLLDHGADIKATNESGSSSLLIASDRGHCAVVESLLARGADVLSTSRRGLTALHTASENGHVEVAELLLAQGADIAVGNFSGWNAVHIAVQNKHPKLVELFLGTPGLDVDLKDNYGRTPLYHAAMVGNADMVDLFLARGASPTMSDSYGSKPIFTAVRNGHEAVARRLLAVSPYPSEQLDGFGHSLLWWARRSGRPGLLQLVRQHITMHDPGAEMDEEMEPETNPVKFIENACWCKVCTRCTVLGTTSYECTTCDGEVAMIVDGGVVVACLLKARFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1J2</accession>
    <name>A0A7D5V1J2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase ESCO zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g085260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541083.1">
        <property type="nucleotide sequence ID" value="XM_014685597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1J2"/>
    <dbReference type="GeneID" id="26246072"/>
    <dbReference type="KEGG" id="mbrn:26246072"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase ESCO zinc-finger" evidence="2">
        <location>
            <begin position="218"/>
            <end position="255"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="267" mass="29984" checksum="A9A2FA66FC1FB12C" modified="2021-02-10" version="1">MMINSSPEYAITKPGMSHYLSRKRDKPLRTYGRKAASTPEPRGEPPAKRVRVEPQAHINMERKLPAMQNPSSKKEQSDSTLKLEKESPPLPSAEAATRSSILQYFKPVPIDMKKLEHIEKKGDVHRNPEPALSRVVRRRRKARLLRIRATSLPSDESEDAMSLSGRDETDSNASSPDGKRKTLYAREGSVLSQGRRDSTSSDIKPGLGTRSGRSPTVQTTLNISSKAAFAECKVCNIVWNPLYPDDVKYHDKRHKTMVRKAKKADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1M7</accession>
    <name>A0A7D5V1M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g088900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131340.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
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        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000030">
        <property type="entry name" value="DUF618 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="384" mass="41895" checksum="FA8DD6F310010F74" modified="2021-02-10" version="1">MAYNDDSVLARLSSLNESHDSIATAAQWIMFHRRHADRTVQLWMQRLKDSSSTKRLSLVYLANEVVQQSRIRHKEDFVIAFSPIVAEASSIAYKGAPAEIQAKLRRVIDVWKDRSIFEAPIQRAIESRLDELDKARGAPKSGFSGSPFGSSSVPSEFSPLIAAHQKTVKLSGPLQTTISSANQEYDKQMDPNVAVPSAPVYAARLNGLLKTLANAESAVAECVKAREHLVSGLEKLLDESRSALEADKSAAGELLKRKAEIEDKKQQVEVAIMRALGPTESNGQPGEGDTGSPHNELDRPEMEALTPPQMEDEDADEPVEASETANVSSSTEQDSAHSFQSIPVSTNGSNKRRRVDDSEDFPDLGGDDGIEPEVAEMLKDSAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1N8</accession>
    <name>A0A7D5V1N8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">tca-9_0</name>
        <name evidence="14" type="ORF">G6M90_00g072520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545811.1">
        <property type="nucleotide sequence ID" value="XM_014690325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1N8"/>
    <dbReference type="GeneID" id="26241844"/>
    <dbReference type="KEGG" id="mbrn:26241844"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="89"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="364"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="447" mass="48338" checksum="5EC379BA20DD9229" modified="2021-02-10" version="1">MFNIGRSRALASALNASKLQVAPAVRFPGVAQQRRALSIHEYLSADLLRQYGIGVPKGAVAKTAEEAKAVAKEIGTEDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPHEAEMFAQQMIGHKLITKQTGAGGRLCNAVYICERKFARREFYLAILMDRASQSPVIVSSSQGGMDIETVAKESPDAIITTYIDINTGVTDDIARGIATKLGFSEQCVEDAKDTIQKLYKIFLERDSTQIEINPLSETNDHQVLCMDAKFGFDDNADFRQKEVFEWRDTSQEDPDEVRAAKSGLNFIKLDGDIGCLVNGAGLAMATMDIIKLNGGQPANFLDVGGGATPAAIQEAFELITSDPKVTAIFVNIFGGIVRCDHIATGLIKTVENLNLKIPIIARLQGTNVEQAHKIINESGMKIFSIDDLQSAAEKSVQLSKVVKLARDIDVGVEFTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1P0</accession>
    <name>A0A7D5V1P0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HSP31</name>
        <name evidence="7" type="ORF">G6M90_00g080830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539435.1">
        <property type="nucleotide sequence ID" value="XM_014683949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1P0"/>
    <dbReference type="GeneID" id="26247754"/>
    <dbReference type="KEGG" id="mbrn:26247754"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="28"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26068" checksum="CE8B5BD244641525" modified="2021-02-10" version="1">MSRRILFVFTSNDRLVNTTVKTGWYLPEAAHPYYGLKTAGFEINFVSELGGRPPLDESSISATKNDAVCQRFLNDAQVQKMLDEAPPLSSIKLPAPEYDAVFYPGGQGPLIGLPQNTQSQNLIRTMFEDGRVVSAICHAPAVFTEVKLRDGKYLVDGRKVTSMSNKEEELWGRVPYVPYLVQSRLKERGGIFIEGSTAWGDHVVVDKDSHGRKLVTGANPASGGSLAREIIKLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2N3</accession>
    <name>A0A7D5V2N3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein transport protein Sec61 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g081720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543408.1">
        <property type="nucleotide sequence ID" value="XM_014687922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2N3"/>
    <dbReference type="GeneID" id="26243585"/>
    <dbReference type="KEGG" id="mbrn:26243585"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7679" checksum="9A39DAEFC50116E7" modified="2021-02-10" version="1">MSDQIQELVETPSQFLKDGVQFMNKCQKPDKKEFAKICQAVGTGFVIMGVVGYVVKLIHIPINQILVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2P7</accession>
    <name>A0A7D5V2P7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="17">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">G6M90_00g100800</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="17"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546269.1">
        <property type="nucleotide sequence ID" value="XM_014690783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240692"/>
    <dbReference type="KEGG" id="mbrn:26240692"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1207"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1241"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1270"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1316"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="221"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="1093"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="14">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="685"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="708"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QLI73155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1411" mass="159817" checksum="AE690EEAC987CE33" modified="2021-02-10" version="1">MAESEYSTTEKRPVQNTHESKLRRHKTPAIRAPSIQQLESKLRDAASKFYQSTVVELILRRKHLSASKDGRHIPLAVEHSEPLIDTRRGHAYISNNVRTSRYTVWNFIPKQLFFQFTRVGNFYFLCVGVPQMIPGLSTTGSYTTILPLLFFILLTVAKEGYDDFRRHRLDKVENANFATVLGREDHYTGKLKPPNLLHRLNPFHIKTTAQPRPGPADEFQGIRWVPTRWSNIKVGDIVRVSRDEPIPADLVLLHSDGENGLTYIDTMALDGETNLKTKQVCHALEGCGTIQGISTSQAEFVVEDPNPELFNFDGRVTVNGKAVPLTLNDVIYRGSVMRNTTSATGIVINTGEECKVRMNSNQHPRAKKPALEKVVNMVVITLATYVVILSVGVSMGYVKWKSDYEQHAWYLDMATVPFYQIIIAFIIMFNNVVPLALYISLEIVKIGQLLLLNSDIEMYHDESDTPARCNTNTILENLGQVGYIFSDKTGTLTDNIMKFRKLSVAGTVWLHEDLIDDEDIQKPPAHSGEMSYSDRKGSVQKSGPIILEEQINDLEMPMSPSRASFGGRRSSSQWRSTGRPDHIQPDVNTSDLVDYLRIRPHSAFARKAKEYLLAVALCHTCLPEVKDGKIDFQASSPDELALVRAAYELGYQVTRRTAKSVTLQVPLPSGGFEKMTFEILDVIEFSSARKRMSIVVRYPDGRISIICKGADSVILPRLKLASLAMQKASEVRKSADLEHEMYRRSQQYEPRNSFGGRPSLTVRRTAGLHRGRSIDQQRSSMKRRQSFEIHKLMRLSDDRPHGGLSAPRGVSLDVSRTKLLSQSNHHQPQSLPEHLGFLEDSTIYDESEVFTKCFKHLDDFATEGLRTLLYAQKFVSDHDYRAWKKRYDDASTSLVNRQDLIEAAADVIEQSFDLVGATAIEDKLQQGVPETIDKLRRANIKIWMLTGDKRETAINIAHSARICRPGSDLYVLDVAKEPLEAQLMALAEELHTGSIHSVVVIDGQTLAAVEKSNTLSKQFFAIMLLVDSVICCRASPAQKALLVRTVRSSLGKFKSNKHSGLTLAIGDGANDLAMIQASHVGIGISGKEGLQAARVADYAIAQFRYLQRLLLVHGRWNYVRTAKFILYTFWKEMFFYLPTAQYQRYNGYTGTSLYQATSLTVFNTLFTSLCTICLGIWEQDLSAETLLAVPELYVYGQRNMGLNAWKYARWMFLAAVEGVIVWYGVWAGYGWISPTARDEGLYALGTLVFTVGVLWINWKLFIFETHYKSTIVMCSFFITTWGWFAWLSFLDGVYAPGPEGPYLIRHTFTRAFGDDAVWWATVFIVLAFLGLLELVGKTIKRNMLVAGVWHWPPWKRHRLNDNVEEWDLQVWQEMEQDPKVRERLRRLANDEETMEDIEAEDVFNVEARMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2U2</accession>
    <name>A0A7D5V2U2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FAN1</name>
        <name evidence="11" type="ORF">G6M90_00g103080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546040.1">
        <property type="nucleotide sequence ID" value="XM_014690554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2U2"/>
    <dbReference type="GeneID" id="26240463"/>
    <dbReference type="KEGG" id="mbrn:26240463"/>
    <dbReference type="OrthoDB" id="4935617at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="722"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="858" mass="98554" checksum="9AB079E000FA2AF1" modified="2021-02-10" version="1">MDAFVTHFYRSDTSDESCRSASHRDSAGERAPKRVKRDEIKNPGPDFPDSEESDHGNESQKKTNWGSHHSEDADTSYLHEATAFENVLPPTQTDADAIEEYEQTRSSQKEADNDGTTANTKSLWIKGRSSIYVDAFNLALDTVLEEESELFDEKEMEVFRRWKVLSYEAQYLYVRLFLRKTAAWHRSSRLGYYSDISEPEEAIAALQAIQKLPTKNSQDTEELVSGFDLERFNLGASFAFADASEDYINSVEEAASLLLLDELRALAKDAKIQGKNKAELVKGLCRMSQQQLGLMALGLSRQNSRDSDVSVSDQESTGSCKNGHLKRQNLNRNEHFLRKMLAILGPCIRLSPLTYKLFERVHLVFYRSTEWTEKSLTTIILAKIARRNFPEYIVCRTSTIFASRLHLLEFEAGIRLEADVDNILESSGVPNEEDLQRIMDIFEMVYPRWKQYVNEEGEKERMVYEMGEGAYLRRFNPAHSYTRIIVKAMWVMGRRKEYAREHGLLEELLDQKLFHLARRGSWYQRKALLEEHYMPTVRDDEGSGDLEQRRKQWKRIAATTCETALQDPDCHLIHHYDLQKRLIKLERKLRIPRRLQHDFGHVRLAEPIEINVEGIQLKRSPSLKPGAQQASTKTVWLDELDTGGECSVEEMCLSHFRSQGWKGYHAEGGAIRTIFAYLFYDILFLYIPNVFQTEYQTCPLDLHTDAFFSARASEINHRLVEIANGQGERFLRQVWDREHERRTSVVGLNWDFDVDDMAQLVRCFEGSALAAICKVMAQEYKHRGGGVPDLILWRANDQSAEGARSTPEAPRGEVMFAEVKSANDRLSDTQRLWIHVLTGAGVTVALCNAIAREVREVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2U3</accession>
    <name>A0A7D5V2U3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g084240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543640.1">
        <property type="nucleotide sequence ID" value="XM_014688154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2U3"/>
    <dbReference type="GeneID" id="26243817"/>
    <dbReference type="KEGG" id="mbrn:26243817"/>
    <dbReference type="OrthoDB" id="5393057at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="6">
        <location>
            <begin position="67"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="7">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52090" checksum="662E3675375D48C1" modified="2021-02-10" version="1">MKSMKGLSMNKMLGSIKKKAGGSSNAPPASAATHAENPEVTAHNSVKAFCESGGNSKTDEVLFLPPIVDAAESSPAAAAECARVIRKFLSKDYSSRPSWQYNAIMLVRILTDNPGETFTRNLDDKFVDTIRALLKNVKDPSVWQILMETLDDFEYAKAHDQNLAPLVLMWQKEKEAAIKKHGNRQPPLPPRPFITNQPPLNRHSQNYFAKAHHNNRLPDPVELSSRLEEARTSAKLLEQVVMNTSPGEMLQNELIKEFADRCLSASRSLQGYMVSENPAPDNETMESLIDTNEQLQTALNQHQRAVLNARKQLGLGTNENSPVVLSDNSDTESHARHNNAETGLMPGGVTTGAIDAGKGKQTQSYHLTPTGNGEAVASSSRQSLKDESTEDPFADPHPAEAKAAGGSSTQPISEFPHEPFHPGFGGPLSSNNVVLNSAGSSSSRSGLAKEQPPHNRHQGVSDDDDIYEAAPKGKSPLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3D1</accession>
    <name>A0A7D5V3D1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CYP8</name>
        <name evidence="20" type="ORF">G6M90_00g088220</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542293.1">
        <property type="nucleotide sequence ID" value="XM_014686807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3D1"/>
    <dbReference type="GeneID" id="26244807"/>
    <dbReference type="KEGG" id="mbrn:26244807"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="335"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="545"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI72731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="587" mass="63959" checksum="2E44553F1C410915" modified="2021-02-10" version="1">MGKGTDKLYITHSEWSSSDAYSASAGAKSSSLSASGAAPFRRLPFNFCAASLQPFKNPVCTSDGTIFDVEVISAWLEKHPNQNPVNGEPLHKKDLIRLNFARNAASDSLGAGLSDGKGDLIDPVTYKIFTDNTHIVAIRHGTYANVFAWETVERMNIKAKLWQDLVDDEPFSRADIITLQDPKNAASRNLEQFKYIKDGEGAQLTKEQEEERNAGGINAGALGSMGDKVLKAKAAVEKARKAREAGGDVNRSSSALTKPSATSTGPSSIIVASQPAINNKKLAANAAAYTTGKAAASFTSTGLTPETSGERALLTDEEFMLKPKRVKTKGYARIETNLGDLTVELHTDTAPRAVWNFIRLAQTGYYKGVAFHRNIPNFMIQGGDPSGTGKGGSSIWGKYFNDEFDGPLTHNSRGILSMANKGKNTNSSQFFITYKATPHLDRKHTIFGLVVDGKDVLSKMEAVQTDGSNRPLNKIFIRDVVVFVDPFEEFQTQRKEQERQEHEQEEIRRKGGTDDDRTTWTGKRIRGDGTIVSAEGKESVGKYLNKGAVSGNGGDEPEAIGSRLEDWQEPARKKMKGSGGFGNFDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3M7</accession>
    <name>A0A7D5V3M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g083690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QLI72132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131233.1"/>
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    <dbReference type="GeneID" id="26243764"/>
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    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7728" evidence="1">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="216" mass="23604" checksum="3B7AD077B4117A4E" modified="2021-02-10" version="1">MSVQDDSSLLPTDQGQCLNIRCKHCPTGDGHIRLEFTVDENRKLLVNGFELFPSHGDGEETPMTANVHDVGGNAKAIHEEAISYELSTATKERDEIEGIELIDVDYKILQVDSVVVQDIPTVHVRLIKLPSDDILIGVLTTSEEEDYDADCGAVQCWAYKLSFGALGSAGDMIPSCCSKSSTQANHTSSEVDWRPSLNWEKTSLQGLQLGAGHVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3R6</accession>
    <name>A0A7D5V3R6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g102740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546074.1">
        <property type="nucleotide sequence ID" value="XM_014690588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3R6"/>
    <dbReference type="GeneID" id="26240497"/>
    <dbReference type="KEGG" id="mbrn:26240497"/>
    <dbReference type="OrthoDB" id="5375558at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="778" mass="82140" checksum="8DBD33A7D8A2BC98" modified="2021-02-10" version="1">MSTDDKSMAQDAGAGVGSDPAPAAPGNAATSGATTTTSSPCPNPDIATPGTAAVASVAATAALASSSAVHSPPSRPISPSQSPSAPAELTISTTPTTTTAATLPSPTAGPAPASSIDSKPAVPTSLSPSELPATLAAAPAPAPAPASPSQQNGRSEAPEADSDMNSYRPVLTAHNGLPVSYSTTTATVSTSSHLAASPPVTSGYASPTGISTVQYPSYPTSTTVSHPSESYRVSPVSSGNTLSLPSMRTIDSLPQQRPGQPQMPHHAMSISMNPSLTSVSSGPTIYPPHHTMSVPSNYGLPSDSVPRYPLPHDPRILGSRGPKKCDETHPTCNNCKKSKRECLGYDPIFRQQPGAQPNSHIQPAPTSQPVASSSVSPSVPAHSSAGIGHLPATTNTYGSQPSMLASSYSTTSPPSTLSSSSVAHTVSSNYNSPASASATPTIKQEPGFDFATPFDPASRHLPPPTGPDIKPYDYKTLTAADSSHHATSKKMKINEIIDSLGPPPPPQQISHTEETFNEITKVYHEMYAGGLSAFLETTWYYFVDNGKMSFPRDANLIEHMATFLKILEAVRANDHSQMAYSGVLETRIVWELACTAYRIPDATNQANRANMPPEGDATEARNRLRVVEALLCGEYLVTNPLAPPLQDPDTQRTRQFDFWYSLAEFVRKQDLPGSHQALKAREDALSRMRHLLDGRENRDVLYSIAVVRELAPYYGPSYGNTPQYADETDPKNRLAVASKFILDEAQVTGGTTNVVRRFSDIASRAFVNPGVNVARRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3S3</accession>
    <name>A0A7D5V3S3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540789.1">
        <property type="nucleotide sequence ID" value="XM_014685303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3S3"/>
    <dbReference type="GeneID" id="26246402"/>
    <dbReference type="KEGG" id="mbrn:26246402"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="446" mass="50333" checksum="60F710E572906EC0" modified="2021-02-10" version="1">MSPYPTVLEALQWPTTTLDAAEAPPGPNTRVLTALEICTWDNWSDFTFDNIMSIFGNHLKKDYLGQREPVAMERDVEVYNEESVDGGLRRFPFPVINSALGSSTEVQENAPYYGYGTRVKANRMKPDWSCTSNLAKKGSGYINLVPGDTKTSAKFNPDMLKSNFEEWKKVVTQLAAYADGHRVRYGFIVTDVSVIVLRFVREGSAPGVGANLAQRSTRNKRPTRDPTPQSSSEAEITSSQSSEDYGRGQDLLTEFKAIPWSTHGRGKLTAKLALFALAMMSLHGDNYIARGYPKMNTWRGGPNGIRHNTSGEFRMKETPGYDMDEPVGEQPKSKEPEGEEFEEEDEEDDKKNDKEDDEDDEEEDQPQISATASIIGDTDHLAPDITRLKVVHNVEFTKRKGVWYYKDCRGKSVPYKEGQFEYDTTLKRYVKSGRRYKYVAQSLPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V472</accession>
    <name>A0A7D5V472_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g113850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539690.1">
        <property type="nucleotide sequence ID" value="XM_014684204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V472"/>
    <dbReference type="GeneID" id="26247521"/>
    <dbReference type="KEGG" id="mbrn:26247521"/>
    <dbReference type="OrthoDB" id="4939821at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028897760" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="137"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="258" mass="28320" checksum="9C0CE6529DEE1102" modified="2021-02-10" version="1">MRSSLLVIVLPLVGATPRGPPGECDTKTAVSKRGWLGHDVLDGNSIQPAHYSTWHWSNFGLCKGDWSNFGLCKWDWFNWWNWLGSGDESCETDDDTPRPQKPTPTKPETPEEPPTQPSPSTTQAPPPGGGNGPEYINRVNKWMDACGLRHLAHDSTLESNAHQTSVEANGNMVHNMLPGTMAQVMAHGDLTANFDRAFVGGWLCEIKTLFKDKNFCDESSLAEGWTYSGTRHAEILSNSRYTKIGCGTAQSIVTCDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4X5</accession>
    <name>A0A7D5V4X5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin alpha re-exporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CSE1</name>
        <name evidence="9" type="ORF">G6M90_00g107560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544086.1">
        <property type="nucleotide sequence ID" value="XM_014688600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4X5"/>
    <dbReference type="GeneID" id="26243473"/>
    <dbReference type="KEGG" id="mbrn:26243473"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="959" mass="107806" checksum="7E93F3DDFBD7A2EE" modified="2021-02-10" version="1">MAADIGQISQFLNATLDPSQHRKAENALKQEATKPQYSLTLLNIVNSDSLPPNTRLAASLAFKNFIRSNYVDEEGNYKISQDEVQIIKERLIGLMISSPPNVQKQLGEAISVIADSDFWRRWDTLTQELVSRFSTTDPKVNVGVLEVAHSIFNRWRPLNRSNELYIEINHVITTFGQPFVQLLVTTDSKIAAHANDKNALKGWFETLDMQIKILHDMSSHDLPPIFEENLASISELLHKYLTYNNPLLETDDDDEASIVDTAKAGICELLELYTIKYDEDFSKYCAPFITSAWNLLSTVGPQTKYDNLVSKSLHFLTAVAGTAEHAAVFNNENVLSQIVEKVILPNVALRESDIEMFEDEPIEFIRRDLEGSDTDSRRRSSTDFLRKLQERFETPVTTAVSKYITHYLDQGKTDWKAKDTAVYLFLSIAAKGAVTAAQGVKTVNPLVNVVEFFEQHIAADLMASEGVEPISKVDAIKYLYTFRSQLSKEQWTLALPPLIQNMNSSNYVVYTYAAIAVERVLFLADDVGNQMFPRTDIEPFAKDLLNHLFKLIERETNAAKLQENEFLMRCVMRILIVIKDGAAPMLDNVLTHLILITNVMKHNPSNPRFYYYHFEAMGALVRYCSGTNTAIFNQKLWEPFNLILTEDVTEFIPYIFQILAQLLESSPADAVSENFKSLLGPLLAAPLWETRGNVPACVRLLSAVIPKASSLVIQNNQLEAVLGIFQKLLAFKKSEVQAFDILDAIVNSFEPSALDKYFGTILQLLYTKLQGSPADSFKIRFARFYHLVSARLEAGYGADFFIKQSDQLDAGAFAQVYPPFVLAETEKLAKPVDRKTAVVSLTKTLCDSQVFGQKFMKGWASSCRILLSLLANPPAVAAGQGDEIITESSVDDIGFGMTYTALNTCRPLARDDFPEVQNVTTWVKQYMVEANRRHGGAIEGFITQRLPPEQQEAIAQYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Z0</accession>
    <name>A0A7D5V4Z0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dpb4</name>
        <name evidence="8" type="ORF">G6M90_00g098780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546469.1">
        <property type="nucleotide sequence ID" value="XM_014690983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Z0"/>
    <dbReference type="GeneID" id="26240892"/>
    <dbReference type="KEGG" id="mbrn:26240892"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="275" mass="29408" checksum="5EF4E64A7975B3BA" modified="2021-02-10" version="1">MPARKSDQPRKSDALVPDDSTLTTAPADESQEAASAPEKTTKDKDKEKDTTTIEDLTLPKSIITRLAKGVLPPNTQIQANAILAMSKSATVFISYLASHANENTVNAGKKTVAPADVFKALDDVEFSFLKGPLEAEFARFSQIQTEKRTNYRQKARAKHDGAGGDDTEMADTTTAADATAASGTAGGAPRAKKARVDPGEVGDDGDEEEDAETEEEAEVHEEEDDDDEQADEEEGEEGEEGAEEENGTGGETQDVLEERAVSEDRDEALDGDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKN3</accession>
    <name>A0A7D5YKN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KCC1</name>
        <name evidence="16" type="ORF">G6M90_00g012760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549247.2">
        <property type="nucleotide sequence ID" value="XM_014693761.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKN3"/>
    <dbReference type="GeneID" id="26238691"/>
    <dbReference type="KEGG" id="mbrn:26238691"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI63800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="382" mass="43534" checksum="C070769DA453C564" modified="2021-02-10" version="1">MSFAGMLNRLHGQPESYDKKSKYKFGRTLGAGTYGVVREADGPSGKVAIKIILKKNVKGNEKMVYDELDMLQRLKHPHIVKFVDWFESRDKFYIVTQLATGGELFDRICDQGKFTELDASQTIKQIMTAVDYLHDNDVVHRDLKPENLLYVTREPDSDLVLADFGIAKTLDSKEETLKTMAGSFGYAAPEVMEQKGHGKPVDMWSMGVITYTLLCGYSPFRSENLRDLLRECTAAPVPFHERYWKDVSPDAKDFIMGLIVPEPEKRWTSKEALGHIWLSGKNATDHNLLPELEAYRRRARLRRVIEIVKLQNRIAKLKEHEEDPSESDMGDAQGASDNHKGDGSRLHALGLFALREAKQKQESLQVEEELEKESRRRSFSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMS0</accession>
    <name>A0A7D5YMS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-labile enterotoxin, A chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g028900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541277.1">
        <property type="nucleotide sequence ID" value="XM_014685791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMS0"/>
    <dbReference type="GeneID" id="26245912"/>
    <dbReference type="KEGG" id="mbrn:26245912"/>
    <dbReference type="OrthoDB" id="4917004at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028941903" description="Heat-labile enterotoxin, A chain" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1082" mass="120446" checksum="EEAC282C5CD8D167" modified="2021-02-10" version="1">MRFTHGLALLGLAVMAAAYSEVGIYERFYFYYAYKLDAMTVGEKKIATGCGANCNFDEFINFVEENKGANLRKVSTEHFPDIERTAELYANSGAATQVREGRVFNGVGNYGELFEKVRTRLEGLQHKTNYEYDKLSGEELATKVQEVKTKLMESLKQVWQGRVRASLSSFKPYEGFKIVETADGKAVDFKATLEAKENKGAITEEHLKKLWDEHVENFKGADAVKEFKPLKDWHPAIVEENGIISMRSSLEGAVESGWIPKDSKWLQRNWKKSYDIGHSRNVDSVGDTYKALETKLCPGAPSRRDFGLLRKRQALLCIRAAEIEKTMDIKAGDVDNGGKPPGEKPPNPGEEGKPPGEKNIPASEEQVKRANSVSENSFEKSAEKRLGKVPKSFEEKYGTNSYKELRTKALEYKPLEPNSPKIRSGGTGLSKVGKALGAVGGVLYVKGIIDAFRDHVSPLHFFAAVTSIVPFLGCAVETGASVEDKVPAGFIVAEGVLCNVADALLLTPFWPVGIALHLVNAVVKFFRPPPTPPTVLELAEKRDAVWAHALEDIYRYTYSAYETQQKSSFAFKTENALFFDSLNVLSESADTIGSLNATGSAELFDPKLFPDQSAVPDAAELETRSKEAITNLEEEEWGAVLRRQRNTLLRTAIATANGSLFELDKAAVDVNDKFIKYIESPEFKETYPNSGWQGEKILAFFKNWATSIRKHPELGVAGPAGLLLAIPAGEDKDFEYPDIHTFINKRVEETTEYVRSKPPVLPRALDVSFVLGQSKALLNLPKDTLSPLSFLEVEVSSASEKPLSPLYLQTLVVRHTREIVDVMYGRMKESDLKDTDFAVQDPELLKNFRLLIAMKLGAVHDADRVAEIQRRHPSGYDPELLNHRGLVRAITPYIPVVLENPTDPVPVSHYLTMVSGLEKTLVDEALQARVAKYVETQDEATKSFWEEQKKNFNSLKAIAEKITGVLARPPSMPGDFLAKHKPTCVSKGQDETMCQYLVEACYFAENMGDEFVNQCLDAAVSLEKTREHKVDLCAKFPSYNSCELAIHDCDKTYRNSMYTVLFECAARAAPDREAEYAKMAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN00</accession>
    <name>A0A7D5YN00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">YAF9</name>
        <name evidence="9" type="ORF">G6M90_00g014160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549106.1">
        <property type="nucleotide sequence ID" value="XM_014693620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN00"/>
    <dbReference type="GeneID" id="26238550"/>
    <dbReference type="KEGG" id="mbrn:26238550"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="8">
        <location>
            <begin position="10"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="243"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="275" mass="30932" checksum="B6BDC6E4C87887E1" modified="2021-02-10" version="1">MAPSNQLGKRVKLTQVRRPFIVGTTAIPFSETNPKPPGTPDNHTHSWQVFVKGLEDTDITYWLRRVQFKLHESIPNYVRMIEGEQGKPFVVNETGWGEFDITIKLYYVNDSGEKPQTMYHYLRLHPFGRTEEEKQSMVTKNGEVRSWSYEEQLFNEPYEAFYQILTSGAVPKGWKPSGASGKGKGKGKNRAPPPLPAPDSGEVWEHTAMIPNHNRPGQPFSRETEAAEVRKLKEAQTKTEEMAAQILSELKAKEELLAKLKAENQAAAAAAAKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNB2</accession>
    <name>A0A7D5YNB2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g025130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985748.1">
        <property type="nucleotide sequence ID" value="XM_066129951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNB2"/>
    <dbReference type="GeneID" id="26237513"/>
    <dbReference type="KEGG" id="mbrn:26237513"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014047">
        <property type="entry name" value="Chr_Tranpt_l_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33567:SF3">
        <property type="entry name" value="CHROMATE ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004810">
        <property type="entry name" value="ChrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="51377" checksum="65F39D75A38F7096" modified="2021-02-10" version="1">MTVNSWDLSLQRAVRSSWEATRFNWYLGFTAFGGPPVHFKIFRDKFVVKLRWIDEQLYQELFSISQALCGPASTKMLYCINLIHGGLLAAILAFLIWSLPGALGMFGLSIGVSNIQDTLPREVYALLSGLNAATVGIIALAAVELSGKAVTDQLTRILVFLAATAGMLYNALWYFPVLMVLSGCAAVIHDYRWLHRPVRNVKSLWVRLGGASPEPGRVVGEGGSVPGEHDVPPSEDPEPRTIPQEYRLEFSWKVGTAIITAFFLTFIVIMVLRGVLRSPPMLFKLFANLYLAGTIIFGGGPVVIPLLREYVVAEGWVSPRDFLIGLAITQAFPGPNFNFAVFLGSLAAINSGYSSVAGAILGFLGIFLPGIILVHGTMGVWSALRSRPWVKSGLRGVNAGAVGLIYAAVYRIWQVGYIDEGFQSGKSLGDDPWWVVVTATTYVGGRHFGVPAALAIVLGAVLGLVRYGVVSARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNU6</accession>
    <name>A0A7D5YNU6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g025510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548032.1">
        <property type="nucleotide sequence ID" value="XM_014692546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNU6"/>
    <dbReference type="GeneID" id="26237476"/>
    <dbReference type="KEGG" id="mbrn:26237476"/>
    <dbReference type="OrthoDB" id="4951635at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="108" mass="11668" checksum="E17621552A854263" modified="2021-02-10" version="1">MLPTDAASKTTMPSSKGIRLHDEDEKAKKANSRGKCLSAVAAFPGLIVASMGQFFAACCSCTRPTDDEAQDDCETLLDGKIIPFPRHAASSFLRTGTPRRMREANHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPV6</accession>
    <name>A0A7D5YPV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">smd2</name>
        <name evidence="14" type="ORF">G6M90_00g003780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542032.2">
        <property type="nucleotide sequence ID" value="XM_014686546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPV6"/>
    <dbReference type="GeneID" id="26245063"/>
    <dbReference type="KEGG" id="mbrn:26245063"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 14" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="35"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="117" mass="13515" checksum="1DC5757411C8F6DD" modified="2021-02-10" version="1">MADPKIQELLNKPRNELTEYEIAELEEHEFTSGPLSILQTAVKSHTQVLISIRNNRKLLARVKAFDRHCNMVLENVKEMWDETPRLADGKKGRPVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRF1</accession>
    <name>A0A7D5YRF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g039130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547268.1">
        <property type="nucleotide sequence ID" value="XM_014691782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRF1"/>
    <dbReference type="GeneID" id="26239831"/>
    <dbReference type="KEGG" id="mbrn:26239831"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="274"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="358"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="400" mass="45258" checksum="47080CDA9D8A70EE" modified="2021-02-10" version="1">MPRLLNRSRPSGVDSSPARTSSSTSLPRYQPPSCPLNDRARRALGELSDNRGTQHYESHLKDSARHLGLSVGDLHERLRAQHDRLQLLQERREQKGTNKTPEEERLEAHLVELEREVDELTHESEQSIRDVIDRRAGIEDQSALLGDLYTTAATAIAPNTAETRARRGVKQEPARDEEQDPEQQQGEEPVASTLEAFRKGRATKQAEYEQLTPYQRYGVNNDYAGFKKIWHDAASGEDGPPLPDASRWFRSDGRPVMTRPGATTRRSTIGPAGDDDDIAVAREVLSLNCPLTLRQMEEPYSNVKCKHTFEKSGILGYLPARGEVQCPQTGCSQKFSKSRFQQEFYLDEAILRRIQRVKQTQRTRDDMDVDDDEDAAGGDASLVFEEERRVPGRIPKKERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSH8</accession>
    <name>A0A7D5YSH8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g065770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986925.1">
        <property type="nucleotide sequence ID" value="XM_066130810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSH8"/>
    <dbReference type="GeneID" id="26247005"/>
    <dbReference type="KEGG" id="mbrn:26247005"/>
    <dbReference type="OrthoDB" id="4937353at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="420" mass="47209" checksum="4C49E553FAA6C970" modified="2021-02-10" version="1">MSVQTKSDLSNLAEALTCLLRVSTGKELQHLVNEHPFLDELTAASSSERGSEMKHLKGALTEFLTNGNVFLKAVEQFLLAHRYQNLAAYMATDSTLGSYFLRLLDAALKKYKSKTCLEDSGDQRYPAVDFGSILNQVQGLQLDQDLLHEIQDVVVKRSEMRTPASRITCHGPIHFKDSEVQDMLKTIEPKTPRISEQLFKRLVGKKNEIHRDVIESMTAGFVFVDHGYFRVWNQIGENLRQLCYLTGANIASSTTDTPWIIPALRAAVDSRTGTLAITQGIIQQQSIEIHNQQQVITSLIFRSLMEQIPPAGMDKKSATSRWQGFWDKAVKVAEAKDDERNPEHPLRGILTPQLKNRGREMYGTLSFGIHNYRDCAFFVDSTTFTALDSKILKALTPAGTSINEDGTVDWVAERKRYGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSR9</accession>
    <name>A0A7D5YSR9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g070750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986991.1">
        <property type="nucleotide sequence ID" value="XM_066130940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSR9"/>
    <dbReference type="GeneID" id="26247852"/>
    <dbReference type="KEGG" id="mbrn:26247852"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="611" mass="66217" checksum="CA659C31BEE3F240" modified="2021-02-10" version="1">MYLVERKVWELYDRNVDNIPWRQLAAEAARRNCQIADLMTLYPLELSTDRITEGDVVQATEYMRRRGLHSDAADLKGWMGLNTSGFVYLDITEPILLPGKGAESLGRAHRSGCIDIEQIKAVAIAQAEKMADESDRKCCINDASLGTAPRVIPRSVQDVGQDEIIRDGIHVTPRRNRHVRSGILSDMTSLVPISWHESDSLFGRSQLLARDGQPSAPTDGNAYEFARSTTAMAAMQSLINSSGAVQDKDSGLFGTAAGLEVSAVVSGGLSAGYQSLINRRETPATSVDQHDTTEEATEPPVAQGSRNLREFRKEIEALSNPVAAANTNSEKLRRALLSRFKHYLQEDNKAPVSRPRAPRPAPIEVVEDDSDYTPGRSTGKRRRQSVQAQKTPVKQRKLDTTPNTPVRCQSRGAPMTGSPGEAIKPLNLISIDASQKAGEQEGAGLASHAPPSPGSVVAVSPCSRRPSKGPGAGGEPTKGKKNAAPIFGLHRNQELTRPVDASENAEYAWSADEAGFAANSQFARYALRADRLRSGSRHWPEDALAALTRLKDEFHAVEFQQRGSTTRNAGEIRFAGCAGRAVYADFAMEAEFAMEVSCDGGGEVDGDERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT41</accession>
    <name>A0A7D5YT41_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine-protein kinase spk-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">spk-1_1</name>
        <name evidence="8" type="ORF">G6M90_00g030990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539640.1">
        <property type="nucleotide sequence ID" value="XM_014684154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT41"/>
    <dbReference type="GeneID" id="26247551"/>
    <dbReference type="KEGG" id="mbrn:26247551"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="79"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="467" mass="52355" checksum="A5C27342A1A2A635" modified="2021-02-10" version="1">MGFWLPRHISLCRATTARASSLSSCLKLHIASSSPRSQYSTTSTPPAEYGYIHGVEHLSDYRPGGYHPLHIDDRLHKRYRIVHKLGHGAFSTAWLAIDEKTTKYVAIKLGTADADRSELDMLSQITQSPVSRSILEDQPSPLPVVLDRFDVGGPNGTHPCLVTLPARCSLRDAREASGSFLFQLDVARSLAAQLVMAVSLVHARGYAHGDLHLGNLLLQMPSSLNTLSVEQLYARYGEPEREPVVCLDGEAASADPGVPSYAVPSVWMGVPSNGITLGEAKLILSDFGVAFRPGDKSRFESYTPVVLRPPEAFFEPATPLTFASDIWSLGCVIFELLAHRSLIDGFLAPQDEITAQQVELQGPMPSEWWGRWEKRLKWYDEAGRPLSNASDIWSWERRFEQWVQKPRQSRGMETIREDERDALFELLRWMLAWIPSERPDITKVLKANWITRWALPSYQKGLEGRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTB2</accession>
    <name>A0A7D5YTB2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isonitrile hydratase-like protein xanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xanA_1</name>
        <name evidence="2" type="ORF">G6M90_00g029990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539713.2">
        <property type="nucleotide sequence ID" value="XM_014684227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTB2"/>
    <dbReference type="GeneID" id="26247470"/>
    <dbReference type="KEGG" id="mbrn:26247470"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="24764" checksum="49A82927979528CC" modified="2021-02-10" version="1">MEPKRVLVVLFEGFNTMDMNGPYEVFRMADNRNAFTVTITAEIEVTRSFEGVQVKRDIALDHNLLGLLGDFDVLVVPGGPTHLVELHAAKMGDFMKLIAAFNELAPKDNTVPKTLLSICTGALFLGYMGIFNGRKCTTHRGAYRSLQKVNMDAAAGQDVAGGVMQARYVDAGSNEYGTRIISSGGVSCGLDASLYVVEIYDGIETAYGVADILDYKWRNTECFVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTU7</accession>
    <name>A0A7D5YTU7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-binding lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g063860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986785.1">
        <property type="nucleotide sequence ID" value="XM_066130766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTU7"/>
    <dbReference type="GeneID" id="90967857"/>
    <dbReference type="KEGG" id="mbrn:90967857"/>
    <dbReference type="OrthoDB" id="4487417at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16240" checksum="EAD2E009143A0F6B" modified="2021-02-10" version="1">MPQYQTPFYGRDSGHPFSLYPYAHSSIVKVLEIWSGWGSGDANGHWVIKGIQLTWFTGEKKGLYNHPVDTDVYSRYEFGGNERASFSIRAGWRIHKFGFQTSTGILWDAGGDSGNLFLDIANGSIVGFEGSSGWELDYLRMRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU06</accession>
    <name>A0A7D5YU06_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g086090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987332.1">
        <property type="nucleotide sequence ID" value="XM_066131279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU06"/>
    <dbReference type="GeneID" id="26246157"/>
    <dbReference type="KEGG" id="mbrn:26246157"/>
    <dbReference type="OrthoDB" id="5367487at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="661" mass="73043" checksum="D0F7ADE25F75863D" modified="2021-02-10" version="1">MAVNPSVSEPDGSSFSAFQNRAASMSSASSPSSQAQSTTPAAGVADAEKSTPPDMSNDGRSRESTVPAACLACRSKHLKCDGQTPCARCVNTQNECVYVASRRGYKGPRRGTVQNPNKRQATSPPDLSPSSSDCPMLLGARTGSANMPTVMGSTFGPPGIPAQDTQATQFPQAQPPTNMQLYKSYCAVNGIEPSPWAANQNGSRLTMHIPVPTTEERCFDSFYHHFHASHPFVLPPNFLSHISKEASLKPVLAAMRWIGSIFLDVGSPTRERLFNEAFSLICGPNRSKDGFLVQAMMLLIVGLDGSCQQDRARSILSEAETFALELGLNTREFAANHGRGIPVLEESWRRTWWDLFVIDGMVAGVHRATNFLLFDVTARAALPCEEDQYMSGRIPIPLYLDDLEDQDFSGEDREFSSFAYRVLCARNLGKLMRAPPIFGPEDENLGKIETLLTNWRLHLPQSKRDALQKNGQLDEMMFQAHMMNQATSIMLHQPHSQLDSSPTQDINSCAPHQAIPAGDLFNSHTRHTIESANSISTMITHRVSLLSHTHFFTCVITLSSIVHLSRWALFFIPHDDDDLRQQIRLNIGALNRLSEVWGAADRARGQVKAVAQEIYKVKKQQRSNSQFWLGLSQEEMLNTIATDDSIINEIENFEPIPNLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUK2</accession>
    <name>A0A7D5YUK2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zuotin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">zuo1</name>
        <name evidence="6" type="ORF">G6M90_00g082220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543453.1">
        <property type="nucleotide sequence ID" value="XM_014687967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUK2"/>
    <dbReference type="GeneID" id="26243630"/>
    <dbReference type="KEGG" id="mbrn:26243630"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="445" mass="50616" checksum="F476888EC1C35117" modified="2021-02-10" version="1">MATVMQVNDLPLPILPEGWNAEKDFKAIGQLSGAVQRSIEPVGPHFLAHARRARHKRTFSEDDRIQAQESAKKVEDGDESDESEAEDPMMLQREAKDWKTQDHYKILGLSKYRWKATEDQIKKAHRKKVLKHHPDKKAAQGRTEDDQFFKCIQKATEVLLDPVKRRQYDSVDEEADVEPPTKKQLQKGDFYKLWSKVFKSEGRFSKTHPVPTFGNAESTKEHVEDFYNFWYNFDSWRSFEYLDEDVPDDNENRDQKRHVERKNANARKKKKAEDNARLRKLLDEASAGDERIKRFRQEANAAKNKKRFEKEAAEKKATEDAKAKKEAEEKAQAEAEAAAKADRESAKKAKEAAKNAVKKNKRVLKGSIKDANYFATGDVSAAQIDAVLGDVELVQGKIDPDEIAALAGKLNGLTVADKIKAVWNDEVKRLVDAGKLKDGEAKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUL5</accession>
    <name>A0A7D5YUL5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase BOA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BOA1</name>
        <name evidence="4" type="ORF">G6M90_00g075170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545579.2">
        <property type="nucleotide sequence ID" value="XM_014690093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUL5"/>
    <dbReference type="GeneID" id="26241612"/>
    <dbReference type="KEGG" id="mbrn:26241612"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="431" mass="47476" checksum="E0EAB0CB8640ECA6" modified="2021-02-10" version="1">MAQGHDRPCPWTPTRPLPPDSVRNRALGAFDTMTVAGSSDGFIWAIGRHGAKPPVPIAKNVLGNHAHAHPSLSFAHIGPLCLRPIATPHRPIPAYREERREEEHLARGGQRLAPNMMRIAVAGGGGLGYLLALQLSQAANAYNVVVLSRSARPEFGQLDVQLHVVDYSDHDKLTFALQGVDLAISTISGTEQLSLINAAGRARVRVFVPSEFEGSLSRRPSHNDPLDRGSTQAIALLKQWESASRMKYTVFACGIFMERFHPYGLGYLNIGYGSGVSAVGDYLLDINHATAEYAAENSKGHTVRVCLTSVYDVVRFIVAAIDLGPRNWPHEFTMRGDRMSVRDVVGTCSRVRNVAFDHHMRQSSELQSYLAYFVQAGDGDKVAYYQRLIATTNGRYDFSRASLNDALEKSGQGDVQPMTLLRWLTNVWQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUZ4</accession>
    <name>A0A7D5YUZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">aac</name>
        <name evidence="17" type="ORF">G6M90_00g071320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545927.1">
        <property type="nucleotide sequence ID" value="XM_014690441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUZ4"/>
    <dbReference type="GeneID" id="26241960"/>
    <dbReference type="KEGG" id="mbrn:26241960"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI70482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="315" mass="34110" checksum="B64DA46D236D8F56" modified="2021-02-10" version="1">MSGEQPQKVLGMPPFVADFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKAGRLDRRYNGITDCFKRTMADEGVMSLWRGNTANVIRYFPTQALNFAFRDKFKKMFGFKKERDGYAMWMAGNLASGGAAGATSMLFVYSLDYARTRLANDAKSAKSGGERQFNGLVDVYRKTLASDGVAGLYRGFMPSVAGIIVYRGLYFGMYDSIKPVLLVGNLANNFLASFMLGWCVTTGAGIAAYPLDTIRRRMMMTSGEAVKYKNSLDAARQIIAKNGVKSLFNGAGANILRGVAGAGVLSIYDQLQLILFGKAFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUZ9</accession>
    <name>A0A7D5YUZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g097600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546581.1">
        <property type="nucleotide sequence ID" value="XM_014691095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUZ9"/>
    <dbReference type="GeneID" id="26241004"/>
    <dbReference type="KEGG" id="mbrn:26241004"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000075">
        <property type="entry name" value="RWD domain-containing protein (Gir2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="229" mass="26254" checksum="5B4E4CD150A64BEF" modified="2021-02-10" version="1">MGREDQVEEREVLESIFPEEITDLSETEFQVSITLDILDEEDQEAPSFILQVRYPDEYPDVAPHLDLLAAQNSPSHQHFSISDDREQLLETIHETIQENLGMAMVFTIVSALKEAAEQLIQDRKDSAARVHEEALLAAEREENKKFHGTQVTPETFLKWREGFLKEMEEKERLEEEERLAELKKAKIKEPIKLTGKQLWQRGLAGNGDDEEGDEEDVPTDGVERLAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW13</accession>
    <name>A0A7D5YW13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">eif3a</name>
        <name evidence="7" type="synonym">TIF32</name>
        <name evidence="10" type="ORF">G6M90_00g015270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986026.1">
        <property type="nucleotide sequence ID" value="XM_066129767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW13"/>
    <dbReference type="GeneID" id="26238442"/>
    <dbReference type="KEGG" id="mbrn:26238442"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="338"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="821"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="901"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="938"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1059" mass="120745" checksum="109E1567BB0954EC" modified="2021-02-10" version="1">MPPPPHQKPENVLKRAHELIGVNQAPAALNLLHEHVTSKRSRNVPIASLEPVMLLLVELSVEQKKGKLAKDALYQYKNISQNTNIGTIELVLKKFIELAVEKVTAAQQKADEVQSSIDATTTTNVDDLEATETPESILLATVSGEQSRDRTDRAIVTPWLKFLWEAYRTVLDILRNNARLEVLYQSTAMQAFDFCLKYTRKTEFRRLCELLRNHVQTAAKYSSQMHAINLSDPDTLQRHLETRFQQLNVAVELELWQEAFRSVEDIHTLLSLSKRPPKNVMMANYYEKLTRIFLVGENYLFHAAAWSRYYTLLRQSSFMVASGQGKKADNPPASDADLQKAASFVLLSALAIPVISTSRSRGAMVDFDEARKNKNSRLTHLLGMTQAPTRNRLFRDALSKSLLQRARPEIRDLFNILEVDFHPLSICQKISPILTKIGEDAEMERYIVPLQQVILTRLFQQLSQVYETVDLSFVETLAQFPEPYQVTRGTIEKFIMNGNKKGDLAIRMDHATGVLSFDNDVFSSAKAGSAGSAESETGTVQRLQSTPSDIVRSQLTRLARSLYTTCHYVDPNFNKERVAARQAALQRAKAGTEQERQDILARKETIQKRKEEASELQARREKENARQKRLREQALQEAEDKRLAAEQKDREAKRLQAERDRVRKDELKKQIAELKMSDKVLDIDLDDLDNLDTNRLRAMKLAQLEREKNDVNEKLRITGKRFDHLERAFRKEEVKKLSEDYAEQVEVDRAIYEKVKVKTLKEAEEKHKESVELKHRLTRLVSYYEDFRSSLHERRRDEFEKRRRDAERELEKQIAARKKEFRDRKLREKREREEKERELREAEERAAREKEEQRQREEARKAELAKLKEQRDKERQEMLEKAALQQRREEEALARRKAEKGAAAAPSAPSAPLQTETPEGRKPPVIGSGSWREREASKNAAAAGAASGSESRPGPAMERTDSNDRSSGPPRLQLAGSGNKPSWRDRQAAKGDAPSSSDNTAPPATSRGFGGPRGAPPPMDRGGSNRGDSDRTSSPAPQSESLPPRTAGKWVPPHMRNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWG9</accession>
    <name>A0A7D5YWG9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Urea carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g084500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543665.1">
        <property type="nucleotide sequence ID" value="XM_014688179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWG9"/>
    <dbReference type="GeneID" id="26243842"/>
    <dbReference type="KEGG" id="mbrn:26243842"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="11"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="129"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1153"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1238" mass="133835" checksum="BE1B72FA2D7199D1" modified="2021-02-10" version="1">MGSTKFTSLRNIRKVLIANRGEIAVRCIKACREVQVHSVAIFTHADATSLHVTLADEAVLLPGDDGTAYTDGEAILDICKKTGADAVFPGYGFLSENAEFAGAVSSAGIIFVGPSSASIKAMGLKHEARAIAEAANVPVVPGTQLLSSAAEVVEAARDLGFPVMLKATGGGGGMGLQACDTELEVEKAFATVQSRASTLFKNSGVFLEKYYPRSRHIEVQVAGNGKIVIAFGERECSLQRRHQKVIEECPSPFVERHSGLRERMLQAAINYAARLKYKSVGTVEFLVDDETADFFFLEMNTRLQVEHGITELCYGVDLVHLMLLQADYERGGHVGIPSDILRGLQRHSPRGSAIEARLYAEVPLRDFAPSPGILQLVHWPEGDGVRVDTWVRSGQRITPLYDPLIGKIMVHSPDGRGAAQSRMLAALRDTTLQGTQSNLEYLISIVASSIFINGRTLTNSLSMFKFKSCSLQVLDPGVMTTIQDYPGRTAVGHGVPPGGPMDDLSARVANSLVGNDWGVELFEITLAGPELLFHEAAVVAICGAELPVTVDDTPQPMWSRVIVNKDQILKLGKVSGSGTRTYLAVKGGFPQIPKFLGSKSTAPELGFGGLQGRKLQAHDILALAEESGIWAAAATPLSLPAKAVPDFSITSVSCLDGPFGSDDILTPEGRKTLYEAQWAVSHNSGRSGVRLEGPRLKWARTSGGGGGSHPSNVFDYGYPNGGVNFTGESPIIFAHDRPDLGGFACPTTVCSAEMWKVGQLKAGNTIQLRSVSYDTALEITRKKEEYLGAIILYAKGSACQIPPLDVALSDEPPCSILHQTPPLGSHPRVTYRQGGDTSIIVEYGDQLPDLRNTACVQLLANGLLAANLDGVRGDPNFATLTVRFDPLLTERSKLLAHLIHLDGQIGETTGIKVAARQVRLPVCLDHTSLRESAQRYMENIRPSAAYMPDNVEYLRKNNALNTRRDVFDAILKAPWLTVAVGFYVGTPVMFPLDPWRVLTGQKYNPSRVYTPGGSVGLGGSLVAIYPVAAPGGYQLMGRTLGGWDSGGNRPGFSPEKPWLFNHFDLVTFYEVSEEEYNKMEQAFETGRYIFDITETTIDMDTYIARFDEAAKDPEYQAWRRRQVAASQEMGELEQKLFEEWTQAKSSGEGGSSFEDDGVDSGKVVLIESPVDANVWKVLVKQGDVLEKGQTVAVLEAMKMEINVVVSDDQAGAVVSTISQPPGSVVRPGAVVVRAVRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWN2</accession>
    <name>A0A7D5YWN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-linked oxidoreductase ZEB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ZEB1</name>
        <name evidence="4" type="ORF">G6M90_00g029730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541199.2">
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="476" mass="51586" checksum="7D73F8A495D94011" modified="2021-02-10" version="1">MSPYWNNNSCSPFLGPEMPCTLGNLASYAIDIRCAEDAITGIRFAEDNNIRLSIKNTGHDFLGRSSGGGSLALWMHNLKQVEFFDYASPLYTGPAVRVGAGVEYSEVYMAASARGYRVVGGSCPTVGLAGGFSQGGGHGPLGAAYGLAADQVLEWEVVTASGEHLALAGHGEHADLFWALSGGGGGNFAVVLSMTVRAHADGPVAGAGFSFTNPGNDTVFWGGITAWLRHLLVLHTFHRGITTVFAITAKSFALEFATLPDTNTTDTINAAMAPFVTQLSDLNISLAGSYQSNVHKDFAEHYSHWATQTYASNITLGGRLIPRSVVQDEVSGLPALVNTFRDIAHRGAVILSVAANVTNVNHIHNAVLPSWRDSLFTTTFARSLPQESTWDAILADYRQLNAWQEDLRVITPGAGTYMNEATWDNPHWKEDYFGSNYNELLAVKTKYDPRHVFWANAAVGSDEYWKATKDRRLCRI</sequence>
</entry>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
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            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35555" checksum="7A0D8A86B4A5645F" modified="2021-02-10" version="1">MDPELPSMPRRGTKRVSVQHTQERVRNNQRRHRARRKDYIASLEQKLIEAERTILTLRTQMEALQAPSTRRCSQRHDQDEQDSSMPLPLQTEHQDDIVDIFEAYSTVSGTRNITAWDPPILASTEPFISSTQPRSEVNSPISVSPILIAQSSELETELLQGTRRVSDQAIAEPNSLLPTTVIQNHVPAPTTACCSNNDLETDSQVMVKTKDSETIVLDQDTSPIMPRYLPEMETCYQVRPYESTMPCSEAFIIITQQNFKGMEQGDVAAWLWDGFRKPNQPSEGCRVQTGILFSLLAFISETAFEVPAKVMPWH</sequence>
</entry>
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    <name>A0A7D5YWT5_9HYPO</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g067220</name>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
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    </dbReference>
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            <end position="315"/>
        </location>
    </feature>
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        <location>
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            <end position="214"/>
        </location>
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        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="39957" checksum="D245C2E26AEF2661" modified="2021-02-10" version="1">MGKITIEFNDTEDIAMAIPLLLALSICPAMLGTQEGIRQSQAQNRREEHRSRRCNLMVSCIKPSVRKREIDGTLVMLKDAKLYLATHNLSGGHPFAGYYLPYPDSTYEGLVSTISDDPPMLNWIYVDKNTHEVKYGERSAAQQHLTGPFDCTRQDRRLTLEGWEGFAAVEELPGIWALYFDRDDDGLVTKVPLGTRVLEVELNRREKKEPKPSSDVEQPQTDQDDERAEQRETVDGAAETDSHDHPDATLGQGGRGMASDRVDSLDSTYSEEDVRLARSGVASGEHHDVDDLPGTPSVTTDVVSRSPLSWGYSEDDSNFFVDSPTPASSNFPVEHVVREERRTVYETPYVEDEDPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX23</accession>
    <name>A0A7D5YX23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g087240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX23"/>
    <dbReference type="GeneID" id="26244908"/>
    <dbReference type="KEGG" id="mbrn:26244908"/>
    <dbReference type="OrthoDB" id="2351940at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="376"/>
        </location>
    </feature>
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        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="61170" checksum="C5D3B638DE5824DA" modified="2021-02-10" version="1">MASRSGAGSGGHRANPTPPRDSQEDFPPLPLPRLPSLRTLSGERERSRPASPPSAAVSASATAATAGLNGRQPARYWSAAARRAERIRNLDDRAPSLDDLESNSMDQSWSSTSRRQPRLRPLDTASHHRRPNLDELDQTLDEANSQLRTLLDMTNRIDLMPPFLRSTQSPPTIRPHDFPDDNVRSKRRKIDSSRLVPSLKGFRYGKYGQVEPGQLQMEIVSCDGGMFSNESSYAAENILKDDSSVYCTKGNRCNIVLRHQGATVFTLEELVIKAPASMNYSHPVREGMVFISMNQDEILSRTAQYQIQYVSSNRITYDDPTPRHIVSIRHHNDGTTSTRVRRSLYPSHSYSHDHDEDDHRTPEMPQEFSTNQPDFRITTECTSDEEDYSMPHILRRTPNRIGFLPFETETSDSEDGPFTDDFTESFHRQIHPPSGSSTSHPSRPTHSHNERLSVSLAEAWDAHASATQEAIRAVGGELLVPHAKFFIEKKKSKCTIRFDPPVSGRFILLKMWSSHHDVASNIDIQSVMAKGYAGPRYFPSVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX85</accession>
    <name>A0A7D5YX85_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g108350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544011.1">
        <property type="nucleotide sequence ID" value="XM_014688525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX85"/>
    <dbReference type="GeneID" id="26243398"/>
    <dbReference type="KEGG" id="mbrn:26243398"/>
    <dbReference type="OrthoDB" id="4867118at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028846583" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="141" mass="13639" checksum="FF2DFAA36D392C5F" modified="2021-02-10" version="1">MRFAGSALVAATLALSAAAAPLPQNANGLTSLLSNIPIIGTFLGGAGGAAGSASPAGSTNNTGAGAGANPLATVQEHLPAPGSGIEGILSSGQILGDHIKYTSNPPSALEPIPAAQNSPPREIHRQAHAALVPASQRPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXU5</accession>
    <name>A0A7D5YXU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lanosterol 14-alpha demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cyp51</name>
        <name evidence="9" type="ORF">G6M90_00g011440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549378.1">
        <property type="nucleotide sequence ID" value="XM_014693892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXU5"/>
    <dbReference type="GeneID" id="26238822"/>
    <dbReference type="KEGG" id="mbrn:26238822"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="477" mass="54334" checksum="4D7800A6BE66F076" modified="2021-02-10" version="1">MALFTTIVILLAATAAAVLTLLRRRSPISLPGYKGEGSLAFLHDAKAFATKPIALIQKATRQCGDVFSIQVLSVYNVWLRGNQLNRVYLETREDVWSFVGGMGLFLNKIIDSGYWDHYRVLLSSLSRYVSSGPAQRYAATVSVEETQKAAAEWSLWDGFELFDSVSYLVHKIIVRSLMGEDFYEHNAAELFNLLHSMEADIGSLLSFILPDWVPHPPARRLLKARNRFKEIFMERLRERDRQERSDVRPLQDYVAFTMEDGATVPLKYLMPSHHTMLMFAAHTSTAASISWNIIALLRHPNVMKQVTSELRSMPEGQESLLFQACIKETSRYYCGMKLLRLARENVCIPGSNVNIPKGAVVSISPYLTHLDPENYSEPEVWNPQRWINNKREIVQIDNKTDGVKYLPFGGGSHKCVGEKMAMIMVVRTVATLLREYDFAWETEDIPDKTDFSNLNFDKVGTPWLRGGVRVRMRKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYF9</accession>
    <name>A0A7D5YYF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lcb1</name>
        <name evidence="12" type="ORF">G6M90_00g042270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547565.1">
        <property type="nucleotide sequence ID" value="XM_014692079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYF9"/>
    <dbReference type="GeneID" id="26240128"/>
    <dbReference type="KEGG" id="mbrn:26240128"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="124"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="516" mass="57269" checksum="F0525F8A64BD05DB" modified="2021-02-10" version="1">MEIEALHNQLSRVLQQTTSAFQKVPGSAVLVRYIRSSYQNDPVRSAIELVLILFFIRYLLSPSYSTHKQNFVKLREDEIDELIDDWAPEPLVAEQTVLEEAESDKLPIIVGPTGPKVKLLNGRTVTNLASYNFYNFNANEQIKEKAIQTLRTYGVGPCGPPQFYGTQDVHVKAEADIANYLGTEGCIVYAQSFSTVSSVIPAFCKRGDVIIADEAVNYSIRKGLQASRSNIKWFKHGQMDDLERVMKAVALEQAKGKRLTRRFIVTEGLFETCGDVTDLPSLVELKERYKFRIILDETWSFGVLGRTGRGLTESQNVDPQQVDMIVGSLSGPLCAGGGFCAGAKDVVEHQRITSSAYTYSAALPAMLAMTASETVNLLQSNPDILSQCRENIKVMKLQLDPRSDWVVCTSALENPIMLLVLKPEVIKAKRLSIEDQERIFLECADECLTNGVLVARLKTRPYAHAIKARDSSWVAQPALKICITSALSKKDIEKSGATIRHAITKIMTRKISGKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYM5</accession>
    <name>A0A7D5YYM5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">POL12</name>
        <name evidence="9" type="ORF">G6M90_00g003750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542029.1">
        <property type="nucleotide sequence ID" value="XM_014686543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYM5"/>
    <dbReference type="GeneID" id="26245060"/>
    <dbReference type="KEGG" id="mbrn:26245060"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000008">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="8">
        <location>
            <begin position="233"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="379"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="664" mass="72669" checksum="A2440AE9697D3EE0" modified="2021-02-10" version="1">MAESDIQTRFSPNSPLEPDIITEIQSILRLHDLSVDDLFFKWESYCIKMDLDAQAGLSLSRIRNLKQSIQDELEKSHRATQVRNERKVLSATPKASSGGDVFGMLDGLVPSTPATARLNRSGGVGGSALKKRMDGLKVGSSPARMDDQLKAMNGLPCVSFVLDDWFRTDFDIRTTSFADRLNPGDVVEVLNGHLQPAEAPIAPFAEPRIKLTAASDIKKMAYKPLAMKLSEASEILDDRIDEFITVVQDHHKLEDSAFGSAASQSTTEVVAVGRIASDSMEGRLNTASLVLETSRRTGMGLRVPLRMEKIRTWSFFPGQIVALRGHNATGNEFVVHEILEIPLLPNAASTSSALEAHRAKFRGHADAMDSDAEPAPLTIMYASGPYTADDNLDYEPLHALCSRAADSYADALVLAGPFLDIDHPLIASGDFDLPDEAVQDPDTATMNTVFKCLFAPALVRACSANPHLTVILVPAVRDVLDKHVSWPQDAVLRRELDLPKSVKIVSNPMTLSMNEMVVGISTQDILYELRSEELAKTSGDLMARLVRYLVEQRHYFPLFPAAERTRLPKTGTEEGLATGAVLDVGYLKLGEMVNVRPDVMLVSSSLPPFAKVVESVLAINPGPLSKRKGAGTFARMTLHPPAVGEDEMQSHKIFDRARVEIVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYY7</accession>
    <name>A0A7D5YYY7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CYB2_2</name>
        <name evidence="20" type="ORF">G6M90_00g094640</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540828.1">
        <property type="nucleotide sequence ID" value="XM_014685342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYY7"/>
    <dbReference type="GeneID" id="26246441"/>
    <dbReference type="KEGG" id="mbrn:26246441"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="104"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI73321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="483" mass="52421" checksum="FB36D8A10051C5ED" modified="2021-02-10" version="1">MTRKVSVSEVLQHSSPESAWIVVDGNVYDMTDFAPSHPGGPEIIHQYSGRDASVPYNEVHAPSLIKSSLDAKHHVGTLDAATVTESWTAANTPAPQAKAASSKPPLADIINMYDFEKAAHQSFTNKAWAYINGASNDSITRDINIETLKKIWFRPAVMKNVSRVTTRTSLFGCRLDAPFYVAPTGAVRTAGEEGELALARGAGPSGIIHCISTPASYPHDEILQATPEHAFFQLYVDKDRAKSAKLLRQISASDKVKAVFVTVDLPVVSKREDDERVKAENTVEKQVSPGQDQKGAGLARQSGSFIDPAVTWDDIPWIRKHTTLPVVVKGIQRWQDARTAMSLGCEGIVVSNHGGRAADTAQPSIITLLELHRNCPEVFGKMEVLVDGGFRRGSDIVKAVCLGASAVGVGRPFLYAVNYGTAGVEHAVALLRDEIETAMRLCGMTDLMEEAGPDFLNTAPVDHLVYHGPHAYLGRKPRTRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0U7</accession>
    <name>A0A7D5Z0U7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GATA zinc finger domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gtaJ</name>
        <name evidence="9" type="ORF">G6M90_00g011250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986108.1">
        <property type="nucleotide sequence ID" value="XM_066129706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0U7"/>
    <dbReference type="GeneID" id="26238839"/>
    <dbReference type="KEGG" id="mbrn:26238839"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="425"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="477" mass="53227" checksum="35921E80B613FE1C" modified="2021-02-10" version="1">MEPGDSGSRPSVHPNPAIITEQHQRHHQPSPSAPPTSYQSPREHLERRYQEQHAMATATVLAPSSHYPQSSSYSSYPQHQTGTAPPPPSNSGSNMISSEHRRSSDDKEQPGRQSLPSISEVISGTRPGQYPPPSQPNLQPGSGLPSPFTPAPRSYSEPEKHSPRQLHTSSTYPPRQENLPAFTDSPRPPFNGRHSLPPVSDRRQTPPSKPDFPQHRLAESQQPSDAHASNGAYGHPPPPTSHPYPAGHLPPGQVPLPTYPISPRHAVPPPPGQYDARGQSVRHEEAEYPSRPRFEPTPTRHFEPWNYQEALSHTGSASRTLLCFAEAYGRIAQEQHGSHPLPERLPTEREVNDMLGNIDIIKRCLEQVRDAVQVSIQNERAREGTKIKGAFEEHQDVSMYDNGMKSQYTMTEVKKRRGRAAPPGRCHSCNRIDTPEWRRGPDGARTLCNACGLHYAKLERKRQLEARSLRPKPEDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1V0</accession>
    <name>A0A7D5Z1V0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">betB</name>
        <name evidence="9" type="ORF">G6M90_00g035180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546912.1">
        <property type="nucleotide sequence ID" value="XM_014691426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1V0"/>
    <dbReference type="GeneID" id="26239475"/>
    <dbReference type="KEGG" id="mbrn:26239475"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="509" mass="54186" checksum="4E2D7D15E4886117" modified="2021-02-10" version="1">MTFATEIHTFHSGRPQPQTSSSSSTFKSIDPTTGEPLATIYTTTPAQLNDAVAAARAAFPVWSQTPAPKRAAILLRAAALLRERNDALALTETLDTGKAWCETSTVDVVTGADVLEYYAQFIAGGLPGQHTRLRQDAYILTTHEPLGVCAGIGAWNYPIQIALWKSAACLAAGNCMVYKPSEVTPLHGNTLAQIYVEAGLPAGVFNVVYGDGPAVGAPLVAHPDIAKVSFTGQVSTGSKVASEAVKSMKSVTMELGGKSPVVILPDADVDEAADVAMAANFFSTGQVCTNGTRVFVPDTLLAAVEKALVQRCREGIRMGLPRDEKTNFGPVVSAAQRDKINMYIKHGKDVDRAKVLYDGSVDSQKDKPTPGGFWVPPVIFTNCTDNMRVAREEIFGPVMCVLPYKVAGKSREDWVAEVVRRANDTPMGLAAGVVSSDVGLAQDVLRQLDAGITWINTWGESPAEMPVGGWKMSGIGLENGHEGIQAYMRVKSTLVQLGKGACKGMFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z212</accession>
    <name>A0A7D5Z212_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BOS1</name>
        <name evidence="15" type="ORF">G6M90_00g010370</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549480.2">
        <property type="nucleotide sequence ID" value="XM_014693994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z212"/>
    <dbReference type="GeneID" id="26238924"/>
    <dbReference type="KEGG" id="mbrn:26238924"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI64429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="242" mass="27431" checksum="729E005543FCDA1D" modified="2021-02-10" version="1">MNVQYNSALRQSKSIRSELDTLNAKGSPTPGEIGNVSASVSSFTKIIDEYHRLARQEIVPKKQEEAFERVKRFREDLSDFRSQIDGLKKSRDEAQYQNNGRELLGRRPYNATPENPYAGTPTNTNSSFHPRHTSTAGAPLTTGSGDETREAHAFREQAFFQQTHSALDDYIARGQAVLGNLGEQRERLKNTQKRLYSVGTTLGISGDTIRMVEKRAREDKWLFLGGVVVFFAFCWLVLHYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2X5</accession>
    <name>A0A7D5Z2X5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anthrone oxygenase gedH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gedH</name>
        <name evidence="7" type="ORF">G6M90_00g057540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544335.1">
        <property type="nucleotide sequence ID" value="XM_014688849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2X5"/>
    <dbReference type="GeneID" id="26242747"/>
    <dbReference type="KEGG" id="mbrn:26242747"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="160" mass="16317" checksum="69D3198067B9608C" modified="2021-02-10" version="1">MQISGPPLVAVATGIVGSAWAAGAIASLSLIVIPVLKVSPESTAPAWADVYKRGAALMPKVAVGVALAYGYAAYDVQSHGGKWVGFAAAAGSMLAIVPFTLAVMTRTNASLQKAAKDGTPGSDPQVNSLLDDWAWMNFARSLFPLASAVIGAISFVNNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Z9</accession>
    <name>A0A7D5Z2Z9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g092540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541898.1">
        <property type="nucleotide sequence ID" value="XM_014686412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Z9"/>
    <dbReference type="GeneID" id="26245366"/>
    <dbReference type="KEGG" id="mbrn:26245366"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="59"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="364" mass="38945" checksum="AE549CB92BD14924" modified="2021-02-10" version="1">MEDLLRYTPSRAAVLTVSPFLSQKFFKRNPGLTEQICVQQAAQVLGCPASSILPAAVQGASSFTVTRSDARPGDLGVVQFRDLSSPLSRDTMALARRTYGHVIPACDVVTCGLGDKAHVYLMTLAGGIAVSAAQRNLYQDEGAERLTVTVADFASYVASSLSTARQNTDDALLSQAYDQLAVWEALPARFQPKLAEVRARLPAILGRQFPQVLNHADLVEMNIQVDDASGGIAGVVDWENASYGAFGVAIASLEVLLGICTGGGVWIWHPRQERLRAVFYETLCAELGRYLEGRHLDADDVEAARVLGLFVMYGAWAAAGADGHDSDGDGRGAALAAVCLEAGLGEGAAAQPFLRRYWGDRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3T8</accession>
    <name>A0A7D5Z3T8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase BOT5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BOT5</name>
        <name evidence="5" type="ORF">G6M90_00g030150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539728.1">
        <property type="nucleotide sequence ID" value="XM_014684242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3T8"/>
    <dbReference type="GeneID" id="26247485"/>
    <dbReference type="KEGG" id="mbrn:26247485"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="53691" checksum="D8D846D3DFFAB614" modified="2021-02-10" version="1">MATDKVFALGEFDDVVVRNSILYCMFLFNDVLDVSKLCTSLNSLLKQEGWHKIGARLRRNKQTGGLEHHIPVEFTESRPAFKLYQSQHAMGRAEHPIASQLPRMKTQPTVMMDPNKFRSLWDNPDIPTKMSHYLERDEPQLSLVIVSFDDSTVMTLVWSHTLFDFMGMGEMLRAWSLTLQDRSDNVEKPYPVQENPLTDLGRQPTELHKLHQLQLLGVSLLLISIRTLVEIFLYRQQSRIICVPARYLQTVREEALDGLSAASKGPEKPFVSEGDVLFAWWAQLNTAHLAADSSKPVNLTNALGWRPTLLPPNRPYLCNAVGFAHLLMPARDILSKPLGFVALQIRQCIVESRRREQIEAYASIWRKCFAKLPPLFGSANMHVVTCTNWTQARVFDLDFSAAIVPSRLDTTRPPTERGRPCYVQCCFHGAILSNVLIILGRDLAGNYWLSASTTRRRWGRIEAIMNTFKDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3Y3</accession>
    <name>A0A7D5Z3Y3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g083000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543522.1">
        <property type="nucleotide sequence ID" value="XM_014688036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3Y3"/>
    <dbReference type="GeneID" id="26243699"/>
    <dbReference type="KEGG" id="mbrn:26243699"/>
    <dbReference type="OrthoDB" id="4941552at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="34484" checksum="25C556188FE7EE6E" modified="2021-02-10" version="1">MAYPHRDRYDDGYYPPPSDDRFAGPPPRRHKSERHRRRSPDGIPYGEDAYPPRRGYSRREPPGPRGMTQPGSSGRRPRSPPPYYPPEPAPREPRKDSRREPRPSRPERDVPRSYDRNYPPARDYASPRDQPRRPHREEPEYRPRRDRASPPPEYRSRPREGRSYKSRPVSPEPISRPREFPAPKYGGGDDGKRPHRARSHERSHKRDVSPARGRDRAFPPTSKPPSSSRRKSAPAPTADKAKKQAWWQNPLVQAGARTAFAAGAQAAMQNRNDPNPWLGSKGAKVATAALGAALMDGFGKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4B4</accession>
    <name>A0A7D5Z4B4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g068910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540002.1">
        <property type="nucleotide sequence ID" value="XM_014684516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4B4"/>
    <dbReference type="GeneID" id="26247222"/>
    <dbReference type="KEGG" id="mbrn:26247222"/>
    <dbReference type="OrthoDB" id="10525032at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16103" checksum="7C1986F89D9B8E2F" modified="2021-02-10" version="1">MTNRHEGNESASSSSENNRGSAEEPDNTLKQQPLRPARAYIRGGPRNYGRGHCPGCRHDQEVDDNNNMDNNNIDNDDGDVSNNSGFIALNLEPDADAQARVQLPNRNWRMTRKQVIGTEVGVLLVVVRLIGVGVYKGNTGTTAGMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4L4</accession>
    <name>A0A7D5Z4L4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g043740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547708.1">
        <property type="nucleotide sequence ID" value="XM_014692222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4L4"/>
    <dbReference type="GeneID" id="26240271"/>
    <dbReference type="KEGG" id="mbrn:26240271"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF28">
        <property type="entry name" value="FRP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="276"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="582" mass="65412" checksum="43FF3E4DEB6FFFA0" modified="2021-02-10" version="1">MAWPYGFPSLTHEEKLLRRQTLDLYACIAHYSALVPALLFLLYRLLKRVASQVKSGSSSEQTRYSVVPNSPTVKAQLQRPSARFASQWRKVVWWFSDDVYFLGLHWGQKDEWVLGTIWTAWLLVLSIKGTGNDYFHLTKRFGAIAVSQLPIQYLLALKALNPIAWIFASSHEHINRYHRVLGRIIYGLLWLHLIFYNAYFIMQAIWLKRIFDSVVFCGVLASFGYHGIATTAMRKAREYSYRLFFITHLVVALLTPVLLFFHASSARFYIAEAFAIFILDLAVRRITTINAPSTVENIPGTTLVKVMSSIPVHKLTPFRATPGSHIYLSLPPQGRSAAVPSSKSAIFDYLYNPFTVAAVDAEEGTISLIARVRNGPMTNVLSAYSSATPRPPSESRKITLAVEGPYGTMATKYNDLLKWGATKVLLVSGGVGATFTLPIYQALQSELSSAKLQFIWAIRGAGDATWAVSNKTTGQVVLEDPNIQLYLTGDLGLREQDNGDSAGGSVELSSMRRTNGRLTANHNKKRPNIEKIVDDMFRGSPDESVAVLVCGPIEMNREVQRRVRPWVMKGRRVWWHNETFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6X6</accession>
    <name>A0A7D5Z6X6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g110510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543808.1">
        <property type="nucleotide sequence ID" value="XM_014688322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6X6"/>
    <dbReference type="GeneID" id="26243195"/>
    <dbReference type="KEGG" id="mbrn:26243195"/>
    <dbReference type="OrthoDB" id="5208775at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="552" mass="60941" checksum="CC0A45F569CEE487" modified="2021-02-10" version="1">MSPGSSPPSMMTPESDTGSPLSMSPSIQGYDPRAIIRQLLENYTKEDINRLVEEESCISPSAQGQLPEGVFSMPLLGPDRDSMQSRTTHQSHGQGPKPSRSLSGNASSQRSRRQSTTDRGTAAVSMTHRLDYACGFCAEENIRKTCTRRNDLRRHIENFHNSNAVWFCQHPGCRVAYDWQTAYQNHLRTAHGRSHMNVDEAKVKLCPQTVFACGFENCTQVFEAPHEDDTAATLKEYSGHIVKHFEEGSNGGRWTYSTRVRNLLRQRQVSALWDKAWPDMERPRLQWEPQSSMAARKTLEAGHLENLPFLLRFIVMLGSNPGDLSGLEGKLEPPVRRRCPKAQYQHRLSFDAHAQSPQLAVERDMGQFKVSTGGVGVEPGLYANIQPGHHVPRSIELVFNADHALAQSRSQGQVQFTDAAASLHPLTPPQLFYHGGADSALYPPSSQMLSTAMTPHQPSTGQYIAVAQEAESVVNPAAAGFHGLQQVSSIPGAMDMDMNSDSSNARRGNWMGGYENMGIHNSLPADGYDMSNPVTPEYSHMAGRYGSPARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7C5</accession>
    <name>A0A7D5Z7C5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g067400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540499.2">
        <property type="nucleotide sequence ID" value="XM_014685013.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7C5"/>
    <dbReference type="GeneID" id="26246606"/>
    <dbReference type="KEGG" id="mbrn:26246606"/>
    <dbReference type="OrthoDB" id="5207784at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="243" mass="27219" checksum="2303B6218F91A76D" modified="2021-02-10" version="1">MPIDEPCQIIFPTTLRVQGRYICAGDDEACKLYKLSHSLNYLIDTNQNVRVERLGVSEKEDNGDGSPATISHCHIFDLVCRSPDTVTPVSFYAKHNEQTGLCSFTLQLFRPSRFSSKKGFNFSRASQSTPDCEKHSDLLFSAVPGKKRDVDYEWRNAERCLLATESDGKDSRSLMLHGKMTTEDCDALVSAWMLRAWWEQTEGNSPKHLDDIAQRIQGTKGPAYKEAKATRFSIGASVSPGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7D3</accession>
    <name>A0A7D5Z7D3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g064760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540068.1">
        <property type="nucleotide sequence ID" value="XM_014684582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7D3"/>
    <dbReference type="GeneID" id="26247104"/>
    <dbReference type="KEGG" id="mbrn:26247104"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21112" checksum="77AAD3C8FED3A668" modified="2021-02-10" version="1">MSFLVYFAAYATANCFDSFYARNNCTDAAATFVSPCKFFATTAVGIGSCVYKDGYFAHAASRAPVPLLSYALFTARDVVTLFASCTLPTMIAPELAVFSGAVASRASEWFGSEESRLQVAGVMAPVAAQIVGTPIHLLGLDVHHRRDGFSAAARFKSVWRHFRVCAPLRMVRIMPAFGIGGAANTDCRGMMLGRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8A9</accession>
    <name>A0A7D5Z8A9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plr1_0</name>
        <name evidence="3" type="ORF">G6M90_00g076270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545474.1">
        <property type="nucleotide sequence ID" value="XM_014689988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8A9"/>
    <dbReference type="GeneID" id="26241507"/>
    <dbReference type="KEGG" id="mbrn:26241507"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="332" mass="35989" checksum="D95EBB8AEB6FA99E" modified="2021-02-10" version="1">MPTIVGKQVGPIGYGLMGLTAIQTPNSDEVNFTAIKTAIESGCTFLNGAEFYGSGPEENSLTLLRRYFAKYPDDAERVAINIKGGRDFKTLGFDGSPEGVARSIEHSLEQLGPVGRIAQWGMARKDLSHDYEDETLASIDGYVKSGMIDGISASEINATTLRSAARKFRISALEIEVSLFHTDALTNGLCAACAELDIPVIAYSPLGRGLLGGRVKRVDDLALDDMRRDLPWFKDENLLVNLELVQKVEALARKKGCTPAQIAINWLLALSKRPGMPVIIPIPGSSDPGRIKENAAIIDLTSEDMAEIDGMLQGFVAAGDRYPAIQMKYLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8I0</accession>
    <name>A0A7D5Z8I0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Procollagen galactosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g053830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541019.2">
        <property type="nucleotide sequence ID" value="XM_014685533.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8I0"/>
    <dbReference type="GeneID" id="26246325"/>
    <dbReference type="KEGG" id="mbrn:26246325"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028875362" description="Procollagen galactosyltransferase 1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49187" checksum="3FBD7B9FA017F799" modified="2021-02-10" version="1">MARRTNISSPGPLCFLLPLPPLTLTQPSLMQAPQTVKCAMKTESNTMLGFLGRRVLWPLGILIFISALFTLQRRHFTDGPSIAHSRSWDKSDSLKHVSNSTLGFQDILVVGMPSRTDRRDGMILGAALSGLKINFIDGVKGENVYEKAIPVPEDRNNHLKGPGLGSWRAHMNAIHDVVRRNLSSALIMEDDVDWDVRIREQLHDFAVSSRALTQPLRHQPGQYADPTYPNPVEGSPKKVPDMNFHSLPNTVQPLISPYGDNWDVLWLGHCGMHFVFEHSNLIAKGRVVKENDVSVPPKKNLWSINKPFSLVEEYPAHTRVVHHAQEGVCSLAYAVSQRGAQKMLREIALKPATDAFDILLRFYCEGTHDRTKQECLSVNPSLFSHHRPVGPIGASSDIGDHGEGYRQEASTDMVRFSVRLNAEVILNGSTNYIDQFPDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8M3</accession>
    <name>A0A7D5Z8M3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HDNO</name>
        <name evidence="8" type="ORF">G6M90_00g069530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987013.1">
        <property type="nucleotide sequence ID" value="XM_066130915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8M3"/>
    <dbReference type="GeneID" id="26246592"/>
    <dbReference type="KEGG" id="mbrn:26246592"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH"/>
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    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
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        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
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    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="527" mass="56228" checksum="2102273F9F86185D" modified="2021-02-10" version="1">MGGKRFPDFPPEGFKGRTLRRGDPGYTEARKIPNARYGSEPGLIAQCLDADDIVAAVKYCDAHDEPIAIRSGGHAIDGHAMPQDAFVIDTTPMKNIAVDPETGVTTVDAGVLLGEMDAATQEHGYVVPAGTVSDTGAAGLTLGGGMGYLTRRFGMTVDSLLSVDVVTVRGERLVASRDRNPELFWGLRGAGHNLAVATSFTYQARRVGPGVVSGLIIYAIDDAARILPRLDAVMARAPRELTIYPVALPAPPLPGLPGHMVGVPILVLIVVYTGAPGAYEAAMAGVRPLAAPLADTVRPASWLETNSILDVLAPPGRRQHARGGYLAGITAEVAAVVVDAVRAAPAPTSPGPSVAIALPCLGGANLDFPEDSTAYSRRGANWMWEVLGMWDTPGKDAEFVRWVDGVMAAMTPLSLRNGYVNLSCDRGPEWLRNLYGSREKWARICALKEAFDPHNRLRYNKNVARAALQAPASWSWVPSWVRPSWMGSVVWALALLVVCRVGVYLQPNWGLALYLVRRLGSSNSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8X2</accession>
    <name>A0A7D5Z8X2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TEL1</name>
        <name evidence="25" type="ORF">G6M90_00g086750</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542440.2">
        <property type="nucleotide sequence ID" value="XM_014686954.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26244954"/>
    <dbReference type="KEGG" id="mbrn:26244954"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1860"/>
            <end position="2461"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2566"/>
            <end position="2879"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2897"/>
            <end position="2929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2850"/>
            <end position="2887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="2855"/>
            <end position="2864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QLI71766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2929" mass="326566" checksum="3F0BC17D66303A4D" modified="2021-02-10" version="1">MSSSHMSTVMSLTSDVKSGSIKACDKAVDELISLLNPRNRTVNLADLGDKSYHQIFEALFNVVIRDRPALYDKRKKESARKVAAARLTKCASAIRMTAARGAPKLGRKTLLALIDHITQVLPDPDGDFVAPLIQDYVKALSEVLSRQPHVEFLARQDAKPWEACVDFLLDIVAYIIPSEAHSSLISVARPSPAPDASTPRSTMRSNNSNQGQKRAGLAEGEPLRDALEGLQYLSQASNAPIGRRGRNVTELAIRVLNMRHLSLGSMQAMCFSICNTIFARTQAEDLEYGLSLVKKLLPLMSYWWRAEKVSQDELIKGLRSEISKTIYLAHPHIEHVSSKWNEEIRNDIENLVDPLWQEYSKRGEPFRLQLHDLTFNQSALPSSTMHLSLFGIRNHNSEGEGHWALVQNLSFLESILLTRGGISARDTAGNSEQPRKRQRTRECLSRLRLKLRSRDVGTQRTALQLLPFLVEGFGIAGEDLTSILDDLVTYVSNKDPITASWALVASASCASLPRMSELDGDQWKQLWHLAVRSVSIPTTCRAACLLLHRIIEKDLLPYNTISEDIDGIVTTADVNGPGLVCDTSLALMLHLLHARNARLPSASQATSNHIIRWVFLKWNPNESAFASSVSVLIQPLDLVNLLRVCCGVQPLRWNEIAASLGTSLGATWRTQHEMAGFNDYLLLLKRGEPSYDIQPCIYRSDSGRQLQPAADSHSFYPSKKLAFELFSPKFDDLVELCSTWLKKPSDGGTQISLDRFQSLLSACIVGSLLLPQFADLNTPQSTSMESNLVDLAERSLVVALDSVEPEAFVDATLRVLRPCMPGMTTADLNRSHSHHSSFLHILTTISRVLDQRQSSTAVGTSLGLMDLDDEFDSQSSRATSASNPMPVPRQNVQLSTSPRVFHVETRMRLGLLRAIHDDSSQIGLLPEAWIDDLLLMSDDDLLCCQALLLEISNSDLVVGSESAYNIIQRLGSIISTSDYQCCEVALTTCIDVLDGLHNIWLNDNQDLAEGVGDLYNYFIKVCLPSNFFSAKAQMSMARLLFSLLSANPAYGTNLGLASCRTSLLNILSTGSMQVKCFVADRIAGIFDLFILMLHDEIFVDVLASLPTNPADTSGIAFRLLALSKLACRWPTLLRRCIYHIFETPGKISQSIDYAKWCLADISSTLELKSPKDLFRLFSRQLLYTWMEHDSINDIPFAIFGFKDLEDLLRSAQAEAIALAVMRTQESTSAALANLLGMTEGDLIKRNFSTALSYSMAYGDAFSETRNEKGEDYIRKKMGGKGYMEAIYINLVDTIATFFDLIDQEDNLEKIFRKHEDICYAADNLEAIKKLACSSSKLPPNQQPMFRAKYIIHDIFRLCQGTEFQFQDLWTPSLVLSVTRSLFNTVHPALGPLHACSVLRKVRLVICLAGPVALESYCLEMLLNSVRGFIVDAECADDALGLTQYLLTGGREYLTQKPSFLAGYALSTLASLRVFLESSQSSTTQESQFKATMNKTQKFHDWFSKYLSDYVSPSFQDDEQCNLFKSITYSAARIRSSGNAEKGTSESKLLLDILRDGATGSRLLNESSRELALKLLCGDFTIPATIREDIVETDAAAIEQASSVWKSCEAQDLSKNYLSWAGRVVGRSFAASGDIPEDVLKESGVSFYGHVAPSPNGSEMGLLYLLQDLTADQNSMMAGLAEAALRKAVSQAIEDEDEPLVVACQRSLSESLFTASQWGSFCSPDMKATQDSKLDGGQSIWEDSISSPSWLRRISTHLVSIVSDSILLSVLTPVLTEVPGFTEKAFPFIVHLVLCFQIEQQQAAKRQLSSAMKEWLRDDRPTATQNLKLLINTILYLRTQEYPKESSIADRMHWLDIDYAAATASASRCGMHKTALLFAELASSEVSRPSRRSSAHREHDINDVLLNIFENIDDPDTYYGLPEDASLSKVVARVEYENEGSKSLAFRGAQYDSHIRLRRREAETDGQALVKALGTLGLSGLAHSILQTQESLGVSNPSVDNTFTTARRLQMWNLPTPGNSEHHAVILYQAYQSIHNSTVLSDVQTAIYEGFGGIMKNIANCNLNATALRGRLAALAALTELDDVLNIADPSEVPSMITKFKNRSEWMRSGMYGDVGQVLSCRETSVSMVCQHISLLKHAKMSADVLRQMQVESMILSSGIYRYHQATQESLNIATALSDMIPLCENLNLHVDAAIKIEVANSLWDHGEMGTSIRMLQAIDKESSLPKQSIRVNRSDLLSKIGHKVSLARLENPHDIQKTYLGPALKELKREGSSEAGSVYHQFATFCDEQLQDPDGLEDLARLQNLRAAKNDEVKDLKALIDSTKESQLKAKYAHVLSKEKQWLELDEKELKRVEQTRSEFVQLSLENYLLSLISSDDYDNDALRFTALWLERSAEESTNKAVMKHLSLVPTRKFAPLMNQLTSRLQSQEGTFQKLLFELIYTICIDHPYHGMYQIWSGTKARAQQKDDVAVQRVRATEKVAQKLSANKSVANIWLSIDKTSKYYHGLAMERNPNKYKSGAKIPLKDSAAGQYLVSYLARYRIPPPTLHIEVSVTKDYSNVPFISKLEPTMTIASGVSAPKIITAVGTNGIRYKQLVKGGHDDLRQDAIMEQVFAAVSSLLKLHRSTQQRNLGIRTYKVLPLTASSGLIEFVPNTIPLHEFLMPAHERYYPRDLKGSQCRKEIFNVQNRTTETRLSTYRKVTDRFHPVMRYFFMEYFVDPDEWFVRRLAYTRSTAAISMLGHVLGLGDRHGHNILLDSRTGEAVHIDLGVAFEAGRILPVPELVPFRLTRDIVDGMGITKTEGVFRRCCEFTLDALREEQYSIMTILDVLRYDPLYTWSISPLRLAKLQKARDEEGGGEEPEPSDTAEAKKAKKQNGRTNEPSEADRALEVVRKKLSKTLSVTATVNDLINMATDERNLAVLYSGWAAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9C8</accession>
    <name>A0A7D5Z9C8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g066750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987183.1">
        <property type="nucleotide sequence ID" value="XM_066130840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9C8"/>
    <dbReference type="GeneID" id="26247625"/>
    <dbReference type="KEGG" id="mbrn:26247625"/>
    <dbReference type="OrthoDB" id="3744526at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="180" mass="20253" checksum="D452C01B52B35B1A" modified="2021-02-10" version="1">MPSSRCSWLNPHNIRVYTTRSKFSSLYKTISPNFKSNLSQNEVPNFSAPPVPAGKDATRLHVWIKRPSTYDDRSGAKHDGLYQLIKDTGGRHKDVVIGNSNGYYEYGLQFNDPSWQKKPNGDGAAVSDYAGPYVEVKGGHELYEYKGEVKDKRKTLNSISNAARTKISGKVYNHKSYNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9N0</accession>
    <name>A0A7D5Z9N0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TFB5</name>
        <name evidence="11" type="ORF">G6M90_00g076660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="9">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987238.1">
        <property type="nucleotide sequence ID" value="XM_066131060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9N0"/>
    <dbReference type="GeneID" id="26241470"/>
    <dbReference type="KEGG" id="mbrn:26241470"/>
    <dbReference type="OrthoDB" id="354at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13828" checksum="A6ABB3A40399EE83" modified="2021-02-10" version="1">MPRAIRGVLIECDPSIKSIIVNIDSDNHDFIIEDLDEERVVVKENMVPLLKQKLEDVRSNLPICKSVKSSLLTLVIVSQNDTPLTSIHSASGKTSRPSTSQVPNNHKNHNLSFVHRWPHQTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9N7</accession>
    <name>A0A7D5Z9N7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Non-structural maintenance of chromosome element 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nse3</name>
        <name evidence="3" type="ORF">G6M90_00g090220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541680.1">
        <property type="nucleotide sequence ID" value="XM_014686194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9N7"/>
    <dbReference type="GeneID" id="26245543"/>
    <dbReference type="KEGG" id="mbrn:26245543"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="34331" checksum="84D59A4E0A8E4FB4" modified="2021-02-10" version="1">MPVKQRRRRPVDDEDPEDGVPSRQRANRRDPDNDFDNDSEDGMDVDGEAGSSADDQLAKKLVRYALSCEYSRTPIRRDGIKERVLGNQGRSFKRIFALAQKQLKLVWGMELRELPVREKMSLQEKRQAMKSNSQAKIGSGAYILTSTLPDEYRSAAIIKPSRIPTSDDEATYVAFYTLVVSFIWLNGGELSEQKLRRYLLRLNADQNVSSEKTETTLKKMEKHGYVIKRVERPPLGQDGEQTITWHVGPRAKEEIGLDGVRGLVRELYGGSSEDLEKKLNASLGIKESPTTRDDGNEEETRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9S9</accession>
    <name>A0A7D5Z9S9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g092000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987508.1">
        <property type="nucleotide sequence ID" value="XM_066131411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9S9"/>
    <dbReference type="GeneID" id="90968120"/>
    <dbReference type="KEGG" id="mbrn:90968120"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="40" mass="4581" checksum="B95C4ACE7BE6E95E" modified="2021-02-10" version="1">MNERISHSPRWATFWATISEVWGGEEHEAAQSSFVKGMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA36</accession>
    <name>A0A7D5ZA36_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Proteinase R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PROR_1</name>
        <name evidence="12" type="ORF">G6M90_00g078350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987100.1">
        <property type="nucleotide sequence ID" value="XM_066131087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA36"/>
    <dbReference type="GeneID" id="26241306"/>
    <dbReference type="KEGG" id="mbrn:26241306"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028837389" evidence="9">
        <location>
            <begin position="16"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="163"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="412" mass="43288" checksum="F9DE54E6E85138F3" modified="2021-02-10" version="1">MRLLIFLSGLAVSIAAPGSAPRAVHAPLLIPRGDDASLVADRYVVYLRSGASEADHKDAIKSFNIKPRHEYKHLRRGFSATLDGNTLAGLRRHPAVDFIEQVTTSSISSSEPVNRALQNSTGTPIEQKGATWNLGRISNQKSTSEGESKYVYDSRAGEGTCTYVIDTGVDDTHPEFEGRALQIKSFVANSTVDDSADGHGTHVAGIIGSASYGVAKKTKIFGIKVLDSNGDAEGDRLIAGLEYVPVDAANRTCPNGVVVNYSINSKGYAKSINVAAAELAKKGYFVAVAAGNKPRDVAQSSPASEATVCTVGSIDINNKPAVDTGYGPGVDLMAPGVDILSLQPDNRTSLLSGTSMATPHVTGLAAYFASIYGKSAIPNMCQYLKDVAVKGAVKEQRLCTANLVATNAVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAJ0</accession>
    <name>A0A7D5ZAJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS efflux pump atnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atnC_9</name>
        <name evidence="7" type="ORF">G6M90_00g111670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543700.1">
        <property type="nucleotide sequence ID" value="XM_014688214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAJ0"/>
    <dbReference type="GeneID" id="26243087"/>
    <dbReference type="KEGG" id="mbrn:26243087"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="503" mass="54579" checksum="E62794DA4EF035F0" modified="2021-02-10" version="1">MATTHDSVHEARAETTPLLGQSTCREYNQEDEQTSNISARTVLILVGICIIAIDFGNYLSFAPQIDILEQIVCRRHGIARPGDASGPDCKADGIQAELAILVGWMAFCNQVPGIILALPYGFAADRFGRKPVLLLSLIGLILEEMVVRFILGTSDRIPAEAIWAAPLLQLIGGGPQIATSMAFTIITDVFPASQRSSIFFRLSAIILLGELLATPSSALAMSWTPWFPFLAGVAFEFIGLAAAFALPETMPARSRREAPLEERRAWPDDQQGTRKHVFSIRSLLQKWSLFRGHGISAKVMMNILLVTASFLMASIGREALQFVVQYASKKFSWTIAQSSLLITIKGVINLLSLLFLLPRFSFLMLKHMSTVRADLFLVQGSVFLLMVGTAIMALSQQSETFTAGVVSFAFGWGYYAALRSLATSLVLPSQAGALNTAIALAQSFGAMVSGPVLALSFRRGLAMGGIWVGLPYMVASILFSGAGGLVLCIRLPRQLERTRNGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAQ9</accession>
    <name>A0A7D5ZAQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spore wall maturation protein DIT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DIT1</name>
        <name evidence="1" type="ORF">G6M90_00g107620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544080.1">
        <property type="nucleotide sequence ID" value="XM_014688594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAQ9"/>
    <dbReference type="GeneID" id="26243467"/>
    <dbReference type="KEGG" id="mbrn:26243467"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="535" mass="59652" checksum="927D8D6C9D5CEB40" modified="2021-02-10" version="1">MAAVPDTCVARDTQHIYSPVGEMASLPPRSSIHGRFIAGFVRHTSGHLIHCFGPFPTRITPVWPQIRDHVLREECRPRNRLSQTSLPIKHAPETADSTERVPPSHEYVVFEMPRLADEQVIGLVLAPDSSPTPQSLELDMFFADLVLRGLRVDIKTHAGHLRDPDADVAADAIVHLFDTSLRYVGKHDKWLRGGRDVFRQQVRSFTSRGARVEFCLPAFPCKSSSTEKVLSQSPDRGEYVALSNLQRFLQEVEDVYGPGAKLWIISDGHVFSDCIGVDDGVVDQYGAELQAMNETIAHRLGGKDRIGFRSLPELFDYDGLVGASELPLVTGYPPLKPRLIGTKTTAKAELCRRILDMGFRPGDAEPMEDLIARDPALLALYRGFSKFMLEDLATNQYTRHLSRSQLRKKASEVAKEMMQRNQAYSNLVEMMFPHHVRLSIHAHDNAGPKFGIKMLGKHVIPTDVIPPTGEALDCCDHLHIPTPWHNCMVEIDGRLGLYTTKASAVWPAVRSGDATWVTGGECGSYVYFKKMESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB50</accession>
    <name>A0A7D5ZB50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g105710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987626.1">
        <property type="nucleotide sequence ID" value="XM_066131681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZB50"/>
    <dbReference type="GeneID" id="26245808"/>
    <dbReference type="KEGG" id="mbrn:26245808"/>
    <dbReference type="OrthoDB" id="3745274at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028842028" evidence="1">
        <location>
            <begin position="21"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="173" mass="18855" checksum="6433953AFF472182" modified="2021-02-10" version="1">MQFTFQKMILAGLLAVGAMAAPAVEDNNDVVKRDSNWQSHAKYYAMGGGRGNELYVDGTWSKPHSFTEGTPVGRCSARPLGLYQAPPGSDFQPISDVSCRCWISSNDPIGSKTRCVAGWKETDPADASKMIKFKLRFECSNWFGDCTSFSVLTDEGICESTPTNLCDGFTVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC40</accession>
    <name>A0A7D5ZC40_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Replication factor C subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rfc4</name>
        <name evidence="9" type="ORF">G6M90_00g108230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544022.1">
        <property type="nucleotide sequence ID" value="XM_014688536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC40"/>
    <dbReference type="GeneID" id="26243409"/>
    <dbReference type="KEGG" id="mbrn:26243409"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="39407" checksum="1930F8C220D2FAB5" modified="2021-02-10" version="1">MPATKTEERGESSTAASKAALASSSNASPNYELPWVEKYRPVFLDDVVGNTETIERLKIIAREGNMPHVIISGMPGIGKTTSVLCLARQLLGESYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPPGRHKLVILDEADSMTSGAQQALRRTMEIYSNTTRFAFACNQSNKIIEPLQSRCAILRYAKLSDAQVVKRLMQIIEAEKVEYSDDGLAALVFSAEGDMRQAINNLQSTFAGFGFVSGDNVFKVVDSPHPIKVQAMLKACYEGNVDSALDTLRELWNLGYSSHDIISTMFKVTKTIPTLSEHSKLEFIKEIGFTHMKILEGVQTLLQLSGCVARLSKINMDPKKFQVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDA9</accession>
    <name>A0A7D5ZDA9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g105340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987681.1">
        <property type="nucleotide sequence ID" value="XM_066131673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDA9"/>
    <dbReference type="GeneID" id="26245771"/>
    <dbReference type="KEGG" id="mbrn:26245771"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="49"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="45593" checksum="366935F59D6B1282" modified="2021-02-10" version="1">MDGLDYTKVPLGVPPAGQQSNLLDAESQAWIPRLAIYTTLPVALCFIIMRIGTRIRMKHSLGWDDYLSILSGCASSGLCGILLAERKYFASISTFFISPFSSTRRHIWPPLLGHTGQRRNIRVDEVYDVSAALTKVSLLALFLRIFARSRRSKMMIWAGIGFTVASYATLLGAWIYYSAPHQGEGWSDPIYRVRTGRDTPVISVVFGALAIFTDFYIIAIPITAISSLNLSTKKKFGVSALFVTGLLACAFSVAGLSPRIENYRLTMVHGTPDPFWVSCPSYGLAVAEINLGIVCACVPVIVPLLKGLLTRLSVTTSSWRRYWGARSKGSTDIGNLEAGKGSPAPNPSHVGRRWLSLNLGSQKPRGTPSSGTITVTQATEIHMVPYSELRSIDMDYHRYLGNGKNGSHAASAERGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ00</accession>
    <name>A0A7D5UQ00_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g020340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548511.2">
        <property type="nucleotide sequence ID" value="XM_014693025.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ00"/>
    <dbReference type="GeneID" id="26237955"/>
    <dbReference type="KEGG" id="mbrn:26237955"/>
    <dbReference type="OrthoDB" id="4760011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="937" mass="101010" checksum="BB9484EFCD198618" modified="2021-02-10" version="1">MDVSVLPKRDGGSGGLSLGGLLAISLCGGIVLFTSVGLFMAWRVKVRQRRTTKRMYTMPDEYSKTRLTKRPLVMTESAVGRLPSRLSSRFSLTLPPIIPLPPMLSYNNLNFFRSSSKRRAERKSWLNGEEFHGPSVKKDSKDGWFSRDSWIRQVPTVPNLRAAEEGGDGIRDAGRQNSQHRPSYEEYRKQQQQGEPYQFQNHPPYHQEPQAIHVQKRRSGSTLPTSQTTPNLSSQNDVPRGRQSAVRTPAQAHVRPSVTMTEMGLRDILRSTDQRLREGSSRSPAKDTPQPSPTRTSPAKTPSSRKSESGRAAGRHNRGTPSPSKSGNTASLPTQASAASIGSVANSLIAEATQELKLPEGMPSPRRLRGREWEPQDHQILPPSLPGLESPSHRSDSPQRSPQRSPQRSPQRSSPQKSPSKRQSADSDQSSSLSTLYSVGEPESEEQEIQRQYFLQQQRYRQEELQALTAGDDPFTDNGRARGRHVRQKQEQPAGPRPLRRTKTMSPSVLTTRANTSPISQPLRPLSVNSKSGPGRGLDLQVAPPRPLTLRASRTMGSGDVAAKRAPEQQPPMPEPQPDCSFTSDSVGSDDSEATALPACETPKAEWVAAADRGHSPTEGSPLTPGARGDKDADLSSSPFSEQEILSMLLASGGNRRALPQPPAAVASADGSVLPTGLSPRPSVKSAASSPRRKLSAASSCSSSLATPSRRAARRSSRDAAPALGATIAQLRRMNSVVSSYSAASVASTATVGAGAGEADSPTLPGIFTGQPATPRKQLSRPEASGSRHYLNVGKDSGGSSGSLPKHHWSMADLDGGFGRRRRQDPMKPRGGSPGGKENTLEGVEEGGGAARPDVRGLREAWLSATAPSPAPPSPAARPAHSTFRLRQGPVADLLAREGRAGWRDSAESLGLYDRDGFLLPSPEREARARRGRALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ65</accession>
    <name>A0A7D5UQ65_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547967.1">
        <property type="nucleotide sequence ID" value="XM_014692481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ65"/>
    <dbReference type="GeneID" id="26237411"/>
    <dbReference type="KEGG" id="mbrn:26237411"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="428" mass="47819" checksum="CA16254DA0E7DE7D" modified="2021-02-10" version="1">MSRLAPSKRWTSFEGWDYNGMKKRLEDLIATLNKKVLIDHAERIIGQKISVSEPFSAGQYWICFELVAEDETLVIARVRLPRHPNAAPTVSETDEQYSIACELSAMRFMRQRLSTVVVPRVYAYEGPGSQLATDAGAVYMLIEGFRGNTLQDSVPDLCGLPSAKLEHVMAQWATIQTALATLTSPLIGSISGITKTGEPIVNKLSSAASEGLMSPGPFSTAVEYFTALGEASLYRASRHESNQSMSHFHRLGALVFLDIVQSTPFFQASPAQYPFNHMDLGTQNIIVDDDLNFLAVIDWEFAQTAPWQVNYYPMPFPLSWSDESINTILDDPQHLAHKNVSRQTDARELYCRKFREAEAKLKEEGMPLGNEFAKVLESAASRIYGCFSKLGDVPEQDEGLVYEMVRLAFNFDVERANQYLGSMSDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ67</accession>
    <name>A0A7D5UQ67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g018630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548677.1">
        <property type="nucleotide sequence ID" value="XM_014693191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ67"/>
    <dbReference type="GeneID" id="26238121"/>
    <dbReference type="KEGG" id="mbrn:26238121"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43189:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1198.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43189">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1198.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="14739" checksum="CE83BB152201DF89" modified="2021-02-10" version="1">MAQPNLPASMRTVRQRDKLTPELALTQAPVPVPSQPADVLVEVAATALCYSELTWVSQNPRFFPPDKEPVPGQDMSGTVVQYGPGSSSSFSFKPGDRVFCRIDAYRRCQTDSDYSVNITILSERVMRITAKTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQM4</accession>
    <name>A0A7D5UQM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAS seventeen-binding protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LSB3</name>
        <name evidence="3" type="ORF">G6M90_00g025900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547992.1">
        <property type="nucleotide sequence ID" value="XM_014692506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQM4"/>
    <dbReference type="GeneID" id="26237436"/>
    <dbReference type="KEGG" id="mbrn:26237436"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="145"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="55157" checksum="5EA20ECD2C1AF622" modified="2021-02-10" version="1">MQKVKSKLPSWDTTKTQSKKGFDKAWGLLDKLGAPVNRWTNKIGSEAFWPTTLDKESYKAARILRSFCKDGFYTDDEPPTDQAGPKKAPKVIKKIPQKVIENAVGLAIFTTMRTGLWISGAGGSGVLVARQEDGTWSPPSGIMLHTAGLGFLVGVDIYDCVLVINNRKALEAFTKIRATLGGEISAVAGPVGVGGVVENDGKWKQANRPVFTYLKSRGFYAGVQVDGTVVIERSDENARFYGEKIGAADILAGKARHPPPEIKMLMETLRAAEGKADVDAAMMDELDEQLAPGDLSIQEPDPDGVVFGVPEPDDPDPYGVHALEREGLEILEAGTRQRPSSMQFEYHPSPSSPTYGRFYRRSMDTAVGGATPVSAASGSNSPWGRAVGAYASSDAGTQTDDAVIVASVRSEDGFERQDVQHKDGHAEPEHFYDVTDGENDVFVNGGNPWKTNEADRDSGVAIDESERLELAREADKPASRKAEEEEDQEQALQNVRREPPPLPPRKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQN2</accession>
    <name>A0A7D5UQN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PRP28</name>
        <name evidence="19" type="ORF">G6M90_00g012480</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549274.1">
        <property type="nucleotide sequence ID" value="XM_014693788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQN2"/>
    <dbReference type="GeneID" id="26238718"/>
    <dbReference type="KEGG" id="mbrn:26238718"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="303"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="517"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="671"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI63852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="714" mass="79315" checksum="6076543A66DE1319" modified="2021-02-10" version="1">MPLDIEQILRQKKAADAAAAKPRFIPKAQRERMAAEQAKREEDDKRRKAADEAQKRRDDERKWESRPNGPSSTSHRIPNGPTQPPTGPRAMNQRKGDSKKSDKVNGDKKSAEDIEATLFRSRYLGPEVNQQSSFSAKKKRMRTTEKKFNFEWDLEDDTSRDNDPIYKNQAVNRGGSLAGLGGEFDEEAERRARKRARLIEERDVENGKERAKGIMEDFYRARAKAKERAERTGLGRHWSEKKLGEMRERDWRIFKEDFGISTKGGAIPDPMRSWEESGLPQRLLDIVDRVGYKEPTPIQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISDLPPLTEVNKNDGPYALILAPTRELVQQIETEAKKFAEPLGFRCVSIVGGHSLEEQAFALRNGAEIIVATPGRLVDCIERRLLVLSQCCYVIMDEADRMIDLGFEESVNKILDALPVSNEKPDTDDAENAQLMKSYLGSRDKYRQTMMYTATMPPLVERIAKKYLRRPATATIGNAGEAVDTVEQRVELISGEDRRKKRLQEILSKNDFAPPIIVFVNIKRNCDAVARDIKSMGWSTVTLHGSKTQEQREAALASVRSGATQVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRVGRTGRAGKSGVAITFLGNEDADVMYDLRQMLSKSSISKVPEELKRHEAAQSKPVRGGARREKDDAAAGGGGGGGGAGKGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQS1</accession>
    <name>A0A7D5UQS1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LYPA1</name>
        <name evidence="14" type="ORF">G6M90_00g006330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549874.1">
        <property type="nucleotide sequence ID" value="XM_014694388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQS1"/>
    <dbReference type="GeneID" id="26239318"/>
    <dbReference type="KEGG" id="mbrn:26239318"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000010">
        <property type="entry name" value="Acyl-protein thioesterase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="238" mass="25609" checksum="C9CD3C839C020A22" modified="2021-02-10" version="1">MSAASSASSLRRVAPLVIPAAGRHTATVVFIHGLGDTGHGWADAVGFWRTRQSMNEIKFILPHAPHIPITMNGGMPMPGWFDIKTLVKGADEDGPGVLQSRDYLHGLIQQEIKDGIPADRIVLGGFSQGGAMSIFAGLTAPVKIGGIVGLSSWLLLNQKFKDYVPDGNINKDTPIFMGHGDRDPLVLYDLAKDSEKALSSMGYSVTFKTYRGMEHQACAEELGDVEAFLSSRLPPKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URE1</accession>
    <name>A0A7D5URE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Virulence protein SSD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SSD1</name>
        <name evidence="4" type="ORF">G6M90_00g003910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542045.1">
        <property type="nucleotide sequence ID" value="XM_014686559.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245076"/>
    <dbReference type="KEGG" id="mbrn:26245076"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="734"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1203"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1352" mass="148969" checksum="29954D37AC203243" modified="2021-02-10" version="1">MEPQQQQQQPQQQQSAQQQPTGGVPGPAGRRLHIAHRRSPSELTPLMSMFANPGMEQLAIQQQIELLQQQQQQIQATHQQYVNMGMIPPGQSLGHNGAFNPLQPMGNAFQFPNQMGQQNMAPPSQPHSHRRNQSAMPNMGMGPPPAPSSGASGSNFGNFEAPPAHNRENTGGRGGRGGSGGGHQRRHSLALADAKKAAEIAQQKRTTSGFQFPAAPAPASDKPDDENKPVAPSNLDISVAQGSNRGRGGHGRSQSMAVNGRGGSGLRSSAFSLGGDGDGRRGGGHARSGSRNFEGNWRTQGQNLDQAGNTGQTSSFQPGHRPRGSINQSVSSIGAFQYNPNQPQLMQLPGQMMIPQMYGQQLNPIQLSQLQALQAAQMSGQQFQGLQTSQHAGQLGGQQQQQQQRKTLFTPYLPQASLPALLGDGQLVAGILRVNKKNRSDAYVTTQDGLLDADIFICGSKDRNRALEGDLVAIELLDVDEVWSQKKEKEEKKKRKDITDTRSGSTNQGNRDSGNNEDNNAAEGGIRRRGSLRQRPTQKKNDDVEVEGQSLLLVEEEEISDEQKPLYAGHVVAVIERVAGQMFSGTLGLLRPSSQATKEKQEAERAARDGGNNRHNDSRQQEKPKIVWFKPTDKRVPLIAIPTEQAPRDFVEKHQDYADRIFVACIKRWPITSLHPFGTLVEQLGRMGELKVETDALLRDNNFSSDEFSDAVLRSVGLQDWSVAKEEESELAARRDYRNEKVFTVDFNGSAELGNAIHVKSRPDGKIEVGIHVPDVTHFVKPNSLVDREAKKRGTSVQLINRFCALLPPKLSSEVCSLGPDQERYTTSVVFNVNPNNGSVAEGDSWVGKSIIKSSGKLSLKDIDQALENASEFKNEVVPVNTVQILQAVAQKFREARLGAGGEPIAPLRLFQQLDDENNPVQDNIFDSTQALELVEELMHKVNSYVAQRLAEGLPEKALLRRQASPNPRRLQTFVDRMNALGYDIDASGSGALQNSLFKVDDTDLRKGMETVVLKAMHRAKYFIASKTPKQIWPHYSLNLPLYTHFTSPTRRYADIIVHRQLEAVLSEGKIEFADDVESLAKTVESCNTKKESAQNAQDQSIHIESCRTMDKKRQEANGDLISEGIVLCVYESAFDVLIPEWGFEKRVHCDQLPLKKAEFRKEKRVLELYWEKGVPSSAYVPEDERPKAAASQRMTNAMAAARQAEEAERVKKEREEAARKQTITGTISTDDVDALFDDDDEDNTSDLTEAMAGASLAERPTQSVPGSPARSASNAGKLHRTRSDSKVPVTDAVETRLTNKEKYLKLFKLREEGGDYIQDVTEMTRVPIILKTDLSKSPPCLTIRSLNPYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US50</accession>
    <name>A0A7D5US50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Regulator of nonsense transcripts 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RENT1</name>
        <name evidence="18" type="ORF">G6M90_00g010950</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs. Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549426.1">
        <property type="nucleotide sequence ID" value="XM_014693940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US50"/>
    <dbReference type="GeneID" id="26238870"/>
    <dbReference type="KEGG" id="mbrn:26238870"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000003">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="17">
        <location>
            <begin position="88"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="15">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="15">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="15">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="976"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI65271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1083" mass="119583" checksum="DD74FF6C569D8023" modified="2021-02-10" version="1">MEGAFTHVGNHLISDSAAAIKAGADDLSALDPDESLLYGKYEGGRGGRRRADDDDNQTEAFEEDENDSLNSVPVEGMSGLKLKAVDEEKELPPHACAYCGIHSPACVVKCLTCNKWFCSAKGNGTSTHIVNHLVRARHKEVQLHPDSTLGDTVLECYNCGTKNAFLLGFIPAKSDTVVVLLCRQPCASSTSTKDMNWDISRWEPLIEERAFLTWLVNAPSDVEQLRARHLSPNTIAKLEEMWKVQPSATVASLSIASNIDDDPDPVLLRYDDPYHYQNIFGPLVKMESDYDKKLKEAQSEDGLIVRWDYGLNNKHLVSFNLHKIESGDVKLAVGDEMRLRYNGELREPWEGVGYVIKIPNSQSDEVGLELRKTGNDKLVPTDLSHNFSADYVWKATSYDRMQLAMKTFAVDDMSVSGYIFHTLLGHEVQLQPVQSRLPRKWSVPGLPELNQSQIDAIKSVLQKPLSLIQGPPGTGKTVTSATIIYHLAKMSGNQVLVCAPSNVAVDQLCERIHNTNLKVVRLTAKSREDVESSVSFLALHEQVRLSEHNSELVKLSQLKNDVGELSSQDEKKFKQLTKAAEREILNNADVVCCTCVGAGDPRLSKMKFRNVLIDESTQSAEPECMIPLVLGCKQVVLVGDHKQLGPVIMNKKAAKAGLNQSLFERLIKLQLAPIRLTTQYRMHPCLSEFPSNMFYDGSLQNGITHEQRLRRDVEFPWPIAETPMMFWSNLGNEEISTSGTSYLNRTEASNVEKTVTRFFKAGVKPSEIGVITPYEGQRSYIVTTMQNSGSFKKEYYKEVEVASVDAFQGREKDFIVLSCVRSNENQGIGFLSDPRRLNVALTRAKYGLVILGNPKVLSKHELWHNLLVHFKDRKCFVEGPLTNLQACLLQFSRPKVSFRQKNNYQSQYGAGGYTNGRFNGSATPGRDFDSGSMMSYIPDDVSSIQGSAFGGAALNSAFPPMFSSFTPEQWPGLPGVPGRGNKGRSRATESIAGESVANSELTDTTTSVIGGKGVSQGGVSLGSGLHDAVTGMRPVSYTQSDRLKQYVESNGRIAPGSGFGRRYDDDEKSVSTAFHSQIGGGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USK0</accession>
    <name>A0A7D5USK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DAC_0</name>
        <name evidence="3" type="ORF">G6M90_00g003470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542003.1">
        <property type="nucleotide sequence ID" value="XM_014686517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USK0"/>
    <dbReference type="GeneID" id="26245034"/>
    <dbReference type="KEGG" id="mbrn:26245034"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF7">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="14"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="384" mass="41441" checksum="E77A918E07354A67" modified="2021-02-10" version="1">MPSKDDLLAKLTNILQKHISETSTPGLSAAILTHSTCHTLTAGHANLQPPQPIEPSHLFGIGSITKVFTATVILQLIEEGKLSLSDTVSQHLPPETYANIDDAANASISQLLRHQAGIDSWEDDPEWIAHGRGRYLVPAHVWSKTEPLGYIRRPKKTAPRSGEWYYSNTNYTLLGLVIEKITANTAESEIRARILEPLALRNTYLEGFEAARGHVPSRYHWVTDTFRSTAGICPSFPLVRDDLLDATTSNLSVEWTAGGMLSSASDLVKFGQALRDGKLLKPESLDTMKQWIGAATPGSEMGHGLFRMKFTGSGGSSYWNGHFGGVLGFTGGLWWAEDGDVVVGVFSNVGTMHAGSVAGSGAHVIVGTEFLGTARELADCDCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USP7</accession>
    <name>A0A7D5USP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547833.1">
        <property type="nucleotide sequence ID" value="XM_014692347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USP7"/>
    <dbReference type="GeneID" id="26237277"/>
    <dbReference type="KEGG" id="mbrn:26237277"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028972994" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30502" checksum="F7F8BD2812B31AF3" modified="2021-02-10" version="1">MLVRQIAVFHALIGLVCSHSWVERLMVIGTNGTMIGNPGYIRGAVSRLDPNFNDFKMQHLLPTIPDGLLTDKLCKNTQRNRTYTTDLPALQAAPGAFIALQYQENGHVTLPGLTPQKKNSGTVYVYGTLYPRDDELLSSIHNVWNTDGTGGDGRGRLLAVRNFDDGQCYQINTGPLSMQRQAKFHKAAMNPQGADLWCQNDIRLPVSIPFSWYTLYWVWDWPSSPSDHLPGGESEIYTSCMDIEIQPRVQLDEMNFVDGQDLNMAGIKEQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USR7</accession>
    <name>A0A7D5USR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein FLOWERING LOCUS D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FLD</name>
        <name evidence="2" type="ORF">G6M90_00g026370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547947.1">
        <property type="nucleotide sequence ID" value="XM_014692461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USR7"/>
    <dbReference type="GeneID" id="26237391"/>
    <dbReference type="KEGG" id="mbrn:26237391"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="529" mass="57943" checksum="3D3705FC45D25559" modified="2021-02-10" version="1">MSDARKSALRELKAQNKLPHVGIVGAGVSGLRCADTLIRNGFQVTILEARERIGGRVFQQDIGGHAVDMGANWIHGTKNNPIALLASMTDADLVPDEPDAIFFDSVGERIPANKAEHCVQLVADAFDKAIQHSKNLSPSIDPRRNVLDYVLEIVRRSPLDAESKIICEQMIHMYNSEIGDCIESQSLKYFHLEDGMDGDDAFVASTYKNILQLISKTARSAAAIQLGQEVVKVQTFSRNSDNKAVAVELAGGQVKTFDEVVITCPLGWLKRHKSAFKPSLPLRLEQAIDSIGYGALEKVFVSFPTAFWQKANDKTGAASSTLVSREEASRFIFWHFLSPSYHPLTKYLGSWTQEFVALSGLPGAHAHPTLVFYVAPPCSRHLMPSLAGLVPHSDAYNDILRSFTEPFYSRMPNYDVSSPACRPTFFLGSQWQNDPFAGYGSYVSFQVGLERADEDLKVLRSGGGRGATGGNLMGNDRGVWFAGEHTAPLCGLGTTTGAWWSGERAARDVLEVYGMKKDMKKDGIGPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USU2</accession>
    <name>A0A7D5USU2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g001300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542942.1">
        <property type="nucleotide sequence ID" value="XM_014687456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USU2"/>
    <dbReference type="GeneID" id="26244315"/>
    <dbReference type="KEGG" id="mbrn:26244315"/>
    <dbReference type="OrthoDB" id="10452906at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028998932" evidence="2">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="270" mass="29371" checksum="5AF542A0FEDF1D97" modified="2021-02-10" version="1">MKIAVLATVSGLFLAASTLALPATSSAQPEASSEQWQEAFMSIWSCHCTHRGGQDYKKHVKKDMQCMIENTATTVGNFETGEKDSLVEMDKEVEKCKAAAWQRARHSECEPGQYETECYFPIWKVYSTCVGNSPSTSKRGSDCPKNPNSKPEKVKGDKAKPQGANSEEADECPEDPSSKPEEAKSQEANPEEADECPEDPSSKPEEAKSLGDNSKEADECPEDPSSKPEEAKSQGAKTQGATSEEVEPEKAKTQESKPEKAAKTQEAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USZ9</accession>
    <name>A0A7D5USZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trs31</name>
        <name evidence="9" type="ORF">G6M90_00g020040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548539.1">
        <property type="nucleotide sequence ID" value="XM_014693053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USZ9"/>
    <dbReference type="GeneID" id="26237983"/>
    <dbReference type="KEGG" id="mbrn:26237983"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="213" mass="23990" checksum="7AD67766B654BECC" modified="2021-02-10" version="1">MSNIQPAAQGTKETGLRVPSNGKTIYHRPLNRTKTAELSQASFAYLFSEMVTYAQRKVKGIQELEQRLNEQGHPIGLKLLDLLLYREPPRSQLRPLSIISLLHFIKQNVWQHLFGRQADRLEKSNNPDTPDEYMIIDNEPLVNQYISVPREMSQLNCAAFVAGVVEGVCDGADFPARVTAHTVGEGDMWPGKTVFLVKFRSEVVERDGLLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTA8</accession>
    <name>A0A7D5UTA8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HET-E1_1</name>
        <name evidence="2" type="ORF">G6M90_00g020550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548491.1">
        <property type="nucleotide sequence ID" value="XM_014693005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTA8"/>
    <dbReference type="GeneID" id="26237935"/>
    <dbReference type="KEGG" id="mbrn:26237935"/>
    <dbReference type="OrthoDB" id="4935013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="68671" checksum="F4B54183172226A5" modified="2021-02-10" version="1">MRLLKTANYALFEAHDIPVPFPHYAILSHTWTSPKEEITYQDIRKRKSDIENNIYKQKGWSKLTKFCDRAAKDGWDWAWMDNCCIDKTNPADIQEAINAMFRYYQDAGLCYAYLEDVDALAALEDAGLHEDEDPDEIANLNDIACPDSLAYEALHSDFIKARWFSRGWTLQELLAPHYLVFVDREWRRIGSRETWASEIKEASSIEARHLTSFRPTDFQSCSIAMRLSWASRRVTTVQEDETYSLLGLFGVSLPLIYGEGRWRAFNRLQRELITVYNDDSIFAWTVEQPTVSGQSNNSGWGILASSSEQFRGASEIESLGHFSSSFSMTNRGLEMRAKLIRHKGDPSLCLLRLNCGVQPGGYVGIYLRHVYDAYDRVHVQELCDMDNLDPNDWEGERGNSPILIRVSSSADTLTRSSIFALEYPAHIRIGTKYFVDFSPSMIDSRMQVFDQDSQSTLLPDLTEDELFTEPNRTIFINIELLTEGFKWELDVIINLTENGFPSVGVLGRASEPWERLGDPLGLASQRYDALANYLHFRVPSEPTYPTLAVNEINNCAVGVSLLPRPLHGRLLNQPPEMAKFLSLREYVLRIKIRRHIPLSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU47</accession>
    <name>A0A7D5UU47_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase SAT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SAT3_1</name>
        <name evidence="5" type="ORF">G6M90_00g039690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547322.1">
        <property type="nucleotide sequence ID" value="XM_014691836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU47"/>
    <dbReference type="GeneID" id="26239885"/>
    <dbReference type="KEGG" id="mbrn:26239885"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="295" mass="31050" checksum="7AA3747F7EF00934" modified="2021-02-10" version="1">MSSQPDNASLSALDLFNVDGLVAFITGAGTGIGLMFAKALIKNGAAKVYIAGRRLEVLEKAASSIGPNAIPVQCDVTSKESLREAAKLVEKDSGYLNILICNSGITGPSAPAVSSETTLEEWADGNFARDVNEYVDTFAVNTVAVWYTTMAFLKLLGRGNEKKNVTQQSQVVITSSIAGFNKTSTAGWAYGQSKTAAILASKQLATALPRWNIRANCIAPGIFPSEMTDSVIQQYRGEAGGYGVVPTTMIPMGRLGEEADMAGTILYLASKAGSYCNGVVVVLDGGRLNTFPSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUH9</accession>
    <name>A0A7D5UUH9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metal tolerance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MTP3_0</name>
        <name evidence="11" type="ORF">G6M90_00g035950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986295.1">
        <property type="nucleotide sequence ID" value="XM_066130174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUH9"/>
    <dbReference type="GeneID" id="26239553"/>
    <dbReference type="KEGG" id="mbrn:26239553"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF13">
        <property type="entry name" value="CATION EFFLUX PROTEIN CYTOPLASMIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="154"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="360"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="461" mass="51795" checksum="6D1854134CCD2E0B" modified="2021-02-10" version="1">MSNPSSATPAAKPGEAHDVPHQPSDEPATNPPSELSNGSREEPEKTHQQYSEKAAPTRNPGPPAIQNTDNVVSGGDSIEPVPVLIASETFRSAKLEDIDKEVASRYTKKNRKKLKSFYSNQNELIDQYLGVGDEEQLAAEEEVRMRPKIRFAVYASFFVNLCLFIIQLYAAISTGSLSLFATAADAFMDLVSSCVMLITSKLARRPSIYKFPVGRSRIEPIGIIVFCALMATVAIQLLIESARSLAGGHRDASPLQVVPLSLVGVAIFMKSSMMVYCFFYRRFPSVHVFFIDHRNDIVVNIFGLVMSIVGDHFVWYLDPIGAICIAFLILFSWAYNAFEQIWLLAGKGAPKEYISRLIYVALTHSGHILKVDTCRAYHAGQKYYVEVDIIMSQDMPLKISHDVSQSLQRKLEGLADVERAFVHVDYEHDHSVHEEHKPLYEDAQLKTLREYFRSFIRKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUI2</accession>
    <name>A0A7D5UUI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545123.1">
        <property type="nucleotide sequence ID" value="XM_014689637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUI2"/>
    <dbReference type="GeneID" id="26242464"/>
    <dbReference type="KEGG" id="mbrn:26242464"/>
    <dbReference type="OrthoDB" id="5231339at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11151" checksum="57A3BAA6AFD4F439" modified="2021-02-10" version="1">MPPFKKWEITAELDLCMAIIYTGGSVGSYKWPEIHELMVKFGHDFTKDAISQHFTKAILKSFKDRHGLPAGKLESMTPTKTKRKAAGDVEESPSKRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUV4</accession>
    <name>A0A7D5UUV4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">brc1</name>
        <name evidence="3" type="ORF">G6M90_00g038710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547227.1">
        <property type="nucleotide sequence ID" value="XM_014691741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUV4"/>
    <dbReference type="GeneID" id="26239790"/>
    <dbReference type="KEGG" id="mbrn:26239790"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18439">
        <property type="entry name" value="BRCT_BRC1_like_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="3"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="101"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="337"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="729"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="852" mass="94877" checksum="F51B1A8239CC9B23" modified="2021-02-10" version="1">MAARSGVFNECAVAFVPSNELTPKLIGDLSRIIEDNGGTICEPRRNGSIPIEKATHIVSNTINFEQYVESQAIMIPVVSEHWISTSIMRRKAAQVRPFSPDPRMIFAEIVVTCADLPLMDKESIIGATMALGGQESKDVTRLTTHICALSMDAPKVMGALEKGFKGKIVLPHWFDACFKLGKRIDEEPYLLPDPEVMKKSSDDAISIPANKNLVGATSVSPEFLPIAADSQGARPPVTVFQDRAVMLAADLHITARLAKAIGDIVLDGGGKLVRNVDDCDMYICQYRDGDEYIHAAQSCKEVGSLSWLYSLIVNNQWQNPLHRLLHYPVPLNGIPGFKDLRITISNYGGEARIYLENLIKACGAEFTKTMKADNTHLITARDSSEKCKAAPEWGVAVINHLWIEESYAKCELRAINISKYNHFPPRTNLGEIIGQTFLDESRIRDLFYPGGEEKVSPSARRKRKILEAAADNAYHRGPAEGVVIGRDKDFDVMRDDEEDQNPSSLKSKKSTAVETPARSRRAHSGKENDTPPAMSTGSRSAKAKARDILQCIAPDIALYEKEKKRHSKAGAPWGGKRAANLAEKEKDSKTATSPKHKQEDEDEDTKRPSKKQRPSLPDVHMRLVVTGYTGWVGDSKKEDHDRRKMRALGILIVQEGQACDYLVAPQVVRTVKFLYALARGAVVLSSDFIDKVLETGDVPDVDDFILQDQEAERKYKFKIERSMARAKANRGRLLQGIPIYCTEGVRKGPESYRSIAEANGAIFKLYRARSGTTIKPTTAEEDGFAKPEPVYLLSGNSPDEKQMWVRFRTMAEKGNMESRIVDPDWLLDVAMAQEVRFDENFLIEKRNQDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVJ1</accession>
    <name>A0A7D5UVJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine phosphoribosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">XPT1</name>
        <name evidence="3" type="ORF">G6M90_00g040180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547367.1">
        <property type="nucleotide sequence ID" value="XM_014691881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVJ1"/>
    <dbReference type="GeneID" id="26239930"/>
    <dbReference type="KEGG" id="mbrn:26239930"/>
    <dbReference type="OrthoDB" id="9973266at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
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    </dbReference>
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        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="206" mass="23186" checksum="FD174B12DA487610" modified="2021-02-10" version="1">MSDVEKIYVTYNDVHKLCQKSADRLLGEFQPQLMIAIGGGGYIPARILRSFLKRPGSPNIPIQAIGLSLYESLGEDTEVEQIGKKVTRTQWLDLTALGQMENLVGKRILIVDEVDDTRTTLEYAVKELEKDVEAARQRMGGDQPKTEFCIFVLHNKDKPKKGVLPHDMIATRYEAAVTVGDAWINYPWEAIDIDEHDRNAETKSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVW1</accession>
    <name>A0A7D5UVW1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secondary metabolism regulator LAE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LAE1_1</name>
        <name evidence="3" type="ORF">G6M90_00g040640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986412.1">
        <property type="nucleotide sequence ID" value="XM_066130272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVW1"/>
    <dbReference type="GeneID" id="26239975"/>
    <dbReference type="KEGG" id="mbrn:26239975"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="43734" checksum="669B16CB92B87EB3" modified="2021-02-10" version="1">MVFSRSRERTKSVGLTDLADSKPVDDDDAKVEAPIDLQEAPPSAEAAAEASSSSSPGPSAGVRATQTPVIEPATESDDEFDLDSGLQGDDTTASLASSIYTSFAYERGRRYQTFGDGRYPIPNDDLEQNREDMKHAMLMMLTEGKPFFSPVGTHPQKILDIGTGTGIWAIEVGDRYPSAHVCGIDLTPIQPEWVPANVSFLVDDCTLDWIERDVDLAHFRFMVMILKDIPTVLGHAYESLRPGGWVELQELHGVPLCDDGTMPDEDPVKSLYDTAGAAYKKFGMSTTLPAQLEPYLREAGFENVHCRVMKVPIGTWAKGKIMRAIGLYQKMAILDFIPTLAGRPFQALQISEADAEIRVALARKGLEDTSTHRYFNYYFWYAQKPGSSRREEHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWF6</accession>
    <name>A0A7D5UWF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="3">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLD_2</name>
        <name evidence="9" type="ORF">G6M90_00g053380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540463.1">
        <property type="nucleotide sequence ID" value="XM_014684977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWF6"/>
    <dbReference type="GeneID" id="26246825"/>
    <dbReference type="KEGG" id="mbrn:26246825"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF76">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="8">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="560" mass="64033" checksum="BA0547ABA41AB3BF" modified="2021-02-10" version="1">MAPAMSHRNRLWSRSEIQGLIADGRKIIIFRGQVLKADAWLPYHPGGDKSILHMVGRDATDEIAALHSAEAQAQMQKYVIGRVHGTWENFLPPIQGGIFRLPVSKNDGDEALSAETDASSSGTSTPSSTVFDIGQAGDQVRLRRTGNDTPLSTASSLLSSETEPRQFGHVETSTAHAISTDVSKYPLLDKMSQDEVVSKYRQLDEKLRSKGLYQCEYSYYAVEFARYSILFALFLTFLHYSYYTLSSICLGLFWHLLAFAAHDAGHLSITHGFHTDSCVGIFIADFLGGLSVGWWKRNHNVHHIVTNSPEHDPDIQHMPFFAISSRFFSSLRSTYYDRVMKFDAASQFFIKHQHYLYYPILLMGRFNLYRLAWLYLLDPAQAPRKGPAWWHRHLEMAGQAFFWYWFGYRTLYLSIPTWSSRITFLLISHMVTAPLHVQLTLSHFAMSSADLGVHESFAQKMARTTMDVDCPPWLDFIHGGLQFQVVHHLFPRLPRHNLRRAQKYVKEFCDDVGIPYVIFSFTRGNKEVISRLAEVAEQLRVLEECRKVAAKDLIQGHHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX86</accession>
    <name>A0A7D5UX86_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">UBP2</name>
        <name evidence="9" type="ORF">G6M90_00g044210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547755.1">
        <property type="nucleotide sequence ID" value="XM_014692269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240318"/>
    <dbReference type="KEGG" id="mbrn:26240318"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02666">
        <property type="entry name" value="Peptidase_C19J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="602"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1218"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1257"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="803"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1269"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142925" checksum="4DF3D48B22A41E2B" modified="2021-02-10" version="1">MAGHFDLSSQAQEASPYATLPGTSQAGFVPHNMTPMKSNLAPGREIAGCNPSRWVYELLNNDFTVCDLFERARHAKLESTYTWDHAHKLVMNGNQSFSTASSRVLSSICLDCHFHFVFKMTWDEAHSDGLCHQNQSSWPLRDDQFPWHHLVWVGSSSDPDVAQDNTKYCPLLAREYFVCSAPPCTFQLTLEISEPRMPQSWVELLLDREAICQQLQAAKEQEPGRYEAATDEWAYQATLNLNTYLKNLLESTPEDARSISKRNKRFAVLFGPRCFAMFRELEFTEKVELRDGVDEGSFTPSPPPPAGGPSETTEIGTYRSYLEDVRAEVQCLIHKAGQAAEKPTIITPVLHADLGCNEVPNAAANALVNVERYKLIGVLPNQTREAVVNAYKRQWDLLPSRRRALVDSIMGIANDSGDELLSDYAITQSSVFDNQTHRPATNDDDGLVPQALNFLGLQPPNNYSADSLIQAFRQKLARDPADATTARSMLLLIAQNSNDDMYQAQLLMEADAKMSLETSRSILELKAVEVPWETTYEAAKNKIEASKSKEATQVFLDALEAIADHTYSPALKQAAMELRQENGIYGVKAKSEDEPVNYALPVGLHNIGNTCYLNSLLQYLFTVKPVREIVLNYDNVKLALDDESIKARLLGGNKMQMDRGEAVVAQAFAKELSELFQNLKASKRSATKPSQRLANAVLLSTHTLLHNTKQSSEPPIGPRPPPLPARPSPAPPTQSVEDVEMTNGSVANALEPSEMASNSSSRTLIDQEDARSDHSYERVETVHVSGQADGDTEVLSKTDDPMDQSSKSPPQPTKETITTEATNDAQGSFQDVDMADAEIETVDQKVLNALEHQKRSSGTDQQDVEEVMGSIINRLQAAIQPTSVDEKTGIQLEKIMETFFVTTVNYTKKFDEREYQSEISFDRSITAFPAPDGPCSLYDALGRNFDQQILEESKLSRYTAIKTLPPVLHVLIQRSQSMGSKNGNAVVIPETLYLDRYMDAPHTSPVFQRRVEDWALSDRISDLKVQISKVDSNPTYTSYLEKYAAGVLETEVADGTANAESAVGEAPEIVAAPEENWDFDGPVDEDFLLVTTSTSTGSEQPIPHEPKPLNIRASDAAIRQMMEAELQKREETLKEHQESLKGTPYRLHAVICHRGQLMSGHYWVWIHDFEENTWRWYNDADVKENKNTAEVLETLSTSGEPYFLCYVRDEDKAEYVNIPKRQPPTPPLELQESPASKMVTDKDGDIDAVAEVVAPVIEGIEPPGDETDPGYKKGNDDPQRMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXV1</accession>
    <name>A0A7D5UXV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Imitation switch two complex protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ITC1</name>
        <name evidence="8" type="ORF">G6M90_00g057000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544286.1">
        <property type="nucleotide sequence ID" value="XM_014688800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXV1"/>
    <dbReference type="GeneID" id="26242698"/>
    <dbReference type="KEGG" id="mbrn:26242698"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="367"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="927"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1010" mass="116908" checksum="31FE33CD4070384A" modified="2021-02-10" version="1">MVLYKRKPVQFLPPADIQDENAEVWHIPQTGELFQNYEDYLSRMDFYKQRRFNDQITGHSGLTFFEAFNSELTGGREVEASFPEALKGPILRKVQFQTISRLDNLVDLIYEEFKHDYYPGEEVTVTLDGGDRIHGLVRDKTTYGPRILPDGSRTLPVTRYLVNIKDSDEETNVTNEHICRDRGVFTKAMLRSFIKKTVIREAWTGAPWLVKHDYANMYHIDTRVPPQLRHDTKLLERKQLQAQKRGITNELNGVSNAGPMRLPELKPATKHQKGKQSQFGIKGLKWPLNEPVNGVDGLIQHEQPRAPIREPTPPPPPPPTKYPIEDLSLPPKEGSVRPRLKFMCHDPPVKIEPEIDESRPFFDKIDMATVGAFLETWDTLNVYCEIFKLDSFTFDDFVETMSVASEQLKVQLFDEIHCSVLKVLVDSEREGGKVRINLPELEDEYSDEEEGEEEDDEADEGQEAAAEPEEKPKGRATRSSLAKLEAERLAAEAAAAEKEEIRAEQESRNRAEELMREFDWIDHLRKRNFSNGGWERIMVGLLHQLSKDDRYKESCEELLEQLVPADSNPTQEAIRQSYAELDVNCRVKALQIICLLTMQTKAVRGYMEDCSETMTKYRKDRIEWQRQKKQAIEDVRQLHEQRRELVPDPDPYEQVDANVVKEEEDAKMADADESQIDKENAEEGNDEPSQPKGKRRGRAPADKKKKKDAELEKEKKEKEKAKEKEKEKGAEKEKEKTRKEMIKLTSQQQKQYNKILKEIQKKEDIIKECEDEVAVIENDLREADCPRTRVLGKDRFWNRYYWFERNGMPYGGLPTSSTAAAEYANGCIWVQGPDDMEREGYIDGSPDLPDECKAKFRMTVSERKTREENGTSVFTARQWGYISEPEDLHALIKWLDPRGFNELKLRKELVNYKEKIAKHMENRKKYLAGEEDKDKKDEAVTKRSSSRIRDKTPEPPTYRCLQWENTMALEELGHIHSDPPPPPRARKQTKKREAQTEAAGRGAAKSRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY04</accession>
    <name>A0A7D5UY04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541031.2">
        <property type="nucleotide sequence ID" value="XM_014685545.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY04"/>
    <dbReference type="GeneID" id="26246337"/>
    <dbReference type="KEGG" id="mbrn:26246337"/>
    <dbReference type="OrthoDB" id="4939997at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="68295" checksum="C7CE56C5D4362679" modified="2021-02-10" version="1">MINPGLAESEALALGGVHWRQIRRFGLMSTAEGGRVAQIQWIDNPEYDRDLYENSQYAARCVVDNDVPPDLDDDWSEDEMDSLDVTREDTDSDESDGEGNDLYPRYRSAATHVSGPAMQALFGRFPPTFTQYPPRDDIPGPSGVGAAASSEDDVIRDAVMRDLERFADLTPEQLRQLYPDYDEMLQELLDNLDRDTCSPPKRPRTQLRARAGQSKNICCQSLYKIRGLVIDQTRQNRKNSATAKSAGITLDELKRLRAGEFDGLNCAAIVKKLEEGVFGPKDGDDGSTGASPAGNQQDCKRARKIVTPKSRSKGPKGKAPPAPAKVVFYGDFLWPAEAKTAGGFLPPRTRPPGPTYEVEGGPTPDPATVVDWPSEVLQTRLIFGPAAKDAAGKASHATDGFHGVVYAVHATPNMLVSGLDSIAVGGIRWSQVLGWVQVPLNYTLPEHDAQERANIQQHFERAFKAKNDLFPGSNLFQKNDDYEHKFDELASTGEIPNFDLPQSLEEFMDRNGQAVGWRGGFPLFNPPGRVTGESSTAAKAAKAVAPPHEPGFWEKVGHFMESHILAIALLPAVVVANLIPGVGELADAAEVAALSTEAVEGIELTELSSEGASELTPLLRSVAKLKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY28</accession>
    <name>A0A7D5UY28_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 1 regulatory subunit 3D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PPP1R3D</name>
        <name evidence="3" type="ORF">G6M90_00g055980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544191.1">
        <property type="nucleotide sequence ID" value="XM_014688705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY28"/>
    <dbReference type="GeneID" id="26242603"/>
    <dbReference type="KEGG" id="mbrn:26242603"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="130"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="350" mass="38709" checksum="AB7E66A12DF700E7" modified="2021-02-10" version="1">MPYTHPISQLTLDTKEVIAAQGHSGHSNYAARREPILDEPTCSGVRPLLASSATNAKTGAKKKAVRFKDELEDVRLFRKLDQPRAVSGLPPSTRCLPGKRLTATLQHASSVFVPSTSGGDSTLRCSASWRSPKSNVYLEEVRLLGDATAVVGVVNVKNLAFEKHVTCRFTLDNWTTQSEVAADYLKSIASPDVDEDRDSFGFSIPILDFSRLGRNRLEFCIRYRVIGLEFWDNNNCTDFMVSFEVERHDDSVKPLATSTDSPEETHQDTRRAREGTLEIDGSSDITLGYNFAEPVQSGALRRQYHLSRTPSTIPRPDNKKRDSVVAVMRTGPSVGGARAIRRETGPSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY53</accession>
    <name>A0A7D5UY53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">pH-response regulator protein palI/RIM9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RIM9</name>
        <name evidence="19" type="ORF">G6M90_00g066600</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539317.2">
        <property type="nucleotide sequence ID" value="XM_014683831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY53"/>
    <dbReference type="GeneID" id="26247887"/>
    <dbReference type="KEGG" id="mbrn:26247887"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000862">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="453"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI69757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="798" mass="87539" checksum="934EA84E884FAD62" modified="2021-02-10" version="1">MAKLGPDQYNPETRSFQCDWESCHKSFRRQSDLKRHLYTHTNERPYVCSTPGCGKGFIQRSALTVHVRTHTGEKPYQCEFTECGKRFSDSSSFSRHRRVHTSKQSYTDGSNNSLKSPCVRTPMARYPRSLPRDHHPSNAFDACTLILDSGESSSMTDHKMNFHVQSVLTRSSLVSSSQMLSSPAFDDYGGYLYPYGQIQQKSNLQNTPTEPPQYHAQKARMQMFHHPSSMSQQIYCVDGEDNAEMAIMNTSVPLIYPSPRQLAGLPAMDVPTVTEGTYLSILLFAAFLLLLLSVLSTPITKFVALGSFHDVKYGVFGYCLGDKCTNIAVGYPRGGALTDGTQTFDSPSSVRYTLSTALFIHPIAAILTLVVLCLTVSSHSHGASHSLKYLTILFILTSITFVACLASLIIDMLVFSTHLSWGTYIVLVATIILAISDFGSFIRLRTIIARKSHQQRTVHNENTSGRDYDNRDSEAKPAPVVVSHPMVPTIGGGGSRDEHPVFVTSHSRKKNDSPTGERAFPAQRSAGDKLEKAMHSNITDAGSAVATGKSTQPEARVHYGNTSNECGTSYEDCGREMKSYNLSLGREKPGRRGECGPPTRTFELQGPSPFPPQGLSDMRPGQNERKPSSGDRTLSGNPRLSQPALDRKSTGCRGDLVVDGNGVPRAEATPLGRQISDGLQAPEMNAIPPVPPAANIYELYGQFPNGDVEVVASVGWQQGPSMIASRRATFLSDENQYSIAKLPQYIPPRIQWDENSGRVASRAASPAGHDSVRSGSYSGSLDFLQDFLHPVFSGWISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY78</accession>
    <name>A0A7D5UY78_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g054950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540910.1">
        <property type="nucleotide sequence ID" value="XM_014685424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY78"/>
    <dbReference type="GeneID" id="26246216"/>
    <dbReference type="KEGG" id="mbrn:26246216"/>
    <dbReference type="OrthoDB" id="4924881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028820358" evidence="2">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="469" mass="50183" checksum="61D77CBCB5803B4F" modified="2021-02-10" version="1">MIFSMTPQVFSVLCLAVVSVAGQWTGNYNTTPVADNPIAPPGCQLKSLQGLDITAQTTVYKCVCTGGQVFPSCNWLLSPRHQLYNSVRNATCKCAAAKLTGGDPRSLNTYGRLPNNMGFDKPGVVRTCICDPVAGKGDDSTDKLVETAGSCWCPADRFLWQTSLSDAKESQAVPEMPPSVGEQSTGKQTEPSEAKESQGVPETPSSVDKQSTTQQPGEQQSATASIDECRVDPSVEPSTTQQPGEKQPAEKQPATGSVQWTGNYNTTGAVLSDNPPRGCELESRLPRTILAPCVCTGGKVIASCNWQSIHGSYNTVRDANCKCQRAPAGSTWQYAKDLVAYGLDSNGQNLPGAVRGCGCDPAPGKGDNKPDESGLVVPGPNCLCPTRNLEEYSGLSEAEESQQPGEQQVPTGSFQRCRDDLNKGKLRQNILCKQLMEVKPKELPQRMQSVLPNCSISSLTEICKDIPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYH3</accession>
    <name>A0A7D5UYH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g068330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540588.2">
        <property type="nucleotide sequence ID" value="XM_014685102.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYH3"/>
    <dbReference type="GeneID" id="26246695"/>
    <dbReference type="KEGG" id="mbrn:26246695"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="408" mass="45008" checksum="B26B2739FF897720" modified="2021-02-10" version="1">MSVNSLNSTLVHMMESGEFSDLKFVCQGEEFQVHKAIVCGKSPVIKAAIQRGFKESHTNVIVLDSFQCSTVKRLVQFIYTGDYDDPETPQADGNACSGNTDKADEGVLPNDQLQHSASDEGSPIPFSKGEFKPSLPPPSTPSASLLEHIRVNSTGDYYRIDELVTLANAKITHLLRSNKKDQSWVPSLPLAIEAAVRSTGDGELLDILASATAANISTVTELDQFESIRVMTGFSMKVLRSCAQEIQTLEKAVEESRRTIELQQAKEQQSKCEISRLCRALRIQMRVFSVATSAAARISIEHNIRHMHAPGYERDSKASPRTFVEFHDGLWPAQLGLHKKHAMRLRSFKVSFEVQGMRCPGKAKSGRSSKVANRQYVGDNRTASGYTVSCEPLDAGNGADKIRNCSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYK3</accession>
    <name>A0A7D5UYK3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540983.1">
        <property type="nucleotide sequence ID" value="XM_014685497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYK3"/>
    <dbReference type="GeneID" id="26246289"/>
    <dbReference type="KEGG" id="mbrn:26246289"/>
    <dbReference type="OrthoDB" id="4857897at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="29802" checksum="DA97C4F66EC301E8" modified="2021-02-10" version="1">MSEARPHRKAFNPLFRRPQTVQAGNMEWRPYPYPTDKSPMEGTTAQHEEEWLHAAYTDPIFTHPIGYRDITEAIKLELLQKTFWPSLVSWVEARQEVLPSGEILGGWSRADMYGMMDWYRLCFNMTSRYEDAVAAHEDGIWRTVILTSPWWDWPEFAYLYVKTIRDDKGVPQRDANGRVMREMRDPYDDKLEDEFMDIWERVANTRPLRKHANGQVFLPCDRPSVSRTASTGAAMAAKANGNGLGSTGPSRTATPQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYN9</accession>
    <name>A0A7D5UYN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPB10</name>
        <name evidence="8" type="ORF">G6M90_00g058910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544465.1">
        <property type="nucleotide sequence ID" value="XM_014688979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYN9"/>
    <dbReference type="GeneID" id="26242877"/>
    <dbReference type="KEGG" id="mbrn:26242877"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="79" mass="9288" checksum="8DF174C4630D3F10" modified="2021-02-10" version="1">MIIPIRCFSCGKVTGDLWERYLQLIADPRKTDGDAMDELGLKRYCCRRMIMTHVDLIEKLLKYTPDGRNEKKQRLNELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYR4</accession>
    <name>A0A7D5UYR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sed1_1</name>
        <name evidence="14" type="ORF">G6M90_00g065600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986805.1">
        <property type="nucleotide sequence ID" value="XM_066130806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYR4"/>
    <dbReference type="GeneID" id="26247023"/>
    <dbReference type="KEGG" id="mbrn:26247023"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
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</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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</entry>
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="436" mass="47886" checksum="88CFD56A4CBC832C" modified="2021-02-10" version="1">MAFLEDPRLRQRWNQITHDAETVTENAAAGIFTFQQNYINPCLASIADSIEQCTTVCLGDPEERLRRRRERQRARESAEFSFDFYDDWYEEEQSGGGLLGSWGGEDWDRLLAGTGSARRHGGETNEQPRRKRGMSYGTRGMRRKASQNDATIIPSTQPIGFLSKLPWKMGGTLRYKPSAADLQDHPGKHGAGESAPLLGGDDDSDYGEVLRMPRQRSGTTGSGGTSDSYRSRGDLFPSDGEGEEDAVPLDDDVTYDMVKRDDRSSAKTRSSKGKRPAGKLAASSRTVSRSTLGSTASSESREYATTAPPTPGVAHIPPMEDLQAEETRLQRQEHDEQARRKMAASQLASGRGLGADEEVHDIEEAKMLEVAMNEIHEPQDKVTSLQDRDGRESPPPPPPPTAASRDQPRGSGGDDPYQSSSRSTSAFHAARLPRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V053</accession>
    <name>A0A7D5V053_9HYPO</name>
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        <submittedName>
            <fullName evidence="5">Homocitrate synthase</fullName>
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    </protein>
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        <lineage>
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            <taxon>Dikarya</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="108"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="41674" checksum="BD2D9C5692C05643" modified="2021-02-10" version="1">MATADNPISHHTSHTMGNGASSSNNGAHGDGATSSANGRNQDDVLDAPLTTPVADLYKCNMDETEADQRPLTGISHSSPISCNILDSKAGTIMSNATLVDSSVNLASFSIIDSTLREGEQFSTAHFNTAQKIKIAQGLDDFGVDYIELTSPAASEQSRADCEAICKLGLRAKIVCHIRCHMDDARLAIQTGVDGINMFIGTSSLLMKHSHGKDMSYIAAKAQEIIEYVKSNNVEIRFSGEDSFRSDFSDILKLYSLVDRLGVDRVGIADTVGGATPMEVYDKIDALRKVVGCDIETHFHNDTGCAIANALVALEAGATHIDTTVLGIGERNGITPLGGLMACVVPTDRNFISSKYRLEKLDYLEELVAQIVGVEIPFNNVTWSLKNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V098</accession>
    <name>A0A7D5V098_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c oxidase assembly protein COX11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COX11</name>
        <name evidence="8" type="ORF">G6M90_00g072140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545849.1">
        <property type="nucleotide sequence ID" value="XM_014690363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V098"/>
    <dbReference type="GeneID" id="26241882"/>
    <dbReference type="KEGG" id="mbrn:26241882"/>
    <dbReference type="OrthoDB" id="4932996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="271" mass="29655" checksum="528397A7F79E2257" modified="2021-02-10" version="1">MGMLFLPKYSDSAVPIAVRPAQPSSKRIDVEPTRRSSGATVPAGSTVYGADSGSLQQEKPDSGVRLPIFLLSAEQSKLIVFLSSYYTISLILGTVALSYGSVPLYKMICQTTGWGGQPVRAHGGSYDGDISNRLVPITSANRIKVTFNASVSDELPWKFVPQQREVRVLPGETALAFYKATNKGDKDIIGVATYSVTPAQCAPYFSKIQCFCFEEQRLNAGETVDMPVFFYLDPDLLNDLNMKGVETVTLNYTFFKARYDNNGRFKAPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0F4</accession>
    <name>A0A7D5V0F4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g070400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540638.1">
        <property type="nucleotide sequence ID" value="XM_014685152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0F4"/>
    <dbReference type="GeneID" id="26246511"/>
    <dbReference type="KEGG" id="mbrn:26246511"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="146"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="406" mass="45708" checksum="C2B1F2D08516A7FE" modified="2021-02-10" version="1">MDRPNYARYLESVYQNTRWEAARTPHGSINATLRARKTSGEAGPQSVILKHASPFFEDDGNLQPFSLHRQKVEQVMMTLWNEGGLLAEHAASPESWRVPKCIRHDEGTEADLLMTDKRDEASILLLEDLGQVVNLRERIELWAEDGPSPDTKNKVARIGNILGDSLAVMHSRQTSLAIESDPKAAEVLSQSSTDDVVWYLAMEIFPTYLGNTPKADVYYRRLVRDIKNPLYIYPPCLVHGDFNFGNIMLPLREDDSPRPVVIDWEFATRDGRGVNGDVSEFLSILHCRLVSARRRPGQSTLTELVRGLCGGFCEGYRQRAGLKCTMEAEDVNSQLYRSALLLSGRDMINYAQDACAEDEAFDEMMGVGLWYLERAGEDMGEFLEGSNSEELGREDEGLVRSLFMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0X8</accession>
    <name>A0A7D5V0X8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Toxin subunit YenA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yenA2</name>
        <name evidence="5" type="ORF">G6M90_00g069900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540684.1">
        <property type="nucleotide sequence ID" value="XM_014685198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26246557"/>
    <dbReference type="KEGG" id="mbrn:26246557"/>
    <dbReference type="OrthoDB" id="4938011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046839">
        <property type="entry name" value="ABC_toxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041079">
        <property type="entry name" value="Neuraminidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040840">
        <property type="entry name" value="TcA_TcB_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20220">
        <property type="entry name" value="ABC_toxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18413">
        <property type="entry name" value="Neuraminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18276">
        <property type="entry name" value="TcA_TcB_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC toxin N-terminal" evidence="4">
        <location>
            <begin position="1344"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="Neuraminidase-like" evidence="3">
        <location>
            <begin position="1495"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="Tc toxin complex TcA C-terminal TcB-binding" evidence="2">
        <location>
            <begin position="2440"/>
            <end position="2726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1690"/>
            <end position="1714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2882" mass="315602" checksum="9C90FB6F0D3AA7F1" modified="2021-02-10" version="1">MPSELDERRLKEAKKLLQGLVKDSSRLFAALDRTKSISQAIDSVGTGVGSTPESQRRLALLADLDRAAAGNVELASLFWGQSQVRSMSDAARCYGLLLDREGAGVEDFQMRLFAEQPTATIYSLVRAGHLTIQPKTIQTAVVNLLDRAVSSGFNIGRDPVDRLLSKVDALSAGKKKDVEALKSFIQKLQRLQALVRLPQDLDALLKSSFMSAHQIAHTPRHSFVTVIGRHGIPAASAVRIHNHATLVDMRNEQAWTALLASKHDVSLAALARPKAAPPVLAASAVASTTAPSPQVTSYTKIFGDMTIGACDDCSSVSSPAAYFVDLLRMLKNTPSDATKTDSPSLLDKMATRRPDLLTLQLSCVNTNVLVPYIDLANEAMESFIKNVGSLLPPSPVPIQGFNMTDQDTSEVSLSEPQHTDYSVYSNQIAAQAFPLTVFPYSQALDLQRLFFAHLNASLADVMVLFGSASRLLSKTPTTDTLGLAQDVLQSAQAAEYLGLSPADYVAITGASIFSLDFFKAVLDPSMQQDAYNAKIGLLSTAAYWGYEAAGGQTAAQLMLSEVDEKGLPFVKAQLLRRADMTVVDLLDLLRARVLQRQLVLENADGSATFSGELQDLRLRHPTSSNAKAPLTELDCWQLQSYIRLWRRTGWTLQDLDCAIVAFGGGGGTRVTAQTITAMAAVQRISALTGVDVFRLMPMWGPMDTNGDRSLYARLFLKAKSGRPDPVFGPDAQGQYLTAGAGLMANRAPLLAACGLTEEGFATVVAAAKITNDKLDLANLTAVYRIAVFCQLLAVDPVDFASLQAVLDPSQSAFVSPQAALDVIQQLQQLTDAGLSLEQLLFLTGNDAAQRARQSDTELPVQQVAVAASDVMVNIQSRMAALPAVDAHTTTASPADVAAAAAALYDHETAQLAVTFIEMLPGTPITEDSTVYQSVLLPYFSGDAQAAHKVFFEQPDPTGTDEEKAIARENILDARRVFFLQHVIGPLHARAAKDAVLQSITPLFPDVKAAVLGFLVETVQEPGSQEGGHQPASHTLILDVLGGLAASNAAALAKDSSDVFFRPPTADLYRLFVPDTTLTASPLVTLDGNTLLFDKGTDGWTSKPVRLSNGQAYSLRRSDDSGLASCSYLTERSPGRPFALGALMARETVVLAQTVLLLLSRAVHLSTSFELSLDEVQFFQGQSSSGSLFIDWGNIDYQAIQRAKSYRELARRLNGPTVLLDFLKWTQGSSRDGTLASSLVSVTNLSAAQIADYLGQRFAGLSEQQLIEVFAGTAEVARLLDRVAFMNRTGVPGLTLKLLFALATPVPPPTATIDFDNADQLRCLLQSTPASGNGADLATQVNGGLRQHQRDALVNYLVQHPYITSRGITDADGLFEFLLIDVQMGACLQTSRIKQAISTVQVYVRRCILGLEKGEQVASNTVNLDRWAWMEGYRLWEANRKVFLYPENWLDASLRDDKTDVFRALESGILQNDLDSAKIVDLVKGYVYGVDAIADLDVQAYLWKKVEDYTGTFHFFARTRAAPYIYYYRSLDIVPSPSGHGIKMYWQPWSKIDVEVPVHEVGADGKPLPVSGSYLTPALYGERLFLLFPQITLKTDPNPAAKDNTIKTMEDKKPDEIKPTKYWQVQIGWTEYRNGRWTPKQISQAILEVRGAQDTDFPVKGKTLPAANIWAEAQKLPDVASLKFWIRSRPSSSIPSGASSTVAASSPGPRSAPAPSTSILVIEVERWIDAGAGQTPRYQNYPLGRFEMRGSQVILANLSALSGQNDPFLTPWRPTIPTVFAKMSYHMAKATDKPTPGITIGRGASDKEPLLGIVSKLVDSTPKKDVVWTMSFNDSQVRNATGFIQDIITTESTISYVTYPPIASTTTFASDVFQHTLDRDLVSMSTAYDGVDQVYAFLASVPADDAFLAFGKRNGTVHELSTPYALYNWELGAHTVMLLMERLQVNRQYDLALQVAHLVFDPTVDGTSLDRCWLFPPFKELADGTIDSVEDILKRLQPSSGAESEMKTSILDWRTHPFNAHSVARSRPLAYMRRIIINYIEILIASGDVYFRQNTLEALPLAIQRYVEASHIFGSAPVRVPQLAKPTYKSYNDLASTLDDFSNAAFDMELDFPFFSDPASRGTGTGANGAAGLTGILKSTYFCVPANPKLVQLRDLIDDRLFKIRHCQDINGVVRSLALFEPPLDPGLLVRAAASGVDISQLVGNVVGPMPNYRFQYLLQRAFDICAEVKSMGALLLSIQERKDTEALSNLHARQDKVLQGLMIEMKKTAKKEAEASIDALLEVRKSQVARLEYYLALTGTDDHSAPDETQDWEDITQSIEKPTSDDLRMTSHERLEMEKADAAADLNQKATILDIAASIVKIIPDISEEAEPLGVGVSIDSVTKNISEAMLINASVMRFQAQYFSDEGARAARTGALIRQLQERRLEANMAGREIKQTDKQIATARIQVEMCERDMQFQQQQADYARDTEAWLRTKYTSEELYAWMDGVVRDLYHQTYLMAEDLAQKAQAALRFEKGDQSINIVTSPYWDDGRDGMFSGENLYLALKRLEGAYMDQRLHDVEVVKDVSLLQVRPWALLALRETGTAEFDLPEVLFDFDFPGHYCRRITSVSMTVSCVAGPHTGVNATLTLLEHSYRIKPDARNAQDYPRKTPDDRFQTDRVPITSIAVSHGQEDSGVFDLDFRDDRYIPFEGAGAVSRWRLELPTAVKQFDYNSISDVVLQVKYTALQGGAAFRKAASDAAVAFQKTASGLSRTEGMFALLDLKNDFPDEWQRLVSADKTKPSTMPLASLQDRLPFFTRGKSVKAETVSVLVAAGAAVNMTQDITLTASSKIPLQAGTAIGSYQVAVATGQTVTVGDWSLTLSANAMNASVSRILVLFRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V130</accession>
    <name>A0A7D5V130_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g084750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987261.1">
        <property type="nucleotide sequence ID" value="XM_066131254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V130"/>
    <dbReference type="GeneID" id="90968079"/>
    <dbReference type="KEGG" id="mbrn:90968079"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="90" mass="10315" checksum="E845C8C9FFA3FC0E" modified="2021-02-10" version="1">MNSGNDISEEHPLVQEVNRLMWEIQHLIADANQACAQLLELERISAYSTQQIALLMENQLDPIFRELSSRHVALQELILRLEQLTTNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1D2</accession>
    <name>A0A7D5V1D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CPYA_2</name>
        <name evidence="8" type="ORF">G6M90_00g073950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545670.1">
        <property type="nucleotide sequence ID" value="XM_014690184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1D2"/>
    <dbReference type="GeneID" id="26241703"/>
    <dbReference type="KEGG" id="mbrn:26241703"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029037912" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="483" mass="53584" checksum="26E9A51692B3FF55" modified="2021-02-10" version="1">MRFSAAFFLGLVSVTAAFPNPYPDEATDIPPTKESLGKRDGEFSYLISGADVKASQKYGGHLVNYKLRANAVDPSRLGVDTVKQYTGYLDDNSTDKHLFYWFFESRNDPKNDPVILWLTGGPGCSSMSGLFMELGPSHIDKNGSLVRNEYSWNNNASVIFLDQPVNTGFSYSNVPVDTTAAAAKDVYALMTLFFEQFPEYSEQDFHISGESYAGHYIPVFASEILSHPARNINLKSILIGNGLTDPYTQYAYYEPMGCGGGGYKPVLSNYTCQTMEYALPKCQAAIKACYNGEDAACVNAGDRCNTPFLGAFASTGLNIYDIRKKCVGGDLCYEEMNWIQDWLNRKDVMGALGVEVANFKTCNDHVNAAFQQAGDWFLPIQKHVPTLLEKIPVLIYAGDVDFICNWLGNEAWTKALPWPGQTDFNDASMVELTASSGKAYGSLRHARGFAFLRVYKAGHMVPYDQPEGALDFVNRWVRGEWTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1N6</accession>
    <name>A0A7D5V1N6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g085050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987383.1">
        <property type="nucleotide sequence ID" value="XM_066131265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1N6"/>
    <dbReference type="GeneID" id="90968083"/>
    <dbReference type="KEGG" id="mbrn:90968083"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="47" mass="5124" checksum="641F4321B6DC8D65" modified="2021-02-10" version="1">MLGVASRGAGLFDIPPAPPAFGEDERVWNRTMQVAREINVTCEVHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1Y5</accession>
    <name>A0A7D5V1Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541842.1">
        <property type="nucleotide sequence ID" value="XM_014686356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1Y5"/>
    <dbReference type="GeneID" id="26245310"/>
    <dbReference type="KEGG" id="mbrn:26245310"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24571" checksum="E605284D8E9BAF7A" modified="2021-02-10" version="1">MANKVFTTTLGISLLFLASGCLELGFSLVVRNMMSNRPESGQEAVRNLLYQMFPLTAGIANGAATLATFAFTLLGLMSPMRSWLKAGGYLITMCGLFTLCLGVYLWIMTLRLKDGFFPTYLELEPGVQSLVQQSFQCCGYYNATTPAFVTDPTCPSPAAAALLRGCGTAISSFSNTFIDNIFTALFGIVGLDAILILSIACLLKERKERERYRHIDEKSGFRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1Z4</accession>
    <name>A0A7D5V1Z4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KLTH0A01078p-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g100950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546252.1">
        <property type="nucleotide sequence ID" value="XM_014690766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1Z4"/>
    <dbReference type="GeneID" id="26240675"/>
    <dbReference type="KEGG" id="mbrn:26240675"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9405" checksum="ED16AB99DD08EB41" modified="2021-02-10" version="1">MKPVVSAMHAWSCTVISVFAILILSVLAGLYRTGHEEFVGGVGDPSPVEGKAVAGTIFTAVIVYAAFLVFCGFQGLLHVRENRRGAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2F5</accession>
    <name>A0A7D5V2F5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AIH_1</name>
        <name evidence="2" type="ORF">G6M90_00g090040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541662.1">
        <property type="nucleotide sequence ID" value="XM_014686176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2F5"/>
    <dbReference type="GeneID" id="26245525"/>
    <dbReference type="KEGG" id="mbrn:26245525"/>
    <dbReference type="OrthoDB" id="544103at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377:SF0">
        <property type="entry name" value="AGMATINE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="371" mass="40240" checksum="01B36E67165DE70E" modified="2021-02-10" version="1">MVPSRGISVCRPAEWAKHARTILAWPSPKAAPYKDDDAALRRATDDVSSIAEAVARFEPVSILVDRECLPQAEKRFRSTHSHGIHVHALARGGLDVWMRDMAPTFTIETNNTSRRELRGVAFNFNGWGNRFPSEACSSFAKAYLADAGIRPVSSCITAEGGALETDGEGTLLASESSLVNDNRNPGRTRSHIEAELRRTLGVTKFIWIPGLEDGDSTDFHVDAYALFARPGVVVVSAPSETEEASRWTDAYAEAREVLASATDARGRKLEIVEIQEPRVEKVVPGGDLAAVEHGEGHRPVHSYVNFLIVNGGVVLPQFGDGMADRRAAETARRVFGEEREVVPVLIRELPLLGGGIHCASQEVPCVDGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2M6</accession>
    <name>A0A7D5V2M6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein-arginine deiminase type-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PADI1_1</name>
        <name evidence="3" type="ORF">G6M90_00g093280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987609.1">
        <property type="nucleotide sequence ID" value="XM_066131437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2M6"/>
    <dbReference type="GeneID" id="90968128"/>
    <dbReference type="KEGG" id="mbrn:90968128"/>
    <dbReference type="OrthoDB" id="5102063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004303">
        <property type="entry name" value="PAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013530">
        <property type="entry name" value="PAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036556">
        <property type="entry name" value="PAD_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837">
        <property type="entry name" value="PEPTIDYLARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837:SF8">
        <property type="entry name" value="PROTEIN-ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03068">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110083">
        <property type="entry name" value="Peptidylarginine deiminase Pad4, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-arginine deiminase C-terminal" evidence="2">
        <location>
            <begin position="312"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="510" mass="55695" checksum="671DF39C4619F17B" modified="2021-02-10" version="1">MAKLAYIQDIVLGCVLLGDLPLSTFYRVLGCPPGKRAEAPDPISHDLKNDGAVNHPEDEPLATPHQPSTPVPATIGSFRVTILADSNRDGKVDVTGNTDLAGKETWTAESGALFLANIVDTDQRCSSQITGSCASKLGDIFPKTSLPKSPRLDPELAAKKRNRKEKSDSEWLKVLSESDKATYNEYLKKLGEFWDAPKEVNDLRISECHDSSDNVLRNSIYLAPLRTVPNPGLSDSATGSITVFDETAASKVRLFYKAGGQWTFVTSNYTFQALDLKAGLELGIDARDVRRPGGWDGRVTVEFRVKDGEREAKDSVALRVAPVLTQHYGQSAEQLLTASGHPRLAGFVKDLGEMSSTAGLKKPLYIFENSECIFSSGLDIWSQDFFEPGYMSIPGPSGLVSIRIMIRSAQADRPAGRKVFQELRSNIVGALQTPGRGGTLDSLGNLETIPPYTYNGKSYAAGRTVMGSAGRKKPYMMAFLEAQETQAPIELDTSWLKVKHTDEFIQFLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2T8</accession>
    <name>A0A7D5V2T8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein transport protein sec73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sec73</name>
        <name evidence="5" type="ORF">G6M90_00g088810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542234.1">
        <property type="nucleotide sequence ID" value="XM_014686748.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244748"/>
    <dbReference type="KEGG" id="mbrn:26244748"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF405">
        <property type="entry name" value="ARF GUANINE NUCLEOTIDE EXCHANGE FACTOR SYT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="400"/>
            <end position="559"/>
        </location>
    </feature>
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        <location>
            <begin position="685"/>
            <end position="814"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="1193"/>
        </location>
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            <begin position="1219"/>
            <end position="1386"/>
        </location>
    </feature>
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        <location>
            <begin position="880"/>
            <end position="911"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
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        </location>
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            <begin position="1355"/>
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            <begin position="1375"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1386" mass="152446" checksum="8510CFB8834D99D5" modified="2021-02-10" version="1">MASETDIRRHATFNVPRPSNDDGDDDDYEAAPSSSSAAQPVVAGDSYSLSQPDTHQSEPPEHSPEPPTSESERQNKRRPFSILRYRNASDSQLSLRARQQAEAPPPVPRPPAIITTAPTNDIAGPKKVASRMSLAAKFRRSNDIARSGRRDASIDTMHRGNHLADGRDLASSRASDEPVYRRPSTQAAALPNGTSLNALDNRQSESSRSDASSGDHVSRSSPTTTPKKPPSSTPFFKLRKSKKPPEPLFPVAHLQQKNIVKGENLSSASLGTGVTPRPVSSQSATPRASNGDGDEIHITQSSAASALFVRGSGQHSGQSSPTRTNLLRGRSSTMSSMGRDSTDDHLLPPTTRTSTSIGRKSFGDLFGLGRIRQNSELSRQGTLTPATPGSITSKSNSLQLPRDSVILPERQGNESPAKYLARLEGVVSRGVIASALSKGADPFSVAVLRSYMRSFSFFGDPMDMAIRKLLMEAELPKETQQIDRCLQAFANRYHECNPGIYSSPDQAYFIAFSLLILHTDVFNKNNKHKMQKSDYLKNTRGEGIFDDILECFYDNISYTPFIHVEDDLDLTNDRMQNNKSKKKLLSGNGADPAKRAAKEPIDPYTLILDGNLDALRPNLKEAMHLDDHYNYLGTAPSFNLKDLQNTFFKTGVLQIVSPRSRPDAFMSEKTATNPNDAHPGIVDIKVTKVGLLWRKDAKKRKTRSPWQEWGAILTGAQLYFFRNTSWVKNLIHQYEGHLKGGHDGIPIIFKPPLEEFKPDALMSTHAAVALVDTAYKKHKNAFLYVRQGGLDEVLLADSEEERNDWLAKLNYAAAFRTSGIRMRGVVGANFDGQGRRGMRRLDSSDATQLIQTPTGPVSIARGYIDHKMAEDIQTARRDGMQQKICEADKKVEEAQKLLEEQLRNARHLQILAPIQPRTREQLLLAAARMSAQLRWTRMEIWREKCHRDILVQDLADDEVPLLQSALQSDSQSVPSMPQPPLTRLESKSKHQTVDEKSPQTPTENSLSQIPSTVSTGKVIDSPTKTSVPQTPPQSAGKESWHAKSDAKSMRQGSISSIAVAAAQPSTPTPHAKAFQDEDIASSSRTSDTGQDDVDADERDFLKQAGLWEAKSRRASLERTPMSTVTEGNEYSVTTDRDKLERSKIRRSLQRTLRESAGHLSHHRSKRGRDTGPPVVGSVDDGTRETTLSRGTGSFVVHGKKASVINLGTELQTLSQEDKIMSRKQHQSLQQDQQDQPATPLLGSDSLDDDFHSALETPSESNGTSSRRNSVASTSTATARSFRDLHRKYSSAQAARSVSGGRLAIPSDGESEVGPSIRDGRKSPQMASGTRLEDLEAGAYSQVSESVTEDKKLDGEVCESDESCSNDEDTRLEPETLTTQPIQVVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V342</accession>
    <name>A0A7D5V342_9HYPO</name>
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        <submittedName>
            <fullName evidence="6">Salicylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mbtI</name>
        <name evidence="6" type="ORF">G6M90_00g085440</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="454" mass="49436" checksum="D9070363998E39EB" modified="2021-02-10" version="1">MGYACQFRKVVLSRTRSEDDLAIVARLLDASKDSDYFAYERENRWHLGIGSRASLFVDSTGTSVTTMANESICEPVTESIATMARHFVAKYSSNGGRVFGQAGFNYAAFTRGLAFTPGKWPLLSLMVPSVEVTISSDCIAVSGDDAERIEHAVKLIAGGPGAPQAQRQMEVDLDSASGEYIDRVRRGISEIKAGKYKKVILSRAIDLGEEVDMVGTLVRGRRRNTPKRSFSINHAGFQATGFSPELVMALQDGKVVTEPLAGTRAHTGSAAERKALKRNLESDAKEIVEHVISVKEAIEEVRRFSTEGSTVVEDFMTTRVRGHVQHLGSRVTGCLEQGQDGWDAFDMLFPSITASGIPKQDSLDAIARLETRPRELYSGAILMIDDAGLFEASLVLRTVFQNGSQRWVQAGAGVIEMSTPERELLETCEKLATIAPFVVAAETVTPEGCCNGKE</sequence>
</entry>
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    <accession>A0A7D5V3E2</accession>
    <name>A0A7D5V3E2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131443.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90968132"/>
    <dbReference type="KEGG" id="mbrn:90968132"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8201" checksum="351AA549D5A2779C" modified="2021-02-10" version="1">MASSSLPSAATTGLVIVSAIFPALSAVALYLRVVAVRQKASTGSRSDESWLLVSWLTTAPLSIVVWVVAARSGITYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3E6</accession>
    <name>A0A7D5V3E6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987700.1">
        <property type="nucleotide sequence ID" value="XM_066131482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3E6"/>
    <dbReference type="GeneID" id="90968146"/>
    <dbReference type="KEGG" id="mbrn:90968146"/>
    <dbReference type="OrthoDB" id="4757494at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="83" mass="9158" checksum="13549DBA150B471C" modified="2021-02-10" version="1">MADQGSEGYTQEYFDQMHRGSVGKSSTAMTPGSVSTPPAWQHGTNYYGELGTSTASAPYNTSVPHEMPVSRPEREPQEMPERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3H7</accession>
    <name>A0A7D5V3H7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Compactin nonaketide synthase, enoyl reductase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mlcG</name>
        <name evidence="5" type="ORF">G6M90_00g098670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546478.1">
        <property type="nucleotide sequence ID" value="XM_014690992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3H7"/>
    <dbReference type="GeneID" id="26240901"/>
    <dbReference type="KEGG" id="mbrn:26240901"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF3">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="12"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="362" mass="39121" checksum="8A0C0A4EE7F160D4" modified="2021-02-10" version="1">MLPTTQKAVAIASPRSPLIQITVPVHAPSPSEITLRVSYTASTPLDLHRADGGLLITTYPSQSGSGGASGTVVAVGADVHAIQVGDKVSVFAFHGGKEANHQEYITCAAYLASKIPVGVSEQQAATVNVNLCTVFHSLTRDLGLALPWPAEQQPQRGEAVLVWGASSSVGLYAVQVLRHWGYANVLAVSGASHHAHLEDLGARKCFDYRRGVAAVVDEILAEGRTPFILDCIGSLEGSLAPLKRIARRGDRVAVMLPVIVRDASVSEEPVYEMDVAKVGGWEGGVEVRGVRTHFYLENEFFKEHLQPEIVPTLLAQGIVQPNRYREIEGKNMVERAQKALDELRNRSVSGERLVWRVSDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3M5</accession>
    <name>A0A7D5V3M5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g104120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541407.1">
        <property type="nucleotide sequence ID" value="XM_014685921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3M5"/>
    <dbReference type="GeneID" id="26245657"/>
    <dbReference type="KEGG" id="mbrn:26245657"/>
    <dbReference type="OrthoDB" id="5151869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="345" mass="40937" checksum="62318C5C50416ACB" modified="2021-02-10" version="1">MAPETRASRRRADASALHPSVEAASHHMSTASSGDNLSENPEPKSISHDADRHPIAQTETEAIGVRVYVSGIEMAIPQTYDPDTYHPDRRMPWTPEPEPYSPESYTAWGRKHFGEEWYRLRQTMIEERNIFREYDPVYHQRQRTLRIIEHKIERRPFEPSNRVCDPDWKRLWARLSKEWGIEIVRSPTPEKNSDDSDTDLSGYSTYDPTPEYRTPTPFPDDPWEMLEYNHKRFSWNEEEYEFEKMFLKENLIDSARCQHENEPGDEPAREKRQFMEGFRNSDPLRFRIEQGRFRAHDYQSGWTTEQIEALYNATVSMHEWIKENPAPDEMRPYRCGKFESSTLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V448</accession>
    <name>A0A7D5V448_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DBP3</name>
        <name evidence="17" type="ORF">G6M90_00g113800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539685.1">
        <property type="nucleotide sequence ID" value="XM_014684199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V448"/>
    <dbReference type="GeneID" id="26247516"/>
    <dbReference type="KEGG" id="mbrn:26247516"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="207"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="417"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI74796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="596" mass="65773" checksum="AA791893AA0995BF" modified="2021-02-10" version="1">MAATKHTLAEDESVRPSKKTKIYDGNDASEVRIKKDKKDKKEKKEKKEKKEKKEKKEKKRKSEKSNVVVDDAKARDLEIQRKAEKKAKKDKKERKLKEAQELKDNVSIKAPAEVSSVSEKDEKALSSERASTSGSYVQTISLSNVPQDDVDAFMSTNQIAITDPRGETSSLRPVVEFHHLPSTNLLEKTPSPFANFKAPTPIQAASWPSTLSGRDVVGVAETGSGKTMAFALPCVESVSAIGKKGTKAVIVSPTRELAMQTHTQLASLAALAKLKCVCLFGGSSKDEQRAMVNRGADIIVATPGRLKDFMSDSTVDLSGCQFAVLDEADRMLDKGFEDDIKQILGACLARERRQTLMFTATWPQSVQALASTFMVDPVKITIGSGGKETENGSVELQANTRISQKVEVVDPKDKEFRLLQILKQHQQGKQKNDRILVFCLYKKEATRVENFLSRKGIRVGGIHGDLKQEQRTRSLEAFKTGQTPVLVATDVAARGLDIPEVKLVINVTFPLTIEDYVHRIGRTGRAGKTGEAHTLFTVQDKAHSGSLVNILRGANQPVPDDLLKFGTTVKKKTHDMYGSFFKDVDMTQKATKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4R0</accession>
    <name>A0A7D5V4R0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ada1</name>
        <name evidence="12" type="ORF">G6M90_00g110010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543855.1">
        <property type="nucleotide sequence ID" value="XM_014688369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4R0"/>
    <dbReference type="GeneID" id="26243242"/>
    <dbReference type="KEGG" id="mbrn:26243242"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="953" mass="107903" checksum="A5367B33EE634521" modified="2021-02-10" version="1">MADNAHDSRTRPARCEDTEQDDAYLRNDETVEAIENGDGSFSPMPADEQAGLQDGMLLRDVPKRTTFYDPVAERQMSQMDAKLFYQRSKIDLRSGTAGASSWTPSNPNSPTLASGSRPVTEYGADSLILDQDGVDDTEVSSMPQSFAHNHPATSSGAIPNSRNSQSEVNNTRLAAEGSMAEFPSNTLFDTEPHVTAELSAISQNIQKVLDLRRKYIALSSQGPDDNPRDQSSWDIYPPPPEPAWAQTKGGRTNFPDALSSAQTGHNDHRPSSSWRRKPDLDVGEDFNMNDLLPLPGDDGMAFRLDDSGVYQVFDSDDATLPAIKVPTIREFYMDLESILTISSDGPSKSFAFRRLQYLEAKFNLYALLNEYQETADSKKVPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKMKKYPNEVVLFRDGKHLTLAEVFASINLTAYDLSIDTLDMHAHTDSFHRFDKFNLKYNPIGESRLRTIFLKTDNFIHGRYLAEITKEVISDLESSKYQMVEWRISIYGKSIDEWDKLAAWVVDNKLFSHNVRWLIQIPRLYDVYKASGLMETFEQIVKNVFQPLFEVTKDPSSHPKLHIFLQRVIGFDSVDDESKVERRLFRKFPVPQVWDSKQNPPYSYWIYYLFANVASLNHWRKNRGFNTLVMRPHCGEAGDSEHLAVALLSCHSISHGLLLRKVPLLQYAFYLEQIGIAMSPLSNNALFLAYERNPFHQYFRRGLNVSLSTDDPLQFAFTKEPLIEEYAVAAQIYKLSSVDMCELAKNSVKQSGYEASIKRMWLGHNFEKPGKDGNMMVKTNVPDRREEFRYHTLLQERDVLRRYVAYDGTKEPSSTVTADIAAYRAASRADEPLKLAGIGENTLWAQARATSVGVKSPLNGEASCDSGRGPHAMADLHLSGSDPRLFPGIFTRDHRSESLRSLQQADEWVVDSSGAPGDDDEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6B6</accession>
    <name>A0A7D5V6B6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="6">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NIA1</name>
        <name evidence="17" type="ORF">G6M90_00g106090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="6"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987847.1">
        <property type="nucleotide sequence ID" value="XM_066131698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6B6"/>
    <dbReference type="GeneID" id="26247596"/>
    <dbReference type="KEGG" id="mbrn:26247596"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="659"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="122"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI74239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="971" mass="110480" checksum="0AB5E4A66ABF1281" modified="2021-02-10" version="1">MDTSCWKVKVQPHPGSSVHDIATEPNWGVGHEHRVGYRNSSNRLPGLTDDGDYHAEIEQAQLARKELEEEITHGTLINFRQLIEHQPDFHLRHPENKSQGWRYVLDTTEDWVKQKQDWPINIRRKQEEQKSAAKNDKEKKERRAQQEHEWRRDSDTEKHNDAYAVKNASSDKEKRLEDMYSMHEIALLRGLEHENDYVSHLKENDGKGNAPKVPNQTQISIDEQDQFSPDNWLPRSSHLIRNTGKHPLNAEPDLSQLFSSGLITPNELHYVRNHGGVPRLLWEFHQLKVEYNSTTKIYSMEDIKGFDVINIPIALACDGNRRKELNMMKRSKGFDWGPGGVSCSYWKGPLLRDVLVDAGVPELPPDLGGKRYWVNFEGADELSEGNYATSIPFEYAMCAQNDILLAYEMNDVPLPPDHGYPIRVIIPGYVGGRCVKWLRKIWISQEENKSHYHIWDNRVLPAFISEMDGPFAEALFRHPDTACNEQNLNSIIAKPAHGETISLSQARKGSSYRIAGIAYDGGGHEVQRVEVSLDNGKTWLYCIRRFPEAPIRHGNKYWAWVHWHVDVDVVQLLRASSITARCFNVFKNTQPRDPNWNIMGMMNNCWYTVKLEIVNREQSAVPYMLFRHPTEPGKGEGGWMKPSTENRISDTRQEARAPQKQFTREEIEKHDKQHDCWIVVDGKVYDATSVLGWHPGGPAAILEHAGKVHQDTTDEFSSIHDDFAIQKLQECVLGVVTEKTANFIKKNAEAAAKETAYTPTRPLLPALSDTNPPRDPYRDGDGTFDLTVKTYFADENQPGGAMSSILDCIPLGEEVEIRGPTGEIVYNGDGNFIIDGKECHFSRVSLVLGGSGVTPGYALVARVIMTPQDKTTISLIDANKTEDDILMRDELDQFRRESRDKLRVTHILSHPSDSWNGLRGHVDEVKIKDNLFPPSDDSVAFLCGPPTMIQKAVLPVLKEWGYIEDENVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKC3</accession>
    <name>A0A7D5YKC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g008120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549696.2">
        <property type="nucleotide sequence ID" value="XM_014694210.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKC3"/>
    <dbReference type="GeneID" id="26239140"/>
    <dbReference type="KEGG" id="mbrn:26239140"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="72978" checksum="2473016C40EE1425" modified="2021-02-10" version="1">MLPKDISASELLSRLERLEALVASQAKTQAQTQTWPPGTGSPISADTRKAGYPESGPPTSLAAVPSRLQRLTADALWLERSCSGQKLLDSVVADPITFRTCPIRLITKPSGFIFEPEAATGAFGVTQAIRCIWLPRREEAHILLQKYLSDVSHFHHIIHAPSMGGLIDATYNGLEQGDRVDIGAILLLLSICTTTTYAWTTFDDSRCLFANYVEANSQATSWLKASLDVADHAHRTAHLSVECVQGMIIMFYVLCSLEGVSSRARSLVAKSIAMGRELALHRIDYSPNGSSGEVAGADAVKTEISRRVWWYLTATDWMLAQFSVPQEGTYTIHPNHMAVRKPRNVDDEELISGREVPDHAAEKPTCVSYFLQRIRLAEVCHGLLDRSPFILLSPETLDYRQVMEVDAKFKQFISEMPSFFSLGNTSLKDLPLDDPRCSPNITVQRYTLNLLLHRQLCKLHLPYLARGAVETPFAYSQEMCMKSARIIIQVEHQLRKENLVYVSFRQRMNMVLRSVFIATIALVLSACLGGDGDNGTASGEEVADAWRILEEARHQSPVASKLLELSVQVLKKHRGNHPALEAVNNHAAGKGRPPGGSPPMTPDSGHRDDGTNGMLPPQTTPESETAYLEQQWQALQGRMDLDAIDWDRLFWGLDAPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKP7</accession>
    <name>A0A7D5YKP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g008390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549668.1">
        <property type="nucleotide sequence ID" value="XM_014694182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKP7"/>
    <dbReference type="GeneID" id="26239112"/>
    <dbReference type="KEGG" id="mbrn:26239112"/>
    <dbReference type="OrthoDB" id="4941242at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="232" mass="24111" checksum="6DEE9B66690A0DEC" modified="2021-02-10" version="1">MSFYFQPPVFAVQPTTCVQPVVWAPATAVVPAYYTTVVQPVPAPAVVYATPPVIQVYTAPPMVSAAALPESQRPGLRVRIIFYGHGPGREAPRSLWCRAADATYPGVPTGSRLRDDIARLAELQNLAQGWRHARIVVAAPGSAAPVIAAELGPVLNDEVVRVLELQRDAGADEDAADAERKGVLQTSLAGGQGVFLTVCMDDEPGAGPSAPSSSSGGHVGDGDAAPLLNADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLC6</accession>
    <name>A0A7D5YLC6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ugtA1</name>
        <name evidence="2" type="ORF">G6M90_00g020950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548452.1">
        <property type="nucleotide sequence ID" value="XM_014692966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLC6"/>
    <dbReference type="GeneID" id="26237896"/>
    <dbReference type="KEGG" id="mbrn:26237896"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="457" mass="50425" checksum="DC8D554DEA93CEC6" modified="2021-02-10" version="1">MTASSLIFASNGGVDKTRLKILACASPFTGHTMPIINIVEVLIQRGYDVTFIAGDEFQERIERIGAKFFSVPTIHLVQPPEERNPSGQEFARMRHSLLKYFIEPTEAHKNVLYKVLEHMKREAPTHNIVILTETFYLGHVPMYLGAALPRGFTKRPRTVNIHAVPYTLPSRDTPPFCLGLIPDGREESRDTYRAQYEDMVTVTFADVMAAHEKTLRELGAVNYKAALPVDALATAADVTLQMCPPSLEYKRSDIHPKVRFAGALNHRPAKKSFVPPSFWEDVTRGDRIVVVVSQGTIAVDYADLLIPALQALKHRSDIFVVAILGHRGASLSAEVQIPPNARVIDYLPYDAVLPYASVFVMNAGYGGFIQSVLNGVPMVLAGGSEDKPEVAARGEYSGVAVNLRTATPSEAEIRGAVSAVLSNPKYKKRVLEVKKENEEMRAMDTVERAILEMAAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLU1</accession>
    <name>A0A7D5YLU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">APE3_0</name>
        <name evidence="12" type="ORF">G6M90_00g018060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985860.1">
        <property type="nucleotide sequence ID" value="XM_066129812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLU1"/>
    <dbReference type="GeneID" id="26238172"/>
    <dbReference type="KEGG" id="mbrn:26238172"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029034728" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="10">
        <location>
            <begin position="146"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="258"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="506" mass="55339" checksum="ECF33C6BF3CDF577" modified="2021-02-10" version="1">MTRIASLVALSAASAALQLPLQRPINDIAPHSAFHARPLVSSGTLQDSIDKDRLWERAEELYALARKSEDEFNHPTRVIGSAGHQATLEYIKSELASLGSYYNVSEQPFDAYAGRVREFRLVIHDKVPASTTAFSLTPPTKNNEPVFGQLILVRGTGCKASDYPHKVKGNIALMQRGTCPFGDKSQLAGRAGAIAAIIYNTVDEELHGTLGKPSPDHIATFGVSSKDAEDWVENMPRGEIFRGSAYIDATVQTIKTNNIIAQTTEGDADNCVMLGGHSDSVEEGPGINDDGSGSLSILEVASQLAAFRIQNCVRFAWWSAEEEGLLGSEHYVKSLSDKENAKIRLFMDYDMMASPNFAYQVYNATDAENPLGSERLRDLYTDWYTSSGLNYTMIEFDGRSDYDPFVRAGIPAGGIATGAEGVKTPLEAGFFGGEEGEWYDKNYHQIGDDLNNLNMTAWEVNTKLIAHSVATYAASFEGFPERTREVGVASFRKPKCNALSPQFCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNH6</accession>
    <name>A0A7D5YNH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tuftelin-interacting protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tfip11</name>
        <name evidence="10" type="ORF">G6M90_00g010140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549503.1">
        <property type="nucleotide sequence ID" value="XM_014694017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNH6"/>
    <dbReference type="GeneID" id="26238947"/>
    <dbReference type="KEGG" id="mbrn:26238947"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="244"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="398"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="804" mass="90412" checksum="C02C94A60D192083" modified="2021-02-10" version="1">MSGNGNFPFDPSRLTKAAAEEFSSSASEDEDDYRIPGMTADDDDFGDFNPRKKRRLGKNNKEKAALGIFGSDSEEDGPGSRWKRKSLRNKGMTFVSTASKQNKSDDEMESEDNRPVLGQLKNNGQGTDGEGQGEQGEEEEEEEEEEDTDDDNDGYDSTMAGVGLGFGEGLGSTFQRAAQSRVQSTDKSRISKVKPKFKGGSVLGMGFVPSSTNEPVLQETAAAKEPPQNKPQHSAFTSKGKINAKGFGARMMAKMGYVEGKGLGKEEQGRNIIIEANLRPQGIGLGAVKEKSEHERREEKRQAELRGETVIDSDEEEKKRRKAKKKAVGGLSGSGASTPRRQKTKYLTAEELKASAPGLQIPDAFTPILDMTGPGNKIITSTNGIMTPTSGVSESAELIEARKLVKRAQADLQAFSEEWRNLEERKAWVNVELKEREQEMEDLRSDFEKLQTFSNMVAEKLTADSNWDQVISCLQKAADIGALNADAADIAVAAIHPFFRDAEWDPLVEPSKFAPDLKKLSVLLIKPESEGQSVDKWRSNRMQQEGIYRRHQKATTPYESMMYKNWLPRVVAAVREWDPLTPSPMLDVVETWNDLLPPFVRAQVMDHVARKLETAVSDWNPKKKRQSHHLPHTWLFPWLQHLAPYHLDPKGTGLVADVKRKFRQLIDVWEFERGTVPGLKQWQDVLGSQWRPLIMSHVLPSMGRYLRANFRVDPADQELYLPILTGVMRWNRMLGDAIIAEVLVQDVFPMWYDKLQEWLALGEADLQEVAEWYSWWRGVLLKDMVNVKTVRAELDKGMQIMNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNT3</accession>
    <name>A0A7D5YNT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548729.1">
        <property type="nucleotide sequence ID" value="XM_014693243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNT3"/>
    <dbReference type="GeneID" id="26238173"/>
    <dbReference type="KEGG" id="mbrn:26238173"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="40925" checksum="2F99B1B711510A31" modified="2021-02-10" version="1">MASPLLAMGEKLSVTTAIIGLLAVGGKTIDALWDLNTPANKANSIFATALQEIKQCRSTVHVLYKTFSLVESAQLPFPERGTWIEADYLIATMTDTVLAVSDLQAICATLNLERQGLATPPAEDLAVGHDYSSSYEQSIQALCSRIRWHNLSMTMMMTILKCPGESDAQNSRVGLERRMTRLLAANTNLSGRMRQLEDVFDGQVVDRELLPHYSPPARQQAFWVPPRLASSAASMITTSAGGDQRSDNQDTLRVLSPFSGYTLADIPVLSIIPLPVTTAELVDGNEFYTFAYARRVSRDLSELMQYQAGQGTSQSLGVILGRTNNTSIDNGGSTSSTGSNESGPVVGEVQPDTQRKKWRFRRFRVKQRWRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPD0</accession>
    <name>A0A7D5YPD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g042940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986355.1">
        <property type="nucleotide sequence ID" value="XM_066130314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPD0"/>
    <dbReference type="GeneID" id="26240191"/>
    <dbReference type="KEGG" id="mbrn:26240191"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="567" mass="64698" checksum="11CD2AEE265BFBE9" modified="2021-02-10" version="1">MSLDQVPDEIIQHLLHHVSPEDTLQCFQLLCHRSHRLANEGLLWRYHCRSTFRYWHFDHGFGQKLHAAVASVDWKRLFLLRTRRNRTVSQLLDAILRTKVGRLRKIERICRLGYDAKDFLLVQCHAPESAPDVLARRYFSNAILDSIHRSIAIEEWHRLGLDRDSPPAHVAAQRLERALGAFDMFVLHDQPGDLDDISQMLDHLVIQFRASCANLAELTTRETALALNGWMRAKNLTGLQNPERNYRNLRNCLIGQALRHEEHESIPLISSALFCCLAGRLGLNAQCCAFPSHVHAIVFAQSGQTLDGHVVDSCHEQLERMYLDPYGLDSEVPASDLQNLLAHYGWQTSTDAFLAPVPPISMVLRTAQNIKATFARILELQEDAHPELSQLLRGNNAMNVDASLYSAMWASLMLTPPNTFEWYDRLASFLRRFAGSWPEDAWLVEKYLAPMYNSFTPLRDGFAHHVNRGLGDPWDHWRLVRDEDDVIPSVSRRDSDANQSVPFKIGQVFQHRRYGWIGVITGWSDQGTRPLPVAISRDTDVEGGAGDPSGQPRFPIRPPNQFYFICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPV7</accession>
    <name>A0A7D5YPV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNU13</name>
        <name evidence="12" type="ORF">G6M90_00g036480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547040.1">
        <property type="nucleotide sequence ID" value="XM_014691554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPV7"/>
    <dbReference type="GeneID" id="26239603"/>
    <dbReference type="KEGG" id="mbrn:26239603"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="126" mass="13344" checksum="01DCC87ED322B691" modified="2021-02-10" version="1">MAEDANAAWPLADAALTQEILDLLQSATHLRQAKKGANEVTKALNRGTCEVAILAADTEPLAILLHIPLLCEDKGTPYVYVPSKTLLGRACGVSRAVIAASINSNEASELAGQIKALRDKVERLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQ45</accession>
    <name>A0A7D5YQ45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tim22</name>
        <name evidence="11" type="ORF">G6M90_00g003000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542783.1">
        <property type="nucleotide sequence ID" value="XM_014687297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQ45"/>
    <dbReference type="GeneID" id="26244156"/>
    <dbReference type="KEGG" id="mbrn:26244156"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="174" mass="17652" checksum="07636A6A236DF35F" modified="2021-02-10" version="1">MNFPGGSSGAGAPTPGFGPQDPGVKAVQSAMESCYGKSVMSGVMGFGMGGLFGMFMASMSYDTPFGTPVTNSAGQNISSLPLRQQLKHGFKDMGTRSFSMAKNFGKVGALFSGIECGIEGLRAKNDLANGVAAGCLTGGILAKNAGPQAMAGGCVAFAAFSAAIDAWMRQPKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRC5</accession>
    <name>A0A7D5YRC5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxisomal biogenesis factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PEX3</name>
        <name evidence="3" type="ORF">G6M90_00g013400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549181.1">
        <property type="nucleotide sequence ID" value="XM_014693695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRC5"/>
    <dbReference type="GeneID" id="26238625"/>
    <dbReference type="KEGG" id="mbrn:26238625"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="531" mass="58509" checksum="67860B85CEC8B773" modified="2021-02-10" version="1">MFSSARRWLRNNRTPIAIGVGIVGAGYVATQYVLNKINDARERMSSDRIAKENLRRRFEQNQEDCTFTVLALLPTATSNVLAAMNTEQITYEIQQIKGSTKGLKSGGIESTSPPSIADTTMTEEDGKSMATSASIQSESGIHASQIASPTPFSAAAGQDGQQDGASAPRVSRKTKRQLWDDLTISAVTRAFTLVYTLALLTMLTRVQLNLLGRRSYLSSVVALATGSQQATISLENNDDDNPEQAYGSDFDTNRKYLTFSWWLLNRGWIQVMNRVESAVRTVFGSLSPRDLVSFDRFSDLTMEVRKLVEGSTADERRQTDWLAFLLPPRNEEEEVIRQSGILEDNSMQGGAAAEQSPAALRRLLDETADLIESPSFSHVLTLILDAAFEALVDKKLATEAFELPSQSPFPAPESLELRHSKLILLPKILSVLTRQAHVIGNGVPNEYLQEMETVRALEAFAAVVYSSNWENEIRDEGIMDSAVNISKGEVESQLIQTLEKSQQTGVGESIVMVDSPGGFEDAWEKAVQQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRK4</accession>
    <name>A0A7D5YRK4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trans-enoyl reductase ccsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ccsC_0</name>
        <name evidence="7" type="ORF">G6M90_00g063960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542488.1">
        <property type="nucleotide sequence ID" value="XM_014687002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRK4"/>
    <dbReference type="GeneID" id="26244437"/>
    <dbReference type="KEGG" id="mbrn:26244437"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="361" mass="38847" checksum="A437EACE1BCE6266" modified="2021-02-10" version="1">MTPRPTPRLNRAIIQSEHGGTLTQTFAREVPSPGPNQVLVRTAAVALNPSDWKMLSACPCPGAGCGSDYAGRVVRLGSCVTHLAQGDRVSGAVHANNPVDPSSGAYAEYSAVDASQLWKIPDAMPWTDAVAIGLCGIGTVGMAAWQNLELPGTPEEPSSKSEFVFVHGGSTAIGTMAIQLLKLLGFRVLASCSPHNFGLVEGFGAEKAFDYTSPTAAEDIRAYTANSLEYVMDIIADAKSLKLCYAAMGRVGGRYVQFEFVPDELAALRKTIKASWVLGIRLTGGEIVLDKGCGYPANAELRDWGRRLFRRVESWVREGKIRSHPSIVHEDGLDGIIDGVERLRRREVSGCKLVYVIDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRM1</accession>
    <name>A0A7D5YRM1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ASPG</name>
        <name evidence="10" type="ORF">G6M90_00g035640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546959.1">
        <property type="nucleotide sequence ID" value="XM_014691473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRM1"/>
    <dbReference type="GeneID" id="26239522"/>
    <dbReference type="KEGG" id="mbrn:26239522"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028914039" evidence="9">
        <location>
            <begin position="17"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="253"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="348" mass="36477" checksum="052D08DC08A754FF" modified="2021-02-10" version="1">MHNALLLLLFSPLAASTAPPVVIHTWGGPFTVAADAAHDALTNARSVLDAVQIGGAACESNQCDGTVGHGGSPSENCETTLDAMIMDGNTLNVGAVGALRRVKHAIAVARHVLEYTGHTMLVGDSATRFAAQNGFKEEDLATDRSRDMCEQWKRNQCQPNSWVGVVPDPKSSCGPYTPLENGASETAPGQDGGDIKGRGHDTISLVALGKDGSMAAGTTTNGKAYKIPGRVGDGPIAGSGSYVDSLVGGCGATGDGDLMMRFLPCYQAVENMRRGMSPAAAAEDAVRRMVKRFPDIQAGVVVLNNKGEHAAAASGWHFTYSFRGQGMNKTHVVQVDPINENRNMSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSJ2</accession>
    <name>A0A7D5YSJ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g037200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547081.2">
        <property type="nucleotide sequence ID" value="XM_014691595.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSJ2"/>
    <dbReference type="GeneID" id="26239644"/>
    <dbReference type="KEGG" id="mbrn:26239644"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="36477" checksum="11AD16853F66F765" modified="2021-02-10" version="1">MVLHNPNNWHWVTKDVTAWTKKWLEDNLNEISATNGDVEVKIVEVESIEGEAEVYQRKGKVKTVFDLELALRFAGSAPDADKVSGTIKFPEVQPDIEDYTFEVKLEDPAPKENQPVKELVRSQLVKELEKKFNLITSVLIEEHGKDIQHAAGSNPSSGFSTPKTHPQTSSPKPTEPSSAPSSTSGIVNTTTVTDKEEFRTTADEMYQTFVDPQRLAAFTRSPPKVFEGANKGGKFELFGGNVSGEYLELEPGKKIVQSWRLSQWPAGHFSKLHIEFEQNNVDHVTVMRVEWKGVPVGQEEVTKRNWLEYYVRSIKQTFGFGTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSX9</accession>
    <name>A0A7D5YSX9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g041280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547474.1">
        <property type="nucleotide sequence ID" value="XM_014691988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSX9"/>
    <dbReference type="GeneID" id="26240037"/>
    <dbReference type="KEGG" id="mbrn:26240037"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="245" mass="26001" checksum="0E07ADAB2F55B67B" modified="2021-02-10" version="1">MSTSTQTIAFIGATGGCGLAALKRAVAAGYTCVALCRTPAKLEAHFPDKPSNLILKQGNAHDAAAVGEALLRPSDPTAMVDAVNFSIGGSVSASLTMDDPDVCKKGVAALLEALGALRSRGVAGSPLLAVISTTGISAHGRDVPLLFVPLYHVGLKAPHADKRVAEQALFGSGERFVLVRPSLLLDGEKPDRKIRVHVESEKGVEHKEVGYFISREDVGRWMFENLLQDACPTEQYERKAVGLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT83</accession>
    <name>A0A7D5YT83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UFD1_1</name>
        <name evidence="6" type="ORF">G6M90_00g050170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545124.2">
        <property type="nucleotide sequence ID" value="XM_014689638.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT83"/>
    <dbReference type="GeneID" id="26242465"/>
    <dbReference type="KEGG" id="mbrn:26242465"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="378" mass="41741" checksum="336D1A419AEF382E" modified="2021-02-10" version="1">MFQPGFGGGFDPANPEHLYNMARGRRPVMQRFDEYYRCYPVVMAPGAERPELNYGSKIILPPSALDKVSKLHVQWPLLMEMINGEKGRHSHAGVLEFIAEEGRAYIPQWMMETLGMDVGDMIQIRTTSLELAKMVKLQPQSVNFLEISDPKAVLERAFRNFATLTKGDVFNFEYNDEIYEVAVLDVKPETDKMGVSMIETDVSVEFAPPVGYVEPERRSGTNTPGSTRSGVPTGGLVQSQGTMAQAIGYGSIAPSVTSNPTNFVGEGQRLTKKGSKTSTPKPATPVPAEPTAPKSRTGAPAPLRLAPNKLFFGYEYKPLKTKEEKEQEQEDSKRPHFAGQGQSLRGTVKRKGEADDKSKAPDKKGPSEGYRLDGRRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUA7</accession>
    <name>A0A7D5YUA7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g066430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986861.1">
        <property type="nucleotide sequence ID" value="XM_066130826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUA7"/>
    <dbReference type="GeneID" id="90967874"/>
    <dbReference type="KEGG" id="mbrn:90967874"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="258" mass="28385" checksum="219834CC2F87BBBB" modified="2021-02-10" version="1">MATSTKLYKPEQTICYGDGREQDLLKFIQDHPRYKQMQDSPLEVLSAVDEYGAQYNFLMNVGKDKGRIVAQQISKQQPRVMVELGCYVGYSAILFGSIHRQCGGTKYISLEINPDFAAVASAMIQLAGLHEHIEIVIGPCEVSLREARTSGRLKTIDLLFLDHQKSAYVGDLMLCEDLGLIDSGSVLVADNVISPGAPGYLEYVRASKDERNDLRVKAAQNSAPSVNPQTGLTYDSTLYRGFEPTGEPDGIEISLCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUD9</accession>
    <name>A0A7D5YUD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987423.1">
        <property type="nucleotide sequence ID" value="XM_066131186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUD9"/>
    <dbReference type="GeneID" id="90968054"/>
    <dbReference type="KEGG" id="mbrn:90968054"/>
    <dbReference type="OrthoDB" id="4961272at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="264" mass="29569" checksum="0452DFDAD64C48BF" modified="2021-02-10" version="1">MRSFKYHVAYWAVAYAANIMYRASTLTLGVPEVLFQALLVPLLVFFVTLVVQGPSPEPWPRLYYIASGALLVSLGSVSRYFYIPSVGVIQPNNFVHCCVAFEVAGTLESVRQDRQDIEPCSVGIFMEAVRRNLGSRRRGIVEFYSVWLSYMLTLMFVISILDLFLIRSYGAKATCLSIVGYYLPNNQGPAGSFALLFYVAAAVEDVAETLFLVILKRCGLRRPKVVEGATPLLDPRWGWDCFSCEIAQTSFMMVVMLLSTIFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW65</accession>
    <name>A0A7D5YW65_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g003830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542037.1">
        <property type="nucleotide sequence ID" value="XM_014686551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW65"/>
    <dbReference type="GeneID" id="26245068"/>
    <dbReference type="KEGG" id="mbrn:26245068"/>
    <dbReference type="OrthoDB" id="3202396at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30947" checksum="1DA15EF1FA28EE7F" modified="2021-02-10" version="1">MGEFKPKLPPVGPPPVEKPIPLTILLLRSLLAQRQKIFLTAAAQLLICTLFPGRYAAVPIATLALAITTTQLADLFLPRPAPPPSYMAAVVPGRTTALLPGPSGAFGSSPSSRPLVAFNIGAQFNHPRGPLCPHGKEIAHMFADMKHALLQRRDELGLISVADWVGSRPGAADTLMASYFFRDVESVHRFAHGEMHRRAWDWYNAVRPDHIGIFHETFVVPAHSYETIYANCTPVMLGAGVVRCAEMEGERNWRNTLVSADSAELKSQWQRMNRDGSGIPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWA3</accession>
    <name>A0A7D5YWA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g001940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542886.2">
        <property type="nucleotide sequence ID" value="XM_014687400.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWA3"/>
    <dbReference type="GeneID" id="26244259"/>
    <dbReference type="KEGG" id="mbrn:26244259"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8185" checksum="AD23371A76C94029" modified="2021-02-10" version="1">MNSVNQHASPPQPAASAPAVTRENLQRLPETPNLQYYLGHAQNHEKIALGVQTAPANYGQMLQTLERAFPTGGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX07</accession>
    <name>A0A7D5YX07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl-15</name>
        <name evidence="6" type="ORF">G6M90_00g035080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546902.1">
        <property type="nucleotide sequence ID" value="XM_014691416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX07"/>
    <dbReference type="GeneID" id="26239465"/>
    <dbReference type="KEGG" id="mbrn:26239465"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="203" mass="24170" checksum="7AD746A2CBDA95F9" modified="2021-02-10" version="1">MGALKYVEELQKKKQSDVMRFLLRVRCWEYRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNQGVNQLKYQRSLKATAEERVGRRCANLRVLNSYWINQDSTYKYYEIILVDPQHKAIRIDPRINWIVNPVHKHREARGLTATGKKSRGLNKGHRYNKTQAGRRKTWLRHNTTSLWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYU2</accession>
    <name>A0A7D5YYU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tpi-1</name>
        <name evidence="12" type="ORF">G6M90_00g015950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548933.1">
        <property type="nucleotide sequence ID" value="XM_014693447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYU2"/>
    <dbReference type="GeneID" id="26238377"/>
    <dbReference type="KEGG" id="mbrn:26238377"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="247" mass="27027" checksum="83D1103909572B06" modified="2021-02-10" version="1">MARKFFVGGNFKMNGTVSSIKEIVKNLNEATLDAEVEVVVSPPALYLQLVRDSIRSGIEVAAQNVFDKPCGAFTGEISVSQLKDSKINWVILGHSERRTILKESDEVVASKTKYATENGVGVIWCCGESLEEREAGKTIEVVSKQLEALKAQINDWSKIVIAYEPIWAIGTGKVATTEQAQAVHKAIRDWLKNVSDKVAEETRILYGGSVNEKNCAELGKQPDIDGFLVGGASLKPAFIDIINCKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYU9</accession>
    <name>A0A7D5YYU9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DOA4-independent degradation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DID4</name>
        <name evidence="10" type="ORF">G6M90_00g041760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547519.1">
        <property type="nucleotide sequence ID" value="XM_014692033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYU9"/>
    <dbReference type="GeneID" id="26240082"/>
    <dbReference type="KEGG" id="mbrn:26240082"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="505" mass="56748" checksum="24B309CB45027916" modified="2021-02-10" version="1">MDYVLLPKIELHAHLTGSVSRPTLHEIWKRKKASGQTDLEDPRVVMPEGKHDYNLQTFFPLFSSYIYNLLTDEESIRYAINSVLQDFLADGVVYLELRTTPRSTTTMSAEAYITVLLGAIEEFESLHPQLHTRLILSIDRRHSIRTAESILDLAIRLQDTNKCGVVGIDLCGDPTARPGGEVAVFTPVFEQASRAGLGITVHFAEAEASGSHDELRTLLSWNPGRLGHVIWEDEEARKVIVERELCLELCLSCNVQAEMVHGGFEGHHFGHWKGVKGPKISLAILEWAFGKRMTPAERLRKNQRMLDKAIRELDQTRVKLEKQEKTLIQQIKTSAKNGQMGACKIQAKDLVRTRRYIEKFFSMRSQLQKISLRLQTYRTNEQMMQAMKGATMALGSMNKSMNLPQLQRIAMEFERENDIMEQRQEMMDDAVDDAMDVGVEEEGDEVVEQVLEEIGIDFNQSLGETPTAIGNPAIAEGKIAQAVGGGSGGDPVDDDLQARLDSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYX3</accession>
    <name>A0A7D5YYX3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g111840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987810.1">
        <property type="nucleotide sequence ID" value="XM_066131837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYX3"/>
    <dbReference type="GeneID" id="90968262"/>
    <dbReference type="KEGG" id="mbrn:90968262"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="148" mass="15944" checksum="CA2A012D0CD5195B" modified="2021-02-10" version="1">MTTNHGEKPSTPQRDIAVSAPRNANLVSAEREVQVSFPDGGFQAWLVVGWIFNLCLFLVFFVGVQAGPVFDRQGVRLLLAAGSLCVVASLMLLSISTTCYQIMLTYSVLGGLCALANIFIRTRLAPRVNGPDGGANGKRNSVWMGQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ49</accession>
    <name>A0A7D5YZ49_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter prlL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prlL_2</name>
        <name evidence="8" type="ORF">G6M90_00g030360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539456.1">
        <property type="nucleotide sequence ID" value="XM_014683970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ49"/>
    <dbReference type="GeneID" id="26247730"/>
    <dbReference type="KEGG" id="mbrn:26247730"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55934" checksum="40B742DCC98CF58E" modified="2021-02-10" version="1">MTAPKDTELERVELGSLAGKVSLDIAPGASEAERDLFRTFASRDPEWVAAQDKRLVRKIDTRMMPCLIVMYLLNFLDRSNLAQARQGTLEKDLHMRGTDFNLATSIFFVGYLLMQLPSNIIITRVRPSIYLASAIVLWGVVSTCNAAAGSFVHLIVIRFFLGFAEAPFFPGAIFLMSSWYTRAELTRRVAWLYTGNSLANMFGGLISFGVLRDLNGVHGIAGWRWLFIVEGVATIGVGIMSAFILPDYPQTTRWLSDEERAFASWRLLADINEMDDGKSTTVWQGLKLALKDYRLYLFILLAHMSLLSQTFQYFFPSIVQTLGYDPLITLLLTVPAWFATFLVSITVNWTAAKTEDKSIHIFCLMVVAAAGNAIATGTTAPGARFFAMFLMPMGSIAAYTIIVGWVANSFPRPLVKRSAAIAIVNMIGNTASIYGSYMYNKDQGPQYIPGGSSNAAISFLVGVLALILRYLHKWENRKLERAENEAAANGTLTGRGPEGFRYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z062</accession>
    <name>A0A7D5Z062_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pabp-1</name>
        <name evidence="18" type="ORF">G6M90_00g038840</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547240.1">
        <property type="nucleotide sequence ID" value="XM_014691754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z062"/>
    <dbReference type="GeneID" id="26239803"/>
    <dbReference type="KEGG" id="mbrn:26239803"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="242"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="345"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="646"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="373"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="584"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI67343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="743" mass="80367" checksum="6DB56A3DC3CF4254" modified="2021-02-10" version="1">MAANTTSGAVDQLATDLNNTSLNNGSGDAKPTVDTTVGAAGSEDASAPTPSSAAPHPQNSASLYVGELDPSVTEAMLFELFSQIGAVASIRVCRDAVTRRSLGYAYVNYNSTADGEKALEELNYTLIKGRPCRIMWSQRDPALRKTGQGNVFIKNLDVAIDNKALHDTFAAFGNILSCKVAQDENGNSKGYGFVHYETDEAAHQAIKHVNGMLLNEKKVYVGHHIPKKDRQSKFEEMKANFTNIYIKNVSTEASDDEFRELFEKYGDITSSSLARDQEGKSRGFGFVNFTTHESAAKAVEELHGKDFRGQDLYVGRAQKKHEREEELRKSYEAARLEKANKYQGVNLYIKNLDDDVDDEKLRQMFAEFGPITSAKVMRDAPSDGSDDDKEKEEDNEKEPEAKEEAKETEEEDADKKADKKGDKKLGKSKGFGFVCFSNPDDATKAVAEMNQRMINGKPLYVALAQRKDVRKSQLEASIQARNQLRMQQAAAAAGMPQQYMQPPVFYGQQPGFIPQGGRGMPFPQPGIGMGGVQGGRPGQFPGYPQQGGRGGVPQQMPPNMYGMPGQFPPQYGQPGTPQFMAAMQAQQAAMGGRGAPQGGRGVPPPNAGPGGMPGYPPNNRQGAGRGNGRNNAANGPNQAGRGEGNNSSVLQSQLAGAQPAQQKQILGEIIFPKIQAINSELAGKITGMLLEMENSELVNLIEDDGALKAKVDEALAVYDEYVKSQGNEGAEAGEAKKEEETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0A8</accession>
    <name>A0A7D5Z0A8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ptc2</name>
        <name evidence="14" type="ORF">G6M90_00g076900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545413.1">
        <property type="nucleotide sequence ID" value="XM_014689927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0A8"/>
    <dbReference type="GeneID" id="26241446"/>
    <dbReference type="KEGG" id="mbrn:26241446"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI70384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50186" checksum="83CEABAE1882B93D" modified="2021-02-10" version="1">MGQTLSEPVVEKTSDKGEDDRLVYGVSAMQGWRISMEDSHTTVLDLAAGTDLDPKIHSPKLSFFGVFDGHGGSTVALFAGENIHNIILKQDTFKAGDYAQGLKDGFLATDRAILNDPKYEDEVSGCTACVSLIADNKLYVANAGDSRGVLGIKGRAKPMSQDHKPQLENEKNRITAAGGFVDFGRVNGNLALSRAIGDFEFKKSAELPPEQQIVTAFPDVEEHELTDEDEFLVLACDGIWDCQSSQAVVEFVRRGIAAKQDLDKICENMMDNCLASNSETGGVGCDNMTMSIIGFLNGKTKEQWYEEIAKRVANGDGPCAPPEYAEFRGPGVHHNYEDSDSGYEMDAENKGKSFGVGGYRGRIIFLGDGTEVLTDSDDTELFDNADEDKDLESQVSKNNSTSKEKEHAPTSTADAAAAESKQEPETQSKSGKEIVKASAAVSEQQDEKKEAKPKSTSDESKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z142</accession>
    <name>A0A7D5Z142_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g055240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986818.1">
        <property type="nucleotide sequence ID" value="XM_066130597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z142"/>
    <dbReference type="GeneID" id="26246189"/>
    <dbReference type="KEGG" id="mbrn:26246189"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30404" checksum="5DF5A25C95FE5316" modified="2021-02-10" version="1">MGGGMSAVLALVKGLFEHGLIQVPTTKSGRFHRTQLINLSRHGIRNPISPDSWNENMNIAAYNPEDYSSLPSLSAAFQQLQHKGGESIITGPIRDIFLSHGAQDAYGIALLHKHFDIRPTDRLVDIQNVSSPWETGGDIEPVLKKYHGVIMPRSLRFSNGMLKPYEFDFVEEERSMNMDENFLEKLLQFLQHSELDQVLGLRVLDSRDPGASIEVTERNSNIMIPLGAIDEANVIPAMWDFGPEEDQRCHCSEYCYTDNKGKHSGQGNHGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1N3</accession>
    <name>A0A7D5Z1N3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SSU72</name>
        <name evidence="11" type="ORF">G6M90_00g058530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544429.1">
        <property type="nucleotide sequence ID" value="XM_014688943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1N3"/>
    <dbReference type="GeneID" id="26242841"/>
    <dbReference type="KEGG" id="mbrn:26242841"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="255" mass="28034" checksum="644B2FD4902F722D" modified="2021-02-10" version="1">MEVANGAADAVIPNGSGDHTGGYKLKFCTVCASNQNRSMEAHLRLSQAEYPVISFGTGSLVRLPGPTITQPNVYQFNKTSYDSMYKELESKDGRLYKANGILNMLDRNRGVKWGPERWQDWAVGIPRLQHSTDKGSDGTEGGVVDVVFTCEERCWDAVIDDLLSRGSPLNRPVHVINVDIKDNHEEAHIGGQGILDLANSLNAAAREEREAIGAAAFDSGSASSRASFDERVPEILGAWQERWPNLPSTWTLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1W0</accession>
    <name>A0A7D5Z1W0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC multidrug transporter B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">abcB_3</name>
        <name evidence="13" type="ORF">G6M90_00g047700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986170.1">
        <property type="nucleotide sequence ID" value="XM_066130432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1W0"/>
    <dbReference type="GeneID" id="26242228"/>
    <dbReference type="KEGG" id="mbrn:26242228"/>
    <dbReference type="OrthoDB" id="4952489at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="885"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="82"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="388"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="668"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="981"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="956"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1245" mass="137530" checksum="C3691A088C025F1E" modified="2021-02-10" version="1">MVLLVLESQNKTESLLSMYKGVSPEDSAGILSRTFWWWLMDLLAVGKQRILRVSDTPRLSSSLQPSLTRKAVLQAWNDRGSQPVIISRAISFITNDQGGVAQSCRAYEIFFAALIVYFGLAISSSMYKNTLNKLDILIRESLVHLVYDKTLNLSHHGSDAGRVVTLMSTDIDSVSEMGRLLHASWGQAVELVIGMILLAREVGWVFPVPLVIIVFASRVSRFVAQNVRSRTKSWNDATQARISTLSTVLNSMRSVKAMGLSEAIAKYINELRDKEIDRSKHVRWMQVLYNASANANGLFTPVITVVLYAMLAASRGERLDTKTAFTTVAILSLVTHPANMMMTIFPKFVGIMANVDRIQSFLLEPSRVDCRKIIDGSQFTETENCTGIRLDDVTVKFKSTTAATLKHINLNLPKHSITACAGPTGCGKTTLAKTILGEVSPVQGIVTVSSRRIAYCDQRVWIPIGTIRDIICTFATKVDESLYQEALRVCCLDYDLQRLPDGDRTVVGSQGVNLSGGQRQRIALARMVYSGASIAVLDDPFSALDGVTENKVVDNLLGKNGWFRRAKVTAFIITYAAQHFQHSDGIILLQDGHISAQGDWRAIKSRASEMLKFNFEETQSSTVEPTGKSQYSTAKQAETDADKDLHRSVGDMTLYSYYIRSVGVWNFLLLATCTALYATFNTFTTYWFKLWTESDGDRVVFYIVGYVLLAFTAWAATSANLWSTFILLAPRSGRLLHQSLLTTTMAAPLLYFSSTDVGIVLNRFSKDISLVDRQLPLALSNLCSQIFKMLAQAVILMQVQRLLLVTLPICIVIVYLVQRIYLRTSRQLRVLELESYSSLNSWFLETTEGLVSIRAFNWIKPATGKNLENLETSIRPSYSLVSLQCWLNLVLDLLVSCIAIGIILIAALWRSETSAANVGVSLNLILVANTTLVRLVESFTQLEVSLGAIARLNEVETQTPSEDRPWEDQVPPSSWPEKGSLTLSGFSAGYNDDHNVLRDINLSVGRGEKLVICGRTGSGKSTILLGILRLIESSGEVEIDRRLLSQVPRNIIRKRAFITVPQEPLFLPSASLSFNLDPDAQASEQMLQEALQSVGIWDVVCEIARGKDSDPLSQPASSLQALSAGQLQLISMARAIVKMKIISQGVEYKDGGVNVDSPKPILVLDEATASLDAETEGRIYDIIESEFVADGHTVVIVAHRISVLAKTMRPGKDKVAWLQDGRVVKVGDYEEIVKFASSTAIGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4M7</accession>
    <name>A0A7D5Z4M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-coumarate--CoA ligase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g085920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541151.1">
        <property type="nucleotide sequence ID" value="XM_014685665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4M7"/>
    <dbReference type="GeneID" id="26246140"/>
    <dbReference type="KEGG" id="mbrn:26246140"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="5">
        <location>
            <begin position="444"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="61423" checksum="4833C14DE794F137" modified="2021-02-10" version="1">MPIQSEWTADIPDIDVWSMYFEQPKEYPDNHVLFTDGDTDRSYSFNDIKNGSIAFGKGLRHMFNWKKGDVLALFTPNCIDTPIVTYGLLWAGGVSSPANPTYTVDELARQLLDSKAAALVTQKPFLKTAVQAAQKAKIPLDKVILMGDGRDETGKYKHWTEITAKGAWFQPKRTVLDPKKDLAYLVYSSGTTGLPKGVMLTHSNVVSNAYQTSRLDAKVLNWDSDRHLGVLPFFHIYGLSVIMNVTMQTGSQMIVLPKFDLEKACKLIEKHSITFLYVAPPIVLALGKHPIVDKYDMTSIRWINSGAAPLGVDLVEAVWKRLSIGVKQGYGLSETSPVTHSQLTDEWWKFQGSVGRLVPLVEAKIVDENGKELPRGEAGEILVRGPNVFHGYWNRPDLNKETFTEDGWYRTGDVGYACKRGHFYITDRMKELIKYKGFQVPPAELEAKLHGREDINDVCVVGVWDNEQHTEVPRAYVVVRPGVEESDELKQDIINWLGERVGPPKRLRGGVRFVKEIPKSQAGKILRRVLKDQIKKEEGQGTRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4S4</accession>
    <name>A0A7D5Z4S4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chorismate synthase</fullName>
            <ecNumber evidence="3">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARO2</name>
        <name evidence="8" type="ORF">G6M90_00g032080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543143.2">
        <property type="nucleotide sequence ID" value="XM_014687657.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4S4"/>
    <dbReference type="GeneID" id="26243944"/>
    <dbReference type="KEGG" id="mbrn:26243944"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="118" mass="12759" checksum="FF9B3BDBA8BB0EAC" modified="2021-02-10" version="1">MSAFSSSNSPHHPTRQTSTASIAQHVHLRTLLPVTTAGESHGKSVSCIVDNCPPGLALVEDDIQPQLNRRRPGQSAITTPHQRPKDYGNKTIDLYPRPSHADWTYIEKHGVKASSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z602</accession>
    <name>A0A7D5Z602_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">met-7_0</name>
        <name evidence="14" type="ORF">G6M90_00g042480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547585.1">
        <property type="nucleotide sequence ID" value="XM_014692099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z602"/>
    <dbReference type="GeneID" id="26240148"/>
    <dbReference type="KEGG" id="mbrn:26240148"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="595" mass="66626" checksum="74779085CB0042E8" modified="2021-02-10" version="1">MSPLALGESIPQDTAHAVSVSLPTWKSNIGYEEGEKWVVEKMATGYPRFFIHKSIQALASDIVSDYGLSDQQAMLFPTPAAAQRCINFVTNAEPSYLQKINLVELALDMSKTLSPLLKKLAPTVSAILLPKAAFPIAKQYWQHTGDGVSSRRAEFCHSLLRDGLLIPTNSTQISSEASPWAIRGPKRYQRTGNNGNSKDTGSYNYEESLESSRFLEERFGRNLDLAFVERAKSAIRRRIAGCLVQDMDSLPVMASNSRGLQNLHEDDVYLFPAGMNAIYNAHRALLYARGQMKSVNFGFPYVDTLKILQKFGPGCEFFGHASSADLDKFEELLRTGHRFLALFCEFPGNPLLICPDLQRIRRLADEFDFAIVVDETIGTFANINVLPAADIVVSSLTKIFSGDSNVMGGSAILNPNSRFYGQIKKAMNYIYEDTYWPEDAIFMERNSRDFFNRVDRINTNAEAICATLQQHASVKDIFYPKCNPSRHYYDEYRLPNRGYGGLLSIVFHSRQHAEAFYDSVEIAKGPSLGTNFTLGSPYVLLAHYQELPWAAQFGVAEDLVRISVGLEDTEMLQNIFNRALNATETMPKTDSDFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6C5</accession>
    <name>A0A7D5Z6C5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g050750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="97" mass="10727" checksum="743E72E873BCFAC0" modified="2021-02-10" version="1">MKLSITLASIIVLVAAAPVEVRDPQPVRDRIDLDRGGFATGEYYNGVDLPPSNQGEFFSGTQRPSYDRGDFADEESTDEELYPNDFTLGRRKTAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z783</accession>
    <name>A0A7D5Z783_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">G6M90_00g051280</name>
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    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26247369"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
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        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sds3"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
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            <end position="264"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="478"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="211"/>
        </location>
    </feature>
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        <location>
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            <end position="333"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="543" mass="60347" checksum="5A5CDF1A006E4719" modified="2021-02-10" version="1">MAASDNTVPSALGGKPERRSPPPASQSKRDRKRQALMERLSSMTDKFQREQDMTYRDQLQKIQYEIGLVQRFDPYDTNALEVAAELQREHRQTQGPPVHAESARSLMDMAGIKFPNFIDEIEDLIEIRDFQLTQSKNEYERKVQEYKNTHAYKVETARREHMALTSTLRDRLINTLTQKKNRLNREKEVLEINDSNALLLNPNHFSLTNPGSPGGTHGKRATRLRKDADDLQMFSDKKRKRNPGEDDGSPGPMRRGLDPNSTTPLWQSEKARAVAKQNGPIYSIDKLFTDKELSLHYNSAALAAHQYVLRNRVNGNASSPDDSDSGNGDDNDADSVLSAPMMERQVSHATRSTRGGANTNFLDDKILGVEGIANFEVPANLDLMHAQEPPKMPPHVPQQYLKPYPRSADQNFPVPLSQDDIMSDLSVMGFLKQYDHSHKPGAHLDAPTGLRKILEAVSIPYQQGRFVAITSAAREDPENFRDSLGIPTSGLRDQLSPGHGGSNQSVAGYSASAIPMSRQSSLGGVAMSRQGTTGSGRGRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7C6</accession>
    <name>A0A7D5Z7C6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g105460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541533.1">
        <property type="nucleotide sequence ID" value="XM_014686047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7C6"/>
    <dbReference type="GeneID" id="26245783"/>
    <dbReference type="KEGG" id="mbrn:26245783"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028921182" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="70"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="532" mass="57888" checksum="8C1089011CDB5494" modified="2021-02-10" version="1">MRVLWLATALYTLTEAAALTPETKAVCSGLHAKFPGQLVWDPIGPQATDTISHASTYNTALFDYWNAASSNNRAGCAFFPSNADQVSVAVKLLNAYPTVRFALKGGGHNPNLGHSSVDQGVLIAFRPNSQYAIPSADGETVEVGAGCKWEDVYSALEPLGKTAVGGRLGDVGVAGFLLGGGLSYLSAQYGFACDNVVSFECVLANGTIATASSTSHPELFFALRGGGNQYAIVAKFVLKTYGIGQNGTIWGGVRTYTADKRKEVLSAVANFTANNADSKAAIIPTFNFFSTLGVNVPGSLVFFFYDGLEPRRGVFDEFDAIASFSDSTKRRSYTDLTKEVLAGDMKGLRFQIRENTFPNMPAGDMNSFLNSHYNLLVKKSTEAALGDVLDFKLFSFAVQPMPRGIARASLENGGPNALGLVPEHGDRVWMEYDIAWLNPLCDDKCPGFFEKLVQSQHDLHREKYSGIYPTNYESGDLEWLSYNPIFMNDAMQGQDVLQSYGNETYSRLLSIHKAYDPRGFFSDRQGGFKFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7G1</accession>
    <name>A0A7D5Z7G1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-dependent RNA helicase DHX8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g100930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546255.1">
        <property type="nucleotide sequence ID" value="XM_014690769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7G1"/>
    <dbReference type="GeneID" id="26240678"/>
    <dbReference type="KEGG" id="mbrn:26240678"/>
    <dbReference type="OrthoDB" id="413653at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24286" checksum="28071CEEF161F374" modified="2021-02-10" version="1">MASTPPYRQIRATYTPDTITVYQAYKRSIADAAVKHQKLNASPDFRPGRMTWVKPSWSWMMYRAGYSYKDPGQERILALRMKHAHFIALLDKGVLSAHTERIGGAGGGEQGPRDKTSEVRIQWDPERDERLRVLPYRSIQIGIPGSLSKQWAEEWIAEIEDVTEKARGLKAALDERADVTREELLDMGYVPEERVFEVGHDIRERLGMDLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7K7</accession>
    <name>A0A7D5Z7K7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g068440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540596.1">
        <property type="nucleotide sequence ID" value="XM_014685110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7K7"/>
    <dbReference type="GeneID" id="26246703"/>
    <dbReference type="KEGG" id="mbrn:26246703"/>
    <dbReference type="OrthoDB" id="4941385at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="38993" checksum="7678452722FAFB00" modified="2021-02-10" version="1">MSFISTFDSDRTLSQLYHDAKRLPEYASTTLFGHWLRVYIFTEKDWVISTERPTREHHDRTRLDIVVQTLLLDPTYATIKSKFLRNTWIFWLTAEGKKQKSGREDLRYAEEQAYTKTWNYLHENKDAVRSCWVMTYFGTQARLWACQYKGSGALEAFLPLEGENGEKSSYLDIKENEHYFNIGWAYIKENLVPEPNEFEEFWRLTTSPAGPSAEAAPDPSPTDDRPSVIYPAYYTFVVVVKLIKTAETAEGLRTQVRHSDKREQHFPRQLWRSVKVMCDNNVHADGFVADDLGYWTWTLEPELEDEDPEHIGTDKTKGKGKGKAKEKHHHKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7M4</accession>
    <name>A0A7D5Z7M4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g100400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546310.1">
        <property type="nucleotide sequence ID" value="XM_014690824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7M4"/>
    <dbReference type="GeneID" id="26240733"/>
    <dbReference type="KEGG" id="mbrn:26240733"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42076" checksum="8A99C58B30784F43" modified="2021-02-10" version="1">MVPINRLRSPWHSRCQRQHHYHQHHATASKSSSPRPSLDKTLPPPPNVAASPSTSRSTSEPTLSSITTVLIGAKQQPFSVNCQLLCEASPFFSERLLENSQPKSVCLWLPGESSTMFALFVHWVHAPGSFRQFLDHSIASAHNTGEQAAQDIHWAIIRLHLFASHLDLYKLQDLAMDAIQDMYLKYDWDVPPSLITYLYTQCESLPAVRVRRWAVAMVAFSQTVGSSIANLKFHPQDSATSDPARFRALFDSLPDFAADYATHVRNMKAARLDIRSKNPQLRISANKLRNDERLFGFRECSFHSHRAAIGERRCPHSRGRSRSKHPDMGLRLRDSYTGVRELIPEPLFTSGRREEARLKHARPISSEVREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7P9</accession>
    <name>A0A7D5Z7P9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenol acid carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g052240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540355.1">
        <property type="nucleotide sequence ID" value="XM_014684869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7P9"/>
    <dbReference type="GeneID" id="26246717"/>
    <dbReference type="KEGG" id="mbrn:26246717"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20944" checksum="145DD1119E49EF20" modified="2021-02-10" version="1">MSSLTPLPHFLSATKFHPSFETDVRDVHLVYDYDTHAIDGKPEKWRYEMWFFSENRIVYAIHGGPMAGRINYQTATYQCIRPGELWQCNWLEETGTICSLVYDITNKSITTFIAFSKGHWEMPHYAHGDKRDAVDFDRWRGLAKLGIHTDRYLLSEQAQILQHFKGKGDLVPIDDDVPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA19</accession>
    <name>A0A7D5ZA19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-dependent flavin oxidoreductase nadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nadA_1</name>
        <name evidence="6" type="ORF">G6M90_00g093050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541948.1">
        <property type="nucleotide sequence ID" value="XM_014686462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA19"/>
    <dbReference type="GeneID" id="26245416"/>
    <dbReference type="KEGG" id="mbrn:26245416"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="44263" checksum="AE8E8036E75E9A8F" modified="2021-02-10" version="1">MDLEIARPLTLPCGLTIPNRLAKAALAEGWGDKNRLPHKSLVETYGAWADGEWGLVMTGNVQVDTAYLGTPDDNAVNSDIPREQLLQSWKQWASTCSKNGTPTIVQLNHPGRQSTPGAGSHGYFGKTIAPSVVPVRLGDGLIARFLSALVFGSPREMDTADIQHVVGRFVDGAKLSHEAGFAGIEIHAAHGYLLAQFLSAKTNTRTDAYGGSPKKRARIVVEIIEAVRKAVPKEFCVGIKLNSVDHQSQTELEECVEQLEVIVAAGIDFLEISGGTYENPEMMIGKANPPVSERTAAREAFFIEFAHAIRDRFKGVPLMVTGGFRSRQGMEAAIKDGGCDLVGIGRPAILNPFLPKNTIFNKEVKDEAARLYVKSVAPSWLSSVLGMRSIGGAAETVSALLPMTLLRSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA25</accession>
    <name>A0A7D5ZA25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD-dependent protein deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NPD</name>
        <name evidence="6" type="ORF">G6M90_00g086580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542456.1">
        <property type="nucleotide sequence ID" value="XM_014686970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA25"/>
    <dbReference type="GeneID" id="26244970"/>
    <dbReference type="KEGG" id="mbrn:26244970"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="398" mass="43317" checksum="7B574E0151C0DCBA" modified="2021-02-10" version="1">MPKPRMRIPYTDILASPTILPASATTIQGGLAALANFFQAPPPNSLPDSTVVLTGAGLSVASGLADYRGVKGTYRVNKTYRPIYYYEFVGSHEARKRYWARSFLGWSTLHKATPNAGHYAIRDLGNLGLIRSVITQNVDSFHPKAHPQIPSLELHGYLRSTVCTSCKTEFSRDELQGQLARLNPKWAALLEEAIASGALDTESTEERKFKGLKANPDGDVDLPEAPYTTFRYPPCPKCLADPPEDANGQKQLVRVDSDGAWVAPSTAGILKPAVVMFGESIARHVKAASEDAIDGAGRLLVLGTSLATYSAWRLAKRAKDRGMPIAIVNMGGVRGEDRFFTDLDPRQGGEQGVRVELLTDQLLPGLVSRLRQTGAGSHHHPATEIRLENSTVFKDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAX2</accession>
    <name>A0A7D5ZAX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g105420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541529.1">
        <property type="nucleotide sequence ID" value="XM_014686043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAX2"/>
    <dbReference type="GeneID" id="26245779"/>
    <dbReference type="KEGG" id="mbrn:26245779"/>
    <dbReference type="OrthoDB" id="4540712at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="152" mass="17145" checksum="20AD902B6FD1D10C" modified="2021-02-10" version="1">MATQENIQRLIQIRNARLQAASEARDVDALMKWQAADATFTDMVHGTVVSGWDAVRDHYAQMYRAMPTFRILRSETTGYTPEFVVGEFECEAVAGADMPQLGVNKGDVLGIKAVSLFWWRWQGKGEWTGALDDEAVGGWKIYRERVYSVPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB95</accession>
    <name>A0A7D5ZB95_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g082660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543492.1">
        <property type="nucleotide sequence ID" value="XM_014688006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZB95"/>
    <dbReference type="GeneID" id="26243669"/>
    <dbReference type="KEGG" id="mbrn:26243669"/>
    <dbReference type="OrthoDB" id="4795535at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="29896" checksum="9AE31065C5A68D5C" modified="2021-02-10" version="1">MYGTRLPYRITEKDRKDFFLCGPALTEEMRQQLFELVRADEHNFNIPPFTLVQAIDPDTEDSLLHVAVRAGSMNGVVSLMARFDLVMRTCGGGPQNPFYIWERHAFIAHQNRNGDTVLHVAARMGNLKLVIMLYRFLYNHWSATCPDVEDPEDLDGEEAPENVEFPETAGEAESAPYLMLLITRNLAGRDAASEACCVGNYEIAEWLDAVANRLDPEGNRRSKKGISDMVRMVKKGFGYALMAGRKKRETRQNLSNSFRKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBN9</accession>
    <name>A0A7D5ZBN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g093260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987404.1">
        <property type="nucleotide sequence ID" value="XM_066131435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBN9"/>
    <dbReference type="GeneID" id="90968126"/>
    <dbReference type="KEGG" id="mbrn:90968126"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="89" mass="10404" checksum="0E6B19942C08CBA2" modified="2021-02-10" version="1">MDEMQKLVKRTISSVGAKDDNKIVITLPRAIDGHALVDRFVGHLEAYLGIKAAYNPLYYDGYHEFDDFRNEYEKKFGKPVYVGPYMRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBS9</accession>
    <name>A0A7D5ZBS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g103420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987779.1">
        <property type="nucleotide sequence ID" value="XM_066131614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBS9"/>
    <dbReference type="GeneID" id="26240429"/>
    <dbReference type="KEGG" id="mbrn:26240429"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="319"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="694" mass="77785" checksum="EB20713A36663915" modified="2021-02-10" version="1">MEATPIGESIKTSDVAVARLAERHPEYDPKADESVQIKCDRKRPCSRCIKAGTECVLQGTGEKQRPVSKSYVQALEGQISALEQVIRKLAIADSTERDEILLELSLSSAPEDGAPLDKKPQPNPTGDHGVAVARLRAGQLRRPRDGNATQFFGGTSSFQIHFSRDETQTTPRTSANSDGTMVQADCQVNSMLEMTDLALEESSSSGSGCFQYAPHDQTSQTLMAAFFTEQYQYNMVVYREYFLRDYDVGSGRYYSDLLLYSMCSLSALLYDDFFKLSDVFSGQAQALLFATLDKPDLTTLQALILLGHREIAVGQTSKGWLFCGMAFRLAHEMGLHLDPSNWDASTSSFRDREILRRVYWGIFIADKQLSLYFGRPPALYPSESDVRNTIRLQYPHDWQNLLETYICRGATVPEYENGVALVGSFIYQAELCKIIHVMIADLFENRRGDVDPAIAAAKSRKIHVSLTKWLASLPGTLHWNQWTVGQVPSPVLHLHMLFHTVMIILHRPPSNMFEKPGISESEDVEICYESLQAILRLMRSYSRYYRYRSLPLDFAQTLSTATGAVMMKRFFQKSSWEDPEIERSLSLLTEAMDEIQNSLPCVKEIRDCVSVARQCRETTLPPDVPLNAPDLMNGLELGGADATTGPLTSFDDELGTLITDEFLSAQLQVQDGSGFDFEPFDFNNPPEGTIDSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBT6</accession>
    <name>A0A7D5ZBT6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein pet117</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pet117</name>
        <name evidence="6" type="ORF">G6M90_00g110900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543770.1">
        <property type="nucleotide sequence ID" value="XM_014688284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBT6"/>
    <dbReference type="GeneID" id="26243157"/>
    <dbReference type="KEGG" id="mbrn:26243157"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9998" checksum="59BF231F7390D56C" modified="2021-02-10" version="1">MSRASKLTLAGTSLFAACTIGFVHFQQKWEKEAMHEGVVRDMEQQRVKRERQLDFDMQRALEAEYKQHQTVRDSTAEMDAKDAPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7G1QC24</accession>
    <name>A0A7G1QC24_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal Protein S3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Rps-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rps3</name>
        <name evidence="2" type="ORF">G6M90_mt0002</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="1"/>
    <reference evidence="1" key="1">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Kouvelis N V."/>
                <person name="Kortsinoglou A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="LR792747">
        <property type="protein sequence ID" value="CAB3396433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP058939">
        <property type="protein sequence ID" value="QLI74834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7G1QC24"/>
    <dbReference type="OrthoDB" id="4360278at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAB3396433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="446" mass="52604" checksum="014E08541412AA9D" modified="2021-02-10" version="1">MKIFTNNLNNNSKTVALKNKVGDIGKIKYLPSFSKEWKNVVYSYNKNNLKNIPMNDVNINKIIQSYFNLYFKDHKYIGSKKFILLKRRRNFLRRIYVSNAEIKHTNNKAIITLFTVNREKNLLKKKYLKINKKISKNLIKRYFLLYKSNINKIYDILSNAQANNNKYVFISDNISKKRFLKYKLEYLNQFITLKNLYLKKIWSVIINRYWKTYLRLLRKYDLMYSLNQYKFNNQILLPKLSNILNKIIGKKIEYNIINLKSIAYNTDLFTQALALKLKKTRMNHIKSMFSILNRAYLPKINTIKERTLVKGQNNVDLFLDKYKDLKIISNLNTNNNLDGLLSTIHSPKGLETSKKEIHNTIYNSIGYKNMSGIRLEVKGRLTKRYRADRSIYSLKWKGGLKNVDSSFKRLSSVLFRGNSNSNVSYSLTKSKRRIGAFAVKGWIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPP7</accession>
    <name>A0A7D5UPP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g008970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="34794" checksum="240CEA63FC68F301" modified="2021-02-10" version="1">MDLFAAGFNAWNQLCFVPESGDVAEPKDLSTFTKVLDDDCLERPRAGLYYTLVRGRAGYYRAGIGIETASDEDIQRSYRACRAGNGLTLIFDGPTSAENTGMRLGPNKHFLTVHPCYDDFVSKSNPTSWPCNSQVREVASFAAGFIILYQNGQVATMGDPRYQDCLAREVTSDEPADQPGFVPDLINLGEPIKHVTAGGYCLTALTQSGSIYIWGRRCTGQRQSGHSAFAELCGIPNYLGVDGDKDVQDVALGDSHAIALTTDGTVYVIGRNDNGQLGLRQGVDMAAKTWTKVKLGVPDGCQVVGVAAGPKSSFILTAQKTGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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            <end position="188"/>
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            <end position="327"/>
        </location>
    </feature>
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            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="457" mass="48883" checksum="5B74285B394D2980" modified="2021-02-10" version="1">MAIHRGGSVYQCLANGSVYQCLANLTAALELVGQLNAAEYNGAAGALSLLPTAGALLGAPTREMWIVYKLVPLAGVLSMFLSLGGSITPSNVGEYDPAEPFSYGGFMPTTGVTATRHMLSSSANSFNGSVRQLCSTEAQDDVSAAQRFAAEVQQRADDDSGGDVGPGLFVAMALQSILVIGLLVPMWYAQRGAVVTWWCRVWGWMYFWYLLVSAVSIFDNLVAAPFTRSWTIRVSRKPTGILLDDTVPKITDRRGGRYANALEALKAGPNTNQHIRIATDKGSGYSRTCFYVVISIQGISRLHAIAQVLSKGASVAVFAFGTALFASATLMSISVALMVLCILLVCGVAGRVIAMWIVAQISRENKPILHKLVKSETEAGEFIHAICELDLQLEIHGHVIMSGWCIKSRSAFLSAATYIGLMAKPFNAIQLAEKAMRGAVVSQDVAGTRATEWGIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ03</accession>
    <name>A0A7D5UQ03_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g011320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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    </dbReference>
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    <dbReference type="GeneID" id="26238834"/>
    <dbReference type="KEGG" id="mbrn:26238834"/>
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    </dbReference>
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        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="142"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21549" checksum="1F7733A54916E045" modified="2021-02-10" version="1">MTRVYVYSSALVAFVAATGMIVASIFIPNWVSYSVTTPKGDVVEKHIGLHKTCSNLNSPTCREFPTAELCQAGERYFCDMWKTVGFMASLAAIMCLASLVSFLVVMKGGKYKRETGWPLVASMLTLVSVVEFAVISIVAYLFDHDEQFTIPGWNLDVSWYISTVSATIALLAAAGLAVSAYLLSPEGGYEFLEDPIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQH1</accession>
    <name>A0A7D5UQH1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Meiotically up-regulated 89 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mug89</name>
        <name evidence="9" type="ORF">G6M90_00g011740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
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        <property type="protein sequence ID" value="QLI64273.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129716.1"/>
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    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI64273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="427" mass="47544" checksum="60D9EE698E5CB232" modified="2021-02-10" version="1">MSDNPRGVEHTDSIDSHDSAPKQPEKTKSRRPPNTAFRQQRLKAWQPILTPKTVLPLFFTIGIIFAPIGGLLLYASSLVREIKLDYTHCINDAPDFTTFADMPGSAVESAFKNANSSVRAQWARKKDVNVTLHNGREIKGNQCVLQFTIPEDMGAPVLFYYQLTNFYQNHRRYAESCDLQQLKGDARSYSDITGSKCTPLYGIKPNDTGKPYYPCGLIANSMFNDSFSSPAWQNPPNDGKARTYNMTDKGIAWDSDKDLYGPTKYKASDIVPPPNWAIAYPDGYTTDGMYRPPDLQNWEAFQVWMRTAGLPTFSKLAMRNDQDTMVSGIYQITVDDHFPTIEYKGTKSILLTTRTVMGGRNNFLGIAYITVGGVCIILGAIFTATHLLKPRKLGDHTHLTWNKVPASKSSGPSTAMASGREIRPGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQW6</accession>
    <name>A0A7D5UQW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g008760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
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    </dbReference>
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        <location>
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            <end position="141"/>
        </location>
    </feature>
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        <location>
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            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="345"/>
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="673"/>
        </location>
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        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
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            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="673" mass="72878" checksum="265EA34B4DD1C802" modified="2021-02-10" version="1">MSEADEVAEDYRHALEDLSSNMRFEISNLTVIARENTEHALAIAEVLQQHILKAPPTKKLPALYVLDSIVKNVGTPYTLYFGRNLFKTFMESYAVVDNNVRRKMEEMLKTWKDPVPGSMDTRPVFSHELVRPIENALMKARAATMPQPGAIPGRPRSAMIPHRNTPTPPGMRGQPGGPAGPYPAQQYGYPNGSRPGEAPYPGQQQQFLPSSSTPQPHGSIPASFQPLLSGPYGSAGAGTLAGISVETLSNDIQNLIVAMRAEFAQNPNDNSVQNRLKALLDLQGVVRNTSLPPDQLELIKNKVTELAAVTMKATPSQNSTPVPGYVPPQGHPPSHPAPVTPVPASVPEQKPQVTLDSLLGPGAMAALMARQAAASQNATPAAPFPNAPIRSPPPTHAETPKPPPQNPMSLLERLRQAGMIPSATPPSSGVPVVATPPPPPPPQSILPLNISSILASAKAAASQQGLDGLNGPVLDSTSLKQQFRPSTVAALYDNLGPPCSQCGRRFKTDEEGKRKKMAHMDWHFRVHQRTTEAEKRGTHRSWYVDYQDWLRSRETVDSDHIPAPDDGAGQASEANKGPKYIPVPDPASGINNVCPICQERFENKWLDTAQEWVWLDAVLVGNRAYHASCHAEATRDREGTPGPSRRTPEPVLGKRKAENAISSPKIRTLKTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URI9</accession>
    <name>A0A7D5URI9_9HYPO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="11" type="ORF">G6M90_00g022660</name>
    </gene>
    <organism evidence="11 12">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZnF_GATA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GATA_ZN_FINGER_1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI64851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="432" mass="46410" checksum="86173ADC029376AE" modified="2021-02-10" version="1">MEEPSTLSQTNEPISRPSPTSTLVSANLQQLPAISALAVSNAAQSPPQLRATAAPQNPTYTGATPPAATNGNGNGNLPTCQNCTTSTTPLWRRDEFGSVLCNACGLFLKLHGRPRPISLKTDVIKSRNRVKTIRPDLAAKKKAQQQQAANFGLGADVSGAALSAQNAAAAAQAIRRTSQKPNGNEGSDSPISRTGTPSMYNQGLPSFMVDDPYQGGSFNGTSENGDRDMPQTHEQLIAHNSSLKTRVSELEVINELFRGRLSQLEQQEAAARHGQEIAGVEQTQLRTQLDASQETVTQLQTQLEDSHRRENNLKRRLDELELELKAVQDALDGDVERPNKKPRIGNEVPAAVPTPMAEEEQPVPQAEPQAEPQAEQPEEQPEESVVKEETMTEPAAAEEPAAEETINEAAEETNETIDEASIEDAVPAASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URS0</accession>
    <name>A0A7D5URS0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS efflux transporter aclA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aclA</name>
        <name evidence="8" type="ORF">G6M90_00g017810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548751.1">
        <property type="nucleotide sequence ID" value="XM_014693265.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26238195"/>
    <dbReference type="KEGG" id="mbrn:26238195"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="301" mass="32550" checksum="1C3FBBA5A74E8140" modified="2021-02-10" version="1">MNSHGVSHHPIIGGALAEVNWRWVFWLNLPVSGASALVIFFLLQVKTRRRQTWRAALARVDFLGNAIFMPSMTSLFFGLIMGGTPGYEWGSWRVVMPIVLGIVGWAVFHVHQASRFCAEPTMPPRIFKKSTGVMAFIIIFLASIIVQAVSTFLPIYFQAVKDATPLESGICFLAFAVALVVFGSVAAGTLDSGRGKWIGYQIIAACGAGFIFTASLPSALASLAEKDVATATSAFAFVRALGLVWGVTMSAIVFNGQVNHNLHYVDDANMRQLLTDGRAYAFTSGSENGDLSIAKLPEPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URV1</accession>
    <name>A0A7D5URV1_9HYPO</name>
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        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g019150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URV1"/>
    <dbReference type="GeneID" id="26238069"/>
    <dbReference type="KEGG" id="mbrn:26238069"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF13">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="192"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="693" mass="77312" checksum="60C4AB3A38965338" modified="2021-02-10" version="1">MAARRGMLADIPDFSIFRGAAKCTTHHRPGTKQLELVGGLMVSTLKLSKSAQKGCPWCAIFWEAFKRSVGTSKPADQDFIYWRHDGESFFEPWCTSAQSSPGKGEFKIQIYTDDLAGATSVHSHFPFKNYLNGQTDTEQTMSQIDYWRQQCSANHVQCSPVASWVNLPTRLIDVSSLADIKLVETSGRQGQYVCLTHRWGDQGMPTRTTTSSLDQLRQGIPLESLPPTFRDAALVTRRMGSRYLWIDSLCIIQDDNDDWERESALMAPIYKNGLLTIAAAWASGPRDGLFQTVPSVVVDSRNLELARYKLPFPVMVRRRLRYSVGHLRRDEEHGILDRLWVLQERLLSPRVVYFGFNEVAWECMAGSACECEPMLANYAVAEYSPREPFNPKAAYSLSTSAEHSASIVGQSPELWHHIVNAYTGLDFTARRDKFPALSGLASEVARMRPGDEYLAGLWRSTLMMDLLWRKRKGGDWQVTAFGKHYDLNNVFGGSDVGQAAFNNKIARQEMKNREIRQQDAEKLAPSWSWASINTQVEYEKELNSANMGLVDAEGAELLDADCAHRYGMGMLLHPTTASVTIRGKLATVEAKSVKALPGEIVLYRDDHAMAFSAADNPAEVGLGGRLYCLLIAAGRVKTRLAMGRIYGLVLAEAGDGLGGKLFQRVGMFQETFTYGKEWCMFDGITGTVDVVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URW9</accession>
    <name>A0A7D5URW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g025110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548070.1">
        <property type="nucleotide sequence ID" value="XM_014692584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URW9"/>
    <dbReference type="GeneID" id="26237514"/>
    <dbReference type="KEGG" id="mbrn:26237514"/>
    <dbReference type="OrthoDB" id="5346581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="79" mass="8870" checksum="6BCECB7F0E2042F4" modified="2021-02-10" version="1">MAQLADGLPTIDVYREGYSRRNLGGNPLLPHESLCEGATERTRAFRAEFDPSVLQFKTSLVQAFQNADLGSRQFDLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USD0</accession>
    <name>A0A7D5USD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GDI1</name>
        <name evidence="7" type="ORF">G6M90_00g018860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548654.1">
        <property type="nucleotide sequence ID" value="XM_014693168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USD0"/>
    <dbReference type="GeneID" id="26238098"/>
    <dbReference type="KEGG" id="mbrn:26238098"/>
    <dbReference type="OrthoDB" id="1683373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="198" mass="22301" checksum="47EDEE3FEE246335" modified="2021-02-10" version="1">MASHEEDSMPEETQGYKLSQPKQSLAQYEQMDAGDESLQRYKKSLGLGGGKDVSDPNDPRVCIIRALTLDSPGRDPVTIDLSTPGSEKSLKDKPFKIKEGSKFTMSAEFKVQHEILSGLHYVQVVKRKGIKVSKDSEMIGSYAPNTENQPAYTKKFQEEEAPSGMLARGHYNTFSSFVDDDKKKHLEFEWSFDIAKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USF1</accession>
    <name>A0A7D5USF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ampC</name>
        <name evidence="3" type="ORF">G6M90_00g027140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547873.1">
        <property type="nucleotide sequence ID" value="XM_014692387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USF1"/>
    <dbReference type="GeneID" id="26237317"/>
    <dbReference type="KEGG" id="mbrn:26237317"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="2">
        <location>
            <begin position="426"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="550" mass="60931" checksum="97110C2545216550" modified="2021-02-10" version="1">MEHDSGMKLRHNLEAQEALISKICRIAGAPGLSISVLHRGTEVYSHHVGHASVKDGKLPDGDTIYFIGSMTKAMVSALVGILVQDGTLDWKAPVSHILPELAHAFDGRGSEITLVDLMSHRIGMAQADALWLQCAGNILLSKSEALDAWISQPTVRAFRADFLYSNFAFETVGRIIEESTGKILGANLQEKIFGPLGMTRTSLNDEFSKDPNAAKAYFPLKDGTPVEVPVPTISDKTIMAASGGVRSCTNDLARFYKNLMHAANDQFNHQRTSTPGSPFKQLSTIWSPHNQLPVHSMRETSYALAWARTQLPSPLGSFNYNKHLVPAMPVIGRGLPSRLVVYHGGSMQGFTSAVYLLPETETAVFALQNSSALCDACDWVPQMLVQTILSGLPQCDIDFVQLATVSAARGVKLADEVEEELQRSRERGTNPRPLKEYVGRFWHESKSFRIDVTVESDETLSMCFQGMPSETYCLRHLHHDVFVWNEPHDVPARRGRFQTRPVESYRIRFGSTSQDGAIDRLYWLYDETHAEPGMFRTEGGLLAADVDMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USW7</accession>
    <name>A0A7D5USW7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS siderochrome iron transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MFS2_1</name>
        <name evidence="9" type="ORF">G6M90_00g009860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549530.1">
        <property type="nucleotide sequence ID" value="XM_014694044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USW7"/>
    <dbReference type="GeneID" id="26238974"/>
    <dbReference type="KEGG" id="mbrn:26238974"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="70"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="588" mass="63944" checksum="E805A5BC7F8E2ED7" modified="2021-02-10" version="1">MSETQHPRPMPAHADEYMEKGRDGVVHDVSNAFDKPEHGAGATSDREAQAGVLEVEAIATVWSKTSLIVAYVLIWIVYFIMLTQQAAEAALNPFVTSAFQQHSLTPTVGILSSIFGGACNLTVAKVLDVFGRPQGYMASLVVVTVGLVMMAATTSVEMYAAAQVFWTVGTAALLYSVNIFVADTTALRNRALMTALTASPNIVTTWLGGPISQGFLEGPGWRWCFGALAIIVPVLCLPLFVLLMMNYFKAKRQGVIKPRAGSRAPWQSLLYYCREFDAVGLLLITAGLALFLLPFNLYTQQALGWRSPLIICLLVFGVVLLALFAVWERFFAPVTFIPYALLLDRNMVGACVLGSVLFISFWCWNSFFSSYLQVVQDLSVTEASYVVQIYGLGSSLFSIAAGVAIRYTGRFKAMTLYVAIPVYTLFMGLMIYFRDPSMSVGYLIMCQIFISFAAGIIIMTPQIAAMSAADHQHIAVVMAILSMFSSIGGAIGLTVAGAIWQAVFPVKLAEYLPPEDLPNLVSIYAALDVQLSYPIGTPTRTAIQHAYSDAQSMMLTAGTAIWAVGFAAVAIWRNTDVKNLKQVKGQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT78</accession>
    <name>A0A7D5UT78_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein lifeguard 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LFG4</name>
        <name evidence="7" type="ORF">G6M90_00g002220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542859.1">
        <property type="nucleotide sequence ID" value="XM_014687373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT78"/>
    <dbReference type="GeneID" id="26244232"/>
    <dbReference type="KEGG" id="mbrn:26244232"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="275" mass="30629" checksum="708D39592AAC511D" modified="2021-02-10" version="1">MATNTKYQPAPQQDPDDYTQAPPAYAEGSSSRDESQGLFGPPRSSEDNLPDDFKFGGSVAEATVDIRNQFVRKVYTILTVQLAVTAAVSGLTFFSDAYRTWIQSHPGVVWVSLIGALVFMGLTYWKRKSYPTNLLFLSLFTLAEAYSISVIVSFYKTSIVLNAVILTAGIFAFLTLFACQTKYDFTSWMPYLFGALWALVLFGFMAMFFPYNSTAELIYGGVAALIFSGYILVDTQLVMRHHHVEEEIAAAISLYLDIINLFLAILRILNSQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTE4</accession>
    <name>A0A7D5UTE4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elsinochromes biosynthesis cluster protein HP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HP1</name>
        <name evidence="2" type="ORF">G6M90_00g001960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986087.1">
        <property type="nucleotide sequence ID" value="XM_066129522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTE4"/>
    <dbReference type="GeneID" id="26244257"/>
    <dbReference type="KEGG" id="mbrn:26244257"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
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        </location>
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        <location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">4556</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9584" checksum="B45E814D8CBDBE2E" modified="2021-02-10" version="1">MSNADRDEMTEKAGAEAMVKILGGECRLRPNTGPWNLERAYEDDWVKVLEVEDDNTPAAGILELSLGARFEHTRRRTGEQGSRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Oxidoreductase</fullName>
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        <name evidence="5" type="ORF">G6M90_00g048390</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <submittedName>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="72"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <begin position="248"/>
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        </location>
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        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI66995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="490" mass="52608" checksum="FB10E67A19199EB5" modified="2021-02-10" version="1">MTFSSGFHMPGGFHTDGIHQGLFRPPVSPASSSGYLTQGRPCGEGPTPKRKRIRDDARQFDHAQQQEGIHDDITTNASTVLITPAGRHAAHNGRAYTLAGQLDTPASGPGESGILGDSTYSESDYRKALGSKRSRHDNDFTDPTGHTPLFNLPTQPYQSSGWGTLAFSTIGGVVGKVWEFCKAGAFKGFYAGGGRGFEMQPGDGIIPDGSILDPAWLQNDEDDEQHHRIPGHFPQAYAFCDQEATEDTLISSGASTPSAPAAKRRQTAPTDELGRNWVMIKDHASGTDSTPRRTSAAYRQSPRNRNQGPSLATGRRISTPQNRRVSSKVASPAPPRGTPRNGFNLSPPATLEPARPASSASYASTRSPSPTKVTNIAPSIAASPTPHSSRGHGRRRSAIPAPSHAPFTHSRTHSSASTASSRGAVDDLDNSPRLDAEAKHLAARRHREERDTDVRIAAFNKQLQDMIRQGKEALGTTIEVDGEDGGWEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU50</accession>
    <name>A0A7D5UU50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU50"/>
    <dbReference type="GeneID" id="26242437"/>
    <dbReference type="KEGG" id="mbrn:26242437"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="441" mass="47700" checksum="8C9A43C8DFABEDAA" modified="2021-02-10" version="1">MTSQQPPSASRRPRLSLQIKTTVCSPPSKGLRGIPLNPSDPTTFNTMSNIYVTAIERSSAIQSEPVTAIKTLQNFSLQSPIERNGLKSRVATSFVPTYPETPLTAQPVSPQQMDFVYPSTMTATPPLSAGPVDNSSKVFTFPPSADSSRTNRPPEPPADDRIPRRRRTPHSLPGITSQLPYTHPRSLHSILRNSPLPPRTAIPPPSPRRQSLRLQEKAAKKVEYDSPLEEEITTSKYVRSHIDLLSEDASPISPVYMHASSPGITAGEITRLPDVALAFTANEIQDGGQTPGPVEEMGRRMAGLAASPVRRKREKKRRWVWTIGQDDEDDSMGGAVAASRAESAHKKARGEDDVPQLTYEELPTPSIESISSVAGSDADVSDTCSVVSADHTARRCLSVPSDTEVEAKTPIAPTGGQKKRDTPIPELADNGDGSTRSVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5UU62_9HYPO</name>
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        </submittedName>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="45" mass="5275" checksum="AB1FE9171137AB54" modified="2021-02-10" version="1">MERKSYVTITITITITIVTSPTDVLKEKSKIQLRRQNGRQREMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUB0</accession>
    <name>A0A7D5UUB0_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">Acyl-CoA ligase azaF</fullName>
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        <name evidence="3" type="primary">azaF_0</name>
        <name evidence="3" type="ORF">G6M90_00g041100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="22"/>
            <end position="377"/>
        </location>
    </feature>
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            <end position="507"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI66938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="533" mass="57953" checksum="22C00FDF31690E60" modified="2021-02-10" version="1">MDYITRMLSNPLQNVHCLIMVDADRPGRTLSWQEYSVTVKRVAVGLREAGVADRDGVGLLSPNDIYFHVFGDGAIAAGAVFVPIPGFVKEADLANCITSGDVKWLFASPELIELALATAETLAMDTSRILVFDPPGLDPYNGPKLSFSRLMEADETVWRNPYNGQDPRTLTAIRLFTSGTTGKNKAAEISHATQVARLDSDHAVLPLGSKVLQITGIYHLSGQTVCNRACAGMLTAYVSRVDNDPATILDKIQVYGIDAVLFPTVLIKKLTAALLDGVRPRDTLQSLRYVTFGGSFCGTPVLEALKDLLPREAHLRPVYGSTESWFASIAQDWTPGYVGSPMEDVQVKVIDPETLEPLVPGIEGEICLRSAYVFDGYCKNPEASKSAFLPGESWFRTGDKGSLDVRNGQIALTGRYKEIFKVNSVQVSPSEVAEQLMLHPGIEDAVVCSTPARNDDDAVECMAYVVRRKDLTAQEVVDYIATKLNRHKSPTGAVVFCEHITRGAAGKPVRDHLVAQTPLPGSARYLSLSASHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUF4</accession>
    <name>A0A7D5UUF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g044170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692265.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26240314"/>
    <dbReference type="KEGG" id="mbrn:26240314"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
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            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="40778" checksum="245EA8AE7877F7B5" modified="2021-02-10" version="1">MLRPYWMVCLAALTAASLKDLANCDPLRKDMRNDPIAQKSCPKKTRTEPSKLTVASDCPPDAAFAGKASFDFTTANWDNVLDFWAVDEATANDKKRLDFDTDGNGVAMGMWKPGDAPTLVSSKYLLFGKVSVTLRAAKGNGLITAVVLKSDSGDEIDWELLGAYDNQAQTNYFYDGQALFNTYNDTYDLAASSFDALQKYSLEWTDQFLSFSVNDTIRKVWYVGEIPAAKWPQTPMQVKLGVWSVRNDSDRGEIAWAGGVPDWGSAPYRGYFQSIEVEDYTGFCNQTDGYVEYQYDERTAGWQKIRIAGCQSRPGPELPAPSPVHTGDATATETGETGGPETTAADDDNGGAGLSAGPSSALAAVLCLVWFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUI1</accession>
    <name>A0A7D5UUI1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase C 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plcC</name>
        <name evidence="3" type="ORF">G6M90_00g051640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684362.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247403"/>
    <dbReference type="KEGG" id="mbrn:26247403"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028962832" evidence="2">
        <location>
            <begin position="25"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="623" mass="69801" checksum="111D8C9032F735FC" modified="2021-02-10" version="1">MARSGNFWPQAMAIVAGLLGVAKSDSLKDVEHVVLFMQENRAFDHYFGTMAGVRGFNDANLQTNNGVPVWKQKTSPKLTNSTDYVMPWYLNYLGGNWSEATQCMIAGSNGWYQNHAAWNGGTNDHWALNNTPYSIGYYKRDDLPTQWALAENWVVGDMYQESVIASTSPNRVMWISGSINVPGGNLSPDLGGNPYIDNYETPGCDDNGINCYPLKWKTAPEYWEEAGVSWQIYQDGTDDYDNFDDNPLAWFQQFQQAKQGSNLNTKGMQGRKLQEFYDRAANGTLPEVSIIIGYRELAEHPPYSPHDGAWLENKIAETVIKSPKYNRTTLIISFDETGGWFDHVDPYRSPNGTRGEWYNDKAGIGYTFAGPGFRVPFYIISPWTRKGGVFVEHADHTSQLQFIETWQAAKSRAFKSREIVPWRRENMADLLNAFDWDNPDYSIPELPKAPEPHRNSRGKFDGASHCMGLYGDPRPPVPYSGSGATTDMAGLVEHGFKPIRGNLTEGRYLVLEMGRYALANAEKVVTGKACGRHDSKSQRWVVHVEELGGTRFKVSSGESGKYVCAGLALCSDKCKAIVFDVRFKPGRGYSFAVRDGEYLVADDRGELSLNGSSAYWTIYSVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUW6</accession>
    <name>A0A7D5UUW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vacuolar protease A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pep2</name>
        <name evidence="14" type="ORF">G6M90_00g047510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544869.1">
        <property type="nucleotide sequence ID" value="XM_014689383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUW6"/>
    <dbReference type="GeneID" id="26242210"/>
    <dbReference type="KEGG" id="mbrn:26242210"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="85"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI67430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="42544" checksum="A95F116B2DC89FCB" modified="2021-02-10" version="1">MKSALIAAAALVGTAHAGVHKMKLQKISLEEQLAGASIEQHVRALGQKYLGARPASRSDVMFNTKAPQVAEGHPVPVSNFMNAQYFSEITVGTPPQTFKVVLDTGSSNLWVPSQSCNSIACYLHSTYDSSSSSTYKKNGSSFEIRYGSGSLSGFVSQDVVTIGNLKIKDQDFAEATSEPGLAFAFGKFDGILGLGYDTLSVNKIVPPFYQMINQKLLDEPVFAFYLGSGEEGSEAVFGGIDKDHYTGKLEYIPLRRKAYWEVDINSIAFGDDTAELDNTGAILDTGTSLNVLPSTLAELLNKEIGAKKGWNGQYTVECAKIASLPDIVFNLAGSNYSLPASDYILELQGTCISTFQGMDIPEPAGPLIILGDAFLRRYYSVYDLGKNAVGLARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVS7</accession>
    <name>A0A7D5UVS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair protein rhp54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rhp54</name>
        <name evidence="15" type="ORF">G6M90_00g042320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547570.1">
        <property type="nucleotide sequence ID" value="XM_014692084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVS7"/>
    <dbReference type="GeneID" id="26240133"/>
    <dbReference type="KEGG" id="mbrn:26240133"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="235"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="568"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="807" mass="90808" checksum="2FAC9C00445FEEA7" modified="2021-02-10" version="1">MAPTASTPSGQKDQSIPTTRYHSTSSALGKLYQPFKCPGAACPRTSSSDRSSRKRRRVDYSGTDGDSSEDKSYTNNDRLALATRDVNKYPVYRAKEKHLVFRKAFSVPLKDKSTASYNPNRPPPTLGLRQGAVVSPRPLHDPSGEFAIVLYDPTVDGKPDNSQESEKLNTTANDIQKPQLDAPLVHKSLAEILGIRKKVTKEQPQVPVVLDPKLAKILRPHQVEGVKFMYRCVTGMIEEKANGCIMADEMGLGKTLQCITLMWTLLKQSPEAGKPTIQKAIVVCPASLVKNWANELTKWLGANAITPFAIDGKASKEELTRQLRQWAIASGRSVTRPVIIVSYETLRLNVEQLKHTKIGLLFCDEGHRLKNSDSNTFNALNSLDVSRRVILTGTPIQNDLTEYFSLTSFANPDLLGSRLEFRKRFEIPILRGRDADASESDRQRGDVCTAELLGIVNKFLIRRTNDILSKYLPVKYEHVVFCSVSPFQESLYNYFITSPDIQALLRGKGSQPLKAINILKKLCNHPDLLNLSDDLPGSECCFPPEYIPKEARGRDRDVRPEYSGKMMVLDRMLARIRQDTNDKIVLISNYTSTLDLFERLCRSREYGCLRLDGTMNVNKRQKLVDRFNDPNGEEVVFLLSSKAGGCGINLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQSLSSCVVDSAEDVERHFSLDSLRELFQYRPNTTSDTHDTFKCKRCKPNGKQHVKAPATLYGDTSTWNHFVNTCLQSIQDLLLRQEHGLGQVSAVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW07</accession>
    <name>A0A7D5UW07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g042570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547593.1">
        <property type="nucleotide sequence ID" value="XM_014692107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW07"/>
    <dbReference type="GeneID" id="26240156"/>
    <dbReference type="KEGG" id="mbrn:26240156"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35244" checksum="47A399F411571AF9" modified="2021-02-10" version="1">MVLSAKAPTAHDGSAAIFSPSMARIAASTAKDWSYVDSWLASKFPDSYTLPRFERNPSTLKALLAVASISERADDSRHLLAGAEKIAQGEGSHIDGYFEDLADDPPRSRMTSGIREQILSAISAHLDQDGKAALDAMGDAAVQHGISLPKLEDLSNQLIALQTTLFETSQASLRADFWRSFLYREAKRTTDWLATAQSQNYNLPPELAKQNLDLQRKTKAFIAHLSDTQERIATCIPSGKGSDPTIQLVTEEEEQFLAVLSHKKDLDAQLMVFQGLPSDTNKARDEVDTLRQKLRGFTSRRDQAFESLVEQASPVKRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWD1</accession>
    <name>A0A7D5UWD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase tropI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tropI_1</name>
        <name evidence="2" type="ORF">G6M90_00g035790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546974.1">
        <property type="nucleotide sequence ID" value="XM_014691488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWD1"/>
    <dbReference type="GeneID" id="26239537"/>
    <dbReference type="KEGG" id="mbrn:26239537"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="255" mass="27942" checksum="71D1D08D84CB644C" modified="2021-02-10" version="1">MASNPPARCCSLGSLFEGKPTGKLTKIDNKIDAYVATPPEGKARNGYGILYLPDVIGIWQNSQLMADLFAEQGYVTVVLDLFNGDPVKLNDKPAGFDIMTWLKEGTDGNNPHTVPYVDPIVEAGIKYIKGLGVTKLGAVGYCFGAKYLVRHYKNGIDVGFVAHPSFVEEDELAAIGGPLSIAAAETDSIFPSDKRHKSEVILKATKKPYQINLFSGVEHGFAVRADLKVKVQRFAREQAFLQAVAWFENYLLEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWD6</accession>
    <name>A0A7D5UWD6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hsps-1</name>
        <name evidence="7" type="ORF">G6M90_00g050580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545163.1">
        <property type="nucleotide sequence ID" value="XM_014689677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWD6"/>
    <dbReference type="GeneID" id="26242504"/>
    <dbReference type="KEGG" id="mbrn:26242504"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="663" mass="71738" checksum="A01BD1F6DF3D142E" modified="2021-02-10" version="1">MSGKVTAVGIDLGTTYSCVGVFDQEKCEIIANDQGNRTTPSYVAFNDTERLIGDAAKNQVTKNPENTVFDAKRLIGRKFSDADVQADMKHFPFKVIDKSGKPTVEVQYMGETKTFTPEEISSMILMKMRETAEAFIGETVNNAVITVPAYFNDSQRQATKDAGLIAGLNVLRIINEPTAAAIAYGFDKIRPEDKDRDDIPERNILIFDLGGGTFDVSLLAVAGGVFEVKSTAGDTHLGGEDFDNRLVNHFVNEFKRKHKKDLTTNSRALRRLRSACERAKRALSSASQTSIEIDSLMENIDFYTSITRARFEELCQDLFRSTMQPLDRVISDAKIDKNQVDEIVLVGGSTRIPRVQKLITEYFNGKQPSKSINPDEAVAYGAAVQAAILSGYNSQTTSSILLLDVAPLSLGIETAGGMMTKLIPRNTTIPTKKSEVFSTFSDNQPGVLIQVFEGERQRTKDNNLLGKFELTGIPPAPRGVPQIEVTFDLDANGIMNVSAVEKGTGKSNKIVITNDKGRLSKEEIERMLADAEKYKEADEAEGRRVGARNALDHYASNLRTTLQEPGVDEKLDAGDKEKLAAAADISSWLDQNEQASADEYEAKQKEIEAIANPIMMKFYGAGGQAGGMPGGMPGGPGGPGGFPGAGGAGGAGGDDGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWG3</accession>
    <name>A0A7D5UWG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial 2-oxoglutarate/malate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g039680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547321.1">
        <property type="nucleotide sequence ID" value="XM_014691835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWG3"/>
    <dbReference type="GeneID" id="26239884"/>
    <dbReference type="KEGG" id="mbrn:26239884"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="35310" checksum="D0A18578C55E372F" modified="2021-02-10" version="1">MAGGSLKQAAESARNKTTEVMGVARADGAAVAHDLLHTPWMRAALPFINGGLSGMVATTVIQPVDMIKVRIQLAGEGTSGGPKTSPIAVARQIVASGRVLDLYTGLSAGLLRQAVYTTARLGFFDTFMGSLTTRAKSQGRDVGFGDRATAGLAAGGVAAMFGNPADLALIRMQSDGLKPLAERKNYKSVIDALSSIARSEGVGALWAGAAPTVVRAMALNFGQLAFFSEAKVQLKKNTDLSVRAQTLSASAIAGFFASFFSLPFDFVKTRLQKQQKGPDGKLPYKGMADCFTKVARQEGLLRFYRGFGTYYVRIAPHAMVTLIVADYLGWVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX69</accession>
    <name>A0A7D5UX69_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome assembly protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ria1</name>
        <name evidence="12" type="ORF">G6M90_00g056510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544242.1">
        <property type="nucleotide sequence ID" value="XM_014688756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX69"/>
    <dbReference type="GeneID" id="26242654"/>
    <dbReference type="KEGG" id="mbrn:26242654"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000746">
        <property type="entry name" value="Ribosome assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="444"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117879" checksum="F5CE3A7494B66297" modified="2021-02-10" version="1">MPVVTPEKLASLQRQSRDIRNICILAHVDHGKTSLTDALLATNGIISPKLAGKIRYLDSRPDEQLRGITMESSAISLYFSMLRRAAPEAAPEAKEYLINLIDSPGHIDFSSEVSTASRLCDGAVVLVDAVEGVCSQTVTVLRQTWTEKLKPLLVINKMDRLVTELKMTPAEAYVHISKLLEQVNAVLGSFFQGERMEEDLNWRERMEERVNAAVAAKASADEDFSSDAGELQFEERDDEDIYFAPEKNNVIFSSATDGWAFTCRQFASLYEKKLGIKRGLMEKVLWGNFYLDPKTKKILGQKHLKGRNLKPMFVQLVLEPVWTVYQATCGGDNGKVDPSLLEKVTKSLSLTISPHVIRARDPRLLLTTVFASWLPLSTALLVSVVESLPSPPAAQAERVPDLIEQSPGSGAVDRSIKEAMVSFKREKSDPVVAYVSKMVSVPESELPENKRKPGQMSGEEARDMARKKRAEAARAAQEANGDALDGLTQALDGAHINDDEPGEHRADPEHLIGFARIYSGTLSVGDKLYVIPPKWSPAEPKAEPQPQEITVTALYMLMGRNLEALESVPAGVVFGIGGLEGKILKSGTLCSKLEGAVNLAGVSMAGKPIVRVALEPVNPADLDKMIHGLGLLVQSDPCAEYEQFGSGEHVLLTAGELHLERCLTDLKERFARCDIQAGEPIVPYRETIVRVDEMRPPVNKDLGRGAVVGTTTSKQVTISLRVRPLPPDVTDFLLKNADAIKRLYTETKPGESGEEQEQEQPDGQEDKIVADTAVTAVDSLSIDELRKQLQKQLETGKGRDVWKNRVDSIAAFGPRRTGPNLLIDATKNSILPKAFGTEARETTRAPRAGEALDPSHLSDKITYAFQLATAHGPLCNEPMQGVAVFIEDVSLDGGGGEDDGSARDKLSRLTSEVIKTFQASLRAGFLDWSPRLMLAMYSVEIQASTEVLGRVYDVLTRRRGRVVAETMKEGTPFFTVRAVLPVAESFGFADEMRKRTSGAAQPQLVFTGFEVLDQDPFWVPFTEDDLEDLGELADRENVAKRYMDRVRRKKGLLVEGRNVATDAEKQRTMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY30</accession>
    <name>A0A7D5UY30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g064690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540075.1">
        <property type="nucleotide sequence ID" value="XM_014684589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY30"/>
    <dbReference type="GeneID" id="26247111"/>
    <dbReference type="KEGG" id="mbrn:26247111"/>
    <dbReference type="OrthoDB" id="2113314at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056825">
        <property type="entry name" value="Agd3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056826">
        <property type="entry name" value="Agd3_CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056827">
        <property type="entry name" value="CBM87_Agd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25117">
        <property type="entry name" value="Agd3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25115">
        <property type="entry name" value="Agd3_CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25116">
        <property type="entry name" value="CBM87_Agd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028868362" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 CBM87" evidence="3">
        <location>
            <begin position="26"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 deacetylase" evidence="2">
        <location>
            <begin position="251"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Agd3 C-terminal" evidence="4">
        <location>
            <begin position="621"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="75265" checksum="D7A423C38D92ED99" modified="2021-02-10" version="1">MRHHASSRYLALLGVAVRFVAAATTVTSTALIIAANDADVAKASLGLDAYGIPWTKALIPQAGGSLPALNSTATNGNYGSIVVLDSVAYDYNGTYRSALTTDQWNQLYSYQSAFHVRMVRLEEFPGPEFGTTALGSCCNNNQEQLVSLNSSTPFPGANLKTGATVSTVGLWHYPAQITDSSIATAFAVFAPATGFSTESVAAVINNISGREQMVWFLDFAPDWSATSSFLQHTYIHWMTRSLFVGKRKVYLNTQVDDIHLETDMYLPANTTFKLRPGDLDAHVTWQKSINSRLPAGSDYRMELGHNGNGDIDSSIDEDTSTPRKCNPNQAVDYVQPPDPPLEFVKPPGTGVDLWPSRFVTYTWSKACASIDPLAAWFLTAANLNSFAHVSHTFSHEELDNSTYHDATREISFNQAWLAQMGISQAQRFSPQGLIPPAITGLHNADAIKAWTDNGIKYAVGDNTRPILVNQQNQYWPLASTVAVNGATGIWIIPRWATTIYYNCDTSDCTLQEWKDTSAGSGTFSNLLDNARTTNSRYLLRLQADPYMFHQANLRQTDMPSITVGSQTGKMSLIMSWVETVAQEMVRLTNWPITSLKHDDIATYFINRMTLDACQPHASYTYSADGTSITAITVSANNAACSVPVPVTIPSGTVSASGGSPKSDNLGNEPPIVWVTLSGSPVTLTLSTPVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYD7</accession>
    <name>A0A7D5UYD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g060830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544650.1">
        <property type="nucleotide sequence ID" value="XM_014689164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYD7"/>
    <dbReference type="GeneID" id="26243062"/>
    <dbReference type="KEGG" id="mbrn:26243062"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="469" mass="54096" checksum="F1D178BBFBB6F0F5" modified="2021-02-10" version="1">MWMQGDDVAWEESDRIEREWRESVLTTPTMLAIGNFVAKHRQGVPQEIGPLKAGAFNALFRLTYLDGGSAVIRFAKPGRTMFPEEKIRNEVATIRYIQDHTAIPVPFILHWGTREESPLGIGPFIIMDYINHEMNMTAALNTPGLTLDIPPVLDPNIDEAKLEMLYRQVASILLQLSKLELPLIGALEETHEWSWEVTRRPLSMPMNELVRTGTFPRAKLPTSRFNTSSEYFQALAKLHVDHLTSQRNDAIESRADCQRKYTARQLFQKLARERKLVSDRHDKGPFRFWCDDLRPSNILLDANLQIVAVIDWEFSYAAPSEFTFAPPWWLLIEQPEYWENGLDDWVQQYERRLATFLKAMVDCEDASIAAGQLLQEQRLSGEMRESWASGDFWTVYAARRNFAFDGVFWEKLDPRFFGPDKGDSDPGDAWMKRLELLDEQARAAMEAFVDGKVAESETRELAWEPDEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYV0</accession>
    <name>A0A7D5UYV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran-binding protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RANBP10</name>
        <name evidence="5" type="ORF">G6M90_00g076290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545472.1">
        <property type="nucleotide sequence ID" value="XM_014689986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYV0"/>
    <dbReference type="GeneID" id="26241505"/>
    <dbReference type="KEGG" id="mbrn:26241505"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="196"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="475"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="702" mass="77413" checksum="B45E71AFD7AE4C49" modified="2021-02-10" version="1">MASLEQHGSSGFSDSESSAGSSGRPHSRNDSRNAAAYTPEPPHRSGASSHFYTHPSRTSILSPSRGLLLDPVPGLASATSRRETNNINDSSLNDLATMWKASGTLPSFSRGFDMFMAPMCSESSDPAAKDHDSFFVPSYLSESTYVHKLEAAHRARLQARNEALKEHSHEMATELARDQPGLRIYPTSLSTGPGLPRTSLERLSWPKLEDELTPLPSRWNPGDSWGSIEFLEAARSLKFVGPRSHQDRDHEAAAARADHPMPAECGIYYYEVQILCGKRDDATIAVGFATKDATMSRPVGWEENSWGYHGDDGRCFSGTNTGRPFGPTFSTGDIIGCGVNFRDHTAFFTKNGVKIGVAVNDVVRTKIFPAISLKKPGEHIIVNFGQTPFVYDIDDMMRGQRRKIQDEIEKTDVSRLESGLGETDLIQALVLQFLQHDGYVETARAFAEDIKLQKEALNLDPNVTVDGINIKDDEDAINRQKIRKAILEGNIDRALKHTHVYYPRVFEQNAQVHFKLCCRKFIEMVRKTAQLRSAIDSKMSNGHRPGSSSISQDMDVDVNGGDDVAWNEHTNFEADMQNAHFELLKLEEEMLSYGQTLGATYARDPRIEVSKALEEIWALVAYSNPVVEPTVSHLLDKKGRVVVAEELNSAILASLGKSSQASLEKLYAQTSVLLEDLRADGGAGAFVSVQDVVGSIKADPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZW1</accession>
    <name>A0A7D5UZW1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545312.1">
        <property type="nucleotide sequence ID" value="XM_014689826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZW1"/>
    <dbReference type="GeneID" id="26241345"/>
    <dbReference type="KEGG" id="mbrn:26241345"/>
    <dbReference type="OrthoDB" id="10507457at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="215" mass="23445" checksum="1A6E23B08451E0DE" modified="2021-02-10" version="1">MPKQKGQQSQPAAVQRRPAPPLSAEGPPTPVLDSVPQCIIFGGENQVGKLPVRLFDGRDWTCREAMKPCDFLPKENVTSCLYLGKNVDLPAALVFFEYVQLPQITNKEGGSERVFKLTAAKAFPERPFGIEVDINAMSQLQVIAWNFQMLDLAACAKGWIEKKYYSPASLPVASGTSSQKPAAGGKPEQSSNVEQPDDDEESDDDDKTVIFSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0K3</accession>
    <name>A0A7D5V0K3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ran1</name>
        <name evidence="10" type="ORF">G6M90_00g069610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540713.1">
        <property type="nucleotide sequence ID" value="XM_014685227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0K3"/>
    <dbReference type="GeneID" id="26246586"/>
    <dbReference type="KEGG" id="mbrn:26246586"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000549">
        <property type="entry name" value="Protein serine/threonine kinase (Ran1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="502" mass="55979" checksum="037E3F80F0ED488B" modified="2021-02-10" version="1">MQHHAPFGYPTPPASPAYDNLKCGNNQQIFSQTAFQSRCVPLAPEQRLGRFLEGKLQLTEVLGTGAYGVVYSAIDIKTGVRYAVKCLSKYNADGTPLERRQVAYQQREIRLHYLASAHPNIVSMLKIVDDPDCIYVILEYCPEGDLFLNITELGQYVGKDLLSKKIFLQILDAVEHCHKLGIFHRDLKPENILVTDNGNTVKLADFGLATADDRSEDYGCGSTFYMSPECLNPSSRKPYYMCAPNDVWSLGVILVNLTCGRNPWKQASCQDSTYRAYTRSQDFLKTILPLTDDLNDILGRIFHPNPELRITLSELRCRVMACSQFTVPAAQTMSVQQQSVSPHIPEYVTDEDAIVDDYEYDSPLSPASTTSDEGSLTSSGSTIDDLDDDDFAQEQHDIPVAFAPATYDAEDAGDLGMYQDQCIPPTFHDAAVPIPMQVPPQPVVCQQAPVPIQVPVPVQAPCQPKSFFPLWEVVRYVQQVPMMQHPVAFQQVPFIPSFQGCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0X3</accession>
    <name>A0A7D5V0X3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemiasterlin resistant protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">har-1</name>
        <name evidence="2" type="ORF">G6M90_00g089770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541637.1">
        <property type="nucleotide sequence ID" value="XM_014686151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0X3"/>
    <dbReference type="GeneID" id="26245500"/>
    <dbReference type="KEGG" id="mbrn:26245500"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="151" mass="15626" checksum="D33882451796E8FD" modified="2021-02-10" version="1">MPRNRSVGRAPAPSRAPTRPTVPASNPMPQQQRPATTMAAPPQHAPQQMAPAPAASQGPGLFGQMASTAAGVAIGSSVGHAIGGLFSGGSSEPAPQPVQAQASQQQQQWGNNCQAATQQFTKCMDDNGGNMQICNWYLEQLKACQAAASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Y4</accession>
    <name>A0A7D5V0Y4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BGLR</name>
        <name evidence="3" type="ORF">G6M90_00g089900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541649.1">
        <property type="nucleotide sequence ID" value="XM_014686163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Y4"/>
    <dbReference type="GeneID" id="26245512"/>
    <dbReference type="KEGG" id="mbrn:26245512"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028958139" evidence="1">
        <location>
            <begin position="19"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="417"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="536" mass="58252" checksum="B5F6E5865487529B" modified="2021-02-10" version="1">MSRSYILALLSALTRTAAETYNIPSNPTVSGQPFDSFVSYSIEFSSFPDFAGNHSHPNKYSYNLINNIHAISNNYPVIRVGGNTQDFALYNASQPTSLVGVVDPDKSPDYPTTITIGKSYFESYRTWPGVRFSHGFNMGLGGKTARGRETLVDTAPLACEALRHGNLYTWEYSNEPDLFTSGTYAPRPKGWSETDMVAEWLAGTDEIRNQVKKQCPEIQVSFIAPSNAGVSNALKASKMWAAGLNKRGDIAMFSTHNYIDGAKVPGVTLQGTLMNHTRTKLSVNNHVAEYNSIFRAAGSPPPLIFGETNSLYNQGRPGLSNTFGAALWCVDFNMYSAAVGFKRVHMHQGTNYRYQAWQPVATDLAAIGTKAPYYASITAAHMTRRAARAPVSISHVPLSSDAAESAYAAHCASRSGEKHLARLMVVNMHGYNTTVGGAGLEPLPSPPPRTVRKYKFRVEGVRDGVRASVHRLMANGSDAITGITYDGWSYNYDLDEGRGVRLTNVTVGEKIIVEGGEVVVHVADSSAVILSFATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1K7</accession>
    <name>A0A7D5V1K7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein atp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atp12</name>
        <name evidence="6" type="ORF">G6M90_00g090090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1K7"/>
    <dbReference type="GeneID" id="26245530"/>
    <dbReference type="KEGG" id="mbrn:26245530"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="366" mass="40488" checksum="C802EE43A385C70E" modified="2021-02-10" version="1">MRPTTQLPLRAVSRIISTPIHTRPLHATTYKAASVASVLGTGPPPEPPTAAVRNMNERIERRRKQADLLKQAKVIRNAKDGKTTALRKRFWKDVSVQEVDGALQVHLDTRPLRHPQTKEVIRLPLSKPNLAFAIALEWDTMTSSLQATKQHFIPLTSLACRALDIEKDDASSAPGAATIRNDITTSVLRYLDTDSLLCWAPPAGEYDLRNDAGESLRDVQKRTTDEIVSFMTTHVWPGIRLEPVLDGHAIMPRKQDDGVREVVQGWVSGLSPWEMAGLERAVLAGKSLVAAARFITEWSEGPVRKPNLSGHVQFGVEEAAKTVSLEVDWQVTQWGEVEDTHDVNNEDVRRQLGSVVLLVSGTGKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1X9</accession>
    <name>A0A7D5V1X9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543406.1">
        <property type="nucleotide sequence ID" value="XM_014687920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1X9"/>
    <dbReference type="GeneID" id="26243583"/>
    <dbReference type="KEGG" id="mbrn:26243583"/>
    <dbReference type="OrthoDB" id="4941312at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028849731" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14763" checksum="4511A13D9C182705" modified="2021-02-10" version="1">MKYSFIVAATGFALSLAAELQPWKSGPGGTEQECKKLSLQKARECFDSHEARPDTEPKLPWQDGEWKANPRQFKLCNDTHPNPNFKFRPILEQFCGTEIYCNLFDQDKTRVDGLFKSTEHCRQSHEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2D5</accession>
    <name>A0A7D5V2D5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g084510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543666.1">
        <property type="nucleotide sequence ID" value="XM_014688180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2D5"/>
    <dbReference type="GeneID" id="26243843"/>
    <dbReference type="KEGG" id="mbrn:26243843"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="193"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="691" mass="77233" checksum="B8DD8DB573807C63" modified="2021-02-10" version="1">MNQEQDFCDDSENTGLPAHVHHDTGTAIDTSPDFMQTQPFDIEFLSNETGMLNDYLLDIFPHIDYQEVAFKDDSRHDGGTEAPAEAPNSNTHVSPDVIQAGGPPRQSDNVADQSRVVDHNPSSTRHMDEEHSRVNKTLDAIDDIVPTNPWSISTAAYDRLAAEVMKHKHVLPSPYTLPSRHRLSRFVASWIRGFHPHLPFLHLPTTSLDSMTPMLLLTLAATGSFYGFEHTHGYAMYFVAKSIITEELEKRRQTANLYLLRSFPRYARLPTSPQSATTFQPTPPATIDMELLQCLLVLVLTMSWLDGPLAQNALAMSSQLASLTRESLACLHLTGNNDNWVDWARDEERRRTIFSAYFVLNIQTICFNVPPQIAVSEMNLPLPCSEAEFKASNSKAWCRLQKKNPRRPVFAHCLEQLLSGRPLDKQGPVTEFGNYMLLQGLLVQIYFERQAASTLVNPTSSLPTSTISLYDSAIDAWESCWDPAIESALDPSASSHGPLAFNSTAMLRLAHIHLAVGLQCQCALRSRNPRVIAQAFEAHNPIPLRSPHLDQAASHAIYALRIPIRVGIAFVARGRTGHWSVQHAISNFACALFLAHWLENIFGLVSSNPDGLEGLRSEEKRLLFTIERLIEETDLEDSLGPKDLYPSRIRRLAVAVVRLWAETCTGIQVFEIVHVIGETLTLVAEMIESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2N1</accession>
    <name>A0A7D5V2N1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="5">ARD'</shortName>
            <shortName evidence="5">Fe-ARD</shortName>
            <ecNumber evidence="5">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="5">ARD</shortName>
            <shortName evidence="5">Ni-ARD</shortName>
            <ecNumber evidence="5">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ADI1</name>
        <name evidence="6" type="ORF">G6M90_00g088580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="5">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="5"/>
    <dbReference type="EC" id="1.13.11.53" evidence="5"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987498.1">
        <property type="nucleotide sequence ID" value="XM_066131333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2N1"/>
    <dbReference type="GeneID" id="26244771"/>
    <dbReference type="KEGG" id="mbrn:26244771"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0533">Nickel</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="424" mass="47804" checksum="1CFFC836F1DBAB18" modified="2021-02-10" version="1">MKAYMYDNQPGDQRLPHDSGRAISTEALGKLGVLYFHFANIADVDRLAADRGYKNRDEITVSPEKMGGMYEDKVKMFFNEHLHEDEEIRYIKGGQGFFDVRSKDDNWVRVRLEKDDLLILPAGIYHRFTTDEANIFGGTGHMGRSLVKYALSRGDLVTSVGRIHESNIDDIANIHHDNCLGALCDVRSRDSVAKVVQDALDRFRRFDVVANCSGHGVIGSCEDQDEHDLRNQFETNFIGTLHIIHTTLPYFRRQNSGRYLIFSSTSGALGVPGLGPYCATKYAVEGLIEAMLYETDSFNVRATLIEPGLVRRDEPDTGDSPLPTWGHFLIKPSSNGYGNATSPALHARRMVQWLGDRQPTSAVKCAELVWQLAHCTYPPLRLLLGSYAIESIRDRMRSVTEELEDWKHLNFATAGQESERDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3E4</accession>
    <name>A0A7D5V3E4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g092520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of a SNZ isoform.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541895.1">
        <property type="nucleotide sequence ID" value="XM_014686409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3E4"/>
    <dbReference type="GeneID" id="26245363"/>
    <dbReference type="KEGG" id="mbrn:26245363"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000042">
        <property type="entry name" value="Pyridoxine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="12">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="55"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI72579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="23915" checksum="2A4F2E9EC56A178C" modified="2021-02-10" version="1">MILLTIGVLALQGGFIEHINLVRKAADRLKLHVSVIEVRTAQELARCDGLIIPGGESTTISLVAAQSGLLEPLRDYVKVQKKPVWGTCAGLILLSDQANATKKGGQELIGGLGVRVHRNHFGRQTESFEADLDLAFLGDDAAPFPGVFIRAPVVEEVLGDGVEVLATLPGRLDRAAAGVSQANAKHGSGDIVAVRQGNVLGTSFHPELTGDARIHAWWLRSILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3K7</accession>
    <name>A0A7D5V3K7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">V-type ATPase assembly factor pkr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pkr1</name>
        <name evidence="3" type="ORF">G6M90_00g099710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546378.1">
        <property type="nucleotide sequence ID" value="XM_014690892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3K7"/>
    <dbReference type="GeneID" id="26240801"/>
    <dbReference type="KEGG" id="mbrn:26240801"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="156" mass="16785" checksum="94A4F96E0D948AAE" modified="2021-02-10" version="1">MAAFITDLWESIFVPGPTPTILKATNATFAALQIVLFGLLVATASIHFVILSVLCAGLWYSINWFANEVAVAQKRQQEEAEQAKAKEEDATDDKGGDDSDTEVETTAREGRQRLKKRGETGGAAGQAKNSEVSSGGSTQSSVSTEDEWEKVSKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3W8</accession>
    <name>A0A7D5V3W8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g102130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546133.1">
        <property type="nucleotide sequence ID" value="XM_014690647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3W8"/>
    <dbReference type="GeneID" id="26240556"/>
    <dbReference type="KEGG" id="mbrn:26240556"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="50175" checksum="8D15D4D48663D5FF" modified="2021-02-10" version="1">MALSIRQLNGDASFLLTFEPVESGPPDGASMPELFRILLDPWLVGPSNIFHSKFSSTTHVQGACVSTLRDLPEPDLVIVSNGRSDHCNEATLRQLAPRGTKTIILAEPTAAKQIRSWKYFDDRKILTLQRWQDPRQTGRDTVIRIPIRSGTAGGHKGLVTVSFISRGRSTKGIDSAIGITYRPAPLGLSISQPPATTASTPLSTPSLDFASRTTSPSELYTPEAIETPTLPPLPALPTLTPTESPAAHSSKAGRSLTTLSHPQNRSVSGVSVIFSPHGISYSAIEGYATSHLVSEAALPLTALLHCFDAVSQPWWLGGNVTSGFHHGQEIIAKLGARAWISTYDGDKFLRGLARRLTRRKKYKTHEVRNSVHGATVGFHNTRKPSSRRCGKMDRPTEIMALNIGEEIALTSDGVWATEAASSMGSGYLNRRLSIPHLLYANASGESISSPFRVSKLWPSMFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3W9</accession>
    <name>A0A7D5V3W9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DCW1_8</name>
        <name evidence="14" type="ORF">G6M90_00g111940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540266.2">
        <property type="nucleotide sequence ID" value="XM_014684780.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3W9"/>
    <dbReference type="GeneID" id="26246860"/>
    <dbReference type="KEGG" id="mbrn:26246860"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028910020" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI74616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="459" mass="49439" checksum="744AD2201A2DC981" modified="2021-02-10" version="1">MRRQILLSVIATVFTTGGSAQATPFSLDSDDAIKQSASTLAWDMMQYYKGNLSGQTLGILPGPPPAGPYYWWEAGAMWATLIDYWAWTGDASYNDEVMQAMLWQVGPNDAYMPPNVTASLGNDDQGFWGMSAMTAAEMKFPNPPSDKPQWLALAQAVFNTQASPDRHDGSCGGGLRWQIPFANNGYNYKASIANGCFFNLGARLYRYTGNTTFSHWAENTWNWMEGVGFLDSATYAIYDGANVGDNCTDINKAEFSYNNGIFALGAAYMYNTTKDQVWADRVTKLVNYGLKTFFPGGIAVEITCEDEGTCTTDMITYKGFMHRWYSYITQLAPFTANTINPVLKTSAAAAVKQCTGGAYGRQCGFRWASGKYDGTTGAGQEMSVLAAVSSQLINVAGKAPVTADSGGISTGDPNAGSGADNFQNKTRPVTTADRVGASIVTLLLLAGAGVVFGSMVMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4K8</accession>
    <name>A0A7D5V4K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PHB2</name>
        <name evidence="10" type="ORF">G6M90_00g097740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546568.1">
        <property type="nucleotide sequence ID" value="XM_014691082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4K8"/>
    <dbReference type="GeneID" id="26240991"/>
    <dbReference type="KEGG" id="mbrn:26240991"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="9">
        <location>
            <begin position="59"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="310" mass="34110" checksum="799C2C6F89BF19B5" modified="2021-02-10" version="1">MSGQNNWQEEAMRRLRQMQSRGGYGGRPGGGPPQVPRGAGGALIGGVLLAGGAWVLSNSLFNVDGGHRAIKYRRVSGVSKEIYSEGTHINIPWFETPIVYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPQVEALPQIYRTLGADYDDRVLPSIVNEVLKSVVAQFNASQLITQREMVAKLVRENLSKRAARFNILLDDVSLTHLAFSPEFTAAVEAKQVAQQEAQRAAFVVDKARQEKQAMVVKAQGEARSAELIGEAIKKSKAYVELKKIENARLIAQQLQESGSKNRLMLDAEGLGLNVFEGEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5V7</accession>
    <name>A0A7D5V5V7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Siderochrome iron transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sit2</name>
        <name evidence="9" type="ORF">G6M90_00g108100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544035.1">
        <property type="nucleotide sequence ID" value="XM_014688549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5V7"/>
    <dbReference type="GeneID" id="26243422"/>
    <dbReference type="KEGG" id="mbrn:26243422"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="608" mass="66919" checksum="5F6941B394BA23CA" modified="2021-02-10" version="1">MHTTKNADPRTPGQAGLFPPADAAEEFKSKPGHGHGQEAFPSDADNASLEEKNEREVQQHPQEVTASAELGVQKAEAAALVWTKKTVYCTYAWIWLCFFMLAFQQAILFNVTATAYADFASAPAIATASILSNIIGGVLKLPIAKTLNIWGRAEGYLVFFGVYLLGMVILASSGGPDSYAAGYVFYWIGYDAIYLILDIFVADTSGLQNRAFAFSFVSTPFICTAFTGPLAAQAFLRHSTWRWAIGCFAIIQPFVFVPLAVVFKFYQKKAERLGIYKHQPSGRTALQSVLHYVHEFDVVGAVILMAAFVLFLLPFSLVSYGRATYASATFIAMVVAGIVLFPVFAAWEKWFARTHFIRWELFRQRTVLGACCMAALSFFSFYSWDLNFYSFVLVVYNLSYSDTGYMTQIYNVGSCFWGVVFGLWVKYTKHFKWTVLGFGLPLMILGAGLMIHFRGQDADIGYIVMCQIFIAFGGGTIVIGNSMAVMAASDRDGVPMMLAVLNLFASIGGAIGDAVSVAIYSSTFPEALRSRIPQDMADQVDKIYLGGYLAQVTYPVGSPTRDAINYAWGQSQRYGSIAATAILTLGIPAIAIWKNYRVDKKQNKGTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5W9</accession>
    <name>A0A7D5V5W9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthetase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NPS6</name>
        <name evidence="6" type="ORF">G6M90_00g111650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543702.1">
        <property type="nucleotide sequence ID" value="XM_014688216.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243089"/>
    <dbReference type="KEGG" id="mbrn:26243089"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="711"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1384"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2467"/>
            <end position="2543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="3009" mass="331668" checksum="5C1ECD53EBC2CD87" modified="2021-02-10" version="1">MAADIVLRPCHVMVNWQSTVSDYLSSISDSMLRTEELGEFCDNVKKAGDGCGGPCKLQELEFGTTFVVLDGSMNSTIGEEHQTLWNRDEFVVECVRSGGQRITLRCHANRCQDDVISLDRVALQFEHIARQLCASGQKDEMPLFSQQKLSDLGLVCFQDKSQIWKWNASVSRTIDCLVQDMFLEIVKVHPHRIAVDAWDGALSYSQLDEKSSALGLLLSTRNIAVAGQVVPLYFEKTVWTTITILAVAKAGSIFVLLDPQQPTERIKSIIDQLGVSCILARPETLARAQSLAARVVVVDDALLRGHVCSKALSPPSVIANVNPAQTLYIVFTSGSTGQPKGVQISHRNLCSAVTYQARELGFTDARTLDSSSYSFDAYVFNTFYTLLSAGCLCVCTDVDRMNRLQSVLQDQRITLVQLTPSLAQVLDPASLPHLQTLILTGEKLGQTVLGAWICSARTRLINAYGPTECTIMCAANLNVDGIENLDSIGQGIGATLWIADVNNINRLAPIGAIGELVIEGPLIGLGYLGDENNSYGSLIDPPDTGYLAGVTRAPQAKLFRTGDLARYNGNGTISYIGRSDTQIKINGQRVEVSEIEHWLGQYWPHDSSPVVEAIHWPSGVKQLVAFVVQNGEQFAARQRLRDLITQGNSALASHLPRYMIPSAYFPLQHIPMTASGKKNRRALRNLALGAPDELLEAVTGKQVEDSMGAVREMSDHELRLRQVWAAALHADESSVQLHDNFFAKGDSLAAVKLISLAHKQGMMDLTVADVFRHPKLVDLAAQAGTKAEQPQAQLLDLNPFSMLAGTSNEVEILRAEISKMTGCGASQIQDAYLCSPIQEEMMALAAMRPRDFITHEVLRLPDNIVLSRLLDALQQVAVQLPILRTRILDVGFGGEHGPSTLVQDVIDEPVPLSWYMTLEACLVSEKNKAMELGDALFRLGVVKPDLPGSTAKKEHCVVLVMHHAIYDGWFLNLLMQGMKKSYEGDYDAPLLPYRNFIQYLISNEHKKSADFWLSQLNNTRIKPFPVYPSLEYKPSPGALCDHCIPLIPWNKASNVTPSTFIQAAWSILLASYSGSSSVVFGTTVLGRQIPLTGVERIGGPTIAAVPICIQVKNSMKVVEFLQTIQMQMVEMIDFSHFGIRNMKRLSHKARMATDFRTFLVVQPPVEDTDRSFLSLSSGSEDITAFNTYALMLECSLGKDCGVRMRASFDQNILSGEQVRSMMKQLEGVLGILIIDCHSYVSDAMAIAMSGSHSAVLEQPNTSAQMEEIENSIRGSLPPEISDVAVTKIDLPLSPNPVVAFFEAHTGGKGVLERISAVYCDQARHLPRYNIPNHYLTLEQLPRSSNGQLDRISLKKWAEKFDLHQFRTFSWVPPVPCQLEGQVEGEMTDAEAVFRRLWADSLNIPMTSVHRNSSFIFLGGDSLAAMKLVAAARKSGYSTSVAQILEKPALADMAASANLNVDISAENQTPKPFSLLKPSPDPAGLALMCNVDRTDIEDAYPCSPLQESMMTRTIQRGGDYVSQGLVQLSKSVDIGRLQRAWHQVATLNPILRTRIIDWPGSGLLQVEVNKAIDWLSCDTIDDVPENSMGLGRPLIRLCIIKSMGERRCLGPGLLLTAHHAIYDRWSMSLILRAVESIYLTGTFQGKLSPYNEFIRYLVEDFDHDFAKSFWTEYLSGLSARQFPVLPSQGYQPTTDAYHNHSISSVPWPVNNTPTTVLKASWALVVSLYTNCDDVLFGMTVMGRQGPVPNSETIAGPTIATIPIRVRINWPDSPRALLQDIQSHAAMMIPAEQYGLGRIRRLNGDTKVATQFQSLVIVHPSGYAVLDDQMIGLQLGEDIEQGDSTAITIEFAVDNEPRSNQAGVALKMTYDSKILELAQVQRIACLTEHVLRQLCEHSGTDKMTLAKIDMLTRQDRETLWQSNLSVPPTCNNHLGNMLVDCISNQGLTAAVCAWDGELSNKDLSKKARRLAYTLVVCHGVSPGIVVAICSVKSVWTPVAMLAVLISGGTAMMIDPSQEAGRLKIITKQAGACLILTTTGTGTVAEQIASHIVVIDNDLSYPSSAWKLRNDDDSWIPPSSPTDSAYIIFTSGSTGVPKAAAISHKNCCSAIIHQNKALGFKGAARVLDLSSYAFDVCWEHFFQTIYAGGCICIPTDHDCVDDIATAITRLGANFLQMTPSLARTLEPSSISGIEIVMLSGEACSMHDVTRWGPAVEVRIAYGPCECTPTTMIATYGKDFLDKVNLGLPYGVNAWILSSVQPDTLAPVGGEGELVVEGPLVGQGYINSPRENSESFLSDPEWLLRGSDTTPNSGRRGLLYRTGDLVRTDSRGRLHFLGRKDSQIKIRGQRVELEEVETHVRDLLDPDLQVAVDVIEDYRGTPEIKSQSLMLFIAGNIHKSLTIGREEAAPLIRGLIKRLSTILPRYMIPSGFILLEQIPFTRSGKIDRRVLRQIGCQKQAESLRSKVPGAEPSTDIERKMAHSWAQALGISPQAISRQDSFFELGGDSLTAIHLVGIARNFQLTLSVVMIFQNPNLEDMAKRAEMDKVSNEASSNGDLVDMKHEPRFDGGPWLPKPSEVSKMLHADAQHIGDILPVTDFQAYAIRCNLAMPRTEWNYFALKFQDLEDPEPVNEDQIRRICHALVERIDIFRTIFLRHQGGYFQMLLDRVEPHVSVSRVTGSLDAACKTICQQDLTERLNPALPFIKFFIVRRQDAAEACLVIGLSHACYDGISLPYLAECIGALHDRRPLPQMSSFFSYLKDTMSQAKTTCGLTFWRSVLKGSPPPTSLSPNGADVLATNTDRCRLEHQVVARCFPKKVTAATFFIGALAVSMASVSGQDEIILGRGVSGRALAVERNHYRVIGPCLNIIPARINCQNPEKIIDMLMAIQEQFIAAVPHETLGLSDIVRHCTDWAPETQYGCVFYYQSAAEPVTRIAGHDEYLTPLQLVRADPPEPLRVDVTPRGGDDYLLEISTPSLGNRVNESRALLDCMVHWVSEWERTRPVDRMERRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6V3</accession>
    <name>A0A7D5V6V3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g107160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544122.1">
        <property type="nucleotide sequence ID" value="XM_014688636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6V3"/>
    <dbReference type="GeneID" id="26243509"/>
    <dbReference type="KEGG" id="mbrn:26243509"/>
    <dbReference type="OrthoDB" id="4936979at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.400">
        <property type="entry name" value="Calcium-mediated lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036684">
        <property type="entry name" value="Ca_lectin_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="169" mass="19013" checksum="550DB87EFC22245D" modified="2021-02-10" version="1">MTTQTTTQIFETMSVPADMLALRTVEQPFSLAVPGDAQITVTCHTNARYYQKVTVEDVANKKSWVFFGSGEDETPMEIQGSKEKGVVLLHALETEASFRTLRILCEYSSQGPSGRLEKSDVLVPQMRCEYNGPQHLKRISWEIFTEDGVDKDYNDSVLRIMAEVDKNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNC2</accession>
    <name>A0A7D5YNC2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g019790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="Fung_rhodopsin"/>
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    <sequence length="319" mass="36070" checksum="FFB794BBD0E10D45" modified="2021-02-10" version="1">MSSNIVAESWTWYALVWFVVVCRIISQILLRGSIKKLRPDDGLILFAMMTYTVLIVSINIVSDTASNLIDPEDHVVLTPESLRERRFGSKMVLIVEQMQISTVWIVKTCLLIMYYRLTLGLAQNTAVKLVAVYIAIGWIVMEVLYFGVWCRPFSGYWEVPPSNPQCATALHHLITNAVFNISSDLMIILIPIPLLLRTHWPLKKKLILCVVFGLGGFTILSAVLNKYYSFTQPYGSQWTFWYIRESSTAIIVANLPLTWTLIRRVFSVGSFRGGSGRRSSAAMRSTQTENERKHAAYNPHSAVREPSSSNQSQEVDGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPH8</accession>
    <name>A0A7D5YPH8_9HYPO</name>
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        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LEUA</name>
        <name evidence="22" type="ORF">G6M90_00g005520</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI64782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_066129595.1"/>
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        <property type="reaction ID" value="UER00071"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:L-leucine biosynthetic process"/>
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        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK01641.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="Aconitase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="547"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="486"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="755"/>
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        </location>
    </feature>
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            <begin position="502"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
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    </feature>
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            <begin position="772"/>
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        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI64782.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="783" mass="84635" checksum="19A0E7021F3E99EE" modified="2021-02-10" version="1">MPGPERNPQTLYDKVLSNHIVDEKLDGTILLYIDRHLVHEVTSPQQAFEGLKNAGRRVRRPDCTLATTDHNVPTTSRKGMKDIATFIEEDDSRTQCVTLEENVKDFGLTYFGLGDKRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQCLITKRSKNMRIQVDGELAPGVSSKDIILHAIGKIGTAGGTGAVIEFCGSVIRSLSMEARMSICNMSIEGGARAGMVAPDETTFEYLKGRPLAPKFGSDGWNRATAYWKALQSDPGAKYDIDVFIDGKDIIPTVTWGTSPEDVIPITGVVPDPETFASEAKKATGRRMLEYMGLTAGTPMEEIVVDKVFIGSCTNSRIEDLRAAAHVVKGKKIASNIKRAMVVPGSGLVKTQAEEEGIDQVFVDAGFEWREAGCSMCLGMNPDILSPQERCASTSNRNFEGRQGAGGRTHLMSPVMAAAAAIVGKLADVRKLASYKASPHVEASVTPSTSQKAHVDERVATDAHEREVIGDQPEDSEPHTNTSVSTSNGGSSTAGLPEFLSHKGIAAPLDMANVDTDAIIPKQFLKTIKRTGLGTALFHALRYSPDGSDNPDFVLNQEPYRNAKILVCTGPNFGCGSSREHAPWALLDFGIKCVIAPSFADIFFNNTFKNGMLPIKIENKSDLDAIADEARAGREIEIDLPSQLIKNSVGDTICAFDVEEFRKHCLVNGLDDIGLTMQMEDKIGEFEKKMTEDTPWLDGTAYLKRPGQGGKLAAKAVPVPKTNRGEEKKEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPK5</accession>
    <name>A0A7D5YPK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g011020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985844.1">
        <property type="nucleotide sequence ID" value="XM_066129702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPK5"/>
    <dbReference type="GeneID" id="26238863"/>
    <dbReference type="KEGG" id="mbrn:26238863"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000030">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="417" mass="45303" checksum="152B32615866A1EA" modified="2021-02-10" version="1">MPRDPLIGLVGKPSAGKSTTLNSLTDASSKVGNFPFTTIDPQRAIGYLQIDCACARHHVSDRCKPNYGACVDGRRSVPIELLDVAGLVPGAHQGRGLGNKFLDDLRHADALIHVVDASGTVDAEGKETRGYDPSVDIAWLRSEIVAWILGNLMQRWPSIRRRHVAVKATAVETLQGQFSGYGATSTVIARTLDRAAVKEPLEEWPDETVAHIVNAFVDEKFPTVIALNKIDHPDADKNISKIAKMQDPKTIVLCSAISEIFLRKMAKQGYIKYVEGSEFIDTREDLIEQGDPDGGGLKELDEKNRNRIENLKDMVLYRFGSTGVVQVLTRAAELLGLVPVFPVRNTATFSSGASESKVVFRDCVLVKKGSTVGDVAKKVMGDAPIAYVEGFGGLRVAEDDYVAVGKNDILSFKVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQX1</accession>
    <name>A0A7D5YQX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NHA1</name>
        <name evidence="15" type="ORF">G6M90_00g041590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547502.1">
        <property type="nucleotide sequence ID" value="XM_014692016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQX1"/>
    <dbReference type="GeneID" id="26240065"/>
    <dbReference type="KEGG" id="mbrn:26240065"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="466"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="816"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="994" mass="110073" checksum="2EC9F16CD6756EE9" modified="2021-02-10" version="1">MAWEQLDITKPHLVYIILGGFTSLFMLCSSFIKERMYIGEATVATLCGVIFGPHVANLIDPNSWGNTDIVTVEFSRIVLVVQCFAVGVELPKFYMEKHWKSVIFLLVPVMTVGWLLTSLFVWWMMPGLNWLDSLVVAACVTATDPVLASSVVGKGKFAKRVPKHLRDLLSAESGCNDGMAFPFIYLSLFLIQYNRNAGEVSFHFVVYVVLYECIFGAVYGFLIGYIARHGIKYAESHDLIDRESFLVFYFVVALFCAGSGSILGVDDLLVGFAAGVGFSNDGWFGEKTEESHVSNVIDLLLNLTYFVYFGTIIPWEQYNDGAFGMAAWRLVVIAIFVLLFRRIPIMMALKPFIPDVKNWREALFAGHFGPIGVGAIFVAILARAELEHDEPVPLGELPPPSAPHFALIYLVWPIVTFLVISSILIHGSSIAVFTLGKRINTLTLTMSYTAAPDDGPSWMNRLPRISSQSRSMAKTMSETSLDDLKDPEFPPGTLAPPTGFLRRQRDEEGHSRSGSRASSLVSRKRKHKKWDDGIGPGGPISQSAIFPNRPSQTEASEKEPSSPTRETTDSTMFSDEQRTEKQGETDEHGESPRDHSPQINVYDEGSHLVFENEDGDVIDMQPTPQGEQERNSKTKKEDQPASSKPEGEASSSWRHGGWRRKMSEYYTSELEKRKDKGKSDRRHEPARAYQFGNTIIVEDEDGEVVKTYELPSSKPDGQESDLIGASLKYLGLGARARPSEKNTAAAAEEGQAGVESSNKAQFKPGWAGFGQRGDGVRRKSVAQQQQDDDDDKKIRFTIGGVGRRMTKEDFIREVQKLDAGTRNEVIDQSTASNALKSIARQDAPVEPKITQSQRPVPVIREHDSESGSGSGSGSSNGESSRAAEKRSVSMSPTRKQPQVTEPPRGRRDHPSEEQGETSVERRRRLAVLTRQAEDDDKGNDDTGETPAERRRRQAALGMGGPAAEEDSDSEDEGTERVPPARKGIRFAEPQRKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRV9</accession>
    <name>A0A7D5YRV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Proline utilization trans-activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PUT3_0</name>
        <name evidence="6" type="ORF">G6M90_00g043830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547719.1">
        <property type="nucleotide sequence ID" value="XM_014692233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRV9"/>
    <dbReference type="GeneID" id="26240282"/>
    <dbReference type="KEGG" id="mbrn:26240282"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="260"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="689" mass="76212" checksum="545C40D085BE7C19" modified="2021-02-10" version="1">MKSAAGMSAKAAATHAQPSDHGNLRPVAYLRELERKAKALEAALSQRVPTSAKTKHGAPGEDEEDFEDEQPLLEPFTNLSLHRPSTSFLGPASSDIFLRNVRKLSGFYGDDGSLDASSNFYEPGALASRRQFFRLHVRLPPIEMARRLFAAQYTYIGTIFAFTDPKEEFDRLLVEAYNGPPDPSDKDACLAYSKVLLILAFGQLYSVNQWVDFRGPPGFDFFTDSLQLLPETHEEGSILCVETLALAGYFMQNMNRRDAAFQYIGKALRMAISLGLHQEVSNHYPNATCQGQVPALDEAAREHRRRIWWSIYSLDRILSVKSGNPIAIQDEDIGVNLPSRLPSEPEYCPAVVLRYYTQLSGILGEIHTLIYRRTNQAVPKSGKSLMASVQSIILALSKWNREVPNELRFDPIKLSFSRESVSYLAHYYQCINMTVRPLLFHVVQKRLNTIRSGGGPQEKERDWKEGLSQTTVRVIDMCIGAAQDTVNMMAIASQRDLVATYGYMDGEHIFSASIVLVMVCAAFPTNIANTTAMNAGLSLLRGMGERGNSHMGARYELLAKLHSGVMPGAVIRCTTATGSPPHGTDFDSAITGSASSMATDRLPARVPMPAMGSINKVDGAAEQTLTFPVIDNSSLDEPFYDESVTSGMDFGLWEEGFAYPTMDLDFDLVQRQPQGQVHSAIGEFMYMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSE0</accession>
    <name>A0A7D5YSE0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">hts1</name>
        <name evidence="17" type="ORF">G6M90_00g046440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544770.1">
        <property type="nucleotide sequence ID" value="XM_014689284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSE0"/>
    <dbReference type="GeneID" id="26242111"/>
    <dbReference type="KEGG" id="mbrn:26242111"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="69"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI67661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="532" mass="59350" checksum="289389843D6B0222" modified="2021-02-10" version="1">MLPALNRRIYRIPVVRTGHPLGTLFLRSFTASPLRRRFAATFAHDEDDMATPDGKVPKASAVTLKTPKGTRDWSGQDMLLREEVFKMITDVFKKHGGTPLDTPVFELKEILSGKYGEDSKLIYDLQDQGGELCSLRYDLTVPFARWLAMNNIQAVKRYHIAKVYRRDQPAIARGRYREFHQCDFDIAGVYDPMIPDAEVLRIIVEVFEALELGVTIKLNHRQVLDGMFAVAGVTPEKIRTISSAVDKLDKMSWEDVKKEMVEEKGLASEVADRIGEYVRHAGTISETLQLLKSREELVANEQVKRGLDDMTLLASYVEAFGIADKISFDLSLARGLDYYTGLIYEVINLPPKAEEGQASGKKSKKDDPASQVGSIAAGGRYDNLVGMYGKRQIPCVGISFGVDRIFTILEARRRKDGLKQRRDVDVYVMAFGDKSSNGLLLERMSVAQRLWSAGIRAEFSPKVKPKLPQQFKAAEGVPLGVILGQTELDAGQVRLKLLGQGENKGDDKPAEKDDGKLVSLDELADEVKKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSY9</accession>
    <name>A0A7D5YSY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL10</name>
        <name evidence="4" type="ORF">G6M90_00g076790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545424.1">
        <property type="nucleotide sequence ID" value="XM_014689938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSY9"/>
    <dbReference type="GeneID" id="26241457"/>
    <dbReference type="KEGG" id="mbrn:26241457"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="219" mass="25203" checksum="9CF858BFFD502C22" modified="2021-02-10" version="1">MARRPARCYRYCKNKPFPKSRFNRGVPDPKIKIFDLGRKRANVDDFPLCIHLVSNEYEQLSSEALEAARICANKYLVKHSGKEGFHLRVRAHPFHVVRINKMLSCAGADRLQTGMRGAWGKPNGTVARVNIGQIIMSVRTRDSNRHLALEALRRSQYKFPGRQKIIISKNWGFTPLRRDEYLERKAAGRVKVDGAYVQFLSNRGSLEQNMRRFPDAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT76</accession>
    <name>A0A7D5YT76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucans biosynthesis glucosyltransferase H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">opgH</name>
        <name evidence="15" type="ORF">G6M90_00g045750</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; osmoregulated periplasmic glucan (OPG) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family. OpgH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544702.1">
        <property type="nucleotide sequence ID" value="XM_014689216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT76"/>
    <dbReference type="GeneID" id="26242043"/>
    <dbReference type="KEGG" id="mbrn:26242043"/>
    <dbReference type="OrthoDB" id="3717264at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003962">
        <property type="entry name" value="PRK05454.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF5">
        <property type="entry name" value="GLUCANS BIOSYNTHESIS GLUCOSYLTRANSFERASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028829859" description="Glucans biosynthesis glucosyltransferase H" evidence="13">
        <location>
            <begin position="20"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="165"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="560" mass="62786" checksum="AD900934F5AE233A" modified="2021-02-10" version="1">MFRPGGITLLEAFILFCASISTPPHVIYFWNCIIGLCVDAFGNPEKSIYPYFDAKGPLPEITSQTALVICLCNEDPAPILSRLHAMRQSLLQTGRLEYFRFIILSDTSRPDVMEMEDKGFADLAKSLGVGMSRAPLYRRRIKNTGYKAGNIKDYVDNHSEGDDLFVTLDSDSAMGGDVLVRLVSSMEKHAQIGLLQTQFAGMPAVSTFTRLWQFGLRHSVPVQNVGSNWWVSDCAFYWGHNAIIRTRAFHKHCMLPVLAGKPPLGGHILSHDVMEGIFMRRAGYEVRMIPLETESYETNPPTLLDFLRREHRWCQGTMQYWFLLKEPGLKSVSRFQVCQILASYLGPAFGLLWSLAGIANGMLGGYAATQFEYRFVAHLIMIGIWLLPKIACICASFDRYGSGFRYAVSLLLEIILMQLIWHVVSVAITVFFFGLVSGKSIRWDGQNRDRLGLGWRESFRVLWPQTLVGFGIAGLLALEDNVTWLWALPFVTGLCLATPFAVITASPRLSQIITRLRLFLAPEEAKLPPLLSVLVAPEIIYAFKAAATRRLGSKAILEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTA9</accession>
    <name>A0A7D5YTA9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g068890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540004.1">
        <property type="nucleotide sequence ID" value="XM_014684518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTA9"/>
    <dbReference type="GeneID" id="26247224"/>
    <dbReference type="KEGG" id="mbrn:26247224"/>
    <dbReference type="OrthoDB" id="4725912at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="161" mass="18168" checksum="7B6E7CBE64D0A5A2" modified="2021-02-10" version="1">MSSRYDKVEVLDYTKSTVLYNAQIQKSKPQISIFRPSDGMLCEELVALVTFHKLSSDIGIQMRDGRQLNMKRKHILSKISRVENATFEWSWKGNNLISGNLRLIDDESNTVAKLIEASSWSRRGLGYIAISGHFSSSIIDEIVVTGLAKLGYRLLGDKMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTE3</accession>
    <name>A0A7D5YTE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g034830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986598.1">
        <property type="nucleotide sequence ID" value="XM_066130159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239441"/>
    <dbReference type="KEGG" id="mbrn:26239441"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="13">
        <location>
            <begin position="3679"/>
            <end position="4015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="730"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1190"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1592"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1954"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2037"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2243"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2312"/>
            <end position="2515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2531"/>
            <end position="2561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2664"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2815"/>
            <end position="2921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2988"/>
            <end position="3018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3062"/>
            <end position="3095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3310"/>
            <end position="3385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1592"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1968"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1982"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2044"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2248"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2340"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2365"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2418"/>
            <end position="2430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2431"/>
            <end position="2506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2544"/>
            <end position="2561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2815"/>
            <end position="2867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2891"/>
            <end position="2909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2988"/>
            <end position="3005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3310"/>
            <end position="3320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="3329"/>
            <end position="3357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3363"/>
            <end position="3374"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="4015" mass="448366" checksum="061473C5390AB904" modified="2021-02-10" version="1">MGKIIKTMQSKHKETLSPWLKNYVETASAIDLPSLPNHLSTFPSRWPFGRGDLYHWIPLLNRFDSILEHFNKTYALNEGPQSRDFAADVLLNRAKDSAFSSEKQWTYEELQELGFSADGDRVLIEAVLLFTRMLLEHCGNRSIYASSPHLNDLLNTTALSVLISTLEVGSELAQRYQASVKRIGNASRQISAALLANHYNIDIERVQQIALPFVKTPIVSLADPASSITPVSTKGKEKAHGSSSRNSTPTHANDLVAIATCDDAMWQGWGDVKVLYYPQDSNVGVDVSNDAGRTSLPSTPTPLRRSHTVGSQQNTPRARNIGTDDSSPIIPRTPAVSEEHAIPGQKSFDLPKSVVSTTSIYDLVKRCPDDMPSSAKYELFHRVRVAKALTESLESRQKILAIRLLAITNLAYIHTESNFVDKVLRHDIDETRRYQLVYQLAELIHPSADGHSKIPLWLQTFALALLEAVSGFHARCQDVLSALNANVNHGILLYVIRKAVAGMQVDEATDIGDQASEADDWRNNLFSLTLHLSMATRVGSEMVSAGLMDILVEILHIRSQVAQRHHSMVLAFLDGLIWTYQNAFTAFFNASGLGAVAQLLVDAVTEAQNSLKSSKGVKPDQQSVVVDYEIPYYQQQTLKWLLKFVHHIMSNSYSYGGNTERLLRNLAENSDLLHSLREIMANKQSFGSVVWTNSVTILSDFINNDPTSFAAISESGMIKTYLEAITGQPVPEQQQGGESKQAEQHQEDQGDAESPDSSAAAASIADEDDRPHPPSDDDIRRTRRNKPAEGILASSEAINIVPQVLNSICLNNMGMKLVVASRAFDSYLEIFESSQHVSCMEADSDLAGNVGANFDELARHHPPLRTSISNAVIDMVARVRWLGIERGMESDWGARLYVTTAEGTVVTVHPNEHFMKAPTVESAPERQGATTEGADVDMSDAASTNETITEKNKKPQKLAPAQSLTPYIHGLANFLTGYLSNTLLKVNFVRKGGIELLLDLCESPSLDASFGDSSASRVLNQVIAQLVEHSPVRGLPSLLRRAQSNIDVLKPLAAKTEALPPYFGAFLATDLHVWSDDPEQSKVVLQATQKIKALLNAQNLIKIISDCFTTSRSNALQFYPVNIYDYYLKLVKSIGPLLRGILAEEAGELSVVPQHWSLRRQGFLGVTNTSEGRDAAGSDETSIPDVLNDAARSWPSADGTDTSAPVEPTEQERSSARFMNYEILHTLLHPMIPTSFPLFQSLGKALLPRREPNHLDPFPRPRQLEIAMALADTVLSHLGPSVAQAEPTSKDFHYWIIMLHTIHEMLIDHPSPRQSDRSNVQIIMPVLLAFKEQGGLDVLNSILRILASSVKAGPDSNIDETSKVKVAAFGLKKVLDLYYILVNGKYLSESSNHFNLHRQADRSQNIPNVAQQIVVEFRAAILPAIMELWTSNFVEKVPDATVKRLLDILKIVCAAEHEPQAIPKDAKAPLMLFKYTDARFNWASVQSVVKEVIDTGFEEDLVHEAVYRANGNTAPVIEYCRAHTDGLAGPRNPIPPEDADISALQQESSAVQEDQSNTVTAPDSDQMILDALPDISADDMVEYVDRHIGNIQADNDNSSEATGVTSSNHRDDTTDKIPTMNFVVNFNVVKDELDNMRSKIRAQLIDQCLDVIRTHPETAIEVSDLVSTTILRRQNQEAQEEVASTLTFALSSLSLDEDEKRRNGKCIAAYAHLLALLLQDENFFEHNKENLADKVDEYVGFLKVPLSSSTDELPPWIPYILLVLEALLCHDERPVPVQWKPPKSLEDPVSEPVIRLGLPLVGDENCNKILESLLNLLPRIGKEEILATAVLRVLLILTRKRRLAKVVGEKKNLQRLFLMAKQLSGSGSERLKQTRLTAHIITILRHIIEDEDIIKQIMRAEIQADFPNLIRNQRGHPDVSSFLRAMAPVALRAPDLFVEVTNEVLRFQRWMAPSGDSNRSQALVWKDQQSDSKTEEEKPTADGSSSDTVKPSTELADKEMADVPKAHHDIKRPVVENPDGVIHFLLCELVNYREVDDKEPSAPSDLNTEVTGTANLRDPSPKDISAADGKDKKQSKPLFKAEEHPIFVYRCFLLNCLAELLQSYTRTKVEFINFKRSAPPLSTTTPIKPRTSILNYLIYDLLCQGNLNGTTDTIVSKKKAATSSLTQKVLVALVSKTSEKAADRRADKFVYDDEPDLLFVRKFVLDTILKAYEKAPLTDEPLETRYSRMQCLAELMNHMIGERDRDQNPNSRGSDSLQSRSQAQLRRLMYEKGYVDKLTSSIAEISLSYPGVKRAIKYILRVLRVLTSTAKELSQSSILPADPAGDHSDEEFASSSSLSDVDDDDREETPDLYRNSALGMLEPRGEDDESDEGDEDDDEDMYGDEYDDDEMDYGENDITDGEDDISDDDEELGGMGEIEGLPGEPGVVEVIMDEDEDDEEDSDDEEDDDMDSADMEDVEDRVEIVDEDGNPLEEDGDSGWESESDVEEDDDPDQDALDYDAEVQEEGEAHMHGMAPGDLLDNMARAIMGDDGGYDPDLGLDDHYLDDEHEDGEDEDEDEDIDDEEYIYDEDYPDDQLPPMPSLGWDAVNPDMDDRHRNMLLVDGHRRPVLARMDNRSSFPGRFLGGSHRDQLGEFRSYFTSRNHRSTGAQSNAEDGLNPLLRRSDQANEGLPRPGQTHALDLRIPPGLLGAGRHSMDGPMGLLGELMEFLPMMSQSGNGQQAFHFHITGPGAPREFRDLGPARWVRTDNRRDATAQEPHQAVSFTAESTLDRYQEEARMVFGVNHTTEAFKLINIITAQLTPAAMELEKKIKAEEAEHQRRADEERKKREEEERLTQEAKAAEEKAAREKEAKEREEQERLARERLATAETTENEQPDRSSEEAMEGIETSGPSSEPQSAVEPGSTSAAAEQPRVMTTIRGEEVDVTELGIDPEYLAALPEEFREEVIAQTVSERRSQAREEAAAGESTDVFQEFLDALPDELRQEIAQQERQEERRRNREEARRQATVPSGQPPPAEMDAASILLTFPPALRQQVLMDQGEDIMDQLTPEMAAQARALSQHHPPMPQHQGVRSIVTPGQGPPQAAARDNSEGKAQRRAVVQILDKSGVATLLRLMFIAQQGSIRNYLFSVFADVCENRQNRLEVVSTILQILQEGSTDMNAVERSFGQLSIKARKHKERETDQKTPQSLKKTLTNLGTTATQVQQTNSETSPLLIVQQCLDLLVDLCTRSQHIPWLFLTEHEVVGSTLKRALSRKGKIKDSKAHKYAINSLLTLLDREIVIESSVVMTHLADLLNRVTLPLLSLDRKRKDTTEEVRKEAPVATEGEQRSASAEQQPPETGTSTEPPAGQIPTSEQNADAAEGEPHQQKKEPGSKKPRQLQPPVIPPQNLTLVVKIFVARECSSKTFQNTISTIKNLSAIPGAKAVFGQELVKQARLLSENIVSDLDDLLPHIEQATSGTEIQGVALAKFSPGASEQNKLLRVLTALDHLFDGRKKGGDGETEESKEHDKQHLVTSLYHNSTFSAMWEKLSACLKAIRERENMLNVATILLPLIESLMVVCKNTTASDDLSQSQASKGMVLSSPPPEARTASLFFAFTEDHRRILNELVRNNPKLMSGTFALLVKNPKVLEFDNKRNYFNRSVHSRSSQNSRPSYPPLQLSVRRDHVFHDSFRSLYFKSGDEMKFGKLNIRFHGEEGVDAGGVTREWFQVLARQMFDPNYALFTPVSSDRTTFHPNKLSGINPEHLMFFKFIGRIIGKALYEGRLLDCFFSRAVYKRILGKSVSVKDMESFDPDYYKSLCWMLDNDITDIITETFSVEDDEFGVTNVFDLVPNGRDVAVTEDNKHEYVRLVVEHKLLSSVKEQMEKFLQGFHDIIPAELISIFNEQELELLISGLPDIDIDDWKSNSEYQNYTPSSQQIQWFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELEGMNGISRFNIHRDYGDKDRLPSSHTCFNQLDLPEYESYDMLRAQLHKAITQGSEYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTV7</accession>
    <name>A0A7D5YTV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g001320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542940.2">
        <property type="nucleotide sequence ID" value="XM_014687454.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTV7"/>
    <dbReference type="GeneID" id="26244313"/>
    <dbReference type="KEGG" id="mbrn:26244313"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028888360" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="19854" checksum="5E18F07AE4698393" modified="2021-02-10" version="1">MRASLTLLLSAVTATGVLGAEAPIPGYGVEVLQWDIEVAVGRTEVLNGTVQEVYAQALQINPKFTLTIAAEARDVHQKQKRSSVQCGNWPLADKGRIQQGINYLRGAPAAPRNGPGPGNCGRVSCSYNSAIWWCNDNTTPKTLDSWNWVADSAQHIVNTCAPAAGSVSGQNFESGNWNTIVRGDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU26</accession>
    <name>A0A7D5YU26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-related C3 botulinum toxin substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RAC1</name>
        <name evidence="11" type="ORF">G6M90_00g089830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541643.2">
        <property type="nucleotide sequence ID" value="XM_014686157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU26"/>
    <dbReference type="GeneID" id="26245506"/>
    <dbReference type="KEGG" id="mbrn:26245506"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="218" mass="24514" checksum="FBF11A784F602050" modified="2021-02-10" version="1">MAQPNVQSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYTTSLMVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLLCFSLINPASFDNVRSKWYPEIDHHAPNIPIILVGTKLDLKEEYDRREDAEKNGDRHAFENASKEVKELKEKKRQRPIEFRDGLACAREIGAYKYLVCSALTQSNLKGVFDEAIRAVLNPRPPPKAKKSKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU78</accession>
    <name>A0A7D5YU78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">YTH1</name>
        <name evidence="15" type="ORF">G6M90_00g058200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544396.1">
        <property type="nucleotide sequence ID" value="XM_014688910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU78"/>
    <dbReference type="GeneID" id="26242808"/>
    <dbReference type="KEGG" id="mbrn:26242808"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="181"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI69662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="269" mass="30171" checksum="06E17CD790D746F9" modified="2021-02-10" version="1">MATATAPATAASSILNHASQTYNFRFSPFLRATYQVGLPLDRPICKAYQSGSCPNGTRCTERHVQDAKTAQATGGLNSLVCKHWLRGLCKKGEHCEFLHEYNLRKMPECNFFMRNGYCSNGEECLYLHVDPSSRLPPCPHYDMGFCPLGPLCSKKHVRRKLCVFYLAGFCPEGPECKAAHPKWSKDLDKPTVKADGKEEEEDGHVDSGMRGDDDGSERVTRDGMGRGDRDRDRDRDRDRDRDDGRHGGRFRGGGKWRGGRGGRFRGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVV3</accession>
    <name>A0A7D5YVV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g001480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985602.1">
        <property type="nucleotide sequence ID" value="XM_066129509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVV3"/>
    <dbReference type="GeneID" id="90967396"/>
    <dbReference type="KEGG" id="mbrn:90967396"/>
    <dbReference type="OrthoDB" id="4939943at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="139" mass="16077" checksum="6DDFF1274E1760B7" modified="2021-02-10" version="1">MCGIQKSTERCTKCGTDISNVEERHWCQEALENGEFGKCKKRVDTTKVTFKSHESCEGTNIEAEAGFPMGSVFDDFNPLEEFSANMARHTEAFCRNNRGGRAGMEAWRELNRNATREREALREMARERSRRWRCQGWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW12</accession>
    <name>A0A7D5YW12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chitin synthase regulatory factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">chr4</name>
        <name evidence="4" type="ORF">G6M90_00g042100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547549.2">
        <property type="nucleotide sequence ID" value="XM_014692063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW12"/>
    <dbReference type="GeneID" id="26240112"/>
    <dbReference type="KEGG" id="mbrn:26240112"/>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="795"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="914" mass="99760" checksum="897E239749A1F4DD" modified="2021-02-10" version="1">MAPQFGATFVPGGFDDYYLPEVVAPSPQRVTPQVPQNMQDDLQRLELEATDSEKRETREAPSQYSRQPSLSTITPRHSYPQTDQSGVPNTVTTQVDSDITAYKDTEGRAQRLDTMGRDAPSFSPFPKVAGDNIPPADDSKEEILWNARKHVLHSQDVRMQISWAGDVLIWAEIAMDAVARESAEKPRPATPRIEHELRLDALNIVNYLAGQEHPQALYMRSKWLEFGKFGHRVDKREAYSGYKRAAELGNARSEYRMGMLYEQSNDMSKAKEHYYKGMSLKDSAALYRMGMMSLLGQHGETKDYAVGLERIRAAADGSDEDAPQGSYVYGMLVGRDLPDINVPDGLLPYNLETAKMYVEKAAYLGFAKAQLKMGQAYELCQLGCEFNPSYSLHYYGLAAKQGLPEAALGVSRWFLFGYEGVFKKNEELAFKYAQEAAAARLPTGEFAMGYYYEIGIHVNQSIPDARKWYQLAADHGNKDAIGRLESLSHDKSLSKQDHETTTLTRIKSQHGSQRGKRPDRFKQPQHMPTLSETTPLSPTDNKPHLSQPAYTKSHSATASPRLSPQPSPGIKPTIVSEQANLPDPSRASLVGTDRPQAFNIRLEGNAPQPMRSHSAAPYPDDDRPAPLNVNRPHSTAPYPEDDVPAPSRRRYGHGLQPAHGPQADRPSSAFGIKPQSAGPRPIPISHSTGSLQPPAPAGPPQSRVASAGWEPQGHPGAYRQSSPGPGLSGQRPQPGDPMYGRSDSGQPPISGKMAGGKLQKQPGQQPYSSVSPTSADFGRDYGPRTSSRPASEMPPQHDLRNNSHGYERFSRVPGATGRPERLSSLPPQDTHQPPRVSTGFGQTTSSQHRPGPVSGKPASAPPNATGKRPSEANHPSGPATQSAASAPAKPAKGPATFEDMGIPQGKQDGDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWF2</accession>
    <name>A0A7D5YWF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FEN1</name>
        <name evidence="19" type="ORF">G6M90_00g047470</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544865.1">
        <property type="nucleotide sequence ID" value="XM_014689379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWF2"/>
    <dbReference type="GeneID" id="26242206"/>
    <dbReference type="KEGG" id="mbrn:26242206"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="345"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI67784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="44786" checksum="E00506DBEB7B465E" modified="2021-02-10" version="1">MGIKQLFQIIKEEAPEAIKEGEIKNHFGRKVAIDASMSIYSFLIAVRSDGQQLMNDSGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKQEATEGLEEAKETGTAEDVEKFSRRTVRVTREHNAECQRLLKLMGIPFIIAPTEAEAQCAVLARAGKVYAAASEDMDTLCFNTPILLRHLTFSEQRKEPIQEIHLDKVLEGLNMERSQFVDLCILLGCDYLDPVPKVGPTTALKLIREHGTLENVVDAIEKDSKKKYTLPEDWPYKDARDLFFEPDVRKADDPLCDFKWDKPDVEGLVTFLVTEKGFSEDRVRGAAARLEKNLKTSQQARLEGFFKPIPKTDAEKAAHKRKLDEKNEEKKKKLKQDKKDKAAQKAKPRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWI1</accession>
    <name>A0A7D5YWI1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="26239310"/>
    <dbReference type="KEGG" id="mbrn:26239310"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028935719" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="173" mass="18802" checksum="FBFD00BEAC0579B6" modified="2021-02-10" version="1">MKFSAALVVAAMGAAPAAALPADISSDLPPRMFSNLSGLQSKYARGIMAQAKKEHLGSQGCRAGIATALVESTLIMHANTAVPASLAYDFDRLGQDADSIGLFQQRASIYTNIKCSMDVACSAHQFFKEMKNVPQWKYMDVGNLCQEVQRSENPERYHEFMDQATEICQAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWK2</accession>
    <name>A0A7D5YWK2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g030860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684167.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247564"/>
    <dbReference type="KEGG" id="mbrn:26247564"/>
    <dbReference type="OrthoDB" id="4216719at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="583" mass="65414" checksum="D8499500A3525CE7" modified="2021-02-10" version="1">METVGVINTRKMRYTGPGLRCLKSGGLHPRRDALCADDDDVCYREPFYGRPWSQSKIRLVPCPPAAHPKRRIGHYPLTSQLAGWVLDAFSNYRPSRECMDLVRPFGAELHEVLDTERAAGSGLHDLDLVELTYQVTLEVGGQILLAATRNGNTGDMQPEFHSSQAAHDEHFAPWGRLLTGLVCDPPIISQFPFYLMMCQSFGLETDSRQENYVYSALTGVDWARGKNVYSERFRAFEERARASVPNLDDRLSGQDRSFWRVSLAYLAAMNRLENSRAFTTPRVSHIETGLDPRLLMAARGFDTIGSAYMCSDGAAYLDNAGMDALVGSAVPNDVMDLHTDIYTGETRNLLRLLYPSGQGLDAAMATMATVLSGMLCELFRGHKLARFGGREDGRIAATSPPYSFCRARHRRIFEVLEAYISRYPDFWRWTWAILRRAKSQITEAGLDELLVEALGRAVRRAPLPDAPYNAFFDSYFDMVEGSQEPGRLSRTLGVQDELADIVRRIHDLWHGRLLDPDKKPGWGRRFDDESDALFRQAGEFLGGKGGITAEVYKFAIAYGRLSMSLPYIAYHTVDAIILSYGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWT6</accession>
    <name>A0A7D5YWT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mug71</name>
        <name evidence="7" type="ORF">G6M90_00g012570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549266.1">
        <property type="nucleotide sequence ID" value="XM_014693780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWT6"/>
    <dbReference type="GeneID" id="26238710"/>
    <dbReference type="KEGG" id="mbrn:26238710"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06156">
        <property type="entry name" value="eu_AANH_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="159"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="823" mass="88684" checksum="C5187D22FF1C86A0" modified="2021-02-10" version="1">MSGEKLNVIALISGGKDSFYSLLHCIHHGHRIVALANLFPISADGGGDDSTAVRVIEPGRHDVDSASATTIDGHDAAALPDSERDLNSFMYQTVGHEIIPLYASATGLPLYRQPIVGSALRHERDYDYTSAHGQGSAAAADETESMLPLLRAVLARHPEADALCSGAILSTYQRTRVESVALRLGLTPLSYLWKYPILPSVPGALADEAQLLSDMAAAGVEARIIKVASAGLDERHLWEAVTSETGVRRVKSSLRKFGAAEGASLGEGGEFETIVVDGPDILFKKRIAVPDGGRKVIAEGGGSTWLMLRGAKLEDKAVHGQETPSSVREPALLEASFQSVVDALDLTTPVQHAAGFRSSKLLPKSDVQFRADSDTLHWHVVADASATGPFIQNEAIHVVDKIKSLLSTNGLDSSQITSVLILLRNMADFSIINSEYGKLFTKPNPPSRITISSGDLLPQDRNIVMYITAPVANAKVARNGLHVQSRSYWAPANIGPYSQAIEAAVSVDGEPTRLRSVTVAGQIPLIPASMALPTASKTLLRHQIVLSLQHLWRIGAEMKVQCWSSAVAYFARQHGENVAQESAVLAGQAWKLAHGSPDCNDDDDDNGPDPWDLKYNQRFQVLGATETKTSCPSIPDWSAYTLRQQNEPDSSVPPLFTAEVESLPRGSLVEWHVHNGLKQIEAGSVELIHLPTAGTVGGDGWQSWHLIVKAGENHIVYTTMAYSGASQDGPVVEFRVLERELGAMYRASIHTLQPNVMSLAANPLPYLGYVDLRRTESVWGHNGSDDVEIPFAVVPCHSLWDSAGQRLTAVALYKSILTDACAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX64</accession>
    <name>A0A7D5YX64_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g018320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548707.1">
        <property type="nucleotide sequence ID" value="XM_014693221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX64"/>
    <dbReference type="GeneID" id="26238151"/>
    <dbReference type="KEGG" id="mbrn:26238151"/>
    <dbReference type="OrthoDB" id="5091726at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="195" mass="21774" checksum="97C7019CEE4B59B3" modified="2021-02-10" version="1">MSPVAHSIEQSRLEIVLLAAGVLVLVLFFGIFILVCVSLTHSNAPLSRHRATSWGGYWNERWDAGPSAPGQDEGVFHSVRRRSVSIAEEVRKKLTSLKQLLTLDMPDYDDVPRQRYIESTDFTPYNITTLNDGTDHGLSTLLLDDNSNWHDLLESPASSTGRDREGGIVTKRPERAMVHDDSCDLEAQDSDDSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXK6</accession>
    <name>A0A7D5YXK6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lon protease homolog 2, peroxisomal</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LONP2</name>
        <name evidence="16" type="ORF">G6M90_00g023060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 12">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548249.1">
        <property type="nucleotide sequence ID" value="XM_014692763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXK6"/>
    <dbReference type="GeneID" id="26237693"/>
    <dbReference type="KEGG" id="mbrn:26237693"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000002">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000039">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03121">
        <property type="entry name" value="lonp2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027501">
        <property type="entry name" value="Lonp2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="15">
        <location>
            <begin position="9"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="14">
        <location>
            <begin position="722"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="8">
        <location>
            <begin position="923"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 10 12">
        <location>
            <position position="858"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="479"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI63547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="925" mass="101143" checksum="61AEBF7739B7C89D" modified="2021-02-10" version="1">MGRSQTASLPIIPLARGTVLLPGLIQRISVTSSRPDIPALLAHVYEQAAAKGPEGRIDSIPIACVPLSSPFVGPTGQLLINNGEEIDTSQLAEVNPGSANKADVFGFGVAAKIVGIDGRGAGEFALRVEGTSRVRVDNISRERPFFQGRVTYFSDEIDMADKQLQDLFGLLKAQSRELVTILRISSLLPRTKNGPALSPGLTKRLEMLIMRREIKEAGLLADFMSNLVEASHEEKLGVLAALDVKVRITKVIELLERQVGGIKNNFKITTFTSVPVQILDRLNDNPNKRNSSGLPIPGVNFLSGAGQMPSGNDQGDEQEANELDELKKKLQNAQLPAEVAKTVDRELRRLQKMMPMNQEYQVTRNWLETLSEIPWAAVTDDRLGPETLNRARKQLDDDHYGLDKVKKRLIEYLAVLRLKQSLNDDVEEQIRKAEAEIAPEHDSGNPPTESAANPENSAKLQILKSKRMVDKSPIMLLVGPPGVGKTSLAKSVATALGRKFHRISLGGVRDEAEIRGHRRTYVAAMPGLIVQGLRKVGVANPVFLLDEIDKIGMASVHGDPSAAMLEVLDPEQNHTFQDHYIGMPIDLSKILFIATANNLDTIPAPLLDRMEMIYLPGYTTLEKRHIAMQHLVPKQIRANGLVEDQVTFNKDVVSKIIESYTRESGVRNLEREIGSVCRAKAVEYAEARDGGSIEKYKPLLTIEDIENILGIEKFEEEIAEKISRPGIVTGLVAYSTGGNGSILFIEVADMPGNGRVQLTGKLGDVLKESVEVALTWVKAHAYELGLTPEPTTDIMKERSIHVHCPSGAIPKDGPSSGIGQAIALISLFSGKPVPPTMAMTGEISLRGRVTAVGGIKEKLIGALRAGVKTVLLPAQNRKDVKDLPQEVKDGLQIVHVSHIWEAIRLVWPDSHWAADSHYAGIESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXW2</accession>
    <name>A0A7D5YXW2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g023230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548232.1">
        <property type="nucleotide sequence ID" value="XM_014692746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXW2"/>
    <dbReference type="GeneID" id="26237676"/>
    <dbReference type="KEGG" id="mbrn:26237676"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="467" mass="51383" checksum="B9BF281CC7CFA602" modified="2021-02-10" version="1">MSVEVINTISPNTNETILSRNGVSAAELDLMPEVATEAFQSFRKTTLKERQEIVKKFLKELSSHEAELAEELTVQMGRPIAFTGKEITTAIKRAEYLLKISDEALKDTEGEPERGFTRFIRKLPVGPVLIIFAWNYPYLILMNSIIPAILAGNTVILKPSPQTPTIVEHVAQFFAAAGLPEGVLQYFHCGSPSAMESLIRDPRIAHVCFTGSVAGGLAVQKAASDRIVNVGLELGGKDPAYIRDDVDVAWAAEEIVDGAVFNSGQSCCSLERVYVDEKIHDAFIESVQKVLRGYKLGDPFDKTTHVGPVISRRSKQAIESHIKDALDKGAKDATPDNESFNNPPPKGNFVKPTLLTGVDHTMTVMTEETFGPVIPVMKVKSDSEAIKLMNDSEFGLTASIWTKDTEKGYELAEDVEAGTVFVNRCDYPSPDLAWTGFKNSGKGQTLGRFGFEQFVKSKSFHMKKYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY21</accession>
    <name>A0A7D5YY21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g099460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546401.1">
        <property type="nucleotide sequence ID" value="XM_014690915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY21"/>
    <dbReference type="GeneID" id="26240824"/>
    <dbReference type="KEGG" id="mbrn:26240824"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="250"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="445"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="740" mass="86103" checksum="32B94F4E9A0BA8B3" modified="2021-02-10" version="1">MDITQRPMPGSFIDEDLAELYHNPFETIQILQDEWRDKDHACPWSTDNMSDIDLGDIDWHKYEPPGVLRKAPNFTSLILQDIINTSIDNVKARVVREDHQKQLEDERHQAAQEEARKNGNPPKPYLPIIIPPEKPIEPDASPTTILNGANLALACFNTVSVKSAGKATEVTVVKDAGRRRFAIRRLFHRTPETGESSAMGGAREALRQKLEARLSKVDLSNTDSKTQEALMALRKSGFIQNAELPQPPEPEVECVSCLDDIPVKDAVRVQCHSYCKDCFVRLVTAATQNEQQWPPKCCLNQIPFRLVLKHIPDDLKKTFQVRASEWELPMSERVYCSQPECGIWIRPKNIRLNKRQGKCERGHLTCTICRGPSHGNEDCPQDYDMNLTNILAEEEGWKRCFNCHALVEHGEACQHMTCRCGTEFCYVCGLRWRTCHCTMQQLHTLKEAADARREQRRVREQAEAEELRAILAQIEEFEREEAARAELERLEQARLEEERWQQQIKERLRLESFRRKEVESKFRQLRLRLNELHELQQAMLESYQEDCAAMLLHEADAMKLNLAARHEMERIELAQKISQKMSTRENSFKSEYAARLAHERKLEQTYLEQLQDFWSGKVNAEAEIEQSMIPLRRKMDKGHGAWQRWRDQQIGVYKAKLEDERIMKEEVMYSQSERLRDMYDERETQLTRKMVAEKKWFREVVCERETLLGGWEVSEMEGDADSLFASEGEPQKDPEPENLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY80</accession>
    <name>A0A7D5YY80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g086360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542478.1">
        <property type="nucleotide sequence ID" value="XM_014686992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY80"/>
    <dbReference type="GeneID" id="26244992"/>
    <dbReference type="KEGG" id="mbrn:26244992"/>
    <dbReference type="OrthoDB" id="4940174at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028972818" description="Cell wall protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="17230" checksum="9ADD4A4BB86D3E80" modified="2021-02-10" version="1">MKFIYASLLCAVVSAAPVAEVKRQTTGGATAEGLSKALQATTDSFRKLTDGLGGLSALGGGLGASKRDETPAGDVTVRLDQPAVDLSIGEGSGLVGKRQQGLGSLSVLAQTASHAVLNGLAGGVLKRDGKQDPSKRQLDTSLPNKVLNDVTSGKVMEDLPKVPNVHIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYA4</accession>
    <name>A0A7D5YYA4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">met-7_1</name>
        <name evidence="4" type="ORF">G6M90_00g047750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544892.1">
        <property type="nucleotide sequence ID" value="XM_014689406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYA4"/>
    <dbReference type="GeneID" id="26242233"/>
    <dbReference type="KEGG" id="mbrn:26242233"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="577" mass="63389" checksum="088CB2A27001074A" modified="2021-02-10" version="1">MTQEPKTAELGQGLPPTDIHAVSVSLPKWRDATGWATKDPQVLAHLKTGYPRFYIHPFIERLATLLLQLLMKSKSVASSVGEIYGEESTAAAAAMLFPHASLGTSCRDYLQRAESNPSNKLAIFAFQVDFAGEVQNIHLRVAKSTSGAFQSLCIVVFPHDLSKEAKMFWQHTGFGVTSRHALYWLERAPCLGEVVASIRQDGKLPLDDAKQAATKIKNRISELLSSERSTVETQDVFLYPSGMSAIAHSASALQELYKGSSDSIRVAVFGFLYVDTFKVLSKVKQIECVLYGHASPADMDQLEHDLQDGMEIHALYTEFPGNPLLGSLNLERLYKLSQRFNFHVIVDDTVGTAVNLDLAAFCDVLCTSLTKMFSGACNVMGGSLTICPNSKSKRALHSTLTSQYSDTYFPLDLLVMAQNSKDFAERVHIANGNAEAIAAKLRDHPVVDRVFYPRGSATQHLYDGYRRRRPRAREDEDGQDQAQAGYGYLLSIRFVQDSAAMAFHDALDVAKGPSLGTNFTLCCPYTVLAHASELAWASEFGVVEHLVRLSVGIERRGELEGAVDRALEVAAKAAQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYM6</accession>
    <name>A0A7D5YYM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein SAT10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SAT10_1</name>
        <name evidence="7" type="ORF">G6M90_00g104390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987760.1">
        <property type="nucleotide sequence ID" value="XM_066131643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYM6"/>
    <dbReference type="GeneID" id="90968195"/>
    <dbReference type="KEGG" id="mbrn:90968195"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="394" mass="43782" checksum="36DDC1621B2F30F8" modified="2021-02-10" version="1">MDPNQKLGEYGSMLHYAALWGWLELAKLLCESDKTDVNLVGQTHGTPLQVAVIGGGKDGPKMVELLLSRGVAVAAAVAEYITMANMILDHDNTTLNMHAGHHTTPLQFAIHARWKSMVEFLLERHSMFKDNDGTPLHLAAHLGDRKVVRCLVRSKYVSPGARDMCGRLPLHLAACSRCLGAGVHNLRMLTNDEFTLVSTDEHQRQHALHFAAGCGHLDVVKLVLQKHPDAVRDCDVDGWTPLHWACRSHSSKVVEFLLDRDDSTCRNARSLRGWTPFDVARYHGGRLTSDGSLRNRLRPNGPRPPFQSPADLAADEETARPLKPEEAASSSSGLGVICDACKCVIYGPAYECTRCIDFHMCFKCFRRVVKMHYRGHSFRKITCSGEILETDPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z032</accession>
    <name>A0A7D5Z032_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ-loop repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g021240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985884.1">
        <property type="nucleotide sequence ID" value="XM_066129869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z032"/>
    <dbReference type="GeneID" id="26237868"/>
    <dbReference type="KEGG" id="mbrn:26237868"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39701" checksum="2BBC508D2A03ABAE" modified="2021-02-10" version="1">MESLLSYRNSECEALKDPSYLELVISILILVGLLISYLPQHYRIISRGTAEGISPYFVLLGTTSATSGFANILTVPQSRAAIGCCKELEAFQCTAGLLGVAQLGTQWVCFTLILVLFLIFFRYRDATIPSEELAGESPKWQTAVGVGLACVVHGLLVVIITGIFTIALPNHLTAWANFLGVMATVLAAIQYFPQIWTTYHLKHVGSLSIPMMCIQTPGGLLFAASLYARLGPKGWSTWAIYLLTAIMQGCVLVLGIYYEMAARHHERQQSNQNADGTYSSLQNSAPPRPSLASRTYSEGWERGLPGPFTGHPERYAETEEDLDDIQEREQRAIERENQPLLRPGGIGNPRKNYRTTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0D3</accession>
    <name>A0A7D5Z0D3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g042670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547603.1">
        <property type="nucleotide sequence ID" value="XM_014692117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0D3"/>
    <dbReference type="GeneID" id="26240166"/>
    <dbReference type="KEGG" id="mbrn:26240166"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="475" mass="53039" checksum="EC1E4C2F2655D2D9" modified="2021-02-10" version="1">MDELQEAIGFDGAHPVDLKRLYLTPENRLHVHYVASSSDEEQLTLTLVPTSTKILRTEQASISSEAMLLQWLGSGGHVCPLAKERQRNPEALEKAPKGSDAEAKLSKHTCQFKKTLPRVVKHGRVKCPNDVEFLLTTRTGGAILSSAINTLSKPQQRRIDFQIGQLIRELSTCQSPNGHFGVASAVLKAAGIHHTMLILSPVPTEQVTNDAVYARWSDAFLSLLESVLRDAEDVALSLEYDRLRFHAGRFRKILDEVTVPCLVILDAGEYANTHIITSSDSTTQDLKVSMQRHGNTSFGTEKPQTVAAPLFEANRSARNAQKGNEHGPVPVPVPITTRQSPDTPRVIGIQDWHNSVFGDPLFTSVLTRHKNTDMLDGLMDQTGHVESKAIRQAIHLAKDFQHVDVRRLLYDCYHSVTTIVTEYYRMTVDGDDRELPARRRLVQAIVRLDDLDDHGRKLHPHPCPAHPIAKRKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0E9</accession>
    <name>A0A7D5Z0E9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g071490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987021.1">
        <property type="nucleotide sequence ID" value="XM_066130955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0E9"/>
    <dbReference type="GeneID" id="90967935"/>
    <dbReference type="KEGG" id="mbrn:90967935"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="41" mass="4750" checksum="CD10F04AA907CAE5" modified="2021-02-10" version="1">MSLEDDGYQRPLYGHVGTDETHKEAKEVGEKDEKNKETQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Y3</accession>
    <name>A0A7D5Z0Y3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium permeable stress-gated cation channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g029600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541211.1">
        <property type="nucleotide sequence ID" value="XM_014685725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Y3"/>
    <dbReference type="GeneID" id="26245846"/>
    <dbReference type="KEGG" id="mbrn:26245846"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF53">
        <property type="entry name" value="DUF221 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="810"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="65"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="236"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="529"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1077" mass="120883" checksum="0A9310929BF5AE19" modified="2021-02-10" version="1">MALDSAPHPTDAAISHLWHFIETRGLDLDVGSSQDPRQGSARNDSSGGGTLSQTAGSKGSSLGKLGTTFIPVSVFTAVCLVIFILLRRFCKRVYAPRTIPELRSPDVPSPPLPGGWLNWIVPFFKTPDTIVLNHGSLDGFFFLRFLKVLRNICLAGCLITFPVLFPIHATGGSGLTQLEMLTIGNVKDPQKLLAHVFVAWAFFGFVLYMIVRECIYYVNLRQAYLSSPYYADRISSRTILLTCVPKEYLDERRLRKLYGDSVRRVFIPRTSKALVKMVKEREQTAERLEKAEIALIRIANLARQKQLAKDSKLAEPSTAAASITESTGSKQDLVVVPSDSTANDTCRGDLDEAESPGSIIRLESLRRNPDKDNDDTSQHEGIKLNSIMADENEKLDQDDGEYEHPYGLSMDLPDVRGSVAAQWIPVQRRPYHRPIGNFGRRVDTIRWTRTRLRDLNLQIFKMRRQVRRGDGITLPSVFIEFYTQEAAQAAHQVLTHHRPLQMSSRLLGIRPDEIIWSCLRMPWWELIIRRFGVLTLVTAAIIFWAVPSAFIGTISNIEGLTQKLTFLSFLNKLPSVILNFIQSFMPAVVLSLWMAAVPWMLRFCGAQSGIPTITRVELFVQNVYFAFQVVQVFLITTLTSAASSALGKILSNPLGAKDLLAENIPKASNFYLSYIMIQCLMSGGMRLIQVFGLIRHYIVSRVSAVPRTRYKRWCKLDSPYWGGVYPIYTNMGVIALSYSCIAPLVLLFAAGGLFATQVVWKYNLIYVLDSDMDTKGLFYPRALIHLTIGLYLAEICLIGLFALKGAFAPLALMVLFFIFTGLVHFSLSDAIAPLLLNLPQTLPLEGEIQEEEKAKALREKELATARLEGEDGATGAANDYYDSEQVFGDEEQLEQSDTEEEEEEEDSGDEHGPITGTRAVEGAASIGSTLKEWAKATTTAKVNKEINSPGVQEFLAKIQFWKHDKHANGEPPGFLARWLHPEEYEDFVALRNTIPGDQLRHVEYPSEFRKRCYLPPEMWAPKPTLWVPRDEARVSRQEVAHTKKYTPISDKGAELDEKGGVVVYFDKAPIKKERMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1F4</accession>
    <name>A0A7D5Z1F4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g047860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986569.1">
        <property type="nucleotide sequence ID" value="XM_066130436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1F4"/>
    <dbReference type="GeneID" id="26242243"/>
    <dbReference type="KEGG" id="mbrn:26242243"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="313"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="723" mass="79249" checksum="B5EEDCBCB1323E01" modified="2021-02-10" version="1">MSGSPPCRRCVEQQLECVLAKSRRGGRRIKGVRNSAVQPPPPPRRDSDLGPSSNPRGPASSTHDDDDDDESDYHSTQGSQARPAQPPAGTDAVQGWPSSPPHAGNWRADSPDAGSTQEMADSRTSSDGLEGHIATTDLLNPSDALDLLAQVADLDPGRQRNTLTGQPGQSNRHVDGMQQTVGRPATSYYPPLHDGILTPSDASYLVKKYHEKFHPFFPVAFADIFEEGPITEWAEKEPHLLTAILTVASKDDPSWFRVYDACSRHIESFMSTLIYAGSNSVGSVEALLILAEWAPQRPQENSAIGCGQEDHGAWMLVGLAIRLGYLQRLEQTALLPDDKKPSLEVSRKRVAWAACYMSDRQVSIRLGKGFWSRGPGPSLHLRAADFPTLHAQALGPDNMGLLFQAHLELTQLISNAHDILYSSTSHRKQLYVGGEYVRYIDDFAQMVRKWKLTWANHSFTPPVKASLVLSFEFLRLYINAFAFQANLNRAAARNAQVGPGKASGPLFSNIAGKPDARFIYESIDAANSLLSILNSFIDPVAGLKCMPLKYCLYVIYAAVFLFKARLAGAISSEGDRGVRRAIHGTITQLQKTSNNPQSLGRRYATSLRLLWRKSSAKPSTKGATRSDPVSEPPELSMSQLEGQENIVPSATSKSAMDMDPLSGFSWRDLDSLGQFIANNTTMNMTDGILAGTDFDWEHSSGGLDDLAMRPQFDTMWAGHDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1W1</accession>
    <name>A0A7D5Z1W1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter asaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asaE_6</name>
        <name evidence="5" type="ORF">G6M90_00g053880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541016.1">
        <property type="nucleotide sequence ID" value="XM_014685530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1W1"/>
    <dbReference type="GeneID" id="26246322"/>
    <dbReference type="KEGG" id="mbrn:26246322"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="252"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="447" mass="47065" checksum="9FFD0C8DBCF74C57" modified="2021-02-10" version="1">MSSTITTVQPIAVSEPTSHDDIRLARLEDHDEHDTTPMRLSDNDTNWDTKEGWVVVAAGSAIFFVFLGLIYSYGIVQLHLTESRLASISTLSFIGSVGAAMSPLTGMIVARIIKLAGYRVTALIGSLFLGLGEFTAGWSTKSVPAMFVTQGFLFGIGSALLFLPAATVPSLWFKRKRGLATGVVFGGAGIGSAVISVSMEKLIGVVGLESALKILGALAWAICITASYFLRAPAGRGRAVSSVQWRLFRSVKFNMMLVMGAIATFPLFVPPFLLPLYVANMGFSGQAAAAILACWNIASALGRIGMGFGADAYLGPVNSLLISLTVIGVSAMALWPFASSLGLLVFFAVLNGIGSGGFFSLMPVVVGAVFGDGQLANVMSMLTTSWTFGYFMGSPIAGYLLDAYGGAEAGLAAFRPTFFYAGSLTLASAGLILAVRLMMNRKIFARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2C5</accession>
    <name>A0A7D5Z2C5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl-24</name>
        <name evidence="6" type="ORF">G6M90_00g092100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541854.1">
        <property type="nucleotide sequence ID" value="XM_014686368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2C5"/>
    <dbReference type="GeneID" id="26245322"/>
    <dbReference type="KEGG" id="mbrn:26245322"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="160" mass="17927" checksum="29A25CB3EFACF508" modified="2021-02-10" version="1">MRTYDDTFSGQRIYPGKGKIYVRGDSKVFRFQNGKSESLFLQRKNPRRIAWTVLYRRQHRKGISEEVAKKRTRRTVKAQRAIVGASLDVIKERRSMRPEARTAARAQAIKESKEKKNAAAAAKKAEKAKTAAAAGKGQTQRNVSKQGAKGAPVKVAARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z322</accession>
    <name>A0A7D5Z322_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BFR2</name>
        <name evidence="6" type="ORF">G6M90_00g039790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547332.1">
        <property type="nucleotide sequence ID" value="XM_014691846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z322"/>
    <dbReference type="GeneID" id="26239895"/>
    <dbReference type="KEGG" id="mbrn:26239895"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="247"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="430"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="544" mass="61217" checksum="CBCC9666706AFF2D" modified="2021-02-10" version="1">MAKVKGRAEQFQDPDEAIIKDHDPEANGSSSEDSEDENLGTEHYVRVGKSKLRQKESVSLGPEYRGSRVSRSALDNETEDDEDAEESEDNDDDEDDYDDPDVADLEADEAESNDSEIDSDNALGESDAERFKDYSFRGSAKPAKPKGRGKRATAADFMSVDDENRESDRDEDMDDGLDALVNGGDDSEEVDDEDEEDSEEDDGDDDDDEEDEEDDEDGDDDETEEEETSGKKIAARPHLSALSNRADIDKGVAIQKQRKIYDGLLNLRIRLQKALVAANSFPTVEAGTDAESEPYEAAEEAAIKLLNTISSLRESIKAPTKTGEKRKRDFVASMSNDDIWEQLQDEDKDATGFRQERLEKWSKKVQSVNMARPSGISEKNKTLISALQEQLIVPNNRLVKRTRVPRSCAPAQLAKKVATDEYVYDDADFYQLLLKELVDQRTVEGVADYATAVPTVMVTATKEAKVRKQVDRKASKGRKMRFTVHEKLQNFMAPEDRRGWEQEAIDRFFGTLFGRKLELNEDESDHEEMEGVDIEEEGLKLFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3J8</accession>
    <name>A0A7D5Z3J8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NEDD8-specific protease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nep2</name>
        <name evidence="7" type="ORF">G6M90_00g019510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986038.1">
        <property type="nucleotide sequence ID" value="XM_066129836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3J8"/>
    <dbReference type="GeneID" id="26238034"/>
    <dbReference type="KEGG" id="mbrn:26238034"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="36"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="29829" checksum="C2060EBA1F3CF165" modified="2021-02-10" version="1">MIVPYYGLQAQSEYCTRHVTQKFLSPEKSYLSYYDVLLTVEDIKSLKNDWLTDNNIAFWEEYLERETLPRYPQARIVLLRPSMSFLLMKEPDIRHVRSALPDFSKVTHVFLPINDNRNVSVAEGGSHWSLLLVSLLDGIAFHYDSLGGANFAEANLATRRMGEVVGRQMRFINLEDSPQQENGSDCGVFVCLLMRHLLVKRLLSANAREKVSMSMAGKMVDSNGGRKEMLRIIENLRKEGERRRSRSASPFTNKTPPRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z412</accession>
    <name>A0A7D5Z412_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g080490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987109.1">
        <property type="nucleotide sequence ID" value="XM_066131159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z412"/>
    <dbReference type="GeneID" id="26247824"/>
    <dbReference type="KEGG" id="mbrn:26247824"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF114">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="355" mass="39358" checksum="276F09B46AAE0435" modified="2021-02-10" version="1">MAKEGIGQVISWYICTVVALLFLVARLSTRYQRLRSLAIDDGLITLAACCLIGDLVIQQYMWNLGMANIPKASREELIQIMKMIVPGSILYVTSLWAVKIAMVLFYKKLAAPGTRLQLIYNIVLALLVAFWSTIFLNIIFQCYPHDKRWSTDPNYKCDPRQGDINYWLTVLLNIITDVIIISLPISMVLKLQMKLKLKLGVIAIFALGFFVVIASIVRAYYSRRKETMLTCTVSMIETAVAIIASCLPPLRTLFIGPASSVGTKSTRGHYELSSGGHHRSWRTNRGRNTTDVMGGTRSKDNSSEDNLVNDLGAPVASASASASGKTGEIKVNTTFQVHYGRDEEGGVHPTKQGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4D5</accession>
    <name>A0A7D5Z4D5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent monooxygenase DEP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DEP4_2</name>
        <name evidence="5" type="ORF">G6M90_00g104050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541401.1">
        <property type="nucleotide sequence ID" value="XM_014685915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4D5"/>
    <dbReference type="GeneID" id="26245651"/>
    <dbReference type="KEGG" id="mbrn:26245651"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="571" mass="63508" checksum="F9ED30828D7605F8" modified="2021-02-10" version="1">MSARQEYDVIVIGAGWYGLAAARTYIELHPHEKIAILEADSTCGGTWSRDRLYPGLKSNNLYGSYEYPDFPMTQDVYGVKPGQHIPAGVLHKYLTDFATKFGVLERTRFNTRVDALEATAQNSWIVHTSPSKNADPGRLPEILHAKRVIVASGLTSQPNIPHYPGQDTLESTFFHAKDFCEQRDTVKTAKRAVVIGGGKSALDCAYAFATDGGNAQVDLVIRPTGQGPVWLCPAHVTPFKRATEELLNTRLLTWFSPCPWGGEDGYSLARRFLHGTAVGRFLTRSFWRLLSADVIRANGYNGHPELGKLKPWESVFWTGSGVGIHNYPSNFFHLVKQGKIRVHVASVSRVGGKKVYLSDGDVLPDVDVVVCATGWDKKSGIEFVNFHPQASLADMPEEKKGALVSQADDCILSSFPLLREQPALRGAPKSVEPLRNYRFIVPLDHVSSCNIAYAGMVSTVSTTMFASVQALWISAFFDGKLRRGPGGQADVMQEVLLHTEFGKWRYPYGYGAELPDFAFDSVPYVDLLLNDLGLKVHRKQSRLMELVAPYKPRDYRGLMEEWQEAQHWGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4N3</accession>
    <name>A0A7D5Z4N3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FRE7_2</name>
        <name evidence="16" type="ORF">G6M90_00g084130</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543629.1">
        <property type="nucleotide sequence ID" value="XM_014688143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4N3"/>
    <dbReference type="GeneID" id="26243806"/>
    <dbReference type="KEGG" id="mbrn:26243806"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="296"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI72725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="632" mass="71010" checksum="4409058831CF2870" modified="2021-02-10" version="1">MSAAWLTPPITLTGSRDFACDSFGFTEEQCTYYQERWHFWFIADYVFALSTIAFLMSVLGIFVIGNFVAQLLGYRAWRASSPWKRAIALTRYLSYRGFHVEALQWNSAPLGLLLLAAAGTVFFLCMDLIPEPYYWPSLGFGGSPPLGTRSGWMALACMPFVFATATKTNWITLLTGVSHEKLQVFHRWISYVFFLLALMHTFPFIVYHIRFGDMIMQFEMGLLFYWTGIVAIIFQAWLTFASHSVIRNLGYEFFKATHLFAAAIFVLIFFWHCDYTLTSWHYFIATAAVYVPCYVYPWLRTCIEYGTRVKAQVTVEENGFTRISIPANFTWVPGQHCFLRFTSFGFLQAASAHPFTICSLPYRQVNKKSELVFYIRHQRGFTARLNQFALNHPGALLPVLVDGPYGGINIQAYAHSDNLLIMAGGSGAGWTLPFIEQFVLRQSKAVDEGPGQTTDLDSVEKETESQERRTSRPFTLRVILATRDTASRKWYLRAVDELLSRYSTSESLSNISIHLHLTGKAAQEVGLADKAQDLPAESSSSPDGITAQESTTHSPVLATLAKQLDGRPQLPLVIQEEAARVADACESLSVFVCGPATMQNDVRNAVAEANLKVLKGSKSGGVYLHSEHFSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4P4</accession>
    <name>A0A7D5Z4P4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g051710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539479.1">
        <property type="nucleotide sequence ID" value="XM_014683993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4P4"/>
    <dbReference type="GeneID" id="26247704"/>
    <dbReference type="KEGG" id="mbrn:26247704"/>
    <dbReference type="OrthoDB" id="10386865at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028951161" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="11940" checksum="2A31E1DFAAA901F9" modified="2021-02-10" version="1">MKTSIILPVLLNLALASAARPLGPGEQTPETLLKENAQLDINCKLENGGVQCATDRGSNPRKENLLQLCDQIGGCVCGPLLGNRFGRKRFGGNDSWFDFFCSSSQKEQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4S8</accession>
    <name>A0A7D5Z4S8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g034550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986243.1">
        <property type="nucleotide sequence ID" value="XM_066130153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4S8"/>
    <dbReference type="GeneID" id="26239415"/>
    <dbReference type="KEGG" id="mbrn:26239415"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF2">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G04300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="753"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="849"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113967" checksum="5F0F1B9A47D02D3D" modified="2021-02-10" version="1">MSVALTATAVPVVIDLTLDTPTTVTPLTSPYNHGDPTQQFQLASQQPPAKKRRVENDGPGAEHVEMRMREYLLPYVQKAVDELARDACLVDTIAIEAVTTLLKSARFREKVQLSNGLLTAEDRADIEGLATQAVQQLAGLTQYRRPQPQPIKEEAPSSALVRPKLTLRAEQRAFQRLESAEPTSKPDTGPTRVPRPRVRRQYVVPKSSDGLPTASTWLQLQRRPYLHYSARQDITLGVNRPVNVARHRVQLPAVYHADFSSLEIAEIMKIVGQHLSQHIPRTREGLEQILRHYNVPRIIGDSISGRTQQDIYNLCSDLCAGKASQPDNSRVLSLEEVSPERRARNRRANRLPALLLAREMEGNVGFGRMRRYENFQNEFQKCHEDGLSLVAEFTNCAGDISAMSWVPDGNIICGTTAHSDAHNQQYNKPGNLLLCSTERGTLRAFPDHRIPRPFVEKGENSTEAMRQSQDPWLYSSVVSTDYDEMNGRAFTSSFDKTVKVWSVAQDGTSMQATATWHHQGNVNFVVAAKDGSGRVATAADVPTQAIRIYTVDPNNVQDSYYYTISCTRTDADGSDKWAYCPATMQWGQTPGTHHLLAIGYSPRSFTGDDADIPVDKLHSGEIVLWDAERRCRVPVLTVTTANVFEIVWHPILPVFIVATSPSGLIVEHGVRTHVHIFQLDRDREDGAYSEYQKLDCYASDINELTIMPNSLCHSYISAACTDGRVYIWDTAQGDRPAHILKHGEPLGAVICDREKEDEGVKFTAWGTTPDRFYTGSSDGVVKVWDVRRKRRPFVRNLLEGPGPITCGVFSPNHNKLVVGDATGRVFLFSVDDRDEMDSHFLTIPGTNRRVRRPKPFIPHPEPEPPTTSSPFPASTPSDASIAQYSRDRYLSSNSLILHPNPVIGAVQGPAYASTGLFRLDAHAYFDPQGPLLPEFERNQRAAREASLGPETRSIRRLKGPPVQTWVEKSLHDENVAKDFDSRSLDNWSFCQLVNLGVRFNMDGDEGWEFMYEETPVDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4T9</accession>
    <name>A0A7D5Z4T9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRPL44</name>
        <name evidence="7" type="ORF">G6M90_00g101650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546180.1">
        <property type="nucleotide sequence ID" value="XM_014690694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4T9"/>
    <dbReference type="GeneID" id="26240603"/>
    <dbReference type="KEGG" id="mbrn:26240603"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000260">
        <property type="entry name" value="Mitochondrial ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042776">
        <property type="entry name" value="Ribosomal_mL53_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L44, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28236:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="97" mass="10731" checksum="2DBCEBE09DEA3B4F" modified="2021-02-10" version="1">MITKFVTEISAKFNPFSACAKPARLFLTFLPPNARANGTSISTTLLPRNSTEASSVRVKFKDGKELNFDCGKMNIKGLVEEVNRHSRQLQKAADLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4X2</accession>
    <name>A0A7D5Z4X2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g056200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544213.1">
        <property type="nucleotide sequence ID" value="XM_014688727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4X2"/>
    <dbReference type="GeneID" id="26242625"/>
    <dbReference type="KEGG" id="mbrn:26242625"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="142"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55051" checksum="C2299BE9BD81123E" modified="2021-02-10" version="1">MPHLVANFLRTSSGNISHIKKSAITRSRTTSRNNSVSASPYASDSEDHAQHSVKMPELGDALKKHRLSLHFGRSSRHDGAAGSSHSASSGGPHAPASMDWSIESPPIVFYGSPEESTGALVSGLMYIDVHADAIEVDSFTASLTMHVTQKKPFQSHCADCQTKVTELKNWQFLAHPTSLRRGRHQFPFSTLLDGSLPASTDTPIVSISYHFKAEAVAVRGPASTSCLPIRFERPLHVKRSLPEPLYPHHSVRVFPPTNIKASAHYTAVIHPSGSNAVTLKLDGLMTHNERVKTVDLWKLKKVTWKLEETIKTIAPACDRHAPASSAAAAADADDNEAKRGAPRTETRILGEKQLHEGWKSDYSGNDGTVDFEFDYAVNQPRTHGKEPRYACGLKTQDGTEVSHALHIELIVSKEFAPEGKTHLAAQTGTGRILRMHFAVNLTEYPGLGVSWDNEAPPVYQDVPPSPPAYPAEPPIEYDDLEELDAQRTGSTPGSRRHSESGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z508</accession>
    <name>A0A7D5Z508_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA ligase azaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">azaF_2</name>
        <name evidence="4" type="ORF">G6M90_00g111350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543729.1">
        <property type="nucleotide sequence ID" value="XM_014688243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z508"/>
    <dbReference type="GeneID" id="26243116"/>
    <dbReference type="KEGG" id="mbrn:26243116"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="445"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="545" mass="59941" checksum="7A2520F16F90C0F5" modified="2021-02-10" version="1">MFKASRQIDLPTKDILSYIFDEPDYDQDKPIYVDTNDSTRTISCNQARVIIRQLIAGLRAAGVKPGDCIAIHSFNDISYSMLVLAIIGAGGIFTGTNPAYTAGELSHHIKTSRCSFLISEPEILNPLLEAARDNKIPDDNIWIFNPLGQQVPAGRRPWTDLLKHGEQDWLRFDDHDVSKSTTAARLFSSGTTGLPKAVTITHYNLIAQHELVVKADQRPYEVSRVVATPIFHAAAAPGTHVSALASGHVVFMMRRFELKAFLHAVETFRATELGLVPPIAIAIVTSPYATTRPFLATVRNARCGAAPLDKQLQARLQHLLSNGAALTQVWGMTETSCVATMFPYGEHDDTGSVGRIIPNVELKLVGDDGREIRDYGVRGEICVRGPTVTPGYFDNNTANAESFDSEGWYKTGDIGYCDGETRKWYIVDRKKELIKVRGFQVAPSELEAVLISHPQVVDAAVVGVALPGAEGEFPRAFVVRRPGGEGLRLDERAVREYMESRLARYKALTGGVKFVDAIAKNASGKILKRLLREQSKNELEVSAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z516</accession>
    <name>A0A7D5Z516_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pierisin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g111710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543696.1">
        <property type="nucleotide sequence ID" value="XM_014688210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z516"/>
    <dbReference type="GeneID" id="26243083"/>
    <dbReference type="KEGG" id="mbrn:26243083"/>
    <dbReference type="OrthoDB" id="4868762at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054695">
        <property type="entry name" value="Pierisin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22596">
        <property type="entry name" value="Scabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028946677" description="Pierisin-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Pierisin-like" evidence="3">
        <location>
            <begin position="104"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="51783" checksum="18E1E039EFA96243" modified="2021-02-10" version="1">MRAYQLLSLSAMLSSAASWGIKRAALEPNLDLSVDITNDINIDPDIIGKALFEIIPDEKARNEDNPISRRDVFSRQEPGNPTLRSAEEVSKIKAPGTSKSGVFYRGDSRPPEEIFKSGFKPQGENTNLQNHLDFKPNSGLVSVSRSREATYGYMFGRSADKNPKGYVYVIAAKDMPNGYWVPGIHPPEKNAAVSRNQEFAVNGAIPATSISHAFEVTQANPTDKARKIKNEAYSLRSASKCTIMKRRAGGSCDPAGWVDIEKNEPKKPASGDGGKGKKPVGQKISQSKFLQFITELEPKSIGGLIKVLKDGEATIADVQLGFKRALSEAMDNRWADFGDWDKAAESLKNIVVDVASTVRYATPAGYWSDVIKRLPDIAKEISKGKTPKEKLEIANKKVNGAVNAWAYTPVGFVNEALMREAAMRTPAVQAVAISINKLWSYTPLGWLINQIAPIESLRRKINAREEVLSLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5U7</accession>
    <name>A0A7D5Z5U7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543222.1">
        <property type="nucleotide sequence ID" value="XM_014687736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5U7"/>
    <dbReference type="GeneID" id="26244023"/>
    <dbReference type="KEGG" id="mbrn:26244023"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="567" mass="64712" checksum="33D384DA43093F9D" modified="2021-02-10" version="1">MDAFLATLSPWDLLYLRGKFRSGIPITGLAGLPDLPAEVISLIVIELTLDDIVNCRLVSRDWYSSWTQGPVITALSHFFFPGLIEKHKQLSNLQSPHRLVQASVANALRRRHSRPSRTSFILWREPRCPVFRRPGEEAEEPLDCRRLSFDVPGPTAFYDRGRLAWQANKLKIVVDDLHTCERHDCSLTEMHLHGQELTLQGMSRELLVFIAKRVGAGSNYNTMQIWHTDLKDWRRVTLPGPLTRCYVQGERVAFFTRQRLLVAWSWRGGASEIDISGEMNQPPEDYEGRRSFPGVILHPEKPDTLYVASIFRSKLNPGITEQSQKLRFLMSVVRYEDGKPTERWQELIQEDSLTDHFFISPHVFFQVVLLCPKMGPNGLYNLGTVLTSINVTYDEARLGEIYSGQVVELATTAFSIYKESFIQRRFVRCAGDSTIYCLPMQYEPSLYGLCDCEEPLTTWSEEHPSIPRWVELDTDSRRLDADKAAEDGIVLYLREVKCRLELELCLIVGDEDFQIHVTSEGILVWSFTEGTRLPAMDGPESLRGAKNEPSTLSTPVRPIHLLPFVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z708</accession>
    <name>A0A7D5Z708_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neutral ceramidase</fullName>
            <ecNumber evidence="4">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDase_1</name>
        <name evidence="8" type="ORF">G6M90_00g055030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540902.1">
        <property type="nucleotide sequence ID" value="XM_014685416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z708"/>
    <dbReference type="GeneID" id="26246208"/>
    <dbReference type="KEGG" id="mbrn:26246208"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF20">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028952099" description="Neutral ceramidase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="59"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="581"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="743" mass="81970" checksum="25D324E45A510AFA" modified="2021-02-10" version="1">MELQSFVSWLLGLFVVFLSSVPGVLALPGSFPEAHGPDWSKIHSRFAARSQKNSTQDKYLIGTGKADITGPAADIILTGYANLEQVGGGIRQRLFSRAFIIGDVNNPEDRIVYVVLDNLVGDTAIRFGVLDALKGMGAPYSVYGQNNVALAAAHSHSAPGGWNNYLVPQIPCLGFTKESYQPIVDGAVLSIKRAHESLQEGYLDVGTTEITDASINRSQWSYLQNPAEERARYSASTDTTMTLLRFTRASDNKITGLLNWFPVHGTSLYRNNTHVAGDNKGLAAWMTEQAMREDSAFASNFVAAFSQANLGDATPNTEGAWCEDGSGKQCDFETATCADGTVAKCQGRGPHWQVQDQGASSCHEIALRQLRGVKDILTSMSKSSTPVQGPTVKSFHFFHNMEYWQFTLPNGEAAMTCPAALGYAFAAGTTDGRGEFDFIQGDNGKPHNREWDFLTHLIKNPSQRQTDCQKPKHIFLSAGELKDPYEWEPSIVDVMMFRVGQLVMILSPSEVTTMSGRRWKEAVGKQATSFVDDPIVVLGSPANTYAHYVATPEEYDVQRYEGASTIFGRHELDAYINLTVSNMHYLKPDATEKPEQGQLPPDNRKKSLNFVLPVIYDTAPLFKQFGQVLTQPQARYKRGDVVKAKFQGANPRNNLRLEGTFAAVEKQGQDGTWSQVADDADWYLVYTWRRTSTLLGHSEVDFTWDTSGNAVPGRYRFKYYGDAKNLDSGIAAFTGTSNQFDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Y8</accession>
    <name>A0A7D5Z7Y8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HEM13</name>
        <name evidence="7" type="ORF">G6M90_00g072720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545791.2">
        <property type="nucleotide sequence ID" value="XM_014690305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Y8"/>
    <dbReference type="GeneID" id="26241824"/>
    <dbReference type="KEGG" id="mbrn:26241824"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000004">
        <property type="entry name" value="Coproporphyrinogen III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="348" mass="39908" checksum="4413B7903393D1C3" modified="2021-02-10" version="1">MAHHDSQPQATTNGASLDATTLAEKDAQKKREATINEDSPMRLRMEKFIKEQQQVIVKELEKVDGKRFRKDEWTRDNGGGGISCVLQDGNVFEKAGVNISVVYGSLPKPAIQKMHANHKMLDPSVESLDFFAAGLSMVLHPKNPMAPTVHLNYRYFETANPDGSSQAWWFGGGSDLTPSYLFDEDAIHFHKTLKSACDSHDKTYYPRFKKWCDEYFYNKHRGECRGIGGIFFDDLDDSERDQENTFAFIQDCLKSFIPSYLPILEKRKDMPFTAEEKDWQQIRRGKYVEFNLVHDRGTAFGLNTPGSRVESILVSLPLTASWKYMHEPEPKSREQRLVDVLKDPKDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8R7</accession>
    <name>A0A7D5Z8R7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g071360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545923.1">
        <property type="nucleotide sequence ID" value="XM_014690437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8R7"/>
    <dbReference type="GeneID" id="26241956"/>
    <dbReference type="KEGG" id="mbrn:26241956"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="669" mass="74929" checksum="ACA02516C9756AFD" modified="2021-02-10" version="1">MPGSPAGGPLQAVTPDRVNRCDSIFSSGRGEARDSSVHEKIHQFNNLSIAMQSKQMERKTADAALKRAVVGREEAEAELKRMRDELMLLRKDIEEGKERERKVGERLETVMDNYGRAKETHAHTQALWEKEIRRARKENFKSQSTIVKLQEELKSARSSVKSVEESLQREKERSKIREQEAFTARYQIVGVQEQLDKALERIKIVEQERDAFKTAAKNEEVARIAAEGRLPLPPSQDLTDEFSSPKKKTIPAKRQSGRAAPRVSLSTMEIMSSVASEMEIEELNTQLLWERQRAERAQEMIEFLQAECQMRCCPCSKTNNARMSIEAPQKRRRVSVEQGEEQHPVVVKEESHSPHSPHSPHSRRAPSRNSHGSSHRGSLRNSARLEEYRQEPQPEPAREPEQEEPLVEPEVEPEQQRIKSRKEPRRSTIFCPKEGIFRTVSEQEAAAMQAQERCAVAVEPAIEEEAQADEPLPSTEVGHSPRMYARTPSVDPPSFALLAQERNSLDFLLDAPHDDAQSAPLPPIPSIPVVADEEPAREEAVGSVEQSYSPAGSPEPRPHTSTASFTVTTTIPLREETARSSSSFNERLRTPSHGSNASFDSNDPAMTPTMTREQALAKIRERRGRARSAAQGTAAPRKKVAAVATGPRGRPAKRDVSAPTVKATPRFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9F7</accession>
    <name>A0A7D5Z9F7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g079230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987202.1">
        <property type="nucleotide sequence ID" value="XM_066131115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9F7"/>
    <dbReference type="GeneID" id="90968013"/>
    <dbReference type="KEGG" id="mbrn:90968013"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028957649" description="Sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="32"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="420"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="550" mass="61315" checksum="0F628DEA81D9AEE6" modified="2021-02-10" version="1">MLNKPPMQGGGGKRHVVLALLVSALFSNVGANPSHYRIASWPRAVQSRWAMMRDERVSRGHLTAPKTDARTHGHDDLSCGIPDESQRMWFTQGGCSIASQDLTYVDTSGEVPVVRTAAEGHLVKLTCEDVFCPIPPRLDCYEQPGICSANEWCMIDIHERWGPWAMNRDGSTPQWEYCYKAADFVGNSSDQALIDSYYSECVASTIGDYGIKLGPKIEAWKPIRGRCVKFRQAEQSCIGNPLEFGAYEREFGLNYRREQDGAPFPRPLVCGPELTCTGPDFDVRPSTCVHQRPQDICFAGPWWDSTQCPRTEPEAPRGGLTREQTVETLRRAVLLYPGEIATAADCAYWNRSSAVGISVLATQHRFYNIAAVLWPTDLFGEIPSFDELMALIPDPNLFGSPADCVAQADIPGSEINEALAEGGTLSNQPNQVWSLVHFLMHNQPIVLSSKKIAASRAMAAHLSESFWCDDCRGFFSVGVIERYGLPPESSNPDDQARWWWWGHNVASEHVASTRGGHPWIHELGDEGVAYFQNPYFMTWEDAVAEWTYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAE0</accession>
    <name>A0A7D5ZAE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g078150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545292.1">
        <property type="nucleotide sequence ID" value="XM_014689806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAE0"/>
    <dbReference type="GeneID" id="26241325"/>
    <dbReference type="KEGG" id="mbrn:26241325"/>
    <dbReference type="OrthoDB" id="5428040at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="718" mass="79731" checksum="85BAA8EAB2795F50" modified="2021-02-10" version="1">MAPRRVATTSSHDYVSLVPLPPPTEEDDDGEDVGQRPPKPKKKKTWQRFGLMSFIILLLGSAILLLVLLILWILWKSSMRAADGGPAETPWVYIFRANRVTTLVALCTAGLRTVIGLQSSVATGMLAGIILETVGAPLLKAPFYSIIRAVSVGPSNLLSTVRSRPKDATSFLIYTLVVLEVVLTVASQFLSAILTTDFAEGTFANIDNSTDVRIFIHKRIRLDGINANYWELPPAASWTFAESSEPFTKGASFDDTGHTYRAFLPFEDEAQRTRLRKFRGPAHVIDNRVVCAKPSLLNLGLIQISNAPRWALSGQIAMETTIYPILKEAEPENYINFTCALVTPTVYTEVTAGESSLCAVDSKNWTILLEDPLVVPAVDDGINISPNEVGHPKGSRMFMILDIVSASPILRITHNQDCKVVRNDGPWVMAAGEEATETLRITACMTNLTPKTFIVDIHSAWDNPEPRLTWDYEAKRYNTEAARHQLGASLIPESFETRRVLTLSPRSQWQDFPNKTGMWDTTFYFDEVLEDTLRRSDLENGSTDAGIILSEGNQSIDKNAYISHIHPFQDTLHDTKSPALALQVLLARITQMVYYVDFLRLDNKSEALVSFSSTALIPMKWTGLIAATALTVTHLAVVVIVTILYLKCTNESLLGSSWQAISQVISDETLPILEHADRMNDEDIRRWAKGQFLDARNHQVIRCRSTGRVCLGNKGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBQ6</accession>
    <name>A0A7D5ZBQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g106190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539609.1">
        <property type="nucleotide sequence ID" value="XM_014684123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBQ6"/>
    <dbReference type="GeneID" id="26247606"/>
    <dbReference type="KEGG" id="mbrn:26247606"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="30"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="115"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35704" checksum="A696DDD7EE8DAF11" modified="2021-02-10" version="1">MRRQSTVTKHNIVVLDDCFAPCAQFDFDYVITYYSSTEPHQLPARIEDATIVIVTDTRVTREGILGAQRLQLVAANGTGTDRIDKTALRELGIGLCNLPAQTTESVAEHALALYYGLRRNLLEMHAITMAGKAWATCGNTQIRFQRSTPPPRTNAEETMVVLGYGTLGKKIESLGKALGMNVVIAERKGAQETRPGRLPFPQCLKLGTIFVIAAPLNETTQGMIGTSELAAMDPTSLVINIGRGGIIDELALAHSLRKGQIGGAATDVYEIEPATTANSPLLDPTIPNLLLSPHTAWYSKRSIDNVLLAQKLNLEAFVAGNMTNVVIAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBW6</accession>
    <name>A0A7D5ZBW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">G6M90_00g088560</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542258.1">
        <property type="nucleotide sequence ID" value="XM_014686772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBW6"/>
    <dbReference type="GeneID" id="26244772"/>
    <dbReference type="KEGG" id="mbrn:26244772"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="326"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="18">
        <location>
            <begin position="556"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI72329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="618" mass="67977" checksum="8BA0CB5B83F2438E" modified="2021-02-10" version="1">MADSSPQLAKLRSLMKERKVHVYVIPSEDSHSSEYIAACDARREFMSGFTGSAGCAIVTLEAAALATDGRYFNQAAKQLDGNWTLLKQGLQDVPTWQEWAAGQSAGGKTVAVDPSLLPGSAAKKLNDQVRKAGGADLVPLDENIVDIAWGDSRPERPCQSVSVLPDELAGKPATTKIEELRQELAKKNCPGFFVSMLDEVAWLFNLRGNDIPYNPVFFSYATITPEVAILYVDESKLDESCRAHLRENNVQVKPYDSFFPDARQLHTEVKAKRQAGGDGVVVGNFLISNKASWAMSRALGGDGSVEEMRSPVGDAKAVKNETEMNGMRACHVRDGAALIEFFAWLEDQLADKKIMIDEVQAADKLEELRSKHQHFVGLSFPTISSTGANAAIIHYGPEKGSCATIDPGRVYLCDSGAQYRDGTTDTTRTLHFGKPSDAEKKAYTLVLKGLIGLDTAVFPKGTTGFALDCLARQHLWKNGLDYRHGTGHGVGSYLNVHEGPIGIGTRVQYTEVPLAPGNVLSNEPGYYEDGNFGIRIENIMMVREVQTEHCFGDKSYLGFEHVTMVPYCQSLIERDMLTADEKAWLNAYNDEVLKNTKGFFQGDDLTIAWLTRETRRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPG0</accession>
    <name>A0A7D5UPG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g009030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549607.1">
        <property type="nucleotide sequence ID" value="XM_014694121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPG0"/>
    <dbReference type="GeneID" id="26239051"/>
    <dbReference type="KEGG" id="mbrn:26239051"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="255" mass="28677" checksum="7BDD9D418587CFCF" modified="2021-02-10" version="1">MPPEGIDAVTSRAARHDLARRLSHLARRLTYDGSDDVDEMMVGSQLEQLEKVVGGARSAESKKLPYRTSFDSPGRSDAGSVLGSPVSSLFRSRFSDLSASLHREREAEKEPEDEAPSKKGMTGTQAKKVIAEMSKLNEELSTVVNNLKARQEESEHIQGLLIERAERAAQRIIFLQNRISYLEEELQENDGELQHLRICLKAVEIQMPPHPDKELQRCIATFKDDYQALKRKRAHRASMASVRGFDPLQMGTPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPG2</accession>
    <name>A0A7D5UPG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GDP-mannose transporter</fullName>
            <shortName evidence="12">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">VRG4_0</name>
        <name evidence="14" type="ORF">G6M90_00g000690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasmic vesicle membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542999.1">
        <property type="nucleotide sequence ID" value="XM_014687513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPG2"/>
    <dbReference type="GeneID" id="26244372"/>
    <dbReference type="KEGG" id="mbrn:26244372"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI63517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="381" mass="40951" checksum="984187C6E1FE16CD" modified="2021-02-10" version="1">MSDKKSDDMLPMSNSNGHANGVANGRNGSAHKQPFPSFTPAQAKTDALKGLGPSMASLESSRGASVIAYCLSSMSMTIVNKYVVSGSNWNMNLLYLAVQSIVGTLAIIMCKQAGMVKDLGPFDSQKAKTWFPIALLLVAMIYTGNKALQYLSVPVYTIFKNLTIIVIAYGEVLWFGSSLTPLTLVSFIMMVFSSVIAAWADARSASTAAAVTTLNLGYGWMGINVFCAAMYALSMRKVIKKTGFNNWEVMYYNNLLTIPVLIISSLLVEDWSSANLNSNFPADSRYSMCTGMVYSGLGAIFISYSTAWCIRATSSTTYAMVGALNKLPVAILGILFFAAPVTFGSVSAIVLGFVSGIVYTVAKLQKGKEKPQPALPLTNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPH3</accession>
    <name>A0A7D5UPH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dicarboxylic amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DIP5_0</name>
        <name evidence="9" type="ORF">G6M90_00g009200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985578.1">
        <property type="nucleotide sequence ID" value="XM_066129662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPH3"/>
    <dbReference type="GeneID" id="26239034"/>
    <dbReference type="KEGG" id="mbrn:26239034"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
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            <begin position="105"/>
            <end position="564"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="588" mass="63056" checksum="40DB6E32CD65D62E" modified="2021-02-10" version="1">MALKSFLARVKGARGNHAAIVDSNGAKGYGTTTTTPLPGPADDSGFASNVERQDAAPGVIRTTPGPPLGYNDGHDPGDDGDDDHAGDLVTAGEGRHLKRGLAERHLSMLGIAGAIGTGLFLGLGGAVQRGGPLGALLGYATVGLVVCAVQFALGEVAALLPVTGAFVRHAEFLVDPAWGFAIGWNLVYGNILSIPSEITAICVLFEFWTDLNPSVWIVTFVLLTLVVGLSVVRLFGEVEFAFAVLKILLVVFLVVLGLVIDLGGVRGTPPVYFRYWRDPGPFVEFIATGHWGRFLGYWSVMTGAVFSFAGVESIAMAGAETKNPRKAIPAACKNVFIRIVLFYMLAILIVGMLVSSQDSRLDSESGDATQSPFVIAASAAGIPAIPSVVNAVVITSAWSASNQSLLAGTRVLYGLAVKKQAPRIFLRTTSWGVPYACVFLFMAFSLLSFMSLSSDAITVFWWLVNLTAAGVLVSWISILVNHIRLRLAMQKQAIPITRLPWSNSWTLYSSYFALFMCIIILLTGGFAVFTKGNWNASNFVSAYLDIPLVLAAYFIWKFVKKTKIVALADIPLQRAFERADQKYESLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPI7</accession>
    <name>A0A7D5UPI7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">chsD</name>
        <name evidence="11" type="ORF">G6M90_00g007550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549755.2">
        <property type="nucleotide sequence ID" value="XM_014694269.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPI7"/>
    <dbReference type="GeneID" id="26239199"/>
    <dbReference type="KEGG" id="mbrn:26239199"/>
    <dbReference type="OrthoDB" id="5321960at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF46">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="687"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="710" mass="81290" checksum="36F29A657CED39D3" modified="2021-02-10" version="1">MAVTIGDWPLKDVIYTIIVGLLMLMACFEWFLWLAAFMYCLIKVFGKAEHWSIRALCLVVGSAFVLLRCIFLPIMIVTLPLPPAVANWWPETVTSFLQWFAFWSFSILLTVPWLFCIYQLVTNHLGRTKRIKRVLDDYTAPKVVVVMPCYREEPNVLISAIDSVVECDYPAPCIHVFLSFDGEQVDELYLNTLGLLGVPTTLDSYPNCIDVIYKGVRITVSRFSHGGKRQCQKSTFELIDRVYADYIKQNDNIFILFIDSDCILDRVCLQNFVYDMELSPGNSRKMLAMTGVITSTTKKHSIITLLQDMEYIHGQLFERTVESGCGSVTCLPGALTMLRFSAFRRMAKYYFADKAEECDDLFDYAKCHLGEDRWLTHLFMIGAKQRYQIQMCTSAFCKTEAVQTYASLVKQRRRWFLGFITNEVCMLTDWRLWKRYPALILVRFMQNTIRTTALLFFVMVLALLTTTASVRNLPVGFMAVSLGLNWLLMLYFGAKLKRFKIWFYPLMFVLNPLFNWYYMVYGILTAGQRTWGGPRADAAAADMHTTAREAAEQAERQGDELNIVPETFKPAKEARAIVRENQGPGIPIVRKRSVVRPPDVVDGQFSGPRNIKGTMYTTRRHLQHAEPISEQANPWPAYDADGTLTHGGEGDAYMSDEDKRKYAIAHQARRLRLEQRPRTGPGLNARWHNSPQANETSQGRNQVDEVGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPR7</accession>
    <name>A0A7D5UPR7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g011610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549362.1">
        <property type="nucleotide sequence ID" value="XM_014693876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPR7"/>
    <dbReference type="GeneID" id="26238806"/>
    <dbReference type="KEGG" id="mbrn:26238806"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61248" checksum="396B34A8CE2D24F3" modified="2021-02-10" version="1">MQLTNARLLASICGVSAHVLVFRVGEWDLASPSIFVFHALLVVTALFASRVQLLGLSVSELMTCLGYYVAGLYASMMMYRAYLHRLCKYPGPVLASLTNFYITARSVSKFQLFKEVQKLHLQYGDYVRLGPSELSIADPKAVEAIYGSKSPTTKGPWYTLLEPRTPVFMVRDKREHARRRKTWDLAFTTKALHGYDFRITKAITELLQVVDRHQEQPINMTTWFSFFAFDVMEDLAFNKTSHMLRHGRESYIFKTMRGDMYSIAFFSHLPWLMPFLKRTPVLNSNYLKFWRWIQNQIDERIKNTPDWPDIFSFLLADFNRGSKTQQERWDLHGDAQLIVIAGSESVSTTITHVFFHLAHDAHLAHALQRELDMLPGLAHDNLLKIPLLDAVIHETMRLHPAVPSGTQRVTPPEGLTIGERHIPGNTIVQVPSYTVFRDARCFVQPNDFIPERWTTRPDLILDKSVFIPFNIGTSACVGKRLALMEIRRVVAELFWRYDVGIAPGHTKEAFLEGKQDTFTLMSPPLPLVFTPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPZ1</accession>
    <name>A0A7D5UPZ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">chi2_0</name>
        <name evidence="20" type="ORF">G6M90_00g029400</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541230.1">
        <property type="nucleotide sequence ID" value="XM_014685744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPZ1"/>
    <dbReference type="GeneID" id="26245865"/>
    <dbReference type="KEGG" id="mbrn:26245865"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028800092" description="chitinase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="19">
        <location>
            <begin position="35"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI63798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="43601" checksum="80D54599D5ABD0F9" modified="2021-02-10" version="1">MHHLRALVGVGLAGLAAGVPLTDKTSVKPRQAPGAQNVVYWGQNGGGTIENNDLAAYCQPNSGIDVLVLAFLYQFGNGGNIPSGTIGQSCYISTSGQGQNCEALTAAIHTCQSAGVKIILSLGGATSSYSLQTQAQAEQIGQYLWDSYGNSGNKTVQRPFGSNFVNGFDLDIEVNGGSSQYYQYMIAKLRSNFASDKSNTYLITGAPQCPIPEPNMGVIISNAVFDHLYVQFYNNNNYTVPCALGINGNAPFNYNNWTSFIADTPSAGAKIFIGVPASPLASTGTPSGAQYYAAPEQLAAIVGEYRSDAHFGGIMMWSAGFSDANVNDGCTYAQQAKSILVSGAPCASSGPPSSTPATAPAPTATTMPSSTSVSSPTASPTGGTVPQWGQCGGEGYSGPTQCVPPYQCVKQGDWWSSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ14</accession>
    <name>A0A7D5UQ14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-sulfolactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comC</name>
        <name evidence="3" type="ORF">G6M90_00g017980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548735.1">
        <property type="nucleotide sequence ID" value="XM_014693249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ14"/>
    <dbReference type="GeneID" id="26238179"/>
    <dbReference type="KEGG" id="mbrn:26238179"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="37486" checksum="AA412978786618D4" modified="2021-02-10" version="1">MAPAEDSATRHVSPSEARRLVQDILTGNGVPGENAALIAKCLVAADLRGVDTHGMNRIPSYMERIRRGVLDAAAQPAIDQVTPAVAQVDGRNGFGFVSAHQAMRAAISSARVYGIGMASVKRSNHFGMSAWLVQQALDADMMSLVFTNSSPALPPFGGRSKLLGVSPIACGAPGEPDFILDMAPSVAARGKIYKAQRRGEAIPAGWALDAEGRPTEDPAAALGGVMLPMGGPKGSALAVMMDVFSGVLSGAAFAGHVTGPYDPSGPADVGHFLVAVKPDLFMGLDEFRGRMKYLYERVVGADRAAGVDRIYFPGEMEQRTQAERERTGIPLVQAEIDALNAEAARVSAKPLVFMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ55</accession>
    <name>A0A7D5UQ55_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549812.2">
        <property type="nucleotide sequence ID" value="XM_014694326.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ55"/>
    <dbReference type="GeneID" id="26239256"/>
    <dbReference type="KEGG" id="mbrn:26239256"/>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="44944" checksum="51469CE5D2B2FC1E" modified="2021-02-10" version="1">MAMDALRNLANNIPDWQRRLDDLNGQIERRQAELAAIARTNATSTDSSRPLRNKGSSESLKPKDDGPMHPDLDLAVTPSQGQRKRIAPRTPPTPSGEAKATPASPPSPDSESRVALHRQAREAVNAHARALAQTKKKQKSSSVLSADGVPPTYRTRSMIMVYYDSYVQGFFDELVRFISSSRNLMRKAKMAAKVAQIKRMAELEIANDAKRTSDERFAVDAIPSLRYMSTRKVGTTSQELTSGEPSRPAGPEQPADVYDSLDKSLEFVQSTCEHGAHQFLRDADCHDEIGKIQSRLVEVLIAAKQEIDRVQREDPELAKETGELGKVRLHRPISVRRDMTAECKDEVSHNDGCLTWEISPEKDATLQTEMALEVDTNLEEEDMDNLPVLQYRSTRLMRSRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ92</accession>
    <name>A0A7D5UQ92_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">AKR1</name>
        <name evidence="16" type="ORF">G6M90_00g016980</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548833.1">
        <property type="nucleotide sequence ID" value="XM_014693347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ92"/>
    <dbReference type="GeneID" id="26238277"/>
    <dbReference type="KEGG" id="mbrn:26238277"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="455"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI64255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="733" mass="80597" checksum="CB70CAC343ECC2F2" modified="2021-02-10" version="1">MSSPARPSSKSAASASGASAPPIQFATKSSVASPKLNNEMEMGSLAADGQAGDDDAAVAVSPEKDIMQLARIGDIVAMEKLFESGEFDATYSDDEGITPLHWAAINNQYAMCKFLIEHGAEINRKGGESVATPLQWAAQRCHYYTVNLLLQHGADPLITDAQGYNTLHISTFNGNTLLIVLLLHQGIPVDVLDTFGHTSLMWAAYKGFPSCVDVFLRWGASVHAADEQGFTALHWALVKGNPGCIQKIIEYGADRFAKTESGKTPSVTATELNTQPAWHRALRECGYDREGNPVTPPWPGANYFLKDKRAFTSKFLFFWPWVMIWGVLIVISYAPVFLGLPLAAGVVYCAHWCATQVLEYAPSDMRHFHKTPWMAGIFAGSLFLVGVNWLSTVVWTTIRGESSHMILNLVFGVLFGLTTFFYAASMRYDPGFVPKLNGIAEQRAVIDELLASWRFDEANFCVTCMIRTPLRSKHCRRCQRCVAKHDHHCPWVYNCVGINNHRHFFLYLVNLTFGILAYDWLVYYYFGVVSTDAPASCNVLGPGFCKLINSDAYTLLLSVWVSLQLIWVTMLVFTQLVQVSRAMTTFENMTGIHTREATTALTSTGTPLDPSLAAAATSTTSAGGHGGRHKGGMLKQWSRILGVDPFIETITGRGAATGNSRRKKKNPYSRGCVSNCKDFWCDPAPVFGQRENGTAVLGGGKVDYTAMYESPTLMSLTGMRTRGGYESVETEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQB3</accession>
    <name>A0A7D5UQB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily multidrug transporter FLU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FLU1</name>
        <name evidence="10" type="ORF">G6M90_00g008660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549644.1">
        <property type="nucleotide sequence ID" value="XM_014694158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQB3"/>
    <dbReference type="GeneID" id="26239088"/>
    <dbReference type="KEGG" id="mbrn:26239088"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="146"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="629" mass="68832" checksum="9E5EB1C3995D5D0A" modified="2021-02-10" version="1">MPMDIVDRELADAEADASPGRYRRRASDEIERVLSASSASTSSESNDGDSAFRRNMSRVSTQNDLERHPTELSRIATARSQHNITVGGGLRSRTVSRASKKPLPAFGAGKSYPPPLPEREEYVVEFDGPTDPLHSQNWPMRKKVLTAAMLSYTTLTSAFTSSIFSAATTSVAAEYNVGSEVGLLGTTFYVLGFAFGPTLWAPMSELRGRRLPIVVSMFGFSLFSIACATGKDIQTILICRFFSGLFGACPLAVVAAVFSDMFDNRTRGIAVTIFSMATFTGPLLAPFIGGFIVSSHLGWRWTEYLASIMGFVAFILDLFFLEETYPPVILIDKAADLRRRTKNWGIHAKQEEIEVDFKELIQKNLSRPMRLLFTEPIILALSIYMSFIYGILYLFLTAYPLVFVGVHGFNSGQSGLTFFGMITGQLLAGAVVIMQQPWYNRKLAGNNGIPVPEWRLPSMMAGGISFTIGIFWFGWTGFSSSVHWIVPALSGIFTGFGLMSIFLQALNYLVDAYLMFAASAIAGNTFLRSLAGAGFPLFARQMFQGMGIQWAATLLGCVAVVLAPMPFIFYKYGSRIRAKSAYAPTFAAPAMKNSEDEPGDSSTEKEGENHAALASAPRKESENGVLQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URN6</accession>
    <name>A0A7D5URN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">linB_1</name>
        <name evidence="8" type="ORF">G6M90_00g027950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541365.1">
        <property type="nucleotide sequence ID" value="XM_014685879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URN6"/>
    <dbReference type="GeneID" id="26246000"/>
    <dbReference type="KEGG" id="mbrn:26246000"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="253" mass="26474" checksum="D65693F1F87D797F" modified="2021-02-10" version="1">MSLLGKAFIVTGGASGIGKSTVRKLLELSAQVHVVDVASDIPAHAGLAGRQTNHASVDVASRKHVRAVFDKIAARAQEGVQLGGLVHCAGILRPTEASEAGDEYLRQLWDVNVLGTWNVNTELYRLVRASREASAGARVDALASIVNMGSMASVRGIPDTPGYVATKHAVLGLTRSFAQSWASVGLRVNCVAPGAVNTPMIQGMVLEDVAPAYRGALRSLIEPEEIADTVMFLLGKGSSAITGQVVEVNGGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URQ1</accession>
    <name>A0A7D5URQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein CSF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CSF1</name>
        <name evidence="5" type="ORF">G6M90_00g006260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985906.1">
        <property type="nucleotide sequence ID" value="XM_066129608.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239325"/>
    <dbReference type="KEGG" id="mbrn:26239325"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="2488"/>
            <end position="3216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2544"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2544"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2557"/>
            <end position="2568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="3216" mass="358467" checksum="6A82051F766E7CAA" modified="2021-02-10" version="1">MTAVDVILEARDARLGFNFEFLVFFIICGLLTVFFLLYFNRLFASVVSYAIRTYTWHRYRVYIDIKAIQISLLAGRIFFTGLRYHGSNETFLVQHGDITWRYWLRRVRDADINVSNFSHGSSVSDSQKNSNLPCRIHARLVGVEWFVYNRSPAYNDLLNGLLSDDPSASKSSGISNATQEAGLTSRRGYQNGSAEKNKLAVDATAQAQFSEKPSQPPPSSPPERSSTASQSVSETVDGNDASHSLPAMLQLLPIHVEFQKPAVVVGNDNTKAILIVKANSASTIVDAGPTNTVDPYRQLFKIEFDHPVIEMRENDEFKEDQVARATRRREDTSSLETPAQRSFFRNRRRKVFNSLRNMVPYLRRSVESFSADSRAAMSTGVSQIPGSGHWQGLSRYLDDRYQDDKARWSSVEYGAVNTILDSPSAALTVYWDSVSKITANARRHSSSSFHASINGTEPPAWGMSLSVKGGTVNYGPWADRQRADLQRVFYPTLSKNSTAAVPLAPGSWRVATQFNLFVELEDAVTLRIPTREESKNWRWRGKEPPVGRQAVTGKKRRNRNKKSSKGNAQPARPAGWLEIKVPSNSTVSYSMDMLGRSTGYQNRLDIDLPSTELRSSVNHDLMWKSGPQRISCDLSNPLTWNTLRNWSFNITCEEMKLYLLRDHIFLLIDLVDDWATGPPSEYLVFTPYIYHLKLNLNNLQLYLNVNDENIIDKATAHDDNTYLILSSPILKAETSIPLDKFRPSRNTIPFDIRTDTFDLTLHAPQSNTQAAFLSSNELGHGESLAVTGSYEYNATTSVGNTDTLILDVHGQSPYAYLYGFIIRYLILLKDNYFGDFVHFRTLDEYQEQLQLEAQKSNTDAVHRPPNKKSNDLDVILSVRVDDPRILLPVNLYSASRYVQCELANLSVDLRFTNYYMDLELLLSPLSLSLGCASLSPGSPNSSYTNTQLFVDGVRVFGHRTFGLPPSEPTYLCNWDVSVGMVDGECTADFLTSLAKGGVAFGFMFDDVENALVPYSSLVFHDVTFVRVDIASVRLWLHVDEAAFLLSTGSIQVRSNDWGGTHYSKRANISIPKIEISCVNAESASRHTSRRNHPVDTAAYLKTDVQLASIGRKFHFQQELKIQQDLIRREDQRTGRTPFLLRKPVDPNFVPEPFDPPAQCVPPPAFPLTEVDDDDDASYRSIGTSRFSGRLRRQSSFLSSSSSNTSLRGPRSQPRSRARSRQTALSTQPSGTEKERRVSGQRASVLSQDLRLAAIQQPSQDWQQKEHIEHSSVAFSSQYFAPHFPLGGVRPDGREATFEELEDEPDNDFFGTDASLSDLDPNSLSDNHAQASTMIDFTTGITAFISPEAVRYVNSLLSALQPSEPDDILDSLQTSTIADIFSEKKQSHITGSMQDILIKLPKANIRFLNSSMLDSPDASQEEQDQYDIRISKTLLITRTVKDRTGDNVTSRTSLHFRLKSAEMSASERLSSIETPQAAIMVNIDDISVSLGAKDITYFDADIGSIVGSTASGKVEYLASLIHRTGSIASELGNLLSETASRNNNRTKYLVSQLLEDGHATNDPPFLIRPSAVLRSTHEHMRTVDSWKLMMRLRQIWATLSQSQRRELIDKCRDNPPEAHPDVADHVISSFQKWRSWDLDNPRNAVLMKKIFGKAINEKEEPPQEYPLLGACQLGELQFVLDPGPKQNNIGFLDIALRVDKRPPGQPNVFSEMKDFDGSLTILNLCCAEAAIHLNWELCELAEDVLRLYNKAQPQPSEKTMSSKQPKRKVAQSSAAYHVVFEVVKGSIEAETVNLTAKSIGDGLKTSILLCNSGEELSVANAMLNSNAVMSKLQSHGKILGVLQIQKPSIFVAHELHKTTDIDAHVVKVSASSPNLTLRVKDDPIGLLEVLDLLIRDEAAQVYRLKELIPSPSEGQNKRDKIKQRISTFVLNVAMFLDGYTISIPLLQSLTYKITGSVARASCAANFEKDIVFDFDIKENSHEIQINVKNEPRSISLLEIPPANGRITSNMQSTENVISVLASMEVIRLDASAIYSLLAALNRPQISGAIEEAQQQVKIIQGHVSETFGTHREMKAENASLPTSTPNSAYNIHLTLAGLRILARTHLKTVEEPMAQILFALDKVTLQASTQQDSNSSPLKYPDLYVNLRQISLDISRGKENALRSCGNLTTGINISASSQRGDDGREDWSLHFRNDDLTLNLSPETVSTIVDVVGYMGSKIRDLDTSRELEYLRKLRQSRPKIRINDDEQDWGEETDIFESVLSSITYRFELRNIRFCWDVADGTIDLDYTKEDLVLSIKLIEFGTRTRKSARLTIEDFLLQTVPPGQDKAIRSLHSALLPEVMFNVAYVSTADARRMAFQAVGDSLDLRLTSAFIVPAANLIQSISLSMKNAQAASSQWTIEGPAAVESLTSKKTEDLTPPRQSQRRMFGNKRLENLLVDADFAGAVVYVSTKRNAASAVSESKYSQPSLAGKYGQFSADDSGSGAVLRSPGLAWKAEYRDNGKEDPSLYGEIKINASSNILYPSVVPLVLDILSSVKKVVSDNDANADTEQTPEQLEQPKLKQTKSGDEDNFLTADPSTVLGRLRLNLGLRICRQEFSLSCQPIARVSATACFDSMYFTLITVTSQEQGNFFAISGVIAKPQASVQHVYSRDSTASFELDSVAISFMNSKHFSGTSGVSAILNVGPMKVSVNAKQVQDFLLFREIWYPEELRQKSAVQVPKMPTETSQAHLVQRYQEVAATAAFPWTATISIAALDVCVDLGQSIGKSVFQINEFWVSSKKTSDWEQNLCLGFKKVGVDCTGRLSGFVALQDFRLRSSIQWPQREEALNETPLVQASLAFNALRVKAAFDYQAFLVADITSLEFLMYNVRDGRDGNGDRLVAIFDGEAVQVFGTTTSIAQAVALYQALQKLIEERRENFKSSLREIEKFMKRKSISSRTMLQTPPAVPKLPVDDTLSKSPISLDTDVVVTLKALNLGVFPSTFSDHQVFKMEALNAYARFAASIEQRKIHSILRMTLGQLRIGLAGVRDAEAPKMLNEMTVEDVVQRATGSRGGTILKVPRVEAVMETWQKPSSNHIDYIFKSAFEGKVEVGWNYSRISYIRGMWANHSKSLEQTWGRQLPMTAVKITGVPETEGEQQKITAEVNVPQSKYDYLALEPPVIETPQLRDMGEATPPLEWIGLHRDRLPNLTHQIVIVSLLELAGEVEDAYSRILGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USR1</accession>
    <name>A0A7D5USR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-aminomuconate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">amnD</name>
        <name evidence="1" type="ORF">G6M90_00g022040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548348.1">
        <property type="nucleotide sequence ID" value="XM_014692862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USR1"/>
    <dbReference type="GeneID" id="26237792"/>
    <dbReference type="KEGG" id="mbrn:26237792"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF48">
        <property type="entry name" value="2-AMINOMUCONATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17401" checksum="ED92810DD761387B" modified="2021-02-10" version="1">MHDSPNGKPYFRPSAHAQGLANYPHARIVPSANAHTIYVSGTSSRRGDGTFAGADYKKDESGSTSLQLDIRQQTEAVLSNMSEIIKGATDGKADMNNVVEVSVFLVNMERDYKGMNDEWNRVWPDRALAPARTTVEVRALPRPEILVEMKCVAHLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT72</accession>
    <name>A0A7D5UT72_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLP2</name>
        <name evidence="4" type="ORF">G6M90_00g001110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542959.1">
        <property type="nucleotide sequence ID" value="XM_014687473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT72"/>
    <dbReference type="GeneID" id="26244332"/>
    <dbReference type="KEGG" id="mbrn:26244332"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="71"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="29401" checksum="0F6616078DB21581" modified="2021-02-10" version="1">MAAPGDQRIAVPIDDPNADTEWNDILRKHGVIPEKPPSPTPMIEEAILQGRRLAHENRLEGKDLDELDELEDFEDDEFLDQYRQKRMAELNNLQKKSIHGSVYPISKPDYQREVTEASQKGPVFVNLTSGTGTNVESRVLSELWRQAANEYGDVKFCEIRANQAIENYPDRNCPTILVYNNGEIVKQVVTLVTLGGVRTNMRHIDNLLVEVGAVSESDMRIIKRRQAAEDAEEERLAGKSIKTGTAGRSRNNDEDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT85</accession>
    <name>A0A7D5UT85_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoflavipucine cluster transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AT326</name>
        <name evidence="4" type="ORF">G6M90_00g009410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986125.1">
        <property type="nucleotide sequence ID" value="XM_066129667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT85"/>
    <dbReference type="GeneID" id="26239016"/>
    <dbReference type="KEGG" id="mbrn:26239016"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="464" mass="51411" checksum="C3FF2770013AB6D4" modified="2021-02-10" version="1">MAITMADSIIRKACDRCHSQKLSCKRVGDEACERCVRLQTECKSSPSLRYKKQQQQHGQQYQRQQQRTPYQNQQKPQTQPSAYSTPVSKPPVGRRIPINQQAEDTLSEKQSVVATEASLEPADFDFSQIENLNFFSPPPAASLPHNSVPGGLDTFQPVPTFPDPWDQQLNQAAEAFHATPTSFQPGDNSGFQSAVPTLSLTETPHSQSLAEKRRRPRLRNRPRQIALRQIANAPATHIDPPSIHWMAQLSEINSRLLDLASVLPQQQPAACNFDTLGRSNDEAFANQGFPIDEMFKLTRRVADVLDRLSAGVGASATRMDNSDPGNSMFVLSIYVRLLDMYQKVFSLVRMELSQVDSEALFRFWRLPDVQVGSFAVDPSPSLQMSLTIQLAEEFLARLRVATAALDPALSNGGGSKGVSEDGGSGKSMFSDVVDISFRAVKTKEESLGKHLAELRDEIEAFLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTP9</accession>
    <name>A0A7D5UTP9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DMAP1-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g018190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548717.1">
        <property type="nucleotide sequence ID" value="XM_014693231.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238161"/>
    <dbReference type="KEGG" id="mbrn:26238161"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1660"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1716"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1724"/>
            <end position="1761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1847" mass="203394" checksum="C0AB379EBF227F77" modified="2021-02-10" version="1">MADFHPELQAKLDDLQRELQEGDITEKGYQKKRTLLLSQYGHGESSAPALAPTIHEPPPRSGLRTKQPDDNPPHSSYDGHRASAYNAVRENGSDPGSPIYRPSSGYGTPSTTSQAAETTPAALLRPGGPVAERSVPLQRDSLFITAATASSDDPSRSGTMVSRDYAFNPDQQGAYMDAGHQQQHHHLHPQQQFDGRTRTLQDSQGYFSDFAGQQHYDQTPSGGEYGAPHRYSSGEAFSPTAAMAPPMLTANDLPPPEILEYLQPLEPREVPFAIHDPHDANITMSRFDNLAAVLRHRARTTAKVPAYWVLDSKGKEIASITWDKLASRAEKVAQVIRDKSSLYRGDRVALVYRDSEIIDFAIALMGCFIAGVVAVPINDLQDYQRLNYILTSTQAHLALTTDNNLKTFQRDITTQKLTWPKGVEWWKTNEFGSYHPKKKEDVPALSVPDLAYIEFSRAPTGDLRGVVMSHRTIMHQMACLSAILSTIPGSGPGDTFNQSLRDKNGLLIGNRKAGSEILLSYLEPRQGIGMIVGVLLTVYGGHTTVWFDNKAVDVPGLYAHLISRYKATVMVSDYPGLKRAAYNYQQDPMTTRNFKKGMEPNFQAVKLCLIDTLTVDGEFHEVLADRWLRPLRNARARQVVAPMLCLPEHGGMVVSVRDWLGGEERMGVPLKLEHETTSESDSDDGGETAKPVPPNGFGSLLGGGTTTTTEKNAGNTEMNEVLLDREALKTNEVVVMAYGDEVGKKAPNEPGMVRVGTFGYPIPDATLAVVDPETGLLASPHSVGEIWVDSPSLSGGFWAQPKNTELIFHARPYKFEPGEPTPTPVEPEFLRTGLLGTVIEGKIFILGLYEDRIRQRVEWVEHGHEIAEYRYFFVQHMVVSIVKNVPKIYDCSAFDVFVNDEHLPVVVVESAAASTAPLTSGGPPRQPDTALLDSLAERCMEVLMEEHHLRLYCVMITAPNSLPRVIKNGRREIGNMLCRREYDLGNLPCVHVKFGVEHAVLNLPIGVDPIGGIWSQIASESRANILAPADKQYSGIDRREVVIDDRTSTPLNNFSCITDLIQWRVARQPEELSYCTIDGRGREGKGITWRKFDQRVAAVAMYLKNKVKVRPGDHAVLMYTHSEEFVFAVHACINLGAVVIPMAPLDQNRLNEDVPAFLHIVADYNVKAVLVNHEVDHLIKLKPVSSHIKQSAQILKIAIPNVYNTTKPPKQNNGLRDLGLTIDPAWIRPGYPVVIWTYWTPDQRRIAVQLGHDTLMGMCKVQKETCQMTSSRPVLGCVRSTTGLGFVHTCLMGIYIGTPTYLLSPVEFAQNPMSLFVTLSRYKIKDTYATPQMLDHAMAAMHAKGFTLHELKNMMITSDSRPRVDVFQKVRMHFAPSGLDRTAINTVYSHVLNPMIASRSYMCIEPIEIWLDTKALRRGLVVPVDPEAEPKALLVQDSGMVPVSTQIAIVNPENRMHCYDGEYGEIWVDSEACVKSFYGSKDAFDAERFDGRTVDGDPGVAYVRTGDLGFLHNVSRPIGPGGALVDMQVLFVLGSIGETFEINGLSHFPMDIEYSVERSHRNIVPGGCAVFQAGGLVVVLVEVSRKPYLASIVPVIVNAILNEHQIIVDIVAFVSKGDFPRSRLGEKQRGKILAGWVTRKLRTLAQFAIRDLDVGAIGESGSGSGPGDLADAHRMSTGSIRSSGVHAGASSLRNVEHAPQILEQEELDVQMNRMAHMPPASAPGTASTVTHDDQVTPTGFAQGVSSDTLSQGTLSRNSASQPGYFDDAQRNSEAAYNDDQAPAVGPKPDSSRSQDHPNAAKKRMVLPGVDGREGFQFWDSPPGEDDETDWTAEAIMHMNLAGDMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUQ7</accession>
    <name>A0A7D5UUQ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">uaZ</name>
        <name evidence="11" type="ORF">G6M90_00g041930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547533.1">
        <property type="nucleotide sequence ID" value="XM_014692047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUQ7"/>
    <dbReference type="GeneID" id="26240096"/>
    <dbReference type="KEGG" id="mbrn:26240096"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="33108" checksum="35B72910EBE05E96" modified="2021-02-10" version="1">MPYVSAARYGKDNVRVLKVTRDQTTGVQTVTEMTVCCLLEGDIDTSYTEADNSVVVATDSIKNTTFIIAKQHPVNPPELYASILGNHFIQKYSHIHVANVKVVTHRWIRMDVDGKPHPHSFIKDAGETRNVEVRVSRKDGISITSSIVGLTVLKSTGSAFHGFIRDEYTTLPETWDRILATDVDASWKWAKFADLKAVEESAPKFDKAWDSARNITLKLFAEDNSASVQNTMYKMCEQILDAVPETETVAYSLPNKHNFELDLSWHNGLKNTGKDAEVYVPQTCPNGLIKCEVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUR5</accession>
    <name>A0A7D5UUR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pis1</name>
        <name evidence="11" type="ORF">G6M90_00g049000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986373.1">
        <property type="nucleotide sequence ID" value="XM_066130455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUR5"/>
    <dbReference type="GeneID" id="26242352"/>
    <dbReference type="KEGG" id="mbrn:26242352"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="35504" checksum="8FEBF501766A4FF0" modified="2021-02-10" version="1">MSTRQTRRKSAKLREAAAAAASSDDDQKPIIMNGNGSAHHTPEATDIEEDENIFLFWPNIIGYIRIVLAIASLYYMPVHPRTCSVLYSISCLLDAFDGYAARIFEQSTRFGAVLDMVTDRCTTSCLLVFLSSAFPRWAILFQGLIALDFSSHYMHMYATLVVGGSDSSHKNIDKSQNWLLNLYYTNKNVLFTLCALNELFFIGLYLLAFSSPWLSPHLIKSVEETSGGFINPGAPVNTSLLRQMFPDPFSASALEIARANKMDSLIPWAIAGISLPFMVIKQAINGVQLYNASKWLADVDIKMRKEKGLPRKNKAKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVB8</accession>
    <name>A0A7D5UVB8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SRPK_1</name>
        <name evidence="10" type="ORF">G6M90_00g037260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547087.2">
        <property type="nucleotide sequence ID" value="XM_014691601.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVB8"/>
    <dbReference type="GeneID" id="26239650"/>
    <dbReference type="KEGG" id="mbrn:26239650"/>
    <dbReference type="OrthoDB" id="4936864at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="271" mass="30313" checksum="FAAD41D87A6B37E9" modified="2021-02-10" version="1">MLRADCYGRTHDIFETEILSKICEVSRQSSHEGRAHVSHLLSKSKHKGPNGEHVCLMFDVLGNHLGFQTLLLGLDFLHRECGIIHTDLKPTNILLELESPNNAIAKYLSVVPPRMADPQRGAPLREVITTLPISEIKHPHVRIIDFGVASWRENHLSDLIQSPALRAPEVTIGAPWDTGVDIWSLGCLIVEFIQGIVLFSGEGSILRIPNMKSTSLERLLNGTSKPFLKPEDMLDHEVDILIDFIKGMLTIDPGSRKSAAELLQHEWIHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVG7</accession>
    <name>A0A7D5UVG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TRYP_5</name>
        <name evidence="5" type="ORF">G6M90_00g034160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543343.1">
        <property type="nucleotide sequence ID" value="XM_014687857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVG7"/>
    <dbReference type="GeneID" id="26244144"/>
    <dbReference type="KEGG" id="mbrn:26244144"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="86"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="36669" checksum="78C1D1019B489A3F" modified="2021-02-10" version="1">MERISSSDIKDILSFYSFYSFYSFYHLCHHFYFYSVYTHPTNVHHTLQQPSTQHPHLSIMKLSIVTTILATSGLATATATHHSKRTIGGTNATMDQFPYQVSVQRRVQTFDCQFGVHTCGGIIIARNKILTAAHCTMSDEDDDEFAGSQFQFQVRAGSRDWAHGGQLVSVNNITVHPSYKPGGNQVDDIAVLTLKSNLTLGGKVAVADLAGAEDPMPAAGTEVVVAGWGQTRGGKGPPSRWLRSLRTKVALRWICQFRYLRHGGIGSRTFCAGDWNEFEHTWASDSGGALFDVQTKKVVGIVSYGPESPKSGYPTVFTSIAGYREFLAQVAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVL8</accession>
    <name>A0A7D5UVL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspirochlorine biosynthesis protein N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aclN_0</name>
        <name evidence="2" type="ORF">G6M90_00g051270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539813.1">
        <property type="nucleotide sequence ID" value="XM_014684327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVL8"/>
    <dbReference type="GeneID" id="26247368"/>
    <dbReference type="KEGG" id="mbrn:26247368"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="31518" checksum="51A0FF97F2D9E5AB" modified="2021-02-10" version="1">MAIPSPDQVPRGDVTAALNFYAPPADKAARPFNYVDSPPAGQPQRNYSDHVQDTLIRDVRGRESAFTLDRDAFQIISDVAPSSEPSFADDASIRARYYPEVEALLLAAIPGSRAVHIFDHTLRRADPAAPRTPVTRVHIDQTAASVEKRVRRYFPDEADALLAGRHRIVNVWRPLNARPVESFPLAFASAATLDPADVVPVEHRYPDGYTGETAAVRYSPRQEWYYLSGMTGSERLLLECFDSESLRPGSRVGGRVPHTAFVDPRTRLGAEGRESIEVRALVFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVS4</accession>
    <name>A0A7D5UVS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein vps5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">vps5</name>
        <name evidence="14" type="ORF">G6M90_00g045130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544673.1">
        <property type="nucleotide sequence ID" value="XM_014689187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVS4"/>
    <dbReference type="GeneID" id="26242014"/>
    <dbReference type="KEGG" id="mbrn:26242014"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="149"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="555" mass="62055" checksum="58F336DDD625BC45" modified="2021-02-10" version="1">MDVEESPWADSGDSSQQISQTGPPSSQPAGSQATIAAPRPSRGPRRLVAQPTRLEAVEDPLGPLSALADDNDGTSDAPPVPPQKEQIVIRTTMPQQQQPRRPIDPHNVNDDDFKSPGSPRAPPPVDAARPSSVQSSTQPSVSIEQASKPSFHITVGDPVKIGDLTSSHIVYSVRTKTTSRAYKQPEFEVKRRYRDFLWLYNTLHTNNPGSIVPPPPEKQAVGRFDSNFVEARRAALEKMLNKTAAHPTLQHDADLKLFLESEAFNVDIKHREHKEPIPAESKGVFGSLGISVGRGDKFVEQDDWFHDRKVYLDALENQLKGLLKAMEIMVGQRKMMAEAAGDFSASLHALSTVELSPTLSGPLDALSELQLTIRDVYDRQAQQDVLTFGIIIEEYIRLIGSVKQAFGQRQKGFYAWHSAESELQKKKSTQDKLLRQGKSQQDRLNQVNAEVGEAEKKVHQARLLFEEMGRSLKTEIDRFEKEKVEDFKSGVETFLESAVEAQKELIEKWETFLMQLDAEDDESVFYRPPVYQQQSKPPGDTAIDRARARMDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVV9</accession>
    <name>A0A7D5UVV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiotic coiled-coil protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mcp2</name>
        <name evidence="7" type="ORF">G6M90_00g049250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545034.1">
        <property type="nucleotide sequence ID" value="XM_014689548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVV9"/>
    <dbReference type="GeneID" id="26242375"/>
    <dbReference type="KEGG" id="mbrn:26242375"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="391"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="638"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="771" mass="84944" checksum="3F35E7F3818EB827" modified="2021-02-10" version="1">MVSSESRGSPPQRTGSIPVITFQEEPMSTSGDRPSPVSQAGDNTPFTTGQKNITVLATSKLINQAVPKQSTTEGSSNMSEAYPMDKLLARLSEQQAVLSQQNEALKSGDDEGNMCQRLPGHTSSSNSLPITPATDGFSSTAPSTRPASATLEEARSDSDEVLRLKLQLAQAQNKISKLDQELSIRTIKGESEMQAINAARGMDTTARDSVWMATDDDHSDTSEAMSTTTFTRTKGIWGTTKGSFAGNVLQGAAAEPQPGTWLGGRGFNQSFTDGSSSYQAMEGYRGDRLSPDPDLVMRQSATRRPNRYDHRASNSHHFASVGYNPVNGPMAQFEAIGGPMASANMHPPPGLGAMGMGAYAGYQQQPVGTPLSPHASEFTSKTHWKNEGLPTEGPTYLPPTEPLNYRRLLDRNVTCNWKYIVDKIVCNNDQQASIFLQQKLKVGTPDQKYDIVEAIVAQAYPLMVNRFGNFLVQRCFEHGTPEQVINIARAIRGNTLNLSMDPFGCHVVQKAFDSVPEEYKAIMVHELLRRIPETVIHRYACHVWQKLFELRWTESPPQIMKYVNEALRGMWHEVALGETGSLVVQNIFENCLEEDKRPCIEEVLANIDIVAHGQFGNWCIQHICEHGAPPDRGRAVDHVIRYAAEYSTDQFASKVVEKCLKIGNSEFLGRYLDRVCEGRLDRTRIPLIDIASDQYGNYLVQWILNNATPQHREMVAAHIRKHMVSLRGSKFGSRVGMLCTNHAVTTRPGPGVGPGMGSRMGPGPRFAGAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVX6</accession>
    <name>A0A7D5UVX6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">oli</name>
        <name evidence="19" type="ORF">G6M90_00g044620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986419.1">
        <property type="nucleotide sequence ID" value="XM_066130354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVX6"/>
    <dbReference type="GeneID" id="26240358"/>
    <dbReference type="KEGG" id="mbrn:26240358"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="84"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI67653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="149" mass="15547" checksum="61C1758D22D682A0" modified="2021-02-10" version="1">MASRVFASRLATQMATKAARPAIRAPVAAASKRTITGSASPLQTLKRQQATTLLLATSRNAFQVQRRAYSSEIAQAMVEVSKNLGMGSAAIGLTGAGIGIGLVFAALLNGVARNPALRGQLFSYAILGFAFVEAIGLFDLMVALMAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWE3</accession>
    <name>A0A7D5UWE3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986581.1">
        <property type="nucleotide sequence ID" value="XM_066130346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWE3"/>
    <dbReference type="GeneID" id="26240341"/>
    <dbReference type="KEGG" id="mbrn:26240341"/>
    <dbReference type="OrthoDB" id="5242988at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="851" mass="93726" checksum="35D2AB528870686B" modified="2021-02-10" version="1">MLDRGQQVRRARKAACRSRPPSLQAAPSLAPQGPFEDATGHNVGHGYPPAIDSLYMTPDGLQLSPEDIQWSTDKGVPPTFLSIPPFLHDPQELYDRLHGHDKFDPRWPNRHSLPSKDLRSTVSLDAPSSTGSTLSPVQTEQGEVLIGPRSPSPSHLGREIGKEDADEHARDNTESELANYKKLSRRELSSHIAVEHPGSGQDAVKEWKLPSSAADNRETSPKFHHNTESTPTKSAISVDSETKAAVENVTVARAKKKCQDRLWTIIEKKARKNAGTPRAGHVPTDLVQARTTRTLETASFPLVFEHSILPFLAEFVPKWSGPRHVISCTRGRTAQHRRICIMTTAMLSRTRKIVIARHVADLLPDKYRRLVSFVFSVGQISRAARWARGLSQTHPDDILSARNPYHFSCPCMGDSVGIPGEELIEESTATLGPCLDVDGGSYWLVNFHPFLAAYQNLPMVKIEHPSPQDRGPCLAEGHDCLSDETDFKLGLLTVTSGLNLKTTRISHDPYWGDNEMEQPLVVTDWALVTSSRKSGGRANILRRFPSETQPIIMEPLIRSVCGGTSGISPGAAVVSSGRTSGYQRGTVCEMPAYVSAEENGTGKATREWFVEEPFSSCSSEDSWIRGGIGVEGDSGAAIVDAETNCLYGQLWGRNKYWGPGPRITFFTPAADIFDDIQEKCGLQRRPELPQARDEEDRYAAYPSCRRCYDLKTYQDSRRSSRASLQSMINYRGEAEPDWTPNEHVSELATPQDCHSGGTGIEEIGSSFVNSASPMPPFEFLPDGESAGYYYPTTLVIDETRGIPGEPDFGDVLEATALEQVPKRGSICLDQTPILTSGYDSGSQPKRKRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWQ6</accession>
    <name>A0A7D5UWQ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g063520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986691.1">
        <property type="nucleotide sequence ID" value="XM_066130761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWQ6"/>
    <dbReference type="GeneID" id="26244481"/>
    <dbReference type="KEGG" id="mbrn:26244481"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="31388" checksum="ECE7B49DC7DFEB41" modified="2021-02-10" version="1">MPPVRSTKKNSHLESNAQQLSIESFFTKGVAKDASTSIANPPVISVGASPAAAEAPADSNPPDNSAGATSAAVGALADSNTPPPVKKVANAFQALRPDSKGQVEVYFQSDAEWEKSWQTKLGHRTKKLGFGSSFVLTDRHFEQLISIGTGICRNLTHFEFQYTDVSYGAHNANELTPGTTVRLARMYPCQLAFQLSGPSANKITQASFDALLAHPNWAPKLKTLCIPPPGPDVKREKAWFKSLCAVSKERQMLTIQVTRISEEKKWGDWELTTSATEYRKGKKLRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXK4</accession>
    <name>A0A7D5UXK4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil catabolism protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">URC4</name>
        <name evidence="2" type="ORF">G6M90_00g063350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986763.1">
        <property type="nucleotide sequence ID" value="XM_066130758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXK4"/>
    <dbReference type="GeneID" id="26244497"/>
    <dbReference type="KEGG" id="mbrn:26244497"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="510" mass="55757" checksum="769DD843DAE59381" modified="2021-02-10" version="1">MGFFSRKDKAPKGNSSILASQSTTSVASGNSRGIGNRTSAGSFTSAGTPLSPMSPIKLPKVDLPRPPDPQLDPVGYLRSLGAVRERSKIIMDKATRNELNHFDVDLAKLPNVVTFVSGLIKRDYEAPFNTIPGHGRYQHFCVGDRDRVKELLDSWPESVDSTERCRRLIDLFLVSVLLDAGAGTQWSYKSTENGKIYRRSEGLAVASLEMFKEGLFSGNASNKFQVDKDGLKALTVEKLEAGLQSRPGAELAGLKGRTELLIRLAGALSDKTEYFGADGRPGNMIDHLLSHPSTQASSMLIVPLPVLWNVLMNGLAPIWPPSRTALNGVSLGDAWPCQAMPNPGAASWESILPFHKLTQWLTYSLMQPMQSLLNMHFAGTELLTGLPEYRNGGLFVDVGVLNLKKDDMERGLQNYADYCRRTGHDGVEVAPMFEPSDDVVVEWRGATVGLLDLLCAEVNKHLKNELAGNEMTLPQLLEAGSWKGGREIAEINRPNTKEPPILIDSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYG8</accession>
    <name>A0A7D5UYG8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trans-enoyl reductase FSL5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FSL5</name>
        <name evidence="7" type="ORF">G6M90_00g065210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986842.1">
        <property type="nucleotide sequence ID" value="XM_066130798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYG8"/>
    <dbReference type="GeneID" id="26247062"/>
    <dbReference type="KEGG" id="mbrn:26247062"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF1">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE STHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="363" mass="38385" checksum="EA0384D74732F680" modified="2021-02-10" version="1">MTITHPQTQRAIVGVEGGGLALVENANVPALEEDMVLVKTAAIAVNPVDAKMSAPNLVTAGALAGHDFAGTVAAIGAKTWTAAPIEIGDRVCGAVQGLNPLAPDVGAYAEYVGASDVAVIKVPESMSMEEAASLGTGIGTMGMALFHTLQVPGYPTGPAATPKVVLVYGGSTASGTMAIQLLKLSGLLPIATCSPSNFDLVKSYGAVQCFDYRSENCIDDIKKLTKNALKFVIDCVSEPDTMEFCYKCIGRTGGKLATLEPPPKYLNARERTVTVNWVLGPALHGKPIGWPPPMERDANPELREFAKRWFTTVQELLDQGKLKTHPLKVMDGGLSAVTDGLQMLKKKLISGQKLVYPVVETHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYI9</accession>
    <name>A0A7D5UYI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g060230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544593.1">
        <property type="nucleotide sequence ID" value="XM_014689107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYI9"/>
    <dbReference type="GeneID" id="26243005"/>
    <dbReference type="KEGG" id="mbrn:26243005"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39262" checksum="CC169ADF73AEC352" modified="2021-02-10" version="1">MNETTGRAGIIRARDDASSVDKLVHSVLDDVLYNVISDLVMKTHREEKTAKATTAAIQVEKAASDASDSSSPDSRPDIRVETDSAVYEEGRVLLKGNPLQTIQDILCPKCHLPRLLHPTDGKGAQKPDPAVIYCKKHPYIDKPGCDIYGQSWVAPGPGRGKKKKDVEKKEDGTPEQRPPNVLSFPSATCSKCKRCILVTRLNNHMGSCIGNSGRNASRAAAQKLNGNSQNDSTPPSSQKATPAPGSRAASPRKRDASEENEDSDASHQKKKLKATPNLTKKVIIKTKPTLKKEKSKGSSQLSQEHKLENSSPASTNGKGTPKPAKNGSPVKKIKASKPIQTSPLPKRDIDGMSEISDTMSSPPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYL1</accession>
    <name>A0A7D5UYL1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">met8</name>
        <name evidence="9" type="ORF">G6M90_00g074040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545661.1">
        <property type="nucleotide sequence ID" value="XM_014690175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYL1"/>
    <dbReference type="GeneID" id="26241694"/>
    <dbReference type="KEGG" id="mbrn:26241694"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="257" mass="27941" checksum="838874E9F5CE40B4" modified="2021-02-10" version="1">MARKFPEVQPGGSLILAWQIKDKRVLVVGGGEVAAGRILNCLNADASVTVVCPASGLNAEVAFRVAQKQVTHVDRVFEPSDLEGAEMVLVAIDDPVASTVIWKLCKEKKIPANIADVPPECDFYFGSVHRDGPLQIMVSTNGKGPRLAASIRRFIAGKLPRNAGNAVESIGLLRTKLRKVAPNAEDGPKRMRWMSKVSDTYKWDEMCSLTVEDMDNLLLFYPADKVPSMDILLALRGGNDVRKLDVFDGSFGFSVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYQ2</accession>
    <name>A0A7D5UYQ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986966.1">
        <property type="nucleotide sequence ID" value="XM_066131158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYQ2"/>
    <dbReference type="GeneID" id="90968042"/>
    <dbReference type="KEGG" id="mbrn:90968042"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028857737" evidence="1">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="107" mass="11743" checksum="0AA094A6794F4499" modified="2021-02-10" version="1">MKTFTLFTLVVGIVTAMSRDEMLCVDKLEDRTENPAGRNVFDLSGHMLSTVQDLQKAVAYISDEGKKAQLERIGDELFYLGSQINGIAGGDMLMYSKPMGTCLNSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ23</accession>
    <name>A0A7D5UZ23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g073440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545721.1">
        <property type="nucleotide sequence ID" value="XM_014690235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ23"/>
    <dbReference type="GeneID" id="26241754"/>
    <dbReference type="KEGG" id="mbrn:26241754"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="269" mass="29505" checksum="F382E939ED993F58" modified="2021-02-10" version="1">MSRGGRGGGRGGRGGARGGGRPNVPWDTGDEPDARPSELFPPYTVPAPRDLASAEASAVQHFLLLRHQIHSSPLYTSKRTSLHDPTTPRKMYGQAQMNARYGVKNKASVDPFTAMPTYSQKFVREERALPDWAARPVCREMFPAELLDTVEPEDGVGVRKKRRLELSKVSALPNAEEAFGMPSLDGAVDEEAEAVRGTGKNILEKLDAMREDEGDEGIDAEDDEGLEEDDEDEVYDDEDAGDYDAEHYFDNGDEMGDDYGEGDDGEGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ34</accession>
    <name>A0A7D5UZ34_9HYPO</name>
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        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g074720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545595.1">
        <property type="nucleotide sequence ID" value="XM_014690109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ34"/>
    <dbReference type="GeneID" id="26241628"/>
    <dbReference type="KEGG" id="mbrn:26241628"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16106" checksum="F1120FABE540CD66" modified="2021-02-10" version="1">MSPSTKRRAADDSDEDQKVSVKSSKKTKHNVTADGEDDDGNPFWELSNKRRVGVSQFKSVCLINVREYYEKDGKMLPGKKGISLSVAQYTALLKAAPGINAALRQMGQAMEDVDDLGDATVEPTKKPKKEKKNASKANIDATSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ74</accession>
    <name>A0A7D5UZ74_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dapA_1</name>
        <name evidence="5" type="ORF">G6M90_00g080630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539341.1">
        <property type="nucleotide sequence ID" value="XM_014683855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ74"/>
    <dbReference type="GeneID" id="26247884"/>
    <dbReference type="KEGG" id="mbrn:26247884"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="32716" checksum="7F94EA8FBCE1BF8B" modified="2021-02-10" version="1">MGNTRNIFQGLSAFAITPADPDGKVDTAALGRILERLDMPGIDSIGLLGSTGTYIYLTREQRKVAIDVAIRTLRGRKPIIVSAGALRTDDAQHLAKDAEEAGVDGLLLAPVSYNPLTEEEVYRHYESVAGSTTLPICIYNTPSTTHFTFSDALLARIAGLPNVVALKQPAPINEPKGRHEALRANLPSGFSVGYSADWLVADSLMAGGSVWYSVIAGVLPAPSVALMDAIRRGDDAEVKRISALLEPIWELFKEFGDLRVVYALANELGLCKAAPPRPILPIAASHHRRIVSALANVNESMKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZV7</accession>
    <name>A0A7D5UZV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545376.1">
        <property type="nucleotide sequence ID" value="XM_014689890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZV7"/>
    <dbReference type="GeneID" id="26241409"/>
    <dbReference type="KEGG" id="mbrn:26241409"/>
    <dbReference type="OrthoDB" id="4932434at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029001504" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="11945" checksum="127D8AC249B2E52B" modified="2021-02-10" version="1">MKVRNLAPLAAAIAPSLACLHSAGSVLFPSSGPVLQTAYIVDDGRSVCDSGRGHWVEGSQWRISCIGGYGMRIATDGVDVWYDTPHGSFRWQHTGGRSDSAFAWDNWKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZW2</accession>
    <name>A0A7D5UZW2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GDP-mannose-dependent alpha-mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mgtA</name>
        <name evidence="6" type="ORF">G6M90_00g074140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050194">
        <property type="entry name" value="Glycosyltransferase_grp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45947:SF3">
        <property type="entry name" value="SULFOQUINOVOSYL TRANSFERASE SQD2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13579">
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            <end position="504"/>
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            <end position="225"/>
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            <end position="410"/>
        </location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="526" mass="58392" checksum="F4375F0ED3472050" modified="2021-02-10" version="1">MSSAKFAGGSSPYKEHDLSQFPTFLKGKRILLCTESFGPVNGVSRTTLMLVNHLRNNGAQVAVVAPHNHTNHNTFSPPPSPNLSPADRQPEVRVTGYPLPFNPELSIVYPVRNSSLYSRTFGDDSSPDLIYLASPASLGFQVMLQLRQQPREKQIPIICNFQTDLAGYCAILFPSPLSHIAVFAFDAVQSYLFRHSSVKTIFYPSRFVRRYLVHNKVQPEKLQLLTRGVNTEMFDPKRRSEDLRKKLAPNGEIIFVTVSRIAGEKGFDFLSKAAKELDARGLDFKLYIIGGNRNPDVEKEVQELFDPLREQGKVVFAGFKVGEDLATAYASGDIFLHCSITETFGLVVLESMASGVPVIARDEGGPSDIVQHGDTGFLIPPNDMDAFVTKAVKLANDHILRKRMGVAAREAACQATWDKINNKVAWGMADTISERIRECEKVRRLSEHAALSSTAQQLVPIYGWLMMNNALREAMTRSIIDARLMGGLGIIITFWAVTGCYVLFTECLMWAKGRMRAGDSKVSVTI</sequence>
</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI71250.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
    <sequence length="106" mass="12102" checksum="428A3A0A87058C09" modified="2021-02-10" version="1">MVNIPKTRNTYCKGKECRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECVKCKTKCQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
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    <accession>A0A7D5V0C9</accession>
    <name>A0A7D5V0C9_9HYPO</name>
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        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
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    </protein>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
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    </reference>
    <dbReference type="EMBL" id="CP058935">
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26194" checksum="C8DD2D9F322EECA6" modified="2021-02-10" version="1">MKVIVTGPTGRAGQEVVKKCLEDERITKVVILTRRGLPGEIESHPKADVIMHQDFTQYSDYLIRRMQGSEACIWAIGARQEQAKTDKFIERRVGVDLPIASAKILCEKLADKTPGGVKFRFVYCSPKHTEKSKKTLMFANDKRKLANDLEKGIAEIVNSYKGKFEAYTLRPANFRMPDTPPPTLAPSSKKLVPGLGQSAAASIDPEKVGKAMVMIACDGWKEKVIENETILKNWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0E1</accession>
    <name>A0A7D5V0E1_9HYPO</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="3946700at2759"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="485" mass="53119" checksum="EEC0B82AD097BB3F" modified="2021-02-10" version="1">MGLPLFVEPVESDLPNKTSIKTGATSPPRSSSRRPSRSEIRDRRSGIRRAGVRIYNSAQRNVPRNARERLLPWVESSSSRTQDPTDAAAADRRSGIFREVLREMSGSDERRRERLEERMSALFNSTSGSAPPEHENMSEGVDLGWWSAGDGSRLAHVRRSRVHAPQSQTNRIADGPLLLPPRRAHPRQQQDITATRSGDLSPLDPYLLRSLNARQMMPSRRGALGMDGLGDRERSLSPEGWDTLLSTLTPDPQPPSAGSSFASVAASQTAGPSSGTPTSAPDIMEEALLDAPCESGCENSDLDMDDADYEHPDFARIRRTRQDRRNLELVRANRLALTSGDPRMETTGHPTPGSRTTRQINTANGPLTIYESSGRLGQAIEPTRLSRPSTNNSPGVWVGQLSVGALGQEDGDADGPSQNPEDATFPTQSNAMASEDDWAGMQRIVRSLARREDIPDEWWADAGLSRTLRQEESSTTSNGTMRQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0F6</accession>
    <name>A0A7D5V0F6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase SEN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SEN1</name>
        <name evidence="14" type="ORF">G6M90_00g090680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987288.1">
        <property type="nucleotide sequence ID" value="XM_066131381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245589"/>
    <dbReference type="KEGG" id="mbrn:26245589"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="10">
        <location>
            <begin position="88"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="13">
        <location>
            <begin position="1172"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="1321"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="12">
        <location>
            <begin position="1622"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="915"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1884"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1990"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1460"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1902"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2025"/>
            <end position="2035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2047" mass="229746" checksum="600E989306428E27" modified="2021-02-10" version="1">MSDLNEELAKWYEELQKLPHDCHLLCPKIDSDDRENYKTFDDPESQITVEDKKQRIEDGHHRIEITYWNSLIFGFDKSEAGKWAEEFKDRLEHVLRSCSECVLNWHMQRQVYLQRFSEKWNEQVIEHIEQMLNRIDIARISCNLQWAKEYIGKIEERGDVFKKTQLGEKLPEVLIAVYEALCCMPFMSTPDQRALFQYVFMRLQGKSYLKLGRSDPLPGMTYFLFDQKNDDRRKWAQENWKFINSKSMTEAQFDWAVSNGLTSAIDDIARIQVTPQFSDEERLAIERFWEGFEIILTKLPENLIHSRLRSLELRQGSSIYDLLFRHIQTCPSEGMLVVTIRVLTIFLKDYPKAFWDVIGDARPNVIADLLFASPVYKVLLRQSLDDCWSGFSMDSDVVPFPTSWIQPWLMSLGRDRRYDACEVLMHTLFATLAKDPFIGEPGQAACIRAGFDAINFTLKSFLDPDIQTASGTTHLYAGGAFNLVVKNKDLILESLRPPQDSREGWTTFRVSDAAMSVLHAAMKLDMKMFLEEFQAIHNKKQLQSTILRESKTFWETIVETFDSSGDQVTLAKDVLVSLGPLISVEQIRPRKSINKLDESSQRFNTSLGSIADVLARILGRVSEVDATDLNLLFADRLSFQVIVGLSVHDDSNLAEGSAEILKSWTGELSRSGAIEHMSQLHPEQTLSSIVWTLERVLKPPFPWGPIRPLLNMSRDVLRGLSDPTSGVLRTKTLNSKSVAVVLRWWNEQWRFVSKSCLNIESWSFCISNAIMTEFCREIMELAEALIAEDGLLTSATALGKSEQDVMPIILGPAKENFRGMENMIRLKDRWLVDVTVRVLGKILTRLRENKLEINAGSRKLITDACIPTGTTGKYLRSTNLTDQQRAELLQALGHDEEVQILQLGPTTSVVDRTTALDKERSKKQSKLDAWSKSAPPGTPSDKVGRSNRDDVLEFSRSADSPILKQLAAQQARSKSKGPDMKAILALKESRQRERAEKAKRDAEAIARAKKIRGELVPGEGSGAQSLASTGKDNARSEIMVNSSDEESDDDSADSDSDEQLATLSTGGQKGLDEHEKRRQQALRDRLRRPVKKIRQQRSVKEMRARLIPPMDRLHNTILAWDIFHQGNDPPNGPAASEVATKYPDPRSYQATFFPLLASEAWRSFVTAKDEITAQPFGMKLASRASVDSFLEVAFTLPVVQNRERGVSEGDILLVSEAESPLQNPISRHCLARVHRITYKKDLIEITYRVASRNNQLSTLLMPGVTIYGVKITNMTTIEREYAALESLQYYDLMDEILKAEPSPILRYGEEKISNAMQNWTLNHGQAVAVLGAQDNDGFTLIQGPPGTGKTKTITAMVGSLLSEQLAQASNGVPMGAPLRPLAGAIPAGQGRPKKLLVCAPSNAAVDELVLRLKSGVKTSSGKTKPINVLRLGRSDAINAAVKDVTLDELVRNRMEGDNTKDKAKAERDKLHGDAAKIREELAEIRQLLDEARAQDNRITQNTLSRKFDELKRQQMNIGKQIDANKDSGNSLAREMEMRRRQVQQEILNSAHVLCATLSGSGHEMFRNLDVEFETVIIDEAAQCVELSALIPLKYGCCKCILVGDPKQLPPTVLSQSAARFGYDQSLFVRMQQNHPKSVHLLDMQYRMHPEISMFPSKEFYEGQLQDGQDMLQLRHQPWHQSALLGPYRFFDVEGVQEKGRKGQSLVNTRELQVAMEMYDRFSKEYKQCDLTGKIGIITPYKAQLFELRNRFTSRYGENITDIIEFNTTDAFQGRECEIIIFSCVRASSTGGIGFMTDIRRMNVGLTRAKSSLWILGDSRALVQGEFWKKLIEDAKARDRYTKGDILGMFRRPLRRASPSSYQAPQKESPKDIEMLDSPAAKPIMDGVKNIKSGPSTDLPALSNGSQSRKTTDGSIPNVVPRGAGLPVIHTSDNQASEPKKRPLDGSEPGQQAAKRVCGISVAVQTTSNQAQISNTTADCEYAARRPDGQIRTKTCQTDDAAAAQGSVGNVSPRDGTPGTTPSSSDEFESDSDESGTEWVDVDIGSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V173</accession>
    <name>A0A7D5V173_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g085470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541104.2">
        <property type="nucleotide sequence ID" value="XM_014685618.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V173"/>
    <dbReference type="GeneID" id="26246093"/>
    <dbReference type="KEGG" id="mbrn:26246093"/>
    <dbReference type="OrthoDB" id="4956736at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11304" checksum="0301FA371697A271" modified="2021-02-10" version="1">MAPPTTITGTATESLSQTSIVTMDTRADEEAEMEVEVEVDSLGRGPNQLKVPVVPRAPEAHCRSYMAAVFCNRARVGFTEGISGHISVRDPEHHGLILRRAKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1A1</accession>
    <name>A0A7D5V1A1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g081530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987270.1">
        <property type="nucleotide sequence ID" value="XM_066131180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1A1"/>
    <dbReference type="GeneID" id="90968050"/>
    <dbReference type="KEGG" id="mbrn:90968050"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="89" mass="10125" checksum="A70D867C073F8222" modified="2021-02-10" version="1">MLEIVCRFILDALTLNNTDASTETRAKKDGNSSHISKHKAIKLCKNVLTNTLIGSTQHRLENKQALDTLGQELKEFLAISLWAQWLDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1R7</accession>
    <name>A0A7D5V1R7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g089760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541636.1">
        <property type="nucleotide sequence ID" value="XM_014686150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1R7"/>
    <dbReference type="GeneID" id="26245499"/>
    <dbReference type="KEGG" id="mbrn:26245499"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="179" mass="19748" checksum="0D24A08D569CA42A" modified="2021-02-10" version="1">MSDVKDISPDLDRLDRQLDNLEDALAPLLNNLNEKASQLPLLDKAKLFSLTAYSIESLLFSYLRLQGLDAQNHAVYAELKRVQQYFGKIKAAEEPETQRSLVVNQEAAARILKADLADNKSISSKLAEKIAEERAKALLKSVESRKRPADESAASGGSGSDAQVNKKRKQKGRGKGKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1U9</accession>
    <name>A0A7D5V1U9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Laccase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Conidial pigment biosynthesis oxidase Mlac1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">abr2_1</name>
        <name evidence="18" type="ORF">G6M90_00g093480</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Laccase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress. The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA. The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pigment biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987582.1">
        <property type="nucleotide sequence ID" value="XM_066131447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1U9"/>
    <dbReference type="GeneID" id="26247778"/>
    <dbReference type="KEGG" id="mbrn:26247778"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028849501" description="Laccase 1" evidence="14">
        <location>
            <begin position="30"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="124"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="358"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="534"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI72976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="687" mass="75860" checksum="0BF81D582A43C974" modified="2021-02-10" version="1">MSLKIEMNYSRFAFLSVVLLLYQSSLSFAASRSYNFTIHSETRAPDGVSRQVYLINGQQPGPLIDVDEGDSLEIFVQNNLPVDTTIHWHGILQRASPQMDGVPGVTQVGHYFYLPTWNLVDHWQYPIPAGGNFTYRFNLQDEYGFFWYHSHLRAYYNDAIRGPLLVRPSPSRGRPFEQLASTEGEKTLLMNAERDAPSILLNDWTHEPSDVIWSRYFTTGAFPNCVDSILANGNGRVQCLPEFQNGMMPKANQTSLLTSSMAMIMSGMNKRMNMDGSSMDMGTTTMVMEGPTRTTVPDTATTASTTMMMASLGPRGCAMPMMFNPGYNASSLPPETCTNTTSSLLNISANSTTGWLALNLVNSGAVSALRVSLDGHSMFVYAADGSFVQLHEVKVLHMALGERYSVMIRLNQMPGNYYLRFATYPVGDMQQVMEGQAIISYNISQTTSNISTDVMEDSSIVWMLKNGSAKSEASLLNPSKLAPFESNSPPSKAADRTQLFAINQTGVTAWVMNKAPFTEPRVPILYGAQSEGWLANTTIRMPSNSVIDIVMNVANESLDTMGHPMHLHGHKFWVLGTGTGTFPYATAQEAPKSLINLQNPPYRDTVELPSSGWAVIRYITDNPGAWLMHCHLQWHIVSGMAVVLIEGEEKLPGLLGSKAPPTKSTAVSFRSGYKHIAWATVAMFLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V232</accession>
    <name>A0A7D5V232_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein FYV10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FYV10</name>
        <name evidence="11" type="ORF">G6M90_00g086220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541180.1">
        <property type="nucleotide sequence ID" value="XM_014685694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V232"/>
    <dbReference type="GeneID" id="26246169"/>
    <dbReference type="KEGG" id="mbrn:26246169"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="8">
        <location>
            <begin position="329"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI72437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="45679" checksum="CFADEC5E056D8D80" modified="2021-02-10" version="1">MADYEQSTLKHNEHLLLDQPLLRLPHELLRKNFRSAHFTIEKDTSTLKTLLKDSATAAVSGRASQQDVLRNIDTMITRMRGVKRKLTTYADEEARIHHQTAARITHLDELYSIRSVDDVKYEAWSRRRLDRLLADYLLRHGFNQSASELAEEKDMQDLVDVDTFVNMSRIREALLGGSVTEALAWCTDNKKELRKMESKLEFMLRLQQYVELIRTQSEPKLVEAITHAKKYLIPYWKTYPKEVSQACGLLAFPPGGHSSSAYSNFYKPSRWSELADLFTKAHNNLLALPSVPLLHVALSSGLSALKTPACHSSASHQGEGTSTLGHGVCPICSTELNELARNVPYAHHTKSHVEHDLMLLPNGRVYGSQRLQDQAKKAGLPPTLVKDIQTGEVFAAEGLKKVYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V282</accession>
    <name>A0A7D5V282_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Psma3</name>
        <name evidence="6" type="ORF">G6M90_00g101050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987581.1">
        <property type="nucleotide sequence ID" value="XM_066131584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V282"/>
    <dbReference type="GeneID" id="26240663"/>
    <dbReference type="KEGG" id="mbrn:26240663"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="292" mass="31670" checksum="9FE2A352ED21603D" modified="2021-02-10" version="1">MTSIGTGYDLLNSIFSPDGRNFQVEYAVKAVENGGTSIGIRCKDGVVLAVEKVVTSKLLKPGANKRIATVDSHVGVVYSGMVPDGRHFVDRARDESQSWRQNFKTPIPTADLASRMGGYLQAYTMYGSVRPFGITAIVGGVDTSEETPVDGEVGSGPKCGAGGKVAGKHGGPFLYMIEPSGLYWGYYGAATGKGRQAAKAELEKLDLQSGNMTMEEAVKEAARIIYIAQKDNKDKDFELEMTWISGVDGPTKGRHVEVPKELREEAERLAKAEDDSDDDDENDKKDDDKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2S2</accession>
    <name>A0A7D5V2S2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">E3 ubiquitin ligase complex SCF subunit scon-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scon-3_1</name>
        <name evidence="2" type="ORF">G6M90_00g095020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987607.1">
        <property type="nucleotide sequence ID" value="XM_066131491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2S2"/>
    <dbReference type="GeneID" id="90968151"/>
    <dbReference type="KEGG" id="mbrn:90968151"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component dimerisation" evidence="1">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="128" mass="15449" checksum="BFAA27B1493EEB4D" modified="2021-02-10" version="1">MNSRLKAPSILRKVFQWCKRHRDTRTTTRRMWDQKYMQVNRAHVMEITQAAWYLGIDRLWRLGCKIVALEMRDKSAEEKIREYLNATNNFTLELKAEICLQYVWPTDGRDSVMKMLTWAFNQPSLFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3H4</accession>
    <name>A0A7D5V3H4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g102090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546137.1">
        <property type="nucleotide sequence ID" value="XM_014690651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3H4"/>
    <dbReference type="GeneID" id="26240560"/>
    <dbReference type="KEGG" id="mbrn:26240560"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="268"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="404"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59305" checksum="91E0940B5CEE8C5D" modified="2021-02-10" version="1">MSMITAAQWVPRGFAAPFPKKYTLDESEFARIAELAKLQLDDAEEDLKEAQEEEGSDGQNQKAGNDESMDVEGEKPTTEAKYDDDDLKEYDLEHYDDDEDEPEAHEDGTGMSMFGNLKALAYHGSNKDDPYITLKDEDDDDEEKEDLQILATDNLILSAKVEDELAHLEVYVFEDEGDNLYVHHDIMLPAIPLALEWLDMPVNNSGGDQGGKGNYVAVGTMDPDIEIWDLDTIDCMYPNAILGQAASAESGEKKIKKGKKSKKAKANDAYHVDAVLSLAANRQHRNLLASASADKTVKLWDLNTTQCAKSYSYHTDKVCSLAWHNTEATVLLSGSYDRTIVAADMRAPDAKAPRWGVESDVENVRWDPHDSNYFFVSTENGCIHYHDVRNAPSNPTATKSVWTLQAHDESVSSFDINSVIPGFMATGSTDRTVKLWSIQPTGPSMVVSRNLDVGKVFATTFAPDAQVGFRLAVAGSNGNMQVWDTSTNAAVRKVFAQKVPAQKDDVAEDRLVGVEEDESSSSEEDGEGQEDGESMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4A2</accession>
    <name>A0A7D5V4A2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540347.1">
        <property type="nucleotide sequence ID" value="XM_014684861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4A2"/>
    <dbReference type="GeneID" id="26246941"/>
    <dbReference type="KEGG" id="mbrn:26246941"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="83943" checksum="4886C2CB272621BE" modified="2021-02-10" version="1">MDEIEELRRLLREEQRRREEVEELAKASLPLDLQQYLGACHSLDLAIDVVTDRSLTTQGETTNPTGRIFPRRIIPWDSFAMRQEEIWNDLSISDLLPKPSFPSYHQMEYVKSLLKPISSELGLRDFERDVVENAVQKLVDRAHTDPSLQNSLGLQGTVTFESHTNLGTTDDAISAPMEHMSLGRDGADAAVQVPAPKPPPAPKARRRARGKGNRADQFCIYRTSDGQNCPAVAIEYKAPHKLSLDEITTGLGAEIQPERDVINKTDHGFAFTARRLAAAVITQLFSYMIGKGIQYGYVCTGQAFIFLHIPDDPTKVYFSVCVPNLDVMDDDETRLHRTAVAQVFAFILQSLRARPPPETWHDEAETLGIWAVEYDDILRDIPPSERKRKEPRASPYKPQRWKGFQRSPIRTRSSCQQPNTSAGRLEDDDEDPPSPTPNPSRRGEKAFSSVDTSLSNRNQGRRRGQQKVSDPGKKPDIQSRPFCTQRCLLGLAYGGPMDKNCPNAGYHGQKRISRLEFLQLIRHQLAVDRGRDADCVPLHRSGSRGSLFKVRLTSHGYTLVAKGVEGLDLACLQHENDIYDRLQPIQGKYVPVCLGTIGLVRPYYYDSGVYMHFMFLSWAGQPIFDCVDRAMKAGIGSAVSMAFKAIHNLRVLHHDAEPRNILYNTTRRGLMVVDFERAEFHGRQPLASIGPNENRKRKRRISQKLKKDDFVRELEYAVARVSSCIANLPSPAALIVDETLHDVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4C5</accession>
    <name>A0A7D5V4C5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-1,3-glucan-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BGBP_1</name>
        <name evidence="5" type="ORF">G6M90_00g107990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987940.1">
        <property type="nucleotide sequence ID" value="XM_066131738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4C5"/>
    <dbReference type="GeneID" id="26243432"/>
    <dbReference type="KEGG" id="mbrn:26243432"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="171"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="448" mass="50323" checksum="307D6B816664EC37" modified="2021-02-10" version="1">MSNVDNMSETPPDEGPSAAPRRAVKVVINSDFAATSSALDVPARPSSVIPRDFSSLDIASRRRFKSYRLRGEFEKPWLADPAMNKTKWNNWIVRGFILLGLILAGVACVFLVWPYKDGPYCLVYEDHFTSLNKDIWSHEVQLDGFGTGSFDWTTSDAKNSYVDAEGLHIVPTLTNESTPITNNDLFANYTLDLTKDGSCTSTANTSCITTSDPKKGAMIPPIRSARLSTKGKKSIRYGRVEVVAKLPRGDWIWPAIWMMPEASTYGEWPRSGEIDIMESRGNSRAYTEGGRNYYYGTLHWGPTAEKDSYWRTTNAKMLRRGDFSRGFHTFGVQWTPGYIYFYVDSRAHQILFVGFDRARPLYDLGRFASMAENQTLLANPVAVGSKNGWFLDHVGDKPWIDGAKNAQWTFWDAAAKWLPTWGEGTERGMTVRSVKMWQAGQCGSPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V510</accession>
    <name>A0A7D5V510_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LIP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g093990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540763.1">
        <property type="nucleotide sequence ID" value="XM_014685277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V510"/>
    <dbReference type="GeneID" id="26246376"/>
    <dbReference type="KEGG" id="mbrn:26246376"/>
    <dbReference type="OrthoDB" id="2373480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005152">
        <property type="entry name" value="Lipase_secreted"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34853:SF5">
        <property type="entry name" value="LIP-DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03583">
        <property type="entry name" value="LIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028972817" description="LIP-domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29324" checksum="541A8D84ED6C4F8D" modified="2021-02-10" version="1">MQFMFPLLTLAALALPPASAHPMSENKPRALPPSIDPFYRPPSGFESKAPGSILRQRRIAAAFFGFIPQPIEAYQLLYCTNAIDGSPIAAVTTIFKPLHAKKDSFVSLQTAYDSTASICNPSYTYQLGALQTNIISSLEQIIMQAYLLSGYMVAAADYEGPDAAFLPGHLEGMGVLDGMRAVVNFRTKLGLSDNPKIVGTGYSGGAVATGWAAGLQSSYAPDLNVKGWVAGGTPANLTATFMNLDGTIFSGFLPAGLAGFLKPSAYGAQLQPVFDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5U9</accession>
    <name>A0A7D5V5U9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA delta isomerase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Eci2</name>
        <name evidence="1" type="ORF">G6M90_00g111360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543728.1">
        <property type="nucleotide sequence ID" value="XM_014688242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5U9"/>
    <dbReference type="GeneID" id="26243115"/>
    <dbReference type="KEGG" id="mbrn:26243115"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF3">
        <property type="entry name" value="PEROXISOMAL D3,D2-ENOYL-COA ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="30155" checksum="4FCBBE8BAC1024BC" modified="2021-02-10" version="1">MSTKQYNDIIVEITGQVGTIKLNRPHALNSFGGKLLQETIDAVRDLNEHPDTVFTVLTGQGRYFSAGADIRGGTLVNFGPFANNTEAKLAFSTQLFPGVELVRSIIEHQKVLVVALNGPAVGGGAAWFLGLADIIFAVESSFLQVPFSALGLVPENGSIRNFAQSMGVHRANDFLMFGRKLTAQELEQWGLVNRILPAAGFHEGVEAFLQEQLRVNDGRSMMLAKQLQNAPLRAERLLALYDAADALAERFVDGTPLRRLAMKGAELEAKSKKPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5Z9</accession>
    <name>A0A7D5V5Z9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nudix hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NUDT1</name>
        <name evidence="4" type="ORF">G6M90_00g110350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543824.1">
        <property type="nucleotide sequence ID" value="XM_014688338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5Z9"/>
    <dbReference type="GeneID" id="26243211"/>
    <dbReference type="KEGG" id="mbrn:26243211"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="167" mass="18818" checksum="762BE123146B5FC8" modified="2021-02-10" version="1">MATSAPNVRAGVAVFVLASKNEDQENPRFLVGRRKGSHGAGTMALPGGHLEFGEETEECATRELLEETGLRVADIRFLTATNDYMPDDNKHYITLFHVCVRENDSNEPQLLEPDKCESWEWIAWKDLLGWIQTSRNTSAEDDSLKHKVFLPLINLVKQRPGVRPTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V616</accession>
    <name>A0A7D5V616_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g112230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987954.1">
        <property type="nucleotide sequence ID" value="XM_066131854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V616"/>
    <dbReference type="GeneID" id="90968270"/>
    <dbReference type="KEGG" id="mbrn:90968270"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7432" checksum="3622588F4879F0DF" modified="2021-02-10" version="1">MAPFPPRSRCVSPLRRARTREVDGLPLRRFGSGVARALRRRGADGDDAVAAAVSMCVEQLYRFEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V739</accession>
    <name>A0A7D5V739_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g112100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540282.1">
        <property type="nucleotide sequence ID" value="XM_014684796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V739"/>
    <dbReference type="GeneID" id="26246876"/>
    <dbReference type="KEGG" id="mbrn:26246876"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="226" mass="26426" checksum="CDCA1A4F8EAFCB94" modified="2021-02-10" version="1">MELFALDSLFKDIPKRINFQNLNEKYVLAHPDLRCGNIIVTSDLHILGIIDWEFTSAIPLQLFTPPSWIMGHDPSTLRIITGIHRGNIFPEFCGVLKDMCHTSIACTQLWHDWGLEDERPQQDYTYDIKQVSPLMQILRQPGSLIEVYYSSIFPKLFGPEACKDTVRSEFFADDKNRELLEQVEVQMKNSERYTDHLRKHNLLVEDERIQLIQEFLEKTKFLVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN15</accession>
    <name>A0A7D5YN15_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic cell wall galactomannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g005140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542161.1">
        <property type="nucleotide sequence ID" value="XM_014686675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN15"/>
    <dbReference type="GeneID" id="26245192"/>
    <dbReference type="KEGG" id="mbrn:26245192"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF4">
        <property type="entry name" value="CELL WALL GALACTOMANNOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028828398" description="Antigenic cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18114" checksum="143381FBC2254F08" modified="2021-02-10" version="1">MRLTPILSIMALAATAIADGKAITDAMASIKTKTTDLGATVSNWKGDLLGALPITVKSTQLLKEIKTATKTASKSAVLTTEEALAVAGATTDLSKAVTASLQIIVDTKPKFDRLIILSPVVLLNLEMLKDATDDFSSEVVSKVPEALQGIAQSLIKPIEDAFAAAIKKYQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN91</accession>
    <name>A0A7D5YN91_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear distribution protein nudE 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NDE1</name>
        <name evidence="10" type="ORF">G6M90_00g016380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548890.1">
        <property type="nucleotide sequence ID" value="XM_014693404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN91"/>
    <dbReference type="GeneID" id="26238334"/>
    <dbReference type="KEGG" id="mbrn:26238334"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="9">
        <location>
            <begin position="131"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="589" mass="63912" checksum="E0A96312EF094F1F" modified="2021-02-10" version="1">MAEPPSSPPSEAATAEDALTWYKSQYEMLESELAEFRESSRELEQELEKDIERAEKQERALQEKVETLGFEVEEWKRKYKESKSEASAAQNSLEKEITTLRDSNRSLQLKLRDVEVANDDFERQARNTTSSLEDMESKYNQAIERGVMMEEEIKSGEQERENLRIESQRLREELAELKIEAELMQDKIKKHEARHLSTISTDLSVMGSPTFDKNTEGSPNSTASSPLITTPPETKSLPAVESLSQVHEPPSPPMSDASAPTANGTPAAKAGGTLPRKSRLPSLDHSATPKPRGKPAVARQGGRISGGPSSLRTPAPRSTTVPGSSKHKIPASNSLSHIRSLTAQMQRLEARVHSARSKLPAPTQTPPRASPRPMANGSSVPSTVTIRSRKRTTGSCASSLAGDETTPTNFRSSTSSRPSHVPRLSTTGVSRLSFGPLPNRGPESDASHSRPNSRASVSSYARPSSRTDMIPPPRPMSRSSLTGARTPLGRPRSSLSGSVHGHSQSMSRIEMEEDYEGEFRTPSRRGTYSKVEMEGAVSGIPVPGTSIPTPGTRRQSGSGPGGRRTSTGVGTARPGTSSSRRLSDLGETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPC4</accession>
    <name>A0A7D5YPC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g033180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543247.1">
        <property type="nucleotide sequence ID" value="XM_014687761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPC4"/>
    <dbReference type="GeneID" id="26244048"/>
    <dbReference type="KEGG" id="mbrn:26244048"/>
    <dbReference type="OrthoDB" id="409848at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360:SF1">
        <property type="entry name" value="F12P19.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38360">
        <property type="entry name" value="OS03G0120000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028926649" description="Periplasmic binding protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="56575" checksum="B08197903133B8E5" modified="2021-02-10" version="1">MKGFTQLALLAASATLGQAAFREGCADAPWDSDTDFFLTKFEKSPTNPFLAEYNKTYVTIKNRQSRYVVLYCSKEPPPTSIVGESSLFVKAPVKNVAALDGFSQNLIEMLGMSTSIKRTGVYSDVTSSCIRGNMKDNITFDDDEWDKAPKVDVTFYGDTATSDNKKVLIYNVGNYAPLAQLGYIKFVSMFFGLEELGEKLYDEISANYRCAAAQVQQAVMAGTYPTGALISPIRKDGDKFTVFQSAWWNSILSDAGSALVNVSADGQAAETGNPTKPALVTIDANSAGNNFARNSWAIIDTTQYDQLPGKQAPKTLPESTRITADTYTSRSGASSASYAVKNNNVWLTDKAANRNRRHNFFDRGSARPDQVIRDIISVVSPSFLPDYSNMFIRSVSKPDDEIALRRFTNTCAEKGKELETLSLTKCDAPAWVAGYHDSGLKPNAYRSADQAESLALRASGSGLSGGQKAGIAVGSVVGFLLLAAAAGFGIYKCRRARAGDKNAKRSEMDQVEKGSVSSRSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPL0</accession>
    <name>A0A7D5YPL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g014490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549073.1">
        <property type="nucleotide sequence ID" value="XM_014693587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPL0"/>
    <dbReference type="GeneID" id="26238517"/>
    <dbReference type="KEGG" id="mbrn:26238517"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="255"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="379" mass="41732" checksum="4BDA30E3D3181C7D" modified="2021-02-10" version="1">MGAARRALPTRLLCRSCLKHQQRRFASSAAPPKPPPSGLAALPSRQLLSVSGPEATKFLQGIITANMANAEGLPRRDAFYSGFLNATGRVVHDIFIYPFRQAKQDDGYLIEADAGEMARFAKLIKRYKLRAKVTVRNVPPDEASVWQAWDDASPLDIAASESRVVLKDPRAPGLGHRIVQLNHKAPELDVDASTEDAYTIRRYLQGVAEGQDEILREQALPLESNMELMNGIDFHKGCYVGQELTIRTRHRGVVRKRILPCAIYSEDKAPPQTLSYDPECASPESLTADMIPAETSIGRFGKKGRSAGKWLKGVGNIGLGLCRLEIMTDVVLPGEQAAATYKPGNEFVLEWGDEDNKSDVKVKAFVPKWLREGLSAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPT1</accession>
    <name>A0A7D5YPT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g020190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548526.1">
        <property type="nucleotide sequence ID" value="XM_014693040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPT1"/>
    <dbReference type="GeneID" id="26237970"/>
    <dbReference type="KEGG" id="mbrn:26237970"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="58033" checksum="1CCB2C306C0CB27A" modified="2021-02-10" version="1">MADPALHDCPMQKIPVEVLLRITYHLGTPDLGSVRLTCRSMEQALYTPFVIEFFTRKQFMIAEDSLQALIDISKSRLAHHLRFVHIGLDRFSEGIQRPLPDDDKERKFRERYANNFTLWNTGHHRDMMAEAFRNLPYLEGVVIRDANSHRRSRDGPNAEWHSYGYTTAFHDTGISLSQGMTGIWNSGFPYQYCSQVFTAVMFALGAAKASIKSIEILSRNANHLRDFAFNIPKFMEPSVVPVLQGLEKLHLCIDLSWRTPHVGLPAIVGSSRYSPDLFIRNFLAHATNLTNLRINEHRTNSLGLASLIDWMVDGGSDGTATSMPKLQELSLGTMNIDAPRLLKLISKFALSLESLELWKVTMLRHLPSDAPSPAPKEIFWAHFLKKLIEIPCLELRHFKMGMLQQHWIEKPVPAHVAFKGRGPTRQYTGPDWRQFVTEIMPELEVQWPYEAADETDEDNDITDEVLEGLELGLFDDDEMEIPNPAELLIQELLESNDHVHFTTHAPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQT1</accession>
    <name>A0A7D5YQT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdc4</name>
        <name evidence="4" type="ORF">G6M90_00g021430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548404.1">
        <property type="nucleotide sequence ID" value="XM_014692918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQT1"/>
    <dbReference type="GeneID" id="26237848"/>
    <dbReference type="KEGG" id="mbrn:26237848"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16411" checksum="D225B0F7315332DF" modified="2021-02-10" version="1">MSSNQYDSQASTNYKEAFALFDKRGNGRVTVDSLGDLLRACGQNPTLSEIKDLEQNAGSEFDFETFQRILNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGVGQIKYILTNLGEKMSEDEVDELLKAVDTSSGQVNYTDLVRTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRY0</accession>
    <name>A0A7D5YRY0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH:quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">QuiR</name>
        <name evidence="4" type="ORF">G6M90_00g038960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547252.2">
        <property type="nucleotide sequence ID" value="XM_014691766.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRY0"/>
    <dbReference type="GeneID" id="26239815"/>
    <dbReference type="KEGG" id="mbrn:26239815"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="330" mass="35403" checksum="F103D82DB56C8CDD" modified="2021-02-10" version="1">MPIVTELTKRLGIRVPVVQGGMMHIGTADLASAVSNAGGLGIITALIFPTPAALRDEIRRCRTLTKKPFAVNITLLPAMVPPDYGAYAQAIIDEGIKIVETAGNSPGPVIKQLKKAGIIVLHKCTTIRHAQSAVKLGVDFLSIDGFECAGHVGESDITNFILLGRARQTLKVPFIASGGFADGHGLAAALLLGASGINMGTRFMATVEAPVHQNIKEAIVKSDEHDTTLLLRRWRNTSRLFKNKVALDALKIEKESQSGEFSEIAPLVSGKRGKEVFVNGDPEHGVWTTGPVMGLIHDVPTCDVLVKRIEKEAEQAFKERSALIVPESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTI1</accession>
    <name>A0A7D5YTI1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiolase-like protein type 1 additional C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g065880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540185.1">
        <property type="nucleotide sequence ID" value="XM_014684699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTI1"/>
    <dbReference type="GeneID" id="26246994"/>
    <dbReference type="KEGG" id="mbrn:26246994"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="4">
        <location>
            <begin position="429"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="525" mass="56724" checksum="0D93D50CD498DBFA" modified="2021-02-10" version="1">MATQQPAVPIIVGVGDVRNKSFKVEDAVEPAQLMVNAVRRAVDDSGLDHAAQESLLAHVDSLRVVPTWTWAYNDLPAVISHRLGIKPTRRVLGEHGGNQPALQCDEAARDIAARRSLVSVLTGGEALASRKSFPLAACQKAGENPPKGWLEPDPNGKQLASLDLSILKESSGTLHSMGLPIHVYPLYENGRRAHRGLSAAESAAESAKMYAEFDRIGSENVYSWNYQQPPKTAEQIGLVSKKNRMICDPYPLLMNAFNGVNLSAACILTSTEHAKKLGIPQDRWIYVLGGAGTHEKDNFWERRHLHHSEAITKSIDAALHVSGLSASDVDCYDFYSCFPIVPKLACDHVGLSTTSWQKPITLLGGLTSFGGAGNNYSMHAITAMARELRAKRHSTGLILANGGMLTHQHALCLSARPRGDGQAYPTSNPLPEVVDGYSPPFTEAAEGTATIETYTIEYNRDGTPGLGLIVGRLRGTGRRFLANHGDELTLSQLATTAAEHVGKTGSVRTGEDGRNLFFLDAKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUG0</accession>
    <name>A0A7D5YUG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BET4</name>
        <name evidence="9" type="ORF">G6M90_00g020750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985741.1">
        <property type="nucleotide sequence ID" value="XM_066129861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26237916"/>
    <dbReference type="KEGG" id="mbrn:26237916"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="451"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="772"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1268"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1493"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1497"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1774" mass="197292" checksum="70649041B670025D" modified="2021-02-10" version="1">MSSDPLLPIAPARVRALLLPLGKIKTQRFAEFVKLLQAEYVVHLRDISADGRPNRNMFSPLAYPDGAMLYDLITHVPPVSHLALSPFDLYREPLVLIALADGEELQDKTFSKRYSANRAATTVERNVHALYQELEELRDNYPKVLVHQVVIFDYISPEGVDVHTPEEILFVPPKDKRKRTTIKTVMCDISSLVLAEMTTLAKSFEGMSTIESPGLYSAKNMNGNTWGGNGDGSPASLSRRNSQFSLPQQLSRSSSASSVADRTQTRLSMPPTTSRSPSNAAGRPSTPPRSGLSTTPMSPNGGQSGSSTGPSSPDQKPQRSDVNGSRDLSRDRVSVQGFGPGGANDRWRLRGKGRTSVLIGSMYLQAGRWGDSLRELSEGATAARSLNDHIWHGKALELIIMNLVLLGWSKLEFQIPTVCLPSHERSTSISGVLKSEADSANYSQPKHIRHLQNLLPELLDRILGLFSRISSENLPPLPLAETTIRFCKLQSAMHFSGGMLDQKAFGAIVTGELPTQTLTTSPRFTVTPSRQQIVNMLFKAFPSSGTELLTTADRTSILSGIANVLGALGYHRKKAMVIRELVSVLIAGLVEARTRGAAEAGIHPAAGLVSLVPGSDRTSAAGVALDLGEGDIEHGIEPFLELLCRSYGVVGFDMRKKRDGADDSDSATVARALIQSSTRFFGFTEIKLNILRACINFSEALPDFDGVLKFSSDLMRTAGSGIAPGPKREDAAPHIHKDEQVRLVTNIARTAALTERIGLGGLAAEYWDEFLVRGIALEPLPNTRTPIPHAKSVLPGANASRASQDVNPFIYNPFLKEPDEVAAENLVAGELATFKVTLQNTYDVEVDIESMRLDTEGVDFEPVPENVILGPYRTQLVRLKGRPKASGSIKITGAVVKIRGCRERRFPIFARHWTPSRAEKIKSKGPPTLEGGSRTAPVKPEMKVLNLNVVQPQPLVVVKSTSLAQSSVMILEGERQVFTVTMQNTSTTTPVDFLLFSFKDSTQGPLQAALENREATPAELYEYELVLMKKQALRLPRNNQNRYIPPGGEATFEFEILGKPGLTHAAIQADYTCLGVPRDEVTEQFYTRQVLLDLTVTVNASVELSRIDAVSVQGQVPPALLKRVGGDERTASPDKYFLLAVDLRNAWPSQMSVQLEGEDGMMVGDSILPGKTSRVVIPMKRVYLEDPHESVPSLNPSRNRQFVVSTSKISPDMERANREAFWYREKLLENLKATWQTTSVPKRNGVVELRNIRLTPRMIEAIKFDEVDIAVSIDGAPDNVAYVDEFMQMRVQIANRTAKPILPLVRLMPALCHRPLNVALDYTRKFAWNGALQQQLPKLKGHQVTEFVIGVTALCRGEFELAASVEEAQVLDGGLKEGRDLGHRRSDTQKLMDAALGVKERRVWYARQPCTLRHGVARTFRVRTEEQRLQDLEKIRKYRALEDEVRDKAASAAYTPELFQLTSKLLSINPEYYTIWNIRRRCLLSSLLSPATSHQPPDTRDSAPDHVEQQASSDRDVLQSELSFTIPLLMQSPKCYWIWNFRQWTLSQAILRLPAPAARQIWQTELGLTSKMLDKDQRNFHAWSYRRLVVGRLESPELQGRSMAEDEFSYTTRVIHRDLSNFSAWHNRSQLMARLLEERGAGAQQRAALLAEELHLVREALNVGPEDQSLWYYHRFLVAQIVDRGGVGGTFVPDLTADEKAAYLGREIDEIKELLEDYDDIKWIYESLLEYTLALGRLDQGRGRAGDLRGWLAKLRVLDPMRIGRWDDIERQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUH9</accession>
    <name>A0A7D5YUH9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Neurofibromin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Nf1</name>
        <name evidence="5" type="ORF">G6M90_00g007850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985755.1">
        <property type="nucleotide sequence ID" value="XM_066129639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239167"/>
    <dbReference type="KEGG" id="mbrn:26239167"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05392">
        <property type="entry name" value="RasGAP_Neurofibromin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028870225" evidence="3">
        <location>
            <begin position="33"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="862"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2226" mass="248312" checksum="960BF70B2C91E65E" modified="2021-02-10" version="1">MTQTGIDHGRRRAVLYPLQITLLLLLPDVFEVASNLREAKSNNLIKKVSFLDSLRKGLRNGNERAAYCLVSLLRAARHFEAESDSALVSYAMDVQDEIRESVFSLSQSNIATPQFDQDMITGAFVSLAHLGLDGSVETLTKACISPPAPNSFKIAVIQACSYFARLARRSETAKYTALQTSVLVLIRSEFESEYMNFFKARHELSQDGSRKILEILRYFYASPGPLLRDLSGETAGMAFLKPFLFCVLSRDQSIRQLATKVANKLFIMNKDSVGTSQLEYCGATEELGQNLWIRSSSILLELCGEIEKDISLSTITQLREFLGARSALLKGMPILSHLPMDVPDIHLAASKLETTLLISICSPNIAVCQLATICIGLLVDECTHVGEYTDSAKLLSSTYRNQLVYQELSSPAFHFTGLVAFQKRMRGFLRQIRLPTQGIVDAWETAFRQWIHLSKEVSLATADGVDDRMLSEWRNLSGFLASLGGICTYGYATKLDEAIGDLNWIDRVSSEHHEEPLLSRFLRLSIQLLGCNNIKVREAMREVLSTEVSSILYAPLFKALESELEVLLAGVLASPDKGQENEVIFAEQAASLLKIMVEKLESPSDLGSISSVHPGVLTLSFAKFLDGALDGVATLRVKVKICHLCEAVTKRKEHLNLRDDIRIRNQLLEYIFGWIARPHALKQEQLGNGPRQDEFRRVQKDLDKACLRTLGDLTFRLPLQPADSQSDAGMSELKSQMFHTYFNRFLSLLNYETQEMSRQELPLMGNREEGLSNADMVITILSNLLSANIDVGLKHSLNIGYHENVDIRAAFVRVLCNILTQGTEFSSLTDAAVSDKYVELLNLLTTDLSLSVSMSAICPASEVDELTICLLTVFEQRGLTFELFEALIRQEVEQTENETEILRRTCVATKMLSVYAKWKGASYLRTTLQKVLERLMLTSNDLDLELDPARVSTPGELQKNAAQLQIVAKVFMDDICASTSNVPSSFRRICSIISDAVLPRFPNAKYTAVGAFVFLRFFCPAIVAPEAEGLVSVAPTKEMRRGLLLIAKIIQNLANNVLFGTKEPYMFPLNPFLVQNIHLVTGFLRDISVSTRQADVAPPAIDMFDFGSCVSLHRFLYDHWDHLRQTLVSRERKEHLRTPVEIARTPPSVFEPLRDLISNLGPPPLAISWNRPQISCNTPPLYSRFQNFMLRNAFRSAESFLTSRAVYDGGESKDGLSIVCVILRHIENESIDYDTLLYCYLKIASRLWHEPFGLFIDATCYNGRSEPSDEFFSKLDLLTPSELSRNLSRIYIYNMNSAFKRCFRRLLRNSTRDDSSVFHPDNVEYYLIGSLQDLQVHFHLSQLHLPKETISVVTETRYMFQTITRLSKSKGKVEVVIKVGSQFLQITTVKKQEVLSGLRLSSVINDIFRLSDIEEASTPQAEDDSNFGLRADGGKIVMFFTSSKRADILQTIRGAKTIHGKDSRMVKPVERLVRPQDVPGTMLNLALTNLSSPYHVLRLASYNLLGALCRSFDFGVSGRLVCNRDLAVPLEPTRFIVDISRELAQAEPQLTSDFLTEFFVSWDSIPDEQKPLSLEYVAPWLPGLRTAVLVVEVDGDKGRDKVASLLRKLIDISVLDQNLTYCLEKYIWPCIAQDELLLEIFTDELIKAALSYGNGADTLEILSSVMVGLGTVTLRARIISRLRKALNRSSLRPTRLLQDNSVWEEICILLQFCLGLSFDSRVQSQMFLPEIFHVVTMLANTGGSEVRLLVYKLLINSIHAICASFSIDDAKLVRLRSILDVFGDTRGDIFTAPTLLARDGASVSTSFDSGPALASTENLTSVLFEVCLIAAPSMDIANAWRARWMSLVASTAFQNNPAVQPRAFAVMGYLAREEVDDDLLYQVLVALRNSVSQFGEDGNSEMLVSIITSLSKMMAKLPSSSRYGLQLFWLAMSLVRLVPAAIFNCAAQFLGAILTNIGTIGNVRGDRMVPLLLQCRGQLEDAALPLDDAYGIRFEEDTFHFAVCACLVRGLTDTATRPTAIQVLSSFLEMTSRSEDPAPGSPNHAIHGSPYLALLLARGMQEDFMDSLWWSDLKPEAISDILDSRGVQGVDNMKDKDLLLISAMELVDFHSLEDAAQARSLHWLNSLAEARPFVFTSLCGALPSVLDDVLLHSQESAALEAAHVLLRTLASDQKYAQAMGSMQSLNSQLTEMGFGGLWKIPKQSTVEDAKGECFELTEKLIELIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUP2</accession>
    <name>A0A7D5YUP2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidial pigment polyketide synthase alb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alb1</name>
        <name evidence="2" type="ORF">G6M90_00g081270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543366.1">
        <property type="nucleotide sequence ID" value="XM_014687880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUP2"/>
    <dbReference type="GeneID" id="26243543"/>
    <dbReference type="KEGG" id="mbrn:26243543"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase TesA-like" evidence="1">
        <location>
            <begin position="142"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="375" mass="41208" checksum="4EB76C4C81BDCAEC" modified="2021-02-10" version="1">MAVTVWQDALNIIAQESGLEPAEIIETEDTAFLTLGINQILATAILAHLRGPRGEPLPRDIFDQKPTVGAFRRFYETPIHLDIAPVAAPAPPKLKRVPSSSVPLSIVLQNNPASSRHTVFLLPDGSGSAMAYANLPPVHPAVCIVGMNSPYLRDAGSYRCSVEDLASQWVREVYRRQPRGPYIVGGWSAGGYYSYEVAKRLLQDGHAVAKLILIDSPCRTVFESLSMDVVNYLSSRNLMGNWGSPEMPEWLVQHFRSTLAAVGKYRPRPIGSAGKMQTYIIWSRDGVLDHDALARSGLDTSVKVSRFLLQGKDDLGPNGWDDLLPSKDMAIATQSGTHFTMINKPHVAQMSDLLRDAVIGIGSDRQSHWQRVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVQ9</accession>
    <name>A0A7D5YVQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">suv3</name>
        <name evidence="14" type="ORF">G6M90_00g070780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539349.1">
        <property type="nucleotide sequence ID" value="XM_014683863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVQ9"/>
    <dbReference type="GeneID" id="26247855"/>
    <dbReference type="KEGG" id="mbrn:26247855"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="312"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="652"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="717" mass="80713" checksum="D765DF02B72BDEEC" modified="2021-02-10" version="1">MTDRNRNEQVSQGHDPKSRLRLGVGKKYTGRHGVFRSTVLHRLQVVLNNRSASQPAGQGIAEDELNRQAALFMNAIDHAFLLAEQNVTRRDKNPLFWNLRDAFITRDIKGLTKELQYSFQSFVVRQTFSKELEDNQRRLLDFRFPHEWFPATRTMQRTIHVHVGPTNSGKTYNALKALENSKMGVYAGPLRLLATEVYQRLTAKGRPCALITGEEIRIPEDTDQYFSSCTVEMVPLNTKFDVAVIDEIQMIADPERGNAWTTAVLGVQAKEVHLCGEDRTVPLLQALCASIGDKCVVHRYERLSPLKTMDSAIKGDYSNLQKGDAIVAFSRLSLHVLKRNVETATGRRCAIIYGSLPPEVRVQQAALFNDPNNDYDFIVASDAIGMGLNLEIRRVVLESITKFDGNQNRLLTYPEIKQIGGRAGRYRTAQSAVGVNAEEAEKEKVGLVTTMDQADLRNVERAFQKKVNDIEYASIQPPAGIVERFASYFPPDTPLSFILMRIKAAATVGPRYRLNISSDVLEIADIIQDLPLTIYDRLTFCYLPVALRAEGAVDVLRALARVVGHNSAGDLLSIKEIPLEFLEVKMEDYPGGSQEYLSKLEALHVAINQYLWLSYRYAGMFASQALAFHVRHLVEEKLITTLDRLDFTEEQLEHKRKNKRRQARSRDISRKAIGEDEGHELEHEHEQDDAQLPASSGKGEKLSGGGQHEKPIEVGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVY9</accession>
    <name>A0A7D5YVY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g076640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987254.1">
        <property type="nucleotide sequence ID" value="XM_066131059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVY9"/>
    <dbReference type="GeneID" id="90967986"/>
    <dbReference type="KEGG" id="mbrn:90967986"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7070" checksum="79742F73004B7C61" modified="2021-02-10" version="1">MREDDDVMEEDERWDLVHGRQTGEANGRPASGSETSGRRSSSSAAAAAASISRLRSVNPKMMECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVZ2</accession>
    <name>A0A7D5YVZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ring-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g006130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549894.1">
        <property type="nucleotide sequence ID" value="XM_014694408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVZ2"/>
    <dbReference type="GeneID" id="26239338"/>
    <dbReference type="KEGG" id="mbrn:26239338"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="43825" checksum="24BF4C1D4C8DB54C" modified="2021-02-10" version="1">MLEYFTYKKVKKHKAEKAAKEEARQAAEAATRTDTSAAESSSNNKHAHGHDHDTRHRRHDGHEAVIRPDDESFLEELLANDDVPAPPLPPRLYLRDLDWPSDTDDATPSTSQQAPPPPGKPADSESDKDKDKDKEPKKPNRISALFTRSKPKDDALKPLPTTAPAEQEKEKKDLSKVLDRLNLSVKNNKVISTDSSAALQSFTNVFKDLVNGVPTAYDDLMGIVDDKDGALAKGFDKLPNSLKKLVTQLPDKLTSSLGPELLAAAAASQGIKADSSSGLKGAAKSVFVPANLLQLVTKPGAIVGMLRAIVEVLKTRWPAFIGLNVMWGVALSLLLFVLWYCHKRGREVRLEGERTVDGSDRIEELADDPALPAPEPPGRVSTLRDEDAEVVEAPGRRNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWE3</accession>
    <name>A0A7D5YWE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g019760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548567.1">
        <property type="nucleotide sequence ID" value="XM_014693081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWE3"/>
    <dbReference type="GeneID" id="26238011"/>
    <dbReference type="KEGG" id="mbrn:26238011"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="502" mass="55815" checksum="4EFD119B10355030" modified="2021-02-10" version="1">MAGSSIDEKSEQHTEYVEAHMQSHRQATGQCWQSPMNIDAKEESRIRLKMDFGLIPLVSLLYLLSFIDRSNIGNARLAGLENDLGLRNYDYNASLSVFYISYIVFEIPCNALCKYMGPGWFIPSITLGFGILTICTAFVTNFATLCAVRFLLGILEAGMMPSLVYFLSRWYRQSELTFRVSLFIISASLAGAFGGLLASAILRLDSFGSLHSWRMIFAIEGTATAVLGIICFFALPDRPETALWLTQSEKELAIARLKADRIVTTELVDQFSWKRIRLGIFNPVVLPTSVIFLLNSITVHGVSFFLPTIVKTIFPAHSVSNQQLLTVPPYVLGAITCAATSYVSWRVNRRGIFMILCAPLTVVGYAMFLASTNPNVRYGATFLPFMGIFTYGALTNSHVAANVVSDTAKSSAIATNVMLGNMGGLISTWAFLPSDAPHYKVGNGLNLAAQASMIIIATVLYFWVKRDNQRRETLDAVAELEGKTMQEIQDMDWKHPEFRWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWH9</accession>
    <name>A0A7D5YWH9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g079310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987192.1">
        <property type="nucleotide sequence ID" value="XM_066131123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWH9"/>
    <dbReference type="GeneID" id="90968021"/>
    <dbReference type="KEGG" id="mbrn:90968021"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="437" mass="47899" checksum="E98552E41D4D8B24" modified="2021-02-10" version="1">MANRNSTTLRQVLTQQKPLLPCTSTSNRNTTHGSWPKLDEYVVIWDEFNLKTLNESYGHLLDAAVPDTLLASPQADEVLAGLVVHTAEDINHLISWNHGLMEPTLRFAKSRLGLHPGLALYQKYSTPDKSLMVSLPGAAGRLTVNHIVALDDFPGGHLVVGLGRTSSKWSGRTVAHQLNSSTSVKKELIWPLRQLGNICKAAQTRYGYIQTDEELVVCCFSKIAQDEWKVALMPVPWTRSGADVLTTDLALWWLCMLAMSAQCHREIVDDGEMVKIDKWDEAYLDERRGWGRIHRYSGFEKPTNPRPASAGNVAATVVYSGVHVDPLFGINPAAVDRRADVFGHGTVNPSAVSLNAVNPSAVNFDAVNPGAVNFDAVNFVNFDTVNYAAVPHDAVNYGAVNFDAVNFDSTTNFSTVNPRAVNQNAGARTRLAPGERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXM6</accession>
    <name>A0A7D5YXM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g097780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546564.1">
        <property type="nucleotide sequence ID" value="XM_014691078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXM6"/>
    <dbReference type="GeneID" id="26240987"/>
    <dbReference type="KEGG" id="mbrn:26240987"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44152" checksum="A18483A1233DBC3C" modified="2021-02-10" version="1">MPVKSLSELATAACLKNLKELGSIGDYLPYEAVRHLLLKLESAHQLRQIELSSPQIQGHTGEIWLKLIEKDFPLEYKAKAYKPQNPDKWYRVWEKYKRGHDAALEESENKLKNALAGLRQDKEKNTSRIIERKLLPKSVKLGGPKRPFGGPREAHSNSLSFNSGSRTKTVNGASVMRKVRREVKEIATIHGALSRPNRAPTQRLQMRKAPESMVNDYRRASQPQYRSSALSPEPPSAVAEHEERATFISDSEEDEEGNGDLSDDEVAKMPAKPAKKFVAQSAATSLLKRRPNTSQATSSPSTTIKRVSASNTASSPVKNSSSLTNKFNRSADKSPPASPPKPQSGSVTTHENNSNNQSKASPPLPTASGSSLSPHAESVAPRVMPRKRKAVDVFMRPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXU4</accession>
    <name>A0A7D5YXU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDI_1</name>
        <name evidence="18" type="ORF">G6M90_00g097390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546602.1">
        <property type="nucleotide sequence ID" value="XM_014691116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXU4"/>
    <dbReference type="GeneID" id="26241025"/>
    <dbReference type="KEGG" id="mbrn:26241025"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029033258" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="337"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="467"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="387"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="513" mass="56438" checksum="920C0C703FF423AD" modified="2021-02-10" version="1">MQHKRIAFGLLAAFASLASADDSDVHQLTEKTFKDFVKANPLVLAEFFAPWCGHCKALAPEYEEAATTLKEKDIKLAKIDCTEEAELCKEHGVEGYPTLKVFRGVDNVAPYNGQRKAAAITSYMVKQSLPAVSLLTKDTLEEFKTADKVVVVAYLAADDKASNETFTTVAEKLRDNYLFGGVNDAAVAEAEGVKFPSIVLYKSFDEGKNTYTEKFDVEAIEKFAKTAATPLIGEVGPETYADYMSAGIPLAYIFAETQEERDGLSKDLKPIAEKYKGKINFATIDAKSFGAHAGNLNLKTDKFPAFAIHETVKNLKFPYDQDKKITKDAIAKFADDYSAGKIEPSIKSEPIPENQDGPVTIIVAKNYDQIVLDDKKDVLVEFYAPWCGHCKALAPKYDQLGEAYKKSEFKDKVVIAKVDATANDVPDDISGFPTIKLFPAGNKDGAVTYDGARTVEGLIEFIKEKGKHSAAISFKEESTEEAAPAASEKAEKEKKEEKTEKAEEKDDEDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYC4</accession>
    <name>A0A7D5YYC4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M7GpppX diphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nhm1</name>
        <name evidence="3" type="ORF">G6M90_00g024320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548149.1">
        <property type="nucleotide sequence ID" value="XM_014692663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYC4"/>
    <dbReference type="GeneID" id="26237593"/>
    <dbReference type="KEGG" id="mbrn:26237593"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000016">
        <property type="entry name" value="Scavenger mRNA decapping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="37716" checksum="8ACB9A89FCE7A5A1" modified="2021-02-10" version="1">MAEFNARAEALVPKFQLERVLNQDQAGRRTSMYGTIDNEPALLIVERAPFPTSDKYLGRIPSSLARLKNLGANDIYSWSMARTGSDDEEESNKEKAGFFADLKINLIYPCTETHVQKYSKQQVRFVTETPEIYRASIRPYMQSKRDQGRLNWVFNIIEGRKEVEDVIYRTKLGEAGDEGFLLLPDLNWDRSTLEALHLLAIVERRDIWSLRDLKKKHIPWLEHMKNKLISATVETYPSIEPDQLKLYVHYQPTYYHFHIHIVHVALEAGATQATGKAFGLDVLIEMLKVMAGDEEAGMDAVSMTYTLGEASELWTEVYEPLKKSGRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYW2</accession>
    <name>A0A7D5YYW2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANKRD50_8</name>
        <name evidence="9" type="ORF">G6M90_00g106330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987804.1">
        <property type="nucleotide sequence ID" value="XM_066131704.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247619"/>
    <dbReference type="KEGG" id="mbrn:26247619"/>
    <dbReference type="OrthoDB" id="5243355at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="8">
        <location>
            <begin position="325"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="962"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1199"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1610"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1817"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1845" mass="206027" checksum="3564EF14A6F7C1DC" modified="2021-02-10" version="1">MDTAFSDEASEHSATRSDPGNHIQAGCWNDGLKVISILGRRGMNPDDVTPDIDIVHVTGLRRESDRLSIDSILKSSITTLRREILFPCDIAQLLVGDFTRDVVHTTALRLLNSLACLADKDASKRNQKSKHAIIFVAYDLGALILKTALSVAEKERYNWPDTFTSSARVIFYGAPQRSDSLFIMESKLYEFLHDDKNTPWLHMLTPSSIRGLAQAALESTDEFLSSKFTLRGRIVSLYANSRTPRKIHPAFDEEAATLGVPLEESLGEMDWDNADASSLLATKICHLVEQWVPHPDQVAAEQTLLSLAVPDSQFGITKPMESHPILKDTEHQKWIEGRGHRLIYVHGTDRNASIVAAEQIFAKCRQRMQALGIPQGCAFSFSFSSRDPLRRSASSMISTMIAHDLTTHRKQTALHGLVLDQYHVQNGWTEQDTMLWLNMRWLGEPSSYRCILLHDFDECDKQSRTEFLNFFNTRADGCEFNAKILVTSRQPGALLDEVAIWPEINIDRLCSPEEKFKGAGSLEGPGLDGFATAASTSRDPFRLLPDLDLTRTYAARLERGRHQLKAMDYDRSNFILELLQAQSAWPEDISTRSLTKFANLLDLISPTTTAKDMLVIILQSLPDTGAVQWILKWLVHSYRPLTRVELATILYLQPVKGAQPSSDASPAALAEALSNITNWLRGVVDIYQDQMVIRSEVWNIFMEDAGTENRLLRDNSDVCHSTILDFCLAYLSEPDVQEKAMRIYQLYLSQVRRAAGDKISPPMMPDGRDPLFYFIVALPYHALQDPCRREKITTLLKNRDKCLEVWSKLWWAMSNSLSRPREPPRCAYPLLAGLGLVDYRKLGTSSRERSQILILAAANKKKDVVVDLLGALTEYSLSTLTNALEAATKAGDEDLALLIEKVLGFWHKPSREQPLNVQQNISWPPSLLWRAVQLNMVRLMKVLLENGMRADPEIFNDYFFPSPLHIASVLGNAHAARMLLNHGADPMLVSNEQHEEIRFTALTRASAAGHGAVIKLLLSKEPLLLHNGYPMEVLGVLGRRQWQLSTPLSMASCTGHWKAVEALVQAGADPDPDLMYEEVEGGGGKEKDCSVSPLCFASMNGWLQTCKALLENGADVNRLGYMGKFDALFCAAVFAASVPCCWALIARGANPNGQAQPLLVELVLGRSSLQPRPVTETIAVLDVFLDHRPRLDIDQTDSAGLTALMHASKRGSLPLVKWCLEHGANIKAVDNQGQSSLFYAVDAGCFDVVRDLLTWEVNLVTDAILQRALDGGNLALLERLLRAGKDSDSASESVNTLIRLAIHARNADAVKMLIKFKPDINRLDEYGWSPLCDAVGYVPDTKIARLLIDAGANVGQILEDSRRNLMHLAMGADADVIRLLFEFPKAVDIDHRDKFGNTPLMVTDNTTKVECVRHLLKAGADINAQNSDGLTPLMNAIACDAPSEVIQCYLSQPQLDPNIYSKIHGSALHVACRTLDKDIVNGLIRIGSDVNQHLPAPALSPLIVVCIPFPDVSLKKRENTDYIVHALIRAGANVNSTSKMAQHDSHRALSTASLWARTSTLEIFLYEGADVEARDPVGRQAIHFAAANGVGNLRAVMRFFEGSVAIADSSGKTALHWAAQFGRLQAFKLLLSTMSPDERMRRVNEPDIDGWTPLCWAMRTSPIVWNHMSEPFECKGLVQCLLQEGADPSIQCWIGEGQDKECFTLLHLAYLHDADEKMVALIRDALTKAIDTHQRRTEWEGKTCSLYKPRDVLCDVCLCQIYGLEYVCKICPDFRVCKKCYGRIDRYHNRFEDDITPFLPHIFEVPDHEEFMDTTDVVETEENTSTKMRKEDDEEIEENSRWGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYX5</accession>
    <name>A0A7D5YYX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tether containing UBX domain for GLUT4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Aspscr1</name>
        <name evidence="3" type="ORF">G6M90_00g097220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546619.1">
        <property type="nucleotide sequence ID" value="XM_014691133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYX5"/>
    <dbReference type="GeneID" id="26241042"/>
    <dbReference type="KEGG" id="mbrn:26241042"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="505" mass="55135" checksum="E8B67DA80CE0D6BD" modified="2021-02-10" version="1">MASHVVVIATDLRRATVKVNPGTYLSDVLDQACQKLNLSSDKYLVKHKQKQVDLSVPFRTSGLAGGAKLELVLRSKTPSAVQIALQIPQPDAKEIPGGRLIKKFPSDLTLWKVMRQFESGEASAGKNVNITARGYANTTSGSGQLYYETPVLNIMGREFSSFPEFQKTLAQLGHNSGNVLIRLGYKRTEQTLFEAMEKISTFFKDGEENSGSDVKVDETKTEEAREESQQQGDTTMTDGVPEPEVAQEDSAQSQPEPEPVLSTAPVEQDAPKECATASSPTAQDPFQPINVFLAPTGTTPAAALVPASETDFTPTIAHAQLHQARLLESSRNKRLLSDKELEEKAAAEEARIASIQSILVKVRFPDNTSSEWQVSPSETGAFLYQAVRHVMADATQQFHLVLPGGKDIIKDSNAENHNLVKSYKLSGRVLVNLVWEDSVPAAIRKQPFLRANVANQGQAVKVPDLPKVDDAPEPGPATEAPKKENKKDKGDGTTKKPKWFKLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZA0</accession>
    <name>A0A7D5YZA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain-containing protein DDL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DDL</name>
        <name evidence="3" type="ORF">G6M90_00g044110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547745.1">
        <property type="nucleotide sequence ID" value="XM_014692259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZA0"/>
    <dbReference type="GeneID" id="26240308"/>
    <dbReference type="KEGG" id="mbrn:26240308"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22676">
        <property type="entry name" value="FHA_SNIP1_DDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="306" mass="35244" checksum="CC83750B5DFFE1CF" modified="2021-02-10" version="1">MAPVGDYADRPTQRPARDDDMDRRDSHRSSRRAPDGGRQERQRSRDRRRRSRTPDSPGRHRRRRHRSHDGERERGSGGNLDIRSGRQERARNDERSDRRRRRRDDGESDEDRRRDRRNPVKQGGPLPSQEDSFAIVKGEEPEKPKEKPNFGSSGALAAASNSIAQADGSSIVLKYHEPPEARKPPTRDQWKLFVFKGGDIVDTIDLSLRSCWLVGREMAVVDLPAEHPSISKQHAVIQFRYTEKRNEYGDKIGRVKPYLIDLESANGTVLNDSKVPDSRYLELRDKDMIQFGNSTREYVVMLAPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z063</accession>
    <name>A0A7D5Z063_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IBR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g022720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985985.1">
        <property type="nucleotide sequence ID" value="XM_066129895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z063"/>
    <dbReference type="GeneID" id="90967497"/>
    <dbReference type="KEGG" id="mbrn:90967497"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IBR" evidence="6">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="40334" checksum="375AD6D3FDFAD516" modified="2021-02-10" version="1">MSCPNDPETADILAQAKEEGWKRCYRCKALVELKEGCNHMTCRCGAEFCMICGIKWKNCDCPWFNDDDRRADFLNDMNISIPSIRGDLGDIFRGNGPPAPPELRGHTEPPPMMMPVRRRPRTYQEEMHMRRQQESFDADFARQLQYTGDYDEPHSYSMMGGLGDIHGIGNASEHYMNENYRRGGHYRPQTQTTAVHDRPEYGDTRRSRGRLETSQERRLADRLSETRSGFGSPPAAGPIYPVGMSVPPPPVPAAPVPIPPSLALRHHTVEAEMYNISPYTPRTERVVGRRMSRDYEDEARVHSPPRSHWRRGRETRPKSSELAGLNGTGQGMNRVSQWRAFVEPGIPDGESTVGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z091</accession>
    <name>A0A7D5Z091_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dioxygenase swnH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">swnH1_1</name>
        <name evidence="8" type="ORF">G6M90_00g031240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543063.1">
        <property type="nucleotide sequence ID" value="XM_014687577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z091"/>
    <dbReference type="GeneID" id="26243864"/>
    <dbReference type="KEGG" id="mbrn:26243864"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="308" mass="34530" checksum="641069AD6BBACF19" modified="2021-02-10" version="1">MDQPPELFPTNYKPSIRIAELSANAPIEEILSVIDRDGGVIINGLVSSEELESIEKEIEMYTKADRSEDEGFFKDLVPQETILIGGLVGKSDTMARICEHPVLEELRTHILTDVGTRRVEKYDLPYHIDPLLSVSLSFRIQYGAPRQRLHRDDGTHLIEHESKPYKLNNAAQFGCLIAGVETTQENGATMFIPGSHRWDDKREPRLDEVTFAEMKPGAALIFLASCWHGAGHNSVPGFTRVLHGLFFCRGTYRTQENQFLAIPRSKALSMSPKMLNLLGYKQPGAALGMVENADPMLDLEHFLEEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z098</accession>
    <name>A0A7D5Z098_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g005830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549921.1">
        <property type="nucleotide sequence ID" value="XM_014694435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z098"/>
    <dbReference type="GeneID" id="26239365"/>
    <dbReference type="KEGG" id="mbrn:26239365"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="91" mass="9601" checksum="6883FCEEA4E9C936" modified="2021-02-10" version="1">MSTSISTVAWIGTGNNGKPLLDIVAASGKFKITLLVRKPPVKYTNIVPDSVTVKQVDFQSHASLVAAFRGIDAVVSVMTFGPQSGIDVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0G6</accession>
    <name>A0A7D5Z0G6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g113480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539757.2">
        <property type="nucleotide sequence ID" value="XM_014684271.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0G6"/>
    <dbReference type="GeneID" id="26247422"/>
    <dbReference type="KEGG" id="mbrn:26247422"/>
    <dbReference type="OrthoDB" id="5150075at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="5">
        <location>
            <begin position="239"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="490"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="757" mass="84989" checksum="44ECBE79E1349E9C" modified="2021-02-10" version="1">MSPGTLKYVTIALTVNEDLQNLSIDLLLALQNIRASRLLRSGGNGKNLLSDLLRVNSTVNSGEFDFDHIKPLLKVALADSLDDTLIWNHVYDIVTETTPPPRAIASSIQQTPWSQNTSSFVNSSELRQDVDRVLKQELGPLYVGVPNFCDTFFKGVPDLGTIAETVFSKCTEGDNPLFSGGWTGWPTGAKESDVLAWFVDLIPRLDAFEDDRNSTLPHRRKLLAQPKTPLLGSTGKRSMDIGFVNSDITYKPDAADSKYRWSHVLVAGELKSNPKADIASIAWIDLARYAREVLAAQDTRRFVLGFTLCGSLMRVWEFDRLGGVASEQFDINKEEGGLQFVTTILGFLRMNEEILGFDPTIITTGGQKYIEIERNGQTECLIIEEVMKRAPCIAGRATTCWKAHRKDDPRTPLVIKDSWQYTDRDEEGELLQEATEKGVINVARYYHHETVRVRGGEDDVRSSVRQALDVTKAENYRPSRPMQPSGMRASSVSRKGRSSSGGVKRPSSDLGVALPPTKRTCSTSPTKLGMDALSNRIHRRVILRDYGKLVYKASSRVALLAAMERCIQGHESLYNAGFLHRDISINNLMINEDEENPSWAAFLIDLDLAIRDQRGPASGAKGKTGTRAFMAIGALLGQYHSFMHDLESFFWVLFWICIHYNGPGEDIGATEFEKWNYVDMRELAKLKKGEVSDERDFLKTAEENFTSHYRCLIPCINNLRKVVFPNGRRWEREDSQLYSSMKNILREAQRDTKVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0K3</accession>
    <name>A0A7D5Z0K3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mannan polymerase II complex ANP1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ANP1_0</name>
        <name evidence="10" type="ORF">G6M90_00g073020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545761.1">
        <property type="nucleotide sequence ID" value="XM_014690275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0K3"/>
    <dbReference type="GeneID" id="26241794"/>
    <dbReference type="KEGG" id="mbrn:26241794"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF2">
        <property type="entry name" value="MANNAN POLYMERASE II COMPLEX ANP1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="53232" checksum="8BB874EF4AA81C2A" modified="2021-02-10" version="1">MMPRHQGSGFSNGYPRGNTFDISPHRFQPRTSAPGNRRQRKFLIRVGLAVIGLLVISVWLWPSNPILSVVSLGLFSATNDVELETVRYYDLSNVQGTARGWEREERILLCVPLRDAEAHLAMFFSHLRNFTYPHHLIDLAFLVSDSKDRTLQVLTDNLERIQADPDPKQPYGEVSIIEKDFGQKVNQDVESRHGFAAQASRRKLMAQARNWLLSAALRPYHSWVYWRDVDVETAPFTILEDLMRHNKDVIVPNVWRPLPDWLGGEQPYDLNSWQESETALALADTLDEDAVIVEGYAEYATWRPHLAYLRDPYGDPDMEMEIDGVGGVSILAKAKVFRTGVHFPAFSFQKHAETEGFGKMAKRMQYSVVGLPHYVIWHLYEPSVDDIRHMEEMEQERIAREKEEQEKKLKEQKLKEEFGDASSQWEKDKKEMREQQQQSKRSSVASPELHQAEDAAKDSGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0V5</accession>
    <name>A0A7D5Z0V5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g105920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987957.1">
        <property type="nucleotide sequence ID" value="XM_066131690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0V5"/>
    <dbReference type="GeneID" id="26247911"/>
    <dbReference type="KEGG" id="mbrn:26247911"/>
    <dbReference type="OrthoDB" id="5153416at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028991720" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="199"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="375" mass="40319" checksum="11E791FBA24E5BBE" modified="2021-02-10" version="1">MVAVSGIWLLCLSLASLSQTTAATESKHGTSASRSDSFLFQSRAIYPKGVKLNSTSEDATLAEALKLVQEASKQQGDYNAHRVANPKRNEEISKASAARSKRTANAGPRAPTLTPALRKAAAIIAEHQAKQNANKTQPEYPQPRHLKPRTGSSSGSLDARDLTSKYWLQDIKHTGLAPMGANSSWPVFRDVTNPMFAGGAKGDGVHDDTDAINAAIAYGGNCGEGCLSSSVKGTLVYFPPGKYLISTPINTMYYSQLVGNANDVPTIVISKDFVGLGAIQSDVYIPNQNGDEWYIEQSNFYRQTTTKKTAAFHWQVAQATSMTNVYIYTSTDPGTNQMGLFTENGSDGFMSDVYISGGKYGICTLAITLIVMEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z303</accession>
    <name>A0A7D5Z303_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ERG12_1</name>
        <name evidence="22" type="ORF">G6M90_00g030670</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 19"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539668.1">
        <property type="nucleotide sequence ID" value="XM_014684182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z303"/>
    <dbReference type="GeneID" id="26247579"/>
    <dbReference type="KEGG" id="mbrn:26247579"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="20">
        <location>
            <begin position="137"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="21">
        <location>
            <begin position="315"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QLI67807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="458" mass="49490" checksum="F49FBE7A5A3E66CF" modified="2021-02-10" version="1">MVMGRKESSPLAPTFMVSAPGKVIVFGEHAAVFGKPAIAAAISLRSYLLVTTLSKSQRTVKLNFKDIGLNHTWKIDTLPWGVFHEPEKKKFYYSLVDSLDPELLEAVIPHAEAVSKHLPETQRKIHVRSATAFLYLFLSLGSPLSPGFVYTLRSTIPIGAGLGSSASVCVCLSAALLLQIRSLAGPHPDQPAEEAQVQIERISRWAFVGELCIHGDPSGVDNAVSAGGKAVIYKRNYSGPPSVTPLTKFPKLPLLLVNTQQPRSTATQVDKVRALKNNHPVVTQSILDGIGHLTTSALELISSADLDSSGLSDTLERLGTLIRINHGFLVSLGVSHPRLERIRELVDYADIGWTKLTGAGGGGCAITLFRPDAKDETIKGLETKFTAEGFQKYETILGADGVAVLWPAVFRNNIGGEGGEEIDQEIFENVVGVEGIEQLVGVGAREDREGWKFWARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z331</accession>
    <name>A0A7D5Z331_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSM23</name>
        <name evidence="8" type="ORF">G6M90_00g011900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549332.1">
        <property type="nucleotide sequence ID" value="XM_014693846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z331"/>
    <dbReference type="GeneID" id="26238776"/>
    <dbReference type="KEGG" id="mbrn:26238776"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017082">
        <property type="entry name" value="Ribosomal_mS29_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036996">
        <property type="entry name" value="RSM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="464" mass="51719" checksum="9341571E82572DE4" modified="2021-02-10" version="1">MASSATSSLRSLVRPSIPLAPRIHPVILSRVAFLSTTSARAAAPPPTIKSRRDLPKKVKRTFKKKTNVVAVKKPNPGERKAFRKRIQLSNNSALPVRNIDELTPETMANLESKGKMFALPDKVVDQLRALEAFKTTQTWNLFRRPHFLVREETAQLVIKMEKSIEKKEALKCVLTGSKLSGKSLALLQSMSYALMNDWVVVHIPEGQDLTNANTEYSPVEGTEPMQFAQPVYTLKLLQNIYKANKAVLEKLALQKDWSRFTHLKQGATVADLVLSAKESENAWPTLEALWTELTLPGRPPVLLALDGLAHINKMSEYRDSSFNQVHAHELSLVRLFVDALSGKTKLPNGGAIVAATSDNNTHYHPSQELVLSQLEAGQAGREIPKPDPYERKYDERVYESLKNSYVLRIGGVSKDEGRALMEYWGASGMLRSVLNTSTVTEKWALGGHGIVGEMERVSLMTMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z425</accession>
    <name>A0A7D5Z425_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g074420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545624.1">
        <property type="nucleotide sequence ID" value="XM_014690138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z425"/>
    <dbReference type="GeneID" id="26241657"/>
    <dbReference type="KEGG" id="mbrn:26241657"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="121" mass="13303" checksum="9B6AC059D4094256" modified="2021-02-10" version="1">MAGRFEPKVPVQLNPPKDDPISVEELAKATGVDGGKCYVAIKGKVYDVTGNKAYQPGGSYHVFAGKDASRALGKTSTKPEDVKAEWHDLEDKEKETLNDWIIFFSKRYNVVGVVEGAKNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4B9</accession>
    <name>A0A7D5Z4B9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynactin, isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ro-3</name>
        <name evidence="16" type="ORF">G6M90_00g049200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545029.1">
        <property type="nucleotide sequence ID" value="XM_014689543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26242370"/>
    <dbReference type="KEGG" id="mbrn:26242370"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="79"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI68446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1333" mass="148057" checksum="7A46050AD71E054D" modified="2021-02-10" version="1">MPDFKPGQIVQLSDGRKATVRFAGQTNFQVGEWIGVELEDKTGKNDGSVQGVRYFDCPAGYGMFVKPMMATIIAQAPSTKPVGRKPARPSSFHPASVKAAPSGDVALAKRRSLNAPSPSPVPKSRPTSLVRSPAKSPTKQLSAASSASASRTGTPSNARVPSTSAVGAARARTSASGQRTPMGPPTVPAPRTARVSSISSTTARVGGVHARSVSGARPPQSMRTVSRPDSGRRPSTDSQAGRDSGSADDAGPGSPIKSDGEILSPQPTSPVAGRAKALEKIAAATSPGTSSTPPLSKRTTAAVTTQRSAPNSALNRENEDLKAKLKVLERKRLEDRDKLNQLDRVQSERDKFEGIIQKLQQKYQPQQQENAELRKQMKEAEARFISIEKEQADLEAELELSVVNRQIAELDLEDSQSQVEALKLKTEELELKVDLLEAENSDYCKGMSPEERASAGWMQMESTNERLREALIRLRDITQDQEKELRDQIAGLEEDIKELGPVKEHHDLTKEKLIRSEQVVEQLKEQLNDALGAQSMIEELSEQNMDMSSMIEKLKLEITELETLKEIDDELEANHVQLEKQMQEELDIRDTIISEQVQRAGRQQGELDDRAHTILRFRELVESLQADLDDMRASQAVTEGESEKLNDRSRAMMDLNMKLQISVAKAQVKTIDLELRHLDAQEAEQHLEIVKLFLPDTYREDQDSVLALLRFRRLAFKANLVNGLIKERINGQPQPGHEDDLLAGCDAVDKLVWVAAVCDRFINDISHCTTEQFSAYQNSLLELEPVERALNSWIDGLRRDDLKEKKCAEELQRTIALMSHLAELHISNGLPNFADYVYMSSLVVQSHLDSAAIAFNATRVMVQRAISSEAEEDEMSQLFAKKFDMVITQTRSTKVIAGKAVRALEDLKTRSLSLLPDTKPVFEQCEHNSRELANIARAIGNHVHLLLTQDEGRVEPFTYGEIQSAVHQAVLEATSASESEMFSAYFSKLRIVTGQINDVAALATDLDQTEEFDVHPAPWKLRSQELKVLKTVPADAEEELRRLREEHNEARRTIAQRDEHLSTAVLKIDTLESRMRDAQTNVERISSLQKQLEASGEQVTILKEDIEKQDRELKGLESERDKWKKIASDSRAYADGADAAGMKAGQERAVATAREMDALKKNIEGLQSAVRYLREDNHRARMTEQQNYDWLAEPLKKPTSTREQRSALVVAEGKDVLGELVKMATASRMFDFGTLPKDKLAWKPAKSTPQYLAAKQMEDFAAWNAWQRSVLRKSSMLRTPDAGKSLLRNPAAQLRIRLPGPDGKIKTGSALGCDVQVVGSREWEALQSSSIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z535</accession>
    <name>A0A7D5Z535_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline ceramidase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Acer3_1</name>
        <name evidence="10" type="ORF">G6M90_00g083960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543612.1">
        <property type="nucleotide sequence ID" value="XM_014688126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z535"/>
    <dbReference type="GeneID" id="26243789"/>
    <dbReference type="KEGG" id="mbrn:26243789"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="266" mass="30627" checksum="90D037A86BAE6810" modified="2021-02-10" version="1">MGHHNIRYDGDPYSLTGVWGPPNSRANFCEEDYILTRFLAEFVNSLTNLAYVYLALRYMYGPGSRGLLSPKLDFMSISLLSLGFGSFLFHASLRQTLEFADEFSMLGLTWSMLQATLTLRQSPLRSRSISIGLAFVFITFAGFYIQSPRIIYQVIAFATGILLVILRTQYLYHWLQPAPFAKAKSRDWNSRTWKAIGVCLIGYVLWNIDLEYCATLRAVRRQVGLPWAWLFEFHGLWHVLTAIGASQFMNVAREMREEVYLEKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z562</accession>
    <name>A0A7D5Z562_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g085070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541065.1">
        <property type="nucleotide sequence ID" value="XM_014685579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z562"/>
    <dbReference type="GeneID" id="26246054"/>
    <dbReference type="KEGG" id="mbrn:26246054"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="298" mass="33001" checksum="D7C78D574EF83803" modified="2021-02-10" version="1">MSANTSTAFVEANGAQVFYRKAGPSSADAPTVLLLHGFPSSSHQFRNLMPLLAAQGYRVLAPDLPGFGFTTVPDNYTHSFDNLGTTIDAFASALSLQKYAIYIFDYGAPTGLRLALKNPEKVVAIISQNGNAYDEGLGAEFWAPVRKYWASGADEDRNALRGLLESDATKWQYTHGSPNAGKVQPEAYALDQALMDRVGNKDVQLDLFYDYRSNVALYPKFQEYLRTSKVPVLAIWGKNDVIFVPPGAEAFRRDVEKLEVKLLDAGHFAIETNEEEFAASIVSFFEKFQVFGSRERKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5S4</accession>
    <name>A0A7D5Z5S4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g084910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541051.1">
        <property type="nucleotide sequence ID" value="XM_014685565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5S4"/>
    <dbReference type="GeneID" id="26246040"/>
    <dbReference type="KEGG" id="mbrn:26246040"/>
    <dbReference type="OrthoDB" id="4971707at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="314" mass="35302" checksum="C23F91486E88A043" modified="2021-02-10" version="1">MHTNKKPLWLVCPRLDAAEYREKLMGSVIKYPDLPTERRIPYRASELPKDLVADLDPKPVQVYNVRFWEKNIHDASLKTTVQDMINAFVARAKESSNENVATVARVWHMDSPGEKFKDLLRNTQYFDELMGLLLSNHGVGYFVSDIVTLVNLEETKTHGTGSAVGVTAQVPVDPSTGIKVGAGAKFSVIREKGHSVSYEGESIVFMGYRKIELEKVNGIRAKLRRFFQGPKHGVAIKDRHDYWPELVEEPVEGTVGPFLGKNDKETPGEETAEMRAVREEKERLAQEENERSQMLDAIAEELGIDPVVGCNHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z665</accession>
    <name>A0A7D5Z665_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB/POZ domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">btb1</name>
        <name evidence="5" type="ORF">G6M90_00g039410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691809.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239858"/>
    <dbReference type="KEGG" id="mbrn:26239858"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="329"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="382"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="907"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1160"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1319"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1506"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1445"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1513"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1539"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1592" mass="175962" checksum="9D4B512CA474FDD9" modified="2021-02-10" version="1">MSHLVWKFYWENDVEKFRRLLAPAGPNTHALTKSPGIGNSGGGLLGTSPGGPSSSPRVTPKARKTSGYTYGLGKFKDGGAMLSRHEINSRDHAGLTVLLRAASSTHPNARDFVQALLEHPSLDLYAQDSESGWNALHRSLYAGNISIARMLLAKERTDLTDRTNISSAVKVGQLIKTKDHEGNSPFDLYNSTIAMRSLKQDPSSMKSNDGLDDEDSDGETAQMVANAAFGIGQPVMGDEFYVFGSNKNLSLGVGDEDDRQYPERIVLERPDELLLKFHKEYLDSQDIESPPSQPDLNDIPTLVRNQRLAIRDIVMSKFHTAVLTDDPVSNLYICGVGRRGRLGLGDENTQFKFVPVQGPFIDRKIRQVALGQDHSMAVTETGELWTWGLNSDSQLGYALPPVMRSDEEPMSLSPRQVFGPLKKEIVQGIAASAIHSVAHTGSSLYCWGRNFGQLALMDADSRSLELQQIPRKVAASLLSAPIEMVSAIEKATTCLLSNYTVWIFTNYGYNLVKFPYPDVFSNQNLSASSYTNRYEMGRRNIRYIASGGETMAAITTCGDLFTMQLNSKMDTNQLAGSTTNPVKIKSAVTKPQCVWDSRKDGVASVSVGEHGSVIICTDSGAVWKRVKRAKGKITAFDSALDVKKKDFKFERVPYITNCVGVRSSTYGAFSAIRNDSKVMSTDINITSQSIWDDVGSLLCLNDFRASTLDADEKRSRKKWDAAIAREKPGSVPHEILRSANIEQDLLQWIQVNSFQYDDLNMEIRTSLNPDLRLPVHSWLLAGRSSVLREALSTYQSNDDKGTLTDVITIEQNDDRALLTFIGIDIYTLLNLIVYAYLDVVIPVWKYTKEAPTLAYRFRQVRTELMKLGTRLNMPKLEAAARLQVGLEPSLDQNLREAIADPIFFNDADMIIEVDGDEVLAHSHLICQRCPFFEGMFHGRSQGHWLAARRSTSLEAELIRVDLKHINPETFRYVMEYLYADVGEGVFNNVCMDTLDEFSELVLDVMGVANELMLDRLSQICQSLIGKFVTTRNIANLLNEISPCSVTEFKDVGLEYICLQLESMLENHLLDGLDEDLLLHLDEAARNNQLARLPCARSGRAELLLHEQYPDLALDIEEERRRRVREMAFKLAQKDEEKKLSASYKARVGSLDESVLAAQTLERSHHRSRAAQNEPFSPHLRPKDSIADLIFDMDDEDGPKISSPMSPAVLAALDAKNEYNLDNIPKLPEAWRGTKGKSLADADSGSSPSLDRISPSQLPGPSIEPVRRAGSSHQPISLPARPANAPWASPILPASKLDLKDIMQEATSKSALTAGLASQAEKAISSNKPQARMSQKERKRQQVQQAEAEAAAEKEKNNPVPWQAVHSAARPAPWKTTPSTPKTSLKDAMQSESAQGGGPPTLSKKPLVAAESNPQLSKRRTASPDTRFPGQCRTAGSPAAPAVSYGPSSEKNLPVTQSKPYIKPAVKAEPTLGMSMADIIGQQRLEQQRVKEAVAKRSLQEIQEEQAFQEWWDQESRRTQEEEARRQARDKEKDQGGGNRRGRKGRGGKQKPSGNLGGAEKTDEVSTKRTGNNTGPSKGRGGRARGSKHDTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6K5</accession>
    <name>A0A7D5Z6K5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ilv-2</name>
        <name evidence="21" type="ORF">G6M90_00g076300</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545471.1">
        <property type="nucleotide sequence ID" value="XM_014689985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6K5"/>
    <dbReference type="GeneID" id="26241504"/>
    <dbReference type="KEGG" id="mbrn:26241504"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="21" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="61"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="252"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="300"/>
        </location>
        <ligand>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI70487.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="401" mass="44703" checksum="FE08AB8FE2544D8A" modified="2021-02-10" version="1">MASRGFSKSLRAARQLAAPRVQQRSYIAARQLVRAATAARPAVAVAQQQVRGVKTIDFAGHKEDVYERSDWPQEKLLDYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKNGKSWQDAIQDGWVPGKNLFEVDDAISRGTIVMNLLSDAAQSETWPAIKPQLVEGKTLYFSHGFSPVFKDLTKVDVPSNIDVILCAPKGSGRTVRSLFREGRGINSSFAVYQDVTGKAKEKAVAMGVAIGSGYLYETTFEKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGANGMDWMFEACSTTARRGAIDWTPKFKDALKPVFNNLYDSVRDGTETQRSLDYNSQADYRQRYEAEMEEIRNLEIWRAGKAVRSLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">4556</strain>
        </source>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="71" mass="8279" checksum="6A92BD4A4DA15A6D" modified="2021-02-10" version="1">MGSRGFYISDTEASLLATSERQRRPATLGWCLVKIARVRRRVLEGLVGMWMAEKHREHSEEHCCRKYDANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name evidence="2" type="ORF">G6M90_00g077200</name>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="573" mass="63117" checksum="88AB4DAEC2D9EFEA" modified="2021-02-10" version="1">MTADSIQMACMADLGRQRQEELPLSNKEGKGKGPSFAPSRRNGTGHIAPDLKKGLETKWNVQINDEESEQMKGLAVEDSRPWAKKIAQDFISRHQVFTAPPRIRQESKGHKRVKANYFQKTPAASLGGLIPPGGSVRHFSASKSTRRLLPKSPVRSIIANGPGTPLNTNNCDLQTLRSDPKSTMASPSPGPAVPAEQSHGSPTPVSMSLPIRPSEPQDPEHIVLRGICKLLNPKDRSVLFVVSYIMKVRKDTDEGYLVLSSSGKEDRIHNVLELMAPDTRDDCCRVCSRAEKNGFAYILQFPNIPDAHKFKIYLESLQQAAAREASMEQAPTPAKAAQEPPTSPHTSRPVVDSPSPGMELIDLRSPSCSQTAQREFIIEDAAEKLLGLIDKILPEASEAGLVLSDDTVAHIQEVAINDWLHRGFLASETDDMKTDLLELLRILVRIKRRAESRRQALPVTQSFQGFDVESRSNRITYSASELEMINIEMINTMQHQEAPTGKFIKYAASELEMINKMQPQESPMGKFIKYTASELARMGGAAMSAQSPRIADNGATASRPSTRGLGTSRWARD</sequence>
</entry>
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    <accession>A0A7D5Z8N5</accession>
    <name>A0A7D5Z8N5_9HYPO</name>
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        <submittedName>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
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        <property type="protein sequence ID" value="QLI72207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245343"/>
    <dbReference type="KEGG" id="mbrn:26245343"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="572"/>
        </location>
    </feature>
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            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI72207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z914</accession>
    <name>A0A7D5Z914_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g071800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545879.1">
        <property type="nucleotide sequence ID" value="XM_014690393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z914"/>
    <dbReference type="GeneID" id="26241912"/>
    <dbReference type="KEGG" id="mbrn:26241912"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="78"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="348" mass="37738" checksum="C3362F531BCFBB63" modified="2021-02-10" version="1">MAQVNGGGSSSSKAPAPAYESQGKMNVEPPRQEDLQQSYATLIGNDPNPKGWYGSMINTIGACIGTMGAIPLCFCCPNPYKNVNQGNVGLITKFGRFYKAVDPGLVKVNPLSEKLLQIDVKIQTSEVPEQFCMTKDNVTLRLTSVIYYHIVAPHKAAFGISNVRQALLERTQTTLRHVIGARVLQDVIERREEIADSIREIIEDVAAGWGVQVESMLIKDIIFSQDLQESLSMAAQSKRIGESKVIAAKAEVESAKLMRQAADILSSAPAMQIRYLEAMQAMAKSANSKVIFLPGSSQNMTAFNNALNATHEIGEGSGHNRNDNSNNDFGGQDPGLQAAINARVVENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBI0</accession>
    <name>A0A7D5ZBI0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">abcB_7</name>
        <name evidence="15" type="ORF">G6M90_00g081030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987386.1">
        <property type="nucleotide sequence ID" value="XM_066131169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247772"/>
    <dbReference type="KEGG" id="mbrn:26247772"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028812346" evidence="12">
        <location>
            <begin position="22"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="821"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="857"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="979"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="205"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="540"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="822"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1157"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI72089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1400" mass="154666" checksum="0684B2BEFA94CA2E" modified="2021-02-10" version="1">MTFSVYIALQIVLLALWASSAAPSTKTTLATVSLTIAGFILFANLSYLEHTRSLRPSTPITIYLGISILLDLARVRTLFFIPGSQSVAKVNLASFCVKLIIFLLELTEKRRLLLPAWQDASPEAVGSVYNRVLFWWLNSLFMKGFRNLISINSLPVLDTELLKTANPTELVEKWNRVDASKKNALLWTFLLHYKWDLLAGVVPRLACIGFTFAQPFLLERVLDFTAEPVESSRKEFAYGLIGAYAIVYIGKAATFTAYQHKTYRLLTMFRGSLISLIFSKTLRMSATKISDAEAITLMSADIDRIALSLELVHEFYSSFIEIALSMWLLYRLLGVAMAAATAHVVGIPIAAAAGNANVPWLEAIERRLAVTTKMLGSMKAIKMTGLTNVMSNVISSLRSLEIGASRRHRIFTVLEAVTSYTSDAFSSVWGFGVFILLARSNNTTTLTEGIAFSALSLFSLQVQPLTFILNGFEDIQTIINSFNRIQEHLASEEREDPRDTPETRKNLERDSSSETSLGFGEPKAVPLGSVSALGDTNAAIVIKDATTGYSAESSILNGINLEISRGKTTVVVGPVGCGKSTLLRLILGEMPVTSGTVSTSFSRAAFCPQSPWITWGTIQNNIIGMSRWDKPWYNTVVKACALSADFEQLRDGDQTNVGTRGSRLSGGQQMRLSLARALYSRNQVMVLDDVLTGLDRATEASILDAVFGPSGLLRSSQTTVVLTTNSINHVQYADYIVILNKDGTVAEQGTRDSLSTSVGYIERLSGIVQGTTVRPEFELAEETLQELGLPDEDEEQDVTSRGTSDWRIYAYFIHIAGKWTFLLYLFGCACFIFGLNFPSIWLQWWTNANAKTPNDKIGYWLGIYGLLGALAVLGCFASDWIFNIILLPKISRKFHELLLATTMKQVLPFTCLLLFNFLTSLLSAPTSFLTSTDAGQIANRFSQDLQLVDNDLAHALDQTVVQLFTVVISAVLVFTGSGYLAATVPVCIFFVYMIQFYYLRTSRQLRIIDIEAKAPLFSQFLETLAGVSCIRAYGWTDNYLQRNYHVLNTSQRPYYLLWCIQRWLNLVLDLMVGGIAVILVAFATATAGGKTGYLGVALFGIINFSGTLQTLIAQWTQLETALGAISRIRSYVSNTPSENQGANTRHPPEGWPLSGTIEFSNVSASYQSSQEPVLKDVNLSINAGEKVAICGRTGSGKTSLISTLLRLLELDTGSVTIDGVDISTIPRQEVRLRLNTLPQEPFFLQASIRDNVDLLHLSDDDSIIAALRSVNLWQMLEERGGLDEMISEELLSHGQRQLFCLARAIVKPSSIVIIDEATSSVNSDEEEIMERFLQDDFRGRTIIAVAHKLHTVLDFDRVVLMDKGHILENGNPRELLANSESAFHSLYMSLSTVSEKKQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBN7</accession>
    <name>A0A7D5ZBN7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pct1</name>
        <name evidence="11" type="ORF">G6M90_00g095310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546799.1">
        <property type="nucleotide sequence ID" value="XM_014691313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBN7"/>
    <dbReference type="GeneID" id="26241222"/>
    <dbReference type="KEGG" id="mbrn:26241222"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="522"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="812" mass="89036" checksum="1E0676465EABB59D" modified="2021-02-10" version="1">MDLRDVLNTSDNGERGPPKAPPTPQQQHQSRPAQSPAQYGYREYGQQPPHPSPGKPIGQDYPRHPHQQPPSAYPPPSPYQTSPVQYPPRASQSLPHHSGPFHDARSPGGMPVPAQSPYRPTPTPTNAPGGSTGYPFPATQVVQEMTSPNQRHHYPPGHYAQQSQSQDVYAQRDGAHSSGGYVQQRQVPQTPPISTAAGPSQQYLHQRSQSTQSTPTPTSAHSQQHFGPPHAHGSPVQASRPSIEYRQPSQPPTPLGPPQTTSARPAPGLPGSFTHPPSPYQQRVASLGNGPQPQSPASANATLRRVSGPGHQESPVADPHQRSKSLHSREPSLSISPRTRVASIASNSDRAMASPVDMEKKSLPISQTVIVDLDRAVTPAKRKLDDRNLSPKELEHKEARPPPSELNGAHIGNSQTTPAQSAPRKKRISRAQPPIWAQNAHSLGGKMPNQANFVLQKRIHSHINGKVDGGSKADRSSRNASPEAARTSTSTASKPAPAVVEAGPQDILGPWEASITGVKPYEEISKTVADFVFIHVVNNPDIKEITSRGIQFEIEAKLGTLIDKDTNYRVDRLLDTECVLHDTGRVAFKSSMTEAHHKAFNDFLNQIVIQTDPRAPNGAGRVQVHYKHRREVDRYFELPPDLQNRLPGCVRSRLGSRVRNAKARVTYDQKTGQVLNKIIKARVADIDIHMPNSPMDCRLSINLEMNWDGPVEELERLGPTQNDKSSERQKDRLSYTQGHYQIDLTQVTLSTPGPSSTQKMEKEHELEIELASAIVLDQGAKAMSGAPHRYQELIEGFLDNVRVLARKAREFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCL2</accession>
    <name>A0A7D5ZCL2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">cdcA</name>
        <name evidence="17" type="ORF">G6M90_00g101250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546220.1">
        <property type="nucleotide sequence ID" value="XM_014690734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCL2"/>
    <dbReference type="GeneID" id="26240643"/>
    <dbReference type="KEGG" id="mbrn:26240643"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="224"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="301"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="547"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI72989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="619" mass="69076" checksum="EDA437E05A574FC6" modified="2021-02-10" version="1">MASSVLFADRLYLGAYVHPPTADTLFPGSESPVASRKRSHKTLDSVSSVGSGRSAPCYFTVDDTLLYNAFHHDFGPLHIGHLYRFAIRFHDILGAKENKDRPVVFWSAADPRSRANAACMLACYMVLIQNWPPHLALAPIAQVDPPLMPFRDAGYSQADYGITVQDVVYGVWKAKEEKCIDLDNFDLEMYEKFERVEHGDFNWITPHFLAFASPQHTPVAKVTEDSELWPLLPRDLGAVDAHPTLPQPFKNVLKHFSEKNIGLVVRLNSHLYSPSYFEALGIQHLDMIFDDGTCPPLTTVRKFIRLAHETITVKKKGIAVHCKAGLGRTGCLIGAYLIYRHGFTADEIISFMRFMRPGMVVGPQQHWLHLNQGTFREWWVEERVERRLRRELAAANPAPSTPIRAMQKTSLRNGQMSTPPNRSPSNRTPLSEVDQDRKNGAQEDYLPAPTPGQPRKSTRAADRHHPYFRSGATHRPSIEEEREGLNETEIVAMHRYTQGSDSDEELHVRMRSHRKASASPSRERVRAVSQTTSTIYLIDNDASHDAENIGSGRSKTVDRVASTPSVMTRVRGSKRAGSESPLRAKDSAGIRKTSGRVGSSSMSVSASAMSTARKVSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDT3</accession>
    <name>A0A7D5ZDT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Dbt</name>
        <name evidence="14" type="ORF">G6M90_00g100210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546328.1">
        <property type="nucleotide sequence ID" value="XM_014690842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDT3"/>
    <dbReference type="GeneID" id="26240751"/>
    <dbReference type="KEGG" id="mbrn:26240751"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="501" mass="53807" checksum="D64EB56ADD77C592" modified="2021-02-10" version="1">MFLQRGSRVLRRQLQTSKAMGKLATGRGTLAGGPTMPRWFTESRRLYAVKPVLLADIGEGIVECEVIQWFVEPGARVEEFSPLCEVQSDKASVEITSRFTGTVKKLYYDAGEMAKVGKPFVDIDIEGDAEPEAPAPSQAQQPLASAPSTPSTPSPSEPPSGQGGAGAASPMAPSQRSGDDAPAAPKPKGKMAALATPAVRHLSKELNIDIIEIDGTGKDGRVLKEDIYRFVKAREEGDSGTQSPSAPVPAHTPGVQTETRTPLSQTQQMMFKSMTRSLNIPHFLYADEIDFTSLVALRARLNKVLASSTVQDGQPDKLSYLPFIIKAVSMALYQFPILNARVEVDSPGANGKPALIMRSQHNIGVAMDTPQGLLVPVIKDVGSRNIISIAAELVRLQKLAHQGKLTPADMSGGTITVSNIGNIGGTYLSPVIVEKELSILGIGRMRTVPAFDGNDNVVKKHVCNFSWSADHRVVDGATMARAAEVVRTVVEEPDIMVMHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPD1</accession>
    <name>A0A7D5UPD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">THIO_0</name>
        <name evidence="4" type="ORF">G6M90_00g025830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548000.1">
        <property type="nucleotide sequence ID" value="XM_014692514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPD1"/>
    <dbReference type="GeneID" id="26237444"/>
    <dbReference type="KEGG" id="mbrn:26237444"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="127" mass="13666" checksum="7E9B75C897F695C4" modified="2021-02-10" version="1">MAHAAQHITSPEELEALLSSTTYVVVDFFADWCPPCRTIAPIFESLAAKHSKSGYLAFAKVNVDHVQAVAQKYRISAMPTFLFFKEGKQVAVNGQSMIQGVDPKSLGAAAEKLAGLAAQRAEEAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPL8</accession>
    <name>A0A7D5UPL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IMP4</name>
        <name evidence="3" type="ORF">G6M90_00g010960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549425.1">
        <property type="nucleotide sequence ID" value="XM_014693939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPL8"/>
    <dbReference type="GeneID" id="26238869"/>
    <dbReference type="KEGG" id="mbrn:26238869"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="298" mass="33685" checksum="3682BCBE9BB1F1E4" modified="2021-02-10" version="1">MIRKQARQRRDYLYRRALLLRDAEVSEKRAKLRASLASGKPLDPSIANDKSLRKDYQYDESTPDLGVNEQLDLDDEYAQLSGIVDPRVLVSTSRDPSARLSAFAKEIRLLLPTSIRMNRGNLILPDLVKSAQSAGLSDIVLLHEHRGTPTALTLSHFPHGPTVSFSLHNVVLRHDIPGSVRGTVSESYPHLIFDGFTSPLGKRIVKVLKHLFPPREAITSKNKMGNRVVTFKNIEDSIEVRHHVFVRTGYDSVELAEVGPRMTMRPFEIRGGTLENKDGDVEWHLSQYTRTAKKKNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPX2</accession>
    <name>A0A7D5UPX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">T-complex protein 1 subunit theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g014060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549116.1">
        <property type="nucleotide sequence ID" value="XM_014693630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPX2"/>
    <dbReference type="GeneID" id="26238560"/>
    <dbReference type="KEGG" id="mbrn:26238560"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="68093" checksum="28E098A94D34D5E5" modified="2021-02-10" version="1">MQHQRRKEPPTTTTTKAASTTLDHHRFSGGAISTGELSSGKHKNHDKSAASITTAAASTRRKPECGEPLLVLRLTSHRLATMSLNIPNAPNAGLFKQGYNNYDSEDGAVLRNIDACRAIASTVQTSLGPYGRNKVVINHLQKMILTSDAATILRELDVVHPAAKLLVMASQQQEAEMGDATNLVIILAGELLRKAEDLLRMGLKTSDVVMGYEKAQNFALETLEKLAVDKVEDIRDQEELSKAIRTVIASKQNGNEDFLADLVAEAVLAVLPKNPTNFNVDNIRVVKIMGGSLEQSRVVKGMVFPKEPDGSVKKARRAKVAVFTCPIDTSQTETKGTVLLHNAKEMMDFSKGEEAKLETAIKELHDSGLRVVVCGDKVGDLAMHYLNRFGILCIRILSKFELRRVCRVVGATPLARLGAPMPDEMGNIDVVETLEIGGDRVTVFRQEDEVTRTATLVLRGATQNHLDDVERAVDDGVNVVKAITRDPRLVPGAGATEIQLSARIQAQGEKTPGLSQYAIKKYGEAFEVIPRTLAESCGLDATEVLSKLYAAHHKNEDGDTGVDVENNDNTGTLDANSEGILDLLTSKSWAIKLATEAARTVLSVDQIIVARQAGGPKPPGPNPNWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ09</accession>
    <name>A0A7D5UQ09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Low-affinity glucose transporter HXT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HXT1</name>
        <name evidence="11" type="ORF">G6M90_00g000540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543013.1">
        <property type="nucleotide sequence ID" value="XM_014687527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ09"/>
    <dbReference type="GeneID" id="26244386"/>
    <dbReference type="KEGG" id="mbrn:26244386"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF92">
        <property type="entry name" value="LOW AFFINITY GLUCOSE TRANSPORTER MSTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
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    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="36"/>
            <end position="57"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="87"/>
            <end position="107"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="146"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="212"/>
            <end position="231"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="335"/>
            <end position="355"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="459"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
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    </feature>
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        <location>
            <begin position="43"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI63838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="537" mass="59057" checksum="7608B01750E21297" modified="2021-02-10" version="1">MVSAKRDSVHGEATNGEQQITEPKGRNDALLAEQKITFLACFQGGVASLGGFIFGYISGQISGFFLMQDFKERFGERQLDGSYNFSAARQGTIVGLVSIGALIGSLIAGKMADLIGRRLTISAAAFFTCVGTIIEISSSYHWAQFAVGRLVSGVSIGALSVVVPMYQSECAPAVIRGVIVASYQLLITLGIWTAEMVNWGTEAKTDSSSWRIPNGLSFAWALILGSTILFMPESPRYDCSRGRVDRARLAIAKLSGLAPDSEGVNHQLADIQNNLHEESRSADQFRLSEIFTAPRMLYRTVLGIVLQAGQQLTGANFFFYFGTTVFAATGISNSYVTQIILGSVNVFCTIIALWVTKRFGRRNTLMIGAAWMMMCFLVYAFVGHFALDHDNPMNTPKAGSALVTFSCLAIAAFAVSWGPLVWAVNAELYPLRYRSTCMGLATASNWLWNFLISFFTRFITDEIDYLYGLVFAGCCAALVVIVFFFVIESKDRSLEEIDTMYVQKVNPITSGHTSGHWNTNDYRQDIRRRSEAQTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ86</accession>
    <name>A0A7D5UQ86_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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            <begin position="1"/>
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            <begin position="8"/>
            <end position="21"/>
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            <end position="65"/>
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            <end position="151"/>
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            <begin position="159"/>
            <end position="244"/>
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        <source>
            <dbReference type="EMBL" id="QLI63997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="26928" checksum="189F021DF58E069C" modified="2021-02-10" version="1">MSYRDNDNSSYGGNNDSYGSSNRRDNDSYGSSGNTDSYGSSGRSGRDNDNSYGSSGNDSYGSSGRSGRDNDNSYGSSGSSGRDNDNSFGSSGNDSYGSSGRTGGSDSYGSSGNKSSSYGSSGNDSYGSSGRTGGSDSYGSSGNDSYGSSGRSGRDNDDSYGSSGRTGGSDSYGSSGNKSSSYGSSGNDSYGSSGRTGGSDSYGSSGNDSYGSGNKSSSYGSSDNTDSYGSSGRDNSSSSGSKVGQFLEKASDVLGGGNKGRSNQGRDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQP8</accession>
    <name>A0A7D5UQP8_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">G6M90_00g020560</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029002832" description="Aminoglycoside phosphotransferase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="551"/>
        </location>
    </feature>
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        <location>
            <begin position="136"/>
            <end position="367"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="551" mass="62515" checksum="183D097D6290FB56" modified="2021-02-10" version="1">MSAGPILSQLWCSFWAQLVKLPQYLSQLFCGLLHRGQSGHGSRGPLSSTSAERAKELLFSPDELIPGGQLHKSTPYPLTPQQVENSIETFIASINKSAICALASRHNGGKSCRIIDQRNGSFNICFFVLFDAEDVKWVVRIPIEPVISNTWAKVVSEVTTIKYIKSKTTIPCPDVYGYGHEDTLIEGVSTPFMLMECLHGQQLSTRAVLHATETQRRNLYIDLIDTLAQLRQLEFPAAGSLIPKSESLDNESDPIIGPLLSMTVNEFERQRAMPQATEVYTSMKDFIDLHSHILSETFQLPVQELEYRQAKMEIFALNSIAKEIRTCSELQEPSHLFVLAHPDLRCGNILVDDDFHILGIIDWEFTHTVPRQLLLPPPWITGHDPDTLLVITGVPRHQILQEFSRVLQEMHEASNGWTLLWQDWGFQQGIHLQVEGPLLRLSPVSQILRHPSSLMDVYYSSIFQRIFGSATCKDVVINDFFEDQENRELAMRVELQMQRSGRYTDHLKSRGLFIADERSQQLQDVLTNLQILMQARQEGLEKKGKNSISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQQ1</accession>
    <name>A0A7D5UQQ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">clr3</name>
        <name evidence="15" type="ORF">G6M90_00g008190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549688.1">
        <property type="nucleotide sequence ID" value="XM_014694202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQQ1"/>
    <dbReference type="GeneID" id="26239132"/>
    <dbReference type="KEGG" id="mbrn:26239132"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="84"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="462"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="Pfam" id="PF00850"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI64376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="744" mass="83180" checksum="8422A5F57B8F98E0" modified="2021-02-10" version="1">MEVDDHPMGDADMTNGTSHDNSVRPEDDDDTASDEASYDDGVYPDLQDLALEQLRRRGLLPTGCCYDDRMKLHMNADFSPNTHHPEDPRRIHEIFKAFKRAGLVYTGPEAELPKIIKECPTRYMWRIPARPATRQEICLAHSSEHMTWVEHLDKLSTAELREMTKRYDQGRESLYVGSMSFPAALLSAGGAIDICKNVVSGQVKNAFAVIRPPGHHAEYDAPMGFCFFNNVPVAVRVCQQDYADVCRKVLVLDWDVHHGNGIQNIFYEDPNVLYISIHVYQNGHFYPGKPPSPETPDGGIENCGAGPGLGKNINIGWHDQGMGDGEYMAAFQKIIMPIAKEFNPDLVVISAGFDAADGDELGGCFVTPPCYAHMTHMLMSLADGKVAVCLEGGYNLSAISNSAVAVARTLMGEPPPKMTIPKLNREAARTLAKVQAYQAPYWECMRPGIVDVPAVQSLNANRLHDVIRSAQRLVLQEKHNMVPLYVQRDQLYKSFENQVLVTPNLHNSRRILVIIHDPPQILAQPDPIDSSLQPHNAWVVDGVTRYIDWAISQKFGIMDINVPAYITNDEDADSYIPGYRERILQEQVQQLMNYLWDNFLQLYDADEIFLMGVGNAYLGVKVLLINRDCKSKLSGVVNFVTGNLRPVKSDIDPDLSLWYKENSRVYVAGDHACWSDHDLTKKVQKRRFGTVVRSPKLGLNKMMQEHADEVQGWILSRVSATSRGDTTEEEDEDDGNGIGGVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR81</accession>
    <name>A0A7D5UR81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g005880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
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        <location>
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            <end position="165"/>
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        </location>
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            <end position="218"/>
        </location>
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            <end position="283"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="308" mass="32843" checksum="59C254172E504FDB" modified="2021-02-10" version="1">MTSIPSVAANPSCAKKDYALLQSWKAAIEIVMLVLTAAPFGMAADAYGRKRILQLSVAGITSAQAFDIVIGRFPETFPVHLMVWKGFWVMMGGGGTVFSAMIFTIFSDISTEAQSNVPLMLAQQFSGRPDALDLAVQIYLSIMWSNILKVVVLTIILPLASYLLAKKLGLNPVMKDVYISAVSIVALVVGSLGIVVGKATGSALVVASIYIYALGCGYGPAMHSLLGLLSGGCHIGMLYAIIRAMQSVGNFMGGLLFGASFEMAPFLFTALFLVLGAGALFLIQLEDTQQRQPIWINLDDLVVHNVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USB5</accession>
    <name>A0A7D5USB5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g001360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985963.1">
        <property type="nucleotide sequence ID" value="XM_066129505.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244309"/>
    <dbReference type="KEGG" id="mbrn:26244309"/>
    <dbReference type="OrthoDB" id="4923306at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="38930" checksum="68A60A6C540261EC" modified="2021-02-10" version="1">MATKLGVDPTTWGYAGKNTCEKQESSQYCTRPEQGGWHPGPETCDYFKSLEVKLFLGNGISGFDGAGTFDDLVIEFGNSHQTILVHPSKGEESTKPIDLEKAFGLKRVKVEDVKSFKVYSVRDERTNPDSWEIGGISITATCDESSRKVIINKYDDIYDWFNRFGDITGNEPSHFTGSIAVSDWKWQHPDEKTDTIAVMPIGQSNACTKFKSMEAHLELGSGISALTAGTNDELVLDFSNEMFPKHVILLATAPSHGDVIDKTLDLQNEFGSSPVSALDVRQVMLYSREGKSHWADPWQVATFELRAKCEGSSRSVVVTKWRNIDKWFDRFEGPSALSGDLALKDWHWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USH2</accession>
    <name>A0A7D5USH2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorbicillinoid biosynthetic cluster transcription factor sor4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sor4</name>
        <name evidence="8" type="ORF">G6M90_00g000170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543047.2">
        <property type="nucleotide sequence ID" value="XM_014687561.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USH2"/>
    <dbReference type="GeneID" id="26244420"/>
    <dbReference type="KEGG" id="mbrn:26244420"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="493" mass="54821" checksum="A5BA68DBA9A345B6" modified="2021-02-10" version="1">MAVYACRYVYGGVLFGFRQCKASAHLRNKPPGYQLDNYDGRVAKLDCVISQLKMEIQVVRYKGLPKMRKEVELLSSAGNYSRFRGCYPRHSGQARPYNAFPAAEPSSHLERVRSCSTIPVPNSVNKEVLLNIVNTTTTTSSGDAGQEPELACEECRRRKARCDRVRPRCGICAESGRTCVVVDKRSQRGPKKGQLKDLRSRLMLLEQRLGGQPDSSNLPKERDSSPKPSKKVSPERDLISSSASTDIGLDMGSDPGALALFEPGSGLKQMPTLTPDLTTASTATSMAACICEGWQTEPGIFQNSYPQIPTPQSATAPGHMPSFDLLYFERVHPVAPMIHKRRYFAWAGDADTSPARTALRSAMRTIASAMSPQFCDIVQIMYALTRRMLKTQDACGETGLPWMARPKPPQEQQKIDHERIQAWLLLAYYDVLRNYGIQALVTARRAFRLLQLSGLYKMDAHRSHISTSPAETSWNAQLCLSNNEADEPILQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT83</accession>
    <name>A0A7D5UT83_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g040730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547421.1">
        <property type="nucleotide sequence ID" value="XM_014691935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT83"/>
    <dbReference type="GeneID" id="26239984"/>
    <dbReference type="KEGG" id="mbrn:26239984"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="705" mass="77982" checksum="22F19FA530ED6A15" modified="2021-02-10" version="1">MREADSIHLPLHLRLDPEKSASSIQHDGTSYRKKFPESLHFASGNFHMRSRTASTRSSISSAHIPDSATAYSPSTLASPLSSSYASDIQERFACHTLDGSRPSSRIRHRHRPSIATCSTFINDDDESPVYVGCQDVAQKIKQTGSDNSDPVETHEIEIDEPETDATPIKEEDDALTPGKDSDWEQNQTPCASPTQKSDISFNTFGDTVSSDDADGILDYTLQLVYGIELSEAQAPSGALHQVVSKFVQELGQHIWQAPLDGQSSQTMSGSSSSTTPSTGAGLDGAHSFGKRKKQSNGEDGGEDLTDGEGSGYIPSKRIKPSPKEDENLRLSCPYRKRNPHRFNVRDHHSCAMTYFPKFAELRQHIVKQHKRDDPSAFVCDRCTRDFRTRKELRDHQRQPKEHMCDISDHDPEAGIDGPTSNKLLSRKRVSGASPEVQWKEIWNILFPDDDDNLVRSYHFTPVIEHFELSAHYLEAFNYLQSSLRDKISNPATLETLATKFHQCFIETVERCVLTSQSMPYTNRSNKRNEPSRIQGTQILTSRKARGTASRPDSGVVIDDTSEESGSIVGSSSLGHRDSVRTVRSYAGRRGSNIAPKGNPDMFPTPVTTAAGLNQSPPAPLPNFTFGASTNNMAHATATSVEEWANGLSFNQNDGTFTMADHWMADTNMTPQAEFGLDESLLYQASFCTIDDTFTNLHGTRTDGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTM3</accession>
    <name>A0A7D5UTM3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g008250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549682.1">
        <property type="nucleotide sequence ID" value="XM_014694196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTM3"/>
    <dbReference type="GeneID" id="26239126"/>
    <dbReference type="KEGG" id="mbrn:26239126"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="414" mass="45364" checksum="D540F8B1BDB10CF6" modified="2021-02-10" version="1">MASRPRRSAATKANESISVHAKWADASERSERSTMTSRRSGRTSGAGASRDLPSSPDESVTVKTTSRSTRGANRRSDRFDGGEIVHGTRNRGGRKNYVIDSSPDEEEEEDAEGDDVEDADEDAEGDMEVDAEGDDIDAEGEEDAEGDIDMDAPVVSRTIRVSQPAPRSAAKVAASKMAIGEDEEDEDEDDDDELSDPVDSDEGEQTMGFGDETMADEDAEGEEIEVAGEDEEEEEEEEEDEAEEGDEDAEGEEVGNAEAESDGGTREGTPDLTKMTKRQRARFEEEPQEYMKLSDEVQVKKHFTAEELSMRRQEMARRRRNLSEKRNEEVKMETINKLLKKQAPKINRKAAAAAARADSPTEELYRPDPTLIRWVNSKNGSRVSVPADIMTGPAGQVFSKGGGLASGKMVEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTP8</accession>
    <name>A0A7D5UTP8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIP_2</name>
        <name evidence="6" type="ORF">G6M90_00g045270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544687.1">
        <property type="nucleotide sequence ID" value="XM_014689201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTP8"/>
    <dbReference type="GeneID" id="26242028"/>
    <dbReference type="KEGG" id="mbrn:26242028"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028832710" evidence="4">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="108"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="343" mass="37517" checksum="B4FEB39043ABA268" modified="2021-02-10" version="1">MLFKTALGFAAIAAAGAPIAADDSAKALETRWGARISNNDFANIRFYAQHSAAAYCNIGVPAGQQIACGNNACPLVARNRVKVVASVTGDLTGTGAYVAIDTFRREIVVSIRGSNNIRNYITNLIFSWTDCNFTKQCQVHAGFAQAWDEIKVAVNRAITNARRRYPQYAIVFTGHSLGGAVATIGAANLRRSGLWVNLYTYGSPRVGNDWFASWFSNVQGGQWRVTHEDDPVPRLPPIFSGYRHITPEYWLSGGNGGNTYKTDYTIANIKVCEGIASTQCNAGRDVTDINAHLYYFGAIASCAPSSLQLRDADAQDDPLPKDLNERLTDWSRKDQEFVKSENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU16</accession>
    <name>A0A7D5UU16_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mtr_2</name>
        <name evidence="9" type="ORF">G6M90_00g050840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545185.1">
        <property type="nucleotide sequence ID" value="XM_014689699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU16"/>
    <dbReference type="GeneID" id="26242526"/>
    <dbReference type="KEGG" id="mbrn:26242526"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF479">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="74"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="489" mass="51502" checksum="BEEC32CEBB5659B2" modified="2021-02-10" version="1">MAEQITSTPAPATATAAVKASADSGKPSAATPPAPSPSHPLGLADTDIFGETSEEMDQDRLKQIAAAGNAHFHRLGWKRLAVVTIVEAVALGALSLPAAYHTLGMFPGVFLTITLGSIAIFTSWLVGQVKLKYPETASYADAGRLLLGRFGYEVFGAALVLELVMVVGSHALTGSIALSDLNDGRTCSIVFSAVSAIILLILAIPPSFTEVAILGYIDFGSIVAAVGITIIATGIQARDGPGGLSGVGWSAWPKEGVTFSQAFVAVSNIIFAFSFAIGQFSFMDEMHTPTDYMKSIWASGLIQIAIYTLTGALCYAFIGPSVQSPALLSAGPLISKIAFGVALPVIFISGSINSTVALRYIHGRMFKNSVLRYIKTPRGWASWIGLVTVFTIVAWVIAEAIPIFSDLLSLASALFVSGFSFWIPAIMWFKLLCQGKWYSGRNLLISLGSIVAFVIGAVTLVAGTYSTIVDIIKETNDGSAHSPFACRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU35</accession>
    <name>A0A7D5UU35_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g041270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547473.2">
        <property type="nucleotide sequence ID" value="XM_014691987.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU35"/>
    <dbReference type="GeneID" id="26240036"/>
    <dbReference type="KEGG" id="mbrn:26240036"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="42586" checksum="060F2510BF519965" modified="2021-02-10" version="1">MSFNLSSCVPAPVCSDKTTKFTNLDSIVDISKYYGDSTKKDWVAQGEPASRDGSVLLTMPKNSVGTVLASTSYMWYGNVKAKFKTSRGRGVVTAFILLSDVKDEIDYEFVGVDLETAQTNYYFQGIPDYHNSGNISLSDTFHNFHDYEIRWTPDKIEWLVDGQVGRTKERKDTWNETSQSWMFPQTPARVQLSIWPGGASTNAKGTVDWAGGPMDWEAEDIKNVGYFYAAFSEVTMECYNAKSAPGTNNGKSYTFNSVTGTNDTVVDGKGDTVLGSFEGTGFNMMKDKASASQSADKPKNTAATIPGGSTGGTGQDHSGKSGSDSGSNSGGNSGGNSGGNSGGNSGSGNSGGSSSSGCETNTFNQDCASGSGSGSGNSDKGKNSGTRASASALAMIIAGCALFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUA9</accession>
    <name>A0A7D5UUA9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLD2</name>
        <name evidence="10" type="ORF">G6M90_00g047600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544878.1">
        <property type="nucleotide sequence ID" value="XM_014689392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUA9"/>
    <dbReference type="GeneID" id="26242219"/>
    <dbReference type="KEGG" id="mbrn:26242219"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="484" mass="53536" checksum="7B48284C166B38C3" modified="2021-02-10" version="1">MDDETRSRYESKAKDLRTELKAWESEWAQAHGGSKPGRQDIKDNPDIAQKYKDYNKARDILSGKQPPPAKSEPKPKKRQPDPILTETPLKRTKYAQTPSKQRTHDEDLMNTPAISRKLFSPAPVTSLGPTPQRDGRVLGLFDLLVEKELGTPSKKDTSKPSGTPGRSRGNVQSTPSKRTGSYDHESSTRLGRTPMSSSKRNVLNTFATPMKNRRGSLDAKTPSSVSKLQFDTPAFLKRHSLPAVDENAMFADPSPLRLPRKPLVRGLSEIVASLRKVEDDVLDDDDDLDALRAAENDDTDIRRPTSPSLGTRQASDPAAVSTPAIMEDSQRPALLGGFDDENMYDSPVEDAVDHNGNPLPVYKKKGQKRTTRKVNIKPTRIKRPENTPKDGNGDEDGEDVIPETQLINGPDADFADVASGSDFENEEPAKSTDKPAKATKKEGAVKKVARKVNELAHANFHRLKLRNNGAKGGPGYNSRFRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUB9</accession>
    <name>A0A7D5UUB9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g037980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547158.1">
        <property type="nucleotide sequence ID" value="XM_014691672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUB9"/>
    <dbReference type="GeneID" id="26239721"/>
    <dbReference type="KEGG" id="mbrn:26239721"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="121" mass="13095" checksum="D804C78A443C7410" modified="2021-02-10" version="1">MQALGSVSFKVEGCTGEAARRVVPETVNWSSRLLTWPGLWTFNVAHQTSMPARTHARTTEDANLVQLDAASRRPARLRAGTVRSRRKVLDPETTAASVDARAAKLPSLFCTPGGGDGVHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUL4</accession>
    <name>A0A7D5UUL4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lethal(2) giant larvae SRO7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SRO7</name>
        <name evidence="6" type="ORF">G6M90_00g044000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547735.1">
        <property type="nucleotide sequence ID" value="XM_014692249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUL4"/>
    <dbReference type="GeneID" id="26240298"/>
    <dbReference type="KEGG" id="mbrn:26240298"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="510"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="896"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="979" mass="107234" checksum="BA6C9038551B6679" modified="2021-02-10" version="1">MSSFLRSKQAGIQNDLSASIRPELFMPDEQARYGINSQIGCLGYDPVQSLLAIGTKESRFGPGKIYVFGQRRVQKILQPPRATSFHSVQFSANRLVSLDSKNELGVWDLDTGARVAAQVIAGTAVALITDPMLDWAFIGLQNGDILAYDLDRRTMTRSFRLPNFWHQKDPAAARAATLVCLSMHPRDVGKLMIGYSHGAVIYSFKQNKPINFLEYTLPAGAPGGNGVGVDTMRRPRLTHAVWHPSGTFVATAHEDGSLVLWDYREQRVITARNLKDTGVEKPVPNSTAPSSSGRYTKIAWCCKENCDDTGLLIAGGESPDTSPRNFTFIELGITPMYATSSWQVLADYFKGKRQISISLPPGAQAVDFLLIPRSSPHFAGAQDPIAIMALVSSGELITMSFPSGYQISPTNQLHPSTFFVHPFVTKVNVSSLERPRWLTMEEKRDQGELLVTGGAKGPRPKKRFEERTIIQAAHGDSTIHIWDSGHADEIENDRQLQIDVARSLDRYDDIDITAMNMSSATGEFAVGTRTGEAIVYRWGGNRFYGRDNPKQLDPNPKGLTDISSRAEPTLKEGLQPSILYEMMQGPITAIQVSNVGFVAVGSELGFLTLIDLRGPQIFYQAPMTDFAKREKRSSFFKRDHHHQARDEPQKEWPVVIEFGVMTLDEDKYSSICCFVGTNLGKVITFKLLPAAGGAYTAQLAGVVAFDGPIVSLSPINAQTGKPALASAATVGSLREGKRVDGALVAVTQKEVRVFRPANSKGASRDFDDVVCHAASVAELELQGFAVVAFFDDQTARAYSIPGLKDLGQAQLSMIDPTKPAFVAQTGDVFGWTGPSEMTVIHVWGTGKPLQQSPDTLINPELQCPPRPTISNMQWISGTQYVSPLDLDLLVGGPDRPPSKRMQDAAAAERRAGAGGLASQESWGAYLTRQVNERTERLGVVNEGMDSLQQQSQGWADDVTKFVNQQKRNLVMGSIKSKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUN3</accession>
    <name>A0A7D5UUN3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled receptor GPR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPR1</name>
        <name evidence="9" type="ORF">G6M90_00g046030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544730.2">
        <property type="nucleotide sequence ID" value="XM_014689244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUN3"/>
    <dbReference type="GeneID" id="26242071"/>
    <dbReference type="KEGG" id="mbrn:26242071"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="417"/>
            <end position="486"/>
        </location>
    </feature>
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        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
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        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="564" mass="63329" checksum="9FDCAE521AF2694C" modified="2021-02-10" version="1">MVSGRDVKHPVRHEGIAANAGSTIPSLEDTFPGNLTHEHLLELHVAAMVVGFTSLLATLVAVAFFIQMRRRFRHDLILLLILSDMLATFWLVLLPAIELAHGRIPSNSTLCQISGFFLSVGIEACDLTVLLIAVHTALYIFRGRSGLYPYRFFAYALVATGSLMLTSLAFINNPGFVNSGAYCYFPARPTWTLRFLSWVPRYVVCAVMIFIYTCIYIYMRCIMIKVNEPNKRRKVDEPFFSRLQQLPRRGSVPPTPPIAYHGLIPPTPPIDNTQPEYGWNRGARYSQHGGSRKGSLVGNGGGQPLLKPPVSATSQTDCEERSLIVAKDPFKDYPPSVHCRNGSKDEATTLSPTDRPAPTQHIIGCSCMVCTGAGTPHIPPPLNIELRLQDGTGEAELPTNFVLSPTTLIETGLPNPRHKIRRQLRRKFIYPVFYILGWMAPFAAHVSQADRTGRPFPLVLAGLMSLCIQGLVDSVVFLMLEKPWRHRKRPACFMPLRKCSTMKNSSARVGRTREEMLVEGRLAKTRRDREEEDQRRQPQRLETNKREWWDAKLPGIDESGDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWJ7</accession>
    <name>A0A7D5UWJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g062980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542584.1">
        <property type="nucleotide sequence ID" value="XM_014687098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWJ7"/>
    <dbReference type="GeneID" id="26244533"/>
    <dbReference type="KEGG" id="mbrn:26244533"/>
    <dbReference type="OrthoDB" id="5427070at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="146" mass="16590" checksum="4175CE7482446C56" modified="2021-02-10" version="1">MAASSSSMLSLVKALFVPAVISLIIFLFLTFVIAPIWRRYRNRYSQYLPVESISNHTSGLRHRIVNRFSRFTLPSTWSRNRGSVDNPSADDFLEDGEELGDVDEQTLNAIQRLHSHLGSGLDSNRRLSRDLEEGFMDDSDEEQARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWN5</accession>
    <name>A0A7D5UWN5_9HYPO</name>
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        <submittedName>
            <fullName evidence="11">Hexose transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KHT2</name>
        <name evidence="11" type="ORF">G6M90_00g055010</name>
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    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68855.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685418.1"/>
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    <dbReference type="GeneID" id="26246210"/>
    <dbReference type="KEGG" id="mbrn:26246210"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS_HXT"/>
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    </dbReference>
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        <property type="entry name" value="Hexose transporter Hxt3p"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="46"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="576" mass="63092" checksum="0A9B7C9B15E932E1" modified="2021-02-10" version="1">MKGFMTVRFDHVNPASEKSNQNDVRSSLAGLDYSPLPRLTMRSLAMGCLVSMGGLIFGYDTGQISGFLEMPDFLERFGMTNPDNGQKYFSAVRSGLIVSLLSIGTLIGALAAAPVADRIGRKPSVSIWCLVTSVGFVVQIAAVTAWYQVMIGRFIAGLGVGALSLLVPMYQAETAPPWIRGAMVCAYQLFITMGIFLAATFNYGTVTHHGGDSASWRVVIGLGWVWTLVLGLGILGFPETPRFDFRHGRADRAADTICKVYGAGTNHWAVYTQLEEIEAKLRAEDTVKLGPVREFAAMFAAPKMARRIALGVALQMFQQLTGANYFFYYGTTVFRSVQINSFVTQIILNTINFLVTFIGLYIVEHFGRRKSLMAGSAWMFACFIVFATVGHFRFDREDPQRTPAEGIVLIVFACLFILGFATTWGPMVWAIQAELFPSRFRAKAMALGTASNWIWNFCIGFFSTFIFNAIDFQYGYVFAACNVVGGLIVFFFVVEGQGRTLEEIDTMYLEGVTPWKSAAWVPPPAEHMARIRREAGADLETAAAAAAPGPRDGGAGGARTEGKETGDEAPHHEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXC0</accession>
    <name>A0A7D5UXC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g056930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986767.1">
        <property type="nucleotide sequence ID" value="XM_066130629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXC0"/>
    <dbReference type="GeneID" id="90967807"/>
    <dbReference type="KEGG" id="mbrn:90967807"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8620" checksum="4642AA303A25E535" modified="2021-02-10" version="1">MAHLNVKPDPAYLKHQAMQKTRHHFFRWTPRTARITFMYVAVVPAIFGYVAYKTDGLYNFRAKRRGDTIYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXD0</accession>
    <name>A0A7D5UXD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 13">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">aglA</name>
        <name evidence="16" type="ORF">G6M90_00g066220</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 13"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540151.2">
        <property type="nucleotide sequence ID" value="XM_014684665.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXD0"/>
    <dbReference type="GeneID" id="26246960"/>
    <dbReference type="KEGG" id="mbrn:26246960"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000177">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF91">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="15">
        <location>
            <begin position="322"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="14">
        <location>
            <begin position="412"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI69295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="535" mass="58497" checksum="E838E9DC3B8972BB" modified="2021-02-10" version="1">MKAQVAMAATGLASSAAASSINILPTPPMGFNNWARFMTNINESIFIDAGVAMSNNGLRTAGYNRLNLDDAWSLLQRDANGSMVADPAKFPSSLPWLTDWMRSNGFKPGIYTDAGSLSCGGYPGALDHEKRDLQDFLRWGFDYLKMDGCNLPNDEEETYHEMYSRWASLLSYPKEVAMVFSNSAPAYFSNQKNLTDWYRAIGWASDYGQLARHSADIVTYPNGNGWKSIMFNYGQNLRLARFQRPGFFNDPDFLIPDHPSLTMQEKKSQFALWCSMSSPLLISADIPSLPKETIDFLTNPGLIAVDQDKLAQQATLVSRNATWDVLTRTLANGDRLLTVLNRGDSAASVHIPLERAGIDFGAIGDGNVTVQDLWTGRVTYLLPGEAPLTIENIPAHGTAVYRLQSISPITPTGAIFNTNSLKCLTDSPSGNVTWDACQGTDAQVWAVHKEDGRVSSLLRPKDCIVPVDGVVKTTSGCVRHHTNPWTYKSSGNLVDNKSGNCLTENIDGTAIAEGCGYLLNQQVLALPAGVPVIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXP5</accession>
    <name>A0A7D5UXP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g059030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544476.1">
        <property type="nucleotide sequence ID" value="XM_014688990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXP5"/>
    <dbReference type="GeneID" id="26242888"/>
    <dbReference type="KEGG" id="mbrn:26242888"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028829578" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="3">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="451" mass="49190" checksum="66DF166408CB37D2" modified="2021-02-10" version="1">MRSLKSLRGNPFRLGSLLALACLTSAHSWIEYAYVLAPNGTMVGNIGYPRGYQPRSTSGWTDKIPQWILPENGTAFYTGEEILNKYPFEQNPKQPVLEAAPGDHIALLHLENGHVTLPQTQANKPKNRGTIYLYGTSEPSENEKLFDVHLLWNKDGTGGNQKGVLLATRNYDDGRCFQPNTADITNQRVAEWKDDGAQNSQELLCHSDLKLPDNLKPGSFYTIYWYWDWPALNPAKINMDKTADGRFPWAGSFMRGDKVPNGWTMDTIARNESYSSVIDIKIVEKPKGFAGKDAGKEAWVSKQNVYSMGVQDQMANNFQVNVDGLENSGTGSAPTSAPASAPASAPASAPAPTGSSPAASSDAGGVATVTQYVTVPPTTLITTVFKTVGGGYKKVRRSEPAPEQSMLRLTNHGTDEAPFTTASPTDTPDQHSAAKQVSSAAPYDRRRARWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXY7</accession>
    <name>A0A7D5UXY7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540943.2">
        <property type="nucleotide sequence ID" value="XM_014685457.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXY7"/>
    <dbReference type="GeneID" id="26246249"/>
    <dbReference type="KEGG" id="mbrn:26246249"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="141" mass="15623" checksum="C31E077DF60D939C" modified="2021-02-10" version="1">MSPESTRGINDELTSAQTGDPSKRRARQAQDNADMPDLASLQSASFSANEISAVTPDYDKYGPDDQVMLERGKRCTVVGPSTYPRKWQRISDCEDAAWAGVADDEALNHAQSLHIFASMPLSIERFLAERSNLTDNEYTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY06</accession>
    <name>A0A7D5UY06_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ylo-1</name>
        <name evidence="7" type="ORF">G6M90_00g063740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542511.1">
        <property type="nucleotide sequence ID" value="XM_014687025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY06"/>
    <dbReference type="GeneID" id="26244460"/>
    <dbReference type="KEGG" id="mbrn:26244460"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="517" mass="57200" checksum="D3AE5B8E6B97F3DA" modified="2021-02-10" version="1">MSYSSEAQVDEAFNAVSNTFKSNATKPLEWRIRQLRKTWWMLEDNRERIVTALNQDLNKHRQETLPVDVAGIQNACLEALANIKEWTKDEKPRRTDPFNLLGGARIRKEPKGVTLIISAWNYPFMELFEPMLSAIAAGCTTILKPSELAPASERLIAEIVPKYLDQGAIRVVTAGPKQMNYLLERKWDHIFFTGSTAVGKIIYAKAAPNLTTVTLELGGRGPAIVTPSADIDLAAKRIANAKFMNAGQICVGVNHVFVDPSVKQKFIAALSKYFDEYRSGQSRQPAYATRIVNERHYKRLDNLLEKTQGKIVYGGDRNPETRFFAPTIVDGVSTDDSLLSEELFGPILPILDATLEQAINYTVQHDHPLALYGFTSSQADKDKILRLTNSGGVCFNDAILHMLVKDAPFGGVGASGMGAYHGPFGFKEFTHLRTVVNVPAWMELLLKVRYAPYTDKKAAAMVRSTGAKTSVPFDRNGNDVTSLAGLLTKSAIAVLFFALLKWKGWSVTDLIASVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ78</accession>
    <name>A0A7D5UZ78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SCP2_0</name>
        <name evidence="12" type="ORF">G6M90_00g072200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545843.1">
        <property type="nucleotide sequence ID" value="XM_014690357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ78"/>
    <dbReference type="GeneID" id="26241876"/>
    <dbReference type="KEGG" id="mbrn:26241876"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="266"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="459" mass="49251" checksum="4EE926D7D86C7B67" modified="2021-02-10" version="1">MPAKQKSPVYVLGVGMTKFIKPRGLVDYTELGFEAGIKALLDAQINYDDVDQGVACYCYGDSTCGQRVFYQFGMTKIPVYNVNNNCSTGSTGLAMARTFIASGAANCVMVVGFEKMMAGSLQSFWNDRENPIGTTVNMMVETRGFEPAPGAAQMFGNAGREYIEKYGAKPEDFAEIARVNHAHSPKNPYSQFQQVYTLDQIMQAPKIFDPLTKLQCCPTSDGGAAAILVSQEFLDARPHLKAQAVEVAGQCLATDAPSLFSRSSIDLMGYEMTQHAVKTAMGEAGITPKDVQVVELHDCFSANEMVVIDALGLSEKGKAHELVRRGDITYGGKYVINPSGGLISKGHPLGATGIAQCAELVWHLRGWANNRAAPNTTYCLQHNLGLGGAVVVTVYRRADGKAAPELDNAAVGKSNGLGYNPAVEAKGFTKDQAAAVRSKTASSDWALSDTQEKVLQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZI2</accession>
    <name>A0A7D5UZI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g055220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540885.1">
        <property type="nucleotide sequence ID" value="XM_014685399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZI2"/>
    <dbReference type="GeneID" id="26246191"/>
    <dbReference type="KEGG" id="mbrn:26246191"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="65371" checksum="738E794AA09E636D" modified="2021-02-10" version="1">MADTRRSSAQRRNPAVRIVADLIKNASIFRELRQMERRWLPTELPEYETWRSDDPEPSAGALAHFVKIYRDRIYFQPLPLFDPQCLKDRLHLFPYYLRWSFLALALHFSTHEFYAGNESEATALYTTSARGVVQELSTEGVVKTEVLQSLCLLALCEILDGEYARSWMTMGAASRLESLRLSQSRHMPSAPNSDTISRCHWSIFVLENMFTPSLVLPARKPGRPKFPSSPDAPAPMASLTVASSHSHCPDLSSNVQQDGSSPDLGINANSLQLISIWGDIVAYLQDVRYGLSDMPWLNTSRHAKLEVSFYEFEVRVSSLHMLRHASFPDRLMAEIDDKREYWMPWLTMEILHHASKAALNNPFVQLFALRGSNAKAQPGSYLQKTIDQALFNYEWVARIVQMIQGASFELCDPLIGSAVAATATIPWIFQFARDETVAVKAGQNLELFETFLDGLSLRWPHLGIKLQTLRELRSRSRSEDEGGATSTTIRFQPDLVWRLLCAGFPPEMGAPDESSTTGHGHSNATLHVTTQYVHPLMDPPPRRPMDDSNMEIFFDASFDGFDAQFPEGFFSQTLLGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZR0</accession>
    <name>A0A7D5UZR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g066730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539540.1">
        <property type="nucleotide sequence ID" value="XM_014684054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZR0"/>
    <dbReference type="GeneID" id="26247623"/>
    <dbReference type="KEGG" id="mbrn:26247623"/>
    <dbReference type="OrthoDB" id="4865290at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045564">
        <property type="entry name" value="DUF5910"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19287">
        <property type="entry name" value="DUF5910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028897281" evidence="2">
        <location>
            <begin position="21"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="788" mass="85475" checksum="CA49BF243BE9BA82" modified="2021-02-10" version="1">MTHKVFGWLIALALSEGVWGGPTQLPSGSRITIGYRRVHPNQAAKYKEAGTLTDDPITGHTQIGEGVYLTAGYGQWEGHAGDVDCAVTADEEEFRTVPKVILPDEQLLDTTHEEIDAYIKSQDSSWDPLKTIRISHIPKYGDGTVAQMAIPQALLNSRGGSLQIQVDCEDAQGPTVDYGQWENTKGDASIMPARADSNKIFDLSNELDASRDLVEQVSSPEHIAQLELRATNAMYTAREGVRHYVKTAEECKGDSVLKGLCKDQIKYYLQDRQAYARFLIRAAERSFEMLTTPLNAVIDDAARQRAIQALQEWATRLQRQVDARAKNLEALKKGEPVKGLDDPKERDIEKTALKRELKAMKKKLSKLVDKAATFGAKAEQGSVPPKEGQKQTKLQQLREWLQKNKNRFFPSGDGDKDEYEPTAGKDDKDPSRREACVKEQYSGDASQAFETAYTVIEERDDEDRICPEGQEGAAACAAAKFKGDGQAAFSDAYQLLKAIDSLELVCPPPDTAGDAPGGSSPAADLAGLRSEGWRLFVQQALGLGYTRERLVHILDRGVGLLQLDNPRLYDLLRQHPAAFNVLLGLRRDGVRLSSCLPDGRLQRRANGAGQSSDHCEIVRAMTSGKQADNATPNDDGKQPPTKQEPPKEPENKFHDQVKKLQHVSSGDGSWTGGILGAFFAGPLFAGSILATSPEVVALIGELGASLGLAGTAAGSFSESSAVGGALSAVRSAAARSVGSILRRTIGRLNYLAHRAINPVVRRIVSDAVRAGTRAAERAPLLGAGSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZZ2</accession>
    <name>A0A7D5UZZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">chit33_1</name>
        <name evidence="17" type="ORF">G6M90_00g073410</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545724.1">
        <property type="nucleotide sequence ID" value="XM_014690238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZZ2"/>
    <dbReference type="GeneID" id="26241757"/>
    <dbReference type="KEGG" id="mbrn:26241757"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028856818" description="chitinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="31"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI71210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="35010" checksum="F4F44EDE71E3B762" modified="2021-02-10" version="1">MSSFFWSLASAASLLAALPSALAGFNGGSHKNIAVYWGQNSFGQGSGPNVQQGLAHYCENADMGIIPIAFMNGISPPITNFANAGDKCDKFPDNSNLLKCPEIEKDIKTCQTKFKKTIVLSLGGATYSQGGWSSTRDAEKAAQSVWDMFGPVPSGSKVDRPFGSAVVDGFDFDFESTTNNLPAFGAKLRSLMDGGGGKKLYLTAAPQCVFPDAAVGSALNAVAFDFVMIQFYNNWCGVSNFKPGSDTQDAFNFNVWDKWAKGSKNPNVKLLLGIPANKGAGGGYTNGEKLKAVIAYSKKFTSFGGVMMWDMSQLYANEGFLGEVVSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0P4</accession>
    <name>A0A7D5V0P4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase ATR9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ATR9</name>
        <name evidence="4" type="ORF">G6M90_00g066860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539552.1">
        <property type="nucleotide sequence ID" value="XM_014684066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0P4"/>
    <dbReference type="GeneID" id="26247635"/>
    <dbReference type="KEGG" id="mbrn:26247635"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="28181" checksum="890D6764D776A164" modified="2021-02-10" version="1">MANFKYIHKLRNARIVIFGATSGFGFAVAEAAIEHGANVILCGSNQQRLDGATKRLEASYSECTRGQITTAVCDLADVDNLEAQLQDMFNTITDNAVSKIDHIVFTADDSHAAPPVSKTTPNDIYLSLRLRVYSSTILAKVVAANDFLQHSPDASVTLTNGVNGHKPVKGWVVPGMASTALEGLVRGLAVDLAPVRVNLVSAGPVATELLAKLPQEYIDMYEAETLTKRLGRPEDVAEAYLYAMKDGSATGSIIFSDGGRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0X9</accession>
    <name>A0A7D5V0X9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g090730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541731.1">
        <property type="nucleotide sequence ID" value="XM_014686245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0X9"/>
    <dbReference type="GeneID" id="26245594"/>
    <dbReference type="KEGG" id="mbrn:26245594"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="70"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="467" mass="54831" checksum="F23F07A740052A5D" modified="2021-02-10" version="1">MEPRMRFDDVAWEESENIESAWVKDILKEESQRAIGNFIVKHRQGVPTELCDPKAGAFNVLFRMKFQDGGSAVIRFTKPGCTMFPEEKIQNEVATIRYIQDNTSIPVPFILHWGPREESPLGLGPFIIMEYINHETDVCKVLNIPELHWEDRPRLNPHINLGKLEMLYYQLADVLLQLSKLEFPYIGSLEEVKEFESEARRRPLSIHMNELIRLGTLPRNKLPSGTFTSSFDYFEALSQLHIDHLAHQRNDAVDSETDCRRKYVARQLFRKLVRQRRLLSKAHADGPFKLWCDDLRPSNVLLDANMQIVGVVDWEFTYAAPVEFSFSPPWWLLLEQPEYWPEGVENWKEIYDSRLKTFLKAMTDVEDAAIASGRLDEAQRLSPRMKESWDSGEFWVIYAARKNFAFDSIFWRELDPRFFGNPGVAQEDSWRKRLDMLDELERSCMEELVERKMKEMETRVLAWEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V126</accession>
    <name>A0A7D5V126_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g086850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987345.1">
        <property type="nucleotide sequence ID" value="XM_066131297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V126"/>
    <dbReference type="GeneID" id="90968090"/>
    <dbReference type="KEGG" id="mbrn:90968090"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="40" mass="4486" checksum="FF35CFF7CA4E580C" modified="2021-02-10" version="1">MAGGSTTTYIAWDPAPFRRRHNNTAQQPGNWVELDRVIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V155</accession>
    <name>A0A7D5V155_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase vrtI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vrtI_2</name>
        <name evidence="5" type="ORF">G6M90_00g082500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543479.1">
        <property type="nucleotide sequence ID" value="XM_014687993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V155"/>
    <dbReference type="GeneID" id="26243656"/>
    <dbReference type="KEGG" id="mbrn:26243656"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000152">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="184"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="362" mass="39787" checksum="E0098A1B3C99DCDD" modified="2021-02-10" version="1">MAPALDPPQTIDWMGKKVPVWSMQTINYGLLLSQDPSEIDKVVNACLEEGYFYLDLQGIDGRRMLADHQETLKLMKRFFAAPLEAKNEFGLISSHLGYEPVGSRTGVGAGTKDGYEMLKVSRDEIQRDSPKIPAPVKNSGDLQILENAIGSCNTVTKVILSALSTGLHLTGAGRFENSHRNERPSTTTLSMMHYLPSDLAGENRIGHQKHTDISTLTLLFSEQWGLQIRPPGACGAREMGFVAPKPGCAFVHVGDSLRFASGMKFQSCIHRVVPFDPSEHRYSIAYFLRAEDDTMFVDSEGRAITAGQWHDEKFKAFTDPELWQAMAPKSMILGGMKEDGEDEPVAARVADARAQAAVSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V251</accession>
    <name>A0A7D5V251_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g088030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542312.1">
        <property type="nucleotide sequence ID" value="XM_014686826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V251"/>
    <dbReference type="GeneID" id="26244826"/>
    <dbReference type="KEGG" id="mbrn:26244826"/>
    <dbReference type="OrthoDB" id="5374349at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="33150" checksum="2CC87BA377BD4412" modified="2021-02-10" version="1">MASTASDFQKLIADARERKKNSALADRIFSRDRRQSAPSKLKPTPGGSLASRVGVKKQRAPAAAAAAAASNTRRASLPAGNVNGEWTHDLHDSVNGVPAKGGSLSSRITVPGAKNGNTATKRAASRKAKLAAAVDKMDTDQVNVVTPSFQATSGMGLTIRGLAGPYALLGQNFAPGTTAADIESAMTPVGGEMVSCKIVKTKPFLIAEMVFVSREGGERVIETFNNKTADGRVIQIYPKVGGHQASATTNEPPANAPSGPKSSKASTRDQVVDGSMGFPDPMDTNGSTNWAGNNRLYSDRMVAGNKRGRGFQRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2B3</accession>
    <name>A0A7D5V2B3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g084960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987434.1">
        <property type="nucleotide sequence ID" value="XM_066131262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2B3"/>
    <dbReference type="GeneID" id="26246044"/>
    <dbReference type="KEGG" id="mbrn:26246044"/>
    <dbReference type="OrthoDB" id="4875122at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028873947" evidence="1">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="290" mass="30471" checksum="73B2EB2E45FF9A82" modified="2021-02-10" version="1">MKLSLLLVATTAAAAAVRWANDDELAVMNANRGKVGTALAMPSALEMQAMEVERMFNITPGLLANSTHQAQDRRGEEQALAANQFIRAGGFAMFIAFTSDAGGALGAVWSDCYGAATRDGTATGKECGDKVIAALVKASYSFVMGGAGYAAVLIQGQADPNQPVYELQNQLPPDSEHGVQMRRSADQECANHNGDFTGLYGVNFHLGSHIGAKLSGYAPCGTSVSTPDEIAQGSFGYQLNRAAGDNGAARIQFYTVQDGSRGNVMGGAIVYETRVTDTCPEYISFDGCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V325</accession>
    <name>A0A7D5V325_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor eIF-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SUI1</name>
        <name evidence="7" type="ORF">G6M90_00g089490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541611.1">
        <property type="nucleotide sequence ID" value="XM_014686125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V325"/>
    <dbReference type="GeneID" id="26245474"/>
    <dbReference type="KEGG" id="mbrn:26245474"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="114" mass="13052" checksum="BDD5D11D41D84B83" modified="2021-02-10" version="1">MSIENLKTFDPFAEADEDTGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVNDTEMGEVIQLQGDQRKDVQEFLVDKKDGLELDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V340</accession>
    <name>A0A7D5V340_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541388.1">
        <property type="nucleotide sequence ID" value="XM_014685902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V340"/>
    <dbReference type="GeneID" id="26245638"/>
    <dbReference type="KEGG" id="mbrn:26245638"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd07739">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF14">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="288" mass="32109" checksum="2B6DDC896F624977" modified="2021-02-10" version="1">MSLRAAVYIAPPVPFKNPGKGSGGGLWSPISCTLIYSATHAVLVDTPITIAQTKELIAWIRRIAPNRALSYIYITHGHGDHFFGIPLLVQEFPEAKPVATAGTVQHMKQQVEENVFRFQWDSRFPGEIQQPFVLAEPLPRDNKFTLNQWELQAVEVGHSDTYDSTVLWVPALRLAVCGDVVYGQVHQMLMETNTPAKRAEWIRAVEKVEALDPLHVVPGHCQEGEILGRWHLDKTKEYIRAFEDVLKGNPKSARDVVGAMTKRYPDRFNVGAIILGAQAAVQAAQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3W0</accession>
    <name>A0A7D5V3W0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Signaling mucin MSB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g085480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541105.1">
        <property type="nucleotide sequence ID" value="XM_014685619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3W0"/>
    <dbReference type="GeneID" id="26246094"/>
    <dbReference type="KEGG" id="mbrn:26246094"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028801819" description="Signaling mucin MSB2" evidence="3">
        <location>
            <begin position="22"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="83194" checksum="4CD6CE23091B1399" modified="2021-02-10" version="1">MYAKSLALASAVALAASVVAAQPEHPRIYFPREIKREYHNSTITSKVSSSTPHVTTTTTTTSSSSTRRDLLSDLISEILGSDSPQKSSTTEKPPVPTVAVDSTPTPGGSSGSGLPKETVLPTSKINESKTSSSARARPSTEPGIVIGPTGIVSSTSEPKTTVEPSKKTTVDSPKVTSVDASASNSTVPETNPPTPATAKDPIPTGEPPKQTSVDPAVTNNTTPETKPTTPITVDKPTKTGEPATKSTTVDTLVGNNTVSDTTPTTTSGGILDPIGTLLSSLLPGSSSASTSASTKTNSPEQTGTSISSTSTSSPEQPIPQNSTTQAAPTTEPSTGLLPSLTSLLPLPGSTTTTSGSGSLPNATSTEVPVTATSSSSGSIITNSPTATTTDVPIGNSTSTSSGTVSSAPTSAPTATDVPITNGTISEPPTGTATSVPTTPISVPNDNSTVIVGPTTTSNIDTVVPTTKSDFTSTVAPSTTTGVEVTSIRPTATLPNTDNWLPTTVIIEPTTFSFSSPTSNPTETSLQALPSTVPRVIRPDTDGDKKPPVLEGAVPIHIAFNYTLHYLFLANDTMAASQIFKYLPDVLSSACGLPADQLPVTELAPYNTLATRGFVTTLARMNYTKALLPALAANLKTPSSAIYQNRDPVLHQFASYIDSTISPTGELNDGSSTDNGGPGSGNDGNSNNSNGNGNDAFGSGNQGDQTPKQKATTAGIAVAAVGFCALYGAAMFIVARRYKRKRQGHRRASSIVSGQGSPEMRYNDNASPALMGGALLSRDGSTYGGTGGRDSHASGGHSGRTANISAPVATENSLGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4B9</accession>
    <name>A0A7D5V4B9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NRL3</name>
        <name evidence="4" type="ORF">G6M90_00g112170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987840.1">
        <property type="nucleotide sequence ID" value="XM_066131852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4B9"/>
    <dbReference type="GeneID" id="26246881"/>
    <dbReference type="KEGG" id="mbrn:26246881"/>
    <dbReference type="OrthoDB" id="4940526at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="41764" checksum="468CB5C5F81424DB" modified="2021-02-10" version="1">MPKDTKATIKVAAVQASPIFLDKCATTEKVCALIRRAGSQSAQIIGFPETFIPGYPGWVELLPLHTDQAASLFLKLFNESVEVPGPETTAIGAACKEASMYAVVGVNERRAGTTGTLFNTSLFFGPDGSILHKHQKYVPTVGERLVHAPGQTGSRASVMTEFGVLSSLICGENGNPLFQYAVGLDYPVIHVASWPGHFGEGMTVDGAINVFGPAVASSVGCFVVHAVGVVGDDAIEVYGTDEKSRRFLKEQQKQSRACVMGPGGRILAKGSEGEELVFADVCVDALVKAKYGLARNNDKLLSVAEGAAEAIYSVHNTSFKYGPSCRISGKFYGRLLDFVADVIRVDYAFVFELRSGGRFRRFMLPRDEIIPSGEETFAGVKYILQNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4F3</accession>
    <name>A0A7D5V4F3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyamine N-acetyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PAA1</name>
        <name evidence="4" type="ORF">G6M90_00g112730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540340.1">
        <property type="nucleotide sequence ID" value="XM_014684854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4F3"/>
    <dbReference type="GeneID" id="26246934"/>
    <dbReference type="KEGG" id="mbrn:26246934"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="65"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="200" mass="22062" checksum="295F1622DF52B9DB" modified="2021-02-10" version="1">MTAYIRPLSSLDLDRCAALESAAFPPSEAATYEKIDYRLSSCPELCYGLFLRNSDAAAPDPSTVRVLSSAEAQDKDGILVAHTIATKARATLIVDQDMDYPKDWKTNPRVVADAGHQPSGTSIALHSLAVSPDYQRQGLGKLLMGKYIEQVKKLDGVERISILTYERLVPYYEKLGFKNHGKSAATYAGVSWYDLTYDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4F5</accession>
    <name>A0A7D5V4F5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SIL1</name>
        <name evidence="10" type="ORF">G6M90_00g098710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with KAR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546475.1">
        <property type="nucleotide sequence ID" value="XM_014690989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4F5"/>
    <dbReference type="GeneID" id="26240898"/>
    <dbReference type="KEGG" id="mbrn:26240898"/>
    <dbReference type="OrthoDB" id="448649at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028946181" description="Nucleotide exchange factor SIL1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="44211" checksum="F0FECE08E9CBF202" modified="2021-02-10" version="1">MLALLFGLILCIFSAPSIADHSDSSNVPKPDLICHTSNPDECYPRVFQPTEEFQIVHDDQELPKGLHVRLNIWTGLKEAKINVPDEIDPSLEGMPVDQAVVIVDHEEQLGAPKIPKGAPEYEPVGKVKGPQHESAALVEGLNMLKSGTSKNNQAFDDALETLEDLSHDMYYGLNIAEDTEAMEALLCLMSGQSAPSTNGAVPHDQQAASILAGVFQNNPAALKQVTGFWPQLLVESRCPNTGKSLRQSLYSSVEPSRNGEGANAQQAAARVKPKVSVINGLIKDGSIRTHFLREGGMESLLKVLIPEDKAWAGAQRKVGQLVLDNFLDENTGATLGEWPYLPKLGDELCQTEESGTAEGCWDYHVERIMKSSKASKEDWSWQLNDRLAAARQEQSNERKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4W7</accession>
    <name>A0A7D5V4W7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">eth-1</name>
        <name evidence="16" type="ORF">G6M90_00g102360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546110.1">
        <property type="nucleotide sequence ID" value="XM_014690624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4W7"/>
    <dbReference type="GeneID" id="26240533"/>
    <dbReference type="KEGG" id="mbrn:26240533"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="128"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="250"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI72872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="394" mass="43020" checksum="D9C3D0A99C33DD07" modified="2021-02-10" version="1">MPGVNGTNGSSPQGTFLFTSESVGEGHPDKIADQVSDAILDACLAEDPLSKVACETATKTGMIMVFGEITTKAKLDYQKIVRDAVRDIGYDHSEKGFDYKTLNLLVAIEQQSPDIAQGLHYEEALEKLGAGDQGIMFGYATDETPELFPLTLQLAHKLNAAMSAARRDGSLPWLRPDTKTQVTVEYKHDHGAVVPVRVHTVVVSAQHSADITTEELRKQILENIIKKTIPAKYLDDNTVYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVARWIAKSLVNAGLARRALVQLSYAIGVAEPLSIYVDTYGTSEKTSDQLVEIIRNNFDLRPGVIVRELNLDRPIYLQTAKNGHFGTNQSFSWEQPKQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YML7</accession>
    <name>A0A7D5YML7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g004210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542073.1">
        <property type="nucleotide sequence ID" value="XM_014686587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YML7"/>
    <dbReference type="GeneID" id="26245104"/>
    <dbReference type="KEGG" id="mbrn:26245104"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="545" mass="55452" checksum="83C34BC00CE5141E" modified="2021-02-10" version="1">MTKPSHGSSLLQARDSRSHSHSHSFFHRFRHRPLHAHDPEQQSFGDDAASDNGFGNHLGANVELDSSNNALAKRDASETSQPVAVNAVGDEQTSLVTHVRQTISLVQYVDPWGSTYETKTIYSPPNTVVVDPKTGETIDISSGPESTVALPGPTPSGSTYSSSSLDSATPTSLSPTLTSTPSSATVKPAYPSVGDIRNSTSSAFPSNSSFATPSNSSSIYKLISTSVPISTADSSTTDSSTTSETKSTSTSAHSTHLTSSSSFLTSSSFSSSVSSSSSSSSSSSSSPSSSPSTSSSSATTTAPGNGYGTITVPGSLPTTQSEAGSSSGDSLTPQQKQVIGGVVGAVAGVAVIGLLLMLFLRWKKRKGSSTILDSQSGGATSRTLGDGTSGDSGSGGAMAERAAAPGAVAATLASLTGKRAPQTSHSADSGERGFYRVSGRKLPSVLHSGGDGYSDPRGSATSGSSDYHRGSQAFAPTSAGKGQFALGVPMRPISGVPIIRSGPARIPITQNPFADPPASPNNLSTRTLGSRESPRASGSKFQEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNE1</accession>
    <name>A0A7D5YNE1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-nitrophenylphosphatase</fullName>
            <ecNumber evidence="3">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pho2</name>
        <name evidence="8" type="ORF">G6M90_00g015780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548950.1">
        <property type="nucleotide sequence ID" value="XM_014693464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNE1"/>
    <dbReference type="GeneID" id="26238394"/>
    <dbReference type="KEGG" id="mbrn:26238394"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="326" mass="35580" checksum="C29A3316E542F22A" modified="2021-02-10" version="1">MASSPKYLTGDKASINEFIDKFDTFLFDCDGVLWSGDHVFDRVPETIMMLKARGSSPLTSHPSCAFNSYSSPSGKRTVFVTNNSTKSREDYLQKISNLHIPCEKEDVFGSSYSAAVYISRILKLPPGKTKVFAIGEAGVEKELAAEGIPCLGGTDPNFRRDMTPKDFQALADGTALDPEVGVVLCGLDFHINYLKLSTALHYLRRGAIFLATNTDSTLPMHHSFFMGAGSIMIPLQYASGTKPLELGKPSQAMMDAVEGKFQLDRSKTCMVGDRLNTDIKFGIDGKLGGTLHVLTGVHQKEDWDREDAVAVPAYYADKLSDLAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNK5</accession>
    <name>A0A7D5YNK5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g006530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549854.2">
        <property type="nucleotide sequence ID" value="XM_014694368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNK5"/>
    <dbReference type="GeneID" id="26239298"/>
    <dbReference type="KEGG" id="mbrn:26239298"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="191" mass="21656" checksum="BC815E0851D2D365" modified="2021-02-10" version="1">MSRTVDKLPPPKTRAQVKVIVATASRTGTRSVYEAMTILGYKTFHMKECLYQGGVLHMEILAEAIRAQYSPSSGVKRYSRPDFDKWLAEYDCLVEIPYFLGPGLLKAYADDPNIKFILSDRDPDKWVTSVNKTVGEVITKMNHFPLNVLQYFSRDLHKFLTLNKVIYGAIADGTVPGDRDNKAAMRRNYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNL4</accession>
    <name>A0A7D5YNL4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">P5CR_0</name>
        <name evidence="9" type="ORF">G6M90_00g015070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549018.1">
        <property type="nucleotide sequence ID" value="XM_014693532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNL4"/>
    <dbReference type="GeneID" id="26238462"/>
    <dbReference type="KEGG" id="mbrn:26238462"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="8">
        <location>
            <begin position="194"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="312" mass="32693" checksum="36B3577D23EFE11D" modified="2021-02-10" version="1">MGIAILNGILTSLAEINGPRPLQSPSSNASTPGEERPQSLPSRFIACVRSAESAKRVKAALWEHSSIVKVVQNDNIAAVQQAQVVLLGCKPYMVNNVLGEPGMADALKGKLLISVCAGITADHMEIALHGSVPTTNPEDDGRCRVVRAMCNTAALIRESMTVIGISDPPLPPDMKTLVTWIFKRIGDVVYLPANNMDASTALCGSSPAMFALMLEAAIDGAVAMGLPRAEAQRMATQSMRGTTGLVQSGEHPALLREKVCTPGGCTIGGLLVLEEGRARGTISRAIREATVVASQLGKGVQGVNGTRFNTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNX0</accession>
    <name>A0A7D5YNX0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NUO20</name>
        <name evidence="11" type="ORF">G6M90_00g002750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542808.1">
        <property type="nucleotide sequence ID" value="XM_014687322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNX0"/>
    <dbReference type="GeneID" id="26244181"/>
    <dbReference type="KEGG" id="mbrn:26244181"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="172" mass="19666" checksum="7C6463372CE576FD" modified="2021-02-10" version="1">MATRRSQFHQEVLIDTTPLPDNVPAVKEIGASSAPLLSASFFIGARCRDYNDDYMQCKTENPGRGEFDCMKEGRRVTRCAQSVLTDINTHCLAEFRKHWECLDDRNQQLWQCRPAEWKLNKCVFDNLKLEKKIPDQPKNVTPVELRPKQIFSDVRIGPGDGKPFIAGQDAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPQ2</accession>
    <name>A0A7D5YPQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Polysaccharide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g009880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549528.2">
        <property type="nucleotide sequence ID" value="XM_014694042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPQ2"/>
    <dbReference type="GeneID" id="26238972"/>
    <dbReference type="KEGG" id="mbrn:26238972"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028951702" description="Polysaccharide synthase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45947" checksum="D675339F499322E5" modified="2021-02-10" version="1">MAAVTTLVAFWLWGYIDNRILSGASKRYRPVQRQVGSPGFELAASDVSVIVPTVSTKASFPGCLRTWAANKPREIVIIGVEEEREQVAGLVREAALPPDAATQVRLLFAPAASKREQFRLGVEAATGSIIVNVDDHILWPEAFLDSALPCFHDKSVGAVGPALGVHIPPQRRNSRDVTPWEAAMTRALWRRNSGLAAVYAAAGWCWVLAGSTVLFRGEILRDARFLHGLTNDYWLGRFKLDTGDDTFSSRWLQQHDWNIAIQAMPETRVSRTTVKSGRAFFDQAFRWERSTIQSFLRTLRDVPQIWKSPYVARKTIERVLRPVLTAVHILAWIVSFSTYPRLAEPRRSLLLVYYLWDAVLSYAAFLKEYPYMWRQLGAVVLMDHFYIVQDVWSWLTLDNTSWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR63</accession>
    <name>A0A7D5YR63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g059390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544510.1">
        <property type="nucleotide sequence ID" value="XM_014689024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR63"/>
    <dbReference type="GeneID" id="26242922"/>
    <dbReference type="KEGG" id="mbrn:26242922"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="202" mass="21382" checksum="ED823C4D2C23D070" modified="2021-02-10" version="1">MLDAAGGEDGDADADAGAGADAGANADADADADADAELEPQPAAPLPSPSRRCRRYGLKIALKSNQTRQATQSRELQSQHSTARAEAADTRISHAEWSLPTAPVPVLCMNWQSDDDGKERQGESRCRTYVYGGALGETRPRATGTAGACQSQGSKLWRLQAQMQGTDDIGLIQSSMLPARASKASESKSRQSRPRRRAAETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRM6</accession>
    <name>A0A7D5YRM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anucleate primary sterigmata protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">apsB</name>
        <name evidence="7" type="ORF">G6M90_00g044730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547805.1">
        <property type="nucleotide sequence ID" value="XM_014692319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240368"/>
    <dbReference type="KEGG" id="mbrn:26240368"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="392"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1291"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1408"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1437" mass="162023" checksum="D209F75B059D49EB" modified="2021-02-10" version="1">MRDSKESDSAPEDTGHDANAQPDDSILKLLPPPGGASASGSTTGPSAMESSYVDAVTIDHSRAPDVTITEEAVREHFKDQESSFLPTLSPIATRTTAEDATGADDTIDTSGRKKDQNAEKRDDDHTSDVDVGNTTSSLENLDSSPTTAAAARTISRAVSMASSATRDGRTAPAAADEDDYRDETEHSFLSGADDPFLQSQISDKLDTGSTPSNSLRIGKRSKYLRSRYGSHRSSTSSLITNPESQDGSEATIGHGVDYALQSGGAVPALGMLRSTSNPFQRSISVGSMVSGFGGDDLNDLPNHHLDTLPEVSSPDRPNHNDPLRTPKASRENLKATAPTDTVIAQHVKNVQVPESLVKEYRFKNSLQTPRRPSNLTTSISTDTITKTGRNLTLKEQSSTIERLSKENFDLKLKVMFLSDRLDRLSEEGIKEMISENVELKTSLAVLQRDNKILRKRIKELERQARDEDNRPSTASSTDQTSKTNDEDAYEREQELIYLRERVEEYAIEIERLRNESLSRESEKLQLVQMVKTLGERSGSNAGVPDESAVWSDLLEQETVRREQADEDNRKLRDEIFRLKKELSAQGNMQHTTNIYNISKKPRDGAFSPTRATSGLSGETNVPDTNLGGVNVLVDELRRESEQLRHENAELRREVGAQTSMLTSRNREKERLYQEIEDLKMAQRRGGPAPSTIDSILDRSASRAGGHERSQSRGSGRTRQTLAEEESEREGLENKLAEVRDKLSEVRLQNQELQRELESCMVDFEAAVEGKRQAEDNAMSLQEDLDTAMNDLVALQAERDEAVREQGEMENEFEALRHEAQEEIDAMEAEADQRNEEIQRAYTDLKDRSENFDALQEEMRKMSEALVRLEDEQTGKLRRIQQLEEELDSSNKELEDLEQKLMEANEKNQRFSIQQESSQGEIAFLREEQEVDKIRIGDLEAAIANAEQNLRDEKDRARELDNRLQQERMHREIVADKEKEEVQQVVNELNREASNAKDEVRRLRKSLSSREVEATEWKERLIELENNLREALGDLNGTRSSLLKSIAKMQRELENTIRELDTTKASLVEKDRIIKQRDALLESHALESRKVTELLERERVAHRNTKAQYDTFQRTHQHLTQTASTQDVRIAELESTRGQDRRRLAQLEQTARDQLTERNELLLMLWHKLSALCGREWLNNNTLVDRQVVPSVEVIATRLPGFSKNLVGAIKAIEAMFGGLHSKIKSVERDLHREYQTLENNLEVRTKKLDRLETMLRNSVASGSLAPQDMHSRMARLEDAYRQLKVENATLRTANDVRSRAAHDGTTTPLGRGTTVKGSPSPGIPRGPGDRDRSRTSQLSQDRNSRSGGSSRSNTASGIPRPSSGNFTSMEVALPSEGEPTNNDNRWLLRLRDMEYKLKMEREGRNQDRAAARQRLGGLELENRDLRERVRRTNTDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSA1</accession>
    <name>A0A7D5YSA1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Psi-producing oxygenase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppoA_0</name>
        <name evidence="7" type="ORF">G6M90_00g000410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543025.1">
        <property type="nucleotide sequence ID" value="XM_014687539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244398"/>
    <dbReference type="KEGG" id="mbrn:26244398"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1445" mass="163202" checksum="E703B34F328895DA" modified="2021-02-10" version="1">MNGRAAEAPMSKQDEDLMQLTLQLRNKKEEEKYATFHGDNLLGNPIVPKVGLWQDLKTVFQPSNWPALKRTADGLIKGTGLDGQSAATIAGSLSDYSVQRQKFIDDQVRDKYDKMLHPPLTYLGDAFQYRTADGKFNSALNPHLGQAGAPYAKTVPSRTAPLGALPDPSDLFDKLMAREEGGRQSQSGLSAMLIYHATIIIHDIFRTNDNDKNISDSSSYLDLSPLYGYTTEMQRKIRDDKYKLGLLKPDTFAEDRLLRQPPGVCILLVMYNRYHNYAARQLLRINENGRFRVPVMYEKTKLVSLIKEHLPDRNIYGQKEDLGANVVKMCAEYEKVWREAQAARPRDAPDVPPEQPQETPEEKAEREAEEKQRQKALDAIAEFEASALNQKLIELTEALELLLEEKKSKLKDESPQKLEDFETKCQDFEAAWEAAWNKQDDDLFNTARLITCGMYIQISVHDYLRALMGFHQFNTNFTLDPRADFDQKKTSRGIGNQVTVEFNLLYRFHCAISLKDEAYTEEFMQKVLGFKDPKNTPLPVFLQTMAAIKQKSAEDKKNGKKDPEPWEITFGIPDASTPAPASGEDSSAASENGSDSGISMYGVAGTEAPDEPGAAREKPKRSKYFTRNSITNLFDDGQMLDELTSAMDDPISNFGPRNVPQCLKAVEIMGILQARKWEIGTLNDFRDFFGLPRHATFESVTKNVEIQNALRDLYEHPDKIELYPGIFCESDEHMGLDPGPSEASSALWSAIFSDAITLVRSDRFYTVDWNTNSLTSWGMKEVTPNNEVCKSSVFHRLIQRAFPGWFPSDTIRFFHPFYTAKQNAMYAEAQGYGDQFRETAAEQAGKPKKPKADIVVAPVQKPRKPWYLDKFNDISIVLQGEQSKNFTNPAYYYEANLPQIVRGVLGPDQKPPTISPKILEDYVKGAEEGLKKYLDELMRYIVKRESISMTNSTFQIDATRDFAIPIVTRYVADFLGFGDKLRKVATDAKDKYSENEIYQHITNCQVFLTYNVDETKWMPRREAFKTSMKKLIDLTQKATIWEANQWDITRALFGKKQTNPMHELGVFVAKQVLDYERDQGKAAAILLLICLDFAYNAVVSFTATLDGYMKDLYRAADSTPLTIKSEPKWIEVQRCVFSTSSNADSDLEQMVQLMAQATVRLPIVRKATKTDKYEFGWTTKGRKVQVKKGETVILDLSKAIDEAEVKSDQAKVEFLTSQLNIADKYGVFSPRRFTTLSLVSMIKFVAQMKNPRRGHDAQGKLKKIRLDSTPEGYANYMAPMRVSWIKEQTKRLKDKDADKIFTDDILRPEADTYLTPTWDEFVPFPMTWKIRFDGFGESNYMVDNHPYARVKTTPTLPDFCPPWYQPQGPSAVGGAFASDCVCAAAGAEAEAGGKAAQLANGEAGKGKETEHSHECPCLGRSKGKLEPKTAQLSTGCGLSDNYVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSP8</accession>
    <name>A0A7D5YSP8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547139.1">
        <property type="nucleotide sequence ID" value="XM_014691653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSP8"/>
    <dbReference type="GeneID" id="26239702"/>
    <dbReference type="KEGG" id="mbrn:26239702"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="238" mass="24957" checksum="C57A6D8B8EF16EC4" modified="2021-02-10" version="1">MALPNSTPPLLLTKRLNAFLHANQTPQLPTLLLTTCHGKLLAHASPHPVSVLRTHATVAASLLAIHTSSSVDVPSALPGSRTPDPITSSPILRPDTSDKEDEDDDDDVAPHDVAASKRAAARRRAARSVKPVTITVQLSGGTVIIRRLKCGLLFVCVGPSAHDLQSDVHLQHENGDVTGSPSEVESLVSAGAQTTSSLDSVGAASVVAMRRHAADLARWLDDKLGTLRVPEEGVGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT34</accession>
    <name>A0A7D5YT34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mitochondrial escape protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">YME2</name>
        <name evidence="14" type="ORF">G6M90_00g050540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the YME2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545159.1">
        <property type="nucleotide sequence ID" value="XM_014689673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT34"/>
    <dbReference type="GeneID" id="26242500"/>
    <dbReference type="KEGG" id="mbrn:26242500"/>
    <dbReference type="OrthoDB" id="10267654at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12433">
        <property type="entry name" value="RRM_Yme2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018850">
        <property type="entry name" value="Mt_escape_2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039627">
        <property type="entry name" value="Yme2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034260">
        <property type="entry name" value="Yme2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32198:SF2">
        <property type="entry name" value="MITOCHONDRIAL ESCAPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10443">
        <property type="entry name" value="RNA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mitochondrial escape protein 2 C-terminal" evidence="13">
        <location>
            <begin position="404"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="876" mass="96709" checksum="4285D7117C0FC622" modified="2021-02-10" version="1">MIPRRSLATVTRYPGIVRSTVSLRQPLLGAVAWRKSGHVFPRRLADRAWESTAAPPTPPATPFPSSPASEPASSSSSSSANKEQETGHFDVKPNESLFFFENIFPRKLSSLLRYPTETDGDMTALLRRFYSASGSGGSLDPIAFVKRAIPEDMPVKVTEILPRLKDGGAFVKVQYDASISPSEIESTLLEKLEQHPLKPWFSPFRGIKARLVKGTPWLEDLYRFPSSLVKVEFVPPEPGAAAEELSEENLYSMFRRYGKIADILPQPFDSKVVPKYAQIGFPRLSDAIMARNCMHGFVVTESMGGGKTGTLLRLSYVKKVKAHSIWNWLTSHPRIVIPILAAILAGASVMIFDPIRTFFIKLHVSHSLRFTESRLYKWFKSQTDSLSFKSSRHMDGLNTVWNHRRDVIDQLQNWLDGSTFIVITGPRGSGKSEMVMDQALAGRKNVLLVDCKPIVDASGEAGTIKRLAGAVGFRPVFSWANSISSLIDLAVQSTTGVKAGFSETLDTQVSKILHTTTGALKQIGLSSRSKHDKDAQLSEDAYLEAHPENRPVIVIDNYLHKNEEITIVYDKIADWAASLVQNNIAHVIFLTSDSSYSKPLSRAMPDRVFRTLSLGDLEHKVAKNFVTSRLAEDNPESAKASVEDGKKTAKHMDLTGLDECIETLGGRLTDLEFLSRRIKAGQTPRQAVDEIVGETATDIVKIFLMGKTTESDKKWSAEQAWHLIKSLADAPSLRYHQVLLSPAFASSTSSNAADGEAALEALASAELIALKSHQGRPKLISAGKPLHQAAFSVLVGDRVLKAKMDMAIMKEMAKTEAKTIDAVETELSLLGQLPRQTLETAGRVTYLLEKLDASQRKIDDLEKQMVGLKKVLVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV78</accession>
    <name>A0A7D5YV78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g053820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541020.1">
        <property type="nucleotide sequence ID" value="XM_014685534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV78"/>
    <dbReference type="GeneID" id="26246326"/>
    <dbReference type="KEGG" id="mbrn:26246326"/>
    <dbReference type="OrthoDB" id="5390143at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028972362" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="25394" checksum="681DF7C4125A31AA" modified="2021-02-10" version="1">MLGFILGLVLAAVPSVLSQFFNPKSGAIFTIGGQISVSYKTSLEAYNIALWQQVPDGGAAILGPVILNVTNGPASSFDWTIAVDNLDLTYSKRFFLWLFPNAYAQGNQSAPGSMSSGYFTIVDKTPGPASTSSSLTTLSTTTTASSSSTAATMGTPTSGPDSQQPKTSDGGLTTGAKAGIGVGIGVGALAIIASGALFLRYRSKKDAEIRELRHEMQNKSFAMQSSAYRPAELMHQPRPVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW58</accession>
    <name>A0A7D5YW58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g013680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549154.1">
        <property type="nucleotide sequence ID" value="XM_014693668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW58"/>
    <dbReference type="GeneID" id="26238598"/>
    <dbReference type="KEGG" id="mbrn:26238598"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="281"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="415" mass="47232" checksum="880FD726B09FAF01" modified="2021-02-10" version="1">MSIPPQLIRVKRKRVAESPVTFLQFDQDSKRHRSGSNWAYQRREVAGQQPPREGKSTQPIIHVSAPDKVASHDKRKDEAHIPAKPAQPSETTPRPLEPRRFHMSKSMLAKRAAQGPDSGVSKKTRYGPAVFVESTRKRRVPRRSLAASQLPMQLENELHRAEQNSGSDIERRQLKRPGVTNKSRDTASQNVIPTRDPLPDSLMNRHNEDMDKIANDMNAWVLNELGANLHSMEQDNRPLRFKPKSPAKRFHERHPELAPPQSSGTSTDTTVSDLSDEGDDDDWVIEEYVRIPANSVALDAGPADVGILVLEDEEESLLFFGSSLDEDDELGEDDEDENAENYYTADYPEDEVDSDDEYGRDAYVYRHGNNSDEEEYDNEYYEEQDEMILEGGIDDNDDARMARIKEFMKRNSAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWP5</accession>
    <name>A0A7D5YWP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan endo-1,3-beta-glucosidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glcA_1</name>
        <name evidence="3" type="ORF">G6M90_00g022820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548273.1">
        <property type="nucleotide sequence ID" value="XM_014692787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWP5"/>
    <dbReference type="GeneID" id="26237717"/>
    <dbReference type="KEGG" id="mbrn:26237717"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02182">
        <property type="entry name" value="GH16_Strep_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF60">
        <property type="entry name" value="GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028974253" evidence="1">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="313" mass="34301" checksum="841C24488E15E106" modified="2021-02-10" version="1">MLGHAASVMAIFAQLVLSAGQAPHGRVAKAAPNTPAGFSNCIFYDDFDGDEDSLPDASRWTIDLGTRYDGGPAQWGTGEIETYTDDWQNIRITADGTLKITPVRGHGNSWTSSRIETTADWDFACARGERLRVEARIKLGDNPEGRSLGIWPAFWTLGSEYRGNYQNWPAVGEIDILESVNGLRKIWHVAHCGTNPGGVCNEPNGLGHITEPFERGVWHTIAWEVDRSGDDEESMRWYVDEHLQWTLWEDDVRDAGAWHAMAANSKMILLNVAVGGGFPNGVSGITTPTSDTLDGDGASMEVDYVAVYLEGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWT7</accession>
    <name>A0A7D5YWT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unsaturated rhamnogalacturonyl hydrolase YteR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yteR_1</name>
        <name evidence="3" type="ORF">G6M90_00g110830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543777.2">
        <property type="nucleotide sequence ID" value="XM_014688291.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWT7"/>
    <dbReference type="GeneID" id="26243164"/>
    <dbReference type="KEGG" id="mbrn:26243164"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028801111" evidence="2">
        <location>
            <begin position="22"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="391" mass="41839" checksum="C112415EFD99726F" modified="2021-02-10" version="1">MRLLPAWLLAATACASQHALSTRMLDSIMARQQGIVDSGAASSTLESGILAQAFEYAIAQYPAAKARYGGYLSSVLDKASASFANASYAATRPLDRFSLATAIDAALASHAGPVTARSRAAYAAINASLALQPRNPAGGLWYYVYPEWSYLDGMFSLLPFMAALPRANLSDARHQVELLRDRCTQQNTSLLVHGYDWSRTAVWADPATGASPYVWGRSLGWFLAGLVQAWDQLACAAADDDAAQQPADRVALCSLVRNITVQVSGALVRHADPATGAWWQIVTLPGVGANYLESSSTALFTFAILKALRTGLLCGRTPDYRGTALRAYNYTVGRFVTDTGNGTIGFDKTVSVCSLNSSASFEYYTTRSLVPNSLLGESAFVLAALEVERMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWX7</accession>
    <name>A0A7D5YWX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">H(+)/Cl(-) exchange transporter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CLCN3_0</name>
        <name evidence="10" type="ORF">G6M90_00g047960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544912.1">
        <property type="nucleotide sequence ID" value="XM_014689426.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26242253"/>
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    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0868">Chloride</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="765" mass="83834" checksum="4A4843B376814292" modified="2021-02-10" version="1">MANASNEQHNNTEPHLSETTPLLHASRGRDVESLRSSRNLNHHLALHSTYDGDDTPYRDYATIDWLHDLVKDNTRHGIRDAKVRRVNTTWVRIAKAWDSASGWVAAFLVGLITACVAFVVDVSVETVADWKDGYCTSNIWQNRRACCAAHGDCTAWKPWSQSFPSAYLIYVAFALLFGVIAAGVTTTTKMRLPPVVDLNVADANDKNGSQDTSPIDRPQGKMMYMAAGSGIPEIKTILCGFVIPHYLTFKVLAVKAIGATFAVATGMCLGKEGPFVHISTCVGYLVAKHIPKYAQNQRKMREMLSVACSAGLSVAFGAPIGGVLFSYEEISTYFPRRVLWRSFLCSLVAAATLKALDPTGTGKLVLFETKYGVDYDVVHYFVFIFLGICGGVFGGVFCSTNFLWSKTFRKQPWIKNSPVIEVCIVVFITAILQYPNPLIRETGDIIMERLLVDCNDIKEDWICEQEAKMHGKGLYYAWLISGTFIKLTLTIITFGCKVPSGIIIPALDAGALFGRMVGQLVPDISPGIFAMVGSAAFLAGVSRMTVSLAVIMFELTGEVNFIPPFMVAILTAKWVADSISADGVYDLSQHVMGHPFLDSEQAVVKLRALKDGEESPDLDVLIPPKRVMEQIILPTEPNNQIMISDLRAKLNGLLSGGMFDIGLIIVNEQGICIGYIPESSIAPVLHLIGQQELEGNDLISFADDNFERLVDRSSLNISTRAPLEYAVEMFGNLGLSHLVVVDEDTAKAVGVIGKKRLLSFLGHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX14</accession>
    <name>A0A7D5YX14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tim23</name>
        <name evidence="6" type="ORF">G6M90_00g086320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542482.1">
        <property type="nucleotide sequence ID" value="XM_014686996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX14"/>
    <dbReference type="GeneID" id="26244996"/>
    <dbReference type="KEGG" id="mbrn:26244996"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="233" mass="24595" checksum="5A5F32898F966291" modified="2021-02-10" version="1">MSSLWNAFTGGNKPRQQQHEQTHAFDAPAPSSQTSFDPSQGQGVEAFLQSSTFADPSQLHPLAGLNKDTLEYLTLEDSALSELPGGQSVLPSRGFTDDLCYGTGITYLAALSIGGVWGLQDGLKKSVGQPPKLRMNAILNGMTRRGPFLGNSAGVVAIVYNCINSLIGSLRGKHDSANTVISGFLSGVVFKSTRGVRSMMISGGVVGSVAGVWAIVRRSFFPIPEPAAPIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX94</accession>
    <name>A0A7D5YX94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541078.1">
        <property type="nucleotide sequence ID" value="XM_014685592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX94"/>
    <dbReference type="GeneID" id="26246067"/>
    <dbReference type="KEGG" id="mbrn:26246067"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="301" mass="32910" checksum="496EE8ED20D93D35" modified="2021-02-10" version="1">MAEPKVRRTRIVCVSDTHNCTVKLPKGDVLIHAGDMTNQGSYSELSKTVKWLEEADFEAKIVVAGNHDITLDKDFYAQHASAFHNQSPQSHSQCLQLLTSSPSITYLRHESTTIRLRSPEGPGTRFTVFGSPYSPRYGLWAFSYDVPASPGEDLAPASLWDDIPPSTDIVVTHTPPRGCRDETNSMQTTGCEALRRALWRVRPRLAVCGHIHSGRGAARVLWDEEDGFSATSVRAWEDPGAGNKKVSLVDLTGRKASSLGEGETCVVNAAVMKSSYPHVGGKQFHKPIVVDVNLPLCAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXH0</accession>
    <name>A0A7D5YXH0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain transcription factor CON7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CON7</name>
        <name evidence="4" type="ORF">G6M90_00g041840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547526.1">
        <property type="nucleotide sequence ID" value="XM_014692040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXH0"/>
    <dbReference type="GeneID" id="26240089"/>
    <dbReference type="KEGG" id="mbrn:26240089"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="41162" checksum="42B0F564955ACF5F" modified="2021-02-10" version="1">MDRPVHDYSQTGLPSPYPSSFGDNHSEGSAADHASGAQYPVKQEVSYPTSATPTSEYGVYPQSSRSGTFQEHIQRSYHPATGTGSGGMAQQQNSPSFTQQDGRNHQAHTVHSDTGVPIDPSIAAPSPTYPYGQHSPYAANPDMTHNYSHANSGIYAQPRPDWTGYSQHSQIASGHPVYSPSQASQQAQQRPNQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGQKRTPEEFKEIRKEWKQRKKEEEAQRKAEEERHRAAAAAAQAHNGGPDQGPDVPPTSTYPGSRPVQLPPIGYQPNQYPAPPSGAVPQQQLADYGAGHMYPNYQPHSPYGQPTQSMYNQSNGGPPGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXL1</accession>
    <name>A0A7D5YXL1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secretory phospholipase A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g043180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547652.1">
        <property type="nucleotide sequence ID" value="XM_014692166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXL1"/>
    <dbReference type="GeneID" id="26240215"/>
    <dbReference type="KEGG" id="mbrn:26240215"/>
    <dbReference type="OrthoDB" id="5120271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028999651" description="Secretory phospholipase A2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19798" checksum="066EB126EE95B9C7" modified="2021-02-10" version="1">MKFNNAILLALATTALAAPASDVTTPKRQDINTVTDQLLFSSTLPQFEARRNAKNPPSLDWSSDGCTSSPDNPFGFPFLPACHRHDFGYQNYRIQKRFTKAAKAKIDSNFKSDLYYQCQRELAKGACDRLADVYYEAVKEFGGGDATKRDRSDYDRAVAAYNAAVKEAQEQGLLPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXS7</accession>
    <name>A0A7D5YXS7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hal4</name>
        <name evidence="14" type="ORF">G6M90_00g013370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549184.1">
        <property type="nucleotide sequence ID" value="XM_014693698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXS7"/>
    <dbReference type="GeneID" id="26238628"/>
    <dbReference type="KEGG" id="mbrn:26238628"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="205"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="487" mass="54269" checksum="882D94647B2515C1" modified="2021-02-10" version="1">MPAASGDSSKPSSAQSSKPSSIKSHDGSRHSPGLIAQDFDSASESSHLRPHSERSSVKERFTRMFASKDLPKLNNGNGEHAGRPRGPSLNGASSPASSRKDSSERLSEKPPSNASKVIPGKDLGSRFACNSEVQGGHEHHLKSSRRQEKLSDMWRSLLGKKPEATPDSDLSLVSNWVDSLRQEKEEAGDRKGGPNVSSTLVEKYGKCQEVVGRGAFGIVRISHKKLGGSEKLFAVKEFRRRPEETEKKYSKRLTAEFCISSSLRHPNVIHTLDLLKDAKGDYCEVMEFCSGGDLYTLILSSGKLEVQEADCFFKQMMRGVEYLHEMGVAHRDLKPENLLLTTRGALKITDFGNGECFRMAWETDAHMVSGLCGSAPYISPEEYTDKEFDARAVDVWACGVIYMAMRTGRHLWRVAKKDEDEFYARYLEGRRDEEGYGPIESLHRARCRNVIYSVLDPHPTRRLTAAQVLKSEWVREIKLCKAGEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXS8</accession>
    <name>A0A7D5YXS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g029640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QLI63526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26245842"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="559"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI63526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="559" mass="58369" checksum="66D493B665D4AF16" modified="2021-02-10" version="1">MKVIYLTCWLSSPLLLVSSQATAQPGGNLEVSEIQKITDASQGGFRPFIEFSVAGQVMRGLLDTGSSDLNIPKTGSEFCRGEGEQCDGRTTGFKAGSLDVNKNKTDIRDLNIPLNATFTGGAAFVGTFIESSLQVTPGGKEVPVRMGLVESGGVPPGQVSFPVMGIGPIQGESAKDPYPNVPARFKQDDLSKSNAYGLYLGDFRSPNNGSLVWGGFDAAKFEGELKAAPLLKPDGDSLPAFVVDFSSVGLAPSRDTDQGNNSQGRPNRQKSAVSESDDSIPWSGEFKTSAFTSRRLDNARVPSYAHTSQSLSTRDLLQRQQRGNLLSNDAPPVAWLDTGVPEIILSGGTLDALGRRLGARPGPQGEFLADCNRIRGMDLTLGMNQDNVQVRVPLDSIIVAPDPGSGAGEPGNAGRGNSRQPQRGRNQRGPNKGQNNGKGRGGNRQGGNQQGGNQQGGNQQGGNQQGGNQQGGNTPNGNGQGGNDNIGSGTSPGAGAGTCQLAIAPVQGNGPTDIPVLGAPALQSMYVVFDMDSKALMIAQAKMNETRTDIREYIPGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYH4</accession>
    <name>A0A7D5YYH4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g097170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYH4"/>
    <dbReference type="GeneID" id="90968164"/>
    <dbReference type="KEGG" id="mbrn:90968164"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="27244" checksum="9935E1DD9BB60A9B" modified="2021-02-10" version="1">MTACAPKEEVEWRARLSSPLAQCKIGVATTLTFLDLNIKSLGAVTSKSDPGARRLSIRRATTICPKPALYQVIIKNTSGVRQTSGHGSTSLNMHRSHSLLAAKTRVSFLAPPRSERARLEIILADVWSQEILPFSGMSGRSRSERLVRTSASTVIRKLSVASIASSFAKRASGLRQRMSLEDTFRPVGLQTTPSEVADPGSTSNSENRMSDLERHKASTAAAKRSLSQEEIQGTTKKRSGMSGHGFRGMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYV6</accession>
    <name>A0A7D5YYV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g009350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014694092.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26239022"/>
    <dbReference type="KEGG" id="mbrn:26239022"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="368"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
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        <location>
            <begin position="510"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="726"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
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        <location>
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            <end position="654"/>
        </location>
    </feature>
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        <location>
            <begin position="726"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="864" mass="94749" checksum="3AFD432C92B9FE83" modified="2021-02-10" version="1">MSRPTPPLSRQESVESTRQIALSSFLQEKLQKERRAESEKLNQSQSSLPRSNPDMSVSADLRRTPSSPFKTSMEGNRPQSSAGTDQGKKKGLGVKEMEKVISNLHKQNFDLKLELYHRRERQTTLEERVDAMESDRQRMEEVNDKLLIELEKRDKAVEEAVAMIVTLEAKVDQLFRERAMVHRIENEGFFCPRDYDNMGYKTPVPHSTGPDTMRMEEDAKVVNRMPSFLSDHSETTQNLRNVYLGTQASMLSLTRVTEGSPETDNVQALGSPTLSVLSESSFVSVYGRKDKVMDASQIAADVDETLVLDGADSSYTKERNGKQPSRNHCRSVSSSKTADSRASSTGHFQSITDVIAGSPLQRLEQLDTSYGPNRESGHHPRSQIKDYSKGQLLPDKKPFGLGSIKQDKHDALRRVTTDGQGGVRLHDQALPPTPDTTSSSMLRRFKDSNDTLSQQDLNEENSNGVVLNHLGSQGGSQHNHQLAAVPNELPEEADSWASPSKRAIDLLFEHRGPPIPRPRSADESTASHRRGKGWDSDDDDSDAHSLQSSLDIWMRESAQPSRNRSRASPDLFSFPTGSSKGGWAMSSTFKQNSELAENAPLPPGFDYMRDLFSVRQGLFAGTAPPPPNRRSSLHAQTGSTPEPATSQGANNQGVDQGPPSTARRRSCHSRQNSVDLGKRDDMRTPVQRDQFASPPQPNSDQKPKHYPPIAGQQHGARTGLNRLFRRSTSAAPPGPSSEQSNPVETAVSEQSKSFPTIGIPSWASRHSAVDDDRSGATPPPIMLNPRQGRRHTLGAEGETEKSPAQDLSRSMTPGPTLAAAATASAPSTDIENSPAAAAAASSSSGRRRWLPGFARTNNLKNKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZK1</accession>
    <name>A0A7D5YZK1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g064650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540079.1">
        <property type="nucleotide sequence ID" value="XM_014684593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZK1"/>
    <dbReference type="GeneID" id="26247115"/>
    <dbReference type="KEGG" id="mbrn:26247115"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028976899" description="Peptidase M43 pregnancy-associated plasma-A domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="192"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="368" mass="40037" checksum="70DEDE4D05599121" modified="2021-02-10" version="1">MFLLPSTVAILTASVCKAALINARQSLAGGCGSERPSAHFLQISHHLATNSSLHSSRKRADIEVATFAHVVYANKSVEGGYLSEEIIHRNIDIINHQYAPAGISFSLKNLSYTENADWALGKDEFAMRLKLRGGGYNDLNLYFVADIPYKSEQDWGVRGICSLPTTRPDSLRWTLDGCSLLSRMLPGSNGTAENISNSTATHEIGHWLGLLHTFEGGCGGEGDEIGDTVAQAGPTKLCPTGDPPHSCNLPDPDMIKNFMDISTCTRSEFTAGQIARMKDWEDIRRDVSTDKPTPWLESDEGLVKEFCDKRALSASNSCLAARKYCFAKGKADGYDTLESCVDAYKAGKITSFAWILPTPAYLQGDIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZL9</accession>
    <name>A0A7D5YZL9_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">Highly reducing polyketide synthase cla2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cla2</name>
        <name evidence="3" type="ORF">G6M90_00g111900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="136" mass="14831" checksum="A44C3108421FD691" modified="2021-02-10" version="1">MTAPSTFKTLAKGKVATRIPNDVSFSHAAAIPAQFVAAWQVIHRLARLDEGETILIHTAGNGTVQAAIQLVKSLGAIVYATVGLAEKKQLIIDVSRVPEEHILYSRYASFAKAKPRMDEALMWLSTRWQATSCSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZP0</accession>
    <name>A0A7D5YZP0_9HYPO</name>
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        <recommendedName>
            <fullName evidence="1">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g063190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26244513"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00004">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="240" mass="27011" checksum="B908DF0E75410ACC" modified="2021-02-10" version="1">MAAGPHHDQAIHLVGGPCTGKTRTAEAIAEVCQKQLITINAYDLGINSSIVKRKLRGVFNTACARNTWVLIKRSDEFLAKPTTSDSKTWRELKSTFRQCVRDFEGLVLFSSDRIQDLQPCLQGRISLQIDLSPLGPGQRERIWTSSVKNSASCAGLRRYDLPTDKMEQLIRIDLNRKQIEKAAERWYWSTGDDGLELEDLISIASEMQKVGRRCRPAYAEIDDDGYASGSGENQMDDWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZP5</accession>
    <name>A0A7D5YZP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRYP_18</name>
        <name evidence="4" type="ORF">G6M90_00g108410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544005.1">
        <property type="nucleotide sequence ID" value="XM_014688519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZP5"/>
    <dbReference type="GeneID" id="26243392"/>
    <dbReference type="KEGG" id="mbrn:26243392"/>
    <dbReference type="OrthoDB" id="4915747at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028932772" evidence="2">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="15860" checksum="647CB705970F557A" modified="2021-02-10" version="1">MARKSAIMLAVACSTLLTTAASIDKRLAGGEAAKISEIPSMVSIQNERGHHECGGTLLDSTTVLTAAHCLGSSHAVRAGTLNAHEGGVIANISSRKPHPNYKKRASVYDTPENDIAIVKLLTPIETSAVIEYATLPEDGSNPVADSAAIAAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZU1</accession>
    <name>A0A7D5YZU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NIPA-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g057120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000510686">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mg_trans_NIPA"/>
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    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70044.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="77027" checksum="29CF21D5557D5942" modified="2021-02-10" version="1">MDTVTGAFPWSLTTAATRPAASITTSTAATATATQSPGDPGEVLQQWSSLIGIVTAIVGNVLIALALNVQRYAHTRLHKERVRVRQRARAALKQPQSSSNGASSYGTMPGEPNGHRNGNGRSHDGSVNSASRVHDGPESVETDPLSQSSQSIAPTDVDSADGEHDKTTSTYLKSPYWWLGQILITLGEMGNFLAYGFAPASIVSPLGVVALISNCIIAPAMFHERFRARDFWGVVIAVGGVVTVVFSANQEETKLEPHDVWRAITTMEFEIYLGVTVSLIVLLMWASSKYGRRTSLIDLGLVGLFGGYTALATKGVSSMLSSTLWRAFTTPVTYALLLILLVTAIMQIRYVNKALQRFNSTQVIPIQFVLFTLCVILGSAVLYRDFEKTTEKQAVTFVGGCLLTFFGVFLITSGRQQNEADDEDLLSDIDGIEETIGLTRHGEATAGPPLVQDVESPKPPSQRSSKLSRVSFADTAKPQFPQDKSDKPRIRQGTSDSAPNLIDIEPDPPVLSDNPWRESWSSAASLPRGTRTFSTDSAVAESAVISTPSNSAATTPIRDSAFIHTYPTDRPFTPRQSSGGLSRVPSHHRSKTFISPSPLSSTVTTVVKDAFLRGYDASLANTSSLRRIRSSIRAGLFFNFDEDEQNITTSDLPLPSPLEPSEDEHSETDDPSRRRSRSVSDVIGDFFRPKKKSKNDTPSGDVESGPSHNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z029</accession>
    <name>A0A7D5Z029_9HYPO</name>
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        <submittedName>
            <fullName evidence="12">Streptogrisin-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sprC</name>
        <name evidence="12" type="ORF">G6M90_00g105890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pept_S1_alpha_lytic"/>
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    </dbReference>
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        <location>
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            <end position="19"/>
        </location>
    </feature>
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            <end position="374"/>
        </location>
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            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
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            <begin position="203"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
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            <position position="218"/>
        </location>
    </feature>
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        </location>
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            <end position="219"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="349"/>
        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="38259" checksum="D2822A3CE42C5ABA" modified="2021-02-10" version="1">MELTNFLALLAVILPVAYGAPTQAASLHPQILEAMKRDLGLNAEQATARVAREIHATDVIEQLRSSVAFAGAWINADVLYIGITDQALADEVTAAGATPIVMTNSLSKLEKAKEDLDKIFIGRANALETSSDTSSGIASYFVDVAANKLVIEALADSHGYAEQLASQVGLTTEFQVRTVETMPTTMATVQGGDVYYINRSSRCSVGFAVTTGFVSAGHCGGSGASATTSSGEALGTFSGSVFPGSADMAYVRTVSGTVLRGYINGYGQGSFPVSGSSEAAVGASICRSGSTTQVHCGIIGAKGATVNYPQGAVSGLTRTSVCAEPGDSGGSFYSGSQAQGVTSGGSGDCSRGGTTYFQPVNRILQTYGLTLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z039</accession>
    <name>A0A7D5Z039_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g011160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="CDD" id="cd02341">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041981">
        <property type="entry name" value="ZZZ3_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="480"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="758"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="790"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="860" mass="94212" checksum="A44CC4A383FC164C" modified="2021-02-10" version="1">MSSVSHAGPDAMVTIKVTFEGVTRRAKMPLREMVPRVLEEHIRIFLQIPTDTKIMIERYSDSAAAFVMLDASNMPVYKQLYRAAKAKSKLKLRVSVLPQSDASSPKPVTIEDASESAQTTPIEKPELACANPTPLDAASSARTTLTKQYDSNLLQEAAKIIQDHQAEFHNHIRQVMKSTDELASLTSQMASCQPFTTTSNAPEPSEPLSPVCPATGAMFAVCCNSCEQSIPDAHYHCSTCDDGDFDLCQSCVDQGITCYSDDHWLIKRIMNNGQIVNSTTETIAPKLKLVANAAPKDDAAKVDDSEKEIFLPGLFEKQTLPPAEYFCTRLAKPVTQRAIARFAAVGNMRTCNQCVRELPEREFLHCTDCEDYDLCQPCFAKDAHGHHPKHAFTAAVPGTEMPTHIRVKMNSGRNQVHHAICDGCDAYITGVRHKCLDCPDWDYCAECAENAHFVHPNHRFAAIYEPLADLHTSFLSQPVHMGICCDGPLCSASNAITSYIRGIRYKCAVCHDLDFCANCEASPANDHNKTHPLIKFKTPVRHVSVTTTGEHQDGKRMPAMGDRSSTISKATETVGSSAANAVNAVQTVVDVKPTEADIPPPVPSEKPLAKSELDSVAAPPAPTTEVKDEELRAVFLRDTVADGTIFPPNHVFEQTWILRNEGATSWPAGCCVKYVGGDYMGHVDSSHPAGISELVSASESTICYAPLAPGQEYSFTALLRTPIHSGKMISYWRLTTPDGMRFGHRLWCEVNVRAVAAPEAKPQAQSSPTSVKNEPVGEPSQSSSVMIFPKLEKESPSASVHEDAETESPLASAEDGFGQCDEDDEWDASEDGFLTDEEYDILDASDEEFLEEQEKKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0M0</accession>
    <name>A0A7D5Z0M0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IMP2L</name>
        <name evidence="14" type="ORF">G6M90_00g021600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548388.1">
        <property type="nucleotide sequence ID" value="XM_014692902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0M0"/>
    <dbReference type="GeneID" id="26237832"/>
    <dbReference type="KEGG" id="mbrn:26237832"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="182" mass="20636" checksum="7ACBA71669A33056" modified="2021-02-10" version="1">MAPGSIWSRLRIPPSGLARAVTLNLMGFATWIPVIAWFNMHVAELTFVDGSSMYPFLNEDKDSTLRRDFFLNYKWSPQEGLERGMVVTLRSPYNPEVVAVKRVVALEGDVVRTKKPYPIPTVRIPQGHVWVEGDGPAGSSLDSNTYGPVSKRLLTGRVTHIVYPLRKFGQVRWWEHESKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0T6</accession>
    <name>A0A7D5Z0T6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g002010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542879.2">
        <property type="nucleotide sequence ID" value="XM_014687393.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0T6"/>
    <dbReference type="GeneID" id="26244252"/>
    <dbReference type="KEGG" id="mbrn:26244252"/>
    <dbReference type="OrthoDB" id="4936877at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="40485" checksum="3B46CD8FA26F1F47" modified="2021-02-10" version="1">MPLIMNADVDKLDGLAPRSCKLCHKKEGVARCSACLAVFYCGRECQVKDRDFHKKPCTLIKKNRLRYKSEQKKLREMPSGPFLPDNVFEDHVGRFWGILGTRPYMCARYALVDAMLITYGTAGGPVDVVQMSLDHLLDMMRLCRSDNLCLRKLIPGLYIRLGRDQDAYDFMKWYATTGQKTDYNWGNMEEPFLDTKDADVLEAPVKSWKGRVLDPNHVVAVVLIKVRIMLDLQVIQNARIADRGDNPEETIKIIGGKLVSPIISSRAESLLAEPQETARLAGKIKKQIKQLYDAVGSYNRHFWDLLVEDPDCGVLRRPASNPPQSKNEAIEVVKYSYASWYKTPGAVSVLRNLSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0X2</accession>
    <name>A0A7D5Z0X2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g024600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548122.1">
        <property type="nucleotide sequence ID" value="XM_014692636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0X2"/>
    <dbReference type="GeneID" id="26237566"/>
    <dbReference type="KEGG" id="mbrn:26237566"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028807767" evidence="2">
        <location>
            <begin position="21"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="223" mass="23587" checksum="A73CCDB8D4198973" modified="2021-02-10" version="1">MASSRALALALLALLKACNANDRGSTPTPTVTTAPIFIPYYSEEQWSAVRGSIVSMNQTATQTTYTIFCPTATQVACDLSLEFPFIIVEGPSTLKFHGTLTSTYIADLECNMKGTTAATCSGYSSYCSGYTNGKYTGPTEVSWTSTLTGSNIHWGTLTLADKPSETDDSLEVTATNIAVPTVPSSQTYNSTPTQTGGGDNLHSSRSWAPTTALLSIFASVVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z151</accession>
    <name>A0A7D5Z151_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat domain-containing protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKRD17_0</name>
        <name evidence="4" type="ORF">G6M90_00g048700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544983.1">
        <property type="nucleotide sequence ID" value="XM_014689497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z151"/>
    <dbReference type="GeneID" id="26242324"/>
    <dbReference type="KEGG" id="mbrn:26242324"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="428" mass="46605" checksum="19EFB54C9A6D7625" modified="2021-02-10" version="1">MAHDSSQTEGYAKLLHDAVRQGDVESVGKLVCEYKRPNEPFEGRLPLVTAIRNKSHDVIKVLLEHGADVKLKGTSGRSPLGMAINMKDRILLETLLRYCGSLADHADEHEPEPLLWNALEARDEAMALMLIEHGADIKQRRNACEYSPLMVACHGRLPRAAQKLIEMGADVEDRSWDGMSPLMVASQRSDLATAKKLIDFGADLEAKKPAGGYTALYYAVWYRRPDMTELLVREGAQVNQPLAGGFTALSVAADNNSPEIARFLLANGADVNRATGSVTACIYADGLHVDDLPADALLTPLHLAAENGHADMARLLLDNGAQVNAASTRGYTPLMLAAHNGHADTVSILIRRGADISAHAADGSRALSIAALFYDGLLRREVKLGRPSTARPRASRFGFERDCEQPPRQYERVIALLAKAGYDSHMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z179</accession>
    <name>A0A7D5Z179_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g080120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539513.1">
        <property type="nucleotide sequence ID" value="XM_014684027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z179"/>
    <dbReference type="GeneID" id="26247677"/>
    <dbReference type="KEGG" id="mbrn:26247677"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="67991" checksum="46550386EF9E980F" modified="2021-02-10" version="1">MEASRQPGQDNDSHAATLTPRAVACGILLGIVVCLANIYFGLQAGMVSPMPMQSALLGFAIFQSIRPRLSKALTPMETTLIEVIAGSLGLAPFTLGLTSFIPALEFLTKPEENGPFKFTNGQLLLWAMATCGLGIIAAVPFRRLLILRESLPYPSATATGALIGILFKRPDIIARAKQTQMRPRASRVSDINNVYSERDEADPGGDTERLLDENSRREEEEGLGRDTNRPALRMLLYALAASLSFSFIAYFLPILHRVPIFGLHAASHWMWAFDLSPAYIGYGVIIGPSINAYVLIGAIVGWGILSPVAKHRGWAPGPITDFENGPRGWILCVGLGFILGDTIVAVGWICSKPFICRARRWVSNIVQRKQLSSSHGQRDGTETPLLRESPSSVNTANETAMAQDDGWPKSCLITTRLVGWIGAALLLLYFISIPTAFGHLTSVPATLLAALLIPLAGFISMRSMGETDNGASVAIGRFAQFAIARLFSFSGPKFTSANLLLGGAIESGASQAAQQMGNLKIASITQIAPRAVIFAQMIGSYVGAFIAIFFYKIYSSLDKIPSEEFSIPDAHLYITTSRFIRWQGLPPGLTGFLMGSFALGAVFSVLRILSLKHWWRCLVPSGIAIAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1I9</accession>
    <name>A0A7D5Z1I9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fcp1</name>
        <name evidence="10" type="ORF">G6M90_00g053930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541011.1">
        <property type="nucleotide sequence ID" value="XM_014685525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1I9"/>
    <dbReference type="GeneID" id="26246317"/>
    <dbReference type="KEGG" id="mbrn:26246317"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000142">
        <property type="entry name" value="Similar to FCP1-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="154"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="505"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="807" mass="90224" checksum="E91377D68CFFADE6" modified="2021-02-10" version="1">MYDKLVSLGSRLHYPITITKLLKSPGDSIKKQEIIIEYKFTWRRKVSDDEWADETTYTEYDSPAEGKLKEWRIKEGMVINADTPCMLVEEACGHEVQIQGLCSLCGADMTEFNWATEERDTDRAMINMTHDQTGLMVSESVAMKAEHDTQKRLLRQRKLSLVVDLDQTIIHACIEPTIGEWQKDASNPNHEAVKDVKSFQLNDDGPRGLASGCTYYIKLRPGLQEFLEEIATMYELHVYTMGTRAYALNIARIVDPDRKLFGNRVISRDENGSITSKSLQRLFPVSTNMVVIIDDRADVWPRNRPNLIKVVPYDFFKGIGDINSSFLPKRTDILPAPPQSNGSALAPNNNTNGANGASTDVKTSPLEEIARMGGAVDEVSLKIQAEEQEKSLEKQLTDRPMLHMQEQLDKEDEMSAQDTETGDSSANHPRQHLLNDDDEELIALQDHLTDLHSSFYETYDRRREERRQSEPTHPPGHSKPRRRSSVDDGVDLSMVPDVGDILDELKSNVLSGLVIVLSGLVPLGVNIEDSEIGMQAQSFGAQVLDSVSRRVTHLVVSLARPRTKKVQQAAKIPSIRIVNHNWLVDCLSQWRRLDERPYYLNVAADRERSDDTTEATSEAENVEAEARDLKDFDWATADKDLEEFLGTDNDDEEDEEGEDNDEEEEEGDRDMDMGDIVESGAEADKDGDTDSSRTNSPIKKGKKRKLPIEEDESDGDGRGIVGESLLAKKQRLARNRGASGLRSVRTTNGDDGEDEGSSLPTPGPTNDEATVVSNKAAATEPAHDDEGDVDDDELERELLAELEAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1P7</accession>
    <name>A0A7D5Z1P7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">YME1</name>
        <name evidence="16" type="ORF">G6M90_00g033920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543319.2">
        <property type="nucleotide sequence ID" value="XM_014687833.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1P7"/>
    <dbReference type="GeneID" id="26244120"/>
    <dbReference type="KEGG" id="mbrn:26244120"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="366"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="772"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI66947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="817" mass="88664" checksum="61B1C9C2276FC45F" modified="2021-02-10" version="1">MAFHGVPAMVSAAAEAWPSIANSLMGPWRSATLPTRRLKPTPISDSQAVGPTASKSSLTQLPDFIRAANPSIYTLPPIPKGAVPMKIHNAVSNLSQIGLRAANPVLRQPQFQPKGYVPRAQWRPLVSIDMPRFTFQGVTMQRRGFGTGFGSSNGISRNQLATVEESANRNAGNANMQNAFYQLLLRANMPGILVERYQSGRFATNAATEEAYKKALTALNAGTNTTSGPSAPSGYARGQWATQEQAIANAAVAGSSYGSGAKGGKGEPIHVVVQESTRSLIFRWVKFFATFVVVTYLCFAAVTILIETLSTFRRGPGAKTDSEVKAEKQTTRFSDVHGCDEAKEELQEVVEFLKNPENFSDLGAKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFYMSGSEFDEIFVGVGAKRVRELFAAAKAKSPAIIFIDELDAIGGKRNPRDQAHAKQTLNQLLTELDGFDQDTKIIIMGATNLPNLLDKALTRPGRFDRHINVDLPDVRGRLAILKHHAKKIKAAPDVDLDAIAARSPGRSGAELENMLNLAALRASRARATVVSKEDLDWAFDRVTMGAERKSMVVTEKEKEMTAYHEAGHALVQLFEKDSSSRLYKVTILPKGPSLGHTAHVPQMDKYSYTAAEYMSNIRVLLGGKMAEEMRYGDDKVTSGVSNDLEKATDLSFMMITNFGMSNVLGPVEYGRRYENLSSETRAMIEGEVQKTLKKLYEDVRKLLTEKRKELDLLAQALVQYETLDKKEVELVIRGEKLPGRSIVPRGPLVLPIPSDTPQPPGLGNVPHPQPSGSEAPPPAQADSSGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z282</accession>
    <name>A0A7D5Z282_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ubiquitin conjugation factor E4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ufd2</name>
        <name evidence="14" type="ORF">G6M90_00g033400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986343.1">
        <property type="nucleotide sequence ID" value="XM_066130127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z282"/>
    <dbReference type="GeneID" id="26244071"/>
    <dbReference type="KEGG" id="mbrn:26244071"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="994"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI67307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1085" mass="122981" checksum="02C4DEC1028D0903" modified="2021-02-10" version="1">MDPNDRPPPSGPDDAPDRDHMRARRIAMLGNIARKPSEDKTDSSSNQPASSSTSTPKPQTSEASTPKPKINVTPAATTQSNPNPFARLGVQSSKIAGDESAATGSSRPACKRPAPDVDDTDSAPPAQKPTPQLVQQQQQQKSETDEDYAHRVLSQVFRVSVDPHHMANPQGQRLVFLPNLNQELNDSGDSLKLSIEYLLPCWKRAVRASSTAKNVSAPRQEILDEAKRLCMSNCLFALTMPALYGRDPNPQHDTLVPYLLKGIQDDGGLCFDFIREAIKRFDEDEAFPALFNDAMIKISSQLSTLSLGDEYKPHVQALLTYTRFPVLIANLAQHPSFNMAQSAPGIERHTILGPFFRISPLQPEAIKSYFPGARSLDRVRISNAQESLRIVLRAHQDDLFVIANAFIRAGPDTRSRTLNWFAYIVNMNHKRRAMQVDPKEVASDGFMLNVTTIMDRFCEPFMDNDFSKVDKIDVRYFRRQPRVDIKDETKLNADQATADEYYSKKVEGDSNFISEAFFLTLAAHHYGSEALNSQLKNLDREIKYLDKHIKAMEAERPKLANSPHQLRLFEETLKRHTNVLEKTIALKHAIEGALLDERMQSTSLRFMRYVAVWLLRLVTGSDYKPGQETQMIRLPLSSDNAEAFACLPEYTLQNIVDNFKFIFRFLPKIIPSAVGDEMIALCITFLRSSEFIKNPYLKSSLVSLLYSGTWPFMHLKKGVFGDQLIALPFANEYLLNALMKFYIECESTGANTAFYDKFNIRYEIFQVIKCVWSNDVYKQQLTRESKTNRDFFVQFVNMLLNDATYVLDEAFTKFPKIRSLERELEDTSLSAEDRQKKEEELQTLGSQATSYMQLANETLEMMKLFTKALSESFIMPEIVSRLASMLNYNLETLAGKRAAAELSVSNKDKYHFRPIQLISDFVDIYLHLGYSPVFVDAVAADGRSYKPEVLDRVTRILSSKNAKDPADLAQWEKVKAKFEVAKHELDQAELDLGDIPAEFEDPIMGDLMKDPVLLPSRHIVDRSTIVQHLLSDAKDPFTRQPMTIDDAIPQTELKERIGKWREERVKIAKEQAVGLRGEQMDTTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2M5</accession>
    <name>A0A7D5Z2M5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g047140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544835.1">
        <property type="nucleotide sequence ID" value="XM_014689349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2M5"/>
    <dbReference type="GeneID" id="26242176"/>
    <dbReference type="KEGG" id="mbrn:26242176"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="3">
        <location>
            <begin position="318"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="479" mass="54802" checksum="AD300A41EEB25947" modified="2021-02-10" version="1">MGESAATTFASIFVLGVGFAGAGYLYHKSYKMLVLKKMTRAFEPGDPVLELAAVGKDVPHSHPPGEEHWVRRPEQEHIDRIITGQEVGHYYFILGEKGSGKSSMLIEAMRKIDGDGVAMFEAHADPEIVRIRLGKALDYEFHEDYIGGYFSEKGPRDMGALLDIERAMNKLEKVAMKLFRIRKKPLVVIVNQMHLLRNDDVGRNLIELLQQRAEQWAAAGLVTMVFNSDDYWVYERLKLLSTRMEVLPVTDLPKKQAIQALQRYRIRYFGEKMTQEQLDDVYDRVGGRLSFLNRVAKSHDMLATCEGIKDIEKKWFLNQCWIMGTEMDDDVMDQQKWAAAAMVLAHALVEKEESMTSTYDPVVGHILPTYPFHIAQEIMTRCDFIRDLDSLNLFTITNQADVRASSVPMHRAFREICSQPGFKEHLDNTIERIAAIESLGRTRELVAKDLVLGGQYDIQQERNKVTVRLKMPEEEEKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3M9</accession>
    <name>A0A7D5Z3M9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trafficking protein particle complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g038440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547202.1">
        <property type="nucleotide sequence ID" value="XM_014691716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3M9"/>
    <dbReference type="GeneID" id="26239765"/>
    <dbReference type="KEGG" id="mbrn:26239765"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012880">
        <property type="entry name" value="Gryzun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021773">
        <property type="entry name" value="TPC11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374">
        <property type="entry name" value="FOIE GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14374:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11817">
        <property type="entry name" value="Foie-gras_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07919">
        <property type="entry name" value="Gryzun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 11" evidence="2">
        <location>
            <begin position="330"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Gryzun putative trafficking through Golgi" evidence="1">
        <location>
            <begin position="623"/>
            <end position="1199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135221" checksum="C253F23D6D74C99D" modified="2021-02-10" version="1">MDGYPPGSLDHNVPFLVASGLNSAEPELDLQGELSTQGQLIKSDLPPLEGREAQLLETYFEEIDARGTSWAVVPRDEPYRFRIKTVGRSYLLPPRKTIIPDSVGPPDPSATIHSPFSPLSHVSALYPDGLIDSRWIKKHQHLVPSIYACFYSLANDNRLKLDVNEIKATLARSGFKTRVAIILFGNQDSGTAVLTEEVQDRLEGIRKGTALDPKSIFYIPTQESPAELKRKIDSILAILYSNAVEYYRDLGRHARKKRSRGIAPQPTIPPTSGTSHTLSLPDWNFRYDMKTAILAEFRQELDPAIRSFEQAYEILLGQDVFDIIPSWSSRWNEARQLADIVSIRCLRLHLWMGHTSLAVKRWQTHRDRIGDLVDRRGQGTNTYGWQAWEARWAMVMANLMEKIEVSGLAPASMTIFLPPERAVLGERLQPWELLHHTGYWYRMAARHLTARRTLAHMIPDEDREPPESASAKSAKSTYDTYMCPPPYQENPLSGDGGVSHAQLIIDCLIASRTQFEARGQLRIAAELSLECAKEMATLGSWEEAVAILQPVWDSSSYRAENWLDISEDLCWLLRRAAKEIGRADLLVAADWELMNKKFSKRQHWRYDLSQSLDGVTVEEKPSIQLSDASSSHLISSSFVFRSKENKAGDQCLAQFTLTSNAMADSMPISFSSVKILFGGSLKPILLRHGSSGEESSFITKVALEEQFSTDGPGDLPSSLSGTCDLTLKPGEKRVFEMAVPLRESGEAEASTVVATYEHKSFDIEYTMSFRDTDQVTGWYIKTSDRPRQLRPDARILHIKPRPPKLLVSLLESSGQYYTNETVELGVELRNEEEEPANVKLDVQLYGKSVSSFKLQVGEHERNGETGEDESKALGVPVGVISSGAVAELKLTIDPTTAPTTHDLHIQATYHLESDTATPIIQVLSLSLDLVGPFEANYDLLPRLHPEPWPSLFDYEGLHLVTEGETAASPAKGFAQQWCLVCHYASFAMEDLTVLGMELQVVSCVGGARCTVTRQPEVAGDGITIPPKTIHEAQFDLVAQKLSLDDRHPVTLDLAFVIKWKRKTAPVDGQANVTALPVGQYLVLGTEPRVLASALYSNPTASTNLLHLDITIENPSNHFLTFGLSMEPSDMFGFSGAKQTTINLLPMSRRTARYRLLPFVQGDYIRPGLVVRDKYFQKVLRIIPTEGMKIDKDGLLVWVPGDGSKDSERGAKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3S6</accession>
    <name>A0A7D5Z3S6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g071260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545933.1">
        <property type="nucleotide sequence ID" value="XM_014690447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3S6"/>
    <dbReference type="GeneID" id="26241966"/>
    <dbReference type="KEGG" id="mbrn:26241966"/>
    <dbReference type="OrthoDB" id="10425458at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028854960" evidence="1">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="129" mass="12462" checksum="1668F8ED9E69F9FF" modified="2021-02-10" version="1">MRFSIVSAVIASAGLVAAAPASEPGKREMNLGGIPGSGLIGGSGSGAANGVTDAFQQALALLFGAGDAVLNNPLDAVTKLFTNPTQAPADIAKNLMGSVTGLAKGAGNVVTAIPKGVGQDMAKASGKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3T3</accession>
    <name>A0A7D5Z3T3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g008680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549642.1">
        <property type="nucleotide sequence ID" value="XM_014694156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3T3"/>
    <dbReference type="GeneID" id="26239086"/>
    <dbReference type="KEGG" id="mbrn:26239086"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="245" mass="25897" checksum="60E9E337C9757634" modified="2021-02-10" version="1">MSKFYAIVAGAGSGTGASVALRFAKTYPVVLLARKSANYEPIVQEIRAAGGSAYGYTADASDPASVDGAFAQIEKDLQGHKLAAAVYNANAGFAYKPFLELKVEDLDTSLGTAANGLFYFAQKTLPQLLDAVSSSPHPPSLLVTGATASIRGSAKFTTFAAGKFAQRAITQSLAREFGPQGVHVALAIIDGVIDTPWGKERTANNGVADGKIAAEAIAESYWHLHTQPRSAFTHELDIRPYVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3T5</accession>
    <name>A0A7D5Z3T5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Arl8</name>
        <name evidence="7" type="ORF">G6M90_00g085540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541112.2">
        <property type="nucleotide sequence ID" value="XM_014685626.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3T5"/>
    <dbReference type="GeneID" id="26246101"/>
    <dbReference type="KEGG" id="mbrn:26246101"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20605" checksum="BD7B4E1CCABEBA6A" modified="2021-02-10" version="1">MAGIFKKVYDWLLRTFWAMEMEVTLVGLQNAGKTSLLRVLAGGEFTLDSIPTVGFNMKRVQQGHVTLKCWDIGGQPRFRTMWERYCRGVNAIVFIVDIADVDLIPQAKDELHSLMSYPTLAGIPLLVLGNKSDLPQKLSVDELIDELDLKLIQGREVCCYGISAKEETNLDAVVQFLVKWASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z405</accession>
    <name>A0A7D5Z405_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Toxin cluster protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g094060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540771.1">
        <property type="nucleotide sequence ID" value="XM_014685285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z405"/>
    <dbReference type="GeneID" id="26246384"/>
    <dbReference type="KEGG" id="mbrn:26246384"/>
    <dbReference type="OrthoDB" id="4933605at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25980" checksum="429651FC44285648" modified="2021-02-10" version="1">MTKADLTLSYIDGRPSTVGIKAVNEVLRTVGVHANRAPSPPEARPILEASKTRALSEDEQAQLISMFSLHRSDLLAQIQLAGRTPEVHDGGHLNTSEHGVAPYPKVYDMQAMDQDAKHLVQARFGRLHVNTTDKGVGIDEVMTVVSGGPMTWFYQLPDGAVVKLSVPVVETGGPAWRLSYPGKRPHGAFLDAEHGLIVAYAHGPEKFVMRYEVPSAQGSEALATNPWIDFGGDAPRLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4E8</accession>
    <name>A0A7D5Z4E8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Cytochrome P450</fullName>
                <ecNumber evidence="14">1.14.14.1</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">NADPH--cytochrome P450 reductase</fullName>
                <ecNumber evidence="14">1.6.2.4</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="19" type="primary">CYP505_1</name>
        <name evidence="19" type="ORF">G6M90_00g027270</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <cofactor evidence="14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="14"/>
    <dbReference type="EC" id="1.6.2.4" evidence="14"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986109.1">
        <property type="nucleotide sequence ID" value="XM_066129983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4E8"/>
    <dbReference type="GeneID" id="26237304"/>
    <dbReference type="KEGG" id="mbrn:26237304"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 14" id="KW-0288">FMN</keyword>
    <keyword evidence="4 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="12 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0521">NADP</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="518"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="694"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI66209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1086" mass="120360" checksum="07CFD4720AA829FC" modified="2021-02-10" version="1">MAVDTVPIPGPSGLPILGNVTDVDIDHPLQSFIRLSDRYGQIYKLKFGKHTLVVVSSYELVHEVCDDKRFKKSIEGDLEQLRKVVHDGLFTSRGVEEENWGIAHRVLMSAFGPMSIRGMFDEMHEIATQLALKWARQGPSQPIDVGEDFTRLTLDTVALCSMGFRFNSYYRDGLHPFIAAMYAVLKEAGAKSLRILPPMFYPRKEEKYRENIALLRSTALEVLESRREDGADAASTDRSDLLSKMLNGVDLKTGRKMTDESIIDNLITFLIAGHETTAATLSFAMYQILSRPDVYHKLQQEVDAVVGTGPVLIDHVAKLRYLSAVLRETLRHSSPIPAFAREAIKDEVIGGKYAVKAGEQIICLLSKSHFDRAAYGSDVREFNPERMADDKFDRLMKDYPHAWSPFGTGMRSCIGRPFAWQETTLALAVLIQNFNFVMDDPSYRLQIQETLTIKPKKFMVRAILRDRLTPSRLETRLASAFAGEAPTPSPGVPAGHKSRHSVASTSTGHVDGESAPKLVILYGSNAGTCQFMAQRLASSAAAKGYKSSVDALDTIRGSMPKNTPVIIITSSYEGEPPHNAAHFTHWIQTLEPGAMKHVSYAVYGCGHSDWVHTFQKVPKLIDSTLETLGASRLGPLHSTDAKDRDMFSDFEAWEDDVLWPSILERFARPSDAATSSAPGLALSFSTPRASVLHQSVEEATVVAARRLVDQSGGSQEKRHIELRLPANMPYSAGDYLAVLPHNPKESVSRALRRFHFPRDAYVTISSSSPTTLPTGMSLPVAEILSSYVELGQIATKRDLAHLCEMNKESDEIPQLKRLVGEEFDTVVKAGQLSVLDVLEKFPALCVPFHEFLQMLPPMRLRHSVSSSSLFDPTKVSLTYGVVNESAVSGTGRFIGVASSYLSSLEPGEKIQISVRPAQSGFHLPENQEETPIVCIGAGTGLAPFRAFIQERATLQGSGRNLAPAILFYGCRNPLSDDLYRDEFDAWEKSGVVKIFRAYSGDKEASCGCPYVQDRIWHERGSITNMWEKGARFYVCGSGKMAEGVKGVLVKIVTEEYEKAGEPVTEEEAVGHFERIRKERYCMDVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5B1</accession>
    <name>A0A7D5Z5B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IPP1</name>
        <name evidence="12" type="ORF">G6M90_00g101640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546181.1">
        <property type="nucleotide sequence ID" value="XM_014690695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5B1"/>
    <dbReference type="GeneID" id="26240604"/>
    <dbReference type="KEGG" id="mbrn:26240604"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="309" mass="34811" checksum="A27BFA611CB705C8" modified="2021-02-10" version="1">MASEVSYAVRKNGALNSPEFKLYIEQQVHQKGAKVSSKVISPFHDIPLYADKEKGILNMIVEIPRWTNAKLEISKGQELNPIVQDKDKTGGLRFVRNCFPHRGYLWNYGAFPQTWEDPAHEDQHTAAYGDNDPLDVCEIGEQVGYTGQVKQVKVLGIMALLDEGETDWKVIVIDVNDPLAPELNTAEDIESKLPGLLRATNEWFRIYKIPHGKPENQFAFTGETKNKEFANDIIKECHKAWSRLLDGKTEPRQGQREKAADKIKITNTTLVGKGDYRATPPEVKPHEELPPAAVDPTSEKWYFISGNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5S1</accession>
    <name>A0A7D5Z5S1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g048100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544925.1">
        <property type="nucleotide sequence ID" value="XM_014689439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5S1"/>
    <dbReference type="GeneID" id="26242266"/>
    <dbReference type="KEGG" id="mbrn:26242266"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="489" mass="55140" checksum="B90A93BDF7F04098" modified="2021-02-10" version="1">MSTPLEFPPSFVRPWKELLLSRQREQLGDLPNHHARDPESLITTSSPQTLYVGTGHSIFTRSILPAILGARSSVHFVTCYWAASPSLDAIRDTLLQLAALRRADGGAARSTLQITIGFSSWGLFQKLFHTSSRDGQLYPPSQWGKLGLPDQRTLASGGIQLTVKSLFFTPFSVMHPKYVIIDGERAFVPSCNVSWERWFEGCVELQGDLVQILMAFHGRVWGTGVDQSSSIETADGRESGPYISEGDSRTVDTENSETMFSPEDDISAIKSLRITGNDNVPTILLPSSHHRNPRFSFFPFLSRSNPPMTPLNAALLTLFNNARRQIIILTPNVTSWPVLKALLDALSRGVDVQIRTNKGMMLLEQLVTAGTTTSWCLRKFVRQYQQLRVKSKSSDIEAPPVRLGQLEILYYNAVPRRRGMEDEPVVSHFKMTMVDHEYLVLGSGNMDRASWWTSQELGFLFYVPGVDWHKLWDGVLEKRMEVYYRSRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6G9</accession>
    <name>A0A7D5Z6G9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g034740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546870.1">
        <property type="nucleotide sequence ID" value="XM_014691384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6G9"/>
    <dbReference type="GeneID" id="26239433"/>
    <dbReference type="KEGG" id="mbrn:26239433"/>
    <dbReference type="OrthoDB" id="5415867at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028852578" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19666" checksum="F0E315F40AB3E5C3" modified="2021-02-10" version="1">MSLKAIATLLLAAAVSAAPAPSNTSPSDATKTTTLTGVTHSVVAGLGGLRFDPDNVVAEIGDIVEWHFLPQNHSLVQSSFAEPCKPLADGTGFFPGFEFVTSQGQAPNVFQLQVKHKKPLWYYCPQQKGNHCQQGMAGVINQNFDNPRVSLQRYKEAAALTGTSVIPPVNNVGRVIPNPNPNGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7T4</accession>
    <name>A0A7D5Z7T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta,beta-carotene 15,15'-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Bco1</name>
        <name evidence="6" type="ORF">G6M90_00g112410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540309.1">
        <property type="nucleotide sequence ID" value="XM_014684823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7T4"/>
    <dbReference type="GeneID" id="26246903"/>
    <dbReference type="KEGG" id="mbrn:26246903"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:carotene catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
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        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
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    </dbReference>
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        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
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        <location>
            <position position="357"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI74123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="580" mass="64200" checksum="D8F29ABBF5F6BC19" modified="2021-02-10" version="1">MSAAMNDPSVIRRTAADEEADAKEALQNFENQRWISWPNEGAFDALDEQYDSVHLKVKGSIPSWAAGSLFRTGPGQSMVENTSRGTHHVSHWFDGFAHTHRFDIIPPPAGDSATSVVYSSRGQSEEYIAMVKKHGWQTSVSFGQRSDPCVGIFAKFMSIFLPQKVNNNVAVIANMPGLDSSGGRRVGHRTGLDNVYITTDNSTLEKIDPETLEPLGSAAQQQLHPKLKGPLSCAHAQKDPVTGDLFNFNIDLGRRATYRIFRVNADSGTTDILATIAENELPAAYIHSFFLTENYVVLCVPTSHFGWNGLKILWERNVIDAIQPFDKSVKCKWFAVDRRHGRGVVARFSTPASFFFHSVNAFEQKSKGSNGEEITNIFLDMVEYVNTDVMHMLYYDILMNRNQDAIKDLRKRDKYKTSQPKLVRYKFALPALSQTHMGDYSLAAEQVFAILSPHAGELPIINPSRSGKAHRYVYGTCNRGVGFWMDGIVKTDVETRDALIWSGPVGHTPGEPIFVPRPGGTDEDDGVILTVVLDGSAQTSYLLCLDAKTLQELGRAETDFPIPIGLHGIHTPLGEPSVPS</sequence>
</entry>
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    <accession>A0A7D5Z7V8</accession>
    <name>A0A7D5Z7V8_9HYPO</name>
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        <submittedName>
            <fullName evidence="5">Sad1-interacting factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sif3</name>
        <name evidence="5" type="ORF">G6M90_00g057630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
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    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
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    </dbReference>
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        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="318"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
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        <location>
            <begin position="54"/>
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        </location>
    </feature>
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            <begin position="253"/>
            <end position="306"/>
        </location>
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            <begin position="582"/>
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        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI69688.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A7D5Z8Y6</accession>
    <name>A0A7D5Z8Y6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g064140</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028992253" evidence="1">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="242" mass="25837" checksum="EA2FE1A9D075727D" modified="2021-02-10" version="1">MRPILSPLLLALSSLPFSRSALCVLSWNISYVPPGGLRDISFPINLSRAPHVAGYHFAQRVKFYGQTSVAYAGLQPRQDTSSGATVLRGVFTSFINGTTTTDPNCSEGVDDGPGVSCAHDFSGSHADTWDLIMTNTAGTTWAGKAVNYKNGTAFHIGTWTLPEGTGGIQGSQVGFMDYFPWNTNFSMTCADLPPTECTFSPPTTGSSWNGYSVGSISGSVERCENNVDHGPSLNGGWRFAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAC9</accession>
    <name>A0A7D5ZAC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690539.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26240448"/>
    <dbReference type="KEGG" id="mbrn:26240448"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="296"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
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        </location>
    </feature>
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        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="41868" checksum="4FD450380AB211A8" modified="2021-02-10" version="1">MNQLSPQRSCITEDQKYQGALYKEKNKKPKINNHKPDDSRYQHQYDRPKNMALQPYVEDMGEDGAYEPWNDSIGQTEDEPSPAEGLPEAPTPPPAATDHHINVFDYLIATGQTPNASNMNLVMDQQGPETGDGKSLVRYDGEPLVQYGSGPVPTDAAFVTPSSKTERRRSREREPKKDKKRKRLHVDVPADRVMTDAPPVMHSGLTGSLKEMMRHTYPPSPDYSGGDVGGNSPASPLKKSKHSKHSKGGGISDGLFGAMMNKSSKKKSKKHSHRHPEHRDTKLIEYRPQSKDGKTGEGQVVVYKPRADAFLSLVNKGPESKKGCSMKKALKQFHRVRQDSGSNLPKATEEKELWRNLRLRRNDRGEIVVFTAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAD4</accession>
    <name>A0A7D5ZAD4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g109570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543899.1">
        <property type="nucleotide sequence ID" value="XM_014688413.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
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        </location>
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        <location>
            <begin position="91"/>
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        </location>
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        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="40480" checksum="AA04BCEC98A6027E" modified="2021-02-10" version="1">MEPSPEPPRSAMESASASACASASTYATTVDAPPESSIATAHLARFEFSDLGTKILMVEWHPSSAAVASSSSPSAHSSTGADHNTETDTTVAADADPTTGGTLAVTHAPSTPLAPKPAPNTDAAPIPGAQAIKNRDSVSAADATVWEVSWPGKSTFLPARDTDQDEVGTRRRVYFLLPPEASIPTNVTITPPGQPSILVKPLPAIFPPGFNVESGTRGVLHTLWAKKRLSELQCEMDAEMRANAESVGLEMALTEKQWIIDNFLPPPSSPAPMSPRSSVPGRLGDKLKGLRLATSPEDLMPSATANTFTGADVPSQTLSPSGGDIAVSSFSAISRGNGLTQAMSLNAVMQGDTPAIDLSSRDDDDDLFALPLSPRSPEMKRSPFSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAQ0</accession>
    <name>A0A7D5ZAQ0_9HYPO</name>
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        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g079300</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
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        <location>
            <position position="61"/>
        </location>
        <ligand>
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        </ligand>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI71349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="46809" checksum="2CF6EABD31F0EC97" modified="2021-02-10" version="1">MYPDWPESDADLVPLPRCHGPKLKPFDFQGPQKIEFLDYIGEGLHAHVFKIKIMGKIYALKLFRFVYDGDWMSPDYEGLYATASLEAMSAFYEYSEPFSSECRAFGRLQEAGHEELAVRCFGYLLLDEQHERAITDQFSHHRIRFNGNVDGPLASDELRSRFLGKSGRLPPIRGIVKEFGHLPQALRTRDARRILQHVTQLHQLGIIYVDVADRQLINHKICDFSTAITTPHYVTNPELNPLIAPEWIPAMEFETFQFSISDYWSFDDMVQLWNAEHKDQKSKLAVYAFPGSRGYPTKYNLRNTPSRERVFSFVDPRLYDWRRPAASPGNKATRASDRQRKRKMGSRRADPKTRVRLDAKPPKWYLDCNDQVTANLKLGTAGRGWTTSLRWEFRDGRIFPRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB56</accession>
    <name>A0A7D5ZB56_9HYPO</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691279.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26241188"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="338" mass="37180" checksum="9BF351B8692BEA27" modified="2021-02-10" version="1">MDNDTSDAVQHDEQQSTSVHRRTPSGSGILSKFPFMRTSAEIKTRLDIEEEDTINSVATAPSSLAPLTQLQKTRRRRGSLRKAALLGRGAQREKKDTKLLKIDTSHTAAFGAGVVGASSSSTATERDALGLKTSDFTLHTVSTDMSLQNSATSNQSGVNAIANGGHGEQDTERRNSYNSTTDEEDVLHISHNQGPPLSTLSVSSGSESYYTNRTTAPRRRSFQQTKSPLSYSGISTTALPHPDSDWDYSETEWWGWVVLTVTWFVFVIGMGSCLNVWTWAWDVGKTPYAPPELENDETLPIVGYYPALIILTGVMAWVWVVVAWVGMKYFRHAKISGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBH3</accession>
    <name>A0A7D5ZBH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpb7</name>
        <name evidence="9" type="ORF">G6M90_00g099210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546425.1">
        <property type="nucleotide sequence ID" value="XM_014690939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBH3"/>
    <dbReference type="GeneID" id="26240848"/>
    <dbReference type="KEGG" id="mbrn:26240848"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="171" mass="19224" checksum="264C1F0A6DB41E09" modified="2021-02-10" version="1">MFFLYNMERRVTLHPSYFGRNMHELVTSKLLKDVEGTCAGSYYIISIMDTFDISEGRILPGNGLAEFTVGYRAVVWRPFKGETVDAVVYSINPQGFFAQAGPLRLFVSAHLIPSDIKWDPNATPPQFTNNEDTVIEPGTHVRVKIIGTRTEVGEMWAIGSIKEDYLGCLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPG1</accession>
    <name>A0A7D5UPG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g018010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985586.1">
        <property type="nucleotide sequence ID" value="XM_066129809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPG1"/>
    <dbReference type="GeneID" id="26238176"/>
    <dbReference type="KEGG" id="mbrn:26238176"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="346"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="790" mass="86414" checksum="242C4885710759DA" modified="2021-02-10" version="1">MMIESSVLSRLYSPGAVCSSQDPARLPISNWSREQYGRCKIGGRDEVDIQETGLEPHPTEAHLSSSSSTTSLSLSPQPWDVEAPSDLRFTDVAHERSAEAPPGLGGLCEMSKAQAGTRPCVHCTRAGVECVPRQGDAQEHRPLPTSSTQPASSRNDEADNAPADTTVVLPETSIVDLSTMIFARMQQDRHVGHDSSALPGGHKTVHAQLLRGRHWRQIVEWELPPDDVLETFVDRFFVSVDWFMMVFHEQSFRQSYARLVASQQVSYHEENFLWLSMLVLGLGAHYSSVSPSASTAGLDLEQLSRTLLASIELRFLQIIGCSTLEAVQICILLGSFHLFNGRPNAGLGILGSSVKIAQVIGLHRESMWRDTSEAVKEAKRRTWWALEVFDKYAAIAFGRPSSIDDSDCQVAMVSALPLGSPRRAAADTPTDTEPLLLYHQWKFPLYRIMGPFLGRRLQTKRLENVTSIHGQLIQWREKLPDRLRIESYATASRQISLLQMQALSLQLTYDNLQIILHRSAAFRVADGGASRVDATSISSPFSHRQLFEAAIRTADLHRYSHVLQECRRTHANMHIGITLFTAGVVLCAICLSQPMSEVSQRAKTGIMHIIRICHDNSSAQHLVSAQCVKILEGLVAVILQAENQLITGRPSAPPADELASRAEASGGGERSRPVSDGRDTTGQSTVVGGRGAAGVLDPLQEGVFERHVQRPAPPGDAQGDPQPGDDSMGRHQTRGAESAAAPVADPGAGFDWDGDLSLLVDSGLGDASQLWLWADNLNYDSFAEFNDAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQL2</accession>
    <name>A0A7D5UQL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g015470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548980.1">
        <property type="nucleotide sequence ID" value="XM_014693494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQL2"/>
    <dbReference type="GeneID" id="26238424"/>
    <dbReference type="KEGG" id="mbrn:26238424"/>
    <dbReference type="OrthoDB" id="4941489at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="108" mass="11479" checksum="3B410459D0196CB4" modified="2021-02-10" version="1">MNNSGSSRAPPPPPLNLASLPPVKFNLDKTKTVDSEVVSIPSSSKRSASYSSSASTFSGQSSSQKTSSSFIKSSPTVNVHTTCGRHTDQYIFGGPSLRDLAKSIKKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQR9</accession>
    <name>A0A7D5UQR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PUS1</name>
        <name evidence="18" type="ORF">G6M90_00g017480</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548782.1">
        <property type="nucleotide sequence ID" value="XM_014693296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQR9"/>
    <dbReference type="GeneID" id="26238226"/>
    <dbReference type="KEGG" id="mbrn:26238226"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="400"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="308"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI64416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="603" mass="68228" checksum="590B5B53E6ACED0B" modified="2021-02-10" version="1">MAAGDEHSAETSGPAVERNASAANATPGNTTATESGDATPCQKPGDNHEGKKRGEKGRAERSRQLKNDKKRKKQDDWREFKRRKLSDKAGESGNSEKKNPFSQEEIASEERRPKRKVAVMIGYSGTGYKGMQVNGDEPTIERDLFRAFIDAKAISKANADDPRKSSLARCARTDKGVHAAGNVISLKLIIEDDDIVDKINAHLPEQIRIWGIQRTNNSFNCYQYCDSRFYEYLLPSYCLLPPHPQTYLAKECEKLNKEYGAEDEVAAVMADVQDFWAHVEEKEIKPILARLDPELRAVVMERVHAQEAEEYENNKKAEAEAEQDHAPDAGAADKPDEAGDAATRPEEPKRVSLESHKPKHRELAPIDFALRDIKAAYIAAKRRYRVSPERLQRLQRVLDKYTGTYNFHNFTIQKTFSDPSARRHIKSFTVDPKPVIIGGTEWLSLKVHGQSFMMHQIRKMVGLASLMVRCGTALDRVADSYQEQKMAIPKAPGLGLLLERPVFENYNRRARDTLGKETIDFGKYEERLEAFKQKHIYSRIFEVEEKENTFHGFYNQIDQFKANHFLWLSAGGTKVAELNKESDKTEVDKALGDEDENPEGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URK6</accession>
    <name>A0A7D5URK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">qa-3</name>
        <name evidence="2" type="ORF">G6M90_00g005220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542169.1">
        <property type="nucleotide sequence ID" value="XM_014686683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URK6"/>
    <dbReference type="GeneID" id="26245200"/>
    <dbReference type="KEGG" id="mbrn:26245200"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="35988" checksum="0D5DA362F22E5881" modified="2021-02-10" version="1">MATTEALQQQKPLGDTLEDQKTRLDRHGYLFGQKITHSLSPFLHQIIYDHLGLKWSQIRLDSADMSQFLQLAQHPSFYGASVTMPNKVAILAHLDEMTDECRDVGACNTLFLKQRNGHRILCGTNTDVVGIRDSFHHNVADPSHTFHGRPALVIGGGGAARSAIYALRKWMHVTDIYLVNRDKSEVDAMVADCSSRGYGHGLRHVASVDEARAVDGPGAIVACVPDCDPRTREELVARQVAEVLMDKRHKGAMLEMCYNPSPFTRLGALAGERGWQVILGTEALIWQGLEQDRYWTGLRIDQLPVAKVQSAIGEKVAQRSQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US08</accession>
    <name>A0A7D5US08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pph-1</name>
        <name evidence="9" type="ORF">G6M90_00g024350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985939.1">
        <property type="nucleotide sequence ID" value="XM_066129938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US08"/>
    <dbReference type="GeneID" id="26237590"/>
    <dbReference type="KEGG" id="mbrn:26237590"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="174"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="369" mass="42161" checksum="C12C3B8CA87E82E3" modified="2021-02-10" version="1">MDTNMEDVGRAPADVSPVANEPATIPTLDGWIESLMNCKQLAEADVQRLCDKVSNIEEFKEVLAMVFGFVQCLASILPDPLFMLGAILLLLSWQEKFYRRSRMSSQWYKCPVTVCGDIHGQFHDLMELFKIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVALKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDNIRALDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLIARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USM1</accession>
    <name>A0A7D5USM1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g004400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542090.1">
        <property type="nucleotide sequence ID" value="XM_014686604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USM1"/>
    <dbReference type="GeneID" id="26245121"/>
    <dbReference type="KEGG" id="mbrn:26245121"/>
    <dbReference type="OrthoDB" id="4838114at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
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        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="44229" checksum="460742BB19DBE6A5" modified="2021-02-10" version="1">MSLSEEPTYGAASIPAQQSTEENAATKENQTQRLYRNSLPSSSDSPSSQLPLKGQPHLPRTESNLPVAAESETGARKQKDQDSSSDESNDTSSSNSSANGKDDDDMLSVRDLSSSSTSSLAMPTGDVPALPAKSSLRASRLLASIPQKRAPNDDQPMLPHAAPHQVYLSSEEDASSSADDFSDFDDEMESDGEGGSQKPSTRNMAREDTARVVAVVFHGKPSIVTLSPRRSISPSSSEVGQPGTGLLRTATEPSLQHQRPRSVSSATSVMKFNHPPRSSSMTTGFEKKRPHFLHIDPYAKVRDEAAEHLRGPMTPTSMFRRTLSLVKKRSKPNLHQSESQLTPMEKVGEVEEEEDPRESLCLEPNSVGPVSNQRHGSVSSPRSEASSPISPKSRFRTGLSLGRQRSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USN8</accession>
    <name>A0A7D5USN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic expression up-regulated protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">meu26</name>
        <name evidence="3" type="ORF">G6M90_00g018680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129824.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26238116"/>
    <dbReference type="KEGG" id="mbrn:26238116"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF3">
        <property type="entry name" value="TRANSCRIPTION REGULATOR RUA1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="2">
        <location>
            <begin position="397"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
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        </location>
    </feature>
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            <begin position="499"/>
            <end position="509"/>
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            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="609" mass="67182" checksum="B26C8336C71AC608" modified="2021-02-10" version="1">MPGNDGMLPGGTMWMSPPTSEPRKRPAAIYTNIAYTSGDEMNPISAWSGMHLQQVTDPSTSRSSPITQEMLPLAMSGHDEWNQPSCGEVIDFHGLDSEGAIGQAYTTDEAVPIIDLRYSNQSQEAANLNMEDGIKQRRLSNSSLTVSTSEPMSDIPSSYEDYPAGLSEAPSYASDYLSTASNRTSLMSSIQLSPVASPRATPQSRPEQVRTQSRGRASPSPRPSVRSAPYTLETSKNQRWSTGSYAPTQNRRQSPMIFHGAQDGYATNQRMSLQNYPPLMPAQSFHPGGIQGHPPHQPPFVVSGQPMFARHGMIPPAHMPHQGMFEQPPPLPSHGIFKMLQSNGDPHMLHGHYTDLSDPPDLFGPLAEEQVPPPEEDMNHSDPNMIPYEQDLRFDGDLYTPRWVRGHGNKREGWCGICKPGRWLVLKNSAFWYDKSFTHGISAATGHPFEEPLDTRRMDGNPDVWEGLCTSCNDWVPLVSSKKKGTTWFRHAYKCHTHQKVKDMPKRRREMGSSSRKLAAQTPKTKLDATVQQPMTPQSVTTPVSGLHTPCSVPPLMPQLHLQVLHHQQQMPPHTEPPASVSGPDSMCLSGGPPPISMPPSTSIMGNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USR8</accession>
    <name>A0A7D5USR8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g005810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014694437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USR8"/>
    <dbReference type="GeneID" id="26239367"/>
    <dbReference type="KEGG" id="mbrn:26239367"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="502" mass="54800" checksum="DF4B67F5D385C5C9" modified="2021-02-10" version="1">MESSPIVKAHDHAAAAAVATRQSADTTVAINEHTLAAGEFANAARNTTSVEALRTLKLLEEHHRRLAELLNLQPDPVSQTSEEDVNEKTSLDEKGASTTHQSGKKLPSLTQKGFTAREMSSSIASNLASARGIRSKYRGQPLSPSVSNDQAPGNVDPHPRRDGSRTKMQSIIDTQPGKPTWVPPMAPHKTEPRTNKSAASSPRIDQTTASAMASEDAGYARFYNSFGSLINKISAPLAFAGLPLIQEEPTPEQPTTEQPVASSPPKRRASRQPPTSLALDPDLSKIYSKATMRALAREGHSTNDSFYVVPTTGHTMSYANILTYAEKEKRRLGASLHSNDPEDEDDDFVDARETPVPVSPGARRRIGLAHKTERDLRNTIEELSLQNRSLKDTLDVVSKRLHAFEASSQNSAMALAESYRILRPGSPSAAPHAPNAAGDEALRKKTLNMEEQLAAATKQMERLEKDNRKMQKTLDKYREKWEVLKAGAKARREGKSGEGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UST4</accession>
    <name>A0A7D5UST4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-U4-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CYCU4-2</name>
        <name evidence="2" type="ORF">G6M90_00g017200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UST4"/>
    <dbReference type="GeneID" id="26238254"/>
    <dbReference type="KEGG" id="mbrn:26238254"/>
    <dbReference type="OrthoDB" id="5304883at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38900" checksum="F1F95F16DBC08B12" modified="2021-02-10" version="1">MADTDHQPAATDHAQIQRDASDAAARAAIPPSPPMPSSDPGLAIVDHDGSAADQDDLFKLPAAEALRLLSASVELLVLMTGDIPPTPPPKTPTDPQMTGMQVEKDNMVRSRSQQSLANARQQAERAAAHRQHGDAGEATSGIDRLQAYSASMSAQLAAQQHASAMPSTSAEPIDGVRLRQHPDADAEPYIIVGADSRPVNLQHGAITRKFYSKKEPPIPISQYLLRLHRFCPMSTAVYLATSLYIHRLAVEERAIPVTKRNAHRLVLAGLRVAMKALEDLSYPHAKVARVGGVSEVELARLEISFCFLAGFELVVGEEPLRRHWEELRDGRAQQALRGMDVPTLKLSKRPREMAQASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USW5</accession>
    <name>A0A7D5USW5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g013770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986088.1">
        <property type="nucleotide sequence ID" value="XM_066129749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USW5"/>
    <dbReference type="GeneID" id="26238589"/>
    <dbReference type="KEGG" id="mbrn:26238589"/>
    <dbReference type="OrthoDB" id="5369729at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1133" mass="119987" checksum="D1E5BC8A0C8E414A" modified="2021-02-10" version="1">MTESAVLTTAAASHHHQHQRQTSAKTNANASKHRATVSAALSVGASLSTGTRSTEPANTAVARGSLYGRGGRCTGPGTGTSLSSPNVPGASMPSVQVPATALEDSTPTLNAHPTCRASTMAPSAATATSTSTRTTSSVTSIPHSGPNEQNRPPSSPPRAAATVAAGGHHLDNVHADDSPPLTRHSHRQYNTSSKLPPPRPADSRRGPPAASSFPSQPHRPHHSHPGQVPPSLHGAPSSALPNPVPEQRPAPSIPDNIANTGAAADANADANADAGREAESTTHHHPSSPFAVSPSATSPPRPAVHSRASSYHASPQPATSSSSDSPPAQPKRPASCPESGPDHADQTTSPSSLSPTGTTKPLSWRGPASRSSNGVSTSDGPPPSLNTQRLHGVEAVAQTTAQPQPLPETPRTKSTQGQRELLLLNRLSGSSSSDDNRYPSPQRPPVSYRPTQKRHSIQPATLTPGRVPPIRSFRSSDSRKSLTQDMNPMSRPHDLGELYATSPEEQSPHSFEGRHAQGGVSLNDGESGRQDDGGDVFLRIARDEQMRRLRGDENLDDAQSSVSGIRRSSHRRPLSTVVPSYHHQASPPRHRRRLSDQQDRPRPLHLEDDQGSEISRTTTFRSLLREKAASVHPGEEIPRTRSGGANLRPSPLSARSTVGYDNSQEASIYARRRASITDSNSTVGRTPGYRPSGLIQARNHGSSPLARTIDLQNKTATEAPHGLEGTESTASTTAPSTVWDELDDLKSRINRLELTGKLPSTSGAAVSRMSEERPATATTTVTTLSGSPKRQVNGQIAEVSSTTSSQREAHPILHEALVKSRPYLSLEVYQALQSAANDAMALSSMMGTPALGEAVGPANIAGPASPPALAQHDGPATPTAPKSYSSLPTPRRVAEHGIPKSISSPRPLSKFEERRSSILNGTALPTPRATGSAPTTPIEGNSQRRSSLMISRTRRAGTEEPEVARSPTMLRSRRAGTEEPEEGRQTSFLRNRRGTVGDDGGEGRFRPPSRADTDVNMLRDPGREYPSDSPSIAPDSISQIPSALPRRRFLSTSVYSSRPAGSQGSNIASPRRYNDRQAGEQDFGDSVGESRAQRQGPPLSKGIIHSRASSLSTRRNRDSLISTSSGATIGPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT61</accession>
    <name>A0A7D5UT61_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mycophenolic acid synthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mpaB_0</name>
        <name evidence="2" type="ORF">G6M90_00g006500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549856.1">
        <property type="nucleotide sequence ID" value="XM_014694370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT61"/>
    <dbReference type="GeneID" id="26239300"/>
    <dbReference type="KEGG" id="mbrn:26239300"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046366">
        <property type="entry name" value="MPAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="49149" checksum="AD3540902BA5E1D1" modified="2021-02-10" version="1">MTLWRTMFVEFLSSCATLWALLNKLSWPAIFLITLILYVLTCSLLRFRSLRSMKSRFNFPDRASLARMTGSEAQAIIEHAYTYEFPLFFGLSLAYAQMKTYAIQNIAKLLAATGNLSKQSKVSKRFEDTALIFACFMLFPPDSPQLHGAVARMNYLHGPYIRSGKIQNEDLLYVLYAAMSEPVRFIRLYEWRELSMFEIAAQGTLWKTVGDMMGINYTEALGKDNWKDGLEFMEQVEQWALHYETDRLRPSHPSRQLANAQLDLLTSIFPSFMRSLMRQMGLVMMGDKMRCSFGFPEPSTAISALTLTLLWLRQIMMRFFMPPRPTSRRYVTDPDPITGRMYSTHYVKEPWYNRPTTWARWGPAAWATWAFGGMLPGDGGQEMKPDGFLFEDIGPKAKMGLGAEETRNIQEVVHAAAMASGRCPFALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTH8</accession>
    <name>A0A7D5UTH8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional activator of proteases prtT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prtT_1</name>
        <name evidence="8" type="ORF">G6M90_00g030390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539459.1">
        <property type="nucleotide sequence ID" value="XM_014683973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTH8"/>
    <dbReference type="GeneID" id="26247733"/>
    <dbReference type="KEGG" id="mbrn:26247733"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="668" mass="73868" checksum="050C3BF27D309100" modified="2021-02-10" version="1">MSKRPIASISTAQAADREAPSDASENAHKNPRPMSSSHAPPHASSAKRRVTSCAACRKQKIKCELLTERPPCERCKRRNIECVINTGLRNSILDQRQLAVLGRDLSRVHATLETVCQQLGVELPKPLELAALSSVGTGSGMQDGDVDDGEDGLYEPSQHNSPSAVPAPIDAYLTKPESEPSAPGPATASAARSYKKPDIISKGLITIEDAEVLVNHYFVEMDPILYGFVNTHSTTHGVRDGSPALIAAICTVSSLHLVDYGHLFETCYREYRHIIATALFERQDVEHIRALLVGSFWLPGASRILLCDAVRRAGDVRLHRHIFKAINGLSNTSPSLHHGGADQDQSRDCVRLWYGIFMSDQHQAILNNRESLLPLHIDVLEKRGEYMDNEACTGHDLRLVAQSSLLLAMARIKSTLGSEYPTPVPESRAAEFVNFSAELDAWIDEFRPKFQPSPEMGKFPPLAFQLHYLFGKLYLGHHVFRGLQGRMIPEALLEAARMAYDAAVAIFRMILDADGLLCNLWRVPGYIHIMISFAGHLLLELCIKHRDQLEINVEQDYRMLNAVVSALTNIRLNPAHPLRRVASGLQKRLFEFAAQYGKQSLIDNGTDWPRQHGKEATSMTASASAGGGAQETTRPLFEMGATGMPDDFFLTDFSDFTFQDPSVDFMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUI8</accession>
    <name>A0A7D5UUI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-erythronate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">denD_1</name>
        <name evidence="4" type="ORF">G6M90_00g030350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539455.1">
        <property type="nucleotide sequence ID" value="XM_014683969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUI8"/>
    <dbReference type="GeneID" id="26247729"/>
    <dbReference type="KEGG" id="mbrn:26247729"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="315" mass="34207" checksum="CDB3EB93A654D634" modified="2021-02-10" version="1">MKILVTGAAGYIGQILSEALLNAGHSVVMADIVEPLVPPGAKSAQDRATLVQVDLFEDAESVIGQDLDAIYILHGIMSAGSEADVDLGYRVNLHSVLKLLEAVRRLCPGVRVIYTSSIAAYGSPLRGLPSEDTVCTPQTSYGTHKMMIEAVLNDYNRRGFITAFALRLPGISVRGGKPTQAASSWMSGIIREPLQGLETTIPCGDDFKCWVCSPRRLVKNLTIALTLPADCMPPHIRQVLLPGIAVTVREMLQVLRNVGGDEAVRLVRREEPTAAIRAMLDSWPTQFDDAKALRLGFVPDQPFQDTVQDFADSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUQ6</accession>
    <name>A0A7D5UUQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g036170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547010.1">
        <property type="nucleotide sequence ID" value="XM_014691524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUQ6"/>
    <dbReference type="GeneID" id="26239573"/>
    <dbReference type="KEGG" id="mbrn:26239573"/>
    <dbReference type="OrthoDB" id="5396420at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39603" checksum="81BDA01AA98324C2" modified="2021-02-10" version="1">MPGSSATEPLLIHMPPFPQPDGSASKLPTFLGKRPVASINYRWRPFSEPSPEVSTVNKVFSPLYWPTPVHDTSFAFAWLIENFPPPTHKRRDIYIYGSYLGASLAASLALTEAHTHARFGVRGLIAYNGIYNWTMFLPDHRINRPPKRAKATTAPPGPQEGSQLHRLQEQMPALFDMPSNLFDPFASPSLFFHSPGLIVPQSFFMTVEHSALIDNMTSDEEITPNPIKSPRKSHLVFPPRQSTLKIPDTLLLFDSAALPVPKPTTKPKSARARKRAKPKGHSFEAQAAELAELMRRSVNVVELKERSKWDEDVHSRVDEAIRRVRVVDVGLERDSTELSDVGCDAVTTWLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUZ6</accession>
    <name>A0A7D5UUZ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Plastidal glycolate/glycerate translocator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PLGG1</name>
        <name evidence="7" type="ORF">G6M90_00g047440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544862.1">
        <property type="nucleotide sequence ID" value="XM_014689376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUZ6"/>
    <dbReference type="GeneID" id="26242203"/>
    <dbReference type="KEGG" id="mbrn:26242203"/>
    <dbReference type="OrthoDB" id="2502820at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249:SF0">
        <property type="entry name" value="PLASTIDAL GLYCOLATE_GLYCERATE TRANSLOCATOR 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PUTATIVE SEROTONIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="533" mass="56758" checksum="F7F9801D11AB074E" modified="2021-02-10" version="1">MPHRDPLDPSNSTWRAYVRDALVALKLTLLSSRGKLLRDWVFVPLGIFAILGVCYGVDTLFRRVSVSFPASVACLALLFVGLLLCEAVLGTHATRRAVGVISVPADWSLRWIGLCFTPSFVTIPLSPAIGVGEVFKIIAVFGGGAVVGFAIMMVLAAYMTRGLQLVLGATKRSEIVDRGDDISRRGHDEMPLHQRRADSDDIASPPQLRLQQHHYSQSSTAESSSSSLPDYPAQAPPPPARCALYAARLASHLDASIFALVLLAGIPVYYASGYAMPLHLAVTTLCYRLALATPGPWQRYLHPVLTASLLAVLVIWPLALAHGSGLTAALRSYKTGANYTRLWRREPGPPLLPGAGDVFSTVLDASIVSLALPMFQYRRELKRHLATLAIPNVLISVGSVLSYPPVCRAIGIAPTRSLAFASRSLTLALATPATANLGGDAHTVAALAIASGILGVLVADKMMRLLRIPDDDYVTRGITLGVNSSAIGTALLLRTDPRAAALSSLSMTLFGTVTVLLTSIPPVATMIRALVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV81</accession>
    <name>A0A7D5UV81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g037800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547140.1">
        <property type="nucleotide sequence ID" value="XM_014691654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV81"/>
    <dbReference type="GeneID" id="26239703"/>
    <dbReference type="KEGG" id="mbrn:26239703"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68134.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="66244" checksum="2BB0CEE88841182B" modified="2021-02-10" version="1">MGCASNRKKQTREFLDQKWDYINLQDFRAKGCGPGFAYGYLWFMLIISIAVYAVDSFTAVNLLAFDQWSSKIEPAIPFNVSKWIFSICILLSFVNLAFEGVRAFRVMRRGNVAECFLDSLAVRWESIRFGSGQGWRRFLVFAELTKSKKGSEYVALFTYFSFKSWIRVIFCSGPRQVVNALTLRSVYVAKLAPTATSVDGAILGFFDKVKVLASEDYQQAVILSGMCFTLVVWVFSALFLLMAVFFYVFFLFHWIPRADGGLSGYCERKVNKKLLRIVTTKVNKALAKGQADRFKAELELAKKSGEKVPYLDRAATLPTLPNVQPGMDDSLPRMPTGWQDEKATIVQMYASSLGSPGSIELSSIDGRRPMHRTGTSGSGSSYSSRAPLVSSAADMAYGPPQSLATGLPDFDLMSGMGPPARPGTSNSQRSFSNGRPGYGHVANGSTGIPLRTITASPALTERSLPAYPGLMRTQTNGSMGSNYGARPPTSRGNTDPMGFETSSLPYPQYNQYNPYDGLGGREMPAPSYGNSGGPPPPVRSVTGPAGQIVPHQEGAQYYPPQRNMTSPMPLRGYADGQPQGMSPGYHIEPYGYDVESQQNRGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVC1</accession>
    <name>A0A7D5UVC1_9HYPO</name>
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        <submittedName>
            <fullName evidence="7">Transmembrane transporter swnT</fullName>
        </submittedName>
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        <name evidence="7" type="primary">swnT_0</name>
        <name evidence="7" type="ORF">G6M90_00g032280</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687677.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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            <end position="446"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="488" mass="52768" checksum="1D203DE806695C46" modified="2021-02-10" version="1">MAKLGTMPPQHAAKPVDEHAAHLIREDNVPIQTQKPFTTLSAIGIGYGVTNTAVGIPLILSTAMAAVGLAMAAVGLATATTLAELVSAMPHPGGQYIWVNALAPKRYRRGLSYTTAMISWVAAVATGSSGNLSVPLNAFSIVTLLQPDFIYRRWMGFAAFQAINVVTCFGACFEHALPKLSKAFLLFNIVSVGVIIVALFAMADARTSAKDFFTTVNTSGWPDGVAFIIGLNGANWCFSCLDVATHLAEEIPSPGTNIPKALLWTIFIASTSGLLVVLAVLVNLGPVDVSDYSGIGIFYRITGSKAAAIGLWIPVLILVLASVWSIQTWQSRLAWTISRESGFPLHRHFSKIFPAPFYTPIWSLVGSAVGTALFGCLYLASELAFNSLIATGILLQYISYSIPTVLVLWQGRGNFRHGQFWYPKLGLVANFIMLAWTVVAFIFYCFPANAQVRPSQMNYVSGVLVVIATFIAALWILYAKKNYRVMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVN9</accession>
    <name>A0A7D5UVN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cct3</name>
        <name evidence="11" type="ORF">G6M90_00g048560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544971.1">
        <property type="nucleotide sequence ID" value="XM_014689485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVN9"/>
    <dbReference type="GeneID" id="26242312"/>
    <dbReference type="KEGG" id="mbrn:26242312"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="540" mass="59304" checksum="186E43433C2BCB75" modified="2021-02-10" version="1">MQAPVLVMNTNSGERQTGRKAQLSNIAAAKTVADIIRSCLGPKAMLKMLLDPMGGIVLTNDGHAILREIEVSHPAAKSMIELSRTQDEEVGDGTTTVIILAGEILAQALPQLERNIHPVVIISAFKRALEDAIKIIDEISLPIDIDDDKAMNQLISSSIGTKFVSRWMDQMCELALQAVRTVTWETGNGKTEVDIKRYARIEKVPGGEIEDSRVLDGLMLNKDITHPKMRRRIEKPRIVLLDCPLEYKKGESQTNIEITKEEDWNRILQIEEEQVKAMCEAIIAVKPDLVITEKGVSDLAQHYFMKANITALRRVRKTDNNRIARATGATIVNRVDDLQDSDVGTRCGLFEIEKIGDEYFTFLTKCQDPKACTILLRGPSKDVLNEIERNLQDAMGVARNVMFHPRLSPGGGATEMAVSVRLAQLAKGIEGVQQWPYKAVADALEVIPRTLVQNAGKSPVRVLTDLRAKQAEGKSSWGVNGDTGTIVDMKEYGVWEPEAIKLQSLKTAIEAACLLLRVDDICSAKKAQLGGAPGVGGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW31</accession>
    <name>A0A7D5UW31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATP25</name>
        <name evidence="10" type="ORF">G6M90_00g046060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544733.1">
        <property type="nucleotide sequence ID" value="XM_014689247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW31"/>
    <dbReference type="GeneID" id="26242074"/>
    <dbReference type="KEGG" id="mbrn:26242074"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="604" mass="68181" checksum="D2249497DF0AC328" modified="2021-02-10" version="1">MGLRSTLQIPRLPHRFFSADRSIPSSSAQTQTQDSTNSNNHEEPQERTVEAESAADNPWFLEVEPPRHPPSLHAPFVPNAPNESPELIAPMIKYIFEDMGLDDISLMDLRDLDPPAALGPNLIMLFATARSERHLHISSGRFVRWLRRNYKVDARADGLIGPGELKTKLRRLRKKAKLMGTNTMILPGGDNGISTGWVCVNFSTSDKVSDETVSYDESGRFSGFGASPTGTTIVVQCMTEPRRNELNLETLWQGMLKRNLEQTMKIKGQPIQDQTELETLVSSKIQLPDNSSRVQWQKLQQASQQQRFFSTNARRLQSQDYAAASSENKEPENPSLAAEPEDSELKTLQRRITDLHISGTSLSQQVLERLISAAFHASHSEGDASTRLDLVDQLLQTAEERGISVQSKDMLVTLIESIVTSAAYGPELERAQSNLEFLLLNLQTPLEHGQTLRLMRAYAERQAWDRFWDTFRAPARFQIARPGELYELAYRVMVSTQDARMCIDALRWVYPEMLKEEPPVYPTGPVYNALKACILVADPAAEEMLHNPPSMDSLGLVGRRRLQHREFVRVLREVEDAHRHLLGTQAREERAQALHRFTDGNTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWC4</accession>
    <name>A0A7D5UWC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like F-box</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g030200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539733.1">
        <property type="nucleotide sequence ID" value="XM_014684247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWC4"/>
    <dbReference type="GeneID" id="26247490"/>
    <dbReference type="KEGG" id="mbrn:26247490"/>
    <dbReference type="OrthoDB" id="4540290at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028908683" description="Cyclin-like F-box" evidence="2">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="37430" checksum="88DA4846E911A2CF" modified="2021-02-10" version="1">MFKPKGTGFLVLCALLILCICFGEAAPQRKQGKQSGNKGGKGGGNGGGNGGGNTKQTLQQQAAQKPGGISKAQDGSVILDKTVKINGLNIRYKVSAPADQFKAASGVKSGNAARAADTEGTIGMNVLLHGDGGDSFFDFPNEGVNANLMGVAVLAPDKNLKWGGANQGKQQRSQGVPHSKAVADLITQELPKMVAFNQSNVWFTGVSGGALTLSGFFIPAHMGQFPNTGVLLNCGGLPPQVNFTPEAEAAISNTRIHTQSSQKELSSLQKTIPAAVKAYEDEARKARLNTQQINALQTVDNTPSGGHCDFDGKGFTSGVKSVVTKFDQIMFPQGNGQVNGVDVKTGVIGNEALRFTGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWK3</accession>
    <name>A0A7D5UWK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g046040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544731.1">
        <property type="nucleotide sequence ID" value="XM_014689245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWK3"/>
    <dbReference type="GeneID" id="26242072"/>
    <dbReference type="KEGG" id="mbrn:26242072"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27713" checksum="87401EE763833AEA" modified="2021-02-10" version="1">MGSSSALRLAILECDTPQPQTRAQFGGYAGVFTALLSSAAKTLSPPQDLSKMVTITAHDVVNDLYCYPALEDVDALLLTGSRHTAFDNDPWILKLVDFTKRALETGRIRVVGICFGHQIVGRAVGAGVGKSDKGWEVAVTEVDLTDKGKEMFGLDKMRIHQMHRDIVQNFPPDAIPLGGNAFCPVQAMYLPGKYITVQGHPEFTNEIISEILFNRHTVGIFTDEVYEDAIKRAPVPHDGVAIGRAFLKFLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWQ8</accession>
    <name>A0A7D5UWQ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cyanide hydratase</fullName>
            <shortName evidence="7">CHT</shortName>
            <ecNumber evidence="2 7">4.2.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyanide-degrading nitrilase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Formamide hydrolyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cht</name>
        <name evidence="9" type="ORF">G6M90_00g064870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>formamide = hydrogen cyanide + H2O</text>
            <dbReference type="Rhea" id="RHEA:21720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16397"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="EC" id="4.2.1.66"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Oligomer of dimers, forming left-handed helical fibers.</text>
    </comment>
    <comment type="induction">
        <text evidence="7">By cyanide.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.66" evidence="2 7"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540057.1">
        <property type="nucleotide sequence ID" value="XM_014684571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWQ8"/>
    <dbReference type="GeneID" id="26247093"/>
    <dbReference type="KEGG" id="mbrn:26247093"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030196">
        <property type="term" value="F:cyanide hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019500">
        <property type="term" value="P:cyanide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03224">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037544">
        <property type="entry name" value="CN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF4">
        <property type="entry name" value="CYANIDE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="39808" checksum="677DC63C31697680" modified="2021-02-10" version="1">MVATIRQYKAACVQAEPGWLNLEKAVKKTVDLILEAGEKDCKLIAFPEVWIPGFPYWLWRVNYQDSLPLLKKFHQNSMRPDSDEMRRIREAAKAAKIYVSLGYSELDGHTMYMAQIIIDPTGTVINHRRKIKPTHVEKLVFGEGSGDSLHAVVETEIGNLGHLNCWENMNPFLKALNASKHEEIHVAAWPVYGPGSAIKYPDPYTNASEIQSDHVTPAYAYETGAWTLAPTQVVTREGARLGLPVRLQNDEAALDGEADIIGNGYSRVYRPDGFRAVDDPAKTFDGLVIVDIDLDENLLTKKIADFGGHYMRPDLIRLLVDETPKTNIVDANSTDPKTFPSTLERLGLAKPLPSAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWW6</accession>
    <name>A0A7D5UWW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NT5E</name>
        <name evidence="9" type="ORF">G6M90_00g048450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544960.1">
        <property type="nucleotide sequence ID" value="XM_014689474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWW6"/>
    <dbReference type="GeneID" id="26242301"/>
    <dbReference type="KEGG" id="mbrn:26242301"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029033643" evidence="6">
        <location>
            <begin position="19"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="340"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="580" mass="62921" checksum="FBCBB03921E3665F" modified="2021-02-10" version="1">MKIAATLAVLAIGPVALADDVLYSSRFSKRGLLPNGNYNLSFFHVNDVHAHLDQYTKAGADCTDATKGCFGGYARIKTKVHELQKQNPDHLWLNAGDEFQGTLFYTFYGGEKIAETINDLKFDAMTLGNHEWDGGDENLGKFLKNLTFPIVSCNVKSTVKDLNETIKNYHIFEKHDLAVIGATTETTPNIANVGKGTTFLDPIPEIQKAIYEIRNTTKVKRIVALTHLGYEVDQKLAQQTEGLSLIIGGHSHTLLGNMDKAEGKYPTIVKDKGGNEVFVVTSYRWGEYLGSIEMTFDDNGRALSYHGAPIHMDNTTSLEKNLQKNITAWRGPFEKYAAEVIGSTKNVLDQTACQKGDCLLGQVMADAMLEYRQNQTNGTADKPDFAIINAGGIRATIDEGNITRGQVITSFPFGNAVTQLKYSGADLRKILEGCVSRVSQFNQKKTSSWFQVSGNIVVEYNESRDAGSRLVRATVGGKALDDKTDYNVVTVDFVAGGGDNLLKPATEFVTLESLDQVLVAYIGAHTPLQNALQKRVVSSNGTAGGGAGDGGKASNGESKGASLRAPRLLVGLSFLEALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX25</accession>
    <name>A0A7D5UX25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g064360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986703.1">
        <property type="nucleotide sequence ID" value="XM_066130776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX25"/>
    <dbReference type="GeneID" id="90967860"/>
    <dbReference type="KEGG" id="mbrn:90967860"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="115" mass="11972" checksum="6FD792738170EA75" modified="2021-02-10" version="1">MLFPANRHANLKKSLSLNSSVDDRIGPGDGEQLCAKTGHAAGLDGISIGPRPPPTLRNLGGKLILSRSSSGSGPALLPPVGIERHKVADVVCGNGLRHEQDARPVDKALELSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX45</accession>
    <name>A0A7D5UX45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">med8</name>
        <name evidence="9" type="synonym">MED8</name>
        <name evidence="11" type="ORF">G6M90_00g057350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986796.1">
        <property type="nucleotide sequence ID" value="XM_066130637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX45"/>
    <dbReference type="GeneID" id="26242731"/>
    <dbReference type="KEGG" id="mbrn:26242731"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="194"/>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI69414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="28123" checksum="B4338ED8A284E666" modified="2021-02-10" version="1">MATLALDEDELKSVEHTVARLAQLSSSIQSLKMDILKSNPLPHPSSLQASAQILQRNLQSVLESLNDNAELFTRMVIHPSTNYPGRTQENILTQLLRKKLEPDVEELVAEGRETARLATPEGVAELQAIWDELREWTQGRIAAYVRDEAGDVYTREEREAGVDSVRTGLRRGLDESDEDEDEADEDEDEDEDGEGGGNMVPRGPEPETLLWFGARGDFELPRNVEFERKMGVKRGLEGVNIPPERMDGVASS</sequence>
</entry>
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    <accession>A0A7D5UXJ4</accession>
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        <name evidence="3" type="ORF">G6M90_00g061000</name>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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    </dbReference>
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        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="301"/>
            <end position="321"/>
        </location>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXW1</accession>
    <name>A0A7D5UXW1_9HYPO</name>
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        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="243"/>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="32221" checksum="0DBAF85F365FB4EF" modified="2021-02-10" version="1">MAFTSRSPVRISPWIGLPLSVFMIVVATITFVGAPYGDGSKWPVLTTFRDKRSELNILNYRAQQAPPWLYKGGKGATSILWSILIPLQHSQSIRQRMPTFHRGAGYMVVLLSIELGLAGYYLSSRGMVTTHEKWYHVHSFYGARLPIPFLVWPTFDFSIGVLGVFYFVSLFKLFTAIRAQKVELHRRWAVFHSMTGYAISIERLIAVLVIALGWVLHSMPEHFQTWLQLPLDRDGKMEVELSALAWTLAAAGITVAAWAYIEFAKVRSTESRSGGSRIEAVRKNK</sequence>
</entry>
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    <accession>A0A7D5UYF2</accession>
    <name>A0A7D5UYF2_9HYPO</name>
    <protein>
        <submittedName>
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        <name evidence="3" type="ORF">G6M90_00g065610</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68712.1"/>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI68712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="370" mass="40584" checksum="4CE97D735E37835C" modified="2021-02-10" version="1">MSRQTQPPQARLGTALVLGGCGFLGWHLVARLLSCRDYDHVYVLDRHVQANLNRGATYVQGDITDVSALRALLDEIQPSVIFHAASPIASLPASRHGEFIRTNVQGTKVVIDLATQSASVKALVYTSTVDVYAHPPHENVSEDHPLWAPSDKSNEYNRTKAIGDNLVRAANGAQLRTACLRLGHAYGERQSQGLAEILGSCQGTRPLVQVGNGTNMMEVMSAENCALGHVLAAKALLHEPQPVDDKSRVAGQAFNISDGAPVPFWHHVRVIWGVSRGPEALNNVTVLPAWVMIVAVVLVEWLLWLFTFDTVKPPTELRRTSLEYCIYSHTYTIDKAKKRLGFCPVVDHDAVLARAARLMLDQRAELAKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYF4</accession>
    <name>A0A7D5UYF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NNRE</name>
        <name evidence="12" type="ORF">G6M90_00g061710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986894.1">
        <property type="nucleotide sequence ID" value="XM_066130725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYF4"/>
    <dbReference type="GeneID" id="26244649"/>
    <dbReference type="KEGG" id="mbrn:26244649"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="236" mass="25803" checksum="87AB027A0759D37E" modified="2021-02-10" version="1">MALKTLGAKTAAALDQELMSTCAFSIDQLMELAGLSVSQAVYRVHPLNKGRRVLVACGPGNNGGDGLVAARHLFYYGYQPTIFYPKRSKNELYQRLAKQLEDLEVPFVDDFQSAVDSTDHIVDAVFGFNFSGDIREPFPKVIQALEETKVPVTSVDAPSSWDIESGPPKSGVGSAFMPATLVSLTAPKPLVKFFRGRHFVGGRFVSPSIAKKYDFEVPEYPGVDQIVEVPITSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYM1</accession>
    <name>A0A7D5UYM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dhx29</name>
        <name evidence="15" type="ORF">G6M90_00g070220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987018.1">
        <property type="nucleotide sequence ID" value="XM_066130929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26246527"/>
    <dbReference type="KEGG" id="mbrn:26246527"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000819">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="682"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="929"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI70474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1480" mass="164942" checksum="401397197DE8CAFF" modified="2021-02-10" version="1">MAGNKKKKKPAANPARGFATTSIASKPRPEVSDSEAKPLADGVSGASAPPSKENAPPSAKSTTGDGHGSATAHQTSEDKPLSPEEFERQLEESELQLLVEKHSQKTKRDAQRQRTRLETDRRLLRSQADLVNAPKWLPPDLVEHILDLIKAEMRFAGSSLSSENVGTGKLPSEEDMIVRLWTLRQTLAAAGFPEARVEAVLKHILDIATNVSSSVKDSIWGLDESLEWLARECPAEELPLYEFKGKPISRDTPTDTPNASRPGTPKPLSLSSGKNKANTRGSKSASPNKKLVMTYDLDIEPEDLIPEYVSARAKHLELSRSVRPTDSEDKTQLEIAKLEAKIKKIESDVLFDKFNADLRWKSEKILVERQLAAAKKEAQAAAEELGSKAEQTPEANADDSVNDEADRIAAEILAQEDEDSDAITGLFASLPQNEVDPNTGKTQTVITAADGTKLVLRDFGKWTGVGPRRVLEDSCRSRDPSVRMTYTVVSEATFASRQSVDIWWTKAQELPHVLPDSDVEVAADATHFTFTMKSVAVSDAKQSEAYISTAALFHIFNGNSKDEKVSLRLPPVWKDLWSEMAEAKKDYMDTQDREAVRSLRTMVRQRQDQELEDGVIAFRGRGAARNSPDSTQNGSLDRSRLNTAGVESLQKIWYDKARGEKFQSMLKFRMQLPMWQFRPQVLAAVDDNQVVIVCGETGCGKSTQVPAFLLEHELSQGRHCKIYCTEPRRISAISLARRVSDELGENKGDLGTNRSLVGYSIRLEANTSRETRLVFATTGIVMRMLEGSNDLREVTHLILDEVHERSIDSDFLLIVLKRLLTKRKDLKVVLMSATVDAERFSAYLGGAPILNVPGRTFPVDIRYLEDAVELTGYRPSDSPEEKMVDLDDDVVEGEGNGPKSEISSSLSAYSPQTRSTLTQLDEYRIDFDLILQLMVRIASDESLAFYSKAILVFLPGIAEIRTLNDMLLGDPRFAKDWLVYPLHSSIATEDQESAFLVPPPGVRKIVLATNIAETGITIPDVTCVIDTGKHREMRFDEKKQLSRLIDTFISRANAKQRRGRAGRVQNGLCFHMFTKYRHDCIMSDQQTPEMLRLSLQDLAIRVKICKIGGIEETLSGALDAPSAKNIRRAIDALVDVRALTTAEELTPLGHQLARLPLDVFLGKLILLGTVFKCLDMSITVAAILSSKSPFSAPWGQRAQADNARMAFRRADSDLLTIYNAYLAWKRVCQANSGGGKEFQFCRKNFLSQQTLANIEDLKGQLLVSLADSGFLSLTEEERRTLARLRFAQGRRRQQNFYEVPRRVNINSENDLISSSVIAWSFYPKLLVRDTPGTKGLRNIGNNQNISLHPSSVNRGFLDIKWLSYYHIMQSKTVYHAHETTAVEPFAIALLCGDVRCDMFSGVIVLDGNRGRFALPDWKTMLVLKVLRTRLRELLTRSFKQPGKLPTAQQEKWLEVWQKLFTQDQRDDGKSSGVSVAVAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZT7</accession>
    <name>A0A7D5UZT7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g071150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545943.1">
        <property type="nucleotide sequence ID" value="XM_014690457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZT7"/>
    <dbReference type="GeneID" id="26241976"/>
    <dbReference type="KEGG" id="mbrn:26241976"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="168"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="345" mass="40597" checksum="302AEB1154BCBFBE" modified="2021-02-10" version="1">MDVVLDLYETYIGDHVYARLLPAHPPPYDADLFANTTIFPFGLECEYKPPTKYFTVRPSPAVCQSAWARDNILRQSIDLFLLLWIFGMAVYFLFSTLSYVFIFDKQQQEHPRYLKNQVRLEIQETLWALPGMSLLTLPLVLAEVRGHTKMYDTVAEGPGLWYEVLQFPLFLLFTDFCIYWIHRGLHHPLIYKNIHKKHHKWVVPTPFAAYAFHPADGWGQSLPYHVFTFIFPMNKFSFLVLFVFVVFWTILIHDGEYLADNPVINGAACHTIHHLYFNYNYGQYTTLWDRIGGSHRVPDREMFDRAKKNGKTEWERQNKGVEDMILEVEGQDDRVYSPEELKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZU0</accession>
    <name>A0A7D5UZU0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dao1_1</name>
        <name evidence="8" type="ORF">G6M90_00g079430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539915.1">
        <property type="nucleotide sequence ID" value="XM_014684429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZU0"/>
    <dbReference type="GeneID" id="26247253"/>
    <dbReference type="KEGG" id="mbrn:26247253"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="38545" checksum="01B088FAB22680F0" modified="2021-02-10" version="1">MAASSDSIVIVGAGIIGLDVALVLGKRGLGQCITIVAEHLPGDTSPSYTSPWAGCNFSGISGSDANALRWDKLGYAHLTTLAADYPTESFVSWTQSIEYWDANAPQDKIKSISGYMKDFTIIPQQELPPGVEYGVSCTSVTVNAPKHLTYLYDLLKDHYGVRFLRQKLPSIQAAYASPRTQILFNCTGNAARTLPGVQDAKCFPTRGQVVLARAPTMRKNVMRHGRDYETYIIPRPQSNGNVILGGFMQKGNNDPSTYGHETDSILRRTKGLCPRELRDGPCEVLAVFAGARPSREGGARIERESISVGGSERLLVHNYGAGGTGFQAGYGMALDAVACVDDVLRELEQLVNRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0S3</accession>
    <name>A0A7D5V0S3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">bzz1</name>
        <name evidence="15" type="ORF">G6M90_00g078530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545255.2">
        <property type="nucleotide sequence ID" value="XM_014689769.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0S3"/>
    <dbReference type="GeneID" id="26241288"/>
    <dbReference type="KEGG" id="mbrn:26241288"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000296">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="402"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="581"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="679"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="644"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="318"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI70699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="737" mass="81182" checksum="EC89D2FEA646F8DE" modified="2021-02-10" version="1">MAEVETFGAVLKDGFKPASAWVGHGIAWLEDIQQFYRERSLIEKEYSAKLSALAKKYFEKKNKKSSQLSVGDTPALTPGSLESASLTTWSTQLTTLESRAAEHDKYGNLLVSQVAEPLKYYAGRFEELRKRHIEYADKLAAERDASYGDLRKVKGKYDAVCQEVESRRKKSESHYDKAKAQSAYQQQIYEMNNAKNSYLIAINVTNKHKEKYYHEYVPEVMDSIQDLNEFRTLKLNGLWGVAATLEGTMLRDSSSMMDHLGQEVTRNLPHLDSIMYMRHNVGSFQEPADREFEPSPVWHDDATMVVDETAKIYLRNVLSKSKSQLGELRREVDKKRREVESVKKLKQRVRDGTENKDEVEVARSLFAMQEDLHAADRQRLTAEVETGTITAVVGDVTLGAKNHNFKGQTFKMPTNCDLCGERIWGLSAKGFDCRDCGYTCHSKCEMKVPADCPGEQNKDERKKLKAERQEAANRLVARDPAAPSHVADLPDLTRSNTMNSLSSHSAKRSVSGQITPAELDAGEPPIAARPSISPNPTGGSVISTTTSATAATGTRKRMAAPPPAAYVSELPGSGVNGNGHKEERKGKMLYAFEASGDGELSVAEGRDVTLLEADDGSGWVKVRAGYKEGIVPTSYVELAAPSVPTATRPESTYSTSTTSSTGPGGKKKGPAVAPRRGAKKLKYVEALYEYAAQSADEHSMVEGERFVLVKEDPGDGWVEVEKAGVTGSVPASYVHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V109</accession>
    <name>A0A7D5V109_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g072400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V109"/>
    <dbReference type="GeneID" id="26241856"/>
    <dbReference type="KEGG" id="mbrn:26241856"/>
    <dbReference type="OrthoDB" id="5401106at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="985" mass="109100" checksum="9AC6C54FA7F8D30D" modified="2021-02-10" version="1">MATQPDCYMGSIVAFEGKADIVSTQLRLLPTSPQVLILPSVDSYAKPRDQDEDQCFDAPSFIRRVHDAFLARAEAAQNFLNGATANHKRLVFINGGTSGAQALCIKEIMKHETHGDRCQAESIFEEITKDGLAGLEKQISNMGREERYAFGHSTAANDKEELEEDPITRAMRAADALDRQTANLQPCNTFPLGRPSRPRSWSLPLYGFSDELEDSTPFYVFGLARPDEDVAPDESTENFSEPPTPSLVISRPGQSSVDKPRLGPSFSTIFYPASCIGEAYESITPDCQPEAAAVSPTSEAFSLRSSDNIVYGEAAVFDMRNPSSRNSICRVKSLGRIYNASPKLRDPCIPSESWLAEPDTPRDWQHRHSVISASDAQDRRLSLISLVDKPRTVMVKSRRSIGKMEPVPAEKRRERAPKAPENPRPNYVDRGTDTQNDKPRDVSFQPIFPPMEDLVVYFKDESSDVMLESAVNTLRNRRYPLLSHSPTTSDVVNTGASAPSTPVYQPFQEREHVESGMSAHEHGMASPDAEDYDPFAYTQTMWRPEKSVKQAASVSIVRPPTPAQTPPPTTLKDIEHKVHEFQVTSGHTAVSIQNSLRSILGEYFPPDTKGCHQFQFSLLPEFDELWKPIFRGGEPGTSQRNDATGTNILAIGSQTGVKKEYSLEVIGRLEKVGRKSCEIVKTGRVDFRYLLANAMQAFTAQRLANQTSDNPFTNSFLLATLIVPHLETYLALHTDVRHLLLIYPPEHLATVLALQRLVGVDVMKVAQIVDAESKEDSPFTNIRGASINNNKPEGKPTRSFSPRSSSEIDISKANYLLTSTASEKDIATFVSTVWNIKIEPPLAPNSEQSTDKPSKKKRPPPLSLRKYPLLSLPKLASESSVSPTSIALPPAPPVPLEPASPTASLRAPSLAETFKALKSAKNKLSQGRLWPKNDQQVEVESLADYDFGGDSDDDMYERRLMPVFMQKHPVRKPNSRKALKFLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1Z1</accession>
    <name>A0A7D5V1Z1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase fsa4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fsa4</name>
        <name evidence="6" type="ORF">G6M90_00g086060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541165.1">
        <property type="nucleotide sequence ID" value="XM_014685679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1Z1"/>
    <dbReference type="GeneID" id="26246154"/>
    <dbReference type="KEGG" id="mbrn:26246154"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="70"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="185"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="45942" checksum="1B4C5A5262EB20DA" modified="2021-02-10" version="1">MAQQSGQSAMFLADRMEAVARQLLSSADTLRVNPTAKQDHAGIIESTYSLLAKLKDPLDNVMDQMVCLSKFVAMRLFIKWGLFDKIPTNGTISYQELASGIGAKTGLIARFGSALVANGVLEETEKGTVAHTAQSKVLLSGNPINALICLGFDAHLKTLARLPDYFDKFGLGEPIGRENTPIAFTVGNASLTIWEHMNRSPEMKRTFMLAMQAMATRHGIIGDYSFEWVVDKAAEWPDRPLVVDVGGSKGHALEAIVEATGLPMERCVLEDLEPVLEMVRSQADGPIKQARLVALDFHTEQPVKEAFVYYIRRCLHDYGDADCIKILNQISSAMAPDSRILIVENVLGDLPSPVSIGNDILMMLLGGKERTLEEFKSIMGEAGLEVEKLWRFKGTDYAIIEGRKVTGKEVKQAGVRSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V278</accession>
    <name>A0A7D5V278_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HEXB</name>
        <name evidence="13" type="ORF">G6M90_00g082340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543463.1">
        <property type="nucleotide sequence ID" value="XM_014687977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V278"/>
    <dbReference type="GeneID" id="26243640"/>
    <dbReference type="KEGG" id="mbrn:26243640"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028882632" description="Beta-hexosaminidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="11">
        <location>
            <begin position="190"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="578" mass="63020" checksum="C0D4F4F76EC7C977" modified="2021-02-10" version="1">MLNNAIIAVAALAALRPVDAIWPVPQQISTGQDVLFVDKSIQVTYNGEPVSHDGAGETKESPSSSSQVVHGAVARSLTAIFEHGLVPWMLNPPGSDFEPALDGGAGKVTSLTITQTGEDNATVFKPLAGQVDESYSLHLEANGEASIEAVTSTGLVRGLESFTQLFFKHSSGDAFYTKQAPVSIQDAPRFPHRGLVLDLSRHWFAVDDIKRTIDGLAMNKMNVIHLHITNTQSWPLEVPALPKLAEKGRYAPGLTYSPQAIQEIQEYGVARGVQVLLEIDMPGHVGIDKAYPGLSVAYNEKPYDKYCAQPPCGALKLNNTDVENFVSTLFDDLLPRLSPYSAYFHTGGDEYKATNSLLDPDLQTDNMTLLQPLLQRFLDHAHNNIRGHGLVPIVWEEMVEEWSADVGNDTVVQAWLGSASVAKLAAAGHKVIDSTFDVYYLDCGRGQWLDFKDGPSLDAAYPFADYCSPTKNWRLIYSHDPVENMTAEAAANVIGGEVAVWTEMIDPVSLDTLAWPRAAAAGEAWWSGRKDGEGNLRSVFTARPRLEEMRERMLARGVRGAVISQLFCGQSPLEDCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2J8</accession>
    <name>A0A7D5V2J8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homocitrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LYS1</name>
        <name evidence="3" type="ORF">G6M90_00g099070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546441.1">
        <property type="nucleotide sequence ID" value="XM_014690955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2J8"/>
    <dbReference type="GeneID" id="26240864"/>
    <dbReference type="KEGG" id="mbrn:26240864"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-isopropylmalate synthase/homocitrate synthase post-catalytic" evidence="2">
        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="174" mass="19353" checksum="7F69ED5760D25358" modified="2021-02-10" version="1">MARMMVGSRDYVMSRYKLHKIKEIEGMVADAVQIVSEYLGNGQTTLRALAPALVSVPTTVPDGRLAEWRRHNIPFNNPITGTLYMPLHLTLSKTNLSVSPLKEVLMFLAMLGFCAFSHKAGIHAKAILANPSTYEILSPEDYGLSRYVHFASRLTGWNAIKSRVEQLGLSMSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3L8</accession>
    <name>A0A7D5V3L8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monacolin J acid methylbutanoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lovD_1</name>
        <name evidence="4" type="ORF">G6M90_00g104950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987729.1">
        <property type="nucleotide sequence ID" value="XM_066131661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3L8"/>
    <dbReference type="GeneID" id="26245735"/>
    <dbReference type="KEGG" id="mbrn:26245735"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="43"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="396" mass="42077" checksum="60E965AC637E34F5" modified="2021-02-10" version="1">MDHTQPFESAISGGILPCVALLARRLDNSDVLSTYLGPKSIAAADPDPIDANTIFTLASITKLATTVAALQLVERGLIQLDDDVAELLPVLCRQKIISGFDDQGQPVLQDRKSPITLRHLLTHSSGAGYTFLDAGEKLRQYHRFHGTPPNHGPTVESRFGVPLLYQPGEGWAYGAGIDWAGRLVEQLSGQSLEAYFTEHIWKPLGASGTFTFFPGAQGRAGMASRGPGGPDKLAPVPGGLGLNAGVEACFGGQGGHGRADDVLKLLHSLLANDGRLLRPQTADAMFRGQLSPASKAALKQSLEGSAWAVGDYYPGEEYDWGLGGLLIEKAGDGAPYARGANTLTWSGAPNLFWFIDRANGLCGLFVTQLLPPGDAGATDAIREFQKVAYQKNKTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V417</accession>
    <name>A0A7D5V417_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g111250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543737.1">
        <property type="nucleotide sequence ID" value="XM_014688251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V417"/>
    <dbReference type="GeneID" id="26243124"/>
    <dbReference type="KEGG" id="mbrn:26243124"/>
    <dbReference type="OrthoDB" id="5089079at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028937499" evidence="1">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="163" mass="16219" checksum="0BC8D68C79F0FB48" modified="2021-02-10" version="1">MPSKLILTALVAITSAQVIINGKTMGGGSSSGVTCPGVLHATANSQGSNTYCCVGGTLNLSNCPGWPVCTGPTRFDPKSTTLSCAATVPLTASDYNARVSSASDSYYNGIASPTKPAQTSASPTGRGGGVNFSGNVTVSGADMMRPAWIPVIGGVVALVAVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V496</accession>
    <name>A0A7D5V496_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PNO1</name>
        <name evidence="11" type="ORF">G6M90_00g109770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543879.1">
        <property type="nucleotide sequence ID" value="XM_014688393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V496"/>
    <dbReference type="GeneID" id="26243266"/>
    <dbReference type="KEGG" id="mbrn:26243266"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="168"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="258" mass="28435" checksum="B756DEA4FBC44273" modified="2021-02-10" version="1">MPAPTALKKAEETPLQAVAASSQTQDNGGGFLLGEPDAMPVDADAAPTADEQEDDSMAIDEEGRPRFAPSRDIDPVTRVETRKIPVPPHRMTPLKQAWPSIYPPLVEHLKLQCRMNIKRKTVELRTSQHTTDSGALQKGEDFVKAFTLGFDVDDAVALLRLDDLYIETFEIKDVRIMHGDSQARAIGRIAGKDGKTKFAIENASRTRIVLADSKIHILGGFKNIHMARESVVSLILGKPPGKVYGNLRTVAARMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4M4</accession>
    <name>A0A7D5V4M4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">vps54</name>
        <name evidence="12" type="ORF">G6M90_00g106910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539906.2">
        <property type="nucleotide sequence ID" value="XM_014684420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4M4"/>
    <dbReference type="GeneID" id="26247345"/>
    <dbReference type="KEGG" id="mbrn:26247345"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="11">
        <location>
            <begin position="269"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="10">
        <location>
            <begin position="807"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122247" checksum="1DA81767A6306891" modified="2021-02-10" version="1">MIASGIDIVLQEMLALAKTYDPTRERPLLEVTRILQLLFPGKKTFGGWRVEGLLAVLGVNSIEDIDIACTIEYPISTLLQPPIVRTGLLSHTSAPTLSAHKPPTTRDIPPVALTNITHVDVAEFKPYLTQVGALYEQLQRLKERENESADTLDSGSGKTSQFAAVFDDGHLQQGKRCLSSPSPTEMSVAIPRFSSGSARRATQSAPPLSTVPRVYFDADFHLENPRTFDVVSERSEVVRPPPGLLNEKASKGNATAPRKALATNAILQEKLSWYMDTIEMYLIASISAASTAFFTALGSLQELQSEAADSVERIKALRKELEALDKEIVISGLNIIQKRQRREHLQQLHDAVQQLQHIVDSVVACESLVDNGEVEKALKCVDSLSKLIAGEPDASQAPLHIDGQDIQLRDLRAVIALQGVNDDLITLRIRIGKAYAARFLSLLMGDLGRHTDAVSTQEVLMRRTSASVRSRGGHTQEASVVPSYMSSTDGLRSELLEVLTSLHRAKHLTSATSAYREAVLKEIRNLVRRPLPTSNDDDNESILSSSTMARGQFAPQEKSSILARNLRALQPEEAEELLIKIYISVTETLRRSTTQVKLLLDVASSLGDDTGPSGLRCTEMDSPPITPAAWRPSVAALEAQEIHKAIDLLSLLGEAVDVAQNKTVKLLRVRSEQSTHLSLIRFLRYFALNLYFTNECESISGQSGTALKTIINGQIQDFIQQHGDVEKQKLVQGMDSDQWEAKDFSEKHTAELDRILSCSTKDPAEWSDGIKPWILYSDDDPGFNCADDPQLNSDDKAKTRNASIHEEIFVLPSSAIICMNGVARFLQLIVGIPSMTSDIVASLVSYLQLFNSRCTQLILGAGARRSAGLKNITSKHLVLASQALTFVATLISYIREFVRRHAGTGAAASSLVEFDKVKRLYQEHQNSIYDKIVEIMTRLAASHVKTIKLIDWDNEQKNVHSYMATLTKDTTSLHRILTKSLPEATVGMIMTPVFISYRNQFGKAFQEVDPMTELGRESMLHDIEFFESKLGKLDGFGDTAEYLTTIIKSKQVTTGRPANLADGQLEKKDTENTANSAETRDNTEDKDEEPDKADDGKIAADAVSDPEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Q7</accession>
    <name>A0A7D5V4Q7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cbk1</name>
        <name evidence="15" type="ORF">G6M90_00g098310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987682.1">
        <property type="nucleotide sequence ID" value="XM_066131540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Q7"/>
    <dbReference type="GeneID" id="26240936"/>
    <dbReference type="KEGG" id="mbrn:26240936"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="174"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="491"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI73511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="656" mass="75957" checksum="B4E286024ACA14A1" modified="2021-02-10" version="1">MPSSPSLPLGDAVSSISSLGTDKSSVVGNNSTRKTSVDSRVSQSTSNKASPKRRRSRRHPWSRSSPDAGTLQTIDEGLYQPQPTILTVEKAAGAKVYLETYFNNLLNKPNARAARQQYLESQLYYSPHLDLDEKDVIRRSFYYQETCHSRETRVMTIKSLLSLDRQDLSYAENYDCLKVLGRGSFGVVKLVREKASEAHAFPRQVYAMKIIRKSEMLRSCQEGHLRAERDFLVASEGSNWIVPLVASFDDLTSLYLVMEYMPGGDFLGLLIRENILPESVARFYIAEMILAVEEAHRLKFIHRDIKPDNFLISASGHLKISDFGLAFDGHWSHDLSYYNCQRYSLLGRLGIRVDGDAEDRKKSANISSQIPWLQAMKEILDRHERKSSIGIILYECLYGHTPFFADDGRKQTKSNILDHKKIFSFPHRPLISDKCKDLVYRLIQDKELRLCSRRYQMKDRCQVDNRRYTDIFGRHVFPDDAEDIKSHRWFKNFPWDRVHAINPPFVPHITSLDDTHYFDESDPFTEPMASSENETVDPTPDHIRWVLRECRPVVQNLAIELIATPYDSTRLRSADRRIDRTFNISPEERKTLKTFIRMYGRKERKRPRDILLRDQSTKTLALDVRKKTAFMGYGWRRMRPGGYITPNLGKYEMAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5N0</accession>
    <name>A0A7D5V5N0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclochlorotine biosynthesis protein O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cctO_5</name>
        <name evidence="5" type="ORF">G6M90_00g111010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543760.1">
        <property type="nucleotide sequence ID" value="XM_014688274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5N0"/>
    <dbReference type="GeneID" id="26243147"/>
    <dbReference type="KEGG" id="mbrn:26243147"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="31372" checksum="805776CDA65B6C16" modified="2021-02-10" version="1">MDMASIRYERLEATDKFDPADDDSNNNIINTATEDTSSPSRRRPIWTRRQATLALLGNLVLLLTSICLLSVAARRRPSPSHLECAQKVSPYSPMWEAVEFWEGNFANEFNSSTKYRGPPTLERERAWNDLWHYHLIRVDAAGVAALNQTHAGRHAQVKGSDPAHPQFGATIEVFHQLHCLNVLRQYSWPLDRFDPSWGEDLYPSMLQDAATGRTHVDHCIEALRLSLMCTGDITPVLFLHDEASPLGVRADFNIHHKCRAFGPLVDYVQRNGVELET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5P9</accession>
    <name>A0A7D5V5P9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g109580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987872.1">
        <property type="nucleotide sequence ID" value="XM_066131784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5P9"/>
    <dbReference type="GeneID" id="26243285"/>
    <dbReference type="KEGG" id="mbrn:26243285"/>
    <dbReference type="OrthoDB" id="5396937at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="149"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="568" mass="66003" checksum="2299A1E69F52013B" modified="2021-02-10" version="1">MPEQPPRAVAMDPPHITEFASERYFEKLSQLNASQQNHRHHHHHHHHHDHHHQQQQQQQQQQQQLPDASETLSTPSAAASSTFILPLRDTKTVELEPSKQTEQKKDRSRFFGIRQKVSLLHSKPHGVDIETHLPIRASTESTRKSAPFDLLFLALPNELQVEILSLLPLTDILSLRLASKTWHSLITANEAPIVRYHLDTHIPAYTLRLYPITDQSEVNFHYLCSLWHRLHVAAKLAHLMCEWITKEIFLRQSEAQQLAFTPQRERMRRRLIPLLFTVFHFFETYRKLHLQHIVEHDGHGLRKEPYTLNPIESEIMNMYDDQTLLRVHEVFPLIISSFCRRLRPPTYVGRVERSLRGYLRDRPSDEIHSAILCIGGLRQVERLWEIKGYNNRRAAVDVWYNSLTRDYKELVLEPPPVKSRLGLKGFGRKKSTSGDRPAHRSSFSETFGKTRSHTGSIDASFMDSVIDYNWVFHTSLAADAPMSALSHDDVQKLLDDTPVLQQIWLTTAEALILDRRIVPRTQDIKRNQQVMLDLIREDGLDEEDEWWYGRNNPDSIRPSASAGDDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5Y5</accession>
    <name>A0A7D5V5Y5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-methylsalicylic acid decarboxylase atA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atA_1</name>
        <name evidence="8" type="ORF">G6M90_00g094300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987689.1">
        <property type="nucleotide sequence ID" value="XM_066131477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5Y5"/>
    <dbReference type="GeneID" id="26246407"/>
    <dbReference type="KEGG" id="mbrn:26246407"/>
    <dbReference type="OrthoDB" id="4936350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="422" mass="45533" checksum="20E09E8728F78393" modified="2021-02-10" version="1">MSNLSVHRTRIAIIGGGLAGTVLANALLPRAHLDVHIFEADACFSERGAAIGLSSTAQSALKHVIPSADELLAKAGAVPMNSTRTMIGSGVAAASLVLDFARTSQGKVVHRGSLLRELLSGLPSSMLHTGKKLMDMNSSDDGIELTFEDGYMARFDAVVGADGIFSRVREHVTRDPGGVYAASPAGFWDCRNLVTVEKARAMLGQDLFRVHRQYGWIGNGAFIMHDVLDHGHKIQCVISGVEAKQAKHRATPLSRHDLNLVLKDWLDGPIAKGMIELVLDQDNPQRFSQWEHKSTPTYSNGRTCIMGDAAHATTPWQGYGLGLAIEDAVILSTLLAESSCRGINAALQAYDAVRRPRCQMLIDSSRGTGRILCGQDGYAGLDPGRLKQVLAPRWDFIHGLDIEAHKQDALGALKELQASTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V631</accession>
    <name>A0A7D5V631_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g109430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987966.1">
        <property type="nucleotide sequence ID" value="XM_066131779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V631"/>
    <dbReference type="GeneID" id="26243299"/>
    <dbReference type="KEGG" id="mbrn:26243299"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="58"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="376" mass="40837" checksum="3B3BE0A472CDE62A" modified="2021-02-10" version="1">MSSSLSPDQFGSAQSHSSPDGTATSQDRSPLNLGFLKSLTEKRTTRDGNPAKRRGPKPDSKPALTRRQELNRQAQRTHRERKELYIKALEDEVLRLKELYSNVSQSKEKLLAENRHLKTIMAQHGIQFPRSADRDDGGSPGAAGASPGNSGAPGSYASFSPGSQSGASTGHSTNFQPMTGQQMRGVVQQSANKGVDFEQAGIDFVLTYDNPASSRAYLSPPPQLEKPCMQHLPFLTDRSEGGEPCGHALMATCPPAPFGKLTPKTPFGNSHTHDHGDGSNPAQGTWEISKADLSTLLDLSQHLDLDGEITPVMAWGMILSHPRFADFQPEDFARIAAELGRKVRCYGFGAVMEEFELRDAFESVLPSGLEPEIMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKM6</accession>
    <name>A0A7D5YKM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein sti1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sti1</name>
        <name evidence="9" type="ORF">G6M90_00g025270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548056.1">
        <property type="nucleotide sequence ID" value="XM_014692570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKM6"/>
    <dbReference type="GeneID" id="26237500"/>
    <dbReference type="KEGG" id="mbrn:26237500"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="525"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="577" mass="64280" checksum="CEAE695B4C87F6BF" modified="2021-02-10" version="1">MASADELKALGNKAIAEKNFDDAVDKFTQAIALQPENHILYSNRSAAYASQKDWDNALADAEKTTQIKPDWAKGWGRKGAALHGKGDLLGANDAYSEGLKLDANNAQLKSGLASVEKAMQNEAGGAGGFGADPTGGLGQMFKDPNLIQKLAKNPKTSGFLADPSFMAKLQQMQQNPGNPQDLFTDPRMIQVLGVLMGVDMDVRDTDPRGDTNMPDAPEPKKPEPAKAPEPEPEPEELDEEALEKKKKKEEADKEKFLGTENYKKRKFDEAIEHYSKAWDIFQDITYLNNLGAAYFEKGDYDKCIETCTKAVEEGRAVYAEYKLIAKSYARIGSAYEKKGDMAQAVENYSKSLTEHRTPDVLNKLRAAEKAKVEAEKNAYIDPVKAEEAREEGNKKFKENDFPGAVQAYSEMIKRAPDDARGYSNRAAAFVKLFEFPSAVDDCNMAIKKDPKFIRAYIRKAQAFFGMRKYSDCVDACTDATQVDQEFHNNANAREIEQQQQKALNAMYSARDNETEEQTRERLMKDPDIMSIMQDPVMQSILQQAQSNPMALQEHMKNPGVRSKIQKLMAAGVIRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNV9</accession>
    <name>A0A7D5YNV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g032500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986284.1">
        <property type="nucleotide sequence ID" value="XM_066130111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNV9"/>
    <dbReference type="GeneID" id="90967598"/>
    <dbReference type="KEGG" id="mbrn:90967598"/>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="49" mass="5810" checksum="2F46A83D841C8250" modified="2021-02-10" version="1">METVEHIGKVLSFIFKKIMELGKKLVRWLGYLFEWGNIKDTRDSILNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRK6</accession>
    <name>A0A7D5YRK6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g017440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548786.1">
        <property type="nucleotide sequence ID" value="XM_014693300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRK6"/>
    <dbReference type="GeneID" id="26238230"/>
    <dbReference type="KEGG" id="mbrn:26238230"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="671"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="714" mass="80114" checksum="69D92619476FC3A6" modified="2021-02-10" version="1">METFAHLNGHRQHASAALTPNHDQNHLSSSNTRDDIAPDPLVESPSSPSPDLPPAQQPSRDNCDRRRPQEEDNTRLKKMASELVVKTVSPFLKEHIPGLYAPVGKDNTKTGAKSPATWTRIKDPNTKFCYRHRPDSKCRRAADETKMGFIQSELNSLPTADQEAITHVWSLFSAAPSKQRELMLQGIITQCCFPQLSTVSREVQEQLKIDFLAALPTELSYKILSHLDTVSLCKAAQVSRRWRSLADDDVVWHRMCEQHIDRKCTKCGWGLPLLEKKKLMAWSRHQTAHHRHDQAERAGPSVETNGHRADSPESNKRSNPSADDGPSKRPRLSGPSNSRSHLDNERKFRPWKDVYRDRYKVGFNWKTGRCTIKTFKGHENGVTCLQFDHNILATGSYDTTIKIWNIETGEVIRTLRGHTSTVRCLQFDDSKLISGSFDKTIKIWNWQTGECLSTLQCHTEGVLSVHFDGCTLASGSIDKTVKIFSFGNKETFSLRGHTDWVNHVRIDSPSRTVFSASDDMTVKLWDLDSKQCIKTFRGHVGQVQQVLLMPQDFEPDEIPSDDKADTISVHSNRSATPTPIPEQPDDSRASFGCGFTHDTTRPLPPRYMLTGGLDNTVRLWDIVTGKCIRSMFGHVEGIWGLVGDTLRVVTGANDSMTKIWEPRSGKCERSFTGHAGPVTCVGLSDSRMASGSEDGEVRLYSFEGETLEERGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRS6</accession>
    <name>A0A7D5YRS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g031350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543074.1">
        <property type="nucleotide sequence ID" value="XM_014687588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRS6"/>
    <dbReference type="GeneID" id="26243875"/>
    <dbReference type="KEGG" id="mbrn:26243875"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="175" mass="19152" checksum="91CF0631D270E323" modified="2021-02-10" version="1">MSSVFTKDNTPDLGRAILRVSPLVLSSASLMFSWSQDISFRAFLHHSLRNDPAHPSGNILPRYLPAFMKPGLWGIGLTYLPATALCIVNGLSNQTSEVRGFYLAGAVFSIAHFCWGPSMFAILRRIGDPQTAGVPNEDALETWLPRHHSRTLLVNVPAFLCIFAATLATITEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRT1</accession>
    <name>A0A7D5YRT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547110.1">
        <property type="nucleotide sequence ID" value="XM_014691624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRT1"/>
    <dbReference type="GeneID" id="26239673"/>
    <dbReference type="KEGG" id="mbrn:26239673"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
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        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
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        <location>
            <begin position="716"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="913" mass="99958" checksum="F3641F305AD5DF7E" modified="2021-02-10" version="1">MAQTPVVPPRPSRSSGKEAPTHLMPQVPPRPVNKRLDRSISPGRDRFAQSPLTAGIPSEPVDNRLSKHYVQKEQAEDPIERASSVGMPSVGEEGMEYSAVAAELEEEERRPSSPEQTRSVAEDLQLHAPKPSLPAQSAKQQVMAVTRTDSDRAASFGIGQPSNGEDRAVSRASTRKRPESSISAYSDLGNHTDDDRGIPEIGQRVPMNKHLGDVQAPSPGPEISKKHHSRKLSGRALPPGSYGLHGHGVVPQDKLEKAYFQKHPEALEREQHTPRHERHNDFAMSSSDLNKLVRDTANHHARAASVELRGTPTDDVAFEASEKYASRISSSRPASTVFADGNAPISSQHAANEEDNAIHVDDSKNPEFYSYGEGKVDEESEEYTAPILASDELNKDPSPHVHQPAIRPHLERRGSSFDGEDLPSRPPSRPRVQRYQSHQQEVKHTPLEDVEEYDPLFPEDGKEEKSGEKEEPVDENCDRRHFPSKDIWEDAPNSVHYTAEVSTPDVAEPERRRSSAQPGDRPITPAQAFALYQEELAEKEANKRGNTFLPLQDSKPSWVSHQPHLQTEVRPSSGSSRRFPSRDIWEDAPDSHIHQAEVSASPVDASPVEKTKPDIPTKAVKEAELSPERPAVPDRPKGRQNSGDDAVKARPPVSDKPKPSIPPRPAKSSPGESKDGISSKTKPPVPNRPAGGKIAALQAGFMSDLNKRLQLGPQGVKKEEPPKEEEAVDDKEKIPLSDARKGRARGPQRRAPAKSPAAATSSEAKAAAPVLSFSITQTVWSVDPEHGGFSFSNKDDSPAKEDTKPEELSTALKPARMSAVEPEEAKGAPEQLESAKEVADSEPISKTEKLKLLDDESAGGPDIEENIEKHTKDERKKDITLASNTAGEGILEATIKNDHDEVEPIEVQEDVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRT2</accession>
    <name>A0A7D5YRT2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FAXDC2_0</name>
        <name evidence="7" type="ORF">G6M90_00g040500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547398.1">
        <property type="nucleotide sequence ID" value="XM_014691912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRT2"/>
    <dbReference type="GeneID" id="26239961"/>
    <dbReference type="KEGG" id="mbrn:26239961"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="124"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28944" checksum="9B0C6302C79BC054" modified="2021-02-10" version="1">MTVALNVAQLWAQLVATHDPYTIDIVGNLVVQFIFWWLPCLFFVSLDALAPAFSARHKIQPAPRQPTAREIRNAALVSLRNQAMVLAAQAALAWYGSSGGHGRGPAVRVEPGLPSAAELARDAALCMAGREVLFYYAHRLFHVRWLYQRVHKVHHRFTAPVAFASQYAHPAEHLLANVLPVALPPMLLRVHVVTMWVFVACQLVETATVHSGYDFLRGLARKHDRHHERFNVYFGGIGVLDWWHGTDERGGPKAGRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT22</accession>
    <name>A0A7D5YT22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g031080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT22"/>
    <dbReference type="GeneID" id="90967584"/>
    <dbReference type="KEGG" id="mbrn:90967584"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028826264" evidence="1">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="197" mass="21931" checksum="9C8E880F3BDC6B12" modified="2021-02-10" version="1">MKYFILLLAACGSLAAALKYPSVGDIILHARVCEKAENIDVKQCKRAFVKYVRQFVADHQHRSVSDEIFWNTMKQWSLLRTPVNYALYCDDGDKKFKCEPSELNTNKLDCQSVSTRAGQNCPDEDCLPFSNLTSFCDEKGGCETCRDAGTVKNSRSIAYKQEPANSATLKKRFGGALLNFSCTLKQGDGSGNMTRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUK9</accession>
    <name>A0A7D5YUK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548671.1">
        <property type="nucleotide sequence ID" value="XM_014693185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUK9"/>
    <dbReference type="GeneID" id="26238115"/>
    <dbReference type="KEGG" id="mbrn:26238115"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="75133" checksum="2C4350B07A618569" modified="2021-02-10" version="1">MSEDHPAASSFGEPNAQPPTPKQTPTSAVFPSPVFETPKHYQGSFVEAGGLTPRFAEEYSVFNATPGNLRGTQGPFPDLIPIAPVSSSASHKRLLSAEGLAIEIAAHTNHFSPNPSATLPPVAPAHRLPSSPNPPTTDTASSTAGFKSPLNPKLSETPTSSPKKARRCTTAEEPTQVISPPPTARKGERWLAPGLNMQNDQSFGRSDFHDLSQQEIAALMSSATDMFGYPMSAPAATHSNFWDPTMSMNMDLDFTAAGTNMFQPPTPSSHRHTGSFDWNSEIQLFQDPNAPPSSNQENVQPTKEERPLAPKPTASDIVCTGAHDSTLLASFAPVLEDPFNMISAGDAVDPGLLFSRPQSAPIAASFGTTVQSGTAEAAIQSRKTPVGEGRRSGSVRDRKNSTKDPERATASSPVKSLGRPGLGRSMSENRGRKTVRRGSLPMLAPAARTAAPDPGLRGSKSTGRLPGRISPLKTQQRLSSLASIPEMSPQARQHRSVRLSINAHGRATVETLLGRGGTAMTRSQSSQDLSTHRSWSSAEDDSDTDDEPIIIPSRNNSFKASFALPDPRKPVGSMFSSRRSASDRSNSNSANEGESEAETVINEKPGKYGDATSELRKVVEDRQKRSLRLGSATSSQRSLNTIIRNFPGGIISPTSLTESSYGPDSYNVRCVCNSSKADETDGFLVQWYVSPSPAGFTFQSGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUV2</accession>
    <name>A0A7D5YUV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">msy2</name>
        <name evidence="11" type="ORF">G6M90_00g051240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539810.1">
        <property type="nucleotide sequence ID" value="XM_014684324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUV2"/>
    <dbReference type="GeneID" id="26247365"/>
    <dbReference type="KEGG" id="mbrn:26247365"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="392"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="735"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="854" mass="94516" checksum="98B3408366EA831D" modified="2021-02-10" version="1">MTDNGIPLTTVRSNASSTGARKANTGNTTSYDSSPENTFEKNESEMHHRHAGRRRKQGDDKLSRRGTAGSDEVSVNALGRLYAKIVGFSVVTRYMVYIVPVGLILAVPVLIFRFTDFGDGTFVGGRDGPTLFYLFLWILIAWCALWVAKIAAWVLPKVFMFFCGIVSMGVRKYATVLKNLSIPLSLFFWALAAWLSFKGLFNDALSKNVVWVRNMERVLGALFVSLVVFLVEKALVQLIGVSYHQRSFANRIKASKREIHLLGLLYDASRTLFPMYCEEFAEEDYIINDSIEMMLRGKKGKMMGGNGAATPMKIIGDVGRFGDKVTSVVGHVAKEITGKQVFNPNSAHSIVLEALEKKLPSEALGRRIWMSFVLEGKDALYLEDFEEVLGPAYKQDAEEAFNMIDSDSNGDISLDEMVRKTVEMGTERKAIGEGMKDIGQALRVFDKVLMFVVLLITILIFLVFFQSSVVTNLATAGTALLSLSFVFAVTTQEFLGSCIFLFVKHPYDVGDRVEVGGTQMLVERISLLYTVFTKTAQNQSTQVPNIVLNNLWIDNVSRSKAMTESFQVDVSYDTSFEDIELLRAEMEKFVRHPDNSRDFKPDFTIGVGGVGELDKLTLEISIQHKSNWHNGVVRATRRSKFMCALALALKKVPIYGPGGGAEALGGPTNPTYSVAVTDEWASKSRDAVAKDKDAGRMVPVQTGQTDAEHRSAEEHAAAELNARSLAVETSGNWGEFRDDRSQRSPSEDPRRSRDIESVRNELLKKESQRGRRKAGEGLQTLSPTETHGGYSAHSPRAGPFDEEAQTGIPQRFYSVSRSHEPTVPEEEEGLHPTGPYSVGGLSHKPSRGPSSGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV18</accession>
    <name>A0A7D5YV18_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">metXA</name>
        <name evidence="3" type="ORF">G6M90_00g050610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI66604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545165.1">
        <property type="nucleotide sequence ID" value="XM_014689679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV18"/>
    <dbReference type="GeneID" id="26242506"/>
    <dbReference type="KEGG" id="mbrn:26242506"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="40149" checksum="41523D266978A3D9" modified="2021-02-10" version="1">MADYQTYQLGDFKLVSGETIPNAFIAYKTIGDPSLPAIIYPSWFSGAIADNEWLIGEDKTLNPRKYFIIIPAMFGNGQSSSPSNTPRRPFPAVTLRDNVTAQHILVTQHLGVRHARCILGWSMGACQTYQWVTQFPDFADCAVPFCGAARTSLHNQVFLEGVKSALLAAKGASSAGSAQGEATPADEYRAWTAPERTAGLKALGRVYAGWGFSQAFYRQRVYETALGYKSLEDFMLNFWEKWALSKDPENMLLMLAGWQAGDCSDQEPYKKDFELAMRSIKTRMLVLPGREDLYFPPEDSEYEVRCMSEGVGKCVPFPSIWGHWAGGPGLNPEDLKWLDNKLRVFLEDEATLMSEVSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVG9</accession>
    <name>A0A7D5YVG9_9HYPO</name>
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        <submittedName>
            <fullName evidence="4">O-acetyltransferase PaAT-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PaAT-1_2</name>
        <name evidence="4" type="ORF">G6M90_00g075470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26241584"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="104"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="526" mass="60667" checksum="5A90BD8A661584C3" modified="2021-02-10" version="1">MNPRDDLTPTSSQEENLGLLDDKISTDSDSEGGSVTDAQSWFGVRVQYPDYSKHLWTVADRWSHLRSAPWRVLSIRAVVFLMPSFLQGRHAREQLCPPKLAPTAYLDGMRGLAALFVFFCHYSYQAFTIAKSWGTGTDNYHFLKLPFLRLWYQGPVAVCVFFVVSGYALSYRPIKLIRSGALSDFATTMSSLTFRRALRLYLPTAVSTFMIICLLRIGAYEWTRQFASDRMYMKNIVEPHPVRMESQYAQFRDWALHMYNFVHVFGWDEHGGSTSYDVHLWTIPLEFRCSLYLFLVIIGTARLRTSIRFLTVGGIIWFSYRHSRWELCLFLCGMLLAETDHIRGAHIPLPALPQSEKQPRMSRGWAKSLFWTSVSVLGLYLMSQPDDGGEVAPGWVYLTSLIPGWWKVEKFRYWQSAGAVLFVLAVGHSRAWQRFFNSPVVQYFGKISYALYLMHGPAMHTVGYHWEKMAYGITGVEGYWYNIGFFLGAAFTIPTVIWWADVFWRAVDIPTVKFAKWFESKCITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVQ4</accession>
    <name>A0A7D5YVQ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase PIG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TP53I3</name>
        <name evidence="4" type="ORF">G6M90_00g076090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545492.1">
        <property type="nucleotide sequence ID" value="XM_014690006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVQ4"/>
    <dbReference type="GeneID" id="26241525"/>
    <dbReference type="KEGG" id="mbrn:26241525"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="35949" checksum="6AD638F610CF7FBC" modified="2021-02-10" version="1">MATMKAVEIKGGKGERDALFINAETPKPTAGTGQAIVKIKAFGINRMDIIQRRGLYPLPPQAPSTLGVEFSGVIESFGPGDHGSFNAGDPVLGLAYGGAYAEYIAVSSKMLLHKPDHMSFEQAAAVPEAWITATQALHSVLGFTAGKSVLWHAGASGVSIAGIQLSRAAGASEVYATAGSDDKCAFVTGEVGATAAFNYKTTDWAREIRDRTGGRGVDYIVDFVGADYFQKNLDVAARDGRIVLLGTLSGGKVPDADISQILYKRIRIEGSTLRSRDEEYQGRLRDRLETYCPEFASGKFKIVVDKVMPWEEIREAHKYMEDGKNTGKIVCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW21</accession>
    <name>A0A7D5YW21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7735 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g070470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540631.1">
        <property type="nucleotide sequence ID" value="XM_014685145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW21"/>
    <dbReference type="GeneID" id="26246504"/>
    <dbReference type="KEGG" id="mbrn:26246504"/>
    <dbReference type="OrthoDB" id="3561078at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056637">
        <property type="entry name" value="DUF7735"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24870">
        <property type="entry name" value="DUF7735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028872054" description="DUF7735 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7735" evidence="3">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="168" mass="16512" checksum="ABFD4F1A80C01511" modified="2021-02-10" version="1">MQTKTVLAALAGTAFAANLQPRQTDLGAATQCLDLLKTIPTPPPDLVKEWTTNPPKDYCSISIPASLSKDWSSYTSSASSWVKAHSSDLAKCPGAGQVTAKGPLDCKAGSGSATQATATSGSATGSATGSATGSAAGASQTTKTGAASRETGMAFAAVAAAGFALAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW81</accession>
    <name>A0A7D5YW81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g050640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545168.1">
        <property type="nucleotide sequence ID" value="XM_014689682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW81"/>
    <dbReference type="GeneID" id="26242509"/>
    <dbReference type="KEGG" id="mbrn:26242509"/>
    <dbReference type="OrthoDB" id="4938690at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="135" mass="15023" checksum="30A03C4281B20C2E" modified="2021-02-10" version="1">METTNDGLSPVEKLQRSGVQAGQTVVSGARPEQFADMIDFLARQLAGDEHRGLTTTAYIYDDVTRRRYMLRVTPLAAPPPPGSNIGDISARDYMDIVITFDTLDTLSRQVSDVIFVEGLRERFLVEVVRVAYTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWG1</accession>
    <name>A0A7D5YWG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g081910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543424.1">
        <property type="nucleotide sequence ID" value="XM_014687938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWG1"/>
    <dbReference type="GeneID" id="26243601"/>
    <dbReference type="KEGG" id="mbrn:26243601"/>
    <dbReference type="OrthoDB" id="5329488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028947426" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="17"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="229" mass="24343" checksum="702C3E1CF557C457" modified="2021-02-10" version="1">MLLVLITLALAATASAHSVISYPGWRGNSLITNDTFPYGMQWMYPCGGIGTTKNRTYWPTTGGALAFQPGWFRGHSLAVIYVNLGFGTNGPDHGPENMSNPMVHPFTIQGPTNNPYPGTICLPQIPLPINASVKAGDLATIQLVELAQHGAALFSCVDIIFADPGDPKIGEVNETNCFNSTDIGFAEMYTIATKMSGTDAYITSAAASLRALSWMGYVPLVVAGLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWW4</accession>
    <name>A0A7D5YWW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g107640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544078.2">
        <property type="nucleotide sequence ID" value="XM_014688592.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWW4"/>
    <dbReference type="GeneID" id="26243465"/>
    <dbReference type="KEGG" id="mbrn:26243465"/>
    <dbReference type="OrthoDB" id="4879292at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="63179" checksum="C6D757570C4BCD80" modified="2021-02-10" version="1">MSIIVSICDAEFWAEMTEQIASCVPPRCVLCTLQLKGNNDIFVASQANPAYQPAKYFACMVNCPHVNGLAYGCHSVCLRAGLPSLAAREVNCWDEDFSLSAGRSSDYQHHLLRNGNTMLDIARSAIQAEASITKACKAQIDTAHCIWATYVTLRGESYLSSLSNDPNGILLYDPIVKPAADIIYFARGPLGVQNILFACSADKVELETVRWNWWQDMPFSAGQSIYFDFDGLKIRNIHGNQGGNPKRPMWSAPSLQPSLVHFPLVQHSRPARFNRLMVNHPEITGYSIAWNTARRALTMVAHAPSSDLHCYDEFPERGTTWFYIALGSGELLKDIWRRDCHSHPHRGVDLIIATSLDNVYVVGPHENPNRRYSYSRLAVLRDGPNYMYIDDSVGFIRELAFDPEPGRNSNTWEDYMPVPISPNPGNNPNCWNISESFFYTSAPLDDLLGVNLCQFNDMVTGLLLHYGDGSQASVGEVRLDRLQSDRRQVPRNSTIRFTVSRTNYQCPYVNGLQIFTENMVKPPFNHGLDLEVNCHGILEWWFTRRQCQLAYGNRTSASTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX86</accession>
    <name>A0A7D5YX86_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g023750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548181.1">
        <property type="nucleotide sequence ID" value="XM_014692695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX86"/>
    <dbReference type="GeneID" id="26237625"/>
    <dbReference type="KEGG" id="mbrn:26237625"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11734">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssc1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="618"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="679" mass="73449" checksum="1C562556EE401089" modified="2021-02-10" version="1">MLASRLSRALPRATPITARSAAFARPLAPRFARYESTSAAEGEKVQGSVIGIDLGTTNSAVAIMEGKVPRIIENSEGARTTPSVVAFAEDGERLVGVAAKRQAVVNPENTLFATKRLIGRKFTDAEVQRDIKEVPYKIVQHSNGDAWVSARDQKYSPSQIGGFVLNKMKETAEAYLSKPVKNAVVTVPAYFNDAQRQSTKDAGQIAGLNVLRVVNEPTAAALAYGLEKEADRVVAVYDLGGGTFDISILEIQNGVFEVKSTNGDTHLGGEDFDIHLVRHMVADFKKTSGIDLSSDRMAIQRIREAAEKAKIELSSSLQTDINLPFITADSSGPKHINMKLTRAQLEKMVDPLITRTIEPVRKALKDSGLQAKEIQEVILVGGMTRMPKVAESVKSIFGRDPAKSVNPDEAVAIGAAIQGAVLSGEVKDLLLLDVTPLSLGIETLGGVFTRLINRNTTIPTKKSQVFSTAADFQTAVEIKVYQGERELVRDNKLLGNFQLVGIPPAHRGVPQVEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSDSEIQQMVEDSEKYAEADKGRKAAIEAANRADSVLNDTERALNEYADKLDKTEADGIKEKIAALREFVAKSQSGEGSATAEEIKEKTDELQMASLNLFDKMHKARNEASSGEQASGEQQQGEGEKKDENKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXE7</accession>
    <name>A0A7D5YXE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g087800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542335.2">
        <property type="nucleotide sequence ID" value="XM_014686849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXE7"/>
    <dbReference type="GeneID" id="26244849"/>
    <dbReference type="KEGG" id="mbrn:26244849"/>
    <dbReference type="OrthoDB" id="3557569at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="37"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="262" mass="29277" checksum="3476C26DFDBBA8B3" modified="2021-02-10" version="1">MGAFCHQTRLAAVRIPEKSNETLKLVKNAVAPKPAEFPLFSRLPPELRLKIWNLTLPSLRLVSIHCGAESPSLCNPQSRTTTTSFTGCTSNAAIPVNMHVCAESRAETFKSFRFAFGFVRTPGHIIFNPKSDILYFGPREGYMAADAQFHTCMSMCDPAQLALVRRIAISDALFWVDEMYSSMAAASLTTNVIKQLASRMPALEQIIFVPREQDEAIQPAFTEERMARQIQMAMHTVCQQDSHWRPPPWTIVSLQTLKTACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXI3</accession>
    <name>A0A7D5YXI3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular matrix protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546204.1">
        <property type="nucleotide sequence ID" value="XM_014690718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXI3"/>
    <dbReference type="GeneID" id="26240627"/>
    <dbReference type="KEGG" id="mbrn:26240627"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028967302" description="Extracellular matrix protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="22668" checksum="6B6E1911933E56F3" modified="2021-02-10" version="1">MKYALVISALAALATAAEKPKFLNSNFQIIEGQSFDLKFDGCEGGCTITLQDGPNTNLKDYKVISTSATGGSLAWVPEGVVSGTYAFKITNNANKEYNYSQQFSFLGTGATATVTPSAASTTGSSTDSATATASSTEASSTVSITASSTESSTESRTASTTTISTVTSSATAASGSSTTSAPSSATSHSSTSTRSTTAATTTVPNAGVRATPMAFVAGAVAALAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXN0</accession>
    <name>A0A7D5YXN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ILV1</name>
        <name evidence="15" type="ORF">G6M90_00g025690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548014.1">
        <property type="nucleotide sequence ID" value="XM_014692528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXN0"/>
    <dbReference type="GeneID" id="26237458"/>
    <dbReference type="KEGG" id="mbrn:26237458"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="396"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="494"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="575" mass="62897" checksum="467A9D61DB081E9C" modified="2021-02-10" version="1">MPSLLGHAEPNGVFQETNGHRRPETPAGRMALTDYSINPSPSSEEKRAKLRQAVPDDLLLPNGYPDYLRMIACATSRVYEACKVTPLSPAVNLSNRLECNVLLKREDTQPVFSFKLRGAYNKMAHLDPALSWKGVVCCSAGNHAQGVAYSARKLKIPATIIMPEGTPSIKHMNVARLGGHVVLHGADFDAAKEECARREKQDGLINIPPFDDPYVIAGQGTIGNELFGQVNMSKVEAIFCCAGGGGLIAGIGFYVKRMAPHVKIIAVEAYDANALAQSLRKGERVVLNEVGLFADGAAVKTLGEETFRICQDVVDEVVEVTTDEICAAIKDMYDDTRSGLEPAGALSIAGLKKYVSQHPSQDPNRTLVAVTSGANMNFDRLRFVAERAAVGEGKEVLLAITIPERPGAFAKLVDTIMPYAVTEFNYRFADQNVANVMIGLSLTAPPAKRNEELSMLIERIRAEDMVVTDLSGDELAKSHLRYLVGGRSGVANERLYMFSFPERPGALERFLKALRPRFTISLFHYRNYGGDIAKVLAGISCPEEDSGELAQFLKDVDYPFEECTNSEVFKTFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXS2</accession>
    <name>A0A7D5YXS2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmdA</name>
        <name evidence="1" type="ORF">G6M90_00g022610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548293.1">
        <property type="nucleotide sequence ID" value="XM_014692807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXS2"/>
    <dbReference type="GeneID" id="26237737"/>
    <dbReference type="KEGG" id="mbrn:26237737"/>
    <dbReference type="OrthoDB" id="3335528at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="34075" checksum="C5DF1D981ADC4B46" modified="2021-02-10" version="1">MAHAHINHSNIHFKWSKNIPPVLAVESGAELNFDLKDGFNNLIHPGTTAAQLRDLDTSQTDPAFGPVAVEGAEPGDVLRVDILELTPAPYGWTAVFPGFGLLSDEFPGPHLNVWDLSTIAEGYAEFKKGIRVPTQPFLGVMGLAPAQDGELSTIPPYNWGGNIDCKHITTGSSLYLPVQVAGALFSCGDGHAAQGDGEICGTAIETPMKARLRLTLEKDKPWVKSPHYLTSPEAKTRANSNRGQEYAAVGIDADLLEATKKGVRGAIDWLCAEKDLSREEAYMLCSVVGDLKIVEAVDMPHYAVACCIPLGIFVGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXW8</accession>
    <name>A0A7D5YXW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yanR</name>
        <name evidence="6" type="ORF">G6M90_00g007000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985662.1">
        <property type="nucleotide sequence ID" value="XM_066129623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXW8"/>
    <dbReference type="GeneID" id="26239254"/>
    <dbReference type="KEGG" id="mbrn:26239254"/>
    <dbReference type="OrthoDB" id="4937630at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="296"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="586" mass="65295" checksum="85D2EF0AB1B934AA" modified="2021-02-10" version="1">MAITTVTANLTPMLTPILIMLMLMLMFTPTARAPAIAITIATVTVKATAMVMMRVVTVDDLIVLHRQTECRYAHVANLLEETSRSAANGRRMTRPPKKKNVPDGPATIPNIADRGAINDHEGSSRGAAALSIGLLSHVPYSVTKASNVFGIGSEHPFANYWTCEGGLPEVISVLPDKAQADSLVARYFECVDPVYPMIHRQTFYADYEHFWRMKTDERNKMDPSFIALIFVILALGTQFVSSTTPKDRKQTAEFYASASNQALRMFSYLSSASIRSIQAMVLITYFLINDNHASDGWAFAGILIRQAYAMGLHRDPNIVTPNANPFEKQQRRKVWQAVLLQDTFLTVLLSLPPSATHTDVSVDDLLDDSSSIASSDPTDTAYIRGSWMLANLVQETICSPRSLDVPICTTVRHKSKLVADFRAVYRSFPDIFRSWDTDSLTAVASTNKRIVRQTLFLTSNYFHNLMLVHASESPDVPVNVRGTLEAAHDAISAFFLMFSLLESEARVWWVFNHRAFLEALCIANVLRETAKDAAGKDMLARDPLFVRARTDITRMIQIMELIGSNNDVARTRVQILSEFLEDTDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY33</accession>
    <name>A0A7D5YY33_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g035240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546918.1">
        <property type="nucleotide sequence ID" value="XM_014691432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY33"/>
    <dbReference type="GeneID" id="26239481"/>
    <dbReference type="KEGG" id="mbrn:26239481"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18872">
        <property type="entry name" value="NUDIX_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="495" mass="54460" checksum="8C3993AD0C46529B" modified="2021-02-10" version="1">MSQLKKRSVAVSFIFQFPKDDTTNTRPKVALFKRSDKVRTYQHKYAPVSGSIESFDVNPLTTAWREIQEETTLTPCSLTLFRQGKPYSFVDESIQREWTINPFGFILTCDPSKITIDWEHDDYAWFDPADVADDQKVDGVPKLLESLRRVWLEFDLGAAAPVLDASLTRLKGDHESGARQLAGIALGAFADVLKKSDISDKEVWWANARRAGWHLWKNGRESMGAPILSVVLAGLDVVREKTSEGLSADVVDDIVASLDELARQREASASRIANAFAAFLQQRPADGPIRILTLSSSSTIASCLTHALASIGHRLDLRILESRPLCEGAKLAYKLSSFAAEHNFSSRVDITVMTDAAAGIASQDVDLLLLGADLIDRHGNVSNKTGSLPAVLAARHVSNNVKVVVVSEKEKVLPFEAPGHEDNDAGEVTRGWDSVGVVRGQRPGGDVKVRNVYFEWVNNGLVDVYVTDEGISGTEDVMRWAADIERRAKDVFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY93</accession>
    <name>A0A7D5YY93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g031540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543092.1">
        <property type="nucleotide sequence ID" value="XM_014687606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY93"/>
    <dbReference type="GeneID" id="26243893"/>
    <dbReference type="KEGG" id="mbrn:26243893"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="444" mass="52597" checksum="66C17A7482CA1209" modified="2021-02-10" version="1">MSGSSGESLQIINTVEIGTGSFPQFTKLPPEIRSMIWTQSLCHERFIRVELLLGRSPQDLLDEDRPDYYIRLDAHILQELDARSNHRARLDRENSFLVVLRNRHEISKLFRVCSESRQSAMGFYRVKVPCYYKQLGEYPTEGTFYFNPELDFLDIVGLKFLPRFANTLLVNDPWHVGLINLGCVWRHARGYYDPLFQPIEGDEHLVRQLLSRLRRVIFGYNGHFGRGIQNRMAQRYGWKPQLHRSRPILASVSKFQRLPQDPRSVEAELTKTFLGYSDPRDQMYRWFRLLEHWQIEHPNHRVDYRYMVAVNNTRVTDRDEALFALREEKEEWNRCQEAYMANGVPCEEDDDELASAYGFWLFPINAFGRIPKANNRIRHIGRSYLESRPRVWKFGKAWDVSKESPELCLQYLPKVPLSEPEDNRTSRLWKSPKHRPCMRDRFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYB3</accession>
    <name>A0A7D5YYB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter cpaT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cpaT_0</name>
        <name evidence="10" type="ORF">G6M90_00g012810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549242.2">
        <property type="nucleotide sequence ID" value="XM_014693756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYB3"/>
    <dbReference type="GeneID" id="26238686"/>
    <dbReference type="KEGG" id="mbrn:26238686"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="70"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="572"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125928" checksum="5DDEC854F6B3DF33" modified="2021-02-10" version="1">MTEKYEAAASTLDPSACNPAVESRRKRTLGNVRLMHHDTNAMILVPTPSSDPNDPLNWPRWKKNYIAVVLCIAIAMCNFLAAGPTIAIVDTAIDFFPDAMKTNSLTTYAIPKVAYFFTTTALLQGTGNLFWVPMANKWGRRPVYIFSYLIYFGTSVWLIFDKSYGGFLAARILMGFGAGAAETIAPISIADVFFLHQRGRIMSLYTCFLSIGVAGGLVISGLITINHTWRTIYQVGSALVGFVLLLAIFTLPETAYPREKVVDTHSAGPTDENRSRGSSSSEVETGSKTVPKKRTYLQSLKIFCGTLTEENFFQMVIRPFGLILLPPVLWAALVQAATIGFLVAVTSNVDPAFEQTYYFKPYQVGLCFISAIIGSLLGIPAGGHFGDIVADHLTKRNGGIREPEMRLPAVSLSVLTSPLALVLYGVGIEHKLHWICPTIGLGLLNFSITQATNICLVYVIDAYRPVAGEVTLAVMGFKSLFGFLLSFETNPWINASGYQNAYGAMAGISAGVLILWIPLYFWGKKIRHATWKWRVLSFIHWNDDRESQLSIDYHASLRAPGMEQDSRATAKACDACRRRKLRCRRGISESLSDPRCIRCVRTGLQCTYNDERRPRGPKTGSRLRELRASQAIDSGEQTPFLPSSSRPSPPEITGWEEEMSEAGGRRDQSTDPVPYEFSEDYLDKVDLEQAHGADSIPHDFGLDQLLFVTPDTLPFDLEPAAPVSALQESELSVTSAAILHGNSIDISKDAIVAQVSQCFSAVYQRYPLWHLDTLVGKIEREECATDNEFRSTCLSIYLLNESSLFRKNPHHGSTRLLRLTEELETTRAHSNINHFADCPSTASVIVSLVLFIAHSVTDRHNLAFYYLNEAAGLLGLVDIDALDSLERALYRRLEAILFVTESASMPVYGKLRKNRMVPCPENLGALESSMRWYTEQHRPTCTLPAALSDIHLGSLDNKAVNLLHALVCLYNATTADEISKVSVPSPAVSEIIEQGVLGSTSLQAADVDITRQWQLCLRWRDVLSTRKSKSCSRSTPGAAYTLQIMGLTVLQYSRALRPGECRLVGHGKLASLATAIHDISSNLGILASCSSVIGDLIRTVCETDYEGFFAPQLSLVQLCIETVPRQLTFGEQDALVIDERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYN9</accession>
    <name>A0A7D5YYN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g011780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549344.1">
        <property type="nucleotide sequence ID" value="XM_014693858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYN9"/>
    <dbReference type="GeneID" id="26238788"/>
    <dbReference type="KEGG" id="mbrn:26238788"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF187">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57975" checksum="6D182D8D9E5CF9E4" modified="2021-02-10" version="1">MSAEKPESLPKDMTPNKIEAQTAVSSDGESLQDHNGYLVDAHFASRNIQTTPDGNTILIPQPSKDPNDPLNWTWGKKHLFLFIIAATSLLPDYGSATGAVTLLPQAEIWHMDPDVVNHSQVGNVFMIGAGGIVAICLGAYFGRLPVMFWFMILALGTALWCTAAETFESFMAARILNGFFSPVAEAGGLMFIKDMFFFHEHARKINIWASFIVLSPYFGPLFSAFIIDTQKWQWAFGLYTIMTGICVAAIFALLDETYYDRKLPPSEQPQRRSRVLRVIGVEQWHTRHLRNTFTEAMSRPFIVLAKLPVLISNTYYLLAFAWVVGINTTLAIFLTPLYKFGPKQIGFFYFTPIVAAILGEIAGHWLHDLVAKWYQRRNNGRLEPEARLAVVGISTPFLCSGLILLGFSLERAYHYMLAALGWGLYVFGIMITTVGVNAYNLDAYPTASGEVAGWLNLSRVAGGFIISYFQVRWAEDMGAIKSFGIQAAICFGALFLIVLLQLYGKQLREWSGQPHFKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYU4</accession>
    <name>A0A7D5YYU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MON1</name>
        <name evidence="9" type="ORF">G6M90_00g103460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546002.1">
        <property type="nucleotide sequence ID" value="XM_014690516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYU4"/>
    <dbReference type="GeneID" id="26240425"/>
    <dbReference type="KEGG" id="mbrn:26240425"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="180"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="342"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="489"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="599" mass="65465" checksum="B03947927812F82B" modified="2021-02-10" version="1">MGRETKPPTEEEEQPPPLPPRKAVATTAESRGLQAQPTTALTSVDIQTLSFPDGTRGTFSTPGNRSVSTPVGSGYDSPGYKASLSGGEGPDDAASMMSFAPTMRPAGDIASLMVSDFHKRTPAWNLLQAQSATVQPFQRHLSGAQDGLAGFEDEFQPIPSQEDENVKDEERVLMWKSKLKHYMILSSAGKPIWSRHGDLDLINSSIGVIQTIISFYEGAKNPLQGFTAGSTRFVVLTQGPLHLVAISKLGESDAQLRSQLEALYMQILSTLTLPTLKNIFVNRPSSDLRKPLQGTESLLSSLADTFTLGSASTLLGSLECLKLRKSERHAINNTFLKLRTDKLLYGLIVAGGKLVSVVRPRRHSLHPSDLRLIFNMLFESDGIKGGGGENWIPICLPAFNNKGYLYMYVSFFEDSPEVQPPGSPTNVQTPSEEIAMILISADKESFFSLKQMRDDVAQALAKSGSLATIRKAARAGRPAVSQVAPGSQVSHFLYKSRANVQFCMSSLQPLFAHVVERRRLLSLYHELHASVHAKHAHLKVLHCSSEEATCLAWITPVFEFYCIGGPNLSRAAMTQGANKIIQWAKKEEQRIFIIGGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ71</accession>
    <name>A0A7D5YZ71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase CLM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CLM2_0</name>
        <name evidence="11" type="ORF">G6M90_00g055790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544172.1">
        <property type="nucleotide sequence ID" value="XM_014688686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ71"/>
    <dbReference type="GeneID" id="26242584"/>
    <dbReference type="KEGG" id="mbrn:26242584"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59461" checksum="1B8C3A600369A061" modified="2021-02-10" version="1">MTSVLITGVCVTAMTYCIYLAVFRKRHAHNLPPGPRGLPILGNMRDFPPGGRPEYQHWIAHKDLYGPVSSVRVLGQTIVLVHDRDAAHELLTRTSSKSSDRPTSEFATNLCGYGRLFVLRGDDARFRRCRKMVHQHLGTAASASRFDEAQDAATRRYLLQVLNSPNSLFRHLANHAGGSVLRITYGYATSSAAEADPLIELIELSVSQLGLAIVPGAWAVDVVPALKYLPAWCPGAGFQQTARRFGKVAQQMASVPFEFVLGRMASGTQRESFVSRLVAQHREAAPGGTLTPRDEDEIKTTAAVMYLGGSDTIVTALRVFVLCMILFPGVQRRAQEEIDSVLGPRRLPAASDRHRLPYVDALVKEAYRWSPAVPLGLAHATSEEAVCGGYRIPKGAIIMPAVWWFLHDPDVYPRPGDFDPERFLEPRNERDPRLDAFGYGRRLCPGRYVADTILYLTFAQTLAAFDIGKAVDGQGKEIDVELELGCGVACFPKEFPYAIAPRSPAHADMIRRMDAGRLGEATDLDCLDIRAMMRKWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z037</accession>
    <name>A0A7D5Z037_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g045680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986331.1">
        <property type="nucleotide sequence ID" value="XM_066130399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z037"/>
    <dbReference type="GeneID" id="90967722"/>
    <dbReference type="KEGG" id="mbrn:90967722"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="44" mass="5109" checksum="4D30D2DA687D6BA8" modified="2021-02-10" version="1">MSTVNEVNKKNENLWLVSMPQLHTAAMAEFMSLRRWTVLILGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z067</accession>
    <name>A0A7D5Z067_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">20-hydroxy-prefusarin hydrolase FUS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FUS2_3</name>
        <name evidence="3" type="ORF">G6M90_00g110760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543783.1">
        <property type="nucleotide sequence ID" value="XM_014688297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z067"/>
    <dbReference type="GeneID" id="26243170"/>
    <dbReference type="KEGG" id="mbrn:26243170"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="170"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="408" mass="45423" checksum="91DDBE40C6573FAD" modified="2021-02-10" version="1">MADPNATMYQLSKDSDFHFGILRALAMAPFDGSDIDECLGAANSIVPGDFESFATSFLSIANTVYKRGLSIAKTKFPISARTAFFSAATYFRSADFYLHGNPADPRIMDYWAKQTEAFDQGLALLSPPGARLTIKTPEFDIPCIWITPDHEVKQRPTIIMGNGYDGSQEEMYHVAGVAALERGYNVLTYEGPGQPSPRRYQNKGFIAEWEKVVTPILDHVLNMTKSVDPTAVALYGLSLGGYMAPRAAAFDHRFAAIMALDGVWDFGAVIRHDFGPDAMQIYDSGDKAKFDQLAQQYLKPGVRTRLRWGLEQGMWAFNTTSPFEFVTRVQKFSLAKVAHQIRTPALIGDAEGDIFFKGQAQQLAQAIGKWATLYQFKNKDSIGTHSGIGALKQHNQVIYDWFEDILHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0A3</accession>
    <name>A0A7D5Z0A3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g047160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544837.1">
        <property type="nucleotide sequence ID" value="XM_014689351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0A3"/>
    <dbReference type="GeneID" id="26242178"/>
    <dbReference type="KEGG" id="mbrn:26242178"/>
    <dbReference type="OrthoDB" id="4936712at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="58814" checksum="5F0B7E907D3FDDE1" modified="2021-02-10" version="1">MPSTSQTDHKPSSHSADTERTTFHNAHVSLSQDANSPLNESTELTQGSLPILLPRTYQPPAPRFQNKAISPGQPPDTPDPRFRLCVKIPCSDTNLSPISRLVSTSGAQHPRMEDGLRPGGIQSMCASIIGDATMEDISLRPNEAPSPGILFGPRRSPQGLADRRGLRTSSLDWKRYSSPQHHSFDARTNTPTHSRTVSSGSSTRYARDSLMSPVLYARYLENDPFTQGRHHSSSTSQEKLTLPTPIPDSPTLGHEHEESDLFADTSRDEIHEEQSFDLLKTYMRSRRNRTKHSNDGTAPPTSANQSATKTLGSKHRGVHWYSSSFALNKVKSHEAFTLLPQPSPASNQRIHSSRPPDISTLPLNYPFRKPAKTCGISDKSTALALQIFDTTSRLASVANKRDSILSITPRPNQSCDAQKQSCVPKPSRLGSLFSRHIRSGSSGSSAAEFQAPVANASSTNEKAPRDPGSSRDHVELQDESASVYSQPSMLETQVQEQHPRVASAGSYSYTTSTSSIAGIRDKLKLKMAPSQVKQQPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0G3</accession>
    <name>A0A7D5Z0G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g029830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985582.1">
        <property type="nucleotide sequence ID" value="XM_066130042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0G3"/>
    <dbReference type="GeneID" id="26245824"/>
    <dbReference type="KEGG" id="mbrn:26245824"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF7">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="437" mass="48601" checksum="6D9C691BED5CF43C" modified="2021-02-10" version="1">MPSHVYDVIVVGGGAIGLGAAYEVAKAGKSILVLEQSCLFNASGSSNDLARMYRTMYTEPFMAELAYKSMGIWNELEMDAGTSLRVMSGLLNFGDATMGADTPEGTLMGPIANLEKLGMPFRRMTKKEMENEYPFKKLPEAWEGIFAPDNGVINVPLLVRTLARLAKDYGAHTKQYTEVKKLVPVKDNGEDTWRVETRVNGDEAVLFRARKIIIAAGAYTNHVVQPSFNFKLKLNIWEMVASYFSVNAGPSGTLFPSMWFQFANDKHGRSRLFYGFPTVEWGPPNVCRIAVDAATRQITDPSLRCGSVVNPEDIHDTQQFIKEHLVGVDHMTPAYTLSCLQTNTFDNMFVLDYIPEQYLQGGARDSVAVFTAGWAMKFVPLIGRALKDMVLNGHSEYALDEFKIDRLDPKSKGKYGKPQAGIIDEVDADFANSWEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1C7</accession>
    <name>A0A7D5Z1C7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g034950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546890.1">
        <property type="nucleotide sequence ID" value="XM_014691404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1C7"/>
    <dbReference type="GeneID" id="26239453"/>
    <dbReference type="KEGG" id="mbrn:26239453"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI68343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="861" mass="92732" checksum="2ECADB5128B6B6C3" modified="2021-02-10" version="1">MPVPKKEGASSGGGAARADGRGQNGNRSNFRTDTAISNSRLGNERTLQPWIPDAADGVDGSLEATAASGHWDQFAANEKLFGLRTDYDESLYTTAINKTHPQFRERVAAADKKAKEIERSVATTAHVAEERVMDYAGGTGAGAQNEEDKYSGVLRQDFPPLSGGGRENRYTPPAKRAPTSQSTVKGAPVDPAIISSQLKAPVKRQAASTEQTRPQASEGIKNGVPVKAEPPKASTPKTTEETPTESKPSPVLNLPAESQTPESKTTEKVTTTGPSSTSSSRNASSQPKEQTPSATATVEHDVLNSFRSFASRERDNLEKVRSHKARADKEVKLNELKNFSISFKLSTPVPKDLVSIIAKDPAKQKEIQAKAMKNAEDMAKTKADSGSKDKAQPVKDSVTAKTPDTNTSANTSDGRSSRSAVVPQASGPAGNGSRHTAPRQYSQQPFHAQPFRSNRGPQQQTGNLAQRLRNVEQQRYSQPPVTTSHNLGHEMRAPPTGPSGNVDSGFNRRLSGAPGQMGAKLNPNSHEFRPSPFAATFNPNSHASAGSSPRTSVNHVAESPVPTAPQTPVIRRKTKKVDVSKCLILSHIRTVAPPAGRNWDDNGGLRPSFDTLPTWRQLKDDEKPESTMHLTYTEHFDRQPFNGPSAATPNPTHVVPQMPHQHQLPFHLQHGAHGLGTRQSPHMAPMQMHAPQHGPVPIPPYGTEDHRMMPSNSAQSFASPRMGQLPVAYPGQVPYQQPVFMGPGNPQMGQYRSFSNNPHYVPHQQSQMAGPMIMQPQFIHPQGMVAAPQMMYHGGHPQYMPPTGPPQPGPGGSGYPSPGRPTAPVMMHQGSQQGQPVYGMSPSVQYNQPAYGPGQPSGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1K2</accession>
    <name>A0A7D5Z1K2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g025290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548054.1">
        <property type="nucleotide sequence ID" value="XM_014692568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1K2"/>
    <dbReference type="GeneID" id="26237498"/>
    <dbReference type="KEGG" id="mbrn:26237498"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="66"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="33896" checksum="6CEA22EF6C06EBEF" modified="2021-02-10" version="1">MWSAGFIALVFYVFLGANLFSRRSPYFHDRGAPPAGAWADGPLKLVDTPWTLHQKNDLFTTAATHMALLHNAIVRGYNSIYLQAPHVRGDDVPDFAAYALTWHKFLVSHHDDEEDKLFPDMAGILRDDGIWGNMTQEHESFLPGLAAFQALLNTTDATAYDAGALRGVMDSFAADLSAHLHNEVAVMAAMAAHENAPARESLRGALAGDMLKAWGKNTVTKAGYVDVLPFFLLNTDRTFEGGVWRNWPRMPEAVRWSMVNLVGMRHGPRWRFSSCDAAGRPRELFALKALREEKEREKERSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1P0</accession>
    <name>A0A7D5Z1P0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cutinase transcription factor 1 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CTF1-A_0</name>
        <name evidence="9" type="ORF">G6M90_00g007660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985807.1">
        <property type="nucleotide sequence ID" value="XM_066129633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1P0"/>
    <dbReference type="GeneID" id="26239188"/>
    <dbReference type="KEGG" id="mbrn:26239188"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
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        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="899" mass="100322" checksum="4B1F14EA65F8CB4F" modified="2021-02-10" version="1">MDVEMTAGDAGQQQSLTQQSESSAKASPPAANNAGSNAANQMSFRRQRASRACETCHARKVRCDAASLGVPCTNCVAFQIECRIPTPKRKKAQNAGNQTTKDSDSDREADDRPHQTTPGSASSYPRPPTVSHTSDGTPSSSMTEAQVRQEEVDSGTYLNLVMKPKFTRAPITEAGRVAFLGESSNLTLLVHDRQGSSDVVHYPLPENVRGSRARLTELDNVEIEILHQRGAFLLPPRSLCDELIEAYFKWVHPIVPVINRSRFMRQYRDPKNPPSLLLLQAVLLAGSRVCTNAQLMDANGSTTPAALTFYKRAKALYDANYEDDRVTIVQSLLLMGWYWEGPEDVTKNVFYWSRVATIVAQGSGMHRSVEQSQLSKSDKRLWKRIWWTLFTRDRSVAVALGRPVHINLDDSDVEMLTEDDFIEDEMDRASEFPPDPIHVQFFLQYVKLCEIMGLVLSQQYSVASKGRQRNAIDLTHSDMALADWLQNCPKIVYWEMPRHHFWSALLHSNYYTTLCLLHRAHMPPSGSRSFPDDSPYPSRNIAFQAAAMITSIIENLATHKELRYCPAFIVYSLFSALIMHVYQMRSPVPSIQQVTQDRMRSCMQALKEVSRVWLVGKMVYALFESIIGNKMLEERLQKAGGKRHRKMQQSLSQLEQQSKVQDVSKRKYDDMAIDFTANAPTPQESYERSRPQTPSAIKTENTSAMQPPAVASPNSRPSVADTFMGGTNSRPQTRPATPFNPSFSVPATPPDLYLVTRNSPNLSQSLWENFQPDQLFPESSSMPAFPNLSPTQTHQEPNHNLMAQMTPNSMSQGQASNQFQATGQGQGNGGVPTQGFHASAGMWHTNFDGGVHDGQSPDSWSTSSVQGQPAPTTLNVEDWFQFFGINGDASNLNLDVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2E6</accession>
    <name>A0A7D5Z2E6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like F-box</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g031030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539636.1">
        <property type="nucleotide sequence ID" value="XM_014684150.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247547"/>
    <dbReference type="KEGG" id="mbrn:26247547"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39697" checksum="5E9E76AB6A0BE7DC" modified="2021-02-10" version="1">MEPSSPDAASFTLCPIIQDLVRTRFAVPGSIFLVEDIQTIALTESRRWQVIRLLLGDGELCIQALLADSMHRFVHTRDITVGSYVCVQDFQLRQRTTAADAGKPQQQMVYLVVHDVKTLGCNDDVRRMHDEQQLADEAASPAGSGASTPTKPEPAGQAPGDGDEFEDDDDDDDMEGAFDEFEALAFPASKTPAPAHPSKPALPVALPRDWHDVQTPLKLTTLRAIPNLPYRQNWSCNVLAIVASLSAVESCHLPPYRQRTARITDPSTAKQVHLAVFLDPDEFNPRVGSAVLLTGVKNHRFDGGSLKKYASDRGRGRWWFQDPWELAWCDVRGIKDWWAEMEAYFASQLSEEVVGGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2U8</accession>
    <name>A0A7D5Z2U8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor tau 55 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g013700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549152.1">
        <property type="nucleotide sequence ID" value="XM_014693666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2U8"/>
    <dbReference type="GeneID" id="26238596"/>
    <dbReference type="KEGG" id="mbrn:26238596"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34177" checksum="A944B05675A5FC04" modified="2021-02-10" version="1">MPLEKIYVVRHGFRSSWSVDPRTGVYLGIPSPTGIQGDPALTSYGIDQAKELGRHLETLDPAVEKVYSSPFYRCLQTMVPFMDLQREKPGAQNGQMPQVSAGESDETAKSLLTGGTVVTKMLPEHGIREWFGSAPFDHPEPAAPGVLKAMFPSYDESYTSAARPSRKGETLEQLQQRITVALRAIIQQCDADGTRAIVLCSHAAVIILIGRILTGLIPASVDVDDFQAYTCGLSVYSRSSGGVAEGNNISDTRDARHSTSSSTPDTLQANRIGGWDCELNSDCSFLSGGAERGWKFTGDESFPDTGSLSQVEPGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4E4</accession>
    <name>A0A7D5Z4E4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g092010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987483.1">
        <property type="nucleotide sequence ID" value="XM_066131412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4E4"/>
    <dbReference type="GeneID" id="26245313"/>
    <dbReference type="KEGG" id="mbrn:26245313"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI72485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="375" mass="39262" checksum="B1D7C0FB849CAC47" modified="2021-02-10" version="1">MEVSSSFSSRRSAAGSLPPFSLPPPNEVPRASDGLSPGLSSVNTASSQGSQAHGNMQYTYSANVHGTWPTPGTSNYSVGGTSPDQSYGGHRSSIYGQPPTMGFGNPRSSQSPATGGEGLPPPPFNGVHQPFQTSISGGGGSGGQDGHHISGQAPPQGAMLSSTQPHAAGSAPAPVDPYSHSRPPSNPSYYPASSATQQASFSSYAGPQQPSPTGTSPGSRGLGHSAMAPPYRPYGSYQPLTTMNGPVMSNIHQPGSQLSMIPAMGVPPGYNHQMMYGHHPQPQPQSERPFKCDQCTQSFSRNHDLKRHKRIHLAVKPFPCSFCSKSFSRKDALKRHRLVKGCENKSNEAAAADDAAAQERAGEGDDDRSSLGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4K7</accession>
    <name>A0A7D5Z4K7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TTC1</name>
        <name evidence="2" type="ORF">G6M90_00g073710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545694.1">
        <property type="nucleotide sequence ID" value="XM_014690208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4K7"/>
    <dbReference type="GeneID" id="26241727"/>
    <dbReference type="KEGG" id="mbrn:26241727"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="288" mass="31150" checksum="AC4232AB127191BC" modified="2021-02-10" version="1">MAESAGHDPSDVGTVPEIVRFSVEEEQALVAESNSIKAEANALYSSRDYENALAKYEHAILSCPNYLHYERAVIQSNMAACHLQTEQWTEAIKIASKALDGLVELEKTDPGLCNSMSNLKKSDSSDKESSEASLTDPDGVDDEIISSGASRAAPAPSPPQNSFLETRKADIRRIRTKALLRRARARSEAGGWQHLAGAEEDYKTLSTMPGLGAADLRTVQSQLKTLPPRTKAAQEKEMSEMWGKLKTLGDGILKPFGLSTDNFQMAKDGKTGGYSMNFTSGGESSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z570</accession>
    <name>A0A7D5Z570_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetyltransferase PaAT-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PaAT-1_4</name>
        <name evidence="4" type="ORF">G6M90_00g105500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541537.1">
        <property type="nucleotide sequence ID" value="XM_014686051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z570"/>
    <dbReference type="GeneID" id="26245787"/>
    <dbReference type="KEGG" id="mbrn:26245787"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="70"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="505" mass="57155" checksum="BDC723FB92C72A4C" modified="2021-02-10" version="1">MPAQNSPRLLDRGSLEEAMLNADPEAANDGPLPTHWTSKPSGDTSTSLSRIKSRLWPQPAHRPRALHKTAYLDGLRGFAALLVYWHHHVLWVHNADRLAQNPIFENSFGYASKYHLAALPGVRLLFSGGHFAVSTFFVLSGYVLSIKPLRLIESDDLAGLVDHLASAIFRRWLRLFLPVAATMAVYATSWHLLGLWVDGASPQGSWLGEMWFLYCEFKNFSFVFKDGGVPWLSYSMHVWSIPVEFKGSVVVFASLLAFSRCTLAARLWCQVGLVVYFMYVADGWYCAMFVAGMLLSHLDLLAALGRLPRFLARLAPYKTVVCYHMLVLGIYLGGVPCENRELDQLARNRGWYFLSFFKPQAVFDYKWFYLFWAATLLVSSVSHIGWLKRFFETRVCQYLGRISFALYLVHGPLLWTLGDRLYAAVGFKGPGQLEHMPQWVDRFVLPQNGPVGLEFAFVLPHLILLPVTLCAADFVTRAVDRPSVEFAAWVYRKTLPSVPRKHAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5A0</accession>
    <name>A0A7D5Z5A0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 finger domain transcription factor dvrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dvrA</name>
        <name evidence="12" type="ORF">G6M90_00g055080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540898.1">
        <property type="nucleotide sequence ID" value="XM_014685412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5A0"/>
    <dbReference type="GeneID" id="26246204"/>
    <dbReference type="KEGG" id="mbrn:26246204"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF32">
        <property type="entry name" value="ZINC FINGER PROTEIN RST2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
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        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
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        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
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        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="710" mass="76814" checksum="D8B87DF1E5BC4F92" modified="2021-02-10" version="1">MAGAFRPVNSSLLGESIKEEPMTTCSSSSVTPRPSAASHHPPQPQQSRTLPDDSKTPTRSTFSSAVSDQKPLPNAPFPPTGQASESADGMPRRENSQHSTKSSRRDSMDVDMDDSDGDTGAGGDDGTISDGDSVGADGSKSNKKKKSQRFYCTDYPPCNLSFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNEDIPTDSLAATGSRFQRQMRTTERVRQAGNRARASTGGSAGGPVRGHSKSLSTSSIASISSVGSGYGPQMDVRRRPPPLVMAADPRSRMSLESYRSNADSTFSYRPPSPGDFSTPTSATFSTAQSSPRWMSGMASPTSSHSRSQSMYSSGNRTPGRRLSVPSSANPFQSAPGRALFSAGQMNSSHPSAFSPAGSSLVPSPTSTTSGWSTRRDSVSSAGDDAWRRRTWHPDSRNYGNQPPQTQSNQLAGVNQSVGPNPPPPIANPSSSQSSLRLPGIESFDPLPRRHPTPPPPQPQQQHGPSAMAIDSETAYRRSFQPGVGETIQPDERRNLNMYDASLQRGLNRLDISHKTPPRDSAGSWASEANRAVQAQAERVQMQVNQPSVRFQDQVPPSRQFPASVHSGRSLHQHTMSAPSIATPRENKRHGWYHGPAPSQAHSEHVMQDPRGAHVDRMVHPNFTGFNGFPGREQPAQTQQQDGKANPDSLRRLEALVAVATSEGTTATAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5D9</accession>
    <name>A0A7D5Z5D9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g107910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544053.1">
        <property type="nucleotide sequence ID" value="XM_014688567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5D9"/>
    <dbReference type="GeneID" id="26243440"/>
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    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="163" mass="18439" checksum="190B6DE2C2FDB6F6" modified="2021-02-10" version="1">MDQQAKPVDAEQPPALNLLGQIVARLSEYGQNATSNISQGFNSMTLQSWIRIVVIAGGYMLLRPYFLKAVTKGAVEKMERDDRAARGEDDKLPHPELTPNEYRGIKEKLYADDDNAGADGTSSDWGQKARVRQRKMLRELLEDDERRRAALDEDADIQEFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5T1</accession>
    <name>A0A7D5Z5T1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hemeolysin E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g032580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5T1"/>
    <dbReference type="GeneID" id="26243990"/>
    <dbReference type="KEGG" id="mbrn:26243990"/>
    <dbReference type="OrthoDB" id="4494488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="ClyA_Cry6Aa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Enterotoxin_cmpnt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38443">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38443:SF2">
        <property type="entry name" value="NON-HEMOLYTIC ENTEROTOXIN LYTIC COMPONENT L1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47585" checksum="BF0DE03D8E417EF1" modified="2021-02-10" version="1">MTGFDPRQPITDPSVFSPRGMYVDNRSGNRGAQGDDDDDVKAFVFDASDMKALNRFLGTGRKLQTTRSEYLRWLGITDTPGEISAALGKELESLLKTYTSIKSDCTQFKDVTWNRIVDIAGDIKSYATMSGGKESTSYYVLMLKFIGDYHEENKKPNPDKAKLAELKESIEFTVDAELKKLGELQAGAQEALTGLGAFERVCEQHSLAVETNANSLEAQLKKEGNDIETMKKKIEEARAEIDDLQGQIDGKNQAINDAPKYMWVWPIGTAIGTGIVVEAKKAIKRLKEAMEKVKKVLDDYESKMKTASRLETNLKFISKQVKDLGTEIGPAIKTLQKLQGAWKSMETDLSAIKDLIEFDTDNIPPMLITKPQLEGIVDEWNELKNYASNYIENAYISDEPKAVSIAEYISELEDAIMRIEAMEKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6K9</accession>
    <name>A0A7D5Z6K9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAGA-associated factor 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sgf29</name>
        <name evidence="3" type="ORF">G6M90_00g079910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539533.1">
        <property type="nucleotide sequence ID" value="XM_014684047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6K9"/>
    <dbReference type="GeneID" id="26247697"/>
    <dbReference type="KEGG" id="mbrn:26247697"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="267"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="42860" checksum="AF90D60F670ED0C4" modified="2021-02-10" version="1">MTDKKRQRRNELDNLREDLGPYYHRPSPRSDSVDTVSNHNRTNSGGGVTGSPGSGIMSQRNRSGRGSNRSNGNNSHGEEAQIWDSCKSQLAEIVSGINAENDNLSELVDMDKTVGATDPEKIPNDSLKQMEQLCRNGVKFSEANVASIKAVMEQLKIMRAVIVAKEQAEGGSSAPTGKRNARDSAAAAAASLYDFDGAGDSPVPSPIGGSSRKYGDRSSNRDRDSMPPKADSVEPQGSSGTGNGGGPSGSTASGSAAAAAAAASNKSKVVFSKGDPVAFKPRTGGEGVSDWIMGEVAQVLGEGKSRRYKVLDIEPDDQSKQKEYRTSASSMIPITPESQASTLKDWEAGQVVLALYPNTTTFYKAEVHSMDSQGRVALKFEGENDSTTLQQVERRFVIEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6M6</accession>
    <name>A0A7D5Z6M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g031920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543127.1">
        <property type="nucleotide sequence ID" value="XM_014687641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6M6"/>
    <dbReference type="GeneID" id="26243928"/>
    <dbReference type="KEGG" id="mbrn:26243928"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8643" checksum="CDEDB4DFEEB5F8DE" modified="2021-02-10" version="1">MLSRAAARTTTSLVSRRGFHATRARMSSPYHYPEGPYTNIPFNPRSKWFGAGYWAFMATGFLAPFGIAVYQTYKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6W4</accession>
    <name>A0A7D5Z6W4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter prlL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prlL_7</name>
        <name evidence="9" type="ORF">G6M90_00g110930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543767.1">
        <property type="nucleotide sequence ID" value="XM_014688281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6W4"/>
    <dbReference type="GeneID" id="26243154"/>
    <dbReference type="KEGG" id="mbrn:26243154"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="53"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="511" mass="56105" checksum="1B8DA4CAF9BECF4F" modified="2021-02-10" version="1">MDPSASSTATNTARLSADSTRPAEDAVFDYLPASQEEYAAVEKELVRRIDWTLMPVMISMIVLNYLDRNALPNARIQGIEKDLHLQGNQFNICISVLFAGYLTLQIPSNLILTRVRPSIYLPTCMALWGVVSASTAAVHDFRGLVICRFFLGFLEAPFFPGALFLLSSWYTPRELATRTAVMYTGSLLSSAFGGLVGAGVQYGLDGARGLHAWQWMFVIEGAATVAVSLASIFVLPDFPATTAWLSSQQRAVAMHRLRVHSGSVDEEKGSVLQGLRMALLDYKVWLLTLIVILKTSAAAVTAFIPTLVATFNFGKIESLLMTAPPYVFAAVVAMAVSVASDKLEERYWHLVCPLAVGMVGFIVAACTHSLAPRYFSLFLMLGGVYGCFDITYAWLSSTLPRPLEKRSAAFAITNMVGNIAQVYSPYLYDKSTGPQYLPAMISNSAFVFGSMVAATALLFCLKWENRKLDEAEAVLDEEPRREDDAPAKSTSIVESRFEGTVKLNRGFRYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6Z0</accession>
    <name>A0A7D5Z6Z0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent monooxygenase DEP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DEP4_1</name>
        <name evidence="4" type="ORF">G6M90_00g093620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540729.1">
        <property type="nucleotide sequence ID" value="XM_014685243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6Z0"/>
    <dbReference type="GeneID" id="26246342"/>
    <dbReference type="KEGG" id="mbrn:26246342"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="215" mass="23401" checksum="3B844466739C54BD" modified="2021-02-10" version="1">MKNGNGEDYDVLVVAGGMYRLITAYTYLKLAPETNLLILDDGRSAGSGAPSASTQTFLHRSATKTGLSPDWYISSQTIHNYLQSFAEDHDLVRRIHLPQKVAKANKIGGKWVLTLNDGASQASGAKLIVATGVTSGAYVPEFPQKGFHKPILHSSELGKYISSLIGPNIQRVTVLGAAKSAYDTAFMLIKVGKQLDWINRENGSEVRKEPLTRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z856</accession>
    <name>A0A7D5Z856_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539962.1">
        <property type="nucleotide sequence ID" value="XM_014684476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z856"/>
    <dbReference type="GeneID" id="26247182"/>
    <dbReference type="KEGG" id="mbrn:26247182"/>
    <dbReference type="OrthoDB" id="4940353at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="39312" checksum="75FD917DDD26B412" modified="2021-02-10" version="1">MSTWFTVLARVVEVGRIQDSPYRNALCEFEEGSSDVTTGDWRSFHIAFYGDLLDTGRAYMIRGQARLPGNDEAEAPKFTAFDAIPLATDYLPIHQLRINAAAELTCTPRFVDATRTFEFEAKLTGYYGDPAPPVLRNDRVFKASQTRTKTQYIYAEQSPKFDRTLGSENLRAQSRLFIDGFYTFPDEETQQPGYLDLLAVSFNSTNKDPANSVGSPAKGGSSRRRDVPLKISPAKQTNMRRMPAPVTPPNARLPLHSGSSASTPHTVSDTFTPGRASTAPSLTMDDGSRRGLIVDFEVLESGPGAQVDHSAMSSFAPDGLQNKRQATEPSQEPSSKRSRKPSQKAKEMLTEDELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8P5</accession>
    <name>A0A7D5Z8P5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SPB4</name>
        <name evidence="21" type="ORF">G6M90_00g071680</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545891.1">
        <property type="nucleotide sequence ID" value="XM_014690405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8P5"/>
    <dbReference type="GeneID" id="26241924"/>
    <dbReference type="KEGG" id="mbrn:26241924"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="46"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="283"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="535"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="565"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI70508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="627" mass="70576" checksum="5A7EFF499E10464D" modified="2021-02-10" version="1">MAPGKVIRKRDPRAWESLTPPLAEWILDAVSTMGFSRMTPVQAATMPHFLGNKDVVVEAVTGSGKTLSFLIPIVQRILRLEEPTKKHHVAAIIVSPTRELAAQIHSVLLSLLAFHPPSAEILPNLNDEEKRPSTTTPVIVPQLLVGGTTTTAQDLSYFMRHSPNVLISSPGRLVELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKQDLQNIISHLPKQRRTGLFSASVSEAVGEIIRVGLRNPVKIEVRVKMKDGGVLEDRKTPASLQMAYLIKPATQKLPALAQLLEKLPITPQRTIVFLSTCAAVDYFQHVLSGLLPAQFSLIPLHGKHPAKVREKNFNRFLNSVSPTVLLTTDLAARGLDIPQVDLVVQIDAPSDPKVFIHRSGRAGRAGRKGLAVVMLHPGREEDYVRFLEIRKTPITPLEKPEISISEKDAAAAVDQIRKLAKTDRAIYDKAQKAFVSWVRSYGAHQATSIFRVSDLDWIDLANAWGLLRMPRMPELKNWKGDKTLGVEMDWDTFAYKEKTREMARIEEMEAAKNGEGIEKKDDKKRKRKNEAWSGKHQQQEHRNERREKRYKKKEAEKNATMTDDQKLDKMKLDELIKQVREQNRTNAASKDDEFEGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9L2</accession>
    <name>A0A7D5Z9L2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="17">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RAT1</name>
        <name evidence="21" type="ORF">G6M90_00g072920</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="17"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986962.1">
        <property type="nucleotide sequence ID" value="XM_066130975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9L2"/>
    <dbReference type="GeneID" id="26241803"/>
    <dbReference type="KEGG" id="mbrn:26241803"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="20">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="411"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="506"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="873" mass="99017" checksum="99750352FC4C5D5C" modified="2021-02-10" version="1">MGIPAAFRWLSNKYPKIISPVIEDQPVVMPDGSIVPVDTSSRNPNGEEFDNLYLDMNGIVHPCSHPEDKPAPEDEEAMMLEVFKYTDRVVNMVRPRKLLMIAVDGVAPRAKMNQQRSRRFRSAQDAKEKEENKKELLKLVKQQNGGVLPPDHIESVAKKVFDNNSITPGTPFMDILAVSLRYWCQYKLNTDPAWAKMKVLISDATVPGEGEHKIMSFIRSQRASPEYDPNTRHVIYGLDADLIMLGLATHEPHFRVLREDVFFQEGRARTCQLCGQKGHEARNCRGEAKEKADDVDDKPGNVTLKPFIWLHVSVLREYLAAELAVPGLPFRFDLERAIDDWVFMCCFVGNDFLPHLPALEIREHGIDTLTTIWRNNLPTMGGYVTKDGHIDLERAQRILDGLAKQEDEIFKRRKEQEDRREANAKRRKLQQNNNSYRGSRGSLAEDRKYGHHDPSQGLPLYPISSYPKEPPRAITHDMVVNKSSAQAANVANKSAASIIKDQIREANRHGSVTTEPEASSSILGKRKAESQSDTETANTNTEVGTVQASKAEHPASAEDHVDTVRLWEDGYADRYYQQKFHRSPDDISFRHEVARAYVEGLAWVLLYYFQGCPSWEWYYPYHYAPFAADFKDLANMDIVFEKGRVSKPFEQLMSVLPAASRHALPEVFHPLMTDEDSEIIDFYPEDFEVDLNGKKMAWQGVALLPFIDMPRLLAAVQTKYPLLSSAEAARNATGRDVLLLSDNNGSMYDDILTKFYSKRQECSKFKLNPKNSDGLSGKVEKRDDYVPHGALQYPLARGAMPNLDYDKSVSVYYDMPQTYQTHKSMLLRGANLPPPALTPSDVEVIRGPMAPTASWWPRLWDRSSAAAAASIWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAA2</accession>
    <name>A0A7D5ZAA2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TVP23</name>
        <name evidence="9" type="ORF">G6M90_00g102190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546127.1">
        <property type="nucleotide sequence ID" value="XM_014690641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAA2"/>
    <dbReference type="GeneID" id="26240550"/>
    <dbReference type="KEGG" id="mbrn:26240550"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="198" mass="22476" checksum="B15584D69F9BA5B2" modified="2021-02-10" version="1">MDVERQQQQQQPLPGTLSWRLSSHPITLLTFLTFRISSVLVYFFGLWVTASMIMIFIITILLLAADFYYLKNIAGRRLVGLRWWNEVDPQTGESKWVFESSEPGTKVVNATDSRFFWLSLYVQPLLWILLAVLAIVRLQFLWLPLVIIALVLTIMNTLAFSRCDKFSQASNLAGSALGTTNLAGSIATNLAGRWFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBU6</accession>
    <name>A0A7D5ZBU6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gatA_2</name>
        <name evidence="12" type="ORF">G6M90_00g087170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542401.1">
        <property type="nucleotide sequence ID" value="XM_014686915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBU6"/>
    <dbReference type="GeneID" id="26244915"/>
    <dbReference type="KEGG" id="mbrn:26244915"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="503" mass="55711" checksum="A3E505FF9764D53E" modified="2021-02-10" version="1">MSALRAAGASRPGMVQTLRAAMTKRSFNTAGAMRMGAAKSFHKDEPAAPILKTSIPGPKAAEAVKELDEVFETRSINMMTDYTQSVGNYIADPDGNMLLDVYAQIASIPVGYNNPELRKVAQTPEMVDAIINRPALGNFPSHTWANILKTGILKVAPKGLNNVYTAMAGSDANEIAYKAAFMYKRQVERGGPEVDFTPQEIESAMKNQAPGSAQLSILSFKTSFHGRLFGCLSTTRSKAIHKLDIPAFDWPQATFPQLKYPLDQHAEENARAEQASLEEVEHLIKTWHLPPAAVVIEPIQSEGGDNHASPEFFQKLRALTRKHNVLLIVDEVQTGVGATGKFWAHEHWNLQDPPDMVTFSKKAQTAGYYYRSKDLRPNKPYRQFNTWMGDPSKALLFRGIISEIERLDLVNHTAKVGNYLYGKLEGLASKYPDQFQNLRGKGQGTFIAFDNPKRDEFLVKAKSFGINIGGSGANAVRLRPMLTFQEHHADILIEALEKIVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBY3</accession>
    <name>A0A7D5ZBY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">G6M90_00g090980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541752.1">
        <property type="nucleotide sequence ID" value="XM_014686266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBY3"/>
    <dbReference type="GeneID" id="26245615"/>
    <dbReference type="KEGG" id="mbrn:26245615"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="171" mass="18842" checksum="737B028FFF03E26B" modified="2021-02-10" version="1">MSQLPGSSDASSSRQHAPAPLSPSERKLKQLGLLFAGAGFMAASVAVTRRAVLRRQLESYPRFYSSNRASLHIDPGERSFMALQALGLATLNVTSFGIMMMGGLAYSFDLCNIGELRERTQAALRRPGNFSPEDEKEMEKMMGSILEKLGMQKPEEAHKTESEDKKTESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC36</accession>
    <name>A0A7D5ZC36_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Pka-C3</name>
        <name evidence="12" type="ORF">G6M90_00g091410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541789.1">
        <property type="nucleotide sequence ID" value="XM_014686303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC36"/>
    <dbReference type="GeneID" id="26245257"/>
    <dbReference type="KEGG" id="mbrn:26245257"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="64"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="342"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="399" mass="44958" checksum="08E4D380E0EBFF98" modified="2021-02-10" version="1">MAATVAQSQAPANLPSNSLTSPAAPGSHAAHEDHSFHNCQAHSKIQAGQAEPLPQIHRFEPSNFNVVRTLGTGTFARVCLVRPSNAPNIPLERDTTGAAQVYALKILRKTQVIKLKQVDHVRHERAILADVAGHPFITNLLASFSDHDSLYMLLDYVPGGELFSYLRKFRRFDEATAQFYAAEIVLVLEYLHEQQGGVAYRDLKPENLLLDKDGHIKLVDFGFAKRLGYKGDHPVETYTLCGTPEYLAPEVIHNKGHTTAVDWWALGILIYEFLTGYPPFWHQNPIEIYKQIVEKPVTFPHDPPISDEAKDIICSFCTIDRSRRLGNISGGAARVKAHPFFRNVNWDDLLGRRQLGPIIPPIRYAGDSQCFDVYPEDDGRRDRYTEEMAQQYDGYFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPR3</accession>
    <name>A0A7D5UPR3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RABGGTB</name>
        <name evidence="10" type="ORF">G6M90_00g011930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549329.1">
        <property type="nucleotide sequence ID" value="XM_014693843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPR3"/>
    <dbReference type="GeneID" id="26238773"/>
    <dbReference type="KEGG" id="mbrn:26238773"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="13"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="35879" checksum="8A2D8C411D548CFA" modified="2021-02-10" version="1">MVHEGTTTESLALAVQAHVKYVQSLDTKKDELDYWLTEHLRLNGVYWGLVALHLLGQPDALPRQETIDFVFSCQHENGGFGAAPGHDAHMLSTVSAVQILAMVDALDDLDARGHGKAKVEKYIADLQDSNTGSFYGDEWGEEDTRFLYGALNALSLLGALSRINLDKAVSHIQSCANFDGGYGAKPGAESHSGQILTCLAALSIANRLDVVDEEKLGSWLSERQTPSGGFNGRPEKKEDVCYSWWVLASLAILKRTHWIDRDALITFILSSQDSENGGLSDRPGDMVDVWHTCFGLAGLSLLQYPGMVPVNPVYCMPEAIVAKCVGSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPS3</accession>
    <name>A0A7D5UPS3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pheromone a factor receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STE3</name>
        <name evidence="11" type="ORF">G6M90_00g014750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985635.1">
        <property type="nucleotide sequence ID" value="XM_066129760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPS3"/>
    <dbReference type="GeneID" id="26238492"/>
    <dbReference type="KEGG" id="mbrn:26238492"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="45596" checksum="E3713B0E281A4E62" modified="2021-02-10" version="1">METSPLHLLQARGPVTVVASAPTFPPYTSPGLTANLVCRVLLAVVANLVCLVPLRLLYRNGELAAVVFILNTQIKNLETIINALIWRNDDIMSWWAGYGWCDFDAYIHNISIGLFVTCLLAIMRNLAQQVGLMRANALTTRERRRRNLIQALIIFPFPILQLALTWPLTAQRYLVGTLMGCNWIPHPSWPFLIFFVLPPPIFALITTGYAGKCRAECLVKTWADIYTLFSSPFLVLIYKRFRQVHKTTETALCGNRIAQQRSQRTRRKLYLMVISILVPFLPIVIALSVLNIMDMHGIKPYSYDQVHNHASPFPWNTIIFFPSSEISWTYMNNCYIPIATAIPIFVFFGLTKDAINDYRQVLLFFGFGAIFPGLHNEYDPDRTVTTSGGSFGSGRLQQTLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPV5</accession>
    <name>A0A7D5UPV5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Smpd1_0</name>
        <name evidence="9" type="ORF">G6M90_00g009700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549544.2">
        <property type="nucleotide sequence ID" value="XM_014694058.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPV5"/>
    <dbReference type="GeneID" id="26238988"/>
    <dbReference type="KEGG" id="mbrn:26238988"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029018451" description="Sphingomyelin phosphodiesterase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="185"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="559"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="644" mass="72825" checksum="C94198AEBF6D5A4F" modified="2021-02-10" version="1">MRLLTILSALAACNLGLRAAELDHEKLQRSLEARTWARETRDLTSLAGQLKTCNGCKRVLSVLKALVKTGDAALVILGKKLCKINSSYDEEFCTGVVEREAPSIASIIRTMKVGSDSCIHFCMSFLGVCDAPKIDEWNIGFTTQKCCHGAKDKILKDEDRDIIQIVHFSDIHVDPLYEKGSNTKCGKPTCCRSYTENDKPGKTRNPAGPFGDHACDSPIALEKSMYEFIKREFPQAAFSLFTGDIVDHGLWNTSKSYNEDLIQHSYEMMTENLNIVYGTTGNHEVHPPNIFEPVSRGNETQWVYDSLSRAWSRWIGNSSMVEARAVGAYSTRYPKGNLRIISLNTNMYYRLNFILYQEVLEKDPNGQFEWLIKELDAAEVIGENVYIIGHMPMGDADALPNGSNYFDQIVNRYSKTIKAMFFGHTHLDHFEISYSNYTERTHNNAVAISYICPSLTPTAGMPSFRVYDVDAETFEVIDAKTYIADMDDESFQTSGPTWKQYYSAKEAYSEIVEPRLTEPKAELSPAFWHNVTVAFENNQTAFDLYMTRKSRGWQADKQCTEMCRQTEVCALRAGRAQDNCWVPTAGVHFSKRDESAHNHNKHDECGSSVTKSLLSSLMRREDMLELLQESFLDVDATIEPALVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ41</accession>
    <name>A0A7D5UQ41_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g004200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ41"/>
    <dbReference type="GeneID" id="26245103"/>
    <dbReference type="KEGG" id="mbrn:26245103"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="49"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
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        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="669" mass="74355" checksum="C4EEAB1A7276D76B" modified="2021-02-10" version="1">MSSPPPLPPRTPSRLSPYPLDNPPLHTSDPRTSSTQSLVPSEASLSKRRLLIVYIHGFYGNDQSFRSFPAHVHALLKELLAETHVIHSKIYPRYKTYKAIEVARDNFSAWLEPHEGDGTDVVLVGHSMGGLLAGEVVLMPNTSPYKTQPFKHRILGTIAMDSPFLGLHPGIVVSGIASLFQPSPNQGDLQEQQQQPGQEKLSASPDSEPCSSSERLPSIDSRIDPMDTGASPRPQRQPTDPHFDPPYYNDAPFLEKPLVKRLIHFTAKHKREGLLNAVGRHITSHLEFGGCLADYRGLHVRYNRLRALEDVDEIEKIAQGHPTGAYARVRFVNYYTLSPGRPKPVKAENEQSQEIRAERNSVDLQLAELDIQDISASKSPGPQIPNTPEKEGEETIQLGANPGPQIEDTVETSTIQDAQNQGEEQHETPAEDTLELTSDNACRISMQDIDPIPFFEAETKECQSQTVTANTNTTDDLDLPPIPDLPRKPTFPDIDANLDKDAKKQAERESKRLQKAYAQAVKDRAKAVQEREKVLERRRKKAAKEAEKQAKDAEKTRAKLEKQVEKRRAREEKQASESVAAEGHGEQDGTEDAERPKKLKKFCALPSKRDGARDPTWVDVYMDGLDEVGAHCGLFFPGPHYDGLVGDVGSRIAAWVGDELTKRAIFEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ97</accession>
    <name>A0A7D5UQ97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANK2_0</name>
        <name evidence="4" type="ORF">G6M90_00g002510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542830.1">
        <property type="nucleotide sequence ID" value="XM_014687344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ97"/>
    <dbReference type="GeneID" id="26244203"/>
    <dbReference type="KEGG" id="mbrn:26244203"/>
    <dbReference type="OrthoDB" id="4936597at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="371" mass="40513" checksum="6C9CCC4B59CCFAFD" modified="2021-02-10" version="1">MKLLLEERCKQSGNFDINARNSSGETPLHLATEAGQSLSVQLLLEHDANVDAITANGERAFHIAASLGHVQVMEKLLAARTEDYHLCDENKDQLNVLFVAVQKGHTRIVEMLLGVPIHPKKLRGVRESPLAMAAENLKKGRDMLRLFHERGWNINWRPEASIACTALHAAASVGNAPVVEYLLEKGAEHDVQDFMGRQPLHLALEGGDADVVKMLLSQGADIDARDEQNVSPLLLIANRKDTKMLEMVLERHPGVDIGSKQLPTKRTVLQECCFNPEATKLLLERGANATTRSDSNVVHAGFQPDCTGDDGGSILIAAAFYGQLATVQLLVERGANVNAADKKGTAAIHHAAMRDTPEMVEYLLRQGANLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR14</accession>
    <name>A0A7D5UR14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of nonsense transcripts 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">upf1</name>
        <name evidence="8" type="ORF">G6M90_00g017030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548828.2">
        <property type="nucleotide sequence ID" value="XM_014693342.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR14"/>
    <dbReference type="GeneID" id="26238272"/>
    <dbReference type="KEGG" id="mbrn:26238272"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="466"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="649" mass="72236" checksum="11993520E625ED0E" modified="2021-02-10" version="1">MKKMLDNAKLLMSVQRDLFLGTGFYNTFEGKPTSASGKITTAISNLLLSDALGIPYTPFNPLPNIPLLRITDRDFVDSLMQEALPEDRSRFTEYLCNRPLGLGIITAPPGFGKTTALAIGAVAMAQTLGKLYLSGPTHISVDNAAARLDLISDRVTNRLNDKLSQQGLSPKYHRKLIIRAFKIDDELKALKNALQNPQDASNATIESSWSRNSKWRLHLSLAYWVLVVIRSPAVRQLGPHDKESLHAIREKCDKDGSLAVLGKVAMGIIEWEKYKRRGLEVIDGRDSPVRRLMTSILSVADVIATTPYLACKKPFCDWRKREARGFIFDEAANMNRPDLLCVWGNTCKPCLLAGDEKQLPPTVMTKQERDEDGNSLNRFAGDGAISPIHHFKSMGWPIYRLRVLLRMAEGQFDLTYNEVYRDIPFTYGPGCAIDLPHHEIGRKLESYLCRKFPRIKPAPAGELLPVFVHCEGSQSSQDEFSGSTRNPDQVTLGLKILVNFIKSSGARPQNMVIISPYLANVGTIEKFRKRPEFAALKPMRPTATVDSFQGQESDIVMIIMGTTASSGPGFTSDEHRLNVLLSRHRSGLIIVGDINVTGDVLKPEAPFQGVMVIGRTGEKYFEPCRMLRNVHLALQGAGRVARIRLPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR43</accession>
    <name>A0A7D5UR43_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor gef2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gef2</name>
        <name evidence="4" type="ORF">G6M90_00g016270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548901.1">
        <property type="nucleotide sequence ID" value="XM_014693415.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238345"/>
    <dbReference type="KEGG" id="mbrn:26238345"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF21">
        <property type="entry name" value="GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="248"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1469"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1257"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1279"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1508" mass="167758" checksum="EE889519B186130D" modified="2021-02-10" version="1">MVRVTDDLALSPDALSLYYASDPLLGHLPVLIFHGPSTTANYTLNTSRVQIHILSSAGFQSFPRITISPSSPFYGVVDHLPREIQVDEVFRGLAFGLFKYFSELPDGVKGYLKNLYPTRGKRPGTASALFGEQHAAALVASMVKSDNAAEVIASLQDALQTQHINNVDLDFVLPPGAIVPLQPADLEDVPDDEDDILDPTLRQYGGYTSLVKLFGEPVFLPTNRLRRAPSKPTSLNRGRLFTQDQKYELRMKLAELVDTEERYVMKLRELVNTIAKDFRESARARPEGSLSPSEEELERLFPQSADQILQLNSAFVDQLRKIMDETEDGALRDMDQAASTLGSMKSSGSARAKDPSGALSMARLFHEWFPKFTQSYQDYIKASQHFPILLNSFLDQQSSFRQRVNQTGEQTVRSILIEPVQRLPRYSLLIDQIVGSLPMTHPALQPMLKARDIITSICSMDDPLPDQPHVANRLRNMVESWPRDLEPHGRLIVAADFIELMPPFQGGTSDLDSSGIFLLFADCIIILRKIGFTMTGRDLLREIDKPSAAELLISMTNAAGGPASYEFAFTGWHSLADVRFTESEDGSLVWMTSTRDMKDAHTGEYKISKAPTSRCFLLQEAFEGKATKWGEDVVKARVEARFSETERENPCWTLRSVRMQDNNLGLHVAVFQEGAHQLVEGRREPAAIRVVVDHEKGTKGAPPGHYGVEIVINVSSNNLKRVSMLTAGLNGKQFEDDIDLEDLLPTMSRRIIQLLSTQFNVSNTHLTASMVSYYTKTIRGLNFSTRTEKGRSFLAASPVKLLSSLWNGSASNSPDVVVSGVKSQQQPSLHRANSIHSMFGSIKGKDSRPDTADGRPANPLLRLEQTFTGFTAALQSRKGTIIGRTLLNRSLVDELSVNDIYNRFIETPFEYDVASDIGTEVVFVAFEKFLHIAWADQMGPVMTMQAMDTLLERANKRVPGNFADFVNYLFRDMAPQNRRAFITVIKLLADLLDGCGNDSDRGALTLAFAELLVTDGEAHNYINLLDRLVEDCDKISEDQSAHQSFILGSFVSESLVSGYRQGKAHTGSITSNASSLRRKFGLNALLRQNSQDERPSVWRTLSKHRNPATGDTSSLSRGAHGKLYRAHSIDDNSLPKQLHRRGMSRDRPPIAGAFDETPQRPTSSRRYDFPLDTIGEPSPTERIVSNTKNPKKKRRSSLSDLKSLMAAATLDEQPFQPLQSTKQTSGKMNNNPISPKSAPLSKIPVSPSAAEALRASRQKEKENLADSSKKIVSHVSEHSGGNSSKSPETPSRIYRHSKALSVSSIPTLRPSKLASGADYPTRPVSPTRSNAQRLRLHSPQKLRERLQSEKQFAQEVDSSLKSELSKIGDEMARVNKARSPNSQTDMSGFTASLKELEDRIGVMMRELREQQATTQKELDTTMKSTEAKVRAIDQLHKEVVAENELLYEKFNGELGKIIKAVRGKGRDDKEELVAKLKEQGEETARAKKENARLKREMVSLKTMLRGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URL8</accession>
    <name>A0A7D5URL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g026140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547968.1">
        <property type="nucleotide sequence ID" value="XM_014692482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URL8"/>
    <dbReference type="GeneID" id="26237412"/>
    <dbReference type="KEGG" id="mbrn:26237412"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="493"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="676" mass="73892" checksum="89B8A12B38B2B39C" modified="2021-02-10" version="1">MKNLSQIKDGVAASFRTDPTINRVRGWAGPASRRLPSATAEYLAEKLPVAQWLPHYDPRWILRDLIAGVTVGVMLIPQGLAYAKIATVPIANGLYASWFPPLLYFFLGTSRELSAGPTSILGLLTAEAVEDLSRQGYRPADISAAMAFMVGVYALAVGLLKLGFLLDFVSAPVLTGWISAVAIVIGLGQVGSLVGLDLPPNVPGIIHDFFAHIRGVKPLTLAIGLTGLAFLLVLEQVGKRNKRGKYVKFVCTSRAVILLIVYTLISYLCNRGRGNDLLWAVTKVDTHGLPAPRPHDPALLKKVAVRAFAPLIAMSVEHLGVGKAFGLRGDYSIDKSQELVFLGVNNMVNSLFGAQATGGAMSRTAVNSDCNVHSPVNFLFTGGLIVLTLYELAPALYWIPKATLSAIIIMAVAHLVARPSQFYRFWKMSFVDFVGSQLALWVTLFTSTEIGLAVAVGFSIVYTLLRLAFPRWIGLSHLETENNHVSLPCAGAASTSVDVPAEAYLVQYTDDILFPNAERVKASIIQSIKVHFDPASDANMVVDKSRRTWNPATKKQIIKIRKRKGITAFSGDETPLRRVVLDFGRVSFIDTTGVFSIIELKMELRRYIGQDLEFRFVGMVDAVKERFDRSGWEFASPGRQRAEAADVVYSSIDMALWHPGKSDDKDDLSKEKALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URS9</accession>
    <name>A0A7D5URS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g027350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547852.1">
        <property type="nucleotide sequence ID" value="XM_014692366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URS9"/>
    <dbReference type="GeneID" id="26237296"/>
    <dbReference type="KEGG" id="mbrn:26237296"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="592" mass="66398" checksum="0922F1D9F43A78BF" modified="2021-02-10" version="1">MADAGLVQASLIWTTYAIAVVLCFLAAIITTFTWQTPRDRSAVVSIVAIITLTSLLATVLLLPVDIALVSATNSVSQGAKKDWATPERVNSILLTLKIVYYCLYSADALLCLVVIPFAYFWYEEYDEIEFEEQGRTWHSRFWAACKYTLFFVALVVVLFLLGFFMPSPGDSSKAHWDLDYFKDLIARNHAEKALTFALGLLITLGTLLYVVYTGSGLAMMPIAFIKSAPSMSAPQLSATTASQLEQNRERQRQLEMRNSGRQDGMSRKDRRELDALIREEQTLVRRERLAAEAQGEGKSRVYQAWLRLCALLRPLKMLCGILLLATSLLIWVSMLITGIDKAKNSVCKQRCGYILGNIHIFQPLNWVFVKLARVFPIDYVLMALLILFLFSSTISGIATVGIRFLWIRIFQIRRGRTAPQALLIATVMLTLAVLAINYAVGMFMAPQYSIYGTQTFCSNKPEYPGAQPSCKGQPDLVRPCSEQLDFKHAKDICTPSVMSTFLNRITMTWPFFGIVDFWAQFAFLAVFLIVFATAIVRSPRVNIAELDEDAEDAEEEGLLAATGRRLNATWEDVRRSPAYGSTRNGRSDNSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URU3</accession>
    <name>A0A7D5URU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g002810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985924.1">
        <property type="nucleotide sequence ID" value="XM_066129538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URU3"/>
    <dbReference type="GeneID" id="26244175"/>
    <dbReference type="KEGG" id="mbrn:26244175"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="203"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="53192" checksum="CEBF8A094A81FFE4" modified="2021-02-10" version="1">MASNGSFNMAPGHLGNLTADQEAVLRKLWQTVFMLYNMFEHAGPIVSDAGSINTESPRRTGFFGRTSQEVPPTPKPSPDVMEALQIITTDPQEQQRLLKQFSQLLALQSPESIKHFKDGLAAAPPESIQQLRAVLADQSPETIRDFQKLLHGQSAQSIRSMVIGAVKHEHPDTLILRFLRARKWDINKALMMMFKAMNWRHVDFKIDEDIMPNGEAGAVADEKAAKTLGRDFMKQIRMGKSFLHGTDRHESIERYTTYLIETARFVLNPPVETACLIFDLSGFSLANMDYVPVKFIIMCFEANYPESLGVVLIHNAPWLFKGIWRIIHGWLDPVIAAKVHFTYGRKDLEEFIAPEQLIKELGGDEDWAYEYKEPVEGENDIMKDTATRDGLLQEREDIAIRFEDATKDWVLHGDGPKGQEYKAKRDLVAREIRDNYWKLDKYVRARSLYDRLGYIRGGAEVKWYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URZ7</accession>
    <name>A0A7D5URZ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g006990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549811.1">
        <property type="nucleotide sequence ID" value="XM_014694325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URZ7"/>
    <dbReference type="GeneID" id="26239255"/>
    <dbReference type="KEGG" id="mbrn:26239255"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="29233" checksum="87945B0E642A6BD1" modified="2021-02-10" version="1">MTGKNTVPAAPWRAAFLSHIEQVQQPTFTLSSLHPASPPSSSSSCPPQFVPRARTVVYRGMWASLTPNPKNPAQLNPASYETDLPTITTDARMEKVSEIFSASNGGDSSGIGGAVEAVFWFPDSMTQWRLRGHACLLGPDIDSLEASSTREALAPYMRKAGDAEWSWSRELTAQFGNLSPFMRGTFRNPPPGTPITQVPGEGLGLGQVVEDLEDEVARKNFRVLVIVPEEVDRVDLSNPERGQRWNYTLELRGHGAEWRETELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US58</accession>
    <name>A0A7D5US58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g017380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548792.1">
        <property type="nucleotide sequence ID" value="XM_014693306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US58"/>
    <dbReference type="GeneID" id="26238236"/>
    <dbReference type="KEGG" id="mbrn:26238236"/>
    <dbReference type="OrthoDB" id="4114825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF1">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="156"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="805" mass="89999" checksum="D572E1E02A2399C2" modified="2021-02-10" version="1">MSSADHVLQQDRELWISNGNCLVYLHGSEATKDKDATKAPVFKLPFSFLLMTRCYPLIQRFLVINNPSERGVRTPRTPGEINKWHRSNPKRTVELFIPAPLNADKKKVERHQLLMRNFFAWVLRRPLVGETLGEAMIGLLNCMHEYRSGGKVDNAADIMGYLDEKGYLCLAGQPAHALAVLQLAETFRMKDLYLQALAHCVGMRDMLLCRREFKHTSPATRNLIHESENELKSRFNRASAMLENFLDQELSEAHLGIPLGLRAHLERFRSFLLSFYSVRLGYYPPSSFDAAVYRAMAGDFKALYRLLVDEAYSSSEAMPSVAVGGICTLQLIQSLDMHSHLEPMKHPLPKLPQLDPRPRPRRLAWLPRGPKHRADERQLGHAALLNASNWEEDVLDNSLVRAYRQFEEDCALERKRRDRRERVSLVDGRKVRWILIYAVHQTLRYATQRPHGVQDDPSARYLVTIAKDTLPPWQDKNTRGGLIRSQTEPALNRLGRLHDADLATAMERFEIKPDIDYFALTHKQDAPPPPRSRRASLPPLATDNPSALSRASSFKQVLNRSSTIRKSVRRLTQSAAPPSLPPSPVTAGKPLYHEIVVHGYGNGTNDVRLGSRAGPPLPSSDVGRSASTASETASSNASTVPSSASMVDTAESSLGSPVPPDSPIEILLPKTRRWSTHDAAVPYGNNSPPVSKSNSLRRRPISSAFEGYTHAAKAFGHFVDNERRSIFANSRQSGADPKRSSSIAHSRSIALPIREDDIAEETCLLPRDSGDWTAMQAFLDGKGVDTDAGHAWEQYADLGGLTEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US83</accession>
    <name>A0A7D5US83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aspartic protease PEP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PEP3</name>
        <name evidence="14" type="ORF">G6M90_00g010660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549453.1">
        <property type="nucleotide sequence ID" value="XM_014693967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US83"/>
    <dbReference type="GeneID" id="26238897"/>
    <dbReference type="KEGG" id="mbrn:26238897"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028933476" evidence="12">
        <location>
            <begin position="22"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="239"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="103"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="551" mass="58211" checksum="9792D2538730CABC" modified="2021-02-10" version="1">MHAQSLVVYICALFAFVSVSAADIQKRSFSVSRVANPNFTGRNGPRALAKVYRKFLVPLPKGLEETMHAQDKRQVAAAQARKRSPEAFRPMRLRQPGRRGLLDDLLQGLGLEDGNQNGNKGEQNGNQGENGNKNGNKNGNQEGNQNGNKNGNQNGNQEGNQNGNQNGNQEGNQNGNQNGNQEGNQNGNQNGNQNGNQNENGNNNGNKNGTTGAPPQGTAPGTNQTGTVEAKPEANDAEFISPVKIGGQTVNLDFDTGSSDLWVFNTQLGTGSGAGHRVFDPQRSQTFRLMPGASFNISYGDGSGAVGNVGTDVVDVGGASFPNQTVQLATAVSQSFVQDQSNDGLMGLAFSKINTVKPVKQATFFDNVKDSLAAPVFTADLRKAASGSYTFGTIDESKFKGPMAWIPVNTTQGFWQFTSERFAVNGGQPKTSTPGGQAIADTGTSLMIADSVMVQAYYDQVQGARVNAQDGSVVFPCNAKLPDLDVDIGGVYMARVAGSDMVFADLGNGECFGGLQVSPIRNLAIYGDIFFKSQFVAFNAGNTSLGMAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US84</accession>
    <name>A0A7D5US84_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g014890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549035.1">
        <property type="nucleotide sequence ID" value="XM_014693549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US84"/>
    <dbReference type="GeneID" id="26238479"/>
    <dbReference type="KEGG" id="mbrn:26238479"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="559" mass="61234" checksum="B699267F6EA2D476" modified="2021-02-10" version="1">MATRARLLRGVGNGRCSHVSSLVAPAASRGLPKATARLASACRSSVLPPTRCLGSRSFSGTSASRAAKLTTDSYPGLTRDSRFSQLTPEHVAYFKQLIGQDSAVIDGINADAAADIEPFNEDWMHKYKGQCRLVLKPGSTEEVSKILRYCNEKMLAVVPQGGNTGLVGGSIPVFDEIVISMGRMNTIHSFDEMSGSLVLDAGCILEVADQHVAERGYIFPLDLGAKGSCHVGGNVSTNAGGLRLLRYGSLHGSVLGMEAVLPDGTVMNDMCTLRKNNTGYDLKQLFIGAEGTLGIITKLVVQCAQRSPAVNVALFGIESYEKAQRAFREAKLQLSEILSAFELMDGTSQRLVHQVRGGTRPLENDYPFYCLIETSGSNSEHDYEKLEKFLEDVMSNEVIADGVVAQDATQIKTLWSWREGITECIGHWGGTYKYDVSIPLSEMYLIVHDVKARLSEAGLLGETDDHPVVDVLGYGHMGDSNLHLNIAVRRYDKEVEKVLEPYVYEWIEKRQGSISAEHGLGLAKKNYIGYSRNETMIGLMKQIKTLYDPNGIMNPYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US86</accession>
    <name>A0A7D5US86_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g027050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547881.1">
        <property type="nucleotide sequence ID" value="XM_014692395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US86"/>
    <dbReference type="GeneID" id="26237325"/>
    <dbReference type="KEGG" id="mbrn:26237325"/>
    <dbReference type="OrthoDB" id="10283378at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="107" mass="12034" checksum="8005B80CBE3F86D6" modified="2021-02-10" version="1">MTDVDDKPGEKPRFSFQAFNFGQVAGSARLLFGENPKELDYVCVMGRCMPAGYDKLSELWVFPKQVTGMFDNRVDVYSLSGLGTIELDMSKQGNEDPLFSFYVKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USH3</accession>
    <name>A0A7D5USH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Long-chain-alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FAO2</name>
        <name evidence="9" type="ORF">G6M90_00g013170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986051.1">
        <property type="nucleotide sequence ID" value="XM_066129742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USH3"/>
    <dbReference type="GeneID" id="26238649"/>
    <dbReference type="KEGG" id="mbrn:26238649"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="270"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="577"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="746" mass="80999" checksum="4768E627C55C2185" modified="2021-02-10" version="1">MDAIDIGAPTPTPLPDPPVKDFMTDAQWETLYALLDGVLPCITSTTSSDVKDKNSGILLSDTDFEALIDDCTAALSNPPSRHKIKEYLEFRPSQDENFRDDCLRSLAIVPQRNQLIKILNLLGGHAGSMLLTGYWTPITQQPTKVREAILKSWATSRLTPLRMLAKALAQMAQKANAIHSPYFREISGYSDAPKDWKPVEGYEYNFIRVPAGTGVHEITTDVVIVGSGCGGAVSAKNIAEAGHKVLVVDKGYHFPPSQLPMTQASGSHHLFDAGGVFFSDSSSMGVACGGCWGGGGTVNWSVCFRLQDFVREEWAAAGLPLFTSSDFDDSMDRVWDFIGASKDAIRQNPRNQALLDGTQKLGWKGGVVEQNTGGKEHYCGQCHLGCGSAEKRGPTVAWLPAAGDAGAEFMEGFAVDRVVFAEDGVTAVGVEGTWTARDENGGVHTPQNTRTQRRVVVKAKKVIISGGSMWSPLILTKSGIKNPNVGKHLHLHPVNLVSAIFGKKDLASWEGGIITSYVDEFENLDGKGHGVKLEPVVNVPYATYSLQTWRDGIDAKLLALKYRHIGTFIVLTRDRDTGRVYPDPRKGTPRIQYDTSDFDREHTIEGIIALAKICYVTGATEIRPHLHHLEPFVASDGGKRQAEHQAGKDPEFTDPEFAAWIKKLRVADNQGPTAMWMSAHQMGSCRMSADEDTGVVDMKGKVWGANNLYVADASVFPSASGVNPMVTAMALADWISRGVASELAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USM0</accession>
    <name>A0A7D5USM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin assembly factor 1 subunit rlf2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g003270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985991.1">
        <property type="nucleotide sequence ID" value="XM_066129546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USM0"/>
    <dbReference type="GeneID" id="26245016"/>
    <dbReference type="KEGG" id="mbrn:26245016"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="361"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="558"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="69948" checksum="02487D41A6284F72" modified="2021-02-10" version="1">MSPNVQETKASGRKRCHGEFAADMMKVDDGGDAKTPQPTAIRRSGDSLLPLRAQIEPHSSPGGSSPLTEEGSRTPTRDSPSPTTQTDTTLDSNSCDQKNLDTMVTSSKGAASKRKRLTAEEKVAKEKEQAEKKKEREEQAAKRAAEKARQEEEKAARVKEREEKRKQKEEEDRLKAEQRDEKKRKKEEEQRRIQEEKDKKARSQPKLNAFFKIPDTPKKSANGSNSAVGSPIMTNGGDAPAKPMETEYERLFKPFFMRENTRLAPSATQMDEETREAKSRILDKFVASQRDTDNQELPRFDPVEALRLPARTPRRGRIHHPVKHIMETAYRDADNSNIVGASGATSIFPEARQKLASIPQKVIAFSHDVRPPYYGTITLKSYALGRDAMVKLARKPTGRRLPLDYDYDSEAEWQEEEGEDVDMDDDEEELDDEDDMDGFLDDADDAGLSRRVFGNTMEPECTGVCYENYHRLGPNRTVYEHKMEFIHEGLEQTWGIDPFSSQYWEPEVKAQPAKVSQSAPESTTEMPPPPAPTNAFAALHGGAANVSAPTKLVKAELLNDFKRAILDNKALSKVGIIDFIFHQFRNSVSRAEVKNTLEHVAEKKGAGRSKEWDLKPGHEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USU5</accession>
    <name>A0A7D5USU5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">usb1</name>
        <name evidence="5" type="synonym">USB1</name>
        <name evidence="7" type="ORF">G6M90_00g027180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547869.1">
        <property type="nucleotide sequence ID" value="XM_014692383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USU5"/>
    <dbReference type="GeneID" id="26237313"/>
    <dbReference type="KEGG" id="mbrn:26237313"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="34014" checksum="D0EEFE02CFF78393" modified="2021-02-10" version="1">MGLVDYSSSSDDEAPAPPKKRLKGQEHVSDSKMPPLPEAFYDLYASTVRQSVVDDPSLHQGRTRLNPHVAGNWPTHLYIEWHPTEVQHETLDALIKKTQQELGDDIQLHSFLNSDLGTDLPLHISLSRPLSLPTSIKDDYLTKVKHSIRSCGTGVFSVKPAGLAWYKSPDSDRTFFVVRIAPTDANDDSKHLRASTHPELMMLLTRCNTVAAHFDQPPLYEQTQGESAATAFHISIGWTLGAPDEETRLRALKLFQDKEFEDIHAWNVKVDGVKAKIGNVVTHIPLLGNVKTKEEDDFADSLYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTC5</accession>
    <name>A0A7D5UTC5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sphingosine N-acyltransferase-like protein FUM18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FUM18</name>
        <name evidence="10" type="ORF">G6M90_00g002450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542835.1">
        <property type="nucleotide sequence ID" value="XM_014687349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTC5"/>
    <dbReference type="GeneID" id="26244208"/>
    <dbReference type="KEGG" id="mbrn:26244208"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="156"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="54630" checksum="7D02EAE3CDD024E2" modified="2021-02-10" version="1">MGDYDRTQSLDAGVADGPSKSQFRPAPSPSGSKVPLYMQSSDGKHVLVRRVRRKEDGSWKHFARWFVENQISLSFNLLALLFLCHNFIPKARAHTRKYFQLAYYNAKTGQYASGFDDAYFITFCIVLFTLLRAGFMEYILAPFARMQGVTKKKDQIRFTEQAWLLVYYSVFWAMGVYIYCKSPYYLNLREMWTDWPNREMDGLMKGYVLAQWAFWLQQIIVLNIEERRKDHWQMFSHHIITTVLISSCYFYHHTRVGNVILVIMDVVDLFLPAAKCLKYAGYTTLCDIMFGVFMLSWLMARHFVYVMVCWSVYAHTPEIMPSGCFRGSNDHLIGPEDPPAGLSWLIEPFLSSTGRVCYNETVKWSFLTPLLALQGITIFWFTMIVRVAMKVLRGDGAEDSRSDDEAVEDEDEYVYEEAEPLEEEVDADEIDLRSWERRTGVKRQASSSGVSLPGHSDRKELLGRIGCEKQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTN6</accession>
    <name>A0A7D5UTN6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Dicer-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DCL-2</name>
        <name evidence="22" type="ORF">G6M90_00g008960</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986112.1">
        <property type="nucleotide sequence ID" value="XM_066129658.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239059"/>
    <dbReference type="KEGG" id="mbrn:26239059"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000032">
        <property type="entry name" value="Dicer-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="100"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="437"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="21">
        <location>
            <begin position="628"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="18">
        <location>
            <begin position="981"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="18">
        <location>
            <begin position="1164"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="17">
        <location>
            <begin position="1374"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QLI66213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1451" mass="162950" checksum="49D48EC656FAAF49" modified="2021-02-10" version="1">MPGGYHHRNMIPATSPVGSYSSNESEVPGILPETVWVEGDQNDTPTDFPNIRETISADALQASPQEQHEDASHQGIACDNETSGTPSATAMSPRAYQLEMLDQSLKQNAIVVMDTGSGKTQVAVLRIKAELDRSAPDKIIWFLAPTVALCGQQFDVIRLQAASVAMKLLTGNDQVDTWSADTWDTILDGVRVVVSTYQVLLDALCHAFISIDRLSLIIFDEGKHPGSKIMTDFYHHNKHAAKSIPNILGITATPSMKEDLANMEILEAVLDAKCISPTRHREELLKCVKRPQIYSIVYDAPRSLQYTESMYRLRKEFLNLDITKDPYILRLQEDPSDRNRRALVRAVEKYDTFVQNQIKGLWGRSAEILQQLGTWAADMYIWKSSAAFLARINTDAIFNDWVDAEKKYLADFIRRVSPSCPASMPQSGSEVSEKATALVRELVSVEESTVCLIFVKERATAGALREFLVSCPRIVEKHRIGSMVGTSNYQSRKLALYELVGQSSDPMAALQSFRSGKINILIATSVLEEGIDVPACNMVICFDHPQTPKSFLQRRGRARMKESKLILLSEHSSSAVAKWEALEENMKAVYQDTQREIRAIQSLENSEESSSTFMEVESTGARLDFENAKSHLEHFCRVLSQGEFVDSRPDYIIHSHEDCDSSSKPRLSATVLLPSFVPSQLRQIDSKFSWRSEKNATKDAAFQAYQTLYEAGLVNKNLLPFKYEDIPGVETRAPEVEVDALLNPWFGVAKAWTEGDQSWLYSLKCCDHMHGESEYNVLIPAELSQLRNIQLYLNSSDLCELRFDSRRPISAADVAAMPDHTSALLALPFAHRWPIEEKHHIIRVWTQEHHVSMGGIGGKTFDPNSSDVIEGKYLVRNESNSPYHYVGLLPSKPPVESVQSSIFDYENAPADEPYLVVKKWTKRSDFLHPVLSSDATPTTTKPYPRVIPLPWATVDSIPLKFAQFGMLIPSLIHELEVTLIAKELSTTILERINITDLRLVREAISSRSAAEPVNYERLEFLGDSILKYCTAIQVSAIHPEWPEGYLSFFKDRLVSNSRLSRAAIDVGLAKFILTKTFTGQKWRPLYLENYTGNPGKVSPRKLSTKTLADVVEALIGASYVNGGITKALNCISLFVNEIQWQDVSANRALFFKMARDQDKLPAELKPLEHLVGYQFNKKSLLIEAMTHQSCMFDYQRRSYEHLEFIGDAILDFIIVRKMYTAEPLLAPHQMHSLKTAMVNADFLAFLSLDHQMRRTETAVTSNLQIVDKETTPLALWTFMRHSSEAIGIEQATTLKRYEALRGEILATLRQGSHYPWALLAGLQAKKFYSDIFESLLGAVWVDSGSIELCECMLQKFGVLSILDRLLKDRVQVQHPKEVLGKMAVTQTVTYNVDVQEAADGDRAFACRVLVGQRVITEVVDGVTKEEVKTKAAEAAIRIMSAERDKAAEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU00</accession>
    <name>A0A7D5UU00_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Baeyer-Villiger monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BVMO</name>
        <name evidence="9" type="ORF">G6M90_00g033200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986258.1">
        <property type="nucleotide sequence ID" value="XM_066130121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU00"/>
    <dbReference type="GeneID" id="26244050"/>
    <dbReference type="KEGG" id="mbrn:26244050"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="573" mass="64962" checksum="6625EA165B5577F8" modified="2021-02-10" version="1">MGESSPTRPKKFNTELTDYSLPRHQQDGPYADNLDLDVIVIGAGFAGIFMLKTLRDRGFKSVIFEAGSDLGGTWRWNSYPGAGVDSEVPEYEFSWPEVWKTWNWSSNYPDYRDLRAYFDHVDKTIGVKKDCSFNTVVVGASFDTAAGKWSVRTEDGRTAKAKFLVLGTGFAARRYIPDWPGMDKFKGVIHHTSFWPEEDVDVKNERCAVIGTGASGVQVVQAWGPVAGEVKVFQRTPNLALPMRRRKMTPEEQERKRALYPELFTLRETSFSGFYFDWYEKNTFDDTPEGREAVYEKAWRDGGFKFWLGIYKDNLFDGEANKESYRFWAKKVRARIDDARKRDLLAPETMPHYFGIKRPCLENDYYEQFNRPSVDVVDISNNGIKEFTETGITLDDGTHHEFDVIAVATGFDIVSGAMTQLGLQSINGTNLQQEWASGISTYLGISVSGYPNMFHLYGPHGPTLLSNGPTTVEVQGRWIADMLDKIQRQDIKYVNPKREAAREWTRHVVELNDKTLIPTTKSTYMGGNVPGKVYEPMCYAAGVASYRAEIRAALDSMQGFEVVSNRIAVNPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUL8</accession>
    <name>A0A7D5UUL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps-17</name>
        <name evidence="5" type="ORF">G6M90_00g046570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544783.1">
        <property type="nucleotide sequence ID" value="XM_014689297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUL8"/>
    <dbReference type="GeneID" id="26242124"/>
    <dbReference type="KEGG" id="mbrn:26242124"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="146" mass="17031" checksum="8E1E6F6A22B0D09F" modified="2021-02-10" version="1">MGRVRTKTVKKSAKVIIERYYPKLTLDFETNKRICDEIAVIASKRLRNKIAGYTTHLMKRIQRGPVRGISFKLQEEERERKDQYVPEVSALDYTQNESGQLEIDSETKDLLKHLGFDSIPVNVTQVTQNNPNERGPRRFGDRPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUV2</accession>
    <name>A0A7D5UUV2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545174.1">
        <property type="nucleotide sequence ID" value="XM_014689688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUV2"/>
    <dbReference type="GeneID" id="26242515"/>
    <dbReference type="KEGG" id="mbrn:26242515"/>
    <dbReference type="OrthoDB" id="4940373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="88" mass="10014" checksum="4136DA11D1F1D10A" modified="2021-02-10" version="1">MGLIKTLIVSGAAVAVAKEFNKKRQDKKHSNGPQYGQDQFSYGPPPPQRHQGYSQHNYQQYAPQGPPPNYYNQPNANQAPRPEKWSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV67</accession>
    <name>A0A7D5UV67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g048050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986318.1">
        <property type="nucleotide sequence ID" value="XM_066130437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV67"/>
    <dbReference type="GeneID" id="90967736"/>
    <dbReference type="KEGG" id="mbrn:90967736"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028818315" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8214" checksum="C5BCD215FACF8784" modified="2021-02-10" version="1">MLARVLVAYAMGLVGLVGASLNNVADVGDETDAATGRKCGTILGIPCPEGYRCMNPTFCADCEGKCEKIEPEEDECDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV78</accession>
    <name>A0A7D5UV78_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase trt5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trt5_0</name>
        <name evidence="6" type="ORF">G6M90_00g039610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547315.1">
        <property type="nucleotide sequence ID" value="XM_014691829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV78"/>
    <dbReference type="GeneID" id="26239878"/>
    <dbReference type="KEGG" id="mbrn:26239878"/>
    <dbReference type="OrthoDB" id="4935415at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="273" mass="31340" checksum="ECFD378D456D2E67" modified="2021-02-10" version="1">MDIIASQSWAYIPDLPDDIGPIRNLLLVYSRIPASDIDSHILRVREDAWRVSRFPCVGRWKFLRLTEQNDPCYRQVLFRLNVPRSNDAFLDLGCCVGQVLRQLRHDGVQGNQLFGTDVQSKFVEIGYDLFQDQDEFGATFVVGDMLDPDDTRLDDLLHKVTIIYAGSFFHLFNWTQQVYIGKRLVGFLKRGTKNALIYGRHIGTTRPGPSPLGNDMSPYLHDKDSFQRLWDEVGYLTNTKWAVEIEPAGEKIVDVPRIDRDAQPVNFVIHQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVE2</accession>
    <name>A0A7D5UVE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity nicotinic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TNA1_0</name>
        <name evidence="9" type="ORF">G6M90_00g039940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986479.1">
        <property type="nucleotide sequence ID" value="XM_066130263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVE2"/>
    <dbReference type="GeneID" id="26239907"/>
    <dbReference type="KEGG" id="mbrn:26239907"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="73"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="521" mass="57533" checksum="110FEABFE1405864" modified="2021-02-10" version="1">MATEKPNDHAGHIETTMSGYDSQGADRDQGLSSATSEKAAERGEVATNEYGESMILFDPVAERKLRLKIDLYIIPTVAVLYLFCFIDRTNMGNAKIAGLEAELGFTGYNYNEIISIFYISYILFEIPANLLCKYMGPGWFLPLATVLFGIASVATAYVHNFAQMAGVRFLLGVFEAGMLPGCAYYLSRWYRRSELAFRLALYIIMAPLAGAFGGLLASAILNLDSFANLHRWRMIFAIEGIITIGLGLVALFTLTDRPETARWLTPEEKEMATARVKSERVGQTAVLDKIATKKLVRGILSPVTLSTSFIFLLNNITVQSFAFFLPTIVRTIYGSKSTIQQQLLTAPPYLVGAVFMIPFPLLSWRMDRRQIFITLSAPLVMVGYCMFLGSTASSVRYAATFIIAMSTFTNGAMCSAQVSANVVSDTARSSAIGANVMFGNIGGLLSSWAFLPWDAPNYHIGNGLNLAAAGTIFIVALLTHLWMKSDNKKRATRDADEELRGLSQEEIEDLDWKHPAFRWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVK3</accession>
    <name>A0A7D5UVK3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g031220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543061.1">
        <property type="nucleotide sequence ID" value="XM_014687575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVK3"/>
    <dbReference type="GeneID" id="26243862"/>
    <dbReference type="KEGG" id="mbrn:26243862"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26498" checksum="B072C3E4F2566094" modified="2021-02-10" version="1">MGFWSPMTLPLFYDDHHDWDQVHAREDESLGFRIDGNVDAPPSLSHFDELQGTSPLQSSSTASGSAADHVLDDLITSRPPTADPNAVSADFFKDRSHRCECVRVLADILERIDRDDGSDSDQTEHFDDLLVDFRDGIDTSIDVPPPSLSAGIHVGKYTVRATTLTFEFVFTIVTMHFNDLQRLLEHLHDEIKTGTKAFKLLQAAVDDVRRVFGDLQMIAKGRSAANSLEQRKRKAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW87</accession>
    <name>A0A7D5UW87_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g040780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547426.1">
        <property type="nucleotide sequence ID" value="XM_014691940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW87"/>
    <dbReference type="GeneID" id="26239989"/>
    <dbReference type="KEGG" id="mbrn:26239989"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="381" mass="41803" checksum="1428884A716B62A1" modified="2021-02-10" version="1">MPPKDTDNIKALESLVQTASALLTQLQAVLSEIHKAPDSASASSSSPSPEPDPKINTLSLAHDSASLIRAHGTKISLLIINEPFTPSAVSTVVRELVAGPIPGLVSAAEACAPKQYTAVVRRELAWRAQRVLSELQQLLHKIPNDGKILSESKREGFAKGEKGSLPATGLLWSACDNVIDLAKMGVGGFFIQKVDQWRDILNDVMEEMKEWGDEEPDSDSDSDSDPDVNNLADQLGSQSLSAQAMLDSLMNSHQTIPSSDPDRIRPRLETSLKRLRLVTLLYQALTKRRLKKLPALPPQTPDSNVPSRLDEMAKVLAKLPDSFGDLACAFYELQPSEIDKTMDQCFLDAFAASELFAKDWQDGRDAFSEWTDKFQAEIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWD5</accession>
    <name>A0A7D5UWD5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g039620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547316.1">
        <property type="nucleotide sequence ID" value="XM_014691830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWD5"/>
    <dbReference type="GeneID" id="26239879"/>
    <dbReference type="KEGG" id="mbrn:26239879"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="733" mass="79050" checksum="506C5EE300F79C4A" modified="2021-02-10" version="1">MSAGTEGDAGDAAELTYPSPGAEGMESGPFYHNARDGAPEHHDQAEQQVADEVHGQGHDQTQMSAQDDAASHHHVSRPANLEELQLAAQLGQGLAGTSILPATDPNMTVEDPNMRNIMPHPDPDHHHAASYVQEAPPPDPMVQHQMPVAVGPALPPQYAMGDGIPPRKRSKVSRACDECRRKKIKCDAQSDSGETPCSSCARSSIRCLFSRVPQKRGPSKGYIKELADRIHSIENKLESEGNLSQDDIDKLFATDRSRHSNGLEDSTRKRPFSSISTGDYTTPTTVRQAPWGSEARSAQPASGQGEGLVQEYNNNSLAPQPTPIKPDETPIKPHAAPADVPMVDGDEVPAVDEQAFLEFLASVQPLYPVLPTDLGRLQSLLLQTNAAVRSAFSLALSCIGQPSSDSPKIASSLLHEWESNDSPSSRATDIVHAQTLLILIIDADWRGTSSLPFLLARAVALANSMKLWKCSPVDSTTEPDSDDELCVRIWWSLVLMDRWHAAGTGQPAQIPDRSVVVPASLENTIGEVSFHLLRLSKLLNRISFVISTLQAGLYTADASMAAILTDYIENYREDLPAHIDAAAYPMIHLAYWHCRLLVTMLTPGATPKEIIWPTKELAHLLSVTPELKGPLFSHFVSLATMSLRKLARTEATREEAAEIIKEIAEKPSGGHWDGVKDKLADGLRPASSSAAEAAASQGLQHLADLATASECLAAGEEVPFGAALTTGYLEVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWW9</accession>
    <name>A0A7D5UWW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AVT1</name>
        <name evidence="11" type="ORF">G6M90_00g058060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544383.1">
        <property type="nucleotide sequence ID" value="XM_014688897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWW9"/>
    <dbReference type="GeneID" id="26242795"/>
    <dbReference type="KEGG" id="mbrn:26242795"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="275"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="684" mass="74413" checksum="4BCE141139802719" modified="2021-02-10" version="1">MVPTLRNPTSWDEYEGRASPSGSLWSSVIDEEASLLDSDGDCTQPPVAHHDRRRSSVTTRLAAMADIGGVNSFRSFARSWQRAASFAEVIPRRPSFILPAEAETVPVSSGDEIQYSRSHVDSQPPPQAGLLRQHLEASMPQDSASVQTIPDSGIGVGPAGGIPQEDFRERERKALDTEMASGALHDGSPSIRSNIFAVPPHLATPSLIGSYGSQYGTMGARRYRSRSSASYESAWGVRGDRGGDYGDDVTLGEEQPILVKEIKQGDRVVLTVDGQSTLPQSIFNSINAIIGVGLLSLPLAFKMSGWILGLFILTLTAAVTSHTGKLIGKCMEYDPSIITYSDLAYVAFGARARVIVSALFTLELLAACVALVILFADSLDLLMPTVANTTVWKCVCAALILVLNMLPLRWLSYTSVVGIFSTFCIVCIVIVDGLVKQHTPGSLWEPARTYLLPSNWLSLPLAYGLMASPWGAHSVFPSIYRDMRHPHKWSKGVNVTFSFSYVLDTCLAIVGVLMFGDGIKEAITSNILKTLGYPEFLTILMCIFITIIPLTKIPLNARPLITTADVVCGLHRDHHNPHHHRSGSDAQLSTLANILRAGVRVLVVLILLAISVLFPAFDSVCAFLGAALCTLISVILPICFYLKLYSKDIAKWERIVSWILLIIFSIFGLVGTIWTFLPKQLVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX07</accession>
    <name>A0A7D5UX07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g044070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547741.1">
        <property type="nucleotide sequence ID" value="XM_014692255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX07"/>
    <dbReference type="GeneID" id="26240304"/>
    <dbReference type="KEGG" id="mbrn:26240304"/>
    <dbReference type="OrthoDB" id="5211263at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="32921" checksum="959C2C5D4B3AFBA1" modified="2021-02-10" version="1">MSFVAATCTLIEIVKYMTEALTPWTVLFTHIVKLTCASAILALDVVVYAQEKEYQSLVGIGLDVALFITAITLAIYAILTYRRLSAFDDYVRPANVKGYGFNDGEDADFSYSSRLSIRGSMDKRGTVGSHRPSIGSLRSVKNEPAILNNMQRAPSYYSHERDTQFDEYVARRSSLGARSDFERRTSGDYRRDSPPGDVSPDSLVVTGVVPSRTRGTSITREVSYTSDHVLVAVPEEEHEAPDEAARQDDGTTLLGSSRRNSDEQIMQLHPVLQEADVPEPKWQREGVILDDISIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX16</accession>
    <name>A0A7D5UX16_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biphenyl-2,3-diol 1,2-dioxygenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bphC2</name>
        <name evidence="3" type="ORF">G6M90_00g054150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540989.1">
        <property type="nucleotide sequence ID" value="XM_014685503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX16"/>
    <dbReference type="GeneID" id="26246295"/>
    <dbReference type="KEGG" id="mbrn:26246295"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="194" mass="21944" checksum="DC69F06636E48339" modified="2021-02-10" version="1">MVNNFNQWDGKVLPPSAFAHVVLRTNNLPRMRAFYIEFLGARVVHENDSLTFITYDDEHHRLALVQHPDLSPKVKASCGVDHFAYAYSTLSDLLLSYRHRQRGGMLPFWSVNHGPTISLYYKDPDGNVIELQADNFDTNHETDAFMKSASFAENPVGTDVDPEDLIRRLESGESEVVLKRRVEIGPRSKGPGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXL8</accession>
    <name>A0A7D5UXL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endochitinase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">chiA1_1</name>
        <name evidence="4" type="ORF">G6M90_00g061020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542766.1">
        <property type="nucleotide sequence ID" value="XM_014687280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXL8"/>
    <dbReference type="GeneID" id="26244715"/>
    <dbReference type="KEGG" id="mbrn:26244715"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="15"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="797" mass="82286" checksum="02A815243C78C7EB" modified="2021-02-10" version="1">MSLSLGLGVGGAAPPALNAYWGQTGGRFLRDICDSGVNYATVSFINNSPENGDGYPGSNFGANCAGEVYTNTDGKKTKLLSACSFIQRDIPYCQKKGVKVLLAIGGAHIPGTSEYAVSSEEKGVEFAEFLYNAFGPYKSSWTGPRPFDSTTAHVSVDGFDLDLEDRTPKFKNGPYIAMVNWWRQQSHKMFITAAPECVMFGNQNDELIANAEFDALFIQFYNNPVCDSIPNNTPGDKFSYDEWAAKVATGKSKNAKLFIGLPASTDSAGSGYIDHEAMKDLVCRYHDHKNFGGVSLWDATRAMNNVGAEGKSFLQSAAEAVQYVCGEPPKTTSSAPTSTKITSTTSSTTVKTTSASSEKPTTSNTASEKSATTSTSSASSSAKLTTSSIQSGNVTTSSISSGKPTSSSATSKKLDTTSVIATASATKSATTSSVGMTSSIHWSNSTATRTIQTTSKPVAITTSKPVSMTTSTVYTTSVHTVTECPPTVTDCPVGHVTTEIIALYTTVCPVTETAQPPKPTTTKAAVMTTSTVYTTKTYTITECPPTVTDCPVGHVTTKVIPLYTTVCPVSETAQPPKPTTTKVPAMTTSTVYTTKTYTITKCPPTVTDCPVGHVTTEVIPAYTTVCPVKETETGNVPKPTGPAPSSAATKTTVVSKTVKVQQPSSLATSTRSAAVVPQPSGKGCSGPSCPGATNAPGSGCTGPECPGVAIPTTAPGSGCTGPECPGVAIPTNSWTNKHSSGCTGPQCSGVAIPTNAWTSSSVGPSAVPSSPVTAGASTLALGLTGLVAIVAAQVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYP5</accession>
    <name>A0A7D5UYP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL19</name>
        <name evidence="6" type="ORF">G6M90_00g070240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987029.1">
        <property type="nucleotide sequence ID" value="XM_066130930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYP5"/>
    <dbReference type="GeneID" id="90967927"/>
    <dbReference type="KEGG" id="mbrn:90967927"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="203" mass="23628" checksum="C8743CA5EBAD7485" modified="2021-02-10" version="1">MVDECRKFVTVCNRTTVNLRTQKRLAASVIGCGKRKIWLDPNEAGEISNANSRQTIRKLVTDGLIIRKPVTMHSRSRARELNLARREGRHRGYGKRKGTADARMPSQVLWMRRMRVLRRLLVKYRASGKIDKHLYHELYHLSKGNTFKHKRALVEHIHRAKAEKAREQAIKDEMDAKRAKTKAARERKLERVAAKRNALMAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYR1</accession>
    <name>A0A7D5UYR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fucose-specific lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fleA_0</name>
        <name evidence="2" type="ORF">G6M90_00g064500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540093.1">
        <property type="nucleotide sequence ID" value="XM_014684607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYR1"/>
    <dbReference type="GeneID" id="26247129"/>
    <dbReference type="KEGG" id="mbrn:26247129"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="33212" checksum="0B9FE02DBF02BB19" modified="2021-02-10" version="1">MPAEINDIAMRASVAAINKGSSIRVYESDVFGGIREAMYEGKWTGGGSRNVIAKGKIGSPVAATSLGLDFIRVYYIGEDNKAKEICYDKNGKHWYDGALNNRFKLAPYSGLAAMFLETSEDLKMIRLYGQLEDDNHIQEYCYDTKHGWTVGANLGEAIPGSSIAVATWGTSHNIRVYMQDTSLNIVEKVYDGSRWQTGGLHVKDATPRAALGVTSWMEHSNVSIRLYYGSGSPGNVIKEKGWDHSTGWYDGDFAQGSIPASHVAAIPKPVLRVYIQNGTKFTAVTEFAWEGSWKVGQQALPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYU8</accession>
    <name>A0A7D5UYU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g076710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545432.1">
        <property type="nucleotide sequence ID" value="XM_014689946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYU8"/>
    <dbReference type="GeneID" id="26241465"/>
    <dbReference type="KEGG" id="mbrn:26241465"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="269" mass="29767" checksum="2CB892A269DD08BC" modified="2021-02-10" version="1">MALLSNQNLNCSSNYGEDVVARVNVLASCYIVDSAAQLKGIHYCTTGAAGLPSPPTSPPLAALTSSNELALLPKNKKRDNSGHRRPERRGGAALTIREECERFFCEPMKTAFHGERNLSMNGSGLSGAYLQTPPPESRLSDAFRQSMDIKSQGFEVDAWMEVWDYAGGASFRAFVANNGQEKSLFVFFDIEGAMGRDLKKALMALIELADGPLECAHIVTCIDRRIPFEEAHELTKSLQWVGFEMTTLDHWANHLDVTSKRWVFMGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ68</accession>
    <name>A0A7D5UZ68_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUR7 family protein pun1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g059400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544511.1">
        <property type="nucleotide sequence ID" value="XM_014689025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ68"/>
    <dbReference type="GeneID" id="26242923"/>
    <dbReference type="KEGG" id="mbrn:26242923"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35483" checksum="BFDE526D06F3F8D8" modified="2021-02-10" version="1">MGVGRFICVGLPLALTIASIVALLIATLSGVAHNQLWMFRVDVKDMSISPADLVSITNSLGINPRADKTGNITAADLGLANVYEIDLWGYCYTDNDNKRQCTKAQFDWANSALNTTYIENLGKSAGVQGFKLPDEVKGALKTFRTVAKWTEVAFIVALLALGIQLAVGIFAMCSRVASCLTWLVSGLTSILVGVAAGLSTATASIVVGAIKGSNKLYGIKADIGTRFLATVWIATAFALGAGFFWIFTICCCKPERRRSGGKRNLDSDDEKLIPNGGAYRPLSHNYEMTSGHNNGGYYNPNQNQGGYSSGPRHPSGHGRTDLAYEPYSHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZE0</accession>
    <name>A0A7D5UZE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose 5-phosphate isomerase GutQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gutQ</name>
        <name evidence="3" type="ORF">G6M90_00g075780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545521.1">
        <property type="nucleotide sequence ID" value="XM_014690035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZE0"/>
    <dbReference type="GeneID" id="26241554"/>
    <dbReference type="KEGG" id="mbrn:26241554"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="120"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="437" mass="46981" checksum="C0E91838F49AA0E6" modified="2021-02-10" version="1">MTENCHAERRPIQTSAVIVLGARQRPALPPPSPPTPCASPSDQALVDPTEPFSLEDQERERQHEQQSAQNSYQQCPQESPSKESRLRRGLHVLNTEALALAALTKLYETDSTAREGFDKAVQVITRQALASGKLIVIGVGKSGHIGKKLVATLQSLDIRAVFLHPTEALHGDLGIIDAHDTLLFITFSGKTQELMLMLPHLDDALPTILLTSHTHRDTCEFIKRRPRTILLPAPIPESEQASFGVSAPSTSTTAALALGDALAITVANEIHHNVSAAFAKNHPGGAIGAAAATTAKPPQILGHICVPIADIPSLEGLELSSKATGIDLLRAGFGSKSGWIRMEDKVAAPSRIRKISNTGMNQTVGELPNMFVSRHDMIVMSSDTTIHQAGNMIRTARRDDAEDISCVTESIVCVTDGDNVIGMVEACHLLEVSQHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0E3</accession>
    <name>A0A7D5V0E3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g088990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542218.1">
        <property type="nucleotide sequence ID" value="XM_014686732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0E3"/>
    <dbReference type="GeneID" id="26244732"/>
    <dbReference type="KEGG" id="mbrn:26244732"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="477" mass="52596" checksum="8507D1C5F355ABC8" modified="2021-02-10" version="1">MSSAATLTDAVPVVADPSLIHPEIARPPMPISPYDGHFQHAQAHQFVPSPSLSSSPQPNMARTDSASPFLHNGPFGPNYTTHSPYGAPIDANGRRVSMANFISPVGSADFSSDETKEKQRCTYPDCGKIFKDLKAHMLTHQNERPEKCPIQTCEYHIKGFARKYDKNRHTLTHYKGTMVCGFCPGSGSPAEKSFNRADVFKRHLTAVHGVEQTPPNSRKKTPAGVATGKKLTGYAPDATGKCSTCSQTFSNAQDFYEHLDDCVLRIVQQEDPAEAINAQRLAEVENDKMVHHTLEKNNLPTTTPTIQASLHEDEEDDLDMGEDEDADDVSSKANSSPSIKKKGNPANGVQKSRGLTHSRGGVPTATKTRGRKNRRDYPSSWGFDKGQMTMRKRIMAVFDGPRRLAKDDMMLSTDHEVRIKLSDGKSYVTDLDVQTLKRAEGFLGATDDEKGPWISDDPTEEQLKEMHEMLKTSSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1S0</accession>
    <name>A0A7D5V1S0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g070000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987129.1">
        <property type="nucleotide sequence ID" value="XM_066130926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1S0"/>
    <dbReference type="GeneID" id="26246548"/>
    <dbReference type="KEGG" id="mbrn:26246548"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="226"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="831" mass="90910" checksum="5A770E9A7E55CEDB" modified="2021-02-10" version="1">MRPSCEACQVFQCPCIYDAVPKKRGPKTDVLEALLKRVDGLEAKLKEKNSEGDTVEVEEEEDTDVAEPAPKRLATEASKSSDEDGLKTVTDHEPTARRDINRRCSPNTLSLYPHSDNPASPVETDAYLHTYFARFHGKPYYILDEASVRHRIQSNQLPDSVAFAIWSVASRHTPHSGGTQAALQLSQDYAQRARRCIDTDDLSIDCLQASLLLVLAFMASGHSKKAYMLMSSAIAMAMALELHREIDAHAHVTPVERELRRRLFWTCYLLDRYASCGSRRPSLISDNSVALRLPSWCPSPSSLAVDGEFFQQGSNLQYYQGSGKKSQGSTGLLIDITRILGITNRYLAAGGVKGDSHFPWHSLSTLSKIRQELDFWASGAGPVFSGLQALFHQTEASIVFLSKLIYHLIHCLVYRPFLPVDLAELAGNGQHQSWQIEATNMCFLHANAIGELIDAARHAGTVEWPAIVGYCICTAATVHIHGAHYSNPSAYGGDVNIFSASSNLLSREMKHLSDLHFAWANIRHQSDTLQEIYSAHGELVKAMVASSMRYTPGFHLEEFFERYSNIGGPGGKSYRFDPAHLSMSDIVIDFTADRCSESPVARETERYSHKRKNTLSTKKGNDEGTNAGYDQVAAMSQPTGAGNVPYSIHMTQLPSHVSNGHMQQQVSRPPDAHIKSSGTPFDAAQTIHGYTMPPDNSANNSGQGIVPMSGTRFSPAYSYAMGSNVMNSQNNVNDGNTNFDAMFGALPTNTFSSAAGWQGEDGQQHNKMNIPTSGVAPSPGTKSSSGSTGTGHSEEKDPFLSLLEQLAEDEQRFNGGGADLDFFLTSNNIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V258</accession>
    <name>A0A7D5V258_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g071840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545876.1">
        <property type="nucleotide sequence ID" value="XM_014690390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V258"/>
    <dbReference type="GeneID" id="26241909"/>
    <dbReference type="KEGG" id="mbrn:26241909"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000039">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="470" mass="53917" checksum="1072C9FF1E318916" modified="2021-02-10" version="1">MLSSKQLGPLCDGPYCDIYGLREKLPKLGNDAASDSKLTGDKAHDGAQHVEQDFKSPGLDDECALFPNTSSVLLIMKTGASESYSKIPTQLMTNLKCLPDFLFFSDMAQKIAGYTIHDSLDTVLDEVKEKNKDFDLYYRQKKCPVDQEQCNKDYDVAQQGWSLDKYKNIHMAEKAYKMRPDYDWYLFVDADTYVVFPTLMEWLKQMDPNKPHYIGSVAYLANFPFGHGGSGYLVSRGTMHSMFHGKTGVANKYDEPVQHTCCGDFMWSKALKDETGIPVVNAWPVINGEKPHTIPYAEDEWCQPIVTMHHVVAEDISDLYAFEKERKFKKMLRIKDLYHKFMSPELVEARPDWDNLSEDVNYLNSTRAEYDEWDLAKAKTENLSDAEADAYKSFDDCKKACLSMANCFQFRYQNSICGISHKIKHGKPAKKGNDDSKRYMSGWNVENIKKWVEEQGDCDKHNFEWPVSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2U5</accession>
    <name>A0A7D5V2U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g089540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541616.1">
        <property type="nucleotide sequence ID" value="XM_014686130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2U5"/>
    <dbReference type="GeneID" id="26245479"/>
    <dbReference type="KEGG" id="mbrn:26245479"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028903294" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="814"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="924" mass="101894" checksum="ED0C83EDAC994CFE" modified="2021-02-10" version="1">MSALLPLLALLLCHSAAANAREPVYIKGLGIDGVNRDLEVSRYPALYTGDFDDCLGGESLFNVTKFDAAYYADNLTVLFHLDGTTNIHKENLILHISIEAYGENRFNMTYDPCKANIHSMCPLNNSVPITAFAAIPIAPHDVSGIPSIALGIPDLEGLARLQIFANSTQTQIGCFQAVMTNGNSFSQPEAVSSFLGVMVFIAVLASFATAIYGLSIPHMRVHYAHSFSVLVIFETFQSMFFSGALSVNWPSVLPAWWSNFAWTAGMFANKQIVRSVSSFTGNNVNITQVGGAGSVQINNGGGLLQQIYGRSLFAASPFQNTAGSLKSFAQRNAYNASDPYDYTWGGRPRMPGMPMPGTWPGFSGTLSMVNIPPAEAFTISLIWLLVILAAVALFVGAVKLSLDLLIRLRWLKSDGFDYFRSHVWGYTASALLRTLFIAFFTVMTLAMYQFSLRGSAGPTAVAAIVWLIFLLGIGGITAYACYFRLRHGKYETGPDSLRFERGTVFGKVPFIATTRQSRIGEEEPSRRPYLFGTMPFVKVKYVDDDPNRDPVHLDEGYVKRFGWLSARYRRSRWWFFAFYLGYQFIRACFVGGAARSPLAQVYGLFIFDIIALVVIMKLNPFESNRNTAVAVWMLSISKIVTTGLSIAFLPAFSINRIAATVLGIIIIVVQGFVAIAVLVLILLGVLSTWMSLSRNREDFPQVLEPVRIKYFEHAKACSDDFPPRPKKSDTKEETSEGPREAMFEVRDVRRAPKIEDEGVDKFPDLDPPSISLTTVGASGRRSRANSASSRFSVNSLPRTARVHRASWSSKDIPLWDSEMNRGDQQRVGHSRASSLRLSGYVADAPGTSTPVRRPMTPQQEILEEPQMQQSDGSPTEYTESSQASNPEETKTKDSEEGVSTPATDTEPSEAEEKPRVEPEAKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3A8</accession>
    <name>A0A7D5V3A8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ARO8</name>
        <name evidence="12" type="ORF">G6M90_00g109140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987801.1">
        <property type="nucleotide sequence ID" value="XM_066131773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3A8"/>
    <dbReference type="GeneID" id="26243327"/>
    <dbReference type="KEGG" id="mbrn:26243327"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="213"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="61758" checksum="5570FF9B4A7E5DCE" modified="2021-02-10" version="1">MPVATPHTALPGQPGQSQPAQASSNGVNGNHAAAAAALNGTKNGVTPGSSIIEDILARRAKAGKLVAGIAAASDSDMWKGPQNGKPKAKRWDSHLSKESLERKPCTLKLAAKHLKKPGLISLGGGLPSSETFPFAEFAMKVPVAPHFSEEETLENGQTVTIGKYDVRDHDAVYDLSIALNYGQSTGSAQMLRFLTEHTEIVCNPPYADWRICQTIGSTGALEQALRMFCDKDRGDSVLTEDFSFSTALETIAPLGVKVFGTPIDDEGLVPEAMDMLLTNWDDKERGARKPHVLYTVPSGQNPTGATQGTERRRAIYSVCQKHDVFIIEDEPYYFLQMQPYTGRNQPDVPPPSTVEEFVSSLIPTYVSMDIDGRVLRMDSVSKVLVPGSRLGWVVASEQIIERYQRHAEVASQGPSGFSQIILYKLLDETWGHEGYLRWLMNLRVQYTKRRDALLAACEEHLPRDIVTWTPPAAGMFLWLHVDYAKHPQAATKSLNDVEEEIFNSCIDGGVLVARGSWFLAEKEKPMPGLFFRATYAAASPENMNEAIRRFGQAVRHSFGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3D0</accession>
    <name>A0A7D5V3D0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ANXA7</name>
        <name evidence="6" type="ORF">G6M90_00g100380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="domain">
        <text evidence="4">A pair of annexin repeats may form one binding site for calcium and phospholipid.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546312.2">
        <property type="nucleotide sequence ID" value="XM_014690826.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3D0"/>
    <dbReference type="GeneID" id="26240735"/>
    <dbReference type="KEGG" id="mbrn:26240735"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018252">
        <property type="entry name" value="Annexin_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00223">
        <property type="entry name" value="ANNEXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0111">Calcium/phospholipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="444" mass="49574" checksum="1DC3E2331E06A7EA" modified="2021-02-10" version="1">MSYQGYGQPYGQPPPQAGYGQYPPPQGQYPPPQGQYPPQQGHYPPPQQGGYYQQPPPPPPGHYPPPHQQSYGQQPPPPQHFNAPPPAPSPYGHHSPAPPQGQYGAPYGAPPPQQYGHSVPATPPSKGYGAPQIIQWDANPDAQALRAAMKGFGTDEKALIRILSTKDPLQIDLIRTTFDRTFKRSLIDDIKSETSRYFEDGLVQLAYGPLLADVHNLRDAMKGIGTKESVLNDVLLSRSNADIKAIKGAYRQQFGRSLEQDVKGDLSMKTERHFLMVLAANRAEDAEPVDPRKVDDAVMHIYQATEGRMGTDEILVCQILTSHNDNQIRAIAHTYKQKFNRDLAKVIDSEFSGHMRDALLFQLGHAVDKYMHAAELLEETMRGAGTKDFLLVLRVVRLHWDHTMLSNAKAAYQQRYRRSLASRIDGEVSGDYKRLMLACIGEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3M2</accession>
    <name>A0A7D5V3M2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acu-15_3</name>
        <name evidence="8" type="ORF">G6M90_00g107380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987873.1">
        <property type="nucleotide sequence ID" value="XM_066131727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3M2"/>
    <dbReference type="GeneID" id="26243489"/>
    <dbReference type="KEGG" id="mbrn:26243489"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="723" mass="81249" checksum="A6850419ED137FE2" modified="2021-02-10" version="1">MDTEYKRKRVAKACQRCRSMKSKCDGQRPACSRCRGYGYTCIYRLQRPRLRAGTSDRFSPGVSEGLPDLHDAIHQQERLLNHVISLLPSGPEQEAVLLKSSRIKSQLDDVISSTRAEVTPRAVASDACGKSPSSHADRSPGYLGEVSDIRFVNLVKQFLQTQDGSTRTQEDFESYDQGESLVSPDKAAGKTILLPVLEEAQQYITAYFTTIHVAYPFIPESRFMQDYKTLRDQDSPQTQNDTICAIGAYYRTLPGKDETDDGLHEKYFLCALTLAPTTNLERSLAQVSLLLARCFYLLVVCKTESCWTILGQAVRVAQSIGLHVENDDIDHTKLNHSLEIEERRRVWYSIYVLDRLLSLQLGRPPAIHDDDFNVPLPARASDAEIDWTGDVVEEKTDNTPSSGDYFLAVIAFSGIVGRVLRGLYCPRRSHFASEDLLNTKDLDRQLVQWKLALPRVLRFDLGHTFEQSHIFSRQRNMLAIKYHHLRALIYRPYLCHPLLMHLGDPAATISQLDWPLIRANERTCIMEARETARLLHGISSKEDLVHDFPWWQMISCLVCASSILLVSSMFAEESLELSPELDTVGLSDDAETCLKVFDALSKNSPGARIARDMMKALQECGVRWKDASGSTPKTSREGVKAFSHSPDFQSQPSYMSAMPASLHVGDYGQHFAASGGPMPTNCYWPAEIVDSMAWSAQFFDFGHGRSGHTEGVEQSRSENNESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V499</accession>
    <name>A0A7D5V499_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High osmolarity sensitivity protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g090870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987474.1">
        <property type="nucleotide sequence ID" value="XM_066131385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V499"/>
    <dbReference type="GeneID" id="90968107"/>
    <dbReference type="KEGG" id="mbrn:90968107"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9430" checksum="E27ADD6B649583C4" modified="2021-02-10" version="1">MATRNFGATQNLNRQSMAPGAGSAAKNRQLAHLQSQLAQLSTNLSDTENLLRMTSVQAEAMRGLGSWHGGLFMAASKVLGEESVREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4K1</accession>
    <name>A0A7D5V4K1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g111380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543726.1">
        <property type="nucleotide sequence ID" value="XM_014688240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4K1"/>
    <dbReference type="GeneID" id="26243113"/>
    <dbReference type="KEGG" id="mbrn:26243113"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="523"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="69539" checksum="89539EA85F7AC1B4" modified="2021-02-10" version="1">MTANPASQSRKRPVRIANCSGAVSDPGVYMYNQAKYGSVDVITGDYLAEANMAAEAEKLAGEPDSIETGWVRTALEGLRLTLDLANEKRIKIIVNGGGLNPRGLAIKTHNMIKDKQLDLRVAYVDGDNLMQKVHSILPDAATASKIHLDSANKHVQLAEDALSFLQDPEHMPIVAANAYLGYRAIKRALDEAADIIICGRVADASPVLAAAAWWHGWEETDYDELAGALVAGHLIECSTYATGGNFSGAYKYPVGALINLGPPIAEVAHQGECVITKHEELGGFVTPDTVRCQLLYELQGNIYLNSDVKADLAGVKVQPQAAKNRVHVSGARGHPPPPTTKLAVFYKGGYQLEILMNACGYATDHKWDVQEAQVKSKLDEWGLLDSLDVLDFQRVGTPQENPVSQLASTTYMRIFAQAKDRSVCRAVAGAWNFVFMSHFPGAHCSWDLRTLEPKPFLGYLPTLVDQAEISEAATVLTDADDASKLRRMPVGPPRLTEPLLPRLNYETADPVPLASFGPKTMRPLGDVVLGRSGDKGGNVNLGLFVQTRDQFDWLRSFMTRDKLRELMRGDWRDWYFVERVELPGILAVHFVVYGALGRGVSSSGLLDNLGKGFGEFIRAGWVPVPTRFLHESAAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V563</accession>
    <name>A0A7D5V563_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NUS1</name>
        <name evidence="14" type="ORF">G6M90_00g099490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546398.1">
        <property type="nucleotide sequence ID" value="XM_014690912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V563"/>
    <dbReference type="GeneID" id="26240821"/>
    <dbReference type="KEGG" id="mbrn:26240821"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI73619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="327" mass="37228" checksum="4A313B6699C75876" modified="2021-02-10" version="1">MPMSARDRAAYRADNASDHKFLSDKERERIIRANLPNPNEIPTVAASKAQSQRRSRLGVRRFLKTQLYALVFAIMHGLFSLYIRIRQAIHIVSYQVSSVLYYHHGTPEYIRRDIIGLGRKPNHLSAILKAEENQRPKADLDRLIEETAELAAWCASAEIPMLSIYEKTGILKKHMPRVYEAVMQKFTFYFAGQHPSLLLTSPHKDAYSSPALAGDKHGHLKLHLISAQDGRESIVDLTRTLAEMSQRGKISPRDISMELVDAELSEGIMPEPDLLILFSPNVELSGYPPWQIRLTEIFCLQDNEGFGYQVFLKALRKFAKAQMRNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5Q4</accession>
    <name>A0A7D5V5Q4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g094250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540790.1">
        <property type="nucleotide sequence ID" value="XM_014685304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5Q4"/>
    <dbReference type="GeneID" id="26246403"/>
    <dbReference type="KEGG" id="mbrn:26246403"/>
    <dbReference type="OrthoDB" id="4937615at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="35044" checksum="44925267F6A6AE5E" modified="2021-02-10" version="1">MDSEWEQRAEKALKMTSQPFLDDNIMDHECPPSCAKSDLKRPRLRKFPFDLDSISFVGGIYPYRGRNVCTGQGLDGGLDGYNWKIRVRNAGPTHVLKLLWDTEPWYPHYFAPQRECQNAALLQAMEAAVADAARPDNANGPILVNPEPKTWDEAYKNMLAFSNEARRRRIGVQSHDLLSITSMPRMRKCYGWMQFTGEELLRHLPRRLIPPYVEVDKVVRSIDDEKLYTAVVYEFIQEADNDVDVVKSVLEFLSHAGFCHRWPKADNWKGGVLVDLSDIVNPRSYGWREQGCGRTDPSFVLETYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5Z2</accession>
    <name>A0A7D5V5Z2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kapA</name>
        <name evidence="11" type="ORF">G6M90_00g096850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546651.1">
        <property type="nucleotide sequence ID" value="XM_014691165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5Z2"/>
    <dbReference type="GeneID" id="26241074"/>
    <dbReference type="KEGG" id="mbrn:26241074"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="335"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="551" mass="60308" checksum="3C107C3297D12B5C" modified="2021-02-10" version="1">MAERYIPEHRRTQFKAKNTFKPEELRRRREEQQVEIRKAKREENLAKRRGIGTGENRPGASLGAAPDSDDESAPTESQLNEDLPQMVEGVFSDQVDLQIQATTKFRKLLSKERNPPIEEVIKTGVVSRFVEFLRSRHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLASTEPDVREQAVWALGNIAGDSPQCRDYVLSCGALKPLLNLLGDSRKLSMLRNATWTLSNFCRGKMPQPDWNTIAPALPVLSKLVYSLDDEVLIDACWAISYLSDGSNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDIQTQVIINCGALPCLLSLLSSTKDGIRKEACWTISNITAGNTSQIQAVIDANIIPPLIHLLQNGDLKTRKEACWAISNATSGALQKPEQIRYLVAQGCIKPLCDLLTCPDNKIIQVALDGLENILKIGDLDKQAAGESADTINRFALFIEECGGMEKIHDCQNNANEDIYMKAYNIIEKYFSDDEENADEGMAQPAGPNGTFGFGTNGAAQSGGFNFANGGDSMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNG7</accession>
    <name>A0A7D5YNG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g048130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544928.1">
        <property type="nucleotide sequence ID" value="XM_014689442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNG7"/>
    <dbReference type="GeneID" id="26242269"/>
    <dbReference type="KEGG" id="mbrn:26242269"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12359" checksum="BC31390E74ED8952" modified="2021-02-10" version="1">MSRRQARTSVRFSTYSMTPSFTPTVQTSDTAQAEISDIALNLDRMENKALSSQRVMLSDEKTDNMSKLALGAKLDRALGRRMSGQDAVMRPRRNVSVSVTMSEKKALSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPP5</accession>
    <name>A0A7D5YPP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g018620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548678.1">
        <property type="nucleotide sequence ID" value="XM_014693192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPP5"/>
    <dbReference type="GeneID" id="26238122"/>
    <dbReference type="KEGG" id="mbrn:26238122"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="61751" checksum="0022739B63D371D2" modified="2021-02-10" version="1">MALISRYLPFAPSATTAQAVTYLLGISLFSISFLVFLNSSVSFVITDLIGQKKNVGDVVGTLGFADEIVALVACPAWGLISDRLGVRWVAVMGYAVIALALVLFVQAKNVYPQLLLARIFFAVGASAAATMVTAILPSLTDEGDLSDGRSPSRYKPNQRLSVAFSVESEATITPERYTRSLSNDSRDSRQQQDAVAKSAKPSALAGLVGLFTGCGALVALSLFLPLPARFGDIDGVTPGQAVSYSFYVVGAVSLVVALFVFIGLRNLKGEEGKGWTVLFGISERDAYARLGENGEDRTQRQKTIPYLHLMKDSVLLGFADSRIALGYIGGFVARASTVAISLFIPLYINTFFISNGFCQGSPNDPSPELKKECRAAYVLSSILTGVAQLMGLVCAPVFGYLSGRAGRVNYPVVVATVFGMIGYLMLPQLPSPEFKDVDDRGGTPFIFLVVALIGVSQIGAIVCSLGSLGQGVIAVELPRSVRREPSIAPGEDESAESEPLMRRSTNEDSASRVRLKGSIAGVYSLCGGAAILLLTKLGGVLFDSVSRGAPFYMMAIFNGALLVASLCMDASQAFATANQGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPR1</accession>
    <name>A0A7D5YPR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyoxalase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g031710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543109.1">
        <property type="nucleotide sequence ID" value="XM_014687623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPR1"/>
    <dbReference type="GeneID" id="26243910"/>
    <dbReference type="KEGG" id="mbrn:26243910"/>
    <dbReference type="OrthoDB" id="4937445at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19430" checksum="88959223082B1122" modified="2021-02-10" version="1">MESVGAVEATLSSAATTIALVHQGMATHKLGRAGTKNLLGQVADRGPVDGRLIDQARKDRRTEQYAYYLLSEYARLLEWLADQHFSVPAAAVSWYDPRRVVVGAYRVPLVFANRRSRELKELVDSIKELAGELVAENIQAAVNALPTTLSGGPLLKEDFTALERRTEAARVRVKNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPS3</accession>
    <name>A0A7D5YPS3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g028640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541302.1">
        <property type="nucleotide sequence ID" value="XM_014685816.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245937"/>
    <dbReference type="KEGG" id="mbrn:26245937"/>
    <dbReference type="OrthoDB" id="4960252at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="167" mass="18381" checksum="D1CE7F2E046F5A04" modified="2021-02-10" version="1">MAGIYTKLDSQVDLHGFTDADREAKTDSPSAEIPVEESNKPDTAARDEKSTTHTRSAWSLWKWEIISIILGGGVIAVIFALLRIYENKALSEWRAPISINTVVAILTALFKGVLAVPISGGLGHIKWLLFSKQDRSLADMDRYDHASHGAWGSAILVFNQFRGRSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQ05</accession>
    <name>A0A7D5YQ05_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CHO2</name>
        <name evidence="19" type="ORF">G6M90_00g022760</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548279.1">
        <property type="nucleotide sequence ID" value="XM_014692793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQ05"/>
    <dbReference type="GeneID" id="26237723"/>
    <dbReference type="KEGG" id="mbrn:26237723"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI65322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="973" mass="109952" checksum="1E6ACA841F9977BB" modified="2021-02-10" version="1">MSKSTGVDAEASELRQRQTRDSPIVTNQPQAVAVESLSTEDGPDHDKPKSNSKTFGRTPDGTIFIVPTTHDMVSQLLDPRQPKNLSDAVVLGILAFMILVAYSLPAGWKRPVFAVTFLFWRGCYNVGIGVLLHIQSRHRRLITWAKRWKLFEDPKTGNNPRPWLYNLLKRELEAKIPEDYEFEKAPLEYNTWLVFRRVVDLILMCDFVSYCLFAIVCGHTPEGENIIVGAARWALGIALVGFNLWVKLDAHRVVKDFAWYWGDFFYLIDQDLTFDGVFEMAPHPMYSIGYAGYYGISMMAASYEVLFISIIAHAAQFAFLVTVENPHIEKTYNPPLPRKRDLSRLQSDSNVSPDMSDHNSTDRPASTPKMATQEPPVPVHNMVGFRNMDLFRVPDSMVVLLPMYVAILTLATPTTPAWQAFFVAHALLWRVWYHLGLSIILDKQSKTKMWTRHFLKYGESAGEAWRQWKGLHHISMIMCNASFVAACYKMYSMPSDWGYGLVLLKHVLGGGLIALQLWTAFSVYDSLGEFGWFCGDFFWDQEAKLNYTSIYRFLNNPERIFGTAGAWGGALITWSRAIFIMALVAQLLTLYYISYVERPHMQKIYGRSMRGEAGLTKFIKRALPPPVKGWQESVDKVLDDTTHFVEDFIDSARPKFASGVKTIVRDTSALFNIAPARITLTKIPADLAGLDPKLYSLSVEGTPSALSNIHDRATGKESFTGRFPKHVKTMAYEYGAPLRVKWRAPANHSDKDWIGLYMVTDNRSRESTEVPSLGRWAPTNEGVYDALTADSSIVTPEHPSPKSDSSEPDMVEGEVEFNGDKLWWTQGVFEFRYHHNGRHMAMAISEPFEIRIAQFAEDDVDLDSKGMYAEAVEAAILPVVRNCFDRDPDIAPCTVDEPFGSYVERDGKYAKRIVYAIREMFGIEFAPAVVLADGNVQKLAWRICNAKEVLAPYSMSHSKGSATPAAQEFDNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRG4</accession>
    <name>A0A7D5YRG4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">G6M90_00g041230</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547469.1">
        <property type="nucleotide sequence ID" value="XM_014691983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRG4"/>
    <dbReference type="GeneID" id="26240032"/>
    <dbReference type="KEGG" id="mbrn:26240032"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="71"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="413"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI66821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="609" mass="64733" checksum="DE63606381FE73C0" modified="2021-02-10" version="1">MADTGGESNIPAIPGHDPKSSADYIQFKCLPPGGPLNRWSTTLTREHDFPGAQAMLYGAGVPDEKTMKNAPQVGIASVWWEGNPCNTHLLEFGKIVKNAVEREGMLGWQFNTVGVSDAITMGGDGMRFSLQTRELIADSIESVTSAQHHDANISIPGCDKNMPGVVMAAARHNRPFIMIYGGTIRKGHSTLLERNVNISTCYEASGAYAYGRLQAKTDAGQPGRQSTDVMSDIEKHACPGAGACGGMYTANTMATAIEAMGLTLPGSSSYPALSPEKSRECERAGQVIKTTMEKDIRPRDLLTRAAFENALVLTMILGGSTNGVLHFLAMANTAGVPLTIDDVQRASDRTPFLADLAPSGKYLMEDLYQVGGTPSVLKMLIAKKLIDGSVMTVTGRTLAENVSDWPSLDPGQQIIRPLEDPIKSSGHIRILRGNMAPGGAVAKITGKEGLLFTGKARVYDCERDLNTALSRGEIKRQDGNLVLIVRYEGPKGGPGMPEQLRASAAIMGAGLNNVALVTDGRYSGASHGFIVGHVVPEAAVGGPIALVKDGDEVTIDAVRNRIDAAVSDEEMALRKASWRAPSPRVTRGVLAKYARLVGDASHGAVTDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRX5</accession>
    <name>A0A7D5YRX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino-acid permease BAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BAT1_0</name>
        <name evidence="7" type="ORF">G6M90_00g041040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547450.1">
        <property type="nucleotide sequence ID" value="XM_014691964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRX5"/>
    <dbReference type="GeneID" id="26240013"/>
    <dbReference type="KEGG" id="mbrn:26240013"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="539" mass="57608" checksum="7F57B27BFBAA0171" modified="2021-02-10" version="1">MKPAVSHASTMEPRRPSASDAADAALASLGYKGELPRNLSMMSILGLSFAIMAVPFGLSTTLYITLYNGQSVAVLWGWVLVSLISICIAASLAEICAVFPTAGGVYYWSAMLSTRRWAPMVSFVDGWLTLVGNWTVTLSINFSGAQLILSAISIFNPDYVANQWQTVLCFWAVMLVCAAVNAFGSRYLDLINKVCIYWTAASVLIIMVTLLVMAPSRHSGAYVFGHYDASASGWPAGWSFFIGLLQPAYTLTGYGMVAAMCEEVQNPEREVPKAIVLSVVAAGITGVIYIIPLLFVLPDVAILLQQTQPIGLLFKTVTGSAAGGFGLLFLILGILMFAGIGALTAASRCTYAFARDGAIPGYHLWSRVNKKLGMPLWALALSTVVDCILGCIYFGSSAAFNSFTGVATICLSMSYGVPVLVLLVRRRELVKSSPFSLGKFGTIVNIICIVWIVFAVVIFCMPVSLPVDSSTMNYASVVFAGFAAIAIAWYFAYARRNFHGPPVLGNGEFVPGVTGVQHHGAEAIVGTDSETPDPASEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSN6</accession>
    <name>A0A7D5YSN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HTA1</name>
        <name evidence="16" type="ORF">G6M90_00g042420</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547579.1">
        <property type="nucleotide sequence ID" value="XM_014692093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSN6"/>
    <dbReference type="GeneID" id="26240142"/>
    <dbReference type="KEGG" id="mbrn:26240142"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI67881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="135" mass="14211" checksum="8E7916CDCE807F2B" modified="2021-02-10" version="1">MTGAGKSGGKASGSKNAQSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKTGGKSGKNASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT52</accession>
    <name>A0A7D5YT52_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THUMP domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">THUMPD1</name>
        <name evidence="4" type="ORF">G6M90_00g042680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986594.1">
        <property type="nucleotide sequence ID" value="XM_066130305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT52"/>
    <dbReference type="GeneID" id="26240167"/>
    <dbReference type="KEGG" id="mbrn:26240167"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="165"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="314" mass="34927" checksum="F0B56EA62E10F80A" modified="2021-02-10" version="1">MDSTSRKRKDGPVPANGSTQPAHKKSKGGSAGRWKTPHQKAKIAEKVELGTTLAIGDQGIWVTFARGMKYKAIREFQELCVEYGKTMYGIEPPANDDEIAQGDEHQDIEASIEAELSSMKSGGKADTNQTFKPVSSGVECLFFMKTMDPVQPGSLAKKMCEDARDCQDQRQRKCKYINRLTPVVNMDKATDKGIDKVARAVLSPWFELKDEEKGDADKTEAPPSAVPSPPYTYAIRHNIRNHTTFKSGEVIQKIAGLIDAKHCVNLSKPDKVILVEIFQLFCGISVVDGKEWEELKRYNMNELYSLTPVIGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU17</accession>
    <name>A0A7D5YU17_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type I inositol polyphosphate 5-phosphatase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IP5P13</name>
        <name evidence="4" type="ORF">G6M90_00g091400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541788.2">
        <property type="nucleotide sequence ID" value="XM_014686302.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245256"/>
    <dbReference type="KEGG" id="mbrn:26245256"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="3">
        <location>
            <begin position="49"/>
            <end position="462"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="541" mass="60044" checksum="2E69EF4366E15ACB" modified="2021-02-10" version="1">MSTWTLLDVEQPLSLASTNSSSRTRAGFVSDDNPRSVDGSTKEAAMAPSTLGLLMLTFNCAKKLVNVDVLANHVHTAFTNNATTLPDVVVFALQEVAPLSSAFISSRYLEEYFARFNDAVNLAARQYESNGTPREEPLVSVAQTVSGPEPPSPQRRSYTLVAAHNVGYTAILLFARDPDRIRNLKHAEVGFGTAEMGNKGAVGIRALYDVDGTGARCTEVTFVAAHLAAMEWNLARRNANWAAIVRGLTFGDPEVILNDLRGPEGAREPAQPAENNDQGTEGHRLLHDVHDEQHVQVQRAMHDISVFKPSSHLFLAGDLNYRISTSSPPPDAVFPSLDPSSPNYYPAFLPLDQLTRERRAGRTMHGLSEHQVSFPPTYKYDVQPKLSVVPDQDETEVPWKFAKHRYPSWTDRVLYLDLPPWVKSRGDHPSMNVIAYDALPLLRSSDHRPVYLRVEVPLIPPHDLSPPASTEHTADGETLKDPRVRLPIEVDPEAWSRRRVARQWELAVGWGAFLGSTKEGAWIWATLLAGGVAAWWLYKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUE8</accession>
    <name>A0A7D5YUE8_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547970.1">
        <property type="nucleotide sequence ID" value="XM_014692484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUE8"/>
    <dbReference type="GeneID" id="26237414"/>
    <dbReference type="KEGG" id="mbrn:26237414"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28947" checksum="44B73E0B4901E3ED" modified="2021-02-10" version="1">MNGNGNGVIADEEQPLLGRKPSPPSLLSKCRKQMTAEVSRSWADLVLLLCYVVTGLLDSASTQVWGAFVSMQTGNTVFVGLGIATVFNPPVSARLYKSGVSLLSFCVGSFFFARFHRYFSPKRRWVLCASFAAQALLIVAAAVVVTVWPAPGDERAVGWTVLVPLALVAFQSCGQAVTSRALRYNALTSVVLTSIYCDLFSDQDLFKVRNVERNRRAAAPALLLVGAVAGGLFSHSSFGIQGALWAAAGIKSIMVVLWFFWPTEDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUT9</accession>
    <name>A0A7D5YUT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684024.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247674"/>
    <dbReference type="KEGG" id="mbrn:26247674"/>
    <dbReference type="OrthoDB" id="5153211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028945561" evidence="1">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34487" checksum="548D801C226B2A81" modified="2021-02-10" version="1">MKLSVTLATTLVGLAAAAPQNDPVPEELAAKVEEVLRQVEVKNKEADNGGIGGTINDVVKQIVPQAAGNLYPPIGQGASIVALLATSEYKFDEANGKEWLKNLGGLALSFLPKVATLGNLPGFIGMIKTIATGIEAAQFPELTAKRAAAAKCFADNSQKTYNDVCANCKPELAMSLLARLNKCTDENVVSRNAYEDNKFAQSFCGTVLCSGHKEGDIDNIIKQGFRYDPVRAFWCKEKEEIIGMIMSPWIGQPLLENYHKLDHEDLREALTEPCQQLFKVQGLQIDGVCPTRAEFDEANTRSVPQSFCAPGKKITPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV03</accession>
    <name>A0A7D5YV03_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ap1b1_1</name>
        <name evidence="9" type="ORF">G6M90_00g043510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547685.1">
        <property type="nucleotide sequence ID" value="XM_014692199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV03"/>
    <dbReference type="GeneID" id="26240248"/>
    <dbReference type="KEGG" id="mbrn:26240248"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="642"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="748" mass="81484" checksum="2FA363D5FD38A7D7" modified="2021-02-10" version="1">MAVNRIRGAFAAPRKGETFELRAGLVSQYAYERKESIQKTIMAMTLGKDVSALFPDVLKNIATADLDQKKLVYLYLMNYAKSHPDLCILAVNTFVQDSEDPNPLIRALAIRTMGCIRVDKMVDYMEEPLRKTLRDESPYVRKTAATCVAKLFDLNPAMCIENGFLETLQEMIGDPNPMVVANSVQALSEITETAPETRALVVTSATLKKLLMALNECTEWGRITILTTLADYPASDVKESEHICERVVPQFQHVNPAVVLAAVKVVFIHMKAVNPELVRSLLKKMGPPLVTLVASAPEVQYVALRNIDLLLQAKPDILSKELRVFFCKYNDPPYVKLQKLEIMVRIANEKNYEQLLAELKEYALEVDMDFVRRAVKAIGQVAIKIEEASAKCVQALEDLLATKVNYVVQEVIVVVKDILRKYPGYEGVIPTLCEHIDELDEPEARGSLIWIVGEYAEKISNADQILESFVEGFMEEFTQTQLQILTAAVKLFLKKPSNTQGLVQKVLQAATAENDNPDIRDRAYVYWRLLSGDLDVAKNIVLSQKPTISTTMTTLPPSLLEQLLSELSTLASVYHKPPESFVGKGRFGADEIQRAAIQEQRQNAADNPIAASVAAAANGAGPGASSNNIENLLDIDFDGAAPASHEQQSASATPDRVASPAGGAASGGMADMMSMFDAPPIDATNNGGAAGPSSGSGINDLMGGFDGLSFGDSNSSQPLPAAMQLNNAQGGSSTQTQKKDSDDLLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVH4</accession>
    <name>A0A7D5YVH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547141.1">
        <property type="nucleotide sequence ID" value="XM_014691655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVH4"/>
    <dbReference type="GeneID" id="26239704"/>
    <dbReference type="KEGG" id="mbrn:26239704"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06197">
        <property type="entry name" value="FNR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="347"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="605" mass="65167" checksum="9DC8311BC775087F" modified="2021-02-10" version="1">MPSLVSSFHEGEAAMRDMLKVPPGSNPTAPGLPTPYALRVRQSPLVALGTLDEAGRPWTTIWGGERGFAAPVAEGVLAFNSAVDMRHDPVFEALWTEQGLEDGIVRPNGGRGKMMSALSIDLETRDRVKLGGVMVAGAVVHEDDGRDAVQAAMVVTESLGNCPKYLNKKEIVKHDPGGAHLAGDGLPLPQEALGLVYKADNFFLSSTNGETMDTNHRGGRPGFVRVVRNEGSQVELVYPEYSGNRLYQTLGNLKVNPLIGVVIPDYDTANVLYLTGRADILVGREASSLLARTQLAVKMTVSAARFVKAGLPFRGVQGEYSPYNPPLRHLVSERDDARAVIDDPSVHSDVTASLVDRRVLTPSVSAFTFKLSSATGQALPTWEAGQHVSLDFEPELGFGYAHMRDEDPQSINDDFVRTFTVSSPPGWRDGAFQITARRHGPATGLLWRQNIRAPLDIPVLGFGGEHKFRLPVRKGERPVYVAGGVGITPILAQAGNVLDAGVQLSVLWSLRGEDLGLAADTFALIPGLAGVTTLYITGAQADEEVVQKLKGLGLLAVESRRIGADDVKAYMGDKRRFYLCASPALLALLTGWLAGEDVVWEDFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVL7</accession>
    <name>A0A7D5YVL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g094990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540860.1">
        <property type="nucleotide sequence ID" value="XM_014685374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVL7"/>
    <dbReference type="GeneID" id="26246473"/>
    <dbReference type="KEGG" id="mbrn:26246473"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="356"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="546" mass="60672" checksum="EB4A45DBEFA9ABED" modified="2021-02-10" version="1">MSNPSIEDYTIGWICALQEEYDAAARMLDAEFDGPDTAEVNDNNSYVYGRISGHNVILGCLPGGQYGTNSAARGGAPTAGKDIRLGDVVVSQPQGKLGGVVQYDLGKRLPGGRFEQSGQLNGPPQVVLGVLPEMRRRHNDSRKPDRIAQHVKRMDEEPDYQRPADDRLYRADYPHQGGEDCSKCETCEVVQRPPRSSNRVVTVHYGTIASANSVMKNAKDRDEYAQDPALNVLCFEMEAAGLMNSFPCLVIRGICDYSDSHKNDEWHNYAALAAAAYARELLYILKPQKVYGAPSWAGKMEELLAGIQGHVMHMSRGVDDLICQNRDQADETILNWITKIDHGSYHSDIANKRQPGTGQWILESGKFQTWLKTSKQTLFCTGAPGAGKTILTSVVVEHLTTRSQSDRNIGVAYLYCNYNRQNEQQLNSLLECLLKQLAERRRSVPECVKSLYNCLRAEHMRPSVGQLSSALDAVVSLYSKVFIVINALDECRNTDGSRAELLVETVRALQKPCGVNIFETLALETSSAWYQIVEAKNIVPWRCGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVZ7</accession>
    <name>A0A7D5YVZ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g076820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545421.1">
        <property type="nucleotide sequence ID" value="XM_014689935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVZ7"/>
    <dbReference type="GeneID" id="26241454"/>
    <dbReference type="KEGG" id="mbrn:26241454"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="467" mass="52326" checksum="1B701D18E7A94C92" modified="2021-02-10" version="1">MAEKKADAPAAGMLWGGRFTGAIDPLMYKYNASIQYDKALYKEDILGSIAFARANSKAGIISKDEFQAIERGLLQVMEEWTQGTFTIMPNDEDIHTANERRLGEVIGKDIAGKLHTGRSRNEQVVCDMRMWLRDRIREIDSQLVAFLKVIVTRAESEIDYIMPGYTHLQRAQPVRWSQWLMSHAAAFKQDLERLRQVFERVNLSPLGCGALAGNPFQIDRNIIAEELGFSGITLNSMNTSADRDFLIDFLAWNSIFTNHVSRWAEDLIIYSTSEFSFVRLADAYCTGSSLMPNKFNGDSLELLRGKSGRAFGQMAGLMMTVKSLPSCYNKDLQEGWEPMLDSVQTVSDSLGIANGVIATLKVRPERMEAALDKTMLATDVAEWLVRKGCPFREAHHISGRVVAQSEKLQISMDKLTLEQLQAIDSRFTADIAEAFEYETSVEAKTSKGGTSRSSVLEQIQVLRAMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWC6</accession>
    <name>A0A7D5YWC6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ppk23</name>
        <name evidence="12" type="ORF">G6M90_00g088190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542296.1">
        <property type="nucleotide sequence ID" value="XM_014686810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWC6"/>
    <dbReference type="GeneID" id="26244810"/>
    <dbReference type="KEGG" id="mbrn:26244810"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="113"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="471" mass="53108" checksum="E52E863CB80F069E" modified="2021-02-10" version="1">MASKGKSRWADTEEDAQLDARLKQEKEEKRRKKAEKARRIEADKQTALAASSRGPESSRDNEIDRPSKRRRVTPETGESTTQGSTSSNDPKPIKLLRFEDTGTWRKSRSVDNYDKLNDIEEGTYGWVARGTERATGKIVALKRLKLEPSDRNGLPVTGLREIQILQDCKHRNIVHLEEVVVGEDTSKLDNSIFLVLEFVEHDLKGILEDMPEPFLSSEVKRLLLQLTSGVSYLHENWILHRDLKTSNLLLNNRGQLKIADFGMARYVGDPPPKLTQLVVTLWYRAPELLLGTRTYDAAVDMWSVGCIFGELITREPLLQGSNEVDQMSKIFELCGVPTEESWPGFRKLPNARSLKLPKNALSNGSVVRARFPSMTTAGASLLNDLLALDPVRRPSAKDMLSHEYFRQDPKPKPESMFPTFPSKAGQERRRRHEPNAPVRGQAVALGDVDLSGIFQGRDKEERGAGFTLRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWW0</accession>
    <name>A0A7D5YWW0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g020540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985779.1">
        <property type="nucleotide sequence ID" value="XM_066129857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWW0"/>
    <dbReference type="GeneID" id="26237936"/>
    <dbReference type="KEGG" id="mbrn:26237936"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="870"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="956" mass="110128" checksum="BA3AE5709E05BA50" modified="2021-02-10" version="1">MASGHYGSVLVTTLEEFKKNLSKRDIEEFKRVTKQEFDASIGNLQARQHSQRRLQNMSRLKRFLETMEQFWNVAQVLCDHGEIIAFVWGPTRRLLQISSSVAEAFGQVLDTYERMGDNLPLLGHYRDFFLTEPHMVQILQQMYLDILDFHRIALQYFQQPQWERLFNTTWKTCKCRLSDKISKIARHRSLIESRATPSQVEESQRVGQREDCQRDQEMDFEQESRFRAVCSWLNATSIETDQYYHSKIRSEYPGSGRWLLDNATFKEWFDPQFPTIPPLLWLNGIPGAGKTILASLVVEEAQKLPTKPTVLFFYCKDSNSERDNFLALGRSLLAQLLKSDKGLQPYFYQECCGSTGAVLTSPGVVENLLILAFKNCPSAYIIIDGLDECVREQRKHITQWFRKLVEDLPSDNPDRIRCLFVSQDDRHARKDFTGLASIKMSPEDNKGDIDGYSQIQAVEVQRKFQLSDQKASEVSGIVNNSARGMFLLAKLIWLNLLGQTSVSGLEEELEERIFPREVNDAYRRIMHRIKTQASRAELRDALMLLGWLVCAKRPLRWHEVQGLKSINLDKLSVEYERQRFVVAPKDLCESLVEVRVDGTLEFVHQTVKFFLIEDKHVDQPVEELKMACLCIDYLNLPAFIQPPTQDAVLNGDYVFMDYAVLYWIRHLEAGVVHADAHQQLMNQLAESLEVFIHHHWSSPTAKFAVSNGNRDRLQFFKGLPFYDKLEKTIISTRKQLSFFGQMKQGEIALNLANIVVKVRAVMESILSSTIGVESPVREGLQEKYGSNLFKCYRFSCQSFTAGFSAAHERDKHIGRHDRPFRCTDEACTGFLLGFISEKERDKHMKTTHAAADIQDGKFPTDEDVRNSVAEAHEVERESLESESSESSEFSESSEPQGALVPRQSPKPKRPRQTSFKCPHCPATYNRRYNLQSHLYTHTNERPYEQELEGQGQISNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWW8</accession>
    <name>A0A7D5YWW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase atnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atnJ_1</name>
        <name evidence="7" type="ORF">G6M90_00g082470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543476.1">
        <property type="nucleotide sequence ID" value="XM_014687990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWW8"/>
    <dbReference type="GeneID" id="26243653"/>
    <dbReference type="KEGG" id="mbrn:26243653"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="386" mass="41689" checksum="C1823E8EDD5B0FFB" modified="2021-02-10" version="1">MIPFPPSPLANANGWPSGFDFSEVNGHVESKYSKETGQWTPLRFVASPYMSIHGMAPALNYGQQAAEGLKAFRGPGDSVVSIFRPDRNALRMQHSADVASMPRVPVDMFLQACRSVVALNAAFVPPHESGAALYLRPQLYGSSPHLSLSAPNEYTFCVFAVPTGIAHGADPVKALIIDEFDRTAPNGAGHAKLGGNYAPVLRWSDEAKCKGYGITLHLDSARHEEVDEFSTCAFIGITAHDGGDGVAITVPESRCIIESITSDSILQIARSYGWKTIKRPIKYTELPDFTEVIAAGTAASLVPVRSITRQNRSVTLPAKPNVRVDAEGETVTYIPDSRNEAGPICLKLLAALREIQLGKVKDEFGWRCLVTEDDMQIDGGAVHNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY48</accession>
    <name>A0A7D5YY48_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g058270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544403.1">
        <property type="nucleotide sequence ID" value="XM_014688917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY48"/>
    <dbReference type="GeneID" id="26242815"/>
    <dbReference type="KEGG" id="mbrn:26242815"/>
    <dbReference type="OrthoDB" id="5241710at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="27653" checksum="729E840FFE1CC7F0" modified="2021-02-10" version="1">MASTTCSATSPLRILAALLFIPAFPLCLVHGILKHHPVPALGLLPQFFSIVAAAVVLGFHRKSDDENGEHSVEGTDQPPREYTLRDIIVHPVAVFCYDVALASGYMIVLVFTWITTEGPSGLSMLAAYATIPLLASLHGSLIHLFLALQAVYHGLAIHSLVQWVAWRAVPPSCPNCNVRLRTSFPDFPWLKYFRARRDGYAAIPAMEEDRYRDEADEENGIAPREPEAVDIISKNRKGKGTDFGDDSTWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYF7</accession>
    <name>A0A7D5YYF7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Filamentous growth regulator 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FGR27_1</name>
        <name evidence="7" type="ORF">G6M90_00g105550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541542.2">
        <property type="nucleotide sequence ID" value="XM_014686056.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYF7"/>
    <dbReference type="GeneID" id="26245792"/>
    <dbReference type="KEGG" id="mbrn:26245792"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="654"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="724" mass="78822" checksum="34831381659A6D9E" modified="2021-02-10" version="1">MRSQQRHDQMAARKRCSRACDMCKRRKERCDGRQPCGRCTERRVHNECRYETEHGGRAAKLHPARHRGGSISSSRGRSSVEPPSVTIDITDSSPAATPLDQSRLILDKKGRFMYLGDSANPSFLQSIRRLVRETQGPGPFVDDPLRPAMVEASPEGAPAWLDAGSDHKSPPALTEDEARHFARQFYLCTNGILDLYDKPVLLDQVPRALARDAVALPLAKPVVYLILALGAQSSPKDLGEVAESCFNYGRYLSARYLMDDPSTLAVEAYILIAMYLLAASRRNAAFMHLGFAVRAAYALGLHLKAVSMRFTADEFRRRERIWKSLRSIDILSSALLGRPPATKETRDTAAPDDYSACGDLLAIMEQVLTDVYEQRQISAATLNRVASRQREWAAVFTRGLAADNIEPGDGIEGGAPNMGLTHLKVVFHWTVMLLTRPFLSERVAAHARQAASSSSSSSPAWTPAESSRVLAHACVNSAIRTLALLEPLVEAWDTPTRLPFSVSCVVHSALVVGLAHFGDMHQIFPLDKSMYTARSLLQRFSSDAIAFRNCTIVQLLHEACQAYAEKRHAASMDMEGQLISSLFGQLHYTPPGTTGAEPGDHSALRVRGAPLLPLPLPPPHYPPPAAGDAISLIDKAFGDDAAADASWDSVSPAKTTVQPLSPSSTPATMPKHDDDAAALPLEVSSAFDGGNILGDEDIVNLESRDDLVSLYALIDTSGGYLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYK8</accession>
    <name>A0A7D5YYK8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">NBP35</name>
        <name evidence="12" type="ORF">G6M90_00g022300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548324.1">
        <property type="nucleotide sequence ID" value="XM_014692838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYK8"/>
    <dbReference type="GeneID" id="26237768"/>
    <dbReference type="KEGG" id="mbrn:26237768"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="36553" checksum="260A5D82EE92728E" modified="2021-02-10" version="1">MAPSLEEPEPVSDVLANPIKQKPQLVAPEPEHCPGPESQQAGQADSCAGCPNQAICASAPKGPDPDIPLISARLENVKHKILVLSGKGGVGKSTFTSLLAHAFATNPDSNVGVMDTDICGPSIPKMMGVEDETIHVSGSGWSPVWVMDNLGVMSIQFMLPNRDDAVIWRGPKKNGLIKQFLKDVEWGELDFLLVDTPPGTSDEHLSVNSFLKESGIDGAVVVTTPQEVSLLDVRKEIDFCRKAGIRILGLAENMSGFVCPNCKGESQIFRPTTGGGKGLAEEMGIPFLGAVPLDPRIRMACDYGESYFDSFPDSPACLAFKQVVKRVASQLGLDTTNVLPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ40</accession>
    <name>A0A7D5YZ40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylcholine-hydrolyzing phospholipase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g017090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548821.1">
        <property type="nucleotide sequence ID" value="XM_014693335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ40"/>
    <dbReference type="GeneID" id="26238265"/>
    <dbReference type="KEGG" id="mbrn:26238265"/>
    <dbReference type="OrthoDB" id="4330301at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22893">
        <property type="entry name" value="PlcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049756">
        <property type="entry name" value="PlcA-like_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49705" checksum="41F806B7C2AE114F" modified="2021-02-10" version="1">MDSQDTEEPVLSEETKELLANEPVGSCAQGATWISPYRILLPGEQQSPHAISLVDSRPHKPDFVFEFAEHGFLGNQIKLKYMKPRSDTDSTPDGKEVELRAYKLPLLKLGQGNVLKLTYGQISALAGDFYGTSNPISSGKSNAERKKFFFNAYHTLANNPQDQPKDARILLGYLQKEIDEVQKLYDAKKNPSEYYKEGTGLAGIEAIDKLIKGRHFPGYKDLLLINWDHFGDDARTAYTTGHSAAISWAASGAWTVDRLVEAYAINSFADHYLQDLFSAGHLRTPRRVLHGYEGVADALANMMHDEECALGLKVFNKHKSSWQAYGDKRLLDSVNKENLLQCQIAMLISAQEVYSAWKNRKEITSSDFEVWKTVPTKESAMGGQIVAPLFKLGPSGKWGDLERRSSLKNRREWKFTKQWTTAGTFLEKSTSGLWKYPMHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZA1</accession>
    <name>A0A7D5YZA1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g109690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987896.1">
        <property type="nucleotide sequence ID" value="XM_066131789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZA1"/>
    <dbReference type="GeneID" id="26243274"/>
    <dbReference type="KEGG" id="mbrn:26243274"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="238" mass="25979" checksum="62684A8ED11D642F" modified="2021-02-10" version="1">MSEENDKFPLHTAAREGNVLKAEGLLKTDPKLSRKKDDDGRYPIHWAASSNNLEIVTLLANQTSFDPDVQDDSGWTPLMISASVADSEAILRVLIQKGAEVNEKNSSGQTALHFVASKKNMDVARLLLESKPPASTRFRDRRGQYPIHRAAAVGSVPMVSLLLKNKSPLNPTDDEGFTPLHHAIAEGHGDVALALLKEGADFTLKNTEDVLALDLAPDKEVRRYIVQGAEREGIDLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0H9</accession>
    <name>A0A7D5Z0H9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g004420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542092.1">
        <property type="nucleotide sequence ID" value="XM_014686606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0H9"/>
    <dbReference type="GeneID" id="26245123"/>
    <dbReference type="KEGG" id="mbrn:26245123"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="343" mass="39158" checksum="C72A285F265FF6A5" modified="2021-02-10" version="1">MSGFFEQLPLPTIDRPFGVHLWPIFSKAWEAVVGYPAEEFKFVPFETPMSTLKSTSIFIVVYYMIIFGGRELMRSREPFKLKALFLIHNFYLTAISGILLVLFIEQLVPELYHNGVFHAICHYDGGWTQPMVVLYYLNYLTKYLELLDTVFLFLKKKPLTFLHCYHHGATALLCYTQLIGSTSVSWVPITLNLTVHVVMYWYYFQSARGIRIWWKEWVTRLQIIQFIIDLGFVYFASYTYFTSTYFPWLPNAGKCAGEEFAAFSGIAILSSYLVLFISFYFATYKKGGKSTTRKSLRRMSQAPLPDPLHVQAAAANAKSNGHSNGATTTGAKANGAATRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Y6</accession>
    <name>A0A7D5Z0Y6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tautomerase cis-CaaD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g107470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544095.1">
        <property type="nucleotide sequence ID" value="XM_014688609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Y6"/>
    <dbReference type="GeneID" id="26243482"/>
    <dbReference type="KEGG" id="mbrn:26243482"/>
    <dbReference type="OrthoDB" id="9981319at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028116">
        <property type="entry name" value="Cis-CaaD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14832">
        <property type="entry name" value="Tautomerase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase cis-CaaD-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="181" mass="20128" checksum="90E3E1A8A4A400F1" modified="2021-02-10" version="1">MPLYEVHHSHALTESQRVELAGAITRLHATTFTTPSIFVHVRFIHEDPSDGSYFIAGTPRHTSLNSIIAHVRTSPARTKADFDQLAQRIEEAWYHALGVGPASSDELVPSGAGEKKLIAVAFFPMLTARELGLTIPEAGKEVEWFKEQLPLIKKTADSQGGDFAHMLNEFKEREDLRKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z157</accession>
    <name>A0A7D5Z157_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g012150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549307.2">
        <property type="nucleotide sequence ID" value="XM_014693821.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z157"/>
    <dbReference type="GeneID" id="26238751"/>
    <dbReference type="KEGG" id="mbrn:26238751"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="883"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="953"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="201"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="920"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="619"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119428" checksum="0DFFE1F85E027BFE" modified="2021-02-10" version="1">MPPAAIKSGLPPRPGSRGPIASQLPALTAPRLHRIAHQVPGSSHLRSSFIANVSVDLIFLSSPVFVSFLRPTDDLSRCIEDTGQAQRYEDDSKMQPTEARGSRLRSRPFIATVVVLSALTAYSVLLQTHRHARPELRRDHQAALFQRAKEPECGDVHSAADQCAFVRKYCLDEDAGLLPYLEWYFCAFNGIKPIGFTLLVIWLGLLFTTIGIAASDFFSINLSTIAAILGLSESLAGVTFLAFGNGSPDVFSTFAAMSSNSPSMAVGELLGAACFITGVVAGSMALVREFRVDRKTYVRDIGFFIVAVAFSMAFLADGQLRFWECWAMVGYYAVYVVSVVGWHWYSTRRKRRLRREGEARSHYYSIPGHAGDELFGEPYRDEPENPQDDVGDDSRSGSARADISALERAPRIDIENRDQDSDRGGSLDDGSDEDHERMVAAEVSRSMRVLRTGRTKSINLTPIRPSLVGALEFRSALAQLQRESNLQLSDIPGRTYSDHPTGRDRRGTTSVVPDSGLWETASTPGVSSRERAFSYGARAPLSAPLPISEDEETSSESSANLSPGHATPAHGATPSTAYVVGGNLAPPPVGPSGAIETGRPSSGAHGHSKQPSGLRLIIPSRRSSYSDESSPSSPFPRYADSPSAMTPSQHLERTEFMLPPPVAPHRDGHFPDMSGSIIVRRRPIHWWPYALLPPPDVVLATLFPTLQAWGEKTIWDKFLSTISVPSIFLLVITLPVVESETNESSVDDLTVMESSGRRELGHETQSSPMEPQLIEPEGEWERYRRHSLSRSRRNSLATVEDRSPRLVVTLENEDTVVTPEVEATNGQTVAKPLSDMPSVSNANDELSTWNRWLVCVQFVTGPLFAVMILWANMAEDFSNPGKVLVKMILYTLLGSLILLAFLFLFTSDHKRPKYHFLLCFLGFIISIAWISTIAGEVVGVLKTFGVVLNISEALLGLTIFAAGNSVGDLVADITVARLGYPVMALSACFGGPMLNILLGIGIGGVLMMVQNANKKHAKHPERPIQYGPYSVKVGPTLMISSVTLLITLVLLLIIVPLNKWILSRKIGCGLIALWTLSTIANVVVEVTGVWQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z177</accession>
    <name>A0A7D5Z177_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547109.1">
        <property type="nucleotide sequence ID" value="XM_014691623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z177"/>
    <dbReference type="GeneID" id="26239672"/>
    <dbReference type="KEGG" id="mbrn:26239672"/>
    <dbReference type="OrthoDB" id="4204700at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="393" mass="44815" checksum="165B3066C0A320DC" modified="2021-02-10" version="1">MERPNDGEVHPPRMTRAEYTRNVRAAIEERRHKAMVNRQHYQPQIHEQIQRLFSDYEAPFYARMRGFGRTQTLALAESTVLGLAAGTDRNLSDTETQALTEHFLSSVHNMLAWKWVMTGLAGYMAYRGRQTMRFPFFKPVITGGRFNPATGGPQVRIMWHTARFAAYYGTFWLIGEPIFQGVNFLRQSYSMDKDPRLASLLRDGKKQTGEVLGAVQDSNSQQYGDAWRPESQQEYSSQINDGYQRPSQPTQAQEQQTWASYRRPEPAQQSPRGWDAADDIDDASPVAPSPRSQAEGAQSYGGSAWDRVRQQAQYSPRQTRRDQKSWEAPQGANSAWASDTDASAQYRGPRDDYSYSSTDEEKSTAKVQAQREFDALVERERRGADQERGSWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1B3</accession>
    <name>A0A7D5Z1B3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g071960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545865.2">
        <property type="nucleotide sequence ID" value="XM_014690379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1B3"/>
    <dbReference type="GeneID" id="26241898"/>
    <dbReference type="KEGG" id="mbrn:26241898"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="147"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="260"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40049" checksum="9EA5BD28995CC5EA" modified="2021-02-10" version="1">MTVEAKRDQQQDVPGRLIATAVMPSSTNRPRDHANSFVKRYRTEIAASSSSVFSTLAAFPLDSVKTRMQTYQYRGFIDCVKHTYRTEHLGGFFRGVMAPMASITLVRTVSFSIYQRAKYSYAAWVKKNMGYDILRHVNKPGTYPNLYSVACFGAAGATAGSVITFIACPFELTKLSAQVSVLLAERAGNCQKSRAVASSYQNKGTLRTMANIIKHRGILGLYTGLRLHLLRDTLGTSIYFMVYESGKQLGTTLAGDNPNSNKLAVVTAGGMCGLVSWALIYPIDSAKSIYQRNSLLHSRGEKVAPAPKIEFFKRHMYRGLGVSMSRSCLVNAIFFSSFEFVKKRIKTLDDDDNNNINKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1D8</accession>
    <name>A0A7D5Z1D8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TIP41-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Tiprl</name>
        <name evidence="3" type="ORF">G6M90_00g013620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549160.1">
        <property type="nucleotide sequence ID" value="XM_014693674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1D8"/>
    <dbReference type="GeneID" id="26238604"/>
    <dbReference type="KEGG" id="mbrn:26238604"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="36111" checksum="B69BAF5F4080CFC8" modified="2021-02-10" version="1">MQSRRLPPIPPGPTGRPPTLNHINDVNEPFPTRDALQAATKSHSQGNFTISARKLPISKAGAIDHLTEKIGIPMPEMIFGDNIVSILHRPSKWYFEFNTPDALDAVDKTDKHMLKVAYARDWESTREGTTQNIKEVVKPYDWSYSTTYAGTVGVAGQQQQQQQYDGPSSSEAASSPIVPQFQPTDKKIPVELLKRRDPILFFDEVVLYESELDDNGISMYSAKVRVHQQRMLILCRLFMRLDNVVVRLRDTRIYVDFETDEVMREYTAKEAKFDDVKRKLAMSGRLPDDITVVLRNPNELDPLLDIVQHQTEALCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1N9</accession>
    <name>A0A7D5Z1N9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-phytase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phyA_0</name>
        <name evidence="5" type="ORF">G6M90_00g053200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540446.1">
        <property type="nucleotide sequence ID" value="XM_014684960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1N9"/>
    <dbReference type="GeneID" id="26246808"/>
    <dbReference type="KEGG" id="mbrn:26246808"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="44"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="528" mass="57859" checksum="E096CC2FC026DB01" modified="2021-02-10" version="1">MSHSVAAVVTDIPSIYTSWGELSVYADNAEDAFGVQYVGLPDGCQVESVSTLQRHAERFPDSVDGAVTGGFAQKVANYSKANGGKEAFTGPLTFLNSHVYILNDTGLLTGRGASTEFSAGASFWNRYGRTLYNASVAQLQYSPTFASNGSARPKVTLRTTGQSRIENSLVNWSLGFFGPSFNSTPDPALTEWESPFRVVVIPEGGTENNTLASYDSCFNDNSDANANIASRLQDAYKRVYLRSALRRLQAYAPRGFTFDYQDLYAMQMTCAYEYSFIGMSDFCSLFTMEDWHGFENVLDLQYYYLYSYGNPTGRAQGIGYLQELMARIRHQFIASSNSSVNATLDDNPTTFPLGQQIYADFSHDDIIISVLTAMSLDYLKDAPTTSKFPPSADNHFTLSRLTPFGANLITEVVGCGASDPEPVESRRVAYAPGQYGYEASNSSYKFVRMRLNNGILPLNTIRGGQCGNATSGRLDGLCALGSFLESQESAFELSNYAFACFGNYTLANSTTGIDYDGTIVQGRDYTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2E1</accession>
    <name>A0A7D5Z2E1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine protease/ABC transporter B family protein tagD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagD</name>
        <name evidence="6" type="ORF">G6M90_00g033230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543252.1">
        <property type="nucleotide sequence ID" value="XM_014687766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2E1"/>
    <dbReference type="GeneID" id="26244053"/>
    <dbReference type="KEGG" id="mbrn:26244053"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04842">
        <property type="entry name" value="Peptidases_S8_Kp43_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034058">
        <property type="entry name" value="TagA/B/C/D_pept_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF5">
        <property type="entry name" value="PEPTIDASE S8 FAMILY WITH PROTEASE-ASSOCIATED DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="5">
        <location>
            <begin position="208"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="712" mass="76166" checksum="39CC903662034BEE" modified="2021-02-10" version="1">MHHIQINGNSRPDAGAASTAFLNTFAAPPPSVANSNYILIQTKGPLSAQQKQELRDKDVEILEYKGEDVYLCGYKPTTLEPLISNLRDFVTDAEVYHPDYVVEPDLKTGNDDDEAEVEVALHENIGDDDMSRVVNDIAAQADIPVANVELHDRKACVKVPKSKLAQLARIDEVKAINEVQTRRLFNNVACGILEAHTPVGTAKTTYKGKGQVVCVADTGFDTGSLTEYHEAFGDRVISLHARGRPAARGEPGNSDDPDGHGTHVCGSVLGKGDHAKEGEIEAPASEAKLVMQSLFDKFDKSEGPDPKSWNAGLGGIGNSYPDLFGGVFREGATIHTNSWGGPPQPYVERESARIDSYLWGNKDMTVLFAAGNSGADIDRNPGHVDPYSLSAQAVSKNVITVGASENRRPNVKSPVAGNKPLVYGAWRSKFPFGPISVDNVADNPEGMAAFSSRGPTRPDGRIKPDVVAPGTTILSARSSKIEPGHHGESWGRSSDARWMYLGGTSMATPLVAGCCAVIRGALVDNRVPRPSAALIKALLINGAVPMKGQYNQALPNGEFGPSVDAPNPNSGFGRVNLANSLRNIVANQESTVYGYQDVTGDQSLGMDGQHRGEHAVTVDIPEGSPAGLTLKVTLVWTDFPGERLQNDLDLIVAGAGVEKHGNQGDGSGFDRVNNVEQVVWKNVKPGSYTVTVRAFLTTKDPQPFALAWRAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2K4</accession>
    <name>A0A7D5Z2K4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">tsc10_1</name>
        <name evidence="13" type="ORF">G6M90_00g068250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540581.1">
        <property type="nucleotide sequence ID" value="XM_014685095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2K4"/>
    <dbReference type="GeneID" id="26246688"/>
    <dbReference type="KEGG" id="mbrn:26246688"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI70745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="346" mass="37625" checksum="625172830299C513" modified="2021-02-10" version="1">MPSTNAFQVQGRTAIITGGSSGLGLAVARQLAAKGANVVIVARDQARLLQGLDTVKKEASNPETQLFHQISADLTIPSEAVRVVDEVVSWNSGNPPDIVWCCAGTSHPTLFVDTPVTEFSTQMQNNYFTSLYMSHAILQCWLKSSRKSLTSNLPGSSDKSESRPNSTLQRHIIFTASFLAFYGIAGYSPYSPTKAALRSLADSLSQEMNLYSAAFPNEPRVRLHTIFPAGILTEGFEAENRIKSDLTKMLEEGDEPQTPEVIASRSIKGLESGQELITTDFQTGLVKRSMLGGSIRGGFVRGIGDWILTGLVFIIMTVVRGDMDNKVRKWGRQFGSTGMKEDKGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2U0</accession>
    <name>A0A7D5Z2U0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g065540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540220.1">
        <property type="nucleotide sequence ID" value="XM_014684734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2U0"/>
    <dbReference type="GeneID" id="26247029"/>
    <dbReference type="KEGG" id="mbrn:26247029"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="518" mass="54850" checksum="FA5BFE66FDB5134C" modified="2021-02-10" version="1">MSSTTTIDDKSLDDRSLGPDDDVFRLRPDRLSTAESLWVSESLSGVREAVFVAVVCMAQFCTQAAFMGTLVLLRTIGDSFGVSSPPRLAWLVGGYSLTVGTFILFSGRLGDVFGYKRVLLAGLAWFSLWSLVAGLSVYSSYTLAVLSRVLQGIGPAVCLPNALAILGAAYPPGHRKAMVFACFGAVAPVGGVVGGLCASLLALTWWPWALWAMAAWLAILTVAGFAAIPDMPPREEAPRTWRGWAETLDLGGALLGVVALVLFNFAWTQAPISGWATPTILVPLVLGLLLLGAFAVVEFRVSSKPLVPFDAVNADVAFVLAAVACGWASFGVWTLYLVQVLQDVRGLSPLLTTAWFLPVVFLGICAAVVTGKLLGPLQVRPPYVMAMALLAFTLGSVLTASTPADQSYWGQTFVSMLVMPFGMDMSFPAATLILSDAVPKRHQGVGASLVNTVVNYGIALGVGFAGTVEVQLHGHGDTPDDLMRGFRGALYMGVGLAGLGLAVSLWFVARERVLKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3H1</accession>
    <name>A0A7D5Z3H1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">txl1_1</name>
        <name evidence="5" type="ORF">G6M90_00g098150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546528.1">
        <property type="nucleotide sequence ID" value="XM_014691042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3H1"/>
    <dbReference type="GeneID" id="26240951"/>
    <dbReference type="KEGG" id="mbrn:26240951"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="130"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35205" checksum="04A90CF3A10ABE72" modified="2021-02-10" version="1">MSQAPVQISSKEQFDGILKSSKLVVADFFAVWCGPCQQIAPVYEALSKSLSRPQLLTFVKIDTEKVKALSEEYQITALPTFLLFQEGKVIQSVKGANPTELRRIIQKLASELESAGESSGTGTGSSGPWAGAEIPRGYSDISDQVEIRNCELSNADEDAGPVKVLFDVAKPSALSNDSNSVNVKDFVQSGADDQLLLFIPFQGSVKLHTLQITSLPPKDQDTVSRPVIVHLYINRPQHMDFSEADDTEPTQAITLTSKDWNAEGTANISLRFVKFQKTTTLILYVQKGEEGADAVRIDRIKIIGEAGTKREMGKLQKVGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3S2</accession>
    <name>A0A7D5Z3S2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein PET100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PET100</name>
        <name evidence="9" type="ORF">G6M90_00g013090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549214.1">
        <property type="nucleotide sequence ID" value="XM_014693728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3S2"/>
    <dbReference type="GeneID" id="26238658"/>
    <dbReference type="KEGG" id="mbrn:26238658"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="93" mass="11081" checksum="3569763637B5E85C" modified="2021-02-10" version="1">MGGLNLEVFKFGMYVMFPIGIMYYFGTNLDDRFSVPNFWPRPEECNKLPRDRDEVKAEYERIVARQRFRQAQLQEEQRQRALLQGNRNNGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z429</accession>
    <name>A0A7D5Z429_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CLA4</name>
        <name evidence="15" type="ORF">G6M90_00g013550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549166.1">
        <property type="nucleotide sequence ID" value="XM_014693680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z429"/>
    <dbReference type="GeneID" id="26238610"/>
    <dbReference type="KEGG" id="mbrn:26238610"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000910">
        <property type="term" value="P:negative regulation of sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035376">
        <property type="term" value="P:sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000356">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="521"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="809" mass="88646" checksum="4185ACA350D97A98" modified="2021-02-10" version="1">MANMAISPIRSTATSTYTGSTISLPIARQQSNNMDGMGGVAVKKEGWASVKESKNFIQPWKQKYLILRKESLDFHKTEGGKVSYTLYLKDVVNVGRVEAAGTIFEIKRKPDGASNSPGDDDGQTKTLHIKVKGDDELYEWIDFIYGACPGMGGVSNPTNFSHAVHVGFDPQTGEFVGLPPEWSKLLNSSAITKEDYERNPQAVFEVLDFYTDLAKRAENPNQYSSMTPTPPGGMQQKQIGAAAGAGIAPPRPAPPTPTQRNMSYGTTPPQSSNGQQRRPTLGDQQQQRQQMQNMAPNYVSQDALREEQRRKQMEAQRQREAEDRERRDIEAYNASLPKNKVPLAQQEIGGYGGTSGGSPHGDRFNPTRAAPPAPKLSGSPANGMRAQRPAPPPPSSTSSPRPPQAAQASSSRDPTGQSSRIPRNDGSPASRNPNGTQSQPRQPQPAQGVSRLPAPVKPLNVAPKPSQAHPAEGIKAAEAALTAKPSPSERKQDVRMSTMSENEVMAKLKEAVSKDDPNMSYSKQKKIGQGASGSVYVAKIKETAQGVAREVLRQQGARAQVAIKQMDLAHQPRKELIVNEIMVMKDSRHRNIVNFLDAFLRNSNQELWVVMEYMEGGALTDVIDNNPSISEEQISTICNETCHGLQHLHSQSIIHRDIKSDNVLLDARGNVKITDFGFCAKLTETKSKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIESEPPYLNEEPLKALYLIATNGTPRLKKPEKLSKELKAFLSVCLCVDVKSRASADELLAHDFLKYGCPLGSLAELLAFKKHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z486</accession>
    <name>A0A7D5Z486_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Branched-chain-amino-acid aminotransferase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g087420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542374.2">
        <property type="nucleotide sequence ID" value="XM_014686888.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z486"/>
    <dbReference type="GeneID" id="26244888"/>
    <dbReference type="KEGG" id="mbrn:26244888"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35208" checksum="380204694A7FC793" modified="2021-02-10" version="1">MAPRPIFTITHPRACSTAFERVFMTRRDELASQHEPFGDAYYFGPECVSERFKDDPARREESGVSDATFKSVLEGFDEVARQGKRVFIKDMAYYLFPAPGEKAQIAASLGGGEEPNNPTVIPFDMLKQFHFTFLIRHPRRSVPSYWRCCIPPLREVSGFDYFLPSEMGYEELVKFLDWAIERGLVDKDRLTVVDADDLLDNPEVMIRKYCERTGLAFDPSMLKWNDADQEHAKKLFAKWNGFHDDALSNRELKGRTHAQKTLTVEAENQDWEAKYGKEAQKIIRETVDANIPFYEYLKQYCIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4A6</accession>
    <name>A0A7D5Z4A6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI ethanolamine phosphate transferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">mcd-4</name>
        <name evidence="19" type="ORF">G6M90_00g007670</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986086.1">
        <property type="nucleotide sequence ID" value="XM_066129634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239187"/>
    <dbReference type="KEGG" id="mbrn:26239187"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1058"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1083"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1108"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1163"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1202"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1268"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="18">
        <location>
            <begin position="329"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="17">
        <location>
            <begin position="786"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1303"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="186"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1305"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI66089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1334" mass="147480" checksum="4639E4064489C191" modified="2021-02-10" version="1">MVLSDSEPDFDDVEAIGMPSSQELAGKAVASKRSRDRTANSTTRVTKPFQRTKSAKSGTGHLKLPAMARQILMEKSKNNTIEQAGAHGKHMDEPDKIALGKSYPNLSSSHEQGRLAGLSRNTGSSGKLYTQNIEKEHEPTFENGHEEPKSVEQLGQQETEPVIDAEEQFPTEYTNNMDEVSTQGRLGELMKKYDSLKTRHNELREVGMIAAERNFERLKQQSEQNTAASNKLIQSLKDELNVQSALAKQGEQARQQLERSETNVCDLESKICGLEASLSSARSEIKSLSAKLSASRAAEACVKNPGSALKPGVIGHKSAPSEVVRAAQAREDLYGDLTGLIVRGMKRGDGGSVFDCIQTGRNGTLHFKLSLDAGDASDSYDDVQFTYRPQLDTDRDGDGLRADKAFQSFPEPYPQNEKDLIPRPLAPFLRSRVLQEGTFGVSHTRVPTESRPGHVALIAGLYEDVSAVATGWKLNPVNFDSVFNRSRHTWSWGSPDILPMFEQGAVPGRVDTYMYEPEFEDFSQDALRLDYWVFDHVKHFFAAAATNQTLNKALRQDKIIFFLHLLGLDTTGHSYRPYSKEYLNNIKVVDQGVKEITELIQKFYADDRTAFVFTADHGMSDWGSHGDGHPDNTRTPFITWGSGVAAPEVHPGAIAPGHDMYSSDWGLDHVRRHDINQADIAALMSYLIGAEFPANSVGELPLSYLAADNSEKANASLVNAKGILEMYRVKESNKKTNELRFKAYHAFDGEGSSPENRTAAIANLIANGQYEEAIEESNTLIQVTLQGLRYLQTYDWLFLRALITMGYLGWMAYAITTVVDMFVVHEVIAAQRTPLGTATFLGVLFALYASFIISKSPLTYYLYAFFPVVFWEEVYAHRQSLYRGRLILFGHIQSAGGAASLFLHAVFYIAVIQSLAVGYIYREVLTGLFVLAAAWPFMYGLSFIQYHALLSMTWAASCLTMSTFTLLPAMKVESIGLVLAGGFAMFLVGFLYLILEDIGLADFTWAVNSNPSLKKTNKNIQRTLTGIQVGLILLSMLVTRSSALSLQAKRGLPVGNQVLGWAILIVSLLMPLLYRLQPNTHYLHRLVVIFLTCAPTFVILTISYEGLFYVAFSATLLVWVRLEYAAEIFYRKHQQSNGSLVQPNTLDQDLIQHRALRLSDARVALFFMVLLQSAFFSTGNVASVSSFSLDSVYRLIPVFDPFSQGALLILKLMIPFALISANLGVLNKRLGVAPSALFMVVMAISDILTLYFFWVVKDEGSWLEIGSTISHFAIASLLCVFVAGLEGVSTLFVSGIDVGDGQSELDPTTNQSGSTMTENGTPNGHSHSTKAKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4J1</accession>
    <name>A0A7D5Z4J1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS thioclapurine efflux transporter tcpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tcpA</name>
        <name evidence="9" type="ORF">G6M90_00g000330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543033.1">
        <property type="nucleotide sequence ID" value="XM_014687547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4J1"/>
    <dbReference type="GeneID" id="26244406"/>
    <dbReference type="KEGG" id="mbrn:26244406"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="545" mass="58215" checksum="D271EAC0D04BF91E" modified="2021-02-10" version="1">MSGSEAEKHGQTTPEASTAERDINVDGAERRKEYASGFKLVIIVASLCLSLFLCGLDQTVITTAVPIITNEFKAIEDVGWYTTAYLLTTSSFQIAYGKLYTTLSVKIVLLIALAIFELGSVICAAAPNSTALIVGRAIAGLGAAGIFPGSTLVLVHAAPMERRPALLGITTGMFGIASLCGPFIGGAFADGATWRWCFIINVPLGVITGVILTFFVTTPIDAQYANWTFKEKLAYARIPEILILVVALVCLVLGLQWGGAVYPWSDGRVVAMLVVFAVLTAIFLTIQIFLPKSRAIPTTIIQNRNIWFASIFALCSSGAMFIAVTYLPIYFQAIKNASALSSGVMVMPLILGFLVMSIISGIITNITGYYNPSMLLCTLLASVGAGLISTFDVDTPQPKWIGYQALLGFGIGFGLQQPIVCAQHVLAEGDVPFGVAFINMMQMLGGAIFVAVSQNVFLNRLATGVANVLPGFDTRKIIQGGLTDFKNLFDPDQLPKVIPVYAHVIGVVFLIVTGLCAATLLGAVGIQWRSVKMPKASQSREEQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z577</accession>
    <name>A0A7D5Z577_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987625.1">
        <property type="nucleotide sequence ID" value="XM_066131590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z577"/>
    <dbReference type="GeneID" id="90968180"/>
    <dbReference type="KEGG" id="mbrn:90968180"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12260" checksum="71931BA961FFCBAF" modified="2021-02-10" version="1">MAGVVKSALPSHLKPDAASGDDNGFERRHHGKTRSHMVSKGFFSALFSLRCPFYLEHSPCTARYPGSCVFAFATIHLLLLIGSIVLVLRRRNATQHIAFTAVVSWELPAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5Z5</accession>
    <name>A0A7D5Z5Z5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Aspg</name>
        <name evidence="10" type="ORF">G6M90_00g096500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546684.1">
        <property type="nucleotide sequence ID" value="XM_014691198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5Z5"/>
    <dbReference type="GeneID" id="26241107"/>
    <dbReference type="KEGG" id="mbrn:26241107"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="8">
        <location>
            <begin position="18"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="9">
        <location>
            <begin position="256"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="520" mass="54884" checksum="A809A68526F6A1A2" modified="2021-02-10" version="1">MSPSQTMDATAAGLPESRVLIIGTGGTICMQEGPDGLAPSEDFLETAMAPRPSFNDMSGLDVKLQAYQDGQLTSLASLRTPPTAYHRHIRYSVLEFTPLLDSSSISAADWASMAACVKENYHLFDGFVILHGTDSLAYTASALSFMMSNLGKPVILTGSQAPIFALQSDAVDNLLGSLILAGTFVIPEVGLFFHHKLYRGNRTTKVSSAAFEAFASPNCDPLAKVNGLGVTVNWPLVLRPTSIAEFQIQRHLDTAHVACVRVFPGIKPEMVDAVLRLPGLRGLILETFGMGNVPGGGGGRLTQVLEAAVRRGVVVVNVSQCVSGFVSPVYAPGTQLGRVGVIFGLDLTAEAALAKLSYLLALPGLAPADIPDRFARSLRGEMTEIAHPTFSHPSAPLEASAAARLTPAESAFAALGYAIRGDELPVVKQLLEGDGGRLLHTADYAGNTPCHLAAVNGSTDIMLELLHRGASVHERNRAGNSPLFLATLSGNEACAELLRSAGAHLSMDEIERGSLAKHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6E0</accession>
    <name>A0A7D5Z6E0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-hydroxybenzoate 6-hydroxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xlnD_1</name>
        <name evidence="7" type="ORF">G6M90_00g077980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI70106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="mbrn:26241340"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="449" mass="49207" checksum="979280668EF5634D" modified="2021-02-10" version="1">MSPAPTVLIIGCGVAGPVLGNLLIQKGYHPIVFEKVSELGDAGASLMLMSNGLKVLELVGVADNITAESCPIQRFIDSTSDGKLLGSSDLPSTFKDKYGHPLAGIKRTSINLMLKKTLLDRDIEVREGWELLDIEEKKDSVTAYFNHKRAVTASFLIGCDGIKSASRRALLRSKGIAEGLPSYTGLTQTAGISKVPDSLLTPAAMRNWYGDGTHVIAYPISKTHISWAITRRETNEAAETWRPYRQEELPEQTSQLCKLLEGWNSVLTDMINASERVIKFGLFDRQELEPSQWYSERCVLVGDAAHPTSPHLGQGANQALQVVSFLLLLLGIHDLLANLPSFVREDCFHLSQALPDLASVDTRFEKAVAALGPSLSDAIFKPYAEKRQPRTSHLVRGARAVGEQRTASGEEACVLRDGLITEKFADEALLASRMDELLREPFQRTQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6I8</accession>
    <name>A0A7D5Z6I8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g079360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987012.1">
        <property type="nucleotide sequence ID" value="XM_066131128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6I8"/>
    <dbReference type="GeneID" id="90968026"/>
    <dbReference type="KEGG" id="mbrn:90968026"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="157" mass="16950" checksum="155406745AB6606C" modified="2021-02-10" version="1">MSRPSESLMESPKIFAPDSSLAVRMNQVTPCGRLQWHSNVEKVGFCEPVGCSDELEGSVLENRWLLAGFSKAVLFQLTLEKLISGADVSMLGHGFLLAGFETWLDARSPEEAVENAEEVVGSTLENTLLAGPEDENASFGDAGLGEPIRCDELGSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z868</accession>
    <name>A0A7D5Z868_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545343.2">
        <property type="nucleotide sequence ID" value="XM_014689857.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z868"/>
    <dbReference type="GeneID" id="26241376"/>
    <dbReference type="KEGG" id="mbrn:26241376"/>
    <dbReference type="OrthoDB" id="5153480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18466" checksum="95432244691EAC59" modified="2021-02-10" version="1">MKMIVEILMIFLHPFRFPTFIAMLTMNSVFLGMMKAHNIPVNKNIVMTEVFAAVGAVVDILGLLKSCVVLGSDEYLSNLSLLCAGIVPRAVELFIMGCCIFIAVVYKAGAGDCDSYADTPFGDIKGEDGLTGVGTSCRMQAATFAVAIIAAFTSFCIIFVKAVLMVMRLGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8E2</accession>
    <name>A0A7D5Z8E2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g056640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544254.1">
        <property type="nucleotide sequence ID" value="XM_014688768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8E2"/>
    <dbReference type="GeneID" id="26242666"/>
    <dbReference type="KEGG" id="mbrn:26242666"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="102674" checksum="E153CD7258AE2F41" modified="2021-02-10" version="1">MLRRARTSAAQADDLHTYPLDWPQSQRWNPDYNVPRNSLEDDDSLAQSSTLSSTQPKGKTVYTEATVRRQDGQHSTAVHAQSRHQAAGLGSQLPDLSHWLKTLSEIYMNNLENRARWDPRWLSITRRERHEGLASSTITILDYMNDESVPLKTTTTEIAQLCVALQERPEACAVRVLMVNDLSRFVMGALGQLYAVDPEFWFDHLTNSGYAASDSQLKVSSAVWMNWAERETRFRHRSLPGIGQRTQWNTSSRTRGRNWGHIRWARLGLMHYLGKKGFNEDEIECRLGDGRWLVERDVFLDKYGFFMTPRRLLRHAQLAKRSSNKKPQDLYSRAKDSNIYRAYSTFDGLPKNVTAWKNRDLRVVAPEGASYWSGADEQGRRIDIIVFDPPRRMKDGITKDTIPSLTFMPRAIEVESYTDDDLWRIAGVEETFLDPPPPLISKKEIKKKRKEQLAQRRNEKRASGSKELRHNEATDEELGISVESGSESGFTSDDEYDQDYNNELRAEYKNPKPHSRDRDFARKYAMPTFNLVERLLTATPTQALLGDESPIPALLYRLVLDDFWQLLAEMRLQLDHLDNDLTATLYEQLVESIGNSTRQNLTWMRSTLQELHDWSNHLRKSGATLKATLDIQQEIEELNANVQDLQRRSEQTMNLLVSSMTLAQSSTVIEQTSGINKLTELAFFFIPVSFITSIFSMQVFELISAPPRIWTWGLSLSVVALTTYLIRISLRSPSFRVVLLHFRATIINRFSAPGAGTASRRLNTVGNRAIAKFIFFFTAVMTMFSMVVLPALFLLFLLMGGLWLGITGVALYFIVTRWPEAAVLVPCFISIPVALLGMATCWHWHEEISDGCLAAINWSVEWIKWVFPAQWTLDTVDDEDLAKEGINIYARQALVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8K0</accession>
    <name>A0A7D5Z8K0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase omega-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gto2_1</name>
        <name evidence="5" type="ORF">G6M90_00g112490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540317.1">
        <property type="nucleotide sequence ID" value="XM_014684831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8K0"/>
    <dbReference type="GeneID" id="26246911"/>
    <dbReference type="KEGG" id="mbrn:26246911"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF25">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="167"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="338" mass="38657" checksum="349ED7E9E11C0DBB" modified="2021-02-10" version="1">MATTIVGKNYHAGGRFVRPDSTFRNFISRDPESQFPAEAGRYALYVSPGCPWAHRTLIVRLLKGLESIIDVYQVHFVMGPDGWYFSGEGDSLPEDPLHGFKKLRELYLKADPSFVGRYTVPVLWDKKADVLVNNESSEIIRMLYSEFDHLVPENLREGNRPGGGLYPEHLRPQIDELNAWVYDTVNNGVYKTGFAKTQESYEENLGILFKSLDKLEETLGHGKQFLLGDDLTEADIRLYTTLARFDVAYHPVFLCDLKMIRHDYPRLHLWLRRLYWNKDEDGVFRGAFHRTTEPYIGKYGYGYAQSRHKIVFGDQGPLIVPAGPEIKMVSLDVGDEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAC4</accession>
    <name>A0A7D5ZAC4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g112330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540299.1">
        <property type="nucleotide sequence ID" value="XM_014684813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAC4"/>
    <dbReference type="GeneID" id="26246893"/>
    <dbReference type="KEGG" id="mbrn:26246893"/>
    <dbReference type="OrthoDB" id="4941274at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="133" mass="14957" checksum="69008181EA7A87D3" modified="2021-02-10" version="1">MASRPFATRDFDAGKFSSGFFFIIVPVVILLIAGVASSAVRYARRSRRRRATTADDAFTTDRPDHRPPSTIHPSLITQLQNLSPEPYALSSYPSQRTLDEIHEVVTPLQSVQLREPYERRHYAAERSPSGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBL5</accession>
    <name>A0A7D5ZBL5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 12A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HSPA12A</name>
        <name evidence="1" type="ORF">G6M90_00g094560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540821.1">
        <property type="nucleotide sequence ID" value="XM_014685335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBL5"/>
    <dbReference type="GeneID" id="26246434"/>
    <dbReference type="KEGG" id="mbrn:26246434"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="633" mass="70886" checksum="0FEF7BB29ECCCBE8" modified="2021-02-10" version="1">MERRPGVHSASETEEKPMKFLIAVDFGTTFSGVAYTLVNAGEPQKESLVTDWGEGLTGDKVPSILRYEHGATVNSVSWGFEADRRRKPGEKIHEWFKLGLCPEIEHSLALGSDLLRRYPSKTALPPLDPDQCKKLVIRYLQGVKSAIDRLFEQRVGEIYNLPREYIITVPAMWSHGAQEAMRECAAEAFLGDPSEKEELSMIAEPEAAGIYALSEMFDIGLEAGDTFVICDAGGGTVDLSSYEILSKDSYIALKRVAGTPGELCGSCFINRIFEDYLMSRSQLRHIDWNSKNGLQLLKSAVGDFERGIKPQFTGLNTSGALYLNTPFPSAGPRGAEFTLIEIPVDELRKQVFDPVVSKICRLVRHQVDSTIRPTRKVKKVLLAGGFGQNAYLKREIEKTVGETIKVQKIDNSRTAIVRGALMAGLAKIDNPQRHAAWQDGDKKNEQGRGRIFERNVPRVMVREAPCHYGTRIFRQEKSNASAQQNGINPNIGRSRPREVEVMRWFVNKGDEIYDGEPKHFELQYKANIALGEHPPKIICDVYSSKADNPPPRPHTSRHPVPGLEKPLATVCMDLDTIPEESLHCRVFRGRKYYDVAFDVYMTLNSAELTFVLGRGAERYKPAKVTVNETEWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZE93</accession>
    <name>A0A7D5ZE93_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine-rich zinc finger protein AZF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AZF1</name>
        <name evidence="8" type="ORF">G6M90_00g106570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539873.2">
        <property type="nucleotide sequence ID" value="XM_014684387.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZE93"/>
    <dbReference type="GeneID" id="26247312"/>
    <dbReference type="KEGG" id="mbrn:26247312"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002157">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF151">
        <property type="entry name" value="OOCYTE ZINC FINGER PROTEIN XLCOF7.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="60573" checksum="0645BE0E0135EEFF" modified="2021-02-10" version="1">MRFHHYSRALIVIIIFKYAIRPELSQLSWKLFSLLPKHIPSALYFLFVPTGLITLQDCPTIGSMALTASPAAPHNWGRWPQQLPHEFAMMEAPPFMPYDSRGNPAQMQRPIPPQYVVSPAYSSAPITSMTTSHYQAQNPFATYAPYQSPPPSTPVGSPFKPEYQDRSHPMSIATDPEAMRAVSSRRRSRQISDARLQSPARSDSDVSVARSVASNPTANSKTITYNETIDPADRINFETDVDELMKAIQAKEDERNDTPGQILTPAHTPKAEIVMDVHSPANSCHATHASTPVPEAKPKKKWVCDGPSCNKRFVQKTHLDIHRRTHTGLKPYVCTKDNCGLTFSQRGNLKTHMRRHTGEKPYSCSICGKTFAQRGNVRSHEETHKGLKPFICRLDDCNKSFSQLGNMKTHQNNFHKETLKNLTSMFFKFVQLGEVPEEHQDLFDYFKEHYKNSNKGIKGRGKARTVAARKPKGNSQQTATAAPMMANQFPQSHVANSAPAYVPRNFGMFETEADHATSGMLYEDEHARQMAFANRLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPL3</accession>
    <name>A0A7D5UPL3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">maoN_0</name>
        <name evidence="8" type="ORF">G6M90_00g000090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985643.1">
        <property type="nucleotide sequence ID" value="XM_066129476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPL3"/>
    <dbReference type="GeneID" id="26244427"/>
    <dbReference type="KEGG" id="mbrn:26244427"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="50"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="69"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="495" mass="54736" checksum="986C6038C25AE50E" modified="2021-02-10" version="1">MAQTKDGFTWTPSAGRSTGLPSISVVSPPVHLAAPKLLVYDVIVIGSGYAGLTAARDLAVQGKQTLLVEARDRFGGRSWNASINGSNYEMGGTWIHWHMPHIYREVSLYGLHNDWVVTQNPGSKEDYCTLTSGDDVRNMSHDMEDEITGKAWELFCNIDGDHLRQTWKYPFATGQSPELMAKWDQISCLDRLNEIRHLLTKEETAVLECFLQQMGGNSLDRMGLLDALRWWTLGSHEPNGLNNIALHTRLGSGNSRLHRRMFEHTLSTGNLSYTFNTPVCSIEESTDGIVSVKARGGQTFRAKAVISTIPLNVLSSITFSPPLPAVKLNAALEGSVNKCNKVHVDLKGPDFLSWSGMCNAGKGLISLFGDGLTRANDSHLVGFGPDPERPNGIKLDNIDAIKEAALHLLPKEKRDSVDIERIVSHDWNNDEFSKGTWCYLPPKVTTKHLEALQQPHGRVFFASGDWSDGWRGWIDGAVQSGMQVAHQVIQLQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQJ6</accession>
    <name>A0A7D5UQJ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maf-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g025170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548065.1">
        <property type="nucleotide sequence ID" value="XM_014692579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQJ6"/>
    <dbReference type="GeneID" id="26237509"/>
    <dbReference type="KEGG" id="mbrn:26237509"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29728" checksum="16B45CE71D5D4025" modified="2021-02-10" version="1">MPNGPPPGYDQATAERNTGPRSAGPIRKPVQPLDLPIIKHLNTKRVVLASASPRRKALLQQIGLNNLEITPSTKPEDVDKAVYGPYEYVAETARRKCLDVYTTCLETHLKSIPDPDVVIAADTIIATRDGRILEKPRSEAEHIRMLKHMRDTEMHRVLTAVTVLAPREDAQHPGYCITTHTEETKVYFFSEANGLPDDVIEAYVKTREGADKAGGYAIQGIGGMILAEKIEGSVDNVVGLPVRRCLAMAEKVVFQQDADEFDDGATDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQM0</accession>
    <name>A0A7D5UQM0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">WRAP73</name>
        <name evidence="2" type="ORF">G6M90_00g013050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549218.1">
        <property type="nucleotide sequence ID" value="XM_014693732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQM0"/>
    <dbReference type="GeneID" id="26238662"/>
    <dbReference type="KEGG" id="mbrn:26238662"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="525" mass="57081" checksum="B650DC1F14DC2C2F" modified="2021-02-10" version="1">MVTDPLYQASPLCKPSPNGRLVAVLSSSTIIVRSTETLQTIHAVKLSPELPRPISNLTWAPSSSKILVSAGDYIQVFAACDGSFQATIHGPAAPAGGKLPMIQFGSHDTEVLACAPFGIKFAVFDVAASKVVEISNPKFHHPTSASRGFSLRPDTGHLLMLTRVGGKDMVSIHHPLTRRVTRSWYPDTLDAQAVQWTPDGQWIVLWESPAQGSQLLVYTGDGQHFRTLDASSLRPDPTTEPESDMQPGIKSCQLSSNAELCATGDHSRGITVLQVGIWRSVMRLMHPTAIAPRETLQVWQEQVSVGVDGRNIHSFSRSTHTVSPPTFANGSNSNSTKQSTDVRGGCSSISFDASSTLLATRLDDCPCTIWIWDLAAAELRAALIFHLPVIFTWHPSIRETLLICSQDDREQCMSYVWDPLSHGPTPLYAEKYLPASKPASKMQATWLNNETESPELLITNSQHYVLLSLADADQEPSPWEAAVGGVELDGPSSGRDEAESLGSARPIVIADDASNLDDTFSFRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQQ8</accession>
    <name>A0A7D5UQQ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Short-chain dehydrogenase/reductase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RED2_0</name>
        <name evidence="15" type="ORF">G6M90_00g016460</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548883.1">
        <property type="nucleotide sequence ID" value="XM_014693397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQQ8"/>
    <dbReference type="GeneID" id="26238327"/>
    <dbReference type="KEGG" id="mbrn:26238327"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI63892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="38652" checksum="E939FD2655EB8CE3" modified="2021-02-10" version="1">MSLVKLSESAPVRGLQSLSAVIQSPYFSGPLLAALLYAPDHLKQQVLQHLPPNFNIDVAKNVLQVLLGLGVLKTINQGLSSMAANSWRVTAAKGWDWPGEIAVVTGGCSGIGYCIVKRLVARRVKVAILDVQDPPKDFAADPLVRFYKCDITSPDSVAKAADAIRKDLGHPSILVNNAGITRPLPILEMPQDFLHKIFDVNCLSHWTLVQQFLPHMIKVNKGHIMTVASMASFIALPRGADYSATKAAALSFHESLAIELKHVYKADSVLTSVAHPNFVRTPLVQDFGHHLEEGGIRMLTPDGVASVITDQIFRKRGAQLIIPDKQSSLTGIRGWPTWLKVILLDQLGSSSSKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URG0</accession>
    <name>A0A7D5URG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acu-15_1</name>
        <name evidence="5" type="ORF">G6M90_00g029050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541262.1">
        <property type="nucleotide sequence ID" value="XM_014685776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245897"/>
    <dbReference type="KEGG" id="mbrn:26245897"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1310" mass="140698" checksum="F8F288F1250AF111" modified="2021-02-10" version="1">MDGTAQLHFSQPEAANAGDSTLPGPPAPQSSVLHEDDGSFFVSPRSTTFVDFTWVPRGPGAPSPAGRSWSRSTSTWSARSSSRSTSCGQGYGSYSGHGCGSFSGRRARCATGPGGAASLSAASAAGGATCAAGGSLGAASAGVSSAVSADIGDVDMGGASLSPTSPARPRAANPAAPAGPAAARPHAPSSTHGPPAVEPGPAAAAACAPPPAPASTTSTSRSTPAPTIRTAAGAFAGAGADATAPPHQQHQQHQQQHQLEGTAGRCASGPQVASSSSQQHEACAGPPGAVVPTPSFRSSVPTAVPTFIPTLLPLSVPSSVPSSSLPTPIPTSSSGIHINTAVPSSVRLGSSSSPSSSSSCNSSPTGVASIHVSSAISSPTSISPRSTKPPASVAFNVKMPPRPAKRSADGSGASDDDASASSTAKLKLARSDRGPEDFSSVVKNRLQSYTRTGQACDRCKVRKIRCDALPEGCSHCINLNLDCYVTDRVTGRTERRGYMQQLEREKSRMMSHIRDLERLCAEKNVEVKPFQGRVRAQSPPDAAHEEDASNASANVAAASSNDGWSKFGSLWIKDSSTPDPTSSILRHNLPRNEWQTRPEQSRWGVGSDDAPLSSLKGMTLTLLGTTIETTSFDAPDVDEPPTAADPSVPLYNKSVQAFLRSAMRVNPAVQVELPTRENAFIYAEWYFITIASFMPLLHKPTFMKLLTRVYDEPGFKPTVPQLVMVHMVFAIILFQFGVRNSETLEQRNNFNDLSNKHYHFALSKMYEVFSSADFEALQGLVLIASHTRAFPKPGCGSIVASMALHRAIELNYHRRTKKPGEPTDLQNELRKRAWWNMMMVVVDINGKRGYPLPVSVQDFDVDFPEPIADELLSDEGVDTSRTVPCPYEIAIAAFKCIPIYMEMYANIFSVRRDESNYKNVLAVLEAQMKQWEADLPESMRLSPAKKHDHGMVGALFARTYMLEFRLHIRHPSLAMTTDAALIAENTKICEEAAREYLQTVEHLSRMKALDTTWHQMSLYCVAILSMLVPQWQRRFEITQDEVARLRDEMQRWMNIVREMSALLGCGIGMSTQIAQLINRTMSWIEHDMPQKDGKNPILAHVNVKQEHTLPSQGTVPLAPQEQQQHGHAVPFGAVAPQNQSFPSADTSQAEELTKNFYHANITAPAHATYPSLAYMDQQTQPNPQATASYQHDQTELYYPSSSAAAGHPGGPAQTATLAGYGSEAGQHICHQNSDMMWRSSWQNWSAAIAESQQRYGADSLMTLGDAETGRNSVITPIMAGNGMPHTGGELPMVPQPTSWPLIMFDQTPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US41</accession>
    <name>A0A7D5US41_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PAL1_0</name>
        <name evidence="4" type="ORF">G6M90_00g026430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985996.1">
        <property type="nucleotide sequence ID" value="XM_066129966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US41"/>
    <dbReference type="GeneID" id="26237386"/>
    <dbReference type="KEGG" id="mbrn:26237386"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="829" mass="89825" checksum="5440504990979D1E" modified="2021-02-10" version="1">MSLGAINDIYLSHRDAIAAKLKGHSANQAIDGKSLDLATVIAIARYGISSHLSDGSIEAVAKSAEMVQASIDKGEVVYGETRLSQTRTLNLTIIPGVNTGFGGSANTRTNQVEQLQSNLLRMLQYGVIAEERAVTAPESRHDTDLNDIISQSALPLDNPLASTSMPESWVRAAMLIRLNSLASGFSGIKETTIRTLHQMLEEGITPLVPVKGSISASGDLSPLSYIAGVVEGKPGLNVWTRNTKGERCLKRADVALAEKDIKPVSLGAKEGLALVNGTAVSCAVASLALHDAMGQATLSQILTAMSVEALLGTDESFDSFFGEVRPHPGQVETARNIHAFLSKSSLVQHSDTEEGELRQDRYSVRTASQWIGPVLEDLHLAHQQIGIEMNSVTDNPLIDPARDGKMLHGGNFQARAVTSAMEKTRQSLQTIGRMLFSQCTELINPATNRGLAPNLVAEEPSESFIWKGTDIMIAALQAELGFLANPVGSHVQTAEMSNQSINSLALISGRYTLEAVQTLSQLSAAHLVACCQALDLRAMSCKYLETMAPIFKDMTSEALSGYLLTPETGDVFLPATWAAFQKALDTYTHFDSPRRFAMTFESLQPLVLKHIRTTAEAVRALQAWTEKCCAVALDHFKMNREAYYANPEATPYIGSASSRMYKFVRHQLGVPFMSNKFISTPREEGGDFTWGEPDGDSNRGVTMGGMIAKVYESMRTGQLYHHVALCISDVHEYSSAANKDDEMQFSYALNKAGELTGWGGNSPGSLSGDEKNDATQAQNISSSATVVDDTLYLLETDAGTNQKLKEDMVYLTLHVESTRRQGQLSPHWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USC9</accession>
    <name>A0A7D5USC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenylcoumaran benzylic ether reductase PT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PCBER</name>
        <name evidence="4" type="ORF">G6M90_00g003410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541997.1">
        <property type="nucleotide sequence ID" value="XM_014686511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USC9"/>
    <dbReference type="GeneID" id="26245028"/>
    <dbReference type="KEGG" id="mbrn:26245028"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35182" checksum="FE583A0123FB48A3" modified="2021-02-10" version="1">MATVPSRILILGATGNIGQFITKNILHARPNNAKVTILTSENTVSSKAALINGWKDAGASVITGDITKAADVAAAYRGIDTVVSCVGRAVLDQQKELIRLAEESGTVQWFFPSEYGTDIEHNSKSPTERPHQMKLAIRKYIREHTKRLKVTYVVVGPYFEMWVDGGTCSDQIGGFKVEKGEAFLIGDGQGRIAFTSMQDTGKAVVAALRHPELSYGKALKISSFVVTPSQVLAEFEKQLGRKFAVKYIPLESLERTEAEFWEAGNPIATIATLRRIWAAGGTLYDKWDNDTIGLTSTDSLEGIIKSYLEEKGHLSGSQGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USW4</accession>
    <name>A0A7D5USW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANK3_0</name>
        <name evidence="4" type="ORF">G6M90_00g027400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547847.1">
        <property type="nucleotide sequence ID" value="XM_014692361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USW4"/>
    <dbReference type="GeneID" id="26237291"/>
    <dbReference type="KEGG" id="mbrn:26237291"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="41871" checksum="CC4F1F5D1E381DD6" modified="2021-02-10" version="1">MACGLPRGSWVRPRQGKSAHLACLPPEIVCMIVRQLPLAGDKAALYRTCAALHIALVEEELFRHPEPGDVNDILNWAVERACLRTARRAVAYGADAEASRRTDRETPLMTACRGGNLDMVRLLVEAGADANNRFSRDGSTPVVLSAGAAHDEAVVFLMARGGDPARRNRYGETALHLAARKDNLGLVRVLLASGRVDVNAASVTRSTPLLEAIQVGNMQMVEVLLEHGASEEIYELNGGFAFTKALRSRGTGLMKALLELRICPDVADARGRTALSWAAEYGHAMQVEMLLDSGARVDTQDVQGKTPLMYAAAEARIQVMETLLDRGASLAISDRYGMKAACHAVQSENWQSVGLILDRGEDVLCGAGRCARLLLQMAGQKENMGIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT25</accession>
    <name>A0A7D5UT25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutS 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">msh1</name>
        <name evidence="8" type="ORF">G6M90_00g012280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549294.1">
        <property type="nucleotide sequence ID" value="XM_014693808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT25"/>
    <dbReference type="GeneID" id="26238738"/>
    <dbReference type="KEGG" id="mbrn:26238738"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000042">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="900" mass="99111" checksum="1B7E3605ACC8D3B2" modified="2021-02-10" version="1">MRKFDNCVLLTRVGSFYELYFEHADEYAPLLNLKLASKKTNAGPVPMAGFPFFQLDRFLKILVQDLNRHVAIAEEFPNDAADKVKSGGLMHDRRVARIVTPGTLIDENFIDPYANNYVLAIHLAGSKEAPELKSAMVEDHGIRVSPPASPMLLGLAWLDLSTGHFFTQSADLASLPSILSRIGPREVVLDENIESQKDHDIFSILAEDRHLITYSPKGGLTDIGDWTPLLESPVPESARKTFTSEEVLAGGLVLNYVKGRLQGMTVRLLPPTRHESMQIMNIDKNSLRALEIKQTIRDGLFRGSLLHGIRRTVTKSGARLLNEWLSSPSTSLHVINTRQNLVARFIAAEHLRDSIIMLLRRSQDSQRLVQKFSLGRGDADDLLALAHTIRATEDIVILLQEAAASGSDAAQNECLSGLLSRIDLTQPLKLARKIKGAIDEEGIVHQHEVEDSEASQMLALAQDIVATEGSQEDASSLHKSKKKRPTSIKEYYAEDNDAWIMKPGASTNLKRLHAQLSSLLDEKIELSDSLREKLGASSLTLRWSTSLGHIAHIKGKDTKNLTNIRALSSSRSTTSFHLSEWTTLGQRLDQARFHIRREEQKVFQSLREQVVRNLVKLRGNAAVLDELDILTSFARLAVEQNLVRPKLNNSTTHTIIGGRHPTVEGGLVEQGRSFVRNDCLVGSQPDGLLWLITGPNMAGKSTFLRQNALITILAQIGCYVPASYAELGIVDAIFSRVGSADNLFRDQSTFMVEMLETAHILKQATPRSFVIMDEIGRGTTPEDGTAVSYACLHHLVTVNRCRTLFATHFHGVADLAASDGLCTVDGGGPVQLYCTDVEEDDQGGFVYVHKLRKGINRRSHALKVARLAGLPERAMDTATQVLEAQGAPSTFSTCAASGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT50</accession>
    <name>A0A7D5UT50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g013690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549153.1">
        <property type="nucleotide sequence ID" value="XM_014693667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT50"/>
    <dbReference type="GeneID" id="26238597"/>
    <dbReference type="KEGG" id="mbrn:26238597"/>
    <dbReference type="OrthoDB" id="3921745at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38134" checksum="569212ED6961D17B" modified="2021-02-10" version="1">MQAPLEQGGSALAGNSTKMGIKAITHVESYTPRKLSDDLPSIMLPKPMVHPHTPPESTTSSPRLKLEGPFPSISRDCSPLRSSISSLGSPRNHSLVRLPSLEEFDLGVEALARSYGPARPYTPPSPLRSLRRTSILPQPLPSLQAYVSQDHYAPYHMNDAYIHGVSALDGYPSPPPDGENRHINQKYTTEEGDFIIYAWHDKKLKWQRIKQDFAAMFGRTPERTVQGLQAWYYRMNQRIPLWDQDGWLIFDNEDDLEPKHISIKCRERDSQDKPMEPLGLAQRYPERAIHYSWVDPDLKRKCQDWAAKRAMQYRDRRERRKRKEQRRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT81</accession>
    <name>A0A7D5UT81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g000230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986068.1">
        <property type="nucleotide sequence ID" value="XM_066129482.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90967387"/>
    <dbReference type="KEGG" id="mbrn:90967387"/>
    <dbReference type="OrthoDB" id="4962751at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="71" mass="7747" checksum="28FF181ED12E3059" modified="2021-02-10" version="1">MSMSRGYISTFAADGRPLLIYYIHEALDQGTLSAEIRVLEEFAAAWTRGELDVNGKAPFADAQPCDIIVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTB1</accession>
    <name>A0A7D5UTB1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g016790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTB1"/>
    <dbReference type="GeneID" id="26238295"/>
    <dbReference type="KEGG" id="mbrn:26238295"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="364"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="821" mass="88930" checksum="156DF9F1971CB185" modified="2021-02-10" version="1">MPSFAGLTASGYGPGTSDASQDVGERGERGYRRRKLAAMAGNLYRSGQQAVTELRDSYVQSRGRGIDDFAMDQSTHIPGAFPDVAIASQGNEQMVLFPSYAKRHIKQDWTRMPRKQPVDQPELRNEEWWRQEWEKHEDEKAVVDVDVRGWIYSPHVGPMTRRNRILIGLARQLSGISAPKTDQGYGPASGEPKTQHQIHAEIHDEEKIAQKAAMIEKRGQEEKRVAYAGGYSEPSQDPNTLGVEAASRFGRRGSYTPDSAPPSPSMPARQPSGLGELTDAELAVANANLMARVAPFLTNPLVAMPITIFFYNDTKSQSKTILTDDAGHFNIRAALEFIPTHVRVLANEKLSTTQEVKITEPAGVSLISDIDDTIKRSNISAGAREIFRNTFVRDLDGMTIEGVREWYTDMHRLGVSMHYCSNSPWQLFPVLASFFKIAGLPAGSLHLKQYSGMLQGIFEPVAERKKSTLNRLVKDFPHRKFLLVGDSGEADLEVYTELALANPGRVLAIFIRDVTTPEAAGYFDAAFDFTHGKISSMTLDYSRSGSVKSASRQNSAPGAVGETQAASGPVMGTLIDFSDEPEEVKLDEAAALAQVKMANLGRPAGAATSALAGRKPPPPPRPAKPAALRSAPSHVNASNGGAKADMPPPKPKRPQGLGAAGLQPLTTILSAGQDGAQTTEDSSTPAPLEQEPAPPPLPRRRSGLKSISPRLFGRGASSSNTDVDFEPLPPSAAAPPPSFGFSYYRSGSRSGSSTPSGSPTLGAQGANKKLELWRRRLARAHEQLDHQGVALYTWRTGDDVVAEAVGIVTSAQEDMKRRQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTB8</accession>
    <name>A0A7D5UTB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Target of rapamycin complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LST8</name>
        <name evidence="5" type="ORF">G6M90_00g011380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549384.1">
        <property type="nucleotide sequence ID" value="XM_014693898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTB8"/>
    <dbReference type="GeneID" id="26238828"/>
    <dbReference type="KEGG" id="mbrn:26238828"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="71"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="319" mass="35582" checksum="A34D62F51CBA4572" modified="2021-02-10" version="1">MSVILCTAGYDHTIRFWEALSGICSRTIQHPDSQVNRLCISPDKRFLAAAGHHTVKLYDIKSTNPNPLLTFEGHTGNITGVAFHCEGKWMVTSSEDGTVKIWETRTGTIQRSYNHGHPANDVVIHPNQGEIISCDRAGAVRIWDLAENTCAHELVPEEDVPVSSVTVASDGTLLCAANTLGNVFVWTLKQTYDQTQIMPVTHFSAHKEYITRILLSPDVKKLATCSADHTAKIWEVNNTKPCDEGEKDPKPFPLEATLTGHQRWVWDCAFSADSAYLVTACSDHYARLWEVHSQQIIRQYNGHHRGAVCVALNDYSETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTI6</accession>
    <name>A0A7D5UTI6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyamine oxidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MPAO1</name>
        <name evidence="3" type="ORF">G6M90_00g047720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544889.1">
        <property type="nucleotide sequence ID" value="XM_014689403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTI6"/>
    <dbReference type="GeneID" id="26242230"/>
    <dbReference type="KEGG" id="mbrn:26242230"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028937029" evidence="1">
        <location>
            <begin position="23"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="528" mass="58849" checksum="D8A833CB226F44DB" modified="2021-02-10" version="1">MHLQHSTALFAIAAVAIPSAHAHVAKSAPKDATCRKTSVAILGGGMAGITAAQALSNNSITDFVIIEYNDRVGGRATQTNFGKKEDGSPYVVELGPNWIQGLGRPGGPENPIWTLAKKYNLKNTFSDYTSMLTYDETGYTDYSDILDEYDEAWTKASVRAGRMLAENAQDETTRAGLAMAGWNPKHTDMKRQAVEWWNWDWDAALTPEESSLIFGAASDNLTFHQFSDHNNLVIDPRGYRHIIEEESNTFLNKNDNRLLLKTQITNVTYSDDGVTIHNSDGSCISAAYAICTFSLGVLQNNAVAFEPQLPEWKRVAIQKFSMGTYTKIFMQFNETFWPTDSQYFLYASPTTRGYYPVWQSLSTEGFMPGSNIIFATVTEEGSYRVEQQTDEQTKDEALEVLRQMFPNVTVPEPLAFMYPRWTKAPWCFGSYSNWPIGTTLEMHQNLRANTGRLWFAGEATSAENFGFLHGAWFEGMEAGSQVAALLKGECAHVYNGAECGGRVHYETLRGTSPLENYNVLNGWASSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTJ9</accession>
    <name>A0A7D5UTJ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g026500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547937.1">
        <property type="nucleotide sequence ID" value="XM_014692451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTJ9"/>
    <dbReference type="GeneID" id="26237381"/>
    <dbReference type="KEGG" id="mbrn:26237381"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="57"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="487" mass="52549" checksum="86965C09FC4D9134" modified="2021-02-10" version="1">MSSVEATRNATDGRRPPSPIPLREGDTQGSSTPHSEWDDGAMANIATAEPVPPNGGYAWVCTFAVFLINANTWGINSSWAVIMAQYSTNKEAIQASHLEFGLVGGLSISQALLVSPLVTVVRRRIGARWTILIGTALIFVSLLTSSFASKIWHLVLAQGFCFGWGMGFAYVTASALLPPWFSSRRSLAVGVATAGSGIGGLVYSIVTDRVLHAWDLGWAYRVLAVSALSANLLAAFLLRDLNDKPRAAGPGEMRPSSFSPRDFGRVEVLLIVVWGVATELGYIILLYSLPIYAASIGLTPAQGSVANALLNLGLAVGRPPLGYFSDVFGRISVAGATTLLCAVFCFALWIPAQSFAPLLVFALVAGMLCGTFWCTITPVLAEVVGIAKFANTFGVICIGLVLPTTFAEPIAMKLVEGDSNSNTAFIHAQLFTGFMFLIGSVCVWLLRCWKIFSDVEKREESMTTLERQHRYWVSWITPQMMFSTQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTT0</accession>
    <name>A0A7D5UTT0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">vps74</name>
        <name evidence="9" type="ORF">G6M90_00g043030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547637.1">
        <property type="nucleotide sequence ID" value="XM_014692151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTT0"/>
    <dbReference type="GeneID" id="26240200"/>
    <dbReference type="KEGG" id="mbrn:26240200"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="39142" checksum="389BE54B1D1BE681" modified="2021-02-10" version="1">MSSSGLTRRRGAGGGGIANTEAEASNAASRTNSSHNVRDSGPETSYENSENGHKIAFDPRDISESAERSKQPKLTMMEEVLLLGLKDKQGYLSFWNDNISYALRGCIVLELAFRGRISMEKDPSRRRFPPADRNIEVIDDTLTGEVLLDEALKMMKQSEKMSVSSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKEELRRRVRNVLTQRTVVLSGNQFLPENLEFRYLRTVCMVCAAYAANVLENALSTLGHEARERAFAQTDELLADYSQWPFGKKATSNGIGANLPQAISEEISKAKDKELQLEVVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU78</accession>
    <name>A0A7D5UU78_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g047190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544840.1">
        <property type="nucleotide sequence ID" value="XM_014689354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU78"/>
    <dbReference type="GeneID" id="26242181"/>
    <dbReference type="KEGG" id="mbrn:26242181"/>
    <dbReference type="OrthoDB" id="5315820at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
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    </evidence>
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</entry>
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                <person name="Kortsinoglou A."/>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">4556</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="363" mass="41498" checksum="AA3FAB16EDB3720B" modified="2021-02-10" version="1">MNNLQISPFISSLPKVELHIHIEGTLRPPLRWTLAQRNNIPLRFKDQTYKTYEELLESYQVTYNHRPELGGRKDVPTFLEAYFAGCEVLLQEEDFYDLAMDYLKRCQEMKVRYVEPFFDIQAHTRRGVAAEAVLNGYLKAQRDGAERYGVKSQWIFCFLRDEPVEDGEAAYETALPWATCNGGLGLFHAVGLASNAYERPPILFKNAFARARADGLHLTTHCDFGQKDTHEHIRQAIFDVGVERIDHGLDALDRDELVEGLRTRGIGLTLCPHAYHRRTATEALFPKLRQLLDKGVKYCVNSDDPVYMHDVWIDGNQEKAYNYGGLSKAEMVQLGRNAVDMCWADEDVKKSIYAELDAIDTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW05</accession>
    <name>A0A7D5UW05_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PELO</name>
        <name evidence="13" type="ORF">G6M90_00g041080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547454.1">
        <property type="nucleotide sequence ID" value="XM_014691968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW05"/>
    <dbReference type="GeneID" id="26240017"/>
    <dbReference type="KEGG" id="mbrn:26240017"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="44975" checksum="48A40677844D7C11" modified="2021-02-10" version="1">MKLINKRVLKDVEEDQVSLLPEDPEDMWHAYNLIIPGDLVHAHALRKVVTVNSGTGAAAAERVHTDLTIKVKSTFFDPVISSLRVSGVVASENDHVPMGSHHTLDIEVNRSFTVIKPDGWDSVSKATLSQALSDDKNGAMAAVVMQEGLANICLITQFRTVVKTRVESVVPKKRDTAADQDAGLKRFFEKTLSSLLRAVDFSDSRPLLLASPGFVAQDFKEFIAKRGRDKSDKVLTAVSKQATVIHANSGHVYSLNEVLKSPEVIAKMKDMSYIKEAQYMDNFFDLLKMDDGRAWYGTKAVEKAVADGAVGPGGGVLLVNNSLFRSQELATRKKYVALVDKVKNDGGEARILSSDHESGQRLKMMGDIAATLNYPMMDLDDDGEDEEEPQAVVPERNHEDDYGMLDSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW96</accession>
    <name>A0A7D5UW96_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g046230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986466.1">
        <property type="nucleotide sequence ID" value="XM_066130410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW96"/>
    <dbReference type="GeneID" id="26242091"/>
    <dbReference type="KEGG" id="mbrn:26242091"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="481" mass="55407" checksum="5DDDA1E16EF1348F" modified="2021-02-10" version="1">MPASAIPHNLHDQLHPTPPRELGSDQSQSHSSGSNPSDSQSLQRALAGDDNALVPIHYPALKEAFLTSLEEQQDVIEATARHCLGVRNCHLGAREVWQSGSFNVVLPIHIAAGWSVFMRIPFPYRLGEDRCPGNVEEKLRTEIATYIWLRQNCPDIPIPELHAFGLPDGSAFSHPLRTPLWERTWWAFKRFACLLLGRPVPVHHVKRKTRHSINPGFLIISRARGEKLAWSWLDRFQDKAYRDRFFRSLARISLSLNSVPLARIGSLKLQPDASIALSNRPLSLYFQMLENEGIPTGIPRHLHDQEDGERQLAALTALRAIMHHFIRPEHRDGPFFLHLTDLHQQNIFVDQDWNIETIIDLEWAHTAPLEMQLPPYWLSSRVSVDSFDDQAAITDYEAVLEEYWAIYEAEERKRNDTVVQVPLQRDMWARGSFWYFHAVGIPKGMYTLFNRHIQPLFNKEHPDKQIFDTVFYCIGDLARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWK8</accession>
    <name>A0A7D5UWK8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor y region, transmembrane domain-and RING domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RMR2</name>
        <name evidence="5" type="ORF">G6M90_00g049600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545069.2">
        <property type="nucleotide sequence ID" value="XM_014689583.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWK8"/>
    <dbReference type="GeneID" id="26242410"/>
    <dbReference type="KEGG" id="mbrn:26242410"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="995" mass="105675" checksum="588ACFE23BA03CE6" modified="2021-02-10" version="1">MDPQPAAIPTTICSAADAAPSASNVGTGPCLSVTPSPSSKPPVLVLNLLVFHPHFAADVDTGRKPRCTTNVASLDLSPDDYDRSPSPIVDASTHPSICPLPIARQSGCSDLRRQPLEPAFARYVFWRRRGGNHPPNLRMTMADCLAAGLYGGSWLTLLAMFFAMSAVSAQGDITVVTSAQKDVPDWANPSALNMAITLQPGGKPSSSMYTVIPLTASVGLNGTGVIRGTINIMGHLKAANVSSYNDLSGGDTIAFLSCDKPASDGFIDPDKMLSRLMKASLKAIILYTIDQNICLISNEGTLPYTSILSMADSGEAGGVLSYLNGTQPVASADAQISGKAGQPSPNSGSGDGGGSNSAVAMSILYSITGIITLLFLVIIATGAIRAHRYPERYGPRGGLGGRPRQSRAKGLARAVLDTIPIVKFGNQEPAKPDPELELDGAMTDGHETTSHRAVTNTGESEPPEAKTAAAAAAALADKKDKSGQSSSEQTSKAPDAASAHAENEEGDEHIGCSICTEDFTVGEDVRVLPCNHQFHPHCVDPWLVNVSGTCPLCRLDLRPGQQGPNDQSSFNPEENLAPPLVLEGDDGDSSHATHSNRLSRLLDVNRLRQAGVEERIAALRQMRAHSANHGTREPETVEDRPQASRLTDKLKDKFLVFAIYADSYIFVFASAMLQHSIGLNASFKTCDSAILICLVCYVTTKFIYLFLVEKAHIIRGTPKKRIGSRLYMFNSLGMIAVYLAVVILNFVFRIAKLQDGECIIGMKSFAMIPLISFDAVVNVYLTIIFLIPLRNLYSYKNMPRTHTNMRLRTIAFKTFCGAVCTLLSSIVNLCALMSLDGEPGWVCLVSCNCDIIFSAAVIQWVTSKDNMGTSTASSTNGVINGREALGHESIRVLAPYAADFSTVSSPVDPSLVASARCSTQADMHAANATSAGGVIITTTIERETKLGGGSKSQGSPVGIPMGRGYQECYAGEDGCATFQDDPQGAYGSRVNITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWT2</accession>
    <name>A0A7D5UWT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">PAN2</name>
        <name evidence="13" type="ORF">G6M90_00g039600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986561.1">
        <property type="nucleotide sequence ID" value="XM_066130257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWT2"/>
    <dbReference type="GeneID" id="26239877"/>
    <dbReference type="KEGG" id="mbrn:26239877"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="487"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1055"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="855"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="857"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="964"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1017"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1111" mass="124557" checksum="57FC3A930F8F6CBB" modified="2021-02-10" version="1">MDGDWDEVARIPFPPPGVHAMPTPVTTMTFDTFQELLWTGNDYGRVTSFLGSELQRYTSFKAHLSTDGAVRQILVNDKGVIVLGSKDVHMAQRRGPPIWHIKHDDTKELRCMSFTSKGTAEIIVAGLQDTMLVIDLNKGEVVKQIATEHQYSIMKRGRYICAATKNGTVNLLDPVSFAVVKSWNAHSALINDMDAQHDFIVTCGYSLRQGQTYMLDPFLNVFDIKKMSSMPPIPFPAGAAYVRMHPRMLTTSIVVSQSGQMHVVDLMNPNTSNVRQANVLTYLSMFEIAPSGESMALTDAECYIHLWGSPSKLHFVDLPTPIEFASPEEHAPQIEWTPETPLNSVGLPYYRDVLASAWPDLVSDVGAPPIRFDPQFLVSLKPTEFGLYGRNTRGFRRNQVEDTRNSHKSANSGLKAPKFLSEKARESAISDSRTDDKTDDVPSPVAENEIESKKSDVPVMYRNVEIKYSKFGVDDFDFGFYNKTRYSGLEIHISNSYANSLLQIMHFTPLIRNLALQHAATACVSEICLLCELGFLFDMLQKADGSICQATNLLRTLSSHPQAGPLGLLEEDPHGSSLNVMLQGLTRFLLDKIVSDYKSMSPTSSAMEQILATSATSSIRCMNCRSEYTRPGSTYVNDLLYPPFKPPGRNAKMPRVTFSQVLKSSVERETTSKVLMLNTAITSHDHRMLWSTPGWLPEEIGIIVEQGQFFCYEGEDLKLHLQRGIHNITVYSLIGMATNIEGGQTQKPHLVSMVNVAHAEQEAPGQSQWHLFNDFLVRSVSTDEALTFNTSWKVPSVVSFQIKEANNKIDSTWKHQLDTSILYHDFPNPNSETKTYHILDPKTERPGPDTIVALDTEFVAIRQPEIEMNSDGERETIRPIVYALARTSVVRGQGENEGRPFIDDYILIQEPIVDYLTSYSGITREDLDPRISKHSLLPLKMAYKKLWILLNLGCKFLGHGLKQDFRVINIHVPKSQVIDTIDLFFLKSRLRKLSLAFLAWYLLKEDIQMETHDSIEDSRTALKLYRKYLEFEDAGILETMLQDIYRAGRDVNFKPPRKDDVGVQRTDTPPLPVDSSTPGPSTPVRKIIGMAPGSGFGGGTSWTPGKGSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWY3</accession>
    <name>A0A7D5UWY3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase aclL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aclL_1</name>
        <name evidence="9" type="ORF">G6M90_00g063890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986664.1">
        <property type="nucleotide sequence ID" value="XM_066130767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWY3"/>
    <dbReference type="GeneID" id="26244445"/>
    <dbReference type="KEGG" id="mbrn:26244445"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="514" mass="57382" checksum="162030B2309BEC04" modified="2021-02-10" version="1">MSPIQSISSAIANSLTLQLVVIAGLILAYPIGSIVHNIYFHPLSKFPGPKSWAATYLPYIRGIVTCNLVQSFAEIHQKYGDVVRVGPNEISIASEEAWREIYGHRPGHKEALKDATWYIAPSGAPQNVFTTPDPAVRARMRRCLSSSFTQSAISNQSSIIESYADLLITRLREMTSAPDSAQKGAVVNMGDWISFFTFDVIGDLALGETFGCLQNGEYHDWVRSLCTFLKGMTFAGVARIYPWVGSFVERFLIPRSVMDQQKQHVEFVSERVNRRLNLETTRPDFMTSFLKDNHDFENMSRGEIESNFAILIIAGSDTTTITMCGTLHCLTRNTDKLAVLEDTIRKRFQSEKDITVDGTKDIPYLDAVIEEGLRLCPAIPALLPRVVPAGGETYSGHYLPGGTKISVRPAILHTSARYFEAPHEFHPERWLPADQRPGQFASDNHAASRPFSVGPTGCAGKGLAWAELRLIIARLVWAFDMSVDPDHALDWTKWKARIVVEKGPQFLRLKQRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX00</accession>
    <name>A0A7D5UX00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540967.1">
        <property type="nucleotide sequence ID" value="XM_014685481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX00"/>
    <dbReference type="GeneID" id="26246273"/>
    <dbReference type="KEGG" id="mbrn:26246273"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="223" mass="25264" checksum="3AD978F823266279" modified="2021-02-10" version="1">MAIREAKYSDLREMAEAAAAAFQDEELFGELMHPRRKEYPQDFVAYFERRFLRHWNDPNCHLVVGLDKTTGKVVGCAQWERQGVQPASWIGSFMQSASRAYLQTLDYLWPNRAADPDKINILDETFPLFAHHWTEPRRQNWYLEFLCTHPGYQGQGLGKALVLWGVNRAKEDKICASVISAAGKEAFYGRYGFVEVGRANVGRLGACGIRGGAILFCEGHLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXI3</accession>
    <name>A0A7D5UXI3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unsaturated chondroitin disaccharide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ugl</name>
        <name evidence="4" type="ORF">G6M90_00g065970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540176.1">
        <property type="nucleotide sequence ID" value="XM_014684690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXI3"/>
    <dbReference type="GeneID" id="26246985"/>
    <dbReference type="KEGG" id="mbrn:26246985"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="487" mass="54772" checksum="A90362E607221CD3" modified="2021-02-10" version="1">MISQTTTTVENTVHESPLHGDTGTRNGRLSQLYTSNGVLKIWKTATEHLQRENPPQSFPETVPQTGPATGKYQYRDADFWTCGFFPGSLYCLLERSVKYPQQFLTDGALDGKGSQHGELLRQELPGVCRAWSEPLHEMANRTDTHDMGFIIEPALRRDFELTGDERSLVSIVRAAKSLASRYSETTRAIRSWDTFVNNRHQFTDKDKDFLVIIDSMCNLEILYYAGHHSRDQRLIDIATTHAHTVCKTHLRRENSSSGSKYGELSTWHVANMCPATGQVVRRFTAQGYSDTSTWARGQSWAVLGFAQTYMWTKDVVFLHTACGLAEHFMSRMESSPPCVEVSGKVGRYVPLWDFDAPVDENHVVRDSAAGVIAANGMLVISGALASLGHFVDAQRFLESSLAIVEDILALCYATDGLELVVEQREDGSARVVARSLEQEAEPFDALLRCATANYNRDWTDKYYNHGLVYGDYYLLEYGNRLLQLGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXJ7</accession>
    <name>A0A7D5UXJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosylmethionine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">spe2</name>
        <name evidence="14" type="ORF">G6M90_00g066130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540159.1">
        <property type="nucleotide sequence ID" value="XM_014684673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXJ7"/>
    <dbReference type="GeneID" id="26246968"/>
    <dbReference type="KEGG" id="mbrn:26246968"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI69237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="512" mass="55721" checksum="28DCCD3522039AF2" modified="2021-02-10" version="1">MVNLSVPKNYTFSPSSATPHLTINHNVAADLDSSNAFEGPEKLLEVWFASGPTALPSSAAPNGLKSVPADTWVGMLDMVNCKILSVLESDDVDAYLLSESSMFVFPHKLILKTCGTTTLLLGLQRLLHIAAVNAGFPFHNADSVNDVRAAATPYRVFYSRKNFLFPDEQKGPHRSWKQEVKYLDDTLEGGGSAYMVGKMNGDHWYLYITSPNQTLTPPLTPDSEINCQPTPAMTISSNGGSSAGGSYSQNDETLEILMTDLDPENAKQFFLSHASAVASDKLAAEAKNARKKAQDSVDCLTAATPEEIDVFGHCDEGDFETAKAQVTEELTTEGHALGSVVSESCGLNDVYPTSVYPDARVDSYLFSPCGFSANGVVPAPPSAEDDTAGATHYFTVHVTPEPGFSFASFETNVPGGQKGRTTAEIIEHVVNIFRPGRFSVTLFEAKGRGANPYGMGDGTFKSLSMQRLVDPVRGYRRVDRIVHDFEDYDLVFRFYEREDWLGDKAARVGEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXV7</accession>
    <name>A0A7D5UXV7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-coenzyme A thioesterase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Acot13_1</name>
        <name evidence="4" type="ORF">G6M90_00g052310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986730.1">
        <property type="nucleotide sequence ID" value="XM_066130535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXV7"/>
    <dbReference type="GeneID" id="26246723"/>
    <dbReference type="KEGG" id="mbrn:26246723"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="170" mass="18568" checksum="97F62407B28E31F1" modified="2021-02-10" version="1">MANQGSDATLNDAVGDKIRDWLQLTKNGHGPLKEGDWMVSVMPFLDVHSATASANTASITFTYTVQPQHCNRLHHLHGGATATLLDFCTSVPLSLVSRPGFWQYLGVSRCLTVSYLRPARAGDQVLIETEIVQVGKRLATLRGSIRRKEDGQLLCTAEHLKVNIDSAVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXW4</accession>
    <name>A0A7D5UXW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g064530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540091.1">
        <property type="nucleotide sequence ID" value="XM_014684605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXW4"/>
    <dbReference type="GeneID" id="26247127"/>
    <dbReference type="KEGG" id="mbrn:26247127"/>
    <dbReference type="OrthoDB" id="4939761at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12494" checksum="C796DBFB8CDF72C8" modified="2021-02-10" version="1">MLRSGSGPTTAGLAGIYTAATRDLIRGEASLAALSSCIYPLHWRKHLPYWVPDYSVAVANPVPRSFCADRALEYVPPETTPDDATSSLLRVRGYFIGRASAVGGRSGTRAQREARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY61</accession>
    <name>A0A7D5UY61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS8B</name>
        <name evidence="6" type="ORF">G6M90_00g034810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546876.1">
        <property type="nucleotide sequence ID" value="XM_014691390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY61"/>
    <dbReference type="GeneID" id="26239439"/>
    <dbReference type="KEGG" id="mbrn:26239439"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.70:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="206" mass="23283" checksum="46FCE95C9A4D1DDE" modified="2021-02-10" version="1">MGISRDSRHKRSASGAKRAFYRKKRAFEAGRQGANTRIGAKRIHTVRTRGGNHKYRALRLDSGNFAWASEGCTRKTRVIVVAYHPSNNELVRTNTLTRSAVVQVDAAPFRQWYEAHYGQSLGRRRQKAQAAKEGKVEEETKKSKAVEKKQAERFAATGKVDAVLEKQFEAGRLYAIISSRPGQSGRCDGYILEGEELAFYQRKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYM2</accession>
    <name>A0A7D5UYM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leucine aminopeptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ara-1</name>
        <name evidence="15" type="ORF">G6M90_00g074980</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986937.1">
        <property type="nucleotide sequence ID" value="XM_066131030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYM2"/>
    <dbReference type="GeneID" id="90967969"/>
    <dbReference type="KEGG" id="mbrn:90967969"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="14">
        <location>
            <begin position="464"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="264"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="560"/>
            <end position="562"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="606" mass="68449" checksum="1AF1FF4EEFCE74A5" modified="2021-02-10" version="1">MANRDPTTLSNYSAWRTKHTTVNFKLDFDRKLLKGAATLQLESQTDKGSNEVILDTRFINVQGVNVNAAEAKWELKPHSDPFGAPLHVSVPGGAAKGDVINVAIDLETTAKCTALQWLTPAQTSNKKHPYMFSQCQAINARSIFPCQDTPDVKSTFTFRLTSSLPVVASGVPVGDHTPAVGTEKTYEFEQKVPIPSYLFAVASGDIVSAKIGSRSVVVTGPNELDECRWELERDMDKFMEVAERLVFPYKWGEYNVLVLPPSFPYGGMENPIYTFATPTIISGDRQNVDVIAHELSHSWSGNLVSNASWEHFWLNEGWTVYLERRIQSAIHGEAEFDFSSIIGWKALEDAVELFGKDHEYTKLIISHKNVDPEDVYSTIAYEKGFHFLYYLDRLVGREAFDKFIPHYFAKWSGKSLDSFEFRDTFVDFFNHLGDEAIKQKIATIDWDGRFYTPGLPPKPDFDLTMVTACYELATKWKDASFEPKPEDVSSFTANQKIVFLDKLQESGPLSVERAQLLGKIYDFISSKNVELKSSYYRVALDANDPTCVYGVAELLGSVGRMKFVRPLFRGLNKVDRKLALETFKKNKEFYHPICRGMVEKDLGIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYM8</accession>
    <name>A0A7D5UYM8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beauvericin cluster-specific repressor BEA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BEA4_0</name>
        <name evidence="5" type="ORF">G6M90_00g055770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544171.2">
        <property type="nucleotide sequence ID" value="XM_014688685.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYM8"/>
    <dbReference type="GeneID" id="26242583"/>
    <dbReference type="KEGG" id="mbrn:26242583"/>
    <dbReference type="OrthoDB" id="4835445at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="685" mass="76135" checksum="A38C33DD24FDDA9D" modified="2021-02-10" version="1">MSQIKCDETRPSCRQCATRGQDCGGYRLHVRWSTKHESRPVHRAKHQSSPTWLYTARKSQPAQSRQLPAEPDATPEYPALSESESQLTSTTACSSSSADAPFDCPRDETRSVLDLGLLGLVSRLAWDPFNTGSSSSNGAIEGDWAHAGPTGFSGWDSDEPAPNNEDTALCDTEITWSTVSQESTAFSDDSGCFDTDQDARQSLVPISTVAHGPSMMVEYWFRDICPLWSQYDSESNFNRTIAAALWSNCEAVQLSLQAMSTAYLASKVPTMKDMSFSMMKAAAEVITADLHTINSHQLFDTVPVGLLYSLLCIGTSICWLNAGQLGLPFLSEAKALLYNINQHSDSLPADQRQLLQFFNKSWLYVEMLLSMVLSNCKSLQAVEGIGEADVRTCIGPDLPLVPVDDCPHPWTGICSTSLRLFTRTMKLCHRFRHAARTRATFASAHVTSAMRLMEQATSVEEQLLALDLSHLEAGGKTDDSKTPNQHLVRVGEAYRQAGLLQLYQTFPDLLVARYSPQTTAENNAHFPWHTWITPIALQLVTLLKGLPGYSGSKMTQPLLCITASSGLRLQRPLTQGLRQSQTADASDKHIEHHDMLQYIEIARENSEREHGEQVQDDAESTVLSARQFIRDRLKLLKTVLPSKPVSVAEELVEAIWRAYDGEHSLEYVTHWIDIMERENLKSNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ46</accession>
    <name>A0A7D5UZ46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lactoylglutathione lyase</fullName>
            <ecNumber evidence="3">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldoketomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ketone-aldehyde mutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylglyoxalase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">S-D-lactoylglutathione methylglyoxal lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">glo1_1</name>
        <name evidence="14" type="ORF">G6M90_00g055750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544169.2">
        <property type="nucleotide sequence ID" value="XM_014688683.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ46"/>
    <dbReference type="GeneID" id="26242581"/>
    <dbReference type="KEGG" id="mbrn:26242581"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="11"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="167"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI70031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="35573" checksum="75DD3F8E205EF7C4" modified="2021-02-10" version="1">MSPKTDLQSYKLNHGMIRVKDPKATIRFYGLLGLSVIQKLSFPENSFDLYFLGNDAPTAPSHGKFTFDRQGLIELTHNYGTEDEPGFTVSNGNSEPYLGFARFTISVNDVQAASKVLRDAGYSFRQDPCSSNTTSVIALDPDGYWVQLIEQHVPRLSPGTESYWSHRTNQIVLRVKDAEVSIRYYVETLGMSLVNSINNSVEGSTLYLLGYPSEGPFKDGQDVSAREGMLGLLWHHGTEKKDGFRYHNGNEHPQGFGHICVTVDDINAACERLESLGVAWKKRLTDGKMKNVAFLLDPDNYWVELVQNERFTGKANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZJ0</accession>
    <name>A0A7D5UZJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline ceramidase YPC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">YPC1</name>
        <name evidence="10" type="ORF">G6M90_00g077940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545311.1">
        <property type="nucleotide sequence ID" value="XM_014689825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZJ0"/>
    <dbReference type="GeneID" id="26241344"/>
    <dbReference type="KEGG" id="mbrn:26241344"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="299" mass="33246" checksum="4C60481C1B6C8AF9" modified="2021-02-10" version="1">MLRLHRHQIRLTPSLHNSAMNVQRAKPFWGAPTSNLNFCEEDYLVTRYIAEFINTLSSLVYVAYGIYGLAHGRRNGSRLVSYCGLIGVGVCSAGYHMTLKYHTQMSDELSMHLLSTPLLHRVLTFNKSERYTKTAGVVLFVLFTVVMAAHMLMDEFLLHATTFGFAVYMIGTSVMKLIPQQVPDPQTRSNIKKIARFGTISFGFGFFVWLIDEWACGMLNGARQSVGLPAAFFLELHGWWHIFTAIGGYIAVALVDEITTGQVTADPIPLLAWPVPLAAKYVLGSTKTEKANGVYGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZR8</accession>
    <name>A0A7D5UZR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540715.1">
        <property type="nucleotide sequence ID" value="XM_014685229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZR8"/>
    <dbReference type="GeneID" id="26246588"/>
    <dbReference type="KEGG" id="mbrn:26246588"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7342" checksum="4C5E6C30FDBAACEE" modified="2021-02-10" version="1">MGGQGREGGKKKPDKAPKKAQKDLDEDDMAFLEKKKQQQKELEAMKSKAGGKGPLNTGTQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0G4</accession>
    <name>A0A7D5V0G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4 gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tif471</name>
        <name evidence="10" type="ORF">G6M90_00g087990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542316.1">
        <property type="nucleotide sequence ID" value="XM_014686830.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244830"/>
    <dbReference type="KEGG" id="mbrn:26244830"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.970.30:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit eIF-4F, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="890"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1182"/>
        </location>
    </feature>
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            <begin position="1309"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="926"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1309"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1322"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1377"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1417"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1474" mass="157805" checksum="83626AD858273E8C" modified="2021-02-10" version="1">MTSPANQQNPIPAPNTSATTATSYASAAGAPKKAAQPSQVATGSQPPVVVGSSSASLAQNANTSSSSSVNGKPAVAPAVPAVARGSSTNGSGVDHSRKVSVTMAANGPNSYAANGGAKSGIQFGFDSPAMAHSTPHTANAAPIPIPGAGNHRVPSPAHSPSPIPQPSASGGRPPSGLPGSGQMTFGSLSSDGERHMRQGSVPPNPSAMGSQPGAHYRRESSHSVQGDNRANFPPQGGRGRGFNPHNQYNNQMGYPPNNQFRNGPGQGRGMPPSFQPQPRNMPYPNSPQPARSPALVPSMPNTPNMPPATMQPNMTMGTPPQYHYPPPMAPQHQQVQPPLPDVSDKLHFKSFKKSKARRDHAKSLQSGRLLDSIRELRGSDPSQPQRRFQQRPEQQWRDRDIGSSRSEVSGGDNYGYPPQQMDQYGRPMSMPYGYNNVPPYMGPPQTNPPAYNQQFAPPYAPQQSHSMSRTPSQPERPSSANQQGQPLVVGSSQPPNSQGKPGPNNFVKPRKSAAIQIKNAAGEVVDTSTFKQPVSPAPTGQPSKTPPVLASTPTPPPKSSTPAAHGRSESTATPKTAKEIQDELKEKIKQATQGAAANEAKNKEQAVATTTKAPADGSAEKDAAAASTATPKVEAPKETDKVEEPNKAEEEKPPAEPVADNGDTEEDEIERMIREMEEADAKREKEEEEHRKRAEAEKAEQKKKDEENRKSSAADEDRRLREQEREMERLEEEKERRQKEAEASGKTMSVAEALAAARSVRDGDAANVDSVTDKLSGMKIAEEKATGDAAGQKRSAKPAALNLTPLNTKPVDPPQPSAALQSLKSSRFLQVMDQEIYPTGINSPNPALNAAVAKKGKSFKYDAAFLLQFQKVFTEQPSVEFHQQVKSLIGDGDRSARAQTPRQPSNRGSNTFSMGTFNAPPGRTLPSGTTSEQRMAMSSGTMPRPPVGSIGSFRGPGGGFPGTAMSRTSSQSRAAGPNSPSGRQSSRSTRGSRRDFNTKEAQAAKTMPLTAGQEIKPIAVTSSGWKPTSVGNKPSASAPAANASGYLDPELVQRKVKAALNKMTPENFDRIADQILTIAGQSKDESDGRTLRQVIQLTFEKATDEAHWASMYAKFCKRMLENMSADVRDERIKDKNGNVVSGGNLFRKYLLNRCQEEFERGWSSNSPQLKEEEGAEDSSKKTLGDAAMLSDEYYEAAAAKRRGLGLVQFIGELYKLGMLTERIMHECVHKLVDYKGVPDEAEIESLSKLLRTIGANLDATEKGRPMMDAYFQRIQNMAELPELQSRMKFMLMDVLDLRRANWVSKEANKGPKTLDEVRAEAEAQAAKAQESARTNSRGGPGRPAMGRGDARNFSGGYVQQTSNQVGMDDLRRLKGSASRTASQNVTLGPSSMFASRSNSGRRLGPGGSLGRPGEDSGASSRTGTPPNRDSTSNTNAFSLLANMVDAEHPASPPSAGPSPLLAKAVPDSDKKESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0H2</accession>
    <name>A0A7D5V0H2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g083060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543528.1">
        <property type="nucleotide sequence ID" value="XM_014688042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0H2"/>
    <dbReference type="GeneID" id="26243705"/>
    <dbReference type="KEGG" id="mbrn:26243705"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF24">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="582" mass="64193" checksum="B44A7B029296735B" modified="2021-02-10" version="1">MSSKKNAAAIATAAGKVSRACDACRVRKVKCNGDQPCAQCAHLNLPCVFAPAPPKRKPGIRGRLVAQLRNKTPTSGPGSSQTVSPPSTALAGGSVSGGPSSAGSSPRSGVIPVTSIAGIVDNLGSSPPSEPAFTIGGCGFSADFFLGLLPEFEELVYPVNPVLTPAEIRTAIHNMHSNFEDAALVHAYASVTINLTKTSWTMNGIDIASQMTTLMQYCLWAHRKAEMAREGDGYNGGLQGEMPITVKRIMTCIWLEICLMAFKRFDRSYTILQEAISMVQMLNMHQYGQGDRRLTHTELARRQRMYWEVYIHERFLFIMSGFPCTMVPLRTGLPLHDETLAAHVAVGWNRLILLFQNMDDAFLSYWAAQQVPNPLLPEITSQWIESKQAQLDQDEADAVGDEKEMIVAGCGTLIELQHVDLFITRLWLRTLVWQLALSHGLLRSAPTQNTHEGLSLHFPAQRLSAQLRSLVSRLKSVSSVVFHGSGILQKLFEITSTVADVLALPRGIGQTEDESRARLEDFFYLVKFIFSFERTQKHQRDYLREKLEVLEKMYTVVDFRELAGASPSSASGDVYESIAKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V158</accession>
    <name>A0A7D5V158_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARE2</name>
        <name evidence="14" type="ORF">G6M90_00g070360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987035.1">
        <property type="nucleotide sequence ID" value="XM_066130932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V158"/>
    <dbReference type="GeneID" id="26246515"/>
    <dbReference type="KEGG" id="mbrn:26246515"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI70532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="672" mass="77305" checksum="36D6A139226D49AA" modified="2021-02-10" version="1">MRIGAMHSTVTQTPDERALSAPPTRHVDAVNGGPPDHHPRQTQPRSLGEALREAGVSLESSGPASETPSEEDYDENVRPAYAIGGQDQQHQQQQPQLLQRTKNERHIGRKGLVSAQIDSTIVRDDAGGVRIYPANDQALQELLRRTSETAKHPDKAAKLKRKFRDHFFTHQFSAFDPHNSAAANSPFHGFYTLFWLAVALFVLKISVNNWRAHGTPLGSNEIMKTMFHRDVIVLLLSDGIMCGLTGVSWLIQKLVYHRVVDWDRSGWIIQNIWQTLFITGIIAWTHVRDWPWTHTVFFVLHGIVMLMKQHSYAFYNGHLSTVYLERLFLLSKLKQLDLVHPSEEPSSAVPQVSSLSIDHLRVPPTAMERRHSLSQIPKTEETDIDRIAKAIASREPLNDEQIAVFERIIKWEVDALADELRGTASDPNKAYPNNLTFLGHYEWIPLPTLVYELEYPRSQEISWKYVAEKLVAMVGVLFVMNQVAQYSIYPVVMKTVQMKENGLPLAARFREFPLLLLDLIFPFMMEYLLVWYLIWETILNVLAELTYFADRSFYDAWWNSVSWDQFARDWNRPVHVFLLRHVYHSSISSMKVNKHTATLITFFLSACIHELVMWCLFNKLRGYLLVLQMCQLPLVRLSRTKWLKGQKTLGNLIFWLGIFTGPSLLCSLYLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V178</accession>
    <name>A0A7D5V178_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol phosphorylceramide synthase regulatory subunit kei1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kei1</name>
        <name evidence="2" type="ORF">G6M90_00g073350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987143.1">
        <property type="nucleotide sequence ID" value="XM_066130985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V178"/>
    <dbReference type="GeneID" id="90967944"/>
    <dbReference type="KEGG" id="mbrn:90967944"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28389" checksum="448F3145A6938291" modified="2021-02-10" version="1">MSKFTRLYLRAPRPQNLFGLVSLQTGTELISLALVFNKVSGVYGLLAILTGYQLSLLQLSTYVYSIGVLGLLVYLIPHIRRQSPFECLALAWLYILDTTINGAYTAAFGLDWYFANTTNNGSDSASISLPGIVAQGFDGLRRERAVHGKAVPQETATSMVLIVGLTLIRVYFSLVVMAFARQVLQKYMQLMILEGPGVDENEGPFAADLPDGDGRKGRLGRLMVSLGKRYWLDIPGSENWERSVHGKPHTSSGTLAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V180</accession>
    <name>A0A7D5V180_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Regulatory protein LEU3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LEU3_1</name>
        <name evidence="11" type="ORF">G6M90_00g091140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541766.1">
        <property type="nucleotide sequence ID" value="XM_014686280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V180"/>
    <dbReference type="GeneID" id="26245629"/>
    <dbReference type="KEGG" id="mbrn:26245629"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI72018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="711" mass="79768" checksum="D6BF43C5A8E6B052" modified="2021-02-10" version="1">MSGPKRKRSGPVKHESSPGSALEDDHGDHGDHDKKRQPGVKRACNECRQQKLRCDVVQEPFQSCSRCNRLKLECKIESNFKRVGKRSKHAEMEKEIERLRRNIDRAKAQGFVLEAGDDDDMNSPVAPSATPYTHTRNTSLMGSDEAVSSLLHLKRGGAYAAPHYSYELEGVRLTDDNVTHLFNEFFAYYHPFLPFLSPQQPPEQYNQQHPLLFWSIIAVAARRFSPRDCPNLLTNLSSPMTRFLWTTIGEVPSNYHVVKAMCLLCTWPLPTSTTTSDPTHILCGVMMKTATGIGLHRPNHIRDFSRVSVELNKEQLADRVATWAVCNIVAQNIGTGYGQPASTLYDWTLALRPGDDPALHLSTDLEARLQIERFCDKVSKEMYSNASDPRGVAGDEHRAMLMRVYRRDFGELQASVMSQQLGPIVNLHLRAAALHMRLAGFFDSSKTPGYMDDLMGLWRAASSFLDELLEVDKVTSPRERGRGTILLYATNYLQQMLVAAGFTLLKLMRSFFCKTIDFDRGRSLFHHSVKAIRATSVVHNDLQWRLAELMVQMWNGARLDNRNNAYNPDDDTAVQMDDSLQLKVRCRHSMSLVFDSVWRWREEYQSQGRGSLENTKHPTHPDSANESSASSSQLDSTLMPSHPLPPSSLLTANGALTPGATGLSAAATAPSTMIAGMPYDSNYDFFDPQHWMLDGLVDFNYGGFVPPLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1N0</accession>
    <name>A0A7D5V1N0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g090890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987443.1">
        <property type="nucleotide sequence ID" value="XM_066131386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1N0"/>
    <dbReference type="GeneID" id="90968108"/>
    <dbReference type="KEGG" id="mbrn:90968108"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="51" mass="6304" checksum="408F289C03D4A37B" modified="2021-02-10" version="1">MKDGCIYLIEYYRWQCRDELGQLQKQQTLEEEPRCRVGALRSFWSTYGYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Q3</accession>
    <name>A0A7D5V2Q3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lovastatin diketide synthase lovF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lovF</name>
        <name evidence="3" type="ORF">G6M90_00g080880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987364.1">
        <property type="nucleotide sequence ID" value="XM_066131164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Q3"/>
    <dbReference type="GeneID" id="26247758"/>
    <dbReference type="KEGG" id="mbrn:26247758"/>
    <dbReference type="OrthoDB" id="5414098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="223"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="370" mass="41446" checksum="A7A946061E2E38A8" modified="2021-02-10" version="1">MVPVRVDSIWIDCRNESLRSGEMCVRGECRLRGHRGASADVVGTANGSNTPLVYLEGLQTTFVDDNNVVSGNKPTKPRHLCTRIIWKPDLELMDQEQILRHCIHDRPPQGHDAVEGHRDMTLAIMAFVEEATEYVDDELPPARLEPHLQSFLGWISLEGAFFIHIGHNLLKVLNGEIDPVEVIFQHGLAEQYYGDVLASKHHSHAASTYFYLLCFKNPSIKILEVGAGTGRQTLPLLETMSGDGVKKWERYDYTDISPAFLSQASIKFQGYSSKMAFTIRNISKDLISQSFVAASYDLVVASHVLHATDILHESLTNVRKLLMPSGKLLLFETTKPDALIAFAFGLLKGWWSPLDHEERSLHSPCLSVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V307</accession>
    <name>A0A7D5V307_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbm42</name>
        <name evidence="5" type="ORF">G6M90_00g097850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546557.1">
        <property type="nucleotide sequence ID" value="XM_014691071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V307"/>
    <dbReference type="GeneID" id="26240980"/>
    <dbReference type="KEGG" id="mbrn:26240980"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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</entry>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
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            <end position="75"/>
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    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="QLI73093.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8458" checksum="CF249FF151F95702" modified="2021-02-10" version="1">MPHVASPVAMSSQRNDLRLFTSQDLYSLNANLSYKGNRPSTPVRRIQENDYTVPAPPPPSPVSFRADKWSMPSRK</sequence>
</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="QLI73654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="160" mass="17413" checksum="1070D10B24EF5539" modified="2021-02-10" version="1">MHSEIGVCEKQVVGTLKFRVRGSRREVSAAVDSYLPTSGFNHRLLKNPRYGHPSTQPVAGHVQDDVETWPSASSASNDGLFLAQTLRKRKILKPGLASVPTALALLVQQYVTITETTDLGTSSHLKASNDCALLTITSIIRWDMAPDQGGRHPHLMSPSN</sequence>
</entry>
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    <accession>A0A7D5V3J8</accession>
    <name>A0A7D5V3J8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Wdr5</name>
        <name evidence="10" type="ORF">G6M90_00g102430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
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        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-prop_WDR5-like"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="9">
        <location>
            <begin position="144"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="186"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="240"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
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            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="482" mass="52880" checksum="A9525FAC331B928D" modified="2021-02-10" version="1">MDSADHLTPGTPHIKRRKTHDDSSQRSSSPGTSPNARKHSEPRSREPRDPSQSRYDVTRSPSAAGSNKHYSSRSRSRRRSRSISSSGSSTRSESPPLSRTRSRRRSGSPTSSDRTRTESYSPRPRQPSPTREPSKPNYRPRLVLHGHTGPVSQVRISPNGKFIASASADGTLKLWDAVTGAHMDTLVGHMAGVSCIAWTPDSNTLASGSDDKAIRLWDRVTGRPKTTTRKSIAGQEMAALRGHHNYIHCLAFSPKGNILASGSYDEAVFLWDVRAGRLMRSLPAHSDPVSGIDFCRDGTLVVSCSTDGLIRVWDTSTGQCLRTLVHEDNPAVTNVCFSPNGRFVLAFNLDNCIRLWDYVAGTVKKTYQGHRNEKFAIGGCFGVLDGEPFIASASEDGDVILWNVKNKEILQRISTGHKGVCFWVDVNGEILASAGQDHTIRVYKHVREGGVTNGSTPSEVEMTSKLKGELPIRQEDIKLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3U0</accession>
    <name>A0A7D5V3U0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-aminocyclopropane-1-carboxylate synthase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Accs</name>
        <name evidence="4" type="ORF">G6M90_00g112480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540316.1">
        <property type="nucleotide sequence ID" value="XM_014684830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3U0"/>
    <dbReference type="GeneID" id="26246910"/>
    <dbReference type="KEGG" id="mbrn:26246910"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="63"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="431" mass="48077" checksum="F5284EDBC0D0C276" modified="2021-02-10" version="1">MALSTRAQDLSKPDPKFFFWEVLQNIWDPQNNPNGFVSLGVAENVLMHDMLSEHMHRNMALPNEDFTYGDGKKRLKSALARFLTRHFHPVVTVEPSHLTISNGCSSALEHTAWAFGNPGDVFLLGKPYYGTFVPDVTLRMGTQLAMVDFDDADPLGVDGVPKYEDAIRDAQAKGKRVAGLILAHPHNPLGRSYPRKVLLALMRLCQRHQVHLICDEIYALSTFTNTVDQGVEIAPFESVLSINTAGVIDPALVHVIWGISKDFGANGLRLGAIISQNNPGLHRALVPPSLYSSSSSISDHVVANILEDDAWIDGYILQNRTKLAENYEHVVQWARSNGIEYAAGVNAAFFLWVDLGSAYRERHIDDGRGIDQAVNDALLRQRVFLASGLQFGSERPGWFRIVFTQRRDHLDEGLRRILAAMNEVQTHGHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4G6</accession>
    <name>A0A7D5V4G6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">leu-5</name>
        <name evidence="15" type="ORF">G6M90_00g096710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546665.1">
        <property type="nucleotide sequence ID" value="XM_014691179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4G6"/>
    <dbReference type="GeneID" id="26241088"/>
    <dbReference type="KEGG" id="mbrn:26241088"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000003">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000338">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000034">
        <property type="entry name" value="Leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="90"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="14">
        <location>
            <begin position="275"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="484"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="689"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="785"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI73079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="961" mass="107094" checksum="EF83E20C6FDCA6D2" modified="2021-02-10" version="1">MQLVYAKQIGCKGACPALRVASRWPTRISRPSLTQLPVAPAASLQRWYAVNLNSLDGKWRKIWSEANEAGLEQPNNPKASDRKTNYVLPMFPYPSGSLHLGHLRVYSIADTVARYHRLKGDDVLLPMGWDAFGLPAENAALERGIDPAVWTRSNIKKMKEQLGSMNGSWDWSRELTACDPEFYKHTQKLFLMLHERGLAYQAEAEVNYDPVDKTVLANEQVDANGCSWRSGAKVEKRKLKQWFFRTSEYREALLRDLDELATNNAWPERVISQQKNWLGKSTGALVKFPIMVMGGVNVGSAIEVFTTRPDTLFGVQYVALAASHPVVAELAKKDAELQAFLDTLPGLPPDSKVGYLLPHLRAINPLAYHDETPDATKASLPIYVAPYVLGDYGEGAVMGVPGHDQRDHSFWKTHQEDQPVRIVLAASEDESTTTLPMSEPYLEHGVMTHHSGAFKGKHSVEAGQIMVRMLEAAHLAKSVEKWRLRDWLISRQRYWGTPIPIIHCASCGAVPVPDEDLPVRLPNVEKHWAKGKTGNALESSPEFVNTSCPKCKGPARRDTDTMDTFVDSSWYFARFIDPHNTQQLFSPKASKMLPVDTYIGGIEHAILHLLYARFVYKFLASTSLMPEYTDETASSAEPFKRLITQGMVHGRTFINPENGVFLKPDEVDLSDPSSPKIMATGVPAKVAFEKMSKSKHNGVDPTECIAKYGADATRAHMIFQAPVGDILNWDEAKISGVTRWLQRLHDQVVAVATADESRPAKDLLEEKFGRVGSMSSEELTQWDADAALWREVQHTIASVTQSYDEVYSLNTIVSDLMRLTNTLASSQANEAIKKHACNILTRLVAPITPAFADECWSVLHPSKGLIFDTCTFPSQDGTLDSAMLQPRQRSCAVQINGKMRGVVDIPTPPPELQGDALKDWVVREILKTKQGKERFGEGKYDLARAKRVIAVRGGKVMNFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5F4</accession>
    <name>A0A7D5V5F4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ube2z</name>
        <name evidence="3" type="ORF">G6M90_00g099090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546439.1">
        <property type="nucleotide sequence ID" value="XM_014690953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5F4"/>
    <dbReference type="GeneID" id="26240862"/>
    <dbReference type="KEGG" id="mbrn:26240862"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000126">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="287"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="441" mass="50607" checksum="AE0A5C236AFD0949" modified="2021-02-10" version="1">MDQSIIRISKELSDIQRGTDLAIAVACRDIDVRNVKALVMGPHETPYEFGFFEFAIRFSRDYPSKSPNVQCVTTNGGRCRLNPNIYANGKVCLSILGTWRGERGEEWSSAQGLESILLSIQSLLSANPYENEPGFEDANEESDKVYQKDYIQKIRHESLRISVIQRLENYLGLSPLTGSTLLLTKEDGGDDDEEVNVPFEPFRDICKRRFLWYYQSYLDAIEKGKSEVKLQDSFVRMPFEMPGNNCMEGKFNYPDLERRLNNVKTALDAEAAAWAAEGLTAVAKESTVAVNLYHQYEQVTAYFKRSDMPHDVTLDNDNPFVWIITYFGRPMTNLDGGLFRIRMNFSTRFPDEQPRVKFETKIFHHHVAPDGTACYVPNPLKREDVKSHIEAIISTLEEDEPAYDPRMIVNPEATKLFWGGGKDDKKQYNRRLRRSVQQSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5J7</accession>
    <name>A0A7D5V5J7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcriptional regulator NRG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NRG1</name>
        <name evidence="11" type="ORF">G6M90_00g109270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543927.1">
        <property type="nucleotide sequence ID" value="XM_014688441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5J7"/>
    <dbReference type="SMR" id="A0A7D5V5J7"/>
    <dbReference type="GeneID" id="26243314"/>
    <dbReference type="KEGG" id="mbrn:26243314"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001075">
        <property type="entry name" value="Zinc finger, C2H2-type/integrase, DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="300" mass="33176" checksum="4E2E210134F825EB" modified="2021-02-10" version="1">MEARNAAGRRVSLLNDDSIRYEKTQLHPHQQQQQHHHHIGFQPCRPYPSPRSNSSSPNTPELLRSDSYDSQMSNDPISPLTPSADYAYPRASLYAAELPSKRPAYVDSSRSTSYEDDTPAPSAPPPADRPGKRYPCRYRDSHGCKKTFTTSGHASRHSKIHTAEKAVQCTYPGCQKKFTRADNMKQHLETHYKDKSRSSASQRAQKAALAEARRNSSAGRSRSSTSTTTTSSVGSREAMQWESDVYASSAQPMASPSTSSWELRTHNLPLLNRPAIARSPSSGLDALAMAVACQEGSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6A3</accession>
    <name>A0A7D5V6A3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CAP2_1</name>
        <name evidence="5" type="ORF">G6M90_00g111410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543723.2">
        <property type="nucleotide sequence ID" value="XM_014688237.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6A3"/>
    <dbReference type="GeneID" id="26243110"/>
    <dbReference type="KEGG" id="mbrn:26243110"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP N-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="24952" checksum="81A1B0B56C13FE27" modified="2021-02-10" version="1">MDNNRAMHNLSTIIKRLEAVVSRLEDLSVFDGPILPSTLTDSNSEAIQAFDNFIDSSVKQYLLLSNRLGGLVAVQAAEVFKGFQEQRKFLCITTQTAKPDPATLETLLGPTKDAIVAVTDIQRKNRFDGMYVHLTAVADGIRMLAWVNIHSRPFVFVEESLGSAQFFGNKILKNQKEKDKLEVEWIKSYYQVCQGLASYVKLHFPTGITWNARGGLAEAVMGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKT2</accession>
    <name>A0A7D5YKT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g002840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542799.1">
        <property type="nucleotide sequence ID" value="XM_014687313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKT2"/>
    <dbReference type="GeneID" id="26244172"/>
    <dbReference type="KEGG" id="mbrn:26244172"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028974559" description="DUF7029 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="136"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="898" mass="96206" checksum="0108F042ECCC4E83" modified="2021-02-10" version="1">MLPVAFAAALFLGAAHPAVAYGPHFPLRNSTTNATETQAAPVVVWTTVTQIVTQTADAGCPANYALNRKPTATESPTATFVNSAPAATLSPNVHWSYDTKAIENVIPVEPKKGCELYYGASEPSKSGYYAFVTYFFKSPAVNIDHTDHLAAEYHEKNGMTVSFNNKEAFKHALDTWTMANGLLLIAYIPGCGDYAKGERCYFNVTAIEYKHDQLVIVAKGDSMHPDQVTNLGETEWGWWNANKDKAHGSASASGEAFAWGTSTASASPSSPTGASSGASKPLGQLECTAPADDAHGLPTACLGSNFDQLLDKQLGYTELSPEAKQFLDSLSSGSNVTGPANSTLSARALRMRRRSLAQRGFWSGVWNFFKTAFTTVYNAVASVISIGGAIDRDFSFKAPDPESSNTWAKTLLGDLTQTQSPWGEAILLKSLGSPNAVGDDGVLKYMNVYCVGCGASGHAQVAGRAQWSPLAGLQEGRLELQANMQFVLKLGIDAEFSLRQNLEYELFNYGLPALSFGVVTIGPYVSVGARVGLEAAARGKVLVGAEMGMQDSLVVIDLVNPGNNKNSGWDPYFKPVFEASGEVALSAELGLPVGLKCGLKISSWEKAVGVVDEPSIKGTAKVSGSVNLTDAGSIVGAFGDSDGCDGILTQISWRNRLWAGLVEPGDAPLLDTQDRALFRKCIGKDNKPARRELLDGPRPMRITATDKTARSSTGSKSMTYNVQGVPTELYNQTLNHRLLPLVNPTRSTRIVSCANGNLYAVQNDDQDNEYCFGLWDTTGQSDIVYDGVHRSLHYYSETMSRLGVSRLRASDAAQVPRTAVTVALVPFRNPDGDDFYVVVDHAEQVLFPIVCDFAGETASKLFVVSDPVAGPETLLRKDVLYSVTGGDVSKCHPLALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPG8</accession>
    <name>A0A7D5YPG8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter fmqE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fmqE</name>
        <name evidence="9" type="ORF">G6M90_00g041000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547447.1">
        <property type="nucleotide sequence ID" value="XM_014691961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPG8"/>
    <dbReference type="GeneID" id="26240010"/>
    <dbReference type="KEGG" id="mbrn:26240010"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="524" mass="56921" checksum="05CD2FE850AA7BBC" modified="2021-02-10" version="1">MDRRDSDRKAGGSVDYVERDGSANLTLWQSVKRYKNVVWCCIGLTTTILLFGYDYVIVGTTSAMPSFQRDFGRRLDGHWILPSLWLGLWTFASPGGSIIGAFCGGQIQDSVGRRASIAVGCFLSTIAVAICYVSYVPSDLDTRRGVFLAGKAFQGLAIGIVATTTQTYMSEVLPPSLRGPILAFFPMFTLLGQLIGAAVIFGCMEMPNGYVVCFASQWPFSIVPVIVAFFIPESPTYLVRKGKMAQALKSQQYLEPVGGDAQQTVDVIRRNIEHERRMTQATYIDCFKRANLRRTLIVMLAGALPQVFGLALLAKASYFAQVVGISANMSVVLLIVGIVCGLLANTASIWVLHHVGRRRLILCGLWGVSFLWLTMGISGIWDQQPTIIYTAFSMTAIIVVAGLSVWPASYAVGAETSSLHLRGKSQGIGWLTAGAAASLFGFFTPYLYNADAANLKSKIGFIFAGLCAAAGVLSYFYIPEMKGRTPAEIDGMFEAKLSAKEFKTWTAPSSNSSQTAGERKEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQ12</accession>
    <name>A0A7D5YQ12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GCS1_0</name>
        <name evidence="8" type="ORF">G6M90_00g006030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549903.1">
        <property type="nucleotide sequence ID" value="XM_014694417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQ12"/>
    <dbReference type="GeneID" id="26239347"/>
    <dbReference type="KEGG" id="mbrn:26239347"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="379" mass="41073" checksum="F6A10B6A07A64775" modified="2021-02-10" version="1">MASKAMWEVDPETRSKLAALQKESKNNICCDCSAPSPQWASPKFGVFICLSCAGVHRGLGVHISFVRSISMDAFKASEIERMRLGGNERWRTFFEEHEDTQMRGITWEDATIAERYSGDVGEEWKERLSCKVENREYVPGEKKPAAPAVKPASSPALGGQRAGSRTGTPLSNSTSRSESPGNRGAGGKVKVDDRYFSRLGAENASRPDDVPPSQGGKYAGFGNTPAPAKAGQAGIPNFDELQKDPMAALSKGFGWFTSTVSKTAKTVNDGYIQPTAKQLAEGDFAKQAQLTASQFAKQAQMAGKSAQEGFNRFVEGNDSNHRRDAPLDASRKDFWDDFSSLAEQKKQTSSSIGTSAMGMGKKGSSVAQPTKKADDWDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQA0</accession>
    <name>A0A7D5YQA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">naf1</name>
        <name evidence="11" type="ORF">G6M90_00g021110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548436.1">
        <property type="nucleotide sequence ID" value="XM_014692950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQA0"/>
    <dbReference type="GeneID" id="26237880"/>
    <dbReference type="KEGG" id="mbrn:26237880"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="311"/>
            <end position="561"/>
        </location>
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        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
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        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
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            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
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        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
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        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="59134" checksum="32747518934A8006" modified="2021-02-10" version="1">MSGFQIPGLGQAKPNETLPPLPADVLAAAASVDATEAPPASSEPHGTSQPKQSDNKTEGLNTTVATAALQATEEPDAMIIDQPDSPSSLTGALEAAIGGLDSTDNAPEQPQPQTNAVALQNDQSEHPEWEVDSSPYESSSESSSSDSSDEDSDNEGYELLGVEETARLLMEAEGGSDDEGDHGKGSSAARLRTKNEIAEEIVPKPDITITSEMKIEELGSIEHIVENTVLVKAITPGEYQVLDTGSALCTAERAVIGAVAETIGKVLQPMYTVYFSSEQEIKDLALEVGTKVFYPVDHASYVFTQPLRNAKGSDASNFHDEEVGDDEMEFSDDEKEAEYKRALKQKKKDKWRSKNEDKAGGAARGPHPLSQEVSADAGLNYDDDDGPYKPLARPPGFGDGLAPSESYEPAPRPGFRRGRGGDVRGRGSRGRGGAGRGGGRGGYGNTSRDGYSLPPQGGQQNSQQIPSQPATQQAAAPPVMPNFGFQLPAWPQSQAAPGQYPVPPPPPPPGWPAQGQGQAGAPNTIINPAFVAALMSQMQQQNGQHGWGAQQQPPPNGGQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRF9</accession>
    <name>A0A7D5YRF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547959.1">
        <property type="nucleotide sequence ID" value="XM_014692473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRF9"/>
    <dbReference type="GeneID" id="26237403"/>
    <dbReference type="KEGG" id="mbrn:26237403"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20085" checksum="73E2C8CF292B6B81" modified="2021-02-10" version="1">MPAPPALGALGMTFTAMRALQAISLITIIGLASNFISEMVTASYVPPPALVGTLVVACITAVYTVITYILYWDSMLPLLISTGADGLCLVATIVVACVVGKPVSYLSCPSLPDKGNTANFIHSLFLNLSRKNYFEWVDPDKATCFEIKAIWGLSICLCVLYFMSAVTSACLWKRIKGGSRPPPKDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSN7</accession>
    <name>A0A7D5YSN7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7600 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g033950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543322.2">
        <property type="nucleotide sequence ID" value="XM_014687836.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSN7"/>
    <dbReference type="GeneID" id="26244123"/>
    <dbReference type="KEGG" id="mbrn:26244123"/>
    <dbReference type="OrthoDB" id="4933705at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056021">
        <property type="entry name" value="DUF7600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24539">
        <property type="entry name" value="DUF7600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7600" evidence="1">
        <location>
            <begin position="324"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="705" mass="78675" checksum="ABB8C19DEC457240" modified="2021-02-10" version="1">MPPGGPLVPCALCSFTIGSYDTDPSGPVAWASQFRILYRGQADVQISGVGFHDPSDPSDFKTPLNRECRWDNRGPHAAESVRIGVLGQAPVNRLHGFPLHEACWSLLDQTSCPQPVSLGRLFGLFESLTFPLENVFWLLNSGFQDGAFLHKNHKDHYPWEGHFEYLSKDSELWHIASQDPCRVSEIKRLLTKQKGRPQWASRAIPYRQPAANDCFALLPETLCLTIASLLPTVDVLRARQASRGFVSVYYNKHFWRSRFSAAGERSWLFESQKWGPSLDWRSIYRRTTRRQCSPGLRNRARIMSLIQQVLEVLSSKWNEAPSSPTPYQGTAKWLEANANLNESILVAGLAKCCRQIQEIEASLPTAPYQLAISTTRLDNVQYIAGIRILRRSPDRDACLGFSTHGQEIYLDITEPILGFNLAAGATGIQAIQCVLKNGKTLGWIGNPSDLPKTQRLVVSTSIKSIKAGFDSFKMVSLAITEHSGPLSGEKTTGKVSLRHSAFWYPRMPYNGLNLNDDYFTAAESCNTRYRPLCWTEFGGRNGSHLRSVTGVSVTCFAAIRGIRFHYAIHTPQKMGRVGKYKAGPHDSVMHFSIDGPGGEIIDTIEVFLQLRSNDKMRMVYMGDVLVAFRASFIMSTNHKRTFHFGLEESKMGNQILKQLITVSPGSTMTGLYWSQYLGKITALGAMSAICQYPKRNPHDGSVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT25</accession>
    <name>A0A7D5YT25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inositol phosphorylceramide synthase catalytic subunit aur1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aur1</name>
        <name evidence="8" type="ORF">G6M90_00g043780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986568.1">
        <property type="nucleotide sequence ID" value="XM_066130333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT25"/>
    <dbReference type="GeneID" id="26240275"/>
    <dbReference type="KEGG" id="mbrn:26240275"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="212"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="52417" checksum="24120B268284D871" modified="2021-02-10" version="1">MKDLPGSVPGKPVLPSLWTENLTIAFLNRLPNRYHVGRRRARSKSKTMHPGAEDITVLRTSFNFWDGLRDLQRHRWRASDLQYIFLIGLTLFSLWIAPPAPALKFFALVAVSWIFLMPATRQFFLPAVTIWVWLVYFFCSRFIPYDYRPHIWVRVLPALENVLYGANLSNILSAHKHAILDILAWLPYGIIHFGAPAVCSLLMFIFAAPGTTPVFARTFGWMSILGVTIQLMFPCTPPWYENEHGLVPAMYGMEGSPAGLARVDKIFNIDLYTTNFTNAPLPFGAFPSLHGGYAVLEALFMSHCFPQFRMFFIGYVGWIWWSTMYLSHHYAIDLVGGGLIAVGFFYSVRARYLPQRQADKITRWEYEFVEIGDRHRLADEEYGHEYFGLGLLEQRRENSSDGWTLGGSSSCSSSSGTLSPTISEDTVPGMMVMDISSNGQIWDGNAPPRDVELSEVVVVRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT92</accession>
    <name>A0A7D5YT92_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g046780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="10"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544802.2">
        <property type="nucleotide sequence ID" value="XM_014689316.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT92"/>
    <dbReference type="GeneID" id="26242143"/>
    <dbReference type="KEGG" id="mbrn:26242143"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="11">
        <location>
            <begin position="376"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="453" mass="50256" checksum="8C2C70E7338AB1C7" modified="2021-02-10" version="1">MKQRAMKPNSWSKKLSWLGYVAGTLARNVPHEPSGKLPTLGWNSWNAYRCDINEQHFLDAAQALVDTGLRDAGYNYVNIDDCWSERTGRVNGHIAVNKTRFPDGIDGLANKIHDMKLKLGIYSTAGTLTCAGYPASLGYEDVDAADFAKWGVDSRTVVVVRHGLNRNSHSDNCYIPEQWQDEYIYCEEDGAQIGPNGTCSRSQNPRLAPDGYDWSKSKSAERFNRMRDALARQDREILYSLCIWGTADVTSWGHGTATSWRMSGDISPRWRSVTHILNMNSFKMGAVGFHAHNDADMLEVGNGDLTPAEARSHFALWAAMKSPLLIGTDLRRLGRRDLDLLANRRLLAFHQDAGHGGPAAPYKWGVNPDWTYNSTHPAEYWAGPSTGGHLVLMLNTLEATVRKTAAWWEIPGLGGGRYRVTEVWSGEDLGCLDEYAVDVASHDTAAVLVGPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTK3</accession>
    <name>A0A7D5YTK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g075290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI71340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545568.1">
        <property type="nucleotide sequence ID" value="XM_014690082.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26241601"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
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        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="235"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="398" mass="45374" checksum="395A67BEC65AFFB8" modified="2021-02-10" version="1">MPYSASTSWGKSSAPDPPRTIGATPGQWIQLTNEHVDHPHDIEAQVIIVTVYFFSSQHHEPNKTTAMSAQIPWRRCTHRRTCITISRPMILQPHGSYAFFPAHQWRAAHNQVSPRREARPPKSPLLNPPASTRPPPLDVPQRSASNSTLQYLFQLGKGYLKFYKDGLKAVMANRRLLKEKLERTPADDRPSVFKPHYVPKTFSRADWVMLWRVRHDMLRLPLFGLMLLVIGEFTALAVIYVDGVVPYTCRIPKQLYSGLQKAEGRRRAAFDELEAQYPHGVLSPRISAPVARKHVLRSLHLSGMMWDRLGFTPPGMWQIKGRLRMAFLEGDDKNLIEDGGPVGLETEELRIACAERGIDVLGKSETELRSWLGDWLRLTAAEDISERRRRMATLLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTV2</accession>
    <name>A0A7D5YTV2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ucp7</name>
        <name evidence="3" type="ORF">G6M90_00g020360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTV2"/>
    <dbReference type="GeneID" id="26237953"/>
    <dbReference type="KEGG" id="mbrn:26237953"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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            <begin position="756"/>
            <end position="798"/>
        </location>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
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            <begin position="57"/>
            <end position="68"/>
        </location>
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        </location>
    </feature>
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            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
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            <begin position="351"/>
            <end position="363"/>
        </location>
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            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
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        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="908" mass="97465" checksum="CF365178E4701E17" modified="2021-02-10" version="1">MDDLSGLDWSKPTGSQPKQPSMSIPMNSSYPTLRPTPPPAGSGRTTPSSTSQAPGVSSPLSKSAAKPAQDSFSNLMNFGPAKAKQNLSLAERQAQLEAEKRKKQDERKKQAEAQFGSAQQWDALGSRTFTPSPSIPPSAVSNGAANDDDDLFAAFNKDTKVDNSSHYPPPTSLRSTPLEEKKTLDLSNPSAWGASSIPTDINNDANANGFDDDDDPFGLNDLKPSGQSTAPAQATAGGDDDFLGDLAKPVEEVRMKQQQQQQSEPGKPIEDDDSTSSEDEHSRPRQQQRETRGDAGVSTALDRAVAQLVDYGFSPEDARRGLTESGAGLNVQAAANWLLDDAHRKAKENSQGRSSSTSSGRIASPHERQAGGFSGRGGDSDLTKSAATVGSSLFKTANSLWKSGQKKVQRAVADFQQDGGDPSQPRWMRDAQLGRGHDAGHASQDATDEAMALETGGRTKPSRTNSRPAADRRLGLQQSRTSSPSATSSGNQSRNSPVPRWQQTSSPSVSDARSRLNRMNIDDDDGFFVSANRRKKTTPAPTEEPRQPDDEPNLLFSTEAPKPSQPLPQHPAQRQTPPFMKQSQATPPASQRVTPKPARQAPPIGAAALQSSTRHRLEGSAHFKRGDYSMAHSSYSNSMSGIPDGHPLMIILLTNRALTAIKTGDTKQAVRDADEALKLIGPENGQGESIAVQGEDGKDETRNMKDLYGKALTRKAEALEQMEKWGDALNVWEQCVATGVGGVTATKGRQRCRDIAAPRPKAPAPKPAAKPRPKPSATAALSSGNSSEAVTRLREANAAAAREDDEKFALADQVDARVGAWRDGKRDNLRALIASLDQVLWENSGWKKVGLHELVVANKVKISYMKAIAKTHPDKLPQTASTEARLIAAMVFATLNESWDKFKAENGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU89</accession>
    <name>A0A7D5YU89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g055530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986755.1">
        <property type="nucleotide sequence ID" value="XM_066130604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU89"/>
    <dbReference type="GeneID" id="26242560"/>
    <dbReference type="KEGG" id="mbrn:26242560"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="3">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="64923" checksum="FF9F6681CCC33F61" modified="2021-02-10" version="1">MFIQGQSTFRHFIYTLLNIPKTAKPVLRLALNPTTPAHVCRDFFAIHLLFDRQHDPYLNAEALIHLWYSAKLPLALWRHIEVVMKRYYYDFDECFENAKRDQQSVCDDGVGYDVTYQMSWGGGQVKYVGNLFEHQWRLISKVLKPTEQMSTDQAAIVRVLDAEKSCEPLKVAASRMTPSRTAGLMKWRTDGLLLPFGHPTDGFDMPNPIFFQGDGCYPHGATAEPIAEWPMEFLDFQAGPLQNDVYGKLFYYLRDTLVRFQEESKRLSIMVGLTSVGMPMSLHRAPEPVMYDRIHMGDLWDFNPACNLTIAAGNLRHQDQNPFATMLAMCRLSVTNSDAGLQEEICGEGYQTFEPSSTILDDYAPPIKIEQGCETETVIRRRIGLLMWRNWDKFSERFMHDAKLFAFHLSTDSETDKETSVFKTGFLGMEYKDKNTITRRWPNRLVHSKSDEPSLRDFERHVGWFDTMPQRWLEWKRVADADDNEWEMARECVLESSWREMAEIQAKIIEEEAKSVDEQEDLEQRIRELLAEDAADREKSEKSAAAKTKAKASKRKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUF7</accession>
    <name>A0A7D5YUF7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septum-promoting GTP-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">spg1</name>
        <name evidence="7" type="ORF">G6M90_00g065480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540226.1">
        <property type="nucleotide sequence ID" value="XM_014684740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUF7"/>
    <dbReference type="GeneID" id="26247035"/>
    <dbReference type="KEGG" id="mbrn:26247035"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="290" mass="32425" checksum="B61A7BC3752E190F" modified="2021-02-10" version="1">MEMDHQVPATPVQGHDDTLGGIEGSPHIASNNGFHHQHNPSLDQSTPTSPRQDDDPAHRYTPPVSGPSHSRPASGLSNPTHQNHSDYRQGSNEPPNGRNHVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPILVGTKYDHFVNFPIQDQEEISNQARRFAKAMRASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEIENVGEPLLLYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUK3</accession>
    <name>A0A7D5YUK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g063790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542506.1">
        <property type="nucleotide sequence ID" value="XM_014687020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUK3"/>
    <dbReference type="GeneID" id="26244455"/>
    <dbReference type="KEGG" id="mbrn:26244455"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="315" mass="34886" checksum="F49B817A2F2C58EB" modified="2021-02-10" version="1">MLILIPGVTGNLGHHLAKAALHRGHQVRGMGRTPEKLDSNIRPQLESFVVERSGVDPGYDAACKDVDAIIVAWAPKAELIVDAQLKLLRAAERAGIKRFHASSWNLDWENFPLGEIETYDSMLIFATHARLTSTIRPTYSLVGILANTLFGVPGAGAMEGENAIWARNTDGTRLVRVMGDGNTRVNYCSESDAANFSVALITGDYGETGGFNRFCSDSFTFHELAAAFEKVRGGKVDVTQVMGLDECERQWRGMRAESLRKGELRQKWREFVGLQYAWYTFGGSSVSAFEPVDAAKCPDVRRTSIVDYIRENEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUZ5</accession>
    <name>A0A7D5YUZ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase I termination factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NSI1</name>
        <name evidence="7" type="ORF">G6M90_00g047130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544834.1">
        <property type="nucleotide sequence ID" value="XM_014689348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUZ5"/>
    <dbReference type="GeneID" id="26242175"/>
    <dbReference type="KEGG" id="mbrn:26242175"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="491"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="491"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="543"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="816"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="878"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="917" mass="103520" checksum="3F5682FFC2AA6499" modified="2021-02-10" version="1">MSDVDDYSITGSDNAADVGELPGVDEDFGAIEMFDSNAAPSTFSSQAPVAVMAEEAPLEASPRKSKRDKKGKRDRKRKSSQEDDVATSPIPEEEDSSRKQRKPKRKSTKGAEILDSQPTQHEPIEPSEDTPWGQLQEEEAAALSKTRRKRKLSDTVDGKGRKKKRSHDQEPESQDDEAGSSNLLRKRKEQRGDLESAIYEDDEPESDTQESPTVAHLRRRSQSREARSRENSVPSESQMDVDPGAEDRTKTAVAALAEADGDVERLAREALDEHHIGQQALEEGQNVDQDPDMSNQYPQEPLNASLESMVEAELPIAKSKKSRSTRKKAKPTYFEQDPIPDIVSEDEGNRNAWEESPSPSAAMPKARRVKRAAKKESRGRKPKRAKLSQSMRGGSADADDAFAQASGQPRNRLTGFKQGRFTDAELARIARAIESYRADHDITQQEVNELIHAPGGTTAGDTHAQLWSRIFAECPDRHRQKVINITRKKFHNFVARGTWTPDQETELAELIQRHGTKWSYLGSLINRHPEDLRDRYRNYIVCGQNQRKDTWDEEEEARLTQHIIESMIVIDQLRASQPSKTLLQKSYEELIDWQNISELMGRTRSRLQCITKWKSLNIRINGKDHLVSSQPDSQISFRLEKARRQISAMPVEERYRLVMAVHATAVGADVKIPWQRLVDKPFRNQWHRYTQMLLWRRLKQTVPNWETTSVRDCAQYLIDQYNQTGDLPEVPDELFDDADEMQYMQAMAPVPSAPGTQDDERGQVSTEFITESDAESDHAEPNGETTQLEGEEQPGEQAHEDVEMEIDPALADVAQPPKSTPTKKTSGKSPGSRKRTRKSAAAVEDSTEDTRQESQEPRQTEEDNADADVEQFHEKTTPRKLKSYRGKKAVRHSSPPASDADSVMDDMQDLPARVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWQ7</accession>
    <name>A0A7D5YWQ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EIF3F</name>
        <name evidence="7" type="ORF">G6M90_00g075410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545557.1">
        <property type="nucleotide sequence ID" value="XM_014690071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWQ7"/>
    <dbReference type="GeneID" id="26241590"/>
    <dbReference type="KEGG" id="mbrn:26241590"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="32"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="363" mass="39535" checksum="659E4DC3AFF5E201" modified="2021-02-10" version="1">MAAAATERFIHLARPLTHANAGLQSSIAPLVVNIQPQAILSVLDHAVRRDNRDNAQSTRVIGALVGTRSEDGTEVEVRSCFAIPHTEEEDQVEVDVEYQKNMLALTLKASPREALLGWYTTSPELNSFSALIQNFFASAETGTAPHPAVHMTISTEPGEDIQTRCYISAPVAVNAERAAESCLFIQVPHKILYGDSERVALEAVASAQNNENRTAPLASDIEGLGRSIEQTLNLLDRVSEWINGVLDEEEEPNTALGQYLMSALSLTPKVDASQIEHDFNNHIQDVLMVSYLANTIRTQIDLSQRLATANLVSSDKDGEGKGDGDKGGQRGNKRGGRGGARSGGQQREPREPREPREPREPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX27</accession>
    <name>A0A7D5YX27_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Scyllo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iolX</name>
        <name evidence="5" type="ORF">G6M90_00g040930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547440.1">
        <property type="nucleotide sequence ID" value="XM_014691954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX27"/>
    <dbReference type="GeneID" id="26240003"/>
    <dbReference type="KEGG" id="mbrn:26240003"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000132">
        <property type="entry name" value="NAD-binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="137"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="39090" checksum="40F223E2378F0803" modified="2021-02-10" version="1">MPPQKLKIGVAGLGRMGKRHALNFFQSVPRAELVAVSTPDAQEREWAEEHLAPSGVRVYDDYDDMLKQNGLEAVCIASATAVHAPQAIAAIAAGKHVLCEKPLATSAEVSQTVVDAAARRPDLKVMCGFSRRFDDSYRDAHAKMKAGLIGRPSVFRSQTCDMLDPSGFFVAYAQYSGGIFVDCSIHDIDLALWFFGEDGESKVKSVSAVGITAVEPDLRKYNDRDNAVGLIEFVDGRIVYLYCSRMMAAGQEDTTEIIGTKGKIGVNTIPTANLVRVYEPNGIRHEVPKTYWDRFKNAFNTEANEFTACCLDDTEVPVKLATAVAAVKIGAALQESMISGDKIWFNKEGERVERSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY24</accession>
    <name>A0A7D5YY24_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g024520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548130.1">
        <property type="nucleotide sequence ID" value="XM_014692644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY24"/>
    <dbReference type="GeneID" id="26237574"/>
    <dbReference type="KEGG" id="mbrn:26237574"/>
    <dbReference type="OrthoDB" id="5404004at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="550" mass="60135" checksum="74BC631C573E6457" modified="2021-02-10" version="1">MSEIPTPTGLADMERFTTPSGFQSYHRPMRRGTVLSRSPPDNQYPSATGLRGPHVNEADGTGIIPIGMALGSPTEERGSRGNVWQPRVETTVIAAREDSQDEQQTKDGLSRSKSRKWGIFGRSKSKRVKNNDRAMDSPDQLTSPSDTPTRGTPTSAASRGPRYTDLRDTNVSPRAKALGRSLTEPTGSESKWSPQVGSPQAKTQTTPDSTRTPNREPVSEGSNPIKQEPILDVEIPNITLDRYSVMFANLLERRSATSLLARRQVTQDKIRALREEVSSPGSQTEILRSGRKQSMDRDLPPIPSLRLEPLQTTRKYHQSSRSRSNTSPAIMGTPSKETFTDSHLRDGEKGKSPHIVRLASVKGSKPTVGSGISTQGDRPQLRSKFHIQSPTHQHSGSKSTIASSVDLSENDMEEGGLSPPPARSHSYKKGNPSQSDPSPLTLQKATRSTVYTTSTTGVQGSLSLSSLSGEEPDEDEDRAVQDAVEISIARQISVSREQRRMLGPLQMHPIEGRRIAETKSSTPRLVDPKLDPSSPSAGHRNSERVVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZF6</accession>
    <name>A0A7D5YZF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Extracellular serine carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g035600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546955.1">
        <property type="nucleotide sequence ID" value="XM_014691469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZF6"/>
    <dbReference type="GeneID" id="26239518"/>
    <dbReference type="KEGG" id="mbrn:26239518"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62671" checksum="C0D574EFC30CC3F3" modified="2021-02-10" version="1">MKIRNFYIALGLGASQVAALYPGGPRLPGSVRPVPVPDEDEEPAAAQISSNIKAYNMSVPIDHFHNETKYQPHSNGSFNLRYWADVSHYKKGGPVIILHSGEFSSEGRLPFLDHGIASILTQATGGVGIVLEHRYYGTSWPTDSATTENYRFLTTDQALADTAFFSKNLKIPGHEQLNLTAPETPHILYGGSYAGGFVAIARKLYPDVFWGAISSSGVTVAIDDYWQYHESTRYFAPGECSPTIQELTAIIDHALLKGSPRDQLEIKEIFGLRDLFDDEFASYLSDQLPSLQGTNWDPDLDDLGFGTFCAIITSDSLLFKSTEYLLERVRYHVEAAGHAHDSSKPLTMRMLNYIGYIKDNVKRDTRRCRGKSLRECLSVRYEKSTTEINENTWQRSWLYQTCTEWGYFMGGASTPKDRLPMISRALTAKFASYRCESFFNIKSRPNVGIINKHGGFNFSYPRVALIDGKQDPWRSAGVHAIGLPSRQSTPSEPFELIDWGVHHWDENGLDVKSLGPDRWSVRPKAIQDIQRDEVEIVKQWLREFEKPRHARSGLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZG0</accession>
    <name>A0A7D5YZG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540917.1">
        <property type="nucleotide sequence ID" value="XM_014685431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZG0"/>
    <dbReference type="GeneID" id="26246223"/>
    <dbReference type="KEGG" id="mbrn:26246223"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="243" mass="27408" checksum="92556E90775532A5" modified="2021-02-10" version="1">MAMLIDGRQHRFRLYLNGTASSSTPFLKPYLLFNESYIVAIFIACLFLRQQPSYAVYMAYRSVYLDKYRGSPSQRAHFAIFIPNSTNDNPDLDKEWKSKPCMGTVIHVVGEPLRNGYTLEFKRNECSTSPDIDELVFLGTVDSTHVHDPPNPDFVRETHPRQTLEQEIATIAHPPRGQDIRAPIDGVHTKRCQEWTMECLSRLEEQRLISSGAVDIAQSHRDAPNHGIFGQSGSSKTPGSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0C6</accession>
    <name>A0A7D5Z0C6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroxyacetone phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GNPAT</name>
        <name evidence="8" type="ORF">G6M90_00g073640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545701.1">
        <property type="nucleotide sequence ID" value="XM_014690215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0C6"/>
    <dbReference type="GeneID" id="26241734"/>
    <dbReference type="KEGG" id="mbrn:26241734"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="210"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="831" mass="92946" checksum="24F2C25B95827C76" modified="2021-02-10" version="1">MPPNDEPADAGSSSAPDLQILGDEITLQPSGYVEPEGGHEGKEEALLNQFASFRAEPLQFLREVSLYVSGQGWRAYNNVIGQPAFYSGFSENMKSMVLSAPLLQERITKLAEDRVAVEVKEGLINKDDKDFGVKCAQRRNALENGLQEVADKMTDDMICKMESKPFIRGAYYMATQLLTRAYHQGIHVSSEEVLRLRKVADFAAKKKQSIIFLPSHRSHVDYVSLQLICYRLGLTLPIVVAGDNLNIPLLGSFLQHAGAMWIRRSFGDDALYTTLVQSYIDTLLQEGYNFECFIEGGRSRTGKLLPPKFGILSFILDSILSGRVDDAIVCPVSTQYDKVIETEGYVTELLGVPKKKENLADFVSGGSSVLSLKLGRVDVRFHEPWSLRKFVDEQLSRLPSIPPGLDTEHHKPDVRAAREKILRTMGYKVLSDINAVSVVMPTALIGTVLLTLRGRGVGLQELIRRVEWLTARIRAKGGRVAHFGNAPTSEIINRGLDVLGKDLVGIVNGLAEPTFYAVDRFQLSFYRNMTIHLFIYEALVSAAMYMHVKRGGGPAMQDISYTELKDQVFFLSSLFRGEFIFGSDGLVTNLDNTLHGLEADHIVRLDRDQSGTVTTIGLSVEERKAGRENYDFYCFLIWPFIEASWLAAVSLMGLSPPPGSNGEIWVEQNKAQNSAQLLGKTLYHQGDLSYFEAVNKETLKNSYTRFEQDQIIHVVKSKDPKIPPRIQLDPEWRPSRDPKTGALVAAGKLWDFTEKIASSRREGKNRRDGATVSVRVLRLTDQLGAKLFAEAVDGEKQGKNKVPSRLSVEEQEAHKKDVRRRRKKLNQRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0X7</accession>
    <name>A0A7D5Z0X7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ADK1</name>
        <name evidence="9" type="ORF">G6M90_00g072740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545789.1">
        <property type="nucleotide sequence ID" value="XM_014690303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0X7"/>
    <dbReference type="GeneID" id="26241822"/>
    <dbReference type="KEGG" id="mbrn:26241822"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="269" mass="29750" checksum="9D2C247AFE715945" modified="2021-02-10" version="1">MGFVEDELKQLKEVIGNLDSRIKQLERRATGSSPSTEEIRMVIMGPPGAGKGTQAPKIKDRFSCCHLATGDMLRSQVAKKTPLGREAKKIMDQGGLVSDDIVIGMIKEELENNKECQGGFILDGFPRTVPQAEGLDSMLQERNQKLQHAVELQIDDSLLVARITGRLIHPASGRSYHSTFNPPKEPMKDDVTGEPLVQRSDDNADALKKRLVTYHKQTTPVVDYYQKTGIWKGIDASQQPGQVWKNMLDILQGNKSQGSGILSRIASKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Q9</accession>
    <name>A0A7D5Z1Q9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B-(1-6) glucan synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541818.1">
        <property type="nucleotide sequence ID" value="XM_014686332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Q9"/>
    <dbReference type="GeneID" id="26245286"/>
    <dbReference type="KEGG" id="mbrn:26245286"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028829079" description="B-(1-6) glucan synthase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38420" checksum="C9AC9875DE63196A" modified="2021-02-10" version="1">MHLTSLALAGLPALAAAAATPNCFPYGNAELPGDLTAPNVKLEDWWCPQSMAYGFQGFSYPLEDDNCNSYTNSFDRMNQDFARMKKDFGASIVRMYYPTCTQPGVFENAIRAAAKNNMALILQIWTNFGDGDVWKQSQQAIYDTLAKREFAAIAPYVVHSADWGSEPVGDGMDSGNFVNDLGAFRKRMNQHHVKAGISEDWDRPGSLRNGDGLTDLGRGIKSNSDYAHIHAMPFYHGNNPENQAWAYIQQATQWVLDHVKLPTMITESPWAWGKTDHNPGKTDVGVAQYTRYWKTFDDNCEWFKQKNVGWFLHAWQGEDKFDIVKPDGPGYVIPGWRPRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1U0</accession>
    <name>A0A7D5Z1U0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine adenosyltransferase 2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Mat2b</name>
        <name evidence="2" type="ORF">G6M90_00g003730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542027.1">
        <property type="nucleotide sequence ID" value="XM_014686541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1U0"/>
    <dbReference type="GeneID" id="26245058"/>
    <dbReference type="KEGG" id="mbrn:26245058"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003909">
        <property type="term" value="F:DNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="41582" checksum="BBD59B7A6744D60F" modified="2021-02-10" version="1">MASNGRRTALVTGATGLLGREITAAFRQSPKWNVKGTGYSRADGVDILKVNLENEDLNELNTVLDETQPHVIVHSAAQRFPDRVDKDPEGARSLNIAASRRLAQVALSRDILLIYISTDYVFPGIPGDAPYEADATPKPTNLYGQTKFDGERAILEEAAKVGKPGSAIVLRVPVLYGHAETPAESAVNVLMDSVWKAQTEGANIKMDHWAVRYPTNTEDIGRVCRGMFQVLIIPTTHMARFKQYTANFNCALYDLVHDPKRVFVNMATKEFFPDMAAKYLDANGPDHRKALPSILQFSSEDKMTKYEICQLFGKIMGLDTSNIEANTQGNDPNAAVQRPYDCHLSTKALQDLGIDISTCNFVDWWRREIRAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1U7</accession>
    <name>A0A7D5Z1U7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541369.1">
        <property type="nucleotide sequence ID" value="XM_014685883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1U7"/>
    <dbReference type="GeneID" id="26246004"/>
    <dbReference type="KEGG" id="mbrn:26246004"/>
    <dbReference type="OrthoDB" id="4941368at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="161" mass="17883" checksum="5464BA1AA95D93BA" modified="2021-02-10" version="1">MASSQDPRDHRPFVGMDDAPVRCQMESSFLSILHSAGLEEWAAQQSELANWQTGESASSSERTGSSSSASEGKSSRRAPSSRSAQKSSSAKQNGRSRKSKDHSDKSSRAGRSKHREQMTEEEKEEMRQRAASFVPDYSGYNTMDAELSIIGQQLKRMREHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z252</accession>
    <name>A0A7D5Z252_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">csn-6</name>
        <name evidence="4" type="ORF">G6M90_00g005730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549931.1">
        <property type="nucleotide sequence ID" value="XM_014694445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z252"/>
    <dbReference type="GeneID" id="26239375"/>
    <dbReference type="KEGG" id="mbrn:26239375"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="45845" checksum="964C1673695EED7F" modified="2021-02-10" version="1">MAAKSSNPLISNQKSSQVQAVLHPLVLLTISDYITRHTLRQQKGPIVGALLGQQNGREITIEHAFECHVREAPEVEGGYLLDASKFGARLEQMKTVHKERQLDFVGWYTLLPLTGPTPTILPIQTQILEGWNESAVLLGFHPDEVLNHSVGGKLPLTIYENNYEVDDQKAANPDGEDKRMEDGEAALKLKFSEVPYSVETDETEMISMNYVAAGGANATAASAPASTVAKDEKQAWSVASTSKGKRRLVEPKAYETDTIDETGVSHLTREEEEMVASLTTKANAIKMLHSRIRLLTAYLERLPPSDVSGEQPDSETMDTDHTIPSLPILRQIQALVNRFDLVIPSDEEAFNKELLQETNNANLVNLLSSVMQGVHGARDVGKKFHVVESAKKVGRKGRAEGYLASPGFNMPGTGDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2H7</accession>
    <name>A0A7D5Z2H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">liuE</name>
        <name evidence="8" type="ORF">G6M90_00g034900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546885.1">
        <property type="nucleotide sequence ID" value="XM_014691399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2H7"/>
    <dbReference type="GeneID" id="26239448"/>
    <dbReference type="KEGG" id="mbrn:26239448"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="370" mass="39439" checksum="AEEDAC53CEBC3CC1" modified="2021-02-10" version="1">MTLIRSAVCRACRRSQFQLRRNFATANGQQATSNTKVKLVEVGPRDGLQNEKKTIPLATKIDLIERLARTGVSTIEAGSFVSPKWVPQMANSSEILEHLLQNKVQAPVPMTYSFLAPNTKGLQNCADILKANPETFSTQLDPRADSNGEPKPAMEVAVFAAATESFSQKNLNCDIQTSLERFKAVIQDSKALGLRVRAYISVVLGCPFEGFDVDPHKVAEIATDLLESGADEISLGDTTGMGTAPRTSALLRCMSAAGIRTEDIAMHFHDTYGQALVNTAVSLEHGIRTFDSSVGGLGGCPYSPGATGNVSTENMVYFMETLGMDTGIDLDAMTDIGSWISTELGKSNGSTVGKAVLGARARAAAEAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z375</accession>
    <name>A0A7D5Z375_9HYPO</name>
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        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hchA</name>
        <name evidence="8" type="ORF">G6M90_00g067200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014683784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z375"/>
    <dbReference type="GeneID" id="26247944"/>
    <dbReference type="KEGG" id="mbrn:26247944"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:protein deglycase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017283">
        <property type="entry name" value="HchA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
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        <property type="entry name" value="PRK04155.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF20">
        <property type="entry name" value="PROTEIN_NUCLEIC ACID DEGLYCASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037798">
        <property type="entry name" value="Chaperone_HchA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="294" mass="32358" checksum="056BCD57C81B87A3" modified="2021-02-10" version="1">MSNTSDRAPVADQAEFNAWFPSKYSLTQYTAPKTDFDGADYPNAYKGGKWKILLIATQERYLKMAGGEFFSTGNHPVEMLLPMVHLDAAGFDIDIATLSGDPVKFEVWAYPKEDEAVKKIYAKYEDKIRSPLNLQDIWGKNGFTTETPYLGIFIPGGHGVLNDVPFSKLVGDIIRWAHDSQRYYLTLCHGPASMLAANVGKPDGSKFIYDGYEIVVFPDSLDTGANIDIGYIPGKMPWLVGEELKKLGVTPLNKGITGQVHRDRFLLTGDSPLASNALGKLAATTLLEDVAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z376</accession>
    <name>A0A7D5Z376_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g030550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539472.1">
        <property type="nucleotide sequence ID" value="XM_014683986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z376"/>
    <dbReference type="GeneID" id="26247746"/>
    <dbReference type="KEGG" id="mbrn:26247746"/>
    <dbReference type="OrthoDB" id="4938517at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="15230" checksum="21228D44712E8452" modified="2021-02-10" version="1">MSHANYHHSSPYYAHLIQTDNRSNPGDWGRWFVAAATREDMKTFFRGLQKYSKTSNAAITEVEPVHLAWWTFKSANSWAPLELVKQIYQLNTSSYGNIKELSESHGKVAITVLSDGGGRDWPILPNQDVSLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z464</accession>
    <name>A0A7D5Z464_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g034090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543336.1">
        <property type="nucleotide sequence ID" value="XM_014687850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z464"/>
    <dbReference type="GeneID" id="26244137"/>
    <dbReference type="KEGG" id="mbrn:26244137"/>
    <dbReference type="OrthoDB" id="4941011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028878356" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="37350" checksum="B65B043B33AFA25A" modified="2021-02-10" version="1">MKAVSVVVAAVAAGIALVQSHFQMAPCARSCIQKALPNVGCTGNDKDIAFCLCRPRTKSKLVDPVAQCANQSACSAADLLRAQSIIDWRCQNVHPASFSEATFDEPESASWRQATQTPQPVPSSSSTSTPSSTPSESSTAISTASGSSGLSTGLVLAITSAVVAALGSLAGAFWCYRRRHRRRASSGQVRNGPSEEEKDGHPTRSGHNELLGSTEMAHEMDIYVPQQPTPAGLSKQVYEIDSTPLRMVPGSSALEAGQIVSNAAPPGSPRGPTRADGMKSRTLSDMRTAAQENGDQDTPVLGELQKRRIILAEERRYLQRVHEIECEDKRLEQQISDLTQQQPSSPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4A1</accession>
    <name>A0A7D5Z4A1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g103980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987697.1">
        <property type="nucleotide sequence ID" value="XM_066131633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4A1"/>
    <dbReference type="GeneID" id="90968193"/>
    <dbReference type="KEGG" id="mbrn:90968193"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22004" checksum="7E20718CF62AFED6" modified="2021-02-10" version="1">MAAPAFHESLPYIDTPSESELARARALVTQEAQASPRGDTTRQAAPEPAFSETMQTELARVASSTALTPLDTSRYEAQDLPPPGETGTAPVLGRAYTSAAYLRGRLQNLELLERHGAPAWLLANYHLEAALGRAEAELTRAKGEVDGVNDARRRRQADVAAEMAGLEETWRTGVGRVLETELAVEELRASIREELRKKGGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4F3</accession>
    <name>A0A7D5Z4F3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps-25</name>
        <name evidence="6" type="ORF">G6M90_00g071310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987196.1">
        <property type="nucleotide sequence ID" value="XM_066130950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4F3"/>
    <dbReference type="GeneID" id="26241961"/>
    <dbReference type="KEGG" id="mbrn:26241961"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10470" checksum="2E36482BBCEB180E" modified="2021-02-10" version="1">MAPAAGAKKQKKKWSKGKVKDKAQHAVLLDKTTSEKLYKDVQSYRLVTVATLVDRMKVNGSLARKCLADLEEKGLIKPVVTHSKMKIYTRAVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4G2</accession>
    <name>A0A7D5Z4G2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase get3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">get3_0</name>
        <name evidence="4" type="ORF">G6M90_00g011810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549341.1">
        <property type="nucleotide sequence ID" value="XM_014693855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4G2"/>
    <dbReference type="GeneID" id="26238785"/>
    <dbReference type="KEGG" id="mbrn:26238785"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="3">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="14095" checksum="9BDFAD9EB462A747" modified="2021-02-10" version="1">MSSAIISADDALEPTLQSLLDQRSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFSQKFGKEARLVNGFDNLSAMEIDPNGSMQDLLAGQGEEDMNAMGGGIGGMMQDLAFAASYTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5F6</accession>
    <name>A0A7D5Z5F6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g110670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543792.1">
        <property type="nucleotide sequence ID" value="XM_014688306.1"/>
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        <property type="component" value="Chromosome 7"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028946906" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="271"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
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        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="28907" checksum="D6A2DE7C044747E5" modified="2021-02-10" version="1">MRSFSLAALLLASTAAALPRNECFRVHSKALAEYTDCGNQAAVSRCLASLSSFEPSDLAPCYTNAGCSASQAALEARYITTRCQEYSTGNELRKRFRAALEPVRATQAVVAAAHLAARATTTPAPVRKGADCFSASEFDTSSCDVATENGKAVTRTCTPSKGTSSDCLSGWICTVDSTHQDICMKKQPIDTGGIIVAIVFAAFFAIGLAYLTFACCRERKHHKRVAAKAEAVALARAATKKQRSQEARAPLMQQTQEASSPNPFQDQPSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6W8</accession>
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        <submittedName>
            <fullName evidence="3">DNA repair protein rad9</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g042030</name>
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        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the rad9 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
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        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cell_cycle_RAD9"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="309"/>
            <end position="476"/>
        </location>
    </feature>
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        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
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        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="490" mass="54146" checksum="AD771B661B6396BB" modified="2021-02-10" version="1">MAILSFTLSEEGVSAFRDALICLNKFSDDVSLEARKDSFVLTTLNSSKSAYASFKFATNRFFSKYQCQPMGQFRDRFYCTLYIRVGDSLALEIISTTTLSALIPLSLISLFRSRSSSESQRDAEKQTLIDRCDITVEDGEGIKSRFIARIVFRNGLTSTHRLPFEVAVPVHAKFNRQDAPHHWTISSRTLRQLMDHFGPGIEYLDINTDGDHVNFTCFSEKTVNEDAVLKKPLQTSIAVETDEFDDIDVEDKLHVVISVKDFRAIVQHAGITGNAISARYSLPAKPILLSYVGDALACEFLIMTVGERGSNPAQKTKKGRKATAAAASGPRLEAASRRTSVAPNETTTNIQPYQLSQSAPSIAKPTVPNPTPHPHISAARASASRIGAFDLRPSQKPPPPTIRSESLFVDDDGWEPVRDEEEDVEQDARLEWDHSADPNPSALQLSRIEERHAASVGRQEAADAQTAPESTYLEPTQKLSDVKSLALFPD</sequence>
</entry>
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    <accession>A0A7D5Z7J6</accession>
    <name>A0A7D5Z7J6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g070900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7J6"/>
    <dbReference type="GeneID" id="26241998"/>
    <dbReference type="KEGG" id="mbrn:26241998"/>
    <dbReference type="OrthoDB" id="4940863at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="74" mass="7891" checksum="D1AFDF6A83D87069" modified="2021-02-10" version="1">MSEKTTPQGPFHPADPSSAASGEAAAARATSAADAWKPSFDRRQSWSKEDQKHALQMRAVEGVKTGLGFTEKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7W6</accession>
    <name>A0A7D5Z7W6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QLI68889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986689.1">
        <property type="nucleotide sequence ID" value="XM_066130734.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90967844"/>
    <dbReference type="KEGG" id="mbrn:90967844"/>
    <dbReference type="OrthoDB" id="4941440at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013869">
        <property type="entry name" value="DUF1757"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="178" mass="18553" checksum="F8F6C5BFE7E371FF" modified="2021-02-10" version="1">MSRYFPHTSYAEDQPVPHVVLATHVLTRALAAGSLAGLGVAAARQAVPAWRRPRPGGGPALVSHRILRASSAGALWGLGVGAAALAGRMYGRELVEWQDRSWRLLENRGQLEMDDWTYLGMGAGVAAAWAAGSLKGLGGRGVMGAVGAGGVVGGLAWAGWRFGVNGGRFKEKPKEGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8D7</accession>
    <name>A0A7D5Z8D7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Something about silencing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SAS10</name>
        <name evidence="7" type="ORF">G6M90_00g087150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542403.1">
        <property type="nucleotide sequence ID" value="XM_014686917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8D7"/>
    <dbReference type="GeneID" id="26244917"/>
    <dbReference type="KEGG" id="mbrn:26244917"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="545"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="620" mass="69147" checksum="8AA2B1D3903EC3A9" modified="2021-02-10" version="1">MAKKRKAGSRNAGPKGPKELDPSEARLGPITTYQDVADSEDEYFLNKDTIMLDDEPNSKRRRQEDEDMEFSDEEILGYEDSDSDEQDDKPDAKPQTKSKKSTTKQDDAQGDLEDGGEEDDEGDSGWWGSSKQEYYDADNIETEADALEEEAEAKRLQQKKLSKMREEDFVFDGDEWLTGEPELEEGEGKVVEVLKDIEVTPEMSIEERSRLLSTRYPEFEHLASELEELHPVYLGLKEDAANQPDTSIAAIKYCVLGCYVATLASYFAILTSPARDAGKLQKPLSATDLRDHEVMEALLSCREAWDRVKNLTAASNPDETSLSLSADLDGQYALNDDPTALDTTKKKKSVKKDKVSVAKEAKKLEKARAIENTVSDLYSLPIGSGKSKRKSKSSSASKEDNNSDFGEEDTLDARAAADKAARKKSLKFYTSQITQKANKRAGAGRDAGGDMDIPHRERLRDRQARLLAEAEKRGKRDSKHGADLGDDSDDDDNTAANALRNDEDEYYDMVANKSKNKREEKAARYAAYAAASKADRVVENEEVGEDGKRKITYAIEKNKGLAPKRNKDVRNPRVKRRKQYEAKQKKLKSMKPVWKGGEPKGGYQGETSGINVGVVKSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8I8</accession>
    <name>A0A7D5Z8I8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g110310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543828.1">
        <property type="nucleotide sequence ID" value="XM_014688342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8I8"/>
    <dbReference type="GeneID" id="26243215"/>
    <dbReference type="KEGG" id="mbrn:26243215"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="36853" checksum="30D7738EED17BC20" modified="2021-02-10" version="1">MSPADQGTMDHWVSSTKSTTVRRASLNPTSRPPVSMSGQAPRYDQSSRQNQDLATVAKETRIVLPKILQRLPNIQAAKSEALYLSTLSPLKAAECPRRTPSRKVAIKIVNDDSFNAAIKLTASKGVASAGRVVVLNMASHANPGGGWLKGARAQEEALCYRSSLSLSLHRRYYPFKQLMGIYTPDVVVIRSDMPSGHKLLTPDIPVQDLPVVSVLSIAALRCPETKRFRGNTPSGKVFERLAYANPADREMTKAKMRLCLRMAARRGHGLLVLGALGCGAFKNPKEEVAQCWLDVLRETEFQGGWWEEVWFAIFDSRQEGNFEVFEDVLGGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8K2</accession>
    <name>A0A7D5Z8K2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ERF2</name>
        <name evidence="14" type="ORF">G6M90_00g061340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542734.1">
        <property type="nucleotide sequence ID" value="XM_014687248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8K2"/>
    <dbReference type="GeneID" id="26244683"/>
    <dbReference type="KEGG" id="mbrn:26244683"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="450"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="632"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI69349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="662" mass="72535" checksum="B60CEDAC7190B5E1" modified="2021-02-10" version="1">MLSQDPADGAVSPGESSGIPPPSGGSSNHRPSSVVSSRMTDIASDDGGEPRAKNADPSRPETARTGTSSKATWAGPATRKGLAPGLQPKRGSVASTIASARAPSLTTRSHVPSLTSGAFFRPMSSQKLQAQRGAGSRPVPMNQQLHPPPANLDDNETDMGGSLIDGASGGENTQSIAQLQHRISAGQSVRPPPSRGTEMTDQETFDRFIANASPTTGHYPTASMSDSVRPLQGPSDQNRELSVHVDKSYRDLANLPSPVRSTRTFRSSFLLPGKMEQAQSSRHRDTTGAEKLSSTASSPRFPRTESHSGPRPLTTDSQRKSRGRVHQYFDGNTVFCFGGRWQNTKHTPINIATGAFVVIPCALFYGFEAPWLWHNISPAIPITFAYLTYICLSSFIHASVSDPGILPRNLHQFPPVADQDDPLRLGPPTNDWTLVKSADISAAAMEVPIKHCRTCNIWRPPRAHHCRLCDNCVETHDHHCVWLNNCVGKRNYRYFFTFVTSATILAAYLIGTSLTQILIHMNRESISFGDSIDHFRVAFALAIMGVLSIVYPGGLMGYHLFLMARGETTREYINSHKFAKKERYRAYSQGNWLKNMIAVLCRPRSPGYYRFKGKYRPGDQRLGQHYSLRTRKNSQGLELDEVPPGSRGFQGPAALRGESRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z924</accession>
    <name>A0A7D5Z924_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KCR2</name>
        <name evidence="9" type="ORF">G6M90_00g092070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541851.1">
        <property type="nucleotide sequence ID" value="XM_014686365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z924"/>
    <dbReference type="GeneID" id="26245319"/>
    <dbReference type="KEGG" id="mbrn:26245319"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="35888" checksum="1149F0CCE4F33D91" modified="2021-02-10" version="1">MPQSPSPIVALGWLTASYILIKLIHLVGIYILPSRLHRFAHVAPNGDSPWALVTGASDGIGAAFAQELATHGFNVVLHGRNPGKLNSVKDGLQKKHPSRSFRILVADASKVACTNCIPSEQHGQNSEALDFKAIGAELEGLHLTVLINNAGGMSTSPIYRLLMDSSEERITRNVSLNASFPLHMMRQFLPTLCRNGPSLIINISSLADTGFPLLSSYGSSKQFLMTLTRSVSLEMPLGHGPGSDQVELLGVRVGRVTGVAAYKEEPSLFTPSAQDMARAALSRAGYGHGCVIGYWSHALQTVGFTVLPKWLEGRVLQGVMRNERAVELSKKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z935</accession>
    <name>A0A7D5Z935_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g088390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542273.1">
        <property type="nucleotide sequence ID" value="XM_014686787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z935"/>
    <dbReference type="GeneID" id="26244787"/>
    <dbReference type="KEGG" id="mbrn:26244787"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="434" mass="47393" checksum="79908C470ABA1922" modified="2021-02-10" version="1">MSGARKSNADIEPFPPIEQGSPIELAQSSSADGSKNIGKNRPAASSSLSGRLRRVSQSFEQSELPEGFFAATGGIASSILSRQAGPRPVSSSIGSAKAQPAVRGDNALQPTPVHPVSEEGRAESKNDGSSAIQAEAKCKGEPPSAAPFPNGYHFPPKHSFGESTRLGLLAFWNYFLTPVGFAVTIYGLNVVAWGGMLFLLLCNASPAMCYPSCNDINSPRRKWIEVDSQILNALFCVTGFGLAPWRFRDLYFLLQYRLAKKTEALRRLAGIHRGWFRLRGSNELPPAAGPGTITRDEFQSVSRSAIPFPETKIPEAPLTGVRARPTLVWKLDLVIWLMVANTFLQCVLSGFMWGMNRYNRPSWATGLFVALGCGVAGIGGYIMFLEGKTVKSIEGVPVSQADTERLERDREQGIWHFNNIKDKNLDFRRKGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9Y0</accession>
    <name>A0A7D5Z9Y0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g084440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543659.1">
        <property type="nucleotide sequence ID" value="XM_014688173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9Y0"/>
    <dbReference type="GeneID" id="26243836"/>
    <dbReference type="KEGG" id="mbrn:26243836"/>
    <dbReference type="OrthoDB" id="5304511at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="52807" checksum="22BDB74E47A33FB7" modified="2021-02-10" version="1">MKRILSRARNFLKNPRLPKVRAIKSTAANNRSPQNESTDANERAQPDRLQSQSPAAISTLESLPSEVHRLLLSMLGIDETRALVSSSPIIHARYLVNRRYLLCRSLDNTLGCVSVDALAVFRSSSADFAKSRTRENVAGFLKLYQDQGGATEQPLLPRDVGEDEAVGMVMFHNAIVQPLARYYLTWSLGNLAREQRALQSHEPPSGTEETRLMRAMYRFQLSCNLFGRGKHAPTLSPPLGFESADILRLFLCLFEPWEVEEIACINTFATEKYDRIFSDIRWDVHEENPKFDGQRPPTPDGAFDFDNSWTRLSLLRGTISRGLELLYSVIFKVQDHEHLVSMMQEEIPFPSGNVLDDAFSEGAQFHRRRNHPSKRDLKQTRREPLPFTGEANAGDLLPPLGWTIIWHGTYSNLYGYYVQDSIRRWGYVIWDAVRLERTNATEVLAQQWRDDWGDSDPRNNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAP0</accession>
    <name>A0A7D5ZAP0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RRD2</name>
        <name evidence="10" type="ORF">G6M90_00g098070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546536.1">
        <property type="nucleotide sequence ID" value="XM_014691050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAP0"/>
    <dbReference type="GeneID" id="26240959"/>
    <dbReference type="KEGG" id="mbrn:26240959"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="430" mass="47595" checksum="70A1B25242439968" modified="2021-02-10" version="1">MASPQPSSSPAPLRNAAPAIPNLKDRIPKLEPRRRRQEPDNPTPVPETPALPSPPNTSDWTFIVPKRRILSKKDHETFLASPTQSLITGWIFGLAESVTDTPCSAVKSDDLGDTVKAILNILGEAGELVIKCPPNEQGGSRFGNKAFRGFLDLVTENCPKWHESLGIDREAAIAEVSTYLDQSFGNRNRIDYGSGHELNFMIWLLCLYQLGLLQKHDFKAVTLTVFPKYLSLMRTVQMTYYLEPAGSHGVWGLDDYQFLPFLFGASQLLHHPYITPRSVHQQLTIEEFGKDYLYLGQVAFVNDTKTVKGLRWHSPMLDDISSAKSWSKIDGGMRRMFVAEVLGKLPVMQHFLFGSLVPAGEGMSEDDAVDSDGDEHAGHVTSDLADHSDHAHDGTGWGDCCGIKVPSSIAAAQEMKKRAKGDALRRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAU2</accession>
    <name>A0A7D5ZAU2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PMS1 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PMS1</name>
        <name evidence="5" type="ORF">G6M90_00g098560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546488.1">
        <property type="nucleotide sequence ID" value="XM_014691002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAU2"/>
    <dbReference type="GeneID" id="26240911"/>
    <dbReference type="KEGG" id="mbrn:26240911"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="217"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="652" mass="72058" checksum="B03493D6EB9F3C43" modified="2021-02-10" version="1">MSIRPLPQSTVRLLDSSMNITTPYDLVKELLDNALDSQATAVEIAASSNTIDRISVRDNGSGIDISDFGALGRRAHTSKLREYSELVEVGGTTLGFRGEALASANSIANVSIITKSPGDPVAWRIELIPGTGGVKDRRPVSSTVGTTVAVTRLFENLPPRKQYALKQAKNCISQIQQLLRQYVFARPNVKMSLKIIGDTKPLWAYSPKPPDLKREAILQILGANGMVNCIEVYEEIHFNRESISQMETREPARWVFSGYIQKPYIISKDFKVRGAHLSVDNRPMSAGWHVTKKMTSILKSHISQTTAPKSAERQCGVFLQINIRCPPRSYDPNITMRKDELLIFDEKGLLDGFELVCKRAYEKHNQALAATHPPATASTQPNNARECGRQLATELEDECVSCASIDEVSGQHDNLDNTQAPQNTSRATRPKIQTTMKTTFTVNMGRKEDSDSDEENMDMGIEVEIPAGPPSVRDSHTNNQEQHPRQTKTIRHYFQSLPKDGFKISHDDTATAGTVVASPVGPQLDESSPSNRTPLQPLSDIALNRIREEAESTPEPPGSDSIVPRHIINASRRDIVPSLRRVANSTRHLGAQGPERTTPSLYLAGTNSEETQDDEILDIDMSKRTGRLDLVLSLAIHSSLEQTLLDKVITSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAU8</accession>
    <name>A0A7D5ZAU8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g112120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987965.1">
        <property type="nucleotide sequence ID" value="XM_066131848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAU8"/>
    <dbReference type="GeneID" id="26246878"/>
    <dbReference type="KEGG" id="mbrn:26246878"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="48370" checksum="A514AB14F06711B6" modified="2021-02-10" version="1">MYQNVVIYYNDSVDSDNLAAAMALMRAMETRPNTRLLWIVEPRQVSFGLSPTKEQQDKCEEVVKKHFPTRGNPWKILFGGLLSESDLNGIEELSTHDRELLQLAVKPSYGPKQDAILHRRLTAWDQVTCMAGWSKASVEILMDLESLDEIENPVNLNFHYKEELAARSVDELMSYQDIMNEPFAQRVESLRGWYRRCIERAETRPENHGSSVRPLDFNSLRDAIQTAGSVRFFGGASLTILQRFIQRGVASHVRCHLQVGSYDPSANLFPNQFNISLNPKAARFVFNHFAEFSEFAVVPSHAAQSTKYSLAGLKHEGGRCLERRVLGFNCREDPLKIAEKQVTIEKDYPNQACPMPDLTAFLCALIPKFNGATLGYAQVDDDNGALIFRREGSGIPMYDIMDNRTLKETEVVATLSSLAAGKDMPELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAV4</accession>
    <name>A0A7D5ZAV4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hybrid PKS-NRPS synthetase prlS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prlS</name>
        <name evidence="2" type="ORF">G6M90_00g093530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987653.1">
        <property type="nucleotide sequence ID" value="XM_066131450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAV4"/>
    <dbReference type="GeneID" id="90968136"/>
    <dbReference type="KEGG" id="mbrn:90968136"/>
    <dbReference type="OrthoDB" id="5245411at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase (KR)" evidence="1">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="202" mass="22577" checksum="9B2E58FCFE9C3EF3" modified="2021-02-10" version="1">MKALLPESIAVFADFGVTGESSRVSQQIRRHLNATGRRETIQTIFGGLARKLTEKTKEKFQIMLEDSVASAVCGLVPTIQVTNAANVIGLANIDIIKGHLAYQYIVDWTIGDRVPALVEPIDTHPLFSSDETYWLVGPAGSLGLSLCEWMMRKGARHIAISSRNPKVDDIIYMQELQTTYEEIRSNMPPIAGWYFMIFSCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB38</accession>
    <name>A0A7D5ZB38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MPH1</name>
        <name evidence="18" type="ORF">G6M90_00g101210</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546224.1">
        <property type="nucleotide sequence ID" value="XM_014690738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZB38"/>
    <dbReference type="GeneID" id="26240647"/>
    <dbReference type="KEGG" id="mbrn:26240647"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18801">
        <property type="entry name" value="SF2_C_FANCM_Hef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001992">
        <property type="entry name" value="ATP-dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.20">
        <property type="entry name" value="hef helicase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="169"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="513"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="697"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="862"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="988"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1048"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="926"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="993"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1077" mass="121153" checksum="ED53E21EDB408B98" modified="2021-02-10" version="1">MDDDEFGEDFVDEDFLEALDQVSSSNRARPISQPSSNEAQFENKTWTKSNPLAAAAQELEDLPLDAFSSPEPETSTSVAAAPTSRKASNGPRVQNGLTRTASGNFRQTTLWGTEVREDAPFRTQAPIQRVFRADVPHEEPSHHELDRKEMETWVYPTNLGAIRDYQFSIVKNSLFNNTLVALPTGLGKTFIAATVMLNFYRWTKSAKIVFVAPTKPLAAQQIDACYNIVGIPRSHTTLLTGDIQPALRADEWEKRRVFFMTPQTLLNDLSHGYAEPKSIALLVIDEAHRAVGEYAYAKVTKLIRRFSKSFRVLALTATPGSKIETVQEVIDNLGISHCEIRTEESIDIRQYVHERNIEKMVLDPSDEMNLVSELFTEALKPLVDKLGSQNIYYGRNPMAMSTYGLMQVQKEWFATRGRHANQGVQFMMRAIFSVLTSLAHSIKLLNFHGIKPFYDNMKDFRSEQEGKGEKGSKYKRQLIEHSSFQKMMDHISRWLRTDGFVGHPKLAALVDCVLNHFMDQGEGSTTRVIVFSEYRDSAEDIVCQLNKHQPLLKASVFVGQADGKRGEGMKQAQQIQTIEKFRKGEFNVLVATSIGEEGLDIGQVDLIVCYDSSASPIRMLQRMGRTGRKRAGNIVLLLMRGKEEDQFAKSKDSYESMQKLICEGSRFNFRFDLSTRIVPREIRPEVEKKFVEIPVENTQDPSLPEPKKRRPAAGKKKPPKKFHMPDGVETGFQKLSYYMKSGPKPEQSKPKQNPELNDLESIPDLSSVALTEEELKELDRSYRDLPFNHSVVEETDMPSMTAYPLFQRQLRPVANLKHGTCTRRFVKLLAKMGTEPESLVRQCRSTDTSHFKDITVRAFIASDGEPDVDDTSDSGTKKRSTRQRSMEADNEESQPPRGKRKKISTTSIAGLSELEDDSETPGMNSRARKRTKKPKSKRKGRKTKQRTGINSDELGDDCERDSDLIENGGSDDGADLLDFVVADNQGTSSMVGSQVTSPTTASAQSTPKAESKQPFYVPTRFSATQESDDMPDVDTLVKRKTFQKVISMDASDSDLEDLAAKRPARGRRQVFDSDSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCI9</accession>
    <name>A0A7D5ZCI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g095780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546752.1">
        <property type="nucleotide sequence ID" value="XM_014691266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCI9"/>
    <dbReference type="GeneID" id="26241175"/>
    <dbReference type="KEGG" id="mbrn:26241175"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="26218" checksum="365F54470A6F854F" modified="2021-02-10" version="1">MFARPRPKKSILPPPSKKRKTTSTIEEISFDDDARTEYLTGFHKRKQHRIKHAQEEAAKRARQEKLETRKQIREDRRREVAEHVEAVNRILRESGAVSSQIDEGEESGEDVDEWDGFPDKPDLDLIDHEEEYIDEDRYTTVKVESVSVSRDGLSRPDEIDDEAEEEARRKREEAEKKEAEAKDKKKPSWQKKKKKKFRYESKIERQLTDRKQKAKSKSRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPE2</accession>
    <name>A0A7D5UPE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g017060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548824.1">
        <property type="nucleotide sequence ID" value="XM_014693338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPE2"/>
    <dbReference type="GeneID" id="26238268"/>
    <dbReference type="KEGG" id="mbrn:26238268"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="27324" checksum="4CD99A35E32893F7" modified="2021-02-10" version="1">MSPPTNAELNKKREENCLQITTDMKYYRVGQTWIKRSLRPSEWQKEDGYMPIPLFSLERVLNEGACLRHLADKTNIPIPKLHACFEDDGAAYLITEYVEGVAMSWLDEEQREVVAKELCIHMKALSNLTHHIWGGPSGLVMPPYRIMQYSDGRPWKMKPRRENNLVFCHNDLSTNNVIVAPRTLKINAIINWEYAGYYPQRFESAFFQRLGPSIALKGEVDDTEWLHKILSEERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPI5</accession>
    <name>A0A7D5UPI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-coenzyme A thioesterase 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Acot13_0</name>
        <name evidence="4" type="ORF">G6M90_00g022440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548310.1">
        <property type="nucleotide sequence ID" value="XM_014692824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPI5"/>
    <dbReference type="GeneID" id="26237754"/>
    <dbReference type="KEGG" id="mbrn:26237754"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="167" mass="18666" checksum="EB92F529B6E02A64" modified="2021-02-10" version="1">MVDKKYEDLYEDPLERAKAWLTKDDDDHWKAGEWMSKLLPHLVVLAANPDAPAPSVTFTFTCLEDHCNRLGNLHGGAAATLFDLCTTIPLVLISKPGFWQFLGVTRNLNVTYFRPVPKGEEVIIECEALQVGKRLATLKGVMKRKRDGAIVSIAEHLKANIDPEPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ56</accession>
    <name>A0A7D5UQ56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985706.1">
        <property type="nucleotide sequence ID" value="XM_066129607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ56"/>
    <dbReference type="GeneID" id="90967428"/>
    <dbReference type="KEGG" id="mbrn:90967428"/>
    <dbReference type="OrthoDB" id="5420777at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="511" mass="53491" checksum="0447AFCC2F757C7F" modified="2021-02-10" version="1">MECPIGFDDCYVVGEPKSADEHVSTSTITRKCTLLCDEEEPMTIYSIVHTKTVTFYGNRTDYTPPYSTIKTPVYCLEFEESPASSTAEGDFPEVTQVAAGTTTDFFRSLTPFIRPKVTFITTDKNPSVVFPSDPPPNYSATWSDPYPNPIIHKSVPPEGDQGDQGDQGDQGDQGSLGRQGGLGRTPEGNNQPRPTFNVTAKGNEVIINSEIYSSLKPDQTTTVSVDGGKFTIYPTAIVGLGGTVAKPPPSPTKFGVPSPTNGTVGGLDVSLSGSQVAIGGVTMTMPPHGTTTNIQGQSVTISANQIIVGTRSFKFNPVQAQPESEVVVAGGEMLTVAGKSVVVVHSKTITYGPDTPITTEVVEGDTVTIGPSGVRVHGLVLGGFQANETDTKYEIIGGATITKIAPSVAIINGDTFTVGPGSHLTTTVIAGQEFTLGPMGVIVSTITLSYPFGSTVVTTIAPTGTWLNTLPIETSRSPKDDDDDSMGPSIRPSLSCAGVALCIAIGVLVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQH8</accession>
    <name>A0A7D5UQH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g015210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549004.1">
        <property type="nucleotide sequence ID" value="XM_014693518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQH8"/>
    <dbReference type="GeneID" id="26238448"/>
    <dbReference type="KEGG" id="mbrn:26238448"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="190"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="563" mass="61232" checksum="F30AFA9703D3644F" modified="2021-02-10" version="1">MGQDSTAITQSSGYNDGWATISPYSPSPYDGSPMTEYSGFGTFVPPGVHSDSMPRMPQQGGHQHQHQMMHHSATPMGHHQLPMLNTTWPSQLTNPTPSSGSFSAPATSIPPVPRIPRAIDTPKLPSQADKGRKTLTTEQKRAMCQYHEENPGTRQADIGLRFGVERSTVSKVLRHKDQYLRRDQEPDPAALKRSGKAKNPDFDRTLSNYVRRQQQRGFDIKDEEIMEQARLFAHASGNQDAILGSLTSGWLQKFKQKHGIGTSRLSRRASETNIADSTRMPEHNLVRNGATSNDISPASPTQPLSPLSGSRSDEEVKREQNIDYDFAYRQQHSQPTTSLATDIRDNPGSSFSGGTLSPTGTFNFSPDPNAGSFQPLGMRAEMPPEFHREKRSNTFPSIDVSYGNQATPATEPMTPQLPAPTTAPSSALDSPTNDGQIAHFSINTGLTSPPALHRTSSSSSIAARSSSISLTNTGASMTPVDSSPVSPSQEDARRAANTLLSYLHNMSSTGQLFQGDYQAMLQLTKKLEIHQHQSNRPSAGGLSRIPEGDNEMNATGPAMMQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR24</accession>
    <name>A0A7D5UR24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tripeptidyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g019640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548578.1">
        <property type="nucleotide sequence ID" value="XM_014693092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR24"/>
    <dbReference type="GeneID" id="26238022"/>
    <dbReference type="KEGG" id="mbrn:26238022"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="163"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="6">
        <location>
            <begin position="516"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="71089" checksum="F3EB175990EF4361" modified="2021-02-10" version="1">MKQADQQPGGNAPGFLTRLAILAIGIAPTLVLSVAASPAALHHSRQANPADTTGDFPKPDDPFHFIPCISNKTIEGIPLLNDTNPQETWRKMFDPNPDNWKWGPAPGNATTPGSSNSTQGRGLHLCGYLDVPMDYLNKSDSRIHRLAVAKYQASGLKGKGARTIVMNPGGPGGSGVFFGLSGGYYSRILSNGLLDFLGFDPRGVGLSQPTIRCYPAALHDRWNLAVGKSLRESPSPRQQLELVNAVNDARFRACFEKLGDVPRFVSTASVARDVDAIRVALGEPELTGYMASYGTTLGQIYANMFPDKAGRLILDSVDYSREHRVTGGYAGTKVHSTTDAWNEGFLGECVAAGPSNCALAKPTNGSGVTLDSLKERMAKLLDGLAERPIPAYDEDKGPVIITYSLIMWWIRRALYNPRYWLTLAEALADLESGNTTIAALVAHGQFIHQPREPERPLALASELLTMVVCGDASADGPPASGLDFWESLWRNLTEKSFLSGGSHFVTVFPCQNYNKYWPQGAALYQGDLNNKLKHPVLLIAETHDPVTPLRNARELHKEMGMENARLVVHHGYGHAFLSDPSDCTIAIIREYLLNGTIPDKRETDCYANGKPYRNSTRTNHKRSLPMVGDGLERPVHNVHMPDWVNMQQGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URD0</accession>
    <name>A0A7D5URD0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactose regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LAC9</name>
        <name evidence="7" type="ORF">G6M90_00g015530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548975.1">
        <property type="nucleotide sequence ID" value="XM_014693489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URD0"/>
    <dbReference type="GeneID" id="26238419"/>
    <dbReference type="KEGG" id="mbrn:26238419"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="699" mass="78586" checksum="03DCA580D2D99E3F" modified="2021-02-10" version="1">MSSSQASATSPPPPSGRKVNRSCTECTRRKIKCDGRHPCSSCVYYRSADSCEFRQRSRRNAVSRSTFDKTSEQLKLQSKVLETLFPGSNLKDLLEKSQSELLELLSVNHVSPRSKVHQLPPHMPITPGPPPVLPQRREEDGQFASGSPAQGSASVSENGEAAEERQWDESLDQPATVASDDINALGLAADNHPARSYLGVTSMSAVFRTIFQLCPAAKEHTNKCARSLAAVPSPAHPAVPVTGRDPALSVLREQRFIDFYFEHVHPLTPLLDEQDFRSQYASGTRRDGSWMGLLNMVFALGSIASGSEGLHEQYYREARSFTGLDSLGSGNLESLQALCLLGGYYLHYRNSPNMAYGILGTAQRVAIALGLHREPRRAMETPDPGEMESCRRRVETRRRTWWSFFCLDTWACMTQGRPTCGRWESSTMDTYFPSCLYPDDQEATLLRANIEFCLIFERAQHRYAQFSRLSNQEILALDAELQTWYKSLPQETKQVDNAPQRFRFARELLKTRYYNARIILARSLILYMAHDLKRKPAELLPEQAHILDHCCSIAAEAIDSTARYWSPNRIHVWHSSWYLFQACTVPLLSIAINRNMEQRQQKQVSSPSSDRVVSWQTSLAKALDTFAEMRPWMRTSDRSPDIVSALYEALTAAGEVDGQTPSATDGSLDLFGWCDDQLTELDWGVFLGDEGLARGMYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URT8</accession>
    <name>A0A7D5URT8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g001850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542893.1">
        <property type="nucleotide sequence ID" value="XM_014687407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URT8"/>
    <dbReference type="GeneID" id="26244266"/>
    <dbReference type="KEGG" id="mbrn:26244266"/>
    <dbReference type="OrthoDB" id="4897974at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9101" checksum="FE6F3E73CD02E50A" modified="2021-02-10" version="1">MPTSQVPPGKTAVTARSEEECYDLFVKEISSIPDREVPGTQNGESGTEQNQAGPIPQLSRGTTPGTSTNVMIAKTIRAAMAGIRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US30</accession>
    <name>A0A7D5US30_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g002500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542831.1">
        <property type="nucleotide sequence ID" value="XM_014687345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US30"/>
    <dbReference type="GeneID" id="26244204"/>
    <dbReference type="KEGG" id="mbrn:26244204"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="125" mass="13452" checksum="BC6E9F3C72F969C2" modified="2021-02-10" version="1">MAAVWHDKTETVKFLLGQEANVNATSTKSCPYYTALQAAVKRNSPTMVGILLEHGADVNLARRLSSSALCAAIREGSIDITKLLVEAKADVGSSRGMPERLAIQKNRRDILEILVDHGVVPGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USC2</accession>
    <name>A0A7D5USC2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RPA190</name>
        <name evidence="15" type="ORF">G6M90_00g004800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542127.1">
        <property type="nucleotide sequence ID" value="XM_014686641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245158"/>
    <dbReference type="KEGG" id="mbrn:26245158"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="345"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1403"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1427"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1659" mass="183860" checksum="A5981871BE312A2B" modified="2021-02-10" version="1">MNIAQPISSEVDAVDFTFLSPEEIQAISVKRIENDSTFDSLLNPVHGGLYDPALGSWGDEPCATCSLISSSCPGHPGHIQLPAPVYHPVFMDQAYHLLRATCVYCRGFRLPPKDLHKYMCKLRLLQHGLIREAHVIDALGETDSSEMDEALGLGESEADEENSSFDNVTRKREQYVQVCLRSSALRRGDTRKGKHEGMAQARREVIKQFLAEINKKRQCASCDGISPPYRKDRYVKIFEKALSPKEQVKMIKKNLSRKDAMTRHYDAKLDPKADVEMSEPDAIVESLSDQDEEEPDVDGASTQRYISPMEVRARLSELFKKEQDLVFLLYNSKPRTRRSPDVTPDMFFITTILVPPNRYRPEARMGDSQVTEAEQNSLYKSILRGCSKIARVYSVLKSEERVDITQLHQAWTELQEGVNALIDKSKNPVQGAAAKRNEDGIKQKLEKKEGLFRKNMMGKRVNYAARSVISPDPNIETNEIGVPPVFAQKLTFPEPVTSHNFRDMQQAVINGANTWPGAVAIENENGQVQMLKNKSVDERISLANQLLAPTNPAAVRLKNKKVYRHITNGDVVLMNRQPTLHKPSIMGHRVRVLPGEKTIRMHYANCNTYNADFDGDEMNMHFPQNEVARAEALHIADTDHQYLSGTQGKPLRGLIQDHISISIALCTRDTFFSRGDYHSLVYSAIRPESGHIFGERIQLVPPAIIKPVPRWTGKQVISTILKNTQPINYGALNLRGESQIKAEQWGTNSEEGTVLIRDGEFVTGILDKSQIGQSSGGLIHAIHEIHGPAIAGKLLSAFGRLLTRYLNMRAFSCGVDDLKLTAKGEEARRQELQAINRVGLEVASNYVSLKDVSDSQNPVLLERLEEVLRDDTKLEGLDLLMNQSTKDITDKVQKVCIPNGLEKPFPRNQMQAMTTSGAKGSRVNASLISCNLGQQVLESRRVPIMVSGKSLPCFKPFETNITANGYIGSRFLTGIRPQEYYFHHMAGREGLIDTAVKTSRSGYLQRCVIKGLEGLMVGYDTTVRDADGSIIQFLYGEDGLDVTKQTYLKDFGFILRNLTSEVAQLRYDPQVVKRLGADRELFTKYMKSAVKHSKPGDPKGRDPLISAFNPATNAFVLSEAFYNAMSSYLKANADGLIREKRDKSAPDSSNALNKKNAEVLFAMKYLQSLVEPGEAVGIVAGQSVGEPSTQMTLNTFHLAGHAAKNVTAGIPRLREILMTASKDISTPAMSLYPRDSLSKQEAEAFTNSISALPLSHILDSVIVEEKVGRGKIYPSAKIYHIKLKFFPPQEYFEMHHASISDVLDAVEWKLLHHLIKLSKAELKKRALDATAATPDIGAKVGVVETAAASGETVGDDDDGDDAGDDDFTSAKERANRLEAVSYGPNDDADDEIQQAMDEDAAADELEVESLDGNPQKETTSEDEDESAERKVADSAKPRAQRVMCAFPEVTGFEYDEAVGDGCNVTIEFDAKVPKFLMLNIVQRAIKKTMVREIRGIGACRLDEEGGGGKERVIHVTGANIGAIQKYSDQIDPDRIQTNDIVAVLSMYGVEACRSNIVRELAGVFGSHGIKVDNRHLNLIADYMTRNGDFTAFSRLGLQGNVSPFTKMSFETTLAFLKDAVLDGDWDELATPSGRLVMGRLGKLGTGSFDVLTNLPTVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USG7</accession>
    <name>A0A7D5USG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase eqxH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">eqxH</name>
        <name evidence="10" type="ORF">G6M90_00g003310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541989.1">
        <property type="nucleotide sequence ID" value="XM_014686503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USG7"/>
    <dbReference type="GeneID" id="26245020"/>
    <dbReference type="KEGG" id="mbrn:26245020"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="528" mass="59891" checksum="658DD729F178D6A8" modified="2021-02-10" version="1">MAFESLLGSIDPVPLSEPPSSHLHCARLWAFVLLALVALYLRMSRHAQQNADFTLANPPKWYELKIVKQIRFLFNGISELDKAREKANGNPFRLLTNSREIIVLPPSYAEILNAEDRLSFAKYFADEFDGDGKTPGLEPYTLIADPCKTVPKLVTKRLTRSLNTIPIKMSSEASFAIEYNFGGGVNWQEVAIHQHLLDVVARMISRLFWDGDEVCRDERWLQIMKEWSVNSVIAAFMINMAPSFARPLIRRFSPTVRRARDDYQAARQFIEPLINVRRQAREKARESGERALAFDDIVDWIDSENEELTCDPVALQMVLNVAAVHTTAALVTNTISFLASDPSTLEPLRQELVAELRSNGCQAAALNNLKLLDSAIKESLRLKPPGVFGMHRAALQDMQLPNGMRIHKGDRVFVDIPHMRDPNIYESPNTYDMYRFYRMRGQPDQALKAPLVHTSPEHLAFGHGAQACPGRFFAAILSKVVLSHLLLKYDWKLAPDSDLTSLAIGLTKRINPKLKLLFRRRNEEFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USI9</accession>
    <name>A0A7D5USI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MDN1</name>
        <name evidence="12" type="ORF">G6M90_00g015040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985973.1">
        <property type="nucleotide sequence ID" value="XM_066129766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238465"/>
    <dbReference type="KEGG" id="mbrn:26238465"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4707"/>
            <end position="4909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4044"/>
            <end position="4075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4114"/>
            <end position="4619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4135"/>
            <end position="4153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4194"/>
            <end position="4216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4217"/>
            <end position="4230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4248"/>
            <end position="4301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4312"/>
            <end position="4325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4332"/>
            <end position="4349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4354"/>
            <end position="4363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4376"/>
            <end position="4387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4415"/>
            <end position="4427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4428"/>
            <end position="4462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4477"/>
            <end position="4491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4509"/>
            <end position="4529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4546"/>
            <end position="4573"/>
        </location>
    </feature>
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        <location>
            <begin position="4575"/>
            <end position="4587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4588"/>
            <end position="4611"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="4918" mass="550461" checksum="ABD73C35C13D5E60" modified="2021-02-10" version="1">[encoded data, 4918 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USQ2</accession>
    <name>A0A7D5USQ2_9HYPO</name>
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            <fullName evidence="11">SRP54-type proteins GTP-binding domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g024940</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GLYK kinase family.</text>
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        <property type="protein sequence ID" value="QLI65599.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="URIDINE KINASE"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0418">Kinase</keyword>
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    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI65599.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USV4</accession>
    <name>A0A7D5USV4_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g025120</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="136" mass="15031" checksum="DBA2701CC6253A32" modified="2021-02-10" version="1">MEELPKAHGRSLRAGYSPLHHAAAIEINRMVPPSLEAGGFMSVDSMYTQCTNFPPPLSSASDTSREIDRPANLDMEDSRNAPGWLPAPSWQSNWQRNGWDYGLADPFWSLCPFSPTTGSSRDNIGNSSSLSNREFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USV9</accession>
    <name>A0A7D5USV9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g026950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26237335"/>
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="187"/>
            <end position="325"/>
        </location>
    </feature>
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        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
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        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36382" checksum="06ACC7D815A5CDB7" modified="2021-02-10" version="1">MEQVHPQPASHVLETPIWMMIVRGLQFLISLIILGLAGALMHDLYLDEFGLSVATAILTWCILFYAVFTEKIPPWRTAYHVLAVMVLDGFLVVMWLATFAAVAARRATFKFNVQVGGCIDDGSIIGSKTCFTRRQLERRDILFKSGGEMMSSIAGLGALLWLMFIATFVWTIVMFLRGRKEGRFPIAPGGGGGSNNYQMEPKAEQGASVTQPQQQQQYTPYQQPIQPQQTGQHEQSPLGQNPTPAPYQPAQSPYQQQPPYQPPQDAQQYAQYGQTYPSYQQHVQQGSELSATPLPQQPYSPSPVTSSPPPQQEQQYYHQPQQHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUH3</accession>
    <name>A0A7D5UUH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g048860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544997.1">
        <property type="nucleotide sequence ID" value="XM_014689511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUH3"/>
    <dbReference type="GeneID" id="26242338"/>
    <dbReference type="KEGG" id="mbrn:26242338"/>
    <dbReference type="OrthoDB" id="4203839at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="747" mass="82709" checksum="0AAC2EF1E4433AC4" modified="2021-02-10" version="1">MTGSEGQSVYESADLVALLRKQLENEQPAPYQGGSMLSVDFSSPLGGAARAERIRQMSHNHVRFAPNLSHETAAHVSQQPAFEKSRFAQEILVKIQHSLRRMPGVSSSESGEIVGQLQEVGQVISQETSQLVDALMNVTLDQEDTDKAVARLSLDATILNAEMDDKAQTIRDLRTELDAERKKREQAELDVKKVMGDLQRLREDFKKLQEKATRKDEGADADVRDDIVKSLEDSIRYLEDQVNNRRSLWLMKHSDPQSVARAIETLADSVQDNQAAHQSILSMKSRTARGANNYQDTRHQENADARPYGEMAPPPRPPSVFQAPSTSCAVAPPKFGPLQAGPPRAPSAFSHERRYQGSASSWSSAQGRFAQAGNPFFSNAASSFTRPPTRRPYQAPTRYQPTAAAEFQPGYAPEHAPARPGTAFGHHQPPREYYPQTPTTSRSRYGRPAEPSMSEYGSAPSSAGNAAAARGILSGPLVHMNEQAVAAWNESIMELYAMIRAFVERHANVPDPAMAMKMSTLPLWPVLLATYHPLSAKEAASYLDIHLRADNPKCCLVTRVIIDYIVNRVWVPNAWIGSNDDCTYALLELEKDLEKTQGQPSAQRQPLLDRQAHILEAIIKLEPLAFHREKVGDITTALMATIQPLLNRLANPADAYRDLELVADLAWDLSSKILASRLTFDFRFPEVGARFSSQSMLPIWPALEPTELQAKHWRVALVTTPVVTCRNDTGSNISAHSVALADVYCMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUN0</accession>
    <name>A0A7D5UUN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g013750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549147.1">
        <property type="nucleotide sequence ID" value="XM_014693661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUN0"/>
    <dbReference type="GeneID" id="26238591"/>
    <dbReference type="KEGG" id="mbrn:26238591"/>
    <dbReference type="OrthoDB" id="5222339at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35024" checksum="4D8A2EB8311C455E" modified="2021-02-10" version="1">MTTADANLIIPVPWDKLLLWVQQQIALEMKTGQPVAMTRPQLEALSAFVPFNVEPDVSDQGYVSKLIEKVQSLRLANPVWTDQGPTSIPINGHFQPLWRCVCTLQHHGSFPREGFGFSVGEQAPFFQSKKNAKLFAAKHALSYLTQARPAAITPGKLLRMDRPAISPLQLPKPHIPPPLNVQPLGKRQRLSGNSPVPEATPSKSLRTSVPSTRSPSNPSVFEEVTSLSHRLALGSPTYKIEPDPAGDSLFCGRPVFKNDMRIPPDLGIVSGIAGESQARLKVAESVLEWLQAELQRRQDTFESLWSAANSPKPATPNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVF2</accession>
    <name>A0A7D5UVF2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Negative regulator of mitosis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bimE</name>
        <name evidence="8" type="ORF">G6M90_00g044340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547768.1">
        <property type="nucleotide sequence ID" value="XM_014692282.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240331"/>
    <dbReference type="KEGG" id="mbrn:26240331"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000283">
        <property type="entry name" value="Anaphase-promoting complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000531">
        <property type="entry name" value="Negative regulator of mitosis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="7">
        <location>
            <begin position="1031"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1904"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1905"/>
            <end position="1922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1957" mass="217697" checksum="EF1516FCCEDF874B" modified="2021-02-10" version="1">MASVRSLGLHHPSGLRHAVEEQLLPQSPPPSAYNWEITSDDKGDEAQEDELLATQDCVVWCRGGIFRKTFKFGLEKEPITQALLAYFATSEDALHNENHNSGPPTKAAALAAPKLDKALVVFLKTQAHIFFLSGTSHVIHMPFEVESACAGPIGVVIQRKHKAENLAPIALKFPRVPPNSFVSSQLTALNSSQQTAFSVEGMGKPKPLHFGPSSTLETMWDMPSEQQQLSHWPRLVSLMDPLSDIGLVVGEPEPYSRRPARQNKSKKPAFLDPAEEILHIEQINLPGSDCRAFDAPLILAVTINRENGSYTVWRLKYLEHEDPFIGQQKKAKNRTSRRRSSMPPQGFTSGTSTPVQQNYRESFGAPLPGKRQRKSEKAEKPLDLVSSLEQQDNEGAGVTRRSSRRLSSMLARADLSASHERSVFADQPLTSSTGASKRIESHNGHHGRSSSSFHHIHPSLGSLLEAPLAATLDEGLHNMGLDDHDFDGLQNEIRFTKIQTIALDSSNVRYSTSTLPARCQTKVFIVTAPPFATDEQGRTQLLIGIQEPLEKRLQMMTLHVKAQEKSDPATTASGKDQSRYSIVSISPGTQWKVQSVVDSSKLVDGDLSVILVLSDSDDGQHELTAQAPWIELTKISLSLLFVDDTRNIQYRGRVADRDVKQRKSEVMDLTSGGIVGIRHPRNCGVVDVVDAHGRLHQLRIQLQPSCPQVKKVLDICKSVLPDALGGRLHAGWLHMTQWLQNHQDNLPNVEWSATTVLLLSSFLNLGREDDSPFKTSQLPVRKRRPLSGSFSAIRESEDWRALELGETTNSLGCPAWMMNQGWQWALEEETADNASDQSDALLSSKFLTRHIALSKEYLSSPLGEAAMGRQGYMPVSLARSSATRRKVAVDIFMALHLLLDEEKLDITTPEYVSPGRTDLRVLLCQLARWLKWQTFVTIYELGIQEDVDTRHDLELNLRPAIPQPPVRPDILEWIQSRLSGIRGKPCMTPADIYYASSRVSEAEKLQDKRWDAIATRTLMFKRFFKIIRPKSTAVEMVEAMQDCGFTNYILETLPEAVLAPLQDAISLCQPHPPSQWPHHLLDLVRRSDISLIVKPSRRPRQSVANILAPTHMASWDFKMLCQSVEEANNTGYDEGEGTERQAVIRALFKDDRRLNEAQHLLSTHKARVVRLNPDPSWPESEYLEKQKELVSRIATGTLAIPAGRGLLYYSLRFPLITQKFHIGGFNLNCIVKPTNVTVGVDKSLFTEEKVCWGFFHQGVAAGLAISPQAKGIDTSWILYNKPTQELSNRHAGFLLALGLNEHLKGVAKWVAFKYLTPKHTMTSIGLLLGLAASYMGTMDSLITRLLSVHATRMLPRGAAELNLSPLTQTSGIMGIGLLYCNSQHRRMSEIMLSEIEHIDEEDEEEPLRSECYRLAAGFALGLINLGKGGDLKGLQDMKLTEKLIAHATATKNVEIVHILDRASAGAVMAIALIFMKSEDQIVARKIDVPDSVLQFDYVRPDILLLRAVTKNLILWSKIEPTLTWVRDSLPLPYRARYKLLGTTKLRSTDLPFFSILTGICFSIALRFSGSASTRARDLLLHYLDQFIRISNIEATPRSHPDAAPLYDEELARSNARMCQDILALSCSIVMAGTGDILVLRRLRSLHGRDNPDIPYGSHLAAHLAIGSLFLGCGTVTFGSSNKAIAALLISFYPIFPSNVMDNRSHLQAFRHFWVLATEQRCLVAKDVLTGQPVSVSVQIKKKQDSSSEHILYRTTPCLLPPLDQISSLSTSCGPRFWDIELDFSNDELRQAFAQTQSIYLQRRPPSEGAFTSTLRTLGSDGKGNNPLEWIFGLGKLRSVSYAERAALMESNEKEQDAGSAVDARMEMERGILQGGDRERLEGARLLFEWGAARERLLRSAAPSVHDSQATVRPGDSQETIGEQVTPHAPGGDVWWMRDSAIEALKGQVWLAVRDGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVF5</accession>
    <name>A0A7D5UVF5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g034070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543334.1">
        <property type="nucleotide sequence ID" value="XM_014687848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVF5"/>
    <dbReference type="GeneID" id="26244135"/>
    <dbReference type="KEGG" id="mbrn:26244135"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="273" mass="29377" checksum="97A54AE05DF37586" modified="2021-02-10" version="1">MVNPHLSLGIAQAVFYLPMLPLTIWLMIRNGKIRPRMAWWPLIPFTLMRLAGGPVIIAMVANMEQHNGEPDIGLAVAATILLNVGVIPLIVADLGLTRIILMDNFGDGPFTHRITVGLRLTFVAAIALLGAGGGIGSQPDPDLVHTGHNLVLAGYIVFAAELVALTLMQVYYHARKSSLRPSGHQVLRGALLASPFIMVRTVYGLIESAHAQETETLWNPVFGYPAASSTVLFALMALVMEYIALLIYLWSGFSIAPDRGLGGSRDAGPVPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ5</accession>
    <name>A0A7D5UVZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrG_0</name>
        <name evidence="12" type="ORF">G6M90_00g033280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986319.1">
        <property type="nucleotide sequence ID" value="XM_066130124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ5"/>
    <dbReference type="GeneID" id="26244058"/>
    <dbReference type="KEGG" id="mbrn:26244058"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="274" mass="29931" checksum="BDC6C9ED0CF26747" modified="2021-02-10" version="1">MASQSSKTYAQRGHAHQHPVARKLFEIAELKKSNLVVSADLEETESLLQCADDLGPYIAVFKTHIDVVRDFGDATIHGLKTLAKKHNFMIFEDRKLVDIGNTVQKQYHNGALRISEWADIVNLSILSGDGIVDALTQTVTDPGFPFRGERGFLLLAEMTSRGSLATGSYTSQCVRLARRHPESTFGFVATRALTAVQPRDGGPDEDFVVFTTGINLESRGDKLGQQYQTPAEAVGRGADFIIAGRGIYAAGDAVAAAKRYRDEGWKAYLQRVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW19</accession>
    <name>A0A7D5UW19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986329.1">
        <property type="nucleotide sequence ID" value="XM_066130343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW19"/>
    <dbReference type="GeneID" id="26240321"/>
    <dbReference type="KEGG" id="mbrn:26240321"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="114" mass="12984" checksum="9A441F0EAF881110" modified="2021-02-10" version="1">MATREAGEDLADNHHWPLPVHKDDDDSDEGQKDWLSDDLDDSIETDFAETDYEGDQDIFMQQEDDELSSLEDEEDADDLTEDDFRDEALTDIDSDDDSVGCEDLMDVDECGQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWC5</accession>
    <name>A0A7D5UWC5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g047430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544861.1">
        <property type="nucleotide sequence ID" value="XM_014689375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWC5"/>
    <dbReference type="GeneID" id="26242202"/>
    <dbReference type="KEGG" id="mbrn:26242202"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="511" mass="54873" checksum="E9C5B511191D91B6" modified="2021-02-10" version="1">MSSNPFRKKALGPIDTARASSPRSSLRSEDAEAGDRKNKPVKRVRVLSPPPLSPDSPEWPFEAPQPPVPLSDDTYNHSNYYPSFDPFNGASTDESDGESLATPPTDKYQHQPQQQQQQQHDAGSGGIPANPFSKTLRDLEGSKDLQRERKEEGEVLKAANEGRKSLNVDSFKRLLMTGNADDFASSASTDGEEETAKGNALPTAQTNARGRNYTDSGSLADSSHEDEDKEESKILAVKSPASKEKKAPPPPPSSRHGKSLRQREPKDVKDDGHATAEPVRRSMDDDEPRLDTQATNAAEGEADARSQINSIPNLPGARKPAPAPPPPRGHARTDSKSHDNETPPRRTSSEDMPSRSDSTRSAGHAPAPPPPRRPYLAPKQSSSSSPSTSSSNMASSTDHVQDTARSSHDSPTPSKPLIAPPPPPTRQPSTRRPPSVTGVDAPSRRVSSENKSRETVPPPPPPPRHRGSSPNADGRKVSGEASAADPSKSADILADLDALQREVDALRGQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWJ8</accession>
    <name>A0A7D5UWJ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chlorophenol O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cmt1</name>
        <name evidence="6" type="ORF">G6M90_00g060020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544571.1">
        <property type="nucleotide sequence ID" value="XM_014689085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWJ8"/>
    <dbReference type="GeneID" id="26242983"/>
    <dbReference type="KEGG" id="mbrn:26242983"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="297"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="509" mass="57124" checksum="26D52F1C478901A0" modified="2021-02-10" version="1">MAKFKVPSWLQTSTAAEAEKEKKKQNRRSFGGFPQNIRTRQHVPAATRPQAVHEDPKPVAKTQTTETTRLVTLAKRIAAEAEKLEQYLKENDLPQPGFGSDAPGDFPNLPPEIQKSRQDIVYATRELGTLVRGPRESVRWGVWSYLDTLSLQIINNYGIAKLVPLNTPIPLSDLQEKTTLDPINLARILRHAMTNYIFCEPEPGLIAHTAASRKLAEDGALQDWVGFNSEDIFPSAAKVLKSLKEHPEATSLTTTGFNYAFDTVDQEPMFVTFGKDPARAKRMGGAMASLTGGEGYEVRHFVDNYDFSQEDERGGTFVDIGGSHGFVSVDLAKKWKNMKFIVQDLPKTVSSAPKPISDDESVAERIQFEAHDFFKEQPVKDADVYFFRWIIHNYSTPYAVKLLKNLVSALKPGARIVINDHCLRESGSENPWDEKLMRSMDMIMLTLLNAQERAEQEFRDLFKAADERFVFKGVTRTPGCRMSVIEAVWEPTKPTANGTAKHADSESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX73</accession>
    <name>A0A7D5UX73_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitination network signaling protein acrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g045330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986603.1">
        <property type="nucleotide sequence ID" value="XM_066130369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX73"/>
    <dbReference type="GeneID" id="90967692"/>
    <dbReference type="KEGG" id="mbrn:90967692"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="982" mass="107598" checksum="00A58DDA3C971BCB" modified="2021-02-10" version="1">MPRASGPGKRQQGASSGHRDSKHDNGLVSPAKRNAGRKSHGHQLDGSARPPDHSAGHAGPSPSPPLLPLHAAAHPHASSTKSNSDAAIDTRSADFTRRGSLGTFSETSSDSCPSQAGANGNTPIEPGHRQIDLNAMKNVDVHKDSGPLEMAVTVVKSLPMQDTLAILIILMHVPHLSLSLIYAFFALVTFVPPVTTRTGMNINLAEILDSHSHTLNFVTLLCIDFFFFLIWVFLWQPIQDGILEFAKPVIAITLGGGTNAKDGTSRGVTTCFTWILLHQTIRATRSHWAKLARHLPENWPLPTLLTQSLEPRSVAYDKRSTHEWIQSILAMHILTQGIVRYVREWYLKREKYNAASGLSDPEAGKSSSLGNSSGSLGGGHQNSSQSLESSNDAGLAGADADASVPHPPTSTNLTTTKKRRKQNAQVRLQQPLWAAVASTKIVVMKEMELSKSVRPDGIVNIHTNEGTTFEKKDRQIWISYIGSDEVCFNTSYFSDSKTDIPQEPMKSNGHVKTTRPSGVDSSKPFYVRINNAFWQPTRIFPIDEVDEDDEDKDGKRGKRIRWTGDIYGLRPASKYVCEFVDVETGAVIFSTSIRTVKELLREDDSLSPVFPPSQQPLRPDSPATILRTSIAASEAKLAEEKSRLRTLRKDLKIKINAVRKENELVDNQLSSAGNSDEKHKQKIRQQETQKAQAERDTESLTGELKNFDTAPELFERKKKMERTYAAEKKTFDAEQKEFKKHKSSLDAEVKTKELEMSNLNTRRNKIATRISRVETELNHITDANNRGLGEAERRNQQRALWLSHAASIEHNISERLSVVHGNNRAKMRQYQLLQGQTQAYSVYLNSANGMPGDDGPASGAQPATWNPNPVVTPNYPPGMWPVSSSDLIPPVAALSTHASAPGWQPPPSAPPFEPRGARSRGRSSSMLSDLSGFTEPSDEGSVKSPPIILRRPGPGLLGRNGTSGGSSASSGSASFGDPASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXD2</accession>
    <name>A0A7D5UXD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oleate hydroxylase FAH12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAH12_1</name>
        <name evidence="3" type="ORF">G6M90_00g052360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540366.1">
        <property type="nucleotide sequence ID" value="XM_014684880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXD2"/>
    <dbReference type="GeneID" id="26246728"/>
    <dbReference type="KEGG" id="mbrn:26246728"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="48450" checksum="701ACF2D1162CE76" modified="2021-02-10" version="1">MTMATTSTTENVTTETKHVLYVPDTYHEEPVRPGYVDGLIGIDGLRAAVPKHCFQPSIVRSLGFYLRDILFMVSLLTLALYLERQIESPVLKFVVCGLVYPFLAGMPATGFWVLGHEAGHGSFCKNRLVGDFFGFTAHSFLMSPFFSWRSTHSRHHVYANHMVKDHNYVPPRRHEYSELFKPKGDFELREMTEDAPIVILARVILQQLIGWPWYLLTNITAGSQAVRRPSHGWWNNSHFDPWGALFRAEEFWSIVASDVGIIAMSYLVYKAACVYGWWTITWTYILPLMWVNHYIVIITYLHHTSPCLPKFSPESWTFLRGALSTVDRDPGYFLRHLLHHIIDLHVVHHLFPRIPHYHAQEATDALRPLLGKYYHQDKGSYYGALYSNFRDCQWVEPNPSSEWIENVPKVSRIDLLKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXL5</accession>
    <name>A0A7D5UXL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g054300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540974.1">
        <property type="nucleotide sequence ID" value="XM_014685488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXL5"/>
    <dbReference type="GeneID" id="26246280"/>
    <dbReference type="KEGG" id="mbrn:26246280"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="41"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="45027" checksum="C2B01EF02A7369C5" modified="2021-02-10" version="1">MASAGLPPPPSGIDLSQDKRPLIVAISVTTWILAFTTVACRIVGRRMRGLQLWLDDWFIVAALPPSLGHVLGMAAYAVSHGLGRHVWAAKRDCLYAWALGLFVAEICYTLTLVFVELSILSFFWRSFSVRDSIQWPILILASLVCIWGAAVLLVTFLQCLPTRAIWERFDPANSMSANNYTCEVDLVKFFYANAIPTIVTDLVMLMLPVPYVWRLQLPRIQKIALGCVFLAGVFVTIISMIRFYHLLSLDLEDPDITWNFVTVGIWSFVEGNTAIVCACLPFLRPVINRIPCGNPFILAPVPLNIVQQSEDSGRGFNQKNVFPTWGFNKSHAASTAPVQSLHHDELDNDEYPFAHLADDVSETDTPARRDDRAFVDLEAVVAIPSARYIPMTRDVRQPHQATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXV5</accession>
    <name>A0A7D5UXV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Atrochrysone carboxyl ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TPCB</name>
        <name evidence="7" type="ORF">G6M90_00g052590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540386.2">
        <property type="nucleotide sequence ID" value="XM_014684900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXV5"/>
    <dbReference type="GeneID" id="26246748"/>
    <dbReference type="KEGG" id="mbrn:26246748"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF3">
        <property type="entry name" value="ATROCHRYSONE CARBOXYL ACP THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="41073" checksum="3F965597B1A9EABC" modified="2021-02-10" version="1">MFFSAKSITKSFLEPQLSRNLPDTLDEMVQDINTAVMQADKGGYRQINKSLNICAFEDYLQGQTTNLPKLPNVEQLTPRVLRILGQNPGKFTYQGTNTYVIGTGTHRLIVDTSGGEPAWAELVSSTLESMGVSLSHVLLTHWHGDHTGGVPDLLRLYPHLEGSIYKNEPDKGQQNITDGQVFRVEGATIRAVHVPGHSEDHMCFVLEEEQAMFTGDNILGHGTSAVEDLGIFMASLQKMYMQNCPVGFSAHGVTITDLPAKLKKELDGKLRRERQVMQALGRARTRGERSITVQGLVTEIYGEALEESTRTLALEPFIDEVLRKLAGDCRVAFEIRGGKKKWYSVEAMPQNAGGLMPGPMTASRADARVQVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXV9</accession>
    <name>A0A7D5UXV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Golgi apparatus membrane protein TVP18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TVP18</name>
        <name evidence="9" type="ORF">G6M90_00g037500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547111.1">
        <property type="nucleotide sequence ID" value="XM_014691625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXV9"/>
    <dbReference type="GeneID" id="26239674"/>
    <dbReference type="KEGG" id="mbrn:26239674"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16005" checksum="220644A0E36EC1F7" modified="2021-02-10" version="1">MSLKEEFQTRNFSIYGQWLGILSMIICLATGISTIFTFKVVLIIFAAIAIASSFLILFIEVPLLLRICPTSGKFDDFVRKISTNYMRAAAYGIMAFLQFLSNLGGPSSLIAAGVFLTLTGICYLLAAIKGQAFVGSKTLGGAGVAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXY2</accession>
    <name>A0A7D5UXY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrotransposon-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RTL1_1</name>
        <name evidence="2" type="ORF">G6M90_00g066550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539369.1">
        <property type="nucleotide sequence ID" value="XM_014683883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXY2"/>
    <dbReference type="GeneID" id="26247847"/>
    <dbReference type="KEGG" id="mbrn:26247847"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="84"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="25968" checksum="ECC006BFAF91CDAD" modified="2021-02-10" version="1">MLAEIIRLQERVQQIEEERQEQATTTTTIKKDLGEILKPRAPGPYNGSPGALQEFLTQLRAYHQQFPNKMEESSVKVLHTGGCITGVALAWFEPIIRDYLNKEKDNRKEETNTIFESYDEFKKAIKKAFGTVDEARAAEYYINGLKQKGSASDYTARFRQLASQLNWEDEPLMSAFYKELKEEVKDKLYKENRPDNLSDYIAMAVRIDNKQYQQRIQKKQGKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY84</accession>
    <name>A0A7D5UY84_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545309.1">
        <property type="nucleotide sequence ID" value="XM_014689823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY84"/>
    <dbReference type="GeneID" id="26241342"/>
    <dbReference type="KEGG" id="mbrn:26241342"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="47801" checksum="C9319E793919BA02" modified="2021-02-10" version="1">MARFFDLEEEGDDGASHPPEDLITQTLQSKSQPQNKGGQLATAPAATSHCSESIARAFQCYPIISSIVSSIDLNTLDSLARSCRSVHDGLIQYRNVLVTSTLHCTNEQVPLNPEELLRYRARASNWHYMEDGRNYNGKSGTCARDMVDECRKCGEVICRNCSIKPPAPVALRERHRRLCRTCIKAPIAALAIPRLDPELPFGSDAVQQSLCKCEKAGVWLCQPCGRSIRAADHEYRSIWRWRNQYGEVLGGLGTGIGDGDRGVICGRGEECLAAKDREQETDCDAQDARESGTAPWVNEPPVWTTTSTPSPPALGVSDSPAGSPFGPATPLGALIEEERHERTPSPQLGPGYERHEIEGIGGRVKRKLVRMVRIGACVPEWDDEKGFGGRVLESEIKGCARSWCGWCWRVIPGKKDLHVDKASSFSGCENRQCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY89</accession>
    <name>A0A7D5UY89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosome biogenesis protein Alb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g065270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540247.1">
        <property type="nucleotide sequence ID" value="XM_014684761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY89"/>
    <dbReference type="GeneID" id="26247056"/>
    <dbReference type="KEGG" id="mbrn:26247056"/>
    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19007" checksum="01A76EFF2DC295F6" modified="2021-02-10" version="1">MAKSKGPSKHSRAARRATSPSIDTDKSLKDIPLPKRSTSSAPRPSVLAVHRAAGISKKSKPVRKSRLTSKMRKRHEKGLEMAEAVTERTGKKIEQSIGRAKNVQRRSRTWEDINKDAVEGGAGDEQTGGSRFGALMEEADDDDDGDAVEDEDGFNPANPGASKPAAITDDDDDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYD0</accession>
    <name>A0A7D5UYD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Squalene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g052610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986881.1">
        <property type="nucleotide sequence ID" value="XM_066130547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYD0"/>
    <dbReference type="GeneID" id="26246750"/>
    <dbReference type="KEGG" id="mbrn:26246750"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33046" checksum="3006B00803661C2D" modified="2021-02-10" version="1">MFHNVITEFKKIKPAYQAIIKDITSQMGNGTADFVRKAASGDVSIKTLEAYDLYCWYVAGVVENAQLYKSMGLLLQKNNITRDVREDFDDNRCFWPEEIWSKHVDKFEDLFKPEYLDAALNCSSEMVLNALLHTCYCFSYLKCLHDQSVFNFCAIPQSMAMATFELCFRNPAMFQRNIKIPKGDAFQLMIESSRDIIVVCAIFRRYSIRIQQKNDPADPNFAEINKACEKACTLTSYADTIGSQQAGKMLVVGTRRAQGKWSNPQLAFASVAITSTLILGAALVMKGQFEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ24</accession>
    <name>A0A7D5UZ24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RPC1_1</name>
        <name evidence="16" type="ORF">G6M90_00g070450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540633.1">
        <property type="nucleotide sequence ID" value="XM_014685147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26246506"/>
    <dbReference type="KEGG" id="mbrn:26246506"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="259"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI70794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1447" mass="162076" checksum="3E19C787AD89FBAE" modified="2021-02-10" version="1">MIHSTEGPVKQQLEDKLPKRFKGIKFGIQSNQDIANQAVLEVSDRLLYDIENNRAPYRHGPLDPRLGTSSKSGKCDTCHDSLQNCIGHFGHVRLPLPAFHIGYLRFIMSILQEICKDCGRVLLEEPERRSFLKELRRPMDNLRRTQICKRINEQCRKSKTCPYCGSVNGQIRKIGVLKLTHDKFSFYNKSTAAKKVPPESKVKFDDSFSQAKRENPELEKHLRKAMEDLNPLRVLNLFKMISPTDCELLGLDPAEGRPEMFIWQFVPAPPVCIRPSVAQDNASNEDDLTTKLADIVWVSGMIRSALQKGSPIQTIMEQWEYLQTQIAMYVNSDVPGLQQPGFGKSTRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLGIDQVAVPQLVAKNLTYPEKVNRQNIEKLRQCVRNGCDVWPGAQGILKKEDDSYYKFNLRFGNRDLAAKQLSYGDIVERHLEDGDVVLFNRQPSLHKLSIMSHLAKIRPWRTFRLNECVCNPYNADFDGDEMNLHVPQTEEARAEAINLMGVKYNLATPKNGEPIIAATQDFITAAFLLSSKDRFFDRKSFSYICMHMMEQGTKIEIPPPAIVAPKALWTGKQIFSIMMRPNKDCSVKINLDAKCRAYKARPGQCPDMDPNDGWLVVRNSEVMCGRMDKSTVGSGKKDSIFYVILRDFGPDEAVIAMNRLAKLCARALTNRGFSIGVGDVFPTETLNVEKENLVSTAYKMCDDLIETFKQGKLDKAPGCNMEQTLENSISGILSKVRQQAGSYCIDTLSRNNAPLIMAQSGSKGSDINVAQMVAVVGQQIIGGQRVPDGFQDRSLPHFHKNARQPPSKGFVKNSFYTGLFPTEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSTQYDDTVRTSGGGIVQFQFGADKLDPVDMEGSAEPVNFKRTWSHAETLTWDNEEAAMTPSEIRAFCDSMLAVERKRFPRHGLAYGEKLDYEDTTDYGIDEHEGARRFLKTIENHVEGLASKLEKVRKLAGFDGDKMLRATAQDHADRTAKVTATTLRLFIKMCLEKYKKAHVEPGHAVGAVGAQSIGEPGTQMTLKTFHFAGVAGMSITQGVPRIKEIINASKNISTPVITCPLMNDKQIEAARVVKGRIEKTYILDVLHFVEDEWRPDEGNVVLQIDRSALSDLHLGIGIYDIAESICKQRKLKIPREDLSVYGERIVIRVRDASDMPARKTTRTKPALEDSGDMLLRANFLRRALPHVPISGYSEATRAIIQTSEQNTHMVLVEGYGLRECMTTEGVIGTQTRSNNVMECRDVLGIEAARSTIADEISQVMGDMGIDPRHMQLLADVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTPDHLFEAAAGMKTDQIEGVSECIIMGQTMAVGTGAFQVVRRLGIRPGDMAQKKTLFEDAWNSEVRGKKKVRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZY3</accession>
    <name>A0A7D5UZY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g073220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987189.1">
        <property type="nucleotide sequence ID" value="XM_066130980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZY3"/>
    <dbReference type="GeneID" id="90967943"/>
    <dbReference type="KEGG" id="mbrn:90967943"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000080">
        <property type="entry name" value="Aminotransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="45"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="466" mass="52009" checksum="F8C50FB6A8FD48FF" modified="2021-02-10" version="1">MESYLLSGRNHINLMRGWPSPDVLPAAMLSSACQQVLLRRQEYIPILQYGPNTGHPTLKNELSRWLGEHYNVSPDPSRICVTGGASQSLACILQSFTDPNYTKAIWIIAPCYYLACGIFEDSGFAGKLRAVPEDDEGIDLVVLQNKIRELEQDEQAKPQLKPVKPHDTTRKLYRHVVYIVPTCANPSGKTMSLRRREELVHLARDHNALVVCDDVYDFLQWSVDPEDEQGNRSDLRLPRLCDIERSLGFSEQDPDEFGYTVSNGSFSKIAGPGVRTGWVEASSKFVIGLGNTASTLSGGAPSQLCAAILGETLRTGELQKHIARTVCPSLQRRYKLAMTAIHQYITPLGYRARETSLTGARIYGGYFVWLSPKAELSLCSQLVADVAMEEENLAIGYGCMFEVHGDDGSAPFKGDIRICFAWEAEDALIEGIQRLGSLLKRMLENPAQYENWKSKTEESSSFVHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0E0</accession>
    <name>A0A7D5V0E0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ETR1</name>
        <name evidence="14" type="ORF">G6M90_00g091570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541805.1">
        <property type="nucleotide sequence ID" value="XM_014686319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0E0"/>
    <dbReference type="GeneID" id="26245273"/>
    <dbReference type="KEGG" id="mbrn:26245273"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="60"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="45450" checksum="D49A29EF8C553B42" modified="2021-02-10" version="1">MASRQCLQSPSLVFKLSRPTSSLQATHLNRLPRTALRRKSGPYGYTQSKALVYSKHGEPSDVLKLHTHSISPSLPSSSVLVRTLAASINPADINTIQGTYGSKQPMTSLIGTAEPSAVPGNEGVFEVVSVGDSSSPLNKGDWVIPAAQQIGTWRTHAVFEAGDLLKVDRENLTPTQVATVSINPCTAYRILRDYGPSAGLKSGLPMRPLQLGSGEWFIQNGANSGVGRAAIQFGKLWGLRSINVIRDRDSVEETEALKQELIGLGADVVVPESQFLSREWKHQLADITRGGREEIGLALNCVGGKSATSLARSLGEGATLVSYGGMSKQPVALPLGLLIFKDIRFVGFWLSKWNKKDATGRKHMVNDILNLIRLGHFKDVPVDEVKWDWETEEAPLKDAVQEGLKGFRKGKGVFVFGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V108</accession>
    <name>A0A7D5V108_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cwc-24</name>
        <name evidence="10" type="ORF">G6M90_00g089280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987344.1">
        <property type="nucleotide sequence ID" value="XM_066131350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V108"/>
    <dbReference type="GeneID" id="26245454"/>
    <dbReference type="KEGG" id="mbrn:26245454"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="4 5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="340" mass="37154" checksum="C58F15A9ECFD3B2F" modified="2021-02-10" version="1">MDSNDAGAAIEANAPVALFKKRGPKGKANIRKRPATPPPANSDSDSDYTSSEDESGQRVKRRKKNAAVTVSSKDTSTVAKDLNATVFKANRDLPISSSNDATKQSNWYDDGTKDDLSAKNLLGSSKSTAKPSQADGTYKGLANQTSFIQKNPDAPKKTVGPIKAPTNIRTITVTDFAPDVCKDYKKTGFCGFGSNCKYLHSREDYKHGWQLDREWDTVTKGKKSLGGTVVASAKRDKTDGNDDDDDDDDTLLQNIPFVCIICEESYKSPIITRCGHYFCEPCALKRYRKDPTCAACGAGTNGVFNSGKRLNKLLDKKREREAQRRQAALEAGEEVSDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V172</accession>
    <name>A0A7D5V172_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539444.1">
        <property type="nucleotide sequence ID" value="XM_014683958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V172"/>
    <dbReference type="GeneID" id="26247763"/>
    <dbReference type="KEGG" id="mbrn:26247763"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="167" mass="18408" checksum="B2A2DB1C0E514DA1" modified="2021-02-10" version="1">MASVVTGAGLFASFRKLATTDYFVLLALCMSIATLGIETIKDSQGESAHYMTLSEWAAAQRIAADQIMSWWDVTGRKENDMAKIIESETPFTPNPQHNGAKYTSIGFRFLENIDDQHVAAHTNLLKAQGEWLAECKGSSGRNGTRPYRLSPTPVASSIQEPYAEAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V189</accession>
    <name>A0A7D5V189_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter prlL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prlL_6</name>
        <name evidence="8" type="ORF">G6M90_00g090400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541699.1">
        <property type="nucleotide sequence ID" value="XM_014686213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V189"/>
    <dbReference type="GeneID" id="26245562"/>
    <dbReference type="KEGG" id="mbrn:26245562"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="34"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="491" mass="54202" checksum="C279897F767404E7" modified="2021-02-10" version="1">MSSVPSLDVPGLESVDISDKAMERRIVRKQDFRILPWVVVTYLLNYLDRVNLGNARTLNNDTPEDNIVVQLNLTGQRYNVAVALFFVPYVLMEFPSNILLKYFSPSRWISRIMVSWGIITICTAAVTTYGGLLAVRMALGLAEAGFFPGMMMYLCFWYKPEERATRMAIFATSVSVAGAFGGLLATGISFLNKKAGLSGWQWLFILEGIPAVIVGVMVWFYLPDYPQTSSWLTPEERAFAVKRLGPYAPSMGDKHWDSDVAKKTLIDPWFWLFAAHYFLMTNSLNAFGYFAPTIVAALGYKGYEAQLLTVPPNVVAMVIVIGTCIHSDKTRERPRHILGALGFLATGYLLLAVVSQRGVRYFAICIIACTNAAVLPFVAYRTATVQGSTATALATGGMIAIANCGGISSPFLFPSSDSPMYSRGNWTIFAFLMAAALLTIYMWYKLGSHAAYRTGERDDEGNMEVLDATPSNANDRMNKAFGISKLNDVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1A4</accession>
    <name>A0A7D5V1A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g087370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542381.1">
        <property type="nucleotide sequence ID" value="XM_014686895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1A4"/>
    <dbReference type="GeneID" id="26244895"/>
    <dbReference type="KEGG" id="mbrn:26244895"/>
    <dbReference type="OrthoDB" id="2349272at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21596" checksum="71EB52864DC45978" modified="2021-02-10" version="1">MALAALANAATEEPAKISAETLTKMMPNQTCEGKSDDCRTPAQAAPFIEKSMARYRINNTNEIAAIVSLMALESGNFTFKHNVFPGRKGQGTANMQMAEFNLEYAKSIPCLQGKVANITTVNNATNATLDYILSLVTVDKYNFGSAAWFYTTKCLPDSRTGLQKNITEGFATYMKCVGVDPAGERTTYLQRAMAAFGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1K8</accession>
    <name>A0A7D5V1K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g081420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543381.1">
        <property type="nucleotide sequence ID" value="XM_014687895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1K8"/>
    <dbReference type="GeneID" id="26243558"/>
    <dbReference type="KEGG" id="mbrn:26243558"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="404" mass="45601" checksum="F62284BEE46C90EE" modified="2021-02-10" version="1">MLPDIKPFKIAVPDSAIAALKAKLAKAAYPDQVDFSDDWAYGAARNDVRRLAKHWEDTFDWRAQEQKLNKLPHYMTKISVDGFEPLDIHFLHQRSSQPNAIPLLFVHGWPGSFLEATKILPLLTEPRPGQQAFHLIAPSLPNFGFSQQVRQRGFALPQYAECMHKVMLQLGYDTYVTQGGDWGFFITRLIGLHYPEHCLASHINFPVVRPPPAKSLWFGLQYLLGQYSHTDRQGLARTLWYFAEGAGYMLQQSTKPSTLGFSLADSPVALLGWIYEKLHDWTHEYPWTDDEILTWVSVYQFSTAGPAASLCIYYEAYHARKSSVKCTRYVPSVPLGISYYPKDLFVVPKPWGQCLGPVVYEATHSHGGHFAAFEEPELFAADLQSMFGEEGGARGVAQRLSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1V9</accession>
    <name>A0A7D5V1V9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 monooxygenase FUM15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FUM15_3</name>
        <name evidence="6" type="ORF">G6M90_00g099670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546382.1">
        <property type="nucleotide sequence ID" value="XM_014690896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1V9"/>
    <dbReference type="GeneID" id="26240805"/>
    <dbReference type="KEGG" id="mbrn:26240805"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="543" mass="60511" checksum="61A3FE22113F7EF3" modified="2021-02-10" version="1">MRFWGYEITGFSLLGCAVLVFAQGLRSRLVLAGAFVGFWLGGAALYCAWAVLIYPHYLSPLRHLPTVKGGHWLFGHGQRFATGVDEPTREWINTIPHEGLLRYFWWFNNERVIVSSNKGLAEVLVTKSYQFKRPDIVRRLLSPVLGFGILLTEGDVHKVQRRNLMPAFAFRHIKDLYPVFWRKAREVVQAMSATANSDGIATLDALDWANRCTLDIIGLAGMGVDFGSIQDPTNPLATTYKSLTGTQGQAGLLGILLILLPAWLANRIPLRSNNVIHNANRTIRNVCKDLIRDKKHRMANKERTDVDILSVALESGLFSDENLVDQLMTFLAAGHDTTASALTWATYVLSCYPDVQTRLRDEVRERLPRLDADADITSVDIDKMPYLNAVCNEVLRFFSPVPRTSREAVEDTTVQGYPIPKGSVVLLSPWATNVDQNLWGSDALEFKPERWLASDAMDTKSASSGGASSVYAFLTFLHGPRSCIGASFAKSEFACLLAAWVGRFEFDLVNDEMRDKEKLVVRYGVTARPKGGLPVRARVLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1Y1</accession>
    <name>A0A7D5V1Y1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Procollagen galactosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">colgalt1</name>
        <name evidence="6" type="ORF">G6M90_00g081060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987491.1">
        <property type="nucleotide sequence ID" value="XM_066131171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1Y1"/>
    <dbReference type="GeneID" id="26243524"/>
    <dbReference type="KEGG" id="mbrn:26243524"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="71"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="361" mass="40633" checksum="9360E98F5AD8FF69" modified="2021-02-10" version="1">MGTPRNLLMLSRPTFTMRCGRMPVLVIALVAFHLYLIRAWLENQNWEYGGVASSALLDVSEAAQNETLGFEKIYYISLPHRTDRQDMMTLLAASTNIKLALQPGVNGSNVNDKAKPKGSESLRPEQLGCWRSHADIWQRIINENIQTAIVLEDDADWDVEVHDIFQTLSVQMRKGELRKWKATKYEANHAPYGLDWDLLYIGTCWDIPNGENRPKHQVYNDRFSPSSTEMTDSFRKELEDWGVDLANNTRVRVLAPSWYSVCTIGYALTNRGAQKLLYTIGNRESMGAPIDLAMIDKVQKGYLDALTVIPPLVTPWKTGRVSDSDIDNLAERKGELPSGSENLQNSARKAMENSLLGGQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2G5</accession>
    <name>A0A7D5V2G5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 16">Sortilin VPS10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Vacuolar carboxypeptidase Sorting receptor VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">VPS10</name>
        <name evidence="23" type="ORF">G6M90_00g100590</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546289.1">
        <property type="nucleotide sequence ID" value="XM_014690803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240712"/>
    <dbReference type="KEGG" id="mbrn:26240712"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028949385" description="Vacuolar protein sorting/targeting protein 10" evidence="21">
        <location>
            <begin position="26"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1376"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1424"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="48"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="22">
        <location>
            <begin position="724"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="658"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QLI72878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1505" mass="169160" checksum="1A3BF9B82258AECD" modified="2021-02-10" version="1">MRPGGKAAAAWRILLSSLLWTAVLAKDEPSMTVNTFENPPLNINYFEDSDVVIFEDKIEGNVYRSADAGVSWKRVDSVPDGKVLELIMHPFDKKRAYIITPSKTQFRTEDRGETWTRFNTKALPSKFQPEVMVFNAGDPDRIIFNAMDCDGIFCDEQSMYTTDGFKKTQALRVSTTGCWWAKSSPEFTTGEPETDKSRVLCIVRDSISFFRQEQKLVISDDFFAVQDKHIQEFEPNIEMNKGVTGFLNLAVVKKYLLVATSSPHSDEMALYVSDDTKKWHRAMFPKDDSHDHSHRINQGAYTVLEGTNYSIQVDVMTSHPSRPMGVLFTSNSNGTYFTENIPYTNRNTKGNVDFEKISGIQGIFLVNTVKNGAEVAKEKTDKIIVSHITLDDGRTFSEIKSGDDRLHLHSVTELDNMGRVFSSPAPGLVMGNGNTGESLGRFTDANLYVSDNAGSTWKKALDGPHKYEFGDSGSILIAIKDSDKPDIKEFSYSLDHGDNWKNVPLPKDLSIKPDVLITTQDSTSLKFMLLGERDRTFHMIAIDFEGLKERTCEDKDLEDWHARVDKDGNPSCIMGHKQTYSRRKKSADCFIKKPFEDPVPKTEDCECTDADFECDYNFQRDKDNKCVLAGPIPVPSEECKDNPDGTFKGSSGWRLIPGNTCKRKSGEQKDDQVERKCSEGDTKPSQPPATGEIALKQKIFDFSHDRFEKIYLEKGDASTSTDETVILWPASDGNQIWLSQDHGKEWKQVLKGENVHGIFPHHYFNDVVYFTTDDRKVIYTVDRGQSFHTFQAPSKPKTGAVPFAFHPDRKDWLLWMGETCEKVGGKESCFPEVSVSRDRGDNWKTLRRYAEKCEFTGSSAYKFRDEKQVLCLVNVEERMDSNLTVITSDNFFDDEPVKFDGQVINFATMSEFILLASKDPETGATRAVASMDGKNFEVARYPHNFHEGHNDDYTVLDSSTHAVNLFVRSEAGAGRLYGSIIKSNSNGTSYVVSAANVNSDADMYVDFEKVAGLEGVALINVVTNADNKKETTNTLQTKVSHNDGSQWGYLPPPAKDVEGKSYSCSSAKGDSKCALHLHHYTERDDKQRTFAADTAVGFIFGIGNVGASLGDIKDADTFLSTDGGITWANVKKGHWTWQYGDQGSVMVLVQRATRKNDVKTKIVSYSTDEGKTWKDMEFSESEVTVLDITTLKSGTSRNFLLWCRDNKDKMMTVNIDFSGLADKPCKYNEDSAAESDYTLWGPQHPLQADNCLFGHESKYLRKKTDRKCYNNENLKRLVEFKNCPCKREDFECAYNFELEDSDSQQCRLVQGYQPLSGKEWCSRNPNATSYFDPTGYRRIPLSTCEGGRELDKASEEHPCEGHEDEFERKHRTSGTAIFFAVVIPFTLAGAIGWWVYRNWDGKFGQIRLGDTSSSFDSDRPWVKYPVIAISAVVAVVATLPLLVGGLWRSATGSYSRVRGGSGQSWFSSGNRRFTTRDSFARGRGDYAIVDDDEGELLGDDSDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2V7</accession>
    <name>A0A7D5V2V7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cutC</name>
        <name evidence="3" type="ORF">G6M90_00g096570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546677.1">
        <property type="nucleotide sequence ID" value="XM_014691191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2V7"/>
    <dbReference type="GeneID" id="26241100"/>
    <dbReference type="KEGG" id="mbrn:26241100"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="29366" checksum="DF235EDF33F74143" modified="2021-02-10" version="1">MIARETTQMPLEVAVFSGESALKAQSQGASRVELNAPGSYHVGGTTPPIAELKRIAAKVTIPVRIMIRPRGAPGDGSPDFVYTPKEVAAMAQSIRDFKATGLLNPFRGDGFVFGLLQPTPAEDPLSLPGEPDAACGLRVDDASCRVLLDAARPFGCVFHRAFDPIAATRRIGDGVEALVRLGFEGLLTAGGRGPCAANVDRLDHECHRQAGRIQFVLGGGLRASNVERVAGRFSTYEKGSVWMHTAALSSRPDHPAEEIDSNELVGMLASLGSVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V347</accession>
    <name>A0A7D5V347_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g105450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541532.1">
        <property type="nucleotide sequence ID" value="XM_014686046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V347"/>
    <dbReference type="GeneID" id="26245782"/>
    <dbReference type="KEGG" id="mbrn:26245782"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="37056" checksum="F91E27631E97B37C" modified="2021-02-10" version="1">MAPKGPITTPFTQLLGIQHPVVLAGMAHTSGGELSAAVSNAGGLGVIGGLQYSPDQLRDIIAEMKAAFKQPDLPFGIDLALPQVGGNARKTNHDYTHGKLEELIDLTIESGAKLFVCAIGVPPKHIIEKLHKNGILVMNMVGHPKHAVKALDLGVDMVCAQGTEAGGHTGEIASSVLVPAVVDVARRYKPPMLKGSTALVLAAGGVCNGRGVAAALMQGASAVWVGTRFVASVEANSSNEHKQAVVDCDFTGTERTLVLSGRPLRMMPNDYIRRWNKNPQEIQSLCDRGIVPVEHDLENGAEDIDVPHFMGQVAGSIQRIQPAGEIVHELVEEAAEMLRTGGTYLDGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V354</accession>
    <name>A0A7D5V354_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g095060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540863.1">
        <property type="nucleotide sequence ID" value="XM_014685377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V354"/>
    <dbReference type="GeneID" id="26246476"/>
    <dbReference type="KEGG" id="mbrn:26246476"/>
    <dbReference type="OrthoDB" id="5407645at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="203" mass="22722" checksum="A62A8797E8F02AE2" modified="2021-02-10" version="1">MPNRHGNTYAEYYNDEDYRPSRSPSRLNQVVHGQSHDAKEMAKSAFASHASRRQAEPYEYEAYSDRRTRRHHDYAPGNGHREADYYRHDGHHPRRGRSLHSEERYVGGRRDHSHHRRQPGARSHSENRVKEAATAALAAGLAEAIKSRHSRDQSRRAITAAAGAAAVDALVSNGEDGKKGRRIAESAVGGLLIDRLANGSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V364</accession>
    <name>A0A7D5V364_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541092.1">
        <property type="nucleotide sequence ID" value="XM_014685606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V364"/>
    <dbReference type="GeneID" id="26246081"/>
    <dbReference type="KEGG" id="mbrn:26246081"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="109" mass="11956" checksum="E6D5491A7044DD8C" modified="2021-02-10" version="1">MGWFSDDSDQAQAYNDYNNNGVDQNQPHLSHELIAGAASYEAAKAYENHCAENGQPGSHAEAKEIMSGFAGAFIDREVESKGMDFIDAEKAKYQAQQHIDNVPADQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3E1</accession>
    <name>A0A7D5V3E1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trs23</name>
        <name evidence="8" type="ORF">G6M90_00g097690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987638.1">
        <property type="nucleotide sequence ID" value="XM_066131532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3E1"/>
    <dbReference type="GeneID" id="90968166"/>
    <dbReference type="KEGG" id="mbrn:90968166"/>
    <dbReference type="OrthoDB" id="4938623at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20801" checksum="D39F65E928C25532" modified="2021-02-10" version="1">MSEAQYSIPYAVTSTIHRRLLNNTEPPDTMTVFALIIINKAGGLVYNKTFHDSGLHKISTNDYLVLAGTFHGVHAITARLNPIRPITPHPGTNGVAIRPEPSSGLEVLETENFRLQCFNTMTGTKFLLFTDSTQANVDVTIRRIYDLYSDYVMKNPFYSLEMPIRCDIFDRKLLSYIREINNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3P5</accession>
    <name>A0A7D5V3P5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CDA</name>
        <name evidence="15" type="ORF">G6M90_00g102460</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546100.2">
        <property type="nucleotide sequence ID" value="XM_014690614.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3P5"/>
    <dbReference type="GeneID" id="26240523"/>
    <dbReference type="KEGG" id="mbrn:26240523"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="70"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI72759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="163" mass="16965" checksum="3CAD60390B2F4FEA" modified="2021-02-10" version="1">MSRAPPTIHASSSAASIAATCEAHALTPEQFAALRSQASAAKAAAYCPYSKFRVGAAVLGDDGSVTTGANVENASYPVGTCAERVALGKAVTDRGLRAFKAVAVATDVAPPASPCGMCRQLGSIREFCRLDMPVIMFDKDENYVVLTLEELLPLSFGPEKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMS7</accession>
    <name>A0A7D5YMS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g020220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548523.1">
        <property type="nucleotide sequence ID" value="XM_014693037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMS7"/>
    <dbReference type="GeneID" id="26237967"/>
    <dbReference type="KEGG" id="mbrn:26237967"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="130" mass="14241" checksum="311BB173F9BCACF3" modified="2021-02-10" version="1">MSLRVFLVESLGFPRSHHAIFVEASRGGGGYIFHVTGNIQQGMRYEMKATDAAPDTDPSYHGQTRLGWSSANDMARIDAICKSNPAPEKQFEGARKITAYPVRRCQEWTAETIGLLRERGVLVDGGDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN97</accession>
    <name>A0A7D5YN97_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NUT2</name>
        <name evidence="9" type="synonym">MED10</name>
        <name evidence="11" type="ORF">G6M90_00g018580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548682.1">
        <property type="nucleotide sequence ID" value="XM_014693196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN97"/>
    <dbReference type="GeneID" id="26238126"/>
    <dbReference type="KEGG" id="mbrn:26238126"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="169" mass="18423" checksum="0A098DDFF139BE82" modified="2021-02-10" version="1">MAPVDRLDQDVLEQQLKDVIQDLYQIMVQVSTYDTTGRPSRDVLSNEMKTLSASLQALHATTSSNASLPSVPPELLEYVENGRNPDIYTREFVELVRRGNQLMRGKMHAFGEFRDVLAREMATALPELRPDVERVVRETGGRPLPEVNGAGAAAAAASSSTGAPGNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQ69</accession>
    <name>A0A7D5YQ69_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g004840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542131.1">
        <property type="nucleotide sequence ID" value="XM_014686645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQ69"/>
    <dbReference type="GeneID" id="26245162"/>
    <dbReference type="KEGG" id="mbrn:26245162"/>
    <dbReference type="OrthoDB" id="4960687at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="91" mass="9730" checksum="7A3014B5FA2AFCCF" modified="2021-02-10" version="1">MPKMDSSTTPQPTKGGVPTQNSQHTTKDTEDSRVPLSAEPGVYKDDGVRQVPLSAEPGVYKHDDRNSPKEGTAGDKGVRIENEGKGITPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQM2</accession>
    <name>A0A7D5YQM2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rrb1</name>
        <name evidence="9" type="ORF">G6M90_00g041050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547451.1">
        <property type="nucleotide sequence ID" value="XM_014691965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQM2"/>
    <dbReference type="GeneID" id="26240014"/>
    <dbReference type="KEGG" id="mbrn:26240014"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="298"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="486" mass="53678" checksum="2C285B29AD5332A7" modified="2021-02-10" version="1">MSKRVANENGDGPLKGGDRPEAMDVDDREMGDFEDEFEDEFESEDEIFEAGVDGRPDAEREAEEKAAAMDVDQGTFIVGRNKLEPGQTLAPDLSTYEMLHNLSTPWPCLSFDIVRDALGDNRKAYPATMYMVAGTQAETGKASDNQLMVNKFSGLSRMEKQDEEDSDDDDDDEDSDPILESKAIPLNSTTNRIRAHQIPSNEPGRPPTTLTATMTESGNVFIHDVTPHLASFDNPGTTITAQQNKPISTIRAHKSEGYAVDWSPMVPSGKLLTGDNDGLIYVTTRTDGGGWVTDNRPFQGHTSSVEEIQWSPSEQSVFASASSDGSIRIWDVRSKSRKPALTVQVSKYDVNVMSWSRQTSHLLASGADDGTWGVWDLRQWKTSTDKPQPLASFDFHKEQITSLEWHPTDDSIMAVAAGDSTVTLWDLAVELDDEESKDTAGVKDVPPQLLFVHYLKDAKEVHWHPQITGSLVATGEEFSVFRTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRN9</accession>
    <name>A0A7D5YRN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ochratoxin highly reducing polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OTApks</name>
        <name evidence="13" type="ORF">G6M90_00g052420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986759.1">
        <property type="nucleotide sequence ID" value="XM_066130541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26246733"/>
    <dbReference type="KEGG" id="mbrn:26246733"/>
    <dbReference type="OrthoDB" id="5122774at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
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        <property type="entry name" value="ADH-like_N"/>
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    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
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    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
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    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
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    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="11"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="966"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2482"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="966"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2567" mass="279774" checksum="540E9B1B08FC108B" modified="2021-02-10" version="1">MGSASRNEDMYEPIAIIGLACRYGGDVKNSSELLRHVMKARSVYGAVPEGRLDARHLYHPATGHIGSIYSNGGYFLKDDINNFDSAFFQLPENDVVAMDPQQKMLLEGVYHALENAGMSMKEIASTTTSVYVGCSNNDSLAIANSDLLSTLQCTSTGTSPSILSNRISWFYDLRGTSQTIDTACSSSLVAFHQACQSIQHGHSMAIACGVNIMEHPGATQNLCSLGVLSPDGQCFTFDERANGYGRGEGVGTVILKPLRAALRDGNHVRAVVRSTGSNQDGRTAGITLPNAVAQEQLIRSVYAAANLNMADTGYVEAHGTGTFVGDPLELTAISSAFAPNRESDLFVSSVKSVIGHLEGGAGIAGLISATLAVESGSIPPVTNLQKLNPNIPNQKRIRFTKEAIPWPRSDLRRASVNSFGFGGTNAHVVLEDIGGFLSQNEGFAAESLNTMKPFTNGHAHTNGLNHQDSDIESSVNGLTHKPNGAVISSPAKKRILTLSGFDEDGIQRNNARLVEYLQSVPVKGQFLENFLHTVNEKRSSFDWRCYYILDSHDSLLSSLRQVPHPIRVSKTPKIVRFVFTGQGANWPGMAQDLLVYRIFETRICEAAKYFMDLGADWDLREILARSDLDMTEPTLAQSTCIAVQVGLVDLLMSWNIVPTTVVGHSSGEIAAAYCAGKISRQAAWKVAFCRGVVCSKSMGNGTMMAAAVGEKQAEELLSRLGGIEQPLQVQIGCFNSPKNLTFTGKRESLDTLKQELEQSGIFCKLLGVKVAYHSAELKAVAGEYLTSLGDLNFGDRVNQNTGIRMHSSLTGECIGPHEDIGPEYWVKNLVSPVRFTSALLHSIGADSDLKRLDKVTDTIIEIGPHSALRSAIQDTFADSQILQSIGYASILKRGETSGETVLQTMGLLYTLGYPVDITAVNEREMANGFSTKHVLNDLPPYAFRHTSKRATTRQIEALKFPAFGRHELLGVPLLDSNPFEQRWRNFIGPQQVPWLSSNRLNDKILFPGVAYILMAVEAALLRFGALDAGAVELRNISILESLFVPDDAVGVEIIFSLSQLHEATELSGGWSRFRFVSHNLDGDSWTEHCVGSIRVEKGTASPPRPLFSEAMRAATASTEAENRYFTEMIEPDKLYQSFSSAGTNFGDYLKGISEFRRSQDRMAYMSHVLSPDIPRTAHDRYTIHPCALESILQGLLCLGSPEDTTVNGSMVANRLGHVWITNPLSDETATSRQFKTFAETERKTSTIYTSDVAIYAQGSLEPNFLIKGLDLVLLPPQEDGQAADESFYVETWKPDAKMLTSFEKVCSSQELSGSLIRAFTREDHQGLQLTCSVFVLDSLQKISGLNEDDLPLHLRSFVDWIKAQAEIITQGRAPFVDLTALEQVRVKDELKQALFDSVARRSARGELLIRVGVNLVPILTQQVDSLELMFGSDDIMSRTYNEGLPGDVAILEVGAGTGSATKIVLDAFRNSGGQDAESGILPIDTYDFTDMSGAFFERAKSRFADWSDVLRYQTFDVEKDPALQGFELASYDLVIATHVLHATANLQVSLKNIKSLLKSGGDLIVIENVKPQLMCTPLAFGILPGWWRGIESYRQSNPLIDQKQWDAELEQAGFKLRMQIQDTDEAANQETSATIASTQQLLDETCQHGYKCAIIYHADYVSQLQLARECASTLTKVLECDCSLVSLREADAGELDADFCVSLLNLQGFDLSDITDPDFQQIKLVLETCINMIWVSGNPDDDSKAAMCRGLVRSARWERDQDAVNFITLGICNPLPPNSVISEQVARVARGAFISQGVIAANGEYATKDGVLLTNRLLPAKKINTAVNRRSDPKTEPIQLGAISQGIKLTSIDPHKPQAFHFIRDELAESPLGHDEVQLKVHAAGVRREDIDEASRLIPGQGIGRDCVGLVTEIGSSVTDVVVGDRVMAVRTIPSSGALSSLFRTHCSAVQKIPDGVGYLEAATIPWNFCTAHYCIVKVARVQPGETIMIQCADNAIGQAAIQLAKSIGANLLCTVSSNEDNLVLASRYNLDQAAVLSNDKVPLGVEAILSSMCKGGINVYLNCDPMGISDAYQSQVTPFGRVVDLHGAATANHLSLKDLSKASISYISVAMDPVAQSRPELIQEALLDTSRRLSCSQFKPLSHVEVLGYSELPKAILRCRDRQSKNPSMFVVQPKDDEVVPMRLEPIGDYLLRGDASYLLVGGFGGIGRRLALWMHSRGARNFIFLSRSGPTDPRARELCETLKSSGCRVESIVSDAADTESVNKSMQRCRDIMPPIKGCVQCSMVLVDSMICNMSHSQFMAAIRPKVQGTINITNNLPEKLDFFILLSSSSAIIGNRGQANYAAANVFLDTFARHLTAQGRPTTSISLGSVLSFGWVAENQDRLPIALAYGTITEDRLLSILEYHMDPRLGAAENSDNCHTIAGLRSASDFQRHSVPLPAFMSHPLFTHLRASGRQGRAKEAEATISIAQGLAGAASTEEAVDFVSDAIIAKISRIMAISPKDMETYRTLSSYGVDSLVTVDMKSWFKRELGATVGTKDILGELTIYGLAGKVVTGSSLRKESVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRW3</accession>
    <name>A0A7D5YRW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 2</fullName>
            <shortName evidence="6">tRNA-yW-synthesizing protein 2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trm12</name>
        <name evidence="8" type="ORF">G6M90_00g034000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543327.1">
        <property type="nucleotide sequence ID" value="XM_014687841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRW3"/>
    <dbReference type="GeneID" id="26244128"/>
    <dbReference type="KEGG" id="mbrn:26244128"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026274">
        <property type="entry name" value="tRNA_wybutosine_synth_prot_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038972">
        <property type="entry name" value="Trm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="7">
        <location>
            <begin position="87"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="44964" checksum="0FC0D9CC610FC2FD" modified="2021-02-10" version="1">MPRPQPHTDPIQTAIAAWLTSLNPPVNEDSTAWKMSLGEHAPKRFTIYEPMALLPAGSFTSASWTTELQRHNGATTDFLWELILEELSKTGKSDLRLTHLAVNEGIPLQSQERKEENIIRSPSGLRILYGDFGPGAPSSISPSNEDFEKAFWVSTKQNGIYQTWAPRWTMFSRGNVKEKARLLQFPAVPRKKKDGNKSQDTWAVDLYAGIGYFAFCYAKLGFRVLCWELNPWSVEALRRGAHLNKWTVEVIEGEKLKQSTEEIMNSTASIVVFSESNENARWRAENMKQEGEWLHDVRHVNCGLLPTSRLTWDVSLFLTRNAIIRGGEAWLHLHENVGDAEIDSRKDEIQTLLRENQDEKSLTRAITVERVEKVKTYAPGVWHCVFDVRIVTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRZ5</accession>
    <name>A0A7D5YRZ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase MIY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YP191</name>
        <name evidence="3" type="ORF">G6M90_00g032730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543204.1">
        <property type="nucleotide sequence ID" value="XM_014687718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRZ5"/>
    <dbReference type="GeneID" id="26244005"/>
    <dbReference type="KEGG" id="mbrn:26244005"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="330"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="908" mass="99409" checksum="002312809B01B54A" modified="2021-02-10" version="1">MVSQELPKHDTAAPSADSAQPLHPQQQYPQQPSQTPWPDDPSEAIWEHVGVERGSSGTPACPPPSHPVANTPPPGNSLTSQGDADENVWDEAKRQQPSQAETNSPGQIPDILRPGGNRAATNPFLKRKPVPQTPEAMPTEAFSKLSVDDASQDANPWQQVVDSQRTHMGHPTPQPRPVTADGIESDPWAANIDEPSISQPSIPPKSPALISLKSDNDDQPAWKDELVNNGDQTVIESPPTAVADELLHQNVWDDLGAFDKGKAKVQQLSAPGHAAQIDDWSLIDAESCSTPSKHAKEDESADERPPLPARSTGLQQKWVPSRPPVDAKAETYQVKNIRWHDAKSQQNPRTSPILIQNENGPCPLVALVNALTLTTPADNPDTTFVQVLRSREQISLNLLLDAVLDELMSPRRTNSEDALPDVSDLYAFLQSLHTGMNVNPRFVPTPAMVDAYKRTSLTHLHPTERGNLIPGTFENTMEMSLYAAFSIPLIHGWLPSQTDPAYSALERQAGSYEDVQNLLFREEELEEKLASPTGLTEDEQQLYQDIVTIKMFLSASATQLTAWGIEVIGKAMRPGTFAILFRNDHFSTLYCHPQTLQLLSLVTDAGYRTHDEVVWESLVDVNGERTEYLSGDYRLIGLTHEAGPSTNLNSSTTDHGGQWTTVQNKRGKGRQQDEETGSAVSPHEQEDRDLALALQLQEEEDQKHREEQARRQRERALSEQYIEQQGHRPAPVNRDRRRTSTPGHGGIAPERRSSNTYSVPVTTSTSHPQQSGISQPLQPQQQQAPVQQQVVRPLVPPRRPGVTRRAESNGDDAPPSYEQAAQAAAYIPPVGHPSHSQSSTALSRQTSASVEPSAAASQVQGVAGQPLISVDPPTNFVPGSHSQRASMSSSSRRQAVGHGGRDKDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT69</accession>
    <name>A0A7D5YT69_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC1 domain family member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TBC1D5</name>
        <name evidence="4" type="ORF">G6M90_00g013830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549139.1">
        <property type="nucleotide sequence ID" value="XM_014693653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT69"/>
    <dbReference type="GeneID" id="26238583"/>
    <dbReference type="KEGG" id="mbrn:26238583"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="49"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="741" mass="82603" checksum="D0701BF8BA63BD6A" modified="2021-02-10" version="1">MARPALVCRAVGPYAGRYLTVFEPSSPHTITLATCIADELIHAFDQTFLLSTKGRITSWADALEEGRKDYQERRDHFLKFIRHPEALTELTVDPLADDPDSPWNTVRQDEIIRTEIQQDVQRLPDEVNYHEDAVQGMILDILFIYCKVNPDRGGYRQGMHELLAPVVYALEQDSIDSEASGNDARLDAKMLHVLDSAFIEHDAYILFSKLMEQAQSFYEVVNGSTPSNHDSQPVIMQEQLSAIVERSRFIHEICLQKVDPELAVHLTNIEILPQIFLIRWIRLLFSREFPFSQLLVLWDTIFAVDPSLELIDLICVAMLVRIRWQLLAADYSVCLQLLLKYPPPEQPHGPHTFVDDAVYLRDHLDFTGGSSLIMKYTGRIPENPNDIKPTQPSRGAESEANSVRQLGGRPPISPSRLTQQPPSMEAFFQGAARGANRVLERGEKLGINQAVRDAMGEIRRNVQSFNEARQAQRSPRSILSDEGASKVLAAMERRNKELAGLLNDTVTNLKTISLSGFEDEAKSLELIEVAAAKIQFVQIYLEDSTMDVPVFSTPKNKLVSSPEGKEKVVEEATETRATTANQLHVAPATSSDAPAPDVSKLEINEEKHSSKKDAADPEKMVASQDDQPGEAPPSDPLGNNTVKVRPAPVPTRSTLAQSSFSWMLEPDETTPSRAPAASKSPPSQHGKRHSNNLSRERNAFLFGEMTAEATDRSAPPKTDDIFGMEPIAKPKGKTQGLFHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTC5</accession>
    <name>A0A7D5YTC5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ketoisovalerate reductase BEA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BEA2</name>
        <name evidence="6" type="ORF">G6M90_00g056900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544276.1">
        <property type="nucleotide sequence ID" value="XM_014688790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTC5"/>
    <dbReference type="GeneID" id="26242688"/>
    <dbReference type="KEGG" id="mbrn:26242688"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="262"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="437" mass="48138" checksum="6E2ADE56D5EE3281" modified="2021-02-10" version="1">MPSSQQPAWLKTLIADQGPPPNLFAWTPENLDLGAKHNTPAISPTGGRNDLDRRVFILGVGNIGRLYASCLARQPRPPPITLVVHRKELLTQWVQGDGVELTRDSVAIKNKDFDIEWWTRTAPDHGPVREVADGKKLRNLFISTKASAAMPEADRLRGYLDRHSTVVFAQNGMSKLWPPHGQEYIAHRYEAGNAPSFLACIVNHGVLSVGPFKSVHTALADASIGPVLVNPHPPPSVEFFMTQVATAPLLNSKSVSAGELWLLQLEKLVMNAIINPLTALLRCKNGELFAGGELNNPLGQVLDKLLAETSAVIHALVNHESSADILASYMDQNQPSKSDIPTENIHELQKGLAERFSLPYLKKKLYRFGVQVGENRSSMLQDVEAGKPTEIRDFNGWLVDMAAFLDQRLDVSTHRALIELVEGNVILNQAELANRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU32</accession>
    <name>A0A7D5YU32_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bypass of stop codon protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BSC6_2</name>
        <name evidence="10" type="ORF">G6M90_00g054880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540918.1">
        <property type="nucleotide sequence ID" value="XM_014685432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU32"/>
    <dbReference type="GeneID" id="26246224"/>
    <dbReference type="KEGG" id="mbrn:26246224"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="85"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="470" mass="50057" checksum="2A192863E7D917C3" modified="2021-02-10" version="1">MSQTIASTQQICSPPYDAIELTRFSSRTSCGRGIDAQLKDTDTIRATAEAKLGTTSGTTSDDSEPPADAQGQVERWNYPRSNVFKLGFACLSFVIAGMNDGAVGALIPYLEDYYNLNYTVVSLIFLTPFVGYSLAAFTNARIHVALGRRGVSIMAPLCHIVTYAVLTSHPPYPALVVANSISGFGNGLTDACFCAWLGAMDKANAIQGVLHSCYSLGALFAPLIATSMVVKAGLPWYNYYYVMIGTAALELGGLAAAFWDQPGSVYRAEHASDNEGSGAGTREAAKSKVTWLCATFFFLYMGVEVGLGGWVVTFMLKVRHATPYASGISGSGFWAGMTLGRAALGFATERYGERTCLTVYLAICIALELLFWLVPQFVVSAVAIAFLGFFLGPMFPGAVMVTAKLLPKRIHVSAIGFAMALGGTGGTVFPFMIGAVASTAGVQVLQPIVLALIVVVTVVWLSFPKIRKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU63</accession>
    <name>A0A7D5YU63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mite allergen Eur m 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EURM3</name>
        <name evidence="6" type="ORF">G6M90_00g063630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI69141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542522.1">
        <property type="nucleotide sequence ID" value="XM_014687036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU63"/>
    <dbReference type="GeneID" id="26244471"/>
    <dbReference type="KEGG" id="mbrn:26244471"/>
    <dbReference type="OrthoDB" id="4915747at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028836420" evidence="4">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="411" mass="43901" checksum="D3DB80254B163F20" modified="2021-02-10" version="1">MLPKTTIALAVAFPAISAAAPTINKRIIGGTDAEIGDFTSMVSIQMGNDLCGGTLLSKYTVLIAAHCLGAANNDTVAKAGVADNKKDGEYSSIREIKVHPDFNTYGHYTLDDIALVYLKEGFDEGETIAYANLAVNGSDPEVGSEHIALGWGTQNYEKFKDRPDPTDKLSKVGLEIYPRGHCWSRLLGAGKTGAETIVCAGGRGKNVCKHDDGGPLIDQKKRVVGIASLVIKDRGGSYCNLEPSVFTRVGSYSDWINENLVTEPPTSTEEQTDFSFEFPKLINGDVEAKPPASTEDDVYVEFPSPTKPVPTSVPTVSNFPPNLNIVVTDVCDRRGLGSDNSCPPVVKYCIFKFKEDGYSSTNACVGAFEKAGLMTATKNKEAGLTPGTENQGTENQGTANKGTENQMCSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVH2</accession>
    <name>A0A7D5YVH2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">zipt-7.1</name>
        <name evidence="8" type="ORF">G6M90_00g006810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549828.1">
        <property type="nucleotide sequence ID" value="XM_014694342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVH2"/>
    <dbReference type="GeneID" id="26239272"/>
    <dbReference type="KEGG" id="mbrn:26239272"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028953834" evidence="7">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="412" mass="43483" checksum="BFABE3C985929783" modified="2021-02-10" version="1">MARPAVLWLLLALTACALAAPQNEVSKHALESLSLDDLDHELQTCPIVQELSAIKHAHHAAAPSSLTTRLFAVLFPGSPAVNALLATLYISGPPNFLLALCPTNIDPSSLSVMVAFAVGGLLGDTLFHLLPEIFLGEDEPDRARFVLVEPNRNLVLGLAILVGFMTFVAMDKGLRIATGGAGHDHHSHAHAHEADAQTTTAAASGADTGTGNGQVKSRRKGKGKKEHADEDHHKEVNPSVKLGGYLNLIADFTHNITDGLAMSASFYASPTIGATTTVAVFFHEIPHEVGDFALLVQSGFSKRAAMASQFVTAIGALMGTLIGIAIQEFGGGNTDGEASMPRNAGLWGTSLTWGDMLLPFTAGTFLYVGTVAVIPELLETGPNKMQELRKTLVQFSAVAVGAGIMLYISWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVT7</accession>
    <name>A0A7D5YVT7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g015960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985989.1">
        <property type="nucleotide sequence ID" value="XM_066129780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVT7"/>
    <dbReference type="GeneID" id="26238376"/>
    <dbReference type="KEGG" id="mbrn:26238376"/>
    <dbReference type="OrthoDB" id="4937202at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028813174" description="PA14 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="147"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="37412" checksum="99AB7F8EDCAFBA19" modified="2021-02-10" version="1">MHRRLLSTGYLVVSAFQVILAQDSNLESLLPRHKSPLLGDIRKSLRTACDVTEFPASIEKLCDEYCESEIAASDLKGRLCKNFRKYIESLGKCAKDTRSTVNKQCKDKCRCSKDDDCDINDVCKDHACNPKDMICSNDHCMPKPPTCGQPGFDWAEWRGPLSWNSVKSPPFTEYDPTVFKSQRPEHGGRTNTLLIDNPEDLYGQAIDINLASVIHQGFLLAPETGNYTFLFGQADDIVLVWLGENAFRGWTRANADIERTYIPPPGDETRTTRHLEQGTYYPIRVAWGDKGGNTAMSVRIMAPNGTELTGQNGGYFRTEACDGSYDKFPPYGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW23</accession>
    <name>A0A7D5YW23_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g021970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548355.1">
        <property type="nucleotide sequence ID" value="XM_014692869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW23"/>
    <dbReference type="GeneID" id="26237799"/>
    <dbReference type="KEGG" id="mbrn:26237799"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="27795" checksum="98E8DA2B04C2DEE3" modified="2021-02-10" version="1">MKPDPETSAAPSSFPTKTPATTPKKPPCAQSKDFTLPKLRLEIRDLTHPGANLALTSVNAAETITTAARNVLRLLYTSPASPTTTPPPTRSITLILRDMPGVAYTTGTELDDDHKEVHFSLNHIAGTSKPRAAQEITGVITHELVHCLQWNAFGTCPGGLVEGVADWVRLNCDLAPPHWKKEAADKWDAGYQHTAYFLDYLERTRGAGLVTRLNEKLRIERYAERRFWMELTGQTVDDLFAEYVESLKAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWB4</accession>
    <name>A0A7D5YWB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">duo1</name>
        <name evidence="20" type="ORF">G6M90_00g037380</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986427.1">
        <property type="nucleotide sequence ID" value="XM_066130222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWB4"/>
    <dbReference type="GeneID" id="26239662"/>
    <dbReference type="KEGG" id="mbrn:26239662"/>
    <dbReference type="OrthoDB" id="4941189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI67684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="196" mass="21917" checksum="0D91E8A01282B7A3" modified="2021-02-10" version="1">MADDTEYTESDIWASPSHDAPLAARPKTPKTPKTPKTPTGPPASETVSRDDLLRRELEGVRSVNEGIEGLLGTLNRAGGNMQVVAKTVANASTLLNTWTRILSQTEHNQRLILHPGWKGVTQDLAEQEAEALEKQRAAERKAAEEEQRREELRRRREEEETARRLAPSTSREVARREAVCPNHLHQAHQEVAELQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWK8</accession>
    <name>A0A7D5YWK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g004810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985721.1">
        <property type="nucleotide sequence ID" value="XM_066129578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWK8"/>
    <dbReference type="GeneID" id="26245159"/>
    <dbReference type="KEGG" id="mbrn:26245159"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
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        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
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        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="56524" checksum="BEB60A3826B3F235" modified="2021-02-10" version="1">MDSRQTAGQENHRAPNHVPAGLPKSDEDDTYLPHVLSESSPLLIKVDDVVQYQAVVWETTEELRAEAVVEATPSGGVCVTWKTEAKYIASSSVSLLVTFVLQYSINVASVFSAGRIGKVELGAVALANMTTGVTCLAPFMGLATSLDTLCAQAYGDGRNHLVGIQCQRMVMFLSCLSLPVAALWACSEGILLRVIDDGESARLASLYLKVMISALPGIVLFEAAKRLLQAQGLFRQTTYVILVLAPINIFLNWLLVWKLELGFVGAPIAVALSRNLLALLLILYIKLVNGYQCWGGLSLKAFSNWRPMVFLALPGMVMVAAEWLIFDIITFLSSRFGTDYLAAQSILVSVTTLIYHVPFAISVAASTRVANLIGAGLVDAAKAAAKVAAVAALVMSVLNFLIYMMLRYQIPLLLTRDASVIMLTAQAMPLVALEQFFDSLCTGAHGLLRGIGKQSIGGPVNLIGHYLVSLPLCLILGFQYSWKLAGLWGGIAAGLMVVSLVEYGYLLTIDWQVACEEAEARNTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXG0</accession>
    <name>A0A7D5YXG0_9HYPO</name>
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        <recommendedName>
            <fullName evidence="8">Magnesium transporter NIPA4</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">G6M90_00g027940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685880.2"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
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            <end position="97"/>
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    </feature>
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            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
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            <begin position="273"/>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36405" checksum="380AF97D4924399D" modified="2021-02-10" version="1">MNKDVYICLILATFSAAAIGTSFVITRKGLMDARKNQGFNGDGFEYLRNPLWWLGICSLVLGEICNFAAYAFAPAILVTPLGALSVIFGAVMGSFLLNEQLGPVGRSGIAICLLGAVLVIIHAPPEQPVETIDQILDYALQPGFLLYALAVLGTVVFLIYKVAPVYGKKHALVYLSVCSLVGSISIMGIKALGMALKLTFSGNNQFTHPSTYAFLLLSAGCIVVQMNYFNKALASFPANIVNPLYYVTFTTATLSASLILYGGLSIKNVVTNLSLLLGLLVTFVGVIILNLSQRDAGIRNSVTRGSFERIPFQSLSNASSASLANNYYYSRYDDESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXK7</accession>
    <name>A0A7D5YXK7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonate--CoA ligase ACSF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Acsf3</name>
        <name evidence="3" type="ORF">G6M90_00g025590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548024.1">
        <property type="nucleotide sequence ID" value="XM_014692538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXK7"/>
    <dbReference type="GeneID" id="26237468"/>
    <dbReference type="KEGG" id="mbrn:26237468"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="478"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="575" mass="62515" checksum="8D05F5A31C9FBD7D" modified="2021-02-10" version="1">MHSTTLPRLPIFEAIVKHDPQSTAVIHSSSGRTFTYGELLGDIRKARERFYEASGKKDLNGERIAFLVGNSYDYVVTLLAVLAARSIAVPMSPAFPAPELQYILDHSEAALLVSSPRFASKAAEVLATDLTTKPAHLELKKHEGGGMCEVVSLEEGSDPAGAGLMLYTSGTTNRPKGVLLPQSALTAQSRSLIEAWKYTPADHLLHVLPLHHIHGTVNAVITPLFAGSSVEFMFPFNADAVWKRLAAPFLPTNGTNRPHGTTKPPNSKVTFLTVVPTVYSRLLASHKLLPHPIQAAAREAISPANMRVNISGSAALPTPIKTAWSDLSHGNVLLERYGMTEVGMALSCGLSFTDRIDASVGWPLPSVQARLMDVDTGEIIPLGGEVDSQGRERSGEIQLRGPTVFKEYWRNPSATAKEFIPDSDGRGSWFKTGDVAIRRAVPAASHSQPWTKGPLYFIQGRLTADIIKTGGEKVSALEVERELLSLPEVSEAAVVAVPSGNWGQKVGAVLIINRDVVQKWSPLDMRRALKSRLANYKIPQVMKIVEHIPRNAMGKINKKQLVKEIFADEHSGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYA3</accession>
    <name>A0A7D5YYA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g024660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548116.1">
        <property type="nucleotide sequence ID" value="XM_014692630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYA3"/>
    <dbReference type="GeneID" id="26237560"/>
    <dbReference type="KEGG" id="mbrn:26237560"/>
    <dbReference type="OrthoDB" id="3877279at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34067" checksum="40ED9DEA1660542E" modified="2021-02-10" version="1">MRRDNDEVAAAMADDNGTYFTYRPLSNLPTPPPTYKESKSPSTIASSSLEDGEPLKAKYRGPAIHLVNLIPSSASFAIASVPIVQAILSRADLPIETVALAVCILDSLDKKFARAWRLSCPLLPGTWATSSTNKRHTLPPTPLLYQHQQHQMLHIDSVPPELIILAALVIAVKFIEDPQQPTQYYCDAWGRGTWSHDQLNATERCIMESLNYRIMPLCDEDCLSDAMVDMQLAGRQLDWDTPPLSPPDSLASSGSNMDRNFVLGHCRSKTMMPSTAALGLGLSLTPSESPCTTSCEAVTTPRSETLGTTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZN4</accession>
    <name>A0A7D5YZN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">iki3</name>
        <name evidence="13" type="ORF">G6M90_00g008610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549648.1">
        <property type="nucleotide sequence ID" value="XM_014694162.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239092"/>
    <dbReference type="KEGG" id="mbrn:26239092"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="9">
        <location>
            <begin position="392"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="11">
        <location>
            <begin position="674"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="10">
        <location>
            <begin position="884"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1150"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1294" mass="143404" checksum="3C9CF85D2BD45D6F" modified="2021-02-10" version="1">MRNLRNVRFGRWSHPDITSACWDPEKDEVVCTIGPTADSTSIELVRVSENGLTSYKSVASWNAPSPSPDLAVDKVVNIQYLSSSGTTCLVLEGGDIITVQEDQFSDHGAHIEIMGSIDAGISAARWSPDEELLIVTTKANTAIFMGSSFDPVAEVTMTADDLKASKHVSVGWGKKETQFQGRGAKALRDPTIPEKVDEGLPSAHEDGSTTISWRGDGAYVAVNSVQEGIRRVVRVYSREGELDSASEPVDGLEGALSWRPSGNLMAGIQRLADRIDVVFFERNGLRHGQFTLRSPEGSVMFHEKIRLEWNSDSTVLAVVLNDSIQLWTMGNYHWYLKREITISAEYLCLSWHPEKALRFASASSSETAIFEEAFHTARGSCLPPYDNGAVAVVDGETVKLTPFRTANVPPPMSLFDITAESSVVDVAFGPQNMSFAVLHRKGIEIYDWPMKNGRSIKPNLKSKLSFESTGVTDRVVPLRICSTSGSQFRCLVSSGDSNLVHFAASGDSGTIDILNSQEILVSTSTYEDATSIESYGQDISGNLYKLSETSTDLLPLQFPTHLPWFEIVKFDGELTAFGLSRNGHIYANSRLLAKNCTSFVLTASHLIFTTSNHFVKYVHLVSIVEELEVPEDDPEKDERCRSVERGSRLVVAIPTNMSIVLQMPRGNVETIFPRAMVVAGIRSLIEEKNYSRAFAYCRTQRVDMNILYDHKPTQFLSNVSLFLDELNSMTHIDLFLSSLREEDVTETMYKDTRKSRTQLGIETEPVPTRPSSKVNIVCDAILKALQARKATNIQNIITAHVCKSPPALDDGLMLVAELMREDEKVAEKAMEHICFLVDVNRVYENALGLYNLDLALLVAQQSQRDPREYLPFIQNLHALPELRRKFEIDDHLARRSKALSHLQALDNFDEFCVYTTKHSLYQDALRIYRYEPTRLQSITNLYAAYLESKSSYREAGLAYESLKNYAKATSCYRASGATCWQECLYTAQQQSPPLSAEAMTDLATSLADALWEAKDYTSAATIHLEHLSSLETAIKCLCKGYHFAEAMRLVVQKSCPGLLESAVDVGLAEALGSTTEFLADCKGQLLAQVPRIAELRRKAIEDPLSFYEGERPGGMDIPDDVSVAASSRISTSASLFTRYTGKAGSVGTVGTGVSRATSKNRRREEKKRARGRKGTVYEEEYLVNSVRRLIERVSGTKPEVERLVFALVRRNMAERARAAESLMNDVVEACHTAISEVFAAPPDNDDQQQPVEGVGELTWTAKGGDAVLQEWMEGRAKKQEAPVITALQKLTLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0C8</accession>
    <name>A0A7D5Z0C8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547856.1">
        <property type="nucleotide sequence ID" value="XM_014692370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0C8"/>
    <dbReference type="GeneID" id="26237300"/>
    <dbReference type="KEGG" id="mbrn:26237300"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7721" checksum="1FEEA1147880177D" modified="2021-02-10" version="1">MSRSSYNGTICIRPDRGLRRDNTQQPDNHTIVKQAFANSMPQIMAIIWEEMEKLQRDTDNGQSSGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0V3</accession>
    <name>A0A7D5Z0V3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Sccpdh</name>
        <name evidence="4" type="ORF">G6M90_00g014370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549085.1">
        <property type="nucleotide sequence ID" value="XM_014693599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0V3"/>
    <dbReference type="GeneID" id="26238529"/>
    <dbReference type="KEGG" id="mbrn:26238529"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000592">
        <property type="entry name" value="Similar to saccharopine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="423" mass="46691" checksum="D2A8A707C56A0913" modified="2021-02-10" version="1">MAFKNHGRQYDLVVFGATGYTGQLTAEHVAKFLPTNLKWAVAGRSESKLQSVVEECKKLNPDRLPPSIEIANTNDESQLEALIKKTFIFITTVGPYCVYGEPIFRLCAETGTHYLDCTGEAPWVARMIKKYESTAKDSGAIMIPQSGIESAPPDLISWAMAQHVRTELDAPTKDVVVTIHKLNSAPSGGTLATVLVLFEKFSLKEVIESTKPFATSPIPYTSGAKPQKGLLQSILGVTSRPNLGLLTTSIAGTTDQTVVTRTWGLLHEIPSRKKEFYGPRFTWSEYFKARNWLHGIGIHFALAIGSFFLVFVPPVRSLVKRFIYQPGEGVSREDMEKEEVEFRGTATPDIESNPSQKQAFCRAWFHGSLYMLTGLFLAEAALTILEDDLDLGGGVFTPACLGQKYLDRVNDAGFKIEVRTVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z116</accession>
    <name>A0A7D5Z116_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UBA domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ucp3</name>
        <name evidence="5" type="ORF">G6M90_00g076700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987155.1">
        <property type="nucleotide sequence ID" value="XM_066131061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z116"/>
    <dbReference type="GeneID" id="26241466"/>
    <dbReference type="KEGG" id="mbrn:26241466"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF7">
        <property type="entry name" value="ACTIVATING PROTEIN FOR ARF, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="14"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="65752" checksum="481A04B3F995EBC3" modified="2021-02-10" version="1">MASALSKRQQARNEKALQDLVHHVPGNNLCADCHARNPAWASWSLGVFLCMRCAAIHRKLGTHISKVKSLSMDSWSNEQVDNMRKVGNVTSNQIYNPEGRKAPVPIDADEADSAMERFIRQKYIHNVAVKSGTPRSRGSDEGTPPPLPPKNSTKFGFRSASSIFPLTSRAKKEQRVLGGSNGSAVPSPTLPNKPSRLFGATVDYAAPDETDKKLTRLYEMGFQDPQRNAIVLKGVNGNLDQAVEALVRLGEGRNPSPALMPASREPTLRATKSMTPLNSNSGSAGVGLSLSVPQKPMLDRPTSSSTTSTNPFDMMPPAQPQTAQSTGTLHNKNPYNGTNNPFGAPSQQVDLSQALQGLHVSTSASHPTFFPQSNGVHQLQMSQQQQLYQQYMSPSAPASPQSYQPMTFQSSMTYPQPISSLQQPMQTGYNPFFSQPSSPAPPPQNLTVKTAQGGFANNPFLRSPSRIASPPLIQIPEQAQSNFAESPFLSTSPQPLPTPSNPFFTNMHQPQPQVQQFVQQSYAVQQPQQPYYQKPRHDKASIMALFNQPGQYTPKPAATEPIYPATAHGKPATTQYVTANNWEYESIYEPNYDPIGSFRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1B8</accession>
    <name>A0A7D5Z1B8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g055610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544155.1">
        <property type="nucleotide sequence ID" value="XM_014688669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1B8"/>
    <dbReference type="GeneID" id="26242567"/>
    <dbReference type="KEGG" id="mbrn:26242567"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="413" mass="46347" checksum="EC117A96ECA6918D" modified="2021-02-10" version="1">MPNTSPNANWVTSDSLDAGANRIHGQIQAVLATANFEYLQEVALLSRKARDKSIPAGVTCTIDSKIFTYGMNNLVLKVGFSDHVNWIARVQHVPVDLSHARDHAMDMLSEIATMKTLKSRTTIPVPEVFVFDPSLSNEFGFPYILMERLKGRVLDSTIASDVPAECLPQVARQLADVLFQLENLSFDRLGRIWCGENCDEPPTIIPWERVDTASAIPHIETSLEWFYLSRQNANRSALEAHASDPEWTTACWVLKTAISHIIIEDRLRGPFPLCHFDLHYGNLLFDDEYNLTGVLDWSLTATAPLERLAVSPEFITFPALPDQENQPIVAFRDATRNCLQELVNKTEQSSAAIGRKTTLSMILGSKQAEITHRCTYSRPHRAVCDGRLVSRLIYGDKVSWEQLVAVYGGIKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1F7</accession>
    <name>A0A7D5Z1F7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase HERC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HERC2</name>
        <name evidence="10" type="ORF">G6M90_00g028500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541314.1">
        <property type="nucleotide sequence ID" value="XM_014685828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1F7"/>
    <dbReference type="GeneID" id="26245949"/>
    <dbReference type="KEGG" id="mbrn:26245949"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="8">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="763"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="880" mass="99531" checksum="05C0D6C5DB9B5358" modified="2021-02-10" version="1">MWPSTPSADSLTRPRIAVAVVSVVAAASVGYYAYRAHQNESSRETPTGGGLHRSNAIRRPRRTTSIFQYGTPLDENTEGTNFRVPGDAETVVDVDVETSDDWWNEPPATTVPLSPRAGHTIVSLLFRVSEDNARRNGCVHRGCQCNSCGMVPIRGVRYRCANCADFDLCETCESQGVHNKTHIFYKIKVPAPPFGPRQMQPVWYTGDPDTCRRNIPKGLIARLSRDTGFERPELEAFWEQWTYMANTDWRDDPEELCVAMDRKTFERCLVPTGGSRHAAPNLIHDRMFSFYDSNKDGLIGFSEFLHGLSYRKRRDKLKRVFEGYDIDGDGYVNRRDFLRMFRAYYVLYKQMHKDILDGLDDQLLASTEAQQLVSSRQPLSSLFGREGRIPSADSGFRIEGKTNRRDGSIEVADGFSSVFTENRGDTAPREDILASLFAYDTDTRQTRRLVSRSDADTNWRTVRRVSGGDLDRAYWSSLLDPPATLDDIPHVFNNNEDEDVDANVDEDEDEDEDDGDMQTGESGRTYSESRARAIARSRRLAPKLEKQRLDMARKHLHDRWKRRQFYLDEEEGGIAPDDWDAEEDILARVNLITEDSKARDPAPITTRSRSSSKVRFAEDTDDYEIRSNPSTSSRSVPERWGGMDIPDAERDAGKEILYQVTQQAFNELLDTIFKKAEDMAVAAAESAKDREKYKAQIDAIDLPESQSQAPPNQPRPESQPTSKAISEKSLDELLANTGYTVVPDEPRNAVDLDGSVEIIHEEQVDGAGSNTDDERAEYRDPTLPQFRPNNIAEADELAARQGASELEHVPRSSSHQAAQEEPDAATLRSWKRLTIAEAEAVKRGGWGRLSFEEFEDIYKGQEDLGYRLDYLGSWIDFCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1M0</accession>
    <name>A0A7D5Z1M0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g007760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549733.1">
        <property type="nucleotide sequence ID" value="XM_014694247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1M0"/>
    <dbReference type="GeneID" id="26239177"/>
    <dbReference type="KEGG" id="mbrn:26239177"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="293"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="347" mass="35912" checksum="26E5CAE7876F117A" modified="2021-02-10" version="1">MYALAKCSLPRRVVGLLSPANAIHGTTTRSRLLSTLAILEQRDGQLNQGSLNAFAAAKQLGGTVHGFVAGSNVSAAAQEAAKVEGVEQIIKVDSSAYEKGLPETYAPLLVENIKKGKYTHVVAGHTAFGKNLLPRVAALLDCQQISDITAIENDKTFVRPIYAGNAIATVESSDSVKVITIRGTAFAAVTPGSGSAAVVDGVDPKADTSAEWVSEDLAKSDRPDLGTASKVVSGGRGLKSKDDFDRVMLPLADALGAAVGASRAAVDSGYAENSLQVGQTGKVVAPELYMAVGISGAIQHLAGMKDSKVIAAINKDADAPIFQVADVGLVGDLFEKVPELTEKLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1X0</accession>
    <name>A0A7D5Z1X0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine hydroxylase-like protein SAT17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SAT17_1</name>
        <name evidence="4" type="ORF">G6M90_00g048280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544943.1">
        <property type="nucleotide sequence ID" value="XM_014689457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1X0"/>
    <dbReference type="GeneID" id="26242284"/>
    <dbReference type="KEGG" id="mbrn:26242284"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="413" mass="46528" checksum="9A264E1CCA293F19" modified="2021-02-10" version="1">MALGTFTKSVTQPINAGDPTENSTGRSKETRVSTRSLGGNSAVRIPTTLSGQLIWSGQDYHHNNSLYALCLTSEDIAEVEQALEAFKALCLDGDEVSKANFPLPNLTERLEKCSKILHDGLGFFVIKGIDMSHYTVEDSIVIYLGIASYIADQRGIQDREGNVLRHITSSKMWDVPLEKRHGIHSNAALPFHNDMGCDILALQVRHCAHSRGSTFVSSAASIFNQLITVEPAVVRTLFEPNWPVQCSGRHAQHYLAPVMKWHHDRLMTSMDPNRFGPHPASSGSSIPVLTQDQRYALQKLEEAARSTELELDLERGDLLFLNNWALLHRREAYDDDETTCRHLIRLWLRSTRHGWHVPPEMLLPWQTAYNDKIQTRIYALHPSPTYSTPKYSVGSAAFLIYDDEQEVDESLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1X2</accession>
    <name>A0A7D5Z1X2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540430.1">
        <property type="nucleotide sequence ID" value="XM_014684944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1X2"/>
    <dbReference type="GeneID" id="26246792"/>
    <dbReference type="KEGG" id="mbrn:26246792"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="266" mass="29910" checksum="435FF0494D6A98BF" modified="2021-02-10" version="1">MGIEITKLADLCSICEDTVESNGEQVPRTAFAAVDAEENAFFGVKLGIHIKQLTVEVARDCLQPLPDEEIYPYFPTTGLTAAPHDCSGRYVKRTAWPSYLDFKDTTFIPRLMLQEAQTMELLAQWPHPNIVGYYGCRVKRGRIAGLVLETFSFSYDIAFATQRPDLFKGLVDKDRIMSGLRSAVSHLHSMGLAHNDINPANIMLKEQGEPVLIDFGSCQPVGQRLMSCGTAGWRQEEFYTSEIAHDDYSLGILEEWLDNLITRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z271</accession>
    <name>A0A7D5Z271_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scytalone dehydratase-like protein Arp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Arp1_1</name>
        <name evidence="3" type="ORF">G6M90_00g052460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540374.1">
        <property type="nucleotide sequence ID" value="XM_014684888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z271"/>
    <dbReference type="GeneID" id="26246736"/>
    <dbReference type="KEGG" id="mbrn:26246736"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028884298" evidence="1">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="214"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="494" mass="54694" checksum="E96A7E6CC5A9B92C" modified="2021-02-10" version="1">MLILFLAQLAALFVSIVSAKVVSRQIQLGQHEYFMPPSSSWKVPSWDSNFLQNATVDEFVPITVMNLNGTKNDANIRAMLDKFNATDDVWTSSFTQNRIVPSGPYFLHTSTGNAYQAYRLFADTNQAFIQSSYQDPQDTHHPLRAAISSDASLTVAVPSRLYYAPTKDKPLAGVRISVKDLFDLKGLKTSGGNRAFYARRSYFTSHIDYLLPFNPRGDGYNLPSDSSGGSGASVASYDWLDASVGSDTGGSVRGPAQQNGVHGNRPTHSAVDLYGAIPLSPAMDTVGMLARDPLLWSKINRVLYAGSVKEFAKFPKSILLDPSSAKKLSAADQEYPKIAAAANNFLNHLSKILAANVSTFSIDEAWNKSTPVAFNTTPIVNAVDRIYSDLTRYEQWNDFGKAIVSEYMETHNGEFPHMVPDVRVGWLLANASLTEDDYKGDLKDKSGVAEWVAKKFLTRDEDTCSNAIYVYFNMPYKSYKPDISGEYVLRHHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2A1</accession>
    <name>A0A7D5Z2A1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trans-enoyl reductase fsr4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fsr4</name>
        <name evidence="4" type="ORF">G6M90_00g031170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539254.2">
        <property type="nucleotide sequence ID" value="XM_014683768.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2A1"/>
    <dbReference type="GeneID" id="26247954"/>
    <dbReference type="KEGG" id="mbrn:26247954"/>
    <dbReference type="OrthoDB" id="4961446at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="9"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="518" mass="55954" checksum="896F2B68419E2D0A" modified="2021-02-10" version="1">MKQAIVDKAVTVAICDVDIPVAKPGQVVIQVVVSGTNPKDWKMPAWMPDAPAANQGDDIAGYVEAVGGGVLNFKKGDRVAAFHEMMTLGGSYAQYAVAWEHTTFHLPEDTSFEEAATIPLAATTSALGLYQQLSLPLPWNPAPEPLPLVVYGGASAVGAFAIKLARLSNIHPIIAVAGKGTPFVETLIDRSKGDTIIDYRKGDEAVRKAVRDAARGLPIHHAFDAVSEKGSYQNLGAALTAPATITVVLPGQEYNKVPEGVKIVATTVASVHKPADKGKMVSEVEFGAAFFALFGRGLAGGWFTGHPHEVRPDQTPVYAAALLLDPSKRRKYIERNWKESWQASAIAAAQKIWLDEYEAAAVPESLRAPPDISSSSERQHNELDELLSGIAVTGPILDDADDFETFINATPTRITGSPLEWWLHRDQRKAYPRLSRMAIDILSIPPESSDVESHFSSARRTLSWDRESMTCENLAKVECVGNWIREGIIVPKSHGSRGVISSGSVDFSVETEAGDFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2F8</accession>
    <name>A0A7D5Z2F8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">37S ribosomal protein MRP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MRP4</name>
        <name evidence="5" type="ORF">G6M90_00g043420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547677.1">
        <property type="nucleotide sequence ID" value="XM_014692191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2F8"/>
    <dbReference type="GeneID" id="26240240"/>
    <dbReference type="KEGG" id="mbrn:26240240"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="484" mass="53066" checksum="67661F322F89B561" modified="2021-02-10" version="1">MILRNAAIRHGRALAPPISRSALRLLSTEANSQNAVNSSPNASAQAWSAGQSSSAQPKILSGSSSKKRKQKTVQEFIMSLGSDSAQEHSGASWTKPHQIGSEGQEVTPAQQFADFQRIQKNTRSLGSHVERRYVPTELISNPPGPEHVSLELLMASQAHMGHNTSLWNPANSRYIYGVRQGIHIISLETIAAHLRRAARVVEEVSYRGGVILFVGTRKGQMEIVTKAAELAGACHLFTKWTPGAITNRDVILKTQATKVVDHLDSELDGFDMYKGMARPLLPDLVVCLNPLENYTMLYECGLKNIPTIGVIDTNVDPSWVTYTIPANDDSLRAMAVVAGALGRAGQKGKERRLQDSSRGNVSWNTSPELERHMKKEVQAAVTKRKEVMGRIQSNVQGFTEEEQKLLRVRNNEVDLEVSEDEMVNMLGETALKDAGEAVAEAGHVDSSKTSSWKVGEGLADIEAQLQRVQQQTRHIELAVGSKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2V6</accession>
    <name>A0A7D5Z2V6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">csn-2</name>
        <name evidence="11" type="ORF">G6M90_00g001020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542968.1">
        <property type="nucleotide sequence ID" value="XM_014687482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2V6"/>
    <dbReference type="GeneID" id="26244341"/>
    <dbReference type="KEGG" id="mbrn:26244341"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="252"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="491" mass="55918" checksum="E425D2B4624DEFFC" modified="2021-02-10" version="1">MSDDEDFMQESDEEQYDFEYEEDEDDESGDVDIENKYYNAKQLKLTDPSDAIGEFLGIPPLEEEKGEWGFKGLKQAIKLEFKLGKYDEAADHFAELLTYVKSAVTRNYSEKSINNMLDYIEKGANGKEAAKSMEKFYSLTLQSFQSTNNERLWLKTNIKLAKLLLDRKEYSSVSKKLRELHKACQRPDGTDDPGKGTYSLEIYALEIQMLAETKNNKQLKALYQRALKVKSAVPHPRIMGIIRECGGKMHMSEENWKEAQSDFFESFRNYDEAGSLQRIQVLKYLLLSTMLMKSNINPFDSQETKPYKSDPRISAMTELVDAYQRNDVHAYEKVLQGHQDILDDPFIAENIDEVTRNMRTKGVLKLIAPYTRMKLGWIAKQLKISQPEVQDILGFLIVDGKINGTINQQDGILEIASDADIKRIQAMSSLSASISELFGAVFNEGDGFRSKERDGSFEQSMDFQGLSMGRALRGAGQQRAKKGKIPSAMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3G1</accession>
    <name>A0A7D5Z3G1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sorbicillinoid biosynthetic cluster transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sor3_0</name>
        <name evidence="7" type="ORF">G6M90_00g019820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548561.1">
        <property type="nucleotide sequence ID" value="XM_014693075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3G1"/>
    <dbReference type="GeneID" id="26238005"/>
    <dbReference type="KEGG" id="mbrn:26238005"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="747" mass="82601" checksum="C7E8E8A241871611" modified="2021-02-10" version="1">MDTHLPTGAPLYFGPRRPKRLKIDVACDTCRSRKVKCDGARPACGNCSKRFGQKDHCRYSNSDGTPAAPHKDTSPSTYTDWPPAKNEPQQQPHPAQVSNLTNHHVPPGGDPYPSRNCQEPHSSSQVSTFRPVLPGPSPGKGSADVKHAIPRDKRTAAISDAGSVRAPDASPSAIDSMTAVVDDDVSTGEFFGSSSAGSFTSQIKAAVASRLGQAQPKPARPGLSLGVGNLNAPRRAGMHNSANEVLPPRRQADHLMNVYWFYVDPLYPFLDRRKWEQNYANLFAGTPIDTDEVIFVATLNIIFALATQLVESMEPENRDETSGVYFKRAKDLLDLTFWDSGSLELVQYLLLMSQYLQSTNLPHQTWMIVGSAVRVAQSLGLHLPETSALQPTTSQRELLRRIWHGCVLMDRMVSLTHGRPAMISRNLASAVPLPLTSSNAKPNDYGRLTEGSFFVKSIELYEITHRVLLDLYSEPGSRPRSTIHDDRKDEDLAAVMQLDSAMMKWEESLPKFLVLSDADVANNEVSHRQAVILHIRFLHARMLLLRPVVARVCLPPPGFGVAAARPPDSLQSRVMQQCTIYCVEIARSIISLLLKYQANDGTVGLLPAWWYRVYYLFSAATVLIAAKLRTDIMNLQDINQAWSEVMKVLQAHEHVNTSARRCVAALQILSSKILNGGASTMDSSAHFDTTVSPMDSSVPHVGGIQPAVQQDQSFSQFPELDIRDLTFTVDDFSWLNDMNTWNVLNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z411</accession>
    <name>A0A7D5Z411_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PXMP2/4 family protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PX24C</name>
        <name evidence="7" type="ORF">G6M90_00g094710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540834.2">
        <property type="nucleotide sequence ID" value="XM_014685348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z411"/>
    <dbReference type="GeneID" id="26246447"/>
    <dbReference type="KEGG" id="mbrn:26246447"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="25476" checksum="77783803F5D68F8F" modified="2021-02-10" version="1">MSCTTSRRRWFRTREHMSGKPLGICDMTLSPIAVATLQATGLSTASNMCAQFLDHYQQQRPFSLDPLQLLRFLLLTLLTTPPNYHWQQFLERRFPAHIPTRRPYEAIELQQIVEEGGERQARPPEAFSYRNTLTKWFIDCITLGAVLNTVAFLVIMGVLKARSPGSIWQSVVDDTVPIIVAGYRIWPLASIVSFSVIPVSKRIVFLSFIGFLWGIYMSLVAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z439</accession>
    <name>A0A7D5Z439_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nahG</name>
        <name evidence="7" type="ORF">G6M90_00g007250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549785.1">
        <property type="nucleotide sequence ID" value="XM_014694299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z439"/>
    <dbReference type="GeneID" id="26239229"/>
    <dbReference type="KEGG" id="mbrn:26239229"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="436" mass="48057" checksum="A84A9EF883239DF9" modified="2021-02-10" version="1">MSKPFHIVIVGAGPAGLSTALALAKQPPVSSSPLHITVLELRDGVQTLGGAVNLTPLALRYLDWLGAGGKLRPQASTVSAIELVAHRTGGLLGRLWPDVDAIRAQRQLLVEALRDAIYELSTGNQDPKVDIIYDAKINEMREFGSMDNGGLEITYVKTGASPGKHTLEADVIIGCDGIHSQVRNALVEPSRKKTYSGKCTTYGYADLRKNGANPSELVKSWVRADGCPLITDTTLVTKGNEALLLTYYEPSHEKLYLAFVNPMTEKEDAREGWSVHGADKEGIKTSIRGTFQGGALKCLGEIIDLCEEWFFFPVYMLPQEGDWCKGRAIVIGDAAHAMPPQGEATGVAIEDGVLLARVLSRRATRDIPTLFRDYETLRRPDIQETYKETMARWNAPVPKAWMSGFIMDWMTWGYLKLMGMKKDYFGRDVRNMELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4B2</accession>
    <name>A0A7D5Z4B2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g087660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542349.1">
        <property type="nucleotide sequence ID" value="XM_014686863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4B2"/>
    <dbReference type="GeneID" id="26244863"/>
    <dbReference type="KEGG" id="mbrn:26244863"/>
    <dbReference type="OrthoDB" id="4961185at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029014985" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="17975" checksum="A986CF37E180679E" modified="2021-02-10" version="1">MKISSTAILALAAAVQAAPEPQPDIWGDITSGAGGIISDASTFVDGVKSHASTWADGASTWADGAKSQASTFVAGVNSDASSWADGAKSHASTFLAGVSSDVAKATSEAGAKASSLSQFIATATGSAKSSAESELSKVTSSLAAATGSSASASRTTSSSTAGGAYGPAPTAAMAVGALMGGAALFANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4C9</accession>
    <name>A0A7D5Z4C9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dbp4</name>
        <name evidence="17" type="ORF">G6M90_00g045960</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544723.1">
        <property type="nucleotide sequence ID" value="XM_014689237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4C9"/>
    <dbReference type="GeneID" id="26242064"/>
    <dbReference type="KEGG" id="mbrn:26242064"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
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    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="81"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="281"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI66508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="796" mass="89644" checksum="31CC5C943A6FCF7A" modified="2021-02-10" version="1">MATLTPGRHQKTQRHAKPDSRQQKQKLHQEDLQKLERAVNDLDAKSEDIKTFSDLPLSQPTIGGIKASHFQTLTEVQQQAIPLALKDNDVLGAAKTGSGKTLAFLIPVLEKLYRAQWTEFDGLGALIISPTRELAVQIFEVLRKIGRYHVLSAGLVIGGKNLKEEAERLARMNILVCTPGRMLQHLDQTAGFDANNLQILVLDEADRIMDMGFQSAVDALVEHLPKSRQTLMFSATQSKKVSDLARLSLKEPEYVSVHEAATSATPTNLQQHYITTPLPEKLDTLYGFIKSNLKSKIIVFLSSGKQVRFVYESFRHLQPGIPLLHLHGRQRQVARLEITSRFTAAKHSCLFATDVVARGIDFPAVDWVIQVDCPEDVDTYIHRVGRTARYQSKGRAVLFLDPSEEPGMVKRLEQKKIPIEKVNVKEKKKKSIKNDLQNMCFQNPDLKYLGQKAFISYSRAIHLQRDKEVFKLDKLDLDAFASGLGLPGTPQIKFHKGGDIKKIKNAPRDGMSSGSESDMDLDGEYGKTKKKDKKKPEVRTKYDKMFERTNQDVLSSHYAKLVVDGGNESGSDDDFLSVKRRLSDDDLDAEIQKGHNSNVKALYSLGGDEPYVIDSKRREKALQSKTKMLKFRGNPTKLVFDDDGESHEIYELQNEEDFKRAGPADEQRQTFVESESARVKAADVDDKQLAKQKKREKREKRKAREREELEGDEAPMLVDAPDGEDPLALLRSLPTAGEQSDGEPPKKKAKKWFEDEDDDDADNKKKSRRKGKVLQVTEEPETLEDLEALATGLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4F5</accession>
    <name>A0A7D5Z4F5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g019590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4F5"/>
    <dbReference type="GeneID" id="26238027"/>
    <dbReference type="KEGG" id="mbrn:26238027"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="923"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="468"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="406"/>
        </location>
    </feature>
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        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="958" mass="104644" checksum="DEBFD40B2D9429E3" modified="2021-02-10" version="1">MAPDPTSIDNSNDNSNTNTNTASTPNRKTKKRVVWHSSSQDYGKAEAEGTSPDSPADGGGTTSTNTSLAPASTNAAAAADSTLHSTVATSTSNSGNTSGNGSGTPIPILGVKDLRSEPGSPGLFSTPPGAPDAVELRMALNLVLTEEESRREEQSFLSVATPRAPRPALRRNTSYDDPEERERADQAESRVTERQLRSMNDARQRADRLAVSVGSYSASGSRRNSDVEGSFQPLIRDSDDHGSSFADDATVTSDDDLDKERFRYRTPYSRRQRFIEDHDTAESLVRSHTQKAGKSNLFHEEPGSSGTNTPVSRQTYGNDYVPRPSKYRGGILSSLLKLYQDDRRAPGNNTSGQLTPLSSSTPVMSPRPSPPTSRPPSEAGGSRPSSRAGGSRQRFTSGLFTNNRARHSTTSLTELVKSSSMFAAPGSSEISDHWSEKFKKEKADKSPKPKKEQIRITVHIAGIIARHRYLLKLCRALMLYGAPTHRLEEYMTMSSRVLEIEGQFLYIPSCMIISFDDSTTHTAEVKVVRVPQGIDLGKLCDVHNIYKDVVHDKLGVEEATDGLHKVMERKPKFHTWFRVLMYGIASACVAPFAFEGRFIDLPVAFILGCIVGMLQLVFAPSNELYAHVFEVSASVITSFLARGFGSINNGQLFCFSTLAQSSIALILPGYMVLCSSLELQSHNIVAGSVRMVYAMIYTLFLGYGITIGASLYGMMDSNATSETHCKDPLDRNWYFLFVPGFTLCLCIINQAKWRQTPVMTIMALAGFCVNSYCSKYFEGNSQISNMLGALTVGILANLYSRLGRHMENAWLDVVEWWQYRVKPRFSRHRCRDPDAWSLPSMSDPESNTASQKKQWRQPRKVGYSLAAAAMLPAIFVQVPSGLAAGGSLLAGITSANQLTGNSTSTVDTSAKTIGNLDGTAFNVLFSVIQVAIGISVGLFMSALIVYPLGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4P5</accession>
    <name>A0A7D5Z4P5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g057310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544315.1">
        <property type="nucleotide sequence ID" value="XM_014688829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4P5"/>
    <dbReference type="GeneID" id="26242727"/>
    <dbReference type="KEGG" id="mbrn:26242727"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="514" mass="58713" checksum="FEDD2150CA4073EE" modified="2021-02-10" version="1">MPIVLMRRKIVLAVGVALVLAALLYTSGHLDTSRFMNTIRPLNKSNGQEKTSRLHFLVPASVSNLRLCYNLVSAAVNRYPVPTLLGWNGQGELDAAQTHLAKLRTMKRYLDSLDPEEDDDLVIIVDGYDIIQQLPVEVMVERYFDVAQKADIHLAKRMGISVTKLHERDMKQTVFWGPDKICWPQDPAAGRCWAVPPSFLAENAFGTDKGPHDIFAKDPRWLNSGTVMGPIGDMRKVIDATMDEIAATHNAYFRHSESDQYYLANVWARQEYWRSKQIANGSEVKGGPPNRILPEKISESQETELHIAIEYDSALFQPQAGNDPFLGYLEYNNKSYTSRVHVDMFERGRKFVPYTVQMPNNVRMALMKLYNSIPKTLAGAPAENWVRQVRLATNFVTKQIYGTWHCTGPKDSIDSEFRKMWFYPFVPVLLRESVRSSQKEDIISSNVIDGRRWVAKSVYPRDEKLVGEYGGAWSDEEVGGRFIPWKDMCGDHEDFLFWGQQDTGIQEDEYMMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5U4</accession>
    <name>A0A7D5Z5U4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g058870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986850.1">
        <property type="nucleotide sequence ID" value="XM_066130670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5U4"/>
    <dbReference type="GeneID" id="26242873"/>
    <dbReference type="KEGG" id="mbrn:26242873"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="201" mass="22757" checksum="E6601A646F44535D" modified="2021-02-10" version="1">MWAHAESKLHYNADQPLEDQVRESIEQSFQNLKIDYIDALLLHVPFEDEQDDTVAWHVMESFVPLRVGVLGVSNSSRAALEKLYAAATVKPEIEENEYDANIREYLDKTGIVYQAFSLLQANQEIRSSELVARVAERFYTKREIAFCMLVLGLGKVSIVNGTTSEAREMDLARIAELLGGQQAMADLTEHLAEIKQLLRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5U9</accession>
    <name>A0A7D5Z5U9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g099020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987710.1">
        <property type="nucleotide sequence ID" value="XM_066131554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5U9"/>
    <dbReference type="GeneID" id="26240869"/>
    <dbReference type="KEGG" id="mbrn:26240869"/>
    <dbReference type="OrthoDB" id="5395975at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="44798" checksum="F8AB7360C9436123" modified="2021-02-10" version="1">MEPHDVEILVHVTSPSKVSDDDTYRHLARAYLAFQPGSRVDIIAPATLLPCPASTPQLPSLNQRHRDLHPLPGPPPESSQDYVTPTVEEAFCPESQDLSFQSAIDNRASPPLRANTRSSLQRRLQIATPSPSSWNPPPSQISDSYPLPDAGIINVTPTRVLQRYLQKTPSSSPPSPKDHARAASPRSSLDLINIPSSIPIPSDNEAPTYPKPDIIPVTPHLPAGLHKRPLQEDDALDITHISNSFVSSPRAESAPPPTKSTKAIVTATTAPQTDVPLARSTSDTGPIRSSDLSAIELFSHTLDIRPPSPETSTVNLDPTSLVSPKLDKLSRDLSTRYKPISARQIDPFERGYWLVDCTSWSDQTRLDTWVFLTNYLRSGLAGGREIKTTGARWFDAEGEVVLEVEGVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5Y0</accession>
    <name>A0A7D5Z5Y0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DPH2</name>
        <name evidence="12" type="ORF">G6M90_00g095190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546811.1">
        <property type="nucleotide sequence ID" value="XM_014691325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5Y0"/>
    <dbReference type="GeneID" id="26241234"/>
    <dbReference type="KEGG" id="mbrn:26241234"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="530" mass="56894" checksum="03AD3EF97C7FD390" modified="2021-02-10" version="1">MASELAAAPVLSTPDDHLLDVPAAESLPTSTLPDDELRSTYEIGSTASQIRQAGWRRIALQFPDHMLVDAPRVVQLLDAQLADDTARIHILADTSYSACCVDEIAAEHADAEVVVHYGRTCLSPTSRLPVIHVYTSRGLDRGAVVAKFGAEFADKTSKVVVMADLTYQDHVDAVVRGLKESGYTNVLGTSVARDPAAVIPNRRIEGPEMTDEAARSHALFHISDPPTSLLLALQTRFASLHVLSTDSSAAVTVDNPTLRAAGLLRRRFARVLSLASAGVVGILVNTLSVSNYLASIDLLRKKIAQAGKKSYTVVVGKLNPAKLANFAEIQGWVVVGCWESGLIEDDVGYWRPVVTPFEMEVALMSEEERIWGGEWWGGIEKLKQEAEASQGGHASQGQDDSAPAEEEDVDGGVEGEESLPPQFDLRTGKLISHSRPMQLTLRGSGTNNNGSEGIDAGNTNRGQSNAVTKRVAGELASINGVASPGAEYLRSNRTWQGLGTDFDQEASTLIEQGRSGVARGYHVGEDESRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z674</accession>
    <name>A0A7D5Z674_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial inner membrane protein OXA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OXA1</name>
        <name evidence="13" type="ORF">G6M90_00g063340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542549.1">
        <property type="nucleotide sequence ID" value="XM_014687063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z674"/>
    <dbReference type="GeneID" id="26244498"/>
    <dbReference type="KEGG" id="mbrn:26244498"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="12">
        <location>
            <begin position="120"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="46031" checksum="43E09FAFBAB6710B" modified="2021-02-10" version="1">MLGGVSSSRQFSLWGYGKKKTPEEEPVASKPETTTTTSEAGRPVDPTPENVVPSPPTEPAVPASEVDLSSISDIVNGQDILNMSEQIGYLKALGLDFGTGPTSVMQWALEHVHIYSGLGWGASIMATAVLLRCIMFYPQVRSLKFNAVMQNLRKDPRSQEAMKLVQQGFANQDNEMRQKGQYLNKMLKEQYGVNNWGMLWSFGQIPFTFGLFRIVSGMANVPVPAMETAGYLWFTDLTATDPYFILPAAGTALMVGALAINAKHTPESQKKMLKTMTYVFGAVGFIGTTFLSAAVNLMTVALGASTLITAIVLNNALVRRTVGLPPHPTASSTAPQKTTYEAPRAANTPEPGLRERLESSLNDMKKGMSDQITNYTGTYSGTDEEKAERKRKELMRKLEDTRKQQEREEFEKKYKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6B7</accession>
    <name>A0A7D5Z6B7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase FCK4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539992.1">
        <property type="nucleotide sequence ID" value="XM_014684506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6B7"/>
    <dbReference type="GeneID" id="26247212"/>
    <dbReference type="KEGG" id="mbrn:26247212"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="54067" checksum="5B57BB9EBEF17B39" modified="2021-02-10" version="1">MGSQAESPMALRQLGPIELFSSARHYMRLYLSVTVTCRYNAPTLGRGIDEALLYPALARVVSAQPMLRVGILGEDTSKAAFCHIKTIHLANHVSFETLDDCETVDQYNEHIASQQGWHHSRPWLNIQDVPPWRIAVVKPSPAATGELSRAQEIIFSFHHSLLDGNSGKLFHENLLKELNHQLGQDAANTTTTASLQFPDAPRLPEAQDQIIAFQNSPWYLVKTLWNELGPSILRAKKHVPWHSKPSDFSIPYVTLTKAVDFQGPIVAKLLKACRQHGTTITGLFHALAAASLASRLPAGEASSFAASTPISLRPFLGPAANPEFKQSLRVLVTSQEHQFPAPLVARLRTPKDADQSIWETAQRVKGELNRKVASVPRDDINGLMKYNSDWIGYFKKKDGQPRPDSWEVSNIGVFANPSEEAGFAVSRVYFTNGALVTGSPLALGLGSVAGGLLSVGISWQESVVGQEFVDGLAGDLTEFMTRFDETGKFVVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z781</accession>
    <name>A0A7D5Z781_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional activator protein acu-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">acu-15_2</name>
        <name evidence="10" type="ORF">G6M90_00g100980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546249.1">
        <property type="nucleotide sequence ID" value="XM_014690763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z781"/>
    <dbReference type="GeneID" id="26240672"/>
    <dbReference type="KEGG" id="mbrn:26240672"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
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            <begin position="1"/>
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        </location>
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            <begin position="612"/>
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        </location>
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            <begin position="689"/>
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        </location>
    </feature>
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        <location>
            <begin position="615"/>
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            <begin position="705"/>
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            <begin position="734"/>
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            <begin position="756"/>
            <end position="765"/>
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            <begin position="777"/>
            <end position="794"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="QLI73583.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
    <sequence length="910" mass="101474" checksum="B688394E0153AC0B" modified="2021-02-10" version="1">MDPAHIFRQGLGSVPSRPNQPYTAHYQKPQRSNDDLSDDDGSGHRVAHTLTACCRCRQRKTRCDPSLPRCLPCERSGSICEYLDTAKGKKINRYYVIKLQDRVRALEAELAHYTDDENDYPKTTEDIVRPGGMIRLKASDETSRYLGPSSGIAMTRLLMEEAKRYTASNRISDLIPEVRARSQARMQSIQMTGPPNGRKKSYPMLSEGPADGLPSRATMDKLIELFIQKSQVFWPVLHEKNFERDMEAVYNGDEDPYKNFVLRMVIAIALQKFDSQYAGLADSYYLAAMQYAEAVIRPKDLRTLQCLVLIGHYSLLTPTRTPVYYVIGLATRICQQEGLTDEQTITTGYNLDEQTIDMRRRLAWIVAVMDFGLSYHMGRPSGFATGNDKVDVSIFSTVDDEHITANGISAGPTSPRKAFAAHFYQCRELQAEIRRNLYEQKRHQPNNDSYPWFDSIEKKMKSWLDAAPSHIQWGPSWCATFYHHTRVVLYRPSPQVPQPSARAATICFESSAFVINLAEKQMSSGFFSITWLLLLMLTSCLNALLWSTSYPEVRQAHSRQEVEDLVARALACLEKCAERWPGTRYTAQLYNVISKACLQSYDRAPDSQHPMFSFASPSSVAEPQSSPDSYVQTGPSQQLPYLNPPQFGFVFDSPPESMNAYTFDPNYPPPQPTFRSNSIFCNPATDANGRRFSYFPPEGSPEDNPAQSVMSHNQTTSPSVDHSRQIPTPPDSIPTGTMSAATPNTTLSPQNLPLQSSALSDASSAPRVVPMQDHISPPQSGQPTQVTPNFTTARPSVPQRPLPATTSAADWFSPPAPFISPYNFGPMSSNCFNDAMPNNFAEVPTGSLGGLQNMATGFDAHGQYGFMPGRQGSLTHSQQLELMNALETEGIGDIDAFLNAGNNMADVRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7I0</accession>
    <name>A0A7D5Z7I0_9HYPO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">G6M90_00g098400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014691018.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26240927"/>
    <dbReference type="KEGG" id="mbrn:26240927"/>
    <dbReference type="OrthoDB" id="3880401at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26278" checksum="BB5714CA0F22CA5D" modified="2021-02-10" version="1">MDPNNKPAPYQVPELLFHTILTVIDYSHDASGASRTTFVLGTHGTLEAAKAFAAQSLETLNFKPDDFQKYNVRSSGEEAPGKTWIHGDGVLAFARSFDGQELRVSIDTTPNNESLYASTEDGKMRLPEGAQFLHYMVQTMVDYNVDRSGSLQRTEIQGVYVHRADAWTAAHKCLDRSGYAEYDCRGDAEFVEQWPFGENVAVHAVSETGQNYLVAVNTPPQHKHDIKRHGRKKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7T5</accession>
    <name>A0A7D5Z7T5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar segregation protein pep7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pep7</name>
        <name evidence="9" type="ORF">G6M90_00g074030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="195"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="337"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="547"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="667" mass="74318" checksum="685F6E0AE1E6F99B" modified="2021-02-10" version="1">MSGRKLGGGRILGSGKGLAPPTPPSVPRSASPLPPSESTASMGSISMSPPASASLPELGQDIGASISVGSQRKKNATDATGLVCPICNEEMVTLLQLNRHIDDSHQELPEAAQDEVKTWFDKQVLKAKRFQPLSLINQKLRGLEVFESNESHPISAPATAAGKAPLETPIDPDDLITRNHWQRPTSHDLCTDPACGKRLGPMNGNINCRHCGRLFCEEHTMYQMKLSRSANHEPVRGYWARVCETCYKSREGYNDHNGVLVDHMKTFVEIRMKKMERQKLDVSRLEKRLSKLTRILANPPEKLPSHNGSLLSPVSTLTGQKNNRKLIEQSLVTWEDDEKVSKCPFCQQEFGSWTFRRHHCRICGRVVCADSQTGCSSEVSLNVAPAPPRNGTEKPETNGENSLALNIRMCRECNHTIFSGRDFTESLLHKPPDQKAYETLRQFERGIRQLLPSFHRALQALQTPTLPNGEMDLSVPPPSHAQIQEAGKIRRRLIDSFGKYGMAAKRLRDLKTDSPTQQMLQQAVYSQTNNFLHTNMLPLKSLPQVLRHRSTPSQSSRFLATPSQSTSSLRHSELASDAGSQAASESSTIVSQLETEEKDLKERLAILEEQKFMVEEMIRSASGARRFEEVGALSRNVDELDQEIQQLKTKVGDVEQKWEGVYRNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z910</accession>
    <name>A0A7D5Z910_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline utilization trans-activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PUT3_1</name>
        <name evidence="8" type="ORF">G6M90_00g067750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987105.1">
        <property type="nucleotide sequence ID" value="XM_066130858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z910"/>
    <dbReference type="GeneID" id="26246639"/>
    <dbReference type="KEGG" id="mbrn:26246639"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="254"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="642" mass="72353" checksum="0A38EA4206B7CFC4" modified="2021-02-10" version="1">MPLQADTRRARRTPNAHLTSPVSTSDGQSNLQAEECPDVAIQPQSEPQSEPEFRLRTDPFVIPSRTIPNFQRNRRQWIWLSPWSTWSFTVRLMLTLGEKLRPGSSSLPQNVLDTEVYEFPWPSFSASEINISGLPSLNHALYLFTTMKFHLGQTYRLFDEVEFESEIKDFYANAVQNVSEYRVWFIKFLLVLAFGTAFHTSHTTAQEPPGSRFFSRAMALMPGPGCMWKESMLGIEILAMAGLYLFCIDDRESAHCYLSNAIRIAQMEGLHTQLPQEELGAEKVTHCRDLWWTLYIMDRHFSSSLGLPMSVQDGDITTPVNPPNVGSQSDSARSLQVNLSHLMSIIVTTVYLPARTPLTSFLEQTRSILHTLAHHAQEIERIIRLKFDNSPGAMPRETHYLTMLYHQCVIFATRPPLLAALKERSELLGHPDDENWDGFLAQTATVISAGIKSAAKTLQILSKEYSMLEVFLPYDVEFAFGAALHLTMASAVFPDVVDYQHCRHLSRQILHELVSRGNRIARARTAELKYLETLCAELAVQGRRQGHQTLTLSHLESEPMDTWGADAGNEARLSVGDQNLGAGMPEPDVSLQDLGHNTSSNMDLLNSIGISADNFFSIIQQMPDPETLSESILDWDLWKEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z949</accession>
    <name>A0A7D5Z949_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyketide synthase-nonribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ccsA_0</name>
        <name evidence="8" type="ORF">G6M90_00g063930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986865.1">
        <property type="nucleotide sequence ID" value="XM_066130768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z949"/>
    <dbReference type="GeneID" id="26244441"/>
    <dbReference type="KEGG" id="mbrn:26244441"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="845" mass="92900" checksum="60870D1A97FDBFAA" modified="2021-02-10" version="1">MFSSIAAAAGNRGQSNYSAANMFMVATAMERRRQGFAASVLHLDAVLGVGYIMREFDETVLPTILRGGFMWMEERGFHQCIPEAILAGRPQAGRNPEIITGLRRINADVAEPVPWIRNPRFQHYINWGGDGNLKKMMQNAAVPVRARLFEVRNLDEISKIIQDGFVGKLQAALQLQQDDNSEQFNMSNMSADDLGIDSLVAVEIRSWFLREMDVDMPVLKILGGASLVDLITFALENIPSELIPKLAAVETQPMASNESELQKTQLMPLVASSGSNGSVLASIDNLSRSAESTIASSSSESPLPESESEPGDEGLKSRSFEHKSVLPHEVERSVPMSAGQSRFWFLNHFVQDQTTFNIKFSIKINGELNEHKLEAAVKVLGHRHEALRTAFITEGDQNLQCVLKNSLLRLEKRAIRDISQVNREFEYLRDYIYDIQHGETMRMLLLSLSSEQSFLVIGYMHPAIIIPIQDVPLTSNGKLDRAAIEKLQVSNGTERATGAAKLGNVECELREAWEEVISEEVLQHCTIDRGSNFFHVGAMAAVITDATYLEAAETDWTEETALTKHVVDAGPFISAATKSTRGVIIMTGATGFLGLELLKEFVESPSVTKVHCIAVRSQGKLGLFLGSPKVTLHQGDLSAPRAGLSVQAAEAIFGEAGATVHSGADELARLALVHNVPFHYNSTTATGRLNNMDTLYEISLAENIPPPGYSDGYVAGKWASEVFLEKVHERLGLPVCIHRPSSITGPAASDLDVMNSVIKFSRQLKAVPTSSRWRGSLDFISVENAAKGIARVVTGSDQETKLKYLHHSGDVIIPIDQLGQHMQEEDGIEYRELSLWDWTELAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9D2</accession>
    <name>A0A7D5Z9D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular metalloproteinase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541102.1">
        <property type="nucleotide sequence ID" value="XM_014685616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9D2"/>
    <dbReference type="GeneID" id="26246091"/>
    <dbReference type="KEGG" id="mbrn:26246091"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8398" checksum="F49F88F466C09334" modified="2021-02-10" version="1">MPATDALQPSLTKAERQICKEYGGWTNFMQSMGLKPWDSDDAEEGKAILAAFARRDKEEEDKAANNKTNSSSGSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9Q9</accession>
    <name>A0A7D5Z9Q9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g086160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541174.2">
        <property type="nucleotide sequence ID" value="XM_014685688.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9Q9"/>
    <dbReference type="GeneID" id="26246163"/>
    <dbReference type="KEGG" id="mbrn:26246163"/>
    <dbReference type="OrthoDB" id="4939962at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028915882" evidence="1">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8582" checksum="54ACAB568F09CE3F" modified="2021-02-10" version="1">MSLIALLGALVGWFGAQKLSINKPAAISRQIQQAQVMEKPCGETPAEARTRGCYLDVISFCWLPERCYDAELSQHLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAE8</accession>
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">4556</strain>
        </source>
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            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
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            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
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        <property type="protein sequence ID" value="QLI72428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI72428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="199" mass="23155" checksum="9CF97E55FC4C8328" modified="2021-02-10" version="1">MIEELPDIRKFSAMLAKLHHQSVVNKNAPKEFRFHVMTRKSTMYQDISWFSQGPSKELDQILPEFISNVSPRLLRPLETRGRTLKPVALHGDIWHGNLAVNANTGEPVHFDASIFWGHNEYDVGSMATPRYGVGQDWIVEYHKFFPVSVPEEDHEARDVLYAISGHFCASTLYPDNKPFRSTDERENMMKRRREEVRTR</sequence>
</entry>
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    <accession>A0A7D5UPK9</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g027750</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="212" mass="22941" checksum="A946B45CB547565B" modified="2021-02-10" version="1">MAPITCKVVDANNRGRPGVYVVLECKDQLHRGIATLESLTDEDGGISLWFPTPSPGRTDDVEPQIVDSSNIPRVSLTFFPHTVPSTCPGPFLSIHTDLYLQGDECHGITLYLDPHPRLEHSPVPVASPLNRFAAAAVSTQEPQRDLSTPSPLLLPPPVMAVVSLTNATRAITSMGFTAVIGQGVIYGWVIFGAAICGFFSMVIVLVYNFRQE</sequence>
</entry>
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    <accession>A0A7D5UPS4</accession>
    <name>A0A7D5UPS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomally synthesized cyclic peptide ustiloxin B precursosr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ustA</name>
        <name evidence="2" type="ORF">G6M90_00g015680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028947658" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11592" checksum="7277F88DCBFD3EEC" modified="2021-02-10" version="1">MKFSTAIVVTALAVGAAAAPTPGKTVEDYFIGADKRDKTVEDYFIGADKRDKTVEDYFIGADKRDKTVEDYFIGAEKRDKTVEDYFIGADKRDKTVEDYFIGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPS9</accession>
    <name>A0A7D5UPS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded DNA-binding protein RIM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RIM1</name>
        <name evidence="3" type="ORF">G6M90_00g014740</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="137" mass="14793" checksum="59EBA5C3211B1CDC" modified="2021-02-10" version="1">MSSFLLRRATVASAGAARSFSTSSPRSVARISIIGNLADTPEIQPTSSGREILKYAVASNTGPKDNRQTSWFRVTSFAEGPRKDFLLSLPKGAMVYVEGDATISTYQDPNGQTRSGLNIVQRSIEVLKRPQNAGQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPU8</accession>
    <name>A0A7D5UPU8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">External alternative NAD(P)H-ubiquinone oxidoreductase B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NDB2_0</name>
        <name evidence="7" type="ORF">G6M90_00g014980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549027.2">
        <property type="nucleotide sequence ID" value="XM_014693541.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPU8"/>
    <dbReference type="GeneID" id="26238471"/>
    <dbReference type="KEGG" id="mbrn:26238471"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="46"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="37746" checksum="6AACEFE097F1FA1D" modified="2021-02-10" version="1" fragment="single">MDGLTRIQCRSLMKLSSHVPRAAAHAISRRHASTLATTNAPGTKERVVILGSGWAGYAAARTLSPSKTTRILISPRSHFAFTPLLASTSVGTLEFRAAIEPVRRLGLDEFHQAWASSIDFKNKTIRVEANLRGDVSAATNRPEIKGEEFDVKYDKLVIAVGCYSQTFGIEGVKEHANFLRDVGDARAIRLQVLQAFETADLPTTSDEERKKLLHFAVVGGGPTGIEFAAELHDLIKDDLSRMYPKLQKHCAITVYDIAPKVLPMFDSKLAAYATETFKRQGIRVKTEHHLTRIRRQGHVLMLQIKEEPEEVGAGIVVWSTGLMQNPLVKTLVESDIEGVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQI7</accession>
    <name>A0A7D5UQI7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g010490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549469.1">
        <property type="nucleotide sequence ID" value="XM_014693983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQI7"/>
    <dbReference type="GeneID" id="26238913"/>
    <dbReference type="KEGG" id="mbrn:26238913"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="44619" checksum="BA3ECD7A63D843E8" modified="2021-02-10" version="1">MPGKIRTAQTVSFDVPAAEQPGLHNRWHPDIPSIGTIKRGETVKIECLDWTGGQIGNNDSADDVRDVDLTKIHYLTGPFDIQGAEPGDLLVVNITDIQPFDHAPWGFTGVFDRNNGGGFLDRHYPRAAKAIWDFDGIYCSSRHIPGVRFAGLIHPGILGCAPSADVLAQWNRREAELISACAQSMPGQIVAQPPNEANAHAGQADGDLRARIAREGARTIPGRPEHGGNVDINNISRGSTTYLPVHVPGAKFSVGDLHFSQGDGEISFCGAIEMAGVITIRFDLIKNGMKERAIASPVFRPGDVQQLFGPSRYLTFEGFSVDEAGKQHFLDATVAYRQACLRAIEYLKQFGYSGEQAYLLLSCAPIKGSIAGIVDVPNACTTLGLPMDVFQFDISVEAERVKRDLGACPVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQK2</accession>
    <name>A0A7D5UQK2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g020380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985714.1">
        <property type="nucleotide sequence ID" value="XM_066129853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQK2"/>
    <dbReference type="GeneID" id="90967485"/>
    <dbReference type="KEGG" id="mbrn:90967485"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7727" checksum="E63615B1DB040AB4" modified="2021-02-10" version="1">MASTMKAVNYNGPFKVKVQEVDLPKIQHPDDVILKVTSVCQPLTNSARSCSRMYQQQLTSKAAICASDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQP5</accession>
    <name>A0A7D5UQP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">chit33_0</name>
        <name evidence="20" type="ORF">G6M90_00g000450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985730.1">
        <property type="nucleotide sequence ID" value="XM_066129487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQP5"/>
    <dbReference type="GeneID" id="26244395"/>
    <dbReference type="KEGG" id="mbrn:26244395"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028895331" description="chitinase" evidence="17">
        <location>
            <begin position="24"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="19">
        <location>
            <begin position="31"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="18">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI64291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="42460" checksum="E7D647B2D9B88131" modified="2021-02-10" version="1">MTFPVQTWPSIASILALLPATLAGFNSGSGKNVAVYWGQNSYNQGSGPLAQQRLGYYCSNTDIDIIPVAFMNGISPPITNFANAGDNCTAFPSNSNLLSCPQIEADIKSCQATNGKTIILSLGGATYGQGGWSSVSAAQAAAQNVWDMFGPVPSGKAIDRPFGSAVVDGFDFDFEASANNLPAFGQKLRSLMDAAGGKKFYLTAAPQCVFPDAAVGAALNAVSFDFIMIQFYNNWCGVSNFQEGSTTQNAFNFDVWDNWAKTTSPNKNIKLLIGVPAAPGAGGGYTSGSKLKAAINWSQKYSNFGGAMMWDMSQLYSNSAFLGEIVSDISNGPTTTLPPGGTTTTTTTTATTTTTTTTSSTTSPAPTGTLVPQWGQCGGEGYTGPTQCQPPYKCVYGGQWWSSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR17</accession>
    <name>A0A7D5UR17_9HYPO</name>
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        <submittedName>
            <fullName evidence="4">F-box only protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fbxo9</name>
        <name evidence="4" type="ORF">G6M90_00g028070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541354.1">
        <property type="nucleotide sequence ID" value="XM_014685868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR17"/>
    <dbReference type="GeneID" id="26245989"/>
    <dbReference type="KEGG" id="mbrn:26245989"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="210"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
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        <location>
            <begin position="153"/>
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        <location>
            <begin position="435"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="517" mass="57532" checksum="24F22AE94EA23A69" modified="2021-02-10" version="1">MEESNGLGPELESFRQQWLSEVRTKKGEQSTQPQLRNSVPSASTAPPPPRKSMARRPSPAKSRKAPPAAEEEDEYLHGRSFDDSPEPSGNTIDGSVRMPPERELVSALDHYEEAMEKEALGNMGDSLKLYRKAYRMDHGVHRRYREKHFPQHKQPQTAPTASSTQITSTDATPAGGDAPVLLPIKDLIASFAGLQIETAPPETDGTPPAPCPLSCLPSELLVHIMQDVAALDVGDFARLSLVCKPLAYLAATEERTWRHVCLGARFGFAAMHRRWSKTVEWEALDEDDGPAGTTTEDAAATASLVPVPYASWRAMFRGRPRIRFNGCYISTVNYVRSGQASTNQATWGGAPIHIVTYYRYLRFFRDGTAISLLTTLEPTHVVHHLTGDLLRLHRDSDNAHAHLPSAAMQRAYKGRWRLSLGPGGDTDAEQAGPPRGEEGDEQLREGDVTVETEGVDPKYMFRMDLSLRTAGKAARNNKLVWRSFFSYNRLTDDWAEFTLKHDKAFFFSRVRSYGVGE</sequence>
</entry>
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    <accession>A0A7D5UR72</accession>
    <name>A0A7D5UR72_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">G6M90_00g022640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692804.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR72"/>
    <dbReference type="GeneID" id="26237734"/>
    <dbReference type="KEGG" id="mbrn:26237734"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="160"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="332" mass="36033" checksum="F0850F4AEE7EE367" modified="2021-02-10" version="1">MERGYVRELDLSNCGPASVATRVGVVPGLRSSAAFFTFLRANLALSPSALSSNYNTPYLEPFSPQPPQLQPPSPSPPAASSEPPLAPIDDIPPLSLDALKSQNDKLDGLRLVADSVSEMRHRASKAVVLHPLCLAAVAAAHMAIYQFVYIPSRDVSRALMLVSGITMIYMATIRFLTSGYDTLAERMGCEDWLRADFGSEDDIILGARMGEDLVGAVVLRLEPKRAPSTNPKRKSRSRSASLRGGKGVIRAWTTKPGYRGQGVGKKLLREAVRLARDRCGKDAQVGFALEHANSTMLLPAMFNKAFRKDEVCAAKALQGAVAEWDLAKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US29</accession>
    <name>A0A7D5US29_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g022680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692800.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26237730"/>
    <dbReference type="KEGG" id="mbrn:26237730"/>
    <dbReference type="OrthoDB" id="5239396at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="151" mass="17517" checksum="5691574CBDB1B1FB" modified="2021-02-10" version="1">MDMLEPYEPEFPSPLNPRRTTPVRAREARARTNVSVSPTQRLLRYRAAEAWRSHKMLQEAREYERRLRETIAWREEAAGLRADGKRQLLDGLDGRDARAEQGEQGETEHQSHGPALSFLTPRRVALAVGLMRRFPVPGWFRCERPPQERAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US70</accession>
    <name>A0A7D5US70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g016430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548885.1">
        <property type="nucleotide sequence ID" value="XM_014693399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US70"/>
    <dbReference type="GeneID" id="26238329"/>
    <dbReference type="KEGG" id="mbrn:26238329"/>
    <dbReference type="OrthoDB" id="88561at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40781">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40781:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17979" checksum="E6BA480D3975361D" modified="2021-02-10" version="1">MVEYRYRYRYFYRVEDEYSQAVTTNFEGISATGRTSINLSATYGDQADVLRWNLQNHLNWRSNYESPFISVYDDEDVAFSIAEGRKEKLGRQHVTVTKIDVSKVHGQIEFRELRPLAERLGVWIPDKAYHNSEREWIFLHDIPDEAVVGVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USG5</accession>
    <name>A0A7D5USG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NMT1_0</name>
        <name evidence="16" type="ORF">G6M90_00g028660</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="5 11"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541300.1">
        <property type="nucleotide sequence ID" value="XM_014685814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USG5"/>
    <dbReference type="GeneID" id="26245935"/>
    <dbReference type="KEGG" id="mbrn:26245935"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="169"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="339"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI65471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="551" mass="61446" checksum="53AD7F11538943E4" modified="2021-02-10" version="1">MPPEESKMAEPIVDKGKQVDQGESESEDDEPAATTSAADTPAGTSTASKKKKSKRKKAKQLLTGKSEEQKQADEVTKAIGGLTPQQMKELVSLNPGLMQELAAASGSSNPSPDQVANMLKNMNLADIMTGLAASGKNVKDMGAYKFWQTQPVPKFGEEGAKVEDGPLKMQKVEDIDKEPQPLVAGFEWVTVDLMDDGEIKEVYELLNGHYVEDDEAMFRFNYIPEVLRWAMMAPGWQRKYHIGVRASQSRKLVAFISAIPVQIRVRDKTFTSSEVNFLCVHKKLRGKRLAPVLIKEVTRISNLDGVWQGLYTAGVVLPRPVSTSRYYHRALNWKKLHACGFSPLPAGSKPEYQVRKYALPETTATKGLREMQDKDVDAVVGLLKRYLGRYNMAPEFAAEEARHWFLPKKDSKQVIWSYVVEDNGKITDFFSFFCVESSIIKNNDVLRVAYLFYYASEAGLSEPFDKPALKTRLNALINDALILAKRAKLDVFNALSLMDNALFLEQQKFGAGDGQLHYYLFNYRASPISGGVNAKNQLDEDHLSGIGLVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USL1</accession>
    <name>A0A7D5USL1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB/POZ domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">btb3</name>
        <name evidence="5" type="ORF">G6M90_00g002640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985986.1">
        <property type="nucleotide sequence ID" value="XM_066129534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USL1"/>
    <dbReference type="GeneID" id="26244192"/>
    <dbReference type="KEGG" id="mbrn:26244192"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18497">
        <property type="entry name" value="BACK_ABTB1_BPOZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000248">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="327"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="627" mass="70800" checksum="D0042D7407165AA1" modified="2021-02-10" version="1">MVLRKHELEGKLGEESEMIKSGELRDENPLDQSDEFNEFLLACRHGDLRKCQEFISQGVNINGKDRFDYTPLIIASLCGHYELVQLLLDSGALAERNTFQGERCIYNALNDRIRNLLLQYDFSKSSDPYVYWSTHISGLLNRSTPTTSDISLTSDSRTFNLHKFLLASRTPYFRKKLEAQPETPSWHLANTVPVEAIQIVLRYLYLGDLPKDLVPAGSPISEEDVVKGLDKISKQLEVDHLWEAILAGNDRRLARQRYQDEEERALKQIGDFFSAKVLGGKMLVDTERVNDVRWKHDNPAFADVLLRADETHDDDEEAQEAPVLNGQGIPIGTGRRPRKSALYPVHKAMLIRSGYFDRMFSGDFVESHRSENLHIVTVDCTPAVLELVLTFLYTENAACPLEHALDLLYTADMLFLDVLKTKAAQAISTLGSGTSSALVDRTHKHARGLANGAGHSEQQAELVEMEPINIYDVIHAAWDLRVQRLEEFAARYLATRLEDYIDESDFQELIRESAERIQRREETDTIELLDDIRYYLSERFRLRFEDAGLDDMMGEDGEIDAEAAVSLAEQGDVMVNGHGVQNGVGGNGVVKTLDGEMAEDEFASDAINYQILLGKIDAMLERLKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USV1</accession>
    <name>A0A7D5USV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 monooxygenase BOA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BOA4_0</name>
        <name evidence="15" type="ORF">G6M90_00g017830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548749.2">
        <property type="nucleotide sequence ID" value="XM_014693263.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USV1"/>
    <dbReference type="GeneID" id="26238193"/>
    <dbReference type="KEGG" id="mbrn:26238193"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="452" mass="50711" checksum="3A1619FA3BD98EDD" modified="2021-02-10" version="1">MVSFWVLNHLSRGLLLYGLCLMLALTLSALLNGLFSHKRNELKARSSRFILIEPFYILKSRLVAWSFLIPGPSIIQTTYEKSNGAPFSVDTPNNTIVLVSDWKHIKEINAAPEGTLSLLGAAKDVLQPKHTMTNFDWTNKRGSDGAPLQMALRAGIKMIEHTLIIAEILRMVPGIVSDPLGKFLSSRLDSGSVMTNALVAVVSERFRDAELRKLRRDIPEKNDCIQWIMDHAPPTQALGPEYVDILREEIEQTGWEAFDKAGGQILPLMDSFLKESARLNPIESVSTRRKVLKPFHFSDGTSVQPGQWVCSAPRAMNRNPETWAKADEFYGFRFVKPEVLDAAQKSISSFGTVLPLAKSTESFTIPEAGKASEYTNLSDWQQWGTGKASCTGRWYAAAAIKTMIGLFITKYDFQLVDPKAKRYFSWRTFIYPYEGTPIALTPRMVLDRDLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT12</accession>
    <name>A0A7D5UT12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxidoreductase ptaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ptaK_0</name>
        <name evidence="10" type="ORF">G6M90_00g001230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542947.1">
        <property type="nucleotide sequence ID" value="XM_014687461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT12"/>
    <dbReference type="GeneID" id="26244320"/>
    <dbReference type="KEGG" id="mbrn:26244320"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="82"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="209"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="446"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="592" mass="66014" checksum="23B1D8281FCC7198" modified="2021-02-10" version="1">MGITFSKRDAATYSAAKVGGKLLQTRTNGKSVLGTLVAPLLPMFLENNPLPNGSPWSLLNHTTDYYEHFPRTGVIRSYDFTVSRGVIAPDGYQRSVLLVNGAFPGPLIEANWGDTIQVTLHNNISSAEEGVALHWHGFLQHGKPWEDGVPGVTQCPIAPGKSYTYSFEAELYGTTWYHSHYSAQYAGGIVGPMIIYGPRTARYDVDLGPVMLSDWYHRDYYALVEETMKPNGRPVRSDTNMINGKANFDCSKLPAGDKTPCHSNAGIARFKFTRGKTHRLRLINSGCEALQRFTIDGHTMTVIANDFVPVEPYDTKVVTLGIGQRTDVLVAADAPPDAYWMRSNISEACSLAGERHAYAAIYYDGADEARQPQSQPWDVPDPLTCANDDLALTKPVMRRRPIAPDLTYDMEVGLFKNASNITLWSFGGVDFRGDYNRPTLLLSALGNHTFEKQWNVKNTQGAKSVRVHVINNTPVAHPMHLHGFNMYVLHEGEGPWDGTIVNRDNPQRRDVVQVRKHGHLVIQFDAADNPGVWPFHCHIAWHVSAGFFAQFLTNPDQVARYRHTMPHVVAETCRQWGEWTNTNIPDQIDSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT66</accession>
    <name>A0A7D5UT66_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g000400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543026.1">
        <property type="nucleotide sequence ID" value="XM_014687540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT66"/>
    <dbReference type="GeneID" id="26244399"/>
    <dbReference type="KEGG" id="mbrn:26244399"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="8">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="29806" checksum="F56FAD322BBE33AC" modified="2021-02-10" version="1">MSLSPAVGEYAKAPANASRSPCPVVNALANHGYIERSGRKIYAKDLNASMRHVGMSPLLGSVFAIPTYFEYHDPAKAYMKNSVSTWQRIWSLIKNPYSYFDYFGCWNASQMSEGRKYLNLVDLASHGAIEHDVSLSRRDIGQKEGNNDAQQDLIEEMLDFSFDGESLTIDDLGRFVKARIQRQLVDNPDLVYGPDEHQVNCGQIALMMGCFGDGKTIPVSYVKAIFEDERLPIEEGWKKRSWWTMGLIEFFGAVKHMVAAVGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTG9</accession>
    <name>A0A7D5UTG9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CDC2</name>
        <name evidence="15" type="ORF">G6M90_00g039280</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986197.1">
        <property type="nucleotide sequence ID" value="XM_066130251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTG9"/>
    <dbReference type="GeneID" id="26239845"/>
    <dbReference type="KEGG" id="mbrn:26239845"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="4"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI66614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="340" mass="39004" checksum="C6C058AA38CFBBDD" modified="2021-02-10" version="1">MDNYQKLEKVGEGTYGVVYKARDLANSGRIVALKKIRLEAEDEGVPSTAIREISLLKELRDPNIVRLFNIVHSDGHKLYLVFEFVDLDLKRYMEALPVSDGGRGKALPEGSSATIMQLGLGEVVVRKFMMQLCEGIKYCHSRRVLHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFRQVPLLLLHSTPEIYSQNMMDEEVWPGVTSYPDFKSSFPKWKRDYRQPLCQNLDQKGLELLEMMLVYDPAGRISAKQACNHPYFEEYLAEQQEEVGRMNGYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTN0</accession>
    <name>A0A7D5UTN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transgelin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCP1</name>
        <name evidence="3" type="ORF">G6M90_00g013880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549134.1">
        <property type="nucleotide sequence ID" value="XM_014693648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTN0"/>
    <dbReference type="GeneID" id="26238578"/>
    <dbReference type="KEGG" id="mbrn:26238578"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21210">
        <property type="entry name" value="CH_SCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="692" mass="77556" checksum="161DA5CDC28782B4" modified="2021-02-10" version="1">MASVTSLDKDLRKLRLDKYTPEAANEARSWIEEALGEKLPSQDLLEGLKDGVALCKLVNLATPPPGTKFKKSPMPFVQMENISHFLRACQSPPLNLQQHDTFLTVDLYEQKDPAQVLQCLGAFSRAAHDAHPGRFPDPIGSRARAAGVISPQISGYASPTGLRGRGTSITSNSSSAYGSKPVLPRRTAGGDTTPTGRRSPTKSPTMTNPASPGPVSSWSKREHEGSTAPAWNIAQYGYMGGASQGNLGISFGGMRQITSAGPHVPSLADKERKRREEAERQEEEERQRRAQQETEEEEARREEERRWEAETQRLREEERRKAAEEKRRWEEQERQWRLTEEMRRKEEQEAEAKLEEERKRARGRGDTRLQGQFLSQYQAEQAEADRHNNRSQKLEEELERARQREAEYERERQTRSTSRPAGEIVPNKARSRSRHRGTSTAPSTPSAVGPQRSQNRYESWTKDDERDYLQSQWSEHQKGSRESSLEPQRQESVDVEVPPPLTTTPRPLPEPNVTPKPKPKPKPQSTQSPNPISSSSRPLPDPKKYAAPASASSQNRTDRFLATNTPPSQTKPHQTYSRELGATEERDGEDHRRVQSQAQTKAAGWASKSLLEREMEMERQRQQEWEDAQKETAKAVRSEGGVDGIGGGIGGRWDVGQWSGYTGGDSQNRGAQGIGSGRRQIVGPRPLPGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTT9</accession>
    <name>A0A7D5UTT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">BUB3-interacting and GLEBS motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g029040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541263.1">
        <property type="nucleotide sequence ID" value="XM_014685777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTT9"/>
    <dbReference type="GeneID" id="26245898"/>
    <dbReference type="KEGG" id="mbrn:26245898"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32997" checksum="1B2606338FDDF9E6" modified="2021-02-10" version="1">MGKKKRGHPDIEEVLVRPWCYYCERDFEDLKLLISHQKAKHFKCDRCGRRLNTAGGLSVHLNQVHKETLSQVENALPNRQGLEVEIFGMEGIPQDALEQHRSRIIQNFYQAQEDRRIATGNPASGQAMPRKKVRVEASEDLLKRLAEFRAQKKAGTLPPAAEERTNTPPTEQGNQQQTAAQPTYPGQQAYAYPADSLPARPPSHALGGTVLPQRPPQAGYWQPQGGAAGGVGDDVDQLIRMAEAGVKPQQAQEADDAGDRKAKKEKKGRMIYDDVEFSPEERMAALPRYAFVPQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTU5</accession>
    <name>A0A7D5UTU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543152.1">
        <property type="nucleotide sequence ID" value="XM_014687666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTU5"/>
    <dbReference type="GeneID" id="26243953"/>
    <dbReference type="KEGG" id="mbrn:26243953"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028816771" evidence="1">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="145" mass="14881" checksum="D6FC27C313C9232B" modified="2021-02-10" version="1">MKAAVVLSFVAAAVAGAIEPREGHCGGDNCARQVTGTRDGLTAITSRKNDCSNFMKTTVVPEATTVTVTITVDADEPASVTKRDIEYRAATEAPTAVPAYASSCNNPGKYSSACSCWGITAVTVTAPVPTKTATVTSTADSCEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU81</accession>
    <name>A0A7D5UU81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Crossover junction endonuclease eme1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">eme1</name>
        <name evidence="16" type="ORF">G6M90_00g030310</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539743.1">
        <property type="nucleotide sequence ID" value="XM_014684257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU81"/>
    <dbReference type="GeneID" id="26247500"/>
    <dbReference type="KEGG" id="mbrn:26247500"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
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        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="350"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI66970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="653" mass="72054" checksum="BD1E40D04526606D" modified="2021-02-10" version="1">MASDVIDLISSSPVRTTTSRPSACVQQPAKRRDDIDDFDDLDDDVFDVLDDRQAKRKRTTGPGDAQTNCDKLTTAISSKPPLPLKEQTSRYQNPTVWDPIEFTSSLEPVSPAKEQIDKGLPSQTSVAKKAIGNSTCEDAISCFSSDPFASSPHPLPGRPLASKRAVSLDPFCSSPPPSLTTSRSRNTATEYGKGRDGLRWQAGISRQSAIEVHEDVDTSLFADPQLPRWANEPVVLEDLITIDDSDSLSDDANDALPAISDMDVSKRRARSPLRRSQSDLTWSKSRTCYSATSTKRVKPQKTAHEREVEKTKKRLEREEAKAAKAAEKQRAAALVEVNKLRTDKKVSTPEMIVDLPSGLSSELRIQVQEMLQGLGVDHATWDCPKHSIIKWRRKVTSKYNDDIGLWEPVPAKIVDEEIAMIIVTAEEVVAMALGDLLASHVADIKTHHGSMKFVYLVQGMTPWLRQNRNNRNRHFASGVRSTGAAASSSSRTNNAEYISEDTVEDAMLALQVEHGMLIHHTAVAIDTARWVINFTQHVSTIPYRMQRDQATSVAGFCMESGQVRTGDSAHDTYVRTLQQVVRVTAPIAYGIAAEFDSITKLVQGLERGGPERLDSVRKSANKDGAVSDRTLGQAISRRMYKVFTGKDEDSTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU82</accession>
    <name>A0A7D5UU82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Siderophore biosynthesis enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g036930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130196.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90967629"/>
    <dbReference type="KEGG" id="mbrn:90967629"/>
    <dbReference type="OrthoDB" id="3942074at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028929607" description="Siderophore biosynthesis enzyme" evidence="2">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="19755" checksum="6D21CA4CA2730514" modified="2021-02-10" version="1">MGPNSFALGALCLASLAFARTDLVGCTYFDTVSAYPGGQPFATRIWYVPGSGELCEFLDCGGGRAPPKTTVPGCAAYEGTETYSPSFINPKTLGHAPATVSPAKTTSSSAAGTPTAASSPGITGTEVPATTEASAWSETGSKTAMVTSTPSGSGSRGAAMTNTTKPTTISSTGAAAGLPTAGPVVLGSWMAAGVVAGLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUY8</accession>
    <name>A0A7D5UUY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Grainyhead-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">grhl2</name>
        <name evidence="8" type="ORF">G6M90_00g043120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986383.1">
        <property type="nucleotide sequence ID" value="XM_066130317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUY8"/>
    <dbReference type="GeneID" id="26240209"/>
    <dbReference type="KEGG" id="mbrn:26240209"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="245"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="784" mass="85947" checksum="416231D2EA21617A" modified="2021-02-10" version="1">MANKGPEPDMKTSSQKPGDDLLANFRQQFPEVAAVTSEASAPTIAQAASAVDHPIINLPPQDQRNPNVETDVFRDQDPTPRASHEPWRFTPSLLDPNSYAFNAFASTQPGYYVPTPGGNNPLLHSQAGDLHTPTIAAGGLSTPLSLPNSGDALHAGATAMDLSGFQALPPHQFHHFNPFIHGAAFATTSFVHQDTGYETMDQDGVVLEAAPPEHRVPSMVPAVLQQPQAVGHMMQMGHALPPNAEKFRFHCTLNAPTAMIKQADEIPITYLNKGQAYSLSVVDTSGTFPIPPGTKYRTFVRVSFEDEEQRQKSSVCWGLWKEGRGTNEAHHRGGKLQAVEYVEAGQPAENDDKRARIEVESASFDGFCVTWTPGASGSHDVNLAVRFNFLSTDFSHSKGVKGIPVRLCAKTSLVPADGSLQDAESSSEVCFCKVKLFRDHGAERKLSNDIAHVKKSIDKLKQQLAQIESGMKDMGKRKRISSATKGSDPQRPGKVQKHKRTWSMSSTSSNAGCGGSRMTLEEDLQIKLQTLQDMFTSTRPVSILYLRGEDLDDPDLHPVSLPGDMSPPNKLEVSREGPNWQARSTKSSVAGSMVSPSPSSLSLVSQASGMWQNIDNTTASGKAFEQISRIPRMDDAGTLSGWIEALGVDPSYRPPAEQAEKPVACFYVQYRDKSEQGKPTYYRAIYLSKRTVEEFNGRISSKWGVEPAKVLRSLRVIQGGLEVEMDDDVIRELREGQDMRLEIEEVIEQSSQTKREWEMLLDETGADGDDVAPFAKGFVLRLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVK1</accession>
    <name>A0A7D5UVK1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DSBA-like thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g038580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547215.1">
        <property type="nucleotide sequence ID" value="XM_014691729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVK1"/>
    <dbReference type="GeneID" id="26239778"/>
    <dbReference type="KEGG" id="mbrn:26239778"/>
    <dbReference type="OrthoDB" id="4935513at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="37"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="28889" checksum="B4ECE68EBA33B9A5" modified="2021-02-10" version="1">MAVSQLDRLDLPQTATALGKPVSMPSPNRAERLLVPIELFSDILCPWCWIEKRSLEAAMKKFESKHPQVEFEVVWRSFCLNPLFKTKCGKIALYDEMAGGPGKFQPHLDRVSAVGAHYGLKFSVTGDTGPTRASQILIANILRRRGPAAQARVVEALFRSHFLDGKDISDEDVLVSLGSETAGLPADVVRSDLRDDDNGRFVDDEAEAAVEEKGVEAVPCVTVLGKYKVGGYQEQEVFEKLFERIWAENARVLSKPWDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW92</accession>
    <name>A0A7D5UW92_9HYPO</name>
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        <submittedName>
            <fullName evidence="5">Tip elongation aberrant protein Tea4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tea4</name>
        <name evidence="5" type="ORF">G6M90_00g041800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547522.2">
        <property type="nucleotide sequence ID" value="XM_014692036.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW92"/>
    <dbReference type="GeneID" id="26240085"/>
    <dbReference type="KEGG" id="mbrn:26240085"/>
    <dbReference type="OrthoDB" id="196165at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000035">
        <property type="entry name" value="SH3 domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="510"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="681" mass="75371" checksum="49CDD14B0478657D" modified="2021-02-10" version="1">METSGDRHVYSIHSPSSHAGLLEPCSEDECLLETEDIDFEFVYALHTFVATVEGQANATKGDTMVLLDDSNSYWWLVRVVKDSSIGYLPAEHIETPTERLARLNKHRNIDLSATMLGDQAQSKKSSFKSMRRRRKTVTFADPTYVDYSDFDYSTDDEDIEELFGSQTNTQHQKEQQQDKQNGAEDAITDETAKVEPLKTRPSNEEKVATESVKDVRTDDDDTRSSEESIDEKPEGPSRSRNGTVRNTDSFFKDESVETKKITLTPNLLRDDNTPRQSSDSTTKDARSGSSLDKMDRELVSDKEKKKMKDKDKKDKDKKPGGLRGFFSRKDKKKTSEDDDESFGKRSMDIMSESRDSEDRSLEEPLSPDRAASQRQPSKLQKSAPSNKAAGVVQKSVELSSYLAEGRTNDVSSVPPASMRLVDPDTNEAQDEPVNQTQTQDASRERSASSAGQKEEKSVMSKLVPSRSAGDPKPQKTVKAKMRMELDTSDSSELEEAPTVRPNAASGALAEPEHQNQTDQPTRSRVDNSQTPTTAGAARAQQSPIDQTLERNGSSSPANASNPPALMVDTSSPEGDLPEASPSPEPEETVDDVARESSSASSGKEGAWDDTKLRAFFDESDHIRDLLAVVYDKTNVEPAGIDHPVVGGLFREQNAKLAEITTQLDNMLGDWLARKQRLRGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWD9</accession>
    <name>A0A7D5UWD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g062740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986677.1">
        <property type="nucleotide sequence ID" value="XM_066130751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWD9"/>
    <dbReference type="GeneID" id="90967853"/>
    <dbReference type="KEGG" id="mbrn:90967853"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="15087" checksum="C203AC335829D6A6" modified="2021-02-10" version="1">MDANSTPFTLDITVQYLRTVNKVNKYDWPLYATGRAPPPSGYLLHAMDTGRTELDLYKEVRKVSDPRKSKSLVVCLTIANAPSIQALGRTVLSVRLMDRNYLPRGEAQWTSIDVVFGSRRLFGPFTKITISISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWJ4</accession>
    <name>A0A7D5UWJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g055270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986657.1">
        <property type="nucleotide sequence ID" value="XM_066130599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWJ4"/>
    <dbReference type="GeneID" id="90967794"/>
    <dbReference type="KEGG" id="mbrn:90967794"/>
    <dbReference type="OrthoDB" id="10327549at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="127" mass="13994" checksum="A3199A40CA102F34" modified="2021-02-10" version="1">MASQPLPTLDLTDLTVRDLTEDCLSTFPCCTQLGCHDNRVLMDNMLESLHLWAQSTAETAAASGSLEKALESRPDYLQNIKSNLFMISVELNSYAMNATNYQAANESILTIGRFIESLDMMARAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXH7</accession>
    <name>A0A7D5UXH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylinositol/phosphatidylcholine transfer protein SFH11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SFH11</name>
        <name evidence="2" type="ORF">G6M90_00g055180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540889.1">
        <property type="nucleotide sequence ID" value="XM_014685403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXH7"/>
    <dbReference type="GeneID" id="26246195"/>
    <dbReference type="KEGG" id="mbrn:26246195"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF20">
        <property type="entry name" value="CRAL_TRIO DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G00680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="96"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="346" mass="38190" checksum="BDD7DC10E284748F" modified="2021-02-10" version="1">METSLLQAASGTLTDDERTCLDTFSKLCYQEKLLQRPEGLQHGDLIDGLTDEHTLLRFLRGKSFDVDRAYEQLKEALAIRQSAGVIATYDTIDLGDFEEKRKLYPHWSGRRDKSGKPICIFDSRHLDDVVIQRYNEDRSVSRGAAAVSSAMEHAIVFHDYLTRFVFPVCSAMRDRKQPGTAISSAVYIADVSGMTLKQAWNLRMYIQDFGVLLSTCFPEVIDRIYAVNAPSYFGAIWSFVRKLIDPRTASKVEILYPGQVPAALAAVVDADDLPTQYGGRREVQYGAPPVMDEAMLQSLTSSSLGSAGQWPQGPIKLRSNGDGQVALIAVGSEGGDGRRDLIGLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXI0</accession>
    <name>A0A7D5UXI0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g059060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544479.1">
        <property type="nucleotide sequence ID" value="XM_014688993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXI0"/>
    <dbReference type="GeneID" id="26242891"/>
    <dbReference type="KEGG" id="mbrn:26242891"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="125"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="284" mass="30599" checksum="FE604BE20B176998" modified="2021-02-10" version="1">MPSIGPQLPTSPPKRKRSSSPPKHTSLPPAKQARASNNADEIDLSDSDSDLSFGPPAPPSTTTAPTKPCPPAKPDSTSLPADSDSSDSDSYGPSLPTATSKRPTIGPSLPATDPAPQRDSWMLAPPSSSGYTERDPTRMRNRKFTSKPATTSSGPSSIWTETPEEKLKRQRDALLGRTAEASADGGSASQRTKHQEERDRKIAATIDAHRGKSLYDEHSRKRRDDGAKNGRAAHDNDDDDDPSKRAFDREKDMAVGGKIGEKARRELINKSANFGGRFQKGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXR4</accession>
    <name>A0A7D5UXR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MKL/myocardin-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g057670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986831.1">
        <property type="nucleotide sequence ID" value="XM_066130648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXR4"/>
    <dbReference type="GeneID" id="26242761"/>
    <dbReference type="KEGG" id="mbrn:26242761"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13491" checksum="9E004DDB10EB95A7" modified="2021-02-10" version="1">MSEPAAVEQQPQRVDETPISPIRPDAARKNSLENHLMHRPNRAELVEKNILPASSAAPGLLAHQKELERSMLEDKLNDKISHRPSPEALVKGGVLHEDPRTADQQYEEAIEDEYAKREGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY23</accession>
    <name>A0A7D5UY23_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar amino acid transporter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">avt3_0</name>
        <name evidence="9" type="ORF">G6M90_00g057880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544368.1">
        <property type="nucleotide sequence ID" value="XM_014688882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY23"/>
    <dbReference type="GeneID" id="26242780"/>
    <dbReference type="KEGG" id="mbrn:26242780"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="209"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="65451" checksum="223CF142EF2FA482" modified="2021-02-10" version="1">MDDHDATPNSLRHGAILDRYLPEGYSADPEVSLSSQPTVESIAEHGRSVEQVLGPSTTTVLPGVGIAESSSTNPDDLSSETLESSLKLQGGDIHRDMFKIKAQANSLRRAATFSHQPSPRLGPADEHAHHGRHRRRFSGTVIITKNFVDFLDLYGSFAGEDLEDEDTSEDESAIDDHDVDEPNERRPLIDRPFTRRRRSSRRLAREGDASTVKTFFTLLKAFIGTGIMFLPKAFRNGGILFSSLTLVAVSLINCLCFRLLLDCRQRYGGGYGELGASIVGPKFRGLILGSIALSQLGFVCTGLIFTAENLYSFLDAVTRGQRNVDVGVPSLIALQLLPLVPLVLIRKISKLGPAALLADIFILVGLVYIWQFDIRALATHGMAPSVQLFNPSAFTLTIGSAIFTFEGIGLILPIQSSMKKPEQFSGLLYFVMLLITVFFTSVGALCYATFGEETKIQIISNFPQDSVVVNAVQLLYSLAVLAGEPVQLFPAVRIIETSLFGERATGKKSLAIKWQKNAARTLVMGLCVGISIVGASDLDKFVALIGSFACVPLVYIYPAYLHYKGIAESSWAKALDMAIMIVGLVAMLYTTSVTSAQWIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY91</accession>
    <name>A0A7D5UY91_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g060810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986875.1">
        <property type="nucleotide sequence ID" value="XM_066130707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY91"/>
    <dbReference type="GeneID" id="90967832"/>
    <dbReference type="KEGG" id="mbrn:90967832"/>
    <dbReference type="OrthoDB" id="4879292at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="24932" checksum="B4E6DAD794AE396E" modified="2021-02-10" version="1">MNDPGTTGYSVAWNPARRALRIARHMAVDDVSCYANMGDDATAWLHIPISRGELLAELWRRDCYLTSSNARSSVHVFPIIKLQRQRDYLFIDDSAGIRELALTLGPEEANETRNLRKPAPESCYPAITSVESYLYTFAPLENLDLIKTCSFAALLRACFSSTTTAREQVWGRSDWLGLEQQVPREATIGFAMSRTADQCPYVGSVLVCVAPLARNLLPAKSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYD1</accession>
    <name>A0A7D5UYD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g053400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986904.1">
        <property type="nucleotide sequence ID" value="XM_066130561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYD1"/>
    <dbReference type="GeneID" id="90967781"/>
    <dbReference type="KEGG" id="mbrn:90967781"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="93" mass="9807" checksum="F460A76589EA214E" modified="2021-02-10" version="1">MSVSGRQGARIRSLIISAERDGSSGEETCIKDMDLRQEAEPVGPNNDVTSATKAMAACDTKRDVGIDRVNGANEVEKGKNKARVGFGGLVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYE5</accession>
    <name>A0A7D5UYE5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g053170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540443.1">
        <property type="nucleotide sequence ID" value="XM_014684957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYE5"/>
    <dbReference type="GeneID" id="26246805"/>
    <dbReference type="KEGG" id="mbrn:26246805"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46412" checksum="61223212BB6E0E28" modified="2021-02-10" version="1">MALGSIAKPLETRLEPLESASRSVSGDDKKSRQQAELYYQYALRRIGMIGGSLTACQCHFLNGIYLLYTLRPVQAWQAFFHASSLYTVYLKSRAAAQQIGPGHYHDDALIGDESCSGEKLRCCLEQRLYWSCIKSESEICTEVDLPRSELGKMEYPYLFPSPPTPKSVDGLHDTHDMGAVGMLAPTALLSVDDAAEKQDFKTLHEHSWFSYLSNIALLRISSRVDDEFYTNPPSLWASMNLLDMANTAWDLEKQLLQWQHTLPSSISCFDEPASLSTVTELQLATWLHCTSVRLRMYRPFLYRLALQQGHDWPLADALKQFADKAVVLSLNPLHTLGLQHRHAGSWFRCRESASRVLILICARKIGLVSKMGLEQQVQDMLGICLAHLRFWEEEAEDIRRVRQVLEPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYF7</accession>
    <name>A0A7D5UYF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g053310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540457.1">
        <property type="nucleotide sequence ID" value="XM_014684971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYF7"/>
    <dbReference type="GeneID" id="26246819"/>
    <dbReference type="KEGG" id="mbrn:26246819"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF103">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61656" checksum="41303A13A64358FE" modified="2021-02-10" version="1">MSSSEKHIVETSALQAAPYRDNSTPEKSAANPTSSSGLRQRVHLVTKQDIDDTTLFYNRHKDDVEPIKPDEERRLNRKNFWFLLMQTWWVAFLIHLDKSTLSQASTMGIFRDVKMSKSEYNDLFVLFYAGYLIALWPGAALAQRVGHKQFITGSLLLWALLLGMHPLVKTGKQMMGLRFILGMTESQIVPSTTVLHQAFFPPKKSPWVQLLWWASGSFANVLLTMVAYKLIIDDQVGGLAGGISSWKWLHIICVVLTFLVAVPLIIFLPNNPSEAKWLTTREKVQTIRIIRETHSGISNKSFKWYQVRECFTDVKSWLFIIHMFFNELPNNTSQQLPLILVGFGFTPAQSALFNIAKPLWGSFLILVSAAMLYGTELGVGYTCAISYIPCFVGGIIMVSAPWSNKIALVVGTQISTFKPSYLLGLSWAGTTTIGYTKKLCLMSTCIVAASVANMISPEFWQEKYKPRYLLPWAFMTAFWLISPIMCLIIRWYLVNQNKQRAARLEETRGSDSEVEGLDTGSEILQLNDQDLDLTDGQNLRFVYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYQ6</accession>
    <name>A0A7D5UYQ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Regulator of V-ATPase in vacuolar membrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RAV1</name>
        <name evidence="10" type="ORF">G6M90_00g072890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986952.1">
        <property type="nucleotide sequence ID" value="XM_066130974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26241806"/>
    <dbReference type="KEGG" id="mbrn:26241806"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1311"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1370"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1528"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1554"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1644"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1671"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1703"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1734"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1771"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="9">
        <location>
            <begin position="584"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1473"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1487"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1497"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1800" mass="200435" checksum="F01588485E0E8CDA" modified="2021-02-10" version="1">MGVIKIAFTILDGVYRILQTVYDDDNEQQLDAIAIDELSGKIATCTAEQVRIYRPLILQDDNRKWAQQSCFDIPQAISKATCALSWGGSEELLVASNSLYLFTTASFPVNIWQKVLPNPAKSAIISHDSAYIASIGQHDCLTKVWRRLVYGADEVRFDVTYLRHPDIVVSIRWRRPHRPDQSADNVLYTICLDNSIRVWIPTEATEGRHWQLLGRVDMNESAIEMPVRSNPPLIFIVDGSELTAAVEKAVKDRRADDRSTDDAALDPLVTTVVNKNPEMCVSIDKLGNMSVWALENVGNNKPEQFKVFSVAKFKLPHFEPMDEFLNGQEGGGHTEVQSYCDRSSGRLHIVLHSFDGKIGIFSGNVADLLDPKKNDRRLNLQTVWTGHSAPVKKIVRNFSGHAVVSRTTSGECILWNHSALDGEREDQTLIRRSVIPENGNIHRICVLRKGRFVVLLYHKAIVVWDCRNGSASRLAECSFETQETPLCLIVLPRPRNTQYMLAYIATITSSGHGIAWEIKLPQYLSNDTTIGNVVGLSEFCRFELATADELKYVLPVDPAGAAPSMSGFLDIFARDVAISYTRSGRVNFWAARVNLASRAVDWLSTSCTETGLLDPALASGSMLKKAALVNLTRSQLTIWDIGDSRLEYDMDYEAHHSIQDLDWTSTPDAQAILAVGFQHRVILLSQMRFDYLNKGPAWAPIHEIDIRDLTAHPIGDSTWLADGHLVVGAGNQLFVYDRRIDTGDSSITPISHLNRDDRRDLFEVVQRFNGPIPIFHPQFLSQCILSGKGPVVRRILLALYKTLRYLIPGDTMDDYLGLPLSEFYIENTSPISSWGKTKESSFFDGNDCGEDDMFSAEMAAYINDKLTKIRIPQLTGHEQIQLADIIECVAVVESHRRSMDENGARFMLFFRQHALRKGRINDMHLSWREINWAFHSGSQDMLLDFVSRQNHGAMLWEQARECGVFMWLSDLTTLRDHFEGLARNEYTKSELKDPVNCSLFYLALRKKTVLQGLWRVASWNKEQVATQKLLANNFDDPKSRRTALKNAYALLSKRRFHYAAAFFLLADRLEDAVEVCLRQIKDLQLAIAICRVYEGDSGPVLRKLIRDEVLPLAAQEGNHWLASWGFWMLGRKDMAVRALIMPVFALLETPCSPDIKSRLFLTDDPALVVLYSQLRQRTLQTLQGASKITPKVEWEFVLHSAKLYDRMGCDLLGLDLDWSISFRRRQQVIIRERLKFPSGFSTAVLISVLHGKLSQSSKPENLDSAARGGFASLVPRTAIQDLAVPNTITDSGAENDIETQADPPPDCASNMGLLLICFLISGFFTILTYFLPIMRNLPIFGTVAANTWLWTLNPSLAYVGQGVIMGTETTLHMTLGAIVGWGILSPLAKFKGWAPGPVDDWEHGSKGWIVWVSLAIMLVDAVVSLGYVGCRSIPSFPGIRFIENFSKRLRKAREHIFGDSPLQYTLLQNQDEDFQPHTPDTANDTMEASRDGNDDVDRNDDGDDDGDDDDDDDDDDDAPADQRIGGRLVVIGLITSIILCIGTTHFVFGDLVPLYATVLAVFIALLLSIMGVRALGETDLNPVSGISKLAQLFFALIIPQSNKSSVLINLVAGAVSEAGALQAGDLMQDLKTGHLLGAAPNAQFWGQVIGATAGAILSAFIYRIYTSVYAIPGDLFQVPTAYVWIFTARLVTGQGLPYMAKEWALGAGIVFAVTTLIRTAGVDKWWRPYVPGGIAVAVGIYNVPSFTLARAVGGIICWYWTRILGRSNAQLIILASGFILGEGFLSIANLILQGLKVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYT9</accession>
    <name>A0A7D5UYT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General vesicular transport factor p115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Uso1</name>
        <name evidence="8" type="ORF">G6M90_00g072910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545771.1">
        <property type="nucleotide sequence ID" value="XM_014690285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYT9"/>
    <dbReference type="GeneID" id="26241804"/>
    <dbReference type="KEGG" id="mbrn:26241804"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="6">
        <location>
            <begin position="342"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="7">
        <location>
            <begin position="824"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="910"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="936" mass="103935" checksum="A1505C1E03A82D66" modified="2021-02-10" version="1">MFSISTTPAKQSVSETITVYSGRLNSATLLEDRRAAILGLRSFAKDFPASVASGALRCLIGSLAKDGDDVDTVKIVLETLLMLFSPNESSPEASDEVVLWLADEFTQRQENITLLLDFVESNDFYSRLYSLQLLAAILSARTERTEECIFTAPLGISRLVATLDDQREAVRNECVSLLIALTPTSTEIQKLVAFENAFERIFAIVAADGSLTQGGRTVEDCLILLANLLRRNASNQSLFRESGCISKLASLLEGLLQAQLSNADIAVWAQAQRNRNVYAFLAVLRLFLLSGSAGVSQNQQAFWKQGLVYNILQLAFSREEGQVTIKAEALNTCGDMIRDAKPLQETFAQLMVPAPLLVDTGEDASSTLAAKTYVIDGLLDLTLNSFDQSAFDLRFSACECLKAYFSNHSEVRLHFLSRAIDGYMAAAEESANILTVLLRPDAAALARDPYRQWFASVIAFHLLHDNPTAKARLLQVTEGDSSKDEEVVTSIQTIAAHLITSITRNDDARISVGYLMLLIGWTFEDLDAVNDFLAEGSNVQSLIQAISHAVPAKGVLIQGLCAFLLGVVYEFSTKDSPLSRTSFHSILSKRLDREQFLERLTRLRSHPLMRDFEVTSQKHHPSLGNSLPDIFFDSVFVDFFKDNYSRIGRSIDRAPELEISVMTNGVQKGISRELVDSLRSQVGDKDRALQESKTKIISLEEALNSREAEHRQSSEAAAIELSKLKASFDNAESGHEEQLRRLAQKHSAKLADQERHIASFQAQLAAREAKYQNELLQAQQSAHSEVERVRLRADAEVADLKASMNRLEVDIIKANKSKALELQKLQEKNSRLVAIEVDQKTQAENRNSDLEGQLQKARTTIEELQRKVERVEKTLSEESGAKRTAQTELDDLLIVFGDLEEKVARYKTRLRKLGEDVSEGEDDEEDGPDDTDGEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZM2</accession>
    <name>A0A7D5UZM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987176.1">
        <property type="nucleotide sequence ID" value="XM_066131145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZM2"/>
    <dbReference type="GeneID" id="90968034"/>
    <dbReference type="KEGG" id="mbrn:90968034"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="80" mass="8506" checksum="7933929FA772FC41" modified="2021-02-10" version="1">MAESSSPVQTWKELRDQIKAADRAASAASSGDSKAQERPFLVAEGAGNPYPATPGMRINGGWDGPITEPHRVREREVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0I1</accession>
    <name>A0A7D5V0I1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987195.1">
        <property type="nucleotide sequence ID" value="XM_066130899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0I1"/>
    <dbReference type="GeneID" id="90967909"/>
    <dbReference type="KEGG" id="mbrn:90967909"/>
    <dbReference type="OrthoDB" id="6368724at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="23624" checksum="70DC21E85E5F2FB0" modified="2021-02-10" version="1">MSAAIPRGWQTPAAVLSGWQAYSALSPVDGKPSLLSPVDGRLPLLSSVDDKLIRAVPSGWQANSALSPVDGKPSLLSPVDGRLPLLSSVDDKLIRAVPSGWQANSALSPVDGKPSLLSPVDGRLPLLSSVDDKLNSVPSPVDGRLPLLSSVDDKLNSVPSPVDGRPPLLSSVDDKLILCCPQWMADPRCCPQWMTSLFSAVPSGWQAFSAIPRRWQTPPAVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0L9</accession>
    <name>A0A7D5V0L9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sexual differentiation process protein isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">isp4_7</name>
        <name evidence="10" type="ORF">G6M90_00g090900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987284.1">
        <property type="nucleotide sequence ID" value="XM_066131387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0L9"/>
    <dbReference type="GeneID" id="26245608"/>
    <dbReference type="KEGG" id="mbrn:26245608"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="679"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="846" mass="95388" checksum="8F3B17F8EE91A41E" modified="2021-02-10" version="1">MPLSIFRKRHEVEEIMPIPEPLEGNSSGVDHLKHLAAFEKAHKLDPNLPMDELNDVDAALATGNAEKGLEIEHALMEDNSPYPEVCIFLFHLPLGPLESYERPYDASMAPEMNEAWLASLSSFIFCAWELGLVRAVVRNYDVDVPANTIRAWVIGLLLCTVGSGVNMLFSLRNPTVYITTYVVQLIAYPIGRGWDMVFPDKVWNVCGVKFNLRPGKFNFKEHVVIVAMSNAAYGGGALYATDVLLTQKVFYKQEFGVAFQLLFGITTLCTGYGMAGLARRFLVWPAAMIWPADLVNCALFYTLHDHSRSDPSKTNGWTIGRYKLFLIVGCAAFTWYWFPGWIFRGLSYFAIACWIAPNSVVVNKLFGNNHGYGLIPITFDWTVATGFIGSPLIPPFYAIVNVLGGIIFFFVIVSMGIHFSGTWYADYMPVQSSTSYDNTGAPYNVSRILDANFSFNETAYKEYSPLYLSTQFAMAYGMNFAAMSAVLIHVALYHGKEIWRQFRMARHQEDDVHMRLMKKYRDAEDWWYAALFIIMVGVSFGVVTGWPTGFPAWAFVVCLLLPIIWLIPIGLIQGISNIQIGLNVLTEFIIGYMVPGKPMAMMMFKNYGYTSMSQALYFAQDLKLGHYMKVPPRVMFSSQLVASIWSAIIQIGVMNWALAKIPDICTDNQKDSYTCPSGHVYYTASVIWGAIGPARIFSHGATYANLQWFWLVGAATPILTWIFARRWPRSFWRYVCTPVIYGGTGLLPPATVHIFLCWGVVGIMFNYFVKRRYTGWWLQYNYIVSAALDCGLIISTLLIFFTLYLTNVRAPAWWGNDGMTETLDWNSQAIAKRVAPGEFFGPAVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0N8</accession>
    <name>A0A7D5V0N8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g084250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543641.2">
        <property type="nucleotide sequence ID" value="XM_014688155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0N8"/>
    <dbReference type="GeneID" id="26243818"/>
    <dbReference type="KEGG" id="mbrn:26243818"/>
    <dbReference type="OrthoDB" id="3594971at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55693" checksum="BB4DE4513F85A65B" modified="2021-02-10" version="1">MSVLEQLQYLDAKSIFVVRSVSQLFNSIATPIAYRRVVLNELIVRPDAQTLFSKALEHISTYTKHVVVRNNLKPSGIRKILSRIMRLSSVTLCYVQDDSHGASTWPIHDVLDYDQLRTQNTKVNIENLPLGGSQSDLHASLLDPAFTRHLVSLKLARPTPPLTTKVDSLKRLLVQCSSLETLHYEDLGQGTSFTFSAGECLPPLSNLVLKSYDWTHSAEEVERHWNLSQMKSLVLVSVPVLNFLNSISPPDLCNLTRLQVHDSLAHASDGREEATRRLDLLVRKHIRALEVLDITCHTNLFHIDSILQHGGSLRQVHFRDHIGFTDDDDECPTLRAEDVTRLGQGLPFVHTLELDMDVALCYPPEFLRGIASFPMLQTLILHVQTLLRATEKDDPARDRDYESAMQMFSCLVRLREKSNPDLAWKSITINVGGWRRVMLRRMGPEWRRKNARGIFAERCFVLEKDENGRYRVAEQECHDGSQYISTSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1L2</accession>
    <name>A0A7D5V1L2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">taf8</name>
        <name evidence="10" type="ORF">G6M90_00g070270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540650.1">
        <property type="nucleotide sequence ID" value="XM_014685164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1L2"/>
    <dbReference type="GeneID" id="26246523"/>
    <dbReference type="KEGG" id="mbrn:26246523"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="9">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="316" mass="35585" checksum="20AD810F929B362A" modified="2021-02-10" version="1">MSSKRSLSPSDSDGSSKRRRLSGPHPDCIQDDIVSVDMLEARDDNEVMAVKSFAPTHHANARTGIQRSIALVLKHDGFSSATPEAMESFTALVETYLESIIEETKRLALSSRRDHPVPMDFEAVLRRFNLPVSSLKPHLKNPLPAEAYIPRYKSVHVADDDAYTTLPLLGPELSGQPDKKSKSYIPSNFPDFPSRHTYKFTPQEDTNARDAQKTREEAARIAQQGEDALRRLVRASKMRKQKEAKNLVEKDVQGKERFRLWELTMKRFMGAENRGENTDNVDIADHSMIVNGDAVFSRKEVSRIGKRLTVLPSKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1P1</accession>
    <name>A0A7D5V1P1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">cyt-1</name>
        <name evidence="18" type="ORF">G6M90_00g101080</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546237.1">
        <property type="nucleotide sequence ID" value="XM_014690751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1P1"/>
    <dbReference type="GeneID" id="26240660"/>
    <dbReference type="KEGG" id="mbrn:26240660"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI72836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35464" checksum="5323559922F8CDA5" modified="2021-02-10" version="1">MLARSCLRSTRTLNGLRNGVNNVSKRAASTSSGAAGEASPARLNFAAIASTTVAAGSIAWYYHLYGPVAFAASPAEEGLHATQYPWVHQQWLKTFDHQALRRGFQVYREVCASCHSLSRIPYRTLVGAVLTVDEAKALAEENEYPGEPDEQGEIQMRPGKLADYIPDPYKNEEAARFANNGALPPDLSLIVKGRHGGCDYIFSLLTGYPEEPPAGAQVAPGMNFNPYFPGTGIGMARVLYDGLVEYEDDTPASTSQMAKDVVEFLNWAAEPEMDDRKKMGLKVLIVTSALWAVSVWVKRYKWAWLKSRKLAYDPPADSKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1R1</accession>
    <name>A0A7D5V1R1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g082730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543497.2">
        <property type="nucleotide sequence ID" value="XM_014688011.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1R1"/>
    <dbReference type="GeneID" id="26243674"/>
    <dbReference type="KEGG" id="mbrn:26243674"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="521" mass="58243" checksum="3E5A7477E6E1C315" modified="2021-02-10" version="1">MMSRSGQSTEKVVMPFNHDEYAAGDNKTVSDTDDMGVGTVATPPNFDHVDEKKILWKMDIRLIPMLALLYLLSFLDRGNIGNADVEGLSVDLGIQPDQYNWCLTVFFFTYAAFEVPSNLLLKKLRPSRWLPTIMVAWGLVMTLMGLVQNYHGLLIARIFLGVTEAGLFPGVAYYLTMWYCRHEIQFRQALFFSAASVAGAFSGLLAFAISKMNGTAGLEGWRWIFILEGIATVLVAFCAFFLIHDFPDTASFLTEDERAFVIHRLKYQGQTILAGGDAERQGRAQVEQAEEFEWKYVWQAFKDWQIWVNILVYWGIVCPLYGISLFLPTIIKSLNYSKTEAQLMTVPIYITAAILAVIVAFCSDRVGKRSPFVIGFMCMMLVGFTMCLASSNPKVVYGGVFVAACAIYPAFPGIIAWLSNNLSGSYKRSAGMALQIGIGNLGGAMASNFYRKKDKPRYFLGHGLEIGFIVLGIAAAFILVLGYRRLNRKRERQLAEGQDKNYTAAELSALGDKAITFRYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1T7</accession>
    <name>A0A7D5V1T7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SDH2</name>
        <name evidence="21" type="ORF">G6M90_00g085790</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541138.1">
        <property type="nucleotide sequence ID" value="XM_014685652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1T7"/>
    <dbReference type="GeneID" id="26246127"/>
    <dbReference type="KEGG" id="mbrn:26246127"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="21" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI71893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="31466" checksum="306233A9FF336B6E" modified="2021-02-10" version="1">MAALRSTSSRILGSSIRTAMRPGAVFTRSMASVSEAPHEKAPNMKTFQIYRWNPDTPTEKPRMQSYTIDLNKTGPMILDALVRIKNELDPTLTFRRSCREGICGSCAMNINGQNTLACLCRIPAESSSDVKLYPLPHTYVVKDLVPDLTYFYKQYKSIKPYLQRDTPAPDGKEYRQSKEDRKKLDGLYECILCACCSTSCPSYWWNSEEYLGPAILLQSYRWLADSRDERSAERRANLENNMSLYRCHTILNCTRACPKGLNPGKAIAEIKKQMAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V216</accession>
    <name>A0A7D5V216_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g104940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73116.1"/>
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            <end position="109"/>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <name>A0A7D5V2L3_9HYPO</name>
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        </submittedName>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
            <begin position="708"/>
            <end position="739"/>
        </location>
    </feature>
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        </location>
    </feature>
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    <sequence length="739" mass="80037" checksum="4FBBC3682C54A9E4" modified="2021-02-10" version="1">MPKRPDLLDLRADSHSSAMSSSSRPLRSPRMHVAGEVPPELSPLDAFALQSRLLAKQLQESNRDGNRMSRLPPLTVESPLIVQGRSEYFRSMSAESVSDPESPEPSSGFGFKTEIEDAFTNEERPKSMHPRMSQIPPTPDVDVPALPGSFPDILRGRQMDPVQQRGDVFGARQERSPSPIQSDSQSQYEKHSEPSPACKDNSLQSTSSRNAPVSTGSPERMKQGRFDELGLVPPPSLFPRRSSSILSSPVLEDDENSSNMGSSFHSLPRKLSSGSAALASSVHSPALTSSFKRSPSAASDSSALPRPSFNFSRPLSRAGTPGFDVPTRQASSDSQPSFILADDTAHTPVSMHSEAFMDQQTDDAKGAATSYIYSKFSLPRGKALQRQEPNEITSEQPMASSSNAQRYPNGAPPSPPTRPSSSSARTVPDDAISTVSGTTRPSMDVGKVSMESSRLAAAGTSSFPPRPSVDAIRKSEDGPRGRAFTSALHEQSRGRTPASTNTSDSASTIRPPPTSRSLAPTASEMSAEEHLAKGIECHENGSLNESTYHLRLAARQNLPTAMLLYALACRHGWGMRANQREGVEWLRKAAEHASIEIADDEDQVKEGRAAPAAVVERRARKAQFALSIYELGVSHMNGWGIEQDKSLALRCFEIAGTWGDVDALAEAGFCYAQGIGCKKNLKKSAKFYRMAEAKGMSMVGNSWIHKAKYNDDDEPSPSKDGKKTRSKSRTRTMFGLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3R2</accession>
    <name>A0A7D5V3R2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pmc1_4</name>
        <name evidence="18" type="ORF">G6M90_00g104260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987716.1">
        <property type="nucleotide sequence ID" value="XM_066131639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245672"/>
    <dbReference type="KEGG" id="mbrn:26245672"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
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            <begin position="946"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1123"/>
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    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
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            <dbReference type="ARBA" id="ARBA00004127"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361146"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="1294" mass="140166" checksum="894C0902D0B060F8" modified="2021-02-10" version="1">MSQILKRPLAPAIRVDVSAIQHNHGDNPSALQSRSNATSNTLDVPTPTPTSSPRSSSKPTISDGDSSNRRTGDNLSPLHDINKSSASVLWPDPGEEALFNIENNPFAFCPGQLAKLINPKSLAAFVALGGLPGLEKGLQSHRQGGLSVDERHVSSPITFDQATSTLPSHGSPTHSQHDPNPPPVLPKDGPDAAFADRKRVFGENRLPERKSKSFLQLAWIALQDRVLILLCIAAVISLALGLYQTFGQTEHQGAKVEWVEGVAIIVAIAIVVVAGALNDWQKERQFRKLNVKKEDRLVKVIRSGRPMTISVHDVLVGDVMLLEPGDVVPVDGVFIDGHSLSCDESPATGESDLVKKVPAEDVSQALREEAPDTKKLDPFVISGSKVLDGVGSFLITSVGPNSSHGRTMMSLQGDSGLTPLQSKLNVLAGYIAKLGGGAGCLLFLVLLFEFLARLPSNQESPEQKGQDFLQILITSITIIVVAVPEGLPLAVTLSLAFATKRMTRDNNLVRHLQSCETMGNATVICSDKTGTLTENAMTVVSGALGGREGLVFGHGDPVPEPAGDAPIQTKEQDKGPQVARQQQTLIPLEQLSSRLDAEFQQLLKTAVAANTTAFEREEKGKMVFVGTKTETALLDWARHCFGLGPILTERANCQLEQLFPFNSRRKCMGAVIRLPETENHKDKTTYRLFVKGAPEVVLAKCSGVMDDWTKVASRAPLLQDQKDAIRSVIVGFAAQSLRTLALAYRDLEQWPPPRPQTNDTVTGSGDITLEDVLQDMLWMGVVGIRDPVRQGVPAAVQDCRTASVSVKMVTGDNVETARAVGRECGILTTRPPEQGLVMEGQQFRQLPHDQKVTAAKDIRVLARSSPDDKRTLVKLLRDQGEIVAVTGDGTNDAPALKAADVGFAMGMTGTEVAKEASDIILMDDNFTSIVKALGWGRAINDSVKKFLQFQLTVNITAVLVTFVSAVSDGNETSVLNAVQLLWVNLIMDTFAALALATDPPAGSILRRRPEPRRASLITLTMWKMIIGQSVYQLVVCFVLWFAGPGFLGYPEAQLRTLIFNVFVFMQIFKLINSRRIDNQLNIFEGLHRNWLFMVMMSVMVAGQLVIIYVGGAAFVVVRLTGEQWAISVGLGFGSIPVGILIRLLPDAILRSCGDRMRENWPRWLRVPLKRKGNDKKAPSASPVGYNSVFAGIRDDLDFLRKVRGGRIRAFSEALGVPHAVKSSHHQRRKLHPGTKPEDRSNSVVSSKSQPVSPMFSAVGMPGIVAASVGGLLPMEPSSTSQQQDCSGGNEPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V450</accession>
    <name>A0A7D5V450_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uidA</name>
        <name evidence="8" type="ORF">G6M90_00g094760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540838.1">
        <property type="nucleotide sequence ID" value="XM_014685352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V450"/>
    <dbReference type="GeneID" id="26246451"/>
    <dbReference type="KEGG" id="mbrn:26246451"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF2">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028856819" evidence="4">
        <location>
            <begin position="20"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="7">
        <location>
            <begin position="108"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="5">
        <location>
            <begin position="233"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="6">
        <location>
            <begin position="355"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="625" mass="69560" checksum="A78190FAC4867F0B" modified="2021-02-10" version="1">MHLLQRVLWGGVSLMHVAGTGGGVQGTATPYKVQTPPLDTDWTYAVGTNPWPEHPRPQLRRDDWRSLNGLWTFGDAAASDASPDRPPTAPLPREVLVPSCVESGLSGIQSLNSTHMWFGRAFPVPDDWRGARVLLNFEAVDYEATVFVNGARAGHNVGGYFRFTVDVTEHVRWGADNELFVFVHDPTDAEVIPVGKQTRNPSHIFYRSCSGIWQTVWLERAPANHITQLDVAAGMDGEVKVTAHTSGKQQGAEVTIAVVDGEGRTVGQASGPSDAEFAFRVASPRLWSPASPTLYNLTLTLGDDRVHSYTGFRTVSAGLVDGVQRPLLNGEFVFLFGTLDQGFWPDGLYTPPSREAMVYDLRMLKRLGFNMVRKHIKVEPDLFYRACDEMGLLVIQDMPSLPADGNRPPSPAQQAEFQRQLEVLVHEHKSYPSLVVWVIYNEGWGQLRGPPYPEERLTDVVRRLDPSRLVDAVTGWHDHGFGDFSDNHHYANPQCGTPFYSILSSPYDPRRIGFQGEFGGIGHNVSIEHLWNVQQAIDTINQTYEVSADLDAYNYRAGVLFRELTEQVERYACSGGVWTQTTDVEGEVNGLYTYDRRVLRANVSQWQADIRGLYDAAHGRGGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V542</accession>
    <name>A0A7D5V542_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Increased recombination centers protein 22-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IRC22-2</name>
        <name evidence="12" type="ORF">G6M90_00g096070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546724.1">
        <property type="nucleotide sequence ID" value="XM_014691238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V542"/>
    <dbReference type="GeneID" id="26241147"/>
    <dbReference type="KEGG" id="mbrn:26241147"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028969997" evidence="11">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="270" mass="28636" checksum="2FD16B20443F69D2" modified="2021-02-10" version="1">MLFSSLLSVFALHIFGAAAADAAAPAADDSASPKTPDLAAVVKTTFPDSDILGVRLINGRPTKALVEITNKEDAPIQISVLAGVLATAKTLPEGTPAYQGIIRNLTVVQYNHAIEAGETKSFTYSFALDMQPQDVKLQIAAVIANANGDMYQVQAHDGLAAIVEAPTSFLDPQIIFLYLVLSAAFGGTLYFVYKTWIEALFPQAKRSKSSSSGPKKAKKSADADAALSGSESAAATTGSKTYDESWIPDHHINRPVAKRVKSTPKKKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5B2</accession>
    <name>A0A7D5V5B2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopenicillin N epimerase component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cefD2</name>
        <name evidence="3" type="ORF">G6M90_00g107760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544067.1">
        <property type="nucleotide sequence ID" value="XM_014688581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5B2"/>
    <dbReference type="GeneID" id="26243454"/>
    <dbReference type="KEGG" id="mbrn:26243454"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="43124" checksum="99FF03445458A275" modified="2021-02-10" version="1">MAEIGPPPLTGITVLEFAGLAPGPFAGMLLADAGASVIRIDRASDTRSLPTADALTRHKASISVDLKSPPGTTFIKELVSRGADVLIDPFRPGVLEKLGLGPSVLLALNPRLVYARLTGFRRDGRYAAMAGHDINYLAVSGALSLLGRAADTPHPPTNILADFAGGGANLFQGILLALLARQTTGRGQVVEANMVDGSAYLATFPRLGLKSGVGARGRGKNLLDGGCPYYETYETKDGKYYSVGALEPQFFRLLVEGMGLAGRGLEEKRFDFDEWPAMRALFETTFRQKTRAEWEAIFDGTDACAAPVLEYQELESDAAREGDQRPSVTLRGTPCLAIKQRPAGHSDPVTHGQGAGVPGDGYEGEPLAPGDGGQQALEKWLGWQKGREYDVHKGAYILTKGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5C3</accession>
    <name>A0A7D5V5C3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g106860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539901.1">
        <property type="nucleotide sequence ID" value="XM_014684415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5C3"/>
    <dbReference type="GeneID" id="26247340"/>
    <dbReference type="KEGG" id="mbrn:26247340"/>
    <dbReference type="OrthoDB" id="4939714at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028930832" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42530" checksum="C916ECBB8AB5027C" modified="2021-02-10" version="1">MELYKTTSFLWYYLTILLAFCQVLEAQAPAGPKKERVPLPALPTDEPLPAKDSLQIKLDRDLYAKGSMVFSSHLKFENPQTITASQMKRIAVDAYDEMRSMAKKNGIPEGDMPRVMTTLIIDNELIFASSAKGPQTPYGKESQVQADLDACRGPGDNRHKHNGRCGEVMALHEYYQSHGVTKRLEKESGARIVAIAGTRNAKGQLEKVIYPPCGHKDDWGCDRLVQQLDVLDDAKVDKDKDTPAFRYKNMINNPKPELKPVDPTSLSKEKGKEKPKPGGSNDDEFEEPPKYDESTEKEGKTRRPQQPNRNKGKTGTQDNKPSQPKEQDDGGDFEEPPKYEEPTSDDRKKGKTSQKDRNKSQTNAQKKKTGNRPRHFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5D3</accession>
    <name>A0A7D5V5D3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asp-hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ASPH</name>
        <name evidence="2" type="ORF">G6M90_00g108940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5D3"/>
    <dbReference type="GeneID" id="26243343"/>
    <dbReference type="KEGG" id="mbrn:26243343"/>
    <dbReference type="OrthoDB" id="2727348at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007951">
        <property type="entry name" value="Hemolysin, aegerolysin type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="140" mass="15788" checksum="0558B3E8A6E5E903" modified="2021-02-10" version="1">MAYKQWIGIKNRSRLRRSDIRIKDAKLESGKFYRGNKDNGIGPSEINKIVIAPQSEASVHSCGRSDADIGTEGQYTLDEWNVTHETKIYRVYWSAPWGAHSNVLSILDWDPNTSDYSVIKDDVQQDSTIGNVEVVMAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6T4</accession>
    <name>A0A7D5V6T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC multidrug transporter B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">abcB_8</name>
        <name evidence="11" type="ORF">G6M90_00g107370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987943.1">
        <property type="nucleotide sequence ID" value="XM_066131726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6T4"/>
    <dbReference type="GeneID" id="26243492"/>
    <dbReference type="KEGG" id="mbrn:26243492"/>
    <dbReference type="OrthoDB" id="4952489at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF345">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="499"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="689" mass="76826" checksum="459EF629C9EE5EC5" modified="2021-02-10" version="1">MASILAVAMVVYVGEAICISVYQHQRNRLRVMMQGALVGLVFTKTLQSQSNNHDRGKSVTLMNTDVDSLSGIGRMAHDIWAYFLELAIGMVILTSQVGWLSPVPLVIIVFCSRVSKYVAQHMHGRQKEWNAATQNRLSMITAFLGLIKTIKLLGISGSIAKYVASLRSTEIERAKSVRWIMVGYNASANFLGIFAPAITMILCGVLSQSNHSTIDAETAFTTIAVLSMVIHPANIIMTIIPRVVATFASFKRLQNYLLEAPRQDQRVVLKDKPERLLPHGSTAAAALARMLYDECDIVILDDPFSSLGGRTEDQVINNLFGPEGIFRTRRSTVFWITNATSRQRCDPRELSHKGAWALERMGFSPDASGKVMSDDFHESGQVDAEASQLDAQKKKAKELDTRLDLNRKTGNLSLYGYYFKSAGLFNAIFMIGCTATYSFFITFPHYWLKRWTEADQNVEWLYMMVYGLLALFAWVPTNGTMWSTFMLVTPRSGLFLHSKAPLSFFATSDIGVILNRFSQDIQLVDRDLPAAFQSLSNQIFELLLQVALLLAVQKLLLLTIPLCFVVICLVARVYFRTSRQVRIEELASRSAVFSQIVETRWLNLVLDLMVAAISVAIIALALFLRSTTTGAAVGVALNIILVTNTTIVRLVESWADFEVSLGAIERLKSLDEEIQKEDRPGEDNIPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRD5</accession>
    <name>A0A7D5YRD5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Urease accessory protein UreF-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g062780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542604.1">
        <property type="nucleotide sequence ID" value="XM_014687118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRD5"/>
    <dbReference type="GeneID" id="26244553"/>
    <dbReference type="KEGG" id="mbrn:26244553"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31160" checksum="40AD3E5E39F17C76" modified="2021-02-10" version="1">MDPKQETVDSQDILQEEIADLERRLAAAKTRLSTPPKGSDTPQPSLQSPLNSPTHYLLLLSDSQLPIGSFAFSSGLESYLAHNRRATFSSFLPLSLSSYAATTLPFVLAAHRDPCSLIELDDQLDAAVICTVGRRASVSQGRALLSIWERSFRATLPKSADLPVLREFAALLKDGSADGEAPPVSAHLAPLFGAICAIVGLTLHQTAYMYMVSHLKALVSAAVRASMFGPYQAQKVLAGEQAQRWIGRVIDREWETRVDEAGQSVPVMDLWIGRHEVLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRJ4</accession>
    <name>A0A7D5YRJ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g019360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985637.1">
        <property type="nucleotide sequence ID" value="XM_066129831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRJ4"/>
    <dbReference type="GeneID" id="26238049"/>
    <dbReference type="KEGG" id="mbrn:26238049"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="266" mass="28330" checksum="F0975A44BA4A3870" modified="2021-02-10" version="1">MASSHHVLLIGGHGKIAQLLTPLLLKRSWTVTSMIRTQEQAPAIEKLGSGLPGKLHVLVSSVGEVSTQERAAAILNNVKPDYVAWSAGAGGKGGPEMTFKIDRDAAVHFIRAAADIPSIKRFLLVSYGGSRRAGASWWPEGEWDEYNKKVNYGVLATYYKAKIAADEVLYETSKKSSTLVGICLRPATLTDEPAGKVELGKTAHVNGDASRATVAATADALLAADGVKNTWLDLQGGSEDLDAAVKRCIKDGVDTAEGEEIFTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRU5</accession>
    <name>A0A7D5YRU5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g034940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546889.1">
        <property type="nucleotide sequence ID" value="XM_014691403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRU5"/>
    <dbReference type="GeneID" id="26239452"/>
    <dbReference type="KEGG" id="mbrn:26239452"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="30067" checksum="FD66996A13D7CAC7" modified="2021-02-10" version="1">MKTSSAVIAAIIGFASYGSAHMQMSDPPPFLSKFNKFTEQGKQDDSMTSPLLASGSNFPCKGYHSLVGTPQGQSVATWTPGQSYKMTIAGTATHNGGSCQASLSFDSGKTWKVIHSYVGSCPLQDGAAFSFTVPSDTPAGDALFAWTWFNQLGNREMYMNCAAVTIGGGAKIRKARGDTTPFSSRPAMFTANIGNGCSTEESKDVVFPDPGSELDTKSDKPAPPAGSCGTKGSGSGSGSGSASAPAPAASGALVNNSNNNAGNPSAPPASTPSPTPVSTAAAASTPKPVGSGGSCRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRY2</accession>
    <name>A0A7D5YRY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547312.1">
        <property type="nucleotide sequence ID" value="XM_014691826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRY2"/>
    <dbReference type="GeneID" id="26239875"/>
    <dbReference type="KEGG" id="mbrn:26239875"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="167"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="38745" checksum="DABA337E34A68B2B" modified="2021-02-10" version="1">MNRPTLLTTIWRRSRHISSRRAYQPLRSVEAASASSQAHADIQAFQKKAFIPRKPYLFREDGGSPTSRLPAFSKWFNRSASSHDSHSTLPFASSLVQGFQEWPFPYELIKSQREQDAFSQFQAALMTSSEMTDQIMAGILQSAVTDEKDQSFFQLYAPLRLLIKALEFNAARDSTTTHPLHLYIAQSSLSDLPQPLQDDLPAPEIVLGAGKGDIYASSIWLGTEPTYTPLHRDPNPNLFCQLYSQKVVRLLPPTKGDELFFHVQRRIRQHGNSRIRTTDMMQGHERKVLHDAVWGNETPLEELHEVELGAGDALFIPEGWWHSVKSVGSDGGLNGSVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSZ8</accession>
    <name>A0A7D5YSZ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g045770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26246590"/>
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
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    </dbReference>
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    </dbReference>
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            <end position="673"/>
        </location>
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            <end position="29"/>
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    </feature>
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            <end position="89"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
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            <end position="100"/>
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            <end position="668"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A7D5YUD4_9HYPO</name>
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        </submittedName>
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        <lineage>
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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</entry>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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            <begin position="36"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    <sequence length="219" mass="25270" checksum="B5A87B4FD288C668" modified="2021-02-10" version="1">MMYSTSNRKGGVLLFLFSLLSSLLLFSSQSGTALGAPVSDLSSLELYPRNKHIPDKNEVVELIRDGKDFHKYAKEGHPHKDKAAFFSGQGRQTIAKIRDWATAKKQGLTTVRDIWKSDNFYQQGQYKDIDAETFRDFQKAFSKYYAQQAKGKAYLIFPHDQTPKRDGIFWSVELDEIISHGKVDVIIWLDQNKIGEKEYHQDNEERIYWKKGERKPDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
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    <protein>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545592.1">
        <property type="nucleotide sequence ID" value="XM_014690106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVV0"/>
    <dbReference type="GeneID" id="26241625"/>
    <dbReference type="KEGG" id="mbrn:26241625"/>
    <dbReference type="OrthoDB" id="4958959at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028944514" evidence="1">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="207" mass="21976" checksum="A0526003EA50FC76" modified="2021-02-10" version="1">MMLNSAIVTFALSVAVSALPQAYPNKCGDQVCPADKSKCCEVIVNGVAEIGCFAECPPVQALQRRQTYPNKCGDQVCPADKSKCCEVIVNGVAEIGCFAECPPVQALQRRQTYPNKCGDQVCPADKSKCCEVIVNGVAEIGCFAECPPVQALQRRDQPSTTTAASPSTPTFGPKCGDSFFCPVGKVCCPNALYHCADPDKVSQQCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVW8</accession>
    <name>A0A7D5YVW8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">STPK</name>
        <name evidence="5" type="ORF">G6M90_00g036850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986350.1">
        <property type="nucleotide sequence ID" value="XM_066130188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVW8"/>
    <dbReference type="GeneID" id="26239637"/>
    <dbReference type="KEGG" id="mbrn:26239637"/>
    <dbReference type="OrthoDB" id="4935649at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="407"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="650"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWM6</accession>
    <name>A0A7D5YWM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g051180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539805.2">
        <property type="nucleotide sequence ID" value="XM_014684319.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWM6"/>
    <dbReference type="GeneID" id="26247360"/>
    <dbReference type="KEGG" id="mbrn:26247360"/>
    <dbReference type="OrthoDB" id="4961484at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="208" mass="22520" checksum="6D9B26B4DC36C06C" modified="2021-02-10" version="1">MNRQGLQQQPDFEAAARALEVVVDNVKLCSNIPAVDSGAALERKMDALMEQMVLFNRKLDALDSKVTALGGRFTGLDGKFMGLDGKFTGLDGKVMALDGKVTGLDGKVTALDGKVTGLDGKVTALDKNSRARAANSIVISPLMELTPMHNVRTGEEISDCPSTLGQLEGLSMQELARLLRELGEPVPRAERERRRLVKLAFGLRTREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWZ3</accession>
    <name>A0A7D5YWZ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall mannoprotein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MP1_1</name>
        <name evidence="2" type="ORF">G6M90_00g030800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539657.1">
        <property type="nucleotide sequence ID" value="XM_014684171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWZ3"/>
    <dbReference type="GeneID" id="26247568"/>
    <dbReference type="KEGG" id="mbrn:26247568"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028852887" evidence="1">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="193" mass="20448" checksum="38B4625B8091149A" modified="2021-02-10" version="1">MKFSFTVALLCLASGVYSLVAAPPPTRVDRSGPTLVDRDLATATSVLADVKNGFGSLATAAKDFNGDPGPLKTSASSLLAKVDSGTTAIKNMTPLSFFECLSLLTPAQDLQKQGKALSDQLKAKKALIQQYNQCVTTYDFLDQGVTKSATLITAVVSKVDSSFKETVQNEGNKITQQLKDLRDSFSPGNCSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWZ9</accession>
    <name>A0A7D5YWZ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g083680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543586.1">
        <property type="nucleotide sequence ID" value="XM_014688100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWZ9"/>
    <dbReference type="GeneID" id="26243763"/>
    <dbReference type="KEGG" id="mbrn:26243763"/>
    <dbReference type="OrthoDB" id="5145289at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="220" mass="26028" checksum="E73C6BD13ED6A799" modified="2021-02-10" version="1">MKTPSPNAKRGFDKFFASTEGHEDLCQRLDAAIRQQQEATPEPSSDHESLEEDHRWQCTILHEHFGSSDIDKMRNAIWQPDYWKIECQHYANVLNQFLLRDTDGTATAQRWRTAASMYKDLLRLNGLSIDDIRLIRHSIESQKYWEKEKDVLQQQVALREHEMHEAACARKKDIQRQRRERVRRRLRAIEEEETSPPPNPKQALRLDSIATRTRLRSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXJ8</accession>
    <name>A0A7D5YXJ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g034780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
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    <dbReference type="KEGG" id="mbrn:26239436"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="28600" checksum="64D1C7406DBCC9B7" modified="2021-02-10" version="1">MPTTASSPPRHASPPTSLSIPPSTAAPTQPHAITAHAPPAPLQQTLPSQETQRHVAEARAAVVASMGNLIDSQLQSRAGILHDNAAALDKQERDVVRATEGLRRETEKLAREADAAARRVKELGNVQNWAEVLERGFLVLEETVRLANRQDGGSESGSGSCSCSCSECGGDESGGGDEEEEEEDDDGEYGEEGMMDVDVDLANSMHRDGNKVSLEARLAVGADADMVTTEAEAEEGGRSTWSDASRSLMEPDSSTGTGRAKGSETASLSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY11</accession>
    <name>A0A7D5YY11_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g003560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129553.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90967409"/>
    <dbReference type="KEGG" id="mbrn:90967409"/>
    <dbReference type="OrthoDB" id="10458523at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028968787" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6567" checksum="65D2CD79AFCF4549" modified="2021-02-10" version="1">MYTISFVVACLAAVAMAAPAPAPIRDQLSAPRINQRDVAVPKTNDKQVAALYDNGYAPPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYA2</accession>
    <name>A0A7D5YYA2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546023.2">
        <property type="nucleotide sequence ID" value="XM_014690537.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYA2"/>
    <dbReference type="GeneID" id="26240446"/>
    <dbReference type="KEGG" id="mbrn:26240446"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="1">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="353" mass="38991" checksum="7DF42DC81818BF99" modified="2021-02-10" version="1">MTACNESSACTAKAVISCPCGVRTQEVKCLASSSNATPSRIEIKCDDECLRLERNRRLAAALNIDPTSHQNDHIPYSDTTLRLFKENTSWAETQEREFRVFARSPNEVRLRYKPMSTTYRQFLHVLAEDYGLESRSEDIEPYRYVIVFKGTRFVSAPSKTLSQCIKIRAAQAADAASAAASRAPSPPLTVQDPFNGFLLTSPRFGLTIDDVKTSLNSDLSTQPSVHFEISFLPSDEVLLRATTSYSSFLSPPALEQVLISLKPRLARTIQGSDVAGKVFLCHVDSAGHVARRDDVSKTDASGWSAVAGRAAAKLDTAVEEAPRTTGRRLVGLRKKKIERERSWTQELDGDVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYJ8</accession>
    <name>A0A7D5YYJ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g098950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987743.1">
        <property type="nucleotide sequence ID" value="XM_066131553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYJ8"/>
    <dbReference type="GeneID" id="90968172"/>
    <dbReference type="KEGG" id="mbrn:90968172"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="9269" checksum="8CA79B841178F2D2" modified="2021-02-10" version="1">MANLNRITEELRRLEKEEELMEELLIERRRKAQLEIDEALNRLMRLRRMRCYLREKGLEMARRDFASLEEMEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ20</accession>
    <name>A0A7D5YZ20_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GANC</name>
        <name evidence="8" type="ORF">G6M90_00g066240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540149.1">
        <property type="nucleotide sequence ID" value="XM_014684663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ20"/>
    <dbReference type="GeneID" id="26246958"/>
    <dbReference type="KEGG" id="mbrn:26246958"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF165">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="255"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="620"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="848" mass="94520" checksum="5CC6409374B98FC9" modified="2021-02-10" version="1">MPQQERVPSTWELFGASSTDPSVQLQSTSQDLPFTFKFELIAPNVFRTTFSSESHPLPPHPSVIIPSLGQRVLKANTLVGSGGTSKEIRIGDIVANVDWTESSPLVSISYADSKEPIHTDLPHRSYVVDGEGIAHYSRYKRGTLHVGLGEKAAPMNLSGRRFELSATDSFGYDVYKTDPLYKNIPLLINATPAGCVALFSTTHGRGKYSIGAEMDGMWGHYKVYRQDYGGLEEIVIVGQTLKDIVTTYAEFAGFPLLVPRWAFGYLSGGMKYSMLDDPPASEALLELARKMKEHDIPCSAYQMSSGYTVAEQEPKTRNVFTWNRHRFPDPQGWIKEYHKLGMRLIANVKPYVLASHPEYQKLKDSGALFTDPHTKTTAVTRLWSAGGGESDEGGHIDFTSSAGFSWWFNGVKKLREEGIDCIWNDNNEYTITDDGWQCALDQPSLEVPEGLRGRRDVGLWGRSLHTELHGKASHDALLEADPDNRPFVLTRSATAGTMRYACSSWSGDNITSWSGMKGANALSLTAGMCLMQCYGHDIGGFEGPQPSPELLLRWVQLGIHSPRFAINCFKTGDDNNVGDVIEPWMHPSITHLVRKAIKRRYAMIPYLYSLMLVSHQTAIPPQRWTGWGYESDPQVWTPEIMDGECQYWLGDSILIGGVYEPGVSSARVYLPKQSESDEGFLNLNAPYQHFQSGRWITVDAEWHGAGIPVLAKVGTVIPIGHDVQVLSPGEKENVADLPLDDYRAVEIFPPPGKSAKDWYVCDWYEDDGVSTASKVKISKYTISYNATESQVRINFTREEKSGFVAPWKTLVAILPAGDLRTVVSEDGMEVRALKPDEQGRRHFELRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZA8</accession>
    <name>A0A7D5YZA8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g005100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542157.1">
        <property type="nucleotide sequence ID" value="XM_014686671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZA8"/>
    <dbReference type="GeneID" id="26245188"/>
    <dbReference type="KEGG" id="mbrn:26245188"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="206" mass="22811" checksum="FD19E2E873C6D630" modified="2021-02-10" version="1">MNTSTEVSHKRFKLRKKLLSGTYTFVPETTGGGTDYSMDIKPRTNSKMPFMFLFEGKIVVGSVRRPMNSATFEVSLGNTENKVQREEWRAMQRTGRKEGTWTVPSSCTSGMKEVAWKGTVDVAVDGISAGLNRPGYQLVDVSNDESDEVLAVFTPMKGLSKGGVLQLNVYWGEEFERMVMLTFMCLYDRISTQATDAIGRGAAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZH6</accession>
    <name>A0A7D5YZH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g029220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985885.1">
        <property type="nucleotide sequence ID" value="XM_066130025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZH6"/>
    <dbReference type="GeneID" id="26245882"/>
    <dbReference type="KEGG" id="mbrn:26245882"/>
    <dbReference type="OrthoDB" id="4941480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="241" mass="25608" checksum="5D55FE360AD3E5B7" modified="2021-02-10" version="1">MPLPTLPSAGDCAPGGVCDCSRIPDKNSNEYFQCVTNPNCEYCWVGRSTTSTSSSSKTLVANSTSISITDYHTMSPGTYTITTNGTVINIVVTQEIATPTSSTQVFVTMTETVVVTVSSASTWTAGKSSSTATVDDDCYGRCNCSKVEDKDSKGFFECLTNPDCEKCHSTNAAALATETAASSRISKSSASSSTTTTSSFGAPTDACPFFCDCSGIEDKDSEEYFQCITNPVCEQCKSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z059</accession>
    <name>A0A7D5Z059_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylcholine phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540451.1">
        <property type="nucleotide sequence ID" value="XM_014684965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z059"/>
    <dbReference type="GeneID" id="26246813"/>
    <dbReference type="KEGG" id="mbrn:26246813"/>
    <dbReference type="OrthoDB" id="5182398at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029001763" description="Phosphorylcholine phosphatase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40212" checksum="76782F9980C9CC91" modified="2021-02-10" version="1">MRSTWTVFGLAAVAGLADAAPADQKIKCPAGPRLAHWPPEAAKALNQMIARNAHKGRYAVFDMDNTSYRFDLEESLLPFLEAKGVLSRDKLDPSLKIVPFQDTASYTESLYSYYLRLCEIDDAVCYPFAAQVFGGLPLRQLKAYVDELMAFNGTIPVQYYEEGVLTNATVSPPKVFRGQAELYNRLMANGIEVYVVSAASEELVRMVASDPKYGYNVKPQNVIGVTLLMKDLQSGNVTSARKQIKEGDYSESKNLDLVMTPLLWTPATWKEGKWAAILDYIDPWKRPILAAGDTPVSDGPMIFQGVDVGRGGIHLWVNRKDKYMEQIDKMKKDFAAAQEREGLPVWADKNWVTVKPDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0V4</accession>
    <name>A0A7D5Z0V4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g000710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985625.1">
        <property type="nucleotide sequence ID" value="XM_066129491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0V4"/>
    <dbReference type="GeneID" id="26244370"/>
    <dbReference type="KEGG" id="mbrn:26244370"/>
    <dbReference type="OrthoDB" id="4932619at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25770" checksum="D06479F129DC8BF7" modified="2021-02-10" version="1">MCAIADKSGDGELNPNKASFQHIYSEPTPLGYYKTLTPLGYGDYHDQFAQLIDTNKPNLRLGVRRVIDIGCLYGSTAIAYAQGARWTQSIQPRAVSHLDMTGVDISENALQFGLKAGIFTKVINQDLNGALSRDFYHALDNADALLCMMCLSYVRDGVFASVLRRFAQNGGKYAIYSTIPMFDDRCYSPKALGIEVKWSKSVVLRHRALTDDEVKMNGGVADSFVRVYLVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1C4</accession>
    <name>A0A7D5Z1C4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase af470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">af470_1</name>
        <name evidence="1" type="ORF">G6M90_00g080520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539383.1">
        <property type="nucleotide sequence ID" value="XM_014683897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1C4"/>
    <dbReference type="GeneID" id="26247827"/>
    <dbReference type="KEGG" id="mbrn:26247827"/>
    <dbReference type="OrthoDB" id="3202396at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025444">
        <property type="entry name" value="Monooxy_af470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13826">
        <property type="entry name" value="Monooxy_af470-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="279" mass="30931" checksum="F8B1D3D0F2F23612" modified="2021-02-10" version="1">MSTNFTGRLSPSDGPHQFGPKSIYSKYVLRVSRLHGVVKYALFQLVISLLVPSKYAIIPCAIVILCFTANIIIHATTPCTGVNPFMENVVLGRTTSQVPFSDGSFGSEPAAQGLVVFNLGIQYNHPLGPLCPLGMEIADRFQKMNKDMLRRREELGLLSVNYWKGATADSENMAVITYYFRNVESIHRFAHEPLHRATWDWYKSHNPTHIGIYHETFIVPEKAYESIYENCSPIGLGRGSVKSVHGKSGNSWVNTLVSADTPALKSQTARLAGSLRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z204</accession>
    <name>A0A7D5Z204_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aldolase vrtJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">vrtJ_1</name>
        <name evidence="11" type="ORF">G6M90_00g085530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541111.2">
        <property type="nucleotide sequence ID" value="XM_014685625.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z204"/>
    <dbReference type="GeneID" id="26246100"/>
    <dbReference type="KEGG" id="mbrn:26246100"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06502">
        <property type="entry name" value="TA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="9">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="10">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="922" mass="101508" checksum="4275CC7DE62E55DA" modified="2021-02-10" version="1">MSNSNTMPGFKGEHNAWIGAKGPAAFDLRSDVMTTPTPSMLAAIQSCTLRDDVFREDKTTMELEAHVAALSGKEAGLFVLSGTMGNQLALRSLLAQPPYSVLCDHRSHIIQYEAGGVSTLTGATVMAVVPKNGVHLTLEDIKKNVVLSDDVHACPTRVISLENTLNGMIMPLSEVKRISDFARQHGIKMHCDGARLWEAVAAGAGSLPEFCAHFDTISLCFSKGLGAPVGSLLVGSQETLKHSRWVRKSIGGGMRQPGFITACARVAVDETFGKKADGSDGWLKASHDMAKKVEALWSGMGGKLVHPVHTNMCWIDLDSAKCSDDRFIELSRTAGLTVSGGRLVTHYQIAQNGDDILRKLGDVFQKVFAEPEEVSSGAGVKSIHGVPFTTWNGVEPLPGTDQSGYCTHSSVLFPMWHRPYLALFEQQMHKMVNAIAFMFTNATERRLYQRAASTFRTPYWDWSLPAPSGETHLPDVFWSPIILQYGPNGLQNIRNPLYSYEFHPLDKEAMIWNPLKQWNETKRAPNTTLSLTSPPSNNEEVNKALLSKLPELQQRLYILFSSYHEFNSFSNKAWAVSQGLSALDSIESVHDVIHMYGGSKGHLTYVPLSSFDPLFFLHHTMTDRLITMWQILNPSSWITPMSAGETSFTALKGTMQSSESALTPFFATDDGKFWNSDMARTTIAFGYSYADTMAKTGYNEDLREALVKKINIWYGSSSPVGLMENKAGSRWSSPETKKPANAGHGRSSFRPNIKYDAEDPHASSIFKGNHYTEWVANVEVNVEALDGSFVVHFFFGLPPQDEDNWHLAPNLAGTVAIFAMNRMTGSESKISGAIPLTSAIIKMVAAGEVNDLTPQEVQPFLTDVLYFAVQSSNNSQVDPRQVDGLNILVASSNVKIPRTQSELPEWGSSVTRLRLWPLNSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z273</accession>
    <name>A0A7D5Z273_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLL-like beta propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g050390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545146.1">
        <property type="nucleotide sequence ID" value="XM_014689660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z273"/>
    <dbReference type="GeneID" id="26242487"/>
    <dbReference type="KEGG" id="mbrn:26242487"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22954">
        <property type="entry name" value="PLL_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029004132" description="PLL-like beta propeller domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PLL-like beta propeller" evidence="2">
        <location>
            <begin position="107"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="37597" checksum="F720F1669D01D807" modified="2021-02-10" version="1">MLKHSLLYCLSLFATTQVCNARAVEKEIRAPAAQSWRGLGGLFSGHPGVVSWSANRTDVFVRGTNNAVYHKWQNGDSGSPWGPSQTDYENLGGVIYGDVTAVSWGPNRLDLFVLGTDNAVYHKWWDGSSWGGWESLGGTIIGEISAVSWGANRLDLFVRGTNNAVYHKAWNGGSWSSWVSLGGVIVGNPQAVSWGPNRIDVFVRGTDNGVYQNAWSGSSWSGWYNHGGVIVDDVTPVSSASNRLDLFVRGTNNALYQKSWSGSAWTAWISLGGTIVSRPSAAAWDGRYVAVVAQGTDNAVYLKEYNGNSWADWRSLGGVVTDAPVINPRGGFGAAVFARGTNAALYAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2X3</accession>
    <name>A0A7D5Z2X3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SUP35</name>
        <name evidence="17" type="ORF">G6M90_00g039550</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547309.1">
        <property type="nucleotide sequence ID" value="XM_014691823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2X3"/>
    <dbReference type="GeneID" id="26239872"/>
    <dbReference type="KEGG" id="mbrn:26239872"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="271"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI67366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="704" mass="76635" checksum="541751490A18A729" modified="2021-02-10" version="1">MSNLNSWEDDPAAQDENLSRRAQQQLNVNAGQGQGGFRPGAASFQPGAQSFQPGQPYGGGFSNQYQQQQQQQYYQQGYYPQYGQQQGFNQYNQGGYGGNFSQGYNQGYGGGYPQYGQPGQAQQQPTQAPASAAPAAAPTAPKVLTKEGGPKVLSIGGDASAPKPKAKVLSIGGSGTSTPTKDKEEAKPEPSNKPEAGQKAAAVKAIEKTGEKAGKAASSSKSSGRTSPTPSSGRSSPSGPGEKKAQREVDAVTKEQAADVDDETLKEVYGKEHVNIIFIGHVDAGKSTLGGSILWTTGMVDERTMDKYKREAKDLGRESWYLSWVMDLTKEERSKGKTVEVGRGFFETEKRRYSILDAPGHKTYVPNMIGGASQADVGILVISARKGEYETGFERGGQTREHAMLAKTQGVNKLIVVINKMDDPTVEWSQERYTECTTKLSQFLKGTGYNLKTDVFFMPVAAQSSLNIKDRLPKGIAPWWEGPSLLEYLDGMSALERKINAPFMMPINAKYRDLGTMVDGKIEAGVVKKGMSLVMMPRKQTVEVSAQYGEQEEEVPILQCGDQVRMRLKGVEEEDILPGFVLCSPKRLVHCVAEFEAQIRILDLKSILTSGFNCVLHVHSAIEEVTFAALLHKLQKNTNRKSKIPPTHAKKGDSIIARMQVIGGAGSVCVEKFEDYPQMGRFTLRDQGQTIAIGKITKLITNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3K8</accession>
    <name>A0A7D5Z3K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g089650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541626.1">
        <property type="nucleotide sequence ID" value="XM_014686140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3K8"/>
    <dbReference type="GeneID" id="26245489"/>
    <dbReference type="KEGG" id="mbrn:26245489"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="37927" checksum="C7790C72919031EE" modified="2021-02-10" version="1">MAEADFEIDFYGDTATDQQSEHQDGNQHNESDYQGHDETNGGDEHTDSHKGHHDDHHEQAESHTHQQGIKRKSEEDDRPVDPAATSALMVSELSWWTTDDDIRGWLRKADGETDIKEMTFSEHKVNGKSKGQAYIEFYSRQAATSAKRCIDQLANDGGQSWQKKLLPTYWNSAVNPFRTLPKDAPARGVKEQPRASPPGPYAERGNYSGGYRGRGGFGNRGNMNQGNFNTNRNYNNSNMGFNNNMGGGFNGPMGGNFGFNNRGNMMGGGMRGGPGGMRGNRGGGNMMGMNPMGGMPMGMPGNMGMMGMGGGMPGFQGMGPNFGGGFGFGQNQGGGGGDWGNPHGVKRPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z560</accession>
    <name>A0A7D5Z560_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CYAA</name>
        <name evidence="21" type="ORF">G6M90_00g099360</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
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        <property type="protein sequence ID" value="QLI73185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_014546411.1">
        <property type="nucleotide sequence ID" value="XM_014690925.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240834"/>
    <dbReference type="KEGG" id="mbrn:26240834"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000408">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052595">
        <property type="entry name" value="LRRC69/RLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE/THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48057:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="631"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1432"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1772"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="244"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1108"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1192"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1193"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI73185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2168" mass="239750" checksum="72BD99254A6E4746" modified="2021-02-10" version="1">MTDNEAVSRISSYTSASASTDSTRSSMTAMPPTPPLASMSARRGSSMRIATDGGYRWRTSKDDAQVSPTSTTATRGTLSPPSSNSAPSIPPKDRRLSDLTNYRRDLAVLEPTRSHPPSSSSPSSSQVPPPQHSHSVGSLAASTQIAPWMSSALPASSSPKGLTTTFYNDSSDSLSLASQLSPGLPSATGRPGTGSGSISQDYADVLYENMDGRRPSAASIVTTASSQGSKASVNRGGFRKLQGFFGEEFPGHDSSESSLPISVPGKDQRSRSYSHGRPTQRDRNYSNATDREPSPSSSRPRTPVPNPEVVPFLYQDNSDIARYGEAPVRDILTGPDRERYESSAGQNPPKSSSSARSGPVHHLHGHHHRHNKSNDDPRTLRPIASREDSLGSGQHGRDRGPSVGMLNQRSRAHSPTPSANSGPPGSRSGFHADGSTSPGHHGKRGILGRLRRHKDKDDGTSRLRDLPPSTRSLQVKPSKADMQRPDIFPGYYPGTPEPGETLDPRTGAHRAATFNNKFPFSKKTRPQRPFDYTDEAIGPTDYNDPGHVYHLDTNLNDMEGILTKPPPLTPMDSSFINSIESDRRESTLEGPKGRWDAPDSWAVRRNTEDNTEDVPEVDEIGSPPRPDEKLTSYFIRIFRSDGTFSTHSMALDSTVTDVISQVIKKTYVVDGLENYHIIMKKHDLIRVLAPAERPLLMQKRLLQQVGYEEKDRIEDLGREDNGYLCRFMFLSARESDFHAKTMDLGISRSQKLNYVDLSGRNLVTIPISLYKKAADIISLNLSRNLSLDVPRDFIQSCKQLRDIKYNNNESRKLPLSLGRAGRLTFLDVSNNRLEQLEHAELNSLTGLLKMNLANNRLTHLPPYFGAYQALRSLNISSNFLDKFPPFLCQLHSLVDLDLSFNAIASLPDELGNLKNLEKLLITNNRLADEVPEGFRQLLSLRELDIKYNSITSIDIISELPKLEILTAAHNHISSFVGKFETIRQLKLNSNPLNKFEIIEPVPTLKTLNLSHAQLASIDSAFSNMINLETLVLDKNYFVSLPQQIGTLSRLEHFSIANNSVGELPPQIGCLTELRVLDVRGNNISKLPMEIWWANKLETFNASSNVLDAFPKPASRPPRVPGEEPTGPPTVQNGKPLPPNPIPSTPSSEDLSDERRPSQASSTLLSVGPSPVLATADRKSSVVSVYGKGGRKTSVVSRAASQATNSTTPPPTTTRKDSGLSSRLTNTFAGSLRNLYIADNRLDDDVFDQIILLSELRVLNLSYNDEISDMPQRSIKNWPQLVELYLSGNGLTSLPADDLEESSLLQTLYINGNKFTNLPADISRAKKLAVLDCGNNYLKYNISNVPYDWNWNLNPNLRYLNLSGNKRLEIKQTAWGGPDGPGAVNREQYTDFSRLLNLRILGLMDVTLTQPSIPDQSEDRRVRTSGSLAGHLPYGMADTLGKNEHLSTVDLVVPRFNSSETEMLLGLFDGQALSSGGSKIAKYLHENFGHIFAMELKAIKNRPDDTPTDALRRAFLCLNKDLVTVAVQHTEERPKAAHRGSAQPVVLSKEDLNSGGVATVLYLRGTELYVANVGDVQAMVIKTDGKHEILTRKHDPAEPSERSRIREAGGWVSRNGRLNDLLQVSRAFGYVDLMPAVQAAPHVNKMTIKEHDEIILLATSELWEHLAPGLITDIARSERQDLMRAAQKLRDLAMAYGASGKIMVMMISVADLKRRVERSRLHRGTSMSLYPSGIPDDTQVLSTRRRGKAKGDVLDSSLNRLEAEIPAPTGNVSIVFTDIKNSTTLWEMYSSAMRSAIKLHNEVMRRQLRRIGGYEVKTEGDAFMVSFPTATSALLWCFAVQMELLDVSWPSEVLNSMSCQPIFDKDGALIFKGLSVRMGIHFGDCVSETDPVTRRMDYFGPMVNKASRISAVADGGQITVSSDFISEIQRCLENYQDTERNASGGSDEAFEDESFAATIRKDLRSLTSQGFEVKEMGEKKLKGLENPEVVYSLYPHALAGRIDQHQQHERRDEGLDRPAILAPGSELSFDPESIWALWRVSLRLEMLCSTLEEVRGSGLQPPETELLERIKSRGGEVTEKFLLNFMEHQVTRIETCVSTLVMRHLALGQPIIKELNDLRGPMSLVLDYFVKQQEELARYKQFYGDMPPEGDASGGKTQRAIASAHEIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5D2</accession>
    <name>A0A7D5Z5D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="3 15">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TERT</name>
        <name evidence="18" type="ORF">G6M90_00g099740</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Chromosome</location>
            <location evidence="15">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="3 15"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546375.2">
        <property type="nucleotide sequence ID" value="XM_014690889.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5D2"/>
    <dbReference type="GeneID" id="26240798"/>
    <dbReference type="KEGG" id="mbrn:26240798"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 18" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10 15" id="KW-0779">Telomere</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="619"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1115" mass="126060" checksum="CE946ED455E3B293" modified="2021-02-10" version="1">MTSGRKRKRHERDASNSDNGVVACDGPVRRDLLRHAYATVLTLREYALLKLPSSSRLRRKKISSLGKGNSVSELEAAVSEFLDSTLICDSKAILQTDNALYAQWLSFSQNGDESHVTISGDLPASENTLSELVDFAIWSLFNRQKTPGAWPKHLLCDGYRKRTKEGDPQNTSIPGVWREYPNHHAAALRRQPWPQVLALLGHSGQRVMVDLLIERSIFVTIDAGIGNYYQISGIPLSELQFGGNRSSSNEPRKPSDISLVRSRIFYARPVLTARGRVRHGFKSIHVLNRCCAGKDDGTSHHAEKMKASTTKLTMYMFPRQFGLHNVFTSNVNVSETAQKFQDYTSREEEIKEFTKDPKHCSKNGTPRLPKRLRGEAWRLVQRLQILHSRCSYEELLRHYCPSQIGGSRAHESSFPLDERSQVTDLGKGQRRIEPPAPVATNDRQQIIPTPKPPLGGFQSNSVVKLATSSSQVSAFCQAALTHIVPNDFWGTGETLFHNKAMFLRSVDHFIRLRRFETMTLHEIYQGMKTAHIPWLQPPGVGTQKAGLTDIKKRCELFYEFLYYLFDSLLIPLIQTNFYVTESNTHRYQVFYFHHDVWRRIAEPTLSVMKSDMFEEMTITSANEILESRDLGFSQIRLLPKGQKLRPIMNLRRRQPTRTGAKVLKRSINSFLGPVHTALKFEKMTNPQQLASSLFSVSDMYAKLKMFKLSLPSGSSQLFFAKVDVQSAFDTIPQDAIIQLMKSIPSQQGYTFTKHAEVQPGERAMMAPEKTATKAIRRWHASVLARDMPPFVDRLRHGLASKKRNTVFVDRVALEGWDTESLLSLLADHVQRNLVKIGKKYYRQKRGIPQGSVLSSFLCNYFYADLERKHLGFLLGPDCLLMRLIDDFLLITLDKNKAVRFVETMHHGVPQYGVEVSPGKTLVNFDMQIDGKPVCKAGTTGFPYCGTRIDDRSLDITKDGEAKAAICVSNSLTVDYGRSAGQNFQRKVINAFKIQSHLMFFDTSHNAPRTVLDSLRGAFAETARKMWAYIRCLPKGRQPSTALITRTILKVSEVAFSIISSKSRKLRYPEYSCCIQKGQVMSAANDAFLDVLGKKQANYGPVIAWLKAQNKKSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5F9</accession>
    <name>A0A7D5Z5F9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g057710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5F9"/>
    <dbReference type="GeneID" id="26242765"/>
    <dbReference type="KEGG" id="mbrn:26242765"/>
    <dbReference type="OrthoDB" id="5376312at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="476" mass="52620" checksum="C0EE660B8874E2FC" modified="2021-02-10" version="1">MRLPHPPLPRTSTSHIVTEPTRQLRRRDLNTKNLTFIIIFVVIALFAFIAVLLVAFFRARRRRPDDQDAGSGGQWPVLHVFRRKRVGHRRYEQTSGENLDGEAQIHQLEPTAVSANHVNTLQRDSRQSGSRAARANRTGASVDRNTSVRSVMTLPAYRATAGNNEQVLGREGDRDGVDVIVDLPTAEEEESLREEEMEAIYQIRIARREQIAQRDELRRQRRDARQRGDNNTLADDRARSRAASNNSNLDELRQEVSRIQDQRQRSVSSVSYADLGVARHDGTRIRASSNESERIGLLSDAASIAISARSEVASSLGLHRREQSVSSLVSVDSEFIPEPSRARANSGSTTPGLLSGEPAAGSSPEHVQDDLGVEPTPPPGYEVVSIEDDDREVAGPMTPLNEPPPDYSGPNEHMPQTEQTSTEPAHPSPREGRTPSPLRTARGVGGAPQLPSLRISRLPAIVIQPLNEESRDENVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5K1</accession>
    <name>A0A7D5Z5K1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA-processing factor 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">prp39</name>
        <name evidence="7" type="ORF">G6M90_00g097300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546611.1">
        <property type="nucleotide sequence ID" value="XM_014691125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5K1"/>
    <dbReference type="GeneID" id="26241034"/>
    <dbReference type="KEGG" id="mbrn:26241034"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000451">
        <property type="entry name" value="mRNA splicing protein (Prp39), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000064">
        <property type="entry name" value="Putative pre-mrna-processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="586" mass="67873" checksum="01DB9C4A5101BBC2" modified="2021-02-10" version="1">MSEFAPFGGSDEEYASVRKHQAEVEADPDNFESWENYIKSSETLDGGLNRNSSPQALATFREAYDRFLHKFPLLFGYWKKYADMEFNIAGPESAEMVYERGCACITNSVDLWTDYCSFKMETTHDPQIVRDLFERGASLVGLDFLAHPFWDKYIEYEERQEAQDRIYAIHARVIRIPMHQYARYYERFRNLAHTRPLSEVVPADVLSRFQAEVEAESAAQGGGARPELEIERDIRAKIDAMYYEVFTATQQEVSKRWTYESEIKRPYFHVTELEHSQLNNWRKYLDFEEAEGDFDRAVSLYERCLVTCAFYDEFWFRYARWMAAQDGKDEETRHIYIRASIFVPISRPGIRMQWAYLEESCGRIDVAIDIHAAILMKLPDCVEVVVSWAHLQRRQNGLEAAVQVYRDQIDAPTVDLYTKAALVAEWAQLLWKVKGSAEDARAVFLKNSQWYGDSLVFWEKWFAFELDQSATGEEEKDTAERIKSVFDEFRTKSKLSGSVKQELARVYMNYLVQRGGKDAMTIFLEVDRDMFGPASISKSTIASKENGTTGGELDEASRRKAEARLFAFYETHTEPNTAAQGPADFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5T4</accession>
    <name>A0A7D5Z5T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Inositol transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">INT1</name>
        <name evidence="10" type="ORF">G6M90_00g040100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547360.1">
        <property type="nucleotide sequence ID" value="XM_014691874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5T4"/>
    <dbReference type="GeneID" id="26239923"/>
    <dbReference type="KEGG" id="mbrn:26239923"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="556" mass="61137" checksum="C522703B84E986F6" modified="2021-02-10" version="1">MGGGGNDKAEAEALEVARAGGHQVDTLIGEMEQELEASGGLKRGFFNLEFKDPKHFTWLLVAFASMGGLLSGLDQSLISGANLYLPKDLGLTPRENSLVNSGMPLGAVGGALILSPANEYLGRKGAIYLSLVLYTIGAALEAGAIDFGMIVAGRVILGLGVGLEGGTVPVYVAETVERRIRGNLVSLYQLMIALGEVLGYAVAAIFLKVPGNWRYILGSSLVFSTIMFFGMLFLPESPRYLMHKGKALDAFKVWKRIRGVETTESKEEFYVMAVAVRQEASTVTEVAKNRRFPWMDFFTVPRARRALIYANIMILLGQLTGVNAIMYYMSVLMSQIGYEAEKANYMSLVGGGSLLIGTIPAVFLMETCGRRFWAIMMLPGFFIGLVLIGIGYQINIETHTMAAEGCYLTGLIIYMAFFGSYACLTWVVPSEVYPTYLRSYGMTTSDALLFLASFIVTYNFTAMEEAMTRTGLTLGFYGGIAVLGEVYQVFFMPETKNKTLEEIDLVFQRPTMDIVRENWAGVKENMTDLCHGRFRKVFVAQTDRRPSVDELEKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6G2</accession>
    <name>A0A7D5Z6G2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g105950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987843.1">
        <property type="nucleotide sequence ID" value="XM_066131692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6G2"/>
    <dbReference type="GeneID" id="90968211"/>
    <dbReference type="KEGG" id="mbrn:90968211"/>
    <dbReference type="OrthoDB" id="4961250at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38064" checksum="3118E175353D6FEA" modified="2021-02-10" version="1">MFDAHFRVGGAYGSSKAHPGGLPQGHQHPQRLYGASMLFHVTPKANGYFENVWGWVADHDLEDPKNTMVTVAVARGFLIESNDGPTWLYGSASEHSILYQYNFYNTGNLFAGMIQTESPYFQYTDATSSPGPFKNSLGAAMFSQVSNVTIAGAGLYSWFDAYDQSVCVDAQNCQQRLIFDQGGNGELWVFNLVTIGSVEMISDDSGAIETAKENTQANAHPFWSALAVWGDESDPLALLCDEEDTDPGCLHNDACDLSKDFADMDALVAAQGSIPPEFAPYYVVNALSNLLEGSLGAYDGANKGYDAVWEYYAEGFRGSVDAMIRKFTADSTPSNRNGGPGIHYFEASSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6Q2</accession>
    <name>A0A7D5Z6Q2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g040400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547388.1">
        <property type="nucleotide sequence ID" value="XM_014691902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6Q2"/>
    <dbReference type="GeneID" id="26239951"/>
    <dbReference type="KEGG" id="mbrn:26239951"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="400" mass="44269" checksum="6634201CBDA620FD" modified="2021-02-10" version="1">MHYIRLLRAPRMQVDEGGMQAELVFTITTDLGESFLCPEKAIDLVVTAHVTSVSENSSCLLTRRGALQWKAGRRVCKPVFEFPPMIQQAFINGDSVELCISPDSDLSGDEVESILNSSIKRAKKHANGLIVPVWVGMSGPEVDFDVSTRRIRLTAPTEPAQFLEIEEEIGESIARHIWDAGVVSLCAVVGAYKFPKLETSQHPCMKKLLSILNNKDGVSVLELGCGVGILGIGLCAVYPRDTGECTILMTDVGEAEGRVRNNIGLLQQLRSGSDLGYAQVMYQNLDWNEAKDGSFRGQIQYRRWDLIMLSDCTYNVDMLPALVGTLSAIHHANLQFTADDETFSTKVFVATKPRHPSERSFFDLMAADGWTREEKQVLSLPVLSGECESVEMYLFEKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z732</accession>
    <name>A0A7D5Z732_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Laccase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Conidial pigment biosynthesis oxidase Mlac1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gedJ</name>
        <name evidence="16" type="ORF">G6M90_00g052500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Laccase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress. The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA. The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pigment biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986714.1">
        <property type="nucleotide sequence ID" value="XM_066130545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z732"/>
    <dbReference type="GeneID" id="26246740"/>
    <dbReference type="KEGG" id="mbrn:26246740"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028925237" description="Laccase 1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="64"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="190"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="420"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI68968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="68144" checksum="9825E8548EF0E398" modified="2021-02-10" version="1">MALLRRLTQLLALCHGGFASKPKANCSCTNSPQHRDCWRQGFNIHSDPDKVVPKGRLREYELTVTQELIAPDGYLVKGTVFNGQYPGPLIEADWGDTLRITVHNNLTNFNGTGVHWHGIRQSETVWLDGVPGVTQCPSKPGSSQTYEFRAMQYGTSWYHSHFSLQYSNGLYGPLVIHGPSSANWDVDLGPWLLSDWYHDDAFKLYYYEIFTPRAAIPNSMVLNGKGLYDCDPKNDTRCTGKKDFFEVTLERGTKYKIGLTHTGTLLTETFWIDGHNFTVISNDFVAIEPYVTDVINIGIGQRYEIIVEANASLENGPNFWIHAQYCNEPDILDHRVGIVRYDAKNKSDPYTPPRAHLKYGCADPGPNELVPVVPMQVGRRVNNMEPSEYLKIGLQGWPNASDPNSLIHKWVLRHTPMYLDWREPSLKKLALNTGNASLFTPETEPIYLDYETGEWVYFVITSNYTLEGVDPPRTIPQSVHPMHLHGHDLLVLAQGQGPFTEDVVPKLDNPPRRDVANCPIDGYLWIAFRIDNPGAWLMHCHIAWHASDGLSIQFLEQPGKIKGLMEKAGVMPEFSQRCEEWTEWYENNNMVHEAEQDDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Z9</accession>
    <name>A0A7D5Z7Z9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General amino acid permease AGP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AGP3</name>
        <name evidence="10" type="ORF">G6M90_00g110320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543827.1">
        <property type="nucleotide sequence ID" value="XM_014688341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Z9"/>
    <dbReference type="GeneID" id="26243214"/>
    <dbReference type="KEGG" id="mbrn:26243214"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="63"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="61194" checksum="62BFF701B5549B0F" modified="2021-02-10" version="1">MFWKTKSAEKSHAEPHPRDSSADIFDDEVENTRFNTYGSPRDISDASLIDPDSGVKRGLKNRHLSMMALAGIIGPGLLVGAGGALNNGGPASLIIGFGVIGVIAFAIMQSLGEVTTLFPGGGSFVSLAERMVDKSFSVAVGWNYFIIWAAVLANEYNVICSILTYWAPQVPLWGFFLILWFLFTAFQLLGVEAFGEAEFWLALFKILGLTAYFIFSIVYAAGGLVGQTDSLGFRYWHDPGAFNGNGFRGVAVVFVFCSTFYAGIESVAVAATETRNPGVAVPQAIRQVFWRIIFVYMGSALFFGITCPANADGLVNGGAKALQSPMTIAIQTAGWNGGVHLVNAFILITCLSAINSSIYIGSRTILYMAQSGKAPRFIGRTNKKGVPVWAIVLTNAVGSISMMNVSTGASKAYGYIVNLSGVSTFLVWGSISFIHIRFRRAWTAQNRSLDEIPFRSMFYPFVAYFGLVANLFLALVQGWTTLSPFNAGNFVDAYILLPLFGLIYLVGKLYWGNDDKFKRSSEIDLDSGRRIDLDGKGIMPEDEAYIETGRASIWRRIWSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9A8</accession>
    <name>A0A7D5Z9A8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras GTPase-activating-like protein rng2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rng2</name>
        <name evidence="5" type="ORF">G6M90_00g057330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544317.1">
        <property type="nucleotide sequence ID" value="XM_014688831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26242729"/>
    <dbReference type="KEGG" id="mbrn:26242729"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="293"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="722"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1676" mass="191819" checksum="F01477883B7CA365" modified="2021-02-10" version="1">MSFQSHRLRQSRTADLAPPTSFTHNNISTSISNINRFPSTTSSSASSGYSSTSDRSNVTQYTSASSDHGSPAGRKHKRGQSDVLARARTFEAGAMSGFNTGPANPPATPTRQSVRPLPQAPTASPRSPAQGASPRSSLRHDRGQSIDIGKLSLSQYDGPVAPPTSPPRPLPMRPNSMLLTRSDSILQAKTPMPHGSSPQGSHTTHIGRPDLELLGRSTTRELRTLSRLAESDVAEDFTITSSAQEVVGLRGRRRLQRTDKHTGARSAKSGGYGWEGRNWMDKQRQFLQAYEYLCHIGEAKEWIEDVTQKTLPPIVELEEALRDGVTLANVVEALNPQRHFRVFHHPKLQFRHSDNIAIFFRYLDEVELPDLFRFELIDLYEKKNIPKVIYCVHALSWLLFRKGIVDFRIGNLVGQLEFEHHELEAMQKGLDMLGANMPSFGNMGADFGVPEPEPVETEEERRDRELGENEESIVDLQAQIRGALLRLRLGDKMQQFWDEEHWLIDLQSRIRGDFTRQIMSYRLQMRRSAILTQSAARGFLVRERLRKSDAFWKAHEPEILELQSMIRANQVRDEVRDLLYSLDGCKGPVREIQAVSRGFLVRKNLAAQQQETKKTSGHVERLQALARGMGLRARISKDLQLLGGQAGTVASLQAAARALLTRTQIDREQQQLCALGPKWEALQGAIRGKLVREKQEAYKVEAQKHELNIGQLQAVIRAGAVRREVTRKLDALEESKEEILSLQSGARGMMERLKVAALQQELNRHEARITGLQAQVRGYLGRKQRHALLDELESHNEATAEFQAILKAMMTRAGVDDLLTELEEEEESIVALQAATRGFMVRAKFEEKKRYFNENMKKVIKIQSFVRAKVQGEAYKSLTTGKNPPVNAVKNFVHLLNDSDFDFNEEVEFERMRKTVVQQVRQNEMLEQYIDQLDIKIALLVKNKITLDEVVRHQHNYGGNSMGLLANSTITSANQFDLKALNKSSRKKLESYQQLFFSLQTQPQYLARLFKHLREQGTSEKEYKRIELLVMSLFGYAQKRREEYYLLKLVARAIREEVEGCRAIQEYIRGNYFWPKLLGNYTRSPRDRKYLRSLLGPLIRDNIVEDPALDLESDPMQIYRSAINNEELRTGRPDLRPLDVPREVAIRDPETRRLFIDHLRDLREICDQFFLSLEEMAHKMPYGLRFLSSQMFQALCQHFNREPQENLLQLVANWIWKFYLQPALTQPEQLGVIEKSLSPLQKRNLSEVAKVIGQVASGRPFGGENIYLQPLNNFVTDSIQRMRQILQNLISVADAESTFGVDEFNDLYAKNKPTLYIKMTDVFAIHNLVASELPFMCPTRDDVLREIIQDLGNAKSNENEMNAAGSSDIQMFLTPKLHSVQDPEEDVKSLFMETKRCVLYIIRVQTGANLLEILVKPIYEEDEEKWQTVLHDDFSNDGNTRGAYSDTNMVDVTRMTYYELKRTALENIMRLEQMGRISKQNYYQDVLNAIASDIRTKSRRRVQRQRELEGVRLTLTNLAEKAKYLEQQRKSYDDYIEQAMVTLQNKKGKKKFLLPFTKQYNHQRELERSGRVPKFGSYKYSARTLSEKGVLVSWAGLSDREWDKINITISCDEVGVFAIEGSRGHIQMPGASALVPIEDMLQAQFESHQFMNLFEGNLKLNVNLLLHLVYKKFYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAC2</accession>
    <name>A0A7D5ZAC2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="8">1.5.1.5</ecNumber>
            <ecNumber evidence="7">3.5.4.9</ecNumber>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">C1TC</name>
        <name evidence="23" type="ORF">G6M90_00g104350</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="8"/>
    <dbReference type="EC" id="3.5.4.9" evidence="7"/>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541431.2">
        <property type="nucleotide sequence ID" value="XM_014685945.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAC2"/>
    <dbReference type="GeneID" id="26245681"/>
    <dbReference type="KEGG" id="mbrn:26245681"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1510.10:FF:000002">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001123">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="21">
        <location>
            <begin position="161"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="22">
        <location>
            <begin position="298"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QLI72906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1094" mass="116320" checksum="6C862F6A95B7C8C3" modified="2021-02-10" version="1">MAPRKLYLTGRRETHSTTTSARMLGSTGSQRPSQTAAGPAAGARDFCSTCSTCLRSSRLPRPGPTCTSAAAAAVVRVAQCGGQQPAGHPQSPGTGLLPLALAHVSGTTPLSSPLSSPSRFYSTTSLPRRPARLGSSPLAIHPSLHRRQRFASSAAMTARVLDGTAIAKSIRERIGAEIVEKQKLNPRYKPSLKIIQVGDRSDSSTYVRMKLKAAAEAGVACELLQFPVDISEPELLDQIRRLNHDATVNGILVQLPLPANISEYSITSAVADEKDVDGFGTNNIGELAKRGGAPIFTPCTPKGVMYMLKEAGVQIAGKTAVVLGRSNIVGGPISYLLRHADATVIVCHSKTQGLENYLQHADIVIAAIGQAQFVKAEWLKQGAVVIDVGTNFIPDASKKSGQRMVGDVDFEGASKVASVITPVPGGVGPMTVAMLLQNVVEATNLFFEKEKIRKTIPLPLKLKTPVPSDIAISRDQKPKQITRIAAEVGIAPHELEPYGAYKAKVDLDLLKRLDHRRNGRYVVVTGITPTPLGEGKSTTTMGLAQALGAHVGRLTFANVRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAITAANNLLAAAIETRMFHENTQKDGPLYRRLVPAKNGVRKFAPVMFRRLKKLGIDKTDPDALSEEEIRRFARLDIDPDTITWRRVLDVNDRHLRGVTVGTAPTEKGQSRETGFDISVASECMAILALSTSLADMRERLGRMVVATSRNGDPVTCDDIGAGGALTALMKDAIKPNLMQTLEGTPVFVHAGPFANISIGQSSIIADKLALKLAGTEPDENHSQSAGFVVTEAGFDFTMGGERFFNIKCRTSGLVPDVVVVVATVRALKVHGGGPPIAPGAPLDAVYTQENVEILRAGCVNLKKHISNARSFGIPVVVAINKFATDTDAEIAVVREEALSAGAEDAILADHWAHGGQGAVDLAKGVIAACEKPKNLTLTYGLDGTIQERIEAIGQKMYGAAKVEFSELAQKKVDTYTRQGYGNLPICIAKTQYSLSHDPDLKGAPTGFTVPIRDVRMAAGAGYLYALAADIQTIPGLPTAPGYLNVDVDTETGEIDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAW4</accession>
    <name>A0A7D5ZAW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g083890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543606.1">
        <property type="nucleotide sequence ID" value="XM_014688120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAW4"/>
    <dbReference type="GeneID" id="26243783"/>
    <dbReference type="KEGG" id="mbrn:26243783"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="472"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="674" mass="76129" checksum="B8E6900972BC2CAC" modified="2021-02-10" version="1">MAQLFKSDDESSTVIILPQTESVDDDPMDDSTSTSNKTEGDEEKEVHLKGMMSDSKTLFAKYDEQGNRSWSDRKPDDFEEAAEGEETEKFAIIVRKQKPKDADSTKNLEIDSIIIQSPHLKKVLGDVFRGYPGIMTRLSRLKLKAPFECFLHRWEQFEAARDAEGQDPTAKEHLDLLYDIMKEELGDIINLRKDYFKNKSVTFDDLWTIFPPDCTVLGIKEGKPVAALFKRGSYPQTPCGQEYNLECKIIDWDGVKMGWSSLKLQIPAFLGFANFSSLPCYPIEYCSNPEAIKETLRERGRRFESLAGFCYRQHEGVAFYHPEQDADKTSRETVQGRIVVDCANWQKNNPDHALWLDNLSPSDDNNNNDDADSDDGSPNGNNCASSKADSQPQAPLTQDQLIYTSPVVRGYSLSSKRWMDFFVDNITDVQFDANAFNSLVMDPEKKEVILAFAESQARFKNAFDDVISGKGKGIIMLLCGGPGTGKTLTAESVAEEMRVPMYSMSAGDLGNDAYEVEDSLGKILKMVSNWNAVLLLDECDVFLEERTADNMERNRIVAIFLRMLEYYEGILFLTTNRVKRMDPAFHSRIHITMEYPPLDEEARAQVWRAFLERSRGEEGHDVAEGEVKRLSALDVNGRVIKNMVKAGSLLAFHRGERLGFGHLATVLRMTGHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBM4</accession>
    <name>A0A7D5ZBM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HAP2</name>
        <name evidence="8" type="ORF">G6M90_00g103100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546038.1">
        <property type="nucleotide sequence ID" value="XM_014690552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBM4"/>
    <dbReference type="GeneID" id="26240461"/>
    <dbReference type="KEGG" id="mbrn:26240461"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27591" checksum="5AC43710C696CCE0" modified="2021-02-10" version="1">MYQPQYGVPQQGMQQVPYGMPGIQAAAMAATAAASGSNYPYMHSDPSMPQTSPRMADGSKKDSRQSPRMNNMSQMPRRMSQVTSPGMPNAQGMMSHAAGRPVAPPQIPPGQAMPHPQSPEMPAGGAEESPLYVNAKQFHRILKRRVARQRLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTAEEVAAMEREAKGEDGAKVEGGDNTSDKPTESVGSKRKSEAEARSPNKKSKTDAQNSEEDAAEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBM9</accession>
    <name>A0A7D5ZBM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">arc2</name>
        <name evidence="8" type="ORF">G6M90_00g102990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546049.2">
        <property type="nucleotide sequence ID" value="XM_014690563.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBM9"/>
    <dbReference type="GeneID" id="26240472"/>
    <dbReference type="KEGG" id="mbrn:26240472"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="319" mass="36730" checksum="D90C0E38E6CD69A2" modified="2021-02-10" version="1">MLLLDYQNVLIQSVLTERFSGAPPTSIDQTVSDFDGVTFHISTPETKTKILLSIQIRCFQDLVQYGAEQVLQREYGQYVAPVEPGYDFSVLIDLENLPEEKEERDALAMKFALLKRNAMAAPFEQAYQEHYELKEQASKFTSEEAPQGVREGGQVKAIRYREEEAIYVKASHDRVTVIFSTVFREETDRVFGKVFIQEFVDARRRAIQNAPQVLFRNDPPLELQGVPGVQNTGTGEIGYVTFVLFPRHLTPQRMPIVISHIQTFRDYFHYHIKASKAYIHSRMRKRTADFLQVLRRARPDSEEKERKTASGRSFKVQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC07</accession>
    <name>A0A7D5ZC07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome complex component CSL4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Exosc1</name>
        <name evidence="6" type="ORF">G6M90_00g107090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544127.1">
        <property type="nucleotide sequence ID" value="XM_014688641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC07"/>
    <dbReference type="GeneID" id="26243514"/>
    <dbReference type="KEGG" id="mbrn:26243514"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05791">
        <property type="entry name" value="S1_CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000198">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="208" mass="22339" checksum="6E5E4A29142432C7" modified="2021-02-10" version="1">MAADELPSVAVPGHVLGPASRYTPGPGTHTHQGNVVSSLLGRVHVAAPAKAPGPAKRLNKITAAAAEELPTVSVARHGRRREILPDVNNVVLARVVRLMPKQAIVVIQQVGDTVLQTEWQGVIRVQDVRATEKDKVKMYESFKPGDIVKAQVISLGDQANYYLSTASNELGVIMAASEAGNDMVPVSWKEYRDPETGLTEPRKVAKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC18</accession>
    <name>A0A7D5ZC18_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">phd1</name>
        <name evidence="15" type="ORF">G6M90_00g109840</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543872.1">
        <property type="nucleotide sequence ID" value="XM_014688386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC18"/>
    <dbReference type="GeneID" id="26243259"/>
    <dbReference type="KEGG" id="mbrn:26243259"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000007">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
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        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF36">
        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="14">
        <location>
            <begin position="86"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="474"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="211"/>
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        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI74228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="499" mass="56151" checksum="A14A55A2D374203F" modified="2021-02-10" version="1">MDINPYRFRVPKPNYLPHKQDIDSDDVIVEEYSNAPLGLASEMDNAKFYNKCKRLAEESAITRPKGYNVSFHCNPDMEKHHFGMTHPMKPWRLTLSKSLIYSYGMSFAMDNYISRAATYEELASFHSTDYLDFLGTVLPEPVPRDLENQNPDLKFNLGGSDCPLFDGLYDYCSLSAGGALDAARKITSKQSDIAIAWGGGLHHAKKAEASGFCYINDIVIAILELLRFYPRVLYIDIDVHHGDGVEEAFFSTDRVMTASFHKYDPHNFFPGTGALDDNGPKNEHNPGAHHAVNVPLNDGITDEQYDMLFNSIIGKIVEKFRPSAIALQCGADSLAGDRLGRFNLQVQGHGACVEFCKKVGLPLILFGGGGYTPRNVARAWTYETSIAVGCQDNISPVLPQHTPWREQFRQDTLFPTLEQILGEPRQNRNPQKRLQEIVQHISEQLRFVQAAPSVQMQTIPPDLGAIRQEVEERLKEENEERNDELRRAREAAVGTPMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7G1QD77</accession>
    <name>A0A7G1QD77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase chain 1</fullName>
            <ecNumber evidence="7">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nad1</name>
        <name evidence="10" type="ORF">G6M90_mt0011</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="9"/>
    <reference evidence="9" key="1">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Kouvelis N V."/>
                <person name="Kortsinoglou A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAB3396442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="QLI74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7G1QD77"/>
    <dbReference type="OrthoDB" id="5203521at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="NADH DEHYDROGENASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432:SF3">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAB3396442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="369" mass="41238" checksum="02CFC6D0344E44D5" modified="2021-02-10" version="1">MNLPTTVISIIENLLLMLPALLVVAYVTVAERKTMASMQRRLGPNAVGYYGLLQAFADALKLILKEYVAPTQANLILFFLGPIVTLIFALLGYAVIPYGPGLALGDMELGILFMLAVSSLATYGILLAGWSANSKYAFLGSLRSTAQLISYELVLSSVLLIIIMITNSLNLNINVQFQKIIWLGIPLFVILIIFFIGAVAETNRAPFDLAEAESELVSGFMTEHAAVVFVFFFLAEYASIVIMCILTSILFLGGYLLGFDHVYFFDSINYIYAYLFNIEWITSNEYFKLRELLTSSAVDGLLYSLALGIKSSMMVFTFIWVRASFPRIRFDQLMSFCWTVLLPILFAFIILVPCLLHIFGIYFINISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPC1</accession>
    <name>A0A7D5UPC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g000070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985571.1">
        <property type="nucleotide sequence ID" value="XM_066129475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPC1"/>
    <dbReference type="GeneID" id="90967384"/>
    <dbReference type="KEGG" id="mbrn:90967384"/>
    <dbReference type="OrthoDB" id="5242174at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8321" checksum="E9171006C2C3F382" modified="2021-02-10" version="1">MFHTPGLELVPLESPKARRLPGLGLIDIVDGLINGLIPTLMDLATQGEKECRFVGQITETLLLNYDDKNVIIFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ20</accession>
    <name>A0A7D5UQ20_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase-activating protein 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARHGAP35</name>
        <name evidence="9" type="ORF">G6M90_00g021950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548357.2">
        <property type="nucleotide sequence ID" value="XM_014692871.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ20"/>
    <dbReference type="GeneID" id="26237801"/>
    <dbReference type="KEGG" id="mbrn:26237801"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="685"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123644" checksum="6F71054069649A4E" modified="2021-02-10" version="1">MTAIVDEYIESPLDNDDVFPCKGCGEILEEGKAFELAGNRWHLDCFRCHTCGTLLDSDANLLLLGDGSLICNNCTYSCSACGNKIEDLAILTGDQAFCATCFRCRNCKRKIENLRYARTSQGIFCMGCHETLMARRRKKSKAASAAKSRDKENSPMITEKSLPALPPSAIPPNAFSNDRVDPDSDTPTELSPRPRGTHRHNESSSRGSSRPSRSPERSETTSKPEGLGLPATTYRKNRNSTIYQSPNSGPEEGPESFFIPVALDPSPALTGTPRSASDNAAENGRRKDRDYFGVSKGSGSDKRDDSQSSTPHIAFQEKGRQPSSDLDVARLKSGKFTKNSEQGQRKASVSGDEFKLQDAPVKKRGVSTRSNSSHSSAPQEGSSGKTSNGVVRKDGHSNLSEARKVNEPRTSEDTDGAKSGSRSESSKAITRKELPASASMNSIGQRSSERSSRSGQSEQNNLSDSYTQPRTAPPPPPTEQAQTPRKSSGSSKDPSEPKHSPKLPRWSNGGDFSMDEDMARILGTDEGSSSILRRVSNVVRHGRTGSVEAGHPNSGRINHSRSISETTRATGSPRWPKTPMGDDHPGMPHDISSPISLTPPHDAVLLKRQLRNSEQRVAELERQFNTEKDLKSLNRKLVEKRKTVSVLDTQTEIMIRQLEVLAGYVERAKETKTPIDPRELEDSAIKDFVKKLDAVKETMSEAIEKLHEERDQLVEEKNQAIADRDRALMEFEQLSSKNAQLADMNNDLTHQIQERFKSQIGDLKSPNGLGIYGPTKSGGASSINLDTSSLNTGTTLMGDEEPIVESGPTVVQVRKGQVKKFNWKKGSKTMAQNVAKGVNRAVVAFQQTDRERMQHQGLVGDNIGLPYNMTVTQVESAAPSGLNGQNRQQQHMDPGRQGFGFFGKKNAMPKSASSNTVTLAAAAEPASILFGSDLVERTEYERRQIPAVVTRCIEEVELRGMDQEGIYRKTGGNSQVNMIKDGFDKNENFDISDPDLDITAVTSVLKQYFRKLPTPLLTFDVYERVLESNAIADETDRCSHLRKTFASMPERHGDCLEFLMFHLNRVASREPENLMSPKNLAVVFAPTIMRDLSIEREMTDMHAKNIAVQFVIENTNRIFDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQF4</accession>
    <name>A0A7D5UQF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 17">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 17">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 17">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">rnp-2</name>
        <name evidence="21" type="ORF">G6M90_00g013480</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 17">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 17"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549173.1">
        <property type="nucleotide sequence ID" value="XM_014693687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQF4"/>
    <dbReference type="GeneID" id="26238617"/>
    <dbReference type="KEGG" id="mbrn:26238617"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000275">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 17" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 17" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="19">
        <location>
            <begin position="46"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="20">
        <location>
            <begin position="245"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="18">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI64395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="392" mass="46110" checksum="00566333D86A38E4" modified="2021-02-10" version="1">MEQPADGPIQSIAEPGVKASGPLLYSMRKEVAELLGRHQTGFPGAQPVSFARQHLDELQKQDYYVCEKSDGIRYLLYSTSDEEACEAHYLIDRKNDYWFITNRNLHFPLENNTQAFHRDTLVDGELVWDSLPNGKKEPRFLVFDCLVMDGNKLMDRTLDKRLAYFKERLYTPYKKLFKEYPDELRFQPFFVEMKPFQLAYGIEMMFKQVLPSLKHGNDGLIFTCRNTAYKHGTDPHILKWKPPEENTIDFRLKLTFPLVEPDEWERKEGITEPFIDYDSVPKSELLIFLGDSGDKYELFDDLYLTEDEWETLKSLNDPLNERIIECNQDDQGRWRLLRFRDDKHEANHKSTVVSVLESINDRVSEKDLYRAAGPIRDSWKARQARSTQVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQT2</accession>
    <name>A0A7D5UQT2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g009640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549550.1">
        <property type="nucleotide sequence ID" value="XM_014694064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQT2"/>
    <dbReference type="GeneID" id="26238994"/>
    <dbReference type="KEGG" id="mbrn:26238994"/>
    <dbReference type="OrthoDB" id="4941039at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="484" mass="51344" checksum="6DCF9997272DCC21" modified="2021-02-10" version="1">MNNPLGAPAHALLPVNVKSKQRAVGKALDETIRKNNSNNSTDTQQPSTTSAAPTVAQNHKKPYSSLSSFLSSPPSTTAGRDRDKSLRPNMHLHLDPASAGVTGESSSPSSRRHSLAVSTAGHSSWSSTDSAPGLFASWRRASTSVPAGAESAPLTAADAVVGLIAASCQAQHDLEALNTSEALLKRPLGEVKSFKTTALLLHKFLRRVEAGTLAHRDRPGLMELDVLVAVLTASVLTLSELEARLEGLVMQAGELGVSVDDMVQRHSRSLAKDANRIAMLEFIMTQLLNVLHVSSSQDAARHRAQAGLAVMDMLQADAALAGRMQQLQDAAGGLGLVSPERRAEVASRPPPSYSVPSPGGGDEPPNYDQALDDDSVAIQPRDWSVYSGLNLMDIPALSSISLPLILGEIQDAYYYTEEYAHSVRDGLIALEEARNTQKSKALARVLGIEEAGGKDKDSAASDHGGLAHRLALKMARGKLLSRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR63</accession>
    <name>A0A7D5UR63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein TED1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TED1</name>
        <name evidence="3" type="ORF">G6M90_00g029210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541248.1">
        <property type="nucleotide sequence ID" value="XM_014685762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR63"/>
    <dbReference type="GeneID" id="26245883"/>
    <dbReference type="KEGG" id="mbrn:26245883"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="583" mass="66556" checksum="4FFB33E4D20096A8" modified="2021-02-10" version="1">MLARAFLRNGFGLLVPLAVACSIYLYLYPVFSRCAFPLPSRDPDAAFEETKKLHWPYADAETNAQAHALPTKQAPFRLLALGDPQLEGDTSIPTVYLGIFPHVKTIFQRLTFQIWHDSLRDRVRVILHDIIDIFFEDIPFIFESWRKRFDLFGNDFYLAHIYRTLHWWTQPTHVTVLGDLLGSQWIEDDEFERRGRRFWNRTFRGGERVPDDVAMWPNIEYNLSGILDGSAAEEVWRRRIMNVAGNHDIGYAGDLTPERIERFERVFGKANYELRFELPVTDPETNATIQDPETNPASVRLPPELRIIVLNDMNLDTPAKDQGLQDATYNFINAAIGTACAVEYKGQFTLILTHIPLYKPAGICVDSPFFDFHGDHDGGGVKEQYLLSSDASKGILEGIFGVSRDPQAAGQGMGRPGLVLNGHDHEGCDTYHFVNQTNGTTPDERSWESRKWQDVRVSNIQQLQQHPGRREITVRSMMGDFGGNAGLLSMWFNHDTWEWEHEYVDCPLGRQHFWWLTHFIIFGVILFGSSYVAVAILESKGVDVDARLRQAFVWAQQQLKELEKKRQARKNAAVSNGKPGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URH3</accession>
    <name>A0A7D5URH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027740</name>
        <name evidence="3" type="ORF">G6M90_00g027780</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985880.1">
        <property type="nucleotide sequence ID" value="XM_066129996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URH3"/>
    <dbReference type="GeneID" id="90967544"/>
    <dbReference type="KEGG" id="mbrn:90967544"/>
    <dbReference type="OrthoDB" id="4939378at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="201" mass="22805" checksum="90E88DAE8C2050A3" modified="2021-02-10" version="1">MPDSRLLPLRPAQTKQDVIIGSSDPRQSPSSSLKLVLEQANAGSSNTCRAIHALWSQDVKEVTSRMYLVEASLSASQDEMARCDEQHEEDMHKLRTKMYVLEEKVHVLQEDMLNSRQEHYDFSQELRAELHRTRERLHQITGDIQVLKDNEVRIYVSSFSWHISYLHVESPGLVEVANSSEGFDSASSPATPEAIDAWGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URP5</accession>
    <name>A0A7D5URP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinamide riboside kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrk1</name>
        <name evidence="1" type="ORF">G6M90_00g008950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985926.1">
        <property type="nucleotide sequence ID" value="XM_066129657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URP5"/>
    <dbReference type="GeneID" id="26239060"/>
    <dbReference type="KEGG" id="mbrn:26239060"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="283" mass="31337" checksum="F422E9ED94932A6C" modified="2021-02-10" version="1">MPKSLIIGISGPSSSGKTTLARLLRDIFPNTFILHQDDFYKPEPECVALPPHSPQCSHEGRLPVKNGLLDWDSAGALDISAMTEALSYIRQHASFPVLAPHRLTFCSQILTSSKPTLDSKEDQNSVGKCPVPESTITALRSRVSDALPSSHPLRGENLRLCLLDGFLLYSPSMQAVHSHLDLKLFVRASYAKAKARREARDGYVTIEGFWADPPGYVDKIVWPNYVEEHAWMFDGGDVEGTFNADVLESQGIKAPKEAPVDADLEYVLGWMVDVVIDELRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USD4</accession>
    <name>A0A7D5USD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PIN4</name>
        <name evidence="9" type="ORF">G6M90_00g014380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549084.2">
        <property type="nucleotide sequence ID" value="XM_014693598.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USD4"/>
    <dbReference type="GeneID" id="26238528"/>
    <dbReference type="KEGG" id="mbrn:26238528"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="124" mass="13345" checksum="1F16E2EAC56E77E7" modified="2021-02-10" version="1">MGKNDKKGAEKSAGKGKGADKESGGKGKGAQAINVRHILCEKHAKKEEALAKLNDGVKFDEVARNYSEDKARQGGALGWKTKGSLDPKFEEAAFALEPSTTNNPKIAEAKTEFGYHIIMVEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTF8</accession>
    <name>A0A7D5UTF8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g004660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986091.1">
        <property type="nucleotide sequence ID" value="XM_066129576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTF8"/>
    <dbReference type="GeneID" id="90967417"/>
    <dbReference type="KEGG" id="mbrn:90967417"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="11810" checksum="EF835DF3E23DE611" modified="2021-02-10" version="1">MSSHGTENGVIAVRLHEVRVRIFGGVQLKAWDTAVQDPDANEIEFDPAAAIDPAVTVNDGDRFNPPGGGLMLADSSTNIDMKRDASLKLRDPEGIGRLNKAARDAGKRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTH4</accession>
    <name>A0A7D5UTH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g002470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542833.1">
        <property type="nucleotide sequence ID" value="XM_014687347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTH4"/>
    <dbReference type="GeneID" id="26244206"/>
    <dbReference type="KEGG" id="mbrn:26244206"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="59"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="321" mass="36066" checksum="EA746F37C483156F" modified="2021-02-10" version="1">MPPSPPTYADQQAWRDIQAYLPSRLHFTPEHSPVEEFWSHRGHTLHLDRWPNPSSKVRLILHHGVGTNGRQMSLLLGVPLHTAGFDLVAIDMPGYGCTRVSPQNKNYPYDEWVQIASDLIDREMRDDPRPIVLYGLSAGGMLTYHAAAKNKRVRGIIGMTFLDMRIQQVVDATARNIVMSRAGIPLAKVANAAGLPWFRLPMSWASKMYALVNDAAALRVFLKDKSSAGAMASVRFLATYAGYRPALEYEDFDVCPVLLTQPADDRWTPLRLSELVLGRVKKVPVRIVELEGAGHYPLEDRGLQQMVDAIIEFLREVEQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTL8</accession>
    <name>A0A7D5UTL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ALP_1</name>
        <name evidence="10" type="ORF">G6M90_00g040970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547444.1">
        <property type="nucleotide sequence ID" value="XM_014691958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTL8"/>
    <dbReference type="GeneID" id="26240007"/>
    <dbReference type="KEGG" id="mbrn:26240007"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028934504" evidence="7">
        <location>
            <begin position="21"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="148"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="367" mass="39772" checksum="2284DA3362A5F321" modified="2021-02-10" version="1">MFSFKTLASLLVAALPLGNATPQAGSAANLVPDKYIVTLKDGISANDFNFHLNWVRDVQVARAGRRRGLNFRGVEKTYGVGNFNAYAGHFDEHTLEAIRRNADVESVEQQQVYHLHELTTQKDSTHGLATVSHREPGATEYVYDSSAGEGSTVYVLDSGIQVDHPEFEGRAFRGYNAVKDATDEDVQGHGTHVAGIVGSKTYGVAKKTKLVDVKMFHDAGSTNAIILDGIEWTIKDITAKQIQNRTVVNMSFGGGNSTALNKIIKTAYDAGILCVISSGNMGVDASDWSPASSPDGITVGAIDANWRLWDHSNHGPVVHILAPGVDVLSLAPGNRLREGAELLRRLLMLLGWPPIWQLLKTSTLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTN2</accession>
    <name>A0A7D5UTN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">rpc2</name>
        <name evidence="22" type="ORF">G6M90_00g035100</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546904.1">
        <property type="nucleotide sequence ID" value="XM_014691418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTN2"/>
    <dbReference type="GeneID" id="26239467"/>
    <dbReference type="KEGG" id="mbrn:26239467"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="43"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="193"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="455"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="557"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="639"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="686"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1064"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QLI66794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1157" mass="130898" checksum="69AD28094AF50CE3" modified="2021-02-10" version="1">MPLVDDGFEALLEPFYNGKKLTDPVNTRDDKFQLLPAFLKVKGLVKQHIDSYNFFVEQEIKDIVRANRTIRSDVDSNFWLEFTDIRVDRPRRQDHNDAKSRTEVTPMECRLRDMTYAAPIVVDIAYIRDKQRIIRRNVPLGRMPVMLKSSRCRLSGANNAQMEAMNECPLDPGGYFVINGTEKVILIQEQLSKNRVIVEADEKNNIISASVTSSTHERKSKTYVTLKKDRIVMTHNVLVEGIPIVIILKALGGLSDYEIMQLVAGSDGRYQDEFVINFDEATRAGVFTQHQALEYIGARVKMGSRKAMFGPQVRRNNVEEGLDALANLIIAHVPIEGLDFYPKAIYVAMMTRRVLMASQDSKLVDDRDFVGNKRLELAGQLLSLLFEDLFKRFMGEVKMSIDKFLKKNNRAVPLDAVHMISNHANNIGMGINRAIQTGNWSVKRFNMNRAGVTHVLSRLSYISALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTNVDEAPVKRWIFTLDTGVEPIRNFSGAEMHREGSWVIHVNGTPFALTRYPKRFASRFRTMRRKGWISPFVSINLNSHFNAVHIATDEGRICRPYIIVKNGKQKLRHEHLKLLHLGKVTFDDFLTKGIVEYLDVNEEQDALITLYENQITQSTTHLEIEPFTLLGAVAGLIPFPHHNQSPRNTYQCAMGKQAIGAIAYNQFNRIDTLLYTLVYPQRPMVITKTIQLVHYDKLPAGQNATVVVMSYSGYDIEDALVLNKASIDRGFGRCQVFRKYTTELQKYPNGRRERIGDPVNQVNGGTTRREVKYEALDDDGLATVGYRVRSGEVMVKKETPLDLTTTGIGLDRGPSEYRDSAISYRIPDPAYIDKVMISQTEKDTTVIKVQTRQTRRPELGDKFSSRHGQKGVVGIIVDQEDMPFADNGLCPDIIMNPHGFPSRMTVGKLLECLTGKASIIDGRPDYGFGDAFRSHPVKDMSQVLLDYGFSWEGKDYFTSGLTGEPLEAYIFNGPIYYQRLKHMVQDKMHSRSRGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMLSSDGVTLDICQQCGLFGYKGYCNTCKSTRQVTQMQMPYAAKLLVQELISMNVGVRLQLEDEFPHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTV0</accession>
    <name>A0A7D5UTV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545143.1">
        <property type="nucleotide sequence ID" value="XM_014689657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTV0"/>
    <dbReference type="GeneID" id="26242484"/>
    <dbReference type="KEGG" id="mbrn:26242484"/>
    <dbReference type="OrthoDB" id="3535343at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028900117" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="205" mass="22800" checksum="6D42422FB86C017C" modified="2021-02-10" version="1">MYISNIALLASATAVAANCPSFPSSLVEYSSEFKQPTPPAVKPEFQTHFVQHKWNQNLSHIQTGYMYNSPAKNLVRVDETFEDGLATSVFNFANVTEDARVDNTLTSVFKDFAHPQVWRGYVNTNYPLIGADFLAKAGAVFSGLVERDFIPGRVASWSIMYQGAIPVTVYVDGCNVVQGYDYFAPIERTRVTTSFFNTRVGKVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTV4</accession>
    <name>A0A7D5UTV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g049850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545092.2">
        <property type="nucleotide sequence ID" value="XM_014689606.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTV4"/>
    <dbReference type="GeneID" id="26242433"/>
    <dbReference type="KEGG" id="mbrn:26242433"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="626" mass="70231" checksum="01376CA6F657AB1A" modified="2021-02-10" version="1">MGCAGPPWSLVTMQCPSPVLLEALIDVYFDRMHWFTLVFHEPSFRQAAKHVLSRTSWHRDELGFVLACLMVSAVGLKCVVRDPSWIGHAMLAEESWDAVTLLEALIKEVRFHLLDLLDDCSIETVQVCSLLGTYYVFHASPTLAWSILGMAVRTAYALTLHCDGDDDSATGKDYDPVVAQVRRRNWNHILVADTFAAMIYGRPVSLDAAFSYVQPLDDLDDLVLGPGLSKHPLLTANSPRSVSSRPVSRQTFHELKYYLYDIVREALNRFRLLRLQSPISPAELVSLVEAVQHVRSLLYAWKADLPAVFDTNPTSQEAILADLDSIPDLSPEEQKSRRHLSLQINALNVTYNSAVIFIHRPLLEYRVAADSRQALSSETLQVVSESLQLSVNAALEMSRVPVPHLENQFAMSFVLMNFFTAGVILCIPPTTWPLSSIAHEAKAGTLRIIHASRALKPVTPIASHTEQLLTGLLRRSLQQEVDSGLHQEHNVRIESDRRYPASMDQTMRYSQQNHLPIQNETEARNEQANQVPVQQAPRFSQADRQGPISGDQMRMANVSLFPLTHNGEMEDANVMHSASTIYDENGNLVISNNDPRRGAIDYHYAEQRHQVDSQLDEVFGIFGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUF8</accession>
    <name>A0A7D5UUF8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trafficking protein particle complex subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trappc13</name>
        <name evidence="3" type="ORF">G6M90_00g049930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545100.1">
        <property type="nucleotide sequence ID" value="XM_014689614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUF8"/>
    <dbReference type="GeneID" id="26242441"/>
    <dbReference type="KEGG" id="mbrn:26242441"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="2">
        <location>
            <begin position="214"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="34790" checksum="1E2313D441156B46" modified="2021-02-10" version="1">MSHQRYPSHDPVKEPHSVSVKVLRLSRPALVPQYPSSPLPATKEAFLPSSLSYKTPSTNPAPFLLSPILNLPVSFGSAYVGETFSCTLCANNDLTTTSSSSSSPSPSPPPAKHIRDVRIDAEMKTPGPGPAHRLPLASGAPADLAAGETLQRVVSFDLKEEGNHVLAVTVSYYEASETSGRTRTFRKLYQFMCKAGLVVRTKVGLLGGGSSSSSRKRWVLEAQLENCSQDVMQLEEVGMEAERGLRCEGCNWAEGERPVLHPGEVEQVCFVVVEEDEEDEDEDGSGADGDADGRVVFGVLGIGWRGEMGNRGFLSTGKLGTRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUF9</accession>
    <name>A0A7D5UUF9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc-regulated transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZRT1_0</name>
        <name evidence="8" type="ORF">G6M90_00g043310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986229.1">
        <property type="nucleotide sequence ID" value="XM_066130320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUF9"/>
    <dbReference type="GeneID" id="26240229"/>
    <dbReference type="KEGG" id="mbrn:26240229"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028845793" evidence="7">
        <location>
            <begin position="19"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="487" mass="51312" checksum="39B8FEA5156C25DC" modified="2021-02-10" version="1">MHVSSSLAGLALLGAATANNIYPRQTAAPSPTSAAAPQITAVTDCHLHGSQVFCLAGATEYLVHTTPTQTTDIPAQFTGCHSHGAETFCIAPNGDDVQVNVPGAEGDAHQGGDQHGSDSKDSGHQHCHFHAGVEHCVGGDESENAAPKCDTTPRDYNIGLRVGLLFVIMASSALGVFGPIFLHRVLPRRLSTIFTLLKQFGTGIIISTAFVHLFTHASLMFGNKCIGELGYEGTTAAILMAGIFLSFLVEYIGHRIVLAKTRSTALLTREKQAEALLSTEVVSILVMEAGILFHSLLIGLTLVVAGDSFFITLFIVILFHQVFEGLALGTRIATIGSSADVHLLPPAVNHSDRAVENDTDKSVNSPTEETADASSTFEPPTLSMKKKLGLASLFAFVTPIGMAIGIGVLQKFNGNDRSTLLAIGTLDALSAGILVWTGVVEMWAADWMTGSHGHKAELADADMLTVGLGLFGLVAGMVLMSFLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUL2</accession>
    <name>A0A7D5UUL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 snRNP-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">US107</name>
        <name evidence="3" type="ORF">G6M90_00g035740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546969.1">
        <property type="nucleotide sequence ID" value="XM_014691483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUL2"/>
    <dbReference type="GeneID" id="26239532"/>
    <dbReference type="KEGG" id="mbrn:26239532"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="269" mass="30440" checksum="1713F60939A08FAE" modified="2021-02-10" version="1">MAAEQRKLLEQLMGHQSTSRAAQLSLTDPKVCRSYLVGTCPHDLFTNTKQDLGQCPKVHSEPLKVEYEALSDREKQRYGFDYDYMRDLQKYIDDCNRRIDAAQKRLEKTPDEIRQTNVLLKTISELAASIANGQLEVEVLASMNEVSRAVDENFRIKQTMQLKVEKEKELKALSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYASMRKTYDAFPRELKSRQRQGMMDGDDGPGGGMGGPRGPRAGGYRSGRGGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVD4</accession>
    <name>A0A7D5UVD4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g031800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986474.1">
        <property type="nucleotide sequence ID" value="XM_066130093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVD4"/>
    <dbReference type="GeneID" id="90967592"/>
    <dbReference type="KEGG" id="mbrn:90967592"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="90" mass="10187" checksum="7AAEA0396DC53A08" modified="2021-02-10" version="1">MTHVRDFQFWEKAETTMISDTNSGEIDALWSSKRPRGSSATARPVSYPEVAPFKDSRSLEGEFDILEIAKMGWMLSVDLRGLELFVSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVQ8</accession>
    <name>A0A7D5UVQ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Hybrid PKS-NRPS synthetase lepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">lepA</name>
        <name evidence="15" type="ORF">G6M90_00g052060</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539400.1">
        <property type="nucleotide sequence ID" value="XM_014683914.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247800"/>
    <dbReference type="KEGG" id="mbrn:26247800"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="2"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="14">
        <location>
            <begin position="945"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="2389"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="12">
        <location>
            <begin position="3541"/>
            <end position="3620"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="10">
        <location>
            <begin position="945"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2470"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2472"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2504"/>
            <end position="2541"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="10">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="10">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="3627" mass="398213" checksum="2CB7AB8A4DF59B29" modified="2021-02-10" version="1">MYEPVAIVGTACRFPGAANSPSRLWDLLKEPRDVVKDFPLERLNMVNFYNENGETHGRTNVHHKSYLLEEDVRHFDAAFFRINPKEAADMDPQQRILLETVYESFESAGWSLNHVDGSPTSVHVGVMTDDYTLISSRDPDMLGSHAATGLSRAILSNRISYAFNLQGPSLTLDTACSSSLVALHLAIQGLHSGEAVQAVVAGTNLLMDTIWYIAESSMHMLSSDSHSCMWDKDASGYARGEGCAAVVLKPLSKAIADGDNIECVIRATGVNSDGRSNGITMPTPTAQAALIRETYGVAGLDPITDRCQYFECHGTGTQAGDPVEAQAIRDAFFPNGQHKEHDILYCGSIKTIIGHLEGCAGLAGLIKASLAIQNKAIPPNLHFHQLNPRVEPFYNNLEIPTSLLPWPETHSQPRRASINSFGFGGTNAHAILESYEPSDAASPSPLSSSVHTTMVGGRLVGPFVFSARTPSSLLKSLKKLLGHLRANSSLDLDSLSNSLHSKRSVFPYRVTIPSALDRDDLIQRLEDQVNTVATSTLSPLGGGTGDEPRILGVFTGQGAQAPRMGYALLQHCKLFQDSIRQCDLALKLIPDPPEWSLAEELAADAATSRASQAKFSQPLCTAVQIGLVDLLRASGIRFCAVVGHSSGEIGAAYAAGLLTRRDAMGISYYRGHVAHLAQGNGGRSGGMMAVATSLDDAMALCSEQQFKGRITIAASNSPSSTTLSGDADAVVEAKRVLDERNIQARVLQVDTAYHSHQMLACVDAYAAHLKQLNVRVLTPASDDDCPWYSSVKTNTDILANPPQFGLEGQYWLDNMVQPVYFSEAVKLAVQDASTKFSAAIEVGPHPALRGPLKQTLTQSIDYTPHYAPLLSRDGDSIETFAEALAALWTISPSSIDFGGWRRAFGLVAQPQTIKNLPPYSWDHTQIHWRESRVVQNYRLGKQLPHDLLGRLWNDSQYEQVWRNIFLLHEMPWLKGHVFQNQVLFPATGYISLAVDAAKAFVKGRAIKLIQVEDLLITTALAIGERDEVEVLFIIRSHVSPQNVEAGCVLEAEFACYSYPDQRDADRTCHGRLRIHLGEFESADLAPVCISEVNLTPFNIDRFYGAASEMGFQYQGPFRGLTLLNRCWGHAKAGASWSIEDLNIDCTLHPAILDVALQAGLSTFLSAAENSMASSYLPVGIKRVVVNPNERFRGPNRSTNVDIEAYMVSRGIGKLMEIDINLRDQMSPHGDVCGIQMEGVSFKAISDPQPSDDRNILAKTVWGLDVAYGLIHPLADAVPLGPPLYTLENYERVALFYLQSLAHSVNKQELERLKPQHQQLIYYINAIMTKVRTGDQSHLRREWLEDDSATIEDVLSRYPGDVDMAMLKVNGEKSISLLRGDYESTNEVLEMSSKSSYQDTQSFVLCIQFISQLVRQVSHKFPRTNVLEICTGTGSAAASVFDAIGDAYESYTCAGSSETVLSRLKESLVPTDLNKIGSFRHVDFETDLTFQEDDLGLYDVVIVTGLLRASPTLAQVVQNLRRVLRPGGFLISMALTGASLRPIALMGGLENWSRGSNSRATDGYAVKTGDLDKLLHRSGFSGIDCILHDQPDSRMHGVSVFSAQAVDDRFEILRDPLLAMGMIPPNPVTIIGGETSRVSSLIRGIDKLLRAWAPEIQAYGRFDEVDMSRIQPASSVIVLQELDRPLFSSFPTENEMENLKEVLGTCKNTLWVTSGRLVDDPYANIMIGIGRSLRLELTHVSLQFLDFDAQDEWDVHALVRQFLRLVFSSSSPDTTEGMLWKEEPEVVIKDSHMIVDRIVVNDESNEIYNSGRRRVVKLVGPDEPIETAQDADSPESQLVCSRGIDILEGDMPVHVKLSVALHSESKFPCFLSYGQLKYAQETVLTLSRKDASIASIGNKSIARSSLAQNCDATTLVNLASCLIASQIVSRMLSDGTTLVCGASQELARVTSSLAARSGRKVLFVKVTSKQQSERAEWISIHPHQSTRSIHKLIPSDTAALFDLSQTDTKVVLPYLPASCTIQGFDTRSVTQQSVEEAIDIYQMQQDVFRTASTPTIVDIKDVPQRRNANPGHLSAVTRWDREAQIGVTRQPLDPSTLISPNKTYFLVGMASDLGQSLTYFLVRGGARYIVLSSRNPKEQPWVKDLRRDGIDIRVVKMDVTDRSQVRETVSLLRRTMPQIGGVTNAALVLEPGVFANLSAESIGKQLQPKVSGTAHLDDEFRTDKLDFFMAFGSLLTVCGNAGQPMYHAGNTFMMSMVRNRRRRGLAASILNFGMLVDVGYVARSDRSGSSNVEEWLRSFVPTALSEADFHHVILQGIVEGNPATGSGEVIMGLETFTDRGQAVRPSWVDSAFLSHMVRVSKSIGKETIDKAPASTQQWELDLENSSSVDEAIPPITELLSAKIESMIHVSLHSIHPDEPLSHLGIDSINAIAIRKWFREKMAVDISMLKIFGRDSSSSIIRTVAEQYLDKKSTQNAEPANVKTQPTPQGEVRSESATLMPKATLTGETQLNTSAMSTPTTNSIKNEASPTSYQQSTTESSIVTPEPELEYLQSESLSYAQSGWFYLNTISEMPSSFNLTVKINIKGQLSINRFSRAFDATMLHYDALQTCFLASAESSEPRQHVIKRKRQSRLTLLHSTAETGAADVKKAFEETAKHEYDLSIGDTLHATLISHGEQSHTLVLGFHNIAIDAFSMAHLMGDIGRAYQFAPLSPNPTSYLDFARQQFDDIRSGRFVDSFEYWKKLLNPAPEPLPLLPLAKVKTRRRQRAYGHHYIETVLDGDLVQRIDKVIQYHHVTPMQFYLSALHVLLCRLLNVDDLCIGVVFNGRDPTSKFGGTVGHLADVLPLRSKGVLGKSFSSVLKDTAQTLLDCLDNANIPFAAILEKMRPETSEGNMPMFQIAYDYRGVEESRLSPMGGCTLTLGELNYTTLYDMTVDVLHTASGDHVLNMRLSDDFYSIEATQFMMETFINVLETISQEPTASVKDYKLFSNAQIQQAATAAQGSELQYSWPNSLCERFYQVATSFPKSVAVKHGSETITYCQLRAKAGLYARILIEANITKGSRVAVHCEPSIEFYAVMLAVFHVGAVFVPLDVSLPAARRQTILRACNPDVLVFHRATAASAIAETADHVIKSFDITKLARDRQQDSPIPKRVPCEAESDSCILFTSGSTGAPKGIRLHQRALMMYAEFASRTHGFGQITVLQQTSFGFDLSLAQIYSAFTNGGMLVVAPVEARGDPDMLSRLMVDEKIEYTMCTPSEYGLLLTYADAALRQCHSWRFAGTAGEALPQLVVDGIRGLKLPNLTLTDCYGPTEAFIVTCRDIPVRAAATYDKSEDQNGCVGHALPNTSIYITSEQDGSLLPQGMAGEICIGGAGVANGYLSPEMSDAKFVKNPFATAKQVDARFSTMYKSGDRGILHPDGSVIFLGRTRGGNAVVKLRGLRVDLGEVAGAVLEAAPNDLINAAVTVRGDAQLLVCHVVFRHGKTLSNEQLTQLVRTMTLPRYMIPSAIVPLERLPMTPNGKLDTAALEALPLPLLSRQEQGEADMTETEAILRNLWINVIGEVAESADIGPSSSFFLIGGNSLHLVNLQYAIRARIGVKVHLRILEQAVDLRAMANIVNKTSRVRFAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWG5</accession>
    <name>A0A7D5UWG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="10">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">lad1</name>
        <name evidence="15" type="ORF">G6M90_00g059420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="10"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544513.1">
        <property type="nucleotide sequence ID" value="XM_014689027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWG5"/>
    <dbReference type="GeneID" id="26242925"/>
    <dbReference type="KEGG" id="mbrn:26242925"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="195"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="368" mass="39071" checksum="9D5507779816FB2E" modified="2021-02-10" version="1">MPPAATGGLSLKPNIGVYTNPKHDLWISEAEPTARSVTAGSDLKPGEVTIAIRSTGICGSDVHFWHAGCIGPMIVEGDHILGHESAGDVIAVHPSVTSLKVGDRVAVEPNIICNACEPCLTGHYNGCENVAFLSTPPVPGLLRRYVNHPAVWCHKIGDMSYENGSLLEPLSVALAGMQRAKMQLGDAVLVCGAGPIGLVTLLCCAAGGASPLVITDISESRLAFAKELCPRVITHKIEPGSAEDTAKAIVKAFNGVEPALTMECTGVESSISAAIWATKFGGKVFIIGVGKNEINIPFMRASVREVDIQLQYRYSNTWPRAIRLVESGVIDLSRLVTHRFPLEDALKAFETSADPKSGAIKVQIQSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWK0</accession>
    <name>A0A7D5UWK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-reducing polyketide synthase fsr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FSR1_0</name>
        <name evidence="2" type="ORF">G6M90_00g030050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986578.1">
        <property type="nucleotide sequence ID" value="XM_066130051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWK0"/>
    <dbReference type="GeneID" id="26247476"/>
    <dbReference type="KEGG" id="mbrn:26247476"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="390" mass="43902" checksum="F7234B86B4B08533" modified="2021-02-10" version="1">MLTKASFAIEFGPHPVVSGMIRATLGFDITVLPTFRRNTDPWEVLTKSLCSLKVIDLPAYNWDLKSFWIPDRNDWTLTKGDIPVHQCRVAAELDKSIPSTSSFNIAQSAIVETPKLKSSAIHEVLEERITSNGYEVVTECDVNRADVRPFIRGHTVDGFSLCTPERGSEIGQLSTFSMKFINKSDSQDFSQKLPNMLEHLERMRRQLTEGKTCRFSGPMAYGLVSALAEFSLDHYCVDEALYDNELYECIQVVSFGQMKKGGIFHINPGLIDGLTQLGGFTMNANDKTKLDTTVLANHDWKNLQLFEAIGDGCQYFAHVRMTPGDKVLWEGDVTIFTDDRIVGLVEGIQEVPRRLLKFILTQAAKPPKFKTKSAKETRSIPSRREEELLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWK7</accession>
    <name>A0A7D5UWK7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LYS4_0</name>
        <name evidence="20" type="ORF">G6M90_00g032630</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986392.1">
        <property type="nucleotide sequence ID" value="XM_066130115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWK7"/>
    <dbReference type="GeneID" id="26243995"/>
    <dbReference type="KEGG" id="mbrn:26243995"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="18">
        <location>
            <begin position="117"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="19">
        <location>
            <begin position="607"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI67512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="807" mass="87463" checksum="AE532F4BCD776A29" modified="2021-02-10" version="1">MPPNLGVSQMKLSATSKSAFPWTRDSYLPVLTPSIEHKPCQLLATSTHDGPTSPQCRAYIARLRSPSIATPQLRLYTSTVPPRQQAFHSQLESIPDAHILQSFQKAAAPTNPQNLTEKIFQRHSIGLAPGKTVKAGDFISIKPHRCMTHDNSYPVATKAMNLGLTKIHDGSQVVMALDHDVQNKSESNKRKYALIEEFARKHGTFFYPAGFGIGHQVMIDEGHAWPGTLCVASDSHSPIYGGIGCLGTPVVRTDAAAIWATGSTWLQHPPVAKVTFTGLLPFGVTGKDVILSLCSLFGSDDVLNHCVEFAGSEQTMASIPIDDRLSISNMCGLFPVDETLISWYRAKATAAAVCDSPAKERFNHERVKDMAENRLVADPGASYAKEFYINLSTLSPWVSGPNSPKIANPLKNLEAQNIKIDKAYLVSCTNSRASDIAAAARVFREAAKDGQPAKIASGVRFYLAAASLSEQQIAEEAGDWKVLLDAGATQLPASCGPCIGLGTGLLEEGETGISASNRNYPGRMGSKDSKAYLASPEVVAASALKGRIAGPGWYQQPDGVEKVIIGEGSGDFAADQARSIESAFDKMINEVDSMIAIAENGQDETTTTAAKDEALTDILPGFPEKIEGEIVFLDNDNINTDGIYPGKYTYQDNLPKEKMAAVCMENYDTEFTKLTKPGDVLVTGFNFGCGSSREQAATAILARDIPLVIAGSLGNIFSRNGINNALVCLEMPRLVEHLRKSFKDDAERPLTRRTGWKLLWDVRRSKAVITEKDGTVWEEKVSELPPSVQEIISFKGLENWVKSKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWQ3</accession>
    <name>A0A7D5UWQ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g051360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539821.1">
        <property type="nucleotide sequence ID" value="XM_014684335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWQ3"/>
    <dbReference type="GeneID" id="26247376"/>
    <dbReference type="KEGG" id="mbrn:26247376"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="457"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="637" mass="67414" checksum="03B3E2FE33CE7105" modified="2021-02-10" version="1">MAQPQSQVPPRAFSPPQHSPSPAGSQPGFALPPNKRVRTDGGPASQPGSPYAISPYAASPGAAGSPPLNAASPTFSQSTPMSSGYNTPYTNGHTAPALNLPDARAGASTPPLNTPHPPPPPISIPQYTNAAMAPMPQAMASPAPLPNVMGPPQRPAERPTKDYEYDVTDSLAGTGIDLRAEEQYMSELYSNAMDANSEARTGFAQHPAAGKSSFYGAGPANQAPETASEQNQKQLAAKAAEQAWADSSMRLAVQRTQEINDPFLLVAILHRRAEKIAKENHISLNLDMKNNAQTMGKMRLPEQFPTPKVTVKVEPGPDSAMVHTTGSYIPHDSYLVDQLALMSIATKQRLREMVEDAGVVATNRQKTSHGEIPEEWTAAAAPMNAETLGAAEPTSTTEEGEDGVAVPSDTAPLKRSADGAGLGNGAKPPKKLSKISSFMTLTMRELARQEREWEEARLRRRQKRKDGVGDAATPSRSGSMAPGTPGSVAPESDKPMTKKEMKKSQALKAAEANSHANQNLTSSMFAGLGGKSSLFGKKKGAKTYDWMNVGRGGSGASTPTKAAAGGGKGINGTPGAISAANVAMTTEGRNRLGTWREDKEKGKNIQLRDWVVVLERDGRESKALQQAYIHLDASNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWR7</accession>
    <name>A0A7D5UWR7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g056580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544249.1">
        <property type="nucleotide sequence ID" value="XM_014688763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWR7"/>
    <dbReference type="GeneID" id="26242661"/>
    <dbReference type="KEGG" id="mbrn:26242661"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="526"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="920" mass="99635" checksum="91569F8A32F7691F" modified="2021-02-10" version="1">MIPRKRQRPNPAEASSISLPTTALSRETATSLSQSLSMHAPSPAAKAPQPAPQPDHPDHPRRPRQPAASEAEAASTRLNVLVGPQLLPSLPPSIPPMPPSQSTHPHGAPPTHPLAQKQVRKAKSWYGPWPKTPRKATALTSVARENILGGTVRSAAAPNLDRFDSSKKSAAETASIRGDSRSVFLSKVFEDQMPAVATDTATVDDNAQHEETSIPQPPHTPKDIHATKDRNDTKEDEVIKPQAETSNSPTAPPAASAAPPPPSGWLVWWTKTPTTEQQTVTVTSTTLDNTDNPTPENRPFTPPEQTAPPDSVPREPPPSAPTVSSTWRFGFWSSTNNKMDKTDPEKEGKVEGAQPKEQQDIAMEDAPAPAAAPENEPSPKAGSTWAFWSRASPSKSSSKISSSGSGEMAVIGEGSEAHPKQMSEVDVSSPQSKASKQETQAREAQPQAKSTWRRTKRVRPSSIEAATDSDASTATRTATPVIEEPQGLPPPPKEPKPPAPSTKAESSSKSAAEAESVAKQPPNLLLPSFTSTYQMKENPSILQQITQLLLRTSQPPANHVFRVKDPPKIRKAIAIGIHGLFPATYLRPMIGQPTGTSLRFANLCAEAIRRWTDAHGSPDCEIEKVALEGEGRISDRVDNLWKLMLNWIDHIRRADFIILACHSQGVPVSIMLLEKLIDMGIITNAKIGVCAMAGVALGPFPDYKSSILMGSAAELWEFGNPQSTNSQRFEASLKRVLDHGARVTFIGSIDDQLVPMESAVYSPASHPYIYRAVFIDGRIHAPDFIAHLVGFALKLRNLGVTDHGLVRELSVALAGSLYSGEGHSRLYYDPAVYDLAICHALETTSTPSPVTCEVGPRGGLASANPYVLPWIMRGMLEESFVKTELSSETEDLLQQFDDWKPSNKALKDVKYRLEAVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWX3</accession>
    <name>A0A7D5UWX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g054110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540993.1">
        <property type="nucleotide sequence ID" value="XM_014685507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWX3"/>
    <dbReference type="GeneID" id="26246299"/>
    <dbReference type="KEGG" id="mbrn:26246299"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="307" mass="34776" checksum="D3682B4D1281BD8D" modified="2021-02-10" version="1">MQADDIILLTLAAGKQMSYLLPLLYGKCRLRLSVHKDSEKELLEKKYPGSEVVKGDMERAEDVSSMLSGVTTVIYIGPTFHPRETEIGYSMIDAAASEAQNGKLKHFIYSSVLHSQLRKLMNHDCKRYVEEYLMESGLNYTILQPTHMLDPFPVEDLMRQEQPVWHADYDPKVTFSFTVLRDLADAFAVVALEREKHYLAEYPISSTGAVSHVAVVEALSKEIGKEIAIKQKGYYEAVGGLHGLLVRANGRLDQRVSRDITDRLILYYNTYGLKGNTNVLQWLIGRKPTSIEEFFHDKVSSIRQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXN8</accession>
    <name>A0A7D5UXN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g055320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540878.1">
        <property type="nucleotide sequence ID" value="XM_014685392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXN8"/>
    <dbReference type="GeneID" id="26246184"/>
    <dbReference type="KEGG" id="mbrn:26246184"/>
    <dbReference type="OrthoDB" id="4931938at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029008922" evidence="1">
        <location>
            <begin position="20"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="294" mass="32931" checksum="56F073BD0D4E878C" modified="2021-02-10" version="1">MRYMSALFLSAILRGFVSGQDVDETKPAPPEAAAYEIRIPIGNISSHPSGTTPLGSSGIFDVLTSKSWSRNSNLAAQYYQDGTVHNWLRNEEKPKMSIIKVCGNYFYAPNIYWKGGLTGKHLHQDNKRNQKQFYAGVTQATHEVNGEFVTRDKPIEIMTERTSSACGSISFSWKSKGNWGRLGDIMDHFLRIWFAPQDTCAVSPSHGGGNGLLCALPCDPISPMWFQSTNLYVRQTRWVNGKQLYSSVYKLRGQFNSGDGNGGLKNPTWLNAQCDGDRLYFKDTPNDATYVVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXS7</accession>
    <name>A0A7D5UXS7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Epidermal growth factor receptor-like transmembrane-juxtamembrane segment domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g060960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542772.1">
        <property type="nucleotide sequence ID" value="XM_014687286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXS7"/>
    <dbReference type="GeneID" id="26244721"/>
    <dbReference type="KEGG" id="mbrn:26244721"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF27">
        <property type="entry name" value="CHITIN-BINDING TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Epidermal growth factor receptor-like transmembrane-juxtamembrane segment" evidence="10">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="195" mass="20827" checksum="05D8004D593BB036" modified="2021-02-10" version="1">MSSIQFLLGNFLRGQEQYTLLCEADAITTPIYYIYLTTDTSSTTSTTTSEAPSPTSTTTPEPPSSTPVGAIVGGVVGGIDGLAIISLLVFFLLRRRKKKISTPQQPFMSEYSPDYNRASQCSSSAAFDQRSSVAATTTGASSAFERQQGLGGSSMSTPPVAFYPSDVTGMQPQYQGTQDMSPSDKPSRLHEMFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXW7</accession>
    <name>A0A7D5UXW7_9HYPO</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688949.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXW7"/>
    <dbReference type="GeneID" id="26242847"/>
    <dbReference type="KEGG" id="mbrn:26242847"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FBXO28"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="633" mass="70577" checksum="1B14721CF4C57BC0" modified="2021-02-10" version="1">MASSGNPSRWDELPDELLLQILSYLEPYHVTKLQLVCRRLRELCLDDELWKLLSFENSQWYQSLQNRRSSFRPLAERHRDTSHHDAMQIDGDAGFSPTNAIYQDDFSTTCSLTSRPRKLQDMANWDPVFPGERVSWYDEYVQRHGPTCVNWLQTPRLYDGGVEATIEARGMALYSPHDGSDGVGTMLAVSPLDDGSVCLWDINGTRGRQGGILAASNPGILFNDGPGDQNSKRSKKIDTGVTECVSVDNHGHRAFFAVQSHLIEVDLNRLEVVSRESFEWSITTLSALHQGVPLTVGTSLGVHLHDFRMRAMASRDIVERLDVIQWDESNVFKMIFDTKPLPPYASLSQPTPISILHLPRPGSHNLVSDDIYVAGRFSNILHYDRRKFPAIEGSIYSGALIKSLAALPYPFSAVDTEVRRQGDLTTEQVAQLKSEGEGRTLIAVGGYNSKGSLEIYGLSSAAGGGERSILQNSVTKNRQTVASSTILSVANHGSKIVFSDGSGFIKWFERDGSTECRRMRIGHSDAEEASSLFASMAGSDDMARKIVSTKSNQGNDRPNNDNILLWTGEKLGLVSFTKSPIFDGKDFELQGPETSVENERRKEYTHRMRRALERQADEVKFIGRLGDPASWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY44</accession>
    <name>A0A7D5UY44_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucose 4-epimerase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UGE2</name>
        <name evidence="6" type="ORF">G6M90_00g055850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986866.1">
        <property type="nucleotide sequence ID" value="XM_066130609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY44"/>
    <dbReference type="GeneID" id="26242590"/>
    <dbReference type="KEGG" id="mbrn:26242590"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="446" mass="47534" checksum="156ADFFF76F780F9" modified="2021-02-10" version="1">MESSESSPGTPSRDSADSPPTVATWTTSPDVSLLDVSLDDGSGASPAASLSARREEYVLVTGGLGFIGSHTVVELVKAGYNVIIVDDLSNSYRSVLDGILEIARRHYEDRRQGGGARRRCPMVEMHQVSYRDLPAMRSILELHSFPSPAGTPARSNIVGVIHLAAYKAVEESIRHPLRYYQNNINGLVDLVALLGEFAVKTFIFSSSAAVYGSLSAGGGRPLREEICAHPAERAGTGAPPSRSAGGGGITNPYGRTKLFAEAILSDVAAADASWRVVVLRYFNPVGCDASGLLADNPRGLPSNLVPVVTQVMTGQRAGLDIYGGDWDTRDGTAVRDFIHVSDLARGHTAALEACRDGRVDASYRTYNLGTGEGSSVLDVVRAMEAVSGRAIPRETVARRDGDVAASVAAVDRARRELCWETEKTLLDACYSVCSRLDLLPCRARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY71</accession>
    <name>A0A7D5UY71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g064860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540058.1">
        <property type="nucleotide sequence ID" value="XM_014684572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY71"/>
    <dbReference type="GeneID" id="26247094"/>
    <dbReference type="KEGG" id="mbrn:26247094"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="306" mass="33646" checksum="42CC1728F415395B" modified="2021-02-10" version="1">MATYLVTQATGEQGKWVIKHLLAASVKVHAVVRDLQKVPPILKNPGVTLFQGESRNFDEIYQAAQGCTAAFLNTFPIPGLEALQAKTIVDACRKAGVETLVASTTFTVGDRASWDHEKTDECQLREYFVSKAEVEDTVRRAGFRAYTILRPAILHQDFLMPGATQNYPRLPTHGELDHAFDNGVKAPFTDANDVGRFAAAALRDPDTYGGQEIDLGSEALSIQEAHDILVKVSGRQVGLRKRTPEEQEQIKPTVFGQRFQLYANVADFSGKVAAAKDVASKFGIPFTTLKESLERDKARLLECLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY82</accession>
    <name>A0A7D5UY82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g060150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544585.1">
        <property type="nucleotide sequence ID" value="XM_014689099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY82"/>
    <dbReference type="GeneID" id="26242997"/>
    <dbReference type="KEGG" id="mbrn:26242997"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="60"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="46668" checksum="EB4BFAE121786428" modified="2021-02-10" version="1">MELKTITVHAGTIFDSKAKKFKENVSITVDPGTGSIVHVLQRDTGAANIREGDIDLRDKIVMPGFVDAHTHIFLHAYKERPSLEQMRDESIVERTIRATNHVRRALLSGYTTYRDLGTEGMASFDTNVRDAINRGLIPGPRLFVATECLASTGSYQLRSENTANGASGPRISDPCDGPVSCRAAVRRRVAAGADIIKFYADYSRQAMRFPAVETHGSSIPVQFPPRNPNPAIVMFNQDEMEAIVEEAHLAGLPVACHANTAEGAAMAAKAGVTSIEHGNLMTTEVFMAMQRSRTIFVPTLAVMELLRKPDLARLQRNVRQAFDMGVRLAAGGDTGAFNHGEGTRELELMMEAGIPVEDVLEACMVGGWESCGKNSCGYRFGWFEEGNRADIIALDADPRVDGRALRKVSFVMKDGKVWKSGGVAVGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYC1</accession>
    <name>A0A7D5UYC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein PLM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PLM2</name>
        <name evidence="3" type="ORF">G6M90_00g070910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986964.1">
        <property type="nucleotide sequence ID" value="XM_066130943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYC1"/>
    <dbReference type="GeneID" id="26241997"/>
    <dbReference type="KEGG" id="mbrn:26241997"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="592" mass="63239" checksum="DD46FA2E86E9B808" modified="2021-02-10" version="1">MDSSPPRAAAAAAAAGNEAALPSASTSALARSSTSTTTTGTKRPAPSLLPAFEPLSSSPALPRPLKRQHTASANFKYPTPVPTSSTGILSSSPPRRPALARGTSERAPLSAVPAVELPENGETVGMGRSSNSSQFQLSANRLVSRVHVKARYIPAPSPLESNKIEIICNGWNGLKLHCQGRTWELFKGDSFTSETEGTDLMVDVLDARVMIQWPKRSAVAAENLANLSDSSWDDSPPRSHMRRASLLQSSPLRRTTRITSPESPTPMGSLPSSQRLQAILPGPASRDEGIQIYEDEPELPEPKGDDAVDVAASMRTDATASFSSELSDPEDENDPDEENDPIVHSFGPFGANIAGRLASISTRSPKQPKLHHRRPHNVSSNETLSAAATPSEVPSSPIKKRVAGPKLTCTTTTTTALTSANDIHDIPSSPPVAPRVSKEHTPTPSIEVDPAVTNHVVNQLAFSRLSSTPLSTIMQNLPADQKTGLTRDILRSSIEATRCIGIIKRQGKDAAGKALESEYYYVPEQDDDEQRRAAVVDGLRKPSLRNCRKQHKVCDPLTSTIKSGSSHPIAILLEASQDAVTISSFGGTKFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYE3</accession>
    <name>A0A7D5UYE3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g064460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986640.1">
        <property type="nucleotide sequence ID" value="XM_066130778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYE3"/>
    <dbReference type="GeneID" id="26247133"/>
    <dbReference type="KEGG" id="mbrn:26247133"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="45956" checksum="8975324A07437F05" modified="2021-02-10" version="1">MGKPLDAASPNPSSSSTPSCLTEASASMTLHPPPPHRYFDEDTAELTNDDDDDDLPPLYSDHEEFNHNTDSFTPFDPLLPRLPHGDIFETVHPFRRDETSAYFLDRRLDRDPDFLAGHIYKLCQVPPRPFVKLVGTHTESGSGGGGGDDDSNSRGSRETKTVTDFDIEIELTHLLYSDARTAQARRSIRTAGNLEKVRRGTVFATRAPGFGGAGPVPEEGTPALREWCRRYCASASWLRCFTVQRRVEGCDWDALGARLEGLARAANYRGRVEVRFPVRQARVHVYSDCRVNRWRLTPWVVALFTFSLAFVLAWPALFLATRRWETVTAEWRMSDGHARVRVRVEEAWYAVWAGTIQRAMLERRRGLLDQGDLQRTWARGGGGRQGDAVAAAVEAMGVVNRSFGWGEDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ03</accession>
    <name>A0A7D5UZ03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydroxyquinol 1,2-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">npcC_0</name>
        <name evidence="9" type="ORF">G6M90_00g067770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540534.1">
        <property type="nucleotide sequence ID" value="XM_014685048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ03"/>
    <dbReference type="GeneID" id="26246641"/>
    <dbReference type="KEGG" id="mbrn:26246641"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="326" mass="36038" checksum="7088658BD8941136" modified="2021-02-10" version="1">MAAPVNLKDLTTDNITENVHAINSQCGSLRLKYILERTVAHLHELARETRLTTNEWMAAILFLTQVGQISSDVRQEFILLSDVLGLSLLVDSIDHPKPKGSTEGTVLGPFHTEEAEHASAGSLISHDPDGEPLLVLCTLKDTDGNPISGAEIDVWETDSKGFYDVQYAERGGPDGRAVLTSDDRGNFWFKAIVPVPYPIPHDGPVGKLLKVLNRHPYRPSHMHFMFKKGGYDPLITALYLKDDPYECTDAVFGVKDSLVVELKKVEDEEIAKKYDVKLGSALITYDFVLVTDKAAAALRRQKAEEALAGLGRTFRFIDDLPVPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ07</accession>
    <name>A0A7D5UZ07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DOT5</name>
        <name evidence="16" type="ORF">G6M90_00g077790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545326.1">
        <property type="nucleotide sequence ID" value="XM_014689840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ07"/>
    <dbReference type="GeneID" id="26241359"/>
    <dbReference type="KEGG" id="mbrn:26241359"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="51"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI70470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="219" mass="22675" checksum="AB1B01DEC1F94615" modified="2021-02-10" version="1">MPVELRKRKAPQPPPAPAPAAKKATKPGRPAKSKKPEPAAKKEDEKPAAAAAAASPAPAAAPSSKKVAVGQVIDLDGFGGEIQTNDGETTTLKKLLEESGSGVVLFTYPKASTPGCTNQVCLFRDSYAPLTADGLAIYGLSADSPKANTTFKEKQKLPYPLLCDPQATLIAAIGLKKQPKGTQRGVFVVDKKGKVLVAQPGSPAGTVDKVKALVEELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ64</accession>
    <name>A0A7D5UZ64_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g078560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545252.1">
        <property type="nucleotide sequence ID" value="XM_014689766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ64"/>
    <dbReference type="GeneID" id="26241285"/>
    <dbReference type="KEGG" id="mbrn:26241285"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="448" mass="50971" checksum="A7E2877444DB1639" modified="2021-02-10" version="1">MDTPAVPAPRDSREQAILARLSVIRDQLLLLKQDRTTYIRSQDVIPLYDQTIEQVKELNAVRAEIGKHEENRLDKVLESCFQLLSLFYLTIGRNNEAPAAYSLTSTIKRLLDHLTEAALYSAKDLESIKSTLEETACAISQAQKAEESQAKHSPYLLTLLSKRVSLCQSMLDNLRKRLESIGSPLLVTHEKLISILRQISFANTKSKFSTSEVQKLRNQLLDVGNKRKDGKFVAEDGTVPPGEAEISELYERCVQWSGIVLERKGNVHESWRPTYDVLVGIRNDLEKLSLTQAWSLRETDLYDFQRQLDKIDENRQNGNFYDDKGRPADLWTQRTMLYLIRRSYAYIYSFMIASEPVSEALLPIYNQLQTLKRCLVEVKKNGGVTSVRELYPYSMKLNSLDNMRVDGKFIVNGDIPEGQGSVSGLLAECFDLNYELRVAAEEGTNSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZZ3</accession>
    <name>A0A7D5UZZ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g068840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540008.1">
        <property type="nucleotide sequence ID" value="XM_014684522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZZ3"/>
    <dbReference type="GeneID" id="26247228"/>
    <dbReference type="KEGG" id="mbrn:26247228"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="194" mass="21223" checksum="F465B3A56E2ECFCE" modified="2021-02-10" version="1">MLSVATQALTPHEKLIPCPDGKDCDIISPSRPTPAPESHLHIEGAEEPVGLYPQSETLWFLPPLQAALTTPDRGQLPPCYALASDKSILPPYRLGRGSGFFKSTIHPVVIVPSHVLLEAFMRFCARYVNTPAGGFSISTIAYVGLYIDDDGYLDLKQLSEPLSSSYLALREGKIPVRQWVNELKKLLGEPGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0C1</accession>
    <name>A0A7D5V0C1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rps-5</name>
        <name evidence="6" type="ORF">G6M90_00g071300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545929.1">
        <property type="nucleotide sequence ID" value="XM_014690443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0C1"/>
    <dbReference type="GeneID" id="26241962"/>
    <dbReference type="KEGG" id="mbrn:26241962"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="67"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="213" mass="23634" checksum="FDEB6F7D65FD6A7E" modified="2021-02-10" version="1">MSDGGDIEVENTVVSDVLPKDVVKEVGNIKLFNKWDYDVEVRDISLTDYISLRNPVYVTHSAGRYAVKRFRKANCPIIERLTNSLMMHGRNNGKKLMAVRIVAHAFEIIHLMTDQNPIQVAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTTGAREAAFRNVKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V125</accession>
    <name>A0A7D5V125_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bmr3</name>
        <name evidence="7" type="ORF">G6M90_00g068240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987239.1">
        <property type="nucleotide sequence ID" value="XM_066130864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V125"/>
    <dbReference type="GeneID" id="26246687"/>
    <dbReference type="KEGG" id="mbrn:26246687"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="56"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="558" mass="60270" checksum="9DFCAC91BFD5215E" modified="2021-02-10" version="1">MAREADVGFNGYSSEMSTGSKLNLDSEHGPVTSHPDSLRSGEVSVEYIQGPRFRFICAAIAIMMFITNMEIPVLITALIAITSDLGGFDDVSWVVSSYLLGYVAVIIIFAKFSDIFGRKPIFLLSTATFIIFSAACSAAQTLTQLIVFRAFQGIGGGGCFSLCTIMVFDLVPPEKYAQVVANISITNAVALLVGPIIGGAIAANTTWRWIFIINVPIAVPALVISVLAIPSGFPHHGQVRRQTAEKTLRHSAKKTLGRIDIPGTVLVLLAVLGLTAAFEEADKLFPWKSAYVIALLIVSGLLWIVLIWWERYLSLSNSTREPVLPWRLLTNRRMVGIFLNFLLLGGPTVIGMFIIPQRFQLVYGTSGLDAGVRLIPFTAAIPVSSIFASSLVGKYKVPPLYLILSGSCLQVLGFGLLGTLPAMLEIPARIYGYELIAGWGCGINFSLLFLMVPFVIEKRDHAIGLGAASQFRFIGSSMVLAISTSVFNSFARPRLQELGAAGADSLVAVLATLPTVVQEQIRYTLAEGYSRQTLALCVSAALQVPASLLMWTKKPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V142</accession>
    <name>A0A7D5V142_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secondary metabolism regulator LAE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LAE1_6</name>
        <name evidence="3" type="ORF">G6M90_00g087570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542359.1">
        <property type="nucleotide sequence ID" value="XM_014686873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V142"/>
    <dbReference type="GeneID" id="26244873"/>
    <dbReference type="KEGG" id="mbrn:26244873"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="448" mass="49734" checksum="E6B0D42ABDB2078D" modified="2021-02-10" version="1">MVHQKHVLRSPSFTNPAAANPSHVPVGDTNNAAEAEVSHGTQPQSDGAASEGGQAVVSSSAADDDQSGSHHIGSDVEDDAPGYGCEAVSLYPGRNYHRRPSASSTTAYIVHSSYGQPHSDRAASTRSLWARELDYREIGGRRYCKEYFMPNDEIEQLRLTIQHQVLMHAFDGELTITPLGNPTHVLDVGTGTGEWAIRFAELFPDCEVVGTDISAIQETQGVPMNVFFEIEDAEEWDRPIDHYDLVHLRGMEGAFRDWRCIYEDAFDSLKPGGWIQVTDYDGKDGSIQFFSGFSPESPVFKMMDDLFIGAEKSGRKRGMFHLDQQYFSEAGFVDIRVSEHILRMNLQEDNVGKLWLMCWLDGIEAYSLRTLTEQMGWDADVVKTACRETAREIASRAQDSESCKTMVLKMRTVLARKPSRDESPVPTSSSDESTIHGESSDSTSEIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1C9</accession>
    <name>A0A7D5V1C9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543430.1">
        <property type="nucleotide sequence ID" value="XM_014687944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1C9"/>
    <dbReference type="GeneID" id="26243607"/>
    <dbReference type="KEGG" id="mbrn:26243607"/>
    <dbReference type="OrthoDB" id="4941410at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16740" checksum="8A09AAF0FB6CC2EB" modified="2021-02-10" version="1">MPEIVNRPPASECAGSAGRPNSSGSPTSSRGPRKKFNPEQKYVLNDMWEKYKKLDKQRLKPSFFLYPQAFQKRVVDTCNKRARAYNNLYRCFEEQNEQESRDRAELEAFRQARTAQQAAQRGPEQAAGQAAEQAAEQAPEQAAEEAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1I5</accession>
    <name>A0A7D5V1I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g092110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541855.1">
        <property type="nucleotide sequence ID" value="XM_014686369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1I5"/>
    <dbReference type="GeneID" id="26245323"/>
    <dbReference type="KEGG" id="mbrn:26245323"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="43912" checksum="BA8B054D987A9075" modified="2021-02-10" version="1">MPTTSRANVIARTVISQFQKLPAKRKPTVRNNGLHEWVPLSGIVAEKDGKWTCLALATGMKCLPASKLHEADGNAIHDWHAEVLAIRAFNRFLIDECKTLQQGKSASILQACGSHEPKPFRIRDGLKLHMYCSEAPCGDASMELIMAAQDDASPWDIPPSPATTESGATAASLPGRAYFSQLGVVRRKPARGDAPPTLSKSCSDKITLKQCTSLLSSLTSLFVDTSSAYIDTLVLPGSQYSATGCQRAFSERVNNLMNVSWPGGYQFRPFTVETTDEEFELSRKTIRERSENIAPSNISAAWSATGVEETILGGVLQGRKPFDVKGASKMSRRQLWLAAREVSNSLNGYGGIRQLLSSKTYQDVKNGELLADRRHVKQHVRTTALAGWIPNVGDSNFSICTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1M2</accession>
    <name>A0A7D5V1M2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-hydroxybutyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hbd</name>
        <name evidence="6" type="ORF">G6M90_00g082720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987314.1">
        <property type="nucleotide sequence ID" value="XM_066131208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1M2"/>
    <dbReference type="GeneID" id="26243673"/>
    <dbReference type="KEGG" id="mbrn:26243673"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="33673" checksum="405894B2ADAEA293" modified="2021-02-10" version="1">MHATIARLVRSSVTVLGAGSQGRRLAYMWSSRGNDVHLIDGKPSQLQASVENVNQLRSQLDPNGNFGKVRAHSPDFMRAALSESWLVVECIPERLRLKQEVMTQLDDLAPENTIIASNSSSYPCSEIVSGLSLKNAKRVLSAHTYWPPETTVIEIMGHESTDPSLIRTMMERCAAHGFSPFHVRSSSIGYIYNRIWAAIKREALLTAAEGAGTPEEIDAIFRGVLKTEKGPFELMDIVGLDVVFDIEQHYAAARRDIPEQPRSYLASYLEKGHLGAKSGRGFYRYDSSPSMQPAGHREIASTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V248</accession>
    <name>A0A7D5V248_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546174.1">
        <property type="nucleotide sequence ID" value="XM_014690688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V248"/>
    <dbReference type="GeneID" id="26240597"/>
    <dbReference type="KEGG" id="mbrn:26240597"/>
    <dbReference type="OrthoDB" id="5334391at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="605" mass="67060" checksum="F5EEB9CB52FF6C55" modified="2021-02-10" version="1">MSWIAVPSRLYYKLRRNTHAAPKPATRPSPSPAAVQPRRPPNTRLCHPPAMNLALLPYTVFFEIVSHLSAPEALASRRISRDVRSALVRPDLSISLILLHFPRSVEGRALRGHLRAGRHGPLEEEDWAAVFATLARRYHHLGSATPWRVDKVRVAGGPGLRGVTPWNRFLRLDDKTAAFDYWDPVWTFAPRQGVLVYPAAAAAGAATVVYRARDLASGDEAEVPFDAGGKVVRRVRLSHGILVVEWCEEEQGRDEADGVGAAAHRHFATAFDVVPGSCGRGRRRRVQVSFRSEWKTHCLGLPLSHQDRFFSTHNATHYVVYIWQPTRSPWGEHAPLERLVVWDISRPSPYRPSLDPAGGLAPPSSSSPGPRIIRRIANDDLSGWGVRQADTPRLRGLALDRNTWDADARSATGHVFLVEEEHRWCAGPHSSATPPRQHHLRTTGIPLVGDGPRWVDDCGGRGTFADHGMEFCPRSCRASCADDGVDGVDAAEDSSAWPGRTPCWRHDDFPYLTVSEAHDALAGVRITARHCFMMETLSVHVRPRLCVEGVARYRSGDRAHAAPDDDEVRFEDGLWSQLMGKGCIAGDERWVVGEDEAGDVTILMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V264</accession>
    <name>A0A7D5V264_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g083650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987527.1">
        <property type="nucleotide sequence ID" value="XM_066131230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V264"/>
    <dbReference type="GeneID" id="26243762"/>
    <dbReference type="KEGG" id="mbrn:26243762"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="397" mass="45604" checksum="0702E422F3039542" modified="2021-02-10" version="1">MIDSGDRFYAPSGAIYPGGPSTWHIIDWDQRRLVSVTMNEELESEDPAFEQLIKHIDSLPPDVYEIHVSPDGNLISTSADPKDDETRCAYYPPLDSVQRPEGVQVISRSHLQEIDRLGPNVDLVTCPHSSEPTQKVSSPKPHFSPPSNSDLLWMRLPKHPNIVPFHSIVVDELEGRFVGFTSVYIPGGTLEENNTRTFKLKWLHQLINVIDGLNLNLGISHQDIAPRNLLIHEPTDSLMLFDFDFSARIGRTGYSEARNDVKGTLFTMYEIITRNDNLRAIRHEDQDVSLIEHKEWVRHPDVQLDRPVSEFRCVLEEWCERRRAGKQITLNTEAPNFLDWPPFPDPPLSEVQVHYVGGTVKEMKKLYDWKRTDLQKQGKTILKWQRPPQRAKQGQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2M2</accession>
    <name>A0A7D5V2M2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541116.1">
        <property type="nucleotide sequence ID" value="XM_014685630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2M2"/>
    <dbReference type="GeneID" id="26246105"/>
    <dbReference type="KEGG" id="mbrn:26246105"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028844399" description="Transglycosylase SLT domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="23789" checksum="D1A6F6A55291014A" modified="2021-02-10" version="1">MLGNIALASACLAAVVAGLPATKRGIQDKYTYYQGDGSVAAGWPSMDSWGSWDDLWKANSGLMNNTCTWNGWGQDDSSDEIAAVGSAIQDVANQTGVDERFILAVLMQESKGCVRAPTTNNGVVNPGLMQSHDGSGTCAGVDPCPSSQITQMVHDGVAGTSSGDGLQQLIAKAKGTVSGDSQVYYAAARLYNSGSANYANLDLGMGSTACYASDIANRLTGWTLATTACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3F3</accession>
    <name>A0A7D5V3F3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g097800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546562.1">
        <property type="nucleotide sequence ID" value="XM_014691076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3F3"/>
    <dbReference type="GeneID" id="26240985"/>
    <dbReference type="KEGG" id="mbrn:26240985"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="274" mass="30329" checksum="E84B359A96E5B4D5" modified="2021-02-10" version="1">MRLILDFDGTITQKDTIGELAQAAIDLQRRRTGRHLQPVWDDAVQAYLKDYESYKANFYPPEASRKDVETETNFLAGLKDIEEASLSRVSQSGIFAGLQRDDFFQMGVDAVLSGRVSKTEGFEELLRSAESKGLKVDVTSVNWSKAFIEGVLHPQHLGVAANDISEKGEIKGPRSLGGVRVTTSPDKLNALRQITQIDQRVLYFGDSTTDLQCLLYSHGVIIAKDATSSLLSTLSRIGIDVPHIGNLQNHPHTKLFWARDFREVLASGALEQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3J2</accession>
    <name>A0A7D5V3J2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">RPS1</name>
        <name evidence="8" type="ORF">G6M90_00g088620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542253.1">
        <property type="nucleotide sequence ID" value="XM_014686767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3J2"/>
    <dbReference type="GeneID" id="26244767"/>
    <dbReference type="KEGG" id="mbrn:26244767"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="256" mass="29041" checksum="ECDE125118A2A78B" modified="2021-02-10" version="1">MAVGKNKRLSKGKKGLKKKTVDPFSRKDWYSIKAPSSFSVRDVGKTLVNRTTGLKNANDALKGRIVEVSLADLQKDEEHSFRKVRLRVDEVQGKNCLTNFHGLDFTSDKLRSLVRKWQTLIEANVTVKTTDDYLIRLFAIGFTKRRPNQIKKTTYAASSQIRAIRRKMTDIIQREASSCTLTQLTSKLIPEVIGREIEKSTIGIYPLQNVHIRKVKLLKAPKFDLGALMALHGESGTDDQGQKVEREFKERVLAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Q7</accession>
    <name>A0A7D5V3Q7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi to ER traffic protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GET4</name>
        <name evidence="3" type="ORF">G6M90_00g107040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544132.1">
        <property type="nucleotide sequence ID" value="XM_014688646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Q7"/>
    <dbReference type="GeneID" id="26243519"/>
    <dbReference type="KEGG" id="mbrn:26243519"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="331" mass="36166" checksum="128B26A61D2D23B4" modified="2021-02-10" version="1">MASKVDKIVARLQQKITDGDFYEAQQQTRVAASRYIKTKSWDAAIDILSSVAQSLLKAGQGGSGGDLCTMMVDVYKQAELTPDSTSKGRLLTCLRLFDGEEPTRKKFITEMLAWSSKFGEYPAGDPELHHVAGSIYAEEHDTYEAERHLLLGTKDSPQVLFKMEYTWYKEGDAHLAPHFAGRAVLPYLLVGNVRAANNCYRLFTSALSSDNPSLGVQDVSSASSDIRIFPSLPLLNFLGLLLLAIQRAAPEVYKGLVSKYATQINEADAWTEPLEMIAEMYFGIAKPRQSNPLMDMMSGLFGGGGGGGPPPQQPRRQGIRGPDAPVAEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V427</accession>
    <name>A0A7D5V427_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">act</name>
        <name evidence="4" type="ORF">G6M90_00g106650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539881.2">
        <property type="nucleotide sequence ID" value="XM_014684395.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V427"/>
    <dbReference type="SMR" id="A0A7D5V427"/>
    <dbReference type="GeneID" id="26247320"/>
    <dbReference type="KEGG" id="mbrn:26247320"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="375" mass="41593" checksum="E7A22AA9C2125094" modified="2021-02-10" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAIARVDMAGRDLTDYLMKILAERGYAFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGLSDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4G9</accession>
    <name>A0A7D5V4G9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein rhb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rhb1</name>
        <name evidence="13" type="ORF">G6M90_00g095510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546779.1">
        <property type="nucleotide sequence ID" value="XM_014691293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4G9"/>
    <dbReference type="GeneID" id="26241202"/>
    <dbReference type="KEGG" id="mbrn:26241202"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI73773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20719" checksum="CC992E535BB8027A" modified="2021-02-10" version="1">MPAPKQRKVAIVGSRSVGKSSLAVQFVDGHFVDSYYPTIENTFSKTIRYKGQDYATEIVDTAGQDEYSILNSKHFIGIHGYMLVYSVSSLPSFEMIQVIREKILNHLGSESVPIVIVGNKSDLRPEQRQVSPEEGKKLSDKFQCGWTEASARYNENVGRAFELLIAQIEKSQNPGEAPEKGNCSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4K3</accession>
    <name>A0A7D5V4K3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539681.1">
        <property type="nucleotide sequence ID" value="XM_014684195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4K3"/>
    <dbReference type="GeneID" id="26247512"/>
    <dbReference type="KEGG" id="mbrn:26247512"/>
    <dbReference type="OrthoDB" id="4958319at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028894652" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="61" mass="6938" checksum="2505365E968E0B7F" modified="2021-02-10" version="1">MKVKLFFFFASFGLAIAGQQKEPEARAANAYTKDNHNLKYVNNIPMDKTSEQVKIENKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4X1</accession>
    <name>A0A7D5V4X1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-dependent protein deacetylase hst4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hst4</name>
        <name evidence="7" type="ORF">G6M90_00g101990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546147.1">
        <property type="nucleotide sequence ID" value="XM_014690661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4X1"/>
    <dbReference type="GeneID" id="26240570"/>
    <dbReference type="KEGG" id="mbrn:26240570"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="65536" checksum="432DCEE1B7BBAFD9" modified="2021-02-10" version="1">MEEITSSPLSNVTASPLSSLSKTPSLPSSPDVQPDAGVRYPSPTSTSTSGTQSPIKLGDPVDDSPRPAKKRRITPPRERITAYLDLMKSHDDFSHEDNFHMERLLSALRKKKKIVVVAGAGISVSAGIPDFRSSTGLFAAQRNQHKLKASGKHLFDASVYKHESSTSSFHTMVREMSEMSKNAHPTPFHHLLASLAQEGRLLRLYSQNIDCIDTSMKPLHTQIPLEPKAPWPTTIQLHGSLDKMVCTKCADIQPFQGDIFDGPEAPLCESCKNLDEVRTAHAGKRSHGIGRLRPRFVLYNEFNPDEDAIGNVMRADLRARPDAVLVVGTTLKVPGTRRLVKQLCQVARGRKDGLTAWLNIDPEPKIPDFKDCWDLVVKSTCDNIARLASLPPWDCEIGDDYLVSKEQERERLSSPPAKFEVRLDGKPTSAEDLQAIPTPRASPPPPPPLLQSSGRKPLPEAKQTKLPFGNPKPVALTKAGKSAKPRSRNPKQPTKAAQPPPTNPILQAFKASKNVSDAASAKKLGARSPLPDCKPCKVEPNLVLSLPSPGHDGKTPERVPAAGDHNPTASPTTPTMLEHQLGETISPKSIPNNMRNLIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V593</accession>
    <name>A0A7D5V593_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PATG</name>
        <name evidence="10" type="ORF">G6M90_00g108590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543987.1">
        <property type="nucleotide sequence ID" value="XM_014688501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V593"/>
    <dbReference type="GeneID" id="26243374"/>
    <dbReference type="KEGG" id="mbrn:26243374"/>
    <dbReference type="OrthoDB" id="4932559at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="8"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="35388" checksum="8744FD1A5A28924B" modified="2021-02-10" version="1">MSAIPKVNVHHHIMPPQLRGVDEGLKGMKVPDWSVSSDEAFNKSVNVHSAIFSVSTPGVTFISDPEESAKVARAMNEYSASLRDQNPSNGFFATLPSLEHTDLVLREIRYAFDTLHADGVTLFTSYATPGGYLGHPEYVPVWEELNRRNAVVFVHPINHKDSVYWDERLPMPAFDWPHETGRTAMDLILKRRPQQFPNVKIILSHGGGTLAALVTRACMIELPEFGGVMSAEDIVSQAKSFYSDLALSGSNEMLPLILGFAKKSHLLFGSDFPHATAPFSQKFTKFIDEFPMDDDARKEIYHGAAEKLFPRLKGKFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5K3</accession>
    <name>A0A7D5V5K3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AMT16</name>
        <name evidence="8" type="ORF">G6M90_00g101810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546164.1">
        <property type="nucleotide sequence ID" value="XM_014690678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5K3"/>
    <dbReference type="GeneID" id="26240587"/>
    <dbReference type="KEGG" id="mbrn:26240587"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="66"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="375" mass="40556" checksum="0FEF3A6FBBD03535" modified="2021-02-10" version="1">MSQFYIENKNVGNKADSEDWRIRGYNPLTPPDLLQHEIPQTTASKRTVIESRDEVAAVVNDTDERKRLLVVVGPCSIHDPEAALAYCDLLLQAREKHKGELLIVMRSYLEKPRTTVGWKGLINDPDIDGSFKINKGLRLARQLFVDLTAKGMPIASEMLDTISPQFLADLLSVGAIGARTTESQLHRELASGLSFPVGFKNGTDGSLGVAIDAIGAVRHPHHFLSVTKPGVVAIVGTTGNEDCFVILRGGTRGTNYDAASIAEAKAALEKKGVSPRLMVDCSHGNSLKDHRNQPKVAANIAEQIAKGETGIMGVMIESNHNEGNQKVPAEGKSALKYGVSITDACINWQDTESVLDVLADAVKQRRQVLGINGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5P0</accession>
    <name>A0A7D5V5P0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539756.2">
        <property type="nucleotide sequence ID" value="XM_014684270.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5P0"/>
    <dbReference type="GeneID" id="26247421"/>
    <dbReference type="KEGG" id="mbrn:26247421"/>
    <dbReference type="OrthoDB" id="5422777at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="378" mass="42571" checksum="BA593D1475BC3FDB" modified="2021-02-10" version="1">MSASSVVSQLRSLFDKADQLIPKLNKIYPTDEQWESLGDFSAKLATAATTIGQRVQALKESRADRAWKESEKLRSHALKCQGDVLANGRLKQSPVFRRNIVTIFEGPKDSKFDTEDTRVRKATTRQRCAQIRSLSPDGIISWAIAFAPSLWAGGSMATDIFKCLLEDIEPDCHPSWPSIVGETLHTLQADEEVLQRSTDYQKLLCAYDTPLATNLESNRKRKRLDHKRPSTILGQKGEDIPCLRRNVAKVLLEQSQYNNDKSTLSRGEACDPESRQGKQEDHSMLNPQPPNDGNREMKHMCTNAPASRVEDLPEPLREAVENSRLFKWERSQGYETTGCVTAVFPKDNTQDVTFTLWCGNVQGYHLISFFGLQHAMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5Z0</accession>
    <name>A0A7D5V5Z0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g102230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546123.1">
        <property type="nucleotide sequence ID" value="XM_014690637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5Z0"/>
    <dbReference type="GeneID" id="26240546"/>
    <dbReference type="KEGG" id="mbrn:26240546"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="387" mass="42880" checksum="1B96181452CA73F0" modified="2021-02-10" version="1">MRTSHFPTPVVISRSLSRPRQRQLQDPLWRGRYERRYSADSPPGTSDRQKKLSKLPFRFETGIGLFAKRQPRPFPPPFTSPPSASFSDPLSTHHRSRDRRGAFVNGELIKGLTNGDDAVYASDFFICANDGVGAWAMRPRGHAGLWSRLILHFWVAAVEEDVLRSLSAGTPHTPDPKSMLQYAYERTLDATVSLDWQGTTTACGAQLHYRASSDNLSVNPLPLLLVTNLGDCQVMVLRPRNKEVVFKTKEQWHWFDCPRQLGTNSPDTPKDNAVVDTIDLEVGDVVLAMSDGVIDNLWEHEIVESVVKSIRSWESEKGGGLKEDRIGGRNGGMKVAAEELVAAARVIAMDPFAESPFMEQAIEEGLASEGGKLDDISVVAALCVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN83</accession>
    <name>A0A7D5YN83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA mismatch repair protein Mlh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Mlh1</name>
        <name evidence="8" type="ORF">G6M90_00g023080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548247.1">
        <property type="nucleotide sequence ID" value="XM_014692761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN83"/>
    <dbReference type="GeneID" id="26237691"/>
    <dbReference type="KEGG" id="mbrn:26237691"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000033">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="244"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="722" mass="80786" checksum="09CCEEDF0198F19D" modified="2021-02-10" version="1">MEEMDLDAPAGRKRKADDIPDDPRPARRIKALDPDVVNKIAAGEIIVAPVHALKELVENAVDAGSTALEILVKDGGLKLLQITDNGCGIEKEDLAILCERHTTSKITAFEDLSSIGTYGFRGEALASISHIAHLSVTTKTKDSPLAWRAHYLDGKMVAPKPGQPAEPKGVAGRPGTQITVEDLFFSIPTRRRAFRSYSDEFNKIIDMVGRYSIHCQGVGFTCKKAGESSNTLSIQSQATTLDRVRQIYGSSVANELVDFSASDARWGFKAHVLATNANYHIKKTTFLLFINNRSVESANVKKAIEQTYLNFLPKGGHPFVYLSLEIDPARVDVNVHPTKREVHFLNEDEILHAVCTELESRLAHVDTSRTFKTQTLLPGAKPVPESMDEDQSSPRIMVTGKRRRNSNDLVRTDTYARKITTMLSHADSGEGSKAKTSKEEEPLAVPENIEYETNDREMTACRLKSIKELRSEVRDNIHHDLTEIFASHTFVGIVDDSRRLAAIQSGVRLYLVDYGHTCFEYFYQLGLTDFGNFGVIRFSPPLGLRDMLQMAAETEKKVLGAADHDFPVEKIVDKVANQLIERREMLHEYFSLEVSPTGELISIPLMLKGYTPPLSKLPRFLLRLGPNVNWNDEKECFDSFTRELATFYVPEQLPTPPAPGGGEEEEEIPEEMRTRRQHVRWAVEHIFFPAFKTKLVATKALMDGGILEVASLKGLYKVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPI8</accession>
    <name>A0A7D5YPI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g029880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985942.1">
        <property type="nucleotide sequence ID" value="XM_066130046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPI8"/>
    <dbReference type="GeneID" id="90967566"/>
    <dbReference type="KEGG" id="mbrn:90967566"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028949386" evidence="3">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="229" mass="24501" checksum="DF6FF482850A1B4C" modified="2021-02-10" version="1">MRQCTLWPQLAALLLALGHAFAQEADTLKNKIGWTEEELLRDLTPIPTGVPQNDPWALPLINGCPRNCVEAGPDSANWTQLYDQNHLSLCKYPLLFAFNVHNGPSRYSTIRVCALNGGDGKRSTSAVVVPEKDGDAAPPATGLPTASFSECGAGESTTEATVKAGFDVVSENTRPDAMSAANFLISHLSSNTACGNVILFAKFGVALVGLYAGADLKKDRAAELLHKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQY4</accession>
    <name>A0A7D5YQY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CAT5</name>
        <name evidence="8" type="synonym">COQ7</name>
        <name evidence="10" type="ORF">G6M90_00g011070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986105.1">
        <property type="nucleotide sequence ID" value="XM_066129703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQY4"/>
    <dbReference type="GeneID" id="26238858"/>
    <dbReference type="KEGG" id="mbrn:26238858"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="212" mass="24017" checksum="F8123CD63A7C638E" modified="2021-02-10" version="1">MSTTCSLSQTPSEPSSDTKKRKPLTREQRDFLSSALRVNQAGELAATLIYKAQTPLVVRQHPHLRPLMAHMYDQEAGHFATFNDLIHKHRVRPTALYPLWSVLATGLGWSTALMGREAAMACTEAVETEIGDHYNNQIREILEMITQWEAEGYQVSTEIGELVQTLRRIRDEELEHLDHAVEHDAKKAEPHWLLTGVIRAGCRGAIWVSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSY8</accession>
    <name>A0A7D5YSY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">54S ribosomal protein L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRPL16</name>
        <name evidence="6" type="ORF">G6M90_00g049750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545082.1">
        <property type="nucleotide sequence ID" value="XM_014689596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSY8"/>
    <dbReference type="GeneID" id="26242423"/>
    <dbReference type="KEGG" id="mbrn:26242423"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000003">
        <property type="entry name" value="54S ribosomal protein L16, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27975" checksum="4C9C5DB7828C0C98" modified="2021-02-10" version="1">MASVNSSAFLNAFRGLRICASIPLRQIRTPILRQSRTLEAAALLPNVRAFSTTSPVLGTWLEPSLNRKKKMAKGRPRVATGGSTKGTTVIWGDYGLRMIDHHRRISAKQLKMAEDTIKVRLRGEKYRLYKRKCCNVGVYVSGNEMRMGKGKGSFDHWATRMAVSQVLFEIKGRIHEQIVRDAFRLAGNKLPGQWEFVKKGDAPVVGITKLDGITLEDLKRPRRQIAPTELLQASASTPVTESGSTSDASRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUC6</accession>
    <name>A0A7D5YUC6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g081810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987412.1">
        <property type="nucleotide sequence ID" value="XM_066131184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUC6"/>
    <dbReference type="GeneID" id="26243593"/>
    <dbReference type="KEGG" id="mbrn:26243593"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43845:SF1">
        <property type="entry name" value="BLR5969 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51110" checksum="D8FFD55BC5FE61E7" modified="2021-02-10" version="1">MAPENYTLSDVLAVAKSHPFYDQDIQYPPDSETIEKLREQSREQPESDGLKLQPLLRKKDLYTTIERLVNDPSPQNTYRHSIYASITGGGFGSKPLFFATDVHENRRHRAQFGELLRATGVVKHGDWILTTHCADLMLEILENAGASVLSAGNHMPPEEVIHLLIKYHINVLAGDSSQVAQLIHRISGLAPESRALLRLDKIIYTSEVLTAAQRAHIKTVLGNHVKICSIMGSAEAGPWALSNPDLTGQEAHTSQADFIFDTRAMLLEVLSPSSQQGEGGSDPAPVPEGHEGIVVQTSLSRLRNPLVRYDTGDIGSLHPLPAQARGLVPEEYWPFLRVLRFQGRDRRFSFDWDGEYLDFVDLTALLNAEACGVLQWQVILDKLEPSLESSLEIRLLRSPPNVKLLPEQELAERIRTFVHAYSANEHRFRLVFVDGLDGFERSSTGRKVIKFIDRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUC9</accession>
    <name>A0A7D5YUC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">tRNA-dihydrouridine(20) synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dus2</name>
        <name evidence="12" type="ORF">G6M90_00g012630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549260.1">
        <property type="nucleotide sequence ID" value="XM_014693774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUC9"/>
    <dbReference type="GeneID" id="26238704"/>
    <dbReference type="KEGG" id="mbrn:26238704"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="11">
        <location>
            <begin position="89"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="457" mass="50029" checksum="43FA0F464D3BBA17" modified="2021-02-10" version="1">MDRGCFTLARFGDATSPKPLVLSGHTRHVDLPPWGMVLTLLRRMMAAEVKKVPIPRRGVDYRGKIVLAPMVRSGELPSRLLALHYGADLVWGPETIDRAMIGTTRRFNQDTRTIEWTRMSSQGHKEPPPDAKESIIYRVFPEKEANKLIFQIGTADPDRAVQAARLVAADVAGIDVNAGCPKPFSTSGGMGAALLRTPDKLVAILEALVKNITPEFDIGISVKIRILETPADTEALVRRLVATGITGLTVHCRTTPMRPRERAIRDQLRMVVNICHEAGIACIMNGDVENRDQGIKLAEEYGADGAMIAVAAEKNPSCFRSEADGGLLGWEPVVEQYIKYAMEISNRFSNTKYLLAQMIPGKAKPYKTVQQSKSYTEVCNALGLEHLLEKAQDCDVQRGLDKPKEKLTKKARKNASALAAGGQMVEARAQSHHRKTLSERNVGSKAAPEPAPVATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVD3</accession>
    <name>A0A7D5YVD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Patulin synthesis protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">patF</name>
        <name evidence="1" type="ORF">G6M90_00g094550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540820.1">
        <property type="nucleotide sequence ID" value="XM_014685334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVD3"/>
    <dbReference type="GeneID" id="26246433"/>
    <dbReference type="KEGG" id="mbrn:26246433"/>
    <dbReference type="OrthoDB" id="3814701at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="155" mass="17043" checksum="83E7A0ECEE331D4F" modified="2021-02-10" version="1">MSTPVQIVEKLLSNMTNDDVVASLVAPDATYVSLNHSNPDLKKIMPWCGTWQNAGPSAFINTFTGVAHFWDNEGSKTDAIFGSGENVAAFGRMTLRSKTVGIAKTVPFSVWCVVKNDKITFMQFMEDTFDTAATFRSGGAWTFRANPDTKEEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW35</accession>
    <name>A0A7D5YW35_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MTH_47</name>
        <name evidence="12" type="ORF">G6M90_00g003430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>isopentenyl phosphate + ATP = isopentenyl diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541999.1">
        <property type="nucleotide sequence ID" value="XM_014686513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW35"/>
    <dbReference type="GeneID" id="26245030"/>
    <dbReference type="KEGG" id="mbrn:26245030"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040647">
        <property type="entry name" value="IPPK_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="ISOPENTENYL PHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="11">
        <location>
            <begin position="3"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="309" mass="33984" checksum="AE5B24312EFD2AE0" modified="2021-02-10" version="1">METVVVKLGGAAITDKSLADTLSPNIHGLVDKVVQVYQDKLRPLGRRLILIHGAGSFGHPPAKKYNVKAGWLSPTGATEDKRDGHTRQEEERRDEVKFGMALTRQRVLQLHHHILQLLQDRGRLPVLSVSTYDTVETDQGVLTQEGSRRLITRVTNLLTQGFVPVLFGDAVLDHAWGATILSGDALMHELATHLPGVRRCVFVTDVPGIFTQDPKQYADAVLIRQLHFSESGDSATYDDDAASGVDDVTGAMRTKWQWAKRIMTDAHQVNRVIICQASVSDKAIGLVDEHDCNGLDGGDGSDAWTTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW59</accession>
    <name>A0A7D5YW59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KGD1</name>
        <name evidence="18" type="ORF">G6M90_00g008040</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549704.1">
        <property type="nucleotide sequence ID" value="XM_014694218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW59"/>
    <dbReference type="GeneID" id="26239148"/>
    <dbReference type="KEGG" id="mbrn:26239148"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="671"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI65865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118406" checksum="7D5C0711E8141DC2" modified="2021-02-10" version="1">MLRNPLCRASSQVLRGARCSAALSRSSIPTVSARTSSWKLAAVRRPLAATAARSYATDALHSPPDPSDNFLSGGAANYIDEMYMQWKQDPKSVHVSWQVYFKNMESGDMPISQAFQPPPNLVPNMTGGVPRLAGNLALDDGSDVTNHLKVQLLVRAYQARGHHKANIDPLGIRNTAEGFGNIKPKELTLEHYGFTEADLDTEYTLGPGILPRFKREGRDKMTLREIVAACERIYAGSWGVEFIHIPDREKCDWLRERLEVPQPFKYSIDEKRRVLDRLIWSSSFESFLATKYPNDKRFGLEGCETLVPGMKALIDRSVDYGVKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFAGTLGAEDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKTRAIQHYNNDEKTHRTAMGVLLHGDAAFAAQGIVYECLGFHSLPAFSTGGTIHLVVNNQIGFTTDPRFARSTAYCTDIAKAIDAPVFHVNADDVEAVNFVCQLAADWRAEFQHDVVIDLICYRKHGHNETDQPSFTQPLMYKRIQQKEPQIDVYVNKLLREGTFTKEDIEEHKQWVWGMLEESFDKSKDYTPTSKEWTTSAWNGFKSPKELATEILPHHATGVDSKTLDHVGEVIGSAPEGFQIHRNLKRILTNRTKSVVEGKNIDFPTAEALAFGTLVTEGYHVRVSGQDVERGTFSQRHAVFHEQENEKTYTPLQHISKDQGKFVISNSSLSEFGALGFEYGYSLQSPNALVMWEAQFGDFANNAQCIIDQFIASGEVKWMQRTGLVMSLPHGYDGQGPEHSSGRLERYLQLSNEDPRIFPTEEKLARQHQDCNMQIAYMTTPANLFHVLRRQMHRQFRKPLVIFFSKSLLRHPLARSNIEDFSGEDAGFQWIIPDPEHQTGAIKAPEEIDRVILCTGQVWAALHKYRADNKVDNVAFTRIEQLNPFPWQQLKENLDMYPNAKTIVWAQEEPLNAGAWSFTQPRIETLLNQTQYHDRKHVMYAGRNPSASVATGAKHLHKKEEEDFLEMAFTVKQDKLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX49</accession>
    <name>A0A7D5YX49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xanB_0</name>
        <name evidence="7" type="ORF">G6M90_00g003460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985825.1">
        <property type="nucleotide sequence ID" value="XM_066129552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX49"/>
    <dbReference type="GeneID" id="26245033"/>
    <dbReference type="KEGG" id="mbrn:26245033"/>
    <dbReference type="OrthoDB" id="5594057at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="5">
        <location>
            <begin position="112"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="6">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="50733" checksum="017251A15AD554BA" modified="2021-02-10" version="1">MAAQTGIEAALAKIMDVVQKQNEEMSELRQECAQLRHSNTEISQLLRETVMGRRDSTGLAVFTPGGDGSLRSFSPHPLPKLSPAMRYIPPPSPSPQLTVPAMDREIPGFYVIIPAGGAGTRLWPLSRENHPKFLLDIDLSGRSLLQSTWHRLVPLAGSSRMTVVAGPCHSESIQTQLPQLESDNLFTEPGPKDSMAAIGLAAAILLHRDEDAVIGSFAADHMIAGEDAFLNSVTEAVKVAKEGFLVTIGIAPSHPATGFGYVKLGDKLDVPNAPSARLVSAFKEKPDAYTAAKYLSSGNYRWNAGMFVTKASTLMDLVKEYEPELHSDLTRIAKAWEDKTQRETILNEVWPTLEKVAIDNAIAEPAAAEGRVAVIPATFGWDDVGDFSSLAEMLPAEANSPRILGDRNLVVAQQAPGGIVVPGSGRLVACLGVDDLVIVDVPDALMVTTRARAQEVKSLVASCRKAGFKNLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX52</accession>
    <name>A0A7D5YX52_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">APE2_0</name>
        <name evidence="15" type="ORF">G6M90_00g031600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543098.1">
        <property type="nucleotide sequence ID" value="XM_014687612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX52"/>
    <dbReference type="GeneID" id="26243899"/>
    <dbReference type="KEGG" id="mbrn:26243899"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="250"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="541"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="884" mass="99655" checksum="C98B19BA718B4008" modified="2021-02-10" version="1">MADREILPDNLKPVHYNVSLRDLEFKNWTYQGTVTIDSEIVKPTKEIVLNTVEIKITSAKVLVDHTKSSQAIQSTNFTYDERAQRATITFDQELPVSKKASVVIDFEGIMNNEMAGFYRSKYKPAVTPAKSVPRDDEWHYMFSTQFESCDARRAFPCFDEPNLKATFDFEIEIPTDQVALSNMPVKETKPTKDGWNMVSFETSPVMSTYLLAWAVGDFEYIEQLTDRRYNGKQIPVRVYTTRGLKEQGRWALQHAPKIIDFFSKIFDIDYPLPKSDLLAVHEFTHGAMENWGLVTYRTTQVLFDEKTSDARFKNAVAYVVAHELAHQWFGNLVTMDWWDELWLNEGFATWVGWHAVDHLHPDWQVWAQFVNEGMEAAFRLDGIRASHPIHVPVRDALDVNQIFDSISYLKGCSAIRMLANHLGVETFLKGVSNYLKAHAYGNAKTKALWDALSEASGKDVNALMGPWISKIGHPVVTVAEEPGQISIRQSRFLSTGDVKPEDDTTTWWVPLGLEGKKGETGVNTMSLLQKEETIRDIDDEFYKLNSGATGFYRVNYPPARLAKLSTQLDKLSTEDKIAIIGSTADLAFAGNSTSAALLTFLEGFSKETHPLVWTQVLDSIGSVKSVFNEDKEIKTGLENFALKLISDKVKEIGWDAAENEEYLTTMLRKRIIGVAVASGHAEAEKEALRRFNAWHENAEANPLPPSLRLPVWRAAVKKDTARAVEILKNEWFNTKSIDGKLICLNALSAPEDEQILKEQIVSFNFNESPPSNAVNAADMHVLGMGLAGNPVGRQVQWAFMKANWDACVAKLGNPIVVDRFVRVSLGGFTDVSAVDDIEQFFKDKDTKSFDRTLETVKDKIRGRAAYKKRDAAALKEWLGANKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXB0</accession>
    <name>A0A7D5YXB0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alkaline protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alp1_3</name>
        <name evidence="9" type="ORF">G6M90_00g084720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541034.1">
        <property type="nucleotide sequence ID" value="XM_014685548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXB0"/>
    <dbReference type="GeneID" id="26246023"/>
    <dbReference type="KEGG" id="mbrn:26246023"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028962157" evidence="7">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="105"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="394" mass="41917" checksum="2F825ADE09515C4D" modified="2021-02-10" version="1">MHISITLALFFGLTSARVAHAPVVESQIDQPESVINDNTLAPLELALGLKNHVKLAKRSLQTQTSAPWGLRAISHRSPGDFYEGFPPPESSKYYYDDKAGAGTFAYILDSGIRTTHEEFEGRAKAAHSIYPADQTIHGDHGTGVAGIISSKTYGVAKKATLISIHLLGPDGCTGSEAINALLWAAEDILKNSRKDSSVINLSFGIPKLQALNTFVERLIIETDVPIVVAAGNEADDASNHSPGSADGVISVGHINQQWAISETSNFGSAVSILAPGVGVETTGAGSDTNIIRETGSSFATPYISGLILNAISIHGIKGAANLKKHILETAIKDKACIPPEKEDKNNRTPNLVGNNNNAEQDKEKQEDEPSSSRMFCCNGLLSKLACGRNRPMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXL3</accession>
    <name>A0A7D5YXL3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">smg1</name>
        <name evidence="11" type="ORF">G6M90_00g025230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985596.1">
        <property type="nucleotide sequence ID" value="XM_066129952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXL3"/>
    <dbReference type="GeneID" id="90967527"/>
    <dbReference type="KEGG" id="mbrn:90967527"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9614" checksum="AF858FA4C1EBC0BC" modified="2021-02-10" version="1">MAPAQPELKKYLEKRLFVQLNGSRKVIGVLRGYDVFLNIVLDEAVEEKEGGDKVKLGMVVIRGNSVVMMEALDRIGGDDRQHHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXT9</accession>
    <name>A0A7D5YXT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General negative regulator of transcription subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">not2</name>
        <name evidence="6" type="ORF">G6M90_00g023480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985950.1">
        <property type="nucleotide sequence ID" value="XM_066129904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXT9"/>
    <dbReference type="GeneID" id="26237651"/>
    <dbReference type="KEGG" id="mbrn:26237651"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="295"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="427" mass="46797" checksum="E03D56531C3FA6D9" modified="2021-02-10" version="1">MQTTTGICSGLVGLKPSLLQTSNWDYAAVVKGEFPSLSNNSQLNNANPASMWSSGASRNLSGPIQRNQSTPVSSQQGGQDDLFASGSSRLPLHQSSFRFGNQGNIATASQGQPSSVDDFPPLNRAGNGEIGSDRSGNLMSLAFGSQQGASGAQRGNGLLNALSANSRANDVRSPPGVALNRGQDRKRLGADDDSRQKPISREDGLGKSTVDDTNQNPLGAIGNEDSIAKLRDVKENKAPDAVDPLGGMSAVDKWGIKGLRTLMNNYPDYQAMVVGMDPITIGLDINSQEMISTQVYSLFDDAPPRPTVNGSKFRLPECYNVTNVQPIESKIQNFNEETLFWIFYSCPADVKQQMAAVELHSRNWRWHKKHQIWLTKDEHMTPQILSPNHERGFYIVWDTDNWRKDRRELTLFYGDLDTTLNQPPAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY09</accession>
    <name>A0A7D5YY09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ANK1_3</name>
        <name evidence="3" type="ORF">G6M90_00g104380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987628.1">
        <property type="nucleotide sequence ID" value="XM_066131642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245684"/>
    <dbReference type="KEGG" id="mbrn:26245684"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1382"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1501" mass="162172" checksum="5782EA7227476DCF" modified="2021-02-10" version="1">MEFPDPAPSPPAAGASSDSEDTTVSDWDSEPESPRPASIVHEEETNDSPDPIFISIASLSGELASLHYQQGTPTRREIEFSWAANAIVGEAATIKGIWTLANNLLQVALGAINSRRNIASPKPALIFAACDIGGTILKQALLIAASDTSKFSSVLENTNLLIFFGSPHRESDCCSWEAMLSHLILTQHKGCPGSWIPSIVSQLSSFHKDLTDKFIAFIEQYKISIISHYQVSSKSDENEMLAKKLNATLDVHGEIQIGLPRGDNTLFNVYAHEHQTLIASRVENAKASSRKDYQEWLRLLTRFGLDIPVRQGSKPAYKNLCDWILSDAGLASWADKATGASKETGAAVIKSHEQQSLQDPDSEVSNDPKTGEVPKRSQHAVARTMTTLEIGGCIRDATILTSSLISSLRERQSWPMDMFLTLAHHKPRPFPLTKAQLMACVCRQLLTGHPSLCVEIQPLLADARNALDSHNIAWIETTLWTCLAALLGGQVLGQPFLIVHQPAEPDFASPFLQLIADLAGLVQTTEISVKILVVRNVASCPDTTPDASTCINPNTARDGASSSSSTVCHVQKHANRVIIRKIIDPGDADVLKALEMDYDACFERLGPERAQVLSRKDGMEFLAASTDLGAMRYLFAVLEQHSFLSLQSVRKSLFSAISQDVVTAILNLVPKSVESVVRTGILWITHALRPLTCAEFATALGMGADDVVGDGFSTITVSEFERLLCGLVEVEDGTVYLASSLLTQHLLQQTSGHTKDSSHFLDLKPACSPDIALSCRRYILHHYRSGQPEQASEESEGGASEAQGFSDNAPGDVAAGQLDSGPLMSYAVEHWFTHLRLKDYSSGDTKLEDEFVCDGGLVHCCLRLRSSGRAFQPPESNQQAVPSIVQIRDRLHVECAEAISLALHASDIECAPDQGKCPSTVALAACQMGIASTLHQLDQCGDFGDECTLKRAFQIGSDSSLCILADRYSEFVKKNAHEILQDAVRLGNSGLIMHLMNKPDLWADSDSGQYHQPLLHVIAALGGSLPPQALWERQEQYISHASEQYQEKTPLHLASLSGQESLVSKILSKLSESEAAKASLNMRDLMGATPLFLASQRGRFTVVRQLLTAGADHSVCDNQEQSPLHVACRNGHWNIAETLLVWGASPNAKDSAGRTPLHLALENNHLGIAVMLLGDTTSAPTHERDFDVNSHASDGSTALIIATKGNHLNMVRILVGRGASVIWRDGNGRDALQYAAQYGHDQVLHELLEAAKVVGSDDVYQANPSLLSLSALAGHVQVIKMLLDRGFRDTDALVLACEYGQTAAVKVLAPYSSSASRNAGYLEAASFHRQDTVKTILAAGADIDTKSSLNLTALHHVAFSSNPRLVQLLVSRGAKLDVTDITKSTPLHYAAGQCSVECLKILVEAGAGLNVENEKGATPLYLAATAGSEDGVGILLAAKSSFTVPRPVAGEYSTFLDLALATFKLDVFRLIVKHATDISGPGLCMSPEALFLFLHGQNEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY91</accession>
    <name>A0A7D5YY91_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Highly reducing polyketide synthase sdnO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdnO</name>
        <name evidence="11" type="ORF">G6M90_00g029740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986042.1">
        <property type="nucleotide sequence ID" value="XM_066130038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245833"/>
    <dbReference type="KEGG" id="mbrn:26245833"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="3"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="930"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2251"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="930"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2339"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2971" mass="324136" checksum="9BDF69FFDE747813" modified="2021-02-10" version="1">MPIEPIAIVGASCRLPGSSNSLDSLWELLADGGEAWSSVPADRFNEAAFHHPNASDPNGTNNHQGGHFIDGDIRDFDHAFFHLSPQHAAAMDPQQRILLELVYEAFESAGWAREACAGSRTAVFAAIFGTDYDRNLCKDVLDLPVYHSVGTGIAILANRISHAFDLRGPSLTLDTGCSGGLVALHEACQSLRNGESDAALVAAANLQLMPDHYIGMSSQHMVSSTGRCYPFDLRGDGYGRGEGFVVVALKRLSDALRDQDPIRSVILNSGINQDGYTASGITHPNRVAQADLIRDTYDRLHLHPQDTAYVEAHGTGTVAGDSEELAAIAEVFAGRNRSLPLHVGSNKGSIGHTESTSGLASLLKAILMLDRQVIPPVAGFTTPKPGLPLDRITIPTQRLPWPLTEGMVPRISINSFGYGGTNAHAIVERGPRTYDASCSTTSTNSPRLFVLSANNQGSLKSLLESYVNWIQQHPKIPLADISYTLCHRRSALPWRFSCVADNESSLLDTLERGVNLTSTRPPPSKRQVIYVFTGQGAQWAGMGHELLLETTPSSVFRDSIRISRDILYELGATWDLEAELLAQDGGGRINKAELAQPATTAVQIGIVMLLRSQGVRPWAVVGHSSGEIAAAYAAGRLSHHMALRVAFHRGLMPGVSKDRGLPPGAMLSIGLGQGDAAPYLHDLTHGEAAISCINSPNSVTVSGDAAAVDEVMARIIARGDGTFCRKLRVDTAYHSHHMRAIADEYRTRLGDLDLGIDEPISPPGGLRGNEEVKYFSSISGLSWVSDFAASYWVDNLISPVRFSDAIQTLAREHHKHNGGLALFVEIGPHAALAGPIRQCLAASNVPKLEYNYLSALKRGTGAVETMLQVVGHLFERGVRVNFDEITALTPGFHTAAVRPDLPSYCWDYSSKHWHESRLSREYRMRREPYHHLLGVRMTELASMEPRWRHMVGLATLPWLAHHIIDGLIIFPGACYVCMVVEAVRQLAKEQYSEQALEAVSLRDVSFLRALVVPDAPSRVEMQLSLKHRADASPLSFTFSVTALSDGKWHVFCTGVVEGVMALDKPETESVMLDPHPKQDWLNGIVVIPEELYNEMAADGNTYGPSFRGLRSLTTSTDGLRATAVIEVPDIAASMPAQYQASHILHPTTLDSMFHVGIPMMKRWHGSGSVMPVHIGELLISTQTPALNSQGSKLEVSAKLTSSHFRASNIDMTVVSGGFPVIYASAIESRSLAYHADRAHGTQDEHGICYELAWRCDLNFLRTSDLTRNSTLADLVSFICFKTANLSIAELGESPGVLAPAFLAAVGVHRGTVTSYDVVERGNKPIDEGCKRLIGYPIRRRALDPDNSLESQGFAHNTYDVVLVSDLGSLCYVSTLVKNDGVVVIVLKPGSDDNWQSTLRKTWPSHDVQLTVVNSVNGNRIILARNDKTKHSHSSSRVHIITHSALKTTPSWATALIGKLHETGYEISSGSWSQDVIQRSSDARNTCIMVIDDLAQPILSDRACFNSAITLLRQDHRIIWLSLVSPSSMHQITGVARTAHAENDNLRLTVVHAALEAIGSPVLVDLLCHCLTYAPTRDSLAHCEREYRVSRDAAVLVPRLRRSDCLNRAIRASEKASGPSSNIETEPYHYINSTRRLALGPVQSSKGDGDIVFIDSHTVELAEGQVEVETEAFVLSKSQNLTSYQLGEYSGIVRRVGKGVRDFSPGDAVVALTLDGVVGANHARVPSSHVSRRPDSLSPAVAAALFLPTIAASYAIHHLAQISKGKSKVLIHGVLTDIGRASVAVARVLGATITATAISQQEALEITRQLNIQLENIIVSRPSLLRPRLDELLQLDAIIRISEDSVPAAAWSCLKPFGQVVVFNSSSSIAFPSPPPENATIHYCHITNLVQAQPDRLADLVSLATPALQRIPFKGIDLYIQDVAQVREAIHLVRQGGKVILQASPSSLVRTVISSSVSMDWEAADASYVVAGGMGDLGRRLLLLMARRGAMHLVTLSRRSIEPEDHRSFQEQLKLVQPGCRLYCLVCDITSESSVQNAADTLIRTGVPPVRGVIQSAVTLHDRTLETMTFDDFFAVAHAKVDGTLVLERVFASPHLHFFLMLSSAVNITGASGQANYNAGNAVQDAIAHDRGPGFLSMNIGWIEDAINTSNNKTILQGLWRTGLRPILGQELSRYFDHLLGAASSHSRMRQAIIGFNAASLSHTSASNSNVHSAMFCHIRGSLAAEESSSSTNSVRSFDEVVEGGDLDTIIDFIGSAITRRLMTLISMDDDQIKDRNGSILDLGLDSLVAIELRNWITREFKSPLQSSEILTDQPIRDLAEKVASRSSLLASGLDKEATADSLENGDAEDHHSAGAVRPSTSAHSTGKYVSEKLPPLPLPPLSDTLRLFEDSRRAIDTANHRRNTSDAVHNFLRGPGPRLYKSLQKTDSDVIAETYDRQVYLDRREPLPEQGPFIFIHSIQAPVHSQARRAAILTIAAFDFIRLLARGDIAPDTLHGEPITTEGRNWLFYATRRPGLGVDHMERHAPNHTVAVLRRGHVFQLRLPDVEQTLDMLAVTRVYDDILTASCDTIPPVCTLTADERDSWALFRLDLERRPQNAAVLACIDTAAFVMCLDDESPTNSGERYTQFMINGAHRPFANRWLDKTLQFAVTANGISAEIYEHSKLDGIDTNRLHAHIARAILAHPPSETADISSVSPPYAVQQLMWEPSSATLQRIEHVRAQCQVYGPLDHQVLDVASLGFRSLRGFRLQPNATAHLTVLLALYLVDGEIRPAWEKVSLGTFARGRVEWVQTVSPATRAFVEAAAASYTDSNNRTRVRALLHQATSTHSRAVVAAGRGLGAVRALYALRGAAQEQDKELPELFRTHSWDATRRGGPGQDVKLGFMRLAPNDDANGNIGATPGDDDINGHWDEAGFLVCGERGVYVHCNVWEKHARFAVSGRPAYVTKLCKAMERASYIITSLLDDPSKRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZR1</accession>
    <name>A0A7D5YZR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g106640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539880.1">
        <property type="nucleotide sequence ID" value="XM_014684394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZR1"/>
    <dbReference type="GeneID" id="26247319"/>
    <dbReference type="KEGG" id="mbrn:26247319"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="42"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="182" mass="20285" checksum="ED8CF1CC2E159CEB" modified="2021-02-10" version="1">MNIFRLPRRIPRTHLLATLSRPFTLTALRSKNLPPRPKPPPDAEIEESFLKGSGPGGQKINKTNSAVQLKHVPTGIVVKSQATRSRSQNRKHARELLAQKVDDLLHGEQSRSSIVGQVKKKKAASAAKKSRRKYKKLDEEREAAGEEEGPEHSPRESEGSGQVQGETTIEETKHPQENNNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z121</accession>
    <name>A0A7D5Z121_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfide:quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hmt2_1</name>
        <name evidence="2" type="ORF">G6M90_00g113670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539672.1">
        <property type="nucleotide sequence ID" value="XM_014684186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z121"/>
    <dbReference type="GeneID" id="26247503"/>
    <dbReference type="KEGG" id="mbrn:26247503"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="451" mass="49577" checksum="510CAF914027F2BF" modified="2021-02-10" version="1">MRCQRTKPAWNTALATIRSQQHNRRCFASASPVIASSRNHRVVVVGAGTAGIAVSHQLLRSGEFGPEDVAIVDPAVWHHYQPGWTLVGGGLKNKQDLRRKLADLMDPKLKFYNSSVASVTPGDNFVTLRDGDKLTYEQLVVAPGLSINYGQIEGLHDALYDPESPVSTIYNYDTCDKAFRTVERLTKGNAIFTQPAGVIKCAGAPQKVMWLALDYWKRAGLYSPNSPSSSAITISFATGLPAMFAVPKYAAKLEELRKERGVEGLFQHDLVAINGNVATFARPNGEAAVTKEFHLLHVVPKMGAPTFIKDSGIGNDAGYVDVDDHSLRHRKYPNIWSAGDASSLPTSKTAAAVTSEAPVLVRNLLQVLQGKQPDAAYDGYTSCPLLTEYGKVLLAEFKYGGEPKETFDDWLGIDQVEPRRAFYHLKKDFFPWVYYASMVRGTWGGPKGWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z226</accession>
    <name>A0A7D5Z226_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cys-Gly metallodipeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dug1</name>
        <name evidence="6" type="ORF">G6M90_00g011840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549338.2">
        <property type="nucleotide sequence ID" value="XM_014693852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z226"/>
    <dbReference type="GeneID" id="26238782"/>
    <dbReference type="KEGG" id="mbrn:26238782"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="217"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="641" mass="70513" checksum="2BF6AF264AD6D539" modified="2021-02-10" version="1">MAPQLDSYFKQVDDSANHFIERLRKAVAIPSISAEDARRPDVVRMGEWLAGELKSLGAEVELRPLGKQPHKEHLDLPPVVLARYGNDKNKRTILVYGHYDVQPAEKSDGWATEPFELSVDDKGRMFGRGSTDDKGPVLGWLNAIEAHQKAGIDFPVNLLMCFEGMEEYGSEGLEEFIQAEAKKYFADTDAVCISDNYWLGTEKPCLTYGLRGCNYYSVEVSGPGADLHSGVFGGTAQEPMTDLVRILGSLVDTNGKIQIPGIMEQVAPITKEEEGLYDGISFTMDNIFESLGSKTTIHDDKKNTLMARWRYPSLSVHGVEGAFSSPGAKTVIPAKVIGKFSIRTVPNMDIDTTNNCVYKYVEEQFAKLNSKNTMKVYAQHTGKWWAASPKHWNFSAAAKATERVWGVQPDFTREGGSIPVTLTFEEATGKNVLLLPMGSSTDGAHSINEKLDKRNYIEGIKLLGAYLHYVAEEPQTVLDEFVPDRLCASLTGCIIGRCASQIDIQNSTTPLSASGSRQNGPETQHYQHLSNTAGLPKFLAAKFELYLSPTAVDAWLVVDGFIKSSRLGRLVDTDNTLQQPAGTWPGRQTPNFGAFLIAQRPRYPSLHDLLDGSGPHIANHLERLYGPLWKGLPGRAATPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2C0</accession>
    <name>A0A7D5Z2C0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g063780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986775.1">
        <property type="nucleotide sequence ID" value="XM_066130765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2C0"/>
    <dbReference type="GeneID" id="26244456"/>
    <dbReference type="KEGG" id="mbrn:26244456"/>
    <dbReference type="OrthoDB" id="4941163at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="323"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="597"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="680" mass="73151" checksum="1B572E7A828951FD" modified="2021-02-10" version="1">MRYQSITPILFAQYVASATIRPGPRTIPSLDSALGLGLGPRQYDEPFSEQLSPGSFSPGPSSFSGPSFPDQSPAGPSFPGSFIPDQSLPSQSLPRPDQSSPNQPFQPEPFQPQPIPVETRPDERPSNSPPPADPFSLNPFLVETPAEEKPPTKPAPAEPFPVKPLPEESVPNQPYPGQPFTPNPEPTLPEPTLLPKPEPEPEPEPVFTFSPTTISKPQPKPTFLPEPELETPLMSTTTQILTPEPAFTLKPITTLALETETESPLKDYLYIEINYDFNKFNYNFNNNLNYDIHYYLSYNLNSKSMVVDVLHSENREVGIPFQPMISMGFGTPSQVITGVLDTSSSDLIIPRAGSAACKLAKQQCQGSNAALGDYEPSKDSDVRRVPNSGFAAGFQNGDAYNGPYISTSVSVGDAKIKAAQVGLAVNGSVSQNSAQYPIFGVGPVDAEQTVDNAKYANLPQKMKDVGLINANLFSVWFNPTPFANGSVVFGGIDSTKFTGQLQTVPMERDNSGKISGFVVRLSSVQLSMSGARGGQRNGRPRTRQSTSIDLGLGQSEGFTSMNTGSSFILIPSGSMENLARALDTTFSEKDGLGLVNCQLASGDNSLIFGFNQGRTMLSVPLARTVISKEISKTSQTGGCALAIASAGQDNAVNVMGYPFMSAVYTVFDRDNERMMFAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2I2</accession>
    <name>A0A7D5Z2I2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g016840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548847.1">
        <property type="nucleotide sequence ID" value="XM_014693361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2I2"/>
    <dbReference type="GeneID" id="26238291"/>
    <dbReference type="KEGG" id="mbrn:26238291"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="21409" checksum="ADAE7996AAF981B4" modified="2021-02-10" version="1">MPSSKSGHSNHNSHQPHKGEEDGDRHGGKPARKSEETETQGDQAEATRIHLSVFIFRGAPDVWYRRHVIMYFTSPDDPGFHKSVHVQRDNERDPWRVALENGQAHWELDASYLGHVDAGYIPVWKGQEAWPLSTVASVQVEGREADWNCQNFVYEGLQAIVHLGLQEEAWYIWVQDEIMNQLLEGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2P5</accession>
    <name>A0A7D5Z2P5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g086570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542457.1">
        <property type="nucleotide sequence ID" value="XM_014686971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2P5"/>
    <dbReference type="GeneID" id="26244971"/>
    <dbReference type="KEGG" id="mbrn:26244971"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="208" mass="23530" checksum="5A9F3939A912E231" modified="2021-02-10" version="1">MSIQRVPLRLIGLSRLELASRTPAQRNLAIRWSSTSPATIVDTGFWTSLIPKPLRRENRKGIKGRKSKEWNPATFFIVMFLFIGSMSIQMIALRNQCERYNRQSTVRIGQLREALRKLQNGEEVDVDKLLGSADESQKDADWEEMLKTIERDEASQKALVSENVKQPEFPAKTIMSAAPMSDTEADDEQGNADMQPSKPKSANLGNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z326</accession>
    <name>A0A7D5Z326_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase ACTT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ACTT3</name>
        <name evidence="2" type="ORF">G6M90_00g059830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544552.1">
        <property type="nucleotide sequence ID" value="XM_014689066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z326"/>
    <dbReference type="GeneID" id="26242964"/>
    <dbReference type="KEGG" id="mbrn:26242964"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF4">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01890)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="300" mass="32909" checksum="FB6CDA2E4A754197" modified="2021-02-10" version="1">MASLPESYEKLSFPTLLISHHPPSSPSPTPIIIVKLHRPSHRNGFTDIMADNLVTVFNTLSLDPRVKAIILTSSDTQNKMFCAGMDFSSPQGVSTTAELHRDGGGRISVAMYRCNKPVIAAINGHAVGVGITMTLPANIRIASSEARIGFVFGRRGFCLEACSSFFLPRLIGTSKALHLTTTGAVYPANHKLFDGLFSEVVPPEEVFPTALKIAEDISVNVSNVSSRVMKDMIYRTTSSPEEAHLLESRLFHGLFRGKDAKEGVESFMQKRQPDFKGTMEDGLPHYPWWTPVDVKPPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4H3</accession>
    <name>A0A7D5Z4H3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545171.1">
        <property type="nucleotide sequence ID" value="XM_014689685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4H3"/>
    <dbReference type="GeneID" id="26242512"/>
    <dbReference type="KEGG" id="mbrn:26242512"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31148" checksum="6C189B66F6626F62" modified="2021-02-10" version="1">MLIEESHVDVPTSANGKDSTMRIFVFHPAIAGYPKARFPGVCLFSEIYQVTGPVARFARQIAGQGYIVAAPSSYHDFVGPEPLKYDVEDTDRGNKFKIEKASSTLESYDADSHATVDYLLSLPTCTGLIGSTGMCLGGHLAVRAALDPRINACVSYFATDIHSRTLGPYTAANSSPSAPANSNHTIDHLSRLGGEVAMIFGIKDTHVPDQGRDLIRSKLRDAGCVFSFHEFAWAQHAFIRDELSKGRYDPAVTKICFEILLELFGRVLKTDLGQKDGNVAPPEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Q4</accession>
    <name>A0A7D5Z4Q4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g040210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547370.1">
        <property type="nucleotide sequence ID" value="XM_014691884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4Q4"/>
    <dbReference type="GeneID" id="26239933"/>
    <dbReference type="KEGG" id="mbrn:26239933"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="380" mass="42349" checksum="07F4B205193F4D97" modified="2021-02-10" version="1">MSRITRVRRLASLQLAIATPSSAPRAPFVACRAVSTTRAARSKNTEWVRTKLWKGEAPGLEDPYTQRPEPEDPSNLPEEALEFQPRTDKTPAAVLESRLTLPPKRTEAASEKELTSSDPTYVPATEAEGLEEIGTLNTWWDQEGHWGEESEFRGFGSAEKVVDKDVVEVYLRQAVVEALALRETGAFSQWATKKWREGPRSELDQVLAAEIQVQGSQASLKGDVAAIAQNLTAESDEMEATERIRPEEAREMLKTWDASWKGLVLDDQLKFALRKRLYQLTGTLIADAKLGAAHTVRHVLTLAAKQPQPKKLAELLETRSDVQELANVKVHSRKIGPIDRETALGRWKVIEEELTKRGLPVTGTAGMSKNKERDWISGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z579</accession>
    <name>A0A7D5Z579_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g059860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544555.1">
        <property type="nucleotide sequence ID" value="XM_014689069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z579"/>
    <dbReference type="GeneID" id="26242967"/>
    <dbReference type="KEGG" id="mbrn:26242967"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039156">
        <property type="entry name" value="PHAF1/BROMI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465:SF2">
        <property type="entry name" value="PHAGOSOME ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13465">
        <property type="entry name" value="UPF0183 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="56304" checksum="ABA6814FAFF15BD8" modified="2021-02-10" version="1">MSLFTAQLYPGRALGFLILGASLHDVLTRLKAEPQRFPRLEVLHSPDRPVTEPVCVVLPQNGLRLRFDGPEQRLRLIEVVDFTKIHITFKDRDLLKHTTNGTSAPGSPVPGESPLGPTFRHIYHRLLGPTYAGEFIPPSSGQEDGTYVLSYPGVAFNFSLAKSAYSPDKDVVTLLSASSSQVATSMAVFSGTSWAEARQTLWTEILPSVKQTSVLPKTKDVYPDEVSLIRIHGGGKLDLFRKWTNNAFRIQLGETTPQELVMELGPPNAIYRKNDQKMVIHKMRAASSSRGRPSSSDIGRPDDLTDTDQSSMNTGSDDSDNDEAIDEQTASNPLEECFYNYFYLGFDILLSLPTQPSAVPPADDTSEDPAENPIKHHHPDRLVATKVVLHGNVPGSYEFNRHRRCRWEIAYLDDVTSETQFKYVEEGMNSKWEGAYSLGKVPQGQRGMVLNRGWGDSPGSSCEFLGGWEESGAKRAEANGDSTTTLYGFPGLVFEVLRNDYVNTVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5J8</accession>
    <name>A0A7D5Z5J8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclochlorotine biosynthesis protein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g081480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5J8"/>
    <dbReference type="GeneID" id="26243563"/>
    <dbReference type="KEGG" id="mbrn:26243563"/>
    <dbReference type="OrthoDB" id="4936991at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22784" checksum="33320EF292C0D489" modified="2021-02-10" version="1">MAPKLTPSTAPAQDAIHYEVKKFHRGFGDKKTAYQGDPSPEVDKVWKSLYNEIGISRLSREQAQLLPNRTYPFIGDEGYYIAELAVFHQLHCVNAIRIALSKDYYQTVFSLEEFDDAQGSYGRDHISHCLDAVREAIMCASDISVITWQWNDQAEKALGHGDVLHTCRSFEKIKEWAAENQALVDFNADVFVKGDPVVDGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5P0</accession>
    <name>A0A7D5Z5P0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">X-Pro dipeptidyl-peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547813.1">
        <property type="nucleotide sequence ID" value="XM_014692327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5P0"/>
    <dbReference type="GeneID" id="26240376"/>
    <dbReference type="KEGG" id="mbrn:26240376"/>
    <dbReference type="OrthoDB" id="5959877at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361:SF2">
        <property type="entry name" value="DUF885 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="GLR0591 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="66220" checksum="64762B292D3BDBD4" modified="2021-02-10" version="1">MAHHLGTPPSGMNMESVWVSLPKPSSDGTESTADRIRRVQADLGEIYTFYNISISPTRRSRLDRFCADELESLSHVEFDALNQQDKVDYILLRNFLRQCRARLKSDQDADKSRAPLLPFAAIIVSLCEHRERVKPIRPEHIASKLNDVKKLVDKVHQEVEDGKVKTSKTNAYKASKVISELRSHLAEMFKFYSSYDPQFDWWATSPWEAVDAALEKYFSLVQSKLAGIRPDGKGDIIGQPIGREALLNELEAEVIAYAPEELVQIANQEFKWCEQQMKLASTELGFGDDWKRALEHVKTKFVPPSEQPQLVMQLARQGADFVRDNDLVTVPPLAEETYRTIMMPAEQQKVSPFFLGGSMIQIAYPTNDMPYDLKQMVMRGNNRHFSKATVFHELIPGHRLQLYQAERHRSHRLLFQTPFFVEGWAMYWEFVLWQRGDFFVSPEDRIGTMFWRMHRCARIILSLNFHLGKMEPQECIDILVNWVGHERSTAEGEVRRWLNGDYGPLYQIAYMIGALQLVELRREVLTSNRMTEKKFHDTILTYGAIPNELVRALALDLDLKPDYKAKWRFYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5Q0</accession>
    <name>A0A7D5Z5Q0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g111560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543709.1">
        <property type="nucleotide sequence ID" value="XM_014688223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5Q0"/>
    <dbReference type="GeneID" id="26243096"/>
    <dbReference type="KEGG" id="mbrn:26243096"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="310" mass="33648" checksum="B50EB7546847FED8" modified="2021-02-10" version="1">MAQKGQGRKIAIIGASGQVGKPTVNTLISNGGHTITALQRPEATSAFPSEVIVKKGNLEDETFLTDALTGQDAVVLMPPLSLLAKLQEPAIRAAAKVGVPYVFPSEFGPDPFAGKLVEENGLLVAKKKIRNLIEELGVSSWVSIAVGPWLDDGLKGGLWGIDYKARKATLWRGADAKVSTASIAHAAEAVAAVLSLPEADLARYKNKAVYTPSFHLTQRDILQAVQRATETTDADWDIRVRDVKDVENEYEEKIRQGDGVAPYVKFFVTHFLQGHGGDFQNKVDVVELEKLEKLGLQRESLEQAIKKGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z620</accession>
    <name>A0A7D5Z620_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumagillin beta-trans-bergamotene synthase af520</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">af520_0</name>
        <name evidence="6" type="ORF">G6M90_00g031200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986398.1">
        <property type="nucleotide sequence ID" value="XM_066130083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z620"/>
    <dbReference type="GeneID" id="90967588"/>
    <dbReference type="KEGG" id="mbrn:90967588"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="258" mass="28209" checksum="E145492FEDFCB573" modified="2021-02-10" version="1">MQMAVALVLAGPASLSVIAKGFIWNQLHLLTFQVKNQIDGVEEDRIAKSHRPLPSGRISPENAAVLYYVLFALMWAAALTMKTIPCTLTYSVAILIYNEGGLAAIPVVKNVIGAIGLACYCWGTTIILDHGRELYGLKAIAVFMIGAIFATTGHAQDFRDRTADTVRGRKTIPLLLSQPAARWSLAALIVAWTIGLIALWQPPAVASIVFAALGLRCLGGFLSSYDEKYDYVSYCWYGYWLLGGNLLPIFPRLRGEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z637</accession>
    <name>A0A7D5Z637_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g098440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546500.1">
        <property type="nucleotide sequence ID" value="XM_014691014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z637"/>
    <dbReference type="GeneID" id="26240923"/>
    <dbReference type="KEGG" id="mbrn:26240923"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028863487" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="43322" checksum="C05EF06E1638E401" modified="2021-02-10" version="1">MQNPIPVSSLPATGRLFVLLGATAAIVSASPFPRNAVNDWGFSFLLRRDDCATYCGSEKQFCCSSNQVCTTLAGNVATCAPGGGGSYGAYTTTWTETRTYTSTIMTNWAPAPTPIPGVDCKPQSPEQEACGSICCAGWQTCAFKGQCSSRPGYQEPSTIVITSDGVVTTRYSAPYRVTGTTTVIGSGTRSDQSFFTATATTTSAGATSTSDGDTIGADGSNKGGTGGGLSGGAIAGIVIGTLAGVALLMLLCFCCIARGIWNAIFGRKKERSEKVIIEEDVRYSRHGSQAPSAYSRRDRHSGWFGGRPTSVADRRPKKSDGKWWLGLAGAATTLLALLNLRKDKKPARRPQSSRYTDSSSYTYSDVTYMSPSSSSSGRRTHRTGRTGRSHRSDSRGGASYYSRATTRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6E9</accession>
    <name>A0A7D5Z6E9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TUB1_1</name>
        <name evidence="19" type="ORF">G6M90_00g102590</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546089.1">
        <property type="nucleotide sequence ID" value="XM_014690603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6E9"/>
    <dbReference type="GeneID" id="26240512"/>
    <dbReference type="KEGG" id="mbrn:26240512"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="50"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="18">
        <location>
            <begin position="249"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI72983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="453" mass="50362" checksum="D7D6CD2E426A8F1B" modified="2021-02-10" version="1">MKGEILHLHLGQAGVQLGNSAWELYLLEHGLGPDGRPDPNAKDVGDPGSFETFFTETSNGKHVPRSIFMDLDPSPIDEIRTGSYRQLFHPELLISGKEDAANNYARGHYTIGKEMVDTVMERVRRVTDNCNSLQGFLIFHSFGGGTGSGFGALMLERLATEYGKKTKLEFAVYPSPRTNTSVVEPYNAVLSTHSTIENSDCTFLVDNEAVYDICRRNLDITRPSHEHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPYPRIHYPLISYAPVVSASKSKHESFKVADLTFQCFEPNNQMVVCDPRNGKYMAVALLYRGDVVPRDCTAAIAQVKAKASFNLVEWCPTGFKLGINYQKPMAVPAPAEDGALASVERSVSMLSNTTAIAEAWSRLDHKFDLMHSKRAFVHWYVGEGMEEGEFTEAREDLAALEKDYEEVAADGIDAEEELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6G4</accession>
    <name>A0A7D5Z6G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g050380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545145.1">
        <property type="nucleotide sequence ID" value="XM_014689659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6G4"/>
    <dbReference type="GeneID" id="26242486"/>
    <dbReference type="KEGG" id="mbrn:26242486"/>
    <dbReference type="OrthoDB" id="10275623at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10095" checksum="E08303B3A9628643" modified="2021-02-10" version="1">MLLKKRACLITTQAASSVSPFEPRQGITKGGKSIKFKVNMDKGRQGKTGCNGVVFAETVTFIDKGNMPNIADAGITENHAGWRRLSTILALLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6T4</accession>
    <name>A0A7D5Z6T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g111030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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            <strain evidence="2 3">4556</strain>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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            <strain evidence="2 3">4556</strain>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="298" mass="34483" checksum="32DB0CD3361A39D5" modified="2021-02-10" version="1">MAATTFHRFARLPAELRRQIYVEHLSPLDAPAVYLYNKNLVLRYLDPDSEDERYAGISHEPRVQVKTPALVHVNVEARAVTMSWARTHDISLGFRRETKGHVFSRPWDPTRDTLYVSRDKWEEFCELPWESKGVEEMSAKVRHLALPAFTAYYSFNELGNYVMQWFPSLEVLSSVWGPLPELKYSRTKRVSRRQLLAAGATDDDGTDTGVDPLTGDREERIAAEIQPMWELVRETKDVVRMCVLDPLDETESWEEGELQMWMEELADALLTTELPENVYDVEGQKYSIEFRPVRAVKG</sequence>
</entry>
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                <person name="Kouvelis V.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">4556</strain>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
    <sequence length="87" mass="9167" checksum="E9394EB16014E864" modified="2021-02-10" version="1">MAQGAIKQSTKAKAPKATHSKKQASKVNKPQKAKTSLEKAHKKFSAGLTAKTEALLGERAGHLELIGKGKKGKDKKVSIKGGSKKFG</sequence>
</entry>
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    <name>A0A7D5Z925_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
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                <person name="Kouvelis V.N."/>
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            <strain evidence="2 3">4556</strain>
        </source>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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    <name>A0A7D5Z9D6_9HYPO</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DUF3605"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="213" mass="24915" checksum="1008FC90CD8F8AC9" modified="2021-02-10" version="1">MGDNVANSQREEASFPLTDVDKWVLSQTDDEFQKHDWEDLKQVIETNNLSVLKRVPSDLKRYIKWTTETKAQYGSMTQYLLANRLPKSWGQPPFSPESDVPFDKESDYKVLLNDWPYGLESNITHIVVWTRTFIATDDDKGDMTPESRALVKAFVKRYFIDSLGEGGEDKVLWFKNWVALQSVRALEHIHVLVRDVDDDMLERWSGERPRRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA30</accession>
    <name>A0A7D5ZA30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase acuF-like C2H2 type zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g094500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540815.2">
        <property type="nucleotide sequence ID" value="XM_014685329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA30"/>
    <dbReference type="GeneID" id="26246428"/>
    <dbReference type="KEGG" id="mbrn:26246428"/>
    <dbReference type="OrthoDB" id="4941462at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase acuF-like C2H2 type zinc-finger" evidence="2">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="609" mass="70226" checksum="3BD4E0E1504E53C7" modified="2021-02-10" version="1">MEEATSGHASQLVVQAIRCQNILKDLLSNCEQNDVGHQKSNFLSTQSARLNSWCGKTGIYESGQHSLDYHLKGLPQTKITITKLLWELSLCLQKLREPESIDEHATSKMQSQQECDEDSDTSEWSRDSLPVSHDRNTHPQPNRKWTRIERNIHRLYMQARLDELDGENDMQTRIERFKNEPGQNQVYELFKTMAREKAEHQFPRSPLWMQERIAESFARRRMRFEYLKHHQEKLACGLHHESPPQPQNDAAGTTLTTFPESDTQVNKPDSQNTTSRAGNRGVILSATENTRLDTISSPRTTESVASLTMGHHDLPYRPKLQESDTFTCPYCFLVIPSTEAEGISWSQHVMRDLEPYFCVFKDCSKPFEVDNSFDGVLAHMHDSHVAVPYWMSMPDGSRQDFKNRHLFEQFLEQEWHLPRSGFDSLRAIFRRKEGFRFPTCHFCGCYPDKFRKCFRWDIPFAQEEMRKHIKQHMEEIALYLLPVMDDVVDDAPGENNMSDDAVGTQHHGLDELSAVPWRTTPQQEHRDSEDRMESTNTVDGQLQSDFEMEAQPNHPGKKNDGLERSQENTNGDKSAQGRVAWSDWSKGPSSSSPEQRTKARISSYTGSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAF1</accession>
    <name>A0A7D5ZAF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein 6, OR allele</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">het-6_9</name>
        <name evidence="3" type="ORF">G6M90_00g082640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543490.1">
        <property type="nucleotide sequence ID" value="XM_014688004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAF1"/>
    <dbReference type="GeneID" id="26243667"/>
    <dbReference type="KEGG" id="mbrn:26243667"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="63"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="596" mass="66722" checksum="73298167AFA1FF58" modified="2021-02-10" version="1">MSSTASANATGQLPVVPSEPYASRPLSTSTDTIRLLTIERELSNQGYLVCSIQVAAFSPPQKYEALSYRWGDESVQKTIIVDGISVTVTENLHAALQYLHAHPRGCPLWIDAVSINQKDVPEKSRQLRIMPHIYSRAASVLVWLGTQYTTVDVDVESHLQQAIQDVNGDEYWQRVWILQEIGKARKIQVCFGSAGPLDWDCFVRHVKKHAESKERNIGPLALQAMRRNKYSGSCSLKRLLENHLDALCKDPRDKIYGLVGLSVDGRDFPIDYSKSVLDVWADTVHFMGRKNLLPERNDEKAAFCTLLRNLLGGDNMPSLGGVVQFQHKPGSQSLYDHLRAEGRDEWAASSVELATTCLGRIISVGPAISELRASLDLTDKWEAELQRVYRNEYEDVLDAAHQEHDVLMQHILDDTDSKLPGLTCFENHRIDFITTDHMHSLYPYSKYDPDGSDEDDRISPEFEGSWNYASAISDEPRLAIVKESSSETLPYKIAIVPPTARLADFICRVQGAPMKRIVLRHDYGSWTTQHVCGTAVMMKDLMGETAALGAEASEVERIEGIFTQIVRMDARAFYALIFGNDDGIQELKDKLGALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBH2</accession>
    <name>A0A7D5ZBH2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Minor extracellular protease vpr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">vpr_3</name>
        <name evidence="15" type="ORF">G6M90_00g092570</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541901.1">
        <property type="nucleotide sequence ID" value="XM_014686415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBH2"/>
    <dbReference type="GeneID" id="26245369"/>
    <dbReference type="KEGG" id="mbrn:26245369"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028914901" evidence="11">
        <location>
            <begin position="20"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="154"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="380"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="616"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI72069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="885" mass="93067" checksum="56BB2FB3C15C6141" modified="2021-02-10" version="1">MVGLSLVVSLVAAAASALAADAQDDKVVKTIVPGAYIFELEAGHDPAAFEQTVGKDGTTRMKLDYELFKGVSVQLHDVDKAHEKAAKLADTPAVKAVYPVQLFNMPKPKVEWIAQDGTKAPGGLLSSRADDGADTFSPHVMTQVDKLRAKGITGKGVKIAVVDTGIDYKHPALGGCFGEGCLVAFGTDLVGDAYDGFNTPHPDPDPMDCGGHGSHVAGIVAAQPNTYGFTGAAPGATLGAYRVFGCKGQAGNDVLIAAFNQAYQDGANIITASIGGPSGWSEDPWAEAVSRIVDKGVPCTVSAGNEGAEGIFYASTAANGRRVSAIASYDNVQTPTLIYSSQYQVDGDADTKFGYVPSDPASWDGVTLPAWSNSLDPTIPDDGCDAFPANTPDLSKYVVLIRRGSCSFAQKVNNAVAKGAKYVIVYNNNAVGAIPMDLTGVPAGSIKAASMIDGTTGATFINALKDGKKLTLKMVSPQKTDSEVSTSNNTVTGGALSTFTSWGPTWEMDTKPQFGAVGGNILSTYPRALGSYAVLSGTSMSCPQTAGIIALIHEVRGTYDPELIQNLLSANANPQLFNDGTKFYDFLAPVPQQGGGLVQAYDAAYATTLLSPSSLSFNDTDHFVETLSFKLQNTDSKGITYKITHTPAMTMYALGDGSPSVQQFPNVAVQAVATIKLSETSVTLNGGQSKSISVSPTPPQGLDAKRLALWSGYIVINGTDGTSLSLPYQGLTGSLHNSAVLGANNTWISKSTDKKSNPVPPNSTFVIPAPGNAGSNDTLPQLTVELYLGSRKIRADIVPLTTCPPKNLTTEFQGIKTIGQPYNFPALWGTRGLNTFPWDGRLDSGNYAPPGKYKFVVRALRIFGDEKKKDDWDVSTSPALHIKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDA1</accession>
    <name>A0A7D5ZDA1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g096030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546728.2">
        <property type="nucleotide sequence ID" value="XM_014691242.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDA1"/>
    <dbReference type="GeneID" id="26241151"/>
    <dbReference type="KEGG" id="mbrn:26241151"/>
    <dbReference type="OrthoDB" id="640151at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="498" mass="55420" checksum="85D78A00489CE1BA" modified="2021-02-10" version="1">MPQHHRIAPAKCPPGYFWGEDGQNVPEKIHDGYREARRLIQDGSLGDLESLSEAAMLRITEAFDSLKSPDGTSKGSLVKLRLSDDLEQWRREQHALGRILPSKGHGLGSVSKEALALLGAQTWPEPLVQNNTLFISGMANMLIGASDAEALYTNYCLDVAFFYEHGYHKVFPGFEDLVQAQLHSAGGSERKAAVNIGMRYIRAKVALEEAHKEQASDMMAKLDRRSAQIVFFLESSILGMAREAMMRGFDRAAVMSDLIFSSPGTDVIDVGSDLYNCELWNSFLNTADITSTGVVAEEALRKVYDAYAHTGARMLCERWSEPAARLSAMLYPWHMVNDRHRFLRRALLGFPKARKGAAQPREADFDEVFDLELRTTGFSRPLKEACSVGEPCDQVEGFLGAHDRGEGVLAELWWSLVTGPVRYVARGVVGPAEEEDLAERLRLSMARSYSHGLVDEMTWLIAHASHHAWQVNRLFEAAMFGSLLDDGGLRGKLDRKDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPR1</accession>
    <name>A0A7D5UPR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">rio2</name>
        <name evidence="17" type="ORF">G6M90_00g022210</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548333.1">
        <property type="nucleotide sequence ID" value="XM_014692847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPR1"/>
    <dbReference type="GeneID" id="26237777"/>
    <dbReference type="KEGG" id="mbrn:26237777"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000566">
        <property type="entry name" value="Serine/threonine-protein kinase rio2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="67"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="341"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI63895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="420" mass="46986" checksum="404FE54DD7FB6C80" modified="2021-02-10" version="1">MKLDTRAMRHLASEDWRVLTAVEMGSKNHEVVPTPLIEKIARLRGGASGVRRSISALAKVGLIARVKEAKYDGYRLTYGGLDYLALHTHASRKDLYSVGNRIGVGKESDIMVVADQTGTQRVLKIHRLGRISFRTVKSNRDYLKNRASGSWMYLSRLAAMKEYAFMKALHEEGFPVPVPLAQSRHTIVMTLVDAFPLRQISDVPDPASLYADLIALILRFANHGLIHGDFNEFNILIKEEKTVSESGEESLKLEPVVIDFPQMVSTEHQNAEMYFDRDVECIKRFFSRRFHFTSTTPGPFFKDSKKKLAKGGFTRLDATVEASGFTKKMLKDLETAIKDQVTKRGEDGVSEEFDDDDDDDDEVGSEDDDDKSGDDEKDDGGILGPHSHERTLSTGAKVDDEWSAADAQPLLNEDLSKLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPX1</accession>
    <name>A0A7D5UPX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547857.1">
        <property type="nucleotide sequence ID" value="XM_014692371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPX1"/>
    <dbReference type="GeneID" id="26237301"/>
    <dbReference type="KEGG" id="mbrn:26237301"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="585" mass="62754" checksum="875726397CECDE81" modified="2021-02-10" version="1">MAAPNTHIRGSVKDILLASILSSVPLVVLSAILLGLVFRNRVYPSSPLSDIQGAAASENDDSVIYVNLSATTLTALASWSSTIAPLTLTYILSLASFPAAREMIRAAVNTLRSGSGTLTPYQLSLMLRMICSSYLNSVWYCISYIAKWRKRAPIARSVVVMIWILMLSSLLSALVFATDSWLHFTTKSVTLTQFEPVSFDDASFGLHQNCTNLTESFTAQCDLNPAGSTTFLWNAEESLNLLANISTRGMVQPVSDDAGNQYAYIGLPVSLSKSSVDYVATSLAVQTKCAPITTRCFNATSTISGPSAKYSCDFAMQGTISTTFINSMNMGYFTNSTLSDTIPEKTPMSNPYYFAAVVSANQNVGLNQDLIHDPEIKSGEHGSVLFVVLCNATVFDMVYTSANSTVTQVSVLESNSSTTSVVMGTQAYTHVGDTYILQRTSLDVWQSHSAQEIASKFAHTYSEIALAASGAALEPGPAVEAQLRSSMIVAKVPKAPLGCLVAANLLLAVLGILLTVIALLVLNNDVGDVKARLGIPALVATHFETNGGDEPVKNIEDMFEEFDGRAGPRVVAAKTALGCWRLERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQM6</accession>
    <name>A0A7D5UQM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g009100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549600.1">
        <property type="nucleotide sequence ID" value="XM_014694114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQM6"/>
    <dbReference type="GeneID" id="26239044"/>
    <dbReference type="KEGG" id="mbrn:26239044"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="144"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="323" mass="35893" checksum="721AC114DA1686F4" modified="2021-02-10" version="1">MAVAAAQVGSPQQQPSLLHLIALVDNVPIDFETNCTPYYRLQLAPDPRTHGYIHPNTVNSMPWPASFTINHDTRQVTLSPPSPETSLSLSAHANAAFQAAIDAAIDGNMFPMLNGMHSEHFLLMGAREFVQIERFAASLFGIATRGAHLTCYVRAPDGLKIWVAKRSPKLFTYPGMLDSTVAGGVKADNSPLDCILAEATEEASLPADLVARLVRSVGVLTLANRNPRTELHHSEVLYVYDMELEEDIVPTPQDGEVEEFVLMDCAELRHRMFNGEFKPNVCPIMIDFLVRHGEITPEGERHYVEICNRLRRRLPVPTVPDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQN9</accession>
    <name>A0A7D5UQN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General transcription and DNA repair factor IIH subunit tcf-29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tcf-29</name>
        <name evidence="10" type="ORF">G6M90_00g008050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985762.1">
        <property type="nucleotide sequence ID" value="XM_066129642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQN9"/>
    <dbReference type="GeneID" id="26239147"/>
    <dbReference type="KEGG" id="mbrn:26239147"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="9">
        <location>
            <begin position="151"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="BSD" evidence="9">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="647" mass="71507" checksum="DCC79F602A1293BA" modified="2021-02-10" version="1">MAAPAGRTLFKKKDGILTLTDDYQIVTWTPNSGGPPTISLPVSNITNLQQTPETAAKVMLKIFEKADNGADPATYLFHFNTAEAKAEAKAVKDVLSKILADMRSHDTGVPRPNVATPTAGGASTPAAAGSGSAAMAFASAVNSQASSSTRWFDDNQLKNDIELQQSLMKKDKSLHQTYVEAITTKPESISGAAFNSQFWSTRTNLLRAHAIEINQKKGAYNVLSTVKPRTVDGELKLNISVEQVQMIFAQHPLVKRIYNENVPKLSEADFWSRFFLSRLSKKLRGERITDNDTQDPLFDKYDVTENTEGVQSKIMAQSVPHIIDIEGNEENQGGFKGGNAKDVEMRPRANIPIVKTLNSLSEKIMANVAPSDVYDDNGSRERDEFNELALRDLRGNTAEHRIMLNVKEQNRFFQKQDSAPSENARVFATQKPKEVLSKIRNTLRKFETDSSDGASLQAAIAFEDESDSDEESQKHIQVGSRAAIKVAEKEVMEGVLQQRAQKYGHSTDATSPMGLPPSMTEKCTLTHATSIEFLHQFWTAFLSGDPDRAAELQYLAESLKRSAARVSAVAEEAEKERESVIRQRKQEIRNHFERTGKKIRWKSDMVGGGRDAVIKLMQPVLDALDKAQAEYSRALAAEGIQISTEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQU4</accession>
    <name>A0A7D5UQU4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g023580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548197.1">
        <property type="nucleotide sequence ID" value="XM_014692711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQU4"/>
    <dbReference type="GeneID" id="26237641"/>
    <dbReference type="KEGG" id="mbrn:26237641"/>
    <dbReference type="OrthoDB" id="4139606at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028872990" evidence="1">
        <location>
            <begin position="18"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="29710" checksum="45186C5DB536CFE9" modified="2021-02-10" version="1">MLAKILTLSSFVGSAISANNFRVFDSTAYTNTSIGYGTSNINWIPNYVCSPLVANNAIPSAETWQSIVLEWNIYPGYPLVLDCENIYLTSPSTADHNLEVMKTLQTWAAQVLPSDQIIGWYGLSGNTAASLYGHYRSLIANHSAHAFFPSAYTFSSSLTTWNASLNSVLAKIKAIDASLPVYPYTWPQYHGSPYAFYPVGLWKSQLDVLTGNQDINGFVIWGGKNHQVCGDACQASAGKNPWLEATRTYLKDLYGIYGGASQKQGGQLFTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR34</accession>
    <name>A0A7D5UR34_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor U2AF subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">U2AF</name>
        <name evidence="9" type="ORF">G6M90_00g012660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549257.2">
        <property type="nucleotide sequence ID" value="XM_014693771.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR34"/>
    <dbReference type="GeneID" id="26238701"/>
    <dbReference type="KEGG" id="mbrn:26238701"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="208" mass="24223" checksum="C94128B1A202BDCB" modified="2021-02-10" version="1">MANFLASIFGTELDKVNCSFYFKIGACRHGDRCSRKHVKPSYSQTILMPNLYQNPAYDPKNRMNPSQLQNHFDAFYEDIWCELCKYGELEELVVCDNNNDHLIGNVYARFKYEESAQKACDELNSRWYAGRPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKNPSEELDRDLTLSTKKWLRLRGRDERSMSRSPTPEASKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URS7</accession>
    <name>A0A7D5URS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein AIM7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM7</name>
        <name evidence="4" type="ORF">G6M90_00g022290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985874.1">
        <property type="nucleotide sequence ID" value="XM_066129892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URS7"/>
    <dbReference type="GeneID" id="26237769"/>
    <dbReference type="KEGG" id="mbrn:26237769"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="146" mass="16654" checksum="6EF6BA6C3CBB468C" modified="2021-02-10" version="1">MASESRLYTFSGETKEHLRKFRLTTSRAKDPQAVIYMIDKNTHEIRQALDDYDEARVYKSLKEVAEDLPDHTPRFVLLSYPITTSDGRLSVPYVLLYYLPITCNAEVRMLYAGAKELMRSTSEAGSVIDIESAEDLEEVPEKLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URW6</accession>
    <name>A0A7D5URW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-2-aminoadipate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lys1_0</name>
        <name evidence="6" type="ORF">G6M90_00g001280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985909.1">
        <property type="nucleotide sequence ID" value="XM_066129503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URW6"/>
    <dbReference type="GeneID" id="90967394"/>
    <dbReference type="KEGG" id="mbrn:90967394"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="154"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="265"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="35632" checksum="ED184D3725869668" modified="2021-02-10" version="1">MIFAYRSVELVIAFMGTLAAVVTITVLDPAYPPARQKIYLQDSQTKALISIGRAKGGPKAPGLDPSSSIISASGQCKRKSEVISNLSYQPTASQGTASSQKACLQTRTAKVDGPILPFPDAALISEEASEEDLKSWEGLISTNKDLAEQWVTLVCGLNANTLRLESDFFYSGGHGLLAQQLLLNIRQKMGTNVSIHSLYSNSSLKALSVQVDRPREGNDDTGAAEEGEPAFTQSLEKLLGSLDAKYRTADPATLTPERKTTVFMTGARGFLGCYIVKDLLERKNVEVLAHVRGTRDVQAALGRLKRPLSYRVWQDSWAVRPSAVIGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URX2</accession>
    <name>A0A7D5URX2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g029590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541212.1">
        <property type="nucleotide sequence ID" value="XM_014685726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URX2"/>
    <dbReference type="GeneID" id="26245847"/>
    <dbReference type="KEGG" id="mbrn:26245847"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="27737" checksum="6E00B6EA6EFF3F3A" modified="2021-02-10" version="1">MSTDHPVWFIAAASSGFGHEIALAALKRAHVLALDVTSPPSTIESVAAKVFEKHGRVDYLVIAAGFILEGAVEEVSRHTIAAFLPRLRAQPVAPDGVRSTIVTFGSLASWRGGAGFSIYAMTKACASSLAESLRDELAPFQIRAATVEPGYFRTSFLNAGVMVNAQNRIEVYSDEATPTGQLRKKLLAVDDNQPGDVVKGCKALVDVLTGTGLAHGKDLPVRVVLGPDCERVIRDKCSQRLGILDEWTDAIRSTDHDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US00</accession>
    <name>A0A7D5US00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pmm1</name>
        <name evidence="14" type="ORF">G6M90_00g012160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549306.1">
        <property type="nucleotide sequence ID" value="XM_014693820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US00"/>
    <dbReference type="GeneID" id="26238750"/>
    <dbReference type="KEGG" id="mbrn:26238750"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="271" mass="30008" checksum="9BE3DDB5DCFA069B" modified="2021-02-10" version="1">MAATKPSYPPLEERPLKDTICLFDVDGTLTPARLDASPEILSTLAALRQKCAIGFVGGSDLNKQQEQIGKPAGNVPVTTLFDFCFAENGLTAYKLGQALPSNSFIKWIGEDKYKQLVNFILHHVADLDIPVKRGTFVEFRNGMINVSPVGRNATTQERNDFEAFDKGAGVRRAFVRALKEKFPDLDLTYSIGGQISFDVFPAGWDKTYCLKHLEAEAQKPGGVAYKNIHFFGDKAFEGGNDWEIYSDPRTIGHAVKSPEDTIRILKETFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US44</accession>
    <name>A0A7D5US44_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/threonine-protein kinase srk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">srk1</name>
        <name evidence="11" type="ORF">G6M90_00g026180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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</entry>
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    <accession>A0A7D5USX9</accession>
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                <person name="Kortsinoglou A."/>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1239" mass="135766" checksum="D191C66868CFA3D6" modified="2021-02-10" version="1">MAAMRGPRLQVGSAGWITEERNAALQITQSEVDEFSYSARNELDWLNEHMANIFNENEINFAETFKTPAKLRGKTPRTARKANPLETRVPLSEVFSATPNGASSPISRLQSPGVHDDAARGSPSPLRPSPTRVPVFSQKSAMQGTQDSGYFGSQDVVPVNIHMDSDSYDGQDSLQQGAVQTTTIPLKNSPANASTQPSPEKTFQTAREDQTARVSADTSKKSIPKAQLNLHRESEYEDDVSPERQLSLEAKQGAHYPDDDARSASDGSSPIRPIVRKSSLNFASLPAREPLAAGKSNGARASRTSHLDHIRTSYYNRTTGGKSLGGNLTKPDRDENQENEMEVDDELPSHPITNQDNKTYTQRLQDQINMLGQSQAKNVQTQPQSKAPALKAVSPIPLNTLQSTPGAFPEDDDDDWIEPPATLAAANEERPSLPKSHSADVMEGIQGKKTIGETDFVMSDDDNAEVDKQFARPGKGNGAKHTYGHGKSASVPVVPNMRPAMEDTHYLKKVVSVSNPSLLTVAEAGSLGTFKSPSRALRESPLKQVKNKLSSILKSSRGLLASSAAISAEGKSLMSPTSTRLGLHSFMSSESVVSQQGTGSQASQSAPANQDASPTRLTRRTRASVEKEKEEKRREKEAKRMEEQNEKLEKARQKEREKARVFSKEQEKVAAMEMQIASKKEDERSAVKETPKSARTGHRNAKNSGEETTSLNRDVDMEDAPSMPPPSAPRSVGPTHATRNREIKRPFTRETQTRPKQAPTVIRVNTGSQHSQYRLSTAQPDVSSLSASQTQQQLTSKASKASLQLKQSTQSLRGAAPSSRAKAQEVAARKKEQEEKETQKRRDAKAEMERKKAAAQEEQRRQEQLKRQEAERQRKQQQQEQASLQSQSQTKGNAQRKAAIEKAKQTRAPPPAVRSQPNGPPDSAMGQDSQPARPQSRMTSTANWGQDELGRPVNAVLSNTGKAGSKRNFVQEKGDDGHEKRPQSRGGPSYQTNDAKRRRTSDAFDDEADASGQKNIMGPPVRPSAGFKKELPSKTVFQSGYTNAPHGATRDLFKATITAQHANQMKASHPLEMAQISKGAIPFAPNPNAAGPAYKTPARPGPANTAKSAAKSVTRSSPRFQNGEAIELPEIQTDDDSEDDEANGVVVAPWADSPDLRKALVNQETMDPSLIFGPPRPLNMEEVFSKSKDRWHKFRARTSSANWTGADRLTEDDIRKDMAARDKLRRDGGWSYEMSKDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT13</accession>
    <name>A0A7D5UT13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g017010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548830.1">
        <property type="nucleotide sequence ID" value="XM_014693344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT13"/>
    <dbReference type="GeneID" id="26238274"/>
    <dbReference type="KEGG" id="mbrn:26238274"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="94"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="398"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="619" mass="70272" checksum="5CDBF9B75A83EB3C" modified="2021-02-10" version="1">MAGQAPEHATEALAQLQLDEETGEMVPKRELKKRQQKRARKAAIAAARAEKPNNTPKQQLPPQEKTDGIQVDPDAMFTRGFLADVYNELPAERVVTRFPPEPNGFLHLGHAKAIAVDFGFARYHGDAEEKGFIDAIKETIRWLGYTPHAITYSSDNFQKLYDYAEQLIELGKAYVCHCNESEIKRQRGGHEGKEGPRYRCDHSEQDVSTNLVKFRMMRDGKYKPQTAFLRLKQDISNPNPQMWDLAAYRIPKDQTPHHRTGNRWNIYPTYDFAHCLCDSLEGVTHSLCTSEFVLSRESYEWLNKSLKVYEPMQREFGRLNLNGTIMSKRGLSALVEDKIVRGWDDPRLYTLVALRRRGVPPGAILSFINELGVTNSRTFIQVNRFEQSVRKYLETTVPRLMLVLDPVALVIEDEIDPGISERRIPSPTSELNGHTQRLTQTLFIERSDFREADSKDYFRLAPGKTVGLIQSPYPVKVVSFSKSPTTGIVTEVRAVFDKDCKKPKAYIHWVPEGSRAVEVRVHAPLFKSDDPMQTEGGFRNDIRPDSETIYPGALISSGFDEVRKTAPWPKVAANNEGSAPESVRFQAMRTGYFTVDPDTTDDHVVLNRIVSLKEDSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTX8</accession>
    <name>A0A7D5UTX8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">20-hydroxy-prefusarin hydrolase FUS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FUS2_0</name>
        <name evidence="2" type="ORF">G6M90_00g035830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546978.1">
        <property type="nucleotide sequence ID" value="XM_014691492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTX8"/>
    <dbReference type="GeneID" id="26239541"/>
    <dbReference type="KEGG" id="mbrn:26239541"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="44584" checksum="571C38E3E56D0EE2" modified="2021-02-10" version="1">MAHLLNHFFPSNESFGYEAIRAAGYATCGAADIGEIIAICHNIPAGDEDLWLQEWKAAADRAVANANTSLSRGNTVGARDAFLRASNYYRTAEFYRRQDPHHDQVASAVADASCDAFYKAAALMPHVTTRIAIPYEGTTLPGVMMRPDAGHEPRPLVIVNGGYDSTMEEVVYSVGAAALQLGMNVLAFDGPGQASAVRKQNLCFRHDWEKVVTPVVDYAISQPFVDSSKLVLVGLSMGGYLAARASAFEHRFAAVVLNDGVYDFGSAFLSQLHKIKPSALEVGAILVSDEHDDQVNAVIREAAARDTGIKWALNNGKWVFGIKSEAGVIREAQKYTLKHVVEQINTPTLVLDAPDDHFLKGQPQELFGRMTCEKALISLTRDEGASIHCHAGAGSRLAQVVMDWLLERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUL1</accession>
    <name>A0A7D5UUL1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ptc1</name>
        <name evidence="8" type="ORF">G6M90_00g041750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUL1"/>
    <dbReference type="GeneID" id="26240081"/>
    <dbReference type="KEGG" id="mbrn:26240081"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="141"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="589" mass="62453" checksum="266D82ABEC5E20F4" modified="2021-02-10" version="1">MFGGGSNSPGLKTESESKAETKPPSPGSSPKANPPAPIKTAITSPASGEKRSGNGSPRYNDTGGSTDKKRRSSGVGSKASSFLASAKNTLNFSQVGRGNSDLSAQTPLQKLGKQDPALAVPQGQHNNSAGESLPGPKSTFRVGVWEDRNKKCRRTMEDTHAFLYNFLATPQPNSDAPSKAKSEKNDSEGTGNEMLESDNGYFAIFDGHAGTFAADWCGKKLHLILEDVIRKNPNVAVPELLDQTFTTVDTQLEKLPLKNSGCTAAIAVLRWEDRVSNEKPAAGATKQTPKTNEANNPDKDKPSSSPRGRTASASSTDTQLKPKLPTTRQRILYTANVGDARIILCRGGKALRLSYDHKGSDENEGKRIANAGGLILNNRVNGVLAVTRALGDAYMKELVTSHPYTTETVIQSDTDEFIIIACDGLWDVCSDQEAVDLVRDVQDPIAASKQLVDHALSRFSTDNLSCMIVRFDKTSTVAQGVSTSESEGGSDRIAAARVSEAEKIVSDTKQAIAEGTVPAVGVSASNSGRGYDTIPREGGEFIVTTLSEPVAEETESAVAEDDSPEVSTKGKDAPEAAEAATKPDEGPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUW0</accession>
    <name>A0A7D5UUW0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LRRC40</name>
        <name evidence="4" type="ORF">G6M90_00g040520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691914.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26239963"/>
    <dbReference type="KEGG" id="mbrn:26239963"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF27">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="902"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
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            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
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            <end position="129"/>
        </location>
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            <end position="162"/>
        </location>
    </feature>
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            <begin position="256"/>
            <end position="272"/>
        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67536.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1142" mass="122892" checksum="6B7C8846E3F8C9D9" modified="2021-02-10" version="1">MDGPRDRPSGIPRLSRLPVPRSSVPKTAPLASASTSTTTPVRPKASRDSLGGGELNPPKLRPVASRDQLRNSVGVVGNRGSPLRSVSSRDQLRSSTLQPIKTKPQLNQTQRKPRSPSSQQRASSTTPQPLAIDVSSNAANEDEWDHSPTQNPHASSPSTLSGNAAELGGEAIFQGDSLDCDQTAFHTFQTPSTRRSKPGPSLAERTMETLAQIPPSPALSKTSSSFFDQGRPRSRADGGNSRPGSSYNSDGFGRASSRQGSRPGSSAGQDDSSALFRASVNPFKTTLSAISGTPRRTSAISVANTPQTRAASNRALLVSTTKLGNTGISYIQDAVRSTSPEKKMFEKGSIRSGSKSVASRSTKPRASTAGLFKKPSLPSMPKAAGAPSESWDGAILPSSSVSGPTDSAPLTNRKSSAALREQIAKAKAAKRAAVRQASENHGSNGLHTTSSTVTNGFDLEHDDPFNLSKGEKPSVKVLQQRVTSARTTGRLNIAALGLKEIPEEVMKMYDLESISSYGGTWAESVDLTRLVAADNDIERLDDNIFPDTSPEAFDEQEEGQGSIFGGLETLDMHGNLLADVPVGFRRLANLTSLNLSSNKLENSSLDIISQIGSLRDLKLSKNQLSGPLNSALMKLGSLEMLDVHGNSISALPPDIENMQHLRILNMNENRLESLPFDSLSKLPLTELSVRKNKLSGVLIQQPVESLPCLQTLDASANQLTHLIPVDTVISLPVIHAISLSVNRLQCLPDMSTWTNLLTLAVDENHIANIPDSFIGLQKLRHADFASNDVRIVPPEIARMQSLSMIRLTGNPLRDRKLISAATDELKEILAGRLEPPPPYQEPGHPTTITGLMGSLSEIDDRLKTVGDMDTFPPSNDGDVRSDVEDDFTTPPTSAPHTPNRSRSQTVVKDVWFVKSGGLLDLSRSDMSSLNPNTCSTVASQNQVRQIQLHHNPIASIPIALGAFGSTLSFLSLAYAQIAGDSYLTETLDLPALRELSLLSNQITSLNPVTKFLKAPSLEKMDVTLNRVTSLPTSLKQAFPQLSVLLMASNQLSELDPEWIRGLKIVDASSNNIGQLTPRLGLLGGVDGLQRLEVAGNRFRVPRWTILERGTEATLRWLRERLPTEEMAAWRAANGEDSGEDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV86</accession>
    <name>A0A7D5UV86_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SKN7</name>
        <name evidence="11" type="ORF">G6M90_00g043260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV86"/>
    <dbReference type="GeneID" id="26240224"/>
    <dbReference type="KEGG" id="mbrn:26240224"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF361">
        <property type="entry name" value="TRANSCRIPTION FACTOR SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="351"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="566" mass="62314" checksum="207C15770D9F2EF1" modified="2021-02-10" version="1">MSGSEVPAATGGSNNASEFVRKLFRMLEDPSHQDVARWGKDGDSFVVVEGEKFTRSILPKHFKHSNMSSFIRQLNKYDFHKVKPSSDSESSNPGGNVLEFKHPYFRADSKDGLDNIRRKAPAPRKPQVTEDFTTSQHVSVVTEQLTATQQQVQQLQELYAEVSQANRLLVSEVMTLQKMVNAQKQAQYEMLNYLSPYDERSRGIMGQSMNSNGSNDVEDGVPELRRARELLSSVAPDTVSDRELERLHDIYAAPTESATLITPVTMPLMHDPMTDLSRYPVYPVGQTVGIDPFQPDHIHKIPFAIPNEGTPSTTLSSETTISAPAPISSVPATTGLGTDRATPMWGPKKPQVLLVEDDQTCAKIGIKFLNSMGCEVEHALNGVDAVTRVSNVGRDHFDLMFMDIIMPRLDGVSATMYIRQHCPTTPIIAMTSNIRPDEVNGYFEHGMNGVLAKPFTKEGMLKSVRTHLAHLLKDPPEQSEAGFMMSNVSYVGAAPPSLKFESSTPPGGNSSGWSPSHMGPSNADQWNGMMNGGNQYSVGRSSFTATDHDSPPEKRQRLNVSQANYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVC7</accession>
    <name>A0A7D5UVC7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)/H(+) antiporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SOD22</name>
        <name evidence="8" type="ORF">G6M90_00g034300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546828.1">
        <property type="nucleotide sequence ID" value="XM_014691342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVC7"/>
    <dbReference type="GeneID" id="26239391"/>
    <dbReference type="KEGG" id="mbrn:26239391"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF1">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="39"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="620" mass="68197" checksum="1D2EA40808AA0C6F" modified="2021-02-10" version="1">MANYTLQENKGIWAVPLEITDFNILVALLGGFISVFGLVSYLFKETFCLSEALISLLVGVAFGPYAADWIRPWSYAACHRDGLTDAQCQDRLNAITLNFSRLVLGVQLVLAGVQLPSKYLWKELKPILLLVGPGMACMWMATSLLVWGLVGTPSFLHALAVGACVTPTDPVLSAVIVKGKFADHNIPKELQDLIVAESGTNDGLGYPFLFFALYLIKYIGSGATEGGAKDAMGLWFAITWGYTIILSIIYGAVVGWIGKELLYFAKKRNYVDHESFLVFAVALALFVLGTCGLIGTDDVLACFIAGNAFTWDDWFRLQTKDDSLQPTIDMLLNVTIFLWYGAYLPWNDFAHNSIIPLSRLIPLGLLVLLIRRLPWIFGMHKAIHQISQVRQAIFVGFFGPIGVSAVFYLYIGIEFIQQHLSDENSVPRSDVKDLAETITVVVWFLVVCSIVVHGLSIPLGKLGYLAPRLHRVLSESLSETISTDRFSVQARRRIPFFGRFVREPEDVEANLAAQVRQGTAPIRRTGQGVVPSKIKQPEQDSRGAPAAGQSSHEDAESSGTRIDVEAEARVSGEWTPAKGRNQSSDEPEARKSEASTPGRSARREIQFSDEVPQSPPAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVD6</accession>
    <name>A0A7D5UVD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mep</name>
        <name evidence="15" type="ORF">G6M90_00g035760</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546971.1">
        <property type="nucleotide sequence ID" value="XM_014691485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVD6"/>
    <dbReference type="GeneID" id="26239534"/>
    <dbReference type="KEGG" id="mbrn:26239534"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029032885" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="84"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="641" mass="70076" checksum="5A81622ED74A27A0" modified="2021-02-10" version="1">MKSAAILGLTGLAANVLAHPQRHHANEASLGKRGVDVSQFRMPGSSEYTVSTQAESDPAISSIQKRGDYVSSATQLVKTVLPDAEFRVVDDHYVDTDGLAHVNFKQTVHGIDIDNADFNVNVNPDSTIFSYGNSFYNGEIPPESPIQKRGFTDPVNALKAVVDILALPVNPTDATSEAMEGAETYTFKGTSGAVSDPAAKLVYLTKDDGSLALAWRVETDVMDNWLLTYIDADNSKDVHGVVDFVSEFATLQVYPWTINDPTEGARSVQTDPWNVDASPFTWFGDGSQDYTTLWGNNAVAQTNRDGHNNTNDFANSYRPTSADRKFEYNYSPTQSNSTEYQDASITQLFYTANTYHDLLYTLGFNEAAGNFQTNNNGKGGKGNDFVVLNSQDGSGTNNANFATPPDGSRARMRMYMWTLASPQRDCAFDSDVVLHEYTHGLSTRLTGGPANSGCLNGLESGGMGEGWSDFMAVAVLAKANDTRTKDFPLGVWVSNKPKGIRSFPYSTNIQTNPYTYASANEKNEVHAMGEIWANTLYEVFWNLVDEHGITADKYPTFDDKRVPKDGRFLTMKLVMGGMAIQPCNPSMVSARDAILDADKKLTGSANKCLLWKAFAKRGLGENARYNGGRNRTEDFTVPAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVF1</accession>
    <name>A0A7D5UVF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-arabinitol dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARD1</name>
        <name evidence="7" type="ORF">G6M90_00g050050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986483.1">
        <property type="nucleotide sequence ID" value="XM_066130479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVF1"/>
    <dbReference type="GeneID" id="26242453"/>
    <dbReference type="KEGG" id="mbrn:26242453"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="170"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37397" checksum="531339B3388D6228" modified="2021-02-10" version="1">MANLPKEMKALRYEKPEDWSIVTVPLPELRDSDVLVQVKACGHIHEGEFIAKFPLIPGHETVGVIAALGKNVKGFQIGDRVAADNSELCNECFYCRRGQLLLCENFNAHGVTMNGGFAEYCAYPAAKVFKIQNLNWVDATLLEPASCACHGLEKIRPKLGSHVLMFGAGPTGLMLAQLLRQNGGCQVTIAAPKGLKMDLAKSLDAADTYIELSRESPQAQFDQLKKDNPYGFDIVVEATGSVKILEDAIHYVRRGGTLVVYGVYANADRVSWPPAKIFGDEITIIGSFSETYMFPATIDYLDSGKVKTKGIVNKTFKLEDFDKALQSIKDKTAIKAAIVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVV1</accession>
    <name>A0A7D5UVV1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein mrp51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g046560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544782.1">
        <property type="nucleotide sequence ID" value="XM_014689296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVV1"/>
    <dbReference type="GeneID" id="26242123"/>
    <dbReference type="KEGG" id="mbrn:26242123"/>
    <dbReference type="OrthoDB" id="3913595at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51259" checksum="2EE0BCF8672BD2FA" modified="2021-02-10" version="1">MGARAVSPGGALLRTSRMFSVPKPLPEPPSTSLHIGDHKSATMTRQYPQHQSITTPLSSREKGDWGYKRPFPLKSTMTTSTPLIRVKKVDSVENVTDFASAADHSLSLEKFQELHVAMSVPRGKIPGEARSASLWPKSVFEEELDSTESQSGRSDDKRWKFRGPWLARMGEGEFVRYLRKTVHPKRAQFRALLKRKLAEDITTSQNKLALEKGTPAPPKVEPRDITEAHFSEYLRTLRNDRTTLYSLVSEFLDLAPLAVPIGLFQSFQHMNPPLESGSLYGNSGPPPSHPSAGISYLRTNSYMENHPVYGPQGRRTPVLARVVYPRAGHKPAKLGVGGFVADVPIGDNEFNIRYGRGRTQANKMLNGIAHLDTTTYGGAKAYIEPKTATVDPSGKVVLQLRETHPEAQVIAKESKGQSHIYHDAETKAKQATQFQGDKSTGRRIERITDEILNDDSSKVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW94</accession>
    <name>A0A7D5UW94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g030260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986588.1">
        <property type="nucleotide sequence ID" value="XM_066130055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW94"/>
    <dbReference type="GeneID" id="90967572"/>
    <dbReference type="KEGG" id="mbrn:90967572"/>
    <dbReference type="OrthoDB" id="4174307at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="214" mass="24029" checksum="9F6E89EED81F75C5" modified="2021-02-10" version="1">MSRSIKVSGAAKNCYFLSYTPDVHAHLPFFPVTLSMDSQTGDRISFNLSEDRNALPQSLLQTVCSKLYVELLKTTTPEQGQHGEEGIAEKKQAANHAVFKIIFADKCGTYEGMRLEVICLMRRGGFIQSTDISEVLAGPDLSVRSIYEALGFRLDYRGRIWASPIDKGRFPWRHYQSPLMPYHGSQKALELAELWAPSSLHVPHSQNLDKDIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX48</accession>
    <name>A0A7D5UX48_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump FUS6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FUS6_0</name>
        <name evidence="8" type="ORF">G6M90_00g045900</name>
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    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986593.1">
        <property type="nucleotide sequence ID" value="XM_066130404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX48"/>
    <dbReference type="GeneID" id="26242058"/>
    <dbReference type="KEGG" id="mbrn:26242058"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
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        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="545" mass="58231" checksum="9DA030AA0F1FDF1F" modified="2021-02-10" version="1">MSQHGRHEGRASAHSFTSTVQTESTKPPPIPLARFWILCVGVCLGLFLSMVDTSIVATCLYAVGTEFRDLNSVNWVALSYTLAYMGFSVVFSRISDITGRRDAFVVAYVVFVAFSLACGFARTLHQLIAFRALQGIGGSGLYSLSMVMLSELSPVHLRQYIAAMIGLVVAMSGVLGPVLGGLLASYTSWRWVFWINGPIGAASLATFVFSWPNRRHLPHHERHSWKQLDWPGAFLTVAAAVLVVFSFQNAGQTPGTASHGNSWGSAVFIAPLVVGVVCWGALMLWEYGVEYRLSRRFIPVLPLGIFRSVVYTSGVINTLLLGLPYLLLIYIVPLRIQIVGGKSALLAGVMLLPMLVAVALGSVVSGAVNSKTPVITETLLAGSCLMVLGCGLLTTLSTQELDGAKLLGFIALCGMGFGLTVSSSTMIASIKVAPKHYAPAQGILAQLRIFGGSLGIAASTAILRTKTQGGLLPVGKRESQAPGSQSQSVKMAFAEAFRTDMMVATAVSGAAVILALVAYWLRRNNQSEPEGPRTSPERRTGDENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXB5</accession>
    <name>A0A7D5UXB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g048160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXB5"/>
    <dbReference type="GeneID" id="26242272"/>
    <dbReference type="KEGG" id="mbrn:26242272"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="203"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31609" checksum="706035E2E9E6427D" modified="2021-02-10" version="1">MSRYGWSLSREQSSPYSSMAGGVPAVRDEDFSYITSQDLEDHSYLGTRPGGPPPEDDVLLIKNKGVTYPAHFPAYSIGDGKLRVKDVRERVGLMMELSQSATRRIKLLYKGRQLKEPAAPVRDYEVKNNSELLAVLSDIQDESSPSEEEMVIVNDNQSGRRKKKRSKKKGAKAGGDSASSPRDSTSNVEASSPTPGAGPMKKLDELSDEFTKNWLPLCDNFIASPPSDPKKREDEHRKYSESLLQIILLKLDAVDTEGIAEVRARRKALVKKVQDTLKALDAAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXQ2</accession>
    <name>A0A7D5UXQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein rsm22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g061830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542689.1">
        <property type="nucleotide sequence ID" value="XM_014687203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXQ2"/>
    <dbReference type="GeneID" id="26244638"/>
    <dbReference type="KEGG" id="mbrn:26244638"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34389" checksum="4098E3332B714783" modified="2021-02-10" version="1">MTLEVWPHISPEELQIKAAESLDRELEWIVQETMTLCHELKHGIEDCYALLAPIEPGSTLVMSTHRNEKVKGTITRVGTRLVKGTLSLQLRTLPPQQLTISALEPIHIPPLDAIFTNLTQSIDLLGLLLDSKPAPTADNIASALAALAECLAESAGLLKGSTSSEPDPAWQTASCPAHHFSPAMPPNLSFFTTLQESSIVLWLRALEPADAPVHFGVKLGLAIGTVRRLEHDEMDTVFRYDPDGDGSCEPKRGLGGSRTSGKRDREENVFVREKVRIESADPSLISLYSKLGFLSHMLGQARYNLAAVMGVELDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXY3</accession>
    <name>A0A7D5UXY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation initiation factor 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g065280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540246.1">
        <property type="nucleotide sequence ID" value="XM_014684760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXY3"/>
    <dbReference type="GeneID" id="26247055"/>
    <dbReference type="KEGG" id="mbrn:26247055"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 3 C-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="280" mass="31093" checksum="64903500503A8AAF" modified="2021-02-10" version="1">MRPMPQCVYNSRRALYRVFVSPSEAPALSIVSRLQLSPLPAPHRNALAASQVRRYAAKPPARGPRGQTSVAAAEQLAHDNRGFDKRYTTQQDIARSGRDRPPQDHEITDPQIMVIDNGATEGPLATPFVLTRLEPHESLRMVQPYVPADPKNGRPGAQWAVCKIVNKRDEYERQKQLKEKKKAGVGKPKTKELELTWAIGEHDLATKMRQMGQFLDKGMKVEVLVARKKGGKQVDGKEAEGVVRRIRDEVDKVGGREGKSASGAVGGTYRLYLEGKQNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXY5</accession>
    <name>A0A7D5UXY5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 22">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">MIC60</name>
        <name evidence="25" type="ORF">G6M90_00g059730</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 22">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Mitochondrion inner membrane</location>
            <topology evidence="2 22">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544543.2">
        <property type="nucleotide sequence ID" value="XM_014689057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXY5"/>
    <dbReference type="GeneID" id="26242955"/>
    <dbReference type="KEGG" id="mbrn:26242955"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 22" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="188"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="350"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="572"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QLI69558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="831" mass="91762" checksum="4FF6F4AFCBE0575F" modified="2021-02-10" version="1">MSSRGPTAGARGANNRFAQFKLVLLGESAVGKSSIVLRFVKDQFDSFRESTIGAAFLTQTISLDENTTVKFEIWDTAGQERYKSLAPMYYRNANCAVIVYDITQSSSLDKAKAWVKELQRQAKEDIIIALAGNKLDLVTEQPDKRAIPTADAEAYAREAGLLFFETSAKTAENVRELFTAIAKKLPLDQAGPRHTRPGQRPGVSLTPENANTNRSYADTKKPDADVPKPPVMPTSETLSSERSPPPPAAEVVDANTPKTSNVPLTPPPPPPPTEATKALAKKKKSFSQRLRSFVFTLMVLGAVGFAGGVWYSRINDNFHDFFTEYIPYGEQAVLYLEELEFKKKFPDAVSHDSQSRETGKQVKIPAQSGASWRVAESSDASSRHSSASPATVKPVIKQAEKKDIADKTPSDPVTAQSKPAEKATPKAVGEHPTTDSSKPSSKKEFKAPEVNEPSRFPPLEPIDLMGLSEAKDPIVRDLVHMLNDLILVVNADGAHGRYSTTIAKAKNEVLRIGSRLRDLKKGIEKKAAGEVKSSIEEFDTAATELIKRVENTMLSQEIEWRREFEEEMKSVRNSYDERVQLLMEREKKLNEEKLQNQLLEQALALKKEFVQEVKDRVEKEREGRLGKLADLSSAVSELEKLTVGWNGVVDTNLKTQQLHVAVEAVRASLENATHPKPFIRELVALKEIADDDAVVDAAIASLNPLAYQRGVSTPSLLIDRFRRVAAEVRKASLLPDDAGVASHASSWVLSHVMFKKEGLAEGNDVESTLTRTQTYLEEGDLDSAAREMNSLQGWAKTLSKDWLGEVRKVLEVQQALDVIATEARLQSLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYZ0</accession>
    <name>A0A7D5UYZ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Synembryn-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g057550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544336.1">
        <property type="nucleotide sequence ID" value="XM_014688850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYZ0"/>
    <dbReference type="GeneID" id="26242748"/>
    <dbReference type="KEGG" id="mbrn:26242748"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52562" checksum="C23A93F8DA8DC96A" modified="2021-02-10" version="1">MATIAKGAATGPAKLQAVADLVNRLCDDLENISLLPKDRNDALEELKIYGRDPKYADPIFTKDGFTMLLRYSFQNPPDDTSRAALRVVANAMLLKPETRQMFVDQGYPAQACDRLRGGNWDDEFLLSRALFLSTYGTNIDLPELIDSHELAQHLINNLRRHVKILSDKQKEKLDPMEDMALGETLKLMFNVTHFSKTHVSSFAPAVPLIVALILKHEIPEPKPLDPPFGPLINSLLNLDLRIELSRLALYPENEPHKLTSRLVDLLDQGIRAYSGNDLETVVTPVVSLLARLYENAPQPVQQKLRECLLPTAEDRQGVLGRSDSLPSHLLKNSTNPTAPALRDAISHLLFDISDKDASKFVENVGYGFASGFLFQNNVPVPASSAATFRKGDGFGAQKLVNPITGQFLDREKIADAPEMTDEEKEREAERLFVLFERLKKTGVVNIQNPVEKAVQEGRFEELSDDCVEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZC4</accession>
    <name>A0A7D5UZC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rec12</name>
        <name evidence="14" type="ORF">G6M90_00g063230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542560.1">
        <property type="nucleotide sequence ID" value="XM_014687074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZC4"/>
    <dbReference type="GeneID" id="26244509"/>
    <dbReference type="KEGG" id="mbrn:26244509"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="79"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="189"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="43477" checksum="04BFC11FAEA11A82" modified="2021-02-10" version="1">MTSNGHQASHVGSIPTEHLNYAGAAISRIESIFESAINNLLHNEPMSIALASRRSLRRRQSHVALRQIQFPGRSAQEAQRFARVLLILQLSHDALVSGTVLTKRNIFYQHQELFGTQRVVDELVDDVATTLELDRDDLNIVASAKGIMAGPLRIRLIDGGELDASSSDTGVVIPTSRSIQSIDVGSLRWVLVIEKDATFRSLASTLYWETSTSGNGLLVTAKGYPDMITRSFLHLLGRQQPDIPIFVLTDFDPDGLKIFHCYLHGSGNILTDSTVDNPSFSWLGIRSSHLAAMDRVLQTSNSGSSQPPPTSSSTPALTSFTAQSAAVALTLRDRKMIVDTLKAFETEDGVTIGSLRRELQYMQVLGYKAEIQLLDDSGNLDSWLDTQIQIEMNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZH8</accession>
    <name>A0A7D5UZH8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome biogenesis protein BRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BRX1_1</name>
        <name evidence="6" type="ORF">G6M90_00g064770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540067.1">
        <property type="nucleotide sequence ID" value="XM_014684581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZH8"/>
    <dbReference type="GeneID" id="26247103"/>
    <dbReference type="KEGG" id="mbrn:26247103"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000009">
        <property type="entry name" value="Ribosome biogenesis protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="5">
        <location>
            <begin position="31"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="28955" checksum="0466C9E178B9B371" modified="2021-02-10" version="1">MVSVYKRLSTVTRIKSGAEDGSPKAKPMNAQRVLLLSSRGINARHRHLINDLAALLPHSRRESKFDSKKNLHDLNELADLYNCNNLLFLEARKQQDLYMHISKAPNGPRARFHVQNLHTMSELNFMGNTLKGSRPILSFDTAFNGEPYLRLLHELLTHTFGVPPTARKAKPFIDRVLAFIVADDRIWVRHYQIAKEEDDATKDEKLSLREIGPRFCLKPIYIQEGSFGGPIIYENKQFVSPNQVRADLRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZQ1</accession>
    <name>A0A7D5UZQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-splicing factor prp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">prp1</name>
        <name evidence="10" type="ORF">G6M90_00g076850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545418.1">
        <property type="nucleotide sequence ID" value="XM_014689932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZQ1"/>
    <dbReference type="GeneID" id="26241451"/>
    <dbReference type="KEGG" id="mbrn:26241451"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000304">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="694"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="925" mass="104603" checksum="5D2C73759985DCB5" modified="2021-02-10" version="1">MASKLDFLNQKAPENYVAGLGRGATGFTTRSDLGPARDGPSEDQIKEALAKRAAQLGLAPDGKKKDDDDDDDERFQDPDNEVGLFSGGIYDKDDEEADRIWEWVDERMDRRKKQREAREQAEQEEYERKNPKIQQQFSDLKRALETVTDEEWSNLPEVGDLTGKNRRSKQALRQRFYAVPDSVLAAARDSTEMSTTVTDDGVASSATDKADGTMTNFAQIGAARDRVLKSRLEQASRTNGDASNGSSTSIDPQGYITSLNKMQMNEAQAQVGDINRVRELLQSVVKTNPNNALGWIAAARLEELAGKIVAARKTIDQGCEKCPKSEDAWLENIRLNHDSQNAKIIARRAIEANNRSVRLWVEAMRLENIPSNKKRVIRQALDHIPESEALWKEAVNLEENQDDAKLMLAKATELIPLSVDLWLALARLESPENAQKVLNRARKAVPTSYEIWIAAARLMEQLGQASKGNVMTTAVRVLAKESAMPKREEWIAEAEKCEDEGAILTCQNIIHATLGWGLDEDDDRKDTWMEDARSSINRGKYDTARAIYAYAIRIFYNSRTLRMAAADLERNHGTKESLWEVLEQAVDACPTSEDLWMMLAKEKWQAGEVDNARLVLKRAFNKNPNNEDIWLAAVKLESENDNAEQARKLLEIAREQAPTDRVWMKSVVFERVQGQVETALDLVLQALQLFPAAAKLWMLKGQIYEDLGKTAQAREAYAAGVKVVPKSVPLWLLYARLEEKSSMTIKARSVLDRARLAVPKSPQLWCESVRLERRAGNLSQAKSIMAKAQQEIPKSGLLWVEQIWHLEPRTQRKPRSLEAIKKVDNDPLLFVGVARIFWADRKLEKAQNWFEKALVLDSDSGDSWAWYYRFLCQHGTEEKRSEVASKCVLSEPRHGEVWERVAKEPRNARKGVEEILKLVAEELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZU1</accession>
    <name>A0A7D5UZU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g068170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540573.1">
        <property type="nucleotide sequence ID" value="XM_014685087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZU1"/>
    <dbReference type="GeneID" id="26246680"/>
    <dbReference type="KEGG" id="mbrn:26246680"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617:SF2">
        <property type="entry name" value="UPF0039 PROTEIN SLL0451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="174" mass="18988" checksum="80E7A1291AE5306B" modified="2021-02-10" version="1">MTDSNQICIRPERESDAQAIDLVVSVAFTNAEHSDHNEHHIVRGLREANCLSISLVAEDEATHAVVGHVAVSPVNISDGSEDWCGLGPIAVLPQYQGRGVGSLLMERALATLQARHSAGCVVLGNPKYYTRFGFRPEPSLRLQGVPPEYFMALTWRKPTPTGTVSYHHAFELSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V080</accession>
    <name>A0A7D5V080_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">THR1</name>
        <name evidence="18" type="ORF">G6M90_00g077560</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Commits homoserine to the threonine biosynthesis pathway by catalyzing its O-phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545346.1">
        <property type="nucleotide sequence ID" value="XM_014689860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V080"/>
    <dbReference type="GeneID" id="26241379"/>
    <dbReference type="KEGG" id="mbrn:26241379"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000068">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="265"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI70853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="38622" checksum="45F957322EC2CE8C" modified="2021-02-10" version="1">MESFVIKTPCSSANIGPGFDVIGLALTVYLELHVTIDRSKTSTEEPLNCRITYEGQGEGTEDISLDPQSNLITRVALYVLRCHDQRAFPVETHVHIKNPIPLGRGLGSSGAAVVAGVMLGKEAGGLKNLDLDRLFDYCLMIERHPDNVGAALFGGFVGTYLMPLNPEDAARIEIPLSEVLPSPAGGVDTGKKPPSPPVGIGHHIKFPWAKEIKAVAIIPDFIVPTASARAVLPEKYPRQDVTFNLQRIALLPVALGQSPPDPELIHLAMQDKIHQPYRQTLIPGLTEVVESMSPKTQPGFLGVCLSGAGPTILALATSNFEEIANKIIATLRQYNEKKDLACEWKILEPAEGTHVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0B7</accession>
    <name>A0A7D5V0B7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SF3B5</name>
        <name evidence="3" type="ORF">G6M90_00g090210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541679.1">
        <property type="nucleotide sequence ID" value="XM_014686193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0B7"/>
    <dbReference type="GeneID" id="26245542"/>
    <dbReference type="KEGG" id="mbrn:26245542"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9681" checksum="2152ABB231C99018" modified="2021-02-10" version="1">MADKLRTQQELERLQAKYIGTGHPDTTSWEWRTNIQRDTYASIAGHRPLLSYVALAENEPLVKVRARMIRKMIQPAGPPPPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0I8</accession>
    <name>A0A7D5V0I8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bah_1</name>
        <name evidence="6" type="ORF">G6M90_00g086480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987290.1">
        <property type="nucleotide sequence ID" value="XM_066131288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0I8"/>
    <dbReference type="GeneID" id="26244980"/>
    <dbReference type="KEGG" id="mbrn:26244980"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF2">
        <property type="entry name" value="ALPHA_BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="149"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="415" mass="46593" checksum="07F73FC8F221E74F" modified="2021-02-10" version="1">MILGPVSLLDCVVAGIIIAPQMLFTVGPLVTLTVVIRILPFLLFKLPFHFLARYVKPRYAQPWFIAESTVFEDMVIRIVRFGFMNLPVRAARVLFSKQFAYPFLKWRMFRSGHFSFPAHLQETVIEQGNTSAAGLWIKHDPEQEPDVVVYYIHGGGFALGSCYFYLEFLLSMHHLLLKSGFESPAIFALEYSLAPEETHPTQVNQAVLGYRHVLEDVKDASKVCIAGDSAGGTLTLSLLLELGKKTNEFQLNGATTLAVPKLAVLISPWITLVSNIHYPSEVDYLERDTLWKYGKAYRGSAVHDPIASPGLCEDGDLWTAVSPQRGYFIVYGEEETLAPDAEAFVRHQRKNKIEVDAMEFKGGIHAWPVASLMLSGTWDRRLQGLESIVGHVRQKFMNDIVTRKKNTISDIEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0T2</accession>
    <name>A0A7D5V0T2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ssh4_0</name>
        <name evidence="19" type="ORF">G6M90_00g084840</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541044.1">
        <property type="nucleotide sequence ID" value="XM_014685558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0T2"/>
    <dbReference type="GeneID" id="26246033"/>
    <dbReference type="KEGG" id="mbrn:26246033"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="81"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="315"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="405"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI71615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="500" mass="54089" checksum="ECB712509ED15FC4" modified="2021-02-10" version="1">MAVSSPPTSAFTGVIIGLVSSFGSIVLIALVVFVFWASGCAGSGRIILDRLGRPGEYDDEQAFLREEAEALETMDDMTRTEYLRAKAFVTANPPESLHTDISLSQYLAIQEKGVSAWEFEPELEVANCFVEARTEIEFFDSECTVMCNLPVPKQNDVYYWEAKIYEKPENTLLSIGMATKPYPLFRLPGYHKYSVAYHSDGSRHYNQPFSSTPYAPKLVQGDVVGVGYRPRTGAIFFTRNGKRYEEVVHGLKSQNFFPAIGANGPAIVHVNLGQSGFVFIEANVKKWGLAPVTGSLAPPPPYGSEQGSILLETGTKDGAFSGQGLPHRQSVTGSPYTVTGGRSNLNPSHGRTRSGNFRVLPPTSPGPVRSPTDISLAQLVPNDEGGEASGSTGHQEAYHDDNPLHLHLEDATNPPPDYSSPTHSDSGQDRRRYSTDSEENTPLIRVMNRGRGDSSATATPRLQNTPSGPVPSYSDAVRDGAGIQRSDSSESDSSDASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Z4</accession>
    <name>A0A7D5V0Z4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g078130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545294.1">
        <property type="nucleotide sequence ID" value="XM_014689808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Z4"/>
    <dbReference type="GeneID" id="26241327"/>
    <dbReference type="KEGG" id="mbrn:26241327"/>
    <dbReference type="OrthoDB" id="9992270at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40135:SF1">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9409" checksum="A97ACEBC2C852FE7" modified="2021-02-10" version="1">MIVTRAISLTNFLVASSALGFQVFVLYPWHKELDAGFEELKKEHLKVLNAVGSSLSEQQRRGFMDKLNDMKSQSAKRWWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V136</accession>
    <name>A0A7D5V136_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539335.1">
        <property type="nucleotide sequence ID" value="XM_014683849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V136"/>
    <dbReference type="GeneID" id="26247878"/>
    <dbReference type="KEGG" id="mbrn:26247878"/>
    <dbReference type="OrthoDB" id="4611802at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028946674" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="81" mass="8739" checksum="28A2A0C0FEFEF2E6" modified="2021-02-10" version="1">MKFIIASVAALASVAIAAPGSETPERCKPATYRCDPNVNGWDVCNTSNLWVFAGNCPPKTICKFFQENGSPYCVPPNFTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1D5</accession>
    <name>A0A7D5V1D5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear protein Qri2/Nse4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g091520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541800.1">
        <property type="nucleotide sequence ID" value="XM_014686314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1D5"/>
    <dbReference type="GeneID" id="26245268"/>
    <dbReference type="KEGG" id="mbrn:26245268"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30804" checksum="314B04C96462F83F" modified="2021-02-10" version="1">MSADLIPANPADLMVIRNVTPNIATFSVPFSRFGRIKIGGRGTLVKLTSGNLAVFSPVALTEETRAKVNEFGGNVGYIVALDFEHHIFISEWAKQWPNAKIIGPEGLPEKRAKQLKDPKINDDNFAVIFKKDGKRDVKISQEFDADFDYEYVDGHANKEIVFNYKPDKVLIEADLLFNLPATEQYSKVPESQRPGGFLDKLFRGVQNTEGDATWAKRFNWYLAKDRNSMNESLKVIAQWDFTTLIPCHGDVIEGNAKEVFDKIFEWNLRGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1D6</accession>
    <name>A0A7D5V1D6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CPK4</name>
        <name evidence="13" type="ORF">G6M90_00g087110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542407.1">
        <property type="nucleotide sequence ID" value="XM_014686921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1D6"/>
    <dbReference type="GeneID" id="26244921"/>
    <dbReference type="KEGG" id="mbrn:26244921"/>
    <dbReference type="OrthoDB" id="4937735at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="270" mass="30091" checksum="52F8B54D76809CB4" modified="2021-02-10" version="1">MKTLVGTANYQAPELYDSQSAQTPAIDIWSLGIVAIIMLTAGLGIENTMPKFNRYTQTVLNRTLKQDIFQPSLKLSKNSKTFVWQCLQISPKARISGLEAICHDWLCTPEKHLLFFQQLDHKILGSWKAPVKLNPLPLQLPSVLMGALAQARGQEELFKAYSDLSRHYPLLQTEFSKYFGKATLKNNLKEVVGERKLSTKAEFGQPRESQATAASSDVPGSSGTGSALFSRETTDTHKKSIFVISPKRKNDEALHRDMKRQTVPGRKTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1K5</accession>
    <name>A0A7D5V1K5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546019.1">
        <property type="nucleotide sequence ID" value="XM_014690533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1K5"/>
    <dbReference type="GeneID" id="26240442"/>
    <dbReference type="KEGG" id="mbrn:26240442"/>
    <dbReference type="OrthoDB" id="3519533at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="172" mass="18575" checksum="29EA3BF35094E535" modified="2021-02-10" version="1">MESLQLSQVLADLSNLGAAEPEAAAAIVNANVPIVKAEQLAEPKTSAPSPQPPRPTNMKRSWSSEAGVPPKFDKLGRRILINSGSRSGSAANSSPGTPRLSESIVDDDLERASTLMALYDIRAKIKQQDNSSLMRAREKINALAAKQQAADRSMKASDELRRHRYSFPKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1Q3</accession>
    <name>A0A7D5V1Q3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase/desaturase asaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asaB_1</name>
        <name evidence="2" type="ORF">G6M90_00g082510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543480.1">
        <property type="nucleotide sequence ID" value="XM_014687994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1Q3"/>
    <dbReference type="GeneID" id="26243657"/>
    <dbReference type="KEGG" id="mbrn:26243657"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="271" mass="31146" checksum="76B652316B81391C" modified="2021-02-10" version="1">MSNKHNVATTLNYWDDPGDGSKPTPIFIGKGRISNKRPHKAWDFVVTDISGDEDQYTLDGHGFQYCRHQSREEAFTDEQQIRSSYYAECEQLVKATTGARLVHIFNHKVRRGPTQWHHLGLHNLANRGPVTRTHVDQSYHGAERRLRWEFPAEADEMLTRRYQIINVWRPIQPILKDPIAVADAASVPDADLVGAEMTEDDFVGESWVVRHNPGHRWFYKHGMTPEDVLLIKCFDSDTAVARRALHSAFEDAAYRACESRQSIEVRCLVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V283</accession>
    <name>A0A7D5V283_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g091750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987416.1">
        <property type="nucleotide sequence ID" value="XM_066131405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V283"/>
    <dbReference type="GeneID" id="90968118"/>
    <dbReference type="KEGG" id="mbrn:90968118"/>
    <dbReference type="OrthoDB" id="10362960at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029020989" evidence="2">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16634" checksum="8C045E502BB881A5" modified="2021-02-10" version="1">MLVAFGPALILSFLVSFTQAFGNPFEYGTRPEPGHLSGVGPRDSPPDYGPPSYGYGYPPPYQYETSISTATWIISSGSSTFLTSVTTISTEALTVTNQPPSTSDKYTTLTYASTVTRIRLLGEKLGVGGDRGFDFFQFHRTGAFVFYRRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V292</accession>
    <name>A0A7D5V292_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein 78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hsp78</name>
        <name evidence="10" type="ORF">G6M90_00g100170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546332.2">
        <property type="nucleotide sequence ID" value="XM_014690846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V292"/>
    <dbReference type="GeneID" id="26240755"/>
    <dbReference type="KEGG" id="mbrn:26240755"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="447"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="625"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="260"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="724" mass="80716" checksum="1D6FF31184094114" modified="2021-02-10" version="1">MGGEEEKPALEQFGIDLTARAKDGKLDPVIGRDAEIQRTIQILSRRTKNNPVLIGNAGTGKTAILEGLALRIIRGDVPESIKNKRVITLDLGSLIAGAKFRGDFEERLKKVLDEVQKAEGQVILFIDELHTLLGLGKAEGSIDASNLLKPALARGELQCCGATTLNEYRQIEKDVALARRFQPIIVSEPSVEDTISILRGIKDKYEVHHGVRITDGALVAAATLSNRYVTDRFLPDKAIDLMDEAASHLKLQHESKPEDIMRLDHKIMTIQIELESLRKEKDVASQERREKLEKDLKEYQDEIAQLNARWEKERSEIESVKVIQEDLDKARFDLEQAQREGNFARASELRFGVIPTLEQKLPSDEESQQSQSEDALIHDSVTSDDIANVVSRITGIPVSKLTSGHIEKLVHMEDTLREAVKGQDDAIKAVSDAVRLQRAGLSGENKPLASFFFLGPTGVGKTELCKKLAGFLFSTESAVVRFDMSEFQEKHTISRLIGAPSGYVGYEDAGQLTEAVRRKPYAVLLFDEFEKAHRDISALLLQVLDEGYLTDAQGHKVDFKNTIIVLTSNLGADILVGQNQLHPYKESPDGEMDPSVRKAVMDVVAQAYPPEFLNRIDSFIIFKRLAQSAIRDIVDIRLKELQQRLDDKRIKLTVPDTVKDWLAERGYEPKFGARPLNRLITNEIGNGLADKIIRGQLKMGQAAEVKIKQDGMGLEVVNTFEIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2R0</accession>
    <name>A0A7D5V2R0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine deaminase TAD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TAD2</name>
        <name evidence="4" type="ORF">G6M90_00g083360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543557.1">
        <property type="nucleotide sequence ID" value="XM_014688071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2R0"/>
    <dbReference type="GeneID" id="26243734"/>
    <dbReference type="KEGG" id="mbrn:26243734"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="146"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="469" mass="50350" checksum="1B809CE03D55C579" modified="2021-02-10" version="1">MPLLQSLGLAPATNAVRKLFGWLGPKKENEKDGLRVPPSSDTESSLAHHSPQTSPTDTDTNASRRPQPPQVTIPHTSNPDIMVVADPWLSQEDKENRPPGKDDGSDLVGPFKKVAIDSHAPASADAADTKDVEEAIEDPAVLAERAHHLRFIEEALDMARLALRTNETPVGCVLVHNGTIIAKGMNATNVTRNGTRHAEFMAISALLSEPRRNGPRQTSLRPKDLPRRLPKTPDDASDASSVESRRPDEGNEDGKKGHLYPYGQKIHPGDRVSREIIRECILYVTVEPCVMCASLLRQLGIKKVYFGAVNDKFGGTGGVFSIHANSLPVREDGQTASAHPTPRPSQLPDGSGTLGTSYPPGGGDGGNVEEGYEIEGGWGRDEAVGLLRRFYVQENGRAPVPRKKEGRAARLAAMMEKDDEAGVDGPTVDGGQEQDAGLQQEDAVDASHDPNMAANGSPETQVDSAWVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V332</accession>
    <name>A0A7D5V332_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short-chain dehydrogenase TIC 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIC32_1</name>
        <name evidence="3" type="ORF">G6M90_00g105100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541499.1">
        <property type="nucleotide sequence ID" value="XM_014686013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V332"/>
    <dbReference type="GeneID" id="26245749"/>
    <dbReference type="KEGG" id="mbrn:26245749"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="37308" checksum="E75D25266AA59413" modified="2021-02-10" version="1">MAGKGTIIVTGANGGLGSAIAEHIASRPELLGHHGIYIVRDASAAPALAAALSRGSPSHKQEVASLDLTNLANVRQVAQHINSRVSAGQIPPIRALILNAGLLDFGKQTWTSDGFDVTFAANYLGHWLLTLLLLQSMDKEAGTIIVIGSQMHDPSDKRNDRSKAFEGKYKQIIGSDEASVEAVAKGTWGSAKEDPSFRSGLRRYGASKLCLLMMMFELQRRADADARLGNLRVVGVDPGTMVTSITRLAPWAMRVILFGAVLPAVALLFPRGPVRTPQRSGADVLHVAGLLGGANADARPGAKAVYYNGREPMETNPEARDAQKRALVWAESVKYTRLVGGETILGDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V369</accession>
    <name>A0A7D5V369_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein sfk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sfk1</name>
        <name evidence="7" type="ORF">G6M90_00g095910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546740.2">
        <property type="nucleotide sequence ID" value="XM_014691254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V369"/>
    <dbReference type="GeneID" id="26241163"/>
    <dbReference type="KEGG" id="mbrn:26241163"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="267" mass="30381" checksum="CE7D1DDA94E74E63" modified="2021-02-10" version="1">MAARGLFSYWLLPVFSSLVWLGMLLGMLLHWIVDTNRRIYPSMERGGSIAYISDIGAQKLKPLFIAGSAVTVVLLDLAFLAERWLRHRGRLVRNQSSGERALVWLSILFAFVGAAGLVLLSVFDTWRHKKLHDVFLLLFIGGYWLSAVFICWEYQRLGIKNRQYRILRSSFWIKLAFILVELVLAIVFVSTTFTHNNNVAAVFEWVIAFIFTFYVASFIIDLKPAIYTKSHAARFEKTHQMEDGLDVNGPNGLTGNGFVADRTAAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Y1</accession>
    <name>A0A7D5V3Y1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g095430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987741.1">
        <property type="nucleotide sequence ID" value="XM_066131496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Y1"/>
    <dbReference type="GeneID" id="26241210"/>
    <dbReference type="KEGG" id="mbrn:26241210"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="151"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="713" mass="80045" checksum="98F84B10BBC990D3" modified="2021-02-10" version="1">MSLIPYHPREGREIVLRHRNAVVVRDPESQRLEIRGSECPTCHQPLGRASSPERSFERPYEMNHEYVDPEYFRMLRAGNHFPRGNGPPSPVRRLVQPALTTRSATRSSSPQEPIPRQDESQFLSSSPGVPKAEGGRIRKEAFSPNYFRSFFVEERVLGKGGKGVVLLVRHEIDGCPLGHFACKRVPVGDDHSWLEKVLVEVELLAKLSHPNLVSYRHVWLEDVQLTRFGPSVACAFILQQYCNGGDLHQHVVGSAPRELTKEELKAQMRRRSKGQAEAPSGPARPQLSFEEIYSLFKDITSGVAYLHSANYIHRDLKPSNCLLHREGGKLTCLISDFGEVQPENAVRKSTGSTGTISYCAPEVLRIDVAGQYGNFTTKSDVFSLGMILYFMCFGRLPYQGANAIQEELEDIDQLRAEITDWQGFQDERQERPDLPSKLYKLLKKLLALDPTERPSANEVLLAMRSETNFDNITKGDWVASRVQNLDSPVPPGTPVPDPEKEKPRGRTGSRKGSVDPGPPHLNSFEAMENPTQTSPPNAFVNHDPHNHHHLELNQDEGRRGSDIVNGTRLLDADSSELPASRLLMAPPRTRAAEFIYQISILSHHMSSGLGLTTDTFDSIFRLAIFSLKVVTLTRPCWPYVVSFEVGTPLILIAAIELGWPTSAANNNWDERIIQRRLSITTSVALLGVHLITLWVARRWDILCTPPLQEEWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V407</accession>
    <name>A0A7D5V407_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g111210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987860.1">
        <property type="nucleotide sequence ID" value="XM_066131824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V407"/>
    <dbReference type="GeneID" id="26243128"/>
    <dbReference type="KEGG" id="mbrn:26243128"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="45651" checksum="FEF8DB2CF1969F7C" modified="2021-02-10" version="1">MSSSRFSQILWKAAPRLTCKEQVRQISLHEYQSQNILRQYGVPVPRGRTVKTASEARIAAQELGPACIIKAQVLGRGRAAGKFDNGLKSGIQAVSTPDQAEHVASKMLDQRLLTKDNGTDGHVVEKLYVAEAATYDSQWYLAMTIDRENYQPAIIVSKEGGVELDVLISERPDSLFTFGFGISEGITNALVQDIQQRLGTTDQETANLTHILTQLYSIFRDREATHLEINPLGRSLDGSFTSLNANFAFDKAAEHRQEEVSALRDKAQEVPDEVEAEKHGLVYVRMDGNIGNVVNGAGLAMATNDAIGFHGGASANFLDAGGKATKDTMIQAFRIITRDERVKAILVNIYGGITQCDMIAESIIGATSELDIQVPMVVRLQGTNSEKGLKMLEDANLGLVVESDFGQAAKRAVELAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V437</accession>
    <name>A0A7D5V437_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase atnD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atnD_1</name>
        <name evidence="2" type="ORF">G6M90_00g106590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539875.1">
        <property type="nucleotide sequence ID" value="XM_014684389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V437"/>
    <dbReference type="GeneID" id="26247314"/>
    <dbReference type="KEGG" id="mbrn:26247314"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="35683" checksum="BFA3A81AC9CFDD21" modified="2021-02-10" version="1">MSFPGFLYSQLIQRLPYPSGSHAGQTVIVTGSNVGLGKEAARHFARLHAKKVILAVRSLEKGEAAKQDIESSLRDAGGAGSTTEVHVWPLDMASYASVEAFAARANSELSRLDVLVANAGIASGSYYTAEGNESMVTVNVVSTFLLAALVLPKMKESARQFGTRPTLTITSSGVHAEAADLVARAAAAGELWPLVNDRQTVEAHFAAQYPASKLLEIFGVRAIGEQSPAAGFPVTINCVDPGLCHSELGRDYPTWGFWLLKLLLARSTEVGSRNLVAAGSMGQESHGKYVSDCVVAEPSAFLDSEDGRKVQKMFWKELTQKLDEIKPGVSGNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V497</accession>
    <name>A0A7D5V497_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450-DIT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DIT2</name>
        <name evidence="7" type="ORF">G6M90_00g107610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987823.1">
        <property type="nucleotide sequence ID" value="XM_066131733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V497"/>
    <dbReference type="GeneID" id="26243468"/>
    <dbReference type="KEGG" id="mbrn:26243468"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028932770" evidence="6">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="406" mass="45659" checksum="48164672DFF8C287" modified="2021-02-10" version="1">MTASLLLGGAILLAITVSGALLSCFSSPRKGVGGIPTIPFWVALMPLVKDVDQQDIFATYIEKPLRKHGAASIFFAGQWNVLIHKPAYLAEVFRREDIHQKSGNYSKIPHSVLAALLGDNIIWSRGETWKKYTRVIKPGLQASPNPDVLLRNARQLSTILVESQALPTDGIQGSIQRHTIACFENTYFNVDLNNKLCTRLLSARDSGQLTEKQFRDNLAVLFVAGQENPQLAILSTMYLLAKHQDIQDRLFDDLNQQPQNPPDAEYLDSLPLLTLAVHLGDAIFLPEGTYVGYNCYSTNRDPDAWGQDADAFRPSRWGCSRRDIHREYRRRRTRAEFITFHGGQRACLGEPFAVLQLKATLYTLMTSLRWRLDPTWLDRMTPRAEADQGEFLIGWAVVPKKLALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4C3</accession>
    <name>A0A7D5V4C3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">stt3</name>
        <name evidence="24" type="ORF">G6M90_00g102270</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987718.1">
        <property type="nucleotide sequence ID" value="XM_066131599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4C3"/>
    <dbReference type="GeneID" id="26240542"/>
    <dbReference type="KEGG" id="mbrn:26240542"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="21"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="542"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QLI73673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="748" mass="83892" checksum="B9D779324B9E645F" modified="2021-02-10" version="1">MTTEAQPRLDGVNTKSTRTLLRVVILLFIAGAAISSRLFSVIRFESIIHEFDPWFNFRATKYLVANGFYKFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGAIYHALKALTIPVDIRNICVLLAPAFSGLTAYASYLLTNEMTTSPSAGLLSAVFMGIAPGYISRSVAGSYDNEAIAIFLLVFTFYLWIKALKLGSMLWGALCALFYGYMVASWGGYAFITCLLPLHAFVLICMGRYSTRLYVSYTTWYALGTIASMQIPFVGFLPVKTSEHMPALGIFGFLQLIAFIEYVRSAIPSRQFQTFLVTILVATFGVGLIALVGLTSLGYIAPWNGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNFLIWLFPAGVYMCFQDLRDEHVFVIVYALFGSYFAGVMVRLMLTLTPIVCVAAAIALSSLLDTYISAKSPDPKEVESATEAASKKPAKPMAGLRGSEKPNVGIFHPSSKFVVVASVIVYLLMFVTHCTWVTSNAYSSPSVVLASRLPDGSQHIIDDYREAYQWLRQNTKKDAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMSSREEVSYPIMRQHEVDYVLVVFGALLGYSGDDINKFLWMVRIAEGIWPDEVKERDFFTARGEYRVDGEATETMKNSLMYKMSYYNYHSMFPPGQAADRVRGVRLPDQGPVLNTLEEAFTSENWIIRIYKVKDLDNVGRDHAAVAAFEKGHKKKKASKKRGPRVLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4I3</accession>
    <name>A0A7D5V4I3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">54S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g110130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987876.1">
        <property type="nucleotide sequence ID" value="XM_066131805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4I3"/>
    <dbReference type="GeneID" id="26243233"/>
    <dbReference type="KEGG" id="mbrn:26243233"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38362" checksum="5942F773CB9FE5D4" modified="2021-02-10" version="1">MCFQSSRLLNAGVPGHSLLSEKMVRGMDKATRPCLRLLLSKQRAPRQQVGRFKSFSSTTSFATASQATIDTAKFCPGDFDYAPVTKPASARPIDTRKSQLIRTYTSLLRTTPLMLFFQHSNLTAIEWAAVRRELKKAIDAVPKPSQHSGLGFADLSSRMQLQVVRTNMFSVALRIVEFHSPHVSKTSLSAQVASQGQPAHDLSKMAYEAIGEATVPADSAFAQLQPLMVGPIAALVLPAVSPAHLAAALTILSPAPGVFPAPTRKKSPGYHDPICQNGLAKLLLVGGRIEGQIFDQAGVNWVGGIQGGVDGLRAQLINTLQGAGLGITETLEGGSRSIWLALEGRRLQLDCGDEKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Z6</accession>
    <name>A0A7D5V4Z6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g112870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540350.2">
        <property type="nucleotide sequence ID" value="XM_014684864.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Z6"/>
    <dbReference type="GeneID" id="26246944"/>
    <dbReference type="KEGG" id="mbrn:26246944"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029012890" description="DUF7492 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="2">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30447" checksum="28569DB6A8D9DBAD" modified="2021-02-10" version="1">MLVRQIAVFHALIGLVCSHSWVERLMVIGTNGTMIGNPGYIRGAVSRLDPNFNDFKMQHLLPTIPEGLLTDKLCKNTQRNRTYTTDLPALQAAPGAFIALQYQENGHVTLPGLTPQKKNSGTVYVYGTLYPRDDELLSSIHNVWNTDGTGGDGRGRLLAVRNFDDGQCYQINTGPLSMQRQAKFHKTAMNPQGADLWCQNDIRLPVSIPFSWYTLYWVWDWPSSPSDHLPGGESEIYTSCMDIEIQPGVQLDEMNFVDGQDLNMAGIKEQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V554</accession>
    <name>A0A7D5V554_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lsm8</name>
        <name evidence="9" type="synonym">LSM8</name>
        <name evidence="11" type="ORF">G6M90_00g101930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987702.1">
        <property type="nucleotide sequence ID" value="XM_066131596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V554"/>
    <dbReference type="GeneID" id="90968181"/>
    <dbReference type="KEGG" id="mbrn:90968181"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="99" mass="10605" checksum="7EA58ACD6FABAAEB" modified="2021-02-10" version="1">MATLGGYLNKKVLVVTADSRILVGTLAACDQSTNLVLTGTEERVIHEADDNEPSEIHPLGLYLVRGDNVCSVGLIDESLDESINWTEVKGSEIGGIKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V556</accession>
    <name>A0A7D5V556_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump bik6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bik6</name>
        <name evidence="9" type="ORF">G6M90_00g094900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540851.2">
        <property type="nucleotide sequence ID" value="XM_014685365.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V556"/>
    <dbReference type="GeneID" id="26246464"/>
    <dbReference type="KEGG" id="mbrn:26246464"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF59">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="118"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="559" mass="60203" checksum="36A367B78CF2EB94" modified="2021-02-10" version="1">MSDKEKHDPEPPPPPPPAADNDVDSAADSGDDDEAKSEDLDGHRPTLREIRSNTSGATATGSLARRDTVLSRIRSRPAPTFTHPLAHVRTSEAELVGFEGPDDPYHPLNWATHRKASTTLLYGLVTMTATWASSAYSAGTGQIAREFGVGTQVATLGTTLYLFGFGLGPLLWAPLSEVYGRRAAVLAPMFVAVCFSFGSAAAKDLQTLMLTRFFGAFFASAPVTNTGGVLGDLYTPAWRGIAMAGYAMAVVGGPVLGPIVSAAVVEQPSLGWRWTEYLTGILQVVVLGAALVFIDESYPPKLLVYKARRLRHDTGNWALHAQFEEWDVGVGELARKFLLRPLQLLCTPICFLMALYASFCYGILYMQLGAIPIVFGELRGWRPLVATLPFLSILAGAALGCGLNVYNQTLYNRAYHAAGDRAVPEKRLPPMMLGSLLFSAGQFLLGWTARPSVPWIAPCLGLAMLGAGFFTIFQAALNYLVDTFQAHAASAVAANTFLRSCFAGAFPLVVGPLYHNLGVGPGSSITAGFAALLIPVPFVFYRYGRRVRAKSKWSRKSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLE2</accession>
    <name>A0A7D5YLE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g017310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985777.1">
        <property type="nucleotide sequence ID" value="XM_066129798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLE2"/>
    <dbReference type="GeneID" id="26238243"/>
    <dbReference type="KEGG" id="mbrn:26238243"/>
    <dbReference type="OrthoDB" id="4987761at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="88" mass="9389" checksum="E62CE89D21F619D1" modified="2021-02-10" version="1">MGNNLSSTFVPDTSKVVLSPPDAFGDILVVIIWGLVLYVCAMIFTTCALVDRWKGPMDRIRVGGGSVLAAMLLSTAWPVVMAYIVISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNH1</accession>
    <name>A0A7D5YNH1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PDX3</name>
        <name evidence="11" type="ORF">G6M90_00g024650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548117.2">
        <property type="nucleotide sequence ID" value="XM_014692631.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNH1"/>
    <dbReference type="GeneID" id="26237561"/>
    <dbReference type="KEGG" id="mbrn:26237561"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="249" mass="27778" checksum="898BE06B76114CEF" modified="2021-02-10" version="1">MALYRRPSQAKLIFAPAGSSPHGQAEQFTKSTLSRRDLHPTTPTPQFNSWFSQAQASSIPQPEACTLSTAELPSGRVSSRIVYLKELDAAGGFVVYSNFGTSRKAADLATNPHAALVFFWAPLQRQVRVEGVASRYSPGESQEYFDTRVRGSRIGAWASRQSQVLEPDGAVDGDDGRAQLEGWVADAEKTFEGREDIPVPDFWGGLRIVPTRVEFWQGRSCRLHDRFVYVREEGRDGEDDKWTLERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQG1</accession>
    <name>A0A7D5YQG1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g020510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548495.1">
        <property type="nucleotide sequence ID" value="XM_014693009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQG1"/>
    <dbReference type="GeneID" id="26237939"/>
    <dbReference type="KEGG" id="mbrn:26237939"/>
    <dbReference type="OrthoDB" id="4939929at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26507" checksum="83C7412190DD70A4" modified="2021-02-10" version="1">MRRAKSPSKLEEHKTHQGRRLHCFANRVTGENEKVDERAIVGKQLYLDVLGMSQGEQNQNATPDNLLQDAAKVRYELQSLSQMHNDAQSRLENIGPATLQRQPDNMTDFSWIDMTLRKLEAEIPPALWSSKAAQYKYDYIGSSKQVLSDAHQSPFSSDAMADMAVRDTLSQSDDASEQTEEELSEADKPGTSREEAVRPRNQPGDVSDQLPCGHEACGPRVSRADEKRAIVLGKQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR86</accession>
    <name>A0A7D5YR86_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g015850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985590.1">
        <property type="nucleotide sequence ID" value="XM_066129778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR86"/>
    <dbReference type="GeneID" id="26238387"/>
    <dbReference type="KEGG" id="mbrn:26238387"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="115"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="QLI63524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="731" mass="81089" checksum="BCF477A9D50FF959" modified="2021-02-10" version="1">MKRLQRCEAGGLPCEYTPAKRRFTNVRFQNASDAAGSSSNANNAPEANLSTSGTASRSDTVTSPASSTGSTNHNHFALITEGSNLTSEEMLVRRDILLRHVDAYMDNMYWLPCQGFLHPDTTYKEIQEGTFDPVVAAAVCGITAVFVSPSDSGGEFGVKCSAHVEMYLFQNIYKFSDDLLVLFALSITFNLIRGEFAKLWQSFGVASRLMLGLRVNWDVLPQNQTFAQQECLRRIAWQLFYLDRMLAGGYEEYISCRAENMQIALPCSEAAFRENRPINAERLYDKPGSHPSTINLHGYQLRLIDLRHRIQVTTKRLCSSSSPSQSQLDASKVMADVNRLQNELTRFHMSLPPEILLSDQTVAKYMASPERAGYVFLHTHLAVSHIDLYRFSLPGQRDKVSVEILRKLPREFIARSQKQAVAHAMCLGRFCDAIQNEVDQMHDTGKLKLAGDHSTFQMSTQCVRVLLVALQYGLYRDIADVTTAPLWRSVEVDEAHIRFLIDSVQRVTRPWCDILNVAQQAYNHNATLVEDFSKTRKVADQRAAVSMFGSKSEGSTRLPGPDAILESIATGKPEEYHRRMASHSPSDSTRWLGSHPSSPTPNMFATKAGTQTTEASQGDAAPGIPLFLAQARNRPGSATQDPLTYDAENSLMPMGDLDAVLPDTNPLMNVEGVPMSGMHSGDPSMFQQAIPQPSAGFLMAQQSVFGGDVFMEHYMNRQHGQGGYSQPPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRH1</accession>
    <name>A0A7D5YRH1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g051500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539835.1">
        <property type="nucleotide sequence ID" value="XM_014684349.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247390"/>
    <dbReference type="KEGG" id="mbrn:26247390"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="416" mass="46606" checksum="0F90B312ED4D802D" modified="2021-02-10" version="1">MARVRLDAWDKMPQLQKLAGEYMGFEDVVQKTMTIAEKLKKVRANTQTLPRTRPRGRDYVSKLRILTPGHGPPQKAEALIDSSVKYNFVSKTLVDRLKMPTQRTLPTAPEMTFFQGDKARPRDETWIYFSRDGRSDYFRDRFYVLNQAPVPYELIIGSNFHQDHGRVLLEPPPLALAAARADEAVIRRLLKQVVDVEARDAQGSTPLHHAIDSDSPHIVQLLLENGADAAATDNYDIMPLHKAAARGNEAIVKLLLEKDVDLEAKNPYERTALLDASYKGHEAVVKLLLDKGADTEARDFASATSLHFAVQERREAVVRLLLEKGADTEAKDFFLNTPLIYASYRANVAIIKLLLEKGADFTVKDRHGQVPLRTAVDYRRESVAKLLVQHGAYVDESNLSEAAKAFLDSILGPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRQ3</accession>
    <name>A0A7D5YRQ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DUF221 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g046710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544796.1">
        <property type="nucleotide sequence ID" value="XM_014689310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRQ3"/>
    <dbReference type="GeneID" id="26242137"/>
    <dbReference type="KEGG" id="mbrn:26242137"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="207"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="409"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="783"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="733"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="100314" checksum="EF0AE92A54A95A64" modified="2021-02-10" version="1">MGNFISWINENVPSGEDNGNGQSDSTNKPQSVWGMIDTLIPVLIVSAVYLIFFLIFRRSQRRYYAPRTYIGGKSERSPEMPSGWFNWFGAFWKIPDTYTLTHQTLDAYLFIRYLKICTVICFVSLCITWPILFPVNATGKGGQSQLEILSYSNVNVDESPNYFFAHAFVAWAVYGFVMYMITRECIFYINLRQAYLLTPHYAKRISARTVLFTCVPKEYLNEAKIRQMFNNAVNNVWIAGNTKELDEKVEERDKTAMKLEGAEVKLIQAVNVARTKALKKSGNNNESEQDTETADIISRWVPDKKRPSHRLGPLGLVGKKVDTIEWCRSELEKSIPEVEKTQLGWKQEGNFEKVGSLFVEFHTQADAQAAFQVITHHHALHMSPKAIGVKPVDVIWKNLSIPWWQLILRRYAVYAIVVALIVFWAIPVGIVGIISQVSTLVKLPGLTWLNDIPEKILGVISGLLPAVALSILMSLVPVIMRALSGVAGAKTNTEAELFTQNAYFCFQVLQVFLIRSITDAASTAIVQIAENPGSVFSILGSALPTTSNFYISYFIVQGFTIAIGVVTQVVGLFIFRLLYKFLASTPRAKYTKWTTLSAILWGSLLPVYTNIVVISIVYSVIAPLILFWSTLALFLFYLAYRYNLLFVSDTAVDTQGLIYPRALKQLFTGLYLGEIVMIGMFSVVKSPGPAVLMAIFLVFTILFHITMTRSLNPLLYGLPRSLETEEAIFQTRGTEIDAEEADRETSNEGDVTNGAKAGSSTKKILSGGNDYGVEKKGNMFTRFLKPWVFADYATLRHIVPQEQSINFAQLQQAGEENERNAYFPPSVNSQPPQLWVPRDPLGVSKHEIALTSRVIPISDKGAYLDEKNNVVWSEDLTNEEELPPIHDEKVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSA6</accession>
    <name>A0A7D5YSA6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein CAP22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CAP22</name>
        <name evidence="3" type="ORF">G6M90_00g032400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543173.1">
        <property type="nucleotide sequence ID" value="XM_014687687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSA6"/>
    <dbReference type="GeneID" id="26243974"/>
    <dbReference type="KEGG" id="mbrn:26243974"/>
    <dbReference type="OrthoDB" id="4961454at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028832080" evidence="2">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="189" mass="19412" checksum="4B75F398B83B46D7" modified="2021-02-10" version="1">MHLSIAIIALAIAAPVVIAEELDANDVPPACAVICRPIVSLTNMCDINPNEKYDDDHMGKRQLLDARDADDPDDRIEAECICKNKSFNVPTVMALCASCIAQNGRKTEDINEIMSQCSFSSVSYAPLSTGIVSGIQVQATKPAGGNTPAQTTSAPAATKTSGAGGVGKLANSAMAVVGVVVAVVAAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSG1</accession>
    <name>A0A7D5YSG1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinic acid utilization activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">qa-1f</name>
        <name evidence="4" type="ORF">G6M90_00g005240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542171.1">
        <property type="nucleotide sequence ID" value="XM_014686685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSG1"/>
    <dbReference type="GeneID" id="26245202"/>
    <dbReference type="KEGG" id="mbrn:26245202"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="726" mass="80253" checksum="75F34FF480CFBAD1" modified="2021-02-10" version="1">MPQKRRARNAAATSNDTENGGKSKKRRVSLACDACRAAREKCDGARPECRTCISQQRSCSYTPATKKRGVQTGYLRAIELSLAWIFEQMPECEERLLRFLSRGDRDATKDHRALLGKGIAGHHLQRLWNQNRVRKAVDGLLSDAQINNSEDSGNDLDTDGESQANALDATSRRSGESVTVPRMVQDPESAHERRLRLPTNWKRLLDVYVSYTHCWLPIVNLDPLRALASSYPSQGIRICSNVHDGSYLRHSELWAVLTIAAYQDGGYTEGAGSRSPNISEIFDVSHTLIPADDGGFDIHSINAMIIHSVILIGKKKTLAASLLLGKSARLLQRLRLIEDVTTQEEGDFYLIQHAVVSLACSFLDVLTSVFLHQHPMRGLSHIKGTRQVEAADFADFDQPWVPVPEISATSTSSTIPPQIAQPIRTLTQLHAFASVLSDHLTSHMSGENLPGVTGPEVLVKILDSRFNYCNSLISSGSTPMIPSAYLVKLLFLTATIELTSNPRSSLLSGFLEIVESCFAVFGAGHTPPAVVLLLQIVQRRADADEMGESGIRKWRSITERLQNIWREREPYAYTLDEPPIYSSEVTEPHNLRQIIFTPIPTGTDPDAKGHAGSQPRDLGVKALTDHEPAQQFRFGYQDAIPNPAFAIDTPITTRLNRGSANTANTHTAMFPGNHRMSQSFDYDAILEDFGSIGYTDNIEMDTRFMTNLGFAPGCDLAEIFQGDFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSW1</accession>
    <name>A0A7D5YSW1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g018720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548668.1">
        <property type="nucleotide sequence ID" value="XM_014693182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSW1"/>
    <dbReference type="GeneID" id="26238112"/>
    <dbReference type="KEGG" id="mbrn:26238112"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="385" mass="42006" checksum="B065F5BC9DB74A55" modified="2021-02-10" version="1">MSIDNKPNPPRDESDDSADSTPEREQNNSATVSGNSNNAVQDAQQPKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLEETIRIHESNLHNLQSAHRNAADECLMLRYKNSLLERILLEKGIDVQAELQAKAESPNLGPAHVPQNIVQPPPIQRPIMNRQHHNRKSNSSIAPKLEPGSGAVGSAMQAPKSATSPKNRPTPSSHSNSPNNAASTFSPAPSDSISMRGSISGLTRQHLSLGGTTQPSRSTVLQVATPRSVAGTGASYYPTPAFQNHVEQADHDYDSRADMVDDSEIETPSGHGSFGGAFNSDTTQPMLLSPTSTGPAHHEQGGHQASLSNHHFPSMTQLLDHQNLDWDPFGLSASMAFPNQQFPFDQSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTN9</accession>
    <name>A0A7D5YTN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g054320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540972.1">
        <property type="nucleotide sequence ID" value="XM_014685486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTN9"/>
    <dbReference type="GeneID" id="26246278"/>
    <dbReference type="KEGG" id="mbrn:26246278"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="190"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="470" mass="52631" checksum="DA0C3A399A7C8072" modified="2021-02-10" version="1">MSSTLLPFLYQTRTLQRAICVQPVTQFIRLAHAPARPKSRRRDNFIPFEWDHDTPYEEIANVPGQQSTITPSEAEIFKGIFDDIAQGKMPVAKNRPTPSEGMQIQSENSQESKPGMARSIVEQARVMEFREKFLGRYPPSLRNAAQIALGLYELEPSDSSASEMVELEEADQAKWEERARYERARVEERERVDGLMKACTTDGELWAVMEKEVFSLPAKLGIWQRKAVRAKNKKVKDTKKSATNTDGGETMESTRTADSKQTAEAAKKTKRKAKGEAAGNTEPKAREESTRNTKAKGPEKSAAAGKPATQAAADEEKRVMDVHGPLYPYFINTAMGLFDCAFARPSDYAFQILPRVKDLGLPSYVLGVSTPFYTRLARMHWNRFGDASSALDVLQEMNSAGLYADKDVYDLLITIRDHLHGCTWGAQGPFVMGMMEAPPYDGMLTQRLEEMERYAVQSMSPTGEQVEFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTR7</accession>
    <name>A0A7D5YTR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily multidrug transporter mfsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mfsB_3</name>
        <name evidence="9" type="ORF">G6M90_00g058580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544433.2">
        <property type="nucleotide sequence ID" value="XM_014688947.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTR7"/>
    <dbReference type="GeneID" id="26242845"/>
    <dbReference type="KEGG" id="mbrn:26242845"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="18"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="554" mass="60605" checksum="1F76E546ADDBDF55" modified="2021-02-10" version="1">MSDDDSHAPPRPKLPLQQLTILAVARFAEPLATTSIYPYLPQMVRDFGVEEAEVAKWAGLTSAVFSVFQSFAAVPWGKIADSWGRKPSLITGLVCTMACFVVWGVSTSLPMAITVRAIQGASNGNVGIIRTMVAELVPEKELQPRAFSIMPLVWSLGSVVGPAFGGFFADPAKQYPSVFGGVWFFEKFPYALPNLIATVFFLISVTSATLFLKETLAAKRDERDWGLLFGKRLGRALKWNKKQDRRRRSFVDGEATAPLIPNQIRHKTVHDSSTPGTLEIFTQQSVLIMLAYFFLAFHSVAYDQNVTVFLNYPVKEHTPENTRLPFYFDGGFGLESGRIGTIFMLYGVTCGLVQFILFSPMVTRWGVLNCYKACCVIMPMVYILTPYTSLFPTPETRLMGLAFVLMLKAFSIIVAFPSVTILLTNSAKSLRILGTLNGFVTMFSGFGRALGPASTGLAFTWGAKHGYVVTAYFFLAVIAVLGAIPVFWVVEGNGPTASVENSDTEENETPVSSRILVDESAIDDSDAESHESEPLLGNSKKGAPYGAAKIGCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUP6</accession>
    <name>A0A7D5YUP6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate-dependent ethylene/succinate-forming enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">efe</name>
        <name evidence="5" type="ORF">G6M90_00g026510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547936.1">
        <property type="nucleotide sequence ID" value="XM_014692450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUP6"/>
    <dbReference type="GeneID" id="26237380"/>
    <dbReference type="KEGG" id="mbrn:26237380"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="174"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="40181" checksum="013339CB3E409BB5" modified="2021-02-10" version="1">MPPGFSAAVAQLETFVLPERLSGSLSDRAMAKAMVRAWRRHGILQIAMSPSQQQIYAQANAASRDFFKATPLQKQACVNECSYAGYVASGEEITAGVADYSEIFTVTKDLHPEDPRVLEKWPCHGPCPWLDNRMKSPMLNYMADMGSSGDKVLQLIELGLDVPQGSLTKYTDDGWHHMRVLRFPARHRTNGKGKAGRGIGSHTDYGLLVIAAQDEVGGLFVRPPQQGESFANWKQSVAGMKEDEPGWLYVPPTPGVFTAFPGDMMQYMTNSFLQSTPHKVGLNVRERFAFAYFHEPNFRAMVKPLPGFNGSQEPADGIHYGTHFTNMALRNYPTRITTTKLLEEGRCEMLSKERLRDEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV22</accession>
    <name>A0A7D5YV22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Telomere length regulator protein rif1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rif1</name>
        <name evidence="9" type="ORF">G6M90_00g057560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544337.1">
        <property type="nucleotide sequence ID" value="XM_014688851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26242749"/>
    <dbReference type="KEGG" id="mbrn:26242749"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="159"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1184"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1200"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1218"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1240"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1350"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1373"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1439"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1583"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1639"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1655"/>
            <end position="1667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1764" mass="195238" checksum="9AF1CF1AA1DE1084" modified="2021-02-10" version="1">MASSVASASSSNILIALPARPPTPPREASHEVDVSLKSIVLGRASAFDPILSLHTPPNAHSFTSPVATGSNPSSSRARKKVEWSSHTDYREAPQYPEGLKAVKSSPFSAPSSATRFKPVKSILKPSSSPNPLASCFTNELDGPSPLNIIEMLDSTIKQLAGADRDSKLDAYMMLSRALKASNNLPDRVALQNKMSLFMQFVQRDMTAKSDHGNLDTSLINHSLTLLATFLHFPAIASTLTSDFSVFVVEQSIRSFEDEAMPKDVIRHLMQVMAFQNFSAKVMTSERVGRLIAALHKIEHHLKGKSIIMSRLHIYKRLIKQSRNHMAAHLDWLKDMFTDMLSSVKDIRSQAISLGSEAGFALRSEKQLLRKASELFQAANDTETYIDFYIKRLQAMVKEKHCCHFVPQIWSVVILFLRCPLDRWQHYGPWLTLVQSAFNMTDNSTKQEANFAWNRYLYLSLSDNRVSPKCIATLCQPLLSQLRRKSSAKQPEEALKLRRVVIGGICNLYYYAFTPGSDKYDTDVLWDVAVQPIISQLISLDGMPDVPGDGIMQAARLLVGLLDVVTPRIWRQDRIVDLPPVKPDELPAIDSKWVRRNCDKVLQLVGPVIQKKFIDLANKDSLIYRLWQALVGSVAAASAKDIKVSEDTAKFVGCTFGLLSTVFTAENAEPESTSSNSKFLSGVSNFVQILIDGLGLLPFTEKRLSMTVLNTFEPVATPSQRLDRSDKPRGVVRMPLHHLFVMLAAVPVGGSDDDALARFFQSIFEPFLKGRSVKGRFDLAKELLQLLPRNSLSPYGPWLLAADCAKACLDKRSVLTAGCIPVPDKMNGPEFREIVSLIERGLSSHPNLPPRQWTPFFETVATQVSSDFGDAGCSLVVIEPLAKAILDMPGAATEGLSPLIIQAVTSLFNYAKLPRDKQAVESARSRLWGAPPTLPKMTLFDPLDHLYKLGNHFLAALYDQQLDTDWNVRAVPLLEAVDTFLVKNWPLFGIEVLSKLQTGLGVWLQNEKTHIQEKHESSLFTCVATIWDHVCSNLAAQERPNRRSLDVIEPVLTAAFKSTHATIVNRTCVMWNAIMKGDEDIQCSDSLMAIISSVRSKVDIVVPGASRSTGIGILTAKGGPSADPSSDALSPTRSHSDPNIVASASRLSASRRPMTRRRRLESTPEFHHAKSTKRMSTPRRRHHNSQIQFEPIDSSSPLHNESQHLTERQKEVRERQRQNAVLYTDVQSSFSPPSAHKLPGPSTQRNAPQSPQVAQESTPKHSKSFEDLISLTPTPRRGQVLQMDDFNDPPSSPPAPRPYPFLSEIQSRSRAGSVMESWEFSSPPGSPLDIQQREESELQPTGPADIESPKKLRRYSKRKRRMEAEACQSNDHAVSNKREDEGVLSLKAKDQPSQRSLTAPATPGEGRITRARTAQVTPKLENGSAKGSKSLSRRCSSRCVEAENKTTEQKVDGTKSGAPSDLQDAAQHGKDATRPIDGSQLCGRIEGGSKTPLGSRGCILVHTDSTCPSPEKPENATVETPAPVIPSTAEPSEKTETSRSRRKRKRAGKQSDKGNKRRRSGTDEIQELSDREQSESEPSVPQTCDDKNDPIEGIETRRGLRQRQQQALLRESRQAQRDAKHRAKSPCGNMDGGDTDEEVQSQLVKESNEASQQNHLEGDDQGANKDEIAGGANEDEMELEVEPAVGETMETFVGTKSSAGPPVGGESPLTIMETLRSGLDKLRSASLSREKVYEVEDILMDMKRELFEAERRGRGRTRKRKSRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV32</accession>
    <name>A0A7D5YV32_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl-5</name>
        <name evidence="8" type="ORF">G6M90_00g104590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987560.1">
        <property type="nucleotide sequence ID" value="XM_066131649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV32"/>
    <dbReference type="GeneID" id="26245702"/>
    <dbReference type="KEGG" id="mbrn:26245702"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="239"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="302" mass="34426" checksum="80F75171AC9A93C3" modified="2021-02-10" version="1">MPFHKLVKNSAYYSRYQTKYKRRRQGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNKDIIMQIVSAEITGDKIFASAYGHELKAYGIKHGLTNWAAAYATGLLVARRALSKLGLDKDFLGVEEADGEFTLTEVAETDDGPRRPFKVFLDVGLARTSTGARVFGAMKGASDGGILVPHSEKRFPGYDMESEELDSEVLQKYIFGGHVAEYMETLADDDEERYQSQFQKYIDDGLEADGLEDLYTEAHAAIRADPWKKAESDGPKKTKEEWKAISKKYRQTKSTKAEKEKRVQERIKAILAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVL0</accession>
    <name>A0A7D5YVL0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g068920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986995.1">
        <property type="nucleotide sequence ID" value="XM_066130890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVL0"/>
    <dbReference type="GeneID" id="90967904"/>
    <dbReference type="KEGG" id="mbrn:90967904"/>
    <dbReference type="OrthoDB" id="4941419at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="784" mass="88041" checksum="52D322515F4E7092" modified="2021-02-10" version="1">MPENGTARCVLPTIDSQRQLQDLVLRLQGMENRRFAPIIPFFSAFSDYMYFLMRDKTVWTAEVSLTSAAPDADVDDQGRGSRLVAIHRESFHPELTRAVRHSMHLGDVRYVENRLPGIIVTSDLPWSQDERRGAVYVKHKFSKTRALIWFCCGLVASNLNFTLPEGTTNHGNPHLLCFPTRWNDIAVFILGNYVAHAATVKTPPASSPIATAWFMLGSLLVPSTGLAFGMLAIYQARKGFKQSSLRKATLARALCIYVRADDWYIRSCSSSQTVQVKAMVNTSPFQENRLTIWRLFHAVSRQGSSVMWSLPALFRLYVSLSFDLTARHLFCMMQAIGNSHRQQSERIQPVSEDVLSSDRYVQEHVYLPDLLLIISSASTVVGQSGSQQPIETAVIYTTQASDLVNTDSEIYGQCPSVPGYLLAHVPINSMVEPAAEPCDGLTALKLLSKRRNATKSLVALLQLCYSIFVLIRAEGNQVDLYGSAAFSLTVAPYAVMAAVNLLANALVPQYDCLFLVENDVMQEIRSQHNLQFHGIVGKVLQTEEGEPVTLHLPGEEDGGQKWVSGIPGFQQDARLRLLTPDEAISDGVLPDIFVTISASHEIEREGVSARRTLLLITLFFGFLPVVIIVAISRFRKPTEDVYTQWVVQYMWTGIQQYLGIMIANQIFLSQGKAAVPAPILRKFWSNNNRLLTPESFRRLGFHNRVYGSLHHRMIRLLYRIWIRANTLPLSLLTLLRYPFSRKIFPQSASRNRHNNYPTLYLALPHVAHQPTPASIAKEPHYLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW05</accession>
    <name>A0A7D5YW05_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g084360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543651.1">
        <property type="nucleotide sequence ID" value="XM_014688165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW05"/>
    <dbReference type="GeneID" id="26243828"/>
    <dbReference type="KEGG" id="mbrn:26243828"/>
    <dbReference type="OrthoDB" id="4940875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="483" mass="54560" checksum="75DB9B822A4A8E62" modified="2021-02-10" version="1">MNTTTSTQIFSPLDAANLESIGLLGPVETDGKRKCHKRRLNRSSDEEHKDIPLDVSIGSPEAEEADAYATIPDAIFSRETLNYLGFSTHMADTIWNGWVNWPLDGPGREVDAATGGLRVTFIDFIILRHVKKANNVYEDDDFKWRQCLNACGMSDSVQNAIMDENFKEIRMSRSCVYWVTDTVQMRYAGLKEIQRASRERDMQLQRERARQGGPSRRDRTSSSMGSDQSGSAQRRGHTRGSSSQGGRSFSGAQADSTPGIHSELWNPNIIRRAQVDPQTLILFKGIDLGRIPDLLNPDGTVQNIMALSSPPPSDFSNSTALFYFTPEMEVAEYYAAYAKRRAGCEAVVMVTCHIPKQVINDMKEPNIFRLYYPTPQWKQLVWRSRSNQPFTKPLRKYDDAMLIIGNISSGDNDNYRKLASWEEIDGSCLLRVKRMGQSNAQISRQYAFTGRLAGQDLLTENGKFNAYRFSDEHITALISRHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWJ0</accession>
    <name>A0A7D5YWJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g036130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547006.1">
        <property type="nucleotide sequence ID" value="XM_014691520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWJ0"/>
    <dbReference type="GeneID" id="26239569"/>
    <dbReference type="KEGG" id="mbrn:26239569"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="295"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="545"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="718"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1081" mass="114437" checksum="69B6F5D4C39D3ED0" modified="2021-02-10" version="1">MADKENIDVAQSSDVAPSKETTPISPETPSKASAASTSPTARRAGATTSSASARRTTATGTAASSRTAAGSTAGARATGGLSKPPTRPPTTTTATSRRPATATSTTSTHRSRPSVSASEDERRSTLTSTSARRTSTLMSSPGRTAEKKATTGTGTAGTARKPATATASTTGARPSTLGSRSSTAGTTASARSSTTAATRTAPKRLSTSGATGRVSATASRPTTARSDASSGAKEIEELKAKLLEGDSEIESLKAQIQSSETIISELRDQLANAAPAAETEAMQSSIAEEALANLKAEHESALAGLESRLSEVVQKLETAESELDQHKTNLATAEGSKAAIESEIEALRKSLETVQLENDEKVKASESALQQALDGHATKLSELKDSLSEQHKTAIEELEVSHKNELEKGQTDASAHEMAIAELKTSHESIVAQLQSKIDELTASQAALESASNEKLRSDQQAHNSRVAALEGEIAELKALSDVSGKSAESATTQLTELQNSLAEKEKELSSIAEDRSSLSTKLTETQSTLADKEGEIAKLKTMHDERMKNLSQDYENEIESLRGDAFFKRKFEELEGQHNELKTSSEEATKAHSDALAVSKAEHAAAVEALAAREQEHQKNLDALRASHAEELESAKTGASADKDAHISQLESLKAQHAEELSILKKESEATLAKQLEALASTHAGVLNALKQEHADEHQKSQAAYDEALSVAKSAGNDAHVSELASIQAELQAAKEQLEQARDDGELAIETAKNELEEKHIGEIEKIITMNTEAMDKMKADGIQARKDLEELTATHAKSIEDAIAEYRSTSSSLEEKLAEQKAANGSMESALKTAQEALTKAQAEVEEMGQQLAQEKMERMTALAELDAVKSAKPDTSEADALRKELATLKKTHEDAHAAAEGALKGKEDELESHKAELAGAQDSLASMKNDLALAQKELEAHRSEADAKHKTALADYNDLNDSMTSLVEDANNKAKELEARLGEATRKAEEKEKKIEELEAQLKVRDAEIVEARANGGKSKGLSSSRFAGAESGSDEAVANEDVAEGEDDTNGIGGDDDDDDADDHSSAALASVREPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXR1</accession>
    <name>A0A7D5YXR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">KU80</name>
        <name evidence="21" type="ORF">G6M90_00g015760</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985624.1">
        <property type="nucleotide sequence ID" value="XM_066129777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXR1"/>
    <dbReference type="GeneID" id="26238396"/>
    <dbReference type="KEGG" id="mbrn:26238396"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03731">
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    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016570">
        <property type="entry name" value="Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="20">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR016570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI63687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="719" mass="79678" checksum="EEAED524CFD254DD" modified="2021-02-10" version="1">MADKEATVFILDLGASMAQKHSGREESDLDWAMCYVWDKITDIVAANRKTLCVGVVGLRTDETNNRLQDGDGYENISVIQELSQITMSGLRALKASVKPNETMSGDAVSAIVVAIDLIGTFTKKLKWIRNIVLVTDGQGEMDADDIEDIAKKINDSGIKLTVLGVDFDNPAYGFKEEDKPPTKAASEHTLKALINQCEGGTFATMAEAIDELDTPRVKSVKPYKTYDGALTLGDPEKFPAAMNINVERYFKTHLARPLTASTVVVKSDQATQSTQTLEDDPMDGIEFSAVKQARTYKVNDPDAPGGKRDVEFESLAKGYEYGRTAVHISESEHNITKLETEKSFSIVGFIPWTKYEPFLNMGEVCVTHARKNDTKSELALSSLIWALLELESYAVARIVTKDGKDPLLVLMAPQLELGLECFYDIPLPFAEDVRSYQFPPLDRVITVSGQTLKTHRLLPSDELAKAMSDYVDAMDLATYGQDEEGNPAEYASIDETFNPAIHRVNNAVKMRAAHPDKPVPETPASLLRFSAPPEDLIEKVQPRIDSLIELADVKKVPPKAKGRRARETVKPISGLDVDALLGEDTKRTVSEENPVPDFKRALGTADEMDQIEDAAKQMGNIVRSLITDSFGDSKYAQATECLGVMREELINMDEPEMYNTFARDLKKALLSGALGGDRRDFWFKVRWSRLGLIDQDQSEVSKVTHEEAEEVRAHIVLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY72</accession>
    <name>A0A7D5YY72_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphopantetheine adenylyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COAD</name>
        <name evidence="2" type="ORF">G6M90_00g095120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685383.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246482"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="445" mass="47874" checksum="C81B72312B20BE13" modified="2021-02-10" version="1">MSCTDSANAPSLLLLPSPPDPATPDAVRAAYRRPLEAVISRLSHENRPNASRDIAPVLVVAVASPVLTRGNPAATSGHDARSVDWAPSQSLLADLYSLVAVICAEKSIATDLEADDPGAVDVRLLLIDHDQSAPSHYRPGPNGCYEANNTTVLDLAAFASLVRPWRHIFHPSSEAGYQLHAAYLKYAEGKQRFLQSQLVAVDGGLTLSQPASSQGTANDAASVSEPRTSRQRKHSAKSYTTVCLGGTFDHLHPGHKLFLHAAILLLNLQDNPSGEEPPCELVVGISSDELLAKKKYADQLQSWDVRSRSVINFLSTLLNWSTTSATAMKAVQAETKELHATFRNGRILVRCVDFHDLYGPTVKQESIQALVVSGETRSGGQAVNDKRHSQGWPILDIYEIDVLDAGIGPVEGSNGNTAAAGGNFESKISSTEIRKQKAQRLADSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ18</accession>
    <name>A0A7D5YZ18_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547861.1">
        <property type="nucleotide sequence ID" value="XM_014692375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ18"/>
    <dbReference type="GeneID" id="26237305"/>
    <dbReference type="KEGG" id="mbrn:26237305"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028983272" description="Hydrophobin" evidence="2">
        <location>
            <begin position="17"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="10868" checksum="710CD3EAEC15C24E" modified="2021-02-10" version="1">MKFTAAILVLAAAVMAAPYDNPPPPKPNHTPGPAPGPAPGPAPGAGDKCNNDQKQVCCDKVIGLVCNLGLVNNCGGGKTYCCAANAPTTQNGGIHILDLNVGSCNRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZQ0</accession>
    <name>A0A7D5YZQ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g000080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543055.1">
        <property type="nucleotide sequence ID" value="XM_014687569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZQ0"/>
    <dbReference type="GeneID" id="26244428"/>
    <dbReference type="KEGG" id="mbrn:26244428"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62754" checksum="7DBC9E468AB00219" modified="2021-02-10" version="1">MQARGESGPEEEFTKLSRASVCNWDDTSRYMDYLRTFCVLIAYDAAKSNGQKAWLNIGLSKSLAQLYRAQGHHAINDVQDLENIEMYLETVETTHCLGHSALQTSILHRPLAQPASTDQRTRDKPVVRLVNLLKLLIRIKKHNDTCASTTQGFQPWKIESEFRELQNEVERDRLHYSNTPFPEHEELSENEDMADAHAEAMCFLVCHCCDIVLNLRFLPIPESRSTTGQGVDTSPPCIQFPGAPPLFLLERRKRCEASAEAIVCVAQEIVRNGGFFLHTALLGYCCMQAVFVLINQLHRLTKQQESEKLVESTEFILFLLEAVKKFYSPAGIWVDTISHAKDVSAPLTHQNGTVDDAFRSYFSRFTNIKEPCFVPIASKEGSNQDSAKLNNDKLSSSLATEPKSTADIQGRNNDDAQTVWVDKYASHLSEDIEVGAQDEGLGETPKIIFDDWGHAGPDLLPLSASESRSNTLPTTASDNSHALPSQEKLSSIVRHDEYQWNGLDLGFDAGSGAPITGIGLGASMQLPSSPSWLPAVSFLWQEPTLCELPLVLTPEIFSELIAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZU9</accession>
    <name>A0A7D5YZU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">msh6</name>
        <name evidence="13" type="ORF">G6M90_00g095160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546814.1">
        <property type="nucleotide sequence ID" value="XM_014691328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZU9"/>
    <dbReference type="GeneID" id="26241237"/>
    <dbReference type="KEGG" id="mbrn:26241237"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI73981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1223" mass="137115" checksum="4458F0B327A7C009" modified="2021-02-10" version="1">MAGDKASSSTARTPAKPAPKPTGSASASASAKQRSIMSFFQKSSPVGRSSPAARDKVSPDPQHSSCLQETTKANSLPKPKPSTKLSTPVPSSDAIEPPSSQENADPVTATKTTSSTLLSPTTMNPRTRSTNDVTPKAVQSGTPTRKTKKVVSYAESSDEEQPFNYSSKSQTRRGRARRTVKDEDEFDEDDVASQEAEEDDMGDFIASDDSDDLPRTKKRKRPAKAATARKRSNVSPPADIRQGSPIHDVDDELMTDVPTTSTTSQWNYDPESTEKRPVVTPAERAAAKDPKRKEKAYTKEPEDRYPWLANIRDKEKRAPSDPEYDPRSIYIPPMAWNKFSPFEKQYWEIKQNLWDTIVFFKKGKFYELYENDATIGHQEFDFKMTDRVNMRMVGVPESSLDHWVNQFIAKQYKVARVDQMETNLGKEMRERQDRSGKKADKVISRELSCVLTAGTLVDGGMLQDDMAAYCVAIKESVVDDLPAFGIAFADTATGRFQLSGFTDDVDLTKFETFVAQIGPRELLIEKSHLSTRALRILKNNTSPTTIWTHLKPGTEFWDADTSRRELKCGNYFTTQESEDDVWPEVLQQYKDDDLVMSAVGALVSYLKFLLVERPLLSQRNFEKYSPIQKNGTLVLDGQTLVNLELFSNTSNGSSEGTLFSLLNKCITPFGKRLFRQWVAHPLCDIQRINERLDAVDMLNADPTVREQFASQLVKMPDLERLISRVHAGACKPEDFVRVLEEFEQIEYTMSLLQAFKGGNGLVDRLVSSMPDLEEPLTYWKTAFDRRKAREDKILIPSRGIEPDFDDSLNRMEEIKDQLNDLLSEKKGELKCRTIKFTDVGKEIYQMETPKSVKVPSSWRQMSATKDVKRWYFPQLTQLVRELQEAEELHSQLVREIASRLFQKFDVDYNTWLLAIKIVAQLDCLVSLAKASNSLAQPSCRPQFVDEERSFVDFEELRHPCMINTVDDFIPNDVKLGGDQAKINLLTGANAAGKSTVLRMSCVAVIMAQIGCYVPAVSARLTPVDRIMSRLGANDNIFAAQSTFFVELSETKKILSEATPRSLVILDELGRGTSSYDGVAVAQAVLHHVATHIGCVGFFATHYHSLATEFENHPEIRAKRMQIHVDDEERKVTFLYKLEDGVAEGSFGMHCAAMCGISDRVIERAEVAARDWEHTSRLKESLEKAKTGCYIPLGILSDIGSLLGGKGDIGDKGVDVLLKAVECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z036</accession>
    <name>A0A7D5Z036_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ubc7</name>
        <name evidence="18" type="ORF">G6M90_00g020370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65086.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR016135">
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        <location>
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            <end position="165"/>
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            <position position="90"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="166" mass="18703" checksum="64C510204968AF31" modified="2021-02-10" version="1">MAQSTAHRRLLQEYRALTNSPPEGITAGPVSEDDLLHWECLIQGPEGTPFEGGVFPAELKFPKDYPLAPPTMKFLADMWHPNVYPSGLVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKMWRERRADYENKVRDGVRRMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0K2</accession>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
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            <begin position="125"/>
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        </location>
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            <begin position="133"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI65887.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="189" mass="19868" checksum="6237576155AA4C55" modified="2021-02-10" version="1">MPSFRTIFLAVAASFSAVANADYTIDPDSVPIGTRKAWCDQEMTTCPLICQQVEPRTTIDNTCDPESLTYGCLCGNNLQPNVSQYSLSLPYFVCTQWVIQCKDACPTDACKSDCQQKHPCGAQDPVRPNATKTAGASATSTGGSNTIYTNAPGGGSDNGKKGAGAALEVGRTYGLAFVLTSLFAGFALL</sequence>
</entry>
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    <accession>A0A7D5Z1D5</accession>
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        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">G6M90_00g044960</name>
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        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
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            <taxon>Dikarya</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="179" mass="19723" checksum="0B8861AD17FCCFA5" modified="2021-02-10" version="1">MAYEMVSPQGQTIVHQQHVPARRGMSRWWPVSFFIAAIIFFIIGGGLMGAWAASFDGYAYYTDGNWYGAIACFVIASLLKLTAWILLIVWCVKGRNRAQPSTTVTYVNPPPVNGAYAAPPQNYFQQPYNEDPTKSQAPAPVYQNVEPVPMQYGETARYCGNCGNATTTPFCAQCGGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1D9</accession>
    <name>A0A7D5Z1D9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MGM101</name>
        <name evidence="11" type="ORF">G6M90_00g040300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547379.1">
        <property type="nucleotide sequence ID" value="XM_014691893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1D9"/>
    <dbReference type="GeneID" id="26239942"/>
    <dbReference type="KEGG" id="mbrn:26239942"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="399" mass="43433" checksum="58678D06D1B557F7" modified="2021-02-10" version="1">MAQDQGKLSSMTEPVDDDEPDEWDKRIFSTGCADENMKMTDCYFEKKDWRACAAELPSSPPPPPATHLQTASTSTPPGHSPAQHRRRRRRLSPTPPDPVTCAQTSPHETMMLSRRAASAAARALATGAPSLPLAARFHATEASAPAAQPSPTPASPTPAAASKPAPAASKWAKAKTAAKPARSASTSSSTSSALTEADVIYEPRTIAYRAEGSQPPLDAASIPAVDWANSFHGISSRPVTEEQFRALMAPLAIKDIEVKPDGVVYLPEIKYRRRLNEAFGPMGWGMIPKGDAVVGNSIVTREYALIVDGRFVSQAQGENAYFSPDQLPSSVEGCKSNALMRCCKDLGIGSELWDPHFLRWFKRTHMEQAWVEHATTKKRKAFWFKKGEVQVSYPYSLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1K9</accession>
    <name>A0A7D5Z1K9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 6">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">agl2</name>
        <name evidence="12" type="ORF">G6M90_00g048190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544934.1">
        <property type="nucleotide sequence ID" value="XM_014689448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1K9"/>
    <dbReference type="GeneID" id="26242275"/>
    <dbReference type="KEGG" id="mbrn:26242275"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000028">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000118">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="entry name" value="alpha-galactosidase from lactobacil brevis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF3">
        <property type="entry name" value="ALPHA-GALACTOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02065">
        <property type="entry name" value="Melibiase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028919591" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 N-terminal" evidence="11">
        <location>
            <begin position="88"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 36 C-terminal" evidence="10">
        <location>
            <begin position="670"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="504"/>
            <end position="508"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="747" mass="82247" checksum="8AADADFF133ADB86" modified="2021-02-10" version="1">MGQVPALCRLTVFLLAAGMVSAASAQGGSQKPIQVDGTAFALNGDDVSYRFHVENATGDLIGDHFGGPAEGDTIEAEIGPVQGWVDMIGRVRRELPDLGRGDFRTPAVQIRQSEGHTISDFRYQGHTVLEGKPALNGLPSTFGKDDDVSTLVVHMYDNYSSVAADLSYSVFPKYDAIVRSVNITNRGKGNITIERLASFSVDLPWGDYDMLGLKGDWAREGMRVRRKVDFGIQGFGSATGYSSHLHNPFLSLVSRATTESHGEAYGFSLVYTGSFAAEIEKSSQGLTRAMLGLNPSQLAWPLGPGESLQSPECVAIFSSTGIGGMSRKLHSLYRQHLMKSKYATETRPVLLNSWEGLGFNYNASTIYRLAQQSAELGAKLFVLDDGWFGVKHPRITDNAGLGDWEVNPKRFPDGLEALVDKVTALPVGNSSTKLKFGLWFEPEMVNPDSNLYEVHPDWALHAGRYPRSLTRNQLVLNVALPEVQDFIVDSVSNILNSSNIAYVKWDNNRGIHETPAPYTDHQYMLGLYKVFARLTERFPDVIWEGCASGGGRFDPGVLQYFPQIWTSDDTDAVERIYIQFGTSLVYPPSAMGAHVSATPNSQSGRNETIEFRAHVAMMGGSFGLELDPSHMPEQDKAKVPDLIKLAEKVNPIVVKGDLWRLSLPEESDYPAALFISEDQKQAVLFYFQLKPTINNSWPVVRLQGLDAKAMYKVDGIQTVSGATLMNRGVSYNFEAGYSSKVVFFEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z251</accession>
    <name>A0A7D5Z251_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino-acid permease inda1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">inda1_2</name>
        <name evidence="10" type="ORF">G6M90_00g074840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986970.1">
        <property type="nucleotide sequence ID" value="XM_066131016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z251"/>
    <dbReference type="GeneID" id="90967955"/>
    <dbReference type="KEGG" id="mbrn:90967955"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="76"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="580" mass="63806" checksum="ADD0ACAE3DA1E1F1" modified="2021-02-10" version="1">MSDKHKEMDAVPFSDAEKGPAHAPIEGTSQIVSKDAIICEPHPDFMTRNGLNAESFKKQHYGWGIVELERPMKARHLNMIAIGGSIGAGFFVGSGGALANGGPGSLFIDFLIIGVMMFNVVHALGELAIMYPVSGSFYTYSARFIDPSWGFAMGWNYVLQWASVLPLELTVCGISIQYWNADISVGVWIAVFLVVIVIINVFGALGYAEEEFWASLFKLCAIIIFMIIALVLVCGGGPSDGRYNEYWGARYWYNPGAFKNGFKGFCSVFVTAAFSFSGTELVGLAAAESHNPVKTMPTAIKQVFWRITLFYILGLFFVGLLIEDTDPALLNAGAYNDPKASPFVLVGKYAGLTGFDHFMNLVILVSVMSISVSAVYGGSRTLTALAQQKYAPKIFTYIDKSGRPLFSVILIILFGFIAFVSLSATGPVVFTWLLSISGLATLFTWGSVCVAHIRFRKAWAYHGHTVDEIPFRAAGGVYGSWLGLFLCVIVLMAQFYSAITAPPGESGMATAETFFQQYLAAPVILFFWAVGYLWKREGWLRTSQIDVDTGRRELDWDDINAYRAKVAALPAWRRLIHKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2D9</accession>
    <name>A0A7D5Z2D9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g009230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985878.1">
        <property type="nucleotide sequence ID" value="XM_066129664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2D9"/>
    <dbReference type="GeneID" id="90967438"/>
    <dbReference type="KEGG" id="mbrn:90967438"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9863" checksum="F45CB2BF4E4EFEA9" modified="2021-02-10" version="1">MTSVHQKLIHRGGKVGDLNPKATFSFKTERKFKGPKGVNSQMIQDLHEEIPQQKLAGIAEGLMVRLYRIPETTEGSTELWYAEAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4U0</accession>
    <name>A0A7D5Z4U0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g032140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986256.1">
        <property type="nucleotide sequence ID" value="XM_066130100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4U0"/>
    <dbReference type="GeneID" id="26243950"/>
    <dbReference type="KEGG" id="mbrn:26243950"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="403"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="2">
        <location>
            <begin position="638"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1115" mass="124899" checksum="14701829200D8874" modified="2021-02-10" version="1">MATSASLAAACHLQILTNPRDNSQDGVDIVLVPGIGTTSPENWPFANQEWLASLPGSGAGARILTFQYASPFVGTMPSWESLLMTGYDLLQKLGDTRSQSDSDLTAKPIIIVCHSLGGIIVKQALCVANKQFNRYGSIVNAIAGVIFLSTPHRYGDKTTCFIRFRDILETTTGKNLKIPNENIEQEGAILLDLADRFEGISFRTPILSVYELRESKNSSTPLRPKYQLVNREACSTYAPMETVIGLNLNHNDTCIFTKSVGGEGLPKFNRFVYETLIDAVRLVALRLEDQEYQYATMSAYSPTMSELPLQVEQLELTEWPSNKATDWPSNRATEGTSLSGFELVYPTKPNTEIRRFLHLPCFLLNTQSANQDFCGREDILERLAGELLPSKDIVTGSSTALRQFALCGFGGIGKTEIAREFSRRHRASFDAVFWVVADEIAKLDQQYQQISLTLGLEDPSECKSQVVSREIVKGWLSNSRKHLLASDDIVQPGQASSEATWLLIFDNADDPMILADYWPQGTGSILITSRDPLAKSIFTRRPSGLDLGPLSQQDSMTLFSQLTNIFNEPEDNTARQISDALGGVPLAISQMAGIIRRQDLTLSEFLELYADHEEHANLYETKFDTNLVTYRHSLSTVWALEKLKPQARQLLELVSFLDPDVIGEDLLMEVSANLFSEGAQFKKSSYIEARADLLQSSLVQRDKTKQQLTVHRIVQDAVIATMDATKKRLIFDQVVRMLWANWPAAMPKPSKEPELPLPKSTGGRLHVARWPPCAAIYPHILRTHQLWSAITNVPEATSLLFAKLLNEAAWYQKERGRTKQFDGFFETAHSICDASTHADRDSLLADIHFCLGAIAMDASDFDASRIHKERSLDLVSKICRELGVADERLYLAYAERGISRIQDRRYEEGEADLKEALQIRKCLGNYIPRSGEVNLSWALLAQGKFEECSTLLLDSLAGREKALGKEDRESVRTGLIFYALGNLGAAQNQWDESFDYHQRAWRHMRATVGDRDFYTANVAHKIAEHFLRLGRSEEAIAMINEALDIWSVDPSAHKNEIARTTFMKGKLFEATGKTQKASIALRVACRLRKEITKDDRDVTSLTMCDFDELVAFWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Y7</accession>
    <name>A0A7D5Z4Y7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl402</name>
        <name evidence="6" type="ORF">G6M90_00g107930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544051.1">
        <property type="nucleotide sequence ID" value="XM_014688565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4Y7"/>
    <dbReference type="GeneID" id="26243438"/>
    <dbReference type="KEGG" id="mbrn:26243438"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="281"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="37787" checksum="126805D50DD63751" modified="2021-02-10" version="1">MASRPTVSIIGKDGAPTGATHPVPAVFTSPIRPDIVQRVHTGMAKNKRQPYAVSEKAGHQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNMCRSGRMFAPTKIWRKWHVKINQGQKRYATCSALAASAAAPLLMARGHEIMTVAEVPLVIDSAVFDSAAVSRTAPALALLKAVGAGPDLEKAKNSKKLRAGKGKLRGRRHRQRRGPLVVYNPEVDGKELVKAFRNIPGVETSPVSALNLLQLAPGGHLGRFIVWTSSAFKALDDIYGSTTEASAHKRDFFLPSNVVSQADLTRLINSSEIQSSLNAPKGEAVTRRSAVQKKNPLRNKQVMLRLNPYASVFAKESQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z572</accession>
    <name>A0A7D5Z572_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g059450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986765.1">
        <property type="nucleotide sequence ID" value="XM_066130680.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90967826"/>
    <dbReference type="KEGG" id="mbrn:90967826"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="39" mass="4056" checksum="D1E7554D786BFA4B" modified="2021-02-10" version="1">MFLAVAATVAASQSQQHLGHGSGPLDFADSFIEYDASDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5H8</accession>
    <name>A0A7D5Z5H8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987935.1">
        <property type="nucleotide sequence ID" value="XM_066131849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5H8"/>
    <dbReference type="GeneID" id="90968267"/>
    <dbReference type="KEGG" id="mbrn:90968267"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028922702" evidence="1">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="204" mass="22576" checksum="C2AA8F6114371699" modified="2021-02-10" version="1">MQHAIIIWLAAFTSATVLAVPLDTVQEIQNECCAGFSLGEAPVCPEDEDFPEDGICWGNQPKRIPRPPGRDPAVLGQKWLQMVNAFADKREITPEAKQGLLDIIPSCELNAGAHPGGANAGVRCTVDSEEQRPTPSCDDHRSDTTVLGRNWLQLFHKVKGGWKQKWVDSISRCQIKVPTILPNTVLRLEDIKEVWCPLNPTSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5X8</accession>
    <name>A0A7D5Z5X8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypacidin cluster transcriptional coactivator tpcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpcD</name>
        <name evidence="1" type="ORF">G6M90_00g052530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540381.1">
        <property type="nucleotide sequence ID" value="XM_014684895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5X8"/>
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    <dbReference type="KEGG" id="mbrn:26246743"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF15">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTIONAL COACTIVATOR MDPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="461" mass="50398" checksum="30469029211FE37A" modified="2021-02-10" version="1">MDSIANLVSCAAATTADVEALVAMCRVQCPSEADESIKIHAILQDGPAELQRLKKSMMANVTNLQQLIMEPSELLQQLACQTAQVLRTSTKECLIKSQLLACLHWLGDFQVLACIPLRHSVPIKDISDLAGVPEAQLCRIARMTMAFGFLCEPQPGRLSHNALSAAFVTNPSLLDAVMFLAGTATPSALKMAVNTQRLNYSSTPQATAYNLASNHASSFSAECEQRPQLRRQWSAFRRYGTGDVDDDLVEILQSLQCANQFVGKPCTVVEIGAESTTQAMALASHYPCLKIIVQMGDLEAQWQNSGGKNISYESMLDQPGCIVDGRVTTQRRPMGTTQTIRDARVYILHLTSCTGVTEGVQAELKQLVEVLKNNKPGRIVLTSGLLPELGTIRRSVEALARLRDLTMFQLANQRELEMAEMMGILNSMGDNTGRLIVENKYCSPTSGASALEIRYHEYVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6J7</accession>
    <name>A0A7D5Z6J7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g031120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986468.1">
        <property type="nucleotide sequence ID" value="XM_066130080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6J7"/>
    <dbReference type="GeneID" id="90967585"/>
    <dbReference type="KEGG" id="mbrn:90967585"/>
    <dbReference type="OrthoDB" id="3518210at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="155" mass="17187" checksum="3F88FC821FCCB486" modified="2021-02-10" version="1">MSAQSLTGSQVPCSNEQPARQSDNAQVDDTRATQTWTQSGYPIVDGKYLDGNGVTQSIGDEWTMSGPPVIDVYWHNRRRSRQGTRAYFGSIGANAFDDLTEYISRVREFLRAQGHVCQIMSLNATAYSVNVIVASELSTDEMGDLLWDYRLAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7W1</accession>
    <name>A0A7D5Z7W1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g111950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540267.1">
        <property type="nucleotide sequence ID" value="XM_014684781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7W1"/>
    <dbReference type="GeneID" id="26246861"/>
    <dbReference type="KEGG" id="mbrn:26246861"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028997681" description="Epoxide hydrolase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="6">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="47547" checksum="FBBC989855F01E3E" modified="2021-02-10" version="1">MLHHIALALAFSSHVNAYNDFHFGFNFHDIGYAPQGVNISVDPRIVRKTLQRVRDYRPVTGLFDDWTVEGPSKDNITSVAKYWADEYSWEDTQEQINRDYKHYITKVPGSGNYTSDIPLHFLHHESENDSAIPLLLLHGWPSTSLEWSKVIRPLAESSELPFHVVAPDLPGFGFSPAATQDGLGTREIGRAVDALMKQLGYSTYGLATTDTGWFIGMWMVHDVADSIIGHLFDFWYPNPNSTDMERFQANQTTAEETAVVESLHVWDDFHNAYSMVHSQKPIAMSLALADSPVGFLGWYWDLSYAISDGIPHSMDELITDALMLWLPGPYGNIRSYRQIFRPDIVDFPKTNVPSGVSQWGWGHGPFPGIANFPFTPRNWIERLCNVTYFKTHKRGGHFPARTLPEYWVSDVREFFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8T7</accession>
    <name>A0A7D5Z8T7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g071880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545872.1">
        <property type="nucleotide sequence ID" value="XM_014690386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8T7"/>
    <dbReference type="GeneID" id="26241905"/>
    <dbReference type="KEGG" id="mbrn:26241905"/>
    <dbReference type="OrthoDB" id="5399559at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="3">
        <location>
            <begin position="159"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="428" mass="46019" checksum="37EB86E08A384C60" modified="2021-02-10" version="1">MPAAATQPAPRGSKKKTTGAAKRAESPASSIGSRAAADLLDEDFESSDIMKLQKSIRNLNKKITNASKTDALLSQEQHAGKTLEQLVNEKTINPDQRAQIEKKPELQAQLAQAEEQLAQLRKVHEQYRSRAANEKAEWEKTLEKAKADAVSEAEASFQNSLKGNLLLLSQFLRLAAYRREEATDAESDESQAIEGVLLAIYAGDDSAVASMLKLVEGTEDKVLSVPGEQLQTTYSVVKTLAQEYKAPVYSEVPAEGETAEVVTGPTVANVAAIEVADTDVSASPGEKKAEASNGHPSANISNTAANAVAESHWDTEAGLSTSQEWVDVKASRDITEADTGLTDTPASSGNTQSWADEQPEPTKPSDGNDGFHQVQRNKGRHEREGNGNLRGRGGHRGEHRGRGGHRGEGRGRGRGRGISSRPRRNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8U0</accession>
    <name>A0A7D5Z8U0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540435.1">
        <property type="nucleotide sequence ID" value="XM_014684949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8U0"/>
    <dbReference type="GeneID" id="26246797"/>
    <dbReference type="KEGG" id="mbrn:26246797"/>
    <dbReference type="OrthoDB" id="193478at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="31800" checksum="D2C01C3ED8BA9580" modified="2021-02-10" version="1">MASTRSRPKVSLLLAVPLSTVLFLFALFAFTGVPRFRADPSLGVFSLFRTLETGTNIIDHRKETAPRWLYHGLHAGPAMVWCVAMPLQHIDGLRMKWPIFHRINGYTALTVSLIQSVSGVLFLIYGYAYTHQNLLHIHYLYIRGKWIPPFFWPTFEAGLWVYAPIFVFTLVRTVQTARSRNLAQHRKWAVLHTIAGYVIAINRLNLTVLLALGDILTWLPVRTREFVLGSPSFTEVVDMEISAFAGAAAYAYVIAGIWAVTQVTNRGRTPSRKAVLEKATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8Y9</accession>
    <name>A0A7D5Z8Y9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FUMR</name>
        <name evidence="7" type="ORF">G6M90_00g091030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541757.1">
        <property type="nucleotide sequence ID" value="XM_014686271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8Y9"/>
    <dbReference type="GeneID" id="26245620"/>
    <dbReference type="KEGG" id="mbrn:26245620"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="78"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="477"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="536" mass="57565" checksum="B5A63D07B27AC372" modified="2021-02-10" version="1">MLRSTSSRALASGLAKSSVPRVGRAANAAASSASRGGAVAWTPQLQVQLNSRISSCRSIHSTARNMAQATRTESDAFGEIQVPADRYWGAQTERSLENFRINQPQDRMPPPVVKAFGILKGAAATVNMRYGLDPKIGQAIQQAAKEVADGKLMDHFPLVVWQTGSGTQSNMNANEVISNRAIEILGGEKGSKKPVHPNDHVNRSASSNDTFPTVMHIAAVLELENDLIPALRSLRKALQAKVDEFQAKNIIKIGRTHLQDATPLTLAQEFSGYVAQLDFGIKRVEGSIPDLRLLAQGGTAVGTGINTFQGFAEAIAEEVTKMTGTEFKTAPNKFEALAAHDAIVQAHGSLNTVATSLTKIAQDIRYLGSGPRCGLGELALPENEPGSSIMPGKVNPTQCEALTMVCAQVMGNNVATTIGGMNGQFELNVYKPLVIRNLLHSSRLLADGMRSFEKNLVAGLQANEDKISQIMKESLMLVTCLNPKIGYDMASKVAKNAHKKGLTLKQSAMELKALTEDEFDALVKPELMIGPSPYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9A3</accession>
    <name>A0A7D5Z9A3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">skb1</name>
        <name evidence="12" type="ORF">G6M90_00g071630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545896.1">
        <property type="nucleotide sequence ID" value="XM_014690410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9A3"/>
    <dbReference type="GeneID" id="26241929"/>
    <dbReference type="KEGG" id="mbrn:26241929"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="37"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="380"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="559"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="411"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="781" mass="86302" checksum="B9EB7C3015E1507A" modified="2021-02-10" version="1">MSDSFGAQAPPFHIGKHDSKRAVPLTDLQYGYLLNQGINFATTPVTNDHFRSRVFKIVSDHLKLLAENNEESTSTVTGSRADPIIPPLTPDDTGLFPSPTVNTYTAYISPWIDLCSSNPLIASISRQVLNLEINYANFCGVRSIIIAGPSRDASQTGGNQALAQYSRAVQEALTIGSALTILVHMPMYQEPTTGQETETLSSLEERTPASPGSKEIDLFAAWASWHHVRSICNYNLRLFVALQVPRMMPEKDLQTRWFAEPLHYLTIGSEVFQKNKSGFPSLSKHHQEMIFSYMKLKASPWILLCDVGPDASKFKANDPSILSVANRPEMTEDDFPSLADAAGMSTNQTSRPGVDAHMAYLQWLESQQPPLTALESPTLTSFQDWLQSPLQPLSDNLESATYEVFEGDPVKYDQYEAAVIEALSEWKELDLPTSKEGVVVIAVAGSGRGPLVTRALKAAEYTGVKVEVWAVEKNPNAYVYLLRQNHMLWGGKVNVIKTDMRAWKGPVVSQSSGGPVYGKVDILISELLGSFGDNELSPECLDGIQHVLAKPHGISIPHSYTAHMSPISTPKVYGDILARSATEPTAFNTPWVVRLYALDFVCQRVPGHARFQQAWEFSHPIPESTLTNIDARRSGGIMGGGGGSMAGAAGANDHNSRYCHVTFVCRSQGVTHGLAGYFESTLYESRLESQKGEKVEISTHPERIDQKSKDMISWFPIFFPLKEPISFPADTELEVSMWRQTDDTKVWYEWLVEAWTWVGESSRIKVGSSGLCSSRKVACLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9V4</accession>
    <name>A0A7D5Z9V4_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g094830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="DUF7053"/>
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        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
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            <begin position="195"/>
            <end position="238"/>
        </location>
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            <begin position="283"/>
            <end position="366"/>
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            <begin position="212"/>
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            <begin position="283"/>
            <end position="293"/>
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        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
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            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI73447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="366" mass="40414" checksum="FF081C133A565B74" modified="2021-02-10" version="1">MSNMLRKKDVFTVITPIPGFIPRQLALDILHSHSEVITLNPLVLEHKPISAPRNAAADEFYSTWYEITQRIQFVPGVGNLGSGKITFTGCFHDMPWGLQTHVYAPFNVDMRSKYQIGGNQPGLEPPEQRELGLGAPADGLYLREDIEIKCNIAMVSFVKSQAKAANKAMVQRIVKKAELLDAGVLKAMMEDGKLKTINPNDRSRLDRTSTVSYSHSSGMPSSPGAFQQPQPLPYQLPASPSYHAQQMYQAQGQPAPYNYDKYLPPVPSAPVELPADIQQYQYYHSQPQSRSPQLQEFTPNYRQSASSSDPRWSLGQPSPSLADTHRTSASSVLSGAGSFGHPSPGLQRTAFAPELAAHTESRDEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBV7</accession>
    <name>A0A7D5ZBV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112580</name>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="143"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="289" mass="33035" checksum="D1BEAA7319DC14E8" modified="2021-02-10" version="1">MTAIEKAVREAFDSDTLADVKIYLGDVELPAHSLVLTAQSSYFKRALLGEMQEGKTRKFEYSEGSMHAYWRVFEYMYKGTYSEEPCMKLTELDDDELSKEVRVYQLADYFEVDGLQREALRRFTTKTIALWATEAPLKSGEFSDLTFLCEGQRIPAHRLIVCPQSPVIRAACTGSYKEKETGVYEIKDVSFDVVRQMVEYLYTGRYQVPSSQDSDDKKQYAVLPLVFHARMVDVADTYIIKGLQSLSMANFKKSARRDPDDCVFLRAIVDIYSLQCGPSQVLRDIVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCF1</accession>
    <name>A0A7D5ZCF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540777.2">
        <property type="nucleotide sequence ID" value="XM_014685291.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCF1"/>
    <dbReference type="GeneID" id="26246390"/>
    <dbReference type="KEGG" id="mbrn:26246390"/>
    <dbReference type="OrthoDB" id="5365129at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38302" checksum="C4F3DD167CF4343A" modified="2021-02-10" version="1">MAFVWSVVGMGSLVSMMVGGGFSIGAALMGAISLTVPRPLIFDPTNIIYSFKLGLDGAGANEGYDLLRGAGGRAPKIVVFDNHGTQIGQTKKQAKCGDGEDHCVEVVKKIKKQPAYAMLLGQDNPICLAAASVTYPSGDRYAWVGNWAHTCNKAWYFSDIDAHHTNGSVKLLCAWLGFDGYKNNYSTGIRIHFPEFAKGFAGNGNNATYYCQHNNTALAFFNNRGPKYFNGDNEQEHRVNEKDKKEQDKKNKGKRSADMKTQSVRSYRAAHSAKVLCDSSSSAGPSLVSVHERSFCHMPDKVLYHFCEDVSVGSCWDHKAHAFGAKGPRAMQARAALPDVEFDKPTVWGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPQ5</accession>
    <name>A0A7D5UPQ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tom7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g004500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985606.1">
        <property type="nucleotide sequence ID" value="XM_066129571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPQ5"/>
    <dbReference type="GeneID" id="90967416"/>
    <dbReference type="KEGG" id="mbrn:90967416"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6063" checksum="C272823B0274010D" modified="2021-02-10" version="1">MFALSEESKERIAKLIDVSRVAIHYGYLPLILYLGYTRSDPRPSIIRLLSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPV3</accession>
    <name>A0A7D5UPV3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g010940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549427.1">
        <property type="nucleotide sequence ID" value="XM_014693941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPV3"/>
    <dbReference type="GeneID" id="26238871"/>
    <dbReference type="KEGG" id="mbrn:26238871"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI63719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="570" mass="64120" checksum="ED03E01BB275F7DA" modified="2021-02-10" version="1">MLSLQGRLPARRYIALAVFFLLAIILWQGFNPSRLPFKAPGGSSIPYVPSTIDWSQAKIYFPPNKTVPLPSGRPKTLPRVQARAASEDSHDASKSRREAVRKAFIKSWNAYKQYAWGKDELMPLSGKGKTTFSGWSAQLVDALDSLWILGLKDDFRHAVREVAKINWSKTDGSNINVFEVTIRYLGGLLSAYDLSGEEVLLKKAVELGDALYMAFDTPNRLPTHWLSYTKAENGETLGDTSISGAASGSLCVEFTRLSQITGDAKYYDATERVKQFFYENQNHTKAPGLWPWDMNFREGTIKDGFFTFGAGADSQYEYLPKMHALLGGLDPEYVEMTILSLDAGRDKLLFKPMTPKDEDILMSGNLDTFTGKRESTAQMQHLTCFVGGMYALAGKLVGRNDYVDLAARLTAGCVWGYDSFPTNIMPEGTELVKCENMDQPCPYEQDRFSAGSSKNLPGGFLRINDGRYMLRPEGIESVFYMWRVTGDPVWRDAAWRMWEGIVKETETELAFASIQDASRHGSAKLDSMETFWLAETTKYFFLTFEDEDVISLDEWVFNTEAHPMRRPIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ80</accession>
    <name>A0A7D5UQ80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g022250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985680.1">
        <property type="nucleotide sequence ID" value="XM_066129890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ80"/>
    <dbReference type="GeneID" id="26237773"/>
    <dbReference type="KEGG" id="mbrn:26237773"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="971" mass="109221" checksum="86324EC11DC6469F" modified="2021-02-10" version="1">MASNGTQETFSPSDVLAAVRTMRTGEKETKTKAHEYLERFQKSKDSWGTIMGILQSTAEPEATLFAAITLRGKITYDLTTQVPPSELPALRGQILLLLKHFAAGPKPIRVQLCVCLAILAIQMKDWNDVLPSVVQSLGDSPESHACILDFLRVLPEEVTEGRKITLSEEELAARTQVLLGDNIDQVVQLLISYSQSSPAAPRNPQLIECITSWLREVPVMNIINSPLLDHIFAGVSSDESGAEAAECLCTMLRETRDIDESQDAVHALYPRVVALKPQIEKAAEADDTDQLKALTKVFSTAAISWVVGIAREPSHFRPLVEAVLECAARDKERDVIEHTFDFWYELKQYLVLERYIQGRLELVDIFSKLVDILLRHLEYPRPESGNESDLFDGDREQEEKFREFRHRMGDTLKDSCDVMGVTECLTKVLHAIKLWTQKYAGQVNGSDVPHWQELEAPLFAMRALGRMVHKDESIVLPQLMPLLVQIPSHEKLRFATIMVLGRYTEWTAAHPEYLEPQFNYIVESFQTESREILRAAALSLKFFCTDCRNLLSGQVLQLQTFYDQILDKLPDLSKEEITEGVANVVAVQPVDETYRLLKTYADPLVQRLMAKANNASNEEGKLALADHLQLITIFVQNVVPYVAPGGENPAVKYWQEIFPILSTVLDNFLDFSPICERICRCWRNMVTSYRTAMAPLLPEMANKLASSFNTSREGCFLWVTSAILREFSEDREHLDQATTENIYTFFEAQTTAFLRVMADLQPKDLPDVIDDFFRLLIDALLYYPQKLIPSQLLVPIFQASVYALTLEQRDPLSSTLHFLRDLLSYGGDNPASSEGLPEAQAAEIRGIIKNLLMAHGADLVKQTMAGMMITFPGDCFADGSGVVLALFEIMPAQTTEWVAHTIELLPQGTVSAPEAQRFVTKIKEKLSSGDVSGLRHVRTLLQDFTTNYRRRNVAPRDGLGQLEAARFQFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQC8</accession>
    <name>A0A7D5UQC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g008690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549641.1">
        <property type="nucleotide sequence ID" value="XM_014694155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQC8"/>
    <dbReference type="GeneID" id="26239085"/>
    <dbReference type="KEGG" id="mbrn:26239085"/>
    <dbReference type="OrthoDB" id="5424797at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="361" mass="40334" checksum="9584543B46B76E2F" modified="2021-02-10" version="1">MDDRNSALHVSLQPKKPPIWTKYGERFGVSNSSNSLPSRQATIEHYWSREATRVAAQNEQDAASTGHSPSLGPRIAVLLPVSPSPSKAYPGPKQEPENEAPLPNQLELPKRVKKNVGLLSQSPGQDTAQSSATPPPSSTSTPSSYSRGRPKGWKRGMSYAAMRGNTPPTWKTVRSPRQSRTKAPQPGFGRRPGRPPRPRSPPPKDLYHKANPHFVNFLCEWDGCKAELHNFDTLRRHLHIVHQQNGKWPCKWAHCGLDACADARQWRSHLEDAHLTPFRWHVGDGPSNSSGMRAVLPDDAQDELPDFLMGSDGQQVTPSVKNQQIEDFATWRENRRKLKELLIQRDQNLPDESSESSGETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR47</accession>
    <name>A0A7D5UR47_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g004020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542054.1">
        <property type="nucleotide sequence ID" value="XM_014686568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR47"/>
    <dbReference type="GeneID" id="26245085"/>
    <dbReference type="KEGG" id="mbrn:26245085"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028901216" evidence="2">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="79" mass="7734" checksum="4807A55278B98705" modified="2021-02-10" version="1">MKLTAVLVIASAISVHCQASNSTSRTSTITAPPTARPTTSVGTTSRTTSRTSTTVVAAGPNPVAPGLGLAALMALGALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US01</accession>
    <name>A0A7D5US01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SecL</name>
        <name evidence="6" type="ORF">G6M90_00g020330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548512.1">
        <property type="nucleotide sequence ID" value="XM_014693026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US01"/>
    <dbReference type="GeneID" id="26237956"/>
    <dbReference type="KEGG" id="mbrn:26237956"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029039333" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="40"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="577" mass="61871" checksum="2784E0379F9C5BE9" modified="2021-02-10" version="1">MKPPAVLLLAASPVLAGAGAGPVVHDADKDVTYHGLCRNGIDVFLNIPYGQDTSGENRFRPPRPHSSRRGSAIDATAYGPACPQALGPWVPPISLTNMTKVSEDCLNLNIARPAGESVGGEKLPVMVYIHGGSFWAGSNEEITIRPDGMILESVKNGLPVIHVAMNYRLGFFGFARSDALRKEGSENAGLKDQRLALEWVQDNIAQFGGDPNRVTIFGQSSGGLSIGMHIMAYGGSKPAPFQQAIAESQALEPGITGNFTTNAMQALVDHVGCNKTPLGSASTIACLRSFPTDTVLNASLATYQSDTAHNIGDIWLPSVDGDFLPAPPSQLIREHRFASVTAMMGWCDDDTTFFTDANITTASDTHAFLRAYAPAVSPANIRRLEALYPASDFPADAAANASSEFYRSARIFRDIVMACQPLGYAEQLAAAGNPVYLYDWNQTVLDAFLTQVARRPGMGPIHTSEFAYIFGNLSHYDTGDYDFRPSPADYALRDRGSRSWSTFASTGRPGLEGHDTLQGFAPAFTPDGRVNVFVVGGPSEGLSPIDGPGANSALERQKLRARCAFINSPEMIEQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US74</accession>
    <name>A0A7D5US74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">his3_0</name>
        <name evidence="13" type="ORF">G6M90_00g024620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548120.1">
        <property type="nucleotide sequence ID" value="XM_014692634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US74"/>
    <dbReference type="GeneID" id="26237564"/>
    <dbReference type="KEGG" id="mbrn:26237564"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="34"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="404" mass="43625" checksum="E6CE41F20A18F8A2" modified="2021-02-10" version="1">MPPFNLETCARPNILALQPYRCARDDYKDDGTNVLLDANENAYGPSLDPAAVEHARSSLGGLDPLGLHRYPDPHQPELKQLLCRLRNTHAHTPKAIGPENLFVGVGSDEAIDALLRCFCVPGKDRILTCPPTYGMYAVSAQVNDVDLVKVPLTPAPEFALDVPAVTAALSSEPGIKLAYFCSPGNPTGSLLAKEHVVQVLNHPTWNGVVILDEAYIDFAPRDSSLAELVAEYPNLVVMQTLSKAFGMAGIRLGAAFTSPPIARMLNSMKAPYNIASPTSALAQSALGDRGLAVMRANRAKIVAQRERLIQELPKIEGVGRQRGGTASNFLLYEILNTLGKPDNSTAVAVYEKLAEHKGVVVRFRGKEHDCLGCLRITVGTEDEVTKFLDSLRNALIEVRGVSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USE4</accession>
    <name>A0A7D5USE4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arabinoxylan arabinofuranohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xynD_0</name>
        <name evidence="9" type="ORF">G6M90_00g002350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542845.1">
        <property type="nucleotide sequence ID" value="XM_014687359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USE4"/>
    <dbReference type="GeneID" id="26244218"/>
    <dbReference type="KEGG" id="mbrn:26244218"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18827">
        <property type="entry name" value="GH43_XlnD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="AL/BT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052176">
        <property type="entry name" value="Glycosyl_Hydrlase_43_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43772:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="3keto-disac_hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028891987" evidence="7">
        <location>
            <begin position="16"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="3-keto-alpha-glucoside-1,2-lyase/3-keto-2-hydroxy-glucal hydratase" evidence="8">
        <location>
            <begin position="320"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="486" mass="52993" checksum="A3B3CC6851A3EDF3" modified="2021-02-10" version="1">MKSSLLLAMIPAAIAHTPDFKTSEAGNPFVDGFYADPDNEFYNNQYWVYPTSSYEYDKQTYLDAFSSPDLVQWTKHANILVASDFTWARRAVWAPAPISRNGKYYLYFGANDIQTNSELGGIGVGISDQPEGPYKDALGKPLIGQYYNGAQPIDQDVFIDDDGQAYIYYGGHGHANVAKLNEDMVTIGTFDDGTSYREITPENYVEGPQMMKRNGTYYLFWSEGGWGGPDYAVSYAMSTSPTGPFKRLEKILQQDPAVASGSGHNGVIHVPNTDIYYIVYHRHPLGENIDANDRHLAYDRLYFNADGTIQPVRMLVHDNFNDGNMIGWTTYGGSWDAKTNALRAGASAGGKALLNTNFGDVDFSADVKMPSANGGDAGLVFRASTPALGTDAYDGYYAGIGTSGKLVLGRAEGGSWTQLASVKADVVPGKTYRVRVTAKKNAISVYAGDSTSAQLHVLEGTFGSGMTGVRVYQTDAVFDNVRVEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USP9</accession>
    <name>A0A7D5USP9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g012040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549318.1">
        <property type="nucleotide sequence ID" value="XM_014693832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USP9"/>
    <dbReference type="GeneID" id="26238762"/>
    <dbReference type="KEGG" id="mbrn:26238762"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="43925" checksum="A88A05C8CF00A3BF" modified="2021-02-10" version="1">MASSTTPRRRRYKDTPSTPVSRSEAEELPSSEKKRLDGVWQDGLWWCNCDPRKKAVLREVKKECPNKGRLFWTCETHRRLSCNFFLWRDDAVVRESSFAPGSDADVVDDRAVPARPKTPTFTQRPLESYGIQATPSSRRSGILGGVNKTSKAADSSPTSTRRTRETQALAPKASPATPSSKRKRNPNDSWDQDEDEFTDLDSDAERQLAEITDKSVQMATRRRSSDDVFATPSTNRRTTVIVGGLPTPSVSRTLFPASEAKRSKAVSFEEPTSSGTLKTPSKTLSSDSNFSLVSPSSSPHGASTQDVTENVMALLSRQKIDPAVLQSVQELLLMSARKTKGVSKGRDSARAALKGKDKKISQLQEKIRDLENQAAYNHKRMTDMKAQLIRLYEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USR9</accession>
    <name>A0A7D5USR9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g020530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548493.1">
        <property type="nucleotide sequence ID" value="XM_014693007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USR9"/>
    <dbReference type="GeneID" id="26237937"/>
    <dbReference type="KEGG" id="mbrn:26237937"/>
    <dbReference type="OrthoDB" id="4398476at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="185" mass="21483" checksum="0CC82E967F567A4B" modified="2021-02-10" version="1">MSNNDTPVAFVKKWILQQTRLVLPPTWNGGWERWAQGQIAILMEGQDGYQVWTEQNIYLDHPNYAVDLEFRKPPGVRGVRKFLELKCYSEVNEDTAYRFITRVLEDFDKVTKLRLTRGVPNEPDAKGSTLWVIGISQKQFRDDITRAGLGEVNWLRFRREEAVSSGGSGDRGTFDIWYYSFVNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT24</accession>
    <name>A0A7D5UT24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PRE6</name>
        <name evidence="7" type="ORF">G6M90_00g014800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549044.1">
        <property type="nucleotide sequence ID" value="XM_014693558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT24"/>
    <dbReference type="GeneID" id="26238488"/>
    <dbReference type="KEGG" id="mbrn:26238488"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="269" mass="29209" checksum="3F727B2AEDB1A562" modified="2021-02-10" version="1">MASGYDRALSVFSPDGHVFQVEYAGEAVKRGTCAVGVKGKDVVVLGCEKRSAMKLQDTRITPSKIQLLDTHTALAFAGLNADARILVDKARLEAQSHRLSVEDPVTIDYITKYVAGVQQRYTQAGGVRPFGISTLVVGFDPGSKVPRLYQTEPSGIYSAWKANAIGRSSKTVREFLERNYKDDMDREATIRLAIKSLLEVVQTGAKNIEIALMAPGATMEILPTDEIEGYVKEIEQEKQEEAAKKKTGRTPGTGSAAILTRGQDDSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT34</accession>
    <name>A0A7D5UT34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g022420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548312.1">
        <property type="nucleotide sequence ID" value="XM_014692826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT34"/>
    <dbReference type="GeneID" id="26237756"/>
    <dbReference type="KEGG" id="mbrn:26237756"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 SIN3 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="179" mass="19606" checksum="E7643651B4A44520" modified="2021-02-10" version="1">MPPPKSSRTAADDHKTDTTGGPKEKGSGPASAKMRRGASQSSASQLREAHAANTPTSAPLQSASEAQAPTINWSSFERDALHTYRREHQLNTPASFASKYHQLLLSRSGSIGLYSPTMTRKQQTRRQSKDNLAKAVRKHFNGLGIQENDVVVDFIYKIRNEKMARAGGPNRQPGIISEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTE5</accession>
    <name>A0A7D5UTE5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetraspanin Tsp3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g033680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543295.1">
        <property type="nucleotide sequence ID" value="XM_014687809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTE5"/>
    <dbReference type="GeneID" id="26244096"/>
    <dbReference type="KEGG" id="mbrn:26244096"/>
    <dbReference type="OrthoDB" id="71600at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29699" checksum="876BA647AF7D110A" modified="2021-02-10" version="1">MFNPGIAYMLVCVVLFAIAVVIHYHTIHLSLPISSAITILSTILPITAFLNAYVYPNLLRSSHTFTSGDIFTRLAPIVLQGFQAIITAILATLLLEGVVPSPALEFLIDYEWDKLYQAKNADYIEYIQDTYSCCGLNSVDDRAYPFSNVPSGTCAEIHGRTRACRGPWTLALQAASGVDFGVVVIVGLMQVMGLLIMRERTAWWTALRTEDWKPFSETDDESSRRLATVAEESEESSEQGESAQRGGYGAIETPATGPSASHEEAQRPNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV28</accession>
    <name>A0A7D5UV28_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g035690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546964.1">
        <property type="nucleotide sequence ID" value="XM_014691478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV28"/>
    <dbReference type="GeneID" id="26239527"/>
    <dbReference type="KEGG" id="mbrn:26239527"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="179"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37680" checksum="5B6C00E5396CFA6C" modified="2021-02-10" version="1">MSKNAAWGPSQAQDEDDFIPPSLEQHTQVTRLSDQIFSADLSEELCIGSVPNGGYVGSVILRAAQEYLTPQGQPDTLKIHIQYLNRTAAGQAYLVVEEAKMGRNSSVLHISLHQHGLLESRPWLDPASRAKGEVVAYVTNTDLDKEQGLTLNTAWIMPYEPAPADLTRMREGSDPKWKRLHIPLMGRVSSIRTLEYYFQRAGHATPSTHDYWLRCANGEPFTNISLGFVADAAAALIPEAYRQRDGSQPPKEGEIAFDQAYWYPTVTMAIEVKKKLPAGGEEWLRMRASSKAISNGRSDMEIIVFDTSGDLVALSHHVCMAVDFARNIKERTRPQEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV73</accession>
    <name>A0A7D5UV73_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539734.1">
        <property type="nucleotide sequence ID" value="XM_014684248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV73"/>
    <dbReference type="GeneID" id="26247491"/>
    <dbReference type="KEGG" id="mbrn:26247491"/>
    <dbReference type="OrthoDB" id="5310497at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="35475" checksum="7A0362FE51577197" modified="2021-02-10" version="1">MRYSIVFAASLAARVSGHGLIRSIEGANGVSMPGLTVADGTPRDCTNNPCGSQADTAIIRDVQIKLGKCGPLGQTQGHGSVNASAVVANFMGTGGPAPVNKRPDGALGTIGVVPSEDNSFMTPEQRRQEYNRQAAELFKGESNDVVSPMTPYDGAGKSKPKNKKPPYGVGKAKGKGKAKGKAKGVNKKSSKIYRSETLNGDMRGQGAETGLPTCNDEGVINLIYHQINEDGAGPLDAAIDCTSGGSDASAFQPASVIRDIPGSAGISSITNTDHPVQVQMPAGMTCNGEVAGVKGVCIVRVRNTAGAGPFGGSAAFTQSQESRKRAIAYRLQKRMEIGSSKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV95</accession>
    <name>A0A7D5UV95_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Structural maintenance of chromosomes protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">smc6</name>
        <name evidence="15" type="ORF">G6M90_00g042650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547601.2">
        <property type="nucleotide sequence ID" value="XM_014692115.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV95"/>
    <dbReference type="GeneID" id="26240164"/>
    <dbReference type="KEGG" id="mbrn:26240164"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="129"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="317"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="454"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="753"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1169" mass="132122" checksum="6E61BEABA8964150" modified="2021-02-10" version="1">MAPLKRARIAVDSDDMSGDLDSTEGGSSLANDSQTTKRLRMSLEATHDSTPRTTTREDGSSSEEEEDDDDVDNGADIPNSPPQTQYEIMRDAGFKHLQNTDKDDFQATQKLRRRPTNVVQNMAAESGIIESITCYNFMCHERLHVELGPLINFIVGENGSGKSAVLTALTLCLGGKASDTNRGGSLKSFVKEGQDHGSLVVKIKNAGSDAYQPDIYGDSILVERHFSKSGSSGFKIKNEQGRIISTKKQEVDEISEWYALQMGNPLTVLSQDNARQFLNSATPAQKYKYFVSGVQLEQLDNDYKMSQDTLDRTIILRDDLSEKIAHVKKEMEDAQRLAETVQRNNTLRERARHYRNQLVWSQVVEREQELELQNAELETRKQKIIQLEKNCDELSRALDEITEKLERAEATRNGLNEEYRAIGESIASAEGIYTGAKKDLTELHLEERDAFARLKAVKADIETYETRIREEEAKLVASSGFARVEKEAEHKRAQAREAELNDQIEDCTQQLPSLQSKIAEIEHAVKRHQQLKEQKRKDIVAAEQGVRELEKSTGSIYDGFDRDIIQLVKAVAADSGFGSKPLGPLGAHIKLLKPEWSGILEKTLGDALNAFVVRSKRDQSRLSSLIRQSGMKRPPPVYIAYGGRIDTASQEPADEYDTILRVLEFDDELVRSQLIINHQIEKVILIKDRVQAEAVMIDSGPPRNVAACICFHDGKGKRGQGLRITNRAGTIGTAPTIPSGMRPRMQSDAARQLAMQKDNLKQLGLELRDLMAEEGQALQALQKAKQELEKHKKNMKALENDLRRTQADIEKAAEELDTFEGVDDRLDLLRSELSAKRTEETQLGNQYGSLKLSKRELGAKAEEAKKKLDAARDEQKDFQNRVSKSDTKIQSYNSMRRITVSKKNHEFEQVDMGRAALNRAESKRDEKAEQVQDFIRQAEEVAPGRVHIPDGEDHQSIEKKYEKIGEQLAQREARIGATDQEIYDRANEASIKYESVLRQTQDVDETIMLMKRAIEHRLHLWRQFQRQISARIRIQFNYLLSERGFRGKIDLDHRGRKVTIHIEPDETKKSSAGRNTKTLSGGEKSFSSICMLLSVWEAIGSPIRCLDEFDVFMDNVNRAISTNMLVDAARRSVSRQYILITPNAIEGRARLDKDVKIIRLTDPRQRTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVK7</accession>
    <name>A0A7D5UVK7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g039980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547348.1">
        <property type="nucleotide sequence ID" value="XM_014691862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVK7"/>
    <dbReference type="GeneID" id="26239911"/>
    <dbReference type="KEGG" id="mbrn:26239911"/>
    <dbReference type="OrthoDB" id="4996232at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="126" mass="14096" checksum="285AEC98E1168959" modified="2021-02-10" version="1">MGHTSEPDSGMKRAAEVSEAMLSVPGYADDSMFFTVRYGHKAKETLRKCDYDELMETLNKMTALWVKSGGGGAKPEPGAEERHAQIMELRRHCLEIIKDFPDLVRDFDRFHASSKAALSAVMRSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVP6</accession>
    <name>A0A7D5UVP6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g034330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546831.1">
        <property type="nucleotide sequence ID" value="XM_014691345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVP6"/>
    <dbReference type="GeneID" id="26239394"/>
    <dbReference type="KEGG" id="mbrn:26239394"/>
    <dbReference type="OrthoDB" id="5226996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="425" mass="47229" checksum="DE2A06A1FF334C80" modified="2021-02-10" version="1">MGPPRTRAQHFLAQRGRFQEGSMNDRVSAVPPVHFLGPQDREVLERPVYAEQSAYAAFDPAYFGRREERQPAQQMPQAQAQAQPQPRPTARKPTTKMNIFGQVWEGVRGRLRLRRDADDKEKVREKKDPASSDAQDDRPSRDEVFASYQQLVASGFFSSHAIQSTRHGPPPNYRPSTSHGVPSRNAGFAPQWPLAPRPLTPQSLPGAHEPTPQTVCSPVSVASSRGTKRAAESPEPSVDGDGDGEQGGREEERDDGEDESTLAHRFLPKRLRISASRDISLPKLRSVASRKSMRAAVALARRNVSVGAQEEDGKERELHKLSKKMSWAQQQQQQQQHGEVPAARASMDMLPRGRNSSEIHGSVTRRIRRPTSARNLRSAGMRDGNGGLKVVPDANRGIPRVPDIPAKFTYGEDRENGAPWRGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWL5</accession>
    <name>A0A7D5UWL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hse1</name>
        <name evidence="16" type="ORF">G6M90_00g039390</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547293.1">
        <property type="nucleotide sequence ID" value="XM_014691807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWL5"/>
    <dbReference type="GeneID" id="26239856"/>
    <dbReference type="KEGG" id="mbrn:26239856"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI68213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="629" mass="68941" checksum="5CDD87378A4191F9" modified="2021-02-10" version="1">MFRAQAAGPFDDVVAKATDENLTSEDWGAIIEVCDKVASDSNGSKEAVQSMIKRLAHRNANVQLYTLELAHALCQNCGKPMHREVSSRAFTDALLKLANDRNTHSQVKAKILEKMKEWADMFSRDPELGIMNDAYHRLKQTNPTLQAPSAPQKQGLTDADRQKEEDELQMALKLSLQDEERKKATAQAGPSTQSSGTNQQESAPVPAVSAGTTAATVSRVRALYDFVPSEAGELEFKKGDVIAVLESVYKDWWRGSLKGNTGIFPLNYVEKLTDPTPDELQREAQMEAEVFAEIKNVEKLLTLLSASNTAPREEDNEEISKLYHQTLAIRPKLIKLIEKYSQKKDDFTQLNEKFIKARRDYEALLESSMSHPPQHSYQQYAMRPAAPGQGYPGGGYPQGQPPQDPYYNQAPPSDHPHYQASSPAPNNFQSQGNPAPFYVAGAEVPSQAPGAQPQQQQPQQYPPRDDTPSLGPPSGKQPAPVNPSSPPPQSFTPYSPQPPQQNAAPYSQMPSQQRPQSTYGAQELATSVYDSPIAPHNPNPAPFGQQPYHSYNQPEQAPPPAPTGQAPPPPNSMSPAPLQPGGAAAYDARHGLPSQAAPETHPSQPQYKPYVPPGDGTSPNDYYRQGNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWV5</accession>
    <name>A0A7D5UWV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Superoxide-generating NADPH oxidase heavy chain subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">noxA</name>
        <name evidence="13" type="ORF">G6M90_00g047270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544848.1">
        <property type="nucleotide sequence ID" value="XM_014689362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWV5"/>
    <dbReference type="GeneID" id="26242189"/>
    <dbReference type="KEGG" id="mbrn:26242189"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="277"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="570" mass="65508" checksum="4AD2900E52170EED" modified="2021-02-10" version="1">MSYYSGVSDRPSERSRWTPLTRMLLSGEMTQEKQQDLSTREKFDRWMINEGYRRVFVFVFMLTHALIFAFASVHYSMKDSLQGARDIFGFTFVIARASAVVLHVDVGIILFPVCRTLISLLRQTPLNGIIQFDKNITFHITTAWSIVFFSWVHTIAHWNNFAQVAAKNKLGLYGWLLANFASGPGWTGYVMLIALMGMVITSVEKPRRANYERFWYTHHMFILFFFFWSLHGAFCMIQPDVAPFCTNIGASAIGVFWQYWMYSGFVYLAERIAREVRGRHKTYISKVIQHPSQVCEIQIKKQNTKTRAGQYIFFCCPAVSLWQYHPFTLTSAPEEDYISIHMRCQGDFTMAVSKALGCEWGRKADTSKVVGVDRDQHGVNPVLQRVLPRVYIDGPFGSASEDVFKYEVSILVGAGIGVTPFASILKSIWYRMNYPQKKTRLSKVYFFWICRDFGSFEWFRSLLLAVEAQDLEHRIEIHTYLTAKIKADDATNIMINDANADKDTITGLRSPTNFGRPNWDMIFRGIRKLHSPGEAGVFFCGPKGLGSSLHVYCNKYTEPGFSFVWGKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXP0</accession>
    <name>A0A7D5UXP0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxy-2-oxoglutarate aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g058320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544409.1">
        <property type="nucleotide sequence ID" value="XM_014688923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXP0"/>
    <dbReference type="GeneID" id="26242821"/>
    <dbReference type="KEGG" id="mbrn:26242821"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="34497" checksum="D49C3F945258D66C" modified="2021-02-10" version="1">MTASSSAAPQSNGYHNNVTGSPATLEPGIFVPTVAFFASDDSVDEETTKNHAKRLARAGVAGLVTHGSNGEAVHLDHAERKLITRLTRTALEEVGKAHLPIIVGCGAQSTRETIQLCRDAGESGGTHALILPPSYYGGLLNTDLIIEHFRAVADASPVPLLIYNFPAPCGGLDLSSDTILTLAKHPNIVGVKLTCGNTGKLARVVAGTQGTSFRTYGGSADFIIQTLSVGGHGVIAGLANISPVSCNEVVRLWKNSEVEKAVTIQGIVARGDWAAIKGGFISVKVALESYYGYGGLPRKPCAVLEGKALKAQVAEFQELVELETKVSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXW9</accession>
    <name>A0A7D5UXW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">mRNA degradation protein pet127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pet127</name>
        <name evidence="2" type="ORF">G6M90_00g062120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542663.1">
        <property type="nucleotide sequence ID" value="XM_014687177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXW9"/>
    <dbReference type="GeneID" id="26244612"/>
    <dbReference type="KEGG" id="mbrn:26244612"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="899" mass="101780" checksum="218EDCA8CAE556AD" modified="2021-02-10" version="1">MLRVRCCSGQLARSLHCTRAQQVASPLRRSRPLSTTQYLTTDPSDGKPAPSTQTPRKQDRDEQKPEETQKKWASFFKPEAVGQSETTLPSNGDSTPAEARDQSNRGIWTTLRSRMEVSKDNEATETAVLKNNEKDADTATSDEASEPTPKKGASKSKRIRGKAALDVKVIRPHKLKLKPVKENVSQQPPPHLSYNLDRVLFNPGVYHMQDHRSGVFNFDPYLASIMPVDEFDFDALKEYTTSSKDSKLRELCAAHGLKYCGSTSSMTSILSHFHFLLSAWRQPNFDSLSKSLTPESLNFTALSRGPAAAFAHFKDGVYAIDADKEYDTENILSMLGKSMEKLLTLPKEEFEKYRRSGSHKLSEEEKNAEEAYHFTTLGDFMMRSQLDAHDPRLPGSGVFDLKTRAVVSIRMDVKGYEKGVGYEIRKRFGQWESFEREYYDMIRAAFLKYSLQVRMGRMDGIFVAFHNTQRIFGFQYISLAEMDHAIHGTHDPRLGDEEFKGSIALLNDLMNRATQRFPGRTLRLHVETRPTKVPLTYFFVEPVTEEEMRKTQEAEKPSMEQLEREIQSLSREEREAESAGATETVPGETTKGEESDRGSDDISVDDPQNEDTWKEMMSKVDEAVENESLGVRSIREAVQEALEQSGLLQNKTELESEKYLDELVSALTAHSSEAKESRQAQADKDEETDEKKATDGQPDSDSTTLANLIVKVTRGINKNSTNLRPFERKVVDLATQARKADFIPAHERDARRDADDAELVESAADVDVDTKTDGSVPEEPTPELLGMYVTIRNKVNGEFVDRPFGAEKKFDWSVQYTITELPDKRAQSIYPKIKKRRKDVLATDPGARSADWYRMFKGKLPMMTKKGEKFRERRKQKEARSPVYVAWDKVPLPSNAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXX3</accession>
    <name>A0A7D5UXX3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g066330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540140.1">
        <property type="nucleotide sequence ID" value="XM_014684654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXX3"/>
    <dbReference type="GeneID" id="26246949"/>
    <dbReference type="KEGG" id="mbrn:26246949"/>
    <dbReference type="OrthoDB" id="4396271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="194" mass="21728" checksum="E9442CF3E0CCF949" modified="2021-02-10" version="1">MPKDILLRAIPDKHDGGRCYALVYAMSVALASSEFAINQLCAKLGALCPSKESDMESAAMFKRSLEDLHTSYLATEVSKPIRHMKFEDAIGILINSTDTTMIAMHTEFTVATFTSGNALLEATNKFFQRFPVVYEAKIECERPTFDLFPIDADKVSRIGSDYNLTVADLVKPETLLEIWHPIRRWGLSSEMLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXX6</accession>
    <name>A0A7D5UXX6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor vrtR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vrtR1</name>
        <name evidence="6" type="ORF">G6M90_00g056720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544262.1">
        <property type="nucleotide sequence ID" value="XM_014688776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXX6"/>
    <dbReference type="GeneID" id="26242674"/>
    <dbReference type="KEGG" id="mbrn:26242674"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="618"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="698" mass="78119" checksum="32D4EE7F8AE54CA5" modified="2021-02-10" version="1">MSQLVAIAPAPGKSPSAEAGVASTPDSATMQFNCQSCVRKKVKCNRTLPVCSGCHKGNLECTYLAPPPRKRRRVQDEDMNQRLARYESILRANGLLQPAPTSSHSGDAVTQRSNRHATEVLSNNQGPAEVGKLVSADGKSRYIDSVLLLPAGDGDLCELSDSDSEINEDDNEASRRDHSVSSNLGFLTGEAVPLAMLGRHQSLADVHPTHDEALSLWNAYVQNVESLCKILHIPTMAQMVDTISRKPASVSKGDECLVFSIYYLAVFSMPDADCLQTFNKQKHDLMAKYRSAVLQALVNASWLKTTSLRVLQAYVIFLVAARSQVDPHTFWSLTGIAIRLAQRMGLHRDGENLGLPPFEVQMRRRLFWQLLPLDTYAGQVSGTGISIAPDSWDTKQPLNINDDQIYPGMTEIPEEKKGATEMIYSLARIELSNFYAKTGVKLKSAAVSFKNSEEIENLINDVEGSIEMKYLRYCDILNPLHLLTLAVVRSAANIVRLRNRMKPVMDKTVNDGERNELCALSERILETDSTIYRNPSLKKFRWQVKNFFLWDALLCILLSISKAGFYKRAELDKTWNMVGEVYANHEDLLERKRALHFMICDVTLKAWLASPPKQPIPEPSFISSLQNQRKRKSRGPQDTISDTVSEMGSSNDAMEETSTTDGLFGHIDGTNLMMENNLNTNPSDWLFWDQFYRDTNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY45</accession>
    <name>A0A7D5UY45_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g067410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986936.1">
        <property type="nucleotide sequence ID" value="XM_066130853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY45"/>
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    <dbReference type="KEGG" id="mbrn:90967887"/>
    <dbReference type="OrthoDB" id="10317463at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028869475" evidence="1">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="201" mass="22329" checksum="7E969A4FFBFF0EFF" modified="2021-02-10" version="1">MKLLAATIALSALAAAVPQRPDMLYMVTGPCTDLRNTICGVNDMVEDPNVKGNRISCRFYQGEKQDDLLCQVNQLSKGQQAKDDASEICGALGGCTCAWSTTERKIRKRIGGRIVNFNCLPNPKSKNTPAAREQFLKSIDEAAAEACFWEKEMDESTCQSYKLDCIHTLSEGEHEDPITPDQVERCVRDRIRENRAPSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY59</accession>
    <name>A0A7D5UY59_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphatidylinositol phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">plcA_1</name>
        <name evidence="3" type="ORF">G6M90_00g056230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028958372" evidence="1">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="2">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="330" mass="37058" checksum="35A870DF3BAAB6DB" modified="2021-02-10" version="1">MLLFGLVLFLASACTARASTYHGYTSAYSFDANLSHQPDWMARVPDAANITSLSIPGTHDTMTYNLDSRVLQCQNWNLTVQMEAGLRYFDIRARVKENRLHIYHGKQNTGFTFKQVLLQMFEFLDKHPSEMIIMRLKKEGAPVGRDSYSFEAALNYARLQDKDTKDGAKKHVALYADSRKPIPTLGQLRSKIFILQDFKCAKGVTYGLTWDGPQMVLEDNFAIQGERRLATKWAAVDMALNRANQGPLKNDRLYVTHNSAAIGVLPIQAAAGVLNKAQVGMNYRTGEWLDAHIDDKTSMRTGIVIFDFPGKKLIDSVLAWNKHVGAKLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYM9</accession>
    <name>A0A7D5UYM9_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g064670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540077.1">
        <property type="nucleotide sequence ID" value="XM_014684591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYM9"/>
    <dbReference type="GeneID" id="26247113"/>
    <dbReference type="KEGG" id="mbrn:26247113"/>
    <dbReference type="OrthoDB" id="4940776at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="38742" checksum="FA54C6C1FF3EF4AD" modified="2021-02-10" version="1">MKQNQPTSSPRHRRTTRELPAWYCRLVILTITEDRDVAPWDFDEDISELGEDEGNESDGSDVAYTCDDEDDCECYLSGDDEESEHSYTGSDADYYYELKEQRTDRKMQLQDEKEQQQEERNSTREDESRKEQIVYAAYKAMLGVEKGGDGLRPVLESITNKSFDLYSVDHVDHCYHDFYRSKYVEFYHIDEDEECCKPPDGEAKITGHAYLSSDSGCQFVPFHPPKTAGCQKIPLKAQASECEPVFQFINNNYLIMTVKAKSNMISRDIRKPDAANIPDIFTFVGIHMDPMERKRQILEEMEERASKRRARSLSPRDTYFERSHPMGSWNMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYP6</accession>
    <name>A0A7D5UYP6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ferric reductase transmembrane component 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FRE3_0</name>
        <name evidence="12" type="ORF">G6M90_00g061410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYP6"/>
    <dbReference type="GeneID" id="26244677"/>
    <dbReference type="KEGG" id="mbrn:26244677"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="312"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="610" mass="68582" checksum="32052FA812FBA4E1" modified="2021-02-10" version="1">MDVTKTLESRGSPASEQVQPSSTIAPFYTALNGVNQPMNLFFRDVLWWTLGIAGIAVLVVRIMEILWAKLRQVSAMTVPREKQLYWKTSQFSWMPSVKKHLTYAPLWNKRHNREFKLSSAVNVGTLPSRLHMLVILGYLGSNIAYMFILDWSNPNKYSLCAELRGRSGTLALVNMVPLIIFAGRNNPLISMLKISFDTYNLLHRWMGRIVVAESVIHTIAWTIPAVADRGWRGVFESLIATPFIASGLVGTLAMIILLIASVSPLRHAFYETFLNLHIFLALVVFVCTWIHCATASVPGGLPQLSWIMGIMSLWFADRFARFFRLAYTNWSKKGFTDAFCEAMPGEVTRVTLKLPRYKSISPGTHAYLRFSGMKSWESHPFSIAWVEHCPDHLLPTYEKEEPIHGVLDKKQARTSVTFVIGAQTGLTRQLFTKAQMSPGGVTIRAAMEGPYAGHHNLDSYGHLLLFAGSTGITHQLSYLKYHLEGYNAGTVATRRLTLVWIIREYESLEWVRPYMDSILRIPNRQDILRIQVFVTRPQNARDVMASSTTVKLFPGRPNIPLLVSKEVQEQVGAMVVSVCGPGALADDVRGAVRAAQGETVVDFIEESFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYQ3</accession>
    <name>A0A7D5UYQ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g058490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544425.1">
        <property type="nucleotide sequence ID" value="XM_014688939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYQ3"/>
    <dbReference type="GeneID" id="26242837"/>
    <dbReference type="KEGG" id="mbrn:26242837"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028831396" evidence="3">
        <location>
            <begin position="19"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="385" mass="42069" checksum="276DAE213B88A019" modified="2021-02-10" version="1">MHASVILGAGLAIRAAAAVAVPTPSEPPVLRRDYDNNDNLPAAPWVTVDDNGNPSKTFTPVFTTISGTPSGIDPAPHDLTASVYTLTSFGHLSTSTGLPPNPTATNAGTNQGSFSRCYNKNGPYAPFCRPSYNSSIYTGNTYYVTWDPDYYNKSAATLNSTYFVSVRLDYLNTTSNEYVLLETIDKSVPAKWGYFPLAVDGKYLKGQKHTNNITITLMGHDTENSIAYNNKSIPLPVVVSNPPLDPTAPSNAPKGKTLTIALPVTLGVIALILVGGCLWNRKTRRIELGNIMSRSRQGYTGRRTRKLFNRSRKDNGIQLDTAPLSPPPFDYRDTVPERARRDSDALGSLTGSPVRGTFEEPGSTGGRNTFRDEVRRQERERRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ14</accession>
    <name>A0A7D5UZ14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g066800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539546.1">
        <property type="nucleotide sequence ID" value="XM_014684060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ14"/>
    <dbReference type="GeneID" id="26247629"/>
    <dbReference type="KEGG" id="mbrn:26247629"/>
    <dbReference type="OrthoDB" id="4114509at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="466" mass="51462" checksum="50075663B8C149A1" modified="2021-02-10" version="1">MAETISTDYLVIGAGAMGMAFVDTLLSDTKATAVIVDRYDSPGGHWNVAYPFVHLHQPSSFYGVNSKKLGNDQIDKVGLNKGLLELATSQEVVGYYSQLMYQHFLPSGRVTYFPKCEYTGDGMFHPVVTGKSFQVGKETRIVDATFMKVRVPAMGPPAYEVASGVNLITPNDLANISRAYGNYTVVGAGKTGIDTCLWLLGRGIEPSNISWIMPRDSWLLDREALQPGAMFSERRKQDQMARFQAAMSATSVDDLFKRLESAGHLMRLSDKVWPTMYRCATVSIPEFKQLGKIDSIIRMGRVICVGNGEVKLQGGTYKAKPDTLYINCTADGAAKLLPVPVFNGNKITLQPVRTCQQVFSSAFIAHVEATYNDENLKNEMCRPIPLPYETVDWIKTAILNTGNRRIWNSKPATVAWLLQARLNLDMHNAPEDPAERAAVEKQKDEMGEAVAQRLMELVGTKGQDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZM4</accession>
    <name>A0A7D5UZM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">mcm6</name>
        <name evidence="17" type="ORF">G6M90_00g073270</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545737.1">
        <property type="nucleotide sequence ID" value="XM_014690251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZM4"/>
    <dbReference type="GeneID" id="26241770"/>
    <dbReference type="KEGG" id="mbrn:26241770"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="469"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI70393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="945" mass="103620" checksum="68C8528EF842E241" modified="2021-02-10" version="1">MASSDAGYMMSDAPLQRRHMAFPSSSSTRPRGPPSENLGAASDDEGDAFADDQVPRSSRIPDAASVPRVEDRIGVLVQEHFEAFIESFAEDPLSSAPTSSAVTTDKYYVAQIRSMRNMQLSTFYVDYKHLAAWENGSLADGVMRQYYRFLPFLTVALHNMIAKYEPQYFREHRQPTASSTLSTSAASQLGSASQSDASHRKNEHQQTDKLFSIAFYNLPLVSRVRSLRAANIGQLLSISGTVTRTSEVRPELSLATFVCEACRAVVPNVEQTFRYTEPTQCPNGTCSNRVAWQLDIRHSTFVDWQKVRIQENSSEIPTGSMPRTLDVILRGEIVDRAKAGEKCIFSGALIVVPDVSQLGLPGLRPTAIRDDRGAPRGNDAGGSGVTGLKALGVRDLTYRLAFLACFVAPDTSSTGQPAANSAADIVNALTQSNSVEGADSIEDAQAAVLASMNPSEIEDLRAMVHGDHIYSRMVQSIAPMVYGHEVVKKGILLQLMSGVHKTTPEGMQLRGDINICIVGDPSTSKSQFLKYVCSFAPRAVYTSGKASSAAGLTAAVVKDEETGEFTIEAGALMLADNGICAIDEFDKMDVADQVAIHEAMEQQTISIAKAGIQATLNARTSVLAAANPVGGRYNRKATLRSNINMSAPIMSRFDLFFVILDECNEQIDRHLAEHIVGIHQLRDEAVEPEFSTEQLQRYIRFAKTFRPVFTDEARDVLVTKYKELRADDAQGGVGKNSYRITVRQLESMIRLSEAIAKVNCVEEIDAKMVCEAYDLLRQSIISVEHDDVEMMEEDESQEDGQVLLHAAEAASGRQADNTMAVDEEPPSSSSLVENADMKKKRTVTYDKYIKMVNMIVQRISDDENGSGDGVEGEDLINWYLEQQEEELEGEDAYHTERALANLVLKKMVKDNILMALRGEVLDGESSSSAAGVVYVLHPNCAVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZS6</accession>
    <name>A0A7D5UZS6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g079320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987158.1">
        <property type="nucleotide sequence ID" value="XM_066131124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZS6"/>
    <dbReference type="GeneID" id="90968022"/>
    <dbReference type="KEGG" id="mbrn:90968022"/>
    <dbReference type="OrthoDB" id="4689212at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11307">
        <property type="entry name" value="M35_Asp_f2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029482">
        <property type="entry name" value="HRXXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039124">
        <property type="entry name" value="PRA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39399:SF1">
        <property type="entry name" value="PROTEIN ZPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13933">
        <property type="entry name" value="HRXXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028906846" description="Putative peptidase domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Putative peptidase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="290" mass="31372" checksum="9FA9D05AF1DF3258" modified="2021-02-10" version="1">MYPVLAALLLSPSVWASPVGLRAETPTLAIPAPTESPSSAHQWAAGWKPSFNIHESCNSSLRAQLQQGLDETVELAQHARNHLLRWGHTSKFVDKYFGNGSTAHAIGWYDRIIAADKTEMLFRCDDPDRNCETQKGWAGHWRGSNATTETVICPLSFAIRRPLSSVCNLGYTVTGSKLNTYWATDLMHRLFHVPTISEGIVDHYSHGYAGVLELAKKDPEKSGIDTDALQYFAIDVWSYDIAAPGVGCTGKPPAESASPSGTSTTVPAATGTTSSAASCHTHDDGFIHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZX8</accession>
    <name>A0A7D5UZX8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Paxillin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PXL1</name>
        <name evidence="6" type="ORF">G6M90_00g074220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545644.1">
        <property type="nucleotide sequence ID" value="XM_014690158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZX8"/>
    <dbReference type="GeneID" id="26241677"/>
    <dbReference type="KEGG" id="mbrn:26241677"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="455"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="519"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="653" mass="71274" checksum="54DF66A670AD26C2" modified="2021-02-10" version="1">MALPRESTFLPTIKCSLCGNQVEISMMGDHLCAGPTAELSPPLDSIDEFESQFAKPPYPKHATPPPVETGSMGQTYMHRGQLTPISQPSESRDASPVYPNRRESSRRAHESFGSRQPIDARWETPMSANPSTRSGGYGGFEETNRENFDKPLSGGFMARMNTSVPGPFDPMRAKNSYPQRNDSLEKLVPSEEPLPPRQPRKDGYGGFGAPKNLDSNGSATLSRSETYPKLSPTTNYFQTQRVTSAPGSHPERLRTGGGHGHEYKRSIGPDTSRKPPPRTSLLPEYSLRNAGSVDLAAEFGIGNPYHTPSDSASSVGYSDSSRASRSTAVTSPTSSEIYQADQNRDMNEAGFSTDKLKPKDLRIDPFAAASRTRSPRMVESPYGLSPTTQFDGALGNDPRRPPSRAGYSTSPTQDSNYTSAGFRNDHGLTEHTSPQRQHTWERQGSPKRLALPSRGDCKSCGLAIKGKSISSADGRLTGKYHKACFVCTTCAEPFSSSVFYVLNDKPYCEQHYHELNGSLCGDCGRGIEGQYLEDEARVKYHVGCFRCLDCGVSLSQGYFEVDGRSYCERDAWQRVQPAASLEPEPYRRGPPRGAVGTRIPQGLPARPAPRLGQGGRPHPPPPNGIPNGGRLGVGAGQQFKMNKRMTRLGNMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZY9</accession>
    <name>A0A7D5UZY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serum paraoxonase/arylesterase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PON2_1</name>
        <name evidence="8" type="ORF">G6M90_00g066960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the paraoxonase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539562.1">
        <property type="nucleotide sequence ID" value="XM_014684076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZY9"/>
    <dbReference type="GeneID" id="26247645"/>
    <dbReference type="KEGG" id="mbrn:26247645"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="439" mass="47792" checksum="2F9110BECBF2C130" modified="2021-02-10" version="1">MAGGPSLASSGAILILAIFAAFLYTAELPRAKVVLGFGRKQSSTVVANANDFHTIPDTVHCEDLHYHEPSRLIFTACEGVEATRYAWFPALGHFDDPNVGLKAQGSIEVIDPSTMKAKKLKFTNFNGPFVTHGIDVIDDPDKPKGKAVYLFAVNHLPNPAFAEDASEPKARSIVEVFYYDIGSDSVEHVRSVWHPLITTPNDIVAVSPTSFFVTNDHFYRDGIKREIETLYFGAKWSNTIFVEFTELTDGSFRDSDVEVKASVALDGVHNNNGLGHGRTPSEVLVVSCASGRLHIADVVSPKSDGESPRIAIRQSVAFDSTLDNPSWFRDPYANSTYDASGLVVAGLPRAVDLAKNQHNPRGTDGAIVWKATPSRDETAGNEESWVNRLLFEDDSTRIRTASAAVLVAIDPAKEKGERKAWLFVTGFISTNVVAAKVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V029</accession>
    <name>A0A7D5V029_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g079770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V029"/>
    <dbReference type="GeneID" id="26247286"/>
    <dbReference type="KEGG" id="mbrn:26247286"/>
    <dbReference type="OrthoDB" id="2679825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="185" mass="21251" checksum="603CADD30B178CB1" modified="2021-02-10" version="1">MPSDKDRLYVALYARGGAPTMPGLEDTYHWALIVGPKTEDKRSRGARFHAREKMRLIGTGAVPESVWEYEELESTMLPTSMLLVRVMIGKVKDRNRLESLLRNIPIRPRVEGWNCVAWVKEAIETALRDKKVLGTSKNLDWDSIRDTAMWYVGQKKAAHRFDGQGEFDREKAATWDMIDGFERVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0B8</accession>
    <name>A0A7D5V0B8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g063830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542502.1">
        <property type="nucleotide sequence ID" value="XM_014687016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0B8"/>
    <dbReference type="GeneID" id="26244451"/>
    <dbReference type="KEGG" id="mbrn:26244451"/>
    <dbReference type="OrthoDB" id="4935409at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028877530" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20259" checksum="718060E6EFDF4F5F" modified="2021-02-10" version="1">MKYSALSAISFLAVSSLGLPEFYWGVSKASPGQIIVTNNMNRPVRLDKVAQGPSVDGVKIIRDQEIILNQGQTVEVSATEISADLKFNEQQAHNQVELSYTSGDQDTYNFAIKPIEGSGFPGAIEVIPLSPRPSPQCHPLVWYPGQGNTAQATCQDHTPLRVFLREAHHPPEFNKFDKFDGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0L8</accession>
    <name>A0A7D5V0L8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-rhamnonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rhmD</name>
        <name evidence="5" type="ORF">G6M90_00g070100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987210.1">
        <property type="nucleotide sequence ID" value="XM_066130927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0L8"/>
    <dbReference type="GeneID" id="26246538"/>
    <dbReference type="KEGG" id="mbrn:26246538"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="451" mass="49801" checksum="0B318D4DF2ABC0F5" modified="2021-02-10" version="1">MASAVREFPTIKAVRSYVISGVGSGGDYHNVKDGHWLIDSDISTPCSIWEQYRKSRTSWGINVLGSFLVEIEASDGTVGFATGFGGPPGCWLIHQHFERFLIGADPRNTNLLFEQMYRASMFYGRKGLPVAVISVIDLAIWDLLGKLRNEPVYRLIGGATRERINFYCTGPQPTAARDMGFWGAKVPLPHCPEEGHAGLRKNVAFLRRHRESVGPDFPIMVDCYMSLNVSYTIQLVEACKDLDINWWEECLSPDDTDGFRQIKRAHPATKFTTGEHEYSRYGFRKLIESRDLDMVQPDVMWLGGMTELLRVAAMAAAYDTPVVPHASGPYSYHFVISQPNTPFQEYLANSPDGRSVLPVFGDLFVDEPIPTRGYLTAADLDKPGFGLTINPAARAKLIPARNLLAPAPVAMPAPEMNGAAKEDGDVKHAKVNGVGHHDDDELVGGMGKLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1D8</accession>
    <name>A0A7D5V1D8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g090560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541714.1">
        <property type="nucleotide sequence ID" value="XM_014686228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1D8"/>
    <dbReference type="GeneID" id="26245577"/>
    <dbReference type="KEGG" id="mbrn:26245577"/>
    <dbReference type="OrthoDB" id="5235778at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="353" mass="39665" checksum="85F5B0E41CEE77CB" modified="2021-02-10" version="1">MESEAMARGRVTLRSTSTWRQTWEANIDEGTEYSPEDAAYSNLEDKRLKHAERQRAAQSKGVQLGTWIDSQVLQEDRKHAVTGFIDTVGRLQTHVLPETKHGESLASESPLPPGSGRCWIRFSKIKFSEHLHGLDHLQIKEYIRVLSESRETRGRVPGDEAAAVQAAKYRLSKDPNWVKSKKRYIAYSDAESGLARVRSSRAAAVHWGRTGPLPVHSLHCEARTRERQLQDVGVTKEAEVLAHGGNGVAQNQADGRMMDRGQAVEAAAATSSTGRRMLFREWKDVQRFDDMCGVQETPRRGKSIRRAKMYNGITYERQTTGAFIGKLVSRGLLIHIDGEDYLEHRVLAMPGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1S4</accession>
    <name>A0A7D5V1S4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g085840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541143.1">
        <property type="nucleotide sequence ID" value="XM_014685657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1S4"/>
    <dbReference type="GeneID" id="26246132"/>
    <dbReference type="KEGG" id="mbrn:26246132"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="38266" checksum="EED32E9BF462078E" modified="2021-02-10" version="1">MPIGDLLAQISGGKSTAASGPGLKRTDSIPSKRKPNDDLRGDGSKTSRVMASSGGVGQTSRSSGDRSNLQQPYTGSARPGNTPGSKVAGSASKPPKSTKPGLPSRPAPSPAAAAPKAPPKKGSFAEILARGQRAQATMGQVGKIQHKKVEKGAIKKARDEPPPATSSKGRNVGGYVGTSKPGQRNGVNGHKRPPGRPIDTRPGAGARVPAARGKAAAAAAAEEEAAKKVKKAAQATTGYTGTARPKPGNPARKKDVPRGGALLNATRHSTSKNSYEDDYDEELDDFIEYDDEEDEGGPRYDYDSEGSSDMEAGLDELDKEERRAEFIGRREDQDEERLEKTLKAAKEDRKRKALEALRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1X5</accession>
    <name>A0A7D5V1X5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pyruvate, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ppsA</name>
        <name evidence="17" type="ORF">G6M90_00g084050</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543621.1">
        <property type="nucleotide sequence ID" value="XM_014688135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1X5"/>
    <dbReference type="GeneID" id="26243798"/>
    <dbReference type="KEGG" id="mbrn:26243798"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000010">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000017">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005057">
        <property type="entry name" value="PRK06464.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="15">
        <location>
            <begin position="33"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="14">
        <location>
            <begin position="402"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="16">
        <location>
            <begin position="494"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI72730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="813" mass="88755" checksum="F994161F0A8BE7EF" modified="2021-02-10" version="1">MKHGHEMRQKTHNENPEQPLILRFDQVRRQDGPLVGGKNSSIGEMITALTNRGIKVPPGFATTSRMYWQYVGKNDIQQHAARLIAEWQYGKLTLSEAGHKIRSLFLGGTWPSSAAAAIKAAYHELCGETNRENLGVAVRSSATAEDLPEASFAGQQETYLNVSGGDALLDACRRCYASLFTDRAISYRQTRGFDHMSVALSIGVQQMVRSDVGGAGVMFSIDTESGFDKVVLINAAWGLGENVVQGTVNPDEYQVFKPFLVDRSLVPIVDKKRGDKAVKMVYGDKDKGAPTRNVSTSKAEQAAFVLGDQEILQLARWAYTIEQHYRVPMDMEWAKDGVTGELFVVQARPETVHSGRDAAVFKVYKVRSKGRVLATGLSVGDAAVSGRLCLVESSRDLDKFVDDSILVTGTTDPDWVPVMKRAAAIITDHGGRTSHAAIVSRELGLPAVVGTGNATYVLHSGQDVTVSCAEGTAGFVYDGAADIATETLDVSGLPATRTKIMLNLANPAAAYRWWRLPSDGIGLARMEFVVSNAIQVHPMALVHFDRLKDEEARSKIAALTAGYAQKPDYFVDKLSQGLATLCAAVYPRPAIVRMSDFKTNEYAGLVGGAEFEPDEENPMLGFRGASRYYSPRYREGFGLECRAVRRLREHMGFTNAVVMIPFCRTVREAKMVLEVMAENGLVRGEKGLLVYVMCEIPSNVILAAKFADHFDGFSIGSNDLTQLTLGVDRDSGELADLFDEEDEAVKWMLGRVIAVAREKGCRIGICGQAPSDHPELARFLVDSGISSISVSPDSFLAVKRQVVDSERALSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V233</accession>
    <name>A0A7D5V233_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g091100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541764.1">
        <property type="nucleotide sequence ID" value="XM_014686278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V233"/>
    <dbReference type="GeneID" id="26245627"/>
    <dbReference type="KEGG" id="mbrn:26245627"/>
    <dbReference type="OrthoDB" id="2446447at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02219">
        <property type="entry name" value="cupin_YjlB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047121">
        <property type="entry name" value="YjiB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448">
        <property type="entry name" value="BLR7373 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36448:SF3">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="214" mass="23389" checksum="47363982E9685D56" modified="2021-02-10" version="1">MPSPTVYQIRPTKLVPNSPKPLLHYKGYFDKDEKPDAATIHDAFQRNGWDVQWVTKYGKYQRSHYHPETHEAMAVLSGPGIIRWGVADTDDDGDKHTYGTAHEDGALQTEANVGDVFVIPAGVAHKSFDPQAPDPDAQCLTGGYHGIDGENPRETVGRVPLSGFTMMGAYPRGCSWSWAEGGDHLARFEAVWNVPLPTLDPVVGGEGGVGAHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2H7</accession>
    <name>A0A7D5V2H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g085000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541060.1">
        <property type="nucleotide sequence ID" value="XM_014685574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2H7"/>
    <dbReference type="GeneID" id="26246049"/>
    <dbReference type="KEGG" id="mbrn:26246049"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="463"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="923" mass="102117" checksum="1A2034033A182B75" modified="2021-02-10" version="1">MFNLPPDKSRASDFNTDSYGFNNQAWSAFDFGQGAPSSSSLAPEHNHDTRQSFSDAGGMEWAPTSSNVQPNYTNGHHEHQDHQGDTAMELEALSSPQTGGGVGRLVAHFENKGFNPFENKSFEPPPPLPPRPVNTTVNNNQSHHQAHQQVEQNPSISMNSFQASLSFDPLSYCGNGISSTASSVFNPNRITNPVTGTGQSWGEFASLQRVTSPIVASPPAMSYSNFQDNRVGSSSAHFGNLDDFMSDNRIHSSMAHSPIPDSHLASSPLVASPMTQSLSHSNAAPVGGTPGFEIWRPPGTTANTTTKMNQSQPNNFTTPLSTTNSFINPSGSHSTATSTTNRNSIGGRNSTNSAGFLKPPVPTTPKPNIGVGNQFILELIPSAKAKGKAPAKPPRPRVPPPAPISFTADIKQEPMTPSPSQIPPASSTPTSLTPSTTLSDHKPGSISLRGQAGTRPSREQVPAEAWEQFKGTIRSLYLEERKPLKEVMAIMAEKYNFQATPKMYKTRFSQWGFVKNNTEEEVKKLLSMKFQRDAEGKVSEFVRNGRVVNLGTYLKRKGVTEYDLVDFELSADLPAHVRCRTPTPPPAPGYLRSPDLLRAQELVVGNMRKAFLHCRQFEVETDARIGWPITMVWGAGSSDLLLEANFYFEARDADQGGDFLMKAFKQLELDLKKLSPLGINELLLGMVHRDPGMMTALCKYLAAYSSTNFERSHPLRQIFACLYEVQQKHGSATVSELLWGSMPTIAEELEAIYSRRHPYVTRTWIDLALFHNHVNADRLDKLASELRLQQRQVEQRYGTNSTDALTLRYSILQLLYVVNSQSDLTRHAAHDLWNHLKSMCVVFGLRDAKPNVFCYHSPVKVDPWTKRCRRRYDSGVAILEEHVGVRVQPYFEEDFHHAVHVPDAQEAWSSALGHMSSGKYSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2S3</accession>
    <name>A0A7D5V2S3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor 3B subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Sf3b6</name>
        <name evidence="9" type="ORF">G6M90_00g101280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987624.1">
        <property type="nucleotide sequence ID" value="XM_066131587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2S3"/>
    <dbReference type="GeneID" id="90968179"/>
    <dbReference type="KEGG" id="mbrn:90968179"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12241">
        <property type="entry name" value="RRM_SF3B14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000286">
        <property type="entry name" value="Putative pre-mRNA branch site protein p14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034150">
        <property type="entry name" value="SF3B6_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="14"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="165" mass="18316" checksum="07CE8FF2A20F1C88" modified="2021-02-10" version="1">MSSRGGKLAPEVNRALFVKNLSYSVTPEELFDLFGKFGPIRQVRQGISTSTKGTAFVVYEDVMDAKQACDKLNGFNFQNRYLVVLYHQPEKMMKSKEDLEARRESLAQLKKQHGRSLSPPKSASSDHKTILRKGTPLDSTINKGHVGSRAVRFVDGAPTALRSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3D2</accession>
    <name>A0A7D5V3D2_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g083420</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131224.1"/>
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    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
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    </dbReference>
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        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="2">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="280" mass="30744" checksum="025EF3D8D8A0B607" modified="2021-02-10" version="1">MPFIGIQESSTWSVALTANMNTRATGLPKTSAFYCPQPVYNPTCISDPTASLHLPHHNAHQNSREQHVSVWVIPEPRHVFQIQQHRYTFHVAIPIRIHESSTWQVALTANANTRNRAESYYYRLGNTSATSKRRSIRSLKKIKTSDLVFNMYSICKAVAAAVLAFSLAATAAPAAGEEHMNHLAARNAGDFTYYYTGLGACGETNNDSQMVAAVGHDLFDRSRPCGRMIRAHYGGNSADVKVVDRCGGCNDDSLDLSPAAFQQLVGSLGPGRVQGTWEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3H1</accession>
    <name>A0A7D5V3H1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g099770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690886.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26240795"/>
    <dbReference type="OrthoDB" id="5578001at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="378" mass="40978" checksum="C41835A3B7423527" modified="2021-02-10" version="1">MAVVISPPDQATLLAPLLPALPAAAASTQPALQLLPLLSPILRQRVQLLSASSTEPWLRLLCYDASKAAKLADIARGPTLEPHPVSGEVEVDWGYDSETHYRRLDEETLQALVALPELGLAFRLVYCVNDKEGGGDGWRIGEVTIAERPGPFSQFGGASSIAEAEKQYKDKEAKSKDTLRVNGTAAKSTLGGNDDEDDDDYWARYDATPARTPANNRSPAPNTGDARPSHHQQDGPRSAAEDDYFAQYDDVQPAMDNHDPDEEAQAAQLLGPLGFQQNPAAAEVNQNGGIQQDVSNAEIALQHPRPESSASSNGSRTVAKLEETAGKQEQNEFGVKQHVSRTIRSLYMLSKASGIDREEFERLVKTELDLLGIMDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3M3</accession>
    <name>A0A7D5V3M3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540802.1">
        <property type="nucleotide sequence ID" value="XM_014685316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3M3"/>
    <dbReference type="GeneID" id="26246415"/>
    <dbReference type="KEGG" id="mbrn:26246415"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11680" checksum="A083308AA812FB3F" modified="2021-02-10" version="1">MAPIHRVTLFKIESENDRQHLLELYRQMPTKAVKDGKPYIQSVTAGPTKPDQRAQGFTFAAISVFASLEDMEYYDNSCAAHANLKEFAKKAHSGAMMVYLENGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3U3</accession>
    <name>A0A7D5V3U3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g096370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546697.1">
        <property type="nucleotide sequence ID" value="XM_014691211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3U3"/>
    <dbReference type="GeneID" id="26241120"/>
    <dbReference type="KEGG" id="mbrn:26241120"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="122"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="319" mass="35098" checksum="71B54E1E21F42356" modified="2021-02-10" version="1">MTKPSLKQTTLNALANSFTPASALALGKKKATATEANAKKGIKRKTGRKGLRNIQPPQASVPSKTQNPPPNPAILTPKTTSPSEDDAKPPKPRQPPSLSSGGIPSPSTHYLTQSLAPPTLLPQPRRILVILDLNGTLLHRPSPRRPSHFVERPHARSFLKYCLDTFHLAIWSSARPQNVNNMVAQLLTPDECARCVVVWARDRLGLSGDDYDARVQVYKRLSSLWDDPRVRASHPDAAAGSCWDQSNTVLVDDSREKGRSEPYNILPVPEFSGLQAESPHVLPQVHDYLNALCFQADVSRYMRENPFRLDSGYTLPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3V0</accession>
    <name>A0A7D5V3V0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FluG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g113580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987834.1">
        <property type="nucleotide sequence ID" value="XM_066131893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3V0"/>
    <dbReference type="GeneID" id="26247414"/>
    <dbReference type="KEGG" id="mbrn:26247414"/>
    <dbReference type="OrthoDB" id="4958261at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="85575" checksum="B88EC058EDC19AC9" modified="2021-02-10" version="1">MATKRKSPRIQHPPEYYRSKRKHLAKHGAIRKRHADTTKVNMHGVKLKWTRHCCHLSVNDISHLENASKEDIMTFLEWMLDTYRRIRKRSTVHAYKRILFQVYRKSVGVDFNNQANEEINDVRSAYLESKTPFRDLDLHLVQYINGYLTIRYKLDTSINEKPVMDVDDVYLVQHHHWVHDTSVFPDERQRIQLALLILLQAYTATRPRVFAYKKLNRKAINDHYFSIDDEDTESEDYTEEWDPKEDDFKTITYGDVKLILIKNPEEGRDLPAMEVTLRYTKGWERRENPKTFIFYEVDDLLFDAVLHLLALAILDQAFEANIQTVQDFYKIKVRPPRRSLEFEWRKDISNKPIFRQAVPTSDGTVRTSDTEALRYHTYLYYLQRLGLVTGFMQILNPYCIRRGAGEGVEAVATQAQLQQVMCHINAATYQAYINQRVQCDTVAAFLGRPSNKALLKAAGHMSRNVDPRAPTNASHLELENIRTNPTLVKLIELRDSLSREVRRESGSIREAEVHGTKLHQLYRTVENKVRSTRAYLRKLAKATTRQEFFSTISTLEINSQLEDEAGSLLDLGPDTWSPQPSYNLEERRLLAELICADTCDLDDGMKLKHRIYTTNAMILLGREREQRRVKSGAKIKTDHFPTKCETNQCFMCFWDDRAPPSQRFKKFCSSYRARDHLISRHLKGLVEHSVMCPEPRCRDKKLVFHELQSLQAHLTAAHSYNNFNRYKGLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V405</accession>
    <name>A0A7D5V405_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ERD1 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">erd1</name>
        <name evidence="7" type="ORF">G6M90_00g103210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546027.1">
        <property type="nucleotide sequence ID" value="XM_014690541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V405"/>
    <dbReference type="GeneID" id="26240450"/>
    <dbReference type="KEGG" id="mbrn:26240450"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="190"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="45731" checksum="8C6665D88ECEB03A" modified="2021-02-10" version="1">MDGDPAVESELDAFSLVFPLPFRVGFIATLAVWGWGLNLHYLYLAKVDVPSLIRYPGRSSPHHIPHHLSTYRLATFLSGLFAVSMVLFWLCTWGAASRVIDYDWIPMTYLAGIVAVFLVPLKNLPSGGRRRFLATLKRVSIGGIAEAQDGKFGDILLADVLTSYAKVCGDVFVTLCMFFTAGGSSTKRPDRSCGGTVVVPLLMGVPSAIRFRQCIIEYLRVRRAPYKESAGWGGQHLANALKYSTAFPVLVASALQRNTDDAAARAAYNRAWLVAVLVNSLYSFYWDVAKDWDMTLFASRRERNSSHHPWGLRDRLIFRPVIMYYAVIVLDLMLRCTWSLKLSPHLDKFSDFESGIFLIEFLEVFRRWVWIFLRVETEWIRNSSTGLGIDDILLGDYQGKDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V488</accession>
    <name>A0A7D5V488_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dioxygenase himG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">himG_1</name>
        <name evidence="1" type="ORF">G6M90_00g113950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539698.1">
        <property type="nucleotide sequence ID" value="XM_014684212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V488"/>
    <dbReference type="GeneID" id="26247529"/>
    <dbReference type="KEGG" id="mbrn:26247529"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="301" mass="33891" checksum="1F2A6B6C7B919567" modified="2021-02-10" version="1">MDVAVFEYNVNLKADEIVASLVQNGGCIIRNMISDRRILDTIERDVRPYIEADRPWVGVDFFPPETRRVMGLVGKSQAFTQNIPANQLYRDVCSRLLSSTHKAWLGYQLNTTVSEPQLSNTIVFSIGPGAARQELHRDDSIHHNSLPELKHHNDYRIGRDTSVGLFVAGKKTTRANGATRFIPGSHLWGEDRCPSEELAYYAELEPGDAFLMLASCYHGGSANTTKNEERLVYSCFMTKGFLRQEENQYLANTIGQVQQYSPDIQKLIGYSVSKPFLGWVNLEDPIKLLHHGSEIIGDGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V506</accession>
    <name>A0A7D5V506_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein pob1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g103360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546012.1">
        <property type="nucleotide sequence ID" value="XM_014690526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V506"/>
    <dbReference type="GeneID" id="26240435"/>
    <dbReference type="KEGG" id="mbrn:26240435"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="174"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="655"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="91765" checksum="AC26DB1D482E61CA" modified="2021-02-10" version="1">MEYEYAYYRPGDSQAYQEMRQKFTRDAFFRLGNELQMQRPASVATEFVDTDWDEEIMSEAEDNSPRVSLQSSGQPSFTTVSSYDEAPTPRSSRGREAYPEHIFKPVEGPSGPHLFRSSTDSPLVDDDFILTLSPVTPKAQRGIGDLLDRPPMPRRSGPFQYTSVELDSLPLASWTPEMVAQSMLNAGIELSVADRFIENDINGAILITLKFEDLRELDIQSFGIRTKVWHQIQTLRDSRPSSPRPATPIEDAPSREACRETRNKAQTGVNRSQSNKRRARRKLSAEEDIVHPMESVSIIGIEQVIPKPHNCSKGENCHKWRKNQKLLNDLKKANPTVDVYAGRSVMIFGDAGNPETARAIDPHETFRPVSDAVPSVVASSDVMGPGGLPPLQYLQEATLRGIQARDPQDNVRQFLKFQQKNSSDQVPPTPPFEILPSAKMPHQGLRQLPKLSIPGKPLQGTPLRTSTVPQPTEPQRQELAAGQPVQQVQRQAIQPPEFVPYRMNKADPLSPDLETPRNPFRFGTPFSELDVPITAVPAGPVARDTSQSVPPDMNYRVPHAARSQSRASNRRPSFPILPSVDENGVVLQRSKTPSPKSTSPIYRVQQQLQKQPLRAPPRFNYPWSPAERSSFENAIPPASTLHPGGGHDALAMASGITHQGPMKKRKTRLLRNEWQDGYFTLKGSRLNMHKDGQELDRTLEYIDIDDYAIACSSLASTSKLNAAFKAVRISHNREKSDPVGAFSFQLIPQDKSAGTRLRKRDSSMSGVNGNSTPSEGVNGTGKTHHFAVKSRDDRIDWMRELMLAKAMKQKGEGFEISVNGNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5E8</accession>
    <name>A0A7D5V5E8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g106440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539861.1">
        <property type="nucleotide sequence ID" value="XM_014684375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5E8"/>
    <dbReference type="GeneID" id="26247300"/>
    <dbReference type="KEGG" id="mbrn:26247300"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="372"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="654" mass="72605" checksum="11C4BCCD993C11AC" modified="2021-02-10" version="1">MAGSTLFMTPEESVRVQKTVQDLRRKCQEEKGQRREPNDAKSLIQQATGSSLMEDMASSLFGLSQQRNSPDTMPAYAVGSPYLPCTTALSDLKPMGLSDLCMETHHRGHVLKVRRASPVVALKASSWAVVQGQSVDDVERIELFLHKSKYGQELLDLGSVFLVKEPYYTLNSQGEPVIRIDHPSDLVISTYSDGPESWRNTESDSVSTARTAVMCKEEGNAALGKKDFPRAHARYTEGLSHIGKDDEASNTLSNDLHRNRAYINLLLQRFEEARSDALSSLTHSDGPDEKLLDAKAYYRAGTAAYSLGDFEDAKRFFDEQLKLEPDNRLAQINLRRINKRIQEQTAGVYDLSKIVSNLPKTQGRADAASFNGDTEVKESPGAGRGLFARRDFQPGETIMCEKAFCVVWGHEPGAFSTLTCDVRDDAAIRVFPAGLHKAVVQNLLNNPSQAHKVLDLFSDYKGLGGKPLEQDGNPVIDTFQIHDIVQRNAFGPGQQTEDEDVTNASTGLWVRAAYINHSCVSNAKKDYVGDLMLLRATRRIAAGEEITHSYDESSGYDSRTAAIQRTWGFKCHCALCAAEEADGPALRKQRLELENEANALLQKENPSGANRISINRAKRLQQSLKDTYNDKRYKGLPRRAMSGLEQWLKTALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V742</accession>
    <name>A0A7D5V742_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OLA1</name>
        <name evidence="6" type="ORF">G6M90_00g110400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543819.1">
        <property type="nucleotide sequence ID" value="XM_014688333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V742"/>
    <dbReference type="GeneID" id="26243206"/>
    <dbReference type="KEGG" id="mbrn:26243206"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="306"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="394" mass="43913" checksum="D0140D9FFFCDD7FA" modified="2021-02-10" version="1">MPPKKVVQEEKIPLGRPGNNLKSGIVGLANVGKSTLFQAITKCNLGNPANFPYATIDPEEARVIVPDARFDWLCEKYKPKSQVPANLTVYDIAGLTRGSSTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIIHIEGDVNPTRDLDIISEELRLKDIEFVEKALENQKKKTRMGGQSLELKKAKLEQDIIEKILAWLQDGKDVRKGVWGPKEVEVINPLFLLTAKPVVYLVNLSEKDYVRKKNKHLPKIVEWVKEHATGDPIIPISVSYEERLTRFETEDESREEQKNVGAESALPKIITQMRKTLQLGSFFTSGADEVRQWTIRTGTKAPQAAGVIHTDFEKTFIQAIVYNFDTLKELGDEAEVKAKGKMMTKGKEYVVEDGDILLIKAGAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKE7</accession>
    <name>A0A7D5YKE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g023700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548186.1">
        <property type="nucleotide sequence ID" value="XM_014692700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKE7"/>
    <dbReference type="GeneID" id="26237630"/>
    <dbReference type="KEGG" id="mbrn:26237630"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="241"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="845" mass="93597" checksum="95EAA0144C103D21" modified="2021-02-10" version="1">MTHEQMLDNAQRVPSNSLRGPRGPGLDYAAELENRMPIRQEKVDRIEKLGRRESKLGLRNIFGRSKAARDDQQPSTTPATLKKTNFRASMARVSQPPLVYQYDSNLPTNFSWKPLAATAEDPDAEQSSHRNVPPARKKRSNSRVSGQPDDSSTNWTLPPLFKAFPQAVHHATLPTATISADAILRINEKKNSLQTKEEEDLADGAGNDHLDADMDKHRKKNNKWELNAPATNFEWTTKIYVLVTSGYLLQYSRNGTFDRLPEKILRLGPSSAAFAADAIPGRHWVIQVSSVADDYDHQGLESRSIFSKLSFRLTERRNASNLLMVFENAEDMEGWLAVLRNEIEKQGGRRKLSETGKPKPAGADPYVREHMSQRTLIVRDPSRFTSSRSRASQSIMSPPRETRSSETFTRQTSTDTARHQSLDDISTTNSMMSQDERQLESLRETSNRLSFVSCGQRTFVTSTVSSPDGSPTHDKFDEGIFGHHESSGRGEVRTRPNASEIVTRRESVQATAPFIDDGLAPKGKMRSLPTCVTDVHPDRVNSPLGVKPTPNFSVPRSSTRRFSYARGATSTTDGSPSRRRDRDTSPRRFGRTLPTAMQSAHRLSVVIDQGVSRAIATERLPTSPKSPPLPTLPTMDVGQRRLRSVSRGRAGRRGDDQVSQASHVPDSIPERSSWRLSPRKQSSTGALRQGIPSPEPPLAVVNRRPHIASMVVPTGPPVIDGPPRGHRTSFLDIGESTGDMIRSQSLEPSRAAKRASMCSVFSERSSRSYEVHDSTVSSHHSSDSSATITSESQPTSGHYLNVEKTPRTSPMNRRSMPQIAVSGPPPAPPPTRALPPIPQKMQIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKL2</accession>
    <name>A0A7D5YKL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g010410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985636.1">
        <property type="nucleotide sequence ID" value="XM_066129689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKL2"/>
    <dbReference type="GeneID" id="90967446"/>
    <dbReference type="KEGG" id="mbrn:90967446"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="53" mass="5798" checksum="14A252C185DD7001" modified="2021-02-10" version="1">MQVWEAGEDEAGLTKDCEKSAVEIPLVSGFFEDAEMYLADVSDVPVKSSFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMH4</accession>
    <name>A0A7D5YMH4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g015480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548979.2">
        <property type="nucleotide sequence ID" value="XM_014693493.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMH4"/>
    <dbReference type="GeneID" id="26238423"/>
    <dbReference type="KEGG" id="mbrn:26238423"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="355" mass="39933" checksum="11AB0D3C9059535D" modified="2021-02-10" version="1">MDKLGVKAVLDGAMCSLALHLVGKENEDESMVAHSRTIYGHSLGQLQTSLRHETEWKTSETLCAAMLLCIFELFAGTNSSDSWLLHARGIGTLIEQRGPNAHSEGWDASMILAFRGVLIMCDMFFPSGEGCFLSRPEWKAVARDGGRHLIHPAAHLVSTIHVIDEFFERLAEIPSVLAPTFVLRESKTMGTLQQPDDVEIASLALRSIEYRRLFNAWYDKFTTIAPLPYDIPSQDPDSPFDFVLQYNMSWMGSMYIGYWACLLILQEALVQCEWPEEFEQSRGELVRNILRSIETVGAGTMGPYRVGFGIRIAYELASAELQLWVRRVLDRFKKTYAATDKSTYPAPRTDDGGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN65</accession>
    <name>A0A7D5YN65_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">G6M90_00g000650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543003.1">
        <property type="nucleotide sequence ID" value="XM_014687517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN65"/>
    <dbReference type="GeneID" id="26244376"/>
    <dbReference type="KEGG" id="mbrn:26244376"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF27">
        <property type="entry name" value="GLYCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="532"/>
        </location>
    </feature>
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        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="16">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="420"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI66300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="532" mass="56990" checksum="122EC47FFBAAF674" modified="2021-02-10" version="1">MLYNSIVAATALLGLAAAQVHTDCNPMERDCPANPAFGTDHNFNFNSTPSSDLWETTAGTVSYDAKTGAAFTINKQGDSPTLRTKFYFFFGRTEIHLKVAPGRGIVSSMMWLSDDLDEVDWEFLGSNKTFATTNYFGKGRQDFKNGGSHPMTGMQDDYHNYTTVWTKDSIEWFIDGNHVRTLNSKDANNTHNYPQTPMRMSVGIWAGGDPSLPEGTRLWAGGDTDYANGPYTMYLKSAQVTDYSSGKEYTYGDRSGSWESIKIESGNSTAVDALNKQPDKSTSEKWNDLPTGAKAGVYAGGGAVGALALGALLWYYIRQRRIGAAEAKAAALRDEEDHRENARFLKDGINPDGFTDHGQEYNARELRAGGMASENSYHVPESSPFDGPFDEKSRLGSSASNVSTLVGAAGAGAVAGGAMGAAGAMRGQPGRKASPASSNHGFDFGVPPSPGHPSRSPSPGMPPGSPRQHQMRSGSAPDPYSRMGSPGPHQQGYGLQRMQSPGAMGPQRSFTDNQQPGYGYRGPASSGGNNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YP12</accession>
    <name>A0A7D5YP12_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g036010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
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            <end position="503"/>
        </location>
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            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="569" mass="63495" checksum="8DBE0DAAF5854A7B" modified="2021-02-10" version="1">MFLHSGASLHGHEYSIKRSTSAPVQPPRRLPILKSTLRPLVSPSESSETGYFASPYSEGLHAPLRASTDEANQRPSLLSQQRAASNSYTRKDLAVRFREPGMDHIYTPSASEDEESIAGPEPLDGLSDSPARRKKRRRLLRKSTRYALAQPAPQLRTKQRRLLQIRPRLLLQLQEIGDRRAIPAFDLIPSQLVAGTLIIPKLSKTFPRMFHANAELSQNDVLLVRSEDYASTSGMAPERSDDDRRSLHGRDICAVISALPEDSENSAEIVLEDGVPWYASPMANGSYEFTRTDDGGEITTARWVRRFNGSTRNSIGSFEPSSSARSSVHDSLPDSRWTFSIIDPSSRRHPIMGSLTSETVEVYDHYTTLSTSSGRFPPTRSFVPEAEGVDRSPSPAGFNPESRATLEVLPEQKALMIATASWIRLHQQGWPASANPKFARSIPSHCRSASANMCSTSRRRTFPSYDGDSSRATSPINLSQPSDSLHDPSLSKHPHGKSMPARAMSTGRAFMKRRSDRMEGLATVYSQEPPRPVYDAEKLDTLPEEKVGCLSRIRQWTHKLFHRRRDSIR</sequence>
</entry>
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    <accession>A0A7D5YQL9</accession>
    <name>A0A7D5YQL9_9HYPO</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="mbrn:90967420"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI65902.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6740" checksum="13024CA187C2BF3B" modified="2021-02-10" version="1">MSPDSKTEDTKIKDRDVSDDDAQPIDPEFLFVKKPTTTSTMTDDAEGEDEERKMEQSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTS5</accession>
    <name>A0A7D5YTS5_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">N-methyltransferase vrtF</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">vrtF</name>
        <name evidence="3" type="ORF">G6M90_00g056750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTS5"/>
    <dbReference type="GeneID" id="26242677"/>
    <dbReference type="KEGG" id="mbrn:26242677"/>
    <dbReference type="OrthoDB" id="10061782at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
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        <property type="entry name" value="MeTrfase_VrtF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mtase_YbcY_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="229" mass="25820" checksum="4884DBCC15AD18BC" modified="2021-02-10" version="1">MSASGSASSGDDKAAELYKTRRLLLYDYWVLGIVSTYAWGCPTSQYPLPQFRANVGKNHLDIGIGTGYYLRKGRIPPTTKITLLDIEKTALEFALKRCGRSDARAIVADILKPLPVDDKFDSISMYYLLHCIPATVEEKCNIFSHIKNNMTPDGVIHGANVVARGVRKDNRFAAHMRRKVVEAGIFQNKEDNPYDFEHALRQNFHEVEVRVVGTVFMFRAAKPKLDEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTX8</accession>
    <name>A0A7D5YTX8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g062070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542668.1">
        <property type="nucleotide sequence ID" value="XM_014687182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTX8"/>
    <dbReference type="GeneID" id="26244617"/>
    <dbReference type="KEGG" id="mbrn:26244617"/>
    <dbReference type="OrthoDB" id="4961113at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="55588" checksum="916E5E23D127FF82" modified="2021-02-10" version="1">MPGFQLDSKTYSHHPTHAVDESESPSSNPVEYKRRGIFSPSEWLLEMLSTIGSLVCLAAIITIFWNMDNKPLSAWNSIVSLNAAISILTTAHGAALMHGVGNFIGQIKWLHFKEGVDKLENLQKFDEASRGPWGSFMFLATVKPNLATLGALIAIARFALSPLTQQVVKIEQQLVPKGNAVFGYAHEYNRGLILANNVPDSIPQDPGLQVAILRGLYNISSPEVFSCSGECRWEGRYISLGFKTECTNVTRATLDTSQCAKAYYDNPSLTLCNMTTPSGLGISTRYAETDLTTTYCMNFSSRWESDDELRTRLPEIARFALYRSTSDGNFNAWDVNITDCSLSLAAYEYTNARANGSAFSLKQTREVEPNPKNPWDYITDDDGMKSPARVQLNTSKVQGTPALAISLSDLSALSVYLESDSIASELVSGNWVNKNSGLSAALSGNVDVGKRFEMMALSMTSYLRSGPNSIPAAGTSFSSQPFVSARWPYLIGPGIIQSAALYLFWGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTZ4</accession>
    <name>A0A7D5YTZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g060940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542774.1">
        <property type="nucleotide sequence ID" value="XM_014687288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTZ4"/>
    <dbReference type="GeneID" id="26244723"/>
    <dbReference type="KEGG" id="mbrn:26244723"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000136">
        <property type="entry name" value="LGO_GLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="10">
        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="520" mass="58396" checksum="E423665D9CBE957C" modified="2021-02-10" version="1">MHPAAESELRGQNADGVAFRAKPHHVHRTWARTFSSIPELYIQPETLAEVEKVVSLAQTCRRRIVTTGCGHSPSDITCTSSWMVNLDRFNKILAVSTDTGLVTMESGIRLYALCEELERHGLAMPNLGSINQQSIAGAISTGTHGSSVRHGLMSEDVQSLRITLANGTTKLCSAESNPELFRAALLSLGALGIITEVTLRAVPAFKLKWTQTIDTDYKLFKRWPLDLWTQSEFVRVWWFPYTRRAVVWQADKTAEPEQDPPASYYDGSLGYYVYHNLLYLAQFAPRILPWVEWFVFGMQYGFANGSATTAVQPSRRALLMNCLYSQFVNEWAIPLHRGPEALRRLGAWLNRLTPDDPDYVAHGIPFSADGLYVHAPVEVRVSDTSLTSSLRPYLDPTVPDGPTLYLNATLYRPYWRDPPCRDRYYQAFEWLMRDMGGRPHWAKNFETCRPDIEAMYGESLAAFRGIRDGVDPEGMFVGPWHRERIMAPLPGPKLPLEEVEVSRRKAAGGGLVMEGLVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVE8</accession>
    <name>A0A7D5YVE8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g041920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986270.1">
        <property type="nucleotide sequence ID" value="XM_066130290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVE8"/>
    <dbReference type="GeneID" id="90967674"/>
    <dbReference type="KEGG" id="mbrn:90967674"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="99" mass="10243" checksum="01E3957C0988CD59" modified="2021-02-10" version="1">MALDLNADIDAAEGVSKQEALGTTRVIDAAEDSEQQAEIQHQPDARTKPGTLKLGRGLRAARAVEAVAPLYAGLDGGFNNCTGGSIILLPVEKTPDAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVJ1</accession>
    <name>A0A7D5YVJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986294.1">
        <property type="nucleotide sequence ID" value="XM_066130340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVJ1"/>
    <dbReference type="GeneID" id="90967683"/>
    <dbReference type="KEGG" id="mbrn:90967683"/>
    <dbReference type="OrthoDB" id="4835952at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028813741" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="65" mass="6994" checksum="CD97A7DCA0C771F5" modified="2021-02-10" version="1">MKFFAVTLLALATAVMAAPSVKERDIFIRQEFVVDTETPSMTDAQGNVVPFDASNVNLANTNAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVR4</accession>
    <name>A0A7D5YVR4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxypropionyl-coenzyme A dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HPCD</name>
        <name evidence="2" type="ORF">G6M90_00g104800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541472.1">
        <property type="nucleotide sequence ID" value="XM_014685986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVR4"/>
    <dbReference type="GeneID" id="26245722"/>
    <dbReference type="KEGG" id="mbrn:26245722"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006108">
        <property type="entry name" value="PRK08259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43802:SF1">
        <property type="entry name" value="IP11341P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="279" mass="29759" checksum="BA067CA957E77227" modified="2021-02-10" version="1">MATDKPQAVQINKTEHGITTITINRFHRRNAIDGPTAKELTDAFLAFEADPTQKVCVFHGANGTFCAGFDLHEVAKYHSTESSSGAAGYKGPIIDANHRVQGRNIGPIGPSRMQILKPVICAVAGHAVAGGLELSLLGDMRVAEEDAVFGVFCRRFGVPLIDGGTVRLQAIVGLGRALDMILTGRPVSAQEALQMGLANRVVPRGQSLQEATKIAEQLLAFPQECMNVDRANCYYAAYNATSFEDGLRNEFDEGVGVITTESVRGAARFAAGAGRHGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVU8</accession>
    <name>A0A7D5YVU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagB</name>
        <name evidence="9" type="ORF">G6M90_00g038690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547225.1">
        <property type="nucleotide sequence ID" value="XM_014691739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVU8"/>
    <dbReference type="GeneID" id="26239788"/>
    <dbReference type="KEGG" id="mbrn:26239788"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="359" mass="39563" checksum="29616083CDABD113" modified="2021-02-10" version="1">MRLIIRDDATSASTYVANYIVDRIKAFNPTAENPFVLGLPTGSSPLGVYKILVEKFKAGEISFEHVVTFNMDEYVGIPRDHAESYHSFMWKNFFSHVNVHPSNVHILNGNAENLEAECVAYEDAIKAVGGIDLFLAGIGEDGHVAFNEPGSSLASRTRVKTLAYDTILANSRFFGNDINKVPRMALTVGVQTVLEAREVVVIILGQRKSLALQRCIEQGVNHMWTLSSLQLHPHPMIVVDEDATLELQVKTVKYFKSIEKVAKEAGFEQILPSKVRTGNGVVPTTRVKEVDSPTILAPQPTTSRLLRATPATEYPVRSVSPELVPDRMASRIPEPALNKRLTPNPEQQQAALPQNAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXP5</accession>
    <name>A0A7D5YXP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BIO3-BIO1</name>
        <name evidence="5" type="ORF">G6M90_00g009690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985569.1">
        <property type="nucleotide sequence ID" value="XM_066129673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXP5"/>
    <dbReference type="GeneID" id="26238989"/>
    <dbReference type="KEGG" id="mbrn:26238989"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03109">
        <property type="entry name" value="DTBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000080">
        <property type="entry name" value="Bifunctional dethiobiotin synthetase/adenosylmethionine-8-amino-7-oxononanoate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13500">
        <property type="entry name" value="AAA_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028868365" evidence="4">
        <location>
            <begin position="21"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI63426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="800" mass="88111" checksum="D2C6E0B5DDAE389F" modified="2021-02-10" version="1">MKSPLASLLWRSLRVYQVFGANTDVGKTIFTTLLARTAKKLWKDENVAFLKPVSTGPEDEADDRYDCSLNKPYLRPQVISNLIEQTSIASGRPIPSEDELLAKCRAFAAQCATRNGWLFMETAGGVHSPGPSGKTQADLYIPLRAPSLMIGDSRLGGISQTISAFESLRIRGYDVESVLLFKDDGYGNYRYLEEYFRKQHGIPVTSLLPPPKKHDNPDQDAEVMENYYRRKDLAEITGQVLETLDRNHAARIRNLDTMATRASKHIWYPFTQQSLVGPKDIMTIDSAHGDYFQTLAPPTSTSTSTSAPSPDTPVIRSSFDASASWWTQGLGHSNPKLTMAAAYAAGRYGHVMFASAIHQPAMALAETLLDGIKNPRLNRVFYSDNGSTGIEVAIKMGLRAARKRYGWDTTQKLGILGLKGSYHGDTMGAMDCAEPGIYNEKIEWYQGKGHWLDYPTVLCRDGKWSVSAPDGLQESLGPGRTYASLREIFDVAGREANGEHEAYKTYVTSTLQRLKSQGRKFGALMLEPVVLGAGGMQFVDPLFQRTLVNTVRESSHLFGESALSADEAQDPNEWTGLPVVFDEVFTGLYRLGRFTPSSFLGVHPDISVHAKLLTGGLVPLCTTLASENIFKIFLSPDKTDALLHGHSYTAHPIGCQVALESVKEMQDMENRGEWDWAKAQGWTQQHSGQSEAQIDVWSTWPREFVERLSRQTGKVAGVWALGSVLAIHLRDEAGVGYSSNAALGLRESLGLGRADGEGGPWNVHSRVLGNVLYVMASQVTSETSVRQLSELLMESLAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXZ2</accession>
    <name>A0A7D5YXZ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malonate--CoA ligase ACSF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ACSF3</name>
        <name evidence="2" type="ORF">G6M90_00g056130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544206.2">
        <property type="nucleotide sequence ID" value="XM_014688720.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXZ2"/>
    <dbReference type="GeneID" id="26242618"/>
    <dbReference type="KEGG" id="mbrn:26242618"/>
    <dbReference type="OrthoDB" id="4935020at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="560" mass="62307" checksum="1BEC3693807F7E87" modified="2021-02-10" version="1">MLLPQTALPDDPIFSRLVQLATRRDGQVIVDDRSRGTQFGYGHILHGTVDLVQKLRSLLNRDILDNRGGFYIAVLAPNSYEFIIAVLAVLALGGVVVPMPTGALASEAAHILRQCGACCILVGPEQVDLLARIEDEVKIPSLLVRSHVGDSKSKNPVPATSFALDPAAAVSEECPSILFFTSGTSGPPKGVLHARRTVSKYARLEEVGTNEEICIIPRGAFWSLYFTKLFQMLLIGVRVEIHNFGRNYDLIWEKLRDGTATRIALSPTFWYGMMDFFQRHISKLPESTIDEYVRGVRQLGDASASGAVLSNRIKEFWKDMRGGRPLKVQYGSTESQEISICDEGAGMVEGDLGVPFPNVTIKLSEGDEGELLVKTPAMFLGYLNSSDSTAQCMDSDGFFKTGDLAIRQNGRYIFKGRANMDLFKFYTYKVPRMEVESCLLALPYIEEGYIMPVADPQCDTRVAALVRLRDCFHTVDLSTIRGDLSRDLPAYQLPTVLRVLRDGETVPRTWSDKTALKQAVRMFFPQDDEERLCGEAIEVMDVSGFMKMETKKPWDLSGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY84</accession>
    <name>A0A7D5YY84_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NFX1-type zinc finger-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Znfx1_2</name>
        <name evidence="7" type="ORF">G6M90_00g017910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548742.1">
        <property type="nucleotide sequence ID" value="XM_014693256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238186"/>
    <dbReference type="KEGG" id="mbrn:26238186"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="491"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1312"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1591"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1865"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1209"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2122"/>
            <end position="2166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1245"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2139"/>
            <end position="2149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2270" mass="253730" checksum="F08AEF56A468D038" modified="2021-02-10" version="1">MASGELASGRAKKLIERFKNNIEGKSTISTNQDANHFLEATDILCRCKTPAFYVESIISSAKGVETLGSVVRSDLSTGFISSVMTMLMKHLSNPMVKTINSGHFLQRILFAVLCPPTFWSAVLKHQQSTGFSVGEVETFAWLCLEIVSMKSPELDTLYGDVGALMDSQSLIRAASHPVRKLAYRIEKILKLHSIAATATTGHGPGGRHDNDFLDFRAISIYPTADEVRSMDEPFLQRLDDVFDVPRESRSATYLSWLYRLLREDMLADMRDNLAIAWGQRKGRRKPPRLGGLSLVGFGDGSKTRVNPLALQLQCEDGIVFPRSIDQRDRKTFLEGSGKSFMKNNSIGVLCRNNDIIAFGCLIRNVDLLLKKTPTVVIKFINVEALKNSLEALLHPMKGELQFHVVDTATFAYEPILQRLKEIYEIPLEDMVLDPKSATSLYQPPEKLSQLLRQLRAALDKQQEVNLSSFGHIGGSIRVSGAQLESLINGLENCVGQIQGPPGTGKSFIGALISRIILKLTNYRILVLSYTNHALDQFLEDLLDIGVSERDMVRIGSKSTTRTEPLRLETLCKQPAFRFSFEVNATIRKYKSEASDVNERLVDVGEKLATAYVDPDDILTLLEFSEDATPFWPAFQVPKQDDGFELMGKNNKPIRAGEILELWVQGQDSGVVRALLASMDPASRSVWSIPISSRTEFLNQWCSKVRHDQTQEFASLAEMSSRIQREIDSLYNESKRKVLRSKRVIGCTTTAAAMYQSIIESAQPDMVLVEEAGEILEAHIITALSSSVKQLVLIGDHKQLRPKVNNYTLTVEKGEGFNLNMSMFERLIHQGHSYTTLREQHRSHPEISHFVRRLAYEHLENNPKTLEREKVRGLKGRVIFVHHEHQEEKLADVADRQLGESKKNAFEAEMVLKMVRYLSQQGYKSKHMVVLTPYLGQLSLLRQKLSRDHDPWLNDLDSYELTRAGLMTQAAAKVNKQPLRLSTIDNYQGEESDIVIASLTRSNSSGDIGFMAAPERLVVLMSRARNCAVLFGNMHTFTKSKKGGELWGDFFQALKEKECLFDGVPVYCERHPDREALLKSANDFDQHCPDGGCSEPCGKPLSCGKHACDLRCHRAIDHSQFPCNKRVSHTCVRGHKSKILCSTKVEGCKSCAREDEEIRRRAAQDLKLEIMRQEKQAAYASELQKIGDEIDHYERVLAYKREEQTQQAQLEEKKAKLKGLKAAQERREAVESSKKAQARKDQPRTGNSKNSGSKLKSQAQQEWEWMKEHGEPSNEALNKLMDLIGLETVKEEFLAVKSNIDTKIRQELSLSEERLSCSLLGNPGTGKTTVARLWAEFLACTGALPGDGFKETSGSKLANMGVSGCEKLLEDLKDNGGGVLFIDEAYQLSSGNSPGGKAVLDYLLAEVENLRGKVSFVIAGYDKQMETFFAHNPGFPSRFPIQMRFNDYSDDELLQILQRQVDRKYKGRMAIEDGPDGLYFRIAARRIGRGRGKEGFGNARAVENVLAQMGKRQSTRLRQARRSGAKPDDHFLTKEDIIGPEPSATLVNCKAWQRLNEMIGLAEVKQEVRVLLDSLTTNYQRELEEEPLMSFSLNRVFIGSPGTGKTTVAKLYGKILASLGMLSNGEVVVKTPADFIGSVLGQSEAQTKAILASTIGKVLVIDEAYGLQGAGGADGSHVADPYRTAVVDTIVAEVQNVPGEDRCVILLGYKEQMEEMFQNVNPGLSRRFAIDSPFIFQDFDDDALSRILDLKLKDGGFQATAQAKRVALDILSRERNRPNFGNAGAIDNLLSKAKGGYQKRISAGKAKRSQLEAVDFDDNFDRRSATDVEELFAGDIGREKVISLLKNIQDRFRQLKSLGMDVDEEIPFNFLFRGPPGTGKTMTARKFGKLYYDMGFLSKAEVVECSATDLIGQYVGHTGPKVHKVLNNALGKVLFIDEAYRLAGHGFAKEAVDELVDSVTKEKYKGKLIIILAGYVKDINNLLSANPGMTSRFPETIDFDPLSAEDCLKLLTSSLAKRKADIERKGKLLDLSCLQYPSEDFERNILDLFRSLSGVEGWASARDVKQLAKDIFRNVDLSSPSLKVEQDEVSEALNTMLLKRSKMEQDAAATDLSLDLANLQLREGSRPPLPSQSNISTKSQQEERTNKTDDVVSTEEPDQDKSACDGLGIRDAGVRDEVWEQLQQDWAEEQRREAEYRELKEAQKSATDENRERIVRQLIEEEKRRKEEAAMKARLMALGRCPVGYHWIKQSGGYRCAGGSHYMSDADINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYL6</accession>
    <name>A0A7D5YYL6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">scon-3_0</name>
        <name evidence="7" type="ORF">G6M90_00g013210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549200.1">
        <property type="nucleotide sequence ID" value="XM_014693714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYL6"/>
    <dbReference type="GeneID" id="26238644"/>
    <dbReference type="KEGG" id="mbrn:26238644"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="171" mass="19848" checksum="65620EBF4F4EF90D" modified="2021-02-10" version="1">MSAEDTSGAKVYLVSNDNATLQVDRVVAQRSILIKHMMEDIGYDTISQDNPIPIPNVNEAVLRKVIEWCEHHRNDPPQAQDDESDGRRRTTDIEEWDQKFMQVDQEMLFEIILAANYLDIKPLLDVGCKTVANMIKGKSPEEIRKTFNITNDFTPEEEEQIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYP3</accession>
    <name>A0A7D5YYP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g064230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540119.1">
        <property type="nucleotide sequence ID" value="XM_014684633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYP3"/>
    <dbReference type="GeneID" id="26247155"/>
    <dbReference type="KEGG" id="mbrn:26247155"/>
    <dbReference type="OrthoDB" id="5243686at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="321" mass="35161" checksum="F34BD525FC72C5AF" modified="2021-02-10" version="1">MSNSHYSSKHKHHKSSKSGRSKTTESSSNGCSWPVNGDVSFLFVVNELEIRFRDEQDLDSGIRKDDWLNVLPPNTPELYSPETLQHVSQVMRFRNGQVTPAGPAYYWARAGQFDEGCIAMAAGETQYPLQKYKSASVFSCNPSLPVVTLEGDARTNPDPDFNVLQFVHQRNADSGSNGVSLAAFSMDRSSSVCPPPVKFVAGRHASWIPSLVPGICRNPYMAGESSGLGGELPIVIGLMAFHASPDGGRTINDVFLGRGENSGLWRNYRWQSSSSPAGYTLSEQDTPRGYLVHICLDPENEAGSTLHSLYMLEWNGVLVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ47</accession>
    <name>A0A7D5YZ47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lys1_2</name>
        <name evidence="16" type="ORF">G6M90_00g044230</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986150.1">
        <property type="nucleotide sequence ID" value="XM_066130342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ47"/>
    <dbReference type="GeneID" id="26240320"/>
    <dbReference type="KEGG" id="mbrn:26240320"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="59"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI66423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="450" mass="48493" checksum="2EA46861BBB7A8DE" modified="2021-02-10" version="1">MCGTCNGDATGAAPPAANSTTDNAAPSASTSNGVYPAQGNPASSPYQSVQDYISNVGRFKIIESTLREGEQFANAFFDIDTKIKIAKALDNFGVDYIELTSPVASQASYDDCKAICQLGLKAKILTHVRCNMEDAKKAVECGVDGVDLVIGTSSFLREYSHGKSMDMIRSIALEVIDYVKSKGVEVRFSSEDSFRSNLVDILHLYQACDKAGVDRVGVADTVGGATPRMVYDLIRTLRGCVGCDIETHFHDDTGCAVANAHSALEAGATHVDTSVLGIGERNGITPLGALMARMVVTAPDYVKSKYNLKALKSLETLVADAVQVNIPFNNPVTGFCAGIHAKAILANPSTYEIIDPHDFGMTRYVSINSRITGWNAVKARIEQLGLGSEFSDDQVKEVYGSPLFSAVFHYTGDIDTMRRTAKIKQMADIRPLAIDDTDSIIRSYHLDLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ70</accession>
    <name>A0A7D5YZ70_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g111760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543692.1">
        <property type="nucleotide sequence ID" value="XM_014688206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ70"/>
    <dbReference type="GeneID" id="26243079"/>
    <dbReference type="KEGG" id="mbrn:26243079"/>
    <dbReference type="OrthoDB" id="4941282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="159" mass="17899" checksum="50D562DC18514C80" modified="2021-02-10" version="1">MEVDRYPVVSPMHPWVNPTLLNEAVIPEAEKPLVKTEASDAHALGSGSCNSLKSFNGQYYSGMVVGGSHTWNYDGGVWHEVKTEPDLWKIKLRSLHMICGRIRAGLSRRWRNSASTKKLAVRARPILLKRLLVGVMAKRLTGGICSIFLFHRVYRGRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZP9</accession>
    <name>A0A7D5YZP9_9HYPO</name>
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        <submittedName>
            <fullName evidence="9">Xylanolytic transcriptional activator xlnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xlnR</name>
        <name evidence="9" type="ORF">G6M90_00g065690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540204.1">
        <property type="nucleotide sequence ID" value="XM_014684718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZP9"/>
    <dbReference type="GeneID" id="26247013"/>
    <dbReference type="KEGG" id="mbrn:26247013"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="412"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="800" mass="88495" checksum="1CC9A8EA977FFA2A" modified="2021-02-10" version="1">MDDSVTDVYIYLVEDYGYVCRYNREIKKRGRLPASTSVRFQSESQRPVPPTGTPDDGRASQSSPPSASPAGESAVADRQPLSLSSQADQRGGSPASNIPPIVDGRLVSHAESVISHGNESPERRRRVSTSMSVTSLIQPGSHKNATSDSRAFRPRAGSLSAAFSDNHVADSEALISDDSVGYPSPANLGRPHEYRRTQDHRDSFRSAASNGDSTRESFSTATVPNSLSPDLLQKAPTEDCCYRFLDPVLPYIRNILPASVACELLDIFLTDPGSSLFRGASPYILTRIFRRKSILHPTSPRHTTPALLATILWCVAQTADVMLLHVPGTRAKVVNDLYDLAISLVSERDPDRWHRIHGGLRAEKEVPIPGWANSASVPTTTAANEPAGGVDDVLTFILLSIAVSGGDFKSDCYKWWSKALRLTLSLQLNREDERCPASVSPCANPLCSCHRDRSDATFAEFERREERRRVFWLLYSLDRHLSLSFNTVLSMPDSYCEVYAPLPERIWENLDAIPPRELPTRVMGPPVLATGTGYLEYFLPLMAILGDIIEIHHRRRHPRLGQQDDAYSISVVQHLLTDYEFSLGALGRDAAIVPASTAFQIPGQGGRDLLSGMPAPGFKMSSSSSYQADQSKVRLVMAYSTHILHVLHVLLHGKWDAISMLDGGDDWITSEHFTECASHAISASQSVSTILTIDPELTFMSYLFGIYLLQGSFILLLFADRMPQLGPNESVEQACENIIRAHEVCVVTLNTEFQKNFRKVVRSTLYSVRGTGTTDWEEHRARRRALSLYRWTKGAKGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z078</accession>
    <name>A0A7D5Z078_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g110530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543806.1">
        <property type="nucleotide sequence ID" value="XM_014688320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z078"/>
    <dbReference type="GeneID" id="26243193"/>
    <dbReference type="KEGG" id="mbrn:26243193"/>
    <dbReference type="OrthoDB" id="5032844at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="596" mass="65849" checksum="7DC45BC84E3002A2" modified="2021-02-10" version="1">MFPYQGQPHQTHDDANVRPLTDDDQQQLLRLVQRYGIPSLLCALTGSPSSSGASTFSASTLLSSISAPSLAWTGSDVSHCRSDDASINTQYTWPDVSHDMQPMHDPEPTKLSERSWLDSPAADPVPLPPNDVTSHPSPPLVAPTSKKYQCPMCFLDNSPVGFGRKSDFKKHLHNFHGADVIWICRTKGCHLSFSTERAYSTHAKEAHRVKALPNSTARTELCTQLVFSCGFAACKDRLFESQSAEDASATRDKHFEHIAKHFEDGFDVKDWEYKVLIQNLMRQPQVKSTWKTCIWPKEKRQGLHWRPRSSGDLKRMLECRHLGNDISNLVRLAFILGTAPFTSPVTPPPAEIDIYFQLPYRNQCLINSPGHNVGNTASPKPDDDTSSILTTTKRRSSRSSISQSVFRLPSRKGKRSSRPPTPASVVGPSSTPAGSAASFTSVPVSGPNGNVDTVMGDDLPNGPHPGTPYPIPNESAWPVDAPQFAPEVQQDLPKQINTPVDGPMMYAMQMEQNPHQSWCTMESFDPYPPHVGIPHGLYDYTMNASQTSTVRPATPVPHKRPASWNRVVSMESLRPAKKAIPHESIPPEMVPTMLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Z6</accession>
    <name>A0A7D5Z0Z6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorting nexin-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">snx12</name>
        <name evidence="8" type="ORF">G6M90_00g036880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986504.1">
        <property type="nucleotide sequence ID" value="XM_066130191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Z6"/>
    <dbReference type="GeneID" id="90967624"/>
    <dbReference type="KEGG" id="mbrn:90967624"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="7">
        <location>
            <begin position="99"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="416"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="872"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="562"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="836"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1223" mass="137565" checksum="2AABFCAFD64F0017" modified="2021-02-10" version="1">MALKQRDVAIAAVAAFVAWGYAVSWFSVLRWAGYAFVAGILVSIIGLVATLLLTAQRPQRKPYQLPRASFLGAGRWKKEVSALRKRQAYEKQRLELGCSPHVLDAVDGLLDLILRDFVCSWYSHISRNQVFPNEVDRAVRLAITNLLESLRHKDLAEIVTSRLIPILTAHFRDFYDAEKSVRGRKLNRSVTESEELDLAIASKYKDGNLHPAASLSFPDTKMVQQDYLRSLVERIVPKMLPEKMLASRSVSIIIREIVSCAVLSPVLQLLSDPDTWNQVMESYGRTMLQDRSTVRKLRAALDQHASPTPRTVKMAPAPRLAPGDSERKFEKFIRAIRKVNNLSDARRFRSEVASQLKRDSLQVNQDPAYLRRLEMGKRLLDQRVQHLAAGGDRLPISFNPAPAPAAAVTSKLENVSLVELLRDASGLSYFMEYMDRQRLMSLVQFWLVVDGFRNPLEDDGQEDEAVSSNLSMWSESDRMDLQQINRAYLSKPELHVPDSSRREVRQFLEAGKSATPLQYHRARKSILKAQSAVLEEMQSQHYHGFKKSDLYYKCLASQESSTASLAPPPLPPTHPPTTRASQSYQAKPKPVSRLATSASSYTTRRSDSASDLRGMDGNSNGPDPLTQSRRSLDEPGSAPLFDDEDVDNDGLMDSVHSAGEPEPPLQVTPDTHIVQAVEEALNNIMDDDRPQTAEDLRASLFGDAEDAEGSLLTSNDRESNRDSIDSGRPIIAAKDQEKPSLSSLGLVSAASRIGVFVDDDLFGDEDKFLADEVEDAEEGNTDKDEDEEVHEAAPGDLGLAEAISALTNDIDRLVAQEAIVDSLTRKAELTNNTSELRILRKSKASLQREIRRKELQRQQYVVQESDNSLYGRSSVKIKSIQVGREDDGREFAMYVVEVQRNAGEQMPAASWIVTRRYSEFHDLHQKLRSRYPSVRNLDFPRRRVVMKFQSEFLRKRREALEKYLRELLLLPEVCRSRELRAFLSQSVITPGQDILDREDKKDIVSRLYDSVADGMDDILGNIPVLDQISVAGQNLIAAATNQLNAMPLNVNEEAFPAAEAEAELNAFENKELEPFIKPICDIFLEVFELNRGNNWLRGRAVVVVLQQLLGGTIERKVRDIVKMLLQDESILRYIALVEDSMWPNGVLQRDRKPRSEAQKKQTRREASLMLATLVPDLAGNVVGRANAQTASRRIFATLNNSRLNAHLVFTMLEEIISIMFEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z228</accession>
    <name>A0A7D5Z228_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cut3</name>
        <name evidence="15" type="ORF">G6M90_00g044920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547821.1">
        <property type="nucleotide sequence ID" value="XM_014692335.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240384"/>
    <dbReference type="KEGG" id="mbrn:26240384"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="746"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1181"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1471"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="421"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="625"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="898"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1257"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1196"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1486"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI66746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1495" mass="167373" checksum="3952002A4C5097CF" modified="2021-02-10" version="1">MSAAAPTRPSRRAAMRRAAIIDSDDEDEIGNTTKIRADDEAEYTPEASRTTRRQTRGGRLSVAPGSAPTRRRSRVKKQSIASTEPDELEGGPDSSHAVDADTTIQQTAQTPPKKPSPRKRKSAAPRASIAPTEDLAPPVPKQPEPFEGPQAHGSPLADITAVSVNAAQNVEETQANVKPIKPFDSIMDKPLDIILKSRTTTIPFVEEPSTSPKSRIVLTHLILNNFKSYAGRQEVGPFHASFSSVVGPNGSGKSNVIDSLLFVFGFRASKMRQGKISALIHNSAQHPNLEYCEVEVHFQEVIDKPTGHEIIPNSKLIISRKAFRNNTSKYYINGKESNFTTVTTLLKNHGVDLDHKRFLILQGEVESIAQMKSKAANEHEDGLLEYLEDIIGTSKYKTPIEESAAEVETLNDVCMEKSGRVQHVEKERNSLEDKKDKALAYIRDENELTMKQSALYQLFIHECNDNITVTEEAVNQMQAQLDAELEKHQGSEQFIKDLEKQYTKGTKEVETQEKQTQSLVKELAKFEQERVKFDEKRKFLVEKQKKLEKTINNAQNATNEADETIEETKQDIETRTQEVADLESQVKIEEAELANIRESLKGKTQAFSDKIAAKQKTLEPWMEKINQKQSAIAVAESEMNILKEKANAGAVAIEELEGKITTIETDKAAKAKELKACEKEKSELQKEAEKMNSELAILAQQEPKIQAKISNSRQKADEARSSLASTQARGNVLTALMRMKESGRIDGFHGRLGNLGTIDQKYDVAVSTACSALDNFVTESVESGQQCIEYLRKNNLGRGNFICLDKLRSRDMSPIQTPENAPRLFDLVKSKDKFRPAFYHAMQDTLVANDLAQANRIAYGAKRWRVVTLAGELIDKSGTMSGGGTTVKKGLMSSKIVADISKEHVAKLEEDRDQWETKFQEFQEYQRECEGKLKDLNEKIPQLETKMQKLGLEIESATRNLSDVKKRIKEVSQEHQPSTSDSSRVAALEREVAKLNGEIEQLRGETASVEEEIKALQEKIMEAGGEKLRSQRAKVDDLKEQINSHNEETSNAEVRRVKAEKQKVKLGKDMAKANKELENAVRELENLEADVNNQGEKSDDLKAQVKEAEADLASKREELRAFKKELDAKTAELNTSRAVEIEMRNKLEENQKTLAENEKRHRYWEDKLSKLVLQNVEDLVGAPSPTEQAAKAEQPEKEEDSSTSNEDIEMAESEAEEAEDASMADASTTEKSTEGGSNNPPYELPRYTPDELADMSKETLKGEIAALEEKTQNASVDLGVLAEYRRRVEEHAARSSDLQAAINQRDAAKKRCDDLRRRRLEGFMEGFSAISLRLKEMYQMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNIGNLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAARLVGVYKVNHMTKSVTIENKDYIDRPQPQPQQRPQPGTGFTTTLALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z262</accession>
    <name>A0A7D5Z262_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547802.1">
        <property type="nucleotide sequence ID" value="XM_014692316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z262"/>
    <dbReference type="GeneID" id="26240365"/>
    <dbReference type="KEGG" id="mbrn:26240365"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21813" checksum="42EFD06CB1F4C0AC" modified="2021-02-10" version="1">MKSRLTSTLGGSSIVYERRAVSQIRTYNWPPLQLNFWIFVMLLSASSIVGVFSSFIQIQTQLDLPIPWYFPYFITVGSVAILFMGFIFWLIATRRLLPAIVMIGAFMLFVLWLVGLVIVSVQLWGPSGSIQSTCNLQVFNRSPHGLNQETLAWMQQKNICQCWHLVFAMSLTGIVFLVWVMIMAYQVFVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2H1</accession>
    <name>A0A7D5Z2H1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prp 4 CRoW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g022980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548257.1">
        <property type="nucleotide sequence ID" value="XM_014692771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2H1"/>
    <dbReference type="GeneID" id="26237701"/>
    <dbReference type="KEGG" id="mbrn:26237701"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028906850" description="Prp 4 CRoW domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="25363" checksum="C3CACDECB6952FCC" modified="2021-02-10" version="1">MLFQTVASIALLATGAVAVEARQPYRLAVMALPGQSLMRRDTSGYKPDQKQCKAGNTCAESCGADYQQCAGGNPDVAHCFNPKAGESCCTDDSGNSCQDGYYCTHDTKAQTWCCPKDMDLTACAAAYTISGLVAATSKPPPSTTSQAPTTTSIPPTTTSSSIASSTTSSTPVITTSENTNTTTSISTASIGKSTAWTAVNSTISTHVPTQPSAGIPSVTGAPPPAPTNVNAATASGVSALLLVAAGLLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2P6</accession>
    <name>A0A7D5Z2P6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ENV7</name>
        <name evidence="13" type="ORF">G6M90_00g012300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549292.1">
        <property type="nucleotide sequence ID" value="XM_014693806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2P6"/>
    <dbReference type="GeneID" id="26238736"/>
    <dbReference type="KEGG" id="mbrn:26238736"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="45692" checksum="CE49EF2F7B38A880" modified="2021-02-10" version="1">MAQFVLDLFYSLGNCLNCFPGSPTLKINSRSFKILRLLGEGGFSYVYLVEDTATHELFALKKIRCPFGAESVQQAMREVDAYRLFAHIPTIISAVDHAVATERGSDEATKTVYVLLPYYRRGNLQDMINANLVNRGSFPERHLMTLFLGVCKALRSMHEYQAPPAERMEMGNEEDAPGANSRRGTGSKMGTRGKRTEADEEEDQERPLMESENRVSAGGKVRSYAHRDIKPGNIMIDDSGSTPILMDLGSVAPSPIPVTSQSVALQIQDTAAEHSTMPYRAPELFDVHTGSVIDTKTDIWSLGCTLYACLVGKSPFEMRSDETGGTLSLCVLGGDWRFPDETPGGAKRVNSISQAKARAASGDHSAASASENTNPTISEPVRNIVRQCLKVEPAERPGIGELITMVEGVIEDLPDEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2S0</accession>
    <name>A0A7D5Z2S0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g079330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987128.1">
        <property type="nucleotide sequence ID" value="XM_066131125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2S0"/>
    <dbReference type="GeneID" id="90968023"/>
    <dbReference type="KEGG" id="mbrn:90968023"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11001" checksum="F7070776DD66816A" modified="2021-02-10" version="1">MNELFNPAGVKPRGGSPGLVVTEALKVMMDAFHQDTAQVTPGYAAGGASKTPAHQTRRPSWAEVGFTANESGIIWGLPRDSHVGMVVEKLSLRNFADIDLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2V5</accession>
    <name>A0A7D5Z2V5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g078850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">4556</strain>
        </source>
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</entry>
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    <name>A0A7D5Z391_9HYPO</name>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3I2</accession>
    <name>A0A7D5Z3I2_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">Histone deacetylase HOS3</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">HOS3</name>
        <name evidence="3" type="ORF">G6M90_00g046540</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDACs"/>
    </dbReference>
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        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
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        </source>
    </evidence>
    <sequence length="1517" mass="163608" checksum="A89CADD85D4AE939" modified="2021-02-10" version="1">MSQHAPRRGLASSSEAYSNPDIDADARTGAHADTRPEAGQRWDLHTPHASQILSSPRSQPSFDDNPTSPSTGRLINVPSLSALGSLPHPGQRSPRPPVPSPLSTASNVATSPLSTNPPEPAVSATQQGFQPIGTRSAVKTTSRASVGPTTFYSDSSSPSSPEDEIPRLNFSNLPNDHRSVSDSVTSKPALGPAKVGRPVMAATMASTPNDVTKGLPRNSSIDTAISAISSKQAASSGKGGLQDAPSSPDIASLIKTAGSPEAVIQYLLKEKSSQSQQNSQLWRLVDKQRGMILGLNKDLEAALKEKEKYRRKLKEIMANPAVMQAASGQLVESPGLDSYRGSMSPRSPRPHPRVQTNGPPDSPSLDSDSQKGSPIDVPMAPYPITPPADKPHISPTAVSEMLDPKPAMPKPQEYATGKFDHEAEYKAADRIWKETSEEQLREIPYNASLPPSRSYASEPPKVPPPKIPTAAPSVTVAEPPSSPQPDQGLSQFPSPPRKPPPAPLQLKQHVRRNLAPAAGDDSDSDYDGILEVDEMVAESRGRRKTREDDEKERQAIAFRHAQESSASKPSPESPIKSPGQLASSTSQSKAHVQEKSHSISGLLLAAEDIVVPLQSPGLPATPRPFGNIPHSASAPVSARLAGASGPLPSRPPRQPIIMPPNTPLMSPPPTSSTGSSSGTQLNAGKCSDEPSQPSPTERTKIYKGLVTEEYPNLLLPPNALPSIKVKVASSRMKPSRASLMSLTQLEEDPVFTLAVISRADCSELWRVEKDIASLSKLDSRLKQCSACTAKTPDRALFTGHAPAKLDARRAALEEYMVEVLDTPFDTATAVEMCKYLSTNTLPPNADETGSSFRPTPESSVLKIGADGRPLRSGYLTKKGKNFGGWKARFFVLDGPEPEFKYYETPGGAHLGTIRLRNAQIGKQSHTQTHENQSPAQPTAGEDLDNQFRHAFLIMEPKKRDSSAYVKHILCAESDKERDLWVDVLLQWIDYQDVDDDKQPPRQGAKTPHDQPSSGPDHASTGKSKKSAPSKSQHKHANSDTLIGVRYDSTHAGEAPQKGSTGLPEQSSSHNLAGETMSSQANKLISAPKDPHIISDSSVWGNRAGLGAPTHDEKKQRKRSFFGFGTKTRTSSDGQDSLFGGSDAGSSSAVPPSYGHQGPVRQVFGAPLAEAVRYNPPVDVNVPLPSVVYRCIQYLDHHTAVDEEGIFRLSGSNAVIKQLRERFNTNGDVNLVADEQYHDIHAVASLLKLYLRELPTAILTTDLHVPFLHTTEIPDLNEKVAKMNELAQRLPRANATLLKYLIAFLIRVIKNSKVNKMTVRNVGIVFSPTLNIPAQVFAMFLQNYEGIFGIEPEEYELPSSTTDSESNGQAGAPPQRLEPTRPSTSSGGSASPHPQQRMDRRREHSRSTPTPPLMSHVQVARSTPTPPLVLHGGASRPAYESGYGLPNGFDGHGYHPAARTAPGYDRPIYPSASEEHGVNEPQQSIKSRRRESLVYVGGVSGLQNHGSKSRLREEGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z488</accession>
    <name>A0A7D5Z488_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Repressor of filamentous growth 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RFG1</name>
        <name evidence="7" type="ORF">G6M90_00g049190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545028.1">
        <property type="nucleotide sequence ID" value="XM_014689542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z488"/>
    <dbReference type="GeneID" id="26242369"/>
    <dbReference type="KEGG" id="mbrn:26242369"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="680" mass="74335" checksum="013491EB40DE6515" modified="2021-02-10" version="1">MTEVLSFATRDMETVSASLHPHISLQRPFRNSGGFTLASDGRQSPSPFRSGSGRKRASAINTADANHGMFEPLNVGASSQDGPRDIICLCTPAPKIPRPRNAFILYRQHHQSQVTAENPKLSNPEISKIIGDKWKHESEDVKDNWKKLAEEEKQRHQHQYPNYRYQPRRSAKNQSTWTSTSPSDEHGRCPKCHGRSISTPRTPSTPYSTSPAGNFTLASQPQPGLRRPDTAALSRRSSFEQSPTSGLPFTHQLPPVRDVEKSEPSSPEIKRRRANGVGGYHVIAGTAGAYTTRPPAPPDLSRTLPEGTTGRVRHYVGTTLPDLASLPRSQSGPMPPPLRPPGSYNEPLGRRHSGFDESLRLPPLQTSIPPSPSRSPGVESRHADIPSARLNVSPTRKPHSISQETMAMKKPNLSQKLGILSTITRVLPPEGQHGPHRDRRGVFIAVEGNASKGLLDEVGVSIEKALAAGGDVALKVWSNEAGLAEGRSTKTSAETDQGNDGAAVDSLLSEYFDTILSWRQKSKQIAYHVTGGRAGGTIQDQDQEKDSKVVQAPLTEVCTPPDDGRRPTAAPKMPVALVKGGFSLTISDKYASAMTMSDRYSPVDHWQWTASLWRGTANPDLVVHIQESQDDAAKPGVVDISRNMGLISVRVLTGQGLDEATERRMAFEVMEWMREAFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4C0</accession>
    <name>A0A7D5Z4C0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase iota</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">POLI</name>
        <name evidence="5" type="ORF">G6M90_00g049900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545097.1">
        <property type="nucleotide sequence ID" value="XM_014689611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4C0"/>
    <dbReference type="GeneID" id="26242438"/>
    <dbReference type="KEGG" id="mbrn:26242438"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="558" mass="62117" checksum="266A918962AD1F38" modified="2021-02-10" version="1">MEQQSKRVPRQKHDRVILQFDYDCFYAQVFENKNPALKSRALGVKQKNILATCNYNARGLGVKKLMLISEAKKICKDLVLVDGEDLTPFRDVSKILFNFLRSHSWNNRVERLGFDEVFMDVTDVVDYNIECLNAGCLSHSFFHLSKTDPQDGFKCNFTAIAGCVEGTVPDEAPLENKTYLRLLLGSHLANHLRTKMEEDYGYTSTCGISTNKLLSKLVGSRNKPRNQTTLMALNEQDVIAFMDSHKTRQIPGLGFKTSMQLESQVLGEEVDADSHSFTSAVYARDVRLHPSISPGFIETLLAGPGAERGVGVRVWGLLHGIDQTQVKEAGDIPSQISIEDTYKGLETMTQITEELHKLSCSLIRRMRIDLLALEHNAEKPGTQRWIARPKTLRLAIRSWPTRQGRSSASNFSRISRSGPLPGLVFDASADIDALAQKLVAEALLPLLRRLETAKGHKWNLQLINICVANMVVGAGDDKQGSGRDISVMFRRQDEVLRPFKLEPLSDDEAPSEVSTGDAEGLGSGVDWNGSDNSVCQDCGHSLPSFAMPAHLRYHEMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4K4</accession>
    <name>A0A7D5Z4K4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lxr1_1</name>
        <name evidence="3" type="ORF">G6M90_00g052050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539399.1">
        <property type="nucleotide sequence ID" value="XM_014683913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4K4"/>
    <dbReference type="GeneID" id="26247799"/>
    <dbReference type="KEGG" id="mbrn:26247799"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="167" mass="18154" checksum="81C4B7E873CE992E" modified="2021-02-10" version="1">MPLNVPAAHRFLDLLSLKGKVVVVTGASGPQGIGIEAARGCAEMGANIAMTYTSRKEEADANIANLVTNHDVEAKVCRCDISDYASVEQLIRHVIWDFGKVDAFFANAGAVHHSTMLDASKQDWDRIINLNLNGTAYCAQVIGPHFRKQGHGSFVINASIAHRIWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z500</accession>
    <name>A0A7D5Z500_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sin4</name>
        <name evidence="9" type="synonym">MED16</name>
        <name evidence="12" type="ORF">G6M90_00g100520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987593.1">
        <property type="nucleotide sequence ID" value="XM_066131577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z500"/>
    <dbReference type="GeneID" id="26240719"/>
    <dbReference type="KEGG" id="mbrn:26240719"/>
    <dbReference type="OrthoDB" id="4139168at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="10">
        <location>
            <begin position="179"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="11">
        <location>
            <begin position="850"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="948" mass="105526" checksum="1BDA1DA25FA5F676" modified="2021-02-10" version="1">MPLILDNSMQVDLDNVDDLFGDDVPLSIPVRPQGKQLQQRLDELRNRGACQAVAWSKSGTIASLAPDGLTLELRFLRCHPDTGAWELSEPTTCDLVKGTPAIPLVHLEWGTTNTPDLAVIDAAGRVSLVSFAISLNHPFITRKWETDTIDDLHGIAGCYWLPVAPTNQQKPFNIMYGPANKSGNGYQYESSFVHAIGPNHPHSAKSALFCVSSGGMLKMYWSQNNGRMEETTMELESVNTSDELVTHAAFASDKKHLLAAVATSSRQLKLLKIEIQWGGPGSSSEKITMPQNARLNPALVETHIASASWLYAGPNETNYDASMAELSFLHVLPAVMDNTGSSTVPPLIMTVRSRNVGDGSFQSAQSVLDRWEAIESKQSLDSAFEQLGNRRNSVSSDPPNTIKLKKLESIVINKVVIGIQDIQYRKVLLLTMSDGSIEYRDRFTFEEIYANEDLTKVMTLRQVGWTFSDSGPCHQVAFSPTCCSMIQIGDDAKVRWNKLEYPLGDIGSSPQDPHYPATIAALSIAAASCLWHQSNCDDLLAVVQSLATRKRFLPDWISEIIRILKIQVDYSEETHHDSLMRNSPLQSCLSIMSSLGFRGETRRRSFQSKFAIISLNMRNVVILITLASNTPMNIREKMSPLDEHEVVEALAGCAKWSVDLLCWLVDCLFELMNDDNFIQRLNPQRFGELNQYLHDRNDVSLHLLLSSSSRSFVSAVCRRISLLENISNKAIEFYKRQASGDQQGGAKPPNPQLQQAYQKMQQVTSTSLIKVTEFEKLLNILASDIRQTYAQCIPGMARNRPNPPQGKQMDIAIKNTQAHFEMAMLLSGSLGSYFLPVLSKLFAKDLPAFRKLTDPAKLFFADFELLGVQDDRSSLAARKAKGVHVDIFKRTELRSGCGTSRWRRCTRCTAVMEDVFGSRPGFTFVLAQQRKCSCSGYWALLPKGKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5J4</accession>
    <name>A0A7D5Z5J4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase sirO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sirO</name>
        <name evidence="3" type="ORF">G6M90_00g055340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540876.1">
        <property type="nucleotide sequence ID" value="XM_014685390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5J4"/>
    <dbReference type="GeneID" id="26246182"/>
    <dbReference type="KEGG" id="mbrn:26246182"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="36205" checksum="4A29E7EA29E80730" modified="2021-02-10" version="1">MAAPKIYFGTVLFNADQGYKSAEDVKPWLDALLGSKDAISGVDTAVAFRECQDYLGQLNFASHFSISTKVTGGAHPMLTATKDNVIAQAKDCLNKLDVEQVDVLYLQAPDARVPFEETLAAIDGLYKEGVFKRFGISNHTGEQIEQVVQICRSKGFVVPSVFQGSYNAIARLPETQLLPVLRKHNIAFVAYSPIAGGFFAKTSQQFRDQSLQGRWNKAGLFGKLYQFQYNKPAALEALDKWHEIAKAEGISGVEMAYRWLAYNSALDASKGDGMIIGASTVEQWKRNLAAIKKGPLSAAVAAKIDALWAPLEAGSVLDNFHAVKALMGAGPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5U5</accession>
    <name>A0A7D5Z5U5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g046640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986443.1">
        <property type="nucleotide sequence ID" value="XM_066130415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5U5"/>
    <dbReference type="GeneID" id="90967726"/>
    <dbReference type="KEGG" id="mbrn:90967726"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12014" checksum="F9EE3DAF5F995E62" modified="2021-02-10" version="1">MATLTPEAIVAIVGLVIALPPTVVVIIRLLWRWNGTGAPGQQHMSNSQDEEAAMTVQPQQQPYWYAVEGDPRLRGDPCPRRISTREAMHITRYQRSEIYNMDVAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z611</accession>
    <name>A0A7D5Z611_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding monooxygenase BOA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BOA2</name>
        <name evidence="6" type="ORF">G6M90_00g093870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987537.1">
        <property type="nucleotide sequence ID" value="XM_066131465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z611"/>
    <dbReference type="GeneID" id="26246365"/>
    <dbReference type="KEGG" id="mbrn:26246365"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="534" mass="61618" checksum="DF6D289465156E0B" modified="2021-02-10" version="1">MANQERHKFCIIIGAGPGGLIQAAELLRQKVLQAKDIQILERNDDYGGVWKRATYPGAACDVFSCLYQVSWHRNPDWQCLFPSRSELIEYYKNFAKHYGLSACTSFGQHAVRVTWATEKSLWIVETKDSESRNYRRWTSRVLVQAVGTFSQKHTPAIAGLDRFKGEVWHAADWPEDYDFTNKTVAYVGTGPTLVQALPHMQAKANLVHVFCRSMAYCQPMPNFEYPLWARRAFRWTPALLRIYAFILASAFFIWLYFAYRPGSWTARLTERGCRWYLYREVSDEHLLSILTPAGRFGSKRPLVSYSGFFKALQKDNVRVINCPIVAMDEFGLIVETPRSSDSKRRIEVLERGEDHTEEIQSMDQTIHVQADVLIWGTGFKVQEWGGTVPTIGRTGETLREHWDHYPNTLYGTMTSGFPNLFFINGPNTTPPWASPIQGFELQAALNTKAIRHIHQRSLKCPIYSLEPRKEKEEAWTEAIKAHLNKLATSPSHDPTNYYLNKQGQNTFFWPWSHTYYWWKTGERHSGNECVDCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z675</accession>
    <name>A0A7D5Z675_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g075310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545566.1">
        <property type="nucleotide sequence ID" value="XM_014690080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z675"/>
    <dbReference type="GeneID" id="26241599"/>
    <dbReference type="KEGG" id="mbrn:26241599"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19143">
        <property type="entry name" value="AKR_AKR6C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="347" mass="38998" checksum="64353302D3171E85" modified="2021-02-10" version="1">MSRPEDTPPMTYRFLGRSGLQVSSISLGGWLTYGGHVDREGTFACMKAAYDCGVNFFDCAEVYSGGESEIVMGEAIKKFGWKRNDLVISTKVYWGQAFGDNIVNNKGLSRKHIVEGVNASLKRMDLEYVDIIFAHRPDRQTPMEETVRAFNHIIDTGKAFYWGTSDWNADEIAQAWRYADKLGLIGPVTEQPAYNMLQREKVETEFAHLYRENGGLGLTVWSPMRQGILSGKYKDGIPEDSRFNQTSVEFIKGFWGRTTKDTWNGIIEQVNKLQPIADKLGIKMSTLALAWVLKNPNVSTAITGASRPEQVYENCKAVAAVDKLTPEIMDEIDEVLNNKPPAIVMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7K8</accession>
    <name>A0A7D5Z7K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MACPF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g080230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987134.1">
        <property type="nucleotide sequence ID" value="XM_066131151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7K8"/>
    <dbReference type="GeneID" id="26247668"/>
    <dbReference type="KEGG" id="mbrn:26247668"/>
    <dbReference type="OrthoDB" id="2562973at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054586">
        <property type="entry name" value="MACPF_1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22693">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF-like" evidence="2">
        <location>
            <begin position="334"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="681" mass="73404" checksum="91C2BDF891579928" modified="2021-02-10" version="1">MPDAANTEASKPGLATNTQTPPPTPVTCIINVTDGVDSTVEAFFLEIHSTDVDDEKLSDLRSLIVKNTRCVELLQFPFCLASGAVVQDSMSVEYYLSKCLKIDAKGQAIEVFMKDEKLPTETGWNDFVPSYYSSPLTGTNARHVSELEEKQWGVVVETNQLCYGISTITEDVTIVEKGKKKTETRVVGVQKPKYPAFRLATRKVLSDTVASSMVKNVELDLRIPRYTNDDVSYVAFRYSTSAAQESLARQGFSQTDISASGSGGAFGCSVDASASLSVAENTSNQSSTATSKGKATMSYNFPRVTMFLDELGLELTPQCEQDLKAIQDAAGYSRFLKRYGEFFSTTVQLGGSLFASEEYETSSDSSRESTAKSLKAAAAVSLGGVGYSGSVSASHQQSSQDARGASNEESSKTLIWEANGGNTLLCNDPAAWAPSVAYYGNWRILKQGRVVRLMDLICTLEGFRYVKEQLPVWKNTGTAVESPVGQRFTLNVKACLGGKYMVGHGGSDPGKIEIGPEVEKRTGKFLAWELASADKGDVATTVEYGKDYYLMHCESHLYLTFSDIAKTARLIVSMVGTPKKDKNGPIYFISGTRTRDYTMRFYDGECKGKQGTIETGDTVTLEFKGASGSLGFLAAETSGQDKIYVTKGTDGPSVSEASDGVGEARDGFVGGAAEPEPVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7R6</accession>
    <name>A0A7D5Z7R6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">30S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsO</name>
        <name evidence="5" type="ORF">G6M90_00g071770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545882.1">
        <property type="nucleotide sequence ID" value="XM_014690396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7R6"/>
    <dbReference type="GeneID" id="26241915"/>
    <dbReference type="KEGG" id="mbrn:26241915"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="319" mass="36177" checksum="C8E78949808BB117" modified="2021-02-10" version="1">MPPRLEVLQRLGTFNLCLRPTTRAATPNFLPVIQTANLSQREKKRKAKQDPYKWAQAQQRKNANLKRREELQKQRDEAWGNPVLGKTTPFLESLDTAGQVAFSEVPRDASGNPLQTPHELPTTPGLRNHFLTDAELEEATKHAFTLSKPMAAIVGDQLSDAASNEANIEKHKQDHTKAVEALRRITSLRNGSAKDRFHANVRRLVDEFGRHKTDKFLKPKPQSISPNTTPMPDRAGPDTGSSEVQIAILTAKIRTLSKALEINRGYKDVHNKRNLRLLVHRRQKLMAYMERKERGSERWTLMIEKLGLTPATWKGQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8I9</accession>
    <name>A0A7D5Z8I9_9HYPO</name>
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        <submittedName>
            <fullName evidence="4">Epoxide hydrolase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ephB</name>
        <name evidence="4" type="ORF">G6M90_00g078430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689779.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241298"/>
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    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="49"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="413" mass="45775" checksum="8230B81D26EF9BE7" modified="2021-02-10" version="1">MDPTTLPPWRLPDGVASRFVDTSPAGLRFHILESLPAPNFEAADRRLPPLILLLHGFPNLSYDWRFVLPKLADAGYYAVAFDLRGFGRTHDADSSRISDEAIRPLAAIRDVVTLVHALGYAKIHTLVGHDLGAYMASITALMRQDMVGSLLLMAHTWKGIAATPFGNSPADALAAAVESPKMPRWEQNKDADVHTSLGRLDPPRKHYKWYNASAAASDEWTYPTGQPLRDFLRGYFHLKSGAHVQKIPPRPLASWTATELAILPHYYVMRAHQTMRENIALDMSEEPQETAAKLHLTPWLTDADVDVYEQEYARTTFRGPLLWYRVLTDPELSGDLSCLAGLKLKMPTKYVSGLGDWGTYQVPGGLEAMQQGVSVEPECWRGATLVPGAGHWVNMEKPDESAAEILKLASTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9U4</accession>
    <name>A0A7D5Z9U4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-related protein SCJ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SCJ1</name>
        <name evidence="10" type="ORF">G6M90_00g078830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689740.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028816775" evidence="7">
        <location>
            <begin position="21"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="415" mass="46744" checksum="29C7D2B5CF4D4E11" modified="2021-02-10" version="1">MLLHGFALLSLLALVQLAICAEDYYKILGVDKQATNKQLKAAYKKLAVKFHPDKRNGDEESAHQKLVELSEAYEVLSDDELRQIYDRHGHDGVKQHKNGGQGGGFHDPFDLFSRFFGGHGHYGHSSQEPRGHNVDVKIKISLRDFYNGATTEFQWNRQHICETCEGTGSADGQVDTCSVCGGHGVRIVKQQLAPGMFQQMQMRCDACGGRGKSIKHKCPVCNGQRVERKPTTVTLQVERGAGRDSKVVYENEADESPDWVAGDLVVTLAEKEPAPEDNPDKVDGAYFRRKGDDLYWTEVLSLREAWMGGWTRNITHLDSHVVRLGRTRGQVVQSGHVETIPGEGMPKWHEDGESPGHQHEFGNLYVTYEVILPDQMEKKMENDFWDLWEKWRATKGVDLHKDSGRPEPAVARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBJ8</accession>
    <name>A0A7D5ZBJ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g096880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546648.2">
        <property type="nucleotide sequence ID" value="XM_014691162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBJ8"/>
    <dbReference type="GeneID" id="26241071"/>
    <dbReference type="KEGG" id="mbrn:26241071"/>
    <dbReference type="OrthoDB" id="10519842at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="216" mass="22788" checksum="6DAD5821003A0AD0" modified="2021-02-10" version="1">MARTREEAASASADLPARRSSRASAEGVSKPEPSGRARGRPRSNKPPREPTGRPRGRPRLNKPPKEPTGRPRGRPKGSGKKAVEKKTPTKTTATRAGSRGRPRKLVGGEAAAMAKTSTPKAKNGRGRTRKSGDATLVAEVETVEEAKHAAEELEAAGEEGMDVDTPDADIRGDVEDVDDSEDAEGDDALDSPSGIASSPGEETGQQWISKIKGYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDY0</accession>
    <name>A0A7D5ZDY0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caffeine-induced death protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g110270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543832.1">
        <property type="nucleotide sequence ID" value="XM_014688346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDY0"/>
    <dbReference type="GeneID" id="26243219"/>
    <dbReference type="KEGG" id="mbrn:26243219"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22000" checksum="2CA80CDE205133A0" modified="2021-02-10" version="1">MTELPHRPSLSPQLCFSSGALRDFLRLSRSAVDDTITENLNALVTPSHPGFDPSSTSQRTPASGSRPIGSEACKSFKTAVLFPAWQARTEVLNYCALIAASPDPDDPEATLRDIEEQKNRERVVDERLDPYSSRFFLREPRTRILASLVRQERGVEEIIRNRTWSVVQERCNYSPHDTWQAAMRTCGFDDGSRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPJ7</accession>
    <name>A0A7D5UPJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g021930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985597.1">
        <property type="nucleotide sequence ID" value="XM_066129883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPJ7"/>
    <dbReference type="GeneID" id="26237802"/>
    <dbReference type="KEGG" id="mbrn:26237802"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21250" checksum="C616371D28958216" modified="2021-02-10" version="1">MAPKRPLESGDPSLEGKKPKRGFRKDLIQKAKVKKEYAKIKAREQQKDDNDDGVNSQDEAPKSQEEEPEKMHPTRELMLKDEDKAQAGAGTGASADPTSDGMRRRTRRPGYYDKQLKKAEERKTESEQRTLEIQQRREERERRLAERERFKKAMAKTIGRDGKKKLGRESTILLDKVKRIMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPY8</accession>
    <name>A0A7D5UPY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MAL11_1</name>
        <name evidence="8" type="ORF">G6M90_00g025750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548008.1">
        <property type="nucleotide sequence ID" value="XM_014692522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPY8"/>
    <dbReference type="GeneID" id="26237452"/>
    <dbReference type="KEGG" id="mbrn:26237452"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="479" mass="52505" checksum="7F7E53DEF27A736B" modified="2021-02-10" version="1">MGTKDKSDTLEAHVLGVEELSFKHETVRTYHLLEHELTIKDAFNRHPALIWWSFYWLVAGVGWGFDAQVNGGMLSVESFRRDFGYIYDREAALPADWQTAFNTVSSVGQFFGGFLCAWLADRIGRKRALFVGVAIVTAGILGEIFSTARAAFAVSKLILGFDLGFYLTLAPLATSECAPVVFRGGISTAGFRRMDIPLGIPSSLCYATLYLRFSLGLLPFAPETPWCLARVGKREEAKRSLCKLYGSGVDIDAKWVALEATIVEEEAAKYQQGSIIQCFRGTDRIRTAISTGVFACQHFVGIIFVTGYSTYFFQLAGLPPSKSFDLGVGVTACGLLGNIFSWFIVNSLGCRKIFTSGMVLMTTILFFIGILDVIHTSAAKWVQAALTAIYAFVYFTSLGAMAFTIVGEASSTSLRAPTMALATGTQAIMGIIFNFTIYYMINPDEGHLRGKVGFIFGGLATIATAWSFFYIPELKGRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQK4</accession>
    <name>A0A7D5UQK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HAT1</name>
        <name evidence="14" type="ORF">G6M90_00g015080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549017.1">
        <property type="nucleotide sequence ID" value="XM_014693531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQK4"/>
    <dbReference type="GeneID" id="26238461"/>
    <dbReference type="KEGG" id="mbrn:26238461"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="485" mass="54617" checksum="0A3FA6BD927D469C" modified="2021-02-10" version="1">MAALPDLTDWLVDSNDALNVSLVSPSKSGLRLVGSFHPSFTYPIFGDEEKIFGYKDLKISLRFRANDMRPHLETTYSKQLSPSAGVEEPTDINAVLQTGNHLPKVAFVKSSDFESSSQQLGDNWTPPGTLQETIDGPDGQYEIWKGSLEDPAIKQLNSRIQILVPMLIEGGSYIGQNPESDSSDIDLSDANRWTVFFLYRTQKSDGEPDKKSYVFVGYSTVYRFFYFGRPPTPPPESGDKWELPDGSFDLSNLPCRTRLSQFIILPPFQGKGNGATLYKSIFQHYHKHDQTHEFTVENPNEAFDDLRDVCDLTFLKTIPDFVKLKLDSSVTIPKKGPVPNLVVGGDKLEEIRLNAKIAPRQFHRVLEMYLMSQLPSSVRPSMALDDDRPAPTQADKHLERLWQLIVKQRLYRHNREALSQIEQAERIDKLQETLTGVELEYARILAAYERAAGHGLGPSQSNGKRKLDDEAGDKTPSKKARVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQQ6</accession>
    <name>A0A7D5UQQ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aes</name>
        <name evidence="4" type="ORF">G6M90_00g009850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549531.1">
        <property type="nucleotide sequence ID" value="XM_014694045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQQ6"/>
    <dbReference type="GeneID" id="26238975"/>
    <dbReference type="KEGG" id="mbrn:26238975"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="109"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="347" mass="37334" checksum="B1C7E99CB8B2493F" modified="2021-02-10" version="1">MKLPEYPYGYSQAAELDSRIRMPRPPIDPTLAPIIDSYLLPEELDLGFMRGLPSSDGDDQAPSYNAGTITDGRPHLKHTEHRVPGPDGNTVIVSAFAPKEPTSGALPAVYYMHGGGMVSGDRFAGVDELLHLLAGIECVVLSVEYRLAPETRAPGPAEDCHAGLAWASGHSSQLGIDPAAMVVVGVSGGAALAAATCLMARDRQSPATPVRAQMLLSPMLDDRCRSVSDQQFEYGSPWCGVTNRAAWAHVVGDEARGSAGVSPYQSPARERDLSRLPQTYVDVGECEVFRDPAVRFAADMWRCGSTCELHVWPGAFHLFDGMDNPGVALIRAAIASKQAWLRRIVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQU7</accession>
    <name>A0A7D5UQU7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g011760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549346.1">
        <property type="nucleotide sequence ID" value="XM_014693860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQU7"/>
    <dbReference type="GeneID" id="26238790"/>
    <dbReference type="KEGG" id="mbrn:26238790"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="131" mass="14463" checksum="A3D7C28022422006" modified="2021-02-10" version="1">MAAKDAITCHVLDTAAGRPAKSIRVRLEGPRGSQPAKEFESITDDDGRIKVWLPYSSATASGEVPVYTLDDVLGQAEASSTWTLRFDIEGYYGEGKTFFPEAVVVFRVQKGQHYHVPLLLSPYSYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQV0</accession>
    <name>A0A7D5UQV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Death-inducer obliterator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Dido1</name>
        <name evidence="9" type="ORF">G6M90_00g002710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542812.1">
        <property type="nucleotide sequence ID" value="XM_014687326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQV0"/>
    <dbReference type="GeneID" id="26244185"/>
    <dbReference type="KEGG" id="mbrn:26244185"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="435" mass="48108" checksum="24DDB8E49547A510" modified="2021-02-10" version="1">MDQRPGSSHEDRLRSESADRAVKSEHAVSSPQIAGSDLASASFKPSPTPLPSTEAPDSAAMAVASKKKGTATGVKKVPKRPGPGNSKRKKKKKTGSAAPGVDDASGEEESDNGPYCLCRGPDDHRWMICCEKCEDWFHGECINMNKEIGENLIEKFICPNCTTADLATIYKKTCALRACRKAARLAQSQPSVFCSNEHAQIWWERMISRLPKGRAKSGLNGQLAQDEFMALLSSNIGSRDEDGTLKLVKTPFSDDSTNGIEAEGDDALSKLLSDEEQQVLDEAAKARFELAEETLLCHKMFTLIELAQERRRAAITDGRFGDDICGYDSRLDAVSARDVFSAFIKSPEGEEVFKNSKLDDPLGEDDMVRGMCERKRCKTHSGWQKMLPLGVKHHIREMAGQAAEVGEEEQIVRKAVLERWKRRQAESNWVESLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQY1</accession>
    <name>A0A7D5UQY1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PAM17</name>
        <name evidence="13" type="ORF">G6M90_00g019540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548587.1">
        <property type="nucleotide sequence ID" value="XM_014693101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQY1"/>
    <dbReference type="GeneID" id="26238031"/>
    <dbReference type="KEGG" id="mbrn:26238031"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="267" mass="28672" checksum="009256BBD88BD5EC" modified="2021-02-10" version="1">MSSSLKSLALRVPRATSCKSPTAIIRCCSKASMSTATRPAGLTNAAPSQPSSYAMSMKLHSYSLAASSKSVLRLVPRARTTSPMTITSQARCFASAASSMSSSGTSSGAGAAASKSTLDWDSFFKLRLRRRRIQLFFSVTTGLLGGAGGAILLSTGMAEPVVMQIPLDPFVTLGLMTLACAAMGWLVGPSIGNQVFYLLNHRLKAQMMSKETEFFARVKKNRVDPTNSSAGNPVPDFYGEKIQSVSGYRQWLKDQRAFNKKKTRAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URE0</accession>
    <name>A0A7D5URE0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">BZIP transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g006570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549850.1">
        <property type="nucleotide sequence ID" value="XM_014694364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URE0"/>
    <dbReference type="GeneID" id="26239294"/>
    <dbReference type="KEGG" id="mbrn:26239294"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18182" checksum="509572B872BB474A" modified="2021-02-10" version="1">MSTDPDSQSNGYDGHTHPIERSDSSVSTATSENNEPDTSQPVIHQPVPTRPRMPSRKSSGPLVVPRDSSEVGPVDPQFGPDDVRAMSPRRTSEDIDRLGKEAREEMRRHAKALQESLITIFNRIEAVREEHDKLDNNNKFLQKYIGDLMSTTKITSSGSRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URE2</accession>
    <name>A0A7D5URE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atos-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g021920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548359.1">
        <property type="nucleotide sequence ID" value="XM_014692873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URE2"/>
    <dbReference type="GeneID" id="26237803"/>
    <dbReference type="KEGG" id="mbrn:26237803"/>
    <dbReference type="OrthoDB" id="8625101at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033473">
        <property type="entry name" value="Atos-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025261">
        <property type="entry name" value="Atos-like_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051506">
        <property type="entry name" value="ATOS_Transcription_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199">
        <property type="entry name" value="GH03947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13199:SF11">
        <property type="entry name" value="PROTEIN ATOSSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13889">
        <property type="entry name" value="Chromosome_seg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13915">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01177">
        <property type="entry name" value="DUF4210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atos-like conserved" evidence="2">
        <location>
            <begin position="343"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="781" mass="85853" checksum="EA85652F3FF73D60" modified="2021-02-10" version="1">MPIFQDDLEPDRHRHPGRPSPLQREPTSSVLRRLSEESLPTELCEGPVPNDPTRPTTPRIDEEAAISCRAELIERLKRGESPTWIPNRHLESILQRRDSPTHIRTSPESPKLLPPVQITPEKVDPGTENAVQDRLQDGLNIERPRSALHSGDFTHDQAEQDRPSSILNRQRVESQLASESSWIATSPPRDFTPFNFERRIPFQSDAGSFRSVTASPLSASLSSSFAYHPPTSPLVQSESNDELDFSMAPRSLDVPSRELNRRLSALNSAGSSPFTSPSPLGGSRLSFGRRDGSLPWQAHQPRRSLTSTPTFALHGTPPQTSAVFRARRPSFGPDSSPIQHASMVGSYEESILRGRMSTTPSKPFDFTAQIGVLGKGRCKSCLRCPPHVSLPFAAVYYSYSNTAHGRSRSDDGPSPYVGQIDLENGLPNSEEESRSKRKAHGRYLDRQPINNQSVDTLMPDFELDHDRPGTSRPRRRTGSSKAPPGGSYRIPEKGQIQIIIKNQNKTAVKLFLVPYDLTGMEPGTKTFVRQRSYSAGPIIDHIPNLSETDAQSRPMLRYLVHLHICCPSKSRFYLYKSIRVVFANRVPEGKEKLRNETTWPEPRFTPYKPIRVMHPPLNMSSGPGSMLVADKAFRRRSLGITFGGASSRAFDMVDGFDSSGGGNTLPIEPIPFRLPSQGRGDSDTSNSASNPAAGPRSPESSQASRPSTKDSAGLGVWDASGDDTGSPYEKLSRGDFGYGGSPFLGFFGNGSPGGTEGLLSQRLRSLGVNRPQPPESAEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URJ5</accession>
    <name>A0A7D5URJ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acyl-D-glutamate deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dag</name>
        <name evidence="3" type="ORF">G6M90_00g006850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549824.1">
        <property type="nucleotide sequence ID" value="XM_014694338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URJ5"/>
    <dbReference type="GeneID" id="26239268"/>
    <dbReference type="KEGG" id="mbrn:26239268"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01297">
        <property type="entry name" value="D-aminoacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="48"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="552" mass="59752" checksum="54F992206A41495F" modified="2021-02-10" version="1">MAADILFSSPTVVTGEESAIPFVADVLVSNGLIAQMGEPGSIHAPLARVIDAKGYVLSPGFIDMHAHSDLYLLTNPEHEAKISQGCTTEVVGQDGISYAPVRNRSQLQAIREQIAGWNGNPTDEECATLHRGVGMFEWRTVGEYLDCLERNETATNVAMLVPQGNLRLLACGPDDSVATPEEIQDQVQLLREAMDQGAIVGSGLTYTPGMYASTSELGVLCKALADEYPGAFYAPHHRSYGFKAIESYAEMLDLGSSTGCPVHLTHATLNFSENRGKAPLLLSMIDEKLARGVDVTLDTYPYLPGCTTLAALIPSWASSGGPTETLKRLQDPETRERIRVAVEETGCDGGHGIPTNWEEIQVGTTNHPSIAGYSGRRISEIASSLRTRPHEIFFEVLVKDRLATSCLMHVGNEPNVRAIMQHRVHMSGSDAILHGKTTHPRAYGTFTRYLGHYARELGLVSLPEMVAHLTSRPAKRLGVYPARGVVRVGSAADLVLFDAARVRDRATFDEPKLASEGVRYVLVNGVVALDEGELRGVRAGKTLRRRGDGSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URR2</accession>
    <name>A0A7D5URR2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ustYa_0</name>
        <name evidence="6" type="ORF">G6M90_00g015670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548962.2">
        <property type="nucleotide sequence ID" value="XM_014693476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URR2"/>
    <dbReference type="GeneID" id="26238406"/>
    <dbReference type="KEGG" id="mbrn:26238406"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="266" mass="30280" checksum="807D1C21F7C86FC5" modified="2021-02-10" version="1">MDKYSDQRSSTANDSDVHSVSLEKEGLLDGASIHESKPPRMRSQSRVYLLLAALMAVANVVLGALLVAQFRSSQQKAHSHRHDHHEKKPTPIPIGGLPQVNSHPDWLPPEEWRTEIFRLHEIYGEEPVGTAKEAWLSLIPKGKGFIVVKNDTELPNMPGLRHPEHEQHACVAIFHQLHCLYITYAAYWNARAGNFDDIPPEHLIHCWDYLRQSIMCAGDTSLEWVHRLDSPPGETSGWGFQHTCKNFDAIFDWAESHRYTETVEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US62</accession>
    <name>A0A7D5US62_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g015710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548957.1">
        <property type="nucleotide sequence ID" value="XM_014693471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US62"/>
    <dbReference type="GeneID" id="26238401"/>
    <dbReference type="KEGG" id="mbrn:26238401"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="310" mass="34530" checksum="0C96AA2FBB324728" modified="2021-02-10" version="1">MQSPVKIHTVESSYSDTYQEAVIANYDDPPAVWEKVLGETLSFNGGLFDEAELTAGPKPGPVGASEFRGINRQLELAGLLSPDRQLLRRILDLGCGWGVLTQHLAKVFPECQCIDAINISQQQLDYCAEKLPPELRKRVNLYLCNAQDVDRLPDPTEPYDFVFVRGVYFHLLPSVFEASVARLAQRIRPGGILLLSDPLYRDADVNAPVSTASEPSDGLGTGDHKSPQYYTSVLKKHGFQIQDLRVLPSNVEFIHWFRVLRLNIEANFPTFPNGVSVPVKDLHEFAESFAQKLAEDKVSMYSIVAQRATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USQ9</accession>
    <name>A0A7D5USQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">External alternative NADH-ubiquinone oxidoreductase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g014970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986000.1">
        <property type="nucleotide sequence ID" value="XM_066129764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USQ9"/>
    <dbReference type="GeneID" id="90967460"/>
    <dbReference type="KEGG" id="mbrn:90967460"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14468" checksum="0684EF256123F8DD" modified="2021-02-10" version="1" fragment="single">VQLQGAGDGSETTTLKDVYAVGDCTSVQGASYPATAQVAAQQAVYLAKQLNRGEGEASKPFKFKNWGVMTYLGSWRAIHQSEADNLRGWAAWVLWRTAYLTRSMSVRNKIMIPVYWVITWIFGRDISRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USX2</accession>
    <name>A0A7D5USX2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein arp5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arp5</name>
        <name evidence="3" type="ORF">G6M90_00g024470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548134.1">
        <property type="nucleotide sequence ID" value="XM_014692648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USX2"/>
    <dbReference type="GeneID" id="26237578"/>
    <dbReference type="KEGG" id="mbrn:26237578"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000139">
        <property type="entry name" value="Chromatin remodeling complex subunit (Arp5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="750" mass="85572" checksum="2AA29722B74B2221" modified="2021-02-10" version="1">MAPSAIDDPKQPRPDGKAYPPANIFPVKETRFEKYIEPQADGYKKAFEQHKGNAAIVIDNGSSAIRAGWSFESAPRFSIPPIMSKYRDRKLGKTFSFAGSDCYADTTARGHIRGAFEAGTGIVSNWDVMEHVLDYVFLKLGLNESSDGVDVPIVMTEAVANLPYSRKSMTEIIFECYGAPSLAYGIDSLFSYRQNKGNTGLVVSSSYTSTHIIPVYNAKAMLGQAIRLNWGGYHGAEYLLKLIRLKYPAFNAKLNVSQAEHMIRDHFYVSKNYDEEITSYLDWTGLEDRDVVIQYPYTEEVVVQKTEEELARIAERKKESGRRLQQQAAKMRLEKLMKKEQDLEYYKNLQAKLVDETKKEIRRQLDSHEIKDENQLDKIVKELEKSIKKARTKDVGGDPEEDQEQPNFDLLDVPDDQLDEAQIKQKRQQRLMKSNHDARARAKAEKEAEKARVAEEERLDKERRENDLDNWLEEKRQARLRTLQKIKERDRLKADLGNRKSLASQIRMKSIANLASDNPTKKRRRGGDDDDFGANDDDWGVYRQIAVGENSEDEQEEEDLATNLKNLEQELLQYDPDFDYEQTQEAQSDWSKSLLHAFARGPRPFDPASQAQLSQIHLNVERIRVPEIVFRPSIAGVDQAGIIEIAGDMLNQRLSGMPDRDALLKDIFLTGGNTVFQNFDERVREGLRALLPADSELKVRRAQDALLDAWKGAAGWAGTPAWKAATITREEYREKGPEYIKEHDMGNSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTC1</accession>
    <name>A0A7D5UTC1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g043470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547682.1">
        <property type="nucleotide sequence ID" value="XM_014692196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTC1"/>
    <dbReference type="GeneID" id="26240245"/>
    <dbReference type="KEGG" id="mbrn:26240245"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="283"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="43403" checksum="CECBE4E3C7EB2BCD" modified="2021-02-10" version="1">MTSYDSDSSDGGEFTETNVLLGYASKDSQDETISKLGGIPEWLEADKPPSAALARCKVCKDLMALILQLNAELPERFPGHDRRLYVFACKRESCRRKQGSIRALRGVRIWGDETPAASAAKAEEEPKKQETGRNNDGLALGDALFGGKGIGGGSGANPFSSNANPFSTSSSAGSSGNPFSSGQQKKDTPKEAEKDAKPATLSKSFAETLSLGTTPAGPPPPPEPWPETSAQPKPYPTLYLAEADYETLEPTSTKIPDNARIEEADAPETVSVLDREAFESSMDAAFQKFADRLAQNPDQVIRYEFAGTPLLYSRTDAVGEKLSKGSIPGCPNCGGKRTFEVQLTPNAIAELEADDLSLEGMEWGTIIVGVCERDCVPRHVGKDEAGYLEEWAGVQWEELTKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTC2</accession>
    <name>A0A7D5UTC2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ABC multidrug transporter mdr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mdr1_0</name>
        <name evidence="16" type="ORF">G6M90_00g013960</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549126.1">
        <property type="nucleotide sequence ID" value="XM_014693640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238570"/>
    <dbReference type="KEGG" id="mbrn:26238570"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="889"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="106"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="433"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="773"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1099"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI66051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1344" mass="147215" checksum="31C5538A73BA9B85" modified="2021-02-10" version="1">MASQPAEKGTLPSQFDSERSSSRARDSLDGKGTPQNEKADLKRALTKADSKVVAAPPKATDPDEMFRHLPPDEAEVLRRQLVTPELKQGVAVLYRYASRNDVIIIAISSICAIASGAALPLMTVIFGNLQRTFQTYFYSAGQMSYNSFVDELSKYVLYFVYLAIGEFVVTYICTVGFIYTGEHISAKIREHYLESCMRQNIGFFDKLGAGEVTTRITADTNLIQEGISEKVSLTLAAIATFITAFVIGFINYWKLTLILSSTVFALLLNIGIGSSFMLKHNKNSLEAYAQGGSLADEVVSSIRNAIAFGTQDRLAKQYDKHLAKAEYFGFRVKSSMAVMVAGMMLILFLNYGLAFWQGSQFLVDGIIPLNKILIIMMSVMIGAFNLGNVAPNIQAFTTAVAAAAKIFNTIDRVSPLDPSDDKGNKIENLQGNILLENVKHIYPSRPEVVVMDGVSLEIPAGKTTALVGASGSGKSTIVGLVERFYDPVQGAVYLDGQDISKLNLRWLRQQMALVSQEPTLFGTTIFKNISHGLIGTQYEHEGEEKQREMVIQAAIKANAHDFISALPEGYETNVGERGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGVVQAALEVAAAGRTTITIAHRLSTIKDAHNIVVMTSGRIIEQGTHDELLEKKGAYFKLVSAQNIADAEDLTAEKEEEDINEHQEELIRKMTTNKEGQFAVDPDDDIAAKLGRSSTRKSVSSIALQKNKPEGEKRYGLWTLLKLITSFNAPEWHLMLFGLVFAAICGGGNPTSAVFFAKQIVILSQPVTPANRDQIKKDSDFWSAMYLMLAFVQFLAFSAQGIAFAMCSERLVRRVRDKAFRAMLRQDVAFFDKDENTAGALTSFLSTETTHVAGLSGVTLGTLLMMSTTLIAACAVGLAIGWKLSLVCIATMPILLGCGFFRFWMLAHFQRRSKAAYSSSATFASEAISAIRTVAALTREHDVLKQYHDSLAEQQRRSLMSVLKSSALYAASQSLLFLCFALGFWYGGTLIGKGEYDQFQFFLCFMAVIFGAQSAGTIFSFAPDMGKAHHAAGELKTLFDRKPTIDSWSEEGERLPQVDGTLEFRNVHFRYPTRPDVPVLRGLNLTVHPGQYIALVGASGCGKSTTIALLERFYDPLFGGVFIDGKEVSSLNINDYRSHIALVSQEPTLYQGTIKENILLGSAKEVVPDEAIEFACREANIYDFIISLPEGFNTVVGSKGTLLSGGQKQRIAIARALIRDPKILLLDEATSALDSESEHVVQAALDKAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVEEGTHSELMKKNGRYAELVNLQSLAKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTJ2</accession>
    <name>A0A7D5UTJ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">citD</name>
        <name evidence="8" type="ORF">G6M90_00g029620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541209.1">
        <property type="nucleotide sequence ID" value="XM_014685723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTJ2"/>
    <dbReference type="GeneID" id="26245844"/>
    <dbReference type="KEGG" id="mbrn:26245844"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="497" mass="53179" checksum="0A9C4A6B69087C7D" modified="2021-02-10" version="1">MAEALNIPKHSIFHWSSADSSKDFVVHNPATGGILTTVRGGDAATTNAAIDASSKAFDNWKQRSLADRGQILLNCSAALETHKQELTNLLCAENGKPALDAALDVAFIVQVFGFFGSLVDKLPGQFHDRGVVYSSIIREPLGVCAGILPFNWPPIHAGGKIAPCLAAGNTIIIKPGEQAPLTVMRIVEILQTVLPKGVVQAVPGAGAEVAQLLTESPAVKMISLTGSTAAGAAVAKTASKLVKRTALELGGKNAFIVFDDCDMDRAVKGALEGAFFNKGEACTAASRLLVHEKVYDEFVNRLAAAVRRLRVGNGFDKATHVGPVVSKQQQERVNSYIALGSEEGAKIAAQADLPSDPLLKDGYFVAPTLFRDVVRTMRIAQEEIFGPVATVCSFSSEAEAVSVVNESRYGLVAAVWSKDIEKALRVSRQVDTGIVFINNYFRSGLGLPHGGSKESGYGREHYIETLNEWSTIKYIQMPSGLGQVPAWRSVKDVFDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTW9</accession>
    <name>A0A7D5UTW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g051840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539491.2">
        <property type="nucleotide sequence ID" value="XM_014684005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTW9"/>
    <dbReference type="GeneID" id="26247716"/>
    <dbReference type="KEGG" id="mbrn:26247716"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="267" mass="28996" checksum="E333178B47290A01" modified="2021-02-10" version="1">MGVVKNTYPPASLYNRLPFIHDMGHVAETYADHLNYLRNLMDTHDMPPSVCVKLIHIHFHLNNGEILAVRELNAPPHGKIPFLQPTTPDVAGNVYGCNYIVDDAGDLQAFEYTTTEGGPDLAAYPAFVAVFCAAVVQRGMQHKFGLAINSGAAERGSWMELDFPEKRATFLLPGHVALPQSDRLVLRRTITKFPRPDNDGHGNRDLPTHGHIENTWGSSKGIGPDDQEPVDGVTTKNGLQLTGVALEPGTAFYVVASAISAAVYGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU15</accession>
    <name>A0A7D5UU15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase easC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">easC_1</name>
        <name evidence="3" type="ORF">G6M90_00g051190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539806.1">
        <property type="nucleotide sequence ID" value="XM_014684320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU15"/>
    <dbReference type="GeneID" id="26247361"/>
    <dbReference type="KEGG" id="mbrn:26247361"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="505" mass="55670" checksum="CDE96D387B373D61" modified="2021-02-10" version="1">MPTSPSQPAAANGVGMAPQNHEDDSISPPSLASTGRQSTLITPRVPLIPGWMKLTPLDQIESRFILPLVLVFNMSSPALGRLVLRDLETSLASTIGEMPFLAANVVPDCEEQGTIQLEISDDAGVWFHSQELPEIDYYALERREFPPGEFPLLALMPEPRVHHAEQSPVLTVLATFIAGGLLLTFNSHHSVMDGAGMLTLATTFAKHMAALSGGRFIAPGDAFPEEALDRSNVFGCGGKEVGDFPNYRLSQTYRCAMERELVEAAVSGHHPRLPLLQKLSLSHWFISAESMRAMRDAALPPSEGLPLLTDNTILCAVLWRHISRARRLSCRGIVASSFVNTVNVRRRLDPPLPLEYPGNAVVHAKTSAATADVESTEPGMLYKMARQITDAIEWWTSERIWELVGAIESSAMVNKVEPSMDNFQGPDLEVTSTAAMGDIYRAEWGSGLGRIRALRYAYLPIKDGWVNVLPQRTDAGLELLMCLEKSTLRLLRQDEEWLRLARESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUC1</accession>
    <name>A0A7D5UUC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein argonaute</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ago1</name>
        <name evidence="5" type="ORF">G6M90_00g043890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547724.1">
        <property type="nucleotide sequence ID" value="XM_014692238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUC1"/>
    <dbReference type="GeneID" id="26240287"/>
    <dbReference type="KEGG" id="mbrn:26240287"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="335"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="619"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="970"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="994" mass="110896" checksum="3224AF993A24FFC1" modified="2021-02-10" version="1">MSDRGRSPGPSGQGSSGSRLPSRAPQGSAPGSRTGSPSRSGQAAAGWVSGPGYDPAKPATQPDKGNTRMELPPDAYVTEGQKDLFALRGNKFNTEGSNAVIEVNQYRMKKFDFAQKIYQYDVIISPDNERKSVLMKKIWTNTATKAALQKYQYNMWIFDGRKLAWAPGKVDRGELRFTVDLDEGKRPPGAQAREGARFHVTLRATTEVHIGAIQGYLDRKIQFNTNVQVALNFMDHLLRQWPSQHMTAIKRNFYSASGSGRPLLDGNVLEVHKGTYASIRMSHNITRGGTGLALNVDVANTVFWTGPQPVDQLMCNFLVLCDRKWRGLNPSTIGQVLRPVRNNEGRYQSSDAFKHLRKLRKLKFTVTHANRPASDKVYTIMDFAFDEKYGGEGATARTVTFECNGTQISVADYYKQKYKVHLKNPSLPLIFAGKGGFIPMEFAIIEPMQRYAFKLTPDQTAAMIKIAVTKPQQRRADTENNYKGLQLSTDPYLKMYGVEFEPTFTKTDARILPPPQVNFGQGNADPKFAGRWDLRGKKFWKQNVAPLQNWAFIVMDACVGYQQLQNFAKTFRNAFLAHGGKCPADALLLNVPGDVKNDVAQAIAWAHKQICLQRGYTQLLFVVVQHKNSPHYERLKKSADCRFGILSQVVNGSAVANNNGQYHSNVCMKVNAKLGGATSRTLPPWKSSPTYFPKDRPTMIIGVDISHGAPGGGSPSTGAMTMSIDRDANRYAAVVESNGYRVEMLTAANIHVMFGQLVKYWMAGHEGAFPKHIIYFRDGVAEGQFAQVLDQEIREIKTYLREKAPNAQPPKFTVIVATKRHHIRFYPQKGDRNANALPGTLVEREVTHPFMWDFYMCSHVAIQGTARPVHYHVILDEMGIPVNDLQKMIYHQCYSYARSTTPVSLHPAVYYAHLACARARAHENVASSEGFRAGAKGHEMIRDQVAMGQTMEGPSRGIDAPPLLQLGGKPEGDKPPADGEMRQRDFIRGTMWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV54</accession>
    <name>A0A7D5UV54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g036700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986187.1">
        <property type="nucleotide sequence ID" value="XM_066130184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV54"/>
    <dbReference type="GeneID" id="90967620"/>
    <dbReference type="KEGG" id="mbrn:90967620"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15345" checksum="2089B7A532359693" modified="2021-02-10" version="1">MTRGTRLPHRVLLHLGQPIATSSKFVLATKPRSWKSVARMLKRPPKKLARTVAAEAAPSTLGQQTIQTMLQQTSPQFAPTPVAMERQPRTSMNPPLESPKRRRMGLRLKSLLTIAAVLLLPLVALDAAINKSPSLQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVN1</accession>
    <name>A0A7D5UVN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g038050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986587.1">
        <property type="nucleotide sequence ID" value="XM_066130231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVN1"/>
    <dbReference type="GeneID" id="26239727"/>
    <dbReference type="KEGG" id="mbrn:26239727"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27434" checksum="365E76FB7C018103" modified="2021-02-10" version="1">MPPTIHLVRHAQGFHNLCVENESLRDPDLTALGEQQCADLRSAFPSHARLTGLVASPLRRTIQTCDLAFGGADKLYPIVLLDTLQEVSGAPCDTGSSKAALRAEFGDKIDLQRVRDSWTEKGEGSAFEPTMEALMARAKTARRALREMAGDGDDEIAVVSHGGFLHFLTDDWDGVPLDQATAWTNCMCRSYQFAESPDDKDDVRLVETKESWARRQPASRQPLTATEQREIRAIVQKRLLPYLKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW37</accession>
    <name>A0A7D5UW37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g048470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544962.2">
        <property type="nucleotide sequence ID" value="XM_014689476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW37"/>
    <dbReference type="GeneID" id="26242303"/>
    <dbReference type="KEGG" id="mbrn:26242303"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="534" mass="60162" checksum="43B6754ED68EFD32" modified="2021-02-10" version="1">MSEGLLTQEQAVSKLLAFIFSGAIGPAKGKAVGYSLVATKPTEFSWWVALEDIDGPDVPLDRYCVKLDRRSRHISPPEPVVLSKEELSDAILSATGQHLASSARFTDGALSISYKVTVQETPDVAYVVQLRHHGNVASMDSLMTLISKTVGPHILPVPPVYPIPGEGRRQQVTGVGRQITRLIPGVVASTTYPHLSHDEKLSFVRKMALAFQACWSIPIPQRLIGELVSTKVGDDIILSVGPDRHNSLGGPFQSVREYLQAYIRASIIALEKQEGIQEYKDKYLKRIKDFVHDHMHEIPPIVEDVPIVAMHSDMGPHNIIVSSQTPTNLEAVIDWEFAASAPFATLHRIIEMMFRESAANEFGPEYGRASELREAFWDTIPDWKLWVESEPCRVFLEWFRFGLFMKPEWRPDDLAEEDAREFWRENIRVVEGMLEKLAQPCALPANRPRLYGPLRRRRHVLDVRVWQISAIRRHEYPKVTYLLALIRPSDNAPLADEALQKSIHKTYTDAYRLTGFKGGNWAYASNANDTVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW93</accession>
    <name>A0A7D5UW93_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Eburicol 14-alpha-demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CP51</name>
        <name evidence="15" type="ORF">G6M90_00g065260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540248.2">
        <property type="nucleotide sequence ID" value="XM_014684762.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW93"/>
    <dbReference type="GeneID" id="26247057"/>
    <dbReference type="KEGG" id="mbrn:26247057"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="523" mass="59222" checksum="9C758BF9E0B1EFE1" modified="2021-02-10" version="1">MEFRPFTEHLKRMAYVSPILFLGSCLLLLVLLLIVVNLIRQQLPASKSEPPLVFHWIPFIGNAVSYGLDPFAFYSQCQKKHGNIFTFVLFGRKMTVYLGLQGNDFILNGKLQDVNAEEIYAPLTTPVFGSDIIYDCPNAKLMEQKKFVKVGLTHDALCSYVPLIEKEVVDYLKVAPAFRGQSGTVNIPAAMAEITIFTASRTLQGREVRGKLSAEFAELYHDLDLGFRPINFLMPWAPLPQNRRRDAAHAKMRSIYIDIINDRRVSGKVPDQDADMIWHLMTCVYKDGTPLPDKEIAHMMITLLMAGQHSSSSSSSWIMLRLASRPDIVEELYQEQVRNLGYTGSEPLQYSDIDKLPLLQNVIKETLRVHSSIHSIMRKVMRPIPVPKTDYVIGPDKVLVSSPIMSHMSEEHFANAHVWDPHRWENMSTEEKGDMVDYGYGQVSKGTKSPYLPFGAGRHRCIGEKFAYMNLCTIIATLVRNMKFTTVDGSSAVPPTDYTSLFSRPMQPSTIRWERRANVPSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWN6</accession>
    <name>A0A7D5UWN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heme-binding protein HMX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g055110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540895.1">
        <property type="nucleotide sequence ID" value="XM_014685409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWN6"/>
    <dbReference type="GeneID" id="26246201"/>
    <dbReference type="KEGG" id="mbrn:26246201"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29474" checksum="464222A4D90D8644" modified="2021-02-10" version="1">MGDIDLPSKIKEVIRGVHGKVNRLNTARIPLCLPPRAKSPAIYTLGLSRYAEIFLGLEKVWNDLIGDASEWMGNMSYKPSSYKSDKERVQAVLRTIYLPELLRTKRLQADFAALKPLHAEMDNLDPGGGNAGSEFRKYIEQDVSTKPHLLVAYVWIMYQALFNGGRFIRAQLLKAGPEFWGLSAQEADLTALPPPLSFWRVQEAELVKARFRDCVVAADKLLTEPERREILDEALEIFRRCELITLQLDEDAARGAAYEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWT7</accession>
    <name>A0A7D5UWT7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gcn2</name>
        <name evidence="16" type="ORF">G6M90_00g062760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986665.1">
        <property type="nucleotide sequence ID" value="XM_066130752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244555"/>
    <dbReference type="KEGG" id="mbrn:26244555"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000821">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000074">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="45"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="283"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="596"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="161"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1469"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1473"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="818"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="602"/>
            <end position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI68778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1608" mass="181276" checksum="F8F6CD466F9BA7DC" modified="2021-02-10" version="1">MAWQASSAWKKSLSKASSDDSSFPGLKPTTPDATTKIEYEELQQNELLALEAIYGDDFVKHSDVHSAWKKTEPSFDIRIKASIDSDFAVTVGFVMTATYPKTPPLLTVKGLDDLRESTQFKIQKFVDTEPREFAKDQQEMVDRIVEGIRDILEDAAQVKASGKQLPSLEEERERHEAKLAEKARRQKEDEERKKMEETKEEERVMSEMLQQQIDRQRQKAKESRLSRRPNGLEGLPSDNSAASIERIDFDQFCHVKNKEGNILSFKSVTGKCDPREGKVTVVYTVRPVLGNGQGDQTLALKEAILRPNGRDPKEFKKQLQSVESRLQELKNTKSIHHNRLVEILDFKVESGKSDDAAVANFWTVRILMPMAVKGSLEELLDLAGHLELGKVRSWTRDLLDALSFLHSKNIAHQDIHANNVLLFRESTGEFVPKLSDCWYQREIHNASTPKPGLPGLTSAKSAYWLPPEIAGQSKPQYSYKTDVWEFGIVFTQMIFGLDVLQKYSSPRNLMQELTLSQPLEELVSRFFKEDKQKRPRPFELGSSEFLATDAPVFLESDSSRALSATPSLTSLHVVPARLRRDSMSRGAVVSRYTEDFVEEGRLGKGGFGEVVKARKKLDGQIYAIKKVTQRSHASLTEILKEVRLLSQLSHPAVVRYYNTWVEEVPDSTDTEGDTSTEGCTEETEETVSDGIDIQFATSTGGLDFMSSNAAIEFGYDDDSDDNAIEDDSDDDSSIVADQAGNGVLSPGKERAGQILRRARQHRAFRTILYISMEYCEKRTLRDLISRNLYKDTSEIWRLFRQILEGISHIHALGIVHRDLKPENVFISSSLEGVDNVKIGDFGLATSGQFSVDKVAANSLENDSMTRSIGTAYYSAPEVRSAGNGLYSAKVDMYSLGIIFFEMCYHPMIGMEKADVIGKLRRPKPELPSDFKPAERNQTDIVLSLVNHNPKERPSSADLLKSGKLPVQMESETIRRTLAGLGDPSSPYYSKMLSTLFARPCDAAKDYAWDMLGTQPSASELLNQGVVRSTLISIFRRHGALEMPRTSIYPRSSQYGENVVQVLDPNGTVLQLPFDLTMGNARMIAKQTGGPILQRSFYFNNVYRDKLDTGQPSVFGEVDFDIVTTDTLDLALKEAEVLKVLDEIVQAFPSLSNAQMCFQVGHSDLLQLIFDHCGVESSCRRQAAEALSKLHVHGHTWQKVRAELRSTTVGVSATSVDELQRFDFRDTPNKAISKLKVLFEGSDLYQRAMPTMAHLKEVAEYCKRFGVISKFYVSPLNSLRENFFMGGIMFSCVYDRKTRDVFAAGGRYDHLIKEQRPKIGGNFEERHAVGFSLAWERLARVPNKSGSKTFLKKQESDSNTMFSGRRCDVLVASLDAAILRSTGIEVLQLLWDHDISAEMAKDARSPEDLLSKHRNENYTWIIVIKPEAMLKIKTMGRKDVQDVDIPLGQLMAWLRPELKERDSRALAKLRGNVSHGSESSGTHNSDRNQDQDVKVLVAGTKSKKFNRRTVMDQAQVSASNLMRSYLDGPILAIETTDQVMDLLRETRLSEHESWKSVEHAVTMTEKKYIRELHSQLDTWRSTYEMKNISKHAFIYNFRTGTCVYYDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXJ9</accession>
    <name>A0A7D5UXJ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine-protein phosphatase non-receptor type 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g057620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986700.1">
        <property type="nucleotide sequence ID" value="XM_066130646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXJ9"/>
    <dbReference type="GeneID" id="26242755"/>
    <dbReference type="KEGG" id="mbrn:26242755"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65207" checksum="4AD254095F98F43C" modified="2021-02-10" version="1">MDPVHSLADATAAAAAASSSSLSMLTTVRDEDGCNPIESAAPTPGVVADTVKSTSPSPPAAKVDESLVRHAMYSPTSPRLMHSGSPPPRKDTLSSISTQATTATTASAETNNTSYSADTSPSLHQSIFSVKDGSDVSNTRRASRRRTGPLSQQSRERAALIRKLGACHDCRRRRVACHPSHHNMTWEDLLHRFHRSQSPNSQDVTPSFGAGRPLSPASSLSIIQPTFAHETQAMDIDSSPTAYHQPGRHPLSEARIRTPLPSGPRLEKSLSLPGIESLKNELQHNVPKILSTTHRGRYNSVQVLLLFWHDDEDATTIQDALQELAHVFDRSYHYTFHIQAIPSASDSSKSSWRWLSRRLNDFAEDCDQRDVLKIVYYAGHTCLDGNREMILTSSMDKDQASTIRWSGMQQILEEACADVLILMDAAYYPSSKIVRRKGVLELLAASASEDHATSLGRCAFTRALSELLSARAARSAPLSVVELHALLLSHYPKIVRDTTPERETLTTFPVPLHTMMSGNSRLPSVFLSPIHHPSPTRNSFSYENNPQLHLSIRLTDDNVDIESWNEWLRLMPEGVKDVKIDGPFRPSFRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXP9</accession>
    <name>A0A7D5UXP9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g063480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542535.1">
        <property type="nucleotide sequence ID" value="XM_014687049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXP9"/>
    <dbReference type="GeneID" id="26244484"/>
    <dbReference type="KEGG" id="mbrn:26244484"/>
    <dbReference type="OrthoDB" id="5333491at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="318"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="510" mass="58049" checksum="B2107F9DF00AF480" modified="2021-02-10" version="1">MSWNMLPRQIRNDVLARVVETAYSNDEPLAGYASVSRDWQAFFEQHTFCSLDVTPGDLDMFETSFQEPGRKRCLRRVGLVLDLPQHPPIRLHNDQGATEEETALLLMRRIWGGGPRDSFYPPELSHQKTLDDMALVSGISSLFGILAAWTRHQVSSHGVALEIIADSKSYWQKMAERMRRYGGIPATPGMPVPGPWVLSSTQFPAAFFSLSQYDWQGPVCAAQEDFNFELGLNHGGAPMEPTRSSATRGCRQWFPSVSVISAMSVLRRTVRRFHPDALGAIIWSLPCLRMLDWQLRPLVACKSKRPLDLDIVHVLFSLPMSLRHLHITQVHTYFLRYWRGDYEPDGVLFRILWYRLSELKSLSLEYDGHTLESYMANSTTLWPNLESLILSAKGSIGDSPTHDLNRLVRNAVYMLLRTPRLRSMMLYDTTGHGVGCFTCRFEEDTLALRFKCSWFFVPDADSMASWRDMAVALGIENISWDSEIADISHIIEYINGVRIRIPILMGGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY39</accession>
    <name>A0A7D5UY39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DPH3</name>
        <name evidence="10" type="ORF">G6M90_00g071240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545935.1">
        <property type="nucleotide sequence ID" value="XM_014690449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY39"/>
    <dbReference type="GeneID" id="26241968"/>
    <dbReference type="KEGG" id="mbrn:26241968"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="85" mass="9520" checksum="6054BED064D880DB" modified="2021-02-10" version="1">MSDDENLSIYDEIEIEDMTFDEALQLYHYPCPCGDRFQIALDDLRDEQDIAVCPSCSLMIRVIFDLDDLPKPPPSGNGAQVPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYD8</accession>
    <name>A0A7D5UYD8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ubc11</name>
        <name evidence="17" type="ORF">G6M90_00g057260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544310.1">
        <property type="nucleotide sequence ID" value="XM_014688824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYD8"/>
    <dbReference type="GeneID" id="26242722"/>
    <dbReference type="KEGG" id="mbrn:26242722"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000068">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-20 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI69319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="180" mass="19741" checksum="2F38223F8C25BD68" modified="2021-02-10" version="1">MDFATEDNQNSAPGSVPATKLNTSRKGPDSQSVTKRLQTELMQLMTSPAPGVSAFPSADGNLLSWTATIEGPDDTPYAGLTFKLSFAFPSNYPYAPPTVLFKTPIYHPNVDFSGRICLDILKDKWTAAYNIQTVLLSLQSLLGEPNNSSPLNGEAAELWDSNAEEFKKKVMGRHRDIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYR0</accession>
    <name>A0A7D5UYR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g077480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986971.1">
        <property type="nucleotide sequence ID" value="XM_066131072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYR0"/>
    <dbReference type="GeneID" id="26241387"/>
    <dbReference type="KEGG" id="mbrn:26241387"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="489"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="637" mass="71329" checksum="13E85E11329ADCF9" modified="2021-02-10" version="1">MSDIVSRLEAENEELRRQLATLRPSGTTSHSTTTCSTSKLPDQAPESTHLSTNDPIGLKGTSPKDALQRRKDERNSWIHHSKYLKEKIQTAENEYGIQILDQKAQQMEVPTSTALEADEPLINPSLSFMSEKGPEEDEPQLPELASTSKSSGGALEGHHANSETTQGEASDEMSQPLPMIPPPSNSEMVVIKEEQSSDIPEIVSEREVRKRKRNEEHAVTTVVPKIKPEMAGSSSPVMLISPVQFHTQESIDLGDIVKKIQTPRKRQLLEQAGPQSEIITRSKLTTFTPLHAGAQQEPQSAIAPRQTSALMPLSVNARTIRPSSVKIQQKSRWSQLNESIESLAEDGAAYNAQALTNQVKSPSVSSTKSRLNALLNDPLAESEDENIISRLPKRAEPRTAARHADLGIPGRRQLPFDKDGHVSGRTTPCKQSLSLKSVSEAKTRGGSFASPRQTMNRQDSRPLRHRPLSKLGLEDFKVNLRANEGHDFAFSEVVRDKGDRSCLPGCTDMHCCGKEFRALAISQRPNPPLTAAQRQEEQKLLEDYLGDFSYRLASMDKDERMEVWIEAKTHELANKYGKHRHRFSRMQSPPGFWDADFPDTQQLEADREEAVRRTRRAVAERYREARRPGGRWMFKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ62</accession>
    <name>A0A7D5UZ62_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g063870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542499.1">
        <property type="nucleotide sequence ID" value="XM_014687013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ62"/>
    <dbReference type="GeneID" id="26244448"/>
    <dbReference type="KEGG" id="mbrn:26244448"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10654" checksum="F3DB7D12F9428311" modified="2021-02-10" version="1">MSSSDLPRVAVGGKDSRTDYISKTLNISFGHDHWKEELMQLKRVDVALATLRPPPDALVYRLYGAFRHDDELEGMLFTCTDENEVLCQGRAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZB6</accession>
    <name>A0A7D5UZB6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">APP1</name>
        <name evidence="2" type="ORF">G6M90_00g072610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545802.1">
        <property type="nucleotide sequence ID" value="XM_014690316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZB6"/>
    <dbReference type="GeneID" id="26241835"/>
    <dbReference type="KEGG" id="mbrn:26241835"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="1">
        <location>
            <begin position="206"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="46175" checksum="573FDBB73F5F5CF4" modified="2021-02-10" version="1">MAHKNYTPSTLASAMQLKTRKEKKFDEIESRLGLAKSSTIPLAQGQSRLTGWLNRFNLLQPFAKPATDNDIVWLLDNTAYKSTRTGGWQAEFVAAVFEREDKETLMDMVTGVIRAVGLADDAAERDTVEERVLPFLWDIRPATIVTASQNSKELKLGPTNINGLTSNMLKISSGNSGSLVNASTKIGGGRGSIIKMQTYYAGEDGWGIISDIDDTIKVTMTSDPVGILRETFINSPAPIPGMPELYTEIKSFLPKDTAWFYLSASPYNLYPFLKQFRKQYYPPGTLILRDSSWKTVAGLLSALTLRTEEYKVDRMKKINRWLPRRKMIVIGDSTQSDPEAYGEMYRTVPGWIRLILIRKATDVAAVGIDEKNEPERFEKAFKDIPRDAWHVFEDPKECVEIIGKTIQREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZI7</accession>
    <name>A0A7D5UZI7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette sub-family D member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">abcd1_1</name>
        <name evidence="10" type="ORF">G6M90_00g071250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545934.1">
        <property type="nucleotide sequence ID" value="XM_014690448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZI7"/>
    <dbReference type="GeneID" id="26241967"/>
    <dbReference type="KEGG" id="mbrn:26241967"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="463"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="709" mass="80955" checksum="2AC5AC2B6C49AF50" modified="2021-02-10" version="1">MASQSKLSLSGDHTIRNIVTELTRLYLSNRTRISRAIWITLFVALVNRVRHAISEQKAASVREAAQREARRATVSTSGEETPKKKVALDRQFFRSLLRLLKIVVPGWRSTETRMLISHSFFLVLRTLISLRVAEMDGAIVKALVKGNGKEFMTRILWWMLIAVPATFTNSMLSYHQAELSLKYRTRLTQYIHDKYLSNLTFYGISALDDRIKNPDQLIAVDVSKFSNSLAELYSNLAKPLLDMTIYTWSLSKSVGGEGVVFMSLLVQLSANMMRVLTPPFGKYVADEARLEGEFRFQHSRLIDYSEEVALYGGHVAEKDTLDKGYFTLIKHVNYILRRRFYHGFMEDFVIKYFWGALGLLLCSVPVFVKLPGQVAMNMGDRTESFVTNRRMLLSASDAFGRIMFSYREIMELAGYTSRVASLLDVMDDIQSGHFEKRLVSSSGTEDNEAVLRGRGTVHESEDIKFIDVPIISPNGDVLVKALSFSLSQGDHLLVVGPNGCGKSSLFRILGGLWPVYGGTVYKPPFHAIFYLPQRPYLSRGSLRQQVIYPDSLRQMRARSVTDADLMSILKLLELEHLVDLYPEGWDAEAEWRDVLSGGLQQRVAMARLFYHRPKYAILDECTSSVTLETEKIMYDNAKALGITLMTVSHRRSLWKYHTHILQFDGQGKYVFTRLDADKRLRLEDEKEELEVKLRQVPELERRLEELTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Q1</accession>
    <name>A0A7D5V0Q1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987184.1">
        <property type="nucleotide sequence ID" value="XM_066131068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Q1"/>
    <dbReference type="GeneID" id="26241408"/>
    <dbReference type="KEGG" id="mbrn:26241408"/>
    <dbReference type="OrthoDB" id="5402146at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028909373" evidence="1">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="131" mass="14351" checksum="622A3E3841629164" modified="2021-02-10" version="1">MKLFSTSLVAVSALAGFSYAWDVTSYRYISDCRVHDDGAYRYYEGSDSKTCHNLAGGDSGASCTQYTNGGDHHANCDGERVGREATGFVLAEHSSLLPATFDGLRYAYITRLKLATKQVNSGIYRLWEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V105</accession>
    <name>A0A7D5V105_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable aspartic-type endopeptidase OPSB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Probable aspartic-type endopeptidase opsB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g087500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542366.1">
        <property type="nucleotide sequence ID" value="XM_014686880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V105"/>
    <dbReference type="GeneID" id="26244880"/>
    <dbReference type="KEGG" id="mbrn:26244880"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028872993" description="Probable aspartic-type endopeptidase OPSB" evidence="11">
        <location>
            <begin position="16"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="67"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="469" mass="50122" checksum="00E43B3DA1A4ACC6" modified="2021-02-10" version="1">MKLLTFTALLPYVHGLSIPDRQDGSPRVVGLPLHRSEIRDPVTHDRNRMRKRDGTVNATIDNLQTLYFLNASLGTPPQNVRLHIDTGSSDLWVNTRSSQLCSMRKRPCAESLVYTANSSSTYKYVSSNFNISYVDGSGAAGDYVTDTMSFSGVNLSSLQFGVGYESTSEQNVLGIGYPSNEVQVVRSGLKPYDNLPAKMAADGLIASSAYSLWLNDLDSSTGEVLFGGVDRDRFRGSLISLPIQKVGNGYNEFFITMTGLDVGSKNVGKNMALAVLLDSGSSLTYLPDSMVESIYGMVEASYDPSQGAAFVKCSVQQTIASMTFNFSSPASVTVPMNEMLINVSDTEGEQLIFGNGEPACLFGILPAGKASSVLGDTFLRSAYVVYDTENNEISLANTIFNATTSNQVEINSKSTAPFATKASNPITATSGLPGGINSKGNTQQPGNAASSLAPSLTLLFVCMMARALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1E5</accession>
    <name>A0A7D5V1E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARDH</name>
        <name evidence="7" type="ORF">G6M90_00g091660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541814.1">
        <property type="nucleotide sequence ID" value="XM_014686328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1E5"/>
    <dbReference type="GeneID" id="26245282"/>
    <dbReference type="KEGG" id="mbrn:26245282"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="347" mass="37355" checksum="17AE9CB9FDE21C3A" modified="2021-02-10" version="1">MASRQTIFAPMLRHATRSVAPATLRPSFAAARNLHNIPPRSNKPGSYSRTDADIEVEHPEEHELPSSKPVLGTGGQFVKPTLPSFSLDGRVGVVTGGARGLGLVMAQGMVFSGADVALVDMNKEEAQKQTQLLMDAFHRENPNAQRIPTVTAHYADVSDPESVESCIAEVIEQHGKIDHLVTSAGFTENFEAVNYPIDRMRKLWAVNVDGTYLFATSVARHLMARKAPGSMVMIGSMSGAIVNVPQPQAPYNAAKAGVRHLAASLAVEWAHAGIRVNCISPGYMLTALTEKILDENPDLKQKWTSLIPQGKMGQPQDLMGPVSFLLSDASSYVTGADIRVDGGYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V223</accession>
    <name>A0A7D5V223_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g092150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987512.1">
        <property type="nucleotide sequence ID" value="XM_066131414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V223"/>
    <dbReference type="GeneID" id="26245327"/>
    <dbReference type="KEGG" id="mbrn:26245327"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="239" mass="26126" checksum="EEBE5C0ADB23F138" modified="2021-02-10" version="1">MASITPFKIAVPDAAITKLKAKLELSDLPDEVDFSNDWNYGAPRDDSSASPIQDDHTRRRLRKAPRSLRAQAEPEARQYPAPLLPRMYVRPVSSASTTLASPSSGQLTPSPSWPGCTRSCTTGRTGYPWTDDEVLTWGLVCVYQFSAAGAAASVRIYYEARHAGAARTRRGLGYVPGVPLGLSYFPRDLVLPPRTWPVVFERVHGEGGHFAACERPEALVADLRAMFGGGARHVAERFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V224</accession>
    <name>A0A7D5V224_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g082670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987464.1">
        <property type="nucleotide sequence ID" value="XM_066131206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V224"/>
    <dbReference type="GeneID" id="90968064"/>
    <dbReference type="KEGG" id="mbrn:90968064"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="45568" checksum="1E658E507556F641" modified="2021-02-10" version="1">MLKVGNTGNVGTAEMQDLILSSKGPTPGAILMEWNIQAKDKGNAALWDVYIRLGRAVKTELMPVECPPNKKETNPPNCRVAISGKRPRISRTSGPGLPITRWMAQIPDLNDIHSNTEQLSAYSARGILIESQKATWWFRTASEHKVYNRYIFHGAGNIFATFLVTESAYYQPTTAPPFPFENAVGVFDSDPGYSWEAGDAHGCDASWSVTMTNCQSVHPLWLIDDNYDNNRLRQITSIGAKNMIVSTEQQCWVYISLFEMPRIEPPPEKNCPGTQLTNGRNSSEYVIAYLDFKKWEFVDIPSDKPWKNEADYDQMMGDFTTTNGYANYQIEGTNTTLVLHGKPNEITDGAWWARGSAANAETQILQPVTSWRAAPDMRIASVENGTFYDAHINDDTGSHPAGATGPLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Y6</accession>
    <name>A0A7D5V2Y6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-1-phosphate phosphohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GPP2</name>
        <name evidence="1" type="ORF">G6M90_00g103600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545988.1">
        <property type="nucleotide sequence ID" value="XM_014690502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Y6"/>
    <dbReference type="GeneID" id="26240411"/>
    <dbReference type="KEGG" id="mbrn:26240411"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="238" mass="25690" checksum="2B23DBB67BB61A6F" modified="2021-02-10" version="1">MGSQHNYTQPPQQASFDGFLFDMDGTLIDSTEAIVKQWSKIGTELGLNPEEILKTSHGRRSIDVFKIVAPHKATWDYVRGVEAQLPLLYGDLASEIPGARSLLDALIAQSAPWAVVTSGTEPLVSGWLKRLKLAIPEHLVTAESVQNGKPDPACYRLGLEKLGLQDRPRQVLVLEDAPAGIKAGKAAGCKVIGLVTSHTVEQVVAAEPDWVVQDLESVRVVGREGGKVTIEISNALVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3B1</accession>
    <name>A0A7D5V3B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g096010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546730.1">
        <property type="nucleotide sequence ID" value="XM_014691244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3B1"/>
    <dbReference type="GeneID" id="26241153"/>
    <dbReference type="KEGG" id="mbrn:26241153"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="243" mass="27043" checksum="99CF5311BBCCDC46" modified="2021-02-10" version="1">MDTACAVCKKSPPEVTLKRCARCSTTPYCSRDCQKADWKSHKKICSSQAQAKPSSADKLSPPKGLEGGVAKPFTRLDNGTWLHDRSEKDVYMLLIDAYRLNVDDMYNLEGEVDDDSLYSGAPDGLLGFQRFLRRAASRRGLLPPWWDASKRRDCEAFGMTPQEGNYRAYLECAVEKSDIIEKYGDSQFPMQLRMLSEAVIGRVPGGSDGKALRKLFAGMEGMEHADAEGMPFSILNAGTFFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3L3</accession>
    <name>A0A7D5V3L3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable beta-glucosidase btgE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-D-glucoside glucohydrolase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Cellobiase btgE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Gentiobiase btgE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">G6M90_00g097430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546598.1">
        <property type="nucleotide sequence ID" value="XM_014691112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3L3"/>
    <dbReference type="GeneID" id="26241021"/>
    <dbReference type="KEGG" id="mbrn:26241021"/>
    <dbReference type="OrthoDB" id="4082933at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028958373" description="Probable beta-glucosidase btgE" evidence="14">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="248"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042762"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI73935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="588" mass="61340" checksum="BAAD96DF4C4A66CC" modified="2021-02-10" version="1">MKGEFVAAALAALASGVSAAHHRHAHEHLFKKGLNDTAAVCTPGCTTIWKTMTGEPTLVAPSTKTQTQILTVTPSPKTSSIQAPPPPPPTTQAPPPPPATTEIVVVPTAVVTTCPTPGTYTFPATTVTIQKTTTVCDATSTKVPPGTHTIGGVTTVVVTATTVTCPVATIHTSGSVTTSTIVQTTYVCPSAGTYTIAPITTTVSKETVIVYPTPATYSPGTYTAPQQVVTVTKTGFVYICPLTSKGLTTSTPVSTSTPAPAPTSVKTQAPPPPPVKTTEAPKKSETPPPPPPAKTSEAPKSSQAPPPPNNNGGDLVSNNDHLGMTYTPYVGSTGQCKTAGQVDSDISAIKNAGFSVVRVYSTDCNTLENVGNACSKYGMKMIVGVFVKSSGCSINTPDIKEQVDKLVAWGKWDIVVLLVVGNEAIMNNYCSPEQLKQLITDVKGKCSGKFNGKVTISETLNIWQREDVSSNLCSEVDITGANIHPYFNNGVAPSEAGQFVRGQISILQKICNKSVITLEVGWPSGGLDNGLAVVGLDAQSIAVKSIREECGNEVVFFSLENDSWKQKGSCGCEDSWGLGKAFNILTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3R7</accession>
    <name>A0A7D5V3R7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g095500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691294.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26241203"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="313"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="749" mass="82077" checksum="9D37516DFD962790" modified="2021-02-10" version="1">MASRHVPNAPRGIGQQRVVTYAGQARKRPSTTATTRDPDPDSSRSKLSQIYDYPSSPESTYQPSKLQDSSLKVSKKIPISSSSKPNSSTAPSKTPRPSPSKNGLARKRDHAAAFPADRGQKTPKNKANDEKDGSRNAADILARPGPSNFTQHDAKQAWKNRSSDRDLVSASATPVKRTNASSSRRPRLIDALAAQKKSLSPGDDDGEREPSLGVEQTSDMRRDFQSQDAGRSIRTPDRRGTTTPANRKVRFTYSQSRRIVSESQTPELFDSPSRAQENELDPLLAETRAISSPPADAFAPDDSDDEDNTQPAIKSVHELRRAGANNRFADEMDDLIARIGLPGTSSATMRRNALCELVQKLQRKEFMRQFRDHTSRDTVARDIGKEQDIICGFALVSYLLSFLTAGPAPNLLRQLAGDGVGRLLGLLLRVDEDITIIASQKKMNMSRMSKLSVDGVKSILQGLPIWHGYQPVSPSPRTAALQLMALLSRCADAVFLDQILSDAHSDIVSVATWASEEGSCDEVDYALTVFTLETQSSAGVAPRLNSDGGHPARIAKLLSRALQQWPSGRPELDSAILKLAINTTNAEDEAAAFDDPQLSTKLARRVGYLFADVRSTIFAGKLDGETYDELLLMLGVMINIMEHCTPARRAVTEDTMDNLVKLWQDNKESVGEADSVDKSKLSVAVGYLSVLLGYMCLTRQARGRLEHRVGNGALQSLRTSIQQFASMYKAVDNKAHAMDILVQELRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V442</accession>
    <name>A0A7D5V442_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DIP2</name>
        <name evidence="8" type="ORF">G6M90_00g102980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546050.1">
        <property type="nucleotide sequence ID" value="XM_014690564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V442"/>
    <dbReference type="GeneID" id="26240473"/>
    <dbReference type="KEGG" id="mbrn:26240473"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001884">
        <property type="entry name" value="WD domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000755">
        <property type="entry name" value="WD repeat-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="423"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="504"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="603"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="645"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="692"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="829"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="962" mass="107463" checksum="FE700A594CFAB97F" modified="2021-02-10" version="1">MVKSYLKYEHAKSFGVITTNTSNILWAAKDRTSSGAGQAVVAANEEVLCWDIKKGELISRWRDERCTASVTAIAQSKADKDVYAIGYEDGSIRLWDSKISTVIVNFNGHKSAVTKLAFDNSGVRLASGSKDTDVIIWDLVAEVGQFKLRGHKDQVTGLQFIEPKLQVENDDGSRAMLLNDENSSDGFLITTGKDSLLKLWDLSSRHCIETHISQTNGECWALGVSPDVSGCITAGNDGEMKVWSIDTEGLAASTQQVDISAAAHYLHDRGILHRQSKDRAIEIIFHPQRDYFAVHGSEKSVDVWRIKSEAEIKKSLARKRQRRRQKQKDSKAEEHDAENGDEANEDVSKANVGDVFVQYVIVRTGGKVRSVDWATSSNQKDLQLLVSTTNNQLEYYSIPHKERIERKKKDDIPDYTRGLAVELPGHRADIRALSLSSDDKMLASAANGSMKIWNIKTQACIRTFECGYALCCAFLPGDKVVVVGTKSGELQLFDVASASLIDAVQAHEGAIWSLSVHPDGRSVVSGSADKTAKFWEFKIVQEEILGTKRTTPKLKLVQSRTLKVSDDILSLKFSPDAKLLAMALLDNTVKVFFVNSLKLYLNLYGHKLPVLSMDISYDSKLIVTSSADKNIRIWGLDFGDCHKALFGHQDSILQVAFVPHNSDGNGHHFFSSSKDKTIRYWDGDKFEQIQRLDGHHSEIWTIAISHTGNFLVSASHDKSIRVWEETDEQIFLEEEREKEMEELYESTLTTSLENDPDAEGENGEVAAATKQTTETLMAGERIQEALEMGMADLNLIKEYEEAKLTNPHAPPPQRNPVFLALGNITAEVHVMSVLQRIKASALHDALLVLPFATVPILLTFLNIFAMRSMNIPLTCRILFFIIKTHHKQIVASRTMKSMMDGIRTNLRAALKRQKDEMGVNIAALKVVGMQLRDKSIKDYVDEKWEDENPERSAKKRAFVHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V447</accession>
    <name>A0A7D5V447_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3-hydroxyphenylacetate 6-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phacB_0</name>
        <name evidence="9" type="ORF">G6M90_00g094400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540804.1">
        <property type="nucleotide sequence ID" value="XM_014685318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V447"/>
    <dbReference type="GeneID" id="26246417"/>
    <dbReference type="KEGG" id="mbrn:26246417"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="531" mass="60148" checksum="EA47E2A428BB022C" modified="2021-02-10" version="1">MLSVVGLLSLIREQERRFTLETLAVTCILAPLVYILVNEVIRYHARIGGMKGPKGLPVIGNLWDIRVNAAEKYREWARKFGDVYQIQLGNIPVVVVNSAAAGRSIFGQNAQAMSSRPEFYTFHKVLSDTAGTTIGTSPYSDSLKRRRKGAASALNKPSIQMYISHLDIESRDFVRELYEYGEAGKTPTDPMPMIQRLSLSLALTLNWGVRLKSQKDNLFDEITHVEEEISRFRSTTGNLQDFIPLLRLNPINMHSTKAKEMRSRRDVYLTNLNDGLDERIANGTYKPCIQANVILDEDAKLNKEELTSISLTMLSGGLDTVTTQVAWFVAFLSQNQEIQDRAVAEIRKFYDEQTPMCDENDDQRCAYVVALVKESLRYFTVLRLALPRASTRDVLYGGCTIPKGSIVFLNAWACNMDNKVWHDPDVFRPERWFEQPDAPLFTYGVGYRMCAGSLLANRELYLVYMRLLNSFRIEKHDTVDCHPVTGNSDPTSLVALPHRYRARFVPRHPAALRKAMDETRAMGGMDELVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4K6</accession>
    <name>A0A7D5V4K6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MIOX1</name>
        <name evidence="15" type="ORF">G6M90_00g110440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543815.1">
        <property type="nucleotide sequence ID" value="XM_014688329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4K6"/>
    <dbReference type="GeneID" id="26243202"/>
    <dbReference type="KEGG" id="mbrn:26243202"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI74434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="308" mass="35757" checksum="4C108500D35A8074" modified="2021-02-10" version="1">MAPSAIVEFPPATHDGQVLESLSDAIDDVNCIKYDSEAKFDSEKDKSQFRQYEDACDRVKNFYREQHKKQTVAYNLAARNRFNSASRVRPEMTVWQAIEKLNTLIDESDPDTTLSQIEHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLMLFFPELETQGQWDVVGDTFPVGCAFDKRIILPETFEANPDTKDPIYNTKFGIYSPGCGLDNIMLSWGHDEYLYHVVKDQSTLPDEALAMIRYHSFYPWHREGAYRELMCKKDHAMLKAVQAFNPYDLYSKSDNVPSVEELKPYYMDLINEFFPQKLIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4R3</accession>
    <name>A0A7D5V4R3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">rev1</name>
        <name evidence="21" type="ORF">G6M90_00g099810</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546368.1">
        <property type="nucleotide sequence ID" value="XM_014690882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4R3"/>
    <dbReference type="GeneID" id="26240791"/>
    <dbReference type="KEGG" id="mbrn:26240791"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12145">
        <property type="entry name" value="Rev1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="60"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="20">
        <location>
            <begin position="362"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="159"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="735"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1001"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI73339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1139" mass="126445" checksum="5608C92FBD886F86" modified="2021-02-10" version="1">MGSVLEKNSSLVRKRIEDHKFQDEEGDEYEGSKFGGFGDYFRRKKIKLQNLDADLRAASDKPQIFKGIVAHITGYTQPPLHVLHREIVEHGGGFIQYLDSKTMATHIIASTLPPKKSVDFGRYRIVKPAWIVDSVAAGKLMPWGDYRVLDEGPRQKVLRFDDERGMTQASPEARRGYKEQTDNSFYTSQFKSSTTDPSQSLSRFGEETPTPSKPSVSLASNEQQKPADRCQYLMTSPKSYLCRNMESQGVVTPTRHDTQNHKVMGPPEQSRGVVDTRSPSPVAEPAKEMTSEEHNAWLLSDPRLRKSSTANPEFLKQFYSESRLHHLSTWKASLKSAMQRLAAEKGLTQRMFKKKPGARGYIMHVDFDSFFCAVSLKKHPEYADKPTVVAHSSGPGSEIASCNYPAREFGVKNGMWMKRATELCPDLKVLPYDFPAYEEASRLFYDSILSIGGVVQSVSVDEVLIDATAVVYSTSDSQGIGIDEGNVWREQEKADEIAARLRESIKTKTGCDVSVGIGGNILQAKVALRRAKPAGQFQLKPESVLDIVGELTVEQLPGVSHSIGGKLEELGIKFVKDVRTVSKERLAGALGPKTSEKLSDYARGIDRTEVGEQPPRKSVSAEVSWGIRFISQQEAEEFVFNLCKELEKRLVNEQVRGTHLTMKIMRRCLDAPLDPAKHLGHGRCDTFNKSATFGVATHNSETIGKEAVAILRSFKFSPGDLRGLGVQMTKLEPIKAQQARPTESSQRTLNFGPFVGPSSAKKPSRTEAIDDIESPQRPKRSPGHGIDTDPIADDPLTPRKPKVHPAMALSKAAQEDAKANTPLNVSGTQFILPSNPDPAVISELPNDIRSRLMGQRSRQSPAPEVPRLEGPASMEALLPSQIDADVFNALPDDMKAEVLATYGRRPAVPQSPRRDQHLVQPRKQTTPTKQGGIRSIFGKVQRQRDAQTGVVQTNFRTLRPGSESPIVEEIEELDAEFLAELPEDVRKEVVADHRRRRMALRSGLDAPPRRHATSDTESVLPGGQRKITFPAPPRKVAFASSGVTSTREVKDMLDAWHTQTRHDGPHSSDVEVFDKYLQKVVKEERDLEKVVILIKWLHILVEQDGSPGRGQESWREAAKQVESAVQAAVKERGFGPLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4W1</accession>
    <name>A0A7D5V4W1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARCA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g112670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540334.1">
        <property type="nucleotide sequence ID" value="XM_014684848.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246928"/>
    <dbReference type="KEGG" id="mbrn:26246928"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="54537" checksum="BD0D6A6FFC905F60" modified="2021-02-10" version="1">MDTDLRPILAEASDFFPNLMTSGSFSSDQGLRLKQPESPSTQAPYLPSITQLNPGIYGNGNGNQRGSSVAQALSQASPTTQTSSIPCMSVSDDTRRVFPLEDVQEACLLRYYIEEISHWFDLCDESRHFHLIVPTRARDHPHLLNAIFAVAARHLSRLPQYKTPQGILYHGQLLPNLDEHSAVEYMLHCMPALRQFHDVMDDDYRDSIVATAVILRQLEEIDNEDDSPSPSGQPRSLLSGSGKQVNFLAIIDAVLRSPPSQSVFGRRSLMQAAYWMALRQEIYHSFTRLEAPQLILPPEFWHSASRANKTVMHLVQVAKWKWGDGSEHEWARLMDQHEHLEKHILFDIEPIYKKPADKSKGEIFPTVWYRSNIEVTSMQLGLLAKSVLVAENPQLRAQATSRSSWRHVENEVRLLLLEQCGIGLCNPASPPALVHATFGIQLYGDFFTDQYERRAIRMVVEKYRDTHAWPVQRLLDMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Y6</accession>
    <name>A0A7D5V4Y6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">37S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g110380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543821.1">
        <property type="nucleotide sequence ID" value="XM_014688335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Y6"/>
    <dbReference type="GeneID" id="26243208"/>
    <dbReference type="KEGG" id="mbrn:26243208"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18463" checksum="1C7FBBC7D71C3108" modified="2021-02-10" version="1">MSDLSQSMVFDMLNNKSNIDTSALSGQKFEPAQRREDAQEPYHFHVYSHKHNTHITCTKPNREPIISMSCGNIGYRKSRRGTFDSAYSLTKYVLERLIHTGWPIKIQRLELVLRGFGQGREAAVKVLMSPEGKVLREKIVRVADSTRIKFGGTRSEKPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5B9</accession>
    <name>A0A7D5V5B9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">J-type co-chaperone JAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">JAC1</name>
        <name evidence="5" type="ORF">G6M90_00g100310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546318.1">
        <property type="nucleotide sequence ID" value="XM_014690832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5B9"/>
    <dbReference type="GeneID" id="26240741"/>
    <dbReference type="KEGG" id="mbrn:26240741"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="88"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="264" mass="29130" checksum="C9BCE0404B6C4846" modified="2021-02-10" version="1">MRAISATQRICGRCRLHAQTTSPPVASVSLAAIKPRALTTRPRNPAAHQTRRFTQRPSLAASSSSSSFSSSAAAEANAAPKTAPSPPQTLYSFFPQTLPDGPPPNGHFPINLRSLRAEFLRLQSRHHPDLHPASSKPQAEATSAAVNNAYKTLSNPLLRAQYLLSLQGVDVANDETLKVEEPELLMVVLEAHETIEEARSPADLDGLTAENEERIRRCEEVLEEAFREHDLERAKREAVRLRYWVNVRGAVSDWEEGKPAVLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5M5</accession>
    <name>A0A7D5V5M5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g107210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544118.1">
        <property type="nucleotide sequence ID" value="XM_014688632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5M5"/>
    <dbReference type="GeneID" id="26243505"/>
    <dbReference type="KEGG" id="mbrn:26243505"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="37543" checksum="593B30B6B11B90BA" modified="2021-02-10" version="1">MSLPTTARGWSVRAIDKDSFDGLNFQESIPLQPLGDYDVLVKIEAVSLNYRDLAIPRGRYPFPMNLPVVPGSDAAGIVLAAGPKATKFAKGDRVCTLFNELHQSNPITPEAVESGLGGAIDGTLRNYAVFTEQGLVRAPASLNAIEASTLTCAPLTAWNALYGLQSKALKTGDWVLAQGTGGVSLAGIQFAAAAGATVVATTSSNDKIDFLKELGASHVINYREESDWGQVARDLTPGRAGFDHILEIGGPGSIAQSLKAIKLEGVITIIGFLSPSDMQPPLMDVLNHLCTVRGIFVGSRQQFEEMNRAIDSAKIHPVVDPNIFTLEDLKKAYQYQWEGKHLGKVVVKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V640</accession>
    <name>A0A7D5V640_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g113170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539787.1">
        <property type="nucleotide sequence ID" value="XM_014684301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V640"/>
    <dbReference type="GeneID" id="26247452"/>
    <dbReference type="KEGG" id="mbrn:26247452"/>
    <dbReference type="OrthoDB" id="4939806at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24359" checksum="BFA20A3C41F31A44" modified="2021-02-10" version="1">MVRMDRITLEKNYSWTSPARHSSLRRSFVSAKESFAPPAGSSPINARHYDAVPGIDPQSSCEHLQSVLKNGVGGSNLDSGDMISRIVSPEADLEGATIRVADDEETTGRIRRSNQKRKYNTTRTTGSGEHRIQKKRASVSGRQVFEYSRLGAIREGVDGRIQFKICWKPTWGTLEDLRGSRALKEAEELIINKYDKDTWDEEMNKSGRLALSTRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6S5</accession>
    <name>A0A7D5V6S5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g107200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987817.1">
        <property type="nucleotide sequence ID" value="XM_066131720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6S5"/>
    <dbReference type="GeneID" id="26243506"/>
    <dbReference type="KEGG" id="mbrn:26243506"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="61627" checksum="829049BD8826E1FC" modified="2021-02-10" version="1">MANFPLALAPGACLSCRQQKQRCDRVIPSCSRCVARVVKCTYTARDQAALRQIASVSQFAADTLVILRGLCPLDVSPAGERALLWAACARQSTFVDDADAPQASLSCIINDIFDSAGVHVVGTVRSYFDIAHHWLPILDRDNVLASTENFVAQKAVSAVEDDAFALMVVCMYLFITPPCQHANHPVRHTLYRTVKSLFSILQASSDTTAQVLLMQSGIILATHEIGHGMSKDAYETLIACRSLLQRINLHNHITNFAGQTGPHVSLNRLQLDLCLSAIILLDMTVVLSTVDHDLPQLVHPSQVPQDSLLHRASNEDIYGEDAVRNLFARAQHALRLGDMSRSIGSSTDLAQCEAIEKTIYGQIGSYISKTQGGRFPLCETVAMSLSTLMVLYRKTNYLTSAVGDAKSNMAATCAYNLIIDTCRVESELLQRHGWHNSRRPCFLGLCCLLAASVHLDKLCPNGLEDGDAQQLRQALTGFSSRWKLGGELSARRWTYGVLADRVKMCFWDSLETATGTGSNRGPACLGRDDWWNFSRRQLPGGSAVRANATWDETARRLGWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6T0</accession>
    <name>A0A7D5V6T0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">G6M90_00g105910</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987821.1">
        <property type="nucleotide sequence ID" value="XM_066131689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6T0"/>
    <dbReference type="GeneID" id="26247913"/>
    <dbReference type="KEGG" id="mbrn:26247913"/>
    <dbReference type="OrthoDB" id="5152880at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028960210" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="431"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="411"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="476"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI74152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="590" mass="64834" checksum="C75444F4F7919FC0" modified="2021-02-10" version="1">MRVFIFLWLVGTVAALADAVIWEGEGWYKVYLLERVLFPDDPNSWTTCEGCKRLGKRRSTNDAFTKAFAKELEARGLPTSTVSVAEFFVGIGTTNGHFRRFGSEDGGSEVKKKFLTLNYKMTDLLDEMRLQRAIKGTNNFKFAASKIIDHSNFPEADFNDGELFDVAKMQRLISARAEQLRTMAKEASLIESWVKDRANALEVENMYRNADQVRWKSDWVDKELKYGPSNSYKQIKTPRLVIFPNGTRPEKDLHPNRPPNTPDLEIWEEVDMDKTLAQGGQSSIVKDKTKAATKKAGTYGKWQGDPDPQKKATIHMETIRANSEMIPFHRNQKGEFLKDFGLYAPGLVSNKDRPGLGAWCTSWVPPGTHAALTRYYTDGGSSLIDTTLGTAENWLVQATAFDGIIATNVPTSTSTSSSSTSSKTVSTPKSTPATTTTTTTPTAKPSWTGPTAVSDLPQCGQTCINNMLAKHRELGCGDKGVACMCRAPNFNYGIRDCANGACSNEDRASTVISFETSYWCPSFMATGTNSPTQTPTPTPTATSDLPPCGQTCMNNMIAQYSQLGCRSLDSACLCKNANFGYGVRDCANGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YL73</accession>
    <name>A0A7D5YL73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sdnT</name>
        <name evidence="9" type="ORF">G6M90_00g010350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985736.1">
        <property type="nucleotide sequence ID" value="XM_066129687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YL73"/>
    <dbReference type="GeneID" id="26238926"/>
    <dbReference type="KEGG" id="mbrn:26238926"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="536" mass="60030" checksum="8722F60A62411524" modified="2021-02-10" version="1">MELEYVLAVSVAFAGLIWRAMSLAVLGIIAVTLHIVLYRLTLHPLAKVPGPKWAAISNFWYARQIAKGKMAQLGLEMHRKYGDIVRVGPNEVWFNTTEAFDQIYCTGKGFEKSDFYLATALTRPTIDWKFNANFEDTLDLLSERNMKRYRLQRRLIGRVYSAANVAKYEDALTAALERIVQRLNELEGKEIDLKEWMHIITVECLGATVLSWSPGLLRDGTDWGTLSHSFQGWRRKCLFGVFPTMKKMEQLSPSLGRAFASLWAVTYRPPPTFKPFFPGVVKNIVRRLTASLKPGTPKDNRVDLLNDLIQLRNDRPEFNEVYLRKMAVTNFGAGHETVASTLTASVAMIASHNNVQKQVFLEQRTAEADDALVYASSNRFTYTKAAIREAMRLYPVVPMSLPRKTPPTGLHVNGLSVPPNTTVGCSAIALHRKEDIFGASPDLYDPGRWLCAETVDETAAATSASVRMMDKYSLSWGGGSRSCPGRNLAELLVLKVIATLFRRFEVEVAIPPDADKEAYFLLVLSGVKVKFLPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMF4</accession>
    <name>A0A7D5YMF4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkaline proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALP_0</name>
        <name evidence="7" type="ORF">G6M90_00g028140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541347.2">
        <property type="nucleotide sequence ID" value="XM_014685861.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMF4"/>
    <dbReference type="GeneID" id="26245982"/>
    <dbReference type="KEGG" id="mbrn:26245982"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="6">
        <location>
            <begin position="32"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="19963" checksum="C8B00C248284EF7F" modified="2021-02-10" version="1">MRFQLTYKIKTAETATSITSRKGPDGLNTVQRLQNVMVDAWNQGVLIFFAAGNNAIEVSQDLYPYPMAISSPHITVGSLSENWDKAPHSNFGPLVDIYAPGQNITVLNRRSGVRAVDGTSFASPLVAGMALTLLAKMDPLPKAEDTARILATQILDLATEHKVGAIPGAGPAEYQRVAFNGGLDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN37</accession>
    <name>A0A7D5YN37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Solute carrier family 35 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g001860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542892.2">
        <property type="nucleotide sequence ID" value="XM_014687406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN37"/>
    <dbReference type="GeneID" id="26244265"/>
    <dbReference type="KEGG" id="mbrn:26244265"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52593" checksum="C7D6799727E61C59" modified="2021-02-10" version="1">MGRADNHSPILQSILRLFSAKFNHGYEPVDTQDPDGQEPTPGARIMTTINDHPENMAPNKSGLTAHSARAWSGHADDPFSDRGSGAARDGEPSPETAEATQGLYILESKSVHWWSYLATADFWIVVAIGQVLALCITATNTFTSFLQQENFSAPAFQTLFNYVFLAIIYNSIFLLRDGPRAWARVAYRDGWKYLIMAFLDVEGNYFTVLAYEYTNILSAQLLNFWSIVCVVIISFVLLKVRYKPFQIIGILVCCGGMGILLGSDYIVQRDSGTSGGGSKLKGDLFGLLGATLYGTSNVLEEWLVSKAPMHHVLAFMGLLGMIINGVQAAIFDRDTIAGSAWSGKVGGYLVGYTLCLTLFYTLAPLILRMGSAAFFDISLLTANFWGVIIGIHVFGLSIHFMYPIAFVCIIIGLTIYFLSGSVLGDSKKPWLGDNQEAGVAGIGTAKLRAINAARMASVEAEYGAAPPKTQMSARIRAIFGKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNY4</accession>
    <name>A0A7D5YNY4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotically up-regulated 157 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mug157_0</name>
        <name evidence="2" type="ORF">G6M90_00g025800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985869.1">
        <property type="nucleotide sequence ID" value="XM_066129957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNY4"/>
    <dbReference type="GeneID" id="26237447"/>
    <dbReference type="KEGG" id="mbrn:26237447"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF1">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028899544" evidence="1">
        <location>
            <begin position="24"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="524" mass="58802" checksum="7BF18D6A1A82BFF2" modified="2021-02-10" version="1">MRIPSLTHTGVAALVAILPATHASWQDYEAQARTPASCPDYTDYSQKPHAPYSQGPLKLPFMRPSEECRTFTSPAVEKVIRDMKARIRDADLARLFENTFPSTLDTTVKYFDPKVNLAFIVTGDITAQWLRDTGNQFAHLYKLLPQDDNLKALVKAIINTEARYIYQYPYCGSFQPPPESGLKPTVNDYAAKVNVNPPVDNQTVFECKYELDSLAAFLKISRSFYQNTKDASFINDNWEKAMNKILQTINEQSQSSWSDDWEFVSYYNWTGTAGSLSPPVPNSGNGEPKLANGLVACSHRPSDDLCVFNFITSDNAMLSVELNHIADMLDASRKLNQVSRQARQHARTIRNAVLHHTKTPNGIFAYETNGYGGQYIMDDANVPSLVSLPYLGFLPRSDSTYRKTKDAMFSRSNPYYAAGKKFQGIGGPHVNATYPWPMSQVSGIYGTDDDDEIKGRLALILENTSGLGLIHESVHIYNTSDFTRPWFAWANSYFAEMMLDLAERKPGLIFKDDTPYIVGGDDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRR0</accession>
    <name>A0A7D5YRR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar amino acid transporter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">avt3_1</name>
        <name evidence="9" type="ORF">G6M90_00g062920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542590.2">
        <property type="nucleotide sequence ID" value="XM_014687104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRR0"/>
    <dbReference type="GeneID" id="26244539"/>
    <dbReference type="KEGG" id="mbrn:26244539"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="351"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="702" mass="76134" checksum="441B0F6259E24F91" modified="2021-02-10" version="1">MSLPKDTPNLDPGLSSPFPGQPRSFSSSLPREELTARLAEPVLPAPPPVRGASPVPGGDALQATEAPFTGGSSTQGPGVSALAAALSNSLGQSPPRHGTPAARISSPPPPSQSPALPTRADTPTHYGSLDSRSRLGPGSATGPYEDHEIVKRHLVQPSDAENPTSEESSPRGTIKGKQPTDVGAGKVNEEEFSSLQLQGGDVTRGIYKWTEQAEAKSKLNRSKSYDHMRPEPEEEVTDISAIKVPGGFRRDHLRRRAFSPSGQHAELGSSGAGSPGTLDQPRLFTSSFLEFLSIYGHFAGEELEEDDENLGPNEIWDSGEDRGGGDEEPTEDSALLGKKKRKRKVRGGSGKNSPMNAALLLLKSFVGTGVLFLPRAYLNGGMLFSNLVLLFVSILSYYCFVLLVTTRLNVEGSFGDMGGILYGKWMRGLILSSIVISQIGFVAAYTVFTAQNLQAFIHAVSDCKASITIPLLILMQTAIFLPFSLLRDIGKLGFTALIADAFIMVGLAYLFYYDIITLNANGLADIIMFNQKDWTLFIGTAIFTFEGIGLIIPIQESMKHPTKFPRVLFLVMVIITVLFTVMGAVSYAAYGSKTETVVLLNLPQDDKFVNGVQLLYSCAILLSTPLQIFPAIRIIETELFTRSGKYNPWIKWKKNVFRFFMVMLCSAIAWGGANHLDKFVALVGNFACIPLVYIYPVSQIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS19</accession>
    <name>A0A7D5YS19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g041580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986375.1">
        <property type="nucleotide sequence ID" value="XM_066130285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS19"/>
    <dbReference type="GeneID" id="90967670"/>
    <dbReference type="KEGG" id="mbrn:90967670"/>
    <dbReference type="OrthoDB" id="10403691at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="178" mass="18455" checksum="B1B0CA38F8AD96BD" modified="2021-02-10" version="1">MAGVGVDTSPSSSLVEGVVEDAVEVVVGVIVDVIVGLGVGVADVVDDGFGLVVGLGEVGDGVSNGILEKVPGRGKLIEELARTAVGDCLFPQIVDEHILPSPKSSMEHSRSGVLYAKAHSKGNDMVDIDSKFSSVKSEPDASMANSSTMHKEFASLNRLLAITGNCTGVRPYRLMLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTR5</accession>
    <name>A0A7D5YTR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g058960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986671.1">
        <property type="nucleotide sequence ID" value="XM_066130673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTR5"/>
    <dbReference type="GeneID" id="90967822"/>
    <dbReference type="KEGG" id="mbrn:90967822"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="284" mass="32356" checksum="1E39CF138917FBBC" modified="2021-02-10" version="1">MSSQGMPNPTPLSHEAVMHDSQPVLNAFSPSTNKMSSKPHTEEPANDGQSLVCAPVDGEEEGDARAGLTEPHDWTNEQLAYFRHLLDIGTSWHRAQVKGWKPAWTEPFWTDTRTAYLTEVVSRSKTWDEVLARFAEKFQANKSAPATRSRVKKLGLNIDHLRTHQLFTKAEKDYFDELAESGFKGKKMYERFWERFGKRITGVSLARRLSARMKKKKEADPSLRVSNSRWTPEEASFVQECLDSGMRQAEIIPHFRRKFGDGRSDWSICAARGRLVKAEDAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUP9</accession>
    <name>A0A7D5YUP9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase DCR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DCR2</name>
        <name evidence="4" type="ORF">G6M90_00g084930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987500.1">
        <property type="nucleotide sequence ID" value="XM_066131260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUP9"/>
    <dbReference type="GeneID" id="26246042"/>
    <dbReference type="KEGG" id="mbrn:26246042"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="221"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="590" mass="65404" checksum="53A08DD6CD3F43FB" modified="2021-02-10" version="1">MTRRIVRTLTQLGAALAFTLIVVFFLDRNYRVLPNAIHGYMPTHHAGLVVTDVTLVQCSSLNLFSSCDLDPTTWHRIDKELYLGRAWTSTAYLYISRKHEEDLTSDDKVIMDISVGRLNPAQAQDAKSPKGNPEDWESRPGGLWIKRSGSKKSSDSDDVITDLDVLFGDDAVEARDGWAITGTQLLLDTGGPLLSIHLTVRRGAPKERKKPEPRIGHNGKFKIMQIGDLHLSNGVGECREPVPDGYAGGKCEADPRTLDFVNKMLDEEKPDFVVLSGDQVNGDTAPDAPTAMFKIISLLVKRKIPYAGIFGNHDDEKTMSRARQMALMESLPFSLSRAGPADIDGIGNYYVEILARSGQHSAVTMYLMDTHAYSPDERKYPGYDWLKQNQIEWFRKTAASLKKAHSEYSHTHMDIAFVHIPLTEYASPELPRVGEWKEGVTAPVYNSGFRDALVEQGVLMVSAGHDHCNDYCLLSLQNVTRHDAKPQPDQQPPPQIQKPALWMCYAGGVGFGGYAGYGGYVRRLRVFEIDTNVASITTWKRVEHGNTADKIDWQVIVDGGRPVPPPPPPPAPSDQPPAPPPPPPVQDVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUS5</accession>
    <name>A0A7D5YUS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g028850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541282.1">
        <property type="nucleotide sequence ID" value="XM_014685796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUS5"/>
    <dbReference type="GeneID" id="26245917"/>
    <dbReference type="KEGG" id="mbrn:26245917"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24895" checksum="572831A9B4CE75FB" modified="2021-02-10" version="1">MPKLLDFRCAVITGGGGGGIGKAMARHLVSKGKTVLLAGRTESNLQSAARDVGAAGYYLLDVGKTADISPFVDRITREHPELDCLINNAGVQRPLDILQDGDFVAKADQEIDINVRGPMHLTLGAAAAPADQARRRVAALLEHEPAHAAAAGVRVVEIAPPTVATDLHREREDPDDNKKEKNARALGVDEFMGEVARKLERGDEMISAGGGSDIVEKWYGMYGALYDETASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUX5</accession>
    <name>A0A7D5YUX5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g054770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540929.1">
        <property type="nucleotide sequence ID" value="XM_014685443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUX5"/>
    <dbReference type="GeneID" id="26246235"/>
    <dbReference type="KEGG" id="mbrn:26246235"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="256" mass="29378" checksum="A6EB619A4A981087" modified="2021-02-10" version="1">MDALDHWAPLYECDTCTREFGSWHAAQQHMDALDHWAETYLCETCDSEFYSEKAAKQHMQAKGHFKNYCLECDRYFGNANGLRMHLNSNVHRGHNVECPFCRTGYTTASGLSHHLESGSCPKAATVNREVILSMIRKRDPQGTITNKQIEWQNESSVKITYEANRLAWNGSAWECYICHGQFSTINGLNMHLNSPHHKGKIYHCPNKKGACDKEFVSLGGLFNHLESESCSYMRFEKVQKHVSNMFNGHRFIAFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVF1</accession>
    <name>A0A7D5YVF1_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Flo11</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g011660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
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    </feature>
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            <begin position="954"/>
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    </feature>
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            <begin position="1064"/>
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        </location>
    </feature>
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        <location>
            <begin position="1154"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1321"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
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            <begin position="411"/>
            <end position="444"/>
        </location>
    </feature>
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            <begin position="1071"/>
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            <begin position="1157"/>
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            <begin position="1312"/>
            <end position="1321"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI65245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1321" mass="142765" checksum="C4198E2EAE588863" modified="2021-02-10" version="1">MSPTMDANASRLPSGLVSPRHVRSRTQSISSDRPSTIGYGVGLPPVFISPPAAFIASSAASQIITNDHDSHADAWYDQNGIDPAAETATVSASALQLVNSFLDQLLFNVLQVSKSTALSALRPAVIEVLKPKLGRDVVSNADEELREYLGGANEEDYEQFQGPSSSRNWDGELVWKRTRLRCMVYSSLGDMEEEDEDAYMEEENLDIGAHEQISDTISAPVAIFLTSVIEYMGELTLTVAGQAAYQRVRSKIEKELKDGARNTSDPADRIVVTDLDMERVALDRTLGRLWRGWKKRMRTPANDIAGSLFPKGPPTPCKPGQMEIAHDALSPPKSATSDSGSEFRDSQEHFEDPIMEDVQPMDIPLPLGDNDVDEIEVPGLTHYSDDEGDDEGDDEMDDDEVQVRKRPKSLLISSSMFANGLPTPTKSQPHTPTVRSRQRSTSLPTPRIPHFPPKTQRHIPPSTSESEADQDTVAEIGVAMSTDGHGSLSEANAEPIATSDVPAKKDVDARSQSSGSDYDGTEEVAFEKAEIMTTSRISMSSSAQSTDSDSNGKATPMKRSSSVHSARIIDVPAPRSPARSRPTSLDATEQLRPVRVAGVASGFARTAASDDRSKATSNETPIKAAINALPPRSSHDKRKPSASNTAPISELEEEASQNFTRAVNQPDSSADATEMEAAGSTSSAMSQRRKGMLVTLNTKIQSSSKYEQSPVSARTVSLPATPASPDIAKGNAPDLPKKASVHSGWSSPKPETKSRLSIERTRTHESDELSLPAQQQNTSGSRQVSQAHTSVSSVSSGASRLKPVRTSEDSSSRSESVARNFEELIQSNQTITYTLTPENMRDIDAKRSLDSPVVTKFARRKSEDARAHQYSPKASPILTPSAAGNLPSPRLPPSPASPKIVESKAIINPAGPVPPAPTTITAPTARTNGATAREARVPSDSVSDFAEFIKSTGPAGETKSYTVPKLGSPPVSSDKGYRESRRASATSLANRLRYQPRDATVDSRVDNSDLIDFIRQGPPIAASNHRIPRHVAPFRTTMDSDQMSGAVGGKAIDANIPDIRSSRTSTNVTESSMPSMQSSVNSKSALIKHKTPKIPNKLFDDDDNMMPKPKTRRVRDPYAIDFSDEEGGVGQDDHILDTPKLPVKKEESLAEFLRNYEPPPEPVSAPAPRLPRKKASAPSLIGRFTRGGKDKEKEKDSASIKGMPESRSVSRASSGRGYIPIQVNIPPGYDKYNPMNGNIGAKRARGPSTTSSTAGRVPMKKFEPREAASKRSETADLAAFFRDSGPPLNNSPMVIDRRSSQQEDSGGLTKMFGRKKKPLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVV2</accession>
    <name>A0A7D5YVV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CEABS</name>
        <name evidence="5" type="ORF">G6M90_00g068660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="SMR" id="A0A7D5YVV2"/>
    <dbReference type="GeneID" id="26247247"/>
    <dbReference type="KEGG" id="mbrn:26247247"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
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    </dbReference>
    <dbReference type="Pfam" id="PF19086">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="38824" checksum="9FDC97168956312E" modified="2021-02-10" version="1">MEKQILEPQLSALRLPAFNVPWPGARSPHAEVIEARMIEWADHYDLLVNDEHRSRVIRARYGWLAARCYPNAAKELLQVIADYFVWFFLADDLFVDRVETVSGDTLRNLTAMIDVLDFNSAGLEPVWGELAWLDVCRRLRSLLQAEPFERFAQGMRLWATTAGLQILNHIRPKSVGIREYQTIRRHTSGMNPCTALSDAANNGSVKPYEFYQPDVQALVRRANNIVCWANDIQSLGVEIRQPGQFRNMVVIYAEQGGSLQNSVETTAARVDAEISSFLELADAVTARANVTLRGLVDGLKYWIRGYLDWVEHDTLRYVDKFAAVDADDRFLSTPQVASRHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW97</accession>
    <name>A0A7D5YW97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW97"/>
    <dbReference type="GeneID" id="26245281"/>
    <dbReference type="KEGG" id="mbrn:26245281"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="480" mass="51558" checksum="5B0269C0413EA937" modified="2021-02-10" version="1">MEPGIPMILPKGIVINTTDIYKEVASYPIVPAQKIWEYWHVYTTTNKKLKDPTARRLENFWWQVWGSDRRYLSGRALAKIYEDISLGPAIVPLHGPPNRWEGPGVPPLTKQLIVAHLHRGLDETKHRPEPPRIKSNDTSIKSLSSSASKPPPSHPILKKSKNPLSSGPKPTARFASPPESDDDGGRESDIPSSGSTAITGLEMAMSTESPPAARAVSAPENASPAGKQALNRKESPQLLPNSAVQPSSKDTAPTATTRSPTQLRTVSPIPEQPQDKAEYESTEPEDNVSTASHRPAVLSAKAAGKQPMPSRKIARKLSNLSQEPSRPPISTSLANSKARTTPDLRSPVSARSLSLTRTDTDNSSTTGSLTDSVSMAGRSLSQNGYARKGSLSQGLFTGALATTTNVAAKGQIIDQAGSLPTSGVIDPYVEDDNLASRPSATSLLESRMQPTQPSPAASVPMGRTRSQLTLLLEREKTKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXM0</accession>
    <name>A0A7D5YXM0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FUBT</name>
        <name evidence="12" type="ORF">G6M90_00g016350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548893.1">
        <property type="nucleotide sequence ID" value="XM_014693407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXM0"/>
    <dbReference type="GeneID" id="26238337"/>
    <dbReference type="KEGG" id="mbrn:26238337"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="52"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="564" mass="61597" checksum="E92F9F26EBFD2245" modified="2021-02-10" version="1">MTGLTRLLSRPVNKPYRTRDLDHTEPPFLDDAGFLAFKPDDIENPQNWSTPRRITVTISAVILVMNATFASSAPSGCIPSIAKDFGISTEAAALTVTLFLLGYCAGPLLFAPLSELYGRRWIFYISFTMYIAFNFLCAFAPNFGSLLVGRFLTGTLVSAPLSNAPGVLADIWSPLERANAMALFSTMVWIGPALGPVVAGFLELKKDWHWAFYVLIWLGAGTWLIMLTIPETHAPTILLHKAKRARKAKIPGYENVKAPAEKQDRSITSVFGVALTRPWVILFDPISLLCAIYLAVIYTLLYMLFSIYPIVFQERRGWNSGVGELPLIGTVVGAILGGSIVLFDTRRRSKKIERGEIKADDMEPEDRLPLAMVGGIGFAAAMFWFSWTAEFNSVHWIVPTIAGGLLSTFMLLIFVAYLNYLVDVYLMYAASAIAANTIARSASGAAAPLYTSQMFHALGIGGGGSLVAGVATLLAVVPFVFYKYGKPIRIRSKFAPTNTKEKNRVEDEEANATDFAIQSSSEVDSSTDVDSSHTSPVANEKTEERDVSSGGQVLAPNERKGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXN6</accession>
    <name>A0A7D5YXN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glnA2</name>
        <name evidence="9" type="ORF">G6M90_00g000880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985911.1">
        <property type="nucleotide sequence ID" value="XM_066129493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXN6"/>
    <dbReference type="GeneID" id="26244353"/>
    <dbReference type="KEGG" id="mbrn:26244353"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="143"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="501" mass="55263" checksum="E5C70672B941AF08" modified="2021-02-10" version="1">MTICQLPPSVALITRRSLLIPATTMGSQITASSLPQLLEHDTCVKLAGIDVDGILRGKLVSKKKFLSIAEAGFGFCSVIFGWDMHDQTYLKELKVSNAENGYRDILAIPDLSTFRRVPWEDNVPFFLVNFFDPETKKPIAPCSRGLLKTQLDKVHAKGYGAMAGAEYEFYTFRNPNSDSASPAGFLLQNPPHQLPSLTEGMFGYSLNRPVHNKDWYYDVYNTCARFSCDIEGWHTESGPGVYEAALEFGEVADMADRASLFKYVVKSVGINHGITPCFMAKPKQGLPGNSGHMHISIVDGDGKNLLARDTTDPDAKWNDIAALSDLGRHFLAGLLEGLPDIMPMLAPTVNSYKRLVENFWAPVTVSWGLEHRAASIRLISPPTSKPGATRFEVRTPGADSNPHFVLAAILGCGWRGVEKKLEIPCPPLALGQDTGGAGDVGERLAKSLKEATARFMRKDSIAREIFGDDFVDHFGGTRENEVRLFDEAVTDWEMKRYIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY95</accession>
    <name>A0A7D5YY95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GDI1</name>
        <name evidence="3" type="ORF">G6M90_00g023870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986045.1">
        <property type="nucleotide sequence ID" value="XM_066129914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY95"/>
    <dbReference type="GeneID" id="90967504"/>
    <dbReference type="KEGG" id="mbrn:90967504"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="51470" checksum="240D0D255BB664E0" modified="2021-02-10" version="1">MDEIAKEYDVIVLGTGLTECILSGVLSVKGKKVLHIDRNDHYGGEAASVNLETLFKKYGNFKAGEEPWTKYGRLNDWNIDLVPKFLMSSGELTNILVSTDVTRYLEFKQVAGSYVQQGAANKATVAKVPSDAGEALKSPLMGIFEKRRMKSFIEWVGTYNPKDPATHKGLDFNTCTMKEVYDKFGLETTTKDFIGHSMALYLTDDYITAKGQAPEAIERIRLYGNSVARYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTNVDELLYDGDKASGIKATMKTGAEDMKFETKAKLILGDPSYFPNKTKIVGHVLRAICILKHPLAGTNDSDSAQLIIPQSQVGRKNDIYIACVSSAHNVCPKGYWIAIVSTIAETSANHHLELQPGLERLGKIEEQFMGPPIPIYEPLEDGKKDNLFISKSYDATSHFETTTDDVKDIYRRCAGEELKVEGLREGLSVAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ43</accession>
    <name>A0A7D5YZ43_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-L-rhamnosidase rgxB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rgxB</name>
        <name evidence="11" type="ORF">G6M90_00g045350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986516.1">
        <property type="nucleotide sequence ID" value="XM_066130371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ43"/>
    <dbReference type="GeneID" id="90967694"/>
    <dbReference type="KEGG" id="mbrn:90967694"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028986898" evidence="10">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="451" mass="50456" checksum="8E5C3DDE11D250DF" modified="2021-02-10" version="1">MRLLTLLAALQWVLVAVAFDKWNVWLDHSDVLGDQWLGDTQLGLLALRIAEQEGRKLCILRPKSLKRDNAPMIMKTLNEVCREKSLVYMPGEVYNINSPMVTTNIVDVKIILTGRLQWSGNIDHWLRVSMPIGFQNQSTVWHFGGHNVLFDGYGIGTLDGNGQLWYNWAVSEGNLPHRPININFKGLSNSVIRGLRFVQSQMWTMAISHSRNLELSDIYVNSTSNSRWSTLNTDGCDTISSDNITFRRWWVANGDDAIALKGNSSFIYIYDSIFHGGQGIAIGSMGQFDGKYEYINNLYARNLTFVNTAHVAYLKTWAGVSRGVPPNGGGGGIGLATNITMEDIKIRRLRQQPFFCWQCENYSGWAGRDCNSSKFKMSRVTWKNVTGTVNKDVKDVGSFQCSSAAGGCDDFEVSDIDVWVDGGDKLDNWHCENVHGNKGFTCNDPPPQKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZL8</accession>
    <name>A0A7D5YZL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hcs1_0</name>
        <name evidence="15" type="ORF">G6M90_00g012590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549264.1">
        <property type="nucleotide sequence ID" value="XM_014693778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZL8"/>
    <dbReference type="GeneID" id="26238708"/>
    <dbReference type="KEGG" id="mbrn:26238708"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="206"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="224"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI64706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="688" mass="75724" checksum="857A5A3075B15CDE" modified="2021-02-10" version="1">MPSKDAVDVPSFASTQLALLDRELKSEVDETSQLISNHSPAGLQRAGLAITNLVVSSQRTGLGGKTVLELGPDSATSATGELPEHGVRTGDIVLVAEQPAGSAKKREVRELERKGSRGVVTKVQRGFVNVALDDGKDEVSFPGRVWLVKLADEVTYRRMNQTMEKLQGLVEAEYSSFMRVLFGLSSPSPLPQDLSRDPQAGDIEWTDPTLNDSQKDAIRFALASREIALIHGPPGTGKTHTLIELILQMVKRKQRVLVCGPSNISVDNIVERLSPHKLPILRLGHPARLLPSVLHHSLDVLTNTSEAGAIVKDVRAEMDAKQASIKKTKSGKERREIYSDLKELRKEYRERERKCVSNLISGSKVVLATLHGSGGFQLRNEEFDVVVIDEASQALEAQCWVPLLSARKAVCAGDHLQLPPTIKSLNSKANPRPKDERLPIIKGMTLETTLFDRLLALHGPSIKRMLTTQYRMHEEIMRFPSEELYGSKLVAADAVKARLLKDLEYGVQDNEDTSAPLIFIDTQGGDFPERSEEDDKDNPKKGRGSLHSESKSNEMEAALVLQHAGQLVGAGVRPEDIAIVTPYNAQLGVLAPLKEKFPGIELGSVDGFQGREKEAVIVSLVRSNPDGEVGFLGEKRRLNVAMTRPRRSLTVIGDSETVKRGSNFLKKWMEFLEDNADLRYPDISSIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z016</accession>
    <name>A0A7D5Z016_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541004.1">
        <property type="nucleotide sequence ID" value="XM_014685518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z016"/>
    <dbReference type="GeneID" id="26246310"/>
    <dbReference type="KEGG" id="mbrn:26246310"/>
    <dbReference type="OrthoDB" id="10303667at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="142" mass="15645" checksum="3D53E87CBC4E2B1B" modified="2021-02-10" version="1">MDSKFSGTLKRFGCEMVGRAASAVCAATVLVLTIATVAMKKDGEPLLESILIVSVLGGLWNAAYCVHPPIRASPIYRPAVKLQVDRLLCVLWVFSVPAMVTSYVYTKDNFRASKEGSFDIVRVLTVWFTVLGFLPQFWIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0B4</accession>
    <name>A0A7D5Z0B4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g039770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547330.1">
        <property type="nucleotide sequence ID" value="XM_014691844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0B4"/>
    <dbReference type="GeneID" id="26239893"/>
    <dbReference type="KEGG" id="mbrn:26239893"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20446">
        <property type="entry name" value="Tudor_SpSPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF2">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="275" mass="30523" checksum="24E4C62450380BBD" modified="2021-02-10" version="1">MSGVAAIEEERSQYQEQLDIILQQLRDDPDSAELQALQEELTNVIGLLDENIAELRPNQPSQPTPKEPSPPPQPEKWSRENHPAFKKAPPPPEEKEEPPVTYHVNDTVMAKWVSGDKNFYQARITSITGSSAAPIYTVKFKSYDNTETLRSKDLKPISNKRKADDPPPQPSAPGVVSSAGATMYPGAQHEAQQDAEAAQAPKPKKIKAKKELEAGKAKWQAFNAKSKFGKTNKKDSMFRTPEGIHGRVGFTGSGQAMRKDPTRSRHVYQVNEDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0H2</accession>
    <name>A0A7D5Z0H2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539961.1">
        <property type="nucleotide sequence ID" value="XM_014684475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0H2"/>
    <dbReference type="GeneID" id="26247181"/>
    <dbReference type="KEGG" id="mbrn:26247181"/>
    <dbReference type="OrthoDB" id="10298965at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="240" mass="25960" checksum="B8690CEADED4A7BF" modified="2021-02-10" version="1">MSSPHSSPSPAGSRSITPFTDLNTAVESDPEWVKVPEPRNKTKGRSSPFTEKHEPTIPSTTPSSETDELCRELSISLHVALKDLKHANTRGSNWTNGYVKTLRPNSPTGRDSASQAFSPLASSSWSDYQYGVESHCENCPGTGCGSTSEISAETAPINATNSNAVEMTTTHNVPEVTEIRYLDAETGKWQSIKTYSADILTQQTQPVIKLRRVNESTAASAEGRSAGLENRETNTASLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0R0</accession>
    <name>A0A7D5Z0R0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gsdA</name>
        <name evidence="14" type="ORF">G6M90_00g108880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987925.1">
        <property type="nucleotide sequence ID" value="XM_066131764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0R0"/>
    <dbReference type="GeneID" id="26243349"/>
    <dbReference type="KEGG" id="mbrn:26243349"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="189"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI74521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="496" mass="57046" checksum="30DA03A0C935C50A" modified="2021-02-10" version="1">MELKENTSIVVLGASGDLAKKKTYPALFGLYRNQFLPKDVRIIGYARTKMDHEEYLKRIKSYIKTPTKEIEQQLESFLGLCSYISGQYDKDESFEVLNNHLAEIEKGRPETHRLFYMALPPSVFTIVSQHLKKCCYPPKGIARVIVEKPFGKDLASSRELQKSLEPDWKEEELFRIDHYLGKEMVKNILILRFGNSFLGATWNRHHIDNVQITFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQVLTLLAMERPISFDSEDIRDEKVRVLRAIPAIEPKNVIIGQYGKSLDGSKPSYKEDDTVPKDSRCPTFCALVAYIKNERWDGVPFIMKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVMRIQPNESVYIKMNSKLPGLSMQTVVTELDLTYRRRFSDLKIPEAYESLVLDCLKGDHSNFVRDDELDASWRVFTPLLHYLDDNKEIIPMEYPYGSRGPAVLDDFTASYGYKFSDAAGYQWPTTTAAPPNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0T3</accession>
    <name>A0A7D5Z0T3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein rhp57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rhp57</name>
        <name evidence="9" type="ORF">G6M90_00g035110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546905.1">
        <property type="nucleotide sequence ID" value="XM_014691419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0T3"/>
    <dbReference type="GeneID" id="26239468"/>
    <dbReference type="KEGG" id="mbrn:26239468"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="114"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="474" mass="51132" checksum="BC7A69899F0A42FC" modified="2021-02-10" version="1">MTDLLHILPSFRTAPFGALLPIIEQHALSTTDLLALHPADISKQTNLPLLDLKRLIATIQVSLSDDLVPRHPLQQIVSSAPEHDHSHHEQPSESNSQDASKSPAIQPQKGNPSSPSFISTLCPQIDAALNSGIPTSSITEITGESGAGKTQFLLSLCLAVQLPPPHGLRKQALYISTESSLATKRLSQILASNPLLQDIDFADRPSLDNILSTVTPDLESQDHILEYQVPVLLSRHNIGLLVIDSVAANYRAEFERAGSSYGSNMAARSAELVRLGALLRDLARKHGIAVVVANQVSDRFSSSPAPLPRTMSYRTSTSAQESPLASRSMPPPPPQSTLASTPSSPLPFSFSDDAPPTHPALRLDHQQRWFTGWGDDPRSSHSLKTPSLGLVWSTQIGCRIALFKRPVYGRPRQIAAPIEADDDNIDRGATLRNWRRWMKVVFAGHVAASGQGVTGAKEFEVTTGGIACVPGKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0W5</accession>
    <name>A0A7D5Z0W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ATG24</name>
        <name evidence="15" type="ORF">G6M90_00g026610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547926.1">
        <property type="nucleotide sequence ID" value="XM_014692440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0W5"/>
    <dbReference type="GeneID" id="26237370"/>
    <dbReference type="KEGG" id="mbrn:26237370"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="58"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="52781" checksum="2119335CC5989647" modified="2021-02-10" version="1">MAVTDQDHDQDNFSSISWTEHDTAVNSVAGQHGHHDGEASGARRSGRELDPHGLGSEKLECTVGSPLKENDGSKDAFISYLITTHSTFQSFQKETTTVRRRFTDFVFLYKQLMRDYPATAVPPLPDKQRMEYVRGDRFGPDFTLRRAHSFQRFLTRLSLHPILRRAPILHSFLESPDWNATMRSRSARTSLSTDPSNSSGVFDNFADTFINAFTKLHKPDRRFIEVKDKSDKLDEDLGNIEKIVARVVRREADLETDLKDLAEQFQKLITLEPGVEPEVHAFAASIQDTAAHLHTLRDVTDQDYLGSLRDMQAYSLSLKNLLRAREQKQLDYEQLTEYLNKSTAERDSLQSGYASSGAGSFIRAKIEDVRGVDHEQARRERQRKLELRVEELTTEVERARATSDMFDDEVVREVADFERIKRAEFKTQLGGLADAHVGFYGEVVDLWERYIKEMDQESVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z173</accession>
    <name>A0A7D5Z173_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g080310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014683798.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247925"/>
    <dbReference type="KEGG" id="mbrn:26247925"/>
    <dbReference type="OrthoDB" id="4186099at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028894654" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26001" checksum="D8183CFB66E86DC7" modified="2021-02-10" version="1">MVNTFILSLAVIACLVPSISGDNCKPGLSYCGSTLLQIGNYSDQVDAALKAQSLNTSAQVTANTLFDCIGGPSGDIKVISYCYYGCTTVSVGNSDYCKNTGQAANSTSSATVLPSPLSTTTVVTYPSASPTTPTTSSNDSNGSYAAPIVGGVIGGVVALALIGTMVFLFFRNKRHRQERSDKVLVPSVGHRPIGQQKPLHVSRPPNSRDFGSTAFPIEDERPVYEVPGFSEPRIHEAPTDARQELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1C2</accession>
    <name>A0A7D5Z1C2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Negative acting factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g042760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986205.1">
        <property type="nucleotide sequence ID" value="XM_066130306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1C2"/>
    <dbReference type="GeneID" id="26240175"/>
    <dbReference type="KEGG" id="mbrn:26240175"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53648" checksum="C3BE48FD741700DC" modified="2021-02-10" version="1">MEFVVPLLNADTVPQHYKYAFEACALASLNNGVGNGNHFEKQALGKYTKALSTTFAALRDPEVAKEDATLAAVLLLGLFENITAKTMGMLAWGSHIEGAIQLAKARGRKQLQTKVGLNMFIAVRTQMIIHSLSTSKSPGMDVSWWIEDAVRDRHASECQRLCIKVGELRGEANRLLTTVPRTPDNMEIVIDMIRRCQAQDQACASWCKNLPDYFQCKTATWEDNVPNGDYTKAEVYPGRVDVYNDLWVATIWNMLRCGRIILNSIIVRCAAWVCAPVDYRTTPEYANAARTTVDIVTDVISSVPYQLGWFSKRRDLLERANLSTFACGEDDSSKGLSGYFMTWPLAFIHSLDYLTDSQRTWVRGRLQYIGSQLGVRYALLLTQLNIRIPSMLIFRDGLITRPFGIPGDFERQASKASRPTPSFYASPLVPQHETAEKAKLDQEAASVFTKAMKFSNNVDERRTKTWLEFQHVTTTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1X5</accession>
    <name>A0A7D5Z1X5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-interacting GTPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RBG2</name>
        <name evidence="5" type="ORF">G6M90_00g062800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542602.1">
        <property type="nucleotide sequence ID" value="XM_014687116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1X5"/>
    <dbReference type="GeneID" id="26244551"/>
    <dbReference type="KEGG" id="mbrn:26244551"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="65"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="292"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="371" mass="41290" checksum="7E5D6AA21AD1836C" modified="2021-02-10" version="1">MVNITEKIKEIEDEMRRTQKNKATEYHLGLLKGKLARLRAQLLEPGPGAGGGGGSGFDVSKSGDARISLVGFPSVGKSTFLSKVTKTRSEVASYAFTTLTAIPGVLEYGGAEIQLLDLPGIIEGAAEGKGRGRQVISAAKTSDLILMVLDATKKAEQRALLEAELESVGIRLNREPPNIYLKPKKAGGMKITFQTPPKNLDEKMLYNILRDYKMLNCEVLVRDENATVDDFIDVIMKDHRKYIKCLYVYNKIDSVSLDFLDSLAREPQTVVMSCELDLGIQDVIDRCWKELKLIRIYTKRKGVEPDFSEALIVRSNSTIEDVCDRIHRTLKDTFKYALVWGASARHIPQRVGLGHLVADEDVVYIVSGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Y5</accession>
    <name>A0A7D5Z1Y5_9HYPO</name>
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        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g089300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014686107.1"/>
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    <dbReference type="KEGG" id="mbrn:26245456"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
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    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
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            <end position="483"/>
        </location>
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        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="630"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="931"/>
            <end position="1003"/>
        </location>
    </feature>
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        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
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            <begin position="698"/>
            <end position="710"/>
        </location>
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        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
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        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
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            <end position="803"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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        </location>
    </feature>
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            <begin position="859"/>
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        </location>
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        </location>
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI71684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110141" checksum="145D67BF524C01F3" modified="2021-02-10" version="1">MGPWTTLLVTYLFGGVTFIPLVVLAILAHAHYTLPYRHDLVPPHGREGDRLQSDIVQPGDDTSALEAEKKKSPAETASARATRDLDVAAGYFAVCREYTPMGLNAKPIERSTPVGSTTVAPPSPSVYQTMYRSIFDRKPVAGPLDNNNTNNSMSQRPKKAGNVFYVVLRHGHIMLFDDEEQLEVRHVISLASYDISIYSGGDVTPEGELFIKRNALCLSRRADGHDIPDADGQTMKPFYLFSENCSAKEDFYFALLRNQEQTFGFDSNPPIPKGFEVKNIISLVQRLHSSEDHVHSRWLNAMLGRIFLAVYRTRDLEDLIREKITKKISRVKRPSFLANITIQKIDTGEAAPYFTNLKLKDLTVEGECVVEADVRYTGNFRLEVGATAKIDFGTRFKAREVTLLLAVVLKRIEGHILFKVKAPPSNRVWMSFQTMPKMEMVIEPIVSSRQITYTLILRQIESRIKEVFAETLVQPFWDDVPFFRTEHKMWRGGIFQGDDAVVKSSEDAERPQAVPNVEQPEKLDENEDLLNQTRPLEKSQTLPAMGQQPTSTGFFGRKLGKSANGSATSVLTTAIDSKALNSGHSTPRSLNIIKNSTDPVVGTETAHADLFKPSSSPPDHATNLMASLASRSQDASPMQVPEPSAKASPRAKRSSRSSTSSKEIESKEHTGDTDITPVQRAHRNTTSSVESLPHSEDSGPGSPTPSTTGSFKSHTESLGRNFFSRRDTTSTTASTESSSGGNLKRNTLAAVTNAAEQARQWGWNAIRRQKEQRQNGDKSHQVDLSQPMGRGQPLPPPGTPLPGPTNGGTRLVTAPAPKRKPIPSSSSIREQPQAESMDHDKENRSPQPPSLPQRRRRGASQQQEEVAEQSMLVVAAPDDSRPGTPSHEDKVDHDEAWGNSATKVEKAARPKMEMGVEVKKDLPVAVVEIKSGSAETSSSAVRESSQEPAIEGVEAEKESPLAALPAADVGIDDDDDISGWLEDDTLGDESIAEGLPVTTGEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z293</accession>
    <name>A0A7D5Z293_9HYPO</name>
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        <recommendedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g091440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z293"/>
    <dbReference type="GeneID" id="26245260"/>
    <dbReference type="KEGG" id="mbrn:26245260"/>
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    <dbReference type="GO" id="GO:0016616">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF2">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G13450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="27472" checksum="4E2DBEAAF0CB6ED8" modified="2021-02-10" version="1">MSTILVVGATRGLGASLVKQYAATAANVVYGTARSSAIPSGFPEHVKWLNGVDLAKSSVGDDIVKLLGDTKPLSTLIITAGHFSTEDISAEKGPNWDQELQMYTTSSVAPVFIVHRLVHAGLLHQGSKVILVSSEAGSIGLRHEKEGGGNYAHHASKSALNMVGKLLSLDLKEKGVIISIVHPGFMRTDMTKGVGYDKYWDAGGAVTSDEAASTLIQWTDHVDISKTGEYWAPRGPGDIGTVEETMGKNLETPLHLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2C6</accession>
    <name>A0A7D5Z2C6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g064040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2C6"/>
    <dbReference type="GeneID" id="26247173"/>
    <dbReference type="KEGG" id="mbrn:26247173"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="381" mass="42090" checksum="F3880A73115F7D1D" modified="2021-02-10" version="1">MSQPSRWRRPAQNFPLFPHLAIVPALLAIATAVALFLHSDVNAALLWSQCHSHALLPALSRVPILGTPACYLVSFFYAALDSFRSKAVMSVILSYVGALLTVSTVESARKVNEKNAVVSKPTLPWLVFNLLGGALVWQLVYAPAFILGAKAWPFPSTGRLITDEGHGDPPVARDEEERDPLQLDKGRQMKLVETIAIPIAVALGYYVPSTLMLSLNKPAAIGTWLFFPAYVSLIRQFVRYSLNKLRRFQDGPMIHMEANTKAFIAVYAVPVLCSLLAHGFIIGNLTKADDRQEVTRSTVKFIEIDSQFIGLTMLYWVFTEVGWRAPLAMVVASIVLGPGAGTVLGWLYREKLITSDMITQLLEQVNDEERGDVGEETPLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z341</accession>
    <name>A0A7D5Z341_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secondary metabolism regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LAE1_0</name>
        <name evidence="3" type="ORF">G6M90_00g004250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542077.1">
        <property type="nucleotide sequence ID" value="XM_014686591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z341"/>
    <dbReference type="GeneID" id="26245108"/>
    <dbReference type="KEGG" id="mbrn:26245108"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="367" mass="41734" checksum="0F2261CF65CD478A" modified="2021-02-10" version="1">MSSPKMPDKAKQSPSPKPLSPAGDPAPPLLADDRPTNTQIPFRWTDDDTDSALGDEGSILSSTVSLNESIYNYRDLHGRTYQNSSTTEYWGPNDDTQNLGLDIAHHFITLLLGDRLFEAPIPERPTKVLDVGTGTGIWAIDMADAYPSSEIIGTDISPIQPVWVPQNLTFEIEDAQLDWTFNPSSFDFIHMRALYGSIGDWPRLYHQAYTALKPGGWLEDFEFTITLHSDLPEIRDDPDHIFKRWGTVFMEAGDRMGKSLRIGMNGRMTRYMREAGFEHITQKYYQVPVGGWSTDYTYKQIGLYNLTFMEDSLEGFALFLLREIMGWEYARVQVFLAEMRTALRHTKSRPYYLVTNAFAQKPETATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3B6</accession>
    <name>A0A7D5Z3B6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g043920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547727.2">
        <property type="nucleotide sequence ID" value="XM_014692241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3B6"/>
    <dbReference type="GeneID" id="26240290"/>
    <dbReference type="KEGG" id="mbrn:26240290"/>
    <dbReference type="OrthoDB" id="5430750at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="742" mass="84772" checksum="0E632AAF9FE359E1" modified="2021-02-10" version="1">MASQLNVEELIGAAEHHHEQYLQTLRSIQNVVGQRARERADSPPPRTLSHPTFFSPEPHTPNLHLLSRLQRTRTSTLETTAERPSFYPSPKPVARSTISHDSEFIPDEELSFIPLLDAPSAGARPAEELAPPPADITSRTQKPLLPLSFSDDMLMRHLRETEFDGPTATVLEEVVRRRPDMDLAVPFRDFAAFERESYVSTTFEVYEVTADAEAKKISVDIDVQADVKYGGEGVPYQSPDGIVDAPTVWEAIKDVNSDGEAVGRITIVQEPTPLILAALHLTMTPHFDMGELLTHLLSEAPNRGRTNAIMHRAFERTSSVSPYPPSPLIPPALDTRHQPASSYANVRQRSFFFVFKYYTSVAEGLEPAPWQRFDKRPSDKRLGDHIDIAECSSVLALSLGGEPTKPLRMRPRRERAREGFLFDTFGPWQLLSIQSFPDDQHTVRGEDFQKKSFYNGPYAFLDLLTAEYRDAGRRNQILHEKITKLITPPTEFMFDRRLRDKLLFEDKHFTYIRRYFWAYNTLAVINTGIKAMVGAYFDTFTDDFWPGNHPVLWPHPSPSSPEGEAYLAKMALLRRELEKAVAELGEVLKRNERTRKEIENLRDQLFSGSSIKESRRAIDQGDNIRILTMISMIFLPLTFVTAITMVLVCIPFMALIFLLQTRIFTVVVGELYRFILRVVTFPYRMFTGALEQDAPDNRSVHLAKGRKRRLRMRVANEQPPVGSRWKWPWQKRWNGEGELGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3G8</accession>
    <name>A0A7D5Z3G8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g027420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547845.1">
        <property type="nucleotide sequence ID" value="XM_014692359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3G8"/>
    <dbReference type="GeneID" id="26237289"/>
    <dbReference type="KEGG" id="mbrn:26237289"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="86"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="234" mass="25335" checksum="7ED5E928FAED70F6" modified="2021-02-10" version="1">MKPLVAGLISAAAASAAFNPLAQQQPIMPGGDRLPAQPDNKSYAQETPPPPAIKFKTGSSPPPPPPKDQDAHENKYEPQAQPQVSLSDTIGPLRSISSFSSFTRLCESTSSLLADLSARTTVLAPLNSAVDSLPRKPWESPADYRALGSQAYDGTGGQDRANKNLLRFVEAHLVAQSPWPRGEKAKTLAGREIWWEEESDGQRVLMPDRVAVDRVASRVSNGELWIIRGVINYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3Y7</accession>
    <name>A0A7D5Z3Y7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">COY1</name>
        <name evidence="15" type="ORF">G6M90_00g089010</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987378.1">
        <property type="nucleotide sequence ID" value="XM_066131344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3Y7"/>
    <dbReference type="GeneID" id="26244730"/>
    <dbReference type="KEGG" id="mbrn:26244730"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="440"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
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            <begin position="150"/>
            <end position="238"/>
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    </feature>
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        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
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        <location>
            <begin position="424"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="527"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="587"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI72045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="735" mass="81805" checksum="98014BF4972801A0" modified="2021-02-10" version="1">MAQVVGAGPAAAEAASSAARPDAPTAEGAGNKFQHAISSWRSVDLTTLTANLDNTASEIVTYQRDSTVQRKELAQKTKDFRKLDDASKLTEIKGLLKVEAYQNFIDLLTNHSKSVNSAFLQAYTSISEAPDPYPLLEASVDSMLLSEETLPRLAEENKHLQENVSKLTSQLEDVESKLQSERTARKEIEDNLDERVKEVESSWNAVMEEKKDNWAAKENSLEEKVENQERLLNEMRASYEVNQRLGKAGEDQENHHAKASSAELEMLHSDIERTSTRLAEVEARNEQLRLELAQAKSSISIQPEKSLEDDPGYMRMRSENSSLIRKLDASRLEKESMKRSFDSQQRTMERETLHLKEEKETLKAKVQRWNDYEDIKQELEVLKSIEFSTGDDDEVRERIESSTDKGDSLEKLLLSRNKKLGDELTVLRVSHQDLQSRLEDLQEELSRTNAELEKSQNLNQKLEEDLEHMQAEGANAFPSGASVAGTYVTRAQTRKGRISPTSSIISGLDPRSTAGEREPMGGGSGILPMVTAQRDRFKKKNAQLEQELSETHRTAQQLRQEVAALQKDNLNLYEKTRYVSTYNRGGATATSSSAYSSNPNPSTVSIGGTGNPGMAMDRYRQAYESNISPFAAFRGRESARAYRRMSLPERVVYSITRMVLASRTSRNLFAVYCVALHILVFFSLYWLGSADLDKHASSLGSSAAAAAGAAAAGAGKAASGGANHGDWKQDSFNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4J5</accession>
    <name>A0A7D5Z4J5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g053650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4J5"/>
    <dbReference type="GeneID" id="26246850"/>
    <dbReference type="KEGG" id="mbrn:26246850"/>
    <dbReference type="OrthoDB" id="5413269at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="24131" checksum="C77B2A4A1A1AA553" modified="2021-02-10" version="1">MATYTISVINESALKQRFVLYQASPFGDNVDGFGNVWMQLTVNEGGDTQTVKITAEYFAWAGSTETPLQSGVVVSGGKSLPATLGKDGQTGSTFHTAVSELIRQFNVNIQEIDSSAPAGAYTIHTRDDFDVGDTRVLIGLGKKDQHNRSIPVASLNPLPNTRYNMTPILKGVISVDTSSQIGEALSYRAISDLPGVIDFSSGKGQGKFTAVVIFTPKGKFEVDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4U1</accession>
    <name>A0A7D5Z4U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnh202</name>
        <name evidence="9" type="ORF">G6M90_00g037370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691612.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26239661"/>
    <dbReference type="KEGG" id="mbrn:26239661"/>
    <dbReference type="OrthoDB" id="29098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13383:SF11">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="40"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="129"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="442" mass="48565" checksum="E0D4A95D5818159A" modified="2021-02-10" version="1">MPRTRSTKPAASESTDTPAATLASKYTLTPRDGSSPGIFILPKTATPEARIVTLPHPRNGKPSRYLICPKTGIHEFTKISAPQSAPRSWLIETRADSGDDDTDSKEADPHVDIVSSSDMFVATTIDALFLVLPSLVDATVQKGSDEKKRLFLSSDDHFDKLPEESSHLSEILQWEATRALIESRMEIICDTVEAGDEKMFRLSEKKLVATILEKAKRMSDGGLPATLEEKFVKRALEAPILLHRSTLAAKVSENQAAAEVATESEVSTPVTDSAQSQSTTVTTDSNSSFVSQPSTAATSFVEDGQAEDAAMTAIQASAEVTALQRLRVAFDFICSRYVPTATAEQLKLHLSQQDMCSVDFSPLDKYRSKLAELRAEAVAATSTADYSRKRMGDEEEDALRQEKKRKLEEEKKRKANESRGVRELKKVNTSGMMKLSHFFKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5J6</accession>
    <name>A0A7D5Z5J6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetochore protein mis14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mis14</name>
        <name evidence="1" type="ORF">G6M90_00g047550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986406.1">
        <property type="nucleotide sequence ID" value="XM_066130430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5J6"/>
    <dbReference type="GeneID" id="26242214"/>
    <dbReference type="KEGG" id="mbrn:26242214"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="221" mass="24188" checksum="B1D86381870D2E13" modified="2021-02-10" version="1">MDQDSAASQAQRKIELQSPQDLAYLVAKVRGAAAARINEAFPHVPGQGEDELRNQIESLVNEYIDKTFTLAAPNLSINGLPVSSTEYLSPSPATRDTHEPFDARKRQRVAELISQEEKLLEEVAALKRSVPGKAADEQAARVRDAIRRDEETVEARRAAVAVESGKEGGSLRVDRLERQDGVEAGFRGAVEALGRLKRDMPSAVAKMERARVAGEYVLDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5Q5</accession>
    <name>A0A7D5Z5Q5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="6">HMG-CoA synthase</shortName>
            <ecNumber evidence="6">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hcs1_1</name>
        <name evidence="9" type="ORF">G6M90_00g036570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547048.1">
        <property type="nucleotide sequence ID" value="XM_014691562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5Q5"/>
    <dbReference type="GeneID" id="26239611"/>
    <dbReference type="KEGG" id="mbrn:26239611"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="8">
        <location>
            <begin position="176"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="453" mass="50051" checksum="FC2C594C736AE0F4" modified="2021-02-10" version="1">MASRPQNIGIKAIEIYFPSQYVEQSELEKFDGVSAGKYTIGLGQTKMSFCDDREDIYSLALTVTSNLLKKYNIDPNSIGRLEVGTETILDKSKSVKSVLMQLFGDNANLEGVDTVNACYGGTNALFNSVNWVESSAWDGRDAIVVAGDIALYAKGNARPTGGAGAVAMLIGPDAPVVMEPGLRGTYMQHAYDFYKPDLTSEYPYVDGHYSINCYTKALDAAYRDYCKRESKLANGNANGTDASKTPLDRFDYLAFHAPTCKLVQKSYARLLYHDYLANADAPAFAEVAPELRDMDYEKSLTDKVVEKTFMTLTKKKFQERVQPATQVATMCGNMYCASVWGGVASLLSFIDPKALEGKRIGVFSYGSGLASSFMSFRVNGNVEAIAKNLNIPSRLEARRAVPPETFDAMCELRHQAHLKKDYTPKGEPSTIIPGTYYLEKVDDMFKREYKVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6D3</accession>
    <name>A0A7D5Z6D3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g060210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986933.1">
        <property type="nucleotide sequence ID" value="XM_066130694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6D3"/>
    <dbReference type="GeneID" id="26243003"/>
    <dbReference type="KEGG" id="mbrn:26243003"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="156"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="350" mass="39459" checksum="4F3EA41C0ECDDD14" modified="2021-02-10" version="1">MATEASTDAAGEDLVCARATPKQRTRHFENTSQMWAAPLSLPQYLHMQNQLAKSADNVATTQYWVLFKPSDPDTIMSSCSVYLREAIVNSGRGMEPVKAAVITDIFTHSEFRRNGMATRLLTKVKEALDGMEKERKPQTAHQQRISYGSKHMVKPPDDEEVRQLSPEDLAELCLQEVNTAKLQLSALRVTQKTFAQVLGTNDVLKWHFVRSLILRRHLGSTKSQEKTAMNGVLYQNMRGITAWAWWVHDYRSRKLFIGQIGTARLQGMEEPIAKILHVAVAEACAHGLREVVMWEPTAQVAEAGGLLADRLGAGVQVIFKERFDDIPCVRLHEKNEREAALVSPQFYTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z719</accession>
    <name>A0A7D5Z719_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g106820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539897.1">
        <property type="nucleotide sequence ID" value="XM_014684411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z719"/>
    <dbReference type="GeneID" id="26247336"/>
    <dbReference type="KEGG" id="mbrn:26247336"/>
    <dbReference type="OrthoDB" id="4934586at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028928342" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="594" mass="66060" checksum="8449913ED0C03C18" modified="2021-02-10" version="1">MLLNLVPSALSALCLASTAIAGTIRQRDSGPSLGHARDLFLRRILADSPEYGNFRNHAPTNHDELKVGIIGGGVAGLYAAILLESLDIDYEILESSKRIGGRVFTHRFDQKAWEASKPGQPNYYDYYDAGAMRFPGMDWMSRIIGNASNSLIPYINSRLKPGDQPVKLIPYVFQANNTFRLFNDRLVYNQDTPSARTFGVLGFEGGTIQNNSFADTSPGAVFSDAVSDLVHSLEVNFEHGFKKLMQYDQISVRQYLATKGYSSQQIDWIETVNDATTHYNTMSLSEAVIEEWIFSEAPLDSWFCVEGGMDRITRGMASIINKTVETGKRVTAIKKAGTDALNVVINDTETRTYSHVINTVPLGAMQVMDMTDLNLDYRKKLAIRKIQYDASDKLSIKFKNRWWEHLDSGSFQGGQSFSDLPIRRCVYPSYGINTPDAPGTMIASYTWAQDSARLGAYCSGDAKQNLVDVALRNLAAMHNVTYDYLKSQYVDSHHWNWYLDENAVGAFALFGPGDLSTTMPDLMQPGAHGRLHFAGDALSSGHAWIIGAVNSAYRTVAEVLAVEKMDGKLAELVDRWGVIEEIDIRWYANGTMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z750</accession>
    <name>A0A7D5Z750_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ndufb7</name>
        <name evidence="13" type="ORF">G6M90_00g080040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539520.1">
        <property type="nucleotide sequence ID" value="XM_014684034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z750"/>
    <dbReference type="GeneID" id="26247684"/>
    <dbReference type="KEGG" id="mbrn:26247684"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI70927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="86" mass="10143" checksum="21DC1B489B62831F" modified="2021-02-10" version="1">MASDAATETRAATREEMRDARLPLAYRDSCAHLLIPLNKCRKETWYAPWKCSDERHSYEKCQYVEFKKRVAKMDELRETKGGERTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9M9</accession>
    <name>A0A7D5Z9M9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g075450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545553.1">
        <property type="nucleotide sequence ID" value="XM_014690067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9M9"/>
    <dbReference type="GeneID" id="26241586"/>
    <dbReference type="KEGG" id="mbrn:26241586"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="30381" checksum="028DF7BA109F7829" modified="2021-02-10" version="1">MGFATGLTGGVTLTLSLAYLSVLAHQRSREEQGRSLRSQALAIQSLIDPIPQPLPPTRSEVAAAKRAEAFEVAKDRWNEEVENAVKWVQHTDWDEVREGLEDRIGALWDRAFGESIKDSASKAKSEVQSVSKKTKGEVESAAGKIASKAKGAFEKAKAEGEDFEAKVKDNALQARLVAWREAQKAENEARQKASEAQGAVASALEKGKEKADEVVGKVKSAVGLSGAGAAPGTLALPTSNPVAKALDQRFERVGSDKRTVAEVLKERYTSMDKRDNTVLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA06</accession>
    <name>A0A7D5ZA06_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g104310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987549.1">
        <property type="nucleotide sequence ID" value="XM_066131641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA06"/>
    <dbReference type="GeneID" id="26245677"/>
    <dbReference type="KEGG" id="mbrn:26245677"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="86562" checksum="BE082EA40F2BCAB9" modified="2021-02-10" version="1">MERPAPLIGLRSFGGIRNGPDFKNGDPLLPYSEKPLQKRVPRIKAVFSHCLYKRVLVWAVVSLVLVTLFLSQSRRVSLSHVVEYAKGAGKDTSAEIDITNVNDGSQKPAVEVQVDELDREEDEKEREEFEKEANEKPWLRFPHLDGYFHGLKTLVKASELVPEYPNTTDAAPLPAPPVNNGRLLQPTAYNPYTTAGKHIKTCYLDKNRKIPAPDVYAYNGVPQHMPDAAFGSYEIFGIRDDICFDRFGRFGPYGLGYGKEEGGLGVGQDTEDSHNELIWATSGKINYTHVDWGEAQDQCSDANKHRLLAPVSQSGELPKSPGDRKGKKPRQAVVVRCYTDFQWTDLAVVNFRALITELSLKSGGEYTVHILLHVLDNDEPIWADDGVVQRILDSHIPAEFQSLATLWSEAQMELFYPGDFQDTYNNPSSAPIHGVYRSAHFPLQVFASQHPEYEYFWNWEMDLRYLGNYFELLDRIGRWADDQPRPLLWERNERYYIPSYHGTWENFTKTVEIDLVQSGRQAVFGPVDHEDRKSLFFEERGERALPDSCGAGHKLTQCGVGEGADLITFNPIFDIAYSGWVFSNDIVGYKNPSYDNPPRRSSIVTAGRLSRRLLMSMHEEVWRHHRTMFAEMFPASVALHHGLKAVYAPHPVFLDRAWAPAGSAVDAVFNGGRDRSTSGLNSPFYFFNEHNHKGTSFYYNSEFPSLLWKRWLGYAQMDGRGPFGGRRGAGTLRGGYEEESWSDSTGRMCLRSMLLHPIKSEGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBR3</accession>
    <name>A0A7D5ZBR3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GFA1</name>
        <name evidence="13" type="ORF">G6M90_00g098990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546449.1">
        <property type="nucleotide sequence ID" value="XM_014690963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBR3"/>
    <dbReference type="GeneID" id="26240872"/>
    <dbReference type="KEGG" id="mbrn:26240872"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="11"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="388"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="560"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI73908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="711" mass="78987" checksum="A2CD78BB19214523" modified="2021-02-10" version="1">MNANSFSPQNSGIFGYINYLVEKDRKFILDTLINGLSRLEYRGYDSAGLAVDGDKKNEVYAFKEVGKVAKLKALIDESNVELTKIFDSHAGIAHTRWATHGPPSTVNCHPHRSDPTWEFSIVHNGIITNYKELKTLLSAKGFKFETETDTECIAKLTKYIYDQQPQIGFTDLAKAVISELEGAYGLLIKSVHYPHEVIAARKGSPLVIGVKTQRRMKVDFVDVEYADDNTPLPAEAASQNVALKKNATDFLSPSNSLLGAPDKSLLHRSQSRAFMTDDGMPMPTEFFLSSDPSAIVEHTKKVLYLEDDDIAHIHEGSLNIHRLKKADGSSNVRAIQTLELELQEIMKGKFDHYMQKEIFEQPESVVNTMRGRLDINAKTVTLGGLRSYISTIRRSRRIIFIACGTSYHSCMAVRGIFEELAEIPISVELASDFLDREAPVFRDDTCVFVSQSGETADSLMALRYCLERGALTVGIVNVVGSSISLLTHCGVHVNAGPEIGVASTKAYTSQFIAMVMFALSLSEDRASKKERREEIMQGLANVSSQIKTILELDKPIKEMCEKVFRNQKSLLLLGRGSQFSTALEGALKIKEISYLHCEAVMSGELKHGVLALVDANMPIIMILTRDEIFKKSLNAYQQVIAREGKPIILCNPDDPEFKNSEAQKIEIPKTVDCLQGLLNVVPLQLIAYWLAVLEGLNVDFPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCE2</accession>
    <name>A0A7D5ZCE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EPL1</name>
        <name evidence="10" type="ORF">G6M90_00g096420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546692.1">
        <property type="nucleotide sequence ID" value="XM_014691206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCE2"/>
    <dbReference type="GeneID" id="26241115"/>
    <dbReference type="KEGG" id="mbrn:26241115"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="523"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI72789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="563" mass="64439" checksum="29A9EC4524C92EC3" modified="2021-02-10" version="1">MSSRKVRVKKLSVKTPLPVLREDQIDPSEYEALSSDNQISTGVEHAEEKEYHLQSILKDAGTSNTQEIPVPPPQKSDINYDALYLSNFHQPSSYIRFSQTVEECIGCQYDMSTEDTEFLKSYNGKSPTGGPLSEDDFERIMEVFEDTAAEQTPFASVDNTIVGYDMMVPSLNHLNSTSILQHAKAIYEYWGNARQEKGNKPLHPTLKFEIHQETDDTDPYVCFRRREARQTRKTRARDNKVAETLKRLRRELEDGRQLVLLSFEREMMKREVLHMDRAVFEERARLKQMKLRLGIKGEDEDLVNQKPQKRKPAEPSSVQRQQATQLRAPVRSDGRSLEQDLVSLADQLAQKENELREEIENKVQNHRRWNQNHIDLTRDPLSPVKEQGTELKFRPAKTQYLMTPPASISSEEMDVDEVQAEPMDIDKPHPLPVFQFKAGTISQDQPQANQPSFRRRIGRLQRLWIDRRGMATPPRQESSDYSDRWKYDSDDEDVDPPVYEVDPFDTRAIKFRATIPLSPYMFRGGRPSIAPEAAHAAAAAQAASNRALPQPPPAAAPQAQATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCG0</accession>
    <name>A0A7D5ZCG0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g097620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546579.1">
        <property type="nucleotide sequence ID" value="XM_014691093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCG0"/>
    <dbReference type="GeneID" id="26241002"/>
    <dbReference type="KEGG" id="mbrn:26241002"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="554" mass="60487" checksum="55F270F23D58A447" modified="2021-02-10" version="1">MSQFQDGTNQPGHGRDDPFWAPGTVNLNELGESGTGVILHPIPTSDPNDPLNWSAWRKAVNFTIVSFYVLMTFVLLDISFTAWGAYQEELGFSIGDLNAATAFNYSGLAVGCFIFVPLVQKYGRRPFYILSTSIQVAASIWAARTQTRADLWVSNLFAGLGGAISESIVQITIADLFFIHHHAVMNGCYLFIVATGAFLGPVAAGYVVQSQGWRWIWWWCTILLGVGLVFILLFFEESKYLPAIEGRAQPPNPATVDGQPGQYGPETTPQEMLSSSSQKDVGKLVERTKSNVVLDAAIPMKPISKRLALFTKSDGSIYGDILQPFRLLFTFPAIAYTALTYAVTLAMFAIVTSVQATYLLEPPYNFTPSGIGLMSLAPFIGTFPGIFVGGYLNDKSIIWLSKRNHGVYEPEMRLWLALPSAILMPSSLLMVGLGIAYGTPWPLIAVGFGILGFNLGVTGSVALSYAMDCYHDIIGNAMVGIVFSRNVLSVVVLFTLTPWISGMGLRNMHILVAILCFVILLIPAMLLVWGKKARIALANTYLAMAQKQPTSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPH5</accession>
    <name>A0A7D5UPH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g001270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542944.1">
        <property type="nucleotide sequence ID" value="XM_014687458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPH5"/>
    <dbReference type="GeneID" id="26244317"/>
    <dbReference type="KEGG" id="mbrn:26244317"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="27032" checksum="0E0A80A698337C1C" modified="2021-02-10" version="1">MASPKVFIVTGASKGIGAAVTRYLLDQSHKVVVTARSAEPLEGIKNAYPGQVEYVAGDMTSPEMPDKLTSLAVTSFGKLNGLVINHGLLVSSRLENTSIDTFKNLYNVNVFSCLAMAQAALGELRKTKGCVVWVSSGAALKPYTGWSAYGSSKAALNSLSSHLAFEERDVTSITVSPGRVDTDMQVQIRSSGQQSMDKAQYDTFIEAFEQGKLLKPEQPGNVIAKFVATPNRELSGKDLNWNSAELASYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQC7</accession>
    <name>A0A7D5UQC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g019710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548571.2">
        <property type="nucleotide sequence ID" value="XM_014693085.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQC7"/>
    <dbReference type="GeneID" id="26238015"/>
    <dbReference type="KEGG" id="mbrn:26238015"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="11">
        <location>
            <begin position="2"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="589" mass="67469" checksum="9F72007106EFBD28" modified="2021-02-10" version="1">MVLADVLKRWQQIKGKGTFFLTGTDEHGMKIQRAAAKEGIAPKEFCDNYSNKFRELAAAGDISHDAFIRTTDLEHKEAVSEFLLQLKHTLPEHLGLYKGTHEGWYAVSDECFYPEDLVRPDIVPQTGKKIMVSDETGSEVEWVKEETWFFPLTKYKDALLKFYDENPNWITPAHRMNEVRNWVENHLEDLSITRPAARLSWGIPDPEDRSQTIYVWVDALINYITQAGYGRKWHSSSDNMGLWPADLQIIGKDILRFHAVYWPALLMALNLPLPKQLLCHNHWTMSNRKMSKSLGNVVNPFFAVQRWDIDPLRYFLMRNGSFTKDMSYSNQLIGSVYAKELQANIGNLLYRIARPKVTSKWSTLEAVTAFRQGAFEEIRDHTSQQPFLSLDDHLEKITSAYYEEMEKYNTGGAIREVFNLLRETNRYVSDTEPWNLVKNSNPQSRILLNLVIYNCAEALRIAGILLQPIMPTKASLLLNELGVREDRRTLEFASKGKDPEYGTEAQTGDSAARLKKWDTIFPPTPNANDSDAEIMEQLSSALHDKTKNKMNQVAELLAMEARMGEEAVAKMLAEMHAARLKTAKKTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR53</accession>
    <name>A0A7D5UR53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Y+L amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Slc7a7</name>
        <name evidence="7" type="ORF">G6M90_00g003070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542776.1">
        <property type="nucleotide sequence ID" value="XM_014687290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR53"/>
    <dbReference type="GeneID" id="26244149"/>
    <dbReference type="KEGG" id="mbrn:26244149"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="607" mass="65368" checksum="7C2388EE86949E56" modified="2021-02-10" version="1">MSPYAVQSQSRDSLELASLASSSMIDGGAVSEVSSRPSISSSRRLSLVEEEDPLDDGNPAGRLGRSYSVSSTFDFAANLFPLSSTTGAGGYAPVGAPTSGARSGGALGGGSLEKHKTLTYLNGLSLIIGLIIGSGIFSSPSQISSKVGSPGAAIVVWIVAGILAWTGAASYAELGGAIPLNGGSQVYLSKTFGELAGFLFTWTAVLVLKPGSAAIIAIIMGEYFARAIIGADAEDVNPWVSKSVALLGICTVTCFNCISTRMGTRINDVLMFLKFVALLFVTVVGIIVAVKGYTFNGEKDNAWKPQDWFKDTSFDLSNWAIALYGGLWAYDGWDNTNYVVGEFRNPSRDLPRVIHSAMPLVIVSYVLANVAYFLVLPVEQVNGSNTVAVMFGSKVFGSIGAVIIALMVSASCLGALNSSTFTAGRLVYVAGKEGYIPSIFGKIGVHSQDPSLTTQRTRNWFSKKIHRFVGDDEMGLFFTPIYALILNGFITAGYCVVGEFPTLLTFYGVAGYTFYFCTVLGLIILRVREPQLERPYKTWITTPIIFCCVSLFLLSRAVFARPVQTVAVVGFVVAGIPVYFWRIRGRDRFRKPGDDGGHRPWWRFWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URM7</accession>
    <name>A0A7D5URM7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and KH domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ANKHD1_0</name>
        <name evidence="5" type="ORF">G6M90_00g002420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542838.1">
        <property type="nucleotide sequence ID" value="XM_014687352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URM7"/>
    <dbReference type="GeneID" id="26244211"/>
    <dbReference type="KEGG" id="mbrn:26244211"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="345"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="887"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="920"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1063"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1236" mass="138418" checksum="B909946B4C89A2CD" modified="2021-02-10" version="1">MSRDDYTIGWVCALPLELAASKIMLDQVHDLLPTLHGDTNSYTLGSIWHHNVVMACLPISQVGTNHAAIEATNMKRSFPSLRMCLVVGIGGGVPSKADVRLGDVVVGTRIMQYDKVKTNPEGEERTEVYKLIPRALGTALSHFAAEDKYTPLNSRFSSILQEKLANENHRKFRPPNLEDRLFQANYEHISSEASCDRCDSSRLMIRGQRKTNTVVHYGGIASGNKVMKYGRKRDEIAEELDVICFEMEAAGIVDVIDCLVIRGICDYSDSHKSKEWQDHAAVAAAAYAKGFLGMIPMTEFQSTTTNLSRSPQHIPREGQNAMLASLRFNSMSFRKHAIEKNHDKTGQWLWNHPSFQEWLDPALLSRHPGFIWIRGKPGAGKSTLMKFAWLQTQREYQQACRDRKMIVASFFFNARGETLEKSASGMYRSLLVQLLEHFHDLQRVLDSRDLEELLNLDSYPLVVLKDLLQDVVSELGNRAFFGFIDALDECHELQLMDMVRYFEELAEHATQKSIPLRICFSSRNYPYINIQRGVELRLDYQSGHAQDIANYVRSELRIENPTLHEQLVFQILKKSAGVFLWVVLVVDILNKEERDGRPAFTNRLSELPSGLSDLFESIIKRDNDNVDDLKLSLGWILLAPRPLELEEFYHACWHFKDPMLAKQYTKDRGEKYVLSSTKGLAQVAQSTPPIVQFIHESVRDYLLKDDGLRKLWPNLPFKWKDMRHDQLKHYCCRYIQHAINSAHINSPDVENDDISKRLPLLRYVTQNVLHHAENAADSICQGVFLEKFPTAQWASLDNMYEKYNIRRLSPKVDLLYILAQRGFPNLIRTRLQNHPNILIRGERLKYPLFAALANGHKDAVAALFNLPSTIYDGEDITAGVNYKKDYHGRTPLSWAAQEGKVGLVKLLLLAQADVNERDNAGQRPLFRSQPKRHFPVAELLIKAGADVNEKGYMYTNGNSAMRVTPLMHASAENDEIFARFLIQNGAKVDTICYEGEMGVVETALTIASRHGYEAMAKFLIENGALDGDWDKDINALAPAAENGHIGVVALLTENGIHPYTKRCGGFALVKALHYGHVAIASLLISRGADVEFLTDVWDKPSSCSPLAAASSNGHESLVRLLISKGARIGRPCASFFVKSPLLGAACNGQEAIAKLLIREGACVNEVAGSTTPLIAASKAGHGAMVKLLIDNGADVNQVCKSYLCDPGTTTPLDAASKGGHEAVVQLLLEHGARTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URY4</accession>
    <name>A0A7D5URY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g014870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549037.2">
        <property type="nucleotide sequence ID" value="XM_014693551.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URY4"/>
    <dbReference type="GeneID" id="26238481"/>
    <dbReference type="KEGG" id="mbrn:26238481"/>
    <dbReference type="OrthoDB" id="3907216at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25597" checksum="7AF3F660DD39AAC8" modified="2021-02-10" version="1">MSTLRPLRGGCLCGRNRYIIALPEDGINEAQVLFSTDRSHQEPLATPLAAYIRVPLSWLHSTTFAFFDDETHTMIRRVYTHPSQDHTKRQFCGFCGTPLSYWSEEPRSEAEYINLTLGSLLQEDLQDLEDLGLIPEEGESEPEEKRAASPNRGIALRHSFGVPWFDGMVDGTRLGRMRRTHGIRRSDDGTVKVEWEIIEESDGLENDVEMETGSASGKRKLQDRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US14</accession>
    <name>A0A7D5US14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g012750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549248.1">
        <property type="nucleotide sequence ID" value="XM_014693762.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26238692"/>
    <dbReference type="KEGG" id="mbrn:26238692"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="156" mass="18135" checksum="07EAD7C98593DACF" modified="2021-02-10" version="1">MATHMREKRVAKERQKIERSGLPPGIELVDGDSLKEWTFDIRVLDTNPLYQNQTYRLRFAFPQSYPIEPPEVTFDMKPDRPVPIHPHIYSNGFICLDLLDTQGWSPVQSAESVCMSIQSMLTSNSKDERPPGDEEFVRGNRLRPRDIEFLYHDNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US55</accession>
    <name>A0A7D5US55_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nineteen complex-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g025240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548059.1">
        <property type="nucleotide sequence ID" value="XM_014692573.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26237503"/>
    <dbReference type="KEGG" id="mbrn:26237503"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50471" checksum="41A2DA9644ABBAD2" modified="2021-02-10" version="1">MSSFAAKRKARVIKVDDEEGSDGSSSSGLDAAGSKEDVHKPLFGSKSGRKPFRQSGLRKTFNPGEGDTSAATGSTGNEDAEDDGPVVVRPNRPGAGKQKKKGPKTRLSFGGGPESGESEDLATPKQVPLGQRALENSAVRRGIAVRTLPTRSTQEEEEDRPRYSKEYLDELQSSTPSTPQDISNLHISDADEMELDPSELDGALVVEYPGASSPKQGTQILSEAEIRERKERRARLAQEQGFLSVEDDDTDAFGRKKKDDGRLLADDEDLGEGFDDYVEDGGLSLGKRAEKERRKKERKQMAELITAAEGHSSDDSSDSDAERRMAYEASQSKAGLDGLKKPRKNPAGDLLQIPPKITPLPSLSECLTRLQATLREMENDLKVKNAHLDQLRKEREDIVKRETEVQALLDETGKKYQEAMAQGKIDADAASAAGPNIELVGERGLDSLGTTPRRPDQSELDAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USH8</accession>
    <name>A0A7D5USH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prenylated Rab acceptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g012690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549254.1">
        <property type="nucleotide sequence ID" value="XM_014693768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USH8"/>
    <dbReference type="GeneID" id="26238698"/>
    <dbReference type="KEGG" id="mbrn:26238698"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41550" checksum="2412CE99EFD2176C" modified="2021-02-10" version="1">MRRGTRFVSDSLQFTGVDLGDRDSGTFRRRQFGASEDDSDATSDESDSEGDSDDSEDSEDSDYLDLSGLSPEEREEVLVQSAMQRINQAQATGQTDVHLRKEELEALAQRRKRMEEEERARRKKQRHSGGGSDRKKKSEQRIAVPLTQFAPVSRKKKSSLPASMEFPPRQDSLPRQIAGGDLPADGRDRQGYPPMGYFPPPSASRSRPRSGTSSSQRPPSRARDEYEYSSSRPRSSVGSLRDTHLDPFQYQTAGPHAPYPPGAAAASSRRHASGPSEVMHDQRRSTVNPPAARSSHGSRRTSYGGDTSDAHSSNSEDSNSDGRVQPPIREPVSKTRERGRNSTIVVEESPERVRSKKKSSSPVKRKQVAGKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USX0</accession>
    <name>A0A7D5USX0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GLE1</name>
        <name evidence="12" type="ORF">G6M90_00g003920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542046.1">
        <property type="nucleotide sequence ID" value="XM_014686560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USX0"/>
    <dbReference type="GeneID" id="26245077"/>
    <dbReference type="KEGG" id="mbrn:26245077"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="89"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="539" mass="58340" checksum="D36582078BE6B063" modified="2021-02-10" version="1">MANSSPLRRSQLLSSPDRPYLSNFLLDSRNNELSHRDALAAAQAEHDRVREAAIRVYELHELKEEHNRILEQGRREQERLKAEAAIAAEEKRLQELKAKSIPKPPPPPPEPAKPVEKPAGEKKPVSVVSEPREVKGSEPLAQTQAKTQPSAPAPQQNGLFSNLGKPVPSSPFAAAGQQTKSQQPSVLDQNRTSPPEAKTSQSQQPVAPSQTPQLPKSSVDPLSDQYIRIHQALKQLRKDIVAASKVAGSPLKGKVGTIRREIRVSIGQLTGGKGANVSSTTKIMSLLRQSLDGQLPSPPVVVGQFVAIPREPSTQDIPNNGAELPSLFIYLMNICAKGIISQFINEGGANPKAADPIGVFTAQVFSHKDFSWRGQSLIDILVAKFRVVCPVLFGSRGNEKTEKGRQALGWKKDGPSWIPEQAHNNRMAGLGAGFASISLRDFSKASKTNPYPPTHYWKAFASIVNCPTAQISNTQLVVLRSMIDGHESRFINFYGNAAIAALQLALVEFPKRAPANSPAAGSLRALADILRSDSGLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT84</accession>
    <name>A0A7D5UT84_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g046490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI66434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544775.1">
        <property type="nucleotide sequence ID" value="XM_014689289.1"/>
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    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="176" mass="19864" checksum="F370601B8AA43158" modified="2021-02-10" version="1">MSSGIRDKLYLPVVGTQLVGMLILDLVPFYPKFLWQSPSSLLHPLVSLRKWWTIQSGDPYFASCTHEPWFEAFLYVELLVQLPLTAYLAYKLGSMKPTSGATELAALAYACVTFMGATACAYDIWHMGADKVSVEHKPRLFWGTYLPFAVIPALMAVDMYLRLLARVQDPRPTKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTB9</accession>
    <name>A0A7D5UTB9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">set8</name>
        <name evidence="2" type="ORF">G6M90_00g011030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549418.2">
        <property type="nucleotide sequence ID" value="XM_014693932.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTB9"/>
    <dbReference type="GeneID" id="26238862"/>
    <dbReference type="KEGG" id="mbrn:26238862"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF76">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="17"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="489" mass="54295" checksum="39976BF446C78CBC" modified="2021-02-10" version="1">MSSQLPIDTFPAWAHLNDVQFTHVNLQDVGEGKGFGLVAHEDLESAEADGTSKGLVTIPHDLVLSAEAVEDFAKVDHNFKQLLEAVGRQSTRGDIMLYLVSQFAQSSRPKGLSPTPWTEYIRLLPRPIPVPTMWTEPERLLLNGTSLEAALEAKLLSLGKEFDTLREVSEDFPFWNEFLWSGEEVSLEDWVLVDAWYRSRCLELPRSGAAMVPGLDMVNHSSKATAYYEEDDHDNVVLLIRPGCPVRSGEEVTISYGDAKPASEMLFSYGFIDPNNIVDKLTLRLDPFPDDPLARAKLRISNSGPTLTISRKETEDSQGASSIVWRSPFVYLMCLNEEDGLSFQLLQDTAGDRQLRLFWQGEDVTDQADDFETLIQGHDLCPVFKLRAITVLHEKVGEQLARISRGPSDDELEPLQAAGLLRAESIAAARILKDVESKLLGHALEALDNERTNLLANNHVVAYLGSKEDYPIGQEAQATAANDDADDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTH1</accession>
    <name>A0A7D5UTH1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol acetyltransferase FCK4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g009840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549532.1">
        <property type="nucleotide sequence ID" value="XM_014694046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTH1"/>
    <dbReference type="GeneID" id="26238976"/>
    <dbReference type="KEGG" id="mbrn:26238976"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="51207" checksum="A1D667B6F535AB62" modified="2021-02-10" version="1">MRHLEKLRPLGKLEQVSASCHHLGFFNNIGLSAHYALSGSTCPAGFDLRRVIYSAARDVIRKHGILFAIPVNEDTPDTSYFASLSSIDLDQSIHFLQRSLPLAAGTDGDDKELDAILEDQHNTNFKSDYGTLPFWRLVILQAPGAETEFTASFIYHHALGDGVSGLVFHKAFQTALEAACSSSSSQSEAESRVTADEKVSVLPPVEDLHPQPLPPHHPNPPGPGSKTRKEWTANSIRMPCRSRWASFCLSPGVSRAFFQECKGQETSVTAALSSIVASVLFTTLPEPEDALTCIIPVSLRPWLSLPGDAARDAIGTYFDATRVSFTRPHQSSSSSSPSGSSTDIWPGAREVSGALGDYLGNVSPTGEPYTAIAVLKTIPDFSVVCRSMLGKPRDAAFEVTNIGVFSSSPQTGAPLWQVGRVMLSRSALASGAAVTVSIATGGDGSMTVGFSWQDGVVEDGVLDGILRGTKKYFDRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU23</accession>
    <name>A0A7D5UU23_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543199.1">
        <property type="nucleotide sequence ID" value="XM_014687713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU23"/>
    <dbReference type="GeneID" id="26244000"/>
    <dbReference type="KEGG" id="mbrn:26244000"/>
    <dbReference type="OrthoDB" id="8115477at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028970891" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="56" mass="5859" checksum="164E0B07B70D6B24" modified="2021-02-10" version="1">MKHMTAVVALAAVAIAAPVEVEKRDGECPDTATIAYCPYPDGGIINVNIGDCEQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUJ1</accession>
    <name>A0A7D5UUJ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g041900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547531.1">
        <property type="nucleotide sequence ID" value="XM_014692045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUJ1"/>
    <dbReference type="GeneID" id="26240094"/>
    <dbReference type="KEGG" id="mbrn:26240094"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000034">
        <property type="entry name" value="Putative hydroxymethylpyrimidine/ phosphomethylpyrimidine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="303"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56048" checksum="4B9B84420D136CD4" modified="2021-02-10" version="1">MVKGRVLVIAGSDCSGGAGLEADQKVLAAHGCYAMTATTALTAQNTTGVKGIHVIPAAFVEQQIEACIEDVGVDVIKTGMLAAAETIDMIARQVAKHGITSLVVDPVMVSTSGAQLLPREAIRELSMHLLPRATVLTPNIPEAILILSENGDSALAEKKICSVSDVEFIGRRIQALGPEWVLVKGGHLPFRADMSVAETEHEKHVVVDLLVGPEGKVFRVQSPYQPSTSTHGTGCSLASAIAAGLAKGIDVPAAVHSACRYIEAGIRSAPKLGKGNGPLDHFHSIQSLPFAPGYFIEYLLQRPDVKDVWETFVYHPFVMALGDGTLPLESFKGYIVQDYLYLVHFSRANALAAYKSKDIESIRRANKIVGYIIHEMQLHVNYCKQFGISEEEIQATEEKQACTAYTRYVLDVGQSEDWLALQMALAPCLLGYGAVAQMLHSHRLTRTKDNIYWPWIQNYVAEDYTSAVRLGSELLEKHMRLQSPSRVEELIKIFIHGTKMETGFWEMFPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV74</accession>
    <name>A0A7D5UV74_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lymphoid-specific helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HELLS</name>
        <name evidence="12" type="ORF">G6M90_00g046090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544736.1">
        <property type="nucleotide sequence ID" value="XM_014689250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV74"/>
    <dbReference type="GeneID" id="26242077"/>
    <dbReference type="KEGG" id="mbrn:26242077"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001315">
        <property type="entry name" value="SNF2 family helicase/ATPase PasG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="135"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="636"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="411"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="869" mass="98143" checksum="8AEBCDB475E85A7F" modified="2021-02-10" version="1">MTSPPSSPPPVESPKSDVLNHITENSLLKEERDARDENRKAEEQRAIAARKPRRKKKAETKSEREAKARELDELLMKSAAFSDILTKKTQVLGRVGSSLDGKTLGEHNLQMAKQPKCMVGGTMRDYQLEGLTWMFEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLVVAPLSTLSNWMDEFHKWTPSIPVIMYHGNQAQRQEIFRTNMLKNLKGGRPTAKFPVVCTSYEMVLRDQHNLSRIQWEFIIIDEGHRMKNAEAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDERGTEEFIADQMKQDLVKKIHLILQPLLLRRIKQDVAAYLPRKREYVLFAPMTKEQTDLYNVFTNKEIDTRQYLEQKVTEKVNSAMASGSSTRASSRSSSHTAAVAKKNGSSNKSTISLPVRQSPRGKKAENKPISSIPNAFSLMMRKRSASQPLKGDAQKTPATPAKQATKRKSPPTSVRSETKSARSSRHSTPASTRGRSQRGKTYAEADSDEEDALSDDAFEAKLAGEVESEEEEEVDELQSPEEVERAQTLELAKKQLAQKKLGNPLAQLRLVCNSPHNFYNPWATSTHIPVDESIITCSGKMLLLDRLLQKLFDRGHKVLLFSQFKTQLDILEDYSRELRGWNVCRIDGSVPQDSRRQQIHDFNNDADYNLFLLSTRAGGQGINLASADTVILFDSDFNPQQDLQAQDRCHRIGQTRPVIVYRLATKDTVEESLLMSADAKRRLEKLVIKKGGFKTMGQKMENKEQLDAETLRALLLKDGQVYEASGGDQILSDEDLDTLCDRSDEAYERAASGLDDADGYRVVETGADSIKMARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVT3</accession>
    <name>A0A7D5UVT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">for</name>
        <name evidence="11" type="ORF">G6M90_00g043730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547707.1">
        <property type="nucleotide sequence ID" value="XM_014692221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVT3"/>
    <dbReference type="GeneID" id="26240270"/>
    <dbReference type="KEGG" id="mbrn:26240270"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="481" mass="53106" checksum="C060E31BF33E7621" modified="2021-02-10" version="1">MSSDYALSASHKEMLEKPLLETDPEVATIMKDEVQRQRESIVLIASENITSRAVFDALGSPMSNKYSEGYPGARYYGGNQHIDRIELLCQKRALEAFHLDPERWGVNVQCLSGSPANLQVYQAIMPPHGRLMGLDLPHGGHLSHGYQTPQRKISAVSTYFETMPYRVDLETGIIDYDMLAKNAILYRPKILVAGTSAYCRLIDYKRMREIADSVGAYLVVDMAHISGLIAAEVIPTPFQYADVVTTTTHKSLRGPRGAMIFFRKGVRSVDAKTGKETLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQAQTPEFKAYQEQVVSNAKTLENTFKSLGHKLVADGTDSHMVLLDLRQFSLDGARVEAVLEQINIACNKNAIPGDKSALTPCGIRIGTPAMSSRGFGEKDFERVAKYIDESIKICKEVQAALPKEANKLKDFKAKVASGEIPRINELRKEIAAWTSAFPLPVEGWRLDAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW36</accession>
    <name>A0A7D5UW36_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter asaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">asaE_7</name>
        <name evidence="4" type="ORF">G6M90_00g063090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542573.2">
        <property type="nucleotide sequence ID" value="XM_014687087.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW36"/>
    <dbReference type="GeneID" id="26244522"/>
    <dbReference type="KEGG" id="mbrn:26244522"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="457" mass="49682" checksum="C6CE70613B88715A" modified="2021-02-10" version="1">MGSTASLTDKEGRNDSLLSLSDAERDELWTEKNPFFRPADRGSHAWLFLTASFMIEGLALGFPGAYGVFQAYYSTHEPFKNAAGLPAVATCATAYQGIMYLGMPFSMGIQRQYPRLSTWSPVVGVLIMCLSLIAASFSTKVPHLVLTQGVLFAIGSSLSYCPCVAYLNEWFDKRKGMAYGIMWAGTGLSGSILPFLLEFLLGRFGFRTTLRFCAAGLVALTLPLVYFIKPRIPPQLQKRHINPFNFRFALSQTFVLHMLANSVQALGFFLPSIYLPTYARSVLGSGEFPAAATVLLLNLASTVGCPSMGWLSDHLHVANCLFIATVGASLATFLIWGFTTSIPLLLTYCGFYGLFAGSYTSAWTGLMRQITTDNTISAKYRCEDIDPVMVMAVLAAGRGIGGVLSGPLSQALVEHMLWKGEAYAGYGSGYGPLILFTGVTAAVAGIVLPWRYMGWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW61</accession>
    <name>A0A7D5UW61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g049860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545093.1">
        <property type="nucleotide sequence ID" value="XM_014689607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW61"/>
    <dbReference type="GeneID" id="26242434"/>
    <dbReference type="KEGG" id="mbrn:26242434"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="42"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="473" mass="53617" checksum="C128038B48F37BF1" modified="2021-02-10" version="1">MSTEKHVDSDVQVQEDGDERLPEVNWTADEETKAKRKLDFIIMPILTLGFFCLQLDRGNMANAITDNFMADVGIDQDQFNVGQQMLSLGIVLTEIPSNMILYRVGPGKWLTLQLFLFGIVSTFQAFQRGYGAFIATRFLLGITESGFIPGGLWTLSTWYTRDETAKRVMIFYFGNQIGQASAKLLAYGILHMRGVGGQPGWFWLFALMGAFTVLGGFVYGLFLPDSFQRPRSTFLPQVTWFTERELYILQTRVLRDDPMKGKKKRKIGLDAFKRTFIDWRVWVHFLITLCNNGPQRAFDTYAPSIVTSFGFGRLVSNALAAVGLFLQVPVSFAFSWISDRFNLRGETVVVGMFCHLLGYVFNRIFTRVQLRGVRYFGVVWTQTFGTFSHPLNIAWLSLTCKDSEQRALAMAGVIMNANIAGIYGAQIFRSDDKPLYQRGFTVAIAVLSVGLVLAVSRWADDFLHRRRKVRALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWC9</accession>
    <name>A0A7D5UWC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g049360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545045.1">
        <property type="nucleotide sequence ID" value="XM_014689559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWC9"/>
    <dbReference type="GeneID" id="26242386"/>
    <dbReference type="KEGG" id="mbrn:26242386"/>
    <dbReference type="OrthoDB" id="4940742at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="111" mass="12721" checksum="31D59B8AF2607694" modified="2021-02-10" version="1">MSSGEGEMGDVHLGLEYREKVVALWDRKGWDFDAVVRLTMGFSKVKTGHISRHEKVVWFVECASKDECRDAWHHCVLALRRRFVVVPTPWRVCVVATVGNDMASFEDLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX23</accession>
    <name>A0A7D5UX23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g049470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545056.1">
        <property type="nucleotide sequence ID" value="XM_014689570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX23"/>
    <dbReference type="GeneID" id="26242397"/>
    <dbReference type="KEGG" id="mbrn:26242397"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="72149" checksum="BC5170FFAD31EAE5" modified="2021-02-10" version="1">MSSSTPGGRRRPPQEFTLPSGKKVIAALADAVPSLRRHYSNSTDDVEVVVQGSAEHTNYLKQSRQHHESRRADLKERHGAAFDEWEDVQNQLNSVTAQLSRMSTNTSGLHGNFGKFGFDAGVRTYDDGQGEANGSGEGNERADETHHEGYRQVSTIKLAKRPVVRQWFHRNVLWRGSEQTEIMAVELFFDLLYVGIIHSNGEHMSEEPNGEELLRFAVTFIMSWKIWTDVTMALSWFETDDVLTRLEILFEIALLLAFTTNMTNCFVDDPAHNTYTQLVSFYLAARLLFSVHYVVIAYLVPMVRGAMITSAITVLVPSALWIASIHVEMPGRLGLIWPALALDMYGSGIFIGLFRYARSAGADTSMGKKLNKLFEFYPAMNIEHKVERMNAFVSLVLGYSVVGILFQSNGGYNVNAFLGKAVLGLMQAFFFNWIYFDVDASTINVHAIRHSANGAVLWQFAHLPFVMGYIVATSALSTLVLALDVPNTERDQLRPPYSVRAEEHLSSGVRFFYCQGLAIALLSMAFISLSHSHRTPSTMRLSKPVRLINRVLVCIIMFLLPMATHLDSLSLISTTLGLTAYVLIVELWGKSCKDESFFPGRRDVSKMRAMADAKSAEAEVQGTDNPNPGQMRADRMPLDQNDTAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXA3</accession>
    <name>A0A7D5UXA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TOS1</name>
        <name evidence="12" type="ORF">G6M90_00g059120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
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        <property type="protein sequence ID" value="QLI69017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544485.1">
        <property type="nucleotide sequence ID" value="XM_014688999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXA3"/>
    <dbReference type="GeneID" id="26242897"/>
    <dbReference type="KEGG" id="mbrn:26242897"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028933215" description="glucan endo-1,3-beta-D-glucosidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="11">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="10">
        <location>
            <begin position="238"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI69017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="489" mass="52190" checksum="A84A96A1E14F8ACD" modified="2021-02-10" version="1">MKYTASVLLASAGLATALIQQCSSREAVDEGGNWFCGAVDQILYEGIQGNGSFKAVTKMSDAGECLQKDQSYRGPLAPLDQDLSVHFRGPLELRQFAVYNLASNQKRNQIDLEVGAGKSGTDARVQGGEIEAGPETSKISARHRHGHRFLHRAQRDKRGDIVTATIDGKVVTWENDYLPTATPNPVPAPAPKVQAGAGAAAVKDKDADADTTATTSKKPADKKPTDKKPSGKPAPSGSDWDRVAYYNAVKQVSENIVFMGNHGGQGSGVFDTVWGLSLSYLNSTGTGGASSPEILENIRIPSNTEFSIFSKEECNGSCGFSRVPSIAYKGFGGANKVFLFEFKMPSDGTRCPAGTRPGSPGCANPDMPAVWALNAAIPRAAQYKGCSCWGTGCGELDIYEVLAPGDSKCKSTFHMANGAGSSDYFKRPTDEYIKVATVFHEETASVSIKKLSDDVDFAKGLDDETVLSWLNRPTDDKALKLSSLFQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXS1</accession>
    <name>A0A7D5UXS1_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g044820</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
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    </dbReference>
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        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="279"/>
        </location>
    </feature>
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        <location>
            <begin position="651"/>
            <end position="677"/>
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        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
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        <location>
            <begin position="420"/>
            <end position="556"/>
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        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI68312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="719" mass="80117" checksum="D842F24D718B7396" modified="2021-02-10" version="1">MADLNIPIAVRRTRRSNAGIVKVEETESAALPPKTPRRARRAVRFSDPGLSMSSGLTPMINRTCINTPRQRRRVSTPAISTRSGTPGPPNTIFLSHNHHQSSNSLHHTIDGRVERRIRRSNLRDLLNKLEQEKKRKTQQSQAEISHLKSEIKSRDRDIYELQNATIVVDNERIWDLEQQIENLKDELAKRPSTPHHQTTSYDWTLAARDPFSDEYTDMGMDEEEDQFGDATMAHFVASTPSRARSSFPTPPATSPMLPSTPCSSRPCLPTPRSHTGTQVCLPDPEKRQAQEELASLQLEVCKLTATLDSYKNLSAKLKEKLASVEPISPQSDDAPAAHVLESKIDALLQDMSDRTEAVRLLGASIADLGFPGADASDMMAALSSGFRAARLELEYLTPGEIALPLTSHGAEVLDLLLVRLRELAKKAKEDESSIDEYHELEQSLRKQLDARVSAMDQLRSEMAKAERLLHEKGLKVQDLEVANERLRGAVDGYIRDMSELEKLVQRMEEEHRDAAATSSAQREFDRHELQKRDAGIAELQERLADAVRQSARLQREMGDVQDSSTRHVVSLNRRHGAALALRDARVLELRGEIDRVNDSLRAAHETIVVLRVDKGALEARVDDERARAKAAVESVKAELQRVLQMSHDFLRSPGREGRQAGLRDEAEDELASSPSRVDGKAAAAAAASGSLVPMASGRKLRRRYDSGLGLLEEDDVEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY65</accession>
    <name>A0A7D5UY65_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g061680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY65"/>
    <dbReference type="GeneID" id="26244652"/>
    <dbReference type="KEGG" id="mbrn:26244652"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028926181" evidence="1">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="111" mass="11206" checksum="DD62C119A038AE42" modified="2021-02-10" version="1">MQLIKLVIAALPALALADTSAAPTTTYTYTNTMTMVKTITLAQVHTVTSTWDTNSTTTTFAPTGGMTSFTPPAATTAPAPATKGPDNAAGVLDATKVAFAGVAGMLVVALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYD3</accession>
    <name>A0A7D5UYD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endothiapepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EAPA_4</name>
        <name evidence="9" type="ORF">G6M90_00g064000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542484.1">
        <property type="nucleotide sequence ID" value="XM_014686998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYD3"/>
    <dbReference type="GeneID" id="26244433"/>
    <dbReference type="KEGG" id="mbrn:26244433"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028833787" evidence="7">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="93"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="408" mass="43331" checksum="7BD927B9E8CD62FC" modified="2021-02-10" version="1">MQTFGRFLVSLVAASSLAAGAPKESFPSKNGKFSITAKHNVNFERNGPLALAKAYNKLDKPVPQDIADAVTRIQQKRETGSVTNTPNKHDQAYLAPVQIGTPPQTLNLIFDTGSADFWVFSNETASNEVKGQIPYDPKKSSTSKRMSGASWSIEYADNGTSVSGDVYTDIVTVGGLSVKSQAFASAKNISAYLSRSLAASGILGLAFSKANRIKPQKQQTFFDNAKATLDAPLFTVDLKHQADGKYNFGYIDSSAHTGLIAYTSVDSTIGGWGFTSPGFAVGDGSFTNLSISGIIDTGATLLLLPDNVVKAYYSKVKGASYDESERGYTFGCSTTLPSFSFWVGNSTITIPGSYMNYQATNDSGKTCFGGLQSSSGYGVSIFGDVALKAAFVVFDAGNNRLGWAAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYE6</accession>
    <name>A0A7D5UYE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secondary metabolism regulator laeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">laeA_3</name>
        <name evidence="1" type="ORF">G6M90_00g059440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986911.1">
        <property type="nucleotide sequence ID" value="XM_066130679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYE6"/>
    <dbReference type="GeneID" id="26242927"/>
    <dbReference type="KEGG" id="mbrn:26242927"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="33438" checksum="23CFBEBB9CD725F5" modified="2021-02-10" version="1">MSHNPCDGAKKEDYFVRYGRYYASWRPGKYLFPIDDEESSRLDMVHKLFLVVQQDELYLAPLAENRPLRIMDLGTGSGIWAIHVAESVPIGMTPVQFDIEDPCWDSLMTRCDLVHIRMLFGSIHTVLWPQIYRNIYNHLLPGSGYLEHVEIEWVPRWDENDVDKEGNGMPDSPSALEEWSNLYMTGLETLGRNGRIDGAAIRQTIEDVGFTNVEEKTIRLYMSPWMPEYHKREGARWLNMCFTRGVEGMSLWPMIIGLGMREDEVRAICERAIYESLEMRLRTYFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYF1</accession>
    <name>A0A7D5UYF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CARM1</name>
        <name evidence="9" type="ORF">G6M90_00g058770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544451.1">
        <property type="nucleotide sequence ID" value="XM_014688965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYF1"/>
    <dbReference type="GeneID" id="26242863"/>
    <dbReference type="KEGG" id="mbrn:26242863"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="509" mass="59601" checksum="4326D50A26530D2C" modified="2021-02-10" version="1">MDSPIVAQLFRQLFRNRSAGCQARVQQLRRGFPAATTSSYRHQHHHQQASSYATRASRDRGMKSNESRWQQRTNLLPEDRREEFAQYPYISMSELKKRKERPRKVKMLLRDFIDDSLYNPSYGYFSKQAVIFSPGEPFDFTTLRDDLAFQSELGRRYTSFEDHLDDVEGENPTRQLWHTPTELFRPYYGEAIARYLVTNYRLTTYPYDDLLIYEMGAGRGTLMLNILDYIREVDPQVYARTRYNIIEISTNLASLQNKHLLSTAESRGHRDKVDIVNRSIFEWDQYVPSPCFFLAMEVFDNFSHDCIRYDVATEEPLQGHVLIDGDGDFYEFYVHDLDPVAARFFRVRHAATGGNYPRPYPTNPALKWLSTKMPFAANLSEAEYIPTRLMQFFDVLEKHFPAHKLLTSDFDWLPQAVKGLNAPVVQTRYHRKMVPVTTPLVHQGYFDILFPTDFRITEAMYRAVTGKLTRVMTHGDFMRRWAYVEDTETRSGENPLLTYYKNASVLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYJ7</accession>
    <name>A0A7D5UYJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g065900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540183.1">
        <property type="nucleotide sequence ID" value="XM_014684697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYJ7"/>
    <dbReference type="GeneID" id="26246992"/>
    <dbReference type="KEGG" id="mbrn:26246992"/>
    <dbReference type="OrthoDB" id="4939837at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028955271" evidence="2">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10426" checksum="57608244F9E99AFB" modified="2021-02-10" version="1">MVRFTAIALLAFAASALAAPQGANNGGDQIFDFNDKPLKGDKKTKFLDLEKQGDAKFEELTKTYTPEQQQLENDLNSIHSQMDDILGVPKQQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYW0</accession>
    <name>A0A7D5UYW0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g072390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545824.1">
        <property type="nucleotide sequence ID" value="XM_014690338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYW0"/>
    <dbReference type="GeneID" id="26241857"/>
    <dbReference type="KEGG" id="mbrn:26241857"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF681">
        <property type="entry name" value="F-BOX PROTEIN MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="394" mass="43662" checksum="E91F30D100FFE57A" modified="2021-02-10" version="1">MESVDPDHFFETDASQAQRARKAAKAGNKHGDPLEMKSKILAAVPDPKSPLSGIFVAESAGFVRQVKLTSSEPQATYRGPKAPVTCLAIGGADNKTIFAGSWDKDIWSWDIASTHLGRKYSGHSDFVKAVLCAKLKDKDILISGGADKKILVWDIETGRRLHTIQDPTTAMLAIQHLALDPVLTTREEIVLVSAGSDPHIRRWKVRLDGYEQITETFHDRPGAERLTIEEHDTSVYRLVFDVDGEDVDLWTASADGTAKCLSRSRNFVAEDDLNHGDYVRAVQPTEQWVITAGRDEHVKVWDRATGKLYCSLEGHFEEITDLVLLRNAEGSPEKICSVGIDRTIRTWPLQKTDLDDVVKEVEEAKKSSIKEAETGGESLLTAEEEAELAELMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ37</accession>
    <name>A0A7D5UZ37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PHB1</name>
        <name evidence="6" type="ORF">G6M90_00g077650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545338.1">
        <property type="nucleotide sequence ID" value="XM_014689852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ37"/>
    <dbReference type="GeneID" id="26241371"/>
    <dbReference type="KEGG" id="mbrn:26241371"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="280" mass="30816" checksum="192B99915CF63C3E" modified="2021-02-10" version="1">MAAAARALNLMYRLAVPATAGAFLVSQSIFDVKGGTRAVIFDRLSGVKEDIINEGTHFLVPWLQRSVIFDVRTKPRNIATTTGSKDLQMVSLTLRVLHRPNVKALPKIYQNLGVDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSQKIRTELTRRAAEFNIALEDVSITHMTFGREFTKAVEQKQIAQQDAERARFIVEKAEQERQANVIRAEGEAESAETISKAIAKNGDGLVQIRKIEASREIAQQLSSNPNVAYLPTGKSGNGGQYLLSVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ79</accession>
    <name>A0A7D5UZ79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g080060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539518.1">
        <property type="nucleotide sequence ID" value="XM_014684032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ79"/>
    <dbReference type="GeneID" id="26247682"/>
    <dbReference type="KEGG" id="mbrn:26247682"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45103" checksum="EE56A8E3ABC3B7B0" modified="2021-02-10" version="1">MPVTLTIVNHAAENWRSSRVGTSGKLLELVSPKEHRRTSRVIQSSFDGRLLGENHTSSSPNGFVWAAINAYSSHHHLCIRPEDVWFAIITQVGFYVNAHAENFGAIAGAMTHLMAKNVKDPELRTWVMPSFSTTSQTDIAVASVLFMGAMQKYFSYTIRMLCGIPSVTLLGEVADWEDILSRLDKLAQLGEEPGQFADMLKPILRNMVLSFTEPSSPAVIRFWNSVADKHQMSGLCRYSGWIAAFCFWNEKGEAQLSRKCRNGTWHAVIDSENIPAGFCSVPVKVDDNGHEFNCTMIAGSVGIQARSIYPYIARERRAATCSWDAKMHAIQPLSGWWICENESAEEAEAPQTEIKATRDELIAVDKACDTKLQRSAIHKGHRHTPSMARRRDLRMRLSELRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZH3</accession>
    <name>A0A7D5UZH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinetochore protein mis13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mis13</name>
        <name evidence="3" type="ORF">G6M90_00g075880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545512.1">
        <property type="nucleotide sequence ID" value="XM_014690026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZH3"/>
    <dbReference type="GeneID" id="26241545"/>
    <dbReference type="KEGG" id="mbrn:26241545"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="474" mass="53064" checksum="029523D619E6F987" modified="2021-02-10" version="1">MTTLVATQRALEHLSMSNQQERRRSKRQVAAADFERDDDFQFVRKSKRSKTEESSGSKTTGGGRITAEQVVKESTSTANKAIAPSTSTSATPGTRRSSRRRQADDASHQDEPQTDRRPTRRSIRVATAGADDSAEGSILRGTSKATSPNGEKASKPRRWEPSPTPRRPTESKIALPMSDTPIINRNKEMRKKGGKGNRRSSLGSRGRRASSLIESGQTATPHRDVNTAEFYKHIEAEGLLEPKRMKQLLMWCGERALPKKPPHGTPNSSAILGARAIQEQILKDFAQRTDFSNWFSRDEDAPKEAPILKPNPRNIELDEKLTTLEAKIKALQDEKQAWLAICQPPPDIPPIFSSSTEAPKIELPDFNLLEPEEVKIRTYLADEMIPFADMRAKTEERIRKIQASLEFEVDQLADNVHKLEQRVLVAGRQADQVLRLSAARLKEREQREKKSAGTRDMPLMEVLRSLSNILPEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZI3</accession>
    <name>A0A7D5UZI3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPC10</name>
        <name evidence="7" type="ORF">G6M90_00g068030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540560.1">
        <property type="nucleotide sequence ID" value="XM_014685074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZI3"/>
    <dbReference type="GeneID" id="26246667"/>
    <dbReference type="KEGG" id="mbrn:26246667"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="73" mass="7978" checksum="6CCC030A01BFE003" modified="2021-02-10" version="1">MPREEYQVPSAGGTAVRGNTRDDHASRSVMTYLCGDCGSSVSLGKDALVACPHCAGRVLYKERTKRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V047</accession>
    <name>A0A7D5V047_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g060340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544604.1">
        <property type="nucleotide sequence ID" value="XM_014689118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V047"/>
    <dbReference type="GeneID" id="26243016"/>
    <dbReference type="KEGG" id="mbrn:26243016"/>
    <dbReference type="OrthoDB" id="3473305at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="311" mass="36097" checksum="77F03C297577C54F" modified="2021-02-10" version="1">MATFAELPTELRLKIWSCAVEPRVVILDDLVHQKQAYPLPSVTQLNAEARAETRQGYESVGRGSWFHFSRDILVCDANISDQSPNMPLEELALRVQRLAFWDCFPDDGRIDGPCHYSEYLARCYPGGHDGKIEFDKFWFPNLRDLWIIKIGEVDRSWMVGVDKDVPCEVRLRKTARQFRYWVDENIIEIAPLDLNEPETKLILREGRCGKTDCQMLNHGRQRMVSKIVFVDGKYNANRKDNKAGKWKQIWPWSTIIEQGSTESDTSANRMRWIMVERILTFSLRWDGSEDLGEPSSDHRRVRHGQGAIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V077</accession>
    <name>A0A7D5V077_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stringent starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sspA</name>
        <name evidence="3" type="ORF">G6M90_00g079700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539941.1">
        <property type="nucleotide sequence ID" value="XM_014684455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V077"/>
    <dbReference type="GeneID" id="26247279"/>
    <dbReference type="KEGG" id="mbrn:26247279"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03194">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03043">
        <property type="entry name" value="GST_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="230" mass="25884" checksum="FA5DDDB77B02BA53" modified="2021-02-10" version="1">MAYTLYIGNKRYSSWSMRPWVLLKALDIPFDEKLQLFKPGQRQPDFLEFSPTGKVPCLYDAERKHVAVWDSLAICEYLAEKHPAAWPRDPVARAFARSAASEMHSSFAAIRDECSMNVGLRIELGEPSDGLKRDLERLTALFGEGIQRFGGPFLAGSSFTVADAFYAPIASRVKTFGIRLDGAAGEYLDRLYEHPAVQAWIQEGIAEAEREPGHEEDCVRGRRILQDLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0C6</accession>
    <name>A0A7D5V0C6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">taf6</name>
        <name evidence="9" type="ORF">G6M90_00g064400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986914.1">
        <property type="nucleotide sequence ID" value="XM_066130777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0C6"/>
    <dbReference type="GeneID" id="26247139"/>
    <dbReference type="KEGG" id="mbrn:26247139"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="50824" checksum="E86622B157944F19" modified="2021-02-10" version="1">MANEAPRPKLLWNSDNVKDVAESVGINSLNDEALKALTQDVEYRIGQVIIEALRLMRAARRTTLTVNDVSLALKVLDVEPLYGYDSTRPLRYGEASLGPGQPLFYIEDEEVDFEKLINAPLPKVPRDMNFTAHWLAIEGVQPSIPQNPTTAESRSQELLPKGPGANPALAALAGNDNVAVKPSVKHIVSKELILYFDKIQAAILDDNPDEEVVRLRQAALGSVRDDPGLHQLVPYFINFIMDRVTHHLDDTFTLRHMMELTNALIENKSLFLDPYASSLSAPALTCLMARKLGTDDGVDAMKDQYDLRQLAASLVGRIARKYSASNTLLRPKLTRTCLKYFLDPTKPPAVLYGAIYGLLEAGGPEAIRVLVLRNMKTFDAAILQPMRDRSEGSIEYEMLVQGLVQAVASLAQRGELGAPNGVNGTASDSELSELSEFIGSIVGGKIAAAGNRALVRTILDARSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0G6</accession>
    <name>A0A7D5V0G6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g090030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541661.1">
        <property type="nucleotide sequence ID" value="XM_014686175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0G6"/>
    <dbReference type="GeneID" id="26245524"/>
    <dbReference type="KEGG" id="mbrn:26245524"/>
    <dbReference type="OrthoDB" id="5419928at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="431" mass="47652" checksum="CD39006CE6506902" modified="2021-02-10" version="1">MVFCKEDNRALLQALKNLVQSDREAGEHVPPNFDSILQSLDEMSAEIDDLVVPNLSADIRTTYSPGREEFEILQAYNSLIKAGGRPICPLSETASISKHPRKHLELLGPWVKAPLVDLAIDWKGIFEKQLSNWQHFKAWQQSNRKLEALPDTDTPETLLQAASDGANRPLSSSCYSSGSKKFAAHLAMARRRLNHCGFTKCFTFDMDLGRQDEWTTWIEYLSFECYCCDAHSRSHFKPASVNDVESAISLDHVSSLVEKEHTSRHCGIDGYSRDGTSTPHHASNCDSPMNSPQEGQYDTHASRKDEYGADEGAVSKVDGIRPWLGGLIASGGGVTHDGTGTATGEPNETNHHNLILRWALLQEPQIAANSATSQGRISATGKPWPTTHSPRRKRHWDGSLCSKRPGVFQSEGLGKNNDGGDPEHKRSRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1K6</accession>
    <name>A0A7D5V1K6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">G6M90_00g075610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545538.1">
        <property type="nucleotide sequence ID" value="XM_014690052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1K6"/>
    <dbReference type="GeneID" id="26241571"/>
    <dbReference type="KEGG" id="mbrn:26241571"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000006">
        <property type="entry name" value="Malonyl CoA-acyl carrier protein transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="62"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="425" mass="47219" checksum="F2619EAD8E178AA2" modified="2021-02-10" version="1">MQRLSSSAFRPRWRRATVKTQGERLSPRVNATLAGEDDAYWHERRWMSMGSRRPRRPRTAIFFPGQGTQKVGMLTPWLEAFPSTARELIQQVDHYAGFKLSDVIQNGPSKVLTQTTNAQPAIMATSIVILKILEREFNFKVADNFDMTLGHSLGEFAALVAGGYITFQDSLYLVKRRAAAMSDATKKAIQDYGGEYGMVAIITEPEYLRGLIAAIHDFVGHSSAGSKGESSEHVPPIEQVLIANINSKNQIVLSGNLERITTLMAHVRQFLGHDPRAVRLHSDSPFHSPIMKPAVAVMQSLLEDKSRVPGREGEDIITFPGDIPCISNVTARPFRSKEQLKELLARGCLETVRWWDSIRYLDQQEKVRRWVGIGPGKVGRNLVGKEVGMRGKDSVKGGGVWAITDPSDIDEVLRGLEETAGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V269</accession>
    <name>A0A7D5V269_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g082770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543499.1">
        <property type="nucleotide sequence ID" value="XM_014688013.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243676"/>
    <dbReference type="KEGG" id="mbrn:26243676"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="386"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="662"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1291" mass="146951" checksum="394694C64911116B" modified="2021-02-10" version="1">MALARPRLDNSEYTVGWIAALPHERTAVRAMLDETHASPQYRHEKDDNIYVLGSVRCEIGQHYVVIAGLPSGQCGNTAATTAAVQMLSTFPAIKFGLMVGIGGGIWSEKNDIRLGDVVVSNPDGSFGGVKQYDSGKSTVDGFQHSGWLKPPPRILLNAITELQSKHGMERSMIPDILRDMHRKHPLMQQSRTGPGFVHQGTSNDRLFRSDYHHQRKDENCHACDKTGEIARKERPDCDPFIHYGTIASGDKIIKDPQTRDHLAQDCLCFETEAAGLMNDFPCLVIRGISDYCDSHKNDEWQKYAAATAAAYAKELLLIIDPADVNKATRARDVARKLDQVTRAQEQVTEEIRQGQERKDRDDILEWITHIDYGHQYSAILKKRLEGTGQWLLDSTEFKNWLESKGETLFCSGIPGAGKTVLSAIVIDHLCGKFGQDSSIGIAWLFCEYDRHDEQTLEHLLLSLLKQLLKQQTTLPNCVTELYELHQRRTTRPSINDIVKLLQSSTATLSRIFVIVDALDECQTTGGCQMDFISVLFTFKDVVKANIFATSRHIDRIQKRFRGCISLEVKAKAEDIRMYLRGQKRRFTQGLVNDELQARIESKVIQASESMFLLAAFHMNRLVELKTRQDIINFLESIQESGLDAAYKKTIETIENQDQNSVSLAKRILAWTVYAERSFSIEELRHVLAVRAGTKQFNPDYMPCATDLLSVCAGLVTYNNQRGFFRLVHYTTLEFFRQTRPDWLQDMQADLAETCLTYLLYDCFRVGSCRADQVFEAEFDFYKYAAASWARHAGIDRSSGASLARKEKTQLLLDEFLATDPLPPSFLYWLFRLKECIIHDIDNFPSEDSYWGISGLVFSPLNWLSNTTFATSCRRKRFTWSSDKMTFAVLHALITASLERARLVLAPCPHPEHWHNLFSSAFEDRPPLCLDDGALGCKKSCTPEAVENLKRWNKKIFEFLFQAVDEDGLTKKAGRQKSPPEQSRDMFSRDTCSQGFSRRRLLHHKFSIIEKPDVSSLPTDPHVETRDFTEWLPLFENHDAPQRCLEEIANLTVILLLKAKAGFKEWTKEEEELFRRLLLKPVHKYQEYQYIPVDFLDQDPVLLDVIHLGCDALDFLVRSGVDVNEQFRRHPSGTALVAAVVHDLESKAPCVEYLLKHGADSNQQTNGREYGSALIAACALGRMDALNLLLQQPNIGVNMEIKFDLYGTALIAACAKGNIDALHLLLQQPNVEVAMRTEFGEYGTAFMQHAQTVEWMLYIFYYNSLMWMSIWRHNSAAIEQLLLQHVQILDWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2D7</accession>
    <name>A0A7D5V2D7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g097400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546601.2">
        <property type="nucleotide sequence ID" value="XM_014691115.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2D7"/>
    <dbReference type="GeneID" id="26241024"/>
    <dbReference type="KEGG" id="mbrn:26241024"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="105" mass="11478" checksum="6B4C81EBFAF103E3" modified="2021-02-10" version="1">MSGASRILFASTTRALGARTFSTSARRMADAAPLPAKRPMGAFRGGLFGFLFGCVLSGSAVYTYLVQEFKVSNDLLSEDIYTLQASVTRLTNYVKALEQRTQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2E8</accession>
    <name>A0A7D5V2E8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g095290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546801.1">
        <property type="nucleotide sequence ID" value="XM_014691315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2E8"/>
    <dbReference type="GeneID" id="26241224"/>
    <dbReference type="KEGG" id="mbrn:26241224"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="3">
        <location>
            <begin position="94"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="314" mass="33052" checksum="35DF8F5945DFCCA8" modified="2021-02-10" version="1">MNTTTTSPTTGDPFALTTSPTNSPPLSATAKSHRPSDGAAVASGSGIGVAANRRASSSAGSGSATRARSSARSSRSSSSKSTRTEGSHSEPRSPRVVYGRGTIERLPTELGRLCASSPLIVSSPSRVALARRIQSLIPNLNSRILDSAVVNVPARVVDDAVSRIDDRDVVISVGGASAVGLAKAIGCRKGIPHVFIPTTYSGSEMMPLLLDAYPARHSNRGDIGTSSNGGYKSSGRRHREREQGSSSRRSNGARTTSFRDPRVLPSVIIYDEDLATSLPKRISAPTDEAAMARSTELRKEDETAQWSYIHLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2G7</accession>
    <name>A0A7D5V2G7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polarized growth protein rax2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rax2</name>
        <name evidence="5" type="ORF">G6M90_00g103010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546047.1">
        <property type="nucleotide sequence ID" value="XM_014690561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2G7"/>
    <dbReference type="GeneID" id="26240470"/>
    <dbReference type="KEGG" id="mbrn:26240470"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="391"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="908"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1236" mass="130398" checksum="285D308934F38996" modified="2021-02-10" version="1">MRLPFRQHRSRRPPASTIYSTFFTLAALGPIFSEAIHFNPAPPANLDFSNLGRIAIAGDFNGISLYEYEGQISKPLPTNGSEALLARLPNGALAPVVSTDASIRAMCLLHNDDGKLKGVVIGGNFTSIDGTQSTAIALFNPNTTEISPLKGLEGEVNALYCDDSRKTVYIGGNFKASNSTNAIAWTDADGWSNLPFAGFNGQVNAISKTSNGHIVFGGSFTGLGNTSTPSQPDSQIINLSGGKVTATNGATTNGFSDPQNIVCSAGTDGPGSTWLAADNLPATWEADFGFTFQPTKLRLYNTRQDGRGTKTFRFLAFPLNGIMNFTYVDPSTGKNASCTSECPLSNDPNVKFQDFRFVNRVGMDSFQVAISDWYGSGAGLSGIELFQDDMFAYAINNFNEPNCKGIQFPSTATATGPWTEAPSVQSSSDYLVAKLSGGDINDKSASVVFTPNIVESGNYSVNMYTPGCMPDGSCSARGQVNVTGVMSTGTIDAGFSTTLYQTNYYDKFDQIYFGYIEKSSDSFKPTVTLTPLAGQNLQSLTVVAQRVGFTLTKSTGGLNSLFDFDPEQKTVDVSSLEKSPINKLGSEFGRSSAVTSLVTSGDTLFIGGNFTSKNFVNAVAIGGDKDTTSPLDGGLNGQVLDMHLEGTQLYVGGNFNSTLNGDKALGHAALYDIKSNSWNVLGGGVDGPVEHVVPMRINITSDKTETVIGLSGTFSQCNAFQNNSISPAEGFAIWVPSLQNWLQNIDQPLPTYNGVLTASLENVADVGDLFAGSLTSAQLRANGAATLSTRGLGPFPFKIEATTRSASKLHRRESISNDTLRGVITGAFYSTDSSNITVLAGHFTASSANGSTVNNLMILDGKDNESITGLGSGISADSTFITVALQGSVLYAGGMVSGTIAGKQIHGLLAYDLSSKSFGSQPAPISGRNSTVAAIAVRPDTSEVYVGGSFDKAGALGCEGLCIYNSNSGQWFQPGNGLSGEVLGLMWSSKSTLVVAGDLQANSTEKRYLATYDAKQQTWSAFPGAESIPGPVQVMTAGSRDGNQVWIAGKSAKDGSVFLMKYDGSQWLTVNGTLPAITILRSLQVFSLTKSHASTQLLGENQALMMTGSIVIPNVGIASAAIFNGTHYLPYALTTNSGNVPGTIARIFTQKDDFFSTGGGSMPLGFVVLIGLAIALGLVLLMVLAGMILDRLRKKREGYMPAPTSMYDRGSGIQRIPPHELLESLGRSRPGAAPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Y8</accession>
    <name>A0A7D5V2Y8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g081150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543356.1">
        <property type="nucleotide sequence ID" value="XM_014687870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Y8"/>
    <dbReference type="GeneID" id="26243533"/>
    <dbReference type="KEGG" id="mbrn:26243533"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF8">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="337" mass="36320" checksum="8B153C857EAA61DB" modified="2021-02-10" version="1">MSKYAKNQPVGFKNAIERVAIVGAGGTIGSNITAALLQTGKHSVTALTRKDSSNKLPEGVLVAPIDYNDEATIVAALQDQQFFIITMAPNAPRDAHSKLVQAAAKAGVPYIMPNGYGGDIANTKLGEETMLGPIAKAQRDEIERLGMQWITVCCGFWYDYSLAGGESRFGFDFDKRSLTIYDDGNTKNSTSTLSQVGRAVAKVLSLKELPDDESDTSLSLSGFLNKAVYIKSFVVSQNDMFESVKSVTGTTDADWTITHEATKTRYEDGLAQVKTGNMAGFGKLLYARAFSPDDPSDVSAKAQNQLLGLPDESLDEATKVGIDLVKVLQSRAERMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3I0</accession>
    <name>A0A7D5V3I0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g084370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987519.1">
        <property type="nucleotide sequence ID" value="XM_066131248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3I0"/>
    <dbReference type="GeneID" id="26243829"/>
    <dbReference type="KEGG" id="mbrn:26243829"/>
    <dbReference type="OrthoDB" id="3177213at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="75865" checksum="D378C6A84BECFC2D" modified="2021-02-10" version="1">MLEDDFDRQHHQHQHKKLRIFSSPLVRRTSRLSQRGPAHGGSWRRIEDGHDESNSEHHRHDQDYDLPQFQRYEEPTLLEIFYDLFFAANYNVFNDTQQVTGQTKFKASVGYFCLLWLTWFQVALFDVRYVTDSLFARATRAIQLGVLVGFVVVAPKFNPKDQDLDTMRAMSLILCFSRACLAVEYASTLWHVRRYKKAHLPLYLQIGLHAAASAVYLGVTFRFTSEKQSRVYMTWYFIAGGEAILSLLLSNLSSVASLTKTHLMKRMTLLTVMIMGEGIQQLAKEVVTIVKNPTAWDPTTIGLVTAGTTTIYLVFLVYFDWLRDSFYLPRLRQQLWTSLHLPFHLALVLFMQGFTQYLLWSKITVQAERALSIADPFDDAKEMTSLKVRDSMNASVQAFFQDYPPKILSTVETVNQALNNFTTISNSFWPLLVNGTVPSDLSSAPPGYEADLATTNDAFVTLIIAMYNALFAAFGINLEEDVSHKYPTAAKEVKDGGYQVLIYSKTWQRYNLVFAYGYIAAGCTIVLMVLLTIIARTTPFKPWPIARLAIILLLGLGTGLVATLWYDKEKLDVFLGTPWVLPTITFVWAAIFILTHLNGQGIKRNRDRLRRRKAGGSLRGEADVAMTPSSQWSHGHKESTAYRGSEAQSPSQALYHSVGGGRNEYGDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3P8</accession>
    <name>A0A7D5V3P8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g084140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543630.1">
        <property type="nucleotide sequence ID" value="XM_014688144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3P8"/>
    <dbReference type="GeneID" id="26243807"/>
    <dbReference type="KEGG" id="mbrn:26243807"/>
    <dbReference type="OrthoDB" id="4939279at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029015653" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14261" checksum="C2EEC0E02709C9F4" modified="2021-02-10" version="1">MKFSYTLVAALVGAVAASPLGEPSLSKRVDTAKIKEEVQQLNVLIQSFQEAKDKKQESKGEGWQQTIDLLKERAAAIEAAPEDKVAEEIGKLDEPLARIRKSREGAIDRYTRNLFGFSDAKDRLTEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V463</accession>
    <name>A0A7D5V463_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin structure-remodeling complex subunit rsc7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsc7_1</name>
        <name evidence="4" type="ORF">G6M90_00g098880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546459.1">
        <property type="nucleotide sequence ID" value="XM_014690973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V463"/>
    <dbReference type="GeneID" id="26240882"/>
    <dbReference type="KEGG" id="mbrn:26240882"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="517" mass="57964" checksum="0D1C1DEB5A85F1AF" modified="2021-02-10" version="1">MAPRTRIRLRLTRSLNTAESTPKGFADAEDEPMVDAAVADEGSEHEEPPAQDDDDDDQEETRLASDHEEAAATKEGEEEGDEAKEPSPPPQPVIRRKRLGRPPKNKPPDWDPMITVTEDTPRRRGRGGWRGRGGRKGGPAAPKAEQVIDAEGTVAEIVNDECVLPEDPEGETKVDKLGNLEGGRDYRCRTFTVLGRGNRLYMLSTEPARCVGFRDSYLFFTKHRKLHKIIVDDDEKRDMIERDIIPHSYKGRSIGVVTARSVFREFGARIIIGGKRIIDDYNVAQLREEGAVEGQLADPDDHFVPGEYNKNQYVAWHGASAVYHTNVPSVPVPNGKPEYKKRKVNVNDQNWMLEHAREASIFNAGINAIRKFNNAGVYDIHTNMLQYPAIMQPTRVRIEQVSPDEEAASKGSVKFPPVPLRMARNFLVMDTYCEGAPRNDASVRPNSEMPAEFVASFNGLVSVSDEIKDLLPAECRKAFDEALEAEVDFQSRWGTEKEKMSRRDPIIDKAIVPYSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V477</accession>
    <name>A0A7D5V477_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g109090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543944.1">
        <property type="nucleotide sequence ID" value="XM_014688458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V477"/>
    <dbReference type="GeneID" id="26243331"/>
    <dbReference type="KEGG" id="mbrn:26243331"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="313" mass="35004" checksum="8CE2F73649236938" modified="2021-02-10" version="1">MAKGGFWTTQKSAHHLEEPQLLSLGSTGLVFKLSDAIVVKKSRLGRSDYITAEQKVFTILKRQPPSPYIIQHFHDTKDAIFLEFMSGGNLGTILNDEQAKDGSTQRVIRVEKLQTAEDCLRWTRQLATAAAWLEQLGLAHCDIWPANILLSDARDIKLADFDRACKIGDTVPSLTEPFARLLGDEGGSDCGTYGTAGYRTEQFAIGSVAYALTRGHDPYEDEWWGRDHGPICQGKLQDMEFPVLGKDKYDSIIENCWHGRYESIAQLSEYMAGLDQYSCEVIEQQASASDARSRKHECEMLVQSGVLEKLFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4F9</accession>
    <name>A0A7D5V4F9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reducing polyketide synthase BOA9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">BOA9</name>
        <name evidence="1" type="ORF">G6M90_00g093650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540734.1">
        <property type="nucleotide sequence ID" value="XM_014685248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4F9"/>
    <dbReference type="GeneID" id="26246347"/>
    <dbReference type="KEGG" id="mbrn:26246347"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="271" mass="28849" checksum="F39A818B348CDC68" modified="2021-02-10" version="1">MDATKSVLLDGSGAVLLASPNLNRPKLSGVTEKAVVIIEHTETGLGDSLQLAVTNTGAAAQRILFAHVTEATRLKEATAISLLEAELPLLAGITDSEMRRLKLLTGQAKNVLCVTAGDLLNGKTPQMGLAAGLSHALMLEKSSLRLMVYDTDKRAEADCEAQNLLQILTSSQMTGSDLEYVENDGTVHMARFVPDTKINALFQLAQDTTVIRLDPVHFRAIEPPPKGLAEDDIKMSVKAVGLNAKDLYLLTSKADTPGATCALEFSGVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4X4</accession>
    <name>A0A7D5V4X4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oca3</name>
        <name evidence="7" type="ORF">G6M90_00g095870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546744.1">
        <property type="nucleotide sequence ID" value="XM_014691258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4X4"/>
    <dbReference type="GeneID" id="26241167"/>
    <dbReference type="KEGG" id="mbrn:26241167"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001208">
        <property type="entry name" value="Tetratricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="113"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35569" checksum="D70C8F6849251ECB" modified="2021-02-10" version="1">MAESLLQPVGSLSPAEALKLAQQAPEILRKNPKAFSASPLSSLFSTRETADTWTIYENLMIACLQTGDDEAANECLERIVNRFGDSHDRVLALKGLVKEATASNNSELEKILEEYEALLQQNDASIPIRKRKVALLRSMGKLPEAVTALNSLLDVCPTDPEAWAELADMYVTQGLYSQAVYALEEVLVLSPNAWNIHARLGEVSFMAASTASEGGSQKHYAEAVKRFCRSIELCDDYLRGYYGLKLVTDKLVQNTPKSKKDSEGFQLPDQATIEKLNETATKKLGEIVRRNGAKDKLWQGYDAREIAAARELLDSSSARVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V597</accession>
    <name>A0A7D5V597_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g113050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539304.1">
        <property type="nucleotide sequence ID" value="XM_014683818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V597"/>
    <dbReference type="GeneID" id="26247905"/>
    <dbReference type="KEGG" id="mbrn:26247905"/>
    <dbReference type="OrthoDB" id="4896611at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="173" mass="19237" checksum="F6BC1B703032AEEC" modified="2021-02-10" version="1">MNNDSEQTRQDRMAPITCKVIDTTNRGQPGVYVVLECKDQQHHVIATLESVTDEDGGISLWFPTPSQGRMDEVEPQIVDSRVSPRVSLTFFPHAPLSTCPAPFLSVQTDLYLDREECHGIILYLDPNPRLEHCPFPVASPLTQVPSRQELPIPSPLILPPPVSPKQAITDTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6S7</accession>
    <name>A0A7D5V6S7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g111320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543732.2">
        <property type="nucleotide sequence ID" value="XM_014688246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6S7"/>
    <dbReference type="GeneID" id="26243119"/>
    <dbReference type="KEGG" id="mbrn:26243119"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="400" mass="44650" checksum="BCFB980D28DE8B00" modified="2021-02-10" version="1">MVQKAITPPDSSSSECHGSSPEAKNAVKAAAPSSRRGHFKSRLGCFSCKRRRVKCNELRPECSPCRRLGLICEYPAPQSSSTPRTAVRPNPSALNLEDLRFYHQFLTAGFPTLPLRGGEVWAECAAMSYSSECLAHAILGLGASHLSRNCNVNYEAQALQHRVAAIKLVNEQLDKPPQKPIDADILFATLICLLTQSSLMSDNMVDYLTMTRGGNLVATTIIPDFNASIFKKFSPEGHVMSLGEMVEEQPKDLALIEAFRASVLGMEPICQTKNETKYLEALVACIDALKTSSHSAWLHFVPLFMMPSTFDNQEFLAFVNPENYTGKLLLIHMFLLDYVLGRFCLSLKEEPKCPGRKLTILSWTRGLAKSLPEQYRRHIEWPLQYCGELESQDSRYLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLW6</accession>
    <name>A0A7D5YLW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g029820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541190.1">
        <property type="nucleotide sequence ID" value="XM_014685704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLW6"/>
    <dbReference type="GeneID" id="26245825"/>
    <dbReference type="KEGG" id="mbrn:26245825"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="45667" checksum="6FA54A9854630832" modified="2021-02-10" version="1">MPKRNDASHRVPPKALNRSSGYVDANPEEDWSTVSDPAEKKRIQNRVAQRNHRLRMKARIEELQKQLREHEAGASERNEQTGQLQNNAKSSSNRENFSTAQQDSCTPHSVDQDIFDCVRLEDQPPSEPGDAHNGLSETVFVSSRDTSSGLAPRADKQVEPFFATEETGGMGFHGSNNLWGLEVGDTTATTASETSSGNYINGALFALQNCRPEQTVSLPTPSPEEMVLDERVQSIMKQIESAGFSDFDALVMTYYCEAFRESSPLAYEQQLSRTRRLPGILAELSKTAKQWPYREQRGFYEEAMRTAESMLILESKTARSALEAHLASLASATLTSPRKLCLTAPDLHRIKNLIRKEQPHLWGLIMALIANFQGVWRHDRSNTALATIMLMQLSGRLDSSTLIQLVQAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM64</accession>
    <name>A0A7D5YM64_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g025810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985581.1">
        <property type="nucleotide sequence ID" value="XM_066129958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM64"/>
    <dbReference type="GeneID" id="26237446"/>
    <dbReference type="KEGG" id="mbrn:26237446"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028976352" evidence="1">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="264" mass="29512" checksum="8055369503D4DB2E" modified="2021-02-10" version="1">MRTFIKHVLAAACLAATASAVTPISDSDMNQMLNEGGVSLAMKAQPMFFFGQAMKQPPCIPTFATTPDGKQVPSSKLCAFPDVGCECRNPGVGIGNPSPSFPIYYSYQKCSDTSVRVAYNFDWERVIVVFTKAADGNWRPDQLFLSQHSGYGRLQWAKIQNTINREDAAEPRGGKDGRQYLDHPKVYVEWSKHAHRDTRNTGWNDPLSQLTDNAFRSNDWWYFPKRDDYIRADRSTEIGRLLGSFDWGDASSNPPSVHDGLCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMK7</accession>
    <name>A0A7D5YMK7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g019440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548597.1">
        <property type="nucleotide sequence ID" value="XM_014693111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMK7"/>
    <dbReference type="GeneID" id="26238041"/>
    <dbReference type="KEGG" id="mbrn:26238041"/>
    <dbReference type="OrthoDB" id="5426355at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="24574" checksum="6E2E39363BCDE5A7" modified="2021-02-10" version="1">MAQQPAGNGLSYTIVPFNDISKLPACANACGPLWDANGACVPPALPTADAGTYESCFCADSRVAPFSSGGGANVCPNACPGNPQGLSSIGNWFTSFCNGKAPKNTPQTTGTNTATETNAAGSSNIGGSNSGNGGDWLSNHWQWVIMLVILVVAIAGIWIGACIWRRRYLRKKDRQTSLGQKHSGSASHPSWGPTVTGTETGTPTAHNAGRDPERGAATEKAGKTQPKKKWTVTQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNA9</accession>
    <name>A0A7D5YNA9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g032160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543151.1">
        <property type="nucleotide sequence ID" value="XM_014687665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNA9"/>
    <dbReference type="GeneID" id="26243952"/>
    <dbReference type="KEGG" id="mbrn:26243952"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="588" mass="66187" checksum="1DB7C1DC22672CFB" modified="2021-02-10" version="1">MDRRKSAITPENYTRAIISLSRRYSSTSAFPGNNYADIGEWMLQERSLLSSAKPGGAATSFASKSEQSHDLVVVYNSDEKEWDVQHYNQGQHEAFSAATSGPAEGFGQIVFIRGFLSPSWVAAIGSKYKIDPEFFRRHMDFLSPSIDRHAYSIPSLASCSNNIFRLCVNTLLHRDDFGRQHLQSQRLDESTELGTYKTQQLGSTRVCCGDSLVREYSTVCSRFSVMEQWISLCFVKRDGGWAVIAWMDQGRPLEKSPPGPWTCHLESKATPLPVLQHHPKMAFRTTNNRLDPDANASAEVQQSGVILPLQYDSLIALVDLARRAPQDPLSMCIPLFAHAAFSEVQFLNLIESRIQTQMNAIVKGVLTDTLGTLQYLSNILNRHARQLQDSIAALCKLAERRSHLLNEVKVEARLPPKSAGPTNSSVGKRRQMPGIETVQKSGSNSSDSSFTAKGLLNDYEQLCARCIDLSKMCTRGMTLAMNKATIEESRKAIEQSERLKKLTLLATFFIPLSFSSSLFSMNIDLLEQRVKFWWFFVLCIPITLLAYILYLWDLPAMRQFWVRFWKVCHGVGRDRAFGSSEKDASYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNG4</accession>
    <name>A0A7D5YNG4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Armt1</name>
        <name evidence="9" type="ORF">G6M90_00g045430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986193.1">
        <property type="nucleotide sequence ID" value="XM_066130379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNG4"/>
    <dbReference type="GeneID" id="90967702"/>
    <dbReference type="KEGG" id="mbrn:90967702"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="474" mass="53862" checksum="37450DFBC33A2F5A" modified="2021-02-10" version="1">MEYDTKTPKSVTSDPTSFAHDSVRNRWPVILTGAIDDVHRTAHNADPEKQAEGNKIIQQLVDLKYGVLHDHKLTPIIVDDGYPDEIARYNEEIKQLGEPTWLDVPWLFSECYMYRRISTFFSLTKHWKNYDIFSRQKMDTFRTSRNAVVELASRYKEFVTELRSNKDATHDEEAEKLLFTEMFEICLWGNATDLSLLTNLTYEDIQKLQGSQARKAAEKNILINHLPEAYAILKKARDEGKKERRVDFVLDNSGFELYVDLVLAGFLLTSGLATHIILHPKSIPWFVSDVLPGDYGLLLNAIADPKKFFETQSDEEKAQDKTPAPLTDKEAEDLLFVAQEWTNFYAEDRIILRPNRYWTAGGSFWRLPAEAHDLHEDMKHAELTIFKGDLNYRKLTGDAHWDPTTPWTTALGPMGPGSGINVLSLRTCKADVVVGLPAGKDEELRATEGGGGDTGARRWAWHGKWAVVCLSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNP3</accession>
    <name>A0A7D5YNP3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 10">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MSH4</name>
        <name evidence="13" type="ORF">G6M90_00g005180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542165.1">
        <property type="nucleotide sequence ID" value="XM_014686679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNP3"/>
    <dbReference type="GeneID" id="26245196"/>
    <dbReference type="KEGG" id="mbrn:26245196"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="862" mass="96519" checksum="D14A64F6C62BF3E8" modified="2021-02-10" version="1">MPRQPRQSRSSRTTSSYFQRPSRALNTSSSTSSRRPPRDISEGGSSMTATPSIAGIVSSTAKSNITAGRSRPSTSVSGRKSRTGTLSTMLGASDQQTIICAVAESRGISPSIGLALVNITLGEAVLSQICDNQSYVKTIHKLQIAGPSRIVLMSTACPPNKDSVLYTLIDELIPDADIEVLDRSAWSEVDGLEYIDNLAFKSDIDPMKVAVQGKYYCISSLAAHTFTISFAPNSLRIKYRPSEDTMMVDISVIQSLEIIQNLDKPKSKDSLFGLLNQTKTPMGSRMLRNNILQPPTKYDTFIRPRYEALEELTSEEEMFHAVRKALENFKDIERMITISTKSSITHAEEQINHVILIKTFLESVPELYQALAECNSALLLKIRDICHPNTTDPILSRIHQVVEADVTYMTSPLDMRNQRTFAVKAGINDMLDVARQAYKELTNDIHLHVNDIQAQHGIQLTVKFDHGRKYWLRIKSGDLNKDTLPQVFINVVKKKDHIQCQTLSLVKLNFRLSETSNEIIMRSDKVIQELILDLRESSPQLFRVCESVALVDMIASFAHLATIKDYVRPEILDTLALKAARHPILDNIMFEGFVPNDYYATPQHRFHIVTGCNMAGKTTYIRAIALLQIMAQIGCFVPAEYASFPVMHNLFARVSLTDNLEANLSTYSLEMREMAFILRNVNGKSLVIIDELGRGTSPRDGLAMAIAMSEALIQSGAFVWFATHFVDLTRVLEDRPGVLSLHLASERSISDEGEPRLVMLYKAKSGVVDTNQHYGIDLARAIGFPEPFTKRAEEVAKALRQQREASLRDSESRRLVARRKLVLSLHEALKQAYEYGSDEALPGYLKHLQEDFISRMNDLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRA5</accession>
    <name>A0A7D5YRA5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">Rnaseh1</name>
        <name evidence="14" type="ORF">G6M90_00g034290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986160.1">
        <property type="nucleotide sequence ID" value="XM_066130147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRA5"/>
    <dbReference type="GeneID" id="26239390"/>
    <dbReference type="KEGG" id="mbrn:26239390"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000090">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="13">
        <location>
            <begin position="605"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="758" mass="82426" checksum="4B43D6C52A30AC3C" modified="2021-02-10" version="1">MADETSGNSCPVSGDISGDDSQSQPLPTPGLKPNPIVDDLKKNHLNKGVLIPLKTTQEVRQDHTTVYAYITRAPTKSANDVITALRTLRPEGGANPLPHLRTCAKPTDLPAHLKTQFMNDDPVGRQIHTSKSTWIYIIAGEAREISKSDLIKTLSTVDALENDPFIATITIPLLAPTSQVQAALWSSQYWPTVYRKNNPLGPHPSMVGRGTDEIKEDASLWMALAHQVALQAKEAGIGEAMGAVIVQRGENGTELVGLAGDARKHQECNGAILNNTVTHCVLRAISMVAQKLVRHEHREAGITAEAANLYYDCFQDQPLIELERRCFEQEHPNKDGYLCHGLELTQPCATPANCAKLASKALLLLLSSGYGSRFTQTVGRNHYFSKEARIRVYVPTRLLSTTATRSVFGFLNRIIKTALPDSEMNKRAAPGVNATASPPKKRKTDNVQKFYAVQAGFRPGVYMTYAECSAQTAGFRGAVFKSFTSRSDAEAFAEGKKVAASSDEPERFYAVAVGNPTGIYTDWNEAALAIKGVKGPKYKRFGTRMEAVVYIKQHGSREAIEALGETYAAAPVELPVSPTPVVASTKKTASKTAAKKAEPGVQRPAEDVLQIYTDGSSLANGKAGSRAGVGVYFGDGDPRNVSERLVGDPQTNQRAELMAMLRALEIAPLEQTVQIISDSQYSINCVTQWAIGWKHKGWKTATGENVKNQDIIRAVLDKMDERTKTGANTYFHWVKGHASDRGNVAADRLAVRGAKMAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRQ4</accession>
    <name>A0A7D5YRQ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH dehydrogenase afvA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">afvA</name>
        <name evidence="2" type="ORF">G6M90_00g053160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540442.1">
        <property type="nucleotide sequence ID" value="XM_014684956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRQ4"/>
    <dbReference type="GeneID" id="26246804"/>
    <dbReference type="KEGG" id="mbrn:26246804"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="453" mass="48683" checksum="3767601C608D0C06" modified="2021-02-10" version="1">MAAYLTQRISHPHHGIPVSRSETPAPEKTAKCLAPIPNVAAKGVPFFTPEQDPVAGSAVDPQPSGKPIPKLFTPLKIRGITMPNRIWMSPMCQYSAHEGFHTPWHITHYGGMIQRGPGLMMIEATSVQPNGRITPEDSGIWLDAHVDTLKKHVDFAHSQNALIGIQLAHAGRKASTVAPWLSSGATATDEVGGWPSDVVGPSDAPFAEHYPTPRAMSLAEIDQFKRDFLSAVRRAVRAGFDVIELHFAHGYLVSSFLSPAVNKRTDQYGGSFENRTRLALELVEAARAAIPKDMPLFARISATDWLDTNPNWDGGASWTVDESVKLAKLFAERGVDVLDVSSGGNHSHQKVIGGPGYQAPFAKAIKAAVGDAMLVSSVGSIKTGEVARDIIEGGKDKDDTPLDLIAAGRMFLKNPGLVWSWADELGVTIHVAHQIGWGFGGRASKKSGKSTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS01</accession>
    <name>A0A7D5YS01_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Early meiotic induction protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EMI1</name>
        <name evidence="2" type="ORF">G6M90_00g050550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545160.1">
        <property type="nucleotide sequence ID" value="XM_014689674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS01"/>
    <dbReference type="GeneID" id="26242501"/>
    <dbReference type="KEGG" id="mbrn:26242501"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="230" mass="26040" checksum="4F31D64323F5A48C" modified="2021-02-10" version="1">MGWLWSSSSKPPTEEKAAPTPPTEQSAAPNEPVDPEIQKFFDLFKHDPEQPSTNQRATPSSENESSSSSITSWLALKASAKSTDSDVPDAPVGDALSESLLPTDMSCRQAFDLAWSCNGLGGQFNSVYRYGNMRSCSEHWDDFWFCMRTKSYTGELKANMVRTHYRNKAYRRYGDGKPNSEDVWERRTERMPPGSAFNVPVDAPTVGDDEWRRMEEERRKGVRKDMGYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSP1</accession>
    <name>A0A7D5YSP1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 monooxygenase atnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atnE</name>
        <name evidence="14" type="ORF">G6M90_00g051870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539494.2">
        <property type="nucleotide sequence ID" value="XM_014684008.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSP1"/>
    <dbReference type="GeneID" id="26247719"/>
    <dbReference type="KEGG" id="mbrn:26247719"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI67962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="514" mass="57172" checksum="698CCB0FC8F94CD7" modified="2021-02-10" version="1">MMMMNMQIFFLLASVLLVVVITSITVLCIRRLYFHPLSKYPGPFLARVTDLYAAYHAWKGDIHVDMWRQHERYGPCVRYAPNRLNLNTTGALKDIYSGNTNFQKSPNYRVLRHGAANTLTMVNRQEHARRRRIVSQGLSDAALRSHEPTLLAHIKKCFALITDADFPIQAQPQSTEKEGQKGWTQSMNMSDWFNWLTFDIMGDVVFGIGYDLLASPQNRIIPRAIEESNVRMSVLLQSPILIKIGRIDRFLFPKAIAARNQFLHFVSGLVRRVLGTECSLQTRTVVSALKSASDPVTGDALSMKEILAESTTLCVAGADTTSTALAATFFYLASTPRAYRRLQKDVRRAFASPDEIRTGPALSKLTYLRACIEEALRMSPPAGSSLSREILTGDATVDGRALPAGTEAGVPIYAIHHNAKYFPDPFEYRPERWLRSESGTTGPSVDDARAAFCPFSVGTRSCVGKGMAMIELSLTVAYAMYTLDFTLTSENDSLKGWGFSGEFPLADHITGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSQ6</accession>
    <name>A0A7D5YSQ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g070950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986982.1">
        <property type="nucleotide sequence ID" value="XM_066130945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSQ6"/>
    <dbReference type="GeneID" id="90967932"/>
    <dbReference type="KEGG" id="mbrn:90967932"/>
    <dbReference type="OrthoDB" id="5325276at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="759" mass="83588" checksum="33DE2EEA4B0B8E1E" modified="2021-02-10" version="1">MGFLNFLTRRSREDGGSESSFGLQNGNPLASASVPSVALQSPVTRRPLEKLQKNPVNTRRRQKLTRSTKPYLLGALSDRPGTPNSEGWPGLVRPPSSRSKTCLIADSETASLAPSSLSITASRSYSSMRTSGYIDLLDAQGGLRPYDFRARVQAAGVRDYGEDVAERNMGENGVDVRSTAAKRFYEQKKRTSVTTLSNLSHILDADASTCAGSEAGDMSHIEGSVYSSTRSLSRLSMEPRQEVSGVVAGIPTARENNKRAAKSSNLAPKGTPELRSSHRDQFLASEASHMQHHNNRSTSRGRSLSARHWISTEQPIAGKTRNDGWESRHLSAESRTRSISPPSVPRYRPGSSMTTMREEDDLPNSNSQSVLRRHDFQNDNIEARQKSDDEQSEYNIPSSNRTHLPYNLDVGQAAPLQYPPDWQIAIQRAVEESLAKLPLSADLQALLELSQSGIPLDDILQRVPLHHSLHQGSIMSTTPTTDLSDYASSHTGRPHSRHTATTSIDSSARIDVHNKKALSTQEDKSLAGDQYQSSPYLTPVEDEGPLITETSTAPTSQPRTTPDVKKSTGNNGITQVEEYECLTSDYSDVDSFTERRRQVLDDDETKLFNDGGFGDIGNNLPGIASPRERKNCTVCIILANLQGRPVQTELCTHEGSMTRKQRLRALGYDYDSEESDTERDPGPVKGRTRTKKLTVGSNGGLRRLKLVDDRIDEDSEEERGETASAKNRPELRRKPKFPNGRIGPVLRQEGEAGNITDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSS3</accession>
    <name>A0A7D5YSS3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase assembly factor FMC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g037220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547083.2">
        <property type="nucleotide sequence ID" value="XM_014691597.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSS3"/>
    <dbReference type="GeneID" id="26239646"/>
    <dbReference type="KEGG" id="mbrn:26239646"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11870" checksum="DD0DBF2EACF5AE5C" modified="2021-02-10" version="1">MPPARLRSIYRSILRELPPRPVLASPRSHLHNRLRASFTDSSASSHAEAEQLVAYLRSQRLYVTLVERYNPGMDMDEEERVRLTARRVGMDMPELYARGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU31</accession>
    <name>A0A7D5YU31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="8">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Blmh</name>
        <name evidence="10" type="ORF">G6M90_00g059960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="8"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544564.1">
        <property type="nucleotide sequence ID" value="XM_014689078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU31"/>
    <dbReference type="GeneID" id="26242976"/>
    <dbReference type="KEGG" id="mbrn:26242976"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000021">
        <property type="entry name" value="Bleomycin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="501" mass="56112" checksum="6F0C16F37EFBDB47" modified="2021-02-10" version="1">MGGQQSKASASRAHDKVMVDRLRKMNLQENSISGEVNEKSGKLIRDAEPLPLDAVSLLPSTILEDPRNRLALSALSSANPRTVLTSQASKIANQHVFNTKIPFEGAPITNQRSSGRCWLFASTNVFRVAIMKRYNLESFELSQNYLYYYDKLEKSNWFLEQIIDTSGEDLDGRVVQRLLDDLISDGGQWDMVYNLVDKYGLVPQTLYPDSWNAQNSGVLNTVLKTKLREYALNLRNAIAAGQAPGVISAMKIIYMQEVQKIITLLLGPTPNPTQEFTWTYADKDNKVHSLTVTPKDFAKNISSSNFQITSTTISDLVSLVNDPRNDLMTLLTVDRLGNIVGGRDVTYINVDMKTLKEGCVKMIKAGIPVFFGCDVGKFSDKTSGVMDLHVFDYEVGIGTDLLGMTKEERLRAGESLMTHAMVLTAVHLDEKTAQPVRWRVQNSWGTDNVGDKGWFVMTDEWMDEFVYQAVVDRKFLSKEVRDVAEQEPTVLPLWDPMGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUR7</accession>
    <name>A0A7D5YUR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cellulose synthase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">bcsA</name>
        <name evidence="10" type="ORF">G6M90_00g000620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543005.1">
        <property type="nucleotide sequence ID" value="XM_014687519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUR7"/>
    <dbReference type="GeneID" id="26244378"/>
    <dbReference type="KEGG" id="mbrn:26244378"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="355"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="777" mass="87803" checksum="450B84E3FF70EAC1" modified="2021-02-10" version="1">MKGYAEEEEMLEIGTFQRRDQYHPYEQQEPSIEEFPPRPARGTPRGPASNAYSQPNSFYPDEFASPSPGWPPSIAGRSESQTLVDSAESRSSVRSWRTGQQTPVDSTGAPRYSVPFHNDSSPSTPMNQSHISLTGLLKQAQPPAGGKDWVDRESIDIVHKRDDSDIWRGWRRHLFRLVPLLTFANTGFYIAYLALRIACVVWAQNAFETTYSAAWIFIAVEIAVAIPSLMHNSWTMMSMKKRYRPKLRLRGYDVPTVDVFVTCCGEDDDLVMDTVRGACDVDYPYDKFRVIVLDDGKSETLEAAVTRLGMSYPNVYYMARVKVPGQPHHFKAGNLNYGLEQTHLLPGGAGQYMAALDADMIPERDWLRAILPHLLIDNKMALACPPQLFYNTPPSDPLSQSLDFFVHVIEPIKDALGVAWCTGSGYVVRREALDEIGNFPLGSLAEDVATSTLMLGKGWKTAFIHEPLQFGTVPEDFGSHLKQRTRWAIGTVDTAFKLKFCLWGEKIRQMTLAQRFSGFLYAVLSLYTILVSISLFAIPIILVMGKPLVAYASEEQLRWLIRACFASTISNRLCEFVLFIPAGYHTGQRGSRYQLWMSPYIALCLIRSFMLPKWLGGQVQAFKPTGSLSSALNERDPALKKNMLRRVWTILINYMGIFHLLFVYFTLVGVVLTSYRCFVRTDSTRSLLLCLVTHAFWPPLTFIFICSSLWTPVAYAIDPPQMPEREQLLDRDPKTMVAHPTPKSKKIAFGGQAAWFEFELTTSTLYTTLIFVVSFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUU4</accession>
    <name>A0A7D5YUU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540913.2">
        <property type="nucleotide sequence ID" value="XM_014685427.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUU4"/>
    <dbReference type="GeneID" id="26246219"/>
    <dbReference type="KEGG" id="mbrn:26246219"/>
    <dbReference type="OrthoDB" id="4941456at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="182"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="821" mass="93162" checksum="5AD381AB67A288DA" modified="2021-02-10" version="1">MELCSACNRFVQDNYRECKHHGTLRELKNCAETKTTPSCALCCLLWTGVQAQYSVSVSMSNVGSILANDYTLDLGYTRQGHLRWMYAKGTVMSDGTRPILGTLDIISEQESSFSQRTITTGQWDAWSHQTALTVKGWLTECHDKHPWCGRPRPQKAPTRLVDIGDPSIYRLIETKGGQKELYVALSYVWGIKKKKGESIHQLKLVKKTRSDLMKGIKPSQMTASHREGSMVARDLGYRYIWIDALCIMQDDIADWKNAAVEVPDIYNNAVLTITAGRSHDSRDGFLTERRPVKLPRRTEGSSRNLASTFEVSLAKNRAIGPADERAWCFQEALLSRRSLIFGMGQLIFKCRKHKAFQDGSHDKFMFDEAAFHHDWVLPFPPEAPRTENDRSPPTQSHIVHGWYRVAQKYAMRDMYDPFDCYAALAGIARRCESALAKASKDGAAPRYLCGLWETDTFAHALMWRRCLDATLARDCRVLEEPGPEQDPISRAPSWSWMALVGRITFHGAPVTTSGPPAAAFIRVPCCVPANGRGSWTRENWGIRTQLEAREIQTSLPLKIEVKGRPRRVRATTGRVCGYMMFLRYGEMLANHSTIDPAESENLREHGVVLQDLRDQDDEKGIALALFDLPPEEYRELPPVPKPVSDHELPLKPNYDSTYERYRGIFESASTMQLEIPVTPMAEPLQGTPTIPWIVEAPLNSVEVLGAILKPSHPFQIHTAHHVQRRFDRAHGSKPLYSEYIRLQGQLERNREVSFIRVPASAEKILRHWLMGFFKPVVLNYISIPWTTGRIQCLAHPRALVMSDRPVAGIYTYEIDLPTKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUY1</accession>
    <name>A0A7D5YUY1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g037580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547119.1">
        <property type="nucleotide sequence ID" value="XM_014691633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUY1"/>
    <dbReference type="GeneID" id="26239682"/>
    <dbReference type="KEGG" id="mbrn:26239682"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="79"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="593" mass="66565" checksum="DAC49116D43592DA" modified="2021-02-10" version="1">MSSDGGSNSSPSSGSPELLTLEAPFLLQIEETEDHDASQQLNFSRSAGLNILLRVLTKQPPGSPSESQAIPRLWLTARIESYLTTFHTRWPVLHAPVINEITDSVQVISTIIMIDSWLHGDVKLRDQILQIHDCLVRQLHKELNQSDLDPTHPWPANLYQLSLLNVIFAFETGRDNIIRQSRMLFSLLVTALRMNGCLHGDAVESQRLTHHPGDFKPFIFGTTERWKRIATCALKVDTYLSLLYGHPPLLRRDELELGLPSTFAMWNSYGIMVFFDRSRSEPWSRDNYKMSRLNVRNPEEVPSGILPEDIQLCLLGMWNDIRSLKKESMLNRDMAMLKKADLSQQLYLALEQLETIVAESRKPLVAGGYTATILKSYLGGEPSRGPNWRQEVTNRLDLCISNIRPLLLLLTIHLHADIHTLREIYLSPAPLQMEPTAASQTWQQNVLKIQEWALSADGRTAAIASLQTWFAYESSLLINPGQSAHALDPIVYLALSAAAMVLWAWTMNDAEVCVCHPTTPKAEVTSSSMHLQPDVQNWIRGGGGGISFLAQPVCKCTVAQRLSTWTEALAKAGRTWERAGVDANMFRCSWLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV40</accession>
    <name>A0A7D5YV40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7514 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g009020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549608.1">
        <property type="nucleotide sequence ID" value="XM_014694122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV40"/>
    <dbReference type="GeneID" id="26239052"/>
    <dbReference type="KEGG" id="mbrn:26239052"/>
    <dbReference type="OrthoDB" id="5413703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055936">
        <property type="entry name" value="DUF7514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39611">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN DZ-HRGP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24355">
        <property type="entry name" value="DUF7514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7514" evidence="2">
        <location>
            <begin position="218"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="617" mass="68561" checksum="16CC76DF74AA5CA6" modified="2021-02-10" version="1">MAAAGPAMESASCVGLGLNLAQDADISHFSLRSDAVAPETKPAAPRNRFQATVDDDDSDQDTVVASPARNKVADSVSSSSPSPSSSSRTSTQRPNGDFPDHHQPASPTPASRYGKARPSPSPSPSSSYSHASPSSSKSHASSSSTAYGTPNATLTPPSSAESSPKQRPAVHFSTRPPVVLHHRSNSYPVATEPSSPRYTTSSRGDGGPHMSVVDRQWGQLFTEHGEPTRRLASVLRGLANFMVREYEPRNSLVIPPVKMFALYRRYKLDKEQFPFQGIFDYQSRHCLRSLELLYQDLSCEYHLVQDHHSTRPYIPALTPVGLQTWLTAFIQAAPDAESYRLQSILMDIPLEADHQGPAPAERLPKQLSRHLFPAHRNDRTYRDIVCALDDWSKRMGSSSEPPSPSWGNLLFEAFRGASHMSSGPASMVRREKPYQTDDYKRHSSRKSPPEDVTISPANTSRRRQKSTSTASRTPQEAKYYYSSSSSSTSSSQREKAYNPEPRYFPSSRSEPSRRRYSEPSPERIKYDRHTSRRRGKSPKAARAASIDSERRYRHPPRSYSSSSYSRGAEDVDRGRMAPDSSSRTPDALPGRVDSYRFFQGRQQGPTYDDFLRGKARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVU9</accession>
    <name>A0A7D5YVU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GPN3</name>
        <name evidence="8" type="ORF">G6M90_00g102370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546109.1">
        <property type="nucleotide sequence ID" value="XM_014690623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVU9"/>
    <dbReference type="GeneID" id="26240532"/>
    <dbReference type="KEGG" id="mbrn:26240532"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="301" mass="33702" checksum="28EE6DF814F027CD" modified="2021-02-10" version="1">MSKFGAMIMGPAGAGKSTFCAALITHLQLNRRSAFYVNLDPAAETFEHTPDLDIKELISLKDAMEEVGLGPNGGLIYCFEFLMENLDWLTEALDNLTEEYLIIIDMPGQIELYTHIPILPTLMKYLSQPGSLDIRMAAVYLLEATFVVDRAKFFAGTLSAMSAMLMLEVPHINVLSKMDLVKDQVKKKDLKRFLTPDMGLLEDDPVERARRVAEGPEGDDDESRRPDESEQIMKGASFRRLNRAVAGLIESFSMINYLKLDVTNEDSVGAILSYIDDCIQFHEAQDPHEPNDDEDEAGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVW9</accession>
    <name>A0A7D5YVW9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985611.1">
        <property type="nucleotide sequence ID" value="XM_066129978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVW9"/>
    <dbReference type="GeneID" id="26237337"/>
    <dbReference type="KEGG" id="mbrn:26237337"/>
    <dbReference type="OrthoDB" id="4933424at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="44539" checksum="B799A9DB32F2B6E3" modified="2021-02-10" version="1">MTSSITLKGVYVGNKPVIVKRYLYRQYKQITDGTQCWRDNYLLERWADSQQPVVYYGQHVNGYRLLKRLGDWCWLARNTNNNELLTVKFMGRSESQQVKRELAINRFLRSRCPQSPHLCIIKDSFVIKHHLAKLHPSYRKVSFDAIAYPPMGTDLQVIDTSSARSTSLLPLSVERRVQCIKDIVRGVAELHSLGIVHADIHPGNVALPPPPVADMEALLEEPHVEHWLEREDGAPTPGCLPKSVIKPVDLGFGDGTCRVLDFGYSFRHREGAVYKADSFSYGAEKAIEFETSETTDQPFKVDSWYMGQLIYFILTNGCDFLDRRPSNLMSHWVDRMAVLENGVDEIFNEELPSRRHQRHFQPIIQQLMHGDPNRRLSVQDAVARIESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW53</accession>
    <name>A0A7D5YW53_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SID1</name>
        <name evidence="12" type="ORF">G6M90_00g035220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546916.1">
        <property type="nucleotide sequence ID" value="XM_014691430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW53"/>
    <dbReference type="GeneID" id="26239479"/>
    <dbReference type="KEGG" id="mbrn:26239479"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="599" mass="64610" checksum="2C82E788A428CD28" modified="2021-02-10" version="1">MSPHSEEVVLTSNGAADVALHGNALTPTSNGSNRAAEAPAPTLAPDAPTTSDAPQPLTSASTATLPTNKPNAEGTGASSNRASTNGNGVATHHAKANSNGQAVQEPLGSNGREFLNGAAQSSPYLVPTALDSEFDLICVGFGPASLSVAIAMHDAIAAGRKLLPDGSYPKVLFIEKQNQFAWHSGMLLPGAKMQISFIKDLATLRDPRSEFTFLNYLHRQDRLVDFTNLSTFLPARVEYEDYLRWCSSFFTRLARFGQQVVSVSPNDNSKGPVRSFTVQSRDTATGQAHTYRGRHVLVAAGGQPSMPKNFPLKHPRVVHSSQYANVIGELIPKTATSCRVVVVGAGQSAAEIFNNVASRFPNSKTYLVMRPEFLRPSDDSPFVNTVFNPEFVGSLYTKSAKYRNNFLAEARATNYGVVRLELIEALYERMYDQRRELGADEKAWPHRIMGGKQIISIEPHGETLELKVQSVQDGALDGFIDDADVEVIEADLVIAATGYQRNAHVGMLKDAWNMLPKAAPGGLQFSKGISGWNVETEQGERKIAVGRDYKVKFAPGTVADEAGVWLQGCCEGTHGLSDTLLSVLATRSGEIVDSIFGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWF9</accession>
    <name>A0A7D5YWF9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trichothecene biosynthesis protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRI14_3</name>
        <name evidence="2" type="ORF">G6M90_00g108560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543990.1">
        <property type="nucleotide sequence ID" value="XM_014688504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWF9"/>
    <dbReference type="GeneID" id="26243377"/>
    <dbReference type="KEGG" id="mbrn:26243377"/>
    <dbReference type="OrthoDB" id="4434395at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd12811">
        <property type="entry name" value="MALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054550">
        <property type="entry name" value="Mala_s_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22701">
        <property type="entry name" value="Mala_s_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028821579" evidence="1">
        <location>
            <begin position="20"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="350" mass="37953" checksum="1B7838B53CA4BCAB" modified="2021-02-10" version="1">MHRAAVLPLLASLGTIAAAAPAVTDADIIVNSFQLYPENADYDFKRKLLHFGALYNSSIAAYSPSKNTIEKITEFPPLTNDTSYHASGVKVDPFNDRLSVIVNPGAAWTTAGENITGDTWLIKLDLKTGDELWRSNLTTALDGKYGGYQDVAHDAAGNSYVIGTFPGSILKVDPIGKKITPWYVSEETNTTVTGFTGIVYLGTKFLTTYGQNGQLQRWDSCQGQGKPTPVPIGTTGTPPTTDAVLQNIEAITLPKKYEGKVLLVASNSKGVYVLRSKDGSWDSAENLGAIPNNYESDGVVVTTVQVEDRLYAVLEYFDDIKNPVPETVAGNRTEFPLQDITSAVEEYLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY50</accession>
    <name>A0A7D5YY50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pr1</name>
        <name evidence="4" type="ORF">G6M90_00g016970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986010.1">
        <property type="nucleotide sequence ID" value="XM_066129792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY50"/>
    <dbReference type="GeneID" id="26238278"/>
    <dbReference type="KEGG" id="mbrn:26238278"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028852575" evidence="2">
        <location>
            <begin position="18"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="58"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="37152" checksum="77B111E626E6F8C3" modified="2021-02-10" version="1">MSLKTLLLLAAAHLAQADSSHALFYKVVDRETAQRIASIKGLAAAGNDTPVFNDQGFWFSHFTVGASPDLEILIDTGSSDAILNPGVYKPSPGSVNANRRFRISYATTNPDGSGTLTASGNVYQDVITQLSANLTVANQTLGDIQDPASPPTFPRDGLIGYASQQGSALRGSPFINSLCDQGALSTCRFGLALRPNKTGELYYGTLATDTFTEPLTTVPLTQGEWAVQGDVTVDGAAVQHGASIITDSGTTVIFGPTHRVADVFARAGVQAVPTSTGLAGYYNCSAPPTIGLSFAGANFDILPEALAFASDGDNCTAAVHGSDAFGDNWLVGQAFFQGRYVDHNVADGTMGFADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ67</accession>
    <name>A0A7D5YZ67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LYS3</name>
        <name evidence="13" type="ORF">G6M90_00g030770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539660.2">
        <property type="nucleotide sequence ID" value="XM_014684174.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ67"/>
    <dbReference type="GeneID" id="26247571"/>
    <dbReference type="KEGG" id="mbrn:26247571"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="124"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="446" mass="48880" checksum="7A95EDD8ACAD24A4" modified="2021-02-10" version="1">MPQQSVLMLGAGFVTKPTLDLLTKAGIPVTVACRTLKTAKELAGNNKLATPTTVDVLNDNALDAEVAKHDLVISLIPYIYHVNVIKSAIRNKKNVVTTSYVSPAMMELDQQCKDAGITVMNEIGLDPGIDHLYAVKTIDEVHAAGGKIIKFLSYCGGLPAPESSDNALGYKFSWSSRGVLLALRNAASIVQDGKIFNIASKDLMGTAKPYFIMPGFAFVAYPNRDSTPYAQRYNIPEAQTIIRGTLRYAGFPQFIRCLVQVGFLEETPIKALESPITWREATQAVLGTASSDPKELEAAIVAKAEFDSPEDRDRILSGLRWIGIFSNEKITPRGNPLDTLCAVLEQKMQFEEGERDMVMLQHKFEIEHKDGSKETRTSTLVEYGDSTYSAMARLVGIPCAVAVQQVLNGTLSEKGVLAPMTAKINNPIMKELKEKYGIEMKEKTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZF3</accession>
    <name>A0A7D5YZF3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase ltmK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ltmK</name>
        <name evidence="8" type="ORF">G6M90_00g105000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541489.2">
        <property type="nucleotide sequence ID" value="XM_014686003.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZF3"/>
    <dbReference type="GeneID" id="26245739"/>
    <dbReference type="KEGG" id="mbrn:26245739"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF4">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="531" mass="60469" checksum="43C01BDDFC781DE3" modified="2021-02-10" version="1">MHDSNSTQSLSRNALSTFFHSSVYNVPAIQVILAILVLVICASLYWKPSTGIDVPYVGYRSSWEPRFLAQIRYTFSASSMISEGYKKWKDSLFQISRYDGDLLILSRNYLDDLHNRPPQELSAIHGLIENFGGRYSGLGLLGKHDVGIRAFQMKITPNLAKLCDEMVDELEYSLRTDLPPCQDWTSVSIQPFILRVVERIVHRTFVGLPLCRDPGWLKAAFGHADNVTITQIAMRSVPCFMRPLLDLCLPFSWKYKAHLRAGKKVLIPEVERRRDLETTGVDYVKPNDLLQSMVEMTNPDDEEGQPDTLAQLMMTMTAIAGHSTAASGSHVIFDLVSRPEYIDLLREEAQTTLQKSEMRFTKQSLSGLRKMDSFMRESQRHNPLSLLGFLRVVKAPAGITLQDGTHVPYGTQLCIPPHSISSDPTVLEDAESFNGLRYYEQRRRDPGQENKHQYATTDKIHLHFGYGKWACPGRFMASDMMKMIVATLLLRYDIKYPDGKGRPTNGHIHEFPFMNIYTKLLMKRRDDLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZT3</accession>
    <name>A0A7D5YZT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g096120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987771.1">
        <property type="nucleotide sequence ID" value="XM_066131504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZT3"/>
    <dbReference type="GeneID" id="90968155"/>
    <dbReference type="KEGG" id="mbrn:90968155"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="67" mass="7611" checksum="541AE97192A72E83" modified="2021-02-10" version="1">MAQTLEQRRRNAKFAKEQEARMGKSDDQIKKRAKETPKSPISPVWIGVLGFIVFGGLLFEALSRMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z038</accession>
    <name>A0A7D5Z038_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase ABA1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Abscisic acid biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytochrome P450 monooxygenase aba1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lolP1_0</name>
        <name evidence="13" type="ORF">G6M90_00g004260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Hormone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542078.2">
        <property type="nucleotide sequence ID" value="XM_014686592.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z038"/>
    <dbReference type="GeneID" id="26245109"/>
    <dbReference type="KEGG" id="mbrn:26245109"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000076">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="504" mass="56496" checksum="63D160771C4EBA4A" modified="2021-02-10" version="1">MQLTSLALGLIGLYILRLTWQFFKLRRFAGPPWTGLSNVPHSRAMLRGDCHRWYADVNRKYGPIARVAPNVLITSSPEVWTHVNNTPGYRRSPWYYNACRIEYRRDNVFSETDNEKHDRRRKQMAPGYSGRENLDLEASIDECLTQLMHLIRSKYVSSTGNAPHMDLATKAQFFTIDVISKVGLGTAFGMLQADHDIDDYIKSSAEGLTIGNTALAMGFSWLAHSPFIGKFIAPSPKDNSGFGKMMATCFRYVDQRAANPTDKRSDMLASFIRHGLSGDELRTEALEQIIAGSDTTATAIRATLLHIMTNPRVYAKLQREIDDAVRDGRAPAPGDGLISATQAKQLPYLQAVMREALRVHPPVTNIFSRDVPAAGDMVTISSCDGTKIFLPGGVSIGYSAYAMHHDKEIYGDDAEAFRPERWFEADEAKLHVMTATNELIFGHGKFQCLGKRVAQVELGKLVFETFRNFDMAVVDPTRPWRLQNCLGLLHITDMWVQVSERTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z048</accession>
    <name>A0A7D5Z048_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g052160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986342.1">
        <property type="nucleotide sequence ID" value="XM_066130526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z048"/>
    <dbReference type="GeneID" id="90967768"/>
    <dbReference type="KEGG" id="mbrn:90967768"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12248" checksum="491087003045D052" modified="2021-02-10" version="1">MQAPAAFDIANHFSKWAGFECDFSALPTRSDRREFIKEYLRTFAVLAKDSQIDQDDSLSRLMVDVDLYRGVPGFFRAIWAFIKASGSNINFDYTSYANMRISEYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0H7</accession>
    <name>A0A7D5Z0H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">FAS1_0</name>
        <name evidence="33" type="ORF">G6M90_00g007140</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33 34">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549796.1">
        <property type="nucleotide sequence ID" value="XM_014694310.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239240"/>
    <dbReference type="KEGG" id="mbrn:26239240"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000007">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="30" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="32">
        <location>
            <begin position="1695"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="2081"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="1948"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="QLI63509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2102" mass="233218" checksum="C7FD32E5172FD872" modified="2021-02-10" version="1">MYGTGTGPQTGISTPRSSASLRPLTLIHGSLETSFLVPTSLHFHASQIKDRFVASLPTATDELAQDDEPSSVAELVARYLGFVAKEVEDGEDDAQGSYEEVLKLVLNEFERAFLRGNEVHAIAAALPGIEMKKLEVIRSYYMARAVSNRTIKPHESALFRAAGDGSADIYTIFGGQGNIEEYFDELRQVFQTYSSFIGELVTSAAEQLRTLSTNPSAEKMFPKGLDIMNWLQHPDSTPDVEYLISAPVSFPLIGLVQMAHYEVTCKTLGVHPGMLRERISGSTGHSQGIVMAAATSAADDWESWREIVSSTLSILFWVGTRSQQAFPTTSMTPTMLRESIEHGEGNPTPMLSIRDLSQQEVQKHIDATNQYLPPHRHINISLINSPRNLVVTGPPTSLYGLNSRLRKVKAPTGLDQTRVPYTDRKVRFVNRFLPITAPFHSKYLAEATEMIDADLKNISIDAEDLGIPVFDTNTGKDLRTEVKGNIVPALVRLITRDPVNWEKATIFPDATHILDFGPGGVSGLGTLTSRNKEGTGVRVILAGTIEGTMNEVGYKPEIFDRDEENALRYAIDWVKEFGPRLVKTSGGRKYLDTKMSRLLGLAPIVVAGMTPCTVPWDFVAATMNAGYHIELAGGGYFMPGMMTDALLKIEKAIPSGRGITVNLIYVNPRAMAWQIPLLGKLRAEGVPIEGLTIGAGVPSIEVAQEYIETLGLKHIGFKPGSVEAIQAVVNIAKANPNFPVLLQWTGGRGGGHHSFEDFHQPILQMYGRIRRQENIILVAGSGFGGAEDTYPYITGDWAKKYGYPPMPFDGCLFGSRMMVAKEAHTSKDAKQAIIDAPGLDDSEWEKTYKGPAGGVITVRSEMGEPIHKLATRGVRFWAEMDQKIFSLPKEKRVAELKKNRDYIIKRLNDDFQKVWFGCNKQGKACDLEDMTYGEVVRRMVELLYVKDQKRWIDPTYVKLTGDFIHRVEERFTSTAGKASLLQNYADLNEPFSTVERILSHYPEAETQIINAQDVQHFLMLCLQPTQKPVTFIPSLDDNFEFFFKKDSLWQSEDLDAVIGQDVGRTCVLQGPAAVKYSTVVDEPIKDILDGIHESHIKMLTRDMYNNDEGSIPFVEYFGGKLVESEIPLDVEGLTVAYDTHKNTYRLSFAASASLPSLESWLALLAGPNRNWRHALLMSDVVVQGQKFQTNPLKRIFAPTRGLFVEIQYPNDPSKTTIIVREQPRHNQYVDVIEVKLVGKNEILVNLIKDTTALGRPVAMPLKFTYNPEAGYAPIREVMTDRNDRIKEFYWKAWFGEEPLNLDALITSTFDGGRTTITSEAINDFVHAVGNTGEAFVDRPGKIVNAPMDFAIVVGWKAITKPIFPRTIDGDLLKLVHLSNQFRMIPGAEPLKKGDEVATTAQVNAVINQEAGKMVEVCGTISRDGKPVMEVTSQFLYRGKYSDYENTFQRKIETPVQVHLATTKDVAVLRSKQWFNSDELPSDIDLLGQTLTFKLQSLVRYKNKNVFSSAETRGQVLLELPTKEVIQVASVDYEAGESHGNPVMDYLERHGSPLDQPILFENSIPLSGKTPLQLRAPSSNETYARVSGDYNPIHVSRVFSTYANLPGTITHGMYSSAAVRSLVETWAAENDIGRVRSFQATFAGMVLPNDDIQVKLQHVGMVAGRKIIKVEVSNTESEEKVLLGEAEVEQPVTAYVFTGQGSQEQGMGMELYGSSPVAKEVWDRADKYLLDNYGFSITNIVKNNPKELTIHFGGPRGKAIRQNYMAMTFETVAADGSIKSERIFKEIDESTTSYTYRSPTGLLSATQFTQPALTLMEKASFEDMKSKGLVPRDSTFAGHSLGEYSALAALADVMPIESLVSVVFYRGLTMQVAVERDAAGRSNYSMCAVNPSRISKTFNEEALQFVVNNIAEETGWLLEIVNYNIANMQYVCAGDLRALDTLAGVTNFLKMQQIDIEQMRSNIEEAKDALRKIIRGCAEATLKKPLPLELERGFATIPLRGIDVPFHSTFLRSGVKPFRSFLLKKINKTTIDPSKLVGKYIPNVTAKPFELTKEYFEDVYKLTNSPKIGAVLANWDKYTQEDESKAVSDSSSSVGYDGPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2K3</accession>
    <name>A0A7D5Z2K3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ADE2</name>
        <name evidence="14" type="ORF">G6M90_00g036350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547027.1">
        <property type="nucleotide sequence ID" value="XM_014691541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2K3"/>
    <dbReference type="GeneID" id="26239590"/>
    <dbReference type="KEGG" id="mbrn:26239590"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="124"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI67086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="611" mass="66588" checksum="CEE88C52C48A1E21" modified="2021-02-10" version="1">MSPKTPVVGLLGGGQLGRMLCESGAPLDAQIAVLDAENCPAKQINNNRHHVTGSFKDPVKIKELAANCDILTVEIEHIETEVLEEIDTNGVQVRNADGTTTNKKVAIHPSWRTLRLVQNKYEQKEYLKNQGIPIAEQMAIESGDAMLASMGEASEKFGFPWMLKARKDSYDGRGNFKISNQKDLEQAVKEFGNLSCYAEKWVPFELELAVMVIRTEDDSGKMKRVVPYPVVETVHEDNICSKVFMPPRNVSENVCKKAQKVATSVVEKLWGRGVFAVEMFLTKEGDIIFNECAPRPHNSGHASIESVPYMSQFKAQLTAILDEPLPEVLEPHVSSSIMINILGGADPDSHLPLVEKAKSMYGSRTAVYVHLYGKESKPSRKIGHITVTGFGSIKDLEAFAQPLLKMVDAIRQERLQASSKALRVQAAPTPGNPKVAKGNPLVLVTMGSDSDLPVLKAGIDILNQFGVPWEVDITSAHRTPAKMAQVAIDAADRGIKVIIAAAGGAAHLPGMLAAYTPLPVIGVPVKATHLDGLDSLLSIVQMPRGVPTATVAINNSTNAALLAIRFLGAFIPDLLEKMKKYQLEMEHQVKDKATTLRDIDVDAYLAKMGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Y2</accession>
    <name>A0A7D5Z2Y2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">msp-5</name>
        <name evidence="14" type="ORF">G6M90_00g015180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549007.1">
        <property type="nucleotide sequence ID" value="XM_014693521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Y2"/>
    <dbReference type="GeneID" id="26238451"/>
    <dbReference type="KEGG" id="mbrn:26238451"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="464"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="856"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1212" mass="133220" checksum="C97237B0729807A2" modified="2021-02-10" version="1">MATTSNMFLYSLTVQPPNNVVQAVLGQFAGTKEQLIITGAGSQLTLLRPDPSLGKVTTVLSHNVFGIIRSLASFRLAGSNKDYLIIASDSGRITVVEYLPAQNRFSRLHLETYGKSGVRRVIPGEYLACDPKGRACLIASTEKNKLVYVLNRSSQAELTISSPLEAHKPGVLVISMVALDVGYANPVFAALEMDYSEVDQDSSGQALEEVETQLVYYELDLGLNHVVRKWSEPVDPTASLLFQVPGGNDGPSGVLVCGEESITYRHSNQDAFRVPIPRRKGATEDPSRKRTIVSGVMHKLKGSAGAFFFLLQTEDGDLFKVTIDMVEDEEGSATGEVKRLKIKYFDTVPVATSLCILKSGFLYIASQFGNFSFYQFEKLGDDDTELEFSSDDFPVDPQASYDPVYFHPRPAENLALVESIPSMNPLLDCQVANLTGEDAPQIYTVCGNGARSTFRMLRHGLEVNEIVASELPGIPSAVWTLKLNRGERYDAYIVLSFTNGTLVLSIGETVEEVSDSGFSTSVPTLAAQLLGDDGLIQVHPKGIRHIRNGKVNEWDAPQHRSIVAASTNAHQVAIALSSGEIVYFEMDSDGSLAEYDEKKEMFGTVTCLSLGEVPEGRVRSSFLAVGCDDCTVRVLSLDPESTLESKSVQALTAAPSSLAIIAMDDSSSGGSTLYLHIGLHSGVYLRTVLDEVTGELTDTRQKFLGPKQVRLFQVTVQGTTCVLGLSSRPWLGYSDPITKGFVVTPLNYVDLEWGWNFSSEQCEEGIVGIQGQSLRIFSIDRLGDTLTQKAVSLTYTPKKLIKHPEQPLFYTIESDNNTLPPDLRAQLMADPAVVNGDATVLPPEDFGYPKGNRRWASCINVIDPVSEEPQVVQTVDLENNEAAVSAAIVPFASQDNESFLIVGTGKDVVVNPRSFSEAYIYVYRFQEEGRELEFIHKTKIEEPALALIPFQGKLLAGVGKTLRVYDLGMRQMLRKAQAEVAPQQIVSLNTQGSRIIVGDIQQGVTYVTYKPTTNKLIPFADDTIARWTTCTTMVDYESVAGGDKFGNMFIVRCPPKASEEADEEQSGLHLMNARDYLHGTSQRLDLMCHFYTQDIPTSMAKTSLVVGGQDVLLWSGLMGTIGVFIPLISREDADFFQSLESHLRTEDPPLAGRDHLMYRSYYAPVKGIIDGDLCERYTLLPNDKKQMIAGELDRSVREIERKISDIRTRSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z306</accession>
    <name>A0A7D5Z306_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threo-3-deoxy-hexylosonate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lga1</name>
        <name evidence="4" type="ORF">G6M90_00g062680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542613.1">
        <property type="nucleotide sequence ID" value="XM_014687127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z306"/>
    <dbReference type="GeneID" id="26244562"/>
    <dbReference type="KEGG" id="mbrn:26244562"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="316" mass="33969" checksum="F912A163E983C290" modified="2021-02-10" version="1">MPARRSLPVGIYAPTMTFFDPETEDVDIPTIKKHAQRLIRDGLVGLVTMGSNGEAVHCTREEKLAVTKATREALDEAGFTSTPIILGATEGSVRGTVELSKLAAEAGADYTLLLPPSYYRAQIDEESIVDFFTAVADASPLPVIIYNYPGAVSGIDLDSDVLIKLGQHPNIVGTKFTCGNTGKLTRVALGTNARTPFQEGSGYMAFGGMCDFTLQTLASGGSGIIAGGANVMPKVCARVWNLYAEGKKDEAQALQKILSRGDWPLTKAAIAGTKQAIQMHFGYGGYPRRPLKRLDEARLKAIEEGIREVMEIEKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3F6</accession>
    <name>A0A7D5Z3F6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g025550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692542.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26237472"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="348"/>
        </location>
    </feature>
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            <begin position="361"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <begin position="531"/>
            <end position="578"/>
        </location>
    </feature>
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            <end position="841"/>
        </location>
    </feature>
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            <begin position="1326"/>
            <end position="1530"/>
        </location>
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            <begin position="1596"/>
            <end position="1655"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
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        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
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            <begin position="390"/>
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            <begin position="410"/>
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            <begin position="463"/>
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            <begin position="1622"/>
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        </location>
    </feature>
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        <location>
            <begin position="1634"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1655" mass="184853" checksum="715F7B2D15131A3F" modified="2021-02-10" version="1">MAAQQQRWGHFPDSQGSQGLRDEYDDYTYPTHEHRRSLDAQPPRRSKSNRASVQTANTDALTESTFSPHSPTASSFAGAAQGLAPRPPSYQRPVFVANAAPDVGAGMGAGMGNVGANVNVGVAVSNIPQEHVSHMPEETSRGPHRRSSEQFQDSLSESTRQALQALPNTPKVPRGPPVSYHQPYETSEPPYTRLNSNSNNVSPTSFQSLSLPPGRFAVDDGMEPEGYYTTRREDYPDFPRSQIHDVTCGKGVVAPPMMPQDIAAGGTRRPSVTLPSERRKKFANDRSPLQRLELTLDSMTKEEKRARVQAAEQRARERAAKRAAEASTAQSGESQGRRIPIEPPRYHPEAIVPTVPVDEPQMNLAETGNRGHPYLQHQPVQHQHPIPSRYRAEAADHGHVAGPPPPLHVPEQREEHGESRSGLPRRNLSFRERAARNEKEHILKQASPVDQPTAFFSGGPSGGTNIARNGSNKLRKEPPTDQWTSTKPNMERKVPGAAIPEPLSATRAHGAAGRLPRAIRDKELPPVPTAQELAQGIQRRATEPIYRKELRPDEEYIPPATSSNANTSSIQSPGTEQRDLAVVGRRPERQESIHSVEDLPQHRVSNMIFKDPENLRPGEGLYQPPVWLNEFQNATVGFLGGTLLDLTENHQAISDKNKAWWETTGGRKNSTYSSRPRKAEAFDGEYDDTNAPTRFKPSLYLKCGPLLRYCGIRQEKVPTRSQNSALSNREIWRGSVMIVTHDLESSYDIAPMLRLFVQDIQLLPPPPLQVNGDLPPEYVDPIAGHPKLGRRGETIYVRPVEHLEEARDLSRTETDEGLYEKSRSPPDIPPPNGTTELPQSFAGRQKRILTDGEKLQKYKDVRGFRLHAERGYTFWRFNIEVELREKQQRIAYRINRGPSMAFWVPPRGQAMNIMFHSCNGFSASANPDDLSGPDPMWRDVLNTHQSQPFHVMIGGGDQIYNDSVAHECSLFDEWLGIRHPQHKHAAAFTASMQDEMEEFYLQRYCMWFSQGLFSLAASQIPMVNMYDDHDIFDGYGSYPHHYMKSPVFAGLGAVAFKYYMLFQHQSVLTETENTEPSWILGQEPGPYIKELSRSVYVSMGGKVALLAVDCRTERTEHDVMNNQTWETIINRMYAEVRRGHVEHLLVLLGVPIAYPRLVWLENILTSRLMDPVKALGRTGMFGKALNNIDGGVEVLDDLNDHWTAKNHKHERSIIMEDLQDLAIDKSLRITILSGDVHLAAIGQFYSNPKLGLPKHKDPRYMINVVSSAIANTPPSDILADVLNKRNKVHHFDKQTDESMVPLFHHGVDGKPRNNKHLLPHRNWCSIRSWSPGRTPPPTPPLSTYDRSPSPPSVVNSNGGGAGGLFRRLSLGGGTRPTSNRFDGSRTSVRGDRPPVSGGVGGLFRSLSRRNSSDGPRPAKLTRTMSLGSGEGKKKGFFGLGRRGSKSRPDDGGINGQWGVESDDEDGYFVDNHPSHAVRPSGLRGGGTYEHSEFSDDDEMHFTARPPQHTQTTGNQLAGPPRGDDEPDSMVRPFHRTPTGLSVKQLRKAERFTVDLEGGLDICLNVEVNSRDPTGITAPYRLLVPRLQYEYNPADDELQQPAKESQQPTGFKRFLSFRKKPEKPKLQQEHGHDGEESEDENEDYMSDESSDVPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3H7</accession>
    <name>A0A7D5Z3H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g025180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692578.1"/>
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    <dbReference type="KEGG" id="mbrn:26237508"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
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    <dbReference type="GO" id="GO:0006368">
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
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        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="58"/>
            <end position="128"/>
        </location>
    </feature>
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            <begin position="284"/>
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        </location>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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            <begin position="417"/>
            <end position="533"/>
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        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="164"/>
            <end position="218"/>
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            <begin position="222"/>
            <end position="233"/>
        </location>
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            <begin position="422"/>
            <end position="433"/>
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            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
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            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="677" mass="75392" checksum="8798C1C7B6E62587" modified="2021-02-10" version="1">MTDSKRKANGHSATEADDRSAKRRKLAEFDLSKGESRESTTAYGLAFLEQIRRTADKSGRLVAIYFENLLPREGNAEYYKRTRMPICLTSIEEKLNKGGFKNLAELESYFKRMIANAKEFYPRSSTVFEDAERVRKALSNYMTKTNPAYQTRNYQAVPTPLPPEDGEEVEEEEEEGDEDAEGEEEPAQEQEDEDGEEEEEEEEAEEAEEEGEEGDDEEPASRRRSIILKRSRGRPSLDLASHTNSPRRARPAGRPDHEYKNVPFKGLNFQQAQEKIVEELLRYKEPEYEGYFEPFVNLPPRALRDYYRVISDPLSLKKLQKEVLGIQGRGDPTGISDFKSWNALAERAKLLWNNAYFYNEEGSEIYELAQELEKAFNEQLKKAKAVVQEPAQPKIKLKVGQSIDTPSSSKKITILVGGRGSSVDSPTPQTAQSIEPPAGGSHVNGTARQPALDAARSASASMPSPSPSTHVGLKAEESARMSPAVLAQTPAEAPPGPPTPAVEAPPPAPPPPAGPPQIQSTNPMANGYVEPKRLRAPGKGIKDALISRLRIQLHPSMQPGDPVLLDVLPLPHEMQQSGTVNVPPIINRIFIVPMLPDLLQDRQYSLWVLIDKQPLKPCHQPIPNQLPQERAFDVMLHPGVNVIEAHLIAAIPRHERVPGGPEVELEVFTAYVNVLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3I1</accession>
    <name>A0A7D5Z3I1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g096160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546716.1">
        <property type="nucleotide sequence ID" value="XM_014691230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3I1"/>
    <dbReference type="GeneID" id="26241139"/>
    <dbReference type="KEGG" id="mbrn:26241139"/>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="161" mass="18480" checksum="B436CF77F3534D6F" modified="2021-02-10" version="1">MPRGTRAWSLFPEHHGSVEDLLQEEGLDFDFQHTDRESGHIKEYDTNVMGRFACPNANCTQQGWSSKKIAVWIRLYSGSRYNARVYNQRCKSCNSLSRPTLDDSYAERIAYRLKKWSNIEVKPPPSSGGNGKPHERDLCEGCKNGHCADGELKERMRSFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z423</accession>
    <name>A0A7D5Z423_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Polycomb protein VEFS-Box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g008160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549691.1">
        <property type="nucleotide sequence ID" value="XM_014694205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z423"/>
    <dbReference type="GeneID" id="26239135"/>
    <dbReference type="KEGG" id="mbrn:26239135"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21552">
        <property type="entry name" value="VEFS-box_ctSUZ12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="8">
        <location>
            <begin position="513"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="680" mass="75891" checksum="903E1749E1BAEB46" modified="2021-02-10" version="1">MGNIISSPMHKLPHGESDDGPPAKRRRISSPDSLDLDHLVASPRLSESGSTLRIEVLKILHKDSKKVKKYQGTPVPHDILTTKARCKVSMFDMSSGPPQILHCQSQLCDLITFKNPNGPYRIARVDLPAPFFVPRESILINRPDDGTFDLSDSYQLLIELEAANAAHWPPLDEQDFGIPTQSLYPPWGTTRHWILSSRFDSVFGRMRNPLSLSARYPSDQSSYQTNYVMDVDLRWTAGFKALRRLEKGSLPCITAIHPDVDMFSDNAMSHPGEYGLNGVNGHTDSASPQDQDDELAGDQTPSRSLRAREKNKIYNLKVLSDQALGRERKHRGRNSNTEINGEGRVQYILPSDQPISLEFYCCITCGACHDSMDELQLHLQTSHPTYKYVLETTSQGPLFRVAALRESTLSPRKALQLARAANPFSIQALISGDQNWAMSRLGPDGDEVFKSPTKNFLGRIQSGSPVSKFSKPPLRRPVKAASASKVLVPNIPQPLFHPISKAKLKPGQDVPQNTPDITWLIQKHRESIADFSDVTAAEKEYIWEWDGYILRQNITSAAYFPRAWLNFVEEKAGWLARAQHRMLEFGKHSSVLLARDVLDDEDMQQAFRYINEARAKSAKGQSPHGEMLAADDRAKGMASTKQSPKVSQIRKSANGCTICQLPVIGPRLLLCSNTVRSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4W0</accession>
    <name>A0A7D5Z4W0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="6">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">UTR4</name>
        <name evidence="8" type="ORF">G6M90_00g058040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="6"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544381.1">
        <property type="nucleotide sequence ID" value="XM_014688895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4W0"/>
    <dbReference type="GeneID" id="26242793"/>
    <dbReference type="KEGG" id="mbrn:26242793"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27502" checksum="552E55061D7F5A5A" modified="2021-02-10" version="1">MLARSFAGFSVIVLDIEGTVCPITFVHEVLFPYALRALPQYLDLHWHDSAFAQYRDAFPEEYRNDRLALESHVRDLVAADIKAPYLKALQGLLWQAGYDSGELKAPVFPDVALFISEAHSAGKKVMIYSSGSVPAQKLFFAHTTAQPSDLSQFITGWFDTVNAGPKTEASSYAAILSTHPDIEPSRWLFLSDNLNEVNAALAAGMCSLPVSRPGNAPLPPENSLSGMAIPDFSPESETKIQKSLATLTTGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4X3</accession>
    <name>A0A7D5Z4X3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amdS_1</name>
        <name evidence="8" type="ORF">G6M90_00g065910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540182.1">
        <property type="nucleotide sequence ID" value="XM_014684696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4X3"/>
    <dbReference type="GeneID" id="26246991"/>
    <dbReference type="KEGG" id="mbrn:26246991"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF11">
        <property type="entry name" value="AMIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="94"/>
            <end position="537"/>
        </location>
    </feature>
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        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="549" mass="60192" checksum="D7F50B634EC3121F" modified="2021-02-10" version="1">MTSATLTAVNATNGTNGRASWEQIGARKRQELLASIPKEWLIPADVLPAETEDDVTSWPETCGWFTAEELAITNASATELIPRLASGELSCEQVTRAFCKRAAAAHQLTNCLSETCFDRAIKTAKERDRHLEQTGKPVGPLHGLPISLKDNFNLEGLDATVGFVSLVGDAAKADSTLAQLLENAGAVFYVKTNTPTAMMIAESVNNVFGRTVNPLNRKTTSGGSSGGESALLAMKGSPMGVGSDIGGSLRIPAACTGIFTLRPSSGRFPVRNTRSGMPGQEAVQSVNGPMARTLDDITMYTKNVVDGQPWLLDPRCLPMPWRDVQLPNRLRIAVMWHDNMVRPTPPVTRALGEVVSKLQAAGHDVVEWDPADQKEGLELLGRMFVADGGTAIRKQLERTGEPWRPEMEQYRDAKELSTYEMWNLQLERVDFQNRYLDRWNRAGIDAILCPTIPFNTVKNGSFKHVGYTGVYNILDYSCLSFPTGLTVDKAIDRIEELYQPLGSDCEAINGDYDAETMHGLPISLQLVARRLEEEKVLAMGERVLEALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z517</accession>
    <name>A0A7D5Z517_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Low temperature requirement protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g066280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z517"/>
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    <dbReference type="KEGG" id="mbrn:26246954"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
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            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
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            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
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            <end position="316"/>
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        <location>
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            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49966" checksum="8AF1CB1C301A99E6" modified="2021-02-10" version="1">MNCDELQEGAKPQRYIIKRPKALQWFYNGRLYKESDEERQAGRFELFLDLLYVAIVANFSDDLAEFPNGAHLAKYILIFAPAWHIWADLREIMNSYYTDDLLQRLVILWVMALLVLYANNAREANTDIDAMRTTAGAYLVARFSTMSVFLISSFASYQHRTQARILAGFMFIGLFITIPLFFESVSIRGKAAVVAVMIVYQEVTWSITLSPWIKHRLRLKYSTAVDIAHEIDRMAAFFIIILGEFMYSVIVGDPAGIGLTAGYAKAVCTLIIAFCINWIYVSGDGSIQATHPIRRSAWTAFGFFLLHLPLSASFLIGGHICAISTRLHEFEQGQRWLLGGGLGVGMLCLWIYAQLYRTDGEDRLVLPKQLRVGMRLVVAVILAVLPETHDHLTTTAFMAVVMSLFAFLILWETIGGLMKGARFFEPWTDRHAPAEGDSSEALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5H3</accession>
    <name>A0A7D5Z5H3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684862.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246942"/>
    <dbReference type="KEGG" id="mbrn:26246942"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
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        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="353"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="353" mass="37781" checksum="D191496D40F369E5" modified="2021-02-10" version="1">MPQSGSSQKSTSPQTRPATPISDKYVGGLWIEGKRQLNREHDSSGKDTSTPLDGHGQVFAPDGPQKTPVDLASYIHNLHIGNEQVQNPHTNASTDRGDSIPGQSSGPYSNTSTCPVGIWDISKDVPASSVLESWIEEDLLNWGVGEGIDINDRLPPITNYVSVEEVEGTAATKKLQSDTGHVSSATVEVPGSLPPPLSAVGAPTVAESHTLPLAETEDTVATGNTDIDSPCSHKVPSASERPESSFALRDVSVIPWTDCYPDDPDKARELATSTGVPGLQIYSVYVFTHATSDTQVLDEVDATQDGHNFRVEMEPQPNDSVRASSVTDSERADESGWVKVEIETENPDQTDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5L2</accession>
    <name>A0A7D5Z5L2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G2/mitotic-specific cyclin-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nimE</name>
        <name evidence="8" type="ORF">G6M90_00g109190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543935.1">
        <property type="nucleotide sequence ID" value="XM_014688449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5L2"/>
    <dbReference type="GeneID" id="26243322"/>
    <dbReference type="KEGG" id="mbrn:26243322"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="255"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="348"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="352"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="485" mass="54161" checksum="E58665D518F68FC4" modified="2021-02-10" version="1">MPPGTRTSRQRLVSSENDENSSTRLTRAKAAALNVDELAMPTKGALQPKKSAANLGNAGVQRKRAALGDVSNVNKSEAVEGKKAGGKVGLVSKASHPTGVQKTTTRTATARSALGVKELNKAEARRGGSGTIGAGPKRKVASTANKDQDDVATGESQPLRKKTQTHKSVDLVRDENHAPVAQLKQETTDDEDKLVPPEGVNVIEEDDWDDPLMVAEYATEIFEYLRDLECRSVPNPDYMSHQDDLEWKTRGILIDWLIEVHTRFHLLPETLFLAVNIIDRFLSAKVVQLDRLQLVGITAMFIASKYEEVLSPHVENFKRITDNGFSEAEILSAERFLLSTLNYDLSYPNPMNFLRRVSKADNYDIQSRTIGKYLMEISLLDHRFMSFRPSHCAAAAMYLARMMLDRGPWDEILAYYAGYDKQEVQPLVDLMVDYLARPVVHEAFFKKYASKKFLKASILARQWARKNAALFGITDTELSLDQISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6U9</accession>
    <name>A0A7D5Z6U9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">set5</name>
        <name evidence="2" type="ORF">G6M90_00g070590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987006.1">
        <property type="nucleotide sequence ID" value="XM_066130935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6U9"/>
    <dbReference type="GeneID" id="26246492"/>
    <dbReference type="KEGG" id="mbrn:26246492"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
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        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF2">
        <property type="entry name" value="SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="488" mass="55650" checksum="9A5B8D6A2C6827ED" modified="2021-02-10" version="1">MYEIQDVPGKGKGLVATQAIPKGTRILSEKPIITVPEHTAMSSEQLATLISKQVDALSKNHQQEFLALRNIYTFNDVGQKYLGIIRTNGLPASDGEAGIFLQACRINHACDNNAQKNWNENIKRHTVHALRDIEKGEEITIYYMGADWDRETRIWKLQEQFKFICSCDLIRQGGLMGILSTPLQKLHYVDQQVRLYNERFPNGRGLARAFHSAAQIAIAHGDFARAQIFVDRALDGRICAEGDDTDDVIELKALAHKVSQDELDGLSMKWKTAVNDVPHGLDPADLEDWLWRREKPRQPGQLADLRDRTTFPAFPGLPHDETYYFYDPNELAGHSRRNWCFLAEIQRVTALIRLHFEVKDVDGETLPLFFHTDSRGMELERARVKEGFTVAVLQAKQHSFAFDRPGIRHEQPSRIKIFPVSLDKLMALSDRIQQFSVEANGTRDCQVAGWNKNGHKADCKLLKDEDLRSLFTTDWDKFESGIQFPLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Q6</accession>
    <name>A0A7D5Z7Q6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g108690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543979.1">
        <property type="nucleotide sequence ID" value="XM_014688493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Q6"/>
    <dbReference type="GeneID" id="26243366"/>
    <dbReference type="KEGG" id="mbrn:26243366"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF21">
        <property type="entry name" value="LIPASE_THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G02590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="112"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="39111" checksum="6EF4EA7BE7C56D65" modified="2021-02-10" version="1">MSPTALEPLSLAGKLDLIPGVLSLLAAGLVAAITGLWRTQRDAPTYRLHVAYAILRKSAERYSLAQLQWALPSTEQVYEQYARAAGFKPQTVSLGHGAKGHWVGDKHAKNVLIWYHGGGFGMPANTAFFEFWEKLVVSARTRDKDLAVFALSYTLSPHARYPTQLTQAVEALRYIVSQGRRPGSILLGGDSAGASLGMGVLSHLAHPHPAIQELKLREPLAGTVLMAPPASMDEKVAEGRDVYCGGDVLVPDVAIRWLHLYLGGAKRDYYTDPYDAPPSWFESLPVKKILVLGGGNEVLRPIIEAFVEKVKPTFPAIELFIGRREAHVAPVYNIFVGDRKETEQGRRLKDWLADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9G9</accession>
    <name>A0A7D5Z9G9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase swnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">swnR_2</name>
        <name evidence="5" type="ORF">G6M90_00g093740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540741.1">
        <property type="nucleotide sequence ID" value="XM_014685255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9G9"/>
    <dbReference type="GeneID" id="26246354"/>
    <dbReference type="KEGG" id="mbrn:26246354"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="304" mass="34451" checksum="BA64F5E90BFC9C77" modified="2021-02-10" version="1">MKVAIVAVGDLARYFVEELQKSGHEVLAVSRTPKTYLEDLEISQHITDYSETDLTAALADCDAVVCTLRVGVPDYVAVHLAILRACQHSATCKRLIPATWAGNLEDFPDEPLGVADEIRLVLSALRSQQDVSWSSISPGWYVDYIVPEKQRFMSSLGDMWPQNYDRKTFTIYGDGTQLVNFTSARDTARATVRLIEHNREDWEEFTFISGAQMTWMELGRFIQSRDPEYAFQNKSLSQTIKQYIAQESLESYGAAILELWGHGAGVRFPWSKVERHRAKFFPDLKFRSVQELADEAASEPNKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9K1</accession>
    <name>A0A7D5Z9K1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SCAP</name>
        <name evidence="19" type="ORF">G6M90_00g095700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546760.1">
        <property type="nucleotide sequence ID" value="XM_014691274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9K1"/>
    <dbReference type="GeneID" id="26241183"/>
    <dbReference type="KEGG" id="mbrn:26241183"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="286"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1090"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI73107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123548" checksum="8CE83BB0A7F2A617" modified="2021-02-10" version="1">MIWYFLYPLRGTTEPPDLAPSHSLRRGFARYGRYVAGHVVTAVFISATVATILIYPIPYLFTSDFVNGASYLPHHAWTVAQPLTYDAAVEPDIIMRSIWVHSSYMEALNADLLASALELQNELLGETENFSPRDAPDNLAKHQDDDQLSLAQRDALHISNGLTNQSWFFHSPLLYWYSSRDRLLADHDILSTINDRKNQSNFSNTTLRHSVVFSGKRFEDRRLVAADAIVITLLCLGDSPVGQEWETKALSLPEKVSDKFDVYPSDGRYARSQLYEFQFRPMSPQDILSLAFAYGFAVLYFLMSLSKLRAVKSKIGLIVTIITQVALSIMSSFTVCAIFNFDLSRIPQAAYPLVVLSMSLENIFRLINAVILTPSEDSTSNRIGHAFGQTAHTALASSLQNVLILFGLSRVVSPGVSAFCIFAAVAIVFDFFYLSTFFLSVLSVDVRRMELGDALAKAALRQSRRKYQGNGRGPLADGFFQGKIAWSTRIAGTVIMIGFVIIAQWHFFGDDNMFRKLLRLYRGTDSNLLRTPDLSVLKGLHQARSHTSWLRNQDHETAKEIIRLIKPGAYSYVARVFEPLVFVKRDSDRTPHSKEPTLLPAAYDFIHHQLLRFIVIVVVIVAALRLLMNYLLWGEDAELANGGEQDDTPLVSIKSMGGGHVLDVALLSKSKAGHIVSVGLDRVIRVWNIRRGSSYVIADGNDAELCPFPILGMSIGGNSTWLALLSTSRVSFWNLAEQRWGESMPLENCSHRPAAMFFDSTPDTDKPTIQLVHHNGTMVQVTAGTQIPESGISICPEPLALARSLTKKCDSGVITFIVMVSKKGHVYIGNRQESSWTTHLLDLKISDAGAISQIVPLSPLGVFALAASDCVYLVDAEVREVLRTLLTERMISRSLQCTYSGHASKPGMLGLASLTLCYVKSETGDCVLQAYVPADDCEVIHLRSPDSKMNGDECSFESAKEVKKRVKNPGTWHLLSDGSVVGIRRAIQTYNKISNMNSTLRRRRATGQNNQYSFANWEVWATSPCDKPDLEESRPLFELGDESSHLVVSDLGPKVSVGLRSVAFTFGNVIKLVTAGALEHYDVDPENNSYDALMNTSSRRRKPGQAARIRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA71</accession>
    <name>A0A7D5ZA71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g095170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546813.2">
        <property type="nucleotide sequence ID" value="XM_014691327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA71"/>
    <dbReference type="GeneID" id="26241236"/>
    <dbReference type="KEGG" id="mbrn:26241236"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="443" mass="48854" checksum="B8B4B6B8E643E893" modified="2021-02-10" version="1">MAKSDQGRHFLAGKTIVVAGAGIAGLAFAIGLRKQWKHGQKQPTVIIYDRDSPGSDAWRQGQNYTFSISGYSDAGGLVALKKMGIIDAVFSSAVSGIDGSGSFTIWSPDWGERFRSQRPPIAGLPTPSIRIVRKELMRILTDEWESFENSSIQWGTQCVNVAKAPNGRLRVYLREIRQGEEAGETHTECDVLIAADGANSKIRRVLRPHDDLEYIGAVLRGGLATFPEGVPSPVDKDWGFVMGNTGVTCFISPVDRNTVIWAVGNLETEPVKELTREQGKEERRAVVDQAAALGHIFHEPFPTMTRQTDPGSVLCINGRDKQPFRHGDISDVPVVFIGDSNHALSPFAGFGANLALSDACDLAEQLCQSHESLARAVEAYDQISEPRARRIWTESRKNLRAGHSTGVRYWFFVCLLCVGDWMCVVSLSWYDDFVLPTPEDYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAH6</accession>
    <name>A0A7D5ZAH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-induced degradation protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Gid4</name>
        <name evidence="3" type="ORF">G6M90_00g110180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543840.1">
        <property type="nucleotide sequence ID" value="XM_014688354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAH6"/>
    <dbReference type="GeneID" id="26243227"/>
    <dbReference type="KEGG" id="mbrn:26243227"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="39866" checksum="333B9F2004B9266C" modified="2021-02-10" version="1">MPTPSPNQPPDQPPSASPYPFSTCPDDILHTTRHDLDNHSGPAPDGLSPANFGLESQRSMQRTVETATDNRASESPSSRDTTVSPAPQTSTTAVTSPESRGIDAGHTMKNPELGPDGPTPHTASSRPSQSLEQSPKDLGGPDLAMFEEEDVACTPPSMGSDYSSARAIPFAPLSFLQPGSRFHGTQQSERQVYDVQVEIKHVDMRESFLCGYLRIQGLTEDHPTLTTYFEGEIIGSKYSFFTQHEDWGANMRVDLSHWAKFNAFRPFQKHARKGPVTIPDVTQRENIFMRWKEHFLVPDHRVRTITGASFEGFYYICFNQLKGEVSGIYFHSKSEKFQQLELKHVPNRGCFSATEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAP8</accession>
    <name>A0A7D5ZAP8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SPS19</name>
        <name evidence="6" type="ORF">G6M90_00g102490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546098.1">
        <property type="nucleotide sequence ID" value="XM_014690612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAP8"/>
    <dbReference type="GeneID" id="26240521"/>
    <dbReference type="KEGG" id="mbrn:26240521"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="297" mass="31235" checksum="9E607DEEBE7D376C" modified="2021-02-10" version="1">MSYPESHYLSPIWRDDLFKGRVAFVTGGAGTICSMQTRALVRLGADACIIGRNVEKTEKAAKDIATVRPGAKVIGIGGCDVRKVESLKEAAARCAKELGGIDFVIAGAAGNFLVSMEAMSPNAFKAVMDIDVLGTFNTIKSTMPYLLKSPDARIIYVSATFHYTGMPMQGHVAAAKASVDSLMASVALEYGPRGVTSNVISPGAIADTEGAARLLTGDAAALKHRARAIPTGRLGTVKDIDDATVYLFSSAGSHVNGHVLVVDGGSWRRQGSLAMGGEDVKYPDFLLADGEEPKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBS0</accession>
    <name>A0A7D5ZBS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539781.2">
        <property type="nucleotide sequence ID" value="XM_014684295.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBS0"/>
    <dbReference type="GeneID" id="26247446"/>
    <dbReference type="KEGG" id="mbrn:26247446"/>
    <dbReference type="OrthoDB" id="5134445at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38575" checksum="D4FDB38F75D6C603" modified="2021-02-10" version="1">MSSTTTPVAASSTAWTPIPYVPGRTMNLKTSCGKDIQLTITRVCSVTVSPVMEVQLRKPDGCRTAILKLFDRRFGHSREKHPYNQQAEAAWQDSVRSGLAKRLLDDLRNDEDSVRRARFQKDVDEGDSEEEEEEEEEEDDDDDDDNENDLAESEAIIYHTARTNYENEVRAYSQLKPLQGRCTPRFIESVIDSSPESPADLPVEYFQVPGIILEYLFGFPLSELTARIPNQPFLWEKIVQGAIDVVREVNMAGIVHHDCQPRNMMVSQIGRDVFRLYLIDFAQYAFRADYKDTDDLFDENGFAHIVNLYDNHGGIAILMSQRVKRETSYTLHLKALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC15</accession>
    <name>A0A7D5ZC15_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PTC7</name>
        <name evidence="4" type="ORF">G6M90_00g085780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541137.2">
        <property type="nucleotide sequence ID" value="XM_014685651.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC15"/>
    <dbReference type="GeneID" id="26246126"/>
    <dbReference type="KEGG" id="mbrn:26246126"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="40189" checksum="D128F7AEAC4BB775" modified="2021-02-10" version="1">MRQPTPDAPRKSPYSTSSASFPTSPRFSYHIAASFIGKDRPYDPSTHVFHFNPYNRIQPPRHRRRSSRPDSGHDAFFVSRINDSGSVAFGIADGVGGWVDSGVDPADFSHGFCDYMAASAYEHDPANSPPLTARRLMQHGYDAVCNDRSLQAGGSTACVGIAAPDGTLDVANLGDSGFLQLRLNAVNAYSEPQTHAFNTPFQLSLIPPSVAARMAAFGGAQLSDLPRDADVSQHYVRHGDVLMFATDGVLDNLFNHDILKIASRVMVSSGAWQMTPSGGVRVADSIDSLTRPASLAEAEPNGKPPRTVTLQSLLATEIVGAAKTASINTKVDGPFAKEVQKYYPHEQWRGGKVDDICAVVVVVSEDNSGSRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDU5</accession>
    <name>A0A7D5ZDU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g113130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987787.1">
        <property type="nucleotide sequence ID" value="XM_066131881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDU5"/>
    <dbReference type="GeneID" id="90968287"/>
    <dbReference type="KEGG" id="mbrn:90968287"/>
    <dbReference type="OrthoDB" id="5244652at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="166" mass="19459" checksum="BB9D64977C551236" modified="2021-02-10" version="1">MEWVEKQLKWLQEMDPHNKLLVVWCRYPDLRTGHDPFDLGSRFWMCLDSSATPSFEKLIPIKIKEERLRMAGRMTVFACGDAYFTALMRDGTIKILKDKPVKFLESEYQSRSLVRVSSVEGPRRGNPRKRKKLRGHTERLELQNMANNRQTTYSPVSEGSFYSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQI4</accession>
    <name>A0A7D5UQI4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g008910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549620.1">
        <property type="nucleotide sequence ID" value="XM_014694134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQI4"/>
    <dbReference type="GeneID" id="26239064"/>
    <dbReference type="KEGG" id="mbrn:26239064"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="57"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="278" mass="29438" checksum="A0FB668D28DEAF17" modified="2021-02-10" version="1">MSHSHSHEGGASHSHSHDGFSAQEHGHSHEILDGPGSYVGREMPIVEGRNWSERAFTIGIGGPVGSGKTALMLALCLALRQKYALAAVTNDIFTREDAEFLTRHAALPPQRIRAIETGGCPHAAVREDISTNLAALEDLHGQFSTDLLLIESGGDNLAANYSRELADFIIYVIDVSGGDKVPRKGGPGITQSDLLVVNKTDLAEAVGADLGVMERDARKMREGGPTVFAQVKKDVGVDHIVNLILSAWKASGAEEERVQQGGPRPTPGLDGLDGGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQS9</accession>
    <name>A0A7D5UQS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g017920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548741.2">
        <property type="nucleotide sequence ID" value="XM_014693255.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQS9"/>
    <dbReference type="GeneID" id="26238185"/>
    <dbReference type="KEGG" id="mbrn:26238185"/>
    <dbReference type="OrthoDB" id="4940825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="53174" checksum="E02D32EADB7273D8" modified="2021-02-10" version="1">MAAEFTMRSPLERLPFEVLGMICAFLPRADLKALRLVSRAFDGPSLSTLFRTVYLKVHLGSFEKLLDISRSEKLNKHVRYISYDCRVLNASRVSPDLADWVAKTACDGLCSRYHHMLKDDNENRMLRDALQNLPRLLGVESRMPDPREMSRVLPPSERAWSQNSLSTVAQKILVEPPPLDGGEREATRHFWALLQSACLAGHAERLTHIHGEYMELNSWRDAAASCLANYDEGFPSLQHLSLSFNDYEHSDEATDYIGGIIADAPSLHSLLLYFDNGDYMPFCELVWPDVELHHLRSLSLFGLCVTETQLRDGLGAFRGTLRSLELADISFVPGSWVLFFRFLSKEMTLDHVKLYEFFTNYRDEAWVARDERQSPLPALAGASARDSRKYLVYRIERFITGRGRYPDPFTPRKKRDGDLEKYGYSLPWAFKQDRSWYHADTVWSAREWENTYPLATKWTLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQU8</accession>
    <name>A0A7D5UQU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g013650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549157.1">
        <property type="nucleotide sequence ID" value="XM_014693671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQU8"/>
    <dbReference type="GeneID" id="26238601"/>
    <dbReference type="KEGG" id="mbrn:26238601"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40470:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G15850)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33159" checksum="6BFF71C7ACD6E64A" modified="2021-02-10" version="1">MTQPTLLERLNRDGFVVVPKAFTGETLEKLRQAASAATSNARHGKWPDVRTLPKQFPPWKIDGPNPAAEGIWGVQGVMHPDMPFQEEFIKVYFSDAIIDPTLQLLQCSKDDLVMELFNLLVRPDYDFELRWHRDDIPPTASAQEELDRLNKPAFSAQWNLALYDDASLVVVPGSHLRARTDTERNADPYEKELPGQLVVKMEPGDIVFYNNNIVHRGVYDANVERMTLHGSAGHVDGATLRARNVLQHGLRNWIDRLHFDALQGEEKKLAEHMKENLVKMGREAGDVGYSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR33</accession>
    <name>A0A7D5UR33_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g020620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548485.1">
        <property type="nucleotide sequence ID" value="XM_014692999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR33"/>
    <dbReference type="GeneID" id="26237929"/>
    <dbReference type="KEGG" id="mbrn:26237929"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028990415" evidence="2">
        <location>
            <begin position="23"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="395" mass="43523" checksum="5B1FED884FEB4907" modified="2021-02-10" version="1">MPATKLTNGLVAILGLTSMVYSEKSSKGDLILCDCGIGDDKEHPDWSTSRQMNWYKDIKWPASAANYPNAPDMAVQVPYKDGIYPWIPQGVTATMPNGEVWTAYIEDGTPDGFKAGSAVSSKDGKNMLNCWAYRGRPVSAAINKTVSHDAICWTAFVCNHDNEPPSRPDDMDHPSTMTSSTATPATTYYTKPPKTVTATVTTTSGQPVPTYNPNKGTLSIYAGVNPRFINWQDTWQSFINHFVWDKNSGRCIGEPARGIGYNITIDCAGIQIDEDTHMTLLLIKALRDVGLNSLWFNQNPVIPGGNGPNNTSPNWVVMPESFTLEATDLGTNNVVGRLAYKTHYDNFLTPPCSICEIGRFDKNFFNPIIESMKGSYPEFNNFTIKGQCDPWIACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URV7</accession>
    <name>A0A7D5URV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Picolinate carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">acmsd_1</name>
        <name evidence="13" type="ORF">G6M90_00g022020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite metabolism; quinolate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548350.1">
        <property type="nucleotide sequence ID" value="XM_014692864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URV7"/>
    <dbReference type="GeneID" id="26237794"/>
    <dbReference type="KEGG" id="mbrn:26237794"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001760">
        <property type="term" value="F:aminocarboxymuconate-semialdehyde decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF27">
        <property type="entry name" value="2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="59"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="421" mass="47283" checksum="CFC24E048012C45C" modified="2021-02-10" version="1">MSLIASPPSSSARLPNMQFHEPLIKVAACDCMSGNTDKEFASHTSHIEGTYPSKTGFRIDIHTHIMPPSLPDMSQFDDSSNRNEWINLRLHKPSPSSSESSSPSQKLDMYVGRRFFRTVEANCFDPETRIKEMDASGVSVQVLSTIPVLFSYDKPIKPAAMLARLLNDHIASLCRVYPSRFVGLATVPLQDVAAAVEELKRVKGLGLRGVEIGTEINGRELDDLDMEPFWKACEELDMAVFVHPLGYELARENKRWANYWSAWLIGMPSETALALHAVVSSAVLVRHPRLRLCFAHAGGAYLPLLGRIQHGYDCRPDLVAHKAEGVSPTRQVALGQRNIWIDSLVHDPDLLEYMCKKIGPERVIMGSDYPFPLGEVPLPGQMISTDERVRGFLSEERREAMLWRNAVEFLGLHDLVREYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US56</accession>
    <name>A0A7D5US56_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g012440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549278.1">
        <property type="nucleotide sequence ID" value="XM_014693792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US56"/>
    <dbReference type="GeneID" id="26238722"/>
    <dbReference type="KEGG" id="mbrn:26238722"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12563" checksum="01FE81E2BE30E533" modified="2021-02-10" version="1">MLRTTFSKTAAFRPLRATFTTTARAMSEGDTGAPPKTGGPGPLTDWGDWFLYSDAFQRRERASEDWAIRQREKERLLELKKKLAEQQQHLQRLSDHIEEITRDQGGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USF9</accession>
    <name>A0A7D5USF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g025160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI65613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692580.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="106"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="180"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
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            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI65936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="399" mass="43783" checksum="FD626932190B0E29" modified="2021-02-10" version="1">MSFPYNDWTSVAESQRGFPNHAHSATNRQPQQSPGLQSAKTGSNSHPFSQPYGPPPTASRSIGGDVEFMSLQSSAAPFLSGHPSSVNIDSRLHTTSALTTTDLFPPPYHKNLHRSVHSSELPFDTNKPQHPVVIPTKEPPSCQKKTQAQSQLSGQSLRGLGGSGTSNIPNLLGPDRVDVVNGIMFRLSMRQQPQAARACGFGDRDRRVIDPPPIVQLYVDGPSLSKDEAKSYLRYESYVMNCSICDESGTQDASFMPEEYQHQRRLMGSLVGTPFVGMDDHGEEGCFFCFSDLSCRTPGAFRLKFTLIMIDPARAGVIRHFPILTEIVSDVFHVYSAKEFPGMLPSSGLAKRLKEQGCIISIKKGNDRTKNARGQDELSDEDGAGEGSQGQRKRRTVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USY0</accession>
    <name>A0A7D5USY0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PNG1</name>
        <name evidence="8" type="ORF">G6M90_00g025430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI66235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692554.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26237484"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="254"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="471" mass="53388" checksum="F4B781BA994BE33B" modified="2021-02-10" version="1">MEGRGTPFDSNPSSSDGQYGEEWARDLRLKFEGLLRDKRMNDLRSCTRSHSPRHQSPGLSGRASSANLAAHASFTDNRPATAHGSETPSTPPSYSCIRHLPKIPTAPAAGDRDSQKFRNLMISLSLTPTKYENPGLLDEALQTIPLDRIYSEAEEECQVLQAEAESMGDGRRPEWGYQDCVIRALLRWFKRSFFTWVNNPPCPVCLSPTIAQGMTAPTPEESACGALRVELYRCSAQNCGAYERFPRYGDVWRLLQTRRGRVGEWANCFSMLCRAVGGRVRWVWNAEDHVWTEVYSEHQRRWVHVDACEEAWDSPRLYTEGWGKKMSYCIAFSIDGATDVTRRYVRNNESAAERNRCPEEVMLYITQEIKNIRRSNMNKDERFRLEKEDQREDEELRGYVVASIAQAVTDLVPGASSSSSASTGRIVPSHGQDVKVPAEQLVQQTGSAAWLMAQQQARNQQFQPPRDPRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT10</accession>
    <name>A0A7D5UT10_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PLA2G7_1</name>
        <name evidence="7" type="ORF">G6M90_00g027060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547880.2">
        <property type="nucleotide sequence ID" value="XM_014692394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT10"/>
    <dbReference type="GeneID" id="26237324"/>
    <dbReference type="KEGG" id="mbrn:26237324"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="586" mass="64800" checksum="15EAC511591EE068" modified="2021-02-10" version="1">MTLRERFLHRLPNYNGPYNVGYMDVEVPARNPRPISNLKRGGKPVLRLDTVLMGIYYPCDVEKTIQASGGAHNLRRVNWMPAPRIATSKGYAKFLNIPAAPVTGYLACTSLFTKLPAFRNAQLADSWAENGPKEDVACDKEDGGKDGCDSEKPTFPVIIFSHGLGGSRLCYSTICGELASFGFIVVAVEHRDGSGARTLVNLPENVSATEIESSTAEIVSGNDEEHGSEAGAGARKKKVERKTKRGVNPYYIMDYILPKDNAQDTSPHNPRGVDRHLRNAQIELRLEEIKEAYHVLSLINGGRGHDVARLNLRKKGNIGSSSRGLTGITWDSWKGSMFLDKVTAMGHSFGGATTIQLCRDQSLAWLGQGVILDAWGQGTPARGDGPGNIVAKPIIAISSEAFMHWKENFERVVGFCQEARESKTLCWMLTIVGSTHLAMTDFAVLYPHWMSFFMKSMVNPLRACSLTVATSLEFLSLTLPPGHIKHKTWADEDLLLSAPAPSEPEEALIEDHAPEYKWVAVRLKIPNEFSKRFKAWCRRLWRTLMCNAVEGDALGNGLHDYTEQDELWTHISPRCADVASYRSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU06</accession>
    <name>A0A7D5UU06_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">srb-7</name>
        <name evidence="12" type="ORF">G6M90_00g024020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986140.1">
        <property type="nucleotide sequence ID" value="XM_066129929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU06"/>
    <dbReference type="GeneID" id="90967519"/>
    <dbReference type="KEGG" id="mbrn:90967519"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="65"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="138" mass="15907" checksum="ECB02E43CE8B9E81" modified="2021-02-10" version="1">MGDRLTQLQDAVDQLAQQFVACLHFVQRRHDLETLGPNDKVRDIKQEPHQREVDPLPADEFAAGLKELSRDLIIKEQQIEVLISNLPGLDNSERDQERNIKDLEEDLKAAEAQRQDALKERDHILAELDSVIRSVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU53</accession>
    <name>A0A7D5UU53_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g016220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548906.1">
        <property type="nucleotide sequence ID" value="XM_014693420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU53"/>
    <dbReference type="GeneID" id="26238350"/>
    <dbReference type="KEGG" id="mbrn:26238350"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602:SF2">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028857735" description="GPI anchored serine-rich protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="25496" checksum="0EEB47C5DCCF6ED2" modified="2021-02-10" version="1">MRFTAAAAALMAGSAIAGDVSTDYTTQLVTITACPESVTDCPARSTQVQTSVVPLTTSTVYSTKVHTITSCAPQVTNCPAHSTIVSTETVAVSTTVCPVGPTSVPVPVVPVPTVPGHGNNSTGVVVPPPASSHVVPPPASSGPATQGPPPAVSTNSPVTQAPAPPACPAPSVTAITKSYTTVLTSVEYSTIEVPCPPTGTVPQGTGIPPVPTGPANPPSGGNPPAGGNGTTPGGNPPPVTAGAASFAGSAVFAAVAGIAAFVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUU8</accession>
    <name>A0A7D5UUU8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g041640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986372.1">
        <property type="nucleotide sequence ID" value="XM_066130286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUU8"/>
    <dbReference type="GeneID" id="90967671"/>
    <dbReference type="KEGG" id="mbrn:90967671"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="154" mass="16348" checksum="F60F76DFE85B6535" modified="2021-02-10" version="1">MASAIPPSPVKPFAAVEVDANADQQTAPPRMMPMATPIRKPRTIFSPFDPLVTSCKILSPTLKSPNPFGVDPQDVIVGSVYVVEGHVVGTPPDEVGVGVGVVDGVVATDAVPLVKFVLVMVADSSDLCSTPRPSLFFFLFFYFSCLLGPALRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVA8</accession>
    <name>A0A7D5UVA8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">aorO</name>
        <name evidence="15" type="ORF">G6M90_00g051230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539809.1">
        <property type="nucleotide sequence ID" value="XM_014684323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVA8"/>
    <dbReference type="GeneID" id="26247364"/>
    <dbReference type="KEGG" id="mbrn:26247364"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028973946" description="tripeptidyl-peptidase II" evidence="13">
        <location>
            <begin position="20"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="14">
        <location>
            <begin position="237"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="650"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="673" mass="73087" checksum="44F4FBCBDD2CA090" modified="2021-02-10" version="1">MVKLSIAAVVALASASAWALPSNNHVLHEARNPTSTRQNHLWKRGNRVHPDAVIPLRIGLAQSNLHEAYGKLMNVSDPDSEHFGKHLAQDEVHALFAPSDETLTAVHSWLVDMGISKTQIRQYTNKGWLALDVPVSKAEELFQTQYHEHEHDGAIKIGCDEYRVPKHLSQHIDYIIPGVKLSPLMVRRSAKARSPAKRITAQNRKNWEPKKVSRKKPSCKTPPPSNLPPELKDCARNFTAACYRALYQIPLANTPVPGLEPAVYEIGDTYSQEDINSYLHKYTPYIPNGTHPTLHSVDGAQAPVPPQSPQNTGESDIDIDIVQSLIWPQSMLLYQVDDIYYSTQSNTSGFLNTFLDALDGSYCHKTDFNITGDSPGIDPSYPDSHPGGYKQAEMCGAYKAAPVISISYGESELDVPKKYMQRQCNEFLKLGLQGTTVLVSSGDYGVGIGPGANACLNGSGQTNTVYNPGNPVSCPYLTAVGATQLNPNTTVRDPEAALQTPLPGAELFASGGGFSNYFPVPEYQRAAVRSYLARHDPGLRSYVADADASNIGAGGGVYNRAGRGIPDIAANGANFRAFTNGTDQHVFGTSLAAPLWSAVITLVNQERARAGKTTVGFINPALYKNPAALTDVTRGSNPNCGSSGFSAVRGWDPVTGLGTPMFEELRRLWLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVB7</accession>
    <name>A0A7D5UVB7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g036680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547059.1">
        <property type="nucleotide sequence ID" value="XM_014691573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVB7"/>
    <dbReference type="GeneID" id="26239622"/>
    <dbReference type="KEGG" id="mbrn:26239622"/>
    <dbReference type="OrthoDB" id="4869833at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028962151" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="59" mass="5897" checksum="97D5B5B9C95205AE" modified="2021-02-10" version="1">MKCNSIALAALAFIAGSVIAAPANIESRDIPLLGGHSGPLQGLGETLDSIEKLVPGLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVP3</accession>
    <name>A0A7D5UVP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dbr1</name>
        <name evidence="15" type="ORF">G6M90_00g051470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539832.1">
        <property type="nucleotide sequence ID" value="XM_014684346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVP3"/>
    <dbReference type="GeneID" id="26247387"/>
    <dbReference type="KEGG" id="mbrn:26247387"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="329"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="487"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="59437" checksum="D9BE333F77CD020F" modified="2021-02-10" version="1">MEVNGVRVAVEGCGHGTLNAIYAAVAESCKVRGWHGVDLLIIGGDFQSVRNAADLTIMSCPVKYRHLGDFPDYYAGTRTAPYLTIFVGGNHEASSHLWELFYGGWVAPNIYYMGAANVLRFGPLRIAAMSGIWKGFDYRKTHHERLPFSGDDVKSFYHVRELDVRKLLLLQTQVDIGISHDWPRYIENHGDAAWLFRKKPDFRRESQNGQLGSIAAEYVMDRLRPPYWFSAHMHIKFPAVKKYTDAAPVAPSTNVNGDEATVPEGGANPDEIDLDMEDDENKSTEKPATGAEASESKATNQISAELRAQLPASFAKPPPRDNRTPGQPVPPGIKNREVRFVALDKCLPGRHFLQLCDIAPFNAADLAAYPPKSSGPRYQLQYDPEWLAITRVFHSTLSIGDKTARPPPDLGEEHYLPLIEAERAWVEETVVAKGRLDVPENFELTAPPHAPGSPEIVDEQPEEYTNPQTTAFCDLLGLKHLWNASAEERKARRDQGPPPSEYQGRRGGAGGRGGRGGGRGGGRGRGGHRGGHGHRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVT5</accession>
    <name>A0A7D5UVT5_9HYPO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g032980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687741.2"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26244028"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="313" mass="36663" checksum="CF4CAE2DF754C052" modified="2021-02-10" version="1">MHPPSLGSILWSALWQPDIDCNLVSPWLASFINVLDHIINDRKLEILVKVLALRRPRVGIWWLALFLLGDLEIVHWFRRYAETLMEKRASATLSAPDPVVSAWTGSKQSFLDYDKTKRYKGLNDLVSREDLLRCRLVFNSQDRYFASLSWRPFGHIAMRNVELELWPYLESDYAFVYDSFAWYQDGKLLHVSRGFRSETGRHVKCVPDDLERRRSETNCHTGCHHDIKLEPSRISTLNMLSRAIYDATGGRHWANTALPATSRQHWWLRDWEGLDSWDRSIKLNREADNAVKPPSRFLLDWIRRQTQDSQANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW63</accession>
    <name>A0A7D5UW63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor vib-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vib-1_0</name>
        <name evidence="5" type="ORF">G6M90_00g038670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW63"/>
    <dbReference type="GeneID" id="26239786"/>
    <dbReference type="KEGG" id="mbrn:26239786"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="82"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="82"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="517" mass="56915" checksum="B7FC8772B0DFC288" modified="2021-02-10" version="1">MATFNSMPAMSAAAPNEAMGLNHPAPGQPMTMEHFDQDFNFDEAVLDGAPLPTLPFTPAYDFDNFTTTFEDPFAYSSRAFEPTPNQDALNEESSPQELDNKLLGFSDPIMNATVVDKTGKLAEVNMSAELYGMFFVAEDVFGGDNSGRPLELTCYRRNLWQCSGQITLPKNLSHLMDERGRQFSIDELSASITAVESIEGKSTEIISIPWKSSSSQAPEETKVAAAPPQIPLDLSTAQEVDAVRVTLPVSWKRLQFKHATANNGRRKGLQQHYVVQINLVAKSKSNDMMKIAEIQSGPVIVRGRSPRNFDSRKDVPLTGEKRLEKKNTASSDNTALKIERENIQATMQRFQPLGNVATPAEWSANPQHVSHPNSQSPHPAKRMAVSPTVARPPVPSWSADGKSMTTGQPHRGSLSRQNTAVPINLSLSEDEKSPNRSSAELQSPQMGKSHPVSGQNAGNSPVDDPDPLYEYFPLTLDDWMPPIDAVYRPHVVHHTIVPPEIKAQQSQSKAKRYFSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW73</accession>
    <name>A0A7D5UW73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g058650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986642.1">
        <property type="nucleotide sequence ID" value="XM_066130669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW73"/>
    <dbReference type="GeneID" id="90967821"/>
    <dbReference type="KEGG" id="mbrn:90967821"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8482" checksum="EB11A43F0AB3886F" modified="2021-02-10" version="1">MTRDHVVHAGVDNGTVARSGRTRGDSESSVLQKIACIKGRAMGNERGPNTSRTFEMQANMSTSAEWQPSYIFPLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW83</accession>
    <name>A0A7D5UW83_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g041530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547498.1">
        <property type="nucleotide sequence ID" value="XM_014692012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW83"/>
    <dbReference type="GeneID" id="26240061"/>
    <dbReference type="KEGG" id="mbrn:26240061"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="200" mass="22166" checksum="3D55F5EA2E0106BB" modified="2021-02-10" version="1">MESTRSNDTTAKAPPFHFSHDASLAQFSVPFKSWIQTNGKPWDGVATGALVFDARGRVLLVQRTSHDSMPDLWEVPGGAVDADDASILHGCARELWEEAGLAARRVARLVTEGPGADAFQEFRNSTRSKLIGKFQFEVEVEVADGQAVRLDPNEHQDFVWATEDEVEREEVGGKKIPITKRSHKLVILEGFRLRKGAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWH5</accession>
    <name>A0A7D5UWH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPI18</name>
        <name evidence="13" type="ORF">G6M90_00g036400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547032.1">
        <property type="nucleotide sequence ID" value="XM_014691546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWH5"/>
    <dbReference type="GeneID" id="26239595"/>
    <dbReference type="KEGG" id="mbrn:26239595"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="46372" checksum="82B43969733B8928" modified="2021-02-10" version="1">MDLFSSSQPIRSLTALFIAWKGFLLAVSLGAAVAPDYDTSTSLFFDRMYGHNITIPTIAARLTRWDALYFMHSTIRGYTYEQEWAFGLGLPTTVGAISRSLSSLTPANYALEPLVAIALAHASHFVAMLALHRLTMILSGNAKLAFVSSALHILSPAGLFLSAPYNESPFAGLSFMGNLLFAVSLKSKANGVKRNVTMLASGILFGAATAFRSNGLASGLLFAVQAVDALLLFARAPSLCTLLSMIAPVLGGLCVAAGSVVPQTVAWMRYCGSDGVGRPWCEKMIPSIYTFVQDHYWNVGFLRYWTLNQLPLFLLASPMLAILIKSGLDLISKPQRITTASRNGAAESDLNTFVRALAGSQALIAILAITTYHVQIITRISSGYPAWYWWVGSCLMDKRRQGYGVAIVMFMVMYGSIQGGLFASFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWS0</accession>
    <name>A0A7D5UWS0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-splicing factor sap61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sap61</name>
        <name evidence="10" type="ORF">G6M90_00g063390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542544.1">
        <property type="nucleotide sequence ID" value="XM_014687058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWS0"/>
    <dbReference type="GeneID" id="26244493"/>
    <dbReference type="KEGG" id="mbrn:26244493"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="503" mass="58467" checksum="9A86AD9528B22D49" modified="2021-02-10" version="1">MYVLEEQRYIHEDLERLEQGIADRVREEPKPIRDRLNRDHEIAQLLDQIQRQSSSLLNLYKDENGTRAGELQELNTGDPFDAFYKQLGDIREHHARYPNEQAENSEQRYKQKRGDPSAPVATVVDTIFSGEEAFGRFFDLHTCYDSFSNLPNVKRLTYLQYLEYFDNFAAGYGGVKRGDKMTDQYFNYVGELAQYLEDFMRKTRPLENPDNILSGFDEEFGKLWEKDEIEGWQIESATNGSKATLTDAEAIWCEDCEKEFKNENVYKNHLTGRKHIKAAEQRKQRQQDAAAGSADSKSVVVSSARLKERAIAEREYRVKKMASLMNTERSDTRVNVERKQGMTKREREQELENLLNASDTPREAAEDGEGEGDDDEDKIYNPLKVPLGWDGKPIPFWLYRLHGLGVEFPCEICGNYVYKGRRAFEKHFNESRHIYNLKCLGITNPTLFRDITKMDEAVKLWEKMQKEKKKSKLDEGSVVQMEDGEGNVMPEKVYYDLQKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWT0</accession>
    <name>A0A7D5UWT0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone-lysine N-methyltransferase EZH1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EZH1</name>
        <name evidence="10" type="ORF">G6M90_00g058840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544458.1">
        <property type="nucleotide sequence ID" value="XM_014688972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWT0"/>
    <dbReference type="GeneID" id="26242870"/>
    <dbReference type="KEGG" id="mbrn:26242870"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048360">
        <property type="entry name" value="Ezh2_CXC_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040968">
        <property type="entry name" value="EZH2_MCSS_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040595">
        <property type="entry name" value="EZH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21509">
        <property type="entry name" value="Ezh2-like__CXC_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18600">
        <property type="entry name" value="Ezh2_MCSS_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18601">
        <property type="entry name" value="EZH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="9">
        <location>
            <begin position="591"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="723"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="867"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127824" checksum="0C0FEF5187FDF871" modified="2021-02-10" version="1">MSPTGWSDMHILRDINGQLPLESDRPEFVGAAALSSRLEAFGNRRPSHRQSNFGRAAISPPPLRRLPDAAPGHSHRTQPLPTSFGRDSASSALNGVCDNPLGDDFLETALSMARHTTPPLPPPPSSHLSSEAPAINGTTPKAQTDSIADWTTPKIISQLNTCRQDVKEGHAKLTGYILESTKVTERRIRHGRDLFANVRTPVLTEKKSTTMRIKSKQHLKGKRDQREGHYTPTCTKTNKDRVPPYRFHHVEIKKNVLTPNTMLTFVPHLRDLESSEETKYNLWLKELEDIDLKSGFKPMNREDKQQLTIQGERAATVSLYLDTWLENMAIPGCDKSALISYMAAREPDYAITPQQKSDILNSHRKIENVVPGANKAAQMFTDAFHQVFKNTQPASKQIELRRVLMMDEAVDNIMDSKPIAKDATSPQLHDEDEDELAESNLATYCILGCLICFSHSCDHGEYDNKNMKRTFSISSCSHLSDALKRRRNGMERDRPSPIKPCRRQCYQRAGDHVRMHLHPRPWLEDERIVLRSIFTTASHSTYMGDPICLAAEFLNRHCDEVYTEFKSMGISLPQPEPPEAPRIKNLSWYDRRRKALLGDWQDHTTSHAHQRRENLEPCSHEGPCVPGVCTCVDANVLCEKFCGCTVENCAYKFTGCACHSQGKTCLDSKKDKPCICVQLNRECDPQLCGSCGALERADPLNADDAELHATGCQNCDLQRGVGKSLLLGRSQLDGVGYGLFTAEDIAQDEFIIEYVGELITHDEGVRREARRGDVFDEESNVSYVFTLLENEGIWVDAAIYGNLSRYINHASEHDNRGCNITPRILYVNGEYRIKFTAMRDIEAGEELFFNYGENFPNLTKKLLDHKAAGKPETKSKAAKSRRPENPETIARKATKADDTKRRPGRPRVKRDLPPGFALEAVDTDTAPGPQSRKRKRRLQDDSDEDDYDGVVSVKTANGDGGRGGRESEEPGSASRLRRRARTSTETPTKRTEPPKKTRGKRGGARPGSGRPRKHPRPVPKPAAASQSRGDDGSTVAGDAAPSPGAEDDATPASASVSVSAPVSLRHANTPEPKRITRHSEKMDMEIADSEDNMSTAALRSSGAKTTDVSAAREDDDDQDVVIRQRSDRASRTRRPPAKFRDDDIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXF7</accession>
    <name>A0A7D5UXF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">G6M90_00g058850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544459.1">
        <property type="nucleotide sequence ID" value="XM_014688973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXF7"/>
    <dbReference type="GeneID" id="26242871"/>
    <dbReference type="KEGG" id="mbrn:26242871"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI69654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="202" mass="23523" checksum="D8AFB088B4DA43C6" modified="2021-02-10" version="1">MTLYYSLVFFLLVLEMVLFMLLLIPLPHTAKRKVFTFISENPIISKVMYWLKITFVFILILFIDSVNRVYRVQLEVVAAGEQASKGAAILGHERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYVMIIDNIKLEDKVQAFESNKNYKENKSSEVAELQKRLAMKEQDLQTLKKQSEGLHRSYDELSDKYAATQVDEGKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXG7</accession>
    <name>A0A7D5UXG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin-like protein bimC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">bimC</name>
        <name evidence="18" type="ORF">G6M90_00g059890</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544558.1">
        <property type="nucleotide sequence ID" value="XM_014689072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXG7"/>
    <dbReference type="GeneID" id="26242970"/>
    <dbReference type="KEGG" id="mbrn:26242970"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="80"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI69696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128442" checksum="E680B030328A1552" modified="2021-02-10" version="1">MGASLRTAAGSRNGIPRQPAGRSSTLRQPSSLSAVRGIPDRAGAASPADSVSTTATGVKRKERDFESDAGGGGGGSEETNINVVVRCRGRSEREVKENSTVVVQADGVKGSAVGLLLGPNSLSNKSYAFDRVYSAAADQVMVFDDTVRPILDEMLAGYNCTIFAYGQTGTGKTYTMSGDMTETLGILSDQAGIIPRVLHELFNQLKVDDREHCVKCSFIELYNEELRDLLSIEESAKLKIYDDASRKGHASTIVQGMEEKHIKNASEGIKVLQDGSLKRQVAATKCNDLSSRSHTVFTITAYVKKTNNQGVDDFVSAGKLNLVDLAGSENIQRSGAENKRAAEAGLINKSLLTLGRVINALVDRNSHIPYRESKLTRLLQDSLGGRTKTCIIATISPAKANLEETISTLDYAFRAKNIKNKPQVNPMLNKRMLLNEFANEIEKLKSELISTRQRNGVYLSNDAYEDLTAQNESRRIVLEEQSAKIETLETNLRNKVHELFSIATSLMGLRKDHDGIKAQLDNTKGVLDQTEIVLSATRRSLAEETQLRKAHEKTEEKLTEIGGQLISNLHKTVNDVTGLRAKNKRKSDLQSLNRAAWSTSQSQVADVTSMVERRVLEFQEEQEEHISSVSKRMTAFVDEELRKLSTTQTLLDEHLYLFTDSKKLLLEKQQKSKGDMDEVLDEIKVVRDTVKEKVGERLQVMSQAAEKLSGDVLQEMTNFHTQLHNSYSSLGKDFKSIFEDLVKHITAQRSEADSLRRQLQSAMNTIALQNTSLSRRVQEALDEERRQTAEDRQKLMIQITSLVNSQADAQEARLADRATFIQTSVAESNASMEDAMAQYTQGMESWDGKENELMEEVKKSREQLKIKLKDDWTLASDQSTAIQNTAKSIHAETARVAEDQTDDFDTQMEALDDFVNRAKTESASHHESHGQSLQALSNTVEQSFGNISAHFKTTFERVKNLGEGMELDTNDLRDGLEPLESQVCQPLVNLREGITSTTLQEYQPTGDTPQKATYLFPTKLPRTEPHDIIISKVDEEQSSLTGDEVNDKDDTSIMFSDIGHKSSPITATRQSNVGLSDKNMSLREVNPNVTANLTTGALAFDPRASTMSMPPEHTMPSFKKPLKGVRSVRNQPVLAEGRENLLVGFEQSLSRRKSPRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXT4</accession>
    <name>A0A7D5UXT4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Highly reducing polyketide synthase alnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alnA_2</name>
        <name evidence="10" type="ORF">G6M90_00g060030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986804.1">
        <property type="nucleotide sequence ID" value="XM_066130690.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26242984"/>
    <dbReference type="KEGG" id="mbrn:26242984"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="2"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="939"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2297"/>
            <end position="2371"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="939"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="971"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2376" mass="260366" checksum="EA14DA5333B4CD9A" modified="2021-02-10" version="1">MDDDIAVIGLGLRFPGDATDPESLWKILEAGESQWSEIPKERLNIDGYYHPSGDRQGSISFKGAHLLKGDIRAFDATFFSIPSEDAKAIDPQQRMLLEVSYEALENAGLKKEDVYGSDTSVYVGSFVKDYEQVCLRDPDWSPQYAATGNGIAIMANRISYFFNFHGPSVTVDTGCSGSLVSVHLGAQSLRNRESSIAIAAGAGMILTPSTIMPMTALNFLSPDGKCFTFDERANGYGRGEGIGVVIMKRLSDALRDNDTIRAVIRGTSVNQDGRTTGITLPSKEAQVANIRSVYKSAGLDFDQTAYVECHGTGTQAGDWRELKAVSETLAADRDIRKPIVVGSVKPNIGHLEGAAGVAGIIKGVMVLEKGKIPPNINFKTGNPDINFENWKVPTSLMDWPMPGLRRVSINCFGFGGTNAHAILDEAPKYLQSRGLIGNHSSADMTPSSPDKLMLDEDATKSRENEYQLFCYSAHEKSGVSRIMGSHSEYIKARAKSGPRELLTDYSYTLSCRRSTMEWKGFIVAKSITELAAKLETAGSSETVRSLRKSQPRIGFVFSGQGTQWARMGQDLMQFQVFRSSLEEASEYLLHCLQSPFNLIREILRDESDSAISYPHIAQPATTAIQVALVDLLHAFGVSPTSVIGHSSGEIAAAYAGGAVSRFHAWEIAYFRGLAAISMPFRAPKLKGAMLVLGMSFDETRKYLEDGHFSAEIACVNSPASTTISGRVDAIEAISQDLAERKQKVFCRTLKVQTAYHSSHMRLVEHDYRDSLVSIQPRELQTQVQMFSSVTGKSVRGEELGPHYWSDNMVNPVLFVAAVTSMMQQPVEARPEILIEVGPRAALRSPTTETMASIFHEDLIPAYYSIMQPKINGILKVLGLVGDLWTEGCSLNMEQVISRGEIQRMKCLSNLPPYPWNHDKSYWHESHLSIANRNREYPRQDLIGALTADSTPFEPRWRGFLRVSENPWIQDHQVQKTIVYPAAGMVSMVLEGAKQIKPAMDGFLGYEISHMHLSKAMIVPNTEHGLEVALNIKITTDISGEVQPKASHQFSIYSKYLGRDWEQHATGFIQFKHTTAYSSAPSTAHDKQLDKLSDSCKKGMNSRQLYEDLDTIGMNYGPTFQNISNIRKGEGACVCKVGVPDTKSKMPAKFEYPHIIHPATLDSMFHPLFVIETVPMVPTFIKSLFVSTGIDQDGPKVFSGFATADRVGLQGATAKIVMNGCGTSKTRVIVNGLYLTALQSTGLEEKFLPSFRNLCTEIVWREDATFDSSTDLIENIRVLAHKYPGLAVLQAGGSTEDATELLKVLAPAKDDAPSLSKFTLLGHKDSDTFHEVINKVKETPAECFVECKTNMADVNSNYHLIISFDDLGLELKKLKDKLQVGGVLMKLKSSSLNHYTPINGNIDEQHSRNPVVYRRPAALLGSPAPPIILLVPEDVNDEVSALVDLVKSYQTKPAQEYEISVLNTQEILKCASLVEKSVIISLLDVFPSHDQHYSILQWDEFHFNLLKDIQKAAKGMIWLTRGSHMNPHNLQGSSIIGLARTLMSEDPRKAIVTFDLDVATNICDNTVVKNIMAVFSQTFCEEPRPGCYEMEFAEKDGKVFIPRLRTIQALNQIIEGMAPCILNNRPFHNDAAGPEDLLDVKLSLVKAGLCDDSWHYTEFPQTDILPDEVDIKFSQTLLIPQDVETALGRNFESSIGLDVRGTIISVGRNVTEFLPGDEVAGLVSDGSIQSTLRVKLPFIQRNSTSLFPSQLISAYYSLVYMGRGKPGKSVLIHAGASAYGLAAIALARILGVKLFATIVGQDPDNQRKILESCGLTSDTIFSAEDEFTPCLLTMTDGKGVDILYSTSQDRLNGVEKCVKDCKPISPRPSLFRIFGSDLLGGLIVRLVGGSPYSIGRNFESMSRATAVNFDLRRLLREDADFVTELLASASKFLDEKQFDDSVVTSSAKDFSIDSLDKALKHVQEHPYQGVCTVSANSGENHKVNVLCDNNFKSLSEAIDPEGTYLLAGGLGGLGRSIAELLIANGAKHLAFVSRSGISNSQSRDFIEGLQNEGVDARVYQADLCDKASLSAVMKNQLFVQMPPIRGIFQCAAVIQDSVFDNMTYQMWNAAFLPKTQGSWNLVKNMAGLDSKPFFVFLASSAGIIGNRGQANYAAGNSFIDALAHHCLLHGVPAVSIDLGPVLGAGMLAEDDDMLDKLRAAGFYGIRHDDFLTVIKHAITREIGSLGDTTPAQVILGVGTGGLLRQNKPADPYWSRTALYSYLNLIDMPPPGLDGSNGLQGMDMKSLLARCGSTEGAVDLIRLGLSNMLAKATNLLPEEVDVNKPPSAYGVDSLVAVGVRNWVLSNCNVEVSVFEVLSNDTIMEMAHMIAKRGGYEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ31</accession>
    <name>A0A7D5UZ31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein mL38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g065400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540234.1">
        <property type="nucleotide sequence ID" value="XM_014684748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ31"/>
    <dbReference type="GeneID" id="26247043"/>
    <dbReference type="KEGG" id="mbrn:26247043"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000004">
        <property type="entry name" value="Mitochondrial large ribosomal subunit YmL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="443" mass="49905" checksum="47025A15BA013218" modified="2021-02-10" version="1">MSRCQAVARPLARQLRQSCAVRPFTTAAPRAAEVQEQAAAASREPSALDLDPTTVLPEFEAELIKAGKMPIGSRRRRMAMRTTQNIPFEQLPYQAFQEARKILAADREDKLAKIKAELDKISKLEAKDAADVKGGQKMKDVKLASLRREVERLKLLADANDPLVKKRFEDGLGDMNKPIYRALAEKKWRSYDYRLITQRIKQFNIVPDVLPKLEPTADVQLYFRQSKIAPGDIVNSQVSENAPRLRVQVFNKGERLVTVVVVDSDVPDIEGDSFTKRCHYLAANIPLSPTDTSLPLGKIVAEDQLAVPWMPAFSQKGAPYHRLGIYLLEQRAGDKVDVAALKELYAARGGFSLKSMRDKFGLAPFGFSLFRSVWDENTAAVMARHGISGADVELRPTRVHSLKPPVKPRGWEAKRQGPKYRHLWKYTKRIKGISNAKGWIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZJ2</accession>
    <name>A0A7D5UZJ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g069040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539990.1">
        <property type="nucleotide sequence ID" value="XM_014684504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZJ2"/>
    <dbReference type="GeneID" id="26247210"/>
    <dbReference type="KEGG" id="mbrn:26247210"/>
    <dbReference type="OrthoDB" id="4939983at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028995296" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="105" mass="11396" checksum="CE77AAFCFB266DF9" modified="2021-02-10" version="1">MKLTAVLVAICAAAASAAVAPVRSTPLNPHTSHPFDRYPGCSVDCLKSSFDEAGCAYSDSKCGCIHKRVITKRSKPCLWARCTMDECIKIKNMAMETCDRIEKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZN6</accession>
    <name>A0A7D5UZN6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secondary metabolism regulator laeA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">laeA_4</name>
        <name evidence="3" type="ORF">G6M90_00g074190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545647.1">
        <property type="nucleotide sequence ID" value="XM_014690161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZN6"/>
    <dbReference type="GeneID" id="26241680"/>
    <dbReference type="KEGG" id="mbrn:26241680"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="313" mass="35086" checksum="EC443675502A9130" modified="2021-02-10" version="1">MNDDDSTFGEAPSNASTSIRSSVTRYEWKHGRRYHAYQSGTYPFPNDEREQDRLDMLHHATTRLLDDRLFLAPIQPDGMRILDIGTGTGLWPIQMGDLYPGASITGNDLSPIQPTWVPTNVNFLVDDVELDWIETNTYDYIHCRYMSASIKDWPRLIRQIHDALKPGGWVEFQEFSTTFSSDDGSMGVDHPTHAFVQLSLTLKEACSKTGRMLDPTPCLKRWSSEGGFNTIEQHVFKAPIGNWPKGLRSKEVGTMMGVGLSDGVDGMTAVLVRDVLGWSADEVEVLNAKVRSATRSDPKVMVDYVVVLAQKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZT0</accession>
    <name>A0A7D5UZT0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low-affinity iron/zinc ion transport protein fet4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fet4</name>
        <name evidence="2" type="ORF">G6M90_00g069680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540706.1">
        <property type="nucleotide sequence ID" value="XM_014685220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZT0"/>
    <dbReference type="GeneID" id="26246579"/>
    <dbReference type="KEGG" id="mbrn:26246579"/>
    <dbReference type="OrthoDB" id="2224262at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="515" mass="56957" checksum="0BCB9648131E9A5C" modified="2021-02-10" version="1">MLNQLINWLSAPGIKGAIEERAPTQHVALKSSIADGKDSIAVVSDAKASDSQSVNITGYVAQTKTGRLDRWLDALVTASGSEPVFLIIVAGLLVWAFTGIRYGEQDNWAALISDIQAIVSYLFDSLLMRQQLNGYERQVRAAAGLRSRTQSQKRMMRRVLASGRCKRARVQDVQAAESSRFGPELPAENWAGRASNCFAAFLGHFATICMYWACIGVWLAFGHYCGWSDRWQLYINSATSALMVLIFAFLANIRERHTVYIERCLDAIFEVDSEVELKLRGLTGDAEENPVVVIPAPRVNGIQRAIFYYADVIGTLVGIALLVVVMVVWICIGPAMRWDDNWWLLIGTYAGLVGLVDGFVLRNVQQRLHQYEEAALESAKLEDVAMADEMGVPPPDRAVVNLGSVNYRLSNAMGVICAHELTVILGVVVVVGLIVGASAMKWTTTGQLLCNIPPSIVETFFMMILITGHNLSEAAWRADLHNMYLWRLRMLSFVDHLEKSEEAATEKTPDTVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZY1</accession>
    <name>A0A7D5UZY1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g079820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539953.1">
        <property type="nucleotide sequence ID" value="XM_014684467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZY1"/>
    <dbReference type="GeneID" id="26247291"/>
    <dbReference type="KEGG" id="mbrn:26247291"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="56"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="415" mass="46957" checksum="DBEA42E3AC61ECBA" modified="2021-02-10" version="1">MKLSYNPSHLPLRRQASDVPASPPTTRPTPPGISYELFIGFLWAGVAIATIFIASRLYARIRTSRRLYLDDLFISFAYVLVVVTAALWQWGAKDMYYILNANAGLVQVGPDFVTRMRRFLLVSFIVEMFFYTVLMLFKLSLLFFFKRLGSSVDRFKYFWWPTLVFSMCTYLVAVGDIDYECLFGSLKDITVRCNSPSGTYFLKVTLDVNCALDVLSDFLIMLLPILLLWNVQIRLGKKIALLGLFSLSIITMAVAIARAADIGATQKSNGLPDSTYLWFWSSLQSFLCIVVSCAAAFRQLFVSSTRSNSTPLRKPTRSCYERMASNFRPRRRKPNDTILYDMPSTRQTGKGFNAFDCVAMRDGSEADSQHSSQSPVLVPRLGKPVAACYKAPDQNHTQPNHITREVEFRVTQHTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0N9</accession>
    <name>A0A7D5V0N9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor 38B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686339.1"/>
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    <dbReference type="GeneID" id="26245293"/>
    <dbReference type="KEGG" id="mbrn:26245293"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40132:SF1">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="87"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="45497" checksum="C6BFE240CAF59985" modified="2021-02-10" version="1">MSNDEFLTDEYVAGLLAQDAKDCSLKYSAMGMEAFRDNKKPSTMPKPNTRFLRHIIKDTDTHNKALLAKEAAESKARLQDLEHAEEIKRRKTNPNAKDIRRRQMGDIQAILGGRNRRRGNDDDSGTSTRCDKDDGKDRHERKSAKRSDDLCRREYEKRRYGRLSERDYADDDAESGSDDRKRSRRSRHHASSDQDESRHRHGRSRRDGRSKSPRRHRSSCSPDNRKRSHRQRSRHRSKPRDSSRSRSKKKPSPPPAPDEDSDPLEDLIGPAPPPKFRGRGTIGGAAELDRRFSESYDPRLDVQMDEDEEDVWGDALESFRDRQKLRLHQHQRMKDAGFTEQEIQRAEGTADKAGEHVVWSKAGERREWDKGKGLGLDGVDEDDKNPPTLFSEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Q7</accession>
    <name>A0A7D5V0Q7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidase B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g092680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C69 family. Secernin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541912.1">
        <property type="nucleotide sequence ID" value="XM_014686426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Q7"/>
    <dbReference type="GeneID" id="26245380"/>
    <dbReference type="KEGG" id="mbrn:26245380"/>
    <dbReference type="OrthoDB" id="5175656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994:SF17">
        <property type="entry name" value="LD30995P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="SECERNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028811570" description="Dipeptidase B" evidence="2">
        <location>
            <begin position="17"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="57110" checksum="B5ADEB74F0EB72FF" modified="2021-02-10" version="1">MKPLVGLAVLVPQTLASYAFYVGKNLTRDGSVLVGGTGEEVSSHWLQLFPAADHAPNETVTVGVTGGANIPGELMRIPQVKHTFRYLSMEYSDYMGFPAPLTNGGLNEKGVAVRDVWATNRAELIRMTPTPQRGVQYSDMARLVMERASTAREGVELIRDLIRDHGEATYGGNTHLIADKDEGWVVWELAGGRGLWAAERLGASQVRALYPGYIGDFPVDFANSSDFMGSDNIVTFAVEQGWWRPGSGEPFNIFKVYGPQGPGYTERDGGFKYMSQAALENATLAMAPVSEAGLMERVRDHRIADDEAGYGQVVSLREGVDPDMLRVWIAPTGSVASPFIPWWLGGQSVPPEFGQHRYLTTGASSSFLAPDFQLQEASRFAGRIFKRVLYYMCSAPALFFPIVTDALTAFESESARDLEWVERSAETLIASGERDSARRLMTYYSHSRAAKALDMGNTMNDALDMYIKLRGLWRDPVGKDINDAGEGAETVNCLVGFNPDRPANQQVVPGSGRFVVQDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0S9</accession>
    <name>A0A7D5V0S9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g090650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541723.1">
        <property type="nucleotide sequence ID" value="XM_014686237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0S9"/>
    <dbReference type="GeneID" id="26245586"/>
    <dbReference type="KEGG" id="mbrn:26245586"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="424"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="612" mass="66478" checksum="720DA859124A6293" modified="2021-02-10" version="1">MAAATEPALRAYKRDMSDGAIAGTVVGVVVAVALLAFCLYPVVIHQIKRRRRAQRPKFDAEAGLFPQPGTGPVQHQNLHRRLSSTDSFKQNGDVARGDFGALQNKEFGWPSYNGHVTQPDGNFGPSRQFSAQTGDGSRQEQSHYTGNNFSNDEPFPYYFENTPAATAHDDNPGVLKGTSADYYSPSIPSSAFGMITTPEPADEPPPTLSRGSSLKHHIKHMFRQQSGRENSLASVLSSNDKATASQVPPGTELGQILTTGRATDSPTELSPTKTSMPPPYVPGVTEPPETKESSASPPQLTIQTPPQSPPPPAERAFQASPSPPTFPAPGTVNPMDIMPASTESEVWHRTEHRLHTSYGSSPGLSSTGDPAEQEHFSTLAFTPLPTSALSPSDAANAARPATPTNQNAVQGLQAMDENDVPMVDVHSHDHLSPSMIPDNGRHQSCTSDGSTQYHGPHSTGPSTENTPSTQFDSPSPGSMNSSEIRNSASPQPGQASPRTGLFRCDEPGCSQVFDQPHKLKHHQRYHIKEHKCPYKNCGKGFGTKTHLQRHINDRHEKKKKFHCAFPECDYSKAGGKAFPRKDNWKRHMTKIHNMDQQHLPEPIEVDLDMGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Y6</accession>
    <name>A0A7D5V0Y6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g075240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987095.1">
        <property type="nucleotide sequence ID" value="XM_066131041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Y6"/>
    <dbReference type="GeneID" id="90967979"/>
    <dbReference type="KEGG" id="mbrn:90967979"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="58" mass="6414" checksum="0F1D28AE3E852797" modified="2021-02-10" version="1">MTQLCKGGNAMLLAYDTLAALKHLNYYPSATMWTSHFIRVYGALDRGLCQGSFVVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1B1</accession>
    <name>A0A7D5V1B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mnl1</name>
        <name evidence="10" type="ORF">G6M90_00g092220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541866.1">
        <property type="nucleotide sequence ID" value="XM_014686380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1B1"/>
    <dbReference type="GeneID" id="26245334"/>
    <dbReference type="KEGG" id="mbrn:26245334"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028905736" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1056" mass="117516" checksum="AF63626395E02746" modified="2021-02-10" version="1">MFVAATLLVSALLPWITTSMRADYLAQLRQDTVDMFYHGFSNYMKHAFPEDELRPLTCGALTRDRDDPTRIELNDALGNYSLTLIDSLSTLAILAGGPQDGSYTGPQALSDFQDGVAQFVRLYGDGRRGPSGVGARARGFDLDSKVQVFETVIRGLGGLLSAHLFAIGELPITGYDPKPAETLAEKDPLELAPIPWPNGLKYDGQLLRLALDLAERLLPAFYTKTGIPYPRVNLRTGIPFYVHSPLNGDADRSKDEEGRLETTETCSAGAGSLTLEFTVLSRLTGDPRFENVAKRAFWEVWRRRSEIGLIGNGIDAERGFWIGPHSGIGAGMDSFFEYAFKSHVLLSGQEMPNVTRSRRQSTTNWLDPNSLHEPLPHEMHSSDAFLQAWHEAHASVKRHIYTDRNQFPYYSNSHRATGQPYTMWIDSLGAFYPGLLALAGEVDEAIEANLVYTALWTRYSALPERWSIRENNVEPGIGWWPGRPEFIESTYHIYRATKDPWYLHVGEMVLKDIRRRCYAPCGWAGLQDVRTGEKQNRMESFFLGETTKYMYLLFDPNHPLNNLDAAYVFTTEGHPLVIPRGKNSKPVRRKRQSSNLKDVSVSSYYNEKFTNTCPAPPPLQDPLTGSSTAARPDLFGVSRFTNLYNTPNLQGPVEEVLVHDEKKGLITKYRATSNHTIFPWTLPPTMLPANGTCVAPPQRVISAIEFPTTDAASSLISRLGAHIAWYSYLGPTATNLEGLRLQLEQEFSDDRGENVWRITHVGNTQLGRHETVFFHGEHVRHLKDEAFTCLRHKDSVNIQVLVEAPRPSNFTTPPTSENTSPPSSSSAILSSNIDTDLDAADLGVIPSESLFKHLLRAVTSVFDPSETDAPESETRDSVSASFHTWQAFTSVGAGSYPVPSILDSPIPGSPTYNSHDPMANFPWKAIYIADEACSGPLPDSAPRDHQVIVIRRGGCSFSDKVANIPAFAPRRSSLQLVIVVDEADEHGQHRDELPRPLMEVEQLTPKGMKRLHGVPLVLMRVARGEYDLFHSALAVGMRRKYTIVSQGLIIDNAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1J8</accession>
    <name>A0A7D5V1J8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CDC25_1</name>
        <name evidence="16" type="ORF">G6M90_00g088270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542288.1">
        <property type="nucleotide sequence ID" value="XM_014686802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1J8"/>
    <dbReference type="GeneID" id="26244802"/>
    <dbReference type="KEGG" id="mbrn:26244802"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="16" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="733"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="902"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="624"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI72314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1182" mass="131375" checksum="88D7C34CB290D222" modified="2021-02-10" version="1">MDGIVGTAPPGTMYVRALYDYEADDRTSLSFHEGDVIQVITQLESGWWDGVINGVRGWFPSNYCQIVASPEDLPEHGHNGPTDQVVDEPDEPEGFDESFDQDDDSEAEDPAGLPLEGTDAGDKSRADFWIPQATPDGRLFYYNMMTGDRSMELPLESPLSSTETGPRDRANVNIPDKTRPPPEMMARGLTQDEDDDSATSASEAEGESLMFASRGYMGRDRASTSGVLSPSTSMDSINGASPNRRKRSDGQPNGKQGSLQPPNMASATSFTSTTYNLPTTATVPRSFFDDGSTPPLTWSLLVSNMKRAIDRYREAITKNCRSEYVARAEDISDHLRLLLAAGSGTTDNHSGQPSIISTNKALYPHFRDMMSKFSKLVISSHIAAADWPNAESVQKCLQEADGVLLGVFSYVEVARQQRGEEIPRLFPGFVIGSTVGGSWQNNGLGPRDPITANFLEDEEGLVEPSAILNGRLLERLDEQKRILVSSIRELDKSLITPEKIVTSLRHEAVGNNVCSAGGKVVETFKMWIAMIESIDLSSLGSSFQTPQLGDFGINKQSLYDNISDLILGCQAVAGPLADEWNEVRGESLENRLEYVRQCARALETNSSHIGFSLQLLSEQVQVNPQLPQHTESRTREDSVSRATLQRGETLPYERSHQRSESRSAPGRPSLLPGQSFGEGDPPAGNFRKGDYSKVKKIFGEDPSPQTGMQASDDTPDFLRLDYENDVSWDTKSASPTVKGGSLLALVEQLTRHDKLDSSFNNTFLLTYRSFTSARELFELLVKRFGIQPPDGLSQSDFESWRDRKQKLIRFRVVNILKSWFDSFWMEEQNDESRQLIRDVYTFARDTVKSTETPGSGPLMAVLDQRLSGKEAGARRMIQTLNQSTPTPIVPKNMKKLKFLDIDVTEFARQLTIIESRLYGKIKAAECLNKTWQKKVAEGEPDLAPNVKALILHSNQMTNWVAEMILAQMDVKKRVVVIKHFVAVADKCRSLNNFSTLTSIISALGTAPIARLKRTWDQVPQKTQGVLETMRRVMASTKNFGEYREALHAANPPCIPFFGVYLTDLTFIEDGIPSIIKKTNLINFAKRAKTAEVIRDIQQYQNVGYSLQPVPELQDYILSNMQAAGDVHEMYDKSLHVEPREREDEKIVRYVRRTAGVAAMVSGMEMLSGAAFEKMSSSVSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1U5</accession>
    <name>A0A7D5V1U5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial nicotinamide adenine dinucleotide transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">YIA6</name>
        <name evidence="12" type="ORF">G6M90_00g077800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545325.1">
        <property type="nucleotide sequence ID" value="XM_014689839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1U5"/>
    <dbReference type="GeneID" id="26241358"/>
    <dbReference type="KEGG" id="mbrn:26241358"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="122"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="246"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="376" mass="41756" checksum="C4BF296EAEC4C6D0" modified="2021-02-10" version="1">MHHAGPTPFQKWAASASDSQFNAVAGAVGGFASGVITCPLDVIKTKLQAQGMYRVLQDGRHVGQPRMYNGLSGTANVIWREEGIRGMYRGLGPIVMGYLPTWAVWFTVYNKSKVWMAQYSDSTHLINFWSSIIAGASSTIVTNPIWVIKTRLMSQSHSPARDHAHYMFPKPGNTPTARPTLNHPWHYRSTLDAARKMYTSEGLVSFYSGLTPALLGLTHVAVQFPTYEYLKTQFTGQGMGEGAGEAHWFGILSASVLSKILASSATYPHEVIRTRLQTQRRPVAGEQFLQGLGIAAPDPAKDPTVDGRKYRGIVTTFRTILREEGWRAFYAGLGTNMMRAVPAATVTMLTYEYVMRFLHRAKEEGRAKMHMHKSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2A9</accession>
    <name>A0A7D5V2A9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g094410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540805.1">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
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    </dbReference>
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        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
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    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
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            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
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            <end position="348"/>
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    </feature>
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            <end position="381"/>
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            <begin position="402"/>
            <end position="423"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="429"/>
            <end position="454"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
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            <begin position="496"/>
            <end position="515"/>
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        <location>
            <begin position="49"/>
            <end position="520"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="542" mass="59645" checksum="7EC76698E69A7B73" modified="2021-02-10" version="1">MEHRTDETDVPGTVSLEDLNNVSDKVVLHPVPTTDPNDPLNWSSLRKTVNYGLVQIYVLFTFVQLDIGFTAWNQYQEELGLSVGTLNGATALNYAGLAVGSFIFIPLMHKYGRRPLYIVSTMLQLASCVWFARANTQADMWLANLVSGLGGAVCETVVQVTICDIFFIHQHAVMNAVYLLFTSVGAFLGPVAAGYIVDSQGWRWMWWWCVIFFGVNLLLVVFFFEESKYVGAIQGQPVADTASIQDAVKTDMDSRHVEEKAYKSDFRISEDDVQRTESRSYIDGGIPMKSYRERMRLVTRTDESILRHMHEPFPVLFTFPAVAFTAITYGSMLAVFAILVSVQAIYLFSPPYNFSAAGVGLMNIAPFVGTIPGVFIGGTLNDKSILWLSRRNGGVYEPEMRLWLALPCAIAGPAGVLLLGVGLANGVAWPLLAVGFGLFGFTLTVAGSIALSYAMDCYHDIVGSSMIGIIFTRNVLSVVVLFALTPWIESMGLQNVHILVAGILGLILLIPVLLLKWGKKARARSAKAYRAMAARQSTSREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Y7</accession>
    <name>A0A7D5V2Y7_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g101800</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_014690679.2"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
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            <begin position="248"/>
            <end position="280"/>
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    </feature>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI73490.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="769" mass="84995" checksum="BF5906D0DCEECACB" modified="2021-02-10" version="1">MTDSTFPRPCKGKKIKCGEEHPYCKNCLKVGDVCDYSVRLNWSGRHTKSQFVGENSCGNPWPEGKLDQVPHELSAENPELPDHFMISGQELDGADSYSEDRIQQPLVPTTVFKNMTTTNDAGKQENSFNNTLIFIDESQQHLSGAGPSESYIAKRHLGHSQGTTSVSSPYRGSLVNSPAVGAAVHKKTKSFTEFTELDIGQSQLMPCPSYTQKSTSATWPSYPNVLDSPLTPTLSSYSDDITSRSNWTELPSLGSPDSWGSGKGFSENSPPQSGHLSEEPGAYGLQETLSSSDVYPCGNGAFYGYDSGAADEDLLKNDDAITVVLLPSTAYNSASGVVDFGEEAMPWQIRDRMSGLNQYYYKNVVPVVIPWALEPLPDMLKRNKMNLLYFHHFLNHTSHVLVPYHDDNTNPLRTQLVVMAVKSEPLMSLILAYSAAHRSQLLETGLPQMRMAEWAQSVFPALRESLLGASSPMPNVTLAMAVMLIALEIMSPGAFGRGVSWREHVAHARGLLAKCLDHGPQDTTVEGMWFIQSWLGYIDVMGGLMAGPLLDMTCKSQVYFPPPETRRCANDLDEIDCMMGISVKCARLLGQVAELAKQCQGERFRLDGQLLQGWCPQPTMVEQALLLEKHLMESLRQSSRPCPHVRAGSIHMRDLAEMAGVNEAFHWAGMIHLHRRVLGKATDHPDVQGSVRRIMQCLEQIGTRGVAKTRYLFPIFTAGCEALTERQQTKLLGRLTNAEKSGMKQVREIFFGVLFRGVEDVIDQEGVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3K5</accession>
    <name>A0A7D5V3K5_9HYPO</name>
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        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g089160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541580.2">
        <property type="nucleotide sequence ID" value="XM_014686094.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3K5"/>
    <dbReference type="GeneID" id="26245443"/>
    <dbReference type="KEGG" id="mbrn:26245443"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="12"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="26"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51171" checksum="53FA20BF882786B8" modified="2021-02-10" version="1">MIGMNESQLRAISAIERACSVLSLLGCLFTIVTFCYSRSFHKPINRLVFYASFGNMLTNIGTLMSRTFLENGTSFGCQFQAFLIQLFMPADAFWTLAMAINVYLTFYFKFDAERLRRMEMAYLIGCYGIPFVPAFVFLFIKDHDGARVYGNASLWCWISYDWDLLRIAAFYGPVWIVILMTFFIYIRAGRTIYEKHKQLRGFNSSDPDPLSVNGDAPISTVKTTEITVTSEVAGERGMQLASMNRQNSNSVPSTKSPNGAYTVHISADLNNTAQAYDEDALPIQGTTLQHTSTVQLAPRRPANISRRRNHELNNAAWSYTKCSILFFTAILITWIPSSANRVYSFVNDKDVSVTLEFMSAFVLPLQGFWNAVIYAVTSWSACQELLEDLRWKKRSHVSELIDERNGRDKKDAATPPRSRNVLRSPPGSSRTFASDSTTELAKARAHSADGSRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3S0</accession>
    <name>A0A7D5V3S0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g110920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543768.1">
        <property type="nucleotide sequence ID" value="XM_014688282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3S0"/>
    <dbReference type="GeneID" id="26243155"/>
    <dbReference type="KEGG" id="mbrn:26243155"/>
    <dbReference type="OrthoDB" id="409121at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000038">
        <property type="entry name" value="Cyanamide hydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017771">
        <property type="entry name" value="Cyanamide_hydratase_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03401">
        <property type="entry name" value="cyanamide_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF8">
        <property type="entry name" value="HYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="63"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="244" mass="27221" checksum="53D43FD04B824F2A" modified="2021-02-10" version="1">MAPDEVLLHGWTAVPVDAGQLFDGKTYKNTPTPLKVDCIEFPSDDPIVVKAQGYAKDKLPPETFNHSMRVYYYATAIIRQQFPEHVKSFSPSTLALTALLHDIGTAEENMSATRMSFEFYGGFKARGVLQDFGSTQDQADAVCEAIIRHQDLGTDGNITFLGQVIQLATIYDNVSDHPHLPDIKELVHAVTREEVIDAFPRKGWLGCFAKTVQKEVGLKPWSHTTHIPDFDDKILGNALMKPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V409</accession>
    <name>A0A7D5V409_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g088130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542302.1">
        <property type="nucleotide sequence ID" value="XM_014686816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V409"/>
    <dbReference type="GeneID" id="26244816"/>
    <dbReference type="KEGG" id="mbrn:26244816"/>
    <dbReference type="OrthoDB" id="5419752at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039914">
        <property type="entry name" value="SRP9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12834:SF12">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="162" mass="17002" checksum="6984657CEEA1E73E" modified="2021-02-10" version="1">MPYFKSSQEWLEQSTLLLEARPSTTRITTKYSIQPVKSRKRKADDADGDTPVNDAPNPPRGSLVIKTYDPVSGVTLKYRTTKAAEVSRLVYSSLGRLGRAMAAVPLDVPEEAMPDASGGGGGGADGGDGDNKGSGAATPASQQPQGQQAQQGGGKKKKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V439</accession>
    <name>A0A7D5V439_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g112290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540296.1">
        <property type="nucleotide sequence ID" value="XM_014684810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V439"/>
    <dbReference type="GeneID" id="26246890"/>
    <dbReference type="KEGG" id="mbrn:26246890"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="165"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="513" mass="57481" checksum="E6DB6E02DC135030" modified="2021-02-10" version="1">MSATTTDPLVAPTAETDRSKSLTAAQIAQEKEESRRAAAQARGIASKAARDSDGTTIAPVKSIWPPPYYFEDDLRRVRPYHWTYNTFCKERWRGRSLIEIFESEFRDRPAEYYRTSMEKGDIFVNGTKVGPDYILRNGDLISHTLHRHEPPVTSDPVGIIHEDDDMIVINKPSGVPVHPAGRYKFNSVLEIMKAERGQEFMPYPCNRLDRLTSGIMFVAKSVKAAEALGNQIKSRTVRKEYMARVVGEFPEGEIVCDQPILSISPKLGLNRVRAEGKAARTVFKRLAYYPPRGDAEANGQQGGVPEPTDKELSRLPAEEGDESNGKPWVNKRGYSIVRCLPVTGRTHQIRVHLQYLGHPIQNDPIYANQRVWGFNLGRNDADGTVSTDEDVISRLSRMGKEEVAQAVVYHDEMLDKYEKKRAEKMTGEVCDVCATPLYSDPGMHELSLWLHSLRYEDAGGAWSYKSPLPKWALPPEGMAGPTTVGGMDELVEAVKDDNPEIHGIPGAEMERNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4F0</accession>
    <name>A0A7D5V4F0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MutS 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MSH5</name>
        <name evidence="7" type="ORF">G6M90_00g109980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI74630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4F0"/>
    <dbReference type="GeneID" id="26243245"/>
    <dbReference type="KEGG" id="mbrn:26243245"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="681" mass="75116" checksum="E0C2A1762BB081AF" modified="2021-02-10" version="1">MALDVCDDGTMGCAFFDSMDGSLQLAEDVHRSTVDVSEHFATLACPTLLLVSSRAPQEFLDHVQRSAFPYKSCVQILSSSEFSVEAAVDRLSSWRNDQLSTAQPSSRAPVDASVRRDLPNGGDGKRVDRCSISPEEGVANASTREHKNPVSLGCAGAVLTELRYKCISRSSPSSEPISHQPIPTIPKFDQDSLVAIGELISHTVDFEQSEYRGRTTVRLGLDRNLDELRRHYDGMNSFLAEIVVSTIQTVPQWAVSYIRSCIFLPQLGFLIVTDVDPRTGKGKYRVNWPNEDHWELLFVADDSAYYKNDNMHHLDDQFGDVYCKIADREVEILHVLSQEVLKSSECLSVASDACGDVNVILALALTAEKYKWSVPKLTTRSGILEIKKGRHPLQELVVPSFVPNDCQLGGRGHNDDDSCQNQSRCMVLTGPNHSGKSVFLKQVGLIVYLAHIGSFVPAEMAVISVTDRILTRISTLESVCKEESAFAIDLKQLLNVIELSTSKSLLIIDEFGKGTNSDDGAGLLASFLEHLSSLAVRAPRSLVATHIHDLFGCHQLLPTSGLQIAHMDVLKAQCGEFNGDYITYLFKLRDGYSSDLFGGYCATLNGVPNLVVERANVLSMLLSRNEDITVPCARLSPEEELKLHSAEIVARKFLEGFHTLVSEENCLLQDARHMLQNILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4W3</accession>
    <name>A0A7D5V4W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g100500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987713.1">
        <property type="nucleotide sequence ID" value="XM_066131576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4W3"/>
    <dbReference type="GeneID" id="26240721"/>
    <dbReference type="KEGG" id="mbrn:26240721"/>
    <dbReference type="OrthoDB" id="5380370at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="727" mass="80716" checksum="0DD254B64D359374" modified="2021-02-10" version="1">MAQVDNSRAWEADDNGSLHLAYPISPVYYQEMKSFLDLDSPTKSSFSLSTGEHDHADYYHSSFLLLDSVPAAVAIMAANAPSTIEKLESIASTCSARDNGHQARLGSSNSLATFPMSIRTETSCTSSNSSTRSRNRQYILPNAGGPFRRRRVRDSFTDGGDDTEHSHMGNTQHHCYSSIRLMNNEVVKKAVPPPPKPQSRSSNQRCNPMQTFKPLRSSCHGRASSSDGLPRSPALTRDEFEALPPTIQRKYFSTLERLRITQGQDYQEIDNSGQESSDSLSFALSCDEEDRPPLRLGFGQDELENAPHRRPQGNALRIYASPGNRLSRNRYASCDQLRGQSSGQSIISVATEESILRMGKRQLRFESLPRSSTSPKPNPGSMVSLSANATTAAPDLKSTADSMYESFRWLEEEEDLDLKLCLDDHHFNLRGEDVLAEKHRPSFRRHMSISKLPFSSRASSTLSRPTTKDTSASPPLMGSPVSSPSSPILGHVRRRSRALSLISPNKQPVPDASVSIDAAAAHYQDPDARMKLRVYLASPHKFDEAVEFGFPSIEEVQSSENYPRRKRASLSQGQSTNSMAKSNGSPEDDKSSVYSDGASTKEPESPRTPEMEKSLSVKPVRVSQEKDDISNTAGYAQAPAACREMTLRMTLTRPDLRANEDQIYGWQKTSNGRKSQARDEPLSPVSTTREGHSKESIERQLATMDQEDLLANDNGVMKRFWNRVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5W3</accession>
    <name>A0A7D5V5W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g106410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539858.1">
        <property type="nucleotide sequence ID" value="XM_014684372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5W3"/>
    <dbReference type="GeneID" id="26247297"/>
    <dbReference type="KEGG" id="mbrn:26247297"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45986" checksum="806A8FA81E533C26" modified="2021-02-10" version="1">MSQPPEPQAVAKELLSWIGFELISCNTLQTLWAGYGHICAIRCRPLPSAAPAETTRATHSLILKLVSPPRGRKDEGHLRKVLSYQVEQHFYDHVAPTLRGLPLAECLVSTSKFPHKAAAAGLQHVTASVLTDLRLDYPVAGEKRTALSPRQVHAALGWLSRFHGSYWTSPRPDAQSLILPPLEEDKARQQQPGNSSARRGLWLNGGYTYLATRRSEYNALAQDGGSEWSQTFCQAVEGTSMSVAELAAFFLTPTGRDFETYLHGDVKSENLFSTESGDEVAFFDFQYTGLGLGVCDLAKLFTCSVPVEMLTASTGEPRRLTMGAGERHLLLQYRRELLQGGGVIHAPVYDWIEFQRHWETALVDWCRFQASWGFWGNTTWLQARVRSILHEGEWLWWINNARRCGLEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6K4</accession>
    <name>A0A7D5V6K4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g108720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543977.1">
        <property type="nucleotide sequence ID" value="XM_014688491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6K4"/>
    <dbReference type="GeneID" id="26243364"/>
    <dbReference type="KEGG" id="mbrn:26243364"/>
    <dbReference type="OrthoDB" id="3429175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF13">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="190" mass="20722" checksum="5F59953931C41C3D" modified="2021-02-10" version="1">MTVTPSPWTSPSPNAVGRILIQLALPILDALGNSDLQTARRLSNLPLTPYIATECARVWKMRAVQIRGDPEDAAWVTRLLITSDGTVVGRAGFHGRPDATGMVEVGYSIDPQHRRQGHARAALAIMIEMARNDPSVRTLRATVAPDNVASRTLIESFGLKEVGEQWDEEDGLEIIFEVGCDVAPEEGRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6U1</accession>
    <name>A0A7D5V6U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g107410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987950.1">
        <property type="nucleotide sequence ID" value="XM_066131728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6U1"/>
    <dbReference type="GeneID" id="90968229"/>
    <dbReference type="KEGG" id="mbrn:90968229"/>
    <dbReference type="OrthoDB" id="5206208at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26248" checksum="46DFFFB48C8D6B6F" modified="2021-02-10" version="1">MTIHNGKLRVKSTYSLSARVERRVVGRVTRSCRVKQELPFICNPVIQNLPSLCAVAISADKLSRSGKFAPRESAESNYEESLPLYSPSLQMEIILPQPPVLILGRGTPVKLVLHTPREIMQSATIYVRSVKLQLKAIISALPRSTWHSVTDTRLGNTISGAVPIKSEHFQLELGAWGMFMAMQSRPSLNSCLLKVAYSLEIVTGLSNGLEGPIQYLTASLDVLVMDPPPPYEAVVANVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMM0</accession>
    <name>A0A7D5YMM0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">IQ domain-containing protein IQM6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IQM6</name>
        <name evidence="6" type="ORF">G6M90_00g028740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541293.1">
        <property type="nucleotide sequence ID" value="XM_014685807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMM0"/>
    <dbReference type="GeneID" id="26245928"/>
    <dbReference type="KEGG" id="mbrn:26245928"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="584" mass="66179" checksum="7D5A822DBE61ABB6" modified="2021-02-10" version="1">MPTSDSAISFGASTSASISTCPSVPKTKEYMDSLVLPSQAKLEHIAQVQEEKEVEARRRARDEWRRRSASGASDGIHHAASTGHHKHERDEAAKVIQKTFRGYRARRELQGYSLNASTRWVTAVREAQFRQGIKPHATAASPSAADGDVLALEDPVDYRPASARQKWKKVSLVARRAGHDASDSESDSDEGDLEGMTSEEKAAAKERRLKATAKRRQAARMLGLQYFLEMVDSKHRYGSNLRMYHEEWKKSDTKENFFYWLDYGEGRFIELDTCPRDRLEREQVRYLSREERQYYLVRVDAEGRLCWVKNGARIDTTEQFKDSIHGVVPLDDPTPAFAPTASQNLHSQDNDDDDNDDDSDSSDESKREADRAAKYADPGFDDSKGLKKVTHISASTIFNQLLRKSVKKNTWIFVADTSFRLYVGIKDSGAFQHSSFLQGGRISAAGLIKIKKGRLSSLSPLSGHYRPPASSFRAFVKNLKEEGVDMSHVSISKSYTILVGLETYLKTRKKGKELVGKLMHGKDKLVAPEEVQRREEEEKDKSESAEKERRVLEREREEADKVKREMSKSDRVMEKIKSLPVHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMP7</accession>
    <name>A0A7D5YMP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxymethyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g001760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542902.1">
        <property type="nucleotide sequence ID" value="XM_014687416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMP7"/>
    <dbReference type="GeneID" id="26244275"/>
    <dbReference type="KEGG" id="mbrn:26244275"/>
    <dbReference type="OrthoDB" id="4686328at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="861" mass="92449" checksum="97560539D502F126" modified="2021-02-10" version="1">MSSITRTVEVGPNPTEWYGTMIVKGIKYSDGSQVAIDKFLGIAFTSPAAVDKDAFNVSVSPWQDVKAEVINEPIDASTCLVTAKLNFEKSYKFNASDTITIGVEADLRDHPEPYTESVRLGADAVPNVNGTVVITTADAPNPALESREVTLSFAQGSRNFTATALPGKTTSIQIPYGKYVVSSSELTTADETVVATSEVSPSSLPVDADQEVAVKVTFGSVQTYGAIDVSIGDIPSLESEMVHVYLTRDGSQFTDFYSKDNETTSLRRLPDSGNVQVSIHAITLNNVQYGFSTKSLDLAAQLFTVTFGQSDVTASPVDTTGFVELPIVMQSDGVTSDQDVSLRMASDELIYTQKVPAKAGTTPFSVPVAPGEYQLQDSSFVVSGTVYAVNGPSTLTVAKDGSTQLNLELVKGANLHVKGFPDVLAFGGLADMTPTNADDFVAARASSVFKYAGNDGAGDSGSFLTDDPATTRTIQLARDIEAKLGDGSSVLPIMISYTVNLSLGDIYTKLQDTTGLTHSFANLILSLNICNTFIDQDHPVPAGFIVNADFLGEGQKENLVDYAMPVREPLQGALDHWSVKATIPDSINDTFAGYTLAVNWLVRTVAPAATFGWQVNIWGGGTSTWIYDSGPGDQQPLDQAKQTADYIKKLGTYASGDYTPDFLAVDRYEADDWTVRAYVPGYFYGPYEWRRYYDFVRYLGLELQVPVAPWQIPTSHAPLVMDAVASDFDSQHWGTGGSYLLGDADVGSDIGNINPTVLDLELNATLIKAKTAREVWQRGEPFDLTQPAYQDFPVRGIFAVLLGGGSTTGIISTVGNAGEWVAGRLRAYADNPIPLDKYPVEASGSGGARVGAIARRRVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN27</accession>
    <name>A0A7D5YN27_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein cft1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">paa-3</name>
        <name evidence="7" type="ORF">G6M90_00g027340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547853.1">
        <property type="nucleotide sequence ID" value="XM_014692367.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26237297"/>
    <dbReference type="KEGG" id="mbrn:26237297"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="88"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="586"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="1055"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1432" mass="155129" checksum="37D311C3B8DE9B3C" modified="2021-02-10" version="1">MQVYTELVPPSAVTHSLSLPLTSASANNLVVAKGSLLQIFSTRSIPAELDPQAQDAQSSVKEDHVHFDRRANDDDGLESSFLGGESLIVRADPSNITKLVLIAEIPLAGTVIGLARVKVKNTPSGGEALLLAYKAAKMCLTEWHPQRHTLETTSIHYYEKDELQGAPWEMPFGDYVNYLEADPGSRCVAFKFGSRNLAILPFTQSEEDLEMDDWDEDLDGPRPVKEEPPLTNGDGPGDHDLVKSRYTPSFVLRLPLLDPSLLHPVHLAFLHEYREPTFGILSSMQSPSAALGIKDHLTYKVFTLDLQQRASTTILSVTGLPQDLFRVMALPAPMGGALLVGENELIHIDQSGKPNGVAVNDMAKQMTSFSLVDQSELGLRLEGCAVELLANDIGELLLILNDGRLAIVCFHIDGRTVSKISIRLVSAEYGGNLIKSQVSCISKLGSNTLFLGSESNDSIVLGWSRKQGQEKRKKSRLLDPDLALDVDDLDLDDDEDDDLYGNDASLAKPSHTINGGSKPGEVSFRIQDALLSIAPIRDVACGAPVLVPDSEEATLSKGVTAELELACAVGRGPSGSVAILNREIQPKVIGRFDFPEARGFWTMCAKKPLSKGAAVASDFDTTGQYDKYMIVAKVDLDGYETSDVYALTAAGFETLKDTEFEPAAGFTVEAGTMGKQMRIIQVLKSEVRCYDGDLGLSQILPMLDEDTGAEPRATSASIVDPYLLLIRDDSSIFIAQIHSNNELEEVLKPDGTLKSTKWASGCLYNDTQGIFQNNVNEQQADETDRIMMFLLSSVGALHVYALPDVSRPVFVAEALTSIPPFLSAAFVARKGASKESITEILVADLGDAISQTPYLIVRHASDDLTIYEPVRCQAEGDAELSASLLFKKCVNTSLAKTAPEVSEDDAEPPRFVPLRRCANVNGYGAVFLPNASPSFVLKSSHSEPRVMGLQGLGVRGMSTFHTEGCDRGFIYVDMEGIARVTQLPSNANFTELGVSVKKIALDGDVGMISYHQPTGTYVVGCTKLEQFELPRDDDYHKEWAKETSNFPPTMARGILKLINPVTWTVIHELELEPCESIESMKTLHLEVSEETKERKMLVAVGTALSKGEDLPTRGRVQVFDIVTVIPEPGRPETNKRLKLIAKEEIPRGGVTALSEVGAQGLMLVAQGQKCMVRGLKEDGSLLPVAFLDMSCHVASVKELPGTGLCVMADVFKGLWFAGYTEEPYTFKILGKSSGKLPLLAADFLPDGEDLSMVAVDAEGDLHILEFNPEHPKSLQGHLLLHRTSFAVTPNTPTSTLLLPRTHSPSYPQASSSSSHMLLLACPSGQLAALSPLAESTYRRLLSVTNQLHPAIVPHGGLHTKAHRYPDPSSVAVGVETAASSGRALVDGTVLARWSELGAAKRTDVALRGGYDGVADLRDDLEGVLGWSAMAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPW8</accession>
    <name>A0A7D5YPW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">pH-response regulator protein palA/prr-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prr-1</name>
        <name evidence="5" type="ORF">G6M90_00g030880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986459.1">
        <property type="nucleotide sequence ID" value="XM_066130076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPW8"/>
    <dbReference type="GeneID" id="26247562"/>
    <dbReference type="KEGG" id="mbrn:26247562"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09236">
        <property type="entry name" value="V_AnPalA_UmRIM20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="6"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="638"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="871" mass="97321" checksum="1BDAA4196C04BB96" modified="2021-02-10" version="1">MATTGSILSLPFRRSTQLSLASVIRQYINSKYDQHPDMFKQDLEVIDALRQDAINVREPHPSGIKKLQAYAGQLAWISGKFPIDIGAEFTWYPALGYNTERPMVRNNIKYELLNVLYNLAALYSQLAVNTSRGTAEGIKTAANQFSLAAGVLSHMKKEVVPLLRMYDPPEDMDEHTLESLMQLFLAQSQECFWQKAVVDGYKDASIAKLAARVSDLYNLAGEAAMKSEAISSAWIHHMTAKHHHFAAAAQYRAACDCLEKRRYGEEVARLTDAVACVTEGLKETKGGYLNKTVVDDLNGLKRKVEEDLKRAEKDNDMIFLNPVPPKSELKMLERANMAVARVPPQVANPFDFLGDRAEFGPALFSRLVPFSVHVAISIYEERRDRMVNQNIIQDLEGLNDKIHSLFSAIGLPGSLQALEKPLGLPPSLVQHAEELRQADAIGRLRKSFTDIDKLRAADIAIFEEGTSALAAEREEDQKARRKYGTDRWSRPESQSDAQGGKLWGHADEIEGYFASSASSDGVVREKFAANEELLHVLCGSDRGLMDFVPSSSQRDTNPELKASVGKLRSAYNDILRLESRRRKKVETLRENARKDDIKPDILKEAARLERTYPSTAIVPAHFEDFFEKRLDRLYEPELDALDKESLEQDRLLKEVERANAEFESQKRRCGDRGSREREQALQKLDSAYFKYKEIINNLEVGRKFYNDLNKIVGQGFRDVVKGWVAQRRMEARVLEEELSMPPLSTLNLSRDHAPLQGASTTQYQAAQPAYFAPEPVAQHHQTSPQRQNDHAAGQSTPNPVEASIQSWAGEAVRQPQPVAPQTTNPMTTMWNPAMGIKFGGSGPPAPRTDGGQQPGGGSATTWNPASGVKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSP2</accession>
    <name>A0A7D5YSP2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(S)-2-haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dhlB</name>
        <name evidence="3" type="ORF">G6M90_00g076190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545482.1">
        <property type="nucleotide sequence ID" value="XM_014689996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSP2"/>
    <dbReference type="GeneID" id="26241515"/>
    <dbReference type="KEGG" id="mbrn:26241515"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="269" mass="30153" checksum="9B8853A51EBBE914" modified="2021-02-10" version="1">MCPATVPPLSSVRALTFDVFGTTVDWRSSVTEELALRAHRKRSSNPPPALKDRLDRLGEDDWGRFAQAWRDTYVRFVGSFDPEQDAWKTIDEHHRDSLVELLETWGLGGLYTDAEVDSLSLVWHRLAPWPDAVDGLARLRDGGKLVLATLSNGNTDLVRDLDDFGGLGFHRLFCAETFRAYKPRPETYLGAATEMGLEPAQVAMVACHMGDLKAAKACGLRTIYVERPREEAWDKEGEEFTAARNWVDLWIGEEDGGFVAMADKLLDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSV0</accession>
    <name>A0A7D5YSV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Target of rapamycin complex 2 subunit ste20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ste20</name>
        <name evidence="5" type="ORF">G6M90_00g041910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547532.1">
        <property type="nucleotide sequence ID" value="XM_014692046.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240095"/>
    <dbReference type="KEGG" id="mbrn:26240095"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="4">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1330"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1342"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1354"/>
            <end position="1363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1383" mass="153602" checksum="BDB83867B702BC41" modified="2021-02-10" version="1">MPGQPSSQHNAPSQYNPTSSQAGTGRTSIDRDGSGLQPLNGVPSRNLAASAVSFAPRGSSLNPTIGPGSFSSELRSQTISSRAGSRMDVGSMYTGSIMDKVEEDGTEAAMQQALSTLRDKLNREMKIKEGSENMLEALNIKKAKQTKEQRQRVEVELSASNLRIKELRQKISEAQRTRAPPPTTPTRNRAQETIFQSNGLRSPPSISRSAAGSDLDDAAESPTFALAELLQALEVEGMTPEYYVSRANQLVDLFKRHPALKYDLVWAIFGLRMQMMLLSESREVVAVGYRVARYAISDSASIKRIRSFNTDYLVIRSLSNYRKADVEREQALKFVRAFLDVKDGIKEVSRAIVRTIVAVAEQGEDRRPGIHAADQSIDRLRPICIETLAEILVRDPALLIASGGLGTLSEALAEGTYKSPESLTSAFLFLLDSPQKRKYIIPGYGLDVVFTAFTDLLAGADGILKQTSGAISVALRSWSGLMTLSMYDFRPIRSLIASILFPSQNVRETVLDLLFSLLRIKPPAWATSFLAGRRLTTYGRVANMKSAARRRSGTLDMEEDSGEQSFVDHYTALLLAVFIKSGLLQSLLRMVQTEEDPMLKRKSTLLIGEVLKLSSRLLPPSWSADLQLLPELFSAAAEFDNEGHFNASGIIYQISSVSRTLYRSAPSESLAGGLPSSDSMRNLARFDEQPKSSNPAVALDDATFRQLLIDSGVLNSSNYMKWNWEVILKIIDGPLQTGKRLDEAVKASKFMKRLMSFYRPFKYKFAEVKNTRGTQKYVRAGCALVHSLLQSPEGIKFLADSKLLRQIAECLAQCDPTSGLTAQFPMFSKDRLTDTLCGGYFAMLGVLSSEPKGLLLLERWRMFNMMYHIVDFKQRPDLIKLLLSNFDYGLQGHPRVLLSKALTAGTKDIRIHATNALRKCTIGPVANISGDNEVSDSKWAIRLLVTQLYDPEIEVCSTAIKILESACNKKVYLEYIVQCRPALDHLGEIGAPLLLRFLSTSIGYHYLDGLDYISNEMDDWFLGRNDSYVGVIEAGLARAFLADPDDNSHRLSLFDESDPEAGFHDSHVPPHFYRELTRTREGCKLLRDKGHFEEFVTTIREHGMQTEDAELITKVKGCLWAVGNVGSMELGAPFLESSDVVERIVKIAEGHEVMSLRGTAFFVLGLISRSTHGLEILSEHGWDANTTSMGTSLGLCIPNDLSKFFSVVPWQHVNAASITIPDTQRTIQAQPPIQKARPPLELSELPPLLSDEDVNGRILELVVDLGNMVLYKKALMELQKLKQRKPNAFRSTDFFKKVMGLMEWNHYRLGIRRLVIDLFEKNVMRQIVFGDDDTEDSESTSGQGGNDNGDGSSGDDRTERQRSISEPAEMPSDLMPAPLRVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT95</accession>
    <name>A0A7D5YT95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g071210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545937.2">
        <property type="nucleotide sequence ID" value="XM_014690451.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT95"/>
    <dbReference type="GeneID" id="26241970"/>
    <dbReference type="KEGG" id="mbrn:26241970"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="434" mass="49020" checksum="F3DBD07D9AA96E70" modified="2021-02-10" version="1">MVPQNKESFERRMVVIKDGVEITPVRWADDQTFPYNNFIYKVELSSPALAEHFTGSEQVWRRQPCTDLPPTEGVSTVIVRMSNPRAMGLNNTNRIENEVAAMHLARGAIAQLGSRYASLVPAVYAWKAAAGPHPVDETGFGWIVMEYLTGSPLHEQFKSFDMAEKKLIIPEIASIFSSIQRVELPPGVDCFGGFTINKEGNIISGQETIQGAPGGPWREYDEVWRHQMLCQLKEADANELIQGWRVHGIRERIEQFLNVTLRRVLQDAGVDMSKLGFVHFDFTMSNMLYDAEEKRISGIVDFDFAGVNNPAHEFFFTSLHDVHGTTREQKSDKLRRAILTGNFGASTEAGEEEHADAWELAKLWDEVMGERGGLRPRDIRGMTTLAKLNTLTDMLFPWQLGSVDMLRRQTREENAKMRARAEKAIDDMLSGWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTH1</accession>
    <name>A0A7D5YTH1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrogen assimilation transcription factor nirA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nirA_2</name>
        <name evidence="1" type="ORF">G6M90_00g075990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545501.2">
        <property type="nucleotide sequence ID" value="XM_014690015.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTH1"/>
    <dbReference type="GeneID" id="26241534"/>
    <dbReference type="KEGG" id="mbrn:26241534"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="629" mass="72422" checksum="1C775479CB24584B" modified="2021-02-10" version="1">MECHYTTQPGERQSQALKRAYSHLQYQATAHEELFELLKTVPTQEAHDILNRIRHGTDVVTILNHVRAGDVLVQMAVEPETRFRYEFPYKSELPQDYVQHNPYLDSIIFEATSLYATGQDSTPSASSTTNSAPNSASGAYESLYLKPFHASEVIEPQLSKAKISWWTAVCQDDVLMRDLLRVFFRCEYHFAAAFQKDLFLQDLAARRQDFCSALLVNIMLAYSCVCYPRFSNRAEYWNPNTLAYRFLAEAKRIWELEATEARITTIQAGILFNVFHNLCGLDEIGQAYRIQAIKLAHQLRLFDSSVYMHDHRMRNGRAFAAWSLFNWETLVGFSFLFPPLLKTPPDWPLPDPSKETGFYGEVWVRYPLTRSLSPSSFGPVFKARSEFRIIMNAYCQAAFSEGSQVTVEKANGFLSRLRCWYDGLPAPLQPKTIVLPGHLQLHMYYHHLILTIYEPLLDVATEGEPTPQQIVDDARKHLQTLVRLYYLRHGFEAMDLFIVVPLMLAGYECIDAIGEQATGPRLEALRSTLILIAKGLYNQRRNHYLAEALFRVIRGRMRQEELSLLKTTVRLDEDEEDERRHMAQAVRSHWPVSVVKRKEDVNSHILKNLVETYAHLNVDEEPAPAEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTZ9</accession>
    <name>A0A7D5YTZ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regucalcin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rgn</name>
        <name evidence="5" type="ORF">G6M90_00g016110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548918.1">
        <property type="nucleotide sequence ID" value="XM_014693432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTZ9"/>
    <dbReference type="GeneID" id="26238362"/>
    <dbReference type="KEGG" id="mbrn:26238362"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="17"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI63825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="297" mass="33004" checksum="611791D5A1BE1B28" modified="2021-02-10" version="1">MQHWTVAAPWLDLHCSLAEGPFYEKGTDSLRFVDIKKKRVHTVSLSRGLSSLHTIQLDICPTVTADIEGVDPRERILLGVKYGLAGLDRETGAYEMLARFNDPDNERLRSNDGAADPHGLFWVGSMTDFGQGEFQPEGSLFRFSKDGKEEMVKGLTIPNSIGWSPDNKTMYYTHSKARQIFALDYNAVSGAVSDHRLFYKHPTSGEPDGFRIDVDGNLWTAVYGESKVLKINPEGKVIGQVTLPTRNITCVQFVGTELIITSAADEDGEDKTSRDYGGALFRVDVGTTGLELFKFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU82</accession>
    <name>A0A7D5YU82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA modification GTPase MSS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MSS1</name>
        <name evidence="9" type="ORF">G6M90_00g063020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986848.1">
        <property type="nucleotide sequence ID" value="XM_066130754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU82"/>
    <dbReference type="GeneID" id="26244529"/>
    <dbReference type="KEGG" id="mbrn:26244529"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="206"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="479" mass="52183" checksum="850E41D8C94EA732" modified="2021-02-10" version="1">MSTAQIYQGLCPGKPPPKPRRATVRTLLDPASNTETNILDVEALLLHLPSPKTVTGEEVLELHVHGGPATVKAVLSAIPKCQASTRIRYAEPGEFTKRAFFNGRLDLAQIESLGDTLDAETEQQRRAAVRGNSGALGRSYEDWRHQLLQARGEIEALIDFSEDQHFDESQSELLENVARQVAKILRSIDLHELGSQRSELLRNGIRIALVGPPNAGKSSLMNIIVGREASIVSGEAGTTRDIVEASLDIRGFLCSFADTAGFRSKTETSDEVIGAVEEEGIRRARARAQESDVVLVLASVEPGPSGPFIHFDKETMALATEAQSSLVVVNKQDTVDGDVLSHLLRQFRQLIREEYPGLPQEPICISCKEDGSASRDSGVQSVVDALVASFSQMTDMPPDMRDLLGVTERQRQLLAKCRGHLEDFMGEAQPQKGLDSDIVLAAEYLRYAADCLARITGKGEAGDVEEVLGVVFEKFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV98</accession>
    <name>A0A7D5YV98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonribosomal peptide synthetase TES</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TES</name>
        <name evidence="5" type="ORF">G6M90_00g052690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986932.1">
        <property type="nucleotide sequence ID" value="XM_066130549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV98"/>
    <dbReference type="GeneID" id="26246758"/>
    <dbReference type="KEGG" id="mbrn:26246758"/>
    <dbReference type="OrthoDB" id="4895341at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="254"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37289" checksum="EE12EA4224F53E8F" modified="2021-02-10" version="1">MVIDRQCTAQLPKFNTPLPEIGPSNAAYMLFTSGSTERPKGIVVEHQNLASSSFSQGGQFKINQSTRVLQFAAYTFDISCADIFITLQRGTTICIPSEYECINDLTSAATKYRADWMSIMPTVAQPIDPESVPSLRTLVDLQRLLSTLQLIAVLALSNISGRGVPEHEQLKPLRGKDNQAASDQIATIRQLLEERLPDYMIPTVWICVETMTLTRYGKMDGTAVAKWAENFDHEAYQDLLLDSNEYDTKVESAVAVSGQATVIPTLASQVLGIPVIPMNRCFFGLGGDSITAMQLRIKARAAGIDLSVRDILKAKTLFGMAEAATPLNSISPFPIAEIDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW56</accession>
    <name>A0A7D5YW56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump vrtL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">vrtL_2</name>
        <name evidence="8" type="ORF">G6M90_00g082160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543447.1">
        <property type="nucleotide sequence ID" value="XM_014687961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW56"/>
    <dbReference type="GeneID" id="26243624"/>
    <dbReference type="KEGG" id="mbrn:26243624"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="512" mass="56444" checksum="7242F016B7497E6D" modified="2021-02-10" version="1">MKRGSCPPSPPVPLLSAYACDMAASDSASHDVEAYHAAGPDFKLDTDDPIVVSWDGPHDPENPKNWKAGRKWGITILVSCFTFISPFSSTMVTPAMDVIARDLQVPAGFMQQLVMTIFLLGFAQGPFVLAPLSEIFGRAIVLQLSNVMYLVFNLACGFAQTKEQMLAFRFLSGVGGSAPQAICNGILADCWRKEERGKGQAIYGLLTFLGPVLAPILGAYVSIYTTWRWIFWSTSAFDLVVQVAALFFLRETYGPRILLQKARRLTRETGRRHVTEENRPLSQVLRRRILVPFIMLFAHPAVQVPSLYRAYLYGVMYLVLHTFPLVWVGTYGMAKGPASLNYLSLGIGFIIGLQISHPLIDKLYVKFQTKYGHEDGLPEWRVPPMIIGAVLCPVGLFVYGWTAQAGAHWILPNIGCVILATGLIIAFQSAQAYVVDAYNEHYAASAAAAGAFVRTMFGFSFPLFAPKMYQALGLGWGNSLLAFTTIGIGVVSPGLLWFYGHKLREWSGMGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWA0</accession>
    <name>A0A7D5YWA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase kappa 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gstk-1_0</name>
        <name evidence="2" type="ORF">G6M90_00g015420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548985.2">
        <property type="nucleotide sequence ID" value="XM_014693499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWA0"/>
    <dbReference type="GeneID" id="26238429"/>
    <dbReference type="KEGG" id="mbrn:26238429"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26342" checksum="3ADED6CA1764E6A1" modified="2021-02-10" version="1">MAGGRIDCYLDLASFFSYICIADLRLNLDKLAAHGVDVEFHPIFLGGINHLSGNRPPWTLPAKARYLIYDNKRAAARVGITEYQAPDDLFERAKTQSALRALLFIKANYPKEKLLSAMHFLLHKFWTPPNADVVDESSLRALLAQATETPGGGAKLFTEEEVGRIMDGRAEMKKKLIEDTAKVVESGAFGCPWFLVTNSRGETQPFFGSDRFNHIYMHLGIPFQDVAILPPSSAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYL4</accession>
    <name>A0A7D5YYL4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g093790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987753.1">
        <property type="nucleotide sequence ID" value="XM_066131461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYL4"/>
    <dbReference type="GeneID" id="90968141"/>
    <dbReference type="KEGG" id="mbrn:90968141"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028899609" description="Rhodopsin domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="178" mass="19243" checksum="7C03E2EDCEDBEDA3" modified="2021-02-10" version="1">MTDSVQMLCLAFTVMTITCVSGGAFGEEAWNVVLSSFTKSQLVLGLLVEVVSPLAICFVKISVFILYLQLFSVLQWMRVVSITGIVVISVWHLSISIAFAVMCSPTGSSQLDFLAALVSPMCTRTRSLVVTQGVGNVVTDVFPLVLIYVTIGKAKTQRAFTILSLAPIQRRRAIHGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZJ8</accession>
    <name>A0A7D5YZJ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g107330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987963.1">
        <property type="nucleotide sequence ID" value="XM_066131723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZJ8"/>
    <dbReference type="GeneID" id="90968226"/>
    <dbReference type="KEGG" id="mbrn:90968226"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16558" checksum="C2FCA24956520678" modified="2021-02-10" version="1">MSIAARYGTDCHLRSPFSNLNTRLVEYLLRQGADPAAFRGYEISSVYSVAFLPKSWATCRVLSLFLEAKTGCRGVNLNPYPYGSPLQVACYVNRQEHARILLSECVEVNATSGRLGDAMQSASRLGHGGLVTDLLQRGGDADSGQDSWPRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZM6</accession>
    <name>A0A7D5YZM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Benzoylformate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdlC</name>
        <name evidence="6" type="ORF">G6M90_00g029330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541236.1">
        <property type="nucleotide sequence ID" value="XM_014685750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZM6"/>
    <dbReference type="GeneID" id="26245871"/>
    <dbReference type="KEGG" id="mbrn:26245871"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="5">
        <location>
            <begin position="69"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="4">
        <location>
            <begin position="487"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="664" mass="71161" checksum="578E8BA781900C9D" modified="2021-02-10" version="1">MALRTRLARKVHFRPLPPSAASRRFRPLARLPPSPESPPAAPFSTSRYSRQAPDRASMAASQLTQAPYTTAFALFEALWEAGITACFVNVGSDHPSVLEAIVKGKRERPNAWPRIITCPAEMTAISMADGYARVSGRPQAVLVHVDVGTQALGHGVHNASVGRVPVFIFAGMCPYTEAGELTGSRTEYMHWLQEAPDQKAIVRQYCRYTGEVRTGLNVKQTVGRALQFASSAPKGPVYVAGAREVLAQEVQPYSLDQAQWVPVGPGALPEDAVAAIARALVQARRPLVVTGYSGRDRRCPGLLVALADLVPGIRVHDTGGSDVCFPFEHPASEGFRLAFDECTRDTDLVFLLDCDVPWIPARNPPPDDATIYHVDCDPLNQQIPVSFFPAHGRWKADSFTALSQLVEYIKNDAALAKQLQDPEYAARGAAREKVHASRLAEIAAQARLGDDEPLNAANIGSLLKTALPESTTFVIEAVTAAQTLSDQLQPSRPGSWINCGATGIGWSNGAALGVKMALTDLESDQARQHSLVCQVVGDGSFMCAAPSSALWVASKYEIPVLTIVLNNGGWKAPRNSAQLVYPDGLAAGATDDEINISFCPTPNYAALAEAAAGSGAGGGGLADDDGAWMRGVRVKTVADLKRALEMVESRVIQQRKGMLLEVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZV9</accession>
    <name>A0A7D5YZV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Molybdenum cofactor biosynthesis protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Mocs1</name>
        <name evidence="10" type="ORF">G6M90_00g013040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549219.2">
        <property type="nucleotide sequence ID" value="XM_014693733.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZV9"/>
    <dbReference type="GeneID" id="26238663"/>
    <dbReference type="KEGG" id="mbrn:26238663"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="339" mass="37953" checksum="C4B46044FC5970A5" modified="2021-02-10" version="1">MPEEGVPLSPNRELLTTPEIVMLSSIFVSQGVNKIRLTGGEPTVRRDILSLMRQIGALRPRGLKQLCITTNGISLHRKLDSMVEAGLTGVNLSLDTLDPWQFQIMTRRKGFDAVQKSIERILEMNKVGAGIKLKINCVVMRGVNDREVLPFVELTREKDLEVRFIEYMPFDGNKWNKGKMFSYDEMLDLIRGQFPGLAKVKDDKNDTSKTWHIPGFVGRIGFITSMTHNFCGTCNRLRITGDGNLKVCLFGNAEVSLRDILRKSNRGEPIDEEAYEAMKQIEMDRKQGRVPPDQPLGVAPNEAELLDVIGIAVKGKKAKHAGLGTLEHMKNRPMILIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZY8</accession>
    <name>A0A7D5YZY8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g024900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548091.1">
        <property type="nucleotide sequence ID" value="XM_014692605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZY8"/>
    <dbReference type="GeneID" id="26237535"/>
    <dbReference type="KEGG" id="mbrn:26237535"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="73508" checksum="251D96C432238BF8" modified="2021-02-10" version="1">MSLTPPEYLFVVRHGSRLDAADKSWHLTSPTPYDPPLTYGGFLQARRVGNQIASILEQAKAADETRLTLNGSRKRKRFKVVIHSSPFLRCVQTSIGISSGLAQFLPNSMYNPSDLILPRAVPQTEPQFQFKSTLLRLDSFLGEWLSPEYFEMITPPPGPALMLGGAKAELLRREDYSIYDDVPELEAPQPSSGSLWQSPTLSPAQSPRSSSTDSEESINMSALGAALPTRPDVKRGYIPPRPIYAASSSGSIPEGFVAHARDASVAVDYQWDSMRAPLDFGDGGKFGEEWASMHKRFRRGVRKLVNWYASTESPADLVPAKSAMDDHSGAEHESHDGDVETVVIMVSHGAGCNALIGAITHQPVLMDIGIASITMASRKQNLDYKELLASTPAPPDSSEKTVVAVDKMYDIRLSASTEHLRRSSLSTPISAKSNLMSNIWNTNNGSRGRTSTLSSIGGPVMSPFTYSDPFSSTGSRSTSASAALPPIVRRDSASQRPLPRGSALASVGFGHGAGSPNTGNRSPPATSLGFGLWSAGPPSAGPSSLRLMDDGNDDVDDFGSILPDFDQKRFKMSSPTKEEKEPDLPAESTSSSAIIDDAPTFPELPPTRADKVKGAPTPLMFAGPIKLNTNLGPNKPVEEMKVRQLGAGLGGLWGIPPPPDEAERFRDMSHTKRRWTVNERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZZ0</accession>
    <name>A0A7D5YZZ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase-like protein sdnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sdnR</name>
        <name evidence="5" type="ORF">G6M90_00g112150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987795.1">
        <property type="nucleotide sequence ID" value="XM_066131850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZZ0"/>
    <dbReference type="GeneID" id="26246880"/>
    <dbReference type="KEGG" id="mbrn:26246880"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF97">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028883830" evidence="2">
        <location>
            <begin position="19"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="102"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="434"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="588" mass="63425" checksum="DCA3977EC2E756C4" modified="2021-02-10" version="1">MLLYLCFFSLSCLTSATAAFDQKVLGQTYPFPENLGSAHAVRTASSYISHELQNALDTGLSKFGNITAKTNSLSATMISAQDSQPFLDFHYSAANLNVSGGSTNRVTGNSVYRIGSISKLFTVYSLLLHGGEKIWDMPVTNYLPELRKAVSQTGANSAIHHVQWDKVTIGALASQLAGIGRDVNNADMASQPFPHQAAGLPELSLDEIPTCAGNNTQPPCTRREFFDVLLKRRPVSLPFNTPTYSNAAYRLLGYVVEAVTGTSYTEAVAKSVFQPLGLQNTSTSSPRGTGVGVIPPGNSGWGRPLGDEVSTGGLYSTSRDLAQFGRALLNHRQLSPLQTRRWMKPHAHTASPFFSVGAPWEIWRTRSQISSGYTIDLYTKSGSDDQYQALLILVPDYNIVASFLCAGPNAGPAINMAAEVALQSILPVLDRVSQSQAVHRFGGRYVSSDAKNSSLLLTTDHQGPGLLVKEWLSNGVNVQEAAQAYSDGTGGGTIKSIRLYPFITNTEDASSTGSSGTQVSFRAILETEPVNYDPGVLRILNADAGQWGRIDQLMYGEIAVDDFIFQLDGHGIATAVQPRVMRDTLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0H5</accession>
    <name>A0A7D5Z0H5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g057850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544365.1">
        <property type="nucleotide sequence ID" value="XM_014688879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0H5"/>
    <dbReference type="GeneID" id="26242777"/>
    <dbReference type="KEGG" id="mbrn:26242777"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="34779" checksum="1BFBBBD3647E4032" modified="2021-02-10" version="1">MSLSAPGSHIRLQLRRALSISHANFSTSAPAQTIRVPPESPSYIRLPTPPQSDETKPPRVRGHLPVPREIFPRVEGSRKIQPEYIKKTAPRSTKSSRESPSEAQEWKTALAETRRTNLKEGLDALWLRRREMDRSRNERVSHKFYKHNKAGAAPERDDDKLTRPTVLTAIMDTKVYPDPDRFARADRSRTKVLAKEKQKMEARRDALMELYTSASNFIVHENELKAKIDEVFAEDYFRKRSEDGHRHGTTGNMWGSYGKPPSIANMMESAIGTSTRIMEADQTESDRSAKRQKRIAEDLTGGKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0K1</accession>
    <name>A0A7D5Z0K1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">img2</name>
        <name evidence="8" type="ORF">G6M90_00g044360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547770.1">
        <property type="nucleotide sequence ID" value="XM_014692284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0K1"/>
    <dbReference type="GeneID" id="26240333"/>
    <dbReference type="KEGG" id="mbrn:26240333"/>
    <dbReference type="OrthoDB" id="19439at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="162" mass="18277" checksum="7E09A7F4DED71066" modified="2021-02-10" version="1">MHQHVSRALCRGQNYLSQSNIYRTTVIQPSNLPTCRFASWSQSSRSLSTTAATKPARSYTPVSRAPTPPPTKSPEELAGASYIVRRTPSIQLPVYRRFASGGNREVVLIKKVDGDRKKLLEDLVETLGVSKQDIRLNPTTQHIELKGDYYEKTKSWLLERGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0V2</accession>
    <name>A0A7D5Z0V2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein bir1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bir1</name>
        <name evidence="4" type="ORF">G6M90_00g021400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985670.1">
        <property type="nucleotide sequence ID" value="XM_066129873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0V2"/>
    <dbReference type="GeneID" id="26237851"/>
    <dbReference type="KEGG" id="mbrn:26237851"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="793" mass="85594" checksum="FD51599F1F971F29" modified="2021-02-10" version="1">MDQYFTYEARLASFQKTSKKRGSTAGGRSKALNWPHKQIAPASLAIAGFYFDPYPENPDNCVCFLCGKGLDGWEAGDDPLEEHLKHSPQCGWAIVSAIEAEIDEYSRQDPTLPHMVEARKATFAGKWPHEGRKGWKCKTKQLVEAGWKYTPTDESDDMATCADEHYNRSPNCTFFALVNEFGGPKKRTARGKAAGVSKTSRLSMQSVATTASDIASVADMTAEPEDSILTTTSTATQGSKKTASKKKKPATTKGRAKTKKAQGIEREEDDTVDEEPVSLPKATKATHGKKRTSDAIDDSVLFLSEAPASKKQVTQNRESSQIDSSTITPEDVEFVDAQASKSAGRARSSSVKSSRKPSALGASVASLRAPLADFPDDDEIERQLEADLERALTDDDEIAHDSESERSKAMANKKSKGKLTDEQLEDYAMFDPAEVEHDEDALDDELRNLQAEMEVEEPNQKLHVPKKGRKPGTGIRKASKQTKAKKAKAPSPSPEPEPEAIDPPSEIEEHEASIGSTDAVVKNTDTVDSPPSIKAPSRAVKKSSLASNAASKPAEAPARRGRRPSSTTAEPIQPSESTQPSEGHADDEVSEADGETHRRESAGTPQLEEASSPLEEASSPAVSRSRLGVEPPSTPPKFTSPAPSARQPALSPSPSPQSSDAENLPPSSLPPASAKAKRVVLAPLAATPARNSPSKRNMLAAGLQSQIPWTAVDIDAVMGTPRCGDDKENAVSRLLKQGKELSSPETRMTVEEWIHFNAGEAEKKLKHECEAMVTQFEREGTKAMNVLESLSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Y9</accession>
    <name>A0A7D5Z0Y9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GPN2</name>
        <name evidence="7" type="ORF">G6M90_00g006880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986128.1">
        <property type="nucleotide sequence ID" value="XM_066129620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Y9"/>
    <dbReference type="GeneID" id="26239265"/>
    <dbReference type="KEGG" id="mbrn:26239265"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="36198" checksum="87CBEA85953B7C75" modified="2021-02-10" version="1">MPFAQLVLGSPGSGKSTYCDGMHQFMGAIGRACSVVNLDPANDHTNYPCALDIRSLIKLEDIMKEDRLGPNGGILYALEELEHNFEWLEEGLKELGDDYILFDCPGQVELYTHHTSLRNIFYKLQKSKFRFVCVHLSDSICVTQPSLYVSNVLLSLRAMIQMDMPHVNVLSKIDKVSAYDELPFNLEFYTDVDDLNYLTPYLESESPALRSERFAGLNEAIANMIESYGLVRYEVLAVENKKSMMHLLRVIDRAGGYVFGGAEGANDTIWAVTMRSESSMLDVQNIQERWIDQKEEYDKMERDAEEEQARLAEEQAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1D2</accession>
    <name>A0A7D5Z1D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g066900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539556.1">
        <property type="nucleotide sequence ID" value="XM_014684070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1D2"/>
    <dbReference type="GeneID" id="26247639"/>
    <dbReference type="KEGG" id="mbrn:26247639"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="12">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="43793" checksum="6FBEBE7F9A5E004E" modified="2021-02-10" version="1">MAENIAGYTVHDSLETVLSTVKGTNGDFDIYHRQNDCPIAHEQCNEDHDVGFEGWNLDKYKNVHIAEQAYKMRPDYDWYFFIDADTYVSFPTLMEWLPAVDPNKLHYIGHEKHSGSFPFAHGGSGYLMSKATMRRMFFGKTRVGNKYDEATQDGCCGDIMWSEIVLNETGLTPENMWPVINEFKPRTFNYYEDQWCQPLITLHHVNGEEINDLYAFERGQNFAKRITIKDMYYRFVATHLVESRSDWDNGGEDVYYLDREARTYEESELEKAKTDELSEKELVAHKNSSSCKDVCYSQEDCFQWRYRDGICGLGYNKMRLGNAVKKDDDEAKRSFSGWHMNRIKKWIDEQGNCSETYQWRVTDEQRNRDAGAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1H9</accession>
    <name>A0A7D5Z1H9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Repetitive proline-rich cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548679.1">
        <property type="nucleotide sequence ID" value="XM_014693193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1H9"/>
    <dbReference type="GeneID" id="26238123"/>
    <dbReference type="KEGG" id="mbrn:26238123"/>
    <dbReference type="OrthoDB" id="3561626at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028889697" description="Repetitive proline-rich cell wall protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="52654" checksum="AF17E9097810E03B" modified="2021-02-10" version="1">MRSFIVGLACAAVAWAAGGADELDARWNEPTRTTTIVTYTTVTVCPYTTTVTHGGTTVVVTKSTLSTVTLTSCRGCEGATVTVPGPTVTQGTTTLVDITYTTVCPVTETITAPGSTYLTTKTVTSSVVTKVLTTIYNTVVQPGVTKTATDVVLSTITSLCPVTQVTTIGGKEQTVTFTTTSLITTLVPVTEHKTVVQPDRTKTATDVVLSTITSLCPVTQVTTIGGKEQTVTFTTTSLITTLVPVTEQKTVVQPDRTKTEVHGVTSIITSLCPVTQVTTIGGKEQTITFTTTSLIETVVPTTLQQTVTQPGQTITATDVVKSTITSVHPVTLVTTINGKQETITTTATSLIETQVPVTVTKTIHGEATTETLTNVAYQTVTNLVPVTEVVTVGGEKVTVVNTRTEVVKVAHSSVIFQTVTAPGQTLSSVHVLTVTETLGGGLATQTVTVPGGPGTPVVIQSTNTVHQSAPSSTLVVTQTSAPVVTAAAQAHAPAVGYLFAGVMGAMALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1K8</accession>
    <name>A0A7D5Z1K8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chanoclavine-I aldehyde reductase fgaOx3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fgaOx3_1</name>
        <name evidence="3" type="ORF">G6M90_00g071140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545944.1">
        <property type="nucleotide sequence ID" value="XM_014690458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1K8"/>
    <dbReference type="GeneID" id="26241977"/>
    <dbReference type="KEGG" id="mbrn:26241977"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="376" mass="41343" checksum="6AC787D518C81B7C" modified="2021-02-10" version="1">MASSNLFKPLSIGNITLKHRLALAPLTRFRASDEHVPLPIVTDYYKQRGSVPGTLLVTEGTFISAQDGGYSNVPGIWNQDQIDAWRKVTDAVHKNGSHIFVQLWSLGRVAAPDVAAKEGITILGPDTIPATADSPQPQKLSTAQIQQRKEAYVAAAKNAIAAGFDGVELHGANGYLIDQFLQDVSNQRDDEYGGSVENRSRFAVEVAAAVAQAIGPERTGIRLSPWNTFNSMRMADPVAQFSDVIARLDRLGLAYLHLVEPRISGNIDVETEDAESLEFAYRLWRGPLLVAGGFTPETARRLVDEQHPDRKIVVVFGRRFISTPDLPYRVQKGLALAEYNRDTFYNAKDPVGYTDYPFSQEFINSKEGQAIKVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1N5</accession>
    <name>A0A7D5Z1N5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g022880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548267.1">
        <property type="nucleotide sequence ID" value="XM_014692781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1N5"/>
    <dbReference type="GeneID" id="26237711"/>
    <dbReference type="KEGG" id="mbrn:26237711"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="44"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="483"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="733" mass="80916" checksum="889F1C3C75362975" modified="2021-02-10" version="1">MTSMAAESATTILCTAKQTRFHIESPNYRELDVQGLHILVTSGEQASSTAKAKSKRSDGLEILSNAKLLLKEGQRYALVGRNGTGKSTLLRAIADKLIPGIPEGTRIAILQQTKLTDDDGDENSRQGRKAEASVLQEVIDRATARDTIEQEIKALSDGVDASDPFGPVRALRSLKHHRLQKRLFRMDKEARLRSGARGMQARKALVAFEKVVADSDVMINQSSDEISPETLQAETQEAADMLAELQIQVEPSRIAQIETRARTILTGLGFTEERMGKPISSMSGGWHMRAALATALLQDADILILDEPTNFLDLLGIVWLQRHLQHLAEGDRPPTVIMVSHDRDFISVCTDLMILKEKQLTYFHGDLPTYEASQAERKLWLKKMKAAQAKQRAHMEKTIAQNIKAGKANDDQNKIRQAKSRQKKLDDRMGLQVSAKGHRFKLNRDMVGYFHTAREDIDVPPEERPVVIALPEPPDLRFPGSLLSLDNASYRYGPRLPLVVDGASLTVGMGDRIGILGLNGCGKTTLVRMLVDEARPTAGSVTTHPRLKLGYYSQHAVEAIKAVGRADPALTALGLLTREVDGQMGEGEIRGLLGELGLPGRVASDTPLCKLSGGQLVRCELARLFWRRPHCLILDEVTTHLDYETVTALRVALDGWDGAVVLVSHDRWFVRGVVEGNLDDDGDDGEQSDEEGEAAPRRRIVYRLKGGSMTPLEGGVEEFEKSMEKRVNKLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Y6</accession>
    <name>A0A7D5Z1Y6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin family protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">art1</name>
        <name evidence="2" type="ORF">G6M90_00g033820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986190.1">
        <property type="nucleotide sequence ID" value="XM_066130136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Y6"/>
    <dbReference type="GeneID" id="26244110"/>
    <dbReference type="KEGG" id="mbrn:26244110"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="188"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="404" mass="44818" checksum="D6193269AF86371B" modified="2021-02-10" version="1">MASAPASVRVSGPPNSSFLIGYPGISATLPRIEGKVEIRPGQGYSMPVPVSLVRICLQRRETIHPDADSLTKRHLGTPRKETTDVVGKEVLLFRCATGKEAESVIAMDLPFVLFIPFGRGGEETNRRIPPASLQLPSRTAETYYELVVTVQQGHSNQYKYNFPVPLQRYDTLSTFGMYNKPETKLVTSDNVVHLGINLPRWSYGPGDPITVYIKLSPNPDWLTKAKRVSIEKITLAIEEEVTYNHEGDEPVKKVNKLCKQLQTVKMKVPEAGYATNIGLVFPCKDLRDPDGIVRRGKPAFPLYEVSSFTTTASLYKIEFYLSIKVQLSGARDVNLRQPIVICPLDQQACKEEMDAIEQAAKDAAHVDPNNPMLPARTIILANDRDSLRALGLCLVGGQKKPFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2A7</accession>
    <name>A0A7D5Z2A7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g063820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542503.1">
        <property type="nucleotide sequence ID" value="XM_014687017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2A7"/>
    <dbReference type="GeneID" id="26244452"/>
    <dbReference type="KEGG" id="mbrn:26244452"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028818881" description="Peptidase M43 pregnancy-associated plasma-A domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="12">
        <location>
            <begin position="141"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28426" checksum="2F7796ED1B1E1D97" modified="2021-02-10" version="1">MQPLISMVLASFVRLGAAFTTPGHVRDSPCGVEQPSAALLAAHREIAATEKNHLLRRNETTDTPPAIAVDVYAHIISTSETAKDHHDNNTIHEQIALLNTYFNPGNISFVLKNANWTVNPYFSEGNNTMRMKILHHKGDNRHLNIYYGKNPLGATNSRAVSTTPDDLVGQPLGLEMDGIMIPAYWLYGDRKQTVVHEVGHWFGLLHTFNDDCNGNGDEIDDTPAHADASEGCSAMPPLDTCPGKPGNDPVHNPMNYIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2I7</accession>
    <name>A0A7D5Z2I7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxypeptidase Y inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g085170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541074.1">
        <property type="nucleotide sequence ID" value="XM_014685588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2I7"/>
    <dbReference type="GeneID" id="26246063"/>
    <dbReference type="KEGG" id="mbrn:26246063"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19125" checksum="FF2F506BFFAEFD78" modified="2021-02-10" version="1">MPSNTNAMGALAAVQNDKSKILGVRMGRHTVEPGLHIPKAEARDEPVVRFDGANTSTKYMVVCLDLDAPHPSFPFLSPILHWIQPGLQAANEGGQRVLRASEPSISDYAPPGPPPGSPPHRYCFFLYGQPASLDGSKYASVDGAKMGLWSRMRYSLDTAEKELGLGPIVATNYFTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3A1</accession>
    <name>A0A7D5Z3A1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g080460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539377.1">
        <property type="nucleotide sequence ID" value="XM_014683891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3A1"/>
    <dbReference type="GeneID" id="26247821"/>
    <dbReference type="KEGG" id="mbrn:26247821"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16804" checksum="15A5FD57C0FF0B20" modified="2021-02-10" version="1">MPSIHTEVEINCSPEQVRKTFLDFSSYPSWPTTFIKSIAPVDPNKPIEAGSRLTIELEGMSIKPIVVTNSADEFKWVGKLWNMPGLFTGYHYFKFMPSVKTAGATTFVQGEDFSGILSFLMAEGSRFGSSTKKGFEGFNQDLKKRCESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3N2</accession>
    <name>A0A7D5Z3N2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bikaverin cluster transcription factor bik5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bik5_1</name>
        <name evidence="6" type="ORF">G6M90_00g027440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547843.2">
        <property type="nucleotide sequence ID" value="XM_014692357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3N2"/>
    <dbReference type="GeneID" id="26237287"/>
    <dbReference type="KEGG" id="mbrn:26237287"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="740" mass="80823" checksum="B3FFC0DE8826BBEB" modified="2021-02-10" version="1">MKPEAAPEDGAAAAESATAGLQPYSCLSCRRRRKKCDRTDPCANCRRAGTECVFVPRRPSTRQYSGAGALERVRYLEGVVQQLRAKLESLSGPHEGGDGASSRGHTASPAQPHAAHDADGVPGLHEEDDDEDEDEVTQLQTEFGQLAVGDGRSRYIVSNFWANLTEKVDGAASILEDLAEEEEARREQGDEQPTSILGLGPSLANAGPLHPAPDEFAVYWRLYKENCYPIIRVLHMPTVEPVVLRYQGRAGGDMPAGVEALLFAVYFAAVASLPDEECRAALGGDKRVLVGRYKAGMERALARARLLETDEVVVLQAFAVFLGSLRSYCNLRLMWSLTSIAARLAQNMGLHRDGTHFGLPAFVVESRRRLWWTICTLDARAAEDSGYRTSMHASGWDTQMPRNLDDADLGPGLAHLPASRVGFTEMAFGMVTSRATAAFQTLQSLSPGTVGPCGRLHTADGLARRAAVITGYQDALQRLFVGHDPADPFYWYTALVSCTLLSKMWLVAYFPSLRLATCGGLSAGVRDGLLVRAVTIIESQVLLYTGLPTARWSWFCLSHVQWYAIAYILTELCARGPGELVDRAWRAIDAVLKADGLTRSGGGGDGDDEFGAHSRLGSLHDFEYRLLNRLLRRAREAHRPASAAMPYRVPGPDDLRSAAHRFDHELAFRSAELSPAAAMNHCGAETRDHPPVSPDYLRDQLLASAHDHPFDHLLYGSLQNDVDVAPAHQMPDYPSDKGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z470</accession>
    <name>A0A7D5Z470_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g104280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987684.1">
        <property type="nucleotide sequence ID" value="XM_066131640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z470"/>
    <dbReference type="GeneID" id="26245674"/>
    <dbReference type="KEGG" id="mbrn:26245674"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="279" mass="30927" checksum="B79E99BF4E259543" modified="2021-02-10" version="1">MASTQHNSYSIGHALPQVQHHEWRTAENSAAHLIPHLETSASQNPHLKLLDVGAGSGTITASLAKYMPEGQVTATDISDDILQRAQFHAAKEGVKNISYQRASVYELPFAESSFDVTHAHQVLTHLDAPVDAIREMLRVTKPGGIVSLREADLRMWCFWPEVPALQRFHELNLEQHISNGASGTAGRELLSWVLKAGAKRENVEMSFGTWCFGSDRDRKPWSDSMVERLQSGPVWGKALENGTVKREEVEEMVDAWKTWAATEDAVLGIVNGEAIIRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z473</accession>
    <name>A0A7D5Z473_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phaB</name>
        <name evidence="8" type="ORF">G6M90_00g047840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544900.2">
        <property type="nucleotide sequence ID" value="XM_014689414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z473"/>
    <dbReference type="GeneID" id="26242241"/>
    <dbReference type="KEGG" id="mbrn:26242241"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="279" mass="29476" checksum="C1C5A194AC6D04CF" modified="2021-02-10" version="1">MTVYHLQSVDNDLRGRLALVTGSSGGIGSACAKALASEGCDVVLHYSASKEKSESLASELQNRYPSQVFVTAQADLTDRESTRSLVSRILSDAVVSEKHKAISVLVANAGLGRRIRDVKDIGEQDWDEMMEVNIRSQFVVTRSCVEGMRAQEWGRVILVGSIASRGSGLNGCHYAASKGALSSMGLNLATLLAPEGVTVNVVSPAMIGSTGMIPTPKERTWASDVNVEALKESDPGLAIASSVPVHRLGAPEEVANVVAMFAKTGYMTGQDILLTGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4V6</accession>
    <name>A0A7D5Z4V6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-classical export protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g045630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986171.1">
        <property type="nucleotide sequence ID" value="XM_066130398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4V6"/>
    <dbReference type="GeneID" id="90967721"/>
    <dbReference type="KEGG" id="mbrn:90967721"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6427" checksum="B9BCE5E80883D4F7" modified="2021-02-10" version="1">MPAPTYIISKIADPIFAVFIGISAATMRINREEKAKGYTTQQTIDNGLRRIGLSKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z519</accession>
    <name>A0A7D5Z519_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SRRM1</name>
        <name evidence="4" type="ORF">G6M90_00g098010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131537.1"/>
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    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="314" mass="35051" checksum="C41FEE8D9A1CB1C1" modified="2021-02-10" version="1">MASKVDARLLKSTKFPSEFSQKVDMQKVNLQVMKKWIANKISDILGTEDDVVIELCFNLIEGTRYPDIKSLQIQLTGFLDKDTALFCKDLWMLLLSAQTSPQGVPKELLEAKKLELMQEKRDADKAADDARRRRDDLDRRDRGISDLKERDRRDPITTIADRETNMAATVTDTSQTIARDGEETETVVDIDRDHIRQKNPHVRGHATGAHLVAPLAADPALLHAGELRRQGALEVGSGPDRQEEMHTVQGMTDVAPVLPVNLGLCRRTAVHPLERGGGNNRSHEADRRHVEGAHHHLMVQAVGLDLAVVIKALQ</sequence>
</entry>
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    <accession>A0A7D5Z5L9</accession>
    <name>A0A7D5Z5L9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">G6M90_00g082170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543448.2">
        <property type="nucleotide sequence ID" value="XM_014687962.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5L9"/>
    <dbReference type="GeneID" id="26243625"/>
    <dbReference type="KEGG" id="mbrn:26243625"/>
    <dbReference type="OrthoDB" id="10264507at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="119" mass="13785" checksum="C54F45988633EB4A" modified="2021-02-10" version="1">MSWAAFPRQSARDSTGETKTDLVHLAPPFAVQLVRQKNYGPLESKKYFIPVQGTTGDFVEVVEDDLIQANFQKLNTYKNYKCEVHDKFYEVNIYQKDPVNKHHWRATLARPARDIDLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z623</accession>
    <name>A0A7D5Z623_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g055120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986879.1">
        <property type="nucleotide sequence ID" value="XM_066130594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z623"/>
    <dbReference type="GeneID" id="26246200"/>
    <dbReference type="KEGG" id="mbrn:26246200"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028857995" description="Isochorismatase-like domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="240" mass="26272" checksum="278EF0B5FA8F4652" modified="2021-02-10" version="1">MKMLSLALAGLAAVAAATDDKFRFERLEKNNSMLLVVDHQVGLYNTARDFDPNLFRDQVLAHSALGKVFDIPVVLTTSTQAGPNGPLPREILEMHPNAPLILRGGEVNAWDNEEFRNAVQKANKKQIILAGVTTDVCTSFLALSLREAGYSVWANAEASGTTSALVRDISNDRMTQAGVHVVSLFSIACDLMRDWRHTPGAKEMIPYFDKYFPVWAYIARGHQAAVTNGTVLAGEEKLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6G3</accession>
    <name>A0A7D5Z6G3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase MPS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPS1</name>
        <name evidence="9" type="ORF">G6M90_00g097520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QLI73023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014691103.1"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="538"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1"/>
            <end position="420"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="476"/>
            <end position="504"/>
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            <begin position="1"/>
            <end position="14"/>
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    </feature>
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            <end position="54"/>
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        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
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            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="242"/>
            <end position="254"/>
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            <begin position="255"/>
            <end position="269"/>
        </location>
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            <end position="297"/>
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            <begin position="332"/>
            <end position="355"/>
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            <begin position="383"/>
            <end position="396"/>
        </location>
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        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
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    <sequence length="881" mass="96320" checksum="39458A175C44D6BB" modified="2021-02-10" version="1">MATASPTPMATAGAVRRTSQRQALRRPASRQMVSRSESQAAAAAAATAAAVAPASQSPHQQQYHDDSSEDEIPVPMKLSALTKALLNDDAPEPANKEASPPRTRRRTSALNNNSSSAGVVGAGPQDRRHLRSGSVQPADDKPAKAADTSQNQEASPVRKRVVRLGSNPHSLNQMGPGKRRSTSMSRSTGQKAAVSLPSRTSNNHEKPAEEEQEPLPEPQPEVNTPPHPDRVVRIAAGSSANRSRVGSSGPSSGRSKFDRSVADRSHLEAEYDQLEAPESAVRNSGSHGSASRYPSTRSRPDDVNPQSSMRVKRVGKLSGSFLSGPARRGRRRQSDEEGEGHVDGDHAVPSHEAEHGLQPADEPPEPSVYHEANRDFNSGSPVSGSAARASNRRQASGIELPDLGSSRRSSRGVQFEARRDDHITVPEAMLPKRIEIPSIHDQENEYPITFKRPVKVAADPGVEKPSIRPLHVDLGSAKAASPERKPLASIANNTPHRSAPPPPPKMSVLEAATSTAGAATTTQARQRRNVLRVNGKCYTRLECLGRGGSAKVYRVTAENGKMFALKRVSLENADDSIIKGYRGEIDLLGKLKGVDRVIDLYDHELNSEKQVLTLLMEMGELDLNKLLTSRQSSETAKFDPVFVRFYWKEMLECLQSVHQYEIVHSDLKPANFVLVQGRLKLIDFGIANAIQTEETVNVHRETQVGTPSYMSPESLMDANNPRGGRLPGRPKLVKLGKPSDIWSLGCILYQMVYGVPPFGHIANQMARCQAIINWDHIIEFPSRAVGGVPVPPSLLRTMKRCLNRDLHMRPTCEELLHASDPFLYPAEFNEKALPIDEELLGRIIQSVVTRCRERMPTESEGASVWPQAYWTSIRKAMAGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6L0</accession>
    <name>A0A7D5Z6L0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g106460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131707.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90968217"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028938924" evidence="1">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="82" mass="8915" checksum="056213C5CD9652A8" modified="2021-02-10" version="1">MLAKNSVLLAFATAALAAPQFFKYENEEVLVSVKVPEEETKPSTQAAVVINVMTGSDDPAVWPNCIPNGTKCKFNDKEKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6M2</accession>
    <name>A0A7D5Z6M2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">klp9</name>
        <name evidence="10" type="ORF">G6M90_00g067620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI70527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130857.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246625"/>
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    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="12"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="110"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="830" mass="90802" checksum="961308CBB827CD26" modified="2021-02-10" version="1">MEAPPKPSSHNLFEVYLRLRPPPAGATSTPDRILNIEEPEDKEKSHPSHITLNPPTDRRRAIEKFAFTRVFEDDASQLDVFHCTEIASLAEGVLGPRGGDGTDAVVATLGVTGSGKTHTILGSKSQRGLTQLALDVLFRSIGPNMLESTSLPSVIESLQACDPSESVLSAASCFLESVFADALGHSRGPSRAATPMLVRPSMPRVSFVRSPESSCGAYPKGGLAVQIPGTYPDSAASSPKSVRLVSETEQNRKLKEHQDAGVAASLPKRERESKRHFMSLTATARVKNVTKLGVKGDHGVMSPGPRRNLARPSALPQTPDISGINISCDSSAEYAIVVSMYEVHNDRIYDLLTPATRSAATKEFRRRPLLFKSTELSPDRKVVAGLRKVVCASFKDAIMVLEAGLLERRVAGTGSNSVSSRSHGFFCFEVKKRTRSRRPGPWGGSKLTIVDLAGSERAREAKTQGATLVEAGKINESLMYLGQCLQTQSELSSSTKPNVVPYRQCKLTELLFSNSFPSSSSTAHPHAPRRNPQRGVMIVTADPRGDFNATSQILRYSALAREVTVPRIPSITATILAQAPPTGNPRPVSPVQHHPRPFVPPGSSASYRNHTPPTNVDERATMEIAALEIARMSDEIDQLRVEVDEQLEARMTAEAHLLSMEDRMLDLEAAIRDECATEFEQRLLLELSRFKASLSLEQERNEEHWDRKVDILERGLENAPDDGECDKENVLVEDLTQEVERLRRENAILKRELAGRSPTKRKPLEERDDFSPATAATSSKDGVANLGRKLERMRVSADSLRAASANAAGGSPKKMRKLASTKRWEEAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7U2</accession>
    <name>A0A7D5Z7U2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar segregation protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VAC7</name>
        <name evidence="3" type="ORF">G6M90_00g076830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7U2"/>
    <dbReference type="GeneID" id="26241453"/>
    <dbReference type="KEGG" id="mbrn:26241453"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
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            <begin position="481"/>
            <end position="622"/>
        </location>
    </feature>
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            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
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            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
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        <location>
            <begin position="838"/>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
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        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
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            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
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        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
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            <begin position="315"/>
            <end position="352"/>
        </location>
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        <location>
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        </location>
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            <begin position="508"/>
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            <begin position="536"/>
            <end position="564"/>
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    </feature>
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        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
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        <location>
            <begin position="779"/>
            <end position="794"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI71467.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="859" mass="91571" checksum="9A0C5AC84EEE50E6" modified="2021-02-10" version="1">MEKSSATADGAAGTASAAAVAAAPSSTKTNNTTGPNGPSLPPPNTSTTESQTSKQSSAANSVAHSPAASRDGSPSRQPRGATSSTMQTGSRSRTNSHQETSPTRQLRQGSQDQGAPTRTLSSMTTPNLRPSNRETPIYAPTPQKPSAIPDLKDNPRWPVSPRLRSPPPQLGRPRATTPTRRNEQEAPVISIQRPSPSPHVSDTQSQVLDSDTDDSHAPSGVRTPARGLLETVQEVSHNNSPARPSDSALLEQVKEKLGAPENHSDGALSDGGRTLKSKMSTVNDQYGAESGTIRADSRRPSSVPPPPLVSRQSSAMSGKQTKSKPETGSTQSMTVETETVSSIPQVALTTATKEGGNATLKAKPSTETIKPKKEKKRTARKQPAVSAGTASSKADNFEAKIASAVDEANTSDSEETFVYDSNPPDNTERTNRRFHSRTPSATSMASQVDRPNLRSIYGIMEGTSHGPVAKKSMKFVNTFNGNASDSLTPGDEDGKGSGRSAGGSARGTVRHHHHIGRWGRQPGNGHASLFDTESPFPNAAKSKFSSSNNLNNSRNTSNLSSPRTFLSTRGHLNPKRSTMQMSSNYDLDDTTGADDERTPLLGTVRSSRGGRRRPHTLRQAESQTYTRRSSYLNRFAACLVLTMMLLLVITGAIGFMFATSQPMTDIEIMSIKNVVTSEQVLMFDLTVKAHNPNIVVVTIDHANLEIFAKSEYAGNDSDWRKSPGGSNEIHTRDDPVNDPPKGPGEGDGGDTDSRPNILLGRITEFDSPLTFEGSLFHQGASSSTGEMQLPNPGNGTSGGSERWGHIYQNEFDLIVKGVVKYSLPLSAHIRSATVSGRTTVKPNSANDPSHKPNSTILGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8A1</accession>
    <name>A0A7D5Z8A1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellular nucleic acid-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">byr3_1</name>
        <name evidence="4" type="ORF">G6M90_00g077470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545355.2">
        <property type="nucleotide sequence ID" value="XM_014689869.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8A1"/>
    <dbReference type="GeneID" id="26241388"/>
    <dbReference type="KEGG" id="mbrn:26241388"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000034">
        <property type="entry name" value="Universal minicircle sequence binding protein (UMSBP), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="18792" checksum="48E234BEE843DB39" modified="2021-02-10" version="1">MTANFSQANAANTLRYTGGNPGHQARDCPSKGPAKCYNCGGEGHMSRDCSEPMKENKSCYKCGQPGHISRECPLGGAGGAGGAQSTECYKCGEIGHIARNCSKAGGSYGGSFGGGYGGGGAGKTCYSCGGYGHMSRECVNGMKCYNCGESGHYSRDCPKESSGGEKICYKCQQAGHVQSACPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8H6</accession>
    <name>A0A7D5Z8H6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar protein sorting-associated protein 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">vps53</name>
        <name evidence="10" type="ORF">G6M90_00g059180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544491.2">
        <property type="nucleotide sequence ID" value="XM_014689005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8H6"/>
    <dbReference type="GeneID" id="26242903"/>
    <dbReference type="KEGG" id="mbrn:26242903"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="593"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="802" mass="89502" checksum="BE4215EC1A8C6C20" modified="2021-02-10" version="1">MEHLNMLFSHPSTVSSISQVSQTLKAHQNALSSEINSLELEQAYKPDSSLERMQSAQTELAELFRKIETVRSRAIETEQNITSMTAEIKRLDGTKRNLTLSMTALKRLQMLTTAYEQLRGLAKTRQYRECAGLLQAVIQLMKHFNSYRSIEQIATLSREVSELQRELLEQVCEDFEMTFVKGEVATKRSMLVEACLVIDALGDSAKSRIITWYVNTELREYRQVFRGNDEAGNLDNIGRRYAWFKRMVKTYEDEHAAIFPSHWHVGELLTTAFCDGTRDDFKGILERSMRRGDGGKVDVNLLLRCLQETLDFEQSLEKKFSDGPRASIDTLSSTEEKTHNFNGLVSVAFEPYLSLWVDSQDKQLASLMPKYRNQPLIPADEEFSPQGIIPSAIELFHFYKLTLSQCAKLSTSDRLLDLSKVLSKYLDEYAQQVLLHILQAGGSHGPSLHNAILVLNTADFWYINTGQLEENIKKRIDNDLVPKVDLSSQADAFLGVASAAVLALVHLVELECEGTWREMKNTNWSTMDTAGDQSTYVGELVKHVNTKTEEILGLVGKQQYARAFCDNLVEHMASAYINNIVVCRPISEVGAQQMLVDKYALTKSFGSLLSHHNPSSPTQQAPPSSFVRRVEHSMNRMDPLLKTLQVRPSPPEGLVQAYLIHIGDRSDTNFKKILDLKGIRKQDQSHLIELFGIHRDGSSNEKLVQSSPLLTPLMTTAGMGSGAGIAGMNPGAALTAASGARFDAGFLGERLLSAARDIGNTTQSTEKATINENLRNFGKFFKRDIGGLGARFGKGSADDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8Y2</accession>
    <name>A0A7D5Z8Y2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-dependent monooxygenase OpS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">OpS4_4</name>
        <name evidence="7" type="ORF">G6M90_00g093180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987320.1">
        <property type="nucleotide sequence ID" value="XM_066131431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8Y2"/>
    <dbReference type="GeneID" id="26245429"/>
    <dbReference type="KEGG" id="mbrn:26245429"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="449" mass="49774" checksum="AD009EFF2739A7F3" modified="2021-02-10" version="1">MGSKLIDEQQSDIFDLRFAIVGAGGLASALALAKKGFKDIHIYENASNLGFMGAGIQLAPNLVRILSRLDCWDSVEAKATDVLETSIRDGATDTELAHVRMPDIRKKYGHPHCTGHRASLVGGLYQGCRKMPAIKFHFGCAVTAITSFQPKVEFVVKTREGVEQRIIADTLLAADGVKSITRVALLNQINHASEVEDTGQAAYRVLLPREKMQDDPEMMALLDSNQVTRWIGEKRHWIAYPIQSRTMYNMSSIQPDTNFASEPSMTYMTKGLKDTMLSVFADFCPLIQRMLDLVPDGQVCEWKLRVQKPLPTWVHGSVALVGDACHPTLPHLNQGAAQAVEDAAVLAEVLAKCPGSDLPSLNKSLRVYELIRKERASTLVRWAAESGRILHLGQGKAKEERDRRFANANAGGHHLPDKWASSDVQEYIYSHDCMQEAADQFCRLYQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z944</accession>
    <name>A0A7D5Z944_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g083030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987521.1">
        <property type="nucleotide sequence ID" value="XM_066131214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z944"/>
    <dbReference type="GeneID" id="26243702"/>
    <dbReference type="KEGG" id="mbrn:26243702"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="116"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="492" mass="52136" checksum="821208B25F6D2A35" modified="2021-02-10" version="1">MTRRVLEQRPAQEAPPCREPAAPAPFPRSFYSFSLGTTIRPRPGRRAVSRHAPADDATKKLIYTIVKADLLIPGADEPVPDAALVAEAKLIVWVGKQDAIPAEYTQKCRGTYSVPYLMPGLWDCHAHLLAGGDDEASWPAYMGFVAGQPAAEGARLARLCWEVLQRGYTSVRDLAGHGCEVSRAVDEGAVAGPNIYAAGACISQLAGHGDVFALPAGDVLLNLGAAHVRPGHYASAPSCIAAGEDECRQAVRLQVRRGARCVKVLASGGVMSGGDDPTHAQFSPRELAAVVDEARRLGRSVAAHVHGKPGILAAVEAGVRTVEHASLADDECLALIKRRGVVYVATREAIELLLELGDDLPRVHRDKLRLVAGHHMAAYRAAVAAGVTIALGTDALAALTMARELEWAVEAGLSNLEAIRAATANGPLTVEGQAPRTGQLKAGYEADFIGVTANPVADVRVLQNEENIRWVWKGGRLFKGPGVGPWGEPAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z986</accession>
    <name>A0A7D5Z986_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g065920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540181.1">
        <property type="nucleotide sequence ID" value="XM_014684695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z986"/>
    <dbReference type="GeneID" id="26246990"/>
    <dbReference type="KEGG" id="mbrn:26246990"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="471" mass="51115" checksum="D4201D47FA59D8DD" modified="2021-02-10" version="1">MRRDRDCHSCKSRNIKCDLNRPSCSQCLEANITCGGYPQRVIWAADRSAKDSHAVPLAAPASASGSASSLASPSASSSSSNATKVSKRQRREPKSKLSDGNALSPEQDLIKTPTSDAAAPKSESPVLELRHMPATDRNSFITSLIAFYQHIISSDGSAADHGHYLSSEAVGLISKLHDLMKARIEGRLAGPFAGGDMWDSIDTARHRLAALIGLNEALEAANPFAFLGIAAFAVLEVCDSPFGEWQRHLHGAKSLLDYHCADPPALEQLSHTVTGLTEIVARLVWWDTLGAIARGSKGLIFDDWHRQTLDQSIFQVVGCSADTFDLFSRVAKGEVATDALSCCILAMDQLAKIDMDESAWVLSANVNRCASAIAVLAQLEDTAHDDAQRAMNSAVERACQLISRMTPSSIYYIHVAVSAYLAGMHATSTRQCQTLRAYWHHCNHAGVQRYPDGLAKCEERWRARGLTGRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9P6</accession>
    <name>A0A7D5Z9P6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987256.1">
        <property type="nucleotide sequence ID" value="XM_066130912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9P6"/>
    <dbReference type="GeneID" id="26247176"/>
    <dbReference type="KEGG" id="mbrn:26247176"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="61562" checksum="084C7F7BFF1B7D7C" modified="2021-02-10" version="1">MDDIEALRRKLREAENRALEEQRRREEAENRALQDQHRRQVAEALTAASQPQNLQQYLETCHSLHLAIEVVTNRSLTTQGETTHPTGRIFPRRIIPWDDFAMRQEEIWNDLSISELFCEPAYPSNHQMEYVRSLLKPFSSEVGLRDFERDVVENAVQKLVDRAKTDPLLRVLSPMEHMSLDRDDTGDTAQGSAPKQAPAPKSRRKARGMGNRADHFAPHKLSLDEIITGLEAEVQPERDVINKDSQGFVLTARRLAAAVVTQLFSYMIGKGIQFGYICTGQALVLLHIPNDPSTVYFSVCVPNQDVMDDDETSLRCTAVAQVFAFILQALHARPPPQMWHDAAETLGIWTVEYDDILRDIPPSERKRKEPLAKGVEGADLVCLQHEKDIYDHLQPIQGEYVPICLGIIVLAIPYYYDSGIWVHFMFLSWAGQPILDCVDPAMKAGIATAVAMAYRAVHKLRVLHRDAQPRNILYNTTSRGFMVVDFERAEFHCRRPLVSIEPNLNRKRKRRAVQKQKKNDFARELESAVANALSCVVNLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBF1</accession>
    <name>A0A7D5ZBF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g083130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987371.1">
        <property type="nucleotide sequence ID" value="XM_066131217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBF1"/>
    <dbReference type="GeneID" id="90968068"/>
    <dbReference type="KEGG" id="mbrn:90968068"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="74" mass="8371" checksum="AFADF0691C4B8404" modified="2021-02-10" version="1">MTVVVNRLNAMMVQYKAVGIVPKHLPLFRFDQVGGIGLEGHPTDAEIAAASDEERRRYKEAMKGYYFTEPEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC80</accession>
    <name>A0A7D5ZC80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cut20</name>
        <name evidence="8" type="ORF">G6M90_00g087840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542331.2">
        <property type="nucleotide sequence ID" value="XM_014686845.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC80"/>
    <dbReference type="GeneID" id="26244845"/>
    <dbReference type="KEGG" id="mbrn:26244845"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="274"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="757" mass="84217" checksum="CE1881DF1EE065B8" modified="2021-02-10" version="1">MAQRKQLSLYSETELESKAPVGFPSSCPTLDLSTTWDAVDKNLFIYRPPRQAVSKIHQAGAPGTQSSEVVTVTWKPDGQFLAVGWSDGVVRLMGLETNKAAHHIPVCGGTANISRIGWATCNVASKSPGDLLIQSKDGILTNTTTSDDNLPPNLPQELTFLEVDTALPKISPLPTSSAGADDDATVFTLRTGIEFLFQPPKREEYEQVNVMIVGTDDGKLQLNIYDSFLIGTFPSPMSESLNTPPYMISHAAHPRLSTHALVFAHTQTEPEYLHLVPMDLPFISSSPINLCLLASKLTTLQKLLRYIKQTQLHMQVEWKNTRELPSRFLRSVQGDLEELPSGPRSIVPALYHTVVTGHAYGPVREWLIDSLAERGHKRWDKAVVSGLENLRSLVHENFLPALERCTIILSRLRGLAQFYDDRDDIGYSVTQTNRLLDIIACLGLVGHKILSNVMDELEHFNAFSTWLRFQIDRQASSSTTADELTEKEATMDTSKVLTYIENYLTHSPLDVYFDQVSEEDWQADFDHIEDGVGILPILDAQLKKQESGQGSRKALQHVDFLVSYVTTCSSRIFKDIAEATKRSVRFGKAVKLSIGQPIALMDTLIFHTSGNAGRIYTALASKSYSDEVYIFRSGVDIKNGISSSSQTTSTCIRLPNKKLVDLKFLNDETLALLCTQTDNTSIVTLVPLESDHLQYKAYDSSPGDTPIIELADLQEFAIPPEYAMRPVRMEVHDKTDLRGELPQYEIPLVVGVISNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDN2</accession>
    <name>A0A7D5ZDN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyl-CpG-binding domain protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987740.1">
        <property type="nucleotide sequence ID" value="XM_066131586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDN2"/>
    <dbReference type="GeneID" id="26240641"/>
    <dbReference type="KEGG" id="mbrn:26240641"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39585" checksum="796974499F5330CA" modified="2021-02-10" version="1">MSSSFGASVLSTFDCGEDGTEFLSQLIESPDTPAHETRQLVDTSILANSDDFHYLIECARSIQQSRHLPYENLNGNDLLSFVWLILTSEPTVPDTEETPWAETDRLILLAKELAKDPDIRGPSARQIASYTSGQAAIPVFYKVRERFPSPTELRDPNNAEELFSMIRHLGLAANRLAFIQKYAEVFISNPPAPGKQYKVRNYERRDILPSAMSMESLDTAGDSKCLNPGAADDEANAMAWEIGHMTQGKYTLDSWRIFCRDELLGRAQDWNGKGRQPEFQPEWMRVLPHDKELRAYLRWMWMREGWEWNPETGERQVLRPELEAAVNEGRVEYDNAGGLRILETARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPK1</accession>
    <name>A0A7D5UPK1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g008520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549656.2">
        <property type="nucleotide sequence ID" value="XM_014694170.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPK1"/>
    <dbReference type="GeneID" id="26239100"/>
    <dbReference type="KEGG" id="mbrn:26239100"/>
    <dbReference type="OrthoDB" id="3539644at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="3">
        <location>
            <begin position="546"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="787" mass="85010" checksum="4173B7AC32B75DBD" modified="2021-02-10" version="1">MGHDAASAAGDDHENRDEALSPTDGYFHASESSGAASSSHHVPDRPYQQHPAVTWQQHHQLQRPQRTSSHVPVVPNVLVEDPTLRHESAAKAKEAEEERWINNGASQASPEAAFTPHMGSNVISQGMHHGASASLDTYMGNNQTTTATPASPTVVTSPLHHHRRSVEEDGPLLYTGHSTRLPYSHTPFETAASATSTSLNQPTPQSQTHHQNHLDAPPAYSPSPSSPSAGHSQDYRTFAPPSSGSNNVNPDVNQDTMGIPEEHQALLPRQPESMGGSPNGPPASRWQRVKNAVHSPNTRKNIRTLLGIAVVLSIFFAIFGSISLSSGGSQHSKIPKIIDNDPVKEPGMGGERDLEWRPSGSCRNTPHKFDKSITSLQYGSGFSLDIVQRLERNGYRGGRQPNVSGQLLLRPTKESGGSVEIEIISNDERLRPSTEIHVDDGHQSIEIISPRALDWWDYSGATPCIQMRVTVYVPHNAYLDNLKLDLVHLDVDIIEGLVMGVVDGPTIKTVVGDVNTPRASNIDDDVAPYSVQSRRIIIETVSGNIKGWFPLYDLLQVKSSSGDVEAQVAPKASDKKSGNQATLKVESISGDVKLEEPLTSTVRSGKLGKKIPPRDYQVEIGTTSGGITATVVMTSSAKIGSVSGDLNLNVLPLVTKSSDKTSFSTDTKSGFTNVNIYEAVAMELSDNAKSHVKDFEIRRTGRPALYNFDSKHSSISGDFKLYYPAAWVGKFRAESMSGDISVSGQGVRITRRSRGFGKIVEGEKGDGASFIKMGTVSGAVRLQVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPQ3</accession>
    <name>A0A7D5UPQ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgE-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g020980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548449.1">
        <property type="nucleotide sequence ID" value="XM_014692963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPQ3"/>
    <dbReference type="GeneID" id="26237893"/>
    <dbReference type="KEGG" id="mbrn:26237893"/>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029017786" description="IgE-binding protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22905" checksum="C1F4BA5491F3EAA9" modified="2021-02-10" version="1">MIPTALIVLCLLSLFAEASPVSRGESPVDSAVIIFAILRDTPIHHGLFAANGSAIWIGKDTASYCPPVVEERGECPKGKDTSFWVNDRCGMNVIVPGGQQAYVAPDGTISYTAPHSAYIPPGSIRTGFHLIPTPFDGFWEFVIDSHEFWACPGTPGQGPWQVIIADENSSVPGRDVTDCLKFKAYAKPVKDPVWEYLSTLGPEPIVVQEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQF3</accession>
    <name>A0A7D5UQF3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier protein PET8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g008460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549662.1">
        <property type="nucleotide sequence ID" value="XM_014694176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQF3"/>
    <dbReference type="GeneID" id="26239106"/>
    <dbReference type="KEGG" id="mbrn:26239106"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="86"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="187"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="28906" checksum="CF4902CE2A714393" modified="2021-02-10" version="1">MSNPPPFQSALLAGALAGTTVDLSLFPLDTLKTRLQSSAGFFPSGGFSGIYRGIGSAVVGSAPGAAFFFCTYETAKGFLRARAAVPDAVAHMVAASLGEVAACAVRVPTEVVKQRAQAGLHGGSSRAALAAILSQRSARGLGAVWRELYRGWGITVFREVPFTVIQFPLWEAMKSWRRKGRTAGEDVAAAESAVFGSVAGGISAAATTPLDVLKTRVMLSKDRVSVAEVFGTMVKQEGLRPFFAGIAPRVTWISIGGAIFLGSYQWAINTMRTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQV8</accession>
    <name>A0A7D5UQV8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat-labile enterotoxin IIB, A chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g001450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985757.1">
        <property type="nucleotide sequence ID" value="XM_066129507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQV8"/>
    <dbReference type="GeneID" id="26244300"/>
    <dbReference type="KEGG" id="mbrn:26244300"/>
    <dbReference type="OrthoDB" id="4924915at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00771">
        <property type="entry name" value="ENTEROTOXINA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028960754" description="Heat-labile enterotoxin IIB, A chain" evidence="5">
        <location>
            <begin position="23"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="687" mass="77097" checksum="37485BD0F8687399" modified="2021-02-10" version="1">MRWDSLASAAHLALLAIGPISAFPNGKRDVVGRAPKQPAKEVFRGDFRSPRDVAKDGGFRPQGNYANNNQAFSIYRHMVGEHGREDDSDLSDEDSDEEWTSAFVSVTTSVDTAASYGRWVYRIHATPNMIDPTEGEENQPEIFALGGVPWSQVMGWYELRFENNESVNAEGITANDFTPNPAYQPRYDGYTLTTVEPRGPWRSHDRNYWTQFMNGPNVAPAVAFTGQFPLNFGTYSLDGLPGPSQETQIERPPPTQPEAAALSAEDIVMAAEFLHEHNAPCDVSGVDPQTQYLILEADAGFARSLARLHRERPNDTLPTPFDEADQQIQAIIERLRRGQEPNTCQLVGACSGLKLSQKKRATTPGAVSKLCKKIQKPKRGKNRLSPATQNSEKCVLRSPLKIRVQLSDDTSAGSWDRLFLEMGKNARYERGQPAYLLKESPSAGDVMYLDVDLADAYPDKAVTVEDIKKVRLVSYLDNGKEGSNELELQDITLTGKCAASPRAAEARIKARQWFTSWSSALKLKDWVWKRDCEKFTSLKFEWSLGNKVRAGTWDDLKLGSHRDRRVRAHDVQFATNPSAGDSGGEEIKLKDMYGSASVHVDRVDFFHVYSTTRWPSSGEDEWEFGGIKFRAQCEGFDKAVVLDKFGSDYNWHSRSNGIDLPIAAGDWRWEDENFQKQHPFPREKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR03</accession>
    <name>A0A7D5UR03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-methyltransferase tcpN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tcpN_0</name>
        <name evidence="1" type="ORF">G6M90_00g000360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543030.2">
        <property type="nucleotide sequence ID" value="XM_014687544.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR03"/>
    <dbReference type="GeneID" id="26244403"/>
    <dbReference type="KEGG" id="mbrn:26244403"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="288" mass="31549" checksum="82AB1FCCDF7D733D" modified="2021-02-10" version="1">MESVVSGRSRHPSENERLNVQHALVKSIMGGKLLVAPANLDLPNLRILDSGTAQANWLLDLAAVVPDTARLVGTDIATGQFPPEAQRPSNMTLQTQSIFEPWDTTMVGSFDIVHQRFVLAACRSDEQAQRAVASLVTLAKPGGWIELHEGNMLSIQEGEAHKAMMRFRDIAVAAWASIGQLPDPGVRLAGWLRGAGATQVHALVQTVSIGAAASNALEAEWSTELCLNMLRTMKRMTAGKADFPDEREFDRLEEELRDELQRVGNQWCYYLAYGRRAGAEMGAGEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR30</accession>
    <name>A0A7D5UR30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CYTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g001990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542881.1">
        <property type="nucleotide sequence ID" value="XM_014687395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR30"/>
    <dbReference type="GeneID" id="26244254"/>
    <dbReference type="KEGG" id="mbrn:26244254"/>
    <dbReference type="OrthoDB" id="4573177at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30068" checksum="C4216CB5F5A4C1B3" modified="2021-02-10" version="1">MLSTVVTEAPAANMTPDFEVRLQLDPDRVLHSNHQLMDLVRDNFSVKDTVKMNVQFLDKCSNEIFKAGWNVRLRVVQPKPEIELTYKKRYDIAGGNIEAALAKANQDGFNSKSDKYEAQVEWGYKKQTLSVSRGKKVRYSGDGGTDLPGTAASRDMLVDEAPGKFDNYKGKKWGTKALKEAVVFGPVHATRAIGSWRDHKLYIEVWPIRSADGSGWQYFVEASFKAGRRDEAEAARGTLLKELQDKGWFLPEDALKTSIIMERYACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR56</accession>
    <name>A0A7D5UR56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U3 small nucleolar RNA-associated protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">utp4</name>
        <name evidence="3" type="ORF">G6M90_00g025420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548041.1">
        <property type="nucleotide sequence ID" value="XM_014692555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR56"/>
    <dbReference type="GeneID" id="26237485"/>
    <dbReference type="KEGG" id="mbrn:26237485"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="886" mass="97913" checksum="B5AF1A4DB18285FB" modified="2021-02-10" version="1">MDVHRCRFVPYRPSAINAVAFSHPKTRTAKQNAVARLAVGRANGDIEIWNPSSGTWLQELVIRGGKDRSVDGLVWVNEPDQDLGDGHVAIGKSRLFSIGYTSTVTEWDLEKGKPKRHASGQHGDIWCIAAQPQSDKPQVTGGFQEAQNSKKLIAGTIDGELVMYSLEDDDLRFQRVLVKSPTKKAQMVSITFQSRKVVIVGCSDSTIRAYDITKGHMLRRMTLGSDLLGGSKDIIVWSVKCLPNGNIVSGDSTGQICIWDGKTYTQAQRIQSHKSDVLSLATSADGTAIISGGMDRRTMLYKQNSGAGQRWSKVWGRRYHDHDVKAMASFEHGRISVVVSGGPDASLMVVPLKEMGRENHRMMSNLPQQPPVTSAPRARFIISWWEREVHVWVLRKSAADLLQSGEELVDINQNRKLLKTIVVKGDSNIASATINPDGTLLFVSTATDVKAFRLQHEDPAKPSDVKLSSLELPVRLSQLGATQVKLSPDGRWLLVVQEGSRVLMAQIQTEHTSTETAEAPIRLQRLSRLRRQIPRYILNGGLGSYDRSITQITFSADSKMVAVADLAGYIDTWALRNHDQDLQTGDEMETLDDAASASSDNDSSDEEDEGASNMQDRWVRNPNAKLLPKLPSSPVVLSFSDYVPESESSLGAEKDGVDDYILAVVTSSWNVLAFNPRHGALTSWSRRHPRKALPGPVRDLLDLPKGILWQGSRMWVYGVSFLLMLDMGQDLPRVPEAEGGDSQLTQGTKRKRVGQTTGAGGKMERENLAPHQVRKHGADEQWEDIDVVKAPEVGDSDSDEDMVDADGELSKLRSTTISGKTALQSTGSTTVEAKKWWITYKYRPILGVVPIDTPGQDVEVALVERPTWDVETPERYFAGEEWDRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR93</accession>
    <name>A0A7D5UR93_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g017710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985823.1">
        <property type="nucleotide sequence ID" value="XM_066129804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR93"/>
    <dbReference type="GeneID" id="90967470"/>
    <dbReference type="KEGG" id="mbrn:90967470"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028952093" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="121" mass="13785" checksum="040E66E2FEF2DF7C" modified="2021-02-10" version="1">MKHIELILATFAGLAFAAPQRVLTAEEWVGDRVITQQRVLEEFRGRNIICDDEEENNRINCEIGFVSIGIEEKSHDGLSPLCEKKGGCKYCRIESGFRNAQHFMCAYKSSNKDEPIFFPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URC7</accession>
    <name>A0A7D5URC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ARL2</name>
        <name evidence="18" type="ORF">G6M90_00g015980</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548930.1">
        <property type="nucleotide sequence ID" value="XM_014693444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URC7"/>
    <dbReference type="GeneID" id="26238374"/>
    <dbReference type="KEGG" id="mbrn:26238374"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI65035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="181" mass="20778" checksum="2A6A38B11BCF78BD" modified="2021-02-10" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKKIMGEDVNTVSPTLGFIIKTIDYDGYKLNIWDVGGQKTLRSYWRNYFEKTDALIWVVDATDRLRIDDCRDELHGLLLEERLSGASLLILANKTDVEGCMDEQEIGKALRLDEIRTHQWNILRCSAMTGENLQEGLAWVVADAKKRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USD7</accession>
    <name>A0A7D5USD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g026230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547960.1">
        <property type="nucleotide sequence ID" value="XM_014692474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USD7"/>
    <dbReference type="GeneID" id="26237404"/>
    <dbReference type="KEGG" id="mbrn:26237404"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="528" mass="55153" checksum="6AF4F8B53A555864" modified="2021-02-10" version="1">MDLNDLKSTVSNLTLYDLKAGFRKAQNAVMNYTEMEAKVREATNNEPWGASSTLMQEIANGTFNYQTLNEIMPMIYRRFTEKAAEEWRQIYKALQLLEFLIKHGSERVVDDARGHITLLKMLRQFHFIDQNGKDQGLNVRNRAKELAELLGDVERIRSERKKARATKNKYTGVEGGMTFGGGFSGGSGSRYGGFGSESGNYGGYSGGVYGDGGGFGGQHDGYRESGGGGSSGAGRSDGFEEYDEFNEDERPSRASRKSDHTSTKKPAAEPAKKKEPEVDLFSFDDPVQSSSSATPAATQSSGLAVLAGPSSGNVGADDDDDFDDFQSATPATQPIVQPLTTPLTSTATSTAQFAAPQPVSAPQTANLSQMVNTSSISPGPNSSATHGANYSAFAVPMTQNQPPKPTGFQPAGPNYFSGVPSQAPNPAPTNMSAMGNMASTGPTTMANMKPVTSPGSKPAGASGGDAFGALWGKASSSIKKTDKSASGPAMGQLAKEKSSAGIWGAPAVSSQPGSAAGNSGSASGDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USK8</accession>
    <name>A0A7D5USK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g002160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542865.1">
        <property type="nucleotide sequence ID" value="XM_014687379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USK8"/>
    <dbReference type="GeneID" id="26244238"/>
    <dbReference type="KEGG" id="mbrn:26244238"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029037310" description="Hydrophobin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="102" mass="10523" checksum="68345B7C3BD53BA3" modified="2021-02-10" version="1">MSLFKILVAAATVATALAAPHEHKKPHPSYGDANAQCGNHQKLSCCNRGDSGGVLDGLLGGNCQPINILALLPIQNQCTNQVACCTGNSNGLINLPCTNVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT54</accession>
    <name>A0A7D5UT54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mrpl19</name>
        <name evidence="11" type="ORF">G6M90_00g021800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986037.1">
        <property type="nucleotide sequence ID" value="XM_066129881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT54"/>
    <dbReference type="GeneID" id="90967491"/>
    <dbReference type="KEGG" id="mbrn:90967491"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="157" mass="16758" checksum="EF65B0060890A4AE" modified="2021-02-10" version="1">MSKAKGATGAVDQVVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHITPGTPMPCRVTVRPDRSFHFDLRTPQTSWLLLNAVEAPRNKKGNRKGASKPGHETVGTISLKHVYEIAKIKQSELRLSGLSLEGLCRSIIYQARSIGINVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT87</accession>
    <name>A0A7D5UT87_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539477.2">
        <property type="nucleotide sequence ID" value="XM_014683991.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT87"/>
    <dbReference type="GeneID" id="26247751"/>
    <dbReference type="KEGG" id="mbrn:26247751"/>
    <dbReference type="OrthoDB" id="4954733at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="67313" checksum="40188F4A70A6CEB8" modified="2021-02-10" version="1">MAQTARACSFLDRPWPLDDVISIPSDSESETDSDAEVMGQDVPRVHFTHDQHLDDSLPSISAIVASMVNVGHGPTKDVSEQLQTQLQGAMAISSLGSSTQDLCLGGEGESSDSSALNSPRGVIFVSRALDGPGIAADSNELVSPAIQQHNDGVNSVLPTSIPTPGVVSVASERRSAQSAPVLPPRDEALQEENVEPPFQPCLASTTIPVQHSQSQNCIVVSSNQCSQIHNVNVDHGRISGMVSRSDDELHSVARPASAQTTPSGCSRPVSRRGGLMEGVQKHQTADNTLPMDSRLSSSPTGQGWDEECQTSISANHTVSQPEEMEKRSSSRRGFRKAYNLRRLPVKRQLTAEQKDGGSNEKLVPQRKLRKLICPQPKKLGSQQGSGPRRNRKAHFLRKNTTKSSSNASVANAKRPAHSGVAGYEAWPLGNPVLKCTKQNGTVMFQLQFTSDTLWNTLAAQNDPIPKDGQAPNKVEDRRLRARKEQSNQQHAENIAQQSIQAAYPSVCPDIYRMDCLLARWRRHTFLVKWSDATTTWEPRGHIIDKGLLNRFEASWQGFDAGVDVLGARLRAGKLQRLLHWHGRPSKEDTWVRSELLSPQLMRRIQSNDIYGAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTE7</accession>
    <name>A0A7D5UTE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATG12</name>
        <name evidence="12" type="ORF">G6M90_00g037120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Preautophagosomal structure membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986168.1">
        <property type="nucleotide sequence ID" value="XM_066130215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTE7"/>
    <dbReference type="GeneID" id="90967648"/>
    <dbReference type="KEGG" id="mbrn:90967648"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000148">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5 10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="158" mass="16938" checksum="D5332466B1E04317" modified="2021-02-10" version="1">MARPYEPGPSTSLSTNTPSQTPSSPVPEEDDDSGAASPELPLTMTASVMLADLPRDATAALASVGGFPQEKVVVKFKPVGAAPSLAQELCKISATRKFEEVVRYLRRKLRCKDTDSVFLYVNSAFAPSLDEVVGNLHQCFKNGQDQLIVAYSMTPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU45</accession>
    <name>A0A7D5UU45_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L34-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL34B</name>
        <name evidence="4" type="ORF">G6M90_00g042060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547545.1">
        <property type="nucleotide sequence ID" value="XM_014692059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU45"/>
    <dbReference type="GeneID" id="26240108"/>
    <dbReference type="KEGG" id="mbrn:26240108"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13242" checksum="249BB0E17E46E264" modified="2021-02-10" version="1">MATQRVTYRRRNGYNTRSNRTRVVKTPGGELRLLHIKKRGTVPKCGDCGSKLSGIPALRPREYSQISKPQKTVQRAYGGSRCGGCVRDRIVRAFLIEEQKIVKKVLKEQEQSQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUI5</accession>
    <name>A0A7D5UUI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-serine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DSD1</name>
        <name evidence="4" type="ORF">G6M90_00g040000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986321.1">
        <property type="nucleotide sequence ID" value="XM_066130264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUI5"/>
    <dbReference type="GeneID" id="26239913"/>
    <dbReference type="KEGG" id="mbrn:26239913"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="330"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="474" mass="50970" checksum="DD4D0237474E6DC8" modified="2021-02-10" version="1">MSSIELYPTSPKHILAQFIGKSIRDVPTPAAVINVAAVRRNCERMLQTCVKLGLDWRAHTIEITEFQVGTDAARPVNLIVSTLAEAEFLLPRLKEYKSQGRKVNVLYGLPIPQNALSRLAAVAQVLGEGSVSVLLDDPAQIPIVSKFQGLSGVVPHAHIKIDMGGKRAGVEAQSARFLELADAALEAHGQGKIRLSGLYSHAGHSYGGDSRAAAIKMMRAELSAMLEGADRLTSRAAEKSMAGLPPLVLSAGASPTALAVQNLITTAEEGQDNVPVQLKAEVEALSDMFATVRSKGHLVEIHAGVYPTLDLQQLAAHSISASRLSWGDIALTVLAEVHSNYPGRGANGTPEALIGSGGIALARESCKAYEGMAMLSPWGRKGVGLPTCDVEDFRGWMVGRFSQEHGILTWRSGNTKSEPVQPDQELPGVGDKVRLWPNHACITSSHFGWYFVVDEDEAGKEDEIVDIWVRCRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUV7</accession>
    <name>A0A7D5UUV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">vps27</name>
        <name evidence="17" type="ORF">G6M90_00g038040</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547163.1">
        <property type="nucleotide sequence ID" value="XM_014691677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUV7"/>
    <dbReference type="GeneID" id="26239726"/>
    <dbReference type="KEGG" id="mbrn:26239726"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000031">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="649"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI67398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="743" mass="82161" checksum="58A1EC22A64E3A0C" modified="2021-02-10" version="1">MMSWWSSSANTALDEQIEKATSSSLEDIALNLEISDIIRSKTVAPKEAMRSLKKRIGNKNPNTQLSALNLTDTCVKNGGSHFLVEVASREFMDNLVSLLQAVGAVAVNADVKTKILELVQQWAAATEGRHDLSYINEVYRTLQREGYQFPPRVTVASSMIDSSAPPEWADSDVCMRCRTAFTFTNRKHHCRNCGNCFDQQCSSKTIPLPHLGIHAPVRVDDGCYAKLTGKGYRELGPPDRSPTYPHKTRSTSAMQPRNARVDDGFDEDLKKALAMSLEDVKNNSRGYVEPAENRARATKDSSKLEEEEDTDLKAAIAASLADMEEQKKRHAAALKEQTSNRPTSSSSTPFVLPKNDYELTPVEAENINLFATLVDRLQTQPPGTILREPQIQELYDSIGTLRPKLARTYGETMSKHDTLLDLHAKLSTVVRYYDRMLEERLSKAYSQQNLGGYSLPPPRQPTSAYPSVPSQAHANPGVAESFYTGQVPPPSFQVPPAQSYQQQQVPPQATPQPQFASYSQPSEPHSGQYALPQRTSSWQTRAPSVPQDPYHPQQAPVVEPAQGIQTPQQAPASPSTERRGSYYFGTQQQHSVQVPSGPSAPGPAPGSTPSPYPSLQHSMQYQQPASTTAPSQATPIQSHAQPAQAGRRPSQTQTQAQPQSQQVLVPQQQQQQQQQQPTAQQQPAQQQFWHQPGAHQSTEQTPQQQPEAPQSWAYTGYAQPTFPSVPQHEPMKKPVQEEALIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV00</accession>
    <name>A0A7D5UV00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">nuo78</name>
        <name evidence="16" type="ORF">G6M90_00g049300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986472.1">
        <property type="nucleotide sequence ID" value="XM_066130465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV00"/>
    <dbReference type="GeneID" id="26242380"/>
    <dbReference type="KEGG" id="mbrn:26242380"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="16" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="15">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="249"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI67934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="742" mass="81295" checksum="552672353BD48BE7" modified="2021-02-10" version="1">MLRQSLARSAWRTSRRTVNASRTFATTPRRQAEVELTVDGKKVSIEAGSALIQACEKAGVTIPRYCYHEKLMIAGNCRMCLVEVEKAPKPVASCAWPVQPGMVVKTNSPITHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGADRGRFHEIGGKRAVEDKNIGPLIKTSMNRCIHCTRCVRFANDIAGAPELGSTGRGNDLQIGTYLEQSLDSELSGNVIDLCPVGALTSKPYAFRARPWELKHTESIDVLDGLGSNIRVDSRGLEVMRITPRLNDDVNEEWINDKTRFACDGLKTQRLTMPLIRREGKFEPADWEEALAEVARAWAAKKPQGNEFKIISGALTEVESLVVAKDMANKLGSDNLALDTPTGSQPIAHGVDVRSNYLFNSRIWGIEEADCILIVGSNPRHEAAVLNARIRKQWLRSDLEIGVVGETWDSTFEFENLGTDHAALKKALAGPFGKKLQAAKRPMIIVGSGVTDHADAKAFYETVGAFVEKNAANFTTPEWDGYNVLQREASRAGAFEVGFTTPSAEVAQTKPKFVWLLGADEFNEADIPQDAFVVYQGHHGDRGAQIADIILPGAAYTEKAGTYINTEGRVQTTRAATSLPGASRTDWKILRAASEFLDVSLPYDDLAAVRDRMIEVSPALAAYDIVEPVALRQLSKVQLVDQNKGSKATGEPLKKVIDNFYFTDVISRSSPTMARCSASKATGDPRTNFMAPGMEEDKPMGQVAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV60</accession>
    <name>A0A7D5UV60_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein MON2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mon2</name>
        <name evidence="9" type="ORF">G6M90_00g036960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986408.1">
        <property type="nucleotide sequence ID" value="XM_066130199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="90967632"/>
    <dbReference type="KEGG" id="mbrn:90967632"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="1363"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1720" mass="188068" checksum="0342BF088B42539D" modified="2021-02-10" version="1">MTTQLLANELANLIHESKRKHNDLRQAAEKSLEELKQLGSVSEQAAPELLSQKPNFVNPFIIACGTKNAKFTAIAIVCLQRLIVAKALPKSKLNQVLEALMQASSAGLDVQLKILQALPSLLQNYSAELNGNLLVTALNICFILQSSKNAIVNNTSAATLQQLVVSVFDKVVSEDKNGPDAPVVGEAASADGTVQLRAAALDAYRIFNDLCLMTENQRPEFLRFSSLPQTFGLELIEPVITNHASVFTTHAEQAHILRVRVMPLIVSALKGRPSFATTVRLVRILYTMLRRHIDILPKECGDALEILTHLLDQDSALWKRALCMEVFRSIFSDYVLVRKIFSLYDDKKGERNIIKTLAATFVRLSTEKPAVIGLGHQSTMPMSDPSTNLAQSTDHAMLEAGMSGIISSSINSEASNTGISTQWSSIRVPCIDQLDKTDPPSIPESYVYSLILSCLSSLSDGLAKFILPLTVPSESRSRRKASKHDSGRDSPASSDLPEKKLAGLERTASFKKNPVPVNPLQLKDHPMYPDIKICAAIVDECWPAILATFSTFLYASLDSEYYHSLVRSFQRFAHVSGLLQLTTPRDAFLSTLGKSAVPPNLLTACMNSGQPKSVAPSTPSDTANTLFSNARGLLSVETLTPASPSAEKQRNASFDAAAVSLNTRNLLCLRALLNLGIALGPTLGSAWGIIFETLQQADFVLFATGKAPGRTPSIGRGAEHGGDSDSLMANFNNEIRSVETAASRLIESTVDFPNAPFVEVVEAVCNLLEQNLPEKPEAGDSASPSPIESSQKQLGHGHRRVLSFSTTVSASPNQEFLFALAKLGEIANVNLERLLMNNPAASGWNILTNEIIHALDSPVLGAHVRVKAAETLSRFILEAATATTSIPKDSRGPVQLRLLSSLRDALTTLNQNARSASVASVATDIEVHRIILEGLKSLIEGCGESLVSGWDIAFDIIGSGFVTSNAIQERRRGPEAGLLSTRSPKLTRSAFGSLQLICSDFLSSLPNSCFLILVDTLYKFCSQDDDLNIALTTVTFFWVLSDFLSAKENSLEIRADLLNGSDESELERKAADHTQKGSDAALWMLLLLRLATVASDERLDLRNSAIQTLLRIFDANGGRLNPEAWSICIKSVIFKLLCSLEEELDAASNDDVNERDKVDWHGTAVVVLDGISGLLANHIDVLTAHPSFNQLWRELLGHFATLLDFKVLEINTAAFKALSHVLSQTGDNKKPIFNKMTVEFAWDLWSRGIPTSKAVGDKAEDNQNCLVAYVAALRDVYNLIQEDLTVETVRRMLTLLRQTVEEASVSTHVSDIEHATSLQTQTLAAVQMIRTDVEGVISAVIKQVSEFVTLAYKRELYVSGSKRTYVAMSKASMKLVETLILNHASEEDIYNSGAFSDALSALHKPIALKYDFPISTKSVQPWRLATSSVLSVLEATLPKIRALGIPSNTVREIWVAVVGVADGILSAECDESADGASFDEDETFDISSFRSLRALIIPSLGADDIPDKTRKSYAESLFKNSIIHNFTHTEQEFPDKEDKYGLHSLYAPRPGRTVAIPPTQRRRMAYVAFDELFSLVSAQDPLESTASEPMKQKSRKNKQVEQEEMVSTLRNRIASIAAPFLILRCALTIRAYVADQPLRGQMPQPLSQRKELVWTLTKLVELESRGEAIPSLEKARGERRKHLLRLYPLLVRALGVGGDDTILRLLGEALEAVGSELGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVB6</accession>
    <name>A0A7D5UVB6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RNA14</name>
        <name evidence="7" type="ORF">G6M90_00g043900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547725.1">
        <property type="nucleotide sequence ID" value="XM_014692239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVB6"/>
    <dbReference type="GeneID" id="26240288"/>
    <dbReference type="KEGG" id="mbrn:26240288"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="151"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="894"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="985" mass="110382" checksum="BF94E24F81E7DDF8" modified="2021-02-10" version="1">MATEDAAWEGEGSGVEYDPLAQPSAGLDQPEETSEAVSEAAEPIDENEEDQDDGGEYDPESVGFDSVSHIPDKSASGTPSQRPANKPKMSGGFLVEVSDDEEDDNQDAPSGARNSAAANANQTSNGTTPLPIAGALPNAPLGLAGVNPVVLLEARIQEDPRGDMDAWINLMADHKRRGRLDELRLLYNRFLEVFPQAADIWVEWIEMELNLDNFVDAEQLFGRCLMSVPNVKLWTLYLNYIRRRNDLTNDPTGQARRTVTQSYEFVIDTIGFDRDSGNIWQDYVQFIKNGPGQVGGTGWQDQQKMDQLRKAYHRAIAVPMSSVNTLWKEYDQFEMGLNKVTGRKFIQERSPGYMSAKSANIALDNITRNLKRENLPRLPPAQGFDGHEEFHAQVEMWKKWIAWELEDPLVLKDDEPKAYKQRILYCYKQALMALRFWPEVWVNAAAWCFEADIRENEKVQGTEMLLQGISANPESVLLAFKHADHIEANYPEKEEEKSEYAKAVRKPYDAVLDTLYKMGDKVKEREKLEVNTLKQAAANEPAVQESIEEDDDDDDDEEKKVRKSPTEERIAAIQQAYAAESHLLSKTISYVWIAMARAMRRIQGKGNQTEGGLRKVFTDARQKGRLTSDVYVAVALLESVVYKDPVGAKIFERGARLFPNDAGFMIEYLKYLHSKDDTTNARVVFETCVNRLVSKPETLQKAKQLYAYFHKYESQYGELSQISKLEARMAELFPEDPKLSYFTSRYSTETFDPVAAPIIISKAVQMRPKQLIPAIEQPISTRESIPPSRQEQSPRPQFIRATASPKRPFGIEDEDLNPPKRIARGVSPLKGAAGRRLDQQRRNQTSALPRDVTFLLSLLPPAPTYDETRLNPTIMVSLLRDTQLPDYASWKAKTGGQYRITSGNHSRQASGDFGNRPTSPYGRMAAASGAYRNSPLRTESGNAFAANPYAPPPDASGATASSWQPPSAGAYGIPPPAGQYGGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVG6</accession>
    <name>A0A7D5UVG6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g031100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539630.1">
        <property type="nucleotide sequence ID" value="XM_014684144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVG6"/>
    <dbReference type="GeneID" id="26247541"/>
    <dbReference type="KEGG" id="mbrn:26247541"/>
    <dbReference type="OrthoDB" id="4939891at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028841742" evidence="2">
        <location>
            <begin position="26"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="700" mass="75689" checksum="3593BFD6841246DD" modified="2021-02-10" version="1">MASLRWTKWLVLLVHVLWASNIVAALPPPTYVYHVTSKKPNFMGRGGLPLQRERPRVWGQGLSDYINTGMRTANGRLLYAPLGYQEVRQALRAWADPTSSYDQLLNIAVGGWPYLYRIRPGPSTVNGPQDGSFYQTTGWPTDQIEWYSPLPDISGSPPSQQAIHDMSDEALDQYIGRLKWAVVKSHIDHCMRVAAAATRPVLRNNDPNEQRRRIDEIVNAALEGCLCCSTHNPNPGPPPTGDQAAHPGPSTRGDCERKSAEIVKGLTPDPDPARWEEVAWQLVNVCDPSQSEEPVAGPSGLQQRCREAVDKKLKPVIEKSEAQRRPVPEVIAQAQQAICSPSASDQAPESSSDEPPPKKSKDATERCNRDVSNVLAVFNDVGPGQEQGIIDYLVGSDHAPPRDLCFSAGVYEYFSGFPWDMLDDQGQDEAALPAEPEQQQPGQEPQQEQDQDEQLGVQQWPDFLNLVLQRFHVDERRLVVYLDQNDGLSSLQQEHAPIYSLLQQTFPSLLGVLRQIAEAGLTFGSCLPGPPSSPKARATQGKKDELCAKVLAAIGESAKAPGSKQKENDKAPSTSPSTPPSAPQDNTSPSALKTIAAIGVPLAGAGLGAFAASAAGEGLLASTAASLGIGAAVGTAEGVEGAVSTVVYSMPQRVGQILTRALTRVSRLGHRLSNPLLRRITSDAVRAATRRAAERIPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVM3</accession>
    <name>A0A7D5UVM3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g048420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544957.2">
        <property type="nucleotide sequence ID" value="XM_014689471.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVM3"/>
    <dbReference type="GeneID" id="26242298"/>
    <dbReference type="KEGG" id="mbrn:26242298"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="141"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="421" mass="48361" checksum="C7719439FAC6F3D3" modified="2021-02-10" version="1">MPEFAENDSPESNAPTPEIAAGFKNDEKQPANSSRFVHPSGKSGHGLGMQILRGIAFTVYFTFCCFAIVVTQTIGAPLYFINREWFYAYMAMTKQSFALTITVMTHIWGPALVRISGDESVAGQILATPGGGVEFKFPERMVMIANHQIYTDWLYLWWVGYANRPGMHGHIYIILKESLKYIPFIGTGMMFYGFIYMSRKMATDQPRLAYRLNKLKQKKIDPSGRAYFDPMWLLLFPEGTNLSRNGRKKSSQWAEKNGLKDPDHVMLPRSTGIFFCLNELKDTVDYVYDCTVAYEGIPRGKYGEEIFGLASTYFQGRPPKSVNLYWRRFRLADIPLNDQKEFDIWLRDQWYKKDALMEEYLKKGRFPALTGGKTEYVETEVRTRHPWEILQVFTVMGTAGLLWHNVRKFLSTIAAKVGTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVY7</accession>
    <name>A0A7D5UVY7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g049010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986592.1">
        <property type="nucleotide sequence ID" value="XM_066130456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVY7"/>
    <dbReference type="GeneID" id="26242353"/>
    <dbReference type="KEGG" id="mbrn:26242353"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113085" checksum="402F5E43119DFE6B" modified="2021-02-10" version="1">MISDQESAAAMVPAAENNSARPSAVVETPEGNNPGVDGYDVGLMDDLLSALSSIKAPGSFASFGVLPQPPPAGLFVDDVGDITMPLSEVQARQLIAKARQAPYGKGSATIVDTAVRNTWELDSGQFRFQSPHWPGFMRHLCAQVALNLGINAPITAQIYKMLIYEKGAMFKAHTDTEKIPGMFGTLVVCLPSAHQGGEVVLKHCGQKKVFKTSEAPQSFASWYSDVSHEVLPVTSGFRWVLTYNLALHLTGPGPSAGLPQFETGALRRTLKRWLSEPKESRETNCVYHVLDHDYTEANISLKALKTRDLAQVHSLKEISGELAVDVFLALLEKEEMGSCEHDPYEDRYDGFRRYNRSYYDDDDGYDDYNDDESGYHHLEEVFETKYAVKTLVDLQGRVVATRLRLDEQDILQEDCFEDLEAEEEYEGPNGDALAAVIVPRDSLLSFFDTYDMNRYCSPYHNFKTQVRYLARACLQPQPPKSFINALVILSQQAWNIRRTTIGGFGAQEPWIDGDGIRDVLTAAIQHGKYNFFQEAAGHHEGLLPPEFFVWMRQWLLTGDSNTNERFNVIQSGISAAISSYPYFADQFTAITRLVSMSSDDLTPDTAATPDYILDWARGKLRSCMDVCASESLGREDGPAMVDLALFFNDPPAFMSQIISPTIGQRHDAAAFFLAFLARLRQQSKNGILAMGNAIQFYQTKARSFITLADFTQMRGDAGGQAIPTRITPHNCEQAQKLDRRTAISYEVLADFFSAIIQSSTEADDLVTLFVSKLVVKAQQLPALEFHALWLPFLRRLIPILVSNTIPLDNPYCQQLFSALLHAYVNKYVGHKPAENTSLIRPGVRCQCSDCQWLNRFLAGTERVGRFSINKKRRMHLHQQLDSGGVDCTHETWRSGSPQTLVVTKTFRHNEKRLLDWKSRLMLAKEQIRKFEPLHLSLLLGPNYLTIVNMEHLSAAPERAQVQSPAVVSGSSRATDQPRGPLQAISSARLPPSPVAGVKRKLPPTEIDIIDLTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW49</accession>
    <name>A0A7D5UW49_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HET-E1_4</name>
        <name evidence="3" type="ORF">G6M90_00g034100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543337.1">
        <property type="nucleotide sequence ID" value="XM_014687851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW49"/>
    <dbReference type="GeneID" id="26244138"/>
    <dbReference type="KEGG" id="mbrn:26244138"/>
    <dbReference type="OrthoDB" id="4955925at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="704" mass="78425" checksum="FA37509B679A6384" modified="2021-02-10" version="1">MRLLNVDSLQLKYFVGEPGHGVPGYAILSHVWGDDEISFQEMTENVYPSTPASRKGLQKILGFCDKAKSDGHSWVWIDTCCIDKSSSAELSEAINSMFNWYRNAAACYAYLFDVTSDEDPAGPQSAFRSSKWFTRGWTLQELLAPFEVAFLAMDWRELGAKSDLARIIAEITRIDQQVLSTCVWDDVSIAAIMSWAANRRTTRVEDEAYCLTGLFNVNMPLIYGEGRNAFYNLQLEIIKSSDDQSIFAWTCEPEGPSTLSLYEQDARPLGMLATSPRAFAKCSAIVDTYLHTDHDISFDIEKQFVRLVAATMQLCREVKVESEKQLIPVSFVVPTAAHSDPDGAVISMADVIKSWPRQIPWGHVHIAVLRCTDDEGHIVILMEKKSDGKYERIGSHHFPWLRALVTENKKSNQTMHIRARAKQHVSKGNRDSLRGSHYGGNGAVVKTIPGSGYMISHSRPANFTPVQGKIMSYVDMNLVGSSIKKAIGVVTPLVLFFRHARSAEHSSFAIRFDRVGPYGSYLYKISFRVGVTVWEDDGSDKQNPQNDKNGETAQSPMFPPDSPQVSFPISSDCVLRLRYRRTAPMFEDFVNVSIETPLPWQPVLEDPLAAWAVFFAHNFGRNAENLAQFAPQDRVTRTKTLCHLEDQQDQIHTSTTRAGLSEPKRSMSKSPPLAASLPGSADVKSDLRGATLSADCAVSDTLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW59</accession>
    <name>A0A7D5UW59_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g040240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986555.1">
        <property type="nucleotide sequence ID" value="XM_066130267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW59"/>
    <dbReference type="GeneID" id="26239936"/>
    <dbReference type="KEGG" id="mbrn:26239936"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="35238" checksum="D21862BF9B99B963" modified="2021-02-10" version="1">MFATQQYLEAVDAGRKRFRDDEEIANAAAGFGEHRNKRIQSLPLRNPPRAGQHSPSPSVVPLNASPACAGSRPHAEPFQSASHQGGPLQQDAEMDMMDVTISSPPDHDEAAQPPALLLNRSTGRMPTPIQPSFAAQVKGQYSGWAATVQTQTTPNGVANLGHHVMGIAQDQTVPRAMTGGPDWQTLQNHRRLPSPISEMGDPIMHDGSGIPTCTMMDSEEQFGQFGQPSPVHGSMSGQPSPLHAMEHPNAMMDADCHHLLQHGESDTDPSSPSPNRKGHQRSKHTVNSWTWQPGMKKSFSIGYRSDCEKCRLKVPGHFNHIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWC1</accession>
    <name>A0A7D5UWC1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Collagen-like protein Mcl1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g051670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539851.1">
        <property type="nucleotide sequence ID" value="XM_014684365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWC1"/>
    <dbReference type="GeneID" id="26247406"/>
    <dbReference type="KEGG" id="mbrn:26247406"/>
    <dbReference type="OrthoDB" id="4941449at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028816280" description="Collagen-like protein Mcl1" evidence="2">
        <location>
            <begin position="20"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="57330" checksum="315C8591CAED7BF6" modified="2021-02-10" version="1">MRELSSVLALSGLLALASAQDPAALLNSVCFPSGQLKNTIPYPCPGIANAKQQCNQFLPGPNASPDQIKKHRDCLCFDEKIIQFEKGCTACKKTHAFLSKRGEGYWNGILDRVYSDYCQAENPTAAYDASWASASQAAGPIPTGGPDDVLTNYAKDLPADEKTKVELYWKGTTEEKRPSATATPTSVSTSAAATPTLVDDDDEWCDDEETTSASAGSAAATTASPNTAVSGSTQPTPVLNDDWITASAKEDPSASTVRPPQPSQSGWTKQNETSPAPATETVYIDRVVIVKVCQKCVYAQSDNGDFKLACSNPMEIEGTKKQVPVEEAKHLPAVPVALPKEPVSVEQKKKIVVPDTIIQQVCGCSYTSGPGSNGNGANGSNPGSSKNPGSGSDSPKNNGATGSNGKPGSGNNGANGSNPEGSKTPGSGPDSPKNNGSNGSNGPNGSTGSPSGLGNEGPNGSNGKPGSGNNGANGSNPGNPNAPGSGNTGAGSDAGSPKNPGSNGSNGPNNAGSNGVVAPSGSNPSKPTRVGSAGLPSGTNQVPIVSSASGNMPASVAMLFLAAMALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWW3</accession>
    <name>A0A7D5UWW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g044800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986567.1">
        <property type="nucleotide sequence ID" value="XM_066130359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWW3"/>
    <dbReference type="GeneID" id="26240373"/>
    <dbReference type="KEGG" id="mbrn:26240373"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="331"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="690" mass="75057" checksum="FE5AA7CE3A350174" modified="2021-02-10" version="1">MSAAPTSTSAPPPARKVKFVASDPSRGGLPVKRKQVQQACAACRRKKRRCIHADDAHAQEESTSEEHRGQDSSPSQASPSTGASVVTPRMRTAAVMHENGTVNNTSHTALALHTSQPPYSGHRASVAMPSQTDHLKQQSSRFVGDLNPEGMFLEVTSISAGASSQKGDVGIWLSSGAFGGTGQSSQFITSRPPPLMDHFLLPFVREHCLSCLPPPEDFARLKNVYIQKVHPIFPVIPIADIDNDLDHPCSIVLRQLVCLAAAADPELTEHYRLQNRGPGLLSPQDFSQSLSSSVRAILETSLITDRVMHIQALIMLSLYTQPTCAEESDLPAQLGGRAIHHIQTLGLHLLRYDAPNCDDLENLFCCVWALDRINAAEYGRPCLIHERDIGADLEACIRKRPPCFRLFLSVIQWLDQVVELYRPGPSAEASGLEKIAYIDLPVLEAMIVDADALKVPSSLIATIETFYHAVIILSCRLARPGTVHAASTLPPPSANARRSLAAERIACAVPRDHLSPMPFIPYAVSLALSVEYRKMRHSRLAMFRARAMSSFKRNCEMLRKYGDHFWSANVVAGLGERVLKEMERAATSLTTKDAASPVPLDVGSRSTSAGVQSQSVRQTQMLPGNTAGITSAVGMDNAVDFSLIDAISGQDVFGHIDPSFNLEAVDDVLEANLDIGLPLNWGDWGQFAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXL1</accession>
    <name>A0A7D5UXL1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="26246842"/>
    <dbReference type="KEGG" id="mbrn:26246842"/>
    <dbReference type="OrthoDB" id="2359405at2759"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7709" evidence="1">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="102" mass="10951" checksum="281359E83DDB8E4F" modified="2021-02-10" version="1">MSSTQSLQDINNQTMGTLAKSFPIVTLPNGDKLPTGTVGALIVNIKAYDAGDEHQRTALEPAIKAAIPVLRKVGMFDIFPEDDWIKGESAGRALVGRLAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXW5</accession>
    <name>A0A7D5UXW5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g063400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542543.2">
        <property type="nucleotide sequence ID" value="XM_014687057.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244492"/>
    <dbReference type="KEGG" id="mbrn:26244492"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="414" mass="46786" checksum="1F36E808FC510BF6" modified="2021-02-10" version="1">MADKANDSPGSGSHHNAQIEDDKFEGLFYGPRDLNHHSRWPHFLRLRGSILPYMIFPLLFVAAWASCVTIISRRVYHIGVSQVLLTVLGFVVGLSLSFRNSTAYERYNEGRKYWSQLASVTQSLARLVWVHASEREECQTEDLLAKVTFCNMLVSLSFALKHRLRHEPFTHYDDLQSRTGHLPIVAHEAEKKEWEKPTRWETIGLFLGFPMAEQNPRRLMKNPAKPLGNVPLEIHSSCSAFIQAIIDNGTLKTPGCHTSAMGLLAQVNDILNGTERILNTPLPLAYSIAIAQITWAYILILPFQLVDNLKWTTIPATIFAAYIILGLALIGREIENPFGDDVNDLPLEGFCEQIRQDIDIIMSHSPQSTEDAVKKDENAVLYPLSQHGYHALVSKSPEEIRALLRVKLQMPRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY60</accession>
    <name>A0A7D5UY60_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fumarylacetoacetate hydrolase domain-containing protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAHD2A</name>
        <name evidence="4" type="ORF">G6M90_00g054160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540988.1">
        <property type="nucleotide sequence ID" value="XM_014685502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY60"/>
    <dbReference type="GeneID" id="26246294"/>
    <dbReference type="KEGG" id="mbrn:26246294"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF100">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="281" mass="31445" checksum="47FA77E0296643C5" modified="2021-02-10" version="1">MMPVFQRLVRFIASDGQIYYGETGDDWQSELVGRTVKVFTGLDPWAPDFELSNQFATIQQVICPLDKVPNVLGIGLNYRLHVKEAGFPMPSEPVLFSKAADSLAGPYEDVPCHPVAKEVDWEGELCLVMGRDAKNIPEDQDPLSYVLGYTVGNDVSSRYWQRPERCGGHFNYAKSFDKFSPVGPVIASLQAVGNPEDLRLRTWVGNELMQDGKTNDLIFDLRRIVRHCSNGTTLRRGTIIMTGTPSGIGATMTPSRFLKDQDVVKIEVERIGTIRNKMVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY85</accession>
    <name>A0A7D5UY85_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g064330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540109.1">
        <property type="nucleotide sequence ID" value="XM_014684623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY85"/>
    <dbReference type="GeneID" id="26247145"/>
    <dbReference type="KEGG" id="mbrn:26247145"/>
    <dbReference type="OrthoDB" id="202289at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="385" mass="43436" checksum="E8B0402D13245703" modified="2021-02-10" version="1">MEQNTLKRRGVGLIGVDKQKTFGGYTLFCPLTSDVARLIDMDGKEVHRWRLPSRIGRHARILPNGNLAVNTLRPSPKKKTNDGGPFPFPFFNKYGGGIMTELDPDGNVVRQFVDPFAHHDQYHFGDGRLLYASLEPLSPEQSAQVIGGVPGSEIDGITYADIINEVDAQNNLVWQWKVSERLPRDEFPLQPHYTREHYPLVNSVLPLRDGKHVLASLRSVSAVIVIEKATGNIVWKIGSDVVAQQHNATELVNGNILIFDNGAFRPGESITYSRAIEVDRKTKKIVWEYRDRSSPICFFTPFMGSAQRLENGNTLLCESAFGRLFEVTKEGYICWEYLNPHFAEYPDAETARIFPGESNALFRAYRYALQDIPWLKAKLEKNGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYA1</accession>
    <name>A0A7D5UYA1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Arsenical-resistance protein Acr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">acr3</name>
        <name evidence="12" type="ORF">G6M90_00g063450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542538.1">
        <property type="nucleotide sequence ID" value="XM_014687052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYA1"/>
    <dbReference type="GeneID" id="26244487"/>
    <dbReference type="KEGG" id="mbrn:26244487"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="371" mass="41180" checksum="D69DFF7921542653" modified="2021-02-10" version="1">MAEPTPNDTKQHDTERQSPACAQKTSAFKSLGWLDKFLAIWILLAMLVGILLGNFVPSTERVLQQGRWVGVSIPIAIGLLVMMYPILCNVRYETLHRILGQKALWMQVLFSIVFNWIVAPFFMLGLAWAFLPDEPDLRNGLILVGLGRCIAMVLIWNGLAGGDAEYCAILVAINSMLQMVLFAPMAVFFIRVIGRPDSDDVAVQYSVVATSVGVFLGIPLGTAIVTRLALRHLAGEKWYNDIFMKLLSPWSLIGLLYTIIVLFAAQGKHVVRQIVSVVRVAAPLVVYFLVIFFVTLWVTRRLGYGYRIGCTQSFTAASNNFELAIAVAVATFGADSEQALAATVGPLIEVPVLVGLVYFVRWIGRRWKWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYB8</accession>
    <name>A0A7D5UYB8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g066410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539261.1">
        <property type="nucleotide sequence ID" value="XM_014683775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYB8"/>
    <dbReference type="GeneID" id="26247949"/>
    <dbReference type="KEGG" id="mbrn:26247949"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="24918" checksum="272451085BEBBD0A" modified="2021-02-10" version="1">MVDSLDARLQRNQRRDLQKHVCLEVLRLEPTPKIEQWSAELSRALAWLESLGLVQGDLRPTNLLLDNDDHLKLADFNSSCKIGAENLGLAPPWSRVLGKESGKLLGTYGLYGAQSEKFAFGSILFNLTRGFEPSEDKGAEAINLWHNMVFPELSGSLLDALTLRCWRGDFATLADLAKDVAVLEGAKRAATVTAIDDGYMNKMKRCCRKLLLNKFTGVDVGTPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYS6</accession>
    <name>A0A7D5UYS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Satratoxin biosynthesis SC1 cluster protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SAT4_6</name>
        <name evidence="9" type="ORF">G6M90_00g078300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545278.1">
        <property type="nucleotide sequence ID" value="XM_014689792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYS6"/>
    <dbReference type="GeneID" id="26241311"/>
    <dbReference type="KEGG" id="mbrn:26241311"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="327" mass="37365" checksum="4F2A4E2CF650C868" modified="2021-02-10" version="1">MCSVTGLLVLARLVFKQYFSYQRTLKTDDWVIIASVLVGLPCTILNTTGLTHYGLGKDVWTLQPATIAEFARYFYIQQILYIFLITSIKISLLCFYLTIFPGRTTRLLLWITVAFSASFGVVSTIVSIFQCTPIRFYWMQYVQEEDGKCLNINLLGWINGAVSVGIDVWMIGIPLSQIKKLELHWKKKIGAAIMFLTGTFVTVVSILRLQSLLYFYSSENPTWDLWHTAWWSTIEINIGLICACLPTVRLILVRMCPRVFGSTINSTMARSRASRGNSMLVRRQQVRIVSLDIQLENASSTKIKEEQWEPSLTAPEEQPDENFYHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZC7</accession>
    <name>A0A7D5UZC7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g080140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539512.1">
        <property type="nucleotide sequence ID" value="XM_014684026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZC7"/>
    <dbReference type="GeneID" id="26247676"/>
    <dbReference type="KEGG" id="mbrn:26247676"/>
    <dbReference type="OrthoDB" id="10353186at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="158" mass="18101" checksum="01FFF710D8ED841C" modified="2021-02-10" version="1">MCEYAAEYGLKAYISEILDDLDPETAKFERFTPTMKSFYTDLLRRCLQTERTSTEHERPWLSISKTVAYLVDKGADPNNQLIGREHVANTTWSAFLRDFEDRLRHGDQVIFDICCALISAGAPLDAPFGNSEFLREAKRSFSQGQITELLNAARRTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZE5</accession>
    <name>A0A7D5UZE5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g074970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987091.1">
        <property type="nucleotide sequence ID" value="XM_066131029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZE5"/>
    <dbReference type="GeneID" id="90967968"/>
    <dbReference type="KEGG" id="mbrn:90967968"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="201" mass="21836" checksum="72FC74C2F8C212E8" modified="2021-02-10" version="1">MAFVRGIVAITLAVSFTIVYVTLPTTRTFYSRAANARLKMAAEANPLDRLTLSLNQTRTSPPTVRVTVTNENDGPVTIILYNSPLDSIALVLGIMSITPDGAAEPLELRTMRASRIWPPGPYSLEGLGPGASATNDLVLREPTVPMDKLGKKATVFLQGRWMGVFARAEDKISRDDLENISSQPDAFQGEFKSKSIEIING</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V020</accession>
    <name>A0A7D5V020_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g074240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545642.1">
        <property type="nucleotide sequence ID" value="XM_014690156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V020"/>
    <dbReference type="GeneID" id="26241675"/>
    <dbReference type="KEGG" id="mbrn:26241675"/>
    <dbReference type="OrthoDB" id="5389296at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="38508" checksum="5E688F495B8687A5" modified="2021-02-10" version="1">MTPGLVAALMDHSPSRALCSHAPPNRTAFEAPCRELQSMNPPPTTPTPRRFLLAKRPSASETPAPQASQQFQSTPRFGSSSVPQHAQRRAHDLEDVDEDGDESCDSSPRVEAEPKGSRLQDTIEMKSDDLMSQDTERLSQSQYFSGEDVEGVPGTESSPLSPDGREAKRRRVSISPPAPSSSLGTPEQAATPARGHASPAEGNGSESPGELGGPSRRHQPVFQPAPRFKPTDNETSLPVLPGAFSPQHRGAKYLPGGHAAQLQGWLSEVKGWEGTRDEDSVLRLTVEEISPGEHMYLARGKSGGSGDLKAYILAGEGRLTGLGRRAAVNVGSVVVIEQPVWEVDLVGECWTVGCNWSVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V041</accession>
    <name>A0A7D5V041_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytokinesis protein sepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sepA</name>
        <name evidence="8" type="ORF">G6M90_00g062990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542583.1">
        <property type="nucleotide sequence ID" value="XM_014687097.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244532"/>
    <dbReference type="KEGG" id="mbrn:26244532"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="245"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1537"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="869"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1241"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1503"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="823"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1390"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="929"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1503"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1523"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1564"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1680"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1698"/>
            <end position="1713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1724" mass="191980" checksum="772A256AA02FFF98" modified="2021-02-10" version="1">MSSADKSRQSSGGRSLFSRSKNKDKRPTDGDHLDAASTISFRSSRHKRDSSSVSIDTPTSPDPGVNMMAGVITSIPYDNIPSGSRSPIPVDYLPGSEQAPARRDPLPHQLNKSGMDFHQYPSFDPSSARPRESNMTMASTGRQAQFQQWGPTRGSVASTVNGSHTSRYESYLDPNDGRSSGENLSLYSGNATHRDIGGATRSSQLALPSASSQSSYGSQPSYRESNRVTKFPGPFLTAHEGFYFPKPDDDNVIEQMFLQLMQKRGWHNLPEQARRQMMAYPPQKKWTLLYQDRLTEWQGEQKRRQTARSNQYAAPDITTYSDEEGTPEWYVRKVMEDKLDAKGLGSLEVNLRTQQIGWVKRFVECQGQVALVTLLLKINRKTVTGPPPDNARAEKNLDKGYDIIKCLKALMNNKFGADDALMQQKVLLALATCLISARITTRKLVSEILTFLCTWGRDGEGHIKVIQALDELKTQSGENGRFDAWMRLVEVTVDGRGKMGSLVGASEEVRTGGIGMENLLMEYAVTTLMLINMLVDAPEHDLQLRIHIRAQFTACGIKRILTKMEGFQYELLDKQIERFRTNEAIDYEDMLERENSSIKDSVEGDVKDLTDPVQIADAIQQRIHGSKAQDYFVSALQHLMLIRAQDGEERLRMFQLVDSMLSYVAMDRRLPNMDLKQSLNFTVQSLLDKLHTDSEARQAQDESLESRQIAEAAMAERDEMRARLELGADGLVKKMQKQLDEQARFIEAQRRQAEGLKAELNNVQTVRAKEAQRNELETRELYLMLRDAQDIAASNALKGKPGHSDNDNGSTNNAETAEQMQGILDRDRLMERLQRQLERQKTQYKLEGRVWGEAGGPSDRLRALREEMDDDNLESPAGSGTPPRDLTNSVLGSVGRQTRIPRKPLRSDRDAEDSVIEESEETEGEEGVIYERPRIVEMKRPTIDPKQQAGLVNEIGSKVKKYEGSDSEDADVDATPSHPSLESSTPRTSADDEALKTESAAAGPAPPPPPPIPGQIPGAPPPPPPPPPPPMPSLIPGGPPPPPPPPPPPPPPPPPPPPGSIPGSASAGSIPPPPPPPPPGAIPSGNYLPQKSTYTAPSIGLPVARPKKKLKALHWEKLDTPETSHWAAHAPSAEEREEKYNELSRKGILDEVEKLFMAKEIKKLGGGMAKSSDKKQIISADLRKAYEIAFAKFSQHSVEKIVRTIIHCDTEVLDNQVVMEFLQKDDLCNISDNVAKQMAPYSRDLTGPDATSQHREQDPSELTRQDQIYLHTAFELHHYWKSRMRALWLSKNFESDYEELNERINQVVTVSESLRDSVSLMNVLGLILDIGNYMNDANKQARGFKLSSLARLGMVKDDKNESSLADLVERIVRSQYPEWEGFANDISGVVAAQKINVEQLQADAKKYIETIRNVQMSLDSGNLSDPKQFHPEDRVSQIVQRCMKEARRKADQMELYLDEMIKTYKDIMVFYGEDPTDENAKREFFAKLANFLLEWKKSKEKNTKLEDMRRRNEASMKRKHTAQKGGAAAALGEGSASPTSTGAMDSLLEKLRAAAPQARDQRDRRRRARLKDRHQVRVASGQKIPDLAEVPDAETGLQNIEKAIDEEGNPIVSPGLSSPREGDEDVADRAAALLQGMRGDGDDDAAKRESLRQARRQTAEDERRSRRRRREKAGASQMSGTAEEAAAADGTAAGVPEAVEEEAEKEPEPDEGPMEGAKLEAENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V049</accession>
    <name>A0A7D5V049_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">amdS_2</name>
        <name evidence="6" type="ORF">G6M90_00g074930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987089.1">
        <property type="nucleotide sequence ID" value="XM_066131025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V049"/>
    <dbReference type="GeneID" id="90967964"/>
    <dbReference type="KEGG" id="mbrn:90967964"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF8">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="80"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="241"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="574" mass="62427" checksum="8BB06838437DF8E1" modified="2021-02-10" version="1">MRIEATSWEVKAAAKRAGTWAKIPLSWRLSAGDLQRAKNQRDLTGPFIRQFLPENVNIITSKDSLELVESLRRGDLTAVEVTTAFCKTAAVAHQINNCLHEIFFDEAIERAAHLDAHFAQHKTVVGPLHGLPISLKDQFHVKGVDTTMGYVGWIGSNLGVTHPSQIHKLESQVVSELLSLGAVLYCKTSVPQTLLFGETKNNIIGQTLNPRNQNLSCGGSSGGEGALQALRGSTLGVGTDIGGSVRIPAAFNGIFSLKPTPERVSYRDVANTNPGQNTYRSTVGFLSTSLDGLELILRGILSTKPWLNDPAVVPMPFRQDFVDDYTCRVERNGSVKKSKQPLKLGVLWTDGLVQPHPPVTRGLNTLVAALKGAGHLVVDWNPPSQKTGGRVHQSFLTADGAHGIHGHLNLSGEPLIADLQEEFQLKPPIGLLQYQESTLEGLSYEAKYSDYWNQTASDDGQIVDAVIMPVAPHAAVIPGKYYHTGYTKVINLLNYSAVVIPVTKADKSIDAIDGSYCPQNGTDQRNWDAYDPEVYDGAPVGVQLVARKFEEEKILAIAKIVVAVLEEAKNNGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0P3</accession>
    <name>A0A7D5V0P3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosome production factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RPF1</name>
        <name evidence="3" type="ORF">G6M90_00g087590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542357.1">
        <property type="nucleotide sequence ID" value="XM_014686871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0P3"/>
    <dbReference type="GeneID" id="26244871"/>
    <dbReference type="KEGG" id="mbrn:26244871"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="179"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="413" mass="47370" checksum="E5CE9C5591F740F3" modified="2021-02-10" version="1">MGFTKPPVQALKAANKLKRQELFIQHKKASGKERREARHRRRKEENREPELKTARLAKNKTLTLDQKRVWDEGNDDSLGAQVDLEKLRRRQMEEAEAEERAALDAEMKDDDDEEDNDSMLDSDDDEDDEARQAALEKQREKRAKRDNSVAPSTTSTNLDLTPSSLALKFPSLFSDIPAPDPKVLVTTSLNSTIHYEAQLLGTLFPNSTYIPRSSHRYGHKYSLREICKFATNRDYTTVLLVKEDLKKPTGLSVVHLPSGPTFHFSISNWIEGRKLPGHGNPTNHYPELLLNNFKTPLGLLTAKLFQTLFPPRPEFQGRQVVTLHNQRDYIFVRRHRYVFREKRATEKSIAGADGKEMKGVEGIRAGLQELGPRFTLKLRRVDKGIGRAGSEGEDATQWEWKAKMEKDRKRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V255</accession>
    <name>A0A7D5V255_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Vacuolar amino acid transporter YPQ3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g086310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542483.1">
        <property type="nucleotide sequence ID" value="XM_014686997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V255"/>
    <dbReference type="GeneID" id="26244997"/>
    <dbReference type="KEGG" id="mbrn:26244997"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI72151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39410" checksum="45C592E71514DE9C" modified="2021-02-10" version="1">MAPPLANLHLDVEAISGICGSISIACWVIVFTPQLIANWRSSSAEALSVQFIIVWLIGDVFNIAGAVLQGVLPTMIILAVYYTLADIVLLGQCFYYRGFTWRDEPATPTPKPSPQFNGNATERTALLGDYEYHRERRGSDWTGLSLTVPHISNAEPPPPPPSALQTLIWNMSIVLMVCAAGVLGWWLGDSATSTDKEPKAGGEDAIEFNLLGQVFGYLCAVFYIASRVPQLILNYRRKTTEGLSMLFFIFACLGNVTYVLSIFAYEPECQHEECRPGETGRIYGRYMLLNLSWLAGAMVTLFMDLIVFGQYFYYNRNETDKEARCCDEANAGGLLEETYYDQRPLLQRTDSGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2G4</accession>
    <name>A0A7D5V2G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC multidrug transporter C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">abcC_1</name>
        <name evidence="12" type="ORF">G6M90_00g105360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987673.1">
        <property type="nucleotide sequence ID" value="XM_066131674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245773"/>
    <dbReference type="KEGG" id="mbrn:26245773"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="526"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1155"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1285"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1405"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="65"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="788"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="761"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1439" mass="161343" checksum="496BAE808139A5D3" modified="2021-02-10" version="1">METQHGFNPPEVADNAGSYQALLEEWLRTQKARRRSRIGISFRNLQCIGRRASEQYLDTYISALTRPCRAIRSRQQVQILSGFEGLILPGEMLLVLGRPGSGCSTFLKTLSGDTHSFNVGAGSVINYQGIAQINMYPSQAEMNKLKFYLTCTGTSFKEMHHNAPGTCINLGELDVHFPELTLGQTLEFAASTRPSHNLASEQHNDTQRAEGTARVIASLFGLSSGYDTRIGDALIRGVSGGEKRRTSIAEAYIGGAQVQCWDNSTRGLDSLTAQRFIDFLRRSTDVLRSTVAMSLYQASESMYKQFDKVMLLYEGREIYFGPIDDAADYFTALGFARPINATTPDFLTSMTNPAERVAREGWGNRTPRSRDDFVSAWNMSRQAKSLRDEIAEFELANPIRGRGSSHLTDKEATGDVASLPPSTFSLSIYKQIMVCLRRAYQRQRNHFVPVVSMLAANVILGLIIGSAYYNLDEGSDSLLPRSTLLFFVTMLNSFVPAFEVDLMYAQRPIVEKQSQYAFYHAFVERVAFMILDFPAKVALSFMLHLPIYFLTNLRRTGESFFTYWLFMMVNLLAMAMLFRMIGFLSRSRDGTLTPVSILTLLCVLYTGYVVPPPYMVPWLGWFRYINPIAYTYEGVMINELRHRQFLCSTTIPDGPDYRNITSAEKLCMEVGRLAGTDLVDGTEFLRLKYGYVEAHMWRNMAILLAMMVIFCIGHLLAAEYIPAQKSRGEVLLFKKPLPKLECSEETGISESEIGAIDANLGSKTRGQGAHTEPDVTTPMQRSRQTSTFQWSEISYDIKTRGGNRRLLSDISGWLKPGSLTVLMGATGAGKTTLLDVLAARALRGKVHGTIFVDGRPIGATGDYQQRMGYVKQDDNHLPTSTVREALQFSALLRQPSTRSRSEKLAYAETVLKMLDMEAYAEAAVGVPGEGLNVEQRKRLSIGVELAAMPDLVLFLDEPTSGLDSQTAWSICTLLRKLADNGHTILCTVHQPSAQLFNQFDRLILLRSGETVYFGDIGPEATVLKEYFESRGSRKCSIDENPAEWMMDVIEDSTKPADDQQAWSQKWNSSTERQEVLDQLAGFTNQRDHQAVVPADARRQNQGGYGATMLHQLLILVQRTFRDQWRNPIYLYTKTATCFGLSLVNGISFYKTDSDIQGLISLLFSCFLTCQLFSILSMLIIPRFIRARHLFEVRERDSKLYSWVVLVAANLIVEVAWFTLISVFIFVCWYYPTGMYRNGDASFGVIERGGLAFMLLWLFIIWSCTISQAFAAIIEEIETAIQMSTLCFWLSLVFCGILVTPDHLPGFWTFMYRVSPLTYYLEGIAIAGITGIQVQCSAVEMLHVPLPPGYGSCQTYLQAYMRDTGGYVVNSESADGPCVFCPVSRADTVLQSLGLSTDKSTAWRNVGILTGYIVFDVICVFALYYLLRVPRFKAQSSIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Y1</accession>
    <name>A0A7D5V2Y1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA oxidative demethylase ALKBH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ALKBH2_2</name>
        <name evidence="3" type="ORF">G6M90_00g097470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987659.1">
        <property type="nucleotide sequence ID" value="XM_066131529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Y1"/>
    <dbReference type="GeneID" id="26241017"/>
    <dbReference type="KEGG" id="mbrn:26241017"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="36041" checksum="063BC99C285CBEB8" modified="2021-02-10" version="1">MAQKRTLDAFFTVVPKRRKENEPDQDAGHSAHPAYPFPIANLPALMVRDVASLPARPGRRINDQPDLDLLYFEPYIPAYLGKQMFDFLRSELPFYRVEYDIKRGGYQTHIVTPRWTTVFGLDDTSYFDAAGAVTDKLSTMKANDKRYDRYPPRPIPQCLDALRKSTEAATNCKFNFCLVNYYASGADSISFHSDDERFLGAEPAIASFSLGARRDFVMKHKAPRPGESAAATEARRVKLALGSGDMVLMRGATQSNWLHSVPKRTGRNQDDGGRINITFRRAMVKDGTENYYNYNVGRGPVYRWDKTSRQMVLWERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3G1</accession>
    <name>A0A7D5V3G1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g105130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987708.1">
        <property type="nucleotide sequence ID" value="XM_066131667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3G1"/>
    <dbReference type="GeneID" id="26245752"/>
    <dbReference type="KEGG" id="mbrn:26245752"/>
    <dbReference type="OrthoDB" id="4938365at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF211">
        <property type="entry name" value="CYTOCHROME P450-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46424" checksum="77DC79D9F84C3D4F" modified="2021-02-10" version="1">MEPSQLPARAVELIPRLCTIFAPHLALSGEEPPYRNSGAGLVLVSPEEISLHIADPDMIGEIFARWRDFVRPVQKYRMLAIYGPSIFTVGLDDWPRHRKAVVGPFNDDLMSLVWRETLCHTRSMLHAWTTQFRGDIPSFENDLRALTFNVLGATAFHERPQSQADTRPKDSEKIAEDYQDTLRTVLDNSILLMLIPYHRLRGTITPRHLARVGLAAESFRSILLKVLREETAALGSDGSKQNGLLKPLVRALKPDTREQAKNSAAPVSAKAKKTGLSVDEILGNNFVINFAGHDTVRLTLNFTLALLTVHPDVQEWIYQEIKMFSGGHPNDEWHYDMFPKLKRCQAVLLETLRIFPPNTGIPKTASHTAPSLRLGDQLLVTPPGDRGLPVADRCPDGRQVLGRPIYLATISLDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3U4</accession>
    <name>A0A7D5V3U4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g110210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543837.1">
        <property type="nucleotide sequence ID" value="XM_014688351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3U4"/>
    <dbReference type="GeneID" id="26243224"/>
    <dbReference type="KEGG" id="mbrn:26243224"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="215"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="293" mass="32416" checksum="5CBE602607AFB599" modified="2021-02-10" version="1">MGCCFSRSSGPNSPYPGGATNASARHINPPALALPESVQAGSQVLPRRRHRDQGPLDEHINKPLRRHVWTSADRQWTKQQLDNERAEFFDTRVTGRSEIWQTIRAAVAVLQEPGGEGSDALATAQSILSAAEISLPTGDLANGVYDSLGNYYQLPQWVVSDPSNLATLCEGVDVPDMSTTGDDDTAEEEVDPVSLVDDSERRRHEKGKEVIDGYDQITLRARLSETGRDFEIHVSKSDTVRNIIRKLACEASLPTEKKIRIAYMGKMLKDNQPLEIQGWQTGHVVNALVFNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4D7</accession>
    <name>A0A7D5V4D7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADIPOR-like receptor IZH3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g098260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546518.1">
        <property type="nucleotide sequence ID" value="XM_014691032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4D7"/>
    <dbReference type="GeneID" id="26240941"/>
    <dbReference type="KEGG" id="mbrn:26240941"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57777" checksum="982A8535D6015173" modified="2021-02-10" version="1">MSDVTTAITSACGYKPRDDEQLGTCAVKASGSEVQNTDPPANQRRRHSFFLPRRKSIVETIMEGEEGLLLKVDLFLSELERRLDFIESYYDDLGRDYSFSRAFSTLQAVRTRCSQASEEVIGAGRRRLQIMVETLEMRYQETLTAAESMHEKARVGVDLLEEMLSEFEARAHKLREQGLAGATTAAEAFMDEGRRVAHESIERARGVMDEGLERARRAALSLEEHIQQAVAKARETRLLHYNDLPMPWRNNPHITKGYRFTETKIECVQSAFNISNEFINIWSHAIGLVLVLAVALYFYPASANFSLSSKSDVFVAAVFFVMACLTLVCSTIWHTMNAVADVDAISIFACVDYTGISLLIAASIMTTEYTAFYCDPLSRWVYMTLTAVLGIGGVILPWHPKFNGTDMAWARVAFFVGLALTGFMPMLQLSLTHGPDFVLTFYSPIFKSILVYFVGAIVYASKIPERWWPGMFDYVGGSHNLWHAAVLGGILFHYTAMQTFFSNAFHRAEGGCPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V596</accession>
    <name>A0A7D5V596_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">G6M90_00g093390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539425.1">
        <property type="nucleotide sequence ID" value="XM_014683939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V596"/>
    <dbReference type="GeneID" id="26247785"/>
    <dbReference type="KEGG" id="mbrn:26247785"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028965251" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="28"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="51188" checksum="48F4F499789AAF04" modified="2021-02-10" version="1">MRVPFQGSWGFLTLLVAAVMRVSVAQAQSPGFAALMQLPQCAINCMNTPGFNLSACNVDDLPCLCHLLSSDAGKSVSTCVVTDCSVKDSLAARNLTQQACGPEPRNQSTTYTTVAVVFTILSSLAVIQRFAVKLWFPHISIDLDDWLVLATALCQLSSAVLGVAGGVPNGVGRDIWTLSYRQITNFGVCLYIYAILYFANVATLKLAFLFFYLRIFPSMLIRRLLWVTIGFTIVYGITFILTSVFQCKPISYYWVHWDGEHQGTCANISEIAWANGAISIAIDIWMIAIPLSQLWRLKLDWKKKVGVFIMLSVGFLVTIVSIIRLQEIITHAIDDPNATWAIMNLAVWSTVEINVGIICACMPSMRLLFDLVFRATSPRLAASATNEANVHNSGRLFSRGRGLGVTSHSVFEPYFAPLSRQTGVITVQRTYNIEVETLNENLEEAQLVYMTNLSNDKQKHAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5N6</accession>
    <name>A0A7D5V5N6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539763.1">
        <property type="nucleotide sequence ID" value="XM_014684277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5N6"/>
    <dbReference type="GeneID" id="26247428"/>
    <dbReference type="KEGG" id="mbrn:26247428"/>
    <dbReference type="OrthoDB" id="4945774at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="746" mass="82491" checksum="42DC62B70D58F96A" modified="2021-02-10" version="1">MVTLELEDAPSPHHARKERQRAGPDTAPRAQHEQVVALYGRRQRLLSAYMARHHGSSWSTSKGMRRIARRLGRCPREPQVRTDAEQEFARLLTAHSLVGMDAASIGILVWDQMSPAPDTSGATRPETAGAKDRRGQSKPLMVRSGGLGDGVMPFCCDSLYDYEEYADGGNVLWRTTATWDHIFDEAAYARKDAMCQAEVDESNADDWGVAAGFARYEHGLLRHPKYTLHGSKDLGKQFVCLFKGNERLYDCSQTVSALARAAQISPLASTAIRVTEYSLYTGGPVAVPPPHSFTFPSQVVVPNLQRLGEAGCVHLDGVEVKNTKRHRAEAISMAQPRRVADFLRAGDVSPCFYNMCIVAGRLRYDCLDMMMGSYAFTMADYADRFGADKTAATHGWADAVLNSFVNPRAVHYNIESSMCTADVIVQRLIDNYEGGALPSPGELLDARWIDGALPQFIDVALRCQLGGGTYKGWYDSGCVYVRQALDSVATLHDVWDLMEDTAGGEGGNVCRLYTKEALCHVADWCHDIGRRLAECGCGDGMHGFGYVWFLVSELYYVTIARWGLLTARGRGHAPLSYHSREPWLADGTPYWTTDVARAKAARTRLVEAIIGRASRDLPALAVAPDVDPEMRSLMRMWATVSNRSLADSVQMHYHMSNAVAACAPRGVRRADVDWRTWVEVYNALSYDVSFNPDSPYRCVTSRYADVLRVELGSNGRIAHAINTHVTDEYACHQRNSGGTAAYADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5W6</accession>
    <name>A0A7D5V5W6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g101970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546149.1">
        <property type="nucleotide sequence ID" value="XM_014690663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5W6"/>
    <dbReference type="GeneID" id="26240572"/>
    <dbReference type="KEGG" id="mbrn:26240572"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22150" checksum="0075FCED483356A5" modified="2021-02-10" version="1">MSADTRPISPGRFATALKDLSVPMLHLKVLEIRNSIAHLQYSNDQLKPFAEGSATALGDEPAHGPDQDCVDAIRENEAVIDRMAERIALVRAEVEERGVSWAEFQSKEEAEAAADKARAEEAQVNGHGQRRGTHSAWTDGTFQTGTIRDGQIHMDTQPPPTAGSGNNSGGRLNDEELRQAIEERLRTLGNEGDGDGDGDDGGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLA1</accession>
    <name>A0A7D5YLA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CUE1</name>
        <name evidence="13" type="ORF">G6M90_00g023470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CUE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548208.1">
        <property type="nucleotide sequence ID" value="XM_014692722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLA1"/>
    <dbReference type="GeneID" id="26237652"/>
    <dbReference type="KEGG" id="mbrn:26237652"/>
    <dbReference type="OrthoDB" id="3824970at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000050">
        <property type="entry name" value="Related to AMFR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20750" checksum="C69A5250726D2537" modified="2021-02-10" version="1">MANEQISLPYLAGILLLSGLIIRYLFFSGTQTPRPTRSPEDVRRSRETAVERIQQMFPQAERRSILWDLQRNGGSIQNTTERILAGRLETPPVTFQPPPPPGQATAGASTVSATRQADKPSQPDLITRYNLKSKITEAEFEEDAKSKGWSSNRDERQASLQKRRDEMILAARRKMEAKIAAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM58</accession>
    <name>A0A7D5YM58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g022280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985576.1">
        <property type="nucleotide sequence ID" value="XM_066129891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM58"/>
    <dbReference type="GeneID" id="26237770"/>
    <dbReference type="KEGG" id="mbrn:26237770"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="17"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31609" checksum="A524DFCF1F18E2FC" modified="2021-02-10" version="1">MATTSQDKSTRTIHSAACLIIGDEVLGGKTVDTNSAYLAKWCFSLGISLKRVEVIEDDEGEIMEAVRRMSDRYDFVVTSGGIGPTHDDITYQSIAKAFDLPLKLHDEAFQKMKVLSRPDTLTPNFDWATDSPALQAKLRMVRLPTDESRDLKSQFLFVSDNLWVPISVVNGNIHILPGVPSLFQALLDGMKPFILPRLVDPEGKGTCRILISTPMPESAVAAYLTELAARVEAKGVKVGSYPRWGKKRNTVTLVGRDQAFLESLVAEVEENVQGRRVSQEDEADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMM4</accession>
    <name>A0A7D5YMM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Syntaxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">psy1_0</name>
        <name evidence="6" type="ORF">G6M90_00g010980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549423.1">
        <property type="nucleotide sequence ID" value="XM_014693937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMM4"/>
    <dbReference type="GeneID" id="26238867"/>
    <dbReference type="KEGG" id="mbrn:26238867"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="37915" checksum="0644D2A04E7FEF87" modified="2021-02-10" version="1">MSYQQNPYSPAPPQDAGRAESEDNRWGVGRYEMQPLNNQRPVSYQQPVSYQQQPPPQQQHDGLSEAQFLDQVQGLRNDMKAFNQSLDELSKRHKRSLADRDAKDQFGDYRFEVQNQREMLQDGVRRLENDLASTSPSDKARQTKKRHLQSLKTPLQKVVEKYVKVEQDIRNGEEAERIRQLGLVHQDWDYSRLQEEARRDWGNEGVFQDALMNNRSEQATQVLGNVRARHQDLQRLEKDLSEIALLYQELATMVEQQDETIVATEQNAEYTVDNMEAGNQQVKVATDHARRARKLKWWCLLLCVIIIIVVALGVALGICLNGNRCSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN93</accession>
    <name>A0A7D5YN93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EMC1</name>
        <name evidence="15" type="ORF">G6M90_00g001640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542912.1">
        <property type="nucleotide sequence ID" value="XM_014687426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN93"/>
    <dbReference type="GeneID" id="26244285"/>
    <dbReference type="KEGG" id="mbrn:26244285"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028969045" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="20"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="937"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="736"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI64341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="970" mass="104517" checksum="D6F9DA5EC05AB7A9" modified="2021-02-10" version="1">MRRTLQSALLLGLSSLAGAVFKDEVGDIDFHYSLVGLPQVETTFFHRPRKEDKASLLYTLGDVGVIGAINPSNGELIWRHQISHGIANGGGHLRAPEGENWVTSAYGPKVQAWNALTGRNIWDMEFKGVVKDLEILELTESPRKDVLALFDEDGVTVLRRLHGALGTVVWEFRETSKDLPVQVSTNIANIYVLSLHGSPGSYNLKVTSLDMATGARVDHWSVGNKGDIHGAEDVMFVGANSAAPIAAWASRGLSKLSVNVLGTKTKQEFTLPDGTETLRIHAPHLAQSQPHFLLHIGTKTGHKAIVYHTDLKSGQVSKAYELPHLSGPGAFSTSSDAANVYFTRITANDISIVSSESHGILASWPYLPKDGHAAVHAVSEVIKKAGGKEFAIRSAAVTDADDWVLIKNGQVDWTRHEGLSGAVAAVWAEIPEAERLAEVLAEEAHANPVAAYIHRVNRHIADLEHLPAYLARLPQRIIDGISGADLTGHKDGLHRDTFGFSKIVVVATRRGRFYGLDTGRQGKILWSQAVFNVDPGESLAIRGIVAKDAESEVTVVGSNGERATIASATGRILEAHQAGSFTKVASTAVIGDESSQWLLSLGANGLPVPNMPIGTIPNDTIVLRDGSLGVKGVKFTAKDGEVIKDDIWQFQVGKGQKIVDIVSPPSHDPISSIGRVLGDRKVAYKYFNPNTVVVAAIEEATSTLSVHLLDIISGQALASQVYNGVDSTKGLSCAMAENWYACTFFGDYTVNDGTDRTIKGFQVAVSDLYESPEPNDRGPLGDAAEFSSLNPVDTPTGVPLPHVVSQAYVFSQQLKSLSVTQTLQGITSRQLLAYLPDSNSILAVSRHIIDPRRPVDRDPTPAEVEAEALMRYTPQFEIDGRGIVSHELDVLGVQEILATPAVIESTSLLFAYGVDIFGTRAAPSGVFDILGKGFNKVTLVGTVAALFVGVLFLAPVVRRKQIDRRWEAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPW4</accession>
    <name>A0A7D5YPW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein transport protein BET1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BET1</name>
        <name evidence="12" type="ORF">G6M90_00g034410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986454.1">
        <property type="nucleotide sequence ID" value="XM_066130150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPW4"/>
    <dbReference type="GeneID" id="26239402"/>
    <dbReference type="KEGG" id="mbrn:26239402"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="76"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="166" mass="18560" checksum="F01183885ACEA762" modified="2021-02-10" version="1">MAQRFGASSLHQRDSRSALFEGYTGGDHTPRGHSPNPYNPGYAAAYPNGGHSERHGLGYRAATPNRKGQYSDAVLDELESQNEDQVAGILGKVRTLKHMTVAIGDEIRESSALADKMNDAFDDARMRVRGTMNRMKIMAERTGVGWRLWLLFFAAVGMLFFYVWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPX6</accession>
    <name>A0A7D5YPX6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g012400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549282.1">
        <property type="nucleotide sequence ID" value="XM_014693796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPX6"/>
    <dbReference type="GeneID" id="26238726"/>
    <dbReference type="KEGG" id="mbrn:26238726"/>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53368" checksum="25CA70F31D11A554" modified="2021-02-10" version="1">MAGKGSDGKKRPVALNLAPKRSNSSNSSSTNNSLKIPRTPRFAEATSVHSPVDMKKSPFADPEQPTEGTSQPGDVGFGYIGNDHDSAAGPKSPLKSAMKVPGTPARQLSNPLSPTFREEEMLEKREVSTDKEQVKDIKIKTRVRMAKFALRGVNFSCSLIILSMLSASFAIFNSTKSLAAASKFTPWAPNTQQTAWPQKLTLAMACVSLFACILVFFAYCRGGHRRATKVNTYYTMFAIGWFILSMLLWVVTAVIFQHSKNNSNNKDMWGWACTNNQRAEIYHEKVDYALVCRLQNWTLICIIIEVVVEVISIALYSIVFYRFYSKRRLMKSMDMRDRARSDLYLAQLRTQSAPNTPGFGPKSPALSSYAMSPRHPPAAYRNLSDIDETSPFTPGGKVVVPQSQFGTPSPDFKLQPPPTKAPSATPKTVQAAFAPPATRTPSPPVQPQHAPAPADEPTYEAVPIPGAYAGQAVKSPPPGQMTFGVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQL5</accession>
    <name>A0A7D5YQL5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g044140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547748.1">
        <property type="nucleotide sequence ID" value="XM_014692262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQL5"/>
    <dbReference type="GeneID" id="26240311"/>
    <dbReference type="KEGG" id="mbrn:26240311"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="509" mass="56575" checksum="AE1427DDF925D911" modified="2021-02-10" version="1">MGTATEFYRSQIGGTSVINYSYTDFPFKLLLKDVHYFFVYCWALPWILLPIRPCGSGELDELYPSGKNIFCILIHFILVLLQLAFILVLPLGIIFPVWITALGVGGFMTLNWALCKLLNGKDITFHSDEKYAKARPEHAHEQWVFLNGVAVGDHWMMANLNRLAITFGRPILGIHNRTSGILFDVIECLVQRNFTYATSDVRICYKILRDVLYDPSKSKVVFILHSQGGIEGGLVLDWLLQEMPQDLLSKLEVYTFGNAANHFNNPHRHVASQNLSATNPLVAIRTFVSESSFSTPVTSPVGATNGHAKGGDPSALTTSGTSESFSSSRVSSAAKDRAIGHVEHYAHSTDFVAMWGVLHFATNRMGSHQLPRFLGRLFNRATGSGGHQLNQHYLNGMFPLERDKKTGEFIGADEENAFMEEVIKFGKEGDAMENAREAFDISYLGTEGFGTGHISTPVEVHGTRGRKRTKTDVMVKELSRLWSYRNGRSPGGEPPNLVTEAGFCRNATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRE4</accession>
    <name>A0A7D5YRE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ayr1_1</name>
        <name evidence="7" type="ORF">G6M90_00g052090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539403.2">
        <property type="nucleotide sequence ID" value="XM_014683917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRE4"/>
    <dbReference type="GeneID" id="26247803"/>
    <dbReference type="KEGG" id="mbrn:26247803"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="30979" checksum="CCA4F3C0EF3E975B" modified="2021-02-10" version="1">MSTRQSALVTGASRGGLGDALAQELHARGFRVFATARTLPKVQHLKDLGMDVVKMDVADSTSIRNAAAQVASLAGNRLDILINNAGTGYQSTLLDADIETARQLFNVNVFGVLDVTQAFGPLLIASKGIIVNAGSVLGRVPMPFCGVYNASKAALDSLSKQMRIELAPFDIRVIHVNAGGIQSDFLSHAAGPKGLPDKSPYYAGHGVLNPWISGEITRSKYQPTRRQDYAKSVVDAIVKHNPPSCLWTGYSAWVIWFTTSFLWRDATDLMMWAMGAPDIKVAISFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRR5</accession>
    <name>A0A7D5YRR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5'-AMP-activated protein kinase subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SNF4</name>
        <name evidence="7" type="ORF">G6M90_00g065310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986777.1">
        <property type="nucleotide sequence ID" value="XM_066130802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRR5"/>
    <dbReference type="GeneID" id="26247052"/>
    <dbReference type="KEGG" id="mbrn:26247052"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="292"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="442"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="503" mass="54466" checksum="754AC70DA3DAA3A2" modified="2021-02-10" version="1">MDERDAAAAPPSVQPAADPTQTNVEAQIASREQVTGAMSGLAPGLGSGPSAEEPPPSAQPPTAARAQAQASNPATRSITTAPVPGRAPATATAPRSAPAPVAAPSHGHGHGHEQPALRVPRFVAPSSYLRFKTSHGSAMAAAASEPTSNPSTLSPPSPLDKEQRQGLKAIRDFLKVRTSYDVLPLSFRLIVLDTDLLIKKTLNILIQNTIVSAPLWDSQRGRFAGILTATDYINVIQYYCQFPDEMSKLDQFRLSSLRGETILHQATVEKAVGPAVCMLRQVGLDIEKAIGATPIETVSVHPSRPLYEACRRMLKTRARRIPLVDIDDETGRETVISVITQYRILKFIAVNNEHNTVMLKKTVREIGLGTYSNLATMHMDNTVLDAIHLMVDRNISCIPIVDSENRVLNAFEAVDVIPCIRGGAYEELDGSIGEALCKRPDDSPGIYTCGEGDRLDSLFDTIRKSRVHRLIVIDDDNKLKGVISLSDILKYVLIQGEEDSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRX6</accession>
    <name>A0A7D5YRX6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Clock-controlled protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g064390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540104.2">
        <property type="nucleotide sequence ID" value="XM_014684618.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRX6"/>
    <dbReference type="GeneID" id="26247140"/>
    <dbReference type="KEGG" id="mbrn:26247140"/>
    <dbReference type="OrthoDB" id="3836772at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028844907" description="Clock-controlled protein 6" evidence="2">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="28408" checksum="E36620271ED6D220" modified="2021-02-10" version="1">MSSLRMVVLGSAVASASAIAGVHNNSTATGHIVYTTEVVTALTTYCPAPTTLTHGDKTYTITSATTLTITDCPCTISKPVQPTAVPTPAPGCNDKCQATYDQCRGKPGANLSTCVSDFEGCKASCTGATTAAPSKPVSPTVVPAPAPGCNDKCQATYDQCRGKSGANLSTCVSDFEGCKASCTGATTAAPSKPVSPTVVPAPAPGCNDKCQATYDQCRGQSGANLSTCVSNFEGCKASCTGASAPAPPPAPAPTAAKPSGNSTTPVTAGAGALAPAKVLLALGAIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS34</accession>
    <name>A0A7D5YS34_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetamidase regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">amdR_1</name>
        <name evidence="8" type="ORF">G6M90_00g054730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540932.1">
        <property type="nucleotide sequence ID" value="XM_014685446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS34"/>
    <dbReference type="GeneID" id="26246238"/>
    <dbReference type="KEGG" id="mbrn:26246238"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF4">
        <property type="entry name" value="ACETAMIDASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="584" mass="65548" checksum="E602C13A19BFDE98" modified="2021-02-10" version="1">MCGNDAHQRRTPPQDERLEPDSGNLADLVSGEAIRTAQINHQSRMCFIGSEPSNFNYLVRQTSSQTSQDRIFHFSNRQYHLKYTAHDIDRIPHEALERPTKPLIDKLVRAYFVHINRGWPIVDEENFLDQLEEKDPRNPLSLPLFNAVLLVGAHVLSFQEDFEQMKQLQSVLFRRTKTLIDCRFDQDRFAYVQVALLLTWYSDGLEEVVANAWYWLGTAARTATGLGMHRDTTTSRLLDVHKRSWVRVWWVLFQFDTLISLSYGRPQSLNLDDCDVPDLEYAHFQGISQPEADFAIHQTRLCVIISRTFRQRWALRATTEQRTRAAERADQALASFITELPAPLQMSLANSGTWHAVLHLTYNHFVLLLHRPPPKHKSHDRASLPAGNPDICAEASMGLVSLLEGLHLTRRLYALSLFDVQAIFTAVVAANNELGTSNPLVVVKAVQKLKSISSTLTVLARNWSFARGLLRIFDSKGQLTLNKGRREAASDPASHGHECGNRCHDAPGSMTGSQAAFSPSQETRQNGGVFASAITPSETAHNSPGSLIGNDGVPLGNPLDDFVFPGAFELEDFLLGVDKDGVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT47</accession>
    <name>A0A7D5YT47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g071820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987096.1">
        <property type="nucleotide sequence ID" value="XM_066130959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT47"/>
    <dbReference type="GeneID" id="90967936"/>
    <dbReference type="KEGG" id="mbrn:90967936"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028940632" description="Fe2OG dioxygenase domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="258" mass="28848" checksum="51A6457273727188" modified="2021-02-10" version="1">MSCKSLAYGAILFMLALLTHGETQTPLSNEFECVHPPYKVYVASKSPLVMYLEGFITPEERRHLLELAYGNDTFKHSYVTSDSSQTIHAVRTSQSTSVRRSPTVRCIERRALDLQGLDVPVSNVEPIQLVKYAPTERYHFHTDWFTDAQHAVASLGGNRASSIFGYIKAEGVVGGGTNFPFLDAKSGEWCRFVDCDEEYEKGVTFRPVEGNAVFWENMVSGRGDERVLHAGLPVVRGEKVGMNIWVREGKVPDELRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU04</accession>
    <name>A0A7D5YU04_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carnitine carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CRC1</name>
        <name evidence="13" type="ORF">G6M90_00g024910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548090.1">
        <property type="nucleotide sequence ID" value="XM_014692604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU04"/>
    <dbReference type="GeneID" id="26237534"/>
    <dbReference type="KEGG" id="mbrn:26237534"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000060">
        <property type="entry name" value="Mitochondrial carnitine carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="38"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="136"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="244"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI63845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="34790" checksum="80645177338FB368" modified="2021-02-10" version="1">MPSAAENLPAPVADKLPRLPETKEELRETKDAAKSGLLSQLRALAAGGFGGICAVVVGHPFDLVKVRLQTAERGVYSSAVDVVRKSVARDGLRRGLYAGVSAPLVGVTPMFAVSFWGYDIGKQIVSATSAVGPEGLSIGQISTAGFLSAVPMTAITAPFERVKVILQVQGQKQLAPGEKPKYNGGLDVVRQLYREGGVRSVFRGSVATLARDGPGSAAYFAAYEYIKRALSPKDALTGKPTGELSLTAITCAGAAAGVAMWIPVFPVDTVKSRLQTAEGNVTLGGVIRELYGRGGFKAFFPGFGPALARAVPANAATFLGVELAHQAMRKAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU93</accession>
    <name>A0A7D5YU93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g064120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986853.1">
        <property type="nucleotide sequence ID" value="XM_066130772.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247166"/>
    <dbReference type="KEGG" id="mbrn:26247166"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1191"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="12">
        <location>
            <begin position="158"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="823"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1009"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1307" mass="146329" checksum="84C1CEC0488CA71E" modified="2021-02-10" version="1">MLSRSATSPAVARDSSSLAVNPASPPSLARHDAASPLWHSSDHSSSSVASNLKQGADIRNDSPQPRFTMDPEGHLTHDKTTVDIITVPCPGGHPLRSWNRDGLMSRYYGALSMRDPEVKDDAERPTPSWVRQGIRREADKARILLYEHPEMDEGTTLHTLADELLRNLQRLREMEDDERPILFIGHSLGGLAVKMALVKASNEARYENILRQCYGVAFFGTPHQGSSYFSLPSLACSIQSLLQLSSPLPPSVTHHLRVGNSVLTRLDEDFKAASNDLQVWTFYETIDSRLSGGNATAGPDSRDVDFTAPLTSMKSAILGMRQERIFPLQSDHANMASFGRHNVHTLQMFLKQLAHQVCHADTNARAKESSGQWTLELEQKVNVEVHGFFDDAPPSQGQHGDDDMDGPIVRAWSTRVPLREFLTKGPDECLSERLNEVEGSPEEERASRHRGRTPLADKASETAPVPPAAPNLMTVHNALGIRDALSSAGLVPSPASPMDSCSAGHAAHSAPAATPRGPKTPPSRAISPKSSPIRRPSPLIRADREQELAVDRLSAPLRGRMGGRAMSRSFSLGSDGSRFEDRDLAPFSPRSRSSIGDVLASDDEDMELPRLPGAVAAREVVDEAPGAFMKPDVRSRKFVWVHVPFNNPTWVKSVLQSLEASYSEDYSTLYGQDFWMTRHTRGRHAQHYAHYAKPGCYFSAPRALSPRHRSLGNQSLSPPLGSGDSAYTCLFLPYLHFDSYKKLLRRRDTITQRLSQGRAHPVPETVAKSDSLEVQVIWEYLGHDPPINCRRTLDQYGYPSLRDTRSRDDDQMLYKLTKERTPAPDAKGFALNKQGSSNAAISESGRSERSSGSSWRERLFRRDVNDDEDRVLNGNVLMVDQLWLWVIQSHTVVSFFPRRESDPIEGPLYQQADLRDSIFNEVNVDLTRQCENALDLAALAALHAVSVLLDRPSHPDLEVFRIFEEAISVLVSPPPFPASNQAPSLIRQTERLTSSLKEFRSQGFRDKALDHSPVQDGARTIRKRHKEEGRRAERDNRDNTSALLELRDMEDELQTLLHLFERQSRVAASMHAAYSRPELRERAANGRAFLAEALARLREYARQAGDMARRARSTRDDYDKLLSMAQRQAQVDEVRLSRLHADLASAQSRSVMIFTTFTVIFLPLTFFTGLFGMNTREWGGENNLSLETIGMIAVPSSAVLVLASLVVAFSSSARRFFRWVDGRYRHAARRVYFEIWGPVVVRLVDLGGRLRRRSKGGDEEGPRRRRRLETEVSDFWERNRPEREGGYRIPEVNRRRVRVGDATGTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUF6</accession>
    <name>A0A7D5YUF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Beta-glucosidase cel3A</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-D-glucoside glucohydrolase F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cellobiase F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Gentiobiase F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Gentiobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Probable beta-glucosidase F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">G6M90_00g019730</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548570.1">
        <property type="nucleotide sequence ID" value="XM_014693084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUF6"/>
    <dbReference type="GeneID" id="26238014"/>
    <dbReference type="KEGG" id="mbrn:26238014"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028802214" description="Beta-glucosidase cel3A" evidence="19">
        <location>
            <begin position="22"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="767"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI64325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="862" mass="94395" checksum="F7780F6DBC7DE8A0" modified="2021-02-10" version="1">MVSTKLESALLVAAIATGVIGRPGSGASPANKASPEEFLHSRNLPDGYYVPSYYPAPYGGWISDWQESYRKAREFVASMTLAEKTNITAGTGIFMGSAPRVGFPQLCFNDGHNGIRQADNRAVAIGKEARGKGVNVWLGPTVGPIGRKPKGGRNWEGFGADPSLQAIGARETIKGVQEQGVIATIKHFIGNEQEMYRMYNPFQYAYSANIDDRTLHEVYMWPFAEGIHAGVGSVMMAYNAVNGTACSQHPYLINALLKDELGFQGFVQSDWLAHMSGVASAIAGLDMDMPGDTQVPLFGFSYWMYDLTRSALNGSVPMDRLNDMATRVVASWYKMGQDNGFPETNFHTLTRDSVGMLYPAAFPDTPSVVVNNFVPVQDDHNEIARQVAQDAITLLKNNGNLLPLRTSQSLKIFGTGAQTNPDGPNACADRNCNKGTLGQGWGSGTVDYMYLDDPISGIKTRAQDVQFYDTDSFPDQIDQPKDTDVALVFITSDSGENTYTVENNHGDRDASGLYAWHHGDQLVKDVASKYKNVIVVAHTVGPMILEKWIDLPAVKSVLVAHLPGQEAGQSLADVLFGDVSPNGHLPYSITKKEEDLPESVTKLISAPNIHQHQDTYTEGLYIDYRWLNKNNIKPRYAFGHGLSYTNFTYSNATITKVGQMTKTPPTRSPKEGILDYTQPIPEPSEAVMPDGFHKHWRYIYSWLQASEAKNAAADVKKKYPYPSGYSTAQKPGPRAGGGQGGNPALWDVAYKLSVVVTNAGLDHSGKASVQAYLQFPKNITYETPIIQLRDFEKTEVLRSGESTTVELQLTRKDLSVWDVVLQDWVIPVVDGGYTVWLGGASDDLRVSCHVDGMKCQSAATSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVG5</accession>
    <name>A0A7D5YVG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intradiol ring-cleavage dioxygenases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g080430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539374.1">
        <property type="nucleotide sequence ID" value="XM_014683888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVG5"/>
    <dbReference type="GeneID" id="26247818"/>
    <dbReference type="KEGG" id="mbrn:26247818"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03457">
        <property type="entry name" value="intradiol_dioxygenase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF1">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028888103" description="Intradiol ring-cleavage dioxygenases domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="113"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="340" mass="38177" checksum="E035EF73250D3D34" modified="2021-02-10" version="1">MHTFSLLSLILACRLAAGHPGEDHAAELKARGEFLQNHVTNLDHCAQELEASGVMKRGIQRRLHMVNRLREKRGLEPQRDDKQSRDWGAMEASHASLFKTTASCVLAPEEMVGPYYVAGESVRSNIVETQQGIPMEIDVQFIDATTCRPVEGKYVDVWQANSTGVYGGVINRENGNGPADPNNLKKTFLRGVQKTDNDGVVKFSTLFPGHYAGRTIHIHVMLHPNARPYPNGTIIDTTAAYVGQMYFDQDLIYSVENLHPYAQNPNPLTLNDQDFILRQDLWQGGNPYMQYKMIGNRLEDGILAWLSYGINPAKRSRVTPVATRKGNLPRETTDMQRNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVU7</accession>
    <name>A0A7D5YVU7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987062.1">
        <property type="nucleotide sequence ID" value="XM_066130925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVU7"/>
    <dbReference type="GeneID" id="90967925"/>
    <dbReference type="KEGG" id="mbrn:90967925"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13410" checksum="1F3F30CB6ADDE549" modified="2021-02-10" version="1">MEAADLVEELCIHQLNRAGAQNKAIFQDNHTARQRLKTWQATTFRTDDGRAVSGRQIVAKATRRLQEFYDRRSPLPNHAPVCWPFVDFLNGNQTYAKRLPKVFREICRISGERIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWE6</accession>
    <name>A0A7D5YWE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">abcB_1</name>
        <name evidence="15" type="ORF">G6M90_00g020810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548466.1">
        <property type="nucleotide sequence ID" value="XM_014692980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWE6"/>
    <dbReference type="GeneID" id="26237910"/>
    <dbReference type="KEGG" id="mbrn:26237910"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="233"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="556"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI64083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="799" mass="87466" checksum="BD120069E414D923" modified="2021-02-10" version="1">MAGEVPLKSGTIETRQRSLAYCDQTPWVTNVSVKDNIIAQSEYDQQWLATVLHACQLDVDVSAFPMGVATIVGSGGVALSGGQKQRVAMARAVYSRKTFVILDDVFSGLDNKTSRAVFQRLLGSGGLLRNDGQTVVLATNNVSFLEAADYITMLEKGKIVRNQVQYSAFDQQDWGINQDETESDDSSFEVDGNESSRHAKRREADRAQAMRHAEAELSRQTGDIDCYKIYLKSMGLPVVTATLILVIITVAADKMPQIWLRLWTQHGTTSTSDNLSYMGGYVAFIVLAMIGGVVNIAFFAIIGIPKSAKRLHAMLLAAVIQAPFHFFTCTDNGLTLNRFSQDMSLLDQALPFAFIATVAAVVQAIAETAIIASGSSYIGAILPVCFVAVYLIQHYYLKTSRQVRILDLEMKSPLYTHFTETLAGLSTIRAFGWTMAVKEENLCRLNTSQRPYYTMFCIQRWLQVILDLFTAGMALVLVTFAVMFPWTTSNGAIGLAMVNIISFEFTLSMVITQWTQLETSLGAITRLKWFIKNTPSENKLQENQEPPPGWPSRGLIELDNVTAAYKDGADPVLLGVSLTIAPGQKVGICGRSGSGKSSLVATLARLLELQPGSTIRIDGVNLATVPRQTIRSRLISLPQDALRLAGTVRHNLDPEQSIQADEALIEALTKTAIWPYIEAKGGLEAKVEDLIFSAGQLQLFCLARVVLRHGRAASRGAVILLDEATSSVDRRTDDQVRDAISANLDGRTVIEVAHRLDVIRHYDVIVVMAEGRVVETGPPDELLAQSGSEFAALWASRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYI4</accession>
    <name>A0A7D5YYI4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pm20d2_0</name>
        <name evidence="4" type="ORF">G6M90_00g053410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540465.1">
        <property type="nucleotide sequence ID" value="XM_014684979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYI4"/>
    <dbReference type="GeneID" id="26246827"/>
    <dbReference type="KEGG" id="mbrn:26246827"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF8">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="446" mass="47725" checksum="772E8ED299281298" modified="2021-02-10" version="1">MSPVTVDTVTQARAIVNARLDELDDGLHQVNRTLHANPELAYKEFIAHDTITAYLEKLGFQVERSAWGLATSFDATVGSGDRQVIFCAEYDALPEIGHACGHNLIAISSIGAFLGAAAAMSALKIDGRIRLLGTPAEESGGGKQDLVEAGAFNPPESVVAAIMAHPMPIEYVSQGGFSGLAGMKLIACQGTLVEFKGRTAHAAGEPWKGVNALDGAVAAYNNVSLLRQQMHTEDRVHGVFEVGGTAPNVIPDYTRMNWIVRSPTAAGCDKLMERVTKCWEAGASASACEMKTTRFVRSPFLLLPSCSYLLEGAKKKLLTLDIPNRQHHYLNLRANDSLCQIYVDEMAAFGQNIHLKIDRALNASTDMGNVSHFVPSFHGGIGIPAEPGVAMHNPRFAAAAGTDEAHGAAIQAAKGMAMLGLRVLLDSKVAAQARLDFERDDEEAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z046</accession>
    <name>A0A7D5Z046_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g008900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549621.1">
        <property type="nucleotide sequence ID" value="XM_014694135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z046"/>
    <dbReference type="GeneID" id="26239065"/>
    <dbReference type="KEGG" id="mbrn:26239065"/>
    <dbReference type="OrthoDB" id="359154at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42800" checksum="EE434D1874FC108B" modified="2021-02-10" version="1">MQKLVKRTAQAQRQATRRARQQMEQDNIDNRMRNRQALRSAVYEIRQNLKDARQARREDWEMGPLAPKRDLGFNNYGAFKETVRQDWTNYGLHQARPQIIEHRCAWAGGVRQLNLAPQDRVVIMDGPDKGKIDRIKDVQAENGTVTLENRHRALSVGMFDNPARSQAMPISVGSIRLVYPLRNPETGVTKDVIISQLKAVPPNMQSSNMSLDRWQYGKKWDRLVAGLNVVIPWPEVQVPEFEATKADTVREQAEERTFYYGLLSPPMPDQVLDELRNKYSRFRTRHEPWYIQQKEMEEAGKKGRLEAIESMQTPLEEFHERQRELRDTQGEPELSEEMLEKIGEYMAKKKDAALHQAGVSEVSSPQAPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z052</accession>
    <name>A0A7D5Z052_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nop-16</name>
        <name evidence="9" type="ORF">G6M90_00g062440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986712.1">
        <property type="nucleotide sequence ID" value="XM_066130741.1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:1990904">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
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    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
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        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="271" mass="30382" checksum="AEDC33386440AE0F" modified="2021-02-10" version="1">MLEASHGQNLHFCAHGLIDRAPFRNFGSKLPNLSRRNLSTTNQILPNRTATMGRELQKKKRRSNRQPIKQSNKTKKILNPRGNNIIAKNWDKKETLAQNYRRLGLVARLKAPTGGVEKKLGATTTGISKNDPFAITSVGKAIISEAKVERDADGKIIRVLGTTRPNPLNDPLNNLDSDSEEDGAGEEWGGIAEREAEEEDTTDVVRSLIEESHNPAPKVARYQSEGEREWLEKLVEKHGDDYGAMARDTKLNPMQQTARDIGRRIKKMRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0J1</accession>
    <name>A0A7D5Z0J1_9HYPO</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="8" type="ORF">G6M90_00g009820</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014694048.1"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF55">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="181"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="245"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="408"/>
        </location>
    </feature>
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            <end position="434"/>
        </location>
    </feature>
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    </feature>
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        </location>
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        <location>
            <begin position="71"/>
            <end position="578"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="589" mass="64007" checksum="37D2329969059CD8" modified="2021-02-10" version="1">MVSAVNSQVGTQPRAYAALDSDESSSLLSDHDVDRNDDGNEDAIRASDIQSGVQDVEAMTVAWTTSALVFAYVMIWLTYFVEGMLTGTTAILTPYVTSDFARHSLTPTVGILSNVIGGVTNLTLAKVLDVFGRPQGYLFCIVVAVAGLIMMTLCRSIQAYAIAQVFQVVGNNGILYSLTVFVADTSSLRNRGLMQAIVSSPNLITCWLAGPISSAFLNGSSWRWAFAMFTILVPSITLPLFGLLWTNFRKAKDLGLVAKGDSESDRTAWESLIYYSRQFDAVGLVLLSAGVAVLLMPFNVYALHGWNSPLVVAMLFIGLLLIIAFAIWERYYASITFIPFPLLLDRTVLGACILSATLFVSFWCWNSFFSSYLQVVNDLNVENASYVVQSYTVCSVLCGIMVGALIHCTGRFKPVCLYIGIPLSILGSGLMMYFCKIESSVGYIIMCQILISIAAGTIMVCDEVAILAAASHQHVAVCLAVLGMFGNIGGAVGLTIASAIWQSVFPNKLREYLPLEELPNLEKIYANISTQLSYPVASPARLAIQHAYGDAQMRMLAVGTSVWVVGLVSVMIWRDINVIGIKQSKGHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0J2</accession>
    <name>A0A7D5Z0J2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0J2"/>
    <dbReference type="GeneID" id="26238143"/>
    <dbReference type="KEGG" id="mbrn:26238143"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="34446" checksum="9C95D67E7A7FE1BE" modified="2021-02-10" version="1">MQNQANRGLQREAISAPGAKKMAMSPPWSPDQDEVGRSWKESVKCRDHYFSGNLDDVDGSLTVSRRPMMDAYCLFFLGIGGRNTVQELRKAAEKRTGDMYIRRGFNAVYHEEFEFFVDKLTWEKYFGRWGETRKVRWPWPTTVNSLKAGGLSLTYDRLLEASRQDNPSVSLSTPMEQSIASEKANTPQIETQPKRHRLSSRKRHRVPTSSEEAGSSNTGSGQIAPADDLLAQVSYQKLEESLASINARLLQIEAYPKDSRPSSSRHTIPSAPEDVRRIMCDEGYPELIEYLVEVEKRRKKPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0U5</accession>
    <name>A0A7D5Z0U5_9HYPO</name>
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        <submittedName>
            <fullName evidence="6">Serine/threonine-protein kinase/endoribonuclease IRE1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IRE1A</name>
        <name evidence="6" type="ORF">G6M90_00g016750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238299"/>
    <dbReference type="KEGG" id="mbrn:26238299"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1347"/>
            <end position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1385" mass="155385" checksum="C45EC8F127CC804B" modified="2021-02-10" version="1">MTSQEPSHSNVGFAQREHDILSLLSIFVHTHQTLSIGFRLLGIVLDDQSFYMPAPVKEGGYFEVYILRSKDILEADLLGSKEDIPSNLPRTVAVKCPKVRGKLNDRRNQKLWTSMAMELQILKHEHVKNHDNIIKLLGLSWRSVRGTYMPAFVLEAAKSDLYSMIQSFQFTLDKMTTRKILGLAVDISCGLSALHDLGIIHGDMKPQNVLIFEDQKLGFVAKITDFGSSLLKTDIKEPIVLPYNTDIWQAPECQNALDGSQLIEADNFSLGLVLCYMLSRGLILHQLEESDEKAATDGQSAVSYDFYAKVAAEALHETFRPALEIEEERLYGPMSSRKPEGWPDPNEKVDNLDEDESYVSIRKIQRAVARTLLPSLFEPPMRPSSKSIYLNMRVCFSWLLRRDTFYPILSLHDPFTPERLKAANFNDQERDVLQNPGAIATKEDKERVWKYATTMEWLDRSIKTIQQGGDLPSMDDISQSDAAHRIATSLKTWTQSEAPPRNNMREVRNPFAVVEAEASFGTMRCIPACVLNQILGEMRAVACNERESESRRAEAAWQCSIFQTMAAQLDQVDNPGISPTLELMLLAASLGNWKAQSICGWLHSVFDRPFPVSEAVELEWLHDSICKGSATARRRLESLDPGAYTIAVDDLKRCWAGIGVNLPDDWQIYDDIDFLGLLEDQPCLVGDYLQIAATCGRLSLLRTILNKYSSIIDINARYPGDETILLKACRSGHFEVVLCLLDQDADASICSEDGAAPLHFLSAFEEEQIPLVANRLVAAKASLKARSKNAKLYKLAVDATFGMVDGTPLTWAVAANNHAATQALLDLGSDPFDIAGRTAEYGDSWSNNAHISPVWTAAASFQYELLEMLLKRAGDCAEHLNYNERTFGTQGLKDPFTILGWVVNGCEGHGIRRLLLHEKQFSQAFQRTFDLLLQYGADPSIVSVEGLSFIRTAIQRGQPYIIDHLMTTRGGMFKPTASDWSHCVLIALALQDNSTLRVLLRHSQAEALDPDHWNKFFASTKALPDDSEMLDHFRKYRDSNLDMLPHCGNALLAGKYKLAKWLYQTGKCDLTTMENDKTLLGRLITASKVYRNASLHIAAFLSLNPPDEVYYNVIDLLGSRLTALQAVVYIQEYRHGQMATTDILQAILRKKTDTDYLNLRVEGGPWQGKTALHLAVESCNVDAVQYLIDAKGQYLDLSALDGNGFSLIDHAALLMKNQKSNMDVWEVPSEKRRDVDLRHFENTLVIMRLLYRTKRAKPNKLALSLTRVEVDELQVILYGDEEQLVIPCKIPDLKRAIESGQYNCDDWPESSNPLRRQSVMIFQVLRDYGLKLGVNDSVFGYTDTVKPAAGHDSGGEQSLVSDPGEQRDGQEAYSEFVNSVKKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0X1</accession>
    <name>A0A7D5Z0X1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g112590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987969.1">
        <property type="nucleotide sequence ID" value="XM_066131862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0X1"/>
    <dbReference type="GeneID" id="26246920"/>
    <dbReference type="KEGG" id="mbrn:26246920"/>
    <dbReference type="OrthoDB" id="4939946at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028947854" evidence="3">
        <location>
            <begin position="29"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="420" mass="45394" checksum="BBA5F607169273DB" modified="2021-02-10" version="1">MAGKVFFRKSTICKLLFMISTLVANAKAEDALAKFGDVIPVLGQMARTDQDFVDGLALDLFSPRNRTLVVTNNSSPLPGTFVTGTTGEGFVNLSKYSWVVKLNETAEDLIAKIELPYDPVALAGQSVQVANTYVGKLAKDKKSWVISESQRNVHMTENKTRIIKMTSLDGEYMLLGRKSEDTSNIFVQYGQGATRTVNITGGAEKIQEAEFVDGLRFRVQSAKSFALNADIPFGVNDKAMPEHAVPLNSFAWVINSTASPGEGLSVDVHFPVNREMVEEKTRGQEEGHLNLLVARRDLKAPATAAFEPLKKQEYSKAKRLVEVRGMTAVDGQYVLLVSKKKYLEASCGQGGNAQSCPGRNSTSASAGAASQARESELDGAQVTSRPAMVVSVASLSTAWGMNLVVSCVFSMGVSLVVFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Y1</accession>
    <name>A0A7D5Z0Y1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase 9 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuo9.5</name>
        <name evidence="2" type="ORF">G6M90_00g002070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542874.1">
        <property type="nucleotide sequence ID" value="XM_014687388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Y1"/>
    <dbReference type="GeneID" id="26244247"/>
    <dbReference type="KEGG" id="mbrn:26244247"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8287" checksum="11C95E5D63C7E1F8" modified="2021-02-10" version="1">MSAPVFWSTPLKYCRWAARERPALFWSVIIGAAGPIAMPIVPPIRKYFGDADPAPIPVTYPVPTGPRKQLTGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1A0</accession>
    <name>A0A7D5Z1A0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-reducing polyketide synthase ausA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ausA</name>
        <name evidence="5" type="ORF">G6M90_00g031410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543080.2">
        <property type="nucleotide sequence ID" value="XM_014687594.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1A0"/>
    <dbReference type="GeneID" id="26243881"/>
    <dbReference type="KEGG" id="mbrn:26243881"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="479" mass="53418" checksum="5D41A18BBE094177" modified="2021-02-10" version="1">MRHDTPAMIDHRLSEMEVTEAFRDAIVIETGCDIGHSDINTDFSDLGLDPLAALNVLNTVTNRTGIELPASLFRDCKTLSDISKHLGQKQGISGSTSATQQLSSQAEQPVRDAFLELSSYERKFAEEAGFANFWRAVYPAERRLVLSFVYKAFSDLGCALDKVKAGQKVPCPQGILDKHRRVFDGALFEILEDGGIVSESPAGYIRTPTPIDTTPSEDIYKDLVRDHPPFAKVHELLHVTGSRFAECLSGKSDPIKLLFGKNKDLLQHFYTDAPMCLAASLHLAALIQRVYTRRARRDDECIEILEVGAGMGGTTKFVIDALVEANVRFKYVFTDISSSFFAAAKRRFGDIAPGSMECLVLDIEKEPPEPLQRRFDLVISTNCIHATKSLVTSCSNVHRLLRPGGFFALIEFTTRYYWLDLVFGLLDGWWLFEDGRKHCTVNGPSWKTNLEASGFSHVLWTEAEGIEKPNPQLLVAYTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1B0</accession>
    <name>A0A7D5Z1B0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g028330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541328.1">
        <property type="nucleotide sequence ID" value="XM_014685842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1B0"/>
    <dbReference type="GeneID" id="26245963"/>
    <dbReference type="KEGG" id="mbrn:26245963"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="328" mass="36232" checksum="6F6089496CB851B0" modified="2021-02-10" version="1">MVSHGNYKVQKVTYPSNGETIAGILYKPTNVSNPPGVVLLGPYSFIKEQAPLQYATRLADEGYAALIFDPRTVGESTGQPRRLENPKMKNEDVVAGLDYLQSLPDVDSNRLFLVGICQGGPECLDIASYDQRVRGVASVTGYYRDRETDIWMICSGCVNPEPGVDVGSMKMPTQEQGEALYKARLERARKARELYDKTGEVVYQPLVDPKAADPEVGSLAGLPGPVAWSWYGPWTLKNFDNRYAVMSDVDHFGYSTVDGVAKLTKPALIIHGDNCMNAASAKRHYDSIPTKNKKLVWDNGVSHFQHYEQPDIVDHNVAEIAAWFAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2B8</accession>
    <name>A0A7D5Z2B8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541154.1">
        <property type="nucleotide sequence ID" value="XM_014685668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2B8"/>
    <dbReference type="GeneID" id="26246143"/>
    <dbReference type="KEGG" id="mbrn:26246143"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="365" mass="39796" checksum="C9EC558FDBBEF351" modified="2021-02-10" version="1">MTTYSTDPALYIFTSLTAGSSHIVTATSRLETILRANRIPFKAVDIATDEKARMLWGRRAGKDEGGRLRKLPGLVQEGLVLGDLVEIEDWNEYGELKQHVKIYYDEHTIPNIHNKPPEPAKPSKPAAKPAAASNTTVAPKAAPPMPEPKSGPEAATKAKHGPAESGKETTLPMRAVADEAAQKAKELNLKSLREKVHGTRVNDGSLESSSETAIADSKSRTEDGEKTTDIKEQKPPGLQSPTSTAWKNKSGEDALRETVQSPTSGRWRPNSVDAAGVKTHNGARVVAASPEEIKQIEREQKIKEEPELEGGDEEKDKVAQKGKDDLKDGAKKDESKENEDGDNEDDEGENEKERKRSEKAEKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2G6</accession>
    <name>A0A7D5Z2G6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptojanin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Synj1</name>
        <name evidence="3" type="ORF">G6M90_00g048250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544940.1">
        <property type="nucleotide sequence ID" value="XM_014689454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2G6"/>
    <dbReference type="GeneID" id="26242281"/>
    <dbReference type="KEGG" id="mbrn:26242281"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="975" mass="108149" checksum="A357B8C42A14B734" modified="2021-02-10" version="1">MAAPESPQSTHSGSFEPVDLLTEPQSLARAVHARRPEYLRPHKIRVKIGTWNVAACTGTDKDLERWFVGGQGIDKHFATLDLSRNPAVAHPDSAGDEDDPDAVRLLGGNDIGLYVLGLQEVVDLNATREYMNRAVNVDSSPVGKWQAALEAAMPPGYQRIMSEQMTGLLLLIYASPEVAPTITNVSTKQVGTGLLGYFGNKGAVTSRLVLGETTRMVFVNCHLASGAGSSYLDRRCWDVDQILAKTKFDPVVHAGVSEDDGETIGDEDFAFWFGDLNFRLDGLPGHDIRRLLTLHTRGEYALGDDHTPRPPEGEGIIVMRDSESDDDTTMRSSLHSRDQSFDSETTLPDPGDFPEDPSQDPTSLQATLDSLLPHDQLRRMIAHRKVFHDGWREGPITFLPSYKYDVGTVGLFDSSEKQRAPSWCDRILYRTRRDKQAFDAKLAEEIAAKKKDEEMKSRGIDEDDDVLFSYDPDTDGDEQAEVAAYDYDEYDEAQDDIPREVVTKEGYVDRIALDIYTSHQRITSSDHKPIISVFSLEYDAVVPELKAKVHAEVAWELDRAENEGRPAITIAMEGGKSGNENTVDFGDIGFLERKSSVFTVANTGSVPASLLFIESPTTDEVDSTSLTWLTTSFLHPDDDEASDLGKEVTLEPGETVLAHVQAQVSDISYLRALNDGHAKMEDVLVLRVEDGRDHFIPVKGVWLPTCFGRSIDELIRVPDGGIRKFLAEKDIKGAIPYDSDIRCSAPKEIFKLTEAIQTLVERCVADEAMLESMTLPREPGWPFDSSTWTPGLKEQDETKADLVAALDNDSSITEVLPVELSSPHKLELLSSILLLFLASLTDGLVPPILWAKLSTSFPNLTSLAPTAWADTKMHILDIFSSAPNHNIAFVFLTSTLARVATELSPATSEPLLPGLSRRFNFRRGEDDSEKKRKLRERKYAEIIAPLVFRTNDRDKTVKEKERIVVEIFLSREAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3E6</accession>
    <name>A0A7D5Z3E6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g003820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985957.1">
        <property type="nucleotide sequence ID" value="XM_066129558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3E6"/>
    <dbReference type="GeneID" id="26245067"/>
    <dbReference type="KEGG" id="mbrn:26245067"/>
    <dbReference type="OrthoDB" id="2338662at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028813469" evidence="1">
        <location>
            <begin position="17"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="565" mass="62847" checksum="72E96EF9337E07E2" modified="2021-02-10" version="1">MRVFTIFGVLIGLVVAQETGNHPEWQRWCGKAYQPQHPSFEPGGQTVEPDKLPGGPALDIQFKPRYSIYLESEKQAEFVVNAGISKWHGQPWPSLSTPGAAPRVVFTINLVSNNDLLVSDSVNVSTTGNVFAFNLSNLQPSLDPYEVVLFGATEDGASNVTVTSELMFLPEKTKGSVAKLDNLNGGFLFRSPATGNNFEPFLPYGYYASCDRFLCDKDYIQKVKAYKDLGLNSMVSLTTVQNSRATYEYMDTLDLRYMYDLRGSYKNLTAVEEQVSVIRDFEGLYSYWGADEPDGHQDPFDLLPEARRLIRQLDPYHPVSVTLNCQNFYYKEYTAGADFVMEDAYPIAINSTFSKWGTPCNTTYGDCGCDNCQGNVQDVPNRLDDLLQYEHWLGLWPKTKAHNPQAFHGEDYWFRDPTNEEEVAMNALGFNHDAKVIASWVWPFSDSLGQIMGKFGSAVANQPARDLIVTGKAKRVHVEGHRVVDAAYWAGETQVLVSVVNGGYEAIDGEVSIPLPKLFALQTKDAIVWGNGTWALGDGEVRLSKQSAMATNMIILGVGKGKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3X6</accession>
    <name>A0A7D5Z3X6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isonitrile hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">inhA_2</name>
        <name evidence="3" type="ORF">G6M90_00g078950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545215.1">
        <property type="nucleotide sequence ID" value="XM_014689729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3X6"/>
    <dbReference type="GeneID" id="26241248"/>
    <dbReference type="KEGG" id="mbrn:26241248"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="211" mass="22870" checksum="434820DA008E0ABA" modified="2021-02-10" version="1">MKSPNKFAVLLFDSFQALDVFGPLDVLNMLAMNNTLELSIISTSLDPVTACTGPSIGQNILPTHDLHNSPEDIEVLLVPGGRGTRDTGLTQPHVDFIKSRYPKLQYLLTVCTGAALAARAGVLDGKKATSNKAAFEWVKTQGEKVDWVPGARWVKDGTTWTSSGISAGIDMMYAFIADQYGENAAEEIARRSEYVRNTDPSNDPFSKSMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3Y4</accession>
    <name>A0A7D5Z3Y4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase I subunit RPA43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPA43</name>
        <name evidence="5" type="ORF">G6M90_00g080020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539522.1">
        <property type="nucleotide sequence ID" value="XM_014684036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3Y4"/>
    <dbReference type="GeneID" id="26247686"/>
    <dbReference type="KEGG" id="mbrn:26247686"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="4">
        <location>
            <begin position="279"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="457" mass="51313" checksum="D39FE3FF1F237A25" modified="2021-02-10" version="1">MSTAASPEPATPKHEKKTKKEKKRAREEEVALVEGERKHKRSKSITADAIAQNNDIHGQDVNKDKKKKKEKKNKHRHDAGEEAEEAHKHKAEKKKKKHHKEQTETLTHAEVKAELGDDELKPEKKDKKKKKKHAEVADEAVETVISKKPKPSTQLTESEDTDAMDIDKPSASVYQPPDIPADPQFPFFEQTVSLYEPLYPNGWAQPITSCQYQHLQHLQNKYVPSLRGVLLNYKNVALGPRPGRDGAATDDETPTTVVSQNEYAVGFGWITADVELFVPSRGAWMEGSVNLQTEGHIGVVCYGKFNASVEARRLPPAWKWVSNESPEAHGFEETASVITADDHGVVRQIHSTGFWVDGNGDRVKGRVRFRIRNFDAGTSGETSYLSLEGTMLDKDSEKKLVKEEARTAQMRRYKKGGRGIERRRAPDFSMTRFVDVEVDKDGQQAEAETGGETTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z465</accession>
    <name>A0A7D5Z465_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cbr4</name>
        <name evidence="6" type="ORF">G6M90_00g071400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987140.1">
        <property type="nucleotide sequence ID" value="XM_066130953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z465"/>
    <dbReference type="GeneID" id="26241952"/>
    <dbReference type="KEGG" id="mbrn:26241952"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="29741" checksum="CFD9794B9E9A130C" modified="2021-02-10" version="1">MIPLAGKHAVVVGATGTIGAHIAQAFAAQGAVVSLLGRTALQARAKLEPQLTPYTASHGQNSPSDTPTSHRFIRLDVADRASIKHVFDPRASQVSVAVVARFRHGRGVKAYQRAKQHAEAVGPLDVLVNCAGISQTTLLKRTPDEELASILDTNLLSTMLVCKHASVRPNGCIINVSSLMATKSGLGVTAYSASKAGVVAFTRALCREMAARSIRVNALLPGWVQSSMWDHLKPELQQAYLKDTPLNRVAHPAEVADAAVFLASNGFANNCVLNLDGGLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4L8</accession>
    <name>A0A7D5Z4L8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g054530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540951.1">
        <property type="nucleotide sequence ID" value="XM_014685465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4L8"/>
    <dbReference type="GeneID" id="26246257"/>
    <dbReference type="KEGG" id="mbrn:26246257"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="378" mass="42177" checksum="06C87CE09D45D53E" modified="2021-02-10" version="1">MSNSNLFRPIAFGKGVLQHKIVLSPMTRFRADDNGVPLPYVKTYYSQRACLPGTLLITEAVAISPRAKGFPNVPGIWSPEQIASWKEVVDAVHSKGSYIWLQLWATGRAADMDTLKANGLELVSSSATPVGPDEPTPRALTEDEITSYIADYVQGAKNAVFGAGFDGVEIHGANGFLIDQFLQSSCNQRTDGWGGSIENRSRFGLEITKQVIDAVGKDRVGMKLSTWSTFQGMGTMEDLVPQFQHFLTHLAEMDIAYVHLANSRWVEEEDPTIKTHPDIHNETFVRMWGDKKPILLAGGYDADSAQRVVDETYAKQNNVMVVFGRHYISNPDLPFRLKMGLDLEKYNRDTFYIPFSDEGYLDYPYSEEYLAQEQGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Z9</accession>
    <name>A0A7D5Z4Z9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">abh1</name>
        <name evidence="12" type="ORF">G6M90_00g035890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546984.1">
        <property type="nucleotide sequence ID" value="XM_014691498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4Z9"/>
    <dbReference type="GeneID" id="26239547"/>
    <dbReference type="KEGG" id="mbrn:26239547"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="11">
        <location>
            <begin position="229"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="365" mass="41200" checksum="A4B127BBE5527750" modified="2021-02-10" version="1">MTVSLAELDAHEQPSDEMRAEWKHFYRLDPSVVVQDPRIDDPRLPLSENGFQASGKIDKTQAADAFAALGDHLRSFAQEDIPVISHPLLPGLLIMPNLVPPAVQKDLLAKILHRDLSNPKHQTNLHLHYTLPYSSATCSPPDSDSVPDSPLPSRPQSFFTLSPEVPATFTPKDPTVHKPLSAGQVLNRRLHWVTLGGQYDWTNRVYPDSEPPRFPTDLAQFLEKLFPETAAQAAIVNFYSPKDTMMMHRDVSEEVDKGLVSLSFGCDCLFMIAPNSRAGRDDDKDDKTDGHVQGEKKYLLLRLRSGDAIYMTKESRYAWHGVPKIISGTCPDYLESWPAENGEYAEWEGWMKNKRINLNVRQMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z531</accession>
    <name>A0A7D5Z531_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein SED1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g033020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543231.1">
        <property type="nucleotide sequence ID" value="XM_014687745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z531"/>
    <dbReference type="GeneID" id="26244032"/>
    <dbReference type="KEGG" id="mbrn:26244032"/>
    <dbReference type="OrthoDB" id="4941543at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028927824" description="Cell wall protein SED1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="40377" checksum="AA2D5FE6786F8A5B" modified="2021-02-10" version="1">MKAVFVVGALAASAAAHTYPNCEHDNCYRALIKDGLQDKAKAFCFDWLAGTTTAASAIPTDFSNCNVQAASSACSCVTYTATHTTGPTTTSTPPPVTTTTSEKPPTTTPTTSEKPPTTIPTTTKTEQPPTTTPTTQAPPTTTATTEKPHTTSQSTTKWTTSTIYTTKTNTITSCPPEVTKCPGGGHTTVVTETIPVSTTVCPVTETEAPPTTTATTKWTTSTIYTTKTNTITSCPPEVTKCPGGGHTTVVTETIPVSTTVCPVTETHAPPPPPPAGNQTSTLYTTQSYTITSCPPSVPSCPVGKVTTTVYPTGTTTIKGWTSIPAVPTQPTGVPPVPTQPTGVPPVPTQATQPTGVSPSKTNQNPPPVVTAAAGQLVGSLEFVAAAAGLAALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5T9</accession>
    <name>A0A7D5Z5T9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin fusion degradation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UFD1_0</name>
        <name evidence="8" type="ORF">G6M90_00g040810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547429.1">
        <property type="nucleotide sequence ID" value="XM_014691943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5T9"/>
    <dbReference type="GeneID" id="26239992"/>
    <dbReference type="KEGG" id="mbrn:26239992"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="7">
        <location>
            <begin position="164"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="6">
        <location>
            <begin position="264"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="5">
        <location>
            <begin position="646"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="757" mass="83446" checksum="80C0DD59DDEF0905" modified="2021-02-10" version="1">MNEQPALRWSGSFGVLPTTAASVKNLSGDKIILPQSALEQLLNAAPSQPTTASSFTAWDPHNPYRSNGFGFEQRQQLPQPLTFRLVNSQNGNVVFAGIREFSAEEGTVGLSSFLIEALGIEPQQLNATNGNRTSDADAIDLTGDHVPSTTASIKLTVDATNIPKGTYVRLRPLEAGYNPDDWKSLLERHLREHYTCLTKNSILSVNGVKGETFKFLVDRLSPEGDGICVVDTDLEVDIEALNEEQARETMRQIMTKAQTEVVGGVSKGGDLDIWKDVSGHVSPGGYVDYILPSWDRSQPLTITLSGIEQEDGVDLFVTPKSSRQRVLPRDSAHVFGDFSPAEDGVKSITMSPTNVEMEGAEAILVSVHGFSSENQRTSQPIPFTVRAKVGSPTSKAGQDRMEVDGEEHSSDEEQCSNCKQWVPKRTMALHENFCRRNNIPCPYCSAVFKKDSNEWHSHWHCEHDSAKGNSAASKSKHDMIFHQHHPCQDCEFTTNSLADLARHRTSVCPGKLILCRFCHLEVPQEGDPFNPSPEVVLSGLTAHELADGARTTECHLCDKIVRLRDMETHMKHHELDKVSRAKPEICRNVNCGRTLHGVGPRGQIGAGTSQGQGPGNDIGLCSLCFGPLYVSMHDPEGKALRRRIERKYLGQMMTGCGKSHCANEWCRTGRKNTNAEAKGSSASAVLPLVKPLLAMVGTPDGHMYFCVDETNQKRRKIAEMLAAEKLWDLEWCVAAAEAEKGNIDRMRDWLQAWAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z685</accession>
    <name>A0A7D5Z685_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g033710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543298.1">
        <property type="nucleotide sequence ID" value="XM_014687812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z685"/>
    <dbReference type="GeneID" id="26244099"/>
    <dbReference type="KEGG" id="mbrn:26244099"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="571" mass="63912" checksum="49E7DC22F119FB35" modified="2021-02-10" version="1">MNAEEDASSTKTACPTTVIANVLILPDAKQPVHIELSNWDQIDDFLTRDHDEHPGQWKMFILNGLHTKLAFELAVRLDIDPGFFDSHVYRTRYLPPRREATRKEAAKERQGEQNQSNKAAADAGVHFFQLDFPEVEELSIPAGVPTSRSSEIPLLETRWMLDENVLSLAPDARKAYLLDGTLYRWDGVLVGAFGYWRRMSWWSCERQKMSVMIIDGPLEAVLPPYVTPAQRATKPFRNSVRRQGASAVEALDSLYARWRERRRPQTFLERFLGQGGAASSVYEVATEVALQQWHLLLATVQVDRGPNQANYLLEIMAQRVENNALDCRRYTRGAGEAAGAWGDLGRLLPQRRDSAFLQVVTGFHDKFQRLERKLPPPSASRMGALAREVREDRRALDRLSYMGGVLLPFSIVAGMFSMAGQFAAGGGLFFVYWVLVVTGVLVATVLVYADSLRTKKVRREDRGRKRPSRLGWLFGGRRREGGSTTSSDTSSVSGESARGGQGGGRGGGGETGRPPAGMMTPTPWRLGPRTVWPGYGEEVMRADKTEELGWWRALWTLVGYRPVWAAEGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6K3</accession>
    <name>A0A7D5Z6K3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g094030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540767.1">
        <property type="nucleotide sequence ID" value="XM_014685281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6K3"/>
    <dbReference type="GeneID" id="26246380"/>
    <dbReference type="KEGG" id="mbrn:26246380"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="179" mass="19411" checksum="AA3DA3CA3310CB90" modified="2021-02-10" version="1">MGTDPLTAFSAMNTAVPNPKQDHNLFRCSLDIAPACFATGKPCKGILSMASTMDIEEMGNGRQAAELLRLMGNSFQEKDNCGERFIFGYHHKFAAGIYLGSGLGKQTAELSLNTMADRLQLNSKAPNHTTAEHFSSELQAEEPFGISIDTTGDLAAVQRAVLEWREGICATSNKILRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6S1</accession>
    <name>A0A7D5Z6S1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g080110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986996.1">
        <property type="nucleotide sequence ID" value="XM_066131146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6S1"/>
    <dbReference type="GeneID" id="26247678"/>
    <dbReference type="KEGG" id="mbrn:26247678"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="532" mass="59910" checksum="86C38546B28A5735" modified="2021-02-10" version="1">MQSNAPTIVSSGGSSASYVEEYVQVIKSCFSKDSVIGPYFYQLIDYLQSDSTSESRMNPVPSAIRLRASSDLIHQTYAPATQPWGLDIPEKNVTQTQAPCLITIEGLPSPSCVAYLGSKYGLRPEYWLGHLSLGRQSPTHDKFFELPALPSRRGNIVQVLIPFLGRRTGSSYATHVSAIERLQAQQKLEEWDRHLFQNKKFGATRLRKLHLHSSQYFSIEQLVSFTVCTRTPNSWVGIFLVDQGLGVPETQDTPWSKYTRNRQAPDFLPILSYNESPSGYEIQSTAREMSPSTPNPFHPRDHVRVASDKDLDLLRESPFAVLASLLGRAAAGWAQILNFIDSDIDKCKIPGPSPTTEALGSALEQLRFNLDFLAHAEQSLKDNAYLIEWHGSRTWPGHQEYQEATLGAELASTLLLDTQYLIRRCSELSHRCESVSQVLSDTINVSEARENFGQTQKITNLTTLAFIFIPLGFVSTFFGMNVNVFEKNPSIWIYFAVALPFTGSIFFFYYCCFHRRLWRRSQQSLRMASNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z726</accession>
    <name>A0A7D5Z726_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014683844.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247873"/>
    <dbReference type="KEGG" id="mbrn:26247873"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028798076" description="Phosphoglycerate mutase family protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19053" checksum="BA20C78D9E303E90" modified="2021-02-10" version="1">MKIAYILTLIAGVVAAEPMVFLIRHGEKPADDDEPGLSIKGQQRAQCLRSVFGAGSNYHVGHIMAQAYKPDGSRKRPFDTVSPLAQDLGLEVDTSCDRNDSKCVKKVVKNYKGAGNILICWEHKALRDIAEALGADDVKDYPKKRFDEIWIDPYPYSEITDIVSENCPGLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Z5</accession>
    <name>A0A7D5Z7Z5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yml6</name>
        <name evidence="6" type="ORF">G6M90_00g065410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986706.1">
        <property type="nucleotide sequence ID" value="XM_066130803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Z5"/>
    <dbReference type="GeneID" id="26247042"/>
    <dbReference type="KEGG" id="mbrn:26247042"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="33979" checksum="1E65FEB227AB81D9" modified="2021-02-10" version="1">MAALRVSAKPTTLSKSISRSMATEAPARDLTRSANTQSLVQSWNPVSTVPVTVHSFPSLEPTSLEQWSVQHLYLPLRRDILHHAITFEGDNTRQGTASSKTRYEVHGSHRKVRPQKGSGRARLGTRQSPVLRGGGKTFGPKPRDFGTKLNRKVYDKAWRTALSYRYRRGELIICEDGMELALPPDFEMLADKYMRDGLRETYLQKYMTGVLRTLGLGRADGRTLFVTGDPRDRLYEAMEQVPWEGRALDVEDVDVKDLLETGKVVMERSVLKEMIERHQSDLITRIAVGGLAKSAPSTGEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8F2</accession>
    <name>A0A7D5Z8F2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UNC93-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g093010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541945.1">
        <property type="nucleotide sequence ID" value="XM_014686459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8F2"/>
    <dbReference type="GeneID" id="26245413"/>
    <dbReference type="KEGG" id="mbrn:26245413"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49555" checksum="3559000B8A9D4104" modified="2021-02-10" version="1">MSSTTKPEPEAAAVQRQQKVRWYRSTFYNMTILGLCNFAAPGIWGAMNSLGGGGAQKPYLVNTANALTFCPMVVSCWVSSALVHYIGIKGALIFGTLGYAPYAAGLYTNNRFGTEWLVILGAALCGISAGVFWMAEAAIAIAYPEPWNQGKALGYWLTYRLAGQVLGGAINLGLNADKDEAGKVSYTVFLVFIALQASGPLVALLLNQPHQVERKDGKQVDLSILDNPGREILRTTKLFFSKQFLLIVLFIGQAVFAEAVFFTYLSLWFSVRARALGSFLSGIIAVIGGNVLGSWLDRTSIPHKTRARSSFWLIVILQGAWWTWATVLVTKFRYTQPTYDWSSPGFAAAFLVFVFLTLGFQLNYLFLYFIIQNISGDNSEVVRYAALLRGTESAWQAVSYGLSSITIIAQVGGVYANFALWAVSIVPAWLVIRHFGTQEKASSHGSDEDGGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z907</accession>
    <name>A0A7D5Z907_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">vps18</name>
        <name evidence="12" type="ORF">G6M90_00g087560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542360.1">
        <property type="nucleotide sequence ID" value="XM_014686874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z907"/>
    <dbReference type="GeneID" id="26244874"/>
    <dbReference type="KEGG" id="mbrn:26244874"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="627"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="859"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="814"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="966" mass="108706" checksum="FA89859254B2F2BF" modified="2021-02-10" version="1">MSFNPNDGFVATAPTGDASGIDELPIFNVERAQMAFSVTAEFVAAQVANNIMILALSNGRILRIDLKRPEDIDDIDLPKRASEIGVIRRMFLDPTASHLLICTALGENYYLHTQSRQPRPLGQLRGVAIESVAWNPSLPTASTREIILGASDGNIYEAFIETANEFYKREVKHLKNLHKLPDGPITGLWVDDLKGSPDTRRIMIGTQSRLFHLVGKIGRSHDGSGSVYTKLFESEQPVIHEIPRSSSGGHSTVVVSPDSPEGGRADNTPDRAYAWLSSQGVFHGKLLNSPKDSSLGSKVFAESKTLSKAQIIASESTGRHKPTAETVDSLLLTEWHMLSLVGNRVIATNRLTGNTVSEHDVLATGQKAIAFTMDMQERTFWLITSDEIYEIVARDEERNIWQIMMKNKQFDSALQYSRTQTQKETVAAGYGDYLAKKGHWTEAAVLYGRSNKPFEDVALSIIDNNQADALRQFLLTKLANTKKSATLQRTIVASWLVEVFMAKLNSLDDTIITQAELSETMNPAESKMILESVKKEFHDFVNKYKGDLDRKTAYDIISSHGRERELLYFANVVDDYNYVLSYWVQRERWEEVLNVLKRQTDVDVFYRYSTVLMTHVPQETVEILMRQSELKPRSLIPALLEYNRSFSGHANSQNQAVRYLNYVIFQLNSTDAAIHNTLVSIYASHPSKDESGLLSYLQAQGDEPRYDPDFALRLCIQHHRTLSCVHIYTSMGQYLQAVDLALSHNEVELAAVIADRPMSNPQLRKRLWLAVARKVIAKSDGIKAAIEFLKRCDLLKIEDLIPFFPDFVVIDDFKEEICQALEDYSRNIDSLKKEMDESSQTASNIKMDIAALDHRYAIVEPGEKCYVCGLPLLSRQFFVFPCQHSFHSDCMGRKVLEYSGFGHSKKIRQLQMQIHKGLVNGAKREAVVAELDALVASACILCSDFAIKRIDEPFISADDNPNEWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9H5</accession>
    <name>A0A7D5Z9H5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g067420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QLI71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9H5"/>
    <dbReference type="GeneID" id="26246607"/>
    <dbReference type="KEGG" id="mbrn:26246607"/>
    <dbReference type="OrthoDB" id="3219467at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="254" mass="28114" checksum="9606EB6A795E46DA" modified="2021-02-10" version="1">MAVMTASPSAVALGNKMYCFFQGGNDSGELWYAVSNGQYWENKQQVPGTTLSAGPSAVVFDNKIYCFHQGSGDNGELWYNVFDGSLWEGDKQVPGTSLLAGPSAVVFNNKIYCFHQGSRDSGSLWYNVLDGDHWEGEQEVPDTTLSAGPSAVVFGNNLYCFHQGAGDSGQLWYNILSAEGWEGDQQVSGTSLSDQPSAINVIDDILYCFYQGSRKSGQLWYNFWWRNEWRGDRQVPQSSMSDGPSVISFQNNMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9W3</accession>
    <name>A0A7D5Z9W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g077070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545394.1">
        <property type="nucleotide sequence ID" value="XM_014689908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9W3"/>
    <dbReference type="GeneID" id="26241427"/>
    <dbReference type="KEGG" id="mbrn:26241427"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="25447" checksum="391B34E02B76FEA6" modified="2021-02-10" version="1">MPPRLPVCALRAQCSPWSAFRAFSSSPAVASPPREPPHPQPHHQTARPPTPSSSSSLLSISADRHKRAPSVRAMRPGEAAAKMMNRYTDKQNRSRLESVEALRNSKNSADYLKQMPRRWDAGDVYSPHDLSPVEMQKWRKRSLRSNDVVDALGIRPLDMYKNFSLVQEFTTSSGQIIHSAGTSLRPVNQRKIAKMIRRVQGMGIYPTIHDHPEMIRDDFFPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA13</accession>
    <name>A0A7D5ZA13_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">utp15</name>
        <name evidence="9" type="ORF">G6M90_00g075260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545571.1">
        <property type="nucleotide sequence ID" value="XM_014690085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA13"/>
    <dbReference type="GeneID" id="26241604"/>
    <dbReference type="KEGG" id="mbrn:26241604"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="162"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="8">
        <location>
            <begin position="376"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="529" mass="58097" checksum="1DFE00F072F9A94B" modified="2021-02-10" version="1">MAAAQVGPLPKLKLPSGPSPVTAERRYWKTFKNQLLIPSPTSYPVTNISYNSDSFVVTTGTRVQIYSNRTRKLLKTITRFGDVARSGDIRKDGKVLVAGDDTGKMQVFDVNSRAILKTWTEHKQPVWTTKFSPTELTTLVSASDDRTVRLWDLPSNEATATFVGHSDYVRCANFMPGTMSSMVVSGSYDSTVKLWDPRTGSGSAVMTFKHAAPIEDVLPLPSGTSVVAAAGNSVCVLDLVAARPLHMISNHQKTVTSLSLASNGRRLVTGGLEGHVKVFEMTGWNVVNSVKYQSPVLSLQVIPSGDGGDASDRHLAVGMQSGVLSVKTRLTGAEASRERERDREMSALVAGTIASHDAKKSKRKRRIEAANKLDMVGEGADVVIANEPRASRKKERPWQKDLRHARYARALDQVLDRKSPDHTSLNVLTLLLALRHRSAVRDALENRDEQRVEPVLKWVCGHICDPRYVSVCVEVGLHLIDMYAEYVGGSAELHEGFRTLHRRVRSEVQRAQVACQTGGMLESLMMGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCE6</accession>
    <name>A0A7D5ZCE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C6 finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g095230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546807.1">
        <property type="nucleotide sequence ID" value="XM_014691321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCE6"/>
    <dbReference type="GeneID" id="26241230"/>
    <dbReference type="KEGG" id="mbrn:26241230"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45997" checksum="E94D3EB3FC4ED5E9" modified="2021-02-10" version="1">MSFFDAFTRANSFTGRVRTAGDEVKQLADLHSRKGSHLFNAILAVGAMYAGKLNHQRASSKREALSIAFQHYSYSIQGLREAIDGMNLGTSPRLPRHENQRVCILWTTFFLGVFELMNDVTGHGWQQHIIHGTSMALKHSGPTSCRSGPGFAFFIQARIFEVSRSILFNEPTFLTEPEWVSLSRDMWTDEEHLAGSKNTWTSLDSLLDIMVMCSSLRVRAEAFIQGQGSSQDMPPSDSDAMAISQDGHLLREALRSWSAAYIPDAALPSPSTSSTSNKDPENIRHCAADPSTLLARVFYASISIYLSGVFDYELPHWQRRNLPVPALDPATVAQHVCAILALTDTGLNHTALSPVLFLFPLRIAGARSCRQWQRDRVGALLDHIGIAYAVASAIRADLAQVWKARAAIPNPELQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDM7</accession>
    <name>A0A7D5ZDM7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein ABC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">abc1</name>
        <name evidence="7" type="ORF">G6M90_00g096350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546699.1">
        <property type="nucleotide sequence ID" value="XM_014691213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDM7"/>
    <dbReference type="GeneID" id="26241122"/>
    <dbReference type="KEGG" id="mbrn:26241122"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="344"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="693" mass="76439" checksum="0BC00EED2E75FA9F" modified="2021-02-10" version="1">MRFVDLAIDVAALLSASRSVAAKHVALRSRQLDAYAKTSIITAKWRDAKPTASATQSEPEDNSKSEGKRDATSQQTDPLSQSPPRAGNEGHQPRANESRETGTAASGYAEAVKQRQEALRAAAEQKDLPEGVDIDIFHTTRGSSVLSSVRKKNAASRRSQPGGPAKEHPLRHWPSPPPVLPEVEDPVSRETRPGEKTTSHSSATVAEPQSTSDISPEPVHEPSQPETKKLDNETIELAKDLAGVEAPSTPTYALRESKVPATRFSRLWNYGGLAAGMLGGAMTEGVSRAFGGGGQGSVLLSGKNMERMVAKLSRMRGAALKLGQMMSFQDSKMLPGPIQEVLQRVQDRADYMPAWQRDKVLVSNLGENWRDLFSDFEETPIAAASIGQVHKATLESSGEKVAVKIQFPGVADSINSDLDNLGILLNATKLLPKGLYLNKTIDNARLELGWECDYEREAQCALRYRELLRGEEDVFVAPNVHLEACGKQVLTMDFMDGVGVTRVKSFTQEQRDWIGTQIMRLCLREITEFKFMQTDPNWTNFLYNAQHNKLVLLDFGASREYPEAFVREYVQLLDAASRSNRGAIKELSESLGYLTGHESRAMLEAHTQSILTLAEPFMQSAPDVYDFKDQTITERVKALIPVMLRERLAPPPEETYSLHRKLSGAFLLCARLGSRVPCKKMFADSVKRSGYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZE83</accession>
    <name>A0A7D5ZE83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g109010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543950.1">
        <property type="nucleotide sequence ID" value="XM_014688464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZE83"/>
    <dbReference type="GeneID" id="26243337"/>
    <dbReference type="KEGG" id="mbrn:26243337"/>
    <dbReference type="OrthoDB" id="4483229at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="369" mass="40308" checksum="41CB8DB9393C3325" modified="2021-02-10" version="1">MGVTLRSRSSRDVKFPIVCTADIDSQALRDLLSHDVLVLVAKRDLSELISNRDDDKLDSFATPFTADLPDAYDSLGEFMDAAKSRQHGDISHKSFVILDETTAEDGKTCQIAVDGREDEQSNEIQIAFRCELASATHGLAAIEAASENQLKKVIRDLRNEAAMVGGVWSKQRVDEFRSRPNRINVGDYPPHENWDGGSGPENPDTDIPYFPIFQTAEISLETLNQFLKETCDQDWGDEDIAGPSMAFVTSISEAPFHSGKADTHLDSAPKVPSVLFGASAVECDAIVRSRFPGGSEMNYNLFIVLDELTEKEKTVLVAANNELDGQLLLGRTDFQSALTVLVAPSDTSLTVDSQINSAVTEGSGIIYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPW5</accession>
    <name>A0A7D5UPW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g012830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985623.1">
        <property type="nucleotide sequence ID" value="XM_066129737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPW5"/>
    <dbReference type="GeneID" id="26238683"/>
    <dbReference type="KEGG" id="mbrn:26238683"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF27">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="518" mass="56026" checksum="F838D0085B22FD32" modified="2021-02-10" version="1">MDTVESKEVATSHVDDAYVAKQSMVMDGNGRWWNWRVIANLVIVGLAMGLFGYDNAFASPLVSLPLFVERYQGPGFQGALVFSARNLSLIICIPLVGAACGAFAAIPVQKHLGRKGAYILAYSLLCVPSSILQVFAPNLGALVVGRFANYVGVSILTNVCPVYLSELIPAHFRARAVGFTVAGSGVLSVVATVVVWATEKLGDQWQYKIPLLVQAVFPATLALLSLLLTESPVWLLTKGRHDDARRNLLLLRGANAALVEKELALAAAALKSHSEQANVNVWEILKPANLERTISASAPLCLSQVGGQILVLTYSTVILVQSGVADPFKITIIIFLLQFLGTLIGPFLLDKIGRRPVALAGFVVLFAIDVVCGAMACAGLATQSQRIGLAALCIVFSFTNATCFQSIAYVLPTEVPTSRLRESTMAWTTFWSYTTAIITTFAVPQITNADAANLGAKAFLIFGGCMLITLVWSYFYLPETSNRTLAEIDELYAERIPKRHWKGYKSTANEIDNDNADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPY2</accession>
    <name>A0A7D5UPY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS efflux pump atnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atnC_1</name>
        <name evidence="6" type="ORF">G6M90_00g011650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549358.1">
        <property type="nucleotide sequence ID" value="XM_014693872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPY2"/>
    <dbReference type="GeneID" id="26238802"/>
    <dbReference type="KEGG" id="mbrn:26238802"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="458" mass="49172" checksum="E8E91A460CA34CB2" modified="2021-02-10" version="1">MRPTIPVAYLLPFLCVTLFVTQLGLSLSDLPSLKLMQDIACKKHFGLVTQELLPEEKCRDAAVQRILNRINIGISVSVTIGSALVAFPLGILADRVGRVPVLAASLLSLFLSQGYAMLVCWRWEAMPLEAMWAMGVFFLLGGGQRMAEAIVFTMVADVAPRSQRASWFQWVVGAVLAAELAGPFLSARLIESSIWLLLYVSLALVAVGGILLALLSPETLCRKTDGVKEDLDGGSPVTTKRTIFAIFSRPAVFLVPGAVLSLPMAATLSGILFRFMPVQFHWQLSKSALLVSLRSMITLVTLLLLLPGAAYICNKKTTYSHRYRDGIFLRASALCFLAGSAFFVLVLSQGFIIAGVVLSALGSGIPTLCRSMMVSALGEKSTGLLFGILALGEIIGFLCCTVAMGALFDVALTSWIGYPFVLGVVLAGAIFITSWMAGTSKEKATPEKADVVLEPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPZ3</accession>
    <name>A0A7D5UPZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g014760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549047.1">
        <property type="nucleotide sequence ID" value="XM_014693561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPZ3"/>
    <dbReference type="GeneID" id="26238491"/>
    <dbReference type="KEGG" id="mbrn:26238491"/>
    <dbReference type="OrthoDB" id="102260at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028903292" description="TM7S3/TM198-like domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="132"/>
            <end position="335"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="788"/>
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        </location>
    </feature>
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            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1023"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1110"/>
        </location>
    </feature>
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        <location>
            <begin position="1124"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="343"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
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        </location>
    </feature>
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        <location>
            <begin position="79"/>
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        </location>
    </feature>
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        <location>
            <begin position="397"/>
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        </location>
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        <location>
            <begin position="600"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="635"/>
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            <begin position="676"/>
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            <begin position="853"/>
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            <begin position="918"/>
            <end position="928"/>
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        <location>
            <begin position="1023"/>
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        <location>
            <begin position="1041"/>
            <end position="1057"/>
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        <location>
            <begin position="1131"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1177" mass="127121" checksum="50132E71214C28B2" modified="2021-02-10" version="1">MLPKTARLWALLCLALIVQSAVSQSFDVVKRDDNPTPTTIPTSSSSAPKGTNSARIDNDGKDPKERGGESLSSTLSGTITDAPTSTHRPTSTLPLTIATDGPLDNATFFNATIPNGQLPLPPRLTPGWGVAGVIMLVTGVIYTLVGIKNRWIHTFFSTAYMTALGVSVLIVYVMNVPVSNALQGGYVVAVVMSGCAIGAAAMFFKELTEGFGCALGGFCISMWLLCLVPGGLLHAVASKAIFIAVFTVAGFAFYFSRWTRDWALIFMISFGGATITILGIDCFSRAGLKEFWAYVWDINDNLFPLGADTYPVTKGIRVETAAVIIIFLVGIISQIKLWRIVREKREKRAAERAEDQRNLENEEENVGRHIEDLNARERRQWERAYGDGMSHSITDSRATDYGDVGSEKKLRPSYVESKQRTSGEVIEMADMSESDTSRNGMDGLMANEDTDEGKITVRVAADDVPESTTDIEAERLDEKAPSSVEANVLTDGKWYSKETTAGKRRPQAHSMTEVPEVIPLPFTVPEAADSASEGDRSSIATFADDVEATAAEPLKHRSLVKRLSQGSVTLLRSFSHRSGRTGGVGGDVASDAGESTEELVLEKTRRPENEGGSLAATIDDESVSGGNLHSITGDDELRNIHEGDETNRRSIEIDAQLGGKGDTIRYSVKSTKPKTKSSPTSTATSGPVVGISEPNEDTTTELRDTLPTSEDKAMQLGGEPYADLTPPEASERAKSVATASSTPASLTKDRLPRPLSKAAMSYRTNEWAKHLSNAECPEPDALQVTLGRAKKEVKNSTEKAAPVNVAELQKTAKDGTPAPAVRRSISQASDMGNNTHLAKRSSKQDLSPPTRLVTPSSSTGLETSGEQRTPLSPVIAPAALLRKSSGPRHSTSNFMPIAEENSLQAVDSPIVRDEASEKQQPASNNSSAIILDGSPATVLGRNPTSGVVSYSSPQTLIGQREMFLRSKSQGSLLSSTPEPIFAHQGPGSDGGSLFNYPTYAAAFNVADPDDVPLSQRKEIMRQSSLMSLSRSPSQSIKAPSRPTSGFESSESIVFNSHQPRRVSTLPTQAVRESQLASFRQSVQQELRSGTPIITPSGRETPFGPSTLLGGGREAEVQRNIEMQRSVLMGQKEAEAQRRESQKREREHADRAFDERMRNGDMLDAHREAMRKMQKGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ36</accession>
    <name>A0A7D5UQ36_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division control protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CDC3</name>
        <name evidence="6" type="ORF">G6M90_00g007060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549804.1">
        <property type="nucleotide sequence ID" value="XM_014694318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ36"/>
    <dbReference type="GeneID" id="26239248"/>
    <dbReference type="KEGG" id="mbrn:26239248"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="214"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="534"/>
            <end position="590"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="590" mass="66030" checksum="F21E14C603A873AE" modified="2021-02-10" version="1">MATESAKQGKTHTRNSPEAMQDQNGSAECASAEPTIASKRTSSIVAIQHDTTTVLSITTSVTPSIADTVRQYRSMLDVEEPPKLNPLNPMSFDELYTPPSQQPPKSASEKPQYELTANGVCGTLANTADSQVKDLSSSNSSDSPMGSPASPPAGKPESAASAQDAHPSDPAPAVPSQSVPSTIQDARNIVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPRERKGPSLDIIPKTVQIQAISADIEEAGVRLRLTVVDTPGFGDFVNNDESWRPIVDDIERRYDAYLDAENKVNRMNIVDNRIHACVFFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKSDTLTDEEIVSFKARILADIKHHGIQIFEGPRYELDDEETIAENNEIMSKVPFAVVGATNEIKTTDGRAVRGRQYPWGIIEVDNEEHCDFVKLRQMLIRTHMEELKENTNNALYENYRTDKLIAMGVSQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFQQKVAEKESKLKQSEEELYARHREMKEQLERQRAELEDKKQRIESGRPLEKEGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ94</accession>
    <name>A0A7D5UQ94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell wall mannoprotein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MP1_0</name>
        <name evidence="2" type="ORF">G6M90_00g000790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542989.1">
        <property type="nucleotide sequence ID" value="XM_014687503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ94"/>
    <dbReference type="GeneID" id="26244362"/>
    <dbReference type="KEGG" id="mbrn:26244362"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="258" mass="25026" checksum="CA79F4471F2CEB01" modified="2021-02-10" version="1">MKFSNAVVLAAATGTYAQITVIQGVLTSVGGGIDGLNSAASGFNGDVDAVKSKADALVSTIKSGKSKVDSSSDLQLTDALGLTDPVQALTKKGQSLADNFKAKRSDVEKAGACGTVRTELKDINDNSQALIKSVVAKVPKDAQTIAQSLAAGLTKVLDQAQDDFSESNCKDSGSPGGSSSKTGGSSQTSAAAPTTAAATGGHSSASASASAPATTLAPTSAAPSGNGTTGGNPPPVTAGASFLAPAGALVMAVAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQJ3</accession>
    <name>A0A7D5UQJ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g022960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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        </subcellularLocation>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="43594" checksum="18DCA17348CD953D" modified="2021-02-10" version="1">MDYHSIHGHDISSFDIAGTHRLPTVQASQALNELQDDGNLYLSTGLEELDQALLPPTPAASPGSTSVGGIKRGQITEIWGPSGTGKTAVSIQLAANSIHNGNDVVWIDCFQEMDVSRLENVLASIAEDAVPDGSTRAEPPAAGRGKFAQFSCLTLPHFMALVSRPNAKSIPEGTALMVVHNLSALINSSLPRSVDGKTGPKSNKGPTASTKRLQGLQFIINALQKVAATKNCAVVVSSQCATRMQSEHGATLVPAVNASVWEQGISTRIVMFRDWAWKNGALVSIFVAGLQKLDGKSGYDAIERAAAFNVTRTGIARVECDASNAPVEPADVVRGKRKLEQTDLEVPDSQDDEDYGWADDDEAALPAPPPQWQGSEDVLLGQELGRGDDGRDEEEDGCEGSHTPSSEATY</sequence>
</entry>
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    <name>A0A7D5UQM7_9HYPO</name>
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            <fullName evidence="4">Esterase</fullName>
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        <name evidence="4" type="ORF">G6M90_00g019160</name>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
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                <person name="Kortsinoglou A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">4556</strain>
        </source>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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        <name evidence="1" type="ORF">G6M90_00g018650</name>
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    <organism evidence="1 2">
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            <taxon>Eukaryota</taxon>
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36124:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="361" mass="41914" checksum="3F26172D2A77146F" modified="2021-02-10" version="1">MTNEEAQVIVQNICSYEFPYFFDLSQQYALFRTYAVENIAKLLVSVSDLSKSDQSPKRYEDTEIIFVCFAHYAPTSSMLRKAVARMNYLHAPYIKSGRILNKDLLYVLSTAMSEPERFMRLYEWRPLLEMEVAAVASVWKYVGDLMEIDYEAELGKNQWRDAIEFLDDVSQWASKYEEQYMRPMDEVAQLGSVLMDLLLSAYPRALRPLGYQIVMVLMGARMRYAFRFPEPGVAVCALTYTLLLLRKLFLRYLSLPRFCRVVFVTEPDPTSKRMKHLHYLKEPWYTPATFWWRWGPTAWARWAAGGMVPGDNEEMKPEGFLWEDIGPRSTMGKGSEETAKLEEVVQQRATGKCPFAVPSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQR0</accession>
    <name>A0A7D5UQR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inner kinetochore subunit AME1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g026860</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="2">
        <location>
            <begin position="374"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="567" mass="62392" checksum="1D483D71373EBDB3" modified="2021-02-10" version="1">MATGRERREGKLNERLRGAGRTNIDDNDTFNLDIPGIATGPAVQSSSSPGSLPAHPAAQTSLPSRTTSNAPDTRQETESPYQPAGDADLPGPRSSSAPVSAPSERDDPDLDEPEPVQPPSSAVFRGGPRVARTITEEITESPAGKPGSGHRQRINEAVNIGGAPTGRTPDISDEDDAQTQPSSPLANKTRTSNVSRPSIPAVPEESEGEREEEPSDEARTRPPQQRPGIARKEAVVVEEEEEEEEEEEEPEESDHSDEGAVEIDDRRAAQSIGVKRPRPNKTRSPELGSEQSEDSQPEEPVQKRHRRSPAAQRQPAKRPKPQPKQKRHSSGSDRDDDAAIEITVQRFVNNFAQGADDEDELQQEIPFANRGGETVVDVFSQVCEEMISSTLENLQKMLQSSDDLGKKKELRVKIRAIGAYREELNSRLLQHAIHLNHWHSLRRRLRHVQKEKLALRDEIIRLKGEREQVALRMDAVRIKHEADSKESTSRLNASSLMHDIDLAVEQGREAPELSRKAEKEADLGNLDLVLAQISDQVSSTSSTGGLLQQVQDFNAFLERAATALESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQT7</accession>
    <name>A0A7D5UQT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g001910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985739.1">
        <property type="nucleotide sequence ID" value="XM_066129521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQT7"/>
    <dbReference type="GeneID" id="26244262"/>
    <dbReference type="KEGG" id="mbrn:26244262"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336:SF1">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT C_ THIOL SPECIFIC ANTIOXIDANT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="32144" checksum="E6C9DED5B82ED52D" modified="2021-02-10" version="1">MFSSLATKIALKKAGIPSNALDFSSPREPNKLRKDQPADDQESSNWSSWLSYKSLPLTVHPWLSPPPPPIQVSRVPRIGEPAPRDRHDKLATGRGRRVLVVFLRCVGCAFAQKTFINLRTLANRHSQTVTCVAVSHASEPATRKWIDLLGGAWNVQVVIDEDRAIYAAWGLGVANVWHLFNPTTQVQGWKEKGWLGDKVAEAMQRKGTTTAQPARNQQHPERRRAAGAGGAGGGGVGPGEDDNVDDDDGISTVMGNKWQESGAFAIDGRGTVIWGGKAMRADDVMDLEEGAKLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URB3</accession>
    <name>A0A7D5URB3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PR38A</name>
        <name evidence="9" type="ORF">G6M90_00g001160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542954.1">
        <property type="nucleotide sequence ID" value="XM_014687468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URB3"/>
    <dbReference type="GeneID" id="26244327"/>
    <dbReference type="KEGG" id="mbrn:26244327"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="28258" checksum="99DCE1BEF7EBE78C" modified="2021-02-10" version="1">MPQSDTVQADARRFLDERGSTAALAPNGLNPATIMEKAVKDRIVESYFYKEQCFALNEADIVDRVVEHVRFVGGTHGDAQKPSPFLCLAFKLLELGPSEAVVREYLSYGGEHFKYLRALACFYYRLTRRAADVHRALEPFLGDRRKLRTRGRRGAALTYVDEFVDGLLTRERVCATSLWKMPPREVLEDLDELEPRVSPLGDLEDILDEEDEGEGEGEEGPRDEDAEEGEVGGDMDVDREEGGLSRSGSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USA0</accession>
    <name>A0A7D5USA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g007750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549734.2">
        <property type="nucleotide sequence ID" value="XM_014694248.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USA0"/>
    <dbReference type="GeneID" id="26239178"/>
    <dbReference type="KEGG" id="mbrn:26239178"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="386"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="476" mass="52081" checksum="47FC1DF0F2E50A52" modified="2021-02-10" version="1">MAVVGSGPAGFYTAYRVMTKLPDAHVDMYEALPVPFGLVRHGVAPDHPEVKNCQEKFEDVASSPRFRFIGNVSVGLCSRAKEQGMVRLRSLMQHYDAVLLAYGASEDKRLDIPGESTLNGIYSARQFVGWYNGLPECSSLDPALVNAQEAVIIGQGNVALDVARILLEDINVLRNTDITEHALAILSRSRIKRVHVVGRRGPVQAAFTIKEVRELMKLASVAFHPVDRSLIPVDLKSLPRASKRLMEVILKGSEALVESAPKSWSLDNCLAPSRFLGGIQSPEDVAGTEFNVMKLTDAFNPLSKTMATGQTLQLPSDVVFRSVGYKSVALPEFAAMGIQFDESRGVVNNDGLGRATQVLAIDQQTSTCQQVPGVYCAGWVKRGPTGVIASTMQDAFITAEAIVQDWISGAEFLRPKGDTPAQGWNGVRQDEGSHTERSVSWDQWLQIDRAEKQGGKELGKEREKFTNTRDMLAVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USD2</accession>
    <name>A0A7D5USD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase tcpT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tcpT</name>
        <name evidence="5" type="ORF">G6M90_00g000270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543039.1">
        <property type="nucleotide sequence ID" value="XM_014687553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USD2"/>
    <dbReference type="GeneID" id="26244412"/>
    <dbReference type="KEGG" id="mbrn:26244412"/>
    <dbReference type="OrthoDB" id="10260355at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="34148" checksum="5097E96A59CFD212" modified="2021-02-10" version="1">MSASSSIVDALIMGGGPAGLSAALAFARQNQTAVVFDNGQYRNAAADYMHLIPGWDHKPPSDFRAAARSQMTDSYDVIRILEDTNVATAQKTEQGIFQLSDEAGRTWSGKKLILATGVEDVMLDIPGYAELWGKAIFHCLYCKGYEQRGASAGVLAVGPLGNVNTALHIARQETALSKRVTLYCNGNETLAAEIVAGFGTATNMKTDTRKVKEFAAGISGKGIVIRFDDGSEAVEDYLAHQPPTRPRGNLADQLGLEKAPNGEVKVSSPFQQASLRGVFAAGDNGAMLKNVPNAVFSGHVAGQMASTQLLADLNGQKSLFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USH1</accession>
    <name>A0A7D5USH1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547829.2">
        <property type="nucleotide sequence ID" value="XM_014692343.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USH1"/>
    <dbReference type="GeneID" id="26237273"/>
    <dbReference type="KEGG" id="mbrn:26237273"/>
    <dbReference type="OrthoDB" id="4305573at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="59573" checksum="B5C1074B4072F98B" modified="2021-02-10" version="1">MPLQERAIAYFLYHYDLESPSQNKIGDMGFVILSKSDKEWEHYRLAFEACAMASFINETGGQLEYKSLTIETYNKALMAMHSALQDPGVVCEDATLAAVLLLALFECLNPTTGEQESWRNHVQGAIELARGRGRKQIDTRIGQMLFRATRTLMVIYSLATLEDEKEKELWWSGDDECTSTQKLCVGVASLSAKATVLLGPSGHKEEVEVEVMLKRCQAHDRACKARWEELSKSTQGISSDNTDPWLLMLLNMLTCARILLNSIIMRCATWTYKVPNYQTSEEYDGACSALAEIILHSAKVNEQQLCWAEEAQSSFAELDVQLQPGRDSSRCAINKWIEDNRSLWEEKPLVGLQPLAVIWSLECLNDDQKIAIDTQLRRIVGCTVDQIRRSPSYTTEACTRPSPSLSEPATDTPEAGSRDSSPASTGRFRYTQQDDDTLLELSNEGIPWREIRDRFPKRPDSSLKTRLWTLRNCQLTADEDRLLIRLKEEEHCSFRDIAPKMRRHRALVSNRYNQLRRNRAMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTB0</accession>
    <name>A0A7D5UTB0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g025450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548038.1">
        <property type="nucleotide sequence ID" value="XM_014692552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTB0"/>
    <dbReference type="GeneID" id="26237482"/>
    <dbReference type="KEGG" id="mbrn:26237482"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="207" mass="22331" checksum="9F420445F63A6DA0" modified="2021-02-10" version="1">MTLKRKRSEPELCSSPSSCSSIFSSPPSNSAIDVNPQAFYNMPPAHLNSRTMKRFRNNRPSEEIVHQHTLNLLFSAQQQQSQTVRETGFQPLPQTGSASEPRKQQSLHRFWSINSAPSPVSESTVEQPALAPTSCEDCGAGLGPGGNAHEMAVDDLTADNTTCGACGKHVCFSCSVSNLGEEKRCLCCAGRKAFGNIGWPNMGLSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTV3</accession>
    <name>A0A7D5UTV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase OMS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">OMS1</name>
        <name evidence="3" type="ORF">G6M90_00g039300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547284.1">
        <property type="nucleotide sequence ID" value="XM_014691798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTV3"/>
    <dbReference type="GeneID" id="26239847"/>
    <dbReference type="KEGG" id="mbrn:26239847"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="382" mass="41186" checksum="9574F476874A4A5C" modified="2021-02-10" version="1">MVTTRGFARATRLPRRFASTASKAARKQPPAPAPSPPPPPPPRLSKSYKPSPRSAPSQPRRAPNPSRPGDTLQSLWRRSWLPLSGAALLSGFLGFYIIGTAAASLKTRPCQASCEHAAPTGRPPALTGDNAEQFDKELDLPERWMGITKLRKKLAGHAKGHVLELAVGTGRNLQHYNWDALGGTHPAPGKQTAAGGISSFTGLDISADMLDVARKRLVAAVPPVADSEPSAGRSALADHMGGRLSLLDDRLRLICSDAHRPLPRAAGAGATYDTIIQTFGLCSVSDPVAVLCNLASAVKPDTGRIILLEHGKGWYGLVNGLLDKNAEKHFEKYGCWWNRDIEALVDEAVQKTPGLEIVKLDRPNIMQMGTLVWVELRMRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTX7</accession>
    <name>A0A7D5UTX7_9HYPO</name>
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        <recommendedName>
            <fullName evidence="3">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g038200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547178.1">
        <property type="nucleotide sequence ID" value="XM_014691692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTX7"/>
    <dbReference type="GeneID" id="26239741"/>
    <dbReference type="KEGG" id="mbrn:26239741"/>
    <dbReference type="OrthoDB" id="1858978at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF110">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028834320" description="Neprosin PEP catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="3">
        <location>
            <begin position="117"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="385" mass="41229" checksum="5650BF664BA9D45F" modified="2021-02-10" version="1">MKTSILPALALIGLAAPGPLPPAPPGHGLPIVKTTTTPGGQTLDWVPISSQGDIAQPPPPSLLKRAPTRQDAAVVAAIRPSDAGPAGTVPILRSHGPTRPMKRLPRPGDNAAAAAVSARSQQGTHWYASTAQNASNHGGTATYSIFKAFVQRPSDFSLLQVAVIRNDAAHAGTPPKSQTVEAGWINYPDQVAAPHLFSFYTTNNYESYGDGVCGWNRDVAGWVQYDGEIYPGVAFAPLATVGGDRYEADIGFYYHQGNWWLHTLGRFVGYYPGSLFSKGVDPADTLDHHSDQINFYGEIYNSEDEMTTTDMGSGEFPDKGFGYAAYLRKIAYYDTKDTFQNYNGSRGVVISDQSRYNLSAVWNSGLDWGSYFFIGGPGAGGVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUQ9</accession>
    <name>A0A7D5UUQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SDS23</name>
        <name evidence="13" type="ORF">G6M90_00g042210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547559.1">
        <property type="nucleotide sequence ID" value="XM_014692073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUQ9"/>
    <dbReference type="GeneID" id="26240122"/>
    <dbReference type="KEGG" id="mbrn:26240122"/>
    <dbReference type="OrthoDB" id="4938668at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="279"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="498" mass="53327" checksum="CA92DF754AA00E76" modified="2021-02-10" version="1">MDPSSGSVRGRGEASGDSGSPRLASVDPSHAGGSNHEGPPQRTPSLSNMNKSAHRQSFAENLRNVPPSPRHRHPSFTQAAVQELLNHPPSGQRHTNPKFAGKEWVEITVGELVSPDDVKWVDMDSSVEEATMALLKSKTNVVLVRESSSLPAAVATFDYSDLNAYLLVVVGLSKPETHQVELYNDIMLNAREGKNISMRQIQPLCRQEPLVGLPSNGNLAQAIEILGSGIHRILITNSLGNVVGIMSQLLMVDFFWNEGVNFPAVDRLYPIMLRDLGVGTQQVISVNSDAPLAEALILMNNEGLTSVAVVDNGQNVVGNISTKDVRHLTSASSAPLLDGSCMHFISVILNERGVEKGRDTFPVFFVNTYSTLAHTVAKLVATRSHRMWVVESASPSPSAPATPLMGPHGVVSTPQAPMATPTSAVPSGAVPASAMPGAHLSGKLSGVLSLTDVLNIFAKYTGLHPADPSEQRARRRRSSSSSIRPSLDSSRPSLDFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUZ4</accession>
    <name>A0A7D5UUZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3716 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g041380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547484.2">
        <property type="nucleotide sequence ID" value="XM_014691998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUZ4"/>
    <dbReference type="GeneID" id="26240047"/>
    <dbReference type="KEGG" id="mbrn:26240047"/>
    <dbReference type="OrthoDB" id="4800057at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="895" mass="102804" checksum="C5224E3DE767220C" modified="2021-02-10" version="1">MEVVDLLPAEEQRSVWDETERNFWLKFDHENDANYGKSEQRYKMREAETRANLDKLTVKRTQLTEKQDRLLKELTQVEEELARVVEECDDKATKLNILEQKYRQSEHDRLEQRNKIAKSMERFFRVKRGEDPDAPSERDKEQWHEVLRNSTRSGDEGREAARAEALEQANEAARSTQALTPVKSALVPPVTRRSSNVLVDIIDADGHVIGPIERTDPWNQWVEAIQDLPIKQQVRIRRGRKFTSDHLATIYDRSEAKGVKWLACMIQATGEIQPRRCHSCDKNQGAFEDCVVLGGPLFQKCGNCEWNRQGCHMPAPYKSANRGPRHEQMQYHDVGKEPEQLAFRMPPANQSRQTLRPYLSREAGIARSSSRLNGSPVLPEPIQMPTPKESREHPFSSLKSHQALSGFTPANYRGRPPSRDIPTPSVQSVENSPQPTRQHLPSSDEITRSNLILKHNGTVYTFPECVEGVPLVKIDEDHPYWDPRWPPVREIIQPQLDLWQEKYDESVERKAKGEGGSSKFQNGRQVNRGRKILEFLEDGDISPYQLLSKQYTHTGKGTITAYDTLFRMCETLGELAKYRLDISPVDWLRHRLHELIVEKGANFNYSKIMHDFYHDPKLAALRSKNGFKSIGRPSGYRAGQIGGNDNNSTPQGGMKKRKSMHSQTDTPRQTPSSSHSPSLAQDDYSHSPLASNAAPYSTNSSFNAPPIQKRLKPLSPVSTHPNDEFYTDGISDTDSWSGAPIQTLDWRIYQVKTRLFTSSTEVTQYWHWKEGRRLFEHQVLKDTDPISWGILRSPIDFDIPLDDITRVDWNIDALQVHFVMSQFSSRIAKQDGKPTGDVMAAFKRETTMRRFLNYCRQRRLKLVKVTADEIEQRWGNMQSEKLPDTDEEASPAFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV10</accession>
    <name>A0A7D5UV10_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g032150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986304.1">
        <property type="nucleotide sequence ID" value="XM_066130101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV10"/>
    <dbReference type="GeneID" id="26243951"/>
    <dbReference type="KEGG" id="mbrn:26243951"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF42">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="314" mass="34797" checksum="50A6597789A68DCB" modified="2021-02-10" version="1">MALQIEGQDPNICSDLIAHFAPDTIDSELVVIQYSWLPKTQSDFPAIRACIFDMDGLLINSEDIITLSTNQLLGKYGRPGFTRSIRAQLMGVPDSTNGDVFHDWAKLPISREQFARELTEQFRLQFPNCRPLPGAEKLVTNLSRARNVSSGNGVELALASSTKSHSYDLKTRAPETRRLLGFFQSDKRVLGDDARVRQGRGKPAPDIYLVALQSLNSAVGDGEKAIMPNECLVFEDSIAGVEAGRRAGMRVVWVPHPDVAVEYQERQKSVLAGRTGMFGVGDDWQLGDIDDGWAESIPSLEHFNYDKYGFHVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVG4</accession>
    <name>A0A7D5UVG4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mts2</name>
        <name evidence="13" type="ORF">G6M90_00g045220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986458.1">
        <property type="nucleotide sequence ID" value="XM_066130365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVG4"/>
    <dbReference type="GeneID" id="26242023"/>
    <dbReference type="KEGG" id="mbrn:26242023"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="235"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI67835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="457" mass="50596" checksum="BCAEB04564CB8C70" modified="2021-02-10" version="1">MGQGQSGMGGGDGREDKDKKKDKPKYEPPPRPTTRVGRKKRKAGGTSAAAKLPAIYPTSRCKLRLLRMQRIHDHLLLEEEYVENQERLRKAKAAKEGAAVGPDADVDRLADERGRVDDMRGSPMGVGTLEELIDDDHAIVSSTTGPEYYVSIMSFVDKDLLEPGASVLLHHKSVSIVGVLTDDTDPIVSVMKLDKAPTESYADIGGLESQIQEVRESVELPLLHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLVRQLFQVAGENAPSIVFIDEIDAIGTKRYDSTSGGEREVQRTMLELLNQLDGFDDRGDVKVIMATNKIDTLDPALIRPGRIDRKILFENPDQNTKRKIFTLHTSKMNLNDDVDLEEFISQKDDLSGADIKAICSEAGMMALRERRMRVQMADFRSARERVLRTKQEGEPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVL6</accession>
    <name>A0A7D5UVL6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dbp6</name>
        <name evidence="10" type="ORF">G6M90_00g033690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543296.1">
        <property type="nucleotide sequence ID" value="XM_014687810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVL6"/>
    <dbReference type="GeneID" id="26244097"/>
    <dbReference type="KEGG" id="mbrn:26244097"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="335"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="680"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="630"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="650"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="854" mass="94103" checksum="1524EE50673C0DFB" modified="2021-02-10" version="1">MYARYVPPSKGAKATAPAEPSAPKSSPAPKPDAIESRLVEEFSYTRYVPGAKAAAKSSAPSVSAPKSIQYFNDEADSTPKRKREPATEEQQGSESKKIKRVKDATAPRDDTAAADSQPGAKKKNRRKRKQRTQANDSSDDSDDEPKHTTAMSSVKIQDNVEEAPPVDIVENGADSRDRESDVEMAEGALEAEEQTKEKKKKREKKKKQAKGVTEEQDKDDENDMARHKAVLERKTKSIKLATKIAQTKHDESDEESVESHGLEPLPQPAPVPEDESKPTYDTLPPWLSNPIRVAQDTKAPFTDLGILPRPSRILAEKGYNEAFAVQTAAIPLLTPTSKRRPGDLLVSAATGSGKTLAYALPIVRDISNGVVTRLRALVVLPTRELVKQAQDVFEVCAKAYEGEDRKRVRIGVAVGSQSIKSEQEAFIERESRYDPEAYSKIQEEQRQQRAITFSADVDDTHDLDSANIDARLGPWKGEVVDFSSKVDVLICTPGRLVEHIEQTPGFSLDYIRWLVVDEADKLLAQSFQGWLDLVLEKFQVNKFSARDFPDMAYSGVRKVILSATLTRDLSLLNQLALRRPRLVVLENDGAVQVAEHALPVGLREFAVRVHEANLKPLYLLDLLRQSHMTGPVGNGDSSSTLKEDEDTSDSSDTSSDSDSSGSDSDTTSESDTSDDESTPPAPKTQIPISLIFTKSNESALRLSRLLTLLDASLTSQISTLTSTTPTHIRRKVLRAFTTPSSPVRLIIASDLVARGIDIPKLGHVINYDLPASVAGYVHRVGRTARAGRSGCAWTLIGDDESGWFWGKIAKNQAIRRTQKVERTRIEEMTEERVQGYEAALAILGKEALELRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVN2</accession>
    <name>A0A7D5UVN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g043870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547722.1">
        <property type="nucleotide sequence ID" value="XM_014692236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVN2"/>
    <dbReference type="GeneID" id="26240285"/>
    <dbReference type="KEGG" id="mbrn:26240285"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF95">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028928336" description="alpha-glucosidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="9">
        <location>
            <begin position="128"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="282"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="10">
        <location>
            <begin position="730"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="926" mass="105660" checksum="B575758FAB468ADB" modified="2021-02-10" version="1">MRAGAVIQFFFALGGIAATPKPNTRDRLRECPGYRAVKDGQISDGLWRFLEIHDDRARFIDLELAGKPCNVYGKDLPFLKVTHVVETPTRLHVQIADPKQEAYQIPELVFPRPKFSKKRQSKKPLLEFEYTEYPFSFRIVRTKDTTILFDSSAAGLVFEDQYIRLRTSLPVNPNLYGFGEHSDSFRLKTNNYTRTLWNADTPSVPAGWNLYGSHPMYIEHRQKGTHGVFLLNSNGMDVVIDSDPYSAYLEYNILGGVLDFYFFAGETPIDVAKQYSEVVQQPALVPYGALGLHQCRWGYQDVFNVAEVVHNYSQAGIPLETMWTDIDYMDGRAAFSLDPERFPLQKMRQLVQHLHSRNQKFVMMLDPAIAVKDYGPYNNGKTWPMSFLVNSSGLPYEGVVWPGRTVYPDWFAPAIQEYWNKEFDTFFNPATGVDIDYLWIDMNEPSNFCDFPCNNIDEVALLYPPPPPLVRSPPRELPGWPCDFQPPGTKCDDNGIKPLASPKKPRAVYLYFPEPMLSIPPLYFPLMEEVKPGYRPFFLGFDNRDLINPPYTINNAWGMLPQKSLNTSIRHSNGLTLFDTHNLYGHMMAAASRRALIAMRSHKRPFIVTRSTFAGSGAHAAHWLGDNDSSWEHYRLSIRQMLQFNSMFQVSMVGSDVCGFNGDTTEELCARWAMLGAFQPFYRNHNAEGQIDQEFYRWPSVTQAAKKAIDIRYRLLDYFYTALMTQSSDGTPAINPMFYIYPKDANTWGLDMQYFFGPSLMVAPVQEQGSTSVKIYFPNDVFYDFHTHEQFFGIGQYATRTNQTITDIPLFVRGGQIIPMRARSTMTTTELRQQDFELLIAVGSNGRAKGVLYLDDGETLQKPPHSYIEFNYKGGRVTSKIRSMDFKTGAKITKITIMGGKRCGPGKSSCSKDLHHPLKKRLSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVT6</accession>
    <name>A0A7D5UVT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yip1</name>
        <name evidence="9" type="ORF">G6M90_00g039960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547346.1">
        <property type="nucleotide sequence ID" value="XM_014691860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVT6"/>
    <dbReference type="GeneID" id="26239909"/>
    <dbReference type="KEGG" id="mbrn:26239909"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="123"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="316" mass="32940" checksum="67D098899613FC1F" modified="2021-02-10" version="1">MSNYYGGQPNNPQYGAPGAGGGAQNLQFYPSSYSPAVSGAATPQQASYGYGAGASGSFESGAQAGFSSAGFGGPGVSGRMGEHGGLRTGWLAAFSTEGYDGEPPLLEELGVNFGHIQMKTLAVLNPFRHIDQHIMDDSDLAGPILFFLLFGTILLLSGKVHFGYIYGLALLGSTSLHMILSLMSPTEPPSSESYHPQYNDPSSPPQHQQGGHFSATLTFPRSASVLGYCLLPLVVTSLFGIVMPMDTPLGIVLSTAAIMWCTYSASGMFCAVGRMKGMRGLVAYPLALFYVGFGIMGIFSSRGSGSLANAAAKINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW41</accession>
    <name>A0A7D5UW41_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RRD1</name>
        <name evidence="12" type="ORF">G6M90_00g036150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547008.1">
        <property type="nucleotide sequence ID" value="XM_014691522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW41"/>
    <dbReference type="GeneID" id="26239571"/>
    <dbReference type="KEGG" id="mbrn:26239571"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="459" mass="49612" checksum="308DC4DA5E5C19A3" modified="2021-02-10" version="1">MATPPVAHLNPTLQVIPTAQLASHKFIKPTKRINEGHHVAHFLTSKAYRDICAFILQLNHSLCPRNQTSSPIPKTFPLVPGSPSSTPSIQAVQQLLSEVEALVEQAPPDPGPRRFGNVSFRKWHALVEENLDSFLDKGILGQALSAKGADGVTAKDEATAYLMGAFGSAQRLDYGTGHELSFVAFVGCLWKLGFFSDGKDDGDIEREIVLDVIEPYLRVIRTLILKYTLEPAGSHGVWGLDDHSFIPYIFGSAQFTRPITFVTEPMPLEGSVKGAPKPGDVTKAAVVEDLRQTNMYFSAVGFINDVKKGPFWEHSPILFDISGIRDGWGKINKGMIKMFNAEVLSKFPVVQHFPFGSLFSWDADPSAPVPAQSVHMMNQPVAVAASTTETPPLSATGTAAPWAQATRMPPPPGPGIPYSRVPTGPSTGSFASRQPRGEGPGSRSAAAQITVTKAPWARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWE1</accession>
    <name>A0A7D5UWE1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PMT2</name>
        <name evidence="17" type="ORF">G6M90_00g034640</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986617.1">
        <property type="nucleotide sequence ID" value="XM_066130154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWE1"/>
    <dbReference type="GeneID" id="26239424"/>
    <dbReference type="KEGG" id="mbrn:26239424"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="670"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="402"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="466"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI68595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="742" mass="84480" checksum="65AA6964C83CDC39" modified="2021-02-10" version="1">MAGEKAAVASGADVGEGLRKRPVNNGTPAPVAPQPTDNKKQAAQKAEKNLIDTFVEWEHIIAPLIFTALAFFTRLWKIGLSDIVTWDEAHFGKFGSYYIKHEYYFDVHPPLGKMLVGLSGVLGGYNGSFEFKSGDKYPEDVNYTFMRAFNALFGIVCIPMAYYTARELNLRRPAVWLVTLMVLCENSYTTISRFILLDSMLLCGTVATTLCWAKFHNQRHNSFEPEWFFWLFMTGFSIGCVCSVKLVGLFVTALVGLYTIEDLWNKFGNTKMPITTLTAHVGTRVVGLIVVPFLIYLLSFALHFAILDRTGPGDAQMSSLFQANLKGTEVGKNSPLEIAYGSRATIKNMGYGGGLLHSHVQTYPEGSQQQQVTCYHHKDANNDWFFYPNRREPDYDAESPDLRFIGDGTIIRLIHAQTGRNLHSHDIAAPMSKSDKEVSSYGNLTVGDEKDHWKVEVVRDVASRDRSRIRTLTTAFRLKHEVLGCYLKGTNKNLPQWGFKQIEVSCTKENNPRDAYTHWNVEAHWNDKLPAGDPGVYKSPFFHDFIHLNVAMMTSNNALVPDPDKQDDLASKWWQWPILHVGLRMCGWDDNIVKYFLLGNPLVYWGSTIGIGIVGLVVVWYILRWQRGFADLNNKEIDQIHYSGIYPVAGWFLHYLPFVIMARVTYVHHYYPALYFAILTFGFLVDWTVRNRNTIIQGTTYGVLYAVIIGLYVLFMPVCWGMVGPNQQYSYMRWFDNWRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWT5</accession>
    <name>A0A7D5UWT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g030220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539735.1">
        <property type="nucleotide sequence ID" value="XM_014684249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWT5"/>
    <dbReference type="GeneID" id="26247492"/>
    <dbReference type="KEGG" id="mbrn:26247492"/>
    <dbReference type="OrthoDB" id="4935043at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="57"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="232" mass="25674" checksum="0434D4C9E8076F95" modified="2021-02-10" version="1">MSQSTPSPSAAAMDDASGGSRAFVIIVTIGSITTISLRFWSRSIQRAPDGLGGSHVSRFWWDDWAALAAMPFILGLCGIIFAMLYHGLGRHIQFVPPDKVAIFLRLLYALYYMYNFGLFFTKCSALLFLSRIFSWHANTRCFNYAIATTHLLNAAWLLGVTFGTVFMCNPVEKGWSQPLSCGPTSALWISSAVPSACIDFIILVLPLPKIWALKMTRARKVGVTGIFVLGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWU4</accession>
    <name>A0A7D5UWU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g055700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544164.1">
        <property type="nucleotide sequence ID" value="XM_014688678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWU4"/>
    <dbReference type="GeneID" id="26242576"/>
    <dbReference type="KEGG" id="mbrn:26242576"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="41602" checksum="575CDA1ACA70499A" modified="2021-02-10" version="1">MAESENHGNWLVCAMTIVWVWSTLIFFVRVWAKVTAKRWGAEDYTISVAFLVSTMDIVPIMSAIHRGYGLPMDLIPPEDQLVVTQSLYASQQLYIFALGLSKISTALFVIHLAYSGPQIRPGYVLVGVTAIWTVGSMLVVALRGHRRHPWQTLDGTTTMYIRWIVVEATGLIIEFLLILLSLSLVSSLQLKAQKRLVILSAFAARLLLIPLVAARLWLLSPGVNSNPTDTSIVPSIITQATLHFSVLSASITSLRPFLRTFHMDYKWDSKVTSKRNYSSTGYTTTGPSAKNVYGTSSQSGQADRHWADDFTDPSGTDAHFLNRPSTGGTARNNDGIIAWAHVDEIQMRPPFPAKAMVIRKTVDWTVEYEPNTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXG0</accession>
    <name>A0A7D5UXG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein LONG AFTER FAR-RED 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LAF3_1</name>
        <name evidence="2" type="ORF">G6M90_00g056270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="26242632"/>
    <dbReference type="KEGG" id="mbrn:26242632"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF20">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="63"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="552" mass="60110" checksum="0D900D1B86FD7762" modified="2021-02-10" version="1">MGDLGTDQDLTVFVNGNIYQSPTNNVDNPSFASGMVVQNGTIQHIGSEHDDAVSTAKQSGANIQDLGGQTILPGFIDGHLHLLLVGQSLTKVSLDACKNLEDIRTEIKKYAQSHQDVSRIFCRGWMHSMTPEGVDATLLDDLDPRPIFVDTKDLHSTWCNSLGLKEICKVMDINDDTPDPAGGSIQRDKDGKPNGVFNEGAVFQTIWPFVARVASMEEKKDAIQSAFKAFNAVGYTGMIDMAMDDTIWEPLVALRNDTNGLQGMRVAAYWLMKPTDSLDSVLAQVDRAAELARLYNAETTPDCRIVGVKVITDGIIDACTASLTEPYCNGENPDSLWPEDLLHHLVARAHAAGLQVALHAIGDRTIQMAIDVLEKNTDKSRRPRIEHLELASARDAARLGKLGITASIQPVHSDPAILRAWPRLIGDDRCKRAFAYREFADGGAPLALGSDAPTAPHEPLPNLYVATTRRSYREPGFDTAVNPHFALTMCQAVAGATHGSAYSSFADQWTGSLKAGLKADFVVCDVDLKPENVVKGVVRETWFEGKQVYKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXP2</accession>
    <name>A0A7D5UXP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g057910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544371.1">
        <property type="nucleotide sequence ID" value="XM_014688885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXP2"/>
    <dbReference type="GeneID" id="26242783"/>
    <dbReference type="KEGG" id="mbrn:26242783"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="91921" checksum="263105EE5137E9CA" modified="2021-02-10" version="1">MARLRPTLPDGRLGNQQSVVDPSRLQIRVVPYSPPRISSDGSTPSRPVSYVEVSPKRPPLASCQDRENQPKNDTGGSLCLLEVESQLQDSTGPDPLMDLTNETAESADHVNKVENWSIVSPTTIPAPPSPSYRPPRRTIAVNSDKTFSLLPQSCSSASAVEGLRSPRRSSTAPSSSADRTISGTFGDDQPSSPLTPPQELSRSPCSPCSSPFPASFIAASSPSNYTLVGGVRKVPDNDGGGKAKALSIPSLPVERDLQAAFVGSRPSASGYTQPGMLSSKQSFPSESASTLSERSNYKTFVSESHYSGPDRHFEAADDSNAKLSLLSSSHSNFEIIGETCSEQSAENRSSSDTNDSNRNYVLHGDFPSSPPTAVASGCVLKTEYSRESLVVAPLRPSKRFFSDQATVSHQKSRDSIRTGSLTSISSVFVEEAARSLFAGGSVITSHGGGIRHTSPRRNTTIGPGNRHQNLSYHHHWSATLSPILSESDRGSAVPSLAFSHTTAGDRRLQSQSFDVGTPDLPRNDGQPNVEAWMELPPPASYRVWNRDFNNSSLRLIRDQDEHGDGLAELEELHRRPSRTRLHSYLSSLPSDRNLRSSGSSRSNSFSRCHIPAWARLYYGSGERRFLTIQHSSESLFSEFSASVHNSPLISRSPSVKRFTPGTQLPPQHRPPPAPCEAPSAPQSASDGPVPCPPLNMVCRIKKQTSSIWSPHLRRDRRSRRYNLWRPPSTVWIKEEHISRRSNIQAILFVSGFVFPFAWMIASFLPLPPTVEADMKEKNHSTSHVDLEQGRSGSNLEQDSDNCYNKVKWWRSLNRYMSIIGLLLVGAAIALIVTSTQQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYA6</accession>
    <name>A0A7D5UYA6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SSB1</name>
        <name evidence="10" type="ORF">G6M90_00g058620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544437.1">
        <property type="nucleotide sequence ID" value="XM_014688951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYA6"/>
    <dbReference type="GeneID" id="26242849"/>
    <dbReference type="KEGG" id="mbrn:26242849"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="614" mass="66546" checksum="B48AB7BC06DA4E89" modified="2021-02-10" version="1">MGDEVYDGAIGIDLGTTYSCVATYEGTNVEIIANEQGSFTTPSFVSFTDKERLIGDAAKNNAAMNPQNTVFDAKRLIGRRFDDPTVKKDIESWPFTIIDDAGQPKIQVEYLGEKKEFSAQEISAMVLTKMKEIAETKLGKKVEKAVITVPAYFNDNQRQATKDAGAISGLNVLRIINEPTAAAIAYGLGSGKSEKERNVLIYDLGGGTFDVSLLNIQGGVFTVKATAGDTHLGGQDFDTNLLDHCRTAFTRKTKKDLGGDARALRRLRTACERAKRTLSSGAQATIEIDSLFDGEDFTMTITRARFEELNAKAFSGTLEPVAQVLKDAAIEKSAVDEIVLVGGSTRIPKIQKLLSEFFDGKKLEKSINPDEAVAYGAAVQAGILSGKATSAETSDLLLLDVVPLSLGVAMEGNIFAAVVQRGNTVPCLKKRTFTTVADNQQTVQFPVYQGERVNCEDNTSLGEFTLAPIPPMRAGEAVLECVFEVDVNGILKVTATEKTSGRSANITIANSVGKLSTGEIEKMISDAEAFKSNDEAFSKRFEAKQQLESYIGRVEEIVTDPTLSLKLKRGQKEKIEQTISEAMATLEITESSAEDLKKQELALKRLVTKAMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYG7</accession>
    <name>A0A7D5UYG7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PRISS</name>
        <name evidence="5" type="ORF">G6M90_00g052230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986789.1">
        <property type="nucleotide sequence ID" value="XM_066130531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYG7"/>
    <dbReference type="GeneID" id="90967771"/>
    <dbReference type="KEGG" id="mbrn:90967771"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30962" checksum="571062D72D90657E" modified="2021-02-10" version="1">MFLVWIFVWDDDLDLPYSEVASTKGQAIAYCRESVESARKSLSLTRSGGVNDVKVRAPFPIMGLFDEFASTLLGATDQAQRQRVFAEIEVYISEVAGEHARQYDKILPNVDEYLQMRMGTSGIMVFLAFSDCINGIRLPEWVMQSDEMTTLKIETTRLAMFVNDIYSLKKEIISQTPQNIVPILLHRSKGKTLDETMLQLSIMFRTAAQQFENGFDNLVVKVKDDHVVDKDMHVYADSCRTLVTGLIEWSKKTARYNLSQYEDEGGVFKIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYH2</accession>
    <name>A0A7D5UYH2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pzh1</name>
        <name evidence="11" type="ORF">G6M90_00g059380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544509.1">
        <property type="nucleotide sequence ID" value="XM_014689023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYH2"/>
    <dbReference type="GeneID" id="26242921"/>
    <dbReference type="KEGG" id="mbrn:26242921"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="329"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="539" mass="58793" checksum="2183354F1FED3F5F" modified="2021-02-10" version="1">MGNQASKEGNGSSTGKGSGSDGPLQSYPSMSRSDTKESSRSFRSLRSKIPGSSSSKSVNNTDSPRNSALLPNGESNSEKALDAASVRSGRSGRSSASRNSRGDLPSLKHNSTDLSSADPAIFEHQPPPSPVLSSAKGAAHDVAAAQASGEVDHVSDQPPTASNASATAHMLSPGQPILVKRDSTVNNIQNSPSMDSTTKVESNGNMAMSEIKDMDLDDYIKRLLDAGYAGKVTKSACLKNAEIVAICQRAREVFLSQPALLELDAPVKIVGDVHGQYTDLIRMFEMCGFPPMANYLFLGDYVDRGKMSLETILLLLCYKLKFPENFFLLRGNHECANVTRVYGFYDECKRRCNVKIWKTFIDCFNTLPIAAIVAGKIFCVHGGLSPALSHMDDIRNIARPTDVPDYGLLNDLLWSDPADMEQDWEANERGVSYCFGKRVITEFLAVHDFDLICRAHMVVEDGYEFFNDRVLVTVFSAPNYCGEFDNWGAVMSVSSELLCSFELLKPLDSSALKSHIKKGRNKRQQMLNSPPASVQPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYX1</accession>
    <name>A0A7D5UYX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">NOP7</name>
        <name evidence="7" type="ORF">G6M90_00g059810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
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            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <sequence length="875" mass="90900" checksum="C3D210815318DEBF" modified="2021-02-10" version="1">MKYLVTALSAATLATSVAAQVATLDPAEDIIPIIPPDVLTNVQEERKYDACHKIDTSVAGGLIWPCASQLKILESCPKSAKTAEERKAQRDCICGKGSSFLQDAVACSECKIQNGLQPDNQRDFWKKSFGALDKEYCQSDDVAVDYKEFTKDWTPPKGVIAGNSLDGQIGNPRDYYKQAGVAVPEKQGPGKSTPAALHPGVNDNTVNADISDPLAGQVVVPAYVAVEVNNKPSGANTAPVTTTPSAAGSQPTTLVRVTSGDSTAAATASLSPSSSLVPASGSNGGADVAHIIMINGKACHVYIIWVIIDCAPKKDAQGNLYIEYKNNGIDNNKPVSMLENKKQFDQIKDTVHDASKDDNSAKELKDIVGTEADVVAAPGNKKPLPPPEKPASGEPQAPNGAAGSGTSDEPVTGTTVNTPDVSDDKDECVNEDLTGGANTPDNGSTNTESIPSGSTGTGAPNSKPAADINTPAMSDDDECDNEDLTNGANTPDNGSTNTHNPENILSGGTGTGAPNKKPATDNNTPAISDDEDECVNEDLTNGANTPDNGSTNTPNTENVPSGSTGTGAPNNKPAADNSTPAVSNDEDEFVNVPSGATTPDNGPTNVPNTQNTQNPPSGGAETIVSSLEDTMKNPNTPQGPKKTPSTQNPPSGGAETVVSSPEGTMKNPNTQHTENPPSGGAETVVSSLEGTMNTPNTPQGTEKTPSTQNAPSGSADTVAPGPNGTKTTPNAPAQNSAGTPGGQTGSNTPSNSGSQSETKDCECASGSKAPERKDADEICAKREKTETDCNKESGENMRKCFCSEGSFQNQRFFEEAITCSRRSDNCRLGEYGAQVFFQIQHLYCDLKLFGNDYAAAYKNVLDSWGRERAPTASLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V054</accession>
    <name>A0A7D5V054_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trichothecene biosynthesis protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRI14_2</name>
        <name evidence="2" type="ORF">G6M90_00g078000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545305.1">
        <property type="nucleotide sequence ID" value="XM_014689819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V054"/>
    <dbReference type="GeneID" id="26241338"/>
    <dbReference type="KEGG" id="mbrn:26241338"/>
    <dbReference type="OrthoDB" id="4434395at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd12811">
        <property type="entry name" value="MALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054550">
        <property type="entry name" value="Mala_s_1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22701">
        <property type="entry name" value="Mala_s_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028971106" evidence="1">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="338" mass="36550" checksum="3BA0750DBB008F64" modified="2021-02-10" version="1">MLFALVPLFAAGVAQAGPVQSKEIVINSYQLYPENIDYDTKTRLAYISVLYNSTVAVYNPFTNKVTKTIAFDKLSYDPVLHASGVQVDPLGRLSVIVNAGAAFDTRGANISGDNFLVKYDLARGQELWRANLTAVTDGIYSGYQDIEHDACGNSFAVGTWPSSIVRVSKDGKTAAPWYLTNDKDHTKKGLTGLASKGDILLATEHTGSRLLRFDMKADKGVPDVVPVGQDGIGERPDGIYLPSKFEGKVLLVSSQLEGTVVLRSDDGKWTSAQRLGVVPNKFADEGGSTTASVEIEGRIFVSTEWFGDAANKVPDTLSGNRTEFPLYDITSEVVKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0B4</accession>
    <name>A0A7D5V0B4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endo-chitosanase</fullName>
            <ecNumber evidence="10">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">csn_1</name>
        <name evidence="11" type="ORF">G6M90_00g074100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="10"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987026.1">
        <property type="nucleotide sequence ID" value="XM_066130994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0B4"/>
    <dbReference type="GeneID" id="26241689"/>
    <dbReference type="KEGG" id="mbrn:26241689"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF6">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029034239" description="Endo-chitosanase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="36563" checksum="ED1AF653F6CE9030" modified="2021-02-10" version="1">MVIKSSVAVSLSALAAVAAARDVPANVKSFYNSIRGQGQCRNVLAGGFHSIDGDSGNRSPDMKPIDFDYCGDHISDYNVIYLQGKNGQLANMDIDCDGIQHGPADDGRCGSSGDTQSVTSFADTLRGYGTGQRDLDANAHPYVVFGNTGSRKGFANFDPRKYGVEPLSVMAVVCNNKLIYGVWGDENGDDGSESMVGEASISLATACFGRGINGNSGHDDNDVLYIAFPGKDAVPGAKGAKWNAQNYDEFENSITGLGNKLIQRIGGGGGGNQPPPTGSCSWEGHCEGAPCKSENDCSDELVCNAGKCSSAGGSTPPPPPCSWEGHCQGASCRNENDCADSLVCRGGRCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0P2</accession>
    <name>A0A7D5V0P2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g072560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987180.1">
        <property type="nucleotide sequence ID" value="XM_066130970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0P2"/>
    <dbReference type="GeneID" id="90967940"/>
    <dbReference type="KEGG" id="mbrn:90967940"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="101" mass="11212" checksum="ECAE70AD0F4A20A9" modified="2021-02-10" version="1">MQRVRSCYSWRPNARPGVCDHVVHIGDVTSPPRTLALLPVVPSRPALLPSQNRLATVVPVVQVPYQANYVVLCELGLEWAVVSPTGMHPGHKEENWAPERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V103</accession>
    <name>A0A7D5V103_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g073530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987246.1">
        <property type="nucleotide sequence ID" value="XM_066130987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V103"/>
    <dbReference type="GeneID" id="90967945"/>
    <dbReference type="KEGG" id="mbrn:90967945"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="506" mass="56044" checksum="89D91AD99586E63B" modified="2021-02-10" version="1">MSTFGLDWQFSALLPGPEMERPSLFSGFSQKYFETCVLGQQCSTTLQLAESQLDELEALNILITEVEAEAAAEQDALRDTPAGALSLRYCKKAAKELEDVIQNPQRNIKWPVRLPRTAAKFGAVLSQKTILDAQRQLSKAFQMLQFAVTSKRLPERTASAFPAKKHEINTAKVKHTPTPTKIASASVELVSPQQATLRWLSGSVFGGIAGAQCSQVVQEGRDDGEEVRTAWDILSYRSSRSFTWKLTSWNVVPGDSPILEAVKRGPFTDVMALISSGDASLYDRDDNGKTLLHYAVYCRKFDTAINVIKTGHPVVETDNLGLFPCTAPSASPQADATKSLELLSVVISSGDFSNLLEGLIDDSATVAFFKPSQFDRLIWVVPGFLELIDNDLSWNFSQLPLSSKSRTFGWSMVRADTLDAILSRYSITLQDARQMLDYSVGHSLHEFAAQYLVQPNFRKTLPGSWRYAWVYDGETNGNIAVKNAQLWKGYGFGLVSAMVFDYLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V111</accession>
    <name>A0A7D5V111_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore protein fta7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g071560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987252.1">
        <property type="nucleotide sequence ID" value="XM_066130956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V111"/>
    <dbReference type="GeneID" id="26241936"/>
    <dbReference type="KEGG" id="mbrn:26241936"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43535" checksum="1345E8E04A596151" modified="2021-02-10" version="1">MAPNPERKRVRPQNASNQLKKRGRPRKSDVEPDTTRKQTQPTIRESWGSAAGRRVTAGEDERPSKRPRASDASRRSSQGAAVIGRRGIPQPNQPGPLRRATVRDDDNDDNIEASRPSPPSPEKPYVHVAPHTRRVRQSAIEAKWTPLANASLTAVSDTLQYAQRPILQRLADSEFRREHTASAVRQVAQRIARKVARGLPFPPASMPANVGRAPLQSDAGREVELNFESVLDGKLSLERQLEPALDALDVLRREKDAVEEELERDYDTLRNLEAGARAQAREQRSLLKKAHLLTPAPSAKLDGGRADAKDSDDGFVFGRRRDPGAEPGSAFTGVQDDDEIHPLVVQLGDHVDSIRGNLEQTEGILPLLARSKASLRAVLLKHLDQRAYEQVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V169</accession>
    <name>A0A7D5V169_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SAT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SAT3_3</name>
        <name evidence="4" type="ORF">G6M90_00g082430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543472.1">
        <property type="nucleotide sequence ID" value="XM_014687986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V169"/>
    <dbReference type="GeneID" id="26243649"/>
    <dbReference type="KEGG" id="mbrn:26243649"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="290" mass="30411" checksum="007CB321D5CD7837" modified="2021-02-10" version="1">MSPQYQANALFDVKNLIAVITGAGSGIGRVIAHTLAANGAKAVYVLGRRAEALETTKKTSVNPSVITPIICDVTLKDSLQAAASFVRKDAGYCDVVFANSGVATADASALIPSIGSISIKAIQEGLWQHSMEEFTESFHVNVTGVFYTAVAFLDLLDEGNKRRVVPQTAQIIITTSLGGFARKPTLSFAYGPSKAAAGHLAKQLATLLAPYKIRINTIAPGFFPSEMTQNLPFMNGGSSSHAANIPLGRMGNEEDIAGAVLFLASRAGSYIDGNVLLTDGGRGCVIPSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1X4</accession>
    <name>A0A7D5V1X4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g084880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541048.1">
        <property type="nucleotide sequence ID" value="XM_014685562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1X4"/>
    <dbReference type="GeneID" id="26246037"/>
    <dbReference type="KEGG" id="mbrn:26246037"/>
    <dbReference type="OrthoDB" id="3439027at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="254" mass="28249" checksum="1BCA988C154658F9" modified="2021-02-10" version="1">MSSSDIWSRRDSWPPTQVRLACSPPKQSEPRPLLEDIDENPLTYFLTPADNDDDMDDYGADDMLFDAGIEDSNNPPEFVRSVSPSTLDGLSKLRAKSASPDFDSDGVTTDDEADEEDYIRFSPPSSSFLTPFRGLSVENFKLRSKSPPFGRPNGFLPPAASFPAPSSPPRGRPRQALTRSYSAGSRLPPRARRLWREPSPDVWSIEEETAEDLIMDRPSTTTPALAQNNQLVQGEAAKPKKKVRFLLPPREQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V290</accession>
    <name>A0A7D5V290_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adhA_0</name>
        <name evidence="6" type="ORF">G6M90_00g090160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541674.1">
        <property type="nucleotide sequence ID" value="XM_014686188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V290"/>
    <dbReference type="GeneID" id="26245537"/>
    <dbReference type="KEGG" id="mbrn:26245537"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF16">
        <property type="entry name" value="BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE BACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="37997" checksum="E5C5CEFB39923854" modified="2021-02-10" version="1">MSTESPWSIAKTIQQSPPVDLTKRYDPSTLRNKTIVITGGANGLGSHMVRRWASHGAHIIIGDVDSPSGESLVAQLRTLHPSSTFAYVSCNVASWDDQTSLFEAAIRLSPYRRIDIVVPNAGIIQSSEGYNFENPSLVNGKLPKPSTATIDVNITGVIYTTHLALHHFSQDTSTTKCLLLIGSLASIAPLPGQTHYTMSKHAVCGLFRSLRTTSFMQSGKLRVNMLAPYFVQQSRMLPLLADVVFLAGTAGGATIPDVVEAATRLVADESISGRSLAVGPPLKDAPEGEIPVAEHEGDGRGRAAWEIYAHDYDEVDAFTFRYIHMMNRVTQLRGAFAFFLDILLKIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2K6</accession>
    <name>A0A7D5V2K6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TEF</name>
        <name evidence="13" type="ORF">G6M90_00g090240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541682.1">
        <property type="nucleotide sequence ID" value="XM_014686196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2K6"/>
    <dbReference type="GeneID" id="26245545"/>
    <dbReference type="KEGG" id="mbrn:26245545"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="473" mass="51226" checksum="05BE68FDA71D361A" modified="2021-02-10" version="1">MGKDDKTHINVVVIGYVSEPTLFAVSSFHVDSGKSTTTGHLIYQCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYYVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAYTLGVKQLIVAINKMDTAKWAEARYQEIIKETSNFIKKVGYNPKTVAFVPISGFNGDNMLQPSTNCPWYKGWEKETKAGKSTGKTLLEAIDAIEPPKRPTDKPLRLPLQDVYKIGGIGTVPVGRIETGVLKPGMVVTFAPSNVTTEVKSVEMHHEQLTEGVPGDNVGFNVKNVSVKEIRRGNVAGDSKNDPPMGAASFDAQVIVLNHPGQVGAGYAPVLDCHTAHIACKFSEIKEKIDRRTGKAVESAPKFIKSGDSAIVKMVPSKPMCVEAFTDYPPLGRFAVRDMRQTVAVGVIKSVEKAAAGSGKVTKSAAKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V315</accession>
    <name>A0A7D5V315_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dihydroneopterin aldolase/epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546207.1">
        <property type="nucleotide sequence ID" value="XM_014690721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V315"/>
    <dbReference type="GeneID" id="26240630"/>
    <dbReference type="KEGG" id="mbrn:26240630"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="31816" checksum="047DB62D2C841916" modified="2021-02-10" version="1">MSIPIRTSHSLLLATGEPPATVRVQNIQSTIQGPSDAWGRQDRPQPISVSVAVGMAQSFGPTSTSDALASDTVHYGLLSKAVLATLARLGGAQGTSSGRQLTLPAILDTIWTDLTGVDTSGQQPASPAQGPPFLKLASVKSLQVGLRLPKATLQGAGVCLTATAAFARGAMTARGIKLALCDLRIPILIGVNANERRAKQGVVANVEVDRFDEARDCYCALEDVIAKAMTDSSFETIEALLADMALRITTHLVRNHTPPADGEGWQLGIAVEKPIAVVFADAPCVELRINTNDVVPGEDVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V337</accession>
    <name>A0A7D5V337_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g096210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546711.1">
        <property type="nucleotide sequence ID" value="XM_014691225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V337"/>
    <dbReference type="GeneID" id="26241134"/>
    <dbReference type="KEGG" id="mbrn:26241134"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="25648" checksum="7F47BBA70532AFA2" modified="2021-02-10" version="1">MTGAETAGKIGYQYGRKGNKGVYFIYNNELPFSLAVTESVSRQTKVELERIKVKLVPKTTVTKATTRGRDTILELRHADDTTETLMRSLTCRLRARRPILHLCRRPCPTRTDTIGRRPFFGQTATRTFLSLAMREILRIIELSRLMPRRHLIKALPAYFEGGSLPEYKVNGKTMYGITFGQSKATGQMGNMKVFSWLIWLFKGRFLGTDKAPGINAAGTTMSATFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V373</accession>
    <name>A0A7D5V373_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Pyruvate kinase</fullName>
            <ecNumber evidence="6 17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">pki1</name>
        <name evidence="20" type="ORF">G6M90_00g095440</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 17"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546786.1">
        <property type="nucleotide sequence ID" value="XM_014691300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V373"/>
    <dbReference type="GeneID" id="26241209"/>
    <dbReference type="KEGG" id="mbrn:26241209"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="32"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="393"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI73650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="527" mass="57856" checksum="75D002BE4FC86B32" modified="2021-02-10" version="1">MAAAQQDHLDTGGRVAWLASLDTAYSPEHNYRRSSIICTIGPKTNSVEAINKLRDSGLNVVRMNFSHGSYDYHQSVIDNTRAAVACHAGRPVAIALDTKGPEIRTGNTKNDEDIPISVGTVMNFTTDEKYAASCDTENMYVDYKNITKVIEPGRVIYVDDGVLAFDVLSIKDEKTVEVRARNNGFISSRKGVNLPNTDVDLPALSEKDKADLKFGVKNNVDMVFASFIRRAQDIKDIREVLGEEGKQIQIIAKIENRQGLNNFREILEETDGVMVARGDLGIEIPAAEVFAAQKKLIAMCNIAGKPVICATQMLESMIKNPRPTRAEISDVGNAITDGADCVMLSGETAKGNYPCEAVREMHEACLKAENSIPYVSHFEEMCTLVQRPVKTVESCAMAAVRASLDLAAGGIIVLSTSGESARLLSKYRPVCPIFMVTRNATTSRFSHLYRGVYPFLFPEAKPDFDKVNWQEDVDKRIKWAVNHALELNVLTPGDTVVVVQGWKGGMGNTNTLRIVRADPEHLGIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3R1</accession>
    <name>A0A7D5V3R1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuo-49</name>
        <name evidence="7" type="ORF">G6M90_00g102800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546068.1">
        <property type="nucleotide sequence ID" value="XM_014690582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3R1"/>
    <dbReference type="GeneID" id="26240491"/>
    <dbReference type="KEGG" id="mbrn:26240491"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="200"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="470" mass="53126" checksum="B6C3B18CFC9041D3" modified="2021-02-10" version="1">MASSLQRLAGHGAKRLCLRPATQLATRPFSTTRFRKYATPEPMGTRLIPVDDDFAHPSDPYGTTQHIPGAVQKSRENSVEDRKVRHYTVNFGPQHPAAHGVLRLILELNGEEIIRADPHVGLLHRGTEKLIEYKSYLQALPYFDRLDYVSMMTNEQCFALAVEKLLNIEIPDRAKYIRTLFGELTRVLNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVHQDIPVGLLDDIYQWATQFGDRIDETEEMLTDNRIWIERLRGVGVVSAAEALNLSFTGVMLRGSGVPWDIRKSQPYDAYDKVEFDVPVGKNGDCYDRYLCRMEEFRQSLRIIHQCLNQMPAGPVRVEDYKVSPPPRTAMKENMEALIHHFLLYTKGYAVPPGETYSVIEAPKGEMGVYVVSDGSERPYRCHIRAPGFAHLGGFDHVSKGHLLADAVAVIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4A7</accession>
    <name>A0A7D5V4A7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">emp-7</name>
        <name evidence="16" type="ORF">G6M90_00g109780</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987829.1">
        <property type="nucleotide sequence ID" value="XM_066131793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4A7"/>
    <dbReference type="GeneID" id="26243265"/>
    <dbReference type="KEGG" id="mbrn:26243265"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:phosphopyruvate hydratase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Enolase-like C-terminal domain"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="15">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="14">
        <location>
            <begin position="162"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
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        <ligand>
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        </ligand>
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            <position position="187"/>
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        <ligand>
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        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <ligand>
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            <begin position="393"/>
            <end position="396"/>
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            <position position="417"/>
        </location>
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            <name>substrate</name>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    <sequence length="457" mass="49409" checksum="58945C99AD4456AB" modified="2021-02-10" version="1">MAITKVHARSVYDSRGNPTVEVDVVTETGLHRAIVPSGASTGSSRYSSIPILVQCITENTGQHEACELRDNDKSKWGGKGVSKAVENVNAIIGPALIKEGIDVKDQSKVDSFLNDLDGTDNKTKLGANAILGVSLAIAKAGAAEKGVPLYAHISDLAGTKKPYVLPVPFMNVLNGGSHAGGRLAFQEFMIVPSDAPTFSEAMRQGAEVYQKLKSLAKKKYGQSAGNVGDEGGVAPDIQTADEALELITDAIEQAGYTGKMNIAMDVASSEFYKTDAKKYDLDFKNPDSDPKKWITYEELAAMYSDLCKKYPIVSIEDPFAEDDWEAWSYFYKTQDIQIVGDDLTVTNPLRIKKAIELKACNALLLKVNQIGTLTESIQAAKDSYADGWGVMVSHRSGETEDVTIADIVVGIRSGEIKTGAPCRSERLAKLNQILRIEEELGDQAIYAGANFRKSVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4H8</accession>
    <name>A0A7D5V4H8_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">G6M90_00g097750</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="2C_system_His_kinase"/>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK1-RELATED"/>
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        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="211"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="339" mass="37413" checksum="1A0F5160DD208767" modified="2021-02-10" version="1">MSLQNTCPAIIITKPKSKSKSAALHARLISFPLPDTESDGDISTPWIALASKAHSSLDSDTPEIKDLADSLISAYTEDLVFITTPVLLCVSPLQESGDYASDEHISMPSGTSELLPQPITADQLIASLSKWIPRWRRWQEKAFAHSANISIDPSITACGPVTRSEIYAHKGGPLEEKARHPPEDPEPWANPSSLPAAVDEPGAPPSSDTCAILIAEDNKVCCLVLAKLLLKLGLNFKVAQNGQEAFDEYKRDPERYWCVFMDLGMPVVDGDTASRWIRDFERATGLEPCVMVSMHSGRRETGLKTDVFDYFLDKPIRRSGIESILRAEKEKELRLVRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4M5</accession>
    <name>A0A7D5V4M5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Subtilisin E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aprE_1</name>
        <name evidence="10" type="ORF">G6M90_00g108020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI74815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4M5"/>
    <dbReference type="GeneID" id="26243429"/>
    <dbReference type="KEGG" id="mbrn:26243429"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028889439" evidence="7">
        <location>
            <begin position="23"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="147"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="9">
        <location>
            <begin position="427"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="779" mass="84477" checksum="461DA3EEF3F3914F" modified="2021-02-10" version="1">MIWLSVSALVWAALAFAPSSGAADGGGHRGNTYAGPNNYIIECHNGRDKDVLIHRIKHRDGQVHHDFNSGIFYGVSASVPGLGGDEIRNMAGVKDVWPVQVFRHEAKENSLKPRAAPKRQPYRRAVDTSWNHAMTQVDMLHSEGFYGTNITIAIIDSGTGRQVNYTHPALGGCFGRGCRVARGANFVRNEGKYGDPMDQNGHGTAVAGVLAGNDPRRNFVGVAPGATLAAYRVVDSKGYAREDDLIAGWLKAVEDGAQIIASSAGFDGSGWAQCPMAAVVARIAASGIPCIVGNGNDSKKGLFFSLDPSTGRNVLAVNSFAHRMVSSAGGSRAVTAGMSWLSASGPTWELDIKPNVGVPGDEIPCPQIDGSYDNCSGTSFAGPQVAGMAALIAERREDFDPGHLMSLLMTTAAVQKDGHFIPVVHLAFNDTDHRAQSITIRVTNKARFEVTYQLSILPAVTIYARRLPRDFKNPEYIQAPASIDMSKTFLKLVANQSDTITISAKDPKGLEADRLPVWSGWVAINSSDGKTLTVPYMGLAGSLHKQQVLESDGVSLQGFNHDMHNADSNRGAKFSYTVKKGFTTLSASIIINLILGSRVYVEAVPLSPRKWMTDRLGKSRGFPIKGYSPRALQRYTGIGLYDKEWDGQIQSGDYLPPGDYQLVVRALRVFGDPTMEADWDAAEPLPFQVMSGAGQEACKAYQSGKGPKDALFRNLQECHQVHNKTAVDAPWIPRPQDSSKCDDDNPTEEDCGTYHYCKAHQERLDDIISPFRNKYEFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Y8</accession>
    <name>A0A7D5V4Y8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RGR1</name>
        <name evidence="12" type="ORF">G6M90_00g108890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543961.2">
        <property type="nucleotide sequence ID" value="XM_014688475.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Y8"/>
    <dbReference type="GeneID" id="26243348"/>
    <dbReference type="KEGG" id="mbrn:26243348"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="90"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121952" checksum="803681AB1D39E60E" modified="2021-02-10" version="1">MESSGHNGTRTDHDRDSSMNGVNGANGTPQDSGFPKEKASAATATDGSAKAINGNDESRSQESNQNGEAERVISRMNDLPDEIVHITQGFVPLSLLLTRLAQTSHNALQDKVAEMAKMPLPAAAANGSSSYSSSGPDDSSADNLRKKGALTNFAQEWHGKWLKALVIAEWSRKAHLVSKLIDLKFHIDQQRILYDTALDEMVNVKRDLTFARMPSPDLKTALQVLSTGNAPWMPDLGYIEPPTLTPELQLKWINELNTLLSLRLNLDDFDKIPYHFRNYEISSGRVTFKVEGEFEVDLTIADEDFEKQFWFIDFRYAFTPAASSISESLRNYLENCVNDVLGKEGLLGCYQFLHELVLTTKIHELKRQAMQLSRTSWTGTLNVEPLNRALSIQYWTGRSTTMGSKSWVIVAVNSNRSGNGKEAASSTSQLVVNWYRDNKEVKGVEIEFNVNELSAEALLTNVIARHVEHILTSIHDKLLTVARFKNHEASMALRVSRTDPAFSSLTTQVGHSGEASMLLEPMTGVFALKPPSRFTIQPEHQLNMGKNPAEDGLNCLEVLRCAVMEDELHCRATLMGWFVRKPPMAAEELKSAIKVRDWTRVICLQKDGWGSNWFVVVVLSLNGDEWWLLESNPNQASKTLRFKAKLPFNNGHPDLSDVFWENLAFFTTGVIAQSVDLRELHRQKIKSRSSNRISLSTPQTVRLPSTDVALSALFPSMVFDQSKPEEDALSNSEGQLSNLELLSLIQQASGAVLVRKKAWADNIVSITFRGIRCLSKAENADDGSKENELICTSEAILKVRKPSKFASLDGLADRDVSYNPKRGEFALRIQRAVGRPILDTLKSRIKAIDRFVNFLEALESANGTITTESVTLRQITFYYSELQTKQSSNDADQVMEDSRKRWRVVLDLSKDDIDIEIEKGNPHLRVLDLMRQLVNSDGGIGVLTAWLPASLPALQAIDKMETEWEPIQAAGQGRIEFSMKTVAWMSVEYTMASDAKTLKNPIRLQVQMQPRRSQAWWHVWRSDAEPNADDRVSTALQPIWKKRGDNWLGLSTGAAGRPQDGVVKMLLAVDEAIRSTITSGPGVTQGNEVVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6Q2</accession>
    <name>A0A7D5V6Q2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acetate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g109240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543930.1">
        <property type="nucleotide sequence ID" value="XM_014688444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6Q2"/>
    <dbReference type="GeneID" id="26243317"/>
    <dbReference type="KEGG" id="mbrn:26243317"/>
    <dbReference type="OrthoDB" id="4583914at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45661" checksum="740A3E2EFBD37C0B" modified="2021-02-10" version="1">MAGASSSSGSSFTSSSLGRPPTYSRSHVSPVDSTWTPISGVSTLSAPSTGGSVALQTSLRPLDLGPPGYQATIVLFQDTPDERTVYLGPWEVVGSEQRRVLWQCSYQNELLEHYLPSDIPSEIHPHTLHSRHRQYHDPSDMERYLTFPEPHRIRYFSDEGVCIHDQYIQVRYEFTTVDASVRFQGDLRRKDMVGFYDVDVVWTNVHGRTDSFGKVKGIGAIQRLKMWRDRYTTFHSLSVLANKTDGQYREYDVHIFDGELRSRDDRAKQLKLSVRGRRGSAPDEASQRRFSFARGVRPRVRSSGGNIGQSSSESNPSSAQPVDIRYLSIQFSSRQDYRRFLEMWLYAHSTDRDFQGIPFPPHHFELPSPQMLPGQPVELESPDWTRTLEPVAEPEESDDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM82</accession>
    <name>A0A7D5YM82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin y domain-containing family A member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Plekha8</name>
        <name evidence="3" type="ORF">G6M90_00g007240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549786.1">
        <property type="nucleotide sequence ID" value="XM_014694300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM82"/>
    <dbReference type="GeneID" id="26239230"/>
    <dbReference type="KEGG" id="mbrn:26239230"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="24785" checksum="FC7FCE531AB929D8" modified="2021-02-10" version="1">MSAPVIPPGGTIVQTFRRSFVDVPIDAEKGNAISTTEFLDAAESLTTMFDVMGSVAFSPVKSDMLGNVKKLRERQLAAPAESENIQDLCRNELKTKKHTATEGLLWLVRYSFPLMPDQELVQKLMNTSGLEFTCIALSSNVAKPSEELADSFRGAYGQTLKPHHSFLVKPVFSAAMSACPYRKDFYAKLGQDSGKVQDDLRVYLAALEKVVGILKGFLDSKDAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM96</accession>
    <name>A0A7D5YM96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.12</ecNumber>
            <ecNumber evidence="10">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">xdhA_0</name>
        <name evidence="19" type="ORF">G6M90_00g002660</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="13"/>
    <dbReference type="EC" id="1.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542817.1">
        <property type="nucleotide sequence ID" value="XM_014687331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM96"/>
    <dbReference type="GeneID" id="26244190"/>
    <dbReference type="KEGG" id="mbrn:26244190"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="18">
        <location>
            <begin position="72"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI65440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="44368" checksum="33CF9028AE87B87A" modified="2021-02-10" version="1">MTLIQPRSIPNHSQPKNEIDLIQAPAQPTAGISQWHTPDTDNSGVDLTATTTESSQDSLESAGKSNLSFILKSPHHVEFAQRPVPKISTPHEVLIAVNYTGICGSDIHYWEHGRIGHFKVKDPMVLGHESAGTVIRVGSAVKSLAAGDKVAIEPGYPCRRCDECLAGRYNLCPDIIFAATPPNDGTLAGFWVAPCDFCYKLPDHVSLPEGAIIEPLAVAVHIVKQAHISPGASVVVMGAGPVGLLCAAVARCFGAFKVVSVDIIQAKLNFAKTMGSTHTYLSQRISAEENAKSLIDQCSLGNGADVVIDASGAEASIQASLHVVKVGGTFIQGGMGKSDITFPIMEMCQKEVTARGSFRYGPGDFKLAVELVSNGSVDVQRLITGVVPFKQAEEAFHKAKSGETVKMLIAGPNEAEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPA7</accession>
    <name>A0A7D5YPA7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 15">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TOP2</name>
        <name evidence="19" type="ORF">G6M90_00g024220</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 15"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985797.1">
        <property type="nucleotide sequence ID" value="XM_066129935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26237602"/>
    <dbReference type="KEGG" id="mbrn:26237602"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="entry name" value="DNA topoisomerase 2"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
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    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
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    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
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    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
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    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
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    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 14 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="17">
        <location>
            <begin position="557"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="18">
        <location>
            <begin position="810"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1188"/>
            <end position="1220"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="1292"/>
            <end position="1418"/>
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            <begin position="1443"/>
            <end position="1571"/>
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        <location>
            <begin position="1592"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1200"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1310"/>
            <end position="1321"/>
        </location>
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            <end position="1338"/>
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            <begin position="1383"/>
            <end position="1393"/>
        </location>
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            <begin position="1468"/>
            <end position="1480"/>
        </location>
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            <end position="1525"/>
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        <location>
            <begin position="1630"/>
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    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="14">
        <location>
            <position position="900"/>
        </location>
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    <sequence length="1650" mass="184081" checksum="BD68A8B869A7E602" modified="2021-02-10" version="1">MDSDVMSDPAFSLGEESDGYVPQKKSKPKAAAKPPAKATGKKLTQTTLKTTKAPAKRPKPDSDDEDSLGGSSSGFSHTPPSSKKQKKAPPPKKSGGVPLAEVENDSVLIDVPPTKPTSKSSKTATEMYQKLTQLEHIIKRPDTYIGSVEKTDQQMWVYNKETSQMVYKNISFVPGFYKIFDEIMVNAADNSQREGSGMTYMKVNINRATGEISVENNGKGIPIVIHEKEKIYIPEMIFGHLLAGSNFDDNEKKTVGGRNGYGAKLCNVFSQEFTVECQDSGNGKRYKQTWTDNMQKMQKAKITSNKSADFVRITFKPDYDRFGMPEGIDDDLEALLYRRVYDMAGTVHGVKVYLNGEQIKLKDFKAYCDLYAKSIAAERTAEEGGTPTCTVEIDKDKSHPRWEVAFTVSDGTFQQVSFVNSIATTTGGTHVNYIADQITGSLLKALDKKKKGHSLKQSHLRNHIFIFINCFIENPAFNSQTKEQMTTKVSQFGSKCVLGDNFLKAIAKSDAIENIMDFAQKKADKMLSKSDGSKRARVSNAKLVEANLAGTRRGHECTLILTEGDSAKGLAVSGRAILDPDKIGVFPLRGKLLNVRDASLDQITKNQEIQNIKQFLGLKHKQVYTDTKSLRYGHLMIMTDQDHDGSHIKGLLINFLQVQFPSLLKIPQFLQEFITPIVKVWQGPDPKKPLRLKSFFTQPQYDEWKESHKAELSRWQSKYFKGLGTSSNEDAQVYFTNLDNHLKEFEVMKSEEAELFDLVFSKKKADARKEWLGNFIPGTFLDHSMKEITYTDFVSKELILFSMADNLRSIPSVIDGLKPGQRKVLYACFKRNLTKDKKVVELAGYVSEHTAYHHGEASLQQTIIGLAQNFVGSNNINILEPSGNFGSRLAGGSDAASPRYTFTRLAPFAKKIFSPLDEACLKHQYEDGKRIEPEVYSPILPMVLVNGADGIGTGWSTTIPNYHPADIVKNLKRRMGRLDEDGAEEKPFETMTPWFRGWKGNPEAAGPDRYKFNGIASQNDQNPNEILITELPIRMWTDDFKAKLEKVISGNDGPTWIKDYKEFNDHKTVHFEIMVDEKHLPKILEEGLLERFKLTKQVATSNLVAFDTRGQIRKYEKVEDILEEYYVHRLQMYHDRKQYWLQVYDNDLEKLKNQYRFIKEIIDGELIVGRKKKAVLVSELRDCKYKAFPPGGQKQKTADDEPDESDNEDDDDDDKATAAGAHDYDYLLSMPIWSLTQERLDKLKDAINKKKDDIEGLSAKSEKDLWSADLDDFMTEWDAQVALEQELQTKIRRMGRRESKKIGAGRNRKGKGDDDYEPEKKSKGKGKGKAAAAKAAPKVKTETKSAQRFADMFGTKTKKEPKDDVVDLSDNFSDDDFAALSRNKPSSARVTELSQSASQSQAEEPEVPRPTKRAAASKAKTLFEVSSDSEVEDVEMIGDIGSMVKGIGKPAGDKSGRLSLYAMNRPESSQGNSGSSSLQKLKTKASKSSMDIDSHDETNYEMLAKSSPHKIKDEEDAAQDSDDELAVTAASSTTDTGLAAVKKARAKPATSKAKAKPETKPRAKAAPKATTLSPAAKAYAAKKKTIGVKKIALEDSEDEVDEPPSPVSKPKPAARGRPGRAAAAKRPVIVDEDSSLMQDESDDPFEMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQL3</accession>
    <name>A0A7D5YQL3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g003290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QLI65882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129548.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26245018"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF14">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="554" mass="61473" checksum="24890AF024058D47" modified="2021-02-10" version="1">MPTTTITKKAASEFRPRRSHEKSRNGCVRCKQQRKKCDEARPICSRCNKRSHCCRYHDAAKRDSVGESAPEAAAEEDVASPSPVLEAPDLSPSGSSLWPDNVFATDSTTDSLSPYALAYMLEESDEARMPGILSSQELELLCHYITHTSRIIPFDQGDLYALHVGIPNLALGNETLMASLLALSAACKSHDIVRYSPQPLERLDEVRELLSLADRHHRTSLHHIQAAIHDVQQHDHVLANAALMVLYGSSSHCVRVSLAQMANRRGITLELELLPTQSQWMMLIRAAHTAFTGLLDVQNDINAVFGSRYLSVAENSAFLTPGLSFDNVYLAEDGPSEGTKLFLLPAVWATYGPALDQLAAKVLSLQTQAPRDSGRNLQACLAAHEILEQVFSAVFMDKETPTPHEDEAVHLGRMCSVSPWLTSYLGRVTSSTPSKPLRRTVMAFLNRVPLEYLHLVQSTLDDIPVPGNLNHLNWDDSTPMTMTSAHRLAMDIFAHWLVLVMLLDGVWWIGGIGEWELGRILSSAQARAEPGGRWWPESMYNAKRKLAQDMDKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQR4</accession>
    <name>A0A7D5YQR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AO-I_2</name>
        <name evidence="12" type="ORF">G6M90_00g002400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542840.1">
        <property type="nucleotide sequence ID" value="XM_014687354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQR4"/>
    <dbReference type="GeneID" id="26244213"/>
    <dbReference type="KEGG" id="mbrn:26244213"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="11">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="10">
        <location>
            <begin position="259"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="704" mass="78606" checksum="9E5D9E1E19CF6815" modified="2021-02-10" version="1">MTVHSNPAVAAGPHPLTQLSADEFTKARDIIVKQYGSSQSLYFRQINLEEPSKESLIPYLEAEHAGSLTADTPRPARQAHVEYDLIKVDRHELVRAVVDLDAAKVVRSDTAPPHSYPYFTTDEFTQFFDHCVASEMFKEAMTEFVLPEGFELSIDPWPHGPSDKDDDPRLMQGLVFAHDARKNHPDTNHYSYPVPIIPVMDWVTKKVIRVDRLATGGSDDGLDPVPRREKPRKLFEKSKPAEWIPELLEHPMRTDLKPLNVVQPEGASFTIQDDGLIEWQKWRFRVGFTPREGAVLHDVCYQNRPVFYRLSFSELTVPYADPRPPFHRKQAFDFGDGGVGRMANNLTLGCDCLGAIHYIDSLLSGPDGSPMPAESVVCIHEADEGILWKHTNFRTNNAVVARARELVVQFICTLANYEYIFAFKLDLAGGITLETRATGMLSVVAIDEDKASGYGNVVAPGVLAQNHQHIFAARIDPAIDSYRGTQVVVEESHGVRKNPTTNPHGNLYEVRRRVVDGPTHVDAEPRLNRTLKMENPDRKNAVSGRNLAYKLVAPATQMMLADEESVLSQRAQFARHNAWVTGYRDGEFWVAGEFTNQSRAEAGGIGDMVRRGDWFTEEGKPSGANGHGQRSSPVVWPVYGLTHNPRVEDWPVMPIEMYQIHLRPVDFFEANPALDVPSKKNESSVLVPCCGTNRVANGNGCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR31</accession>
    <name>A0A7D5YR31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HPPD</name>
        <name evidence="14" type="ORF">G6M90_00g045610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986179.1">
        <property type="nucleotide sequence ID" value="XM_066130397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR31"/>
    <dbReference type="GeneID" id="90967720"/>
    <dbReference type="KEGG" id="mbrn:90967720"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="13">
        <location>
            <begin position="205"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="408" mass="45592" checksum="7CC1BBC4BB984DA2" modified="2021-02-10" version="1">MAPSAVSPQQRPVDSGVVQPQAGNFTGYDHVTWWVGNAKQAAAYYVNLFGFKHIAYRGLETGSRYFASYVVGNNDVRFVFTSPLRSAVHLGPEEPISPEDKTLLLDMYAHLERHGDAVKDVAFEVDNVEGVYHKAVKEGAVAVQGPQRLHDAEHGSVTTAVIRTYGDTTHTLISRGSYSGPFLPGFREGKKSTASVALPDVRLARVDHCVGNQDWDEMVSACAFYEQCLSFHRFWSVDDKQICTEFSALSSIVMASPNNLVKMPINEPAAGKKKSQIEEYVIFNSGAGVQHIALLTPNIIDAVTALRARGVEFINVPTTYYDTMRLRLKTEKRNWELKEDLDTIQRLNILIDYDEGGYLLQLFTKPLMDRPTVFIEIIQRNEFEGFGAGNFKSLFEAIEREQAERGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSQ9</accession>
    <name>A0A7D5YSQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g040130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547363.1">
        <property type="nucleotide sequence ID" value="XM_014691877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSQ9"/>
    <dbReference type="GeneID" id="26239926"/>
    <dbReference type="KEGG" id="mbrn:26239926"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="246" mass="27286" checksum="3C02D6FF5168834A" modified="2021-02-10" version="1">MNPRFSLAASSDTTYHSFHDIELQEPPSPPRSRGAIDSGRAADGVNQPIQPAPPPTAVKMQRQDSGYESHQSGSARNSLSHPRPVPPSRRTSTVSSTAGAVTTARARARPSTRRSAKSYPQSGVPSPGYFQFPAPDLVELTETASRVEPPPPNLPPPTTHYWTSDSTRRLEYAAIDAASRGVKGWIRRHLVPDCFTPRHVAFDDDSGSVRRYRLELEEEQDEKACPQVRERRKGWNFFSLRKSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT94</accession>
    <name>A0A7D5YT94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541375.1">
        <property type="nucleotide sequence ID" value="XM_014685889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT94"/>
    <dbReference type="GeneID" id="26246010"/>
    <dbReference type="KEGG" id="mbrn:26246010"/>
    <dbReference type="OrthoDB" id="4939254at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="45400" checksum="662A1C2138CCF95F" modified="2021-02-10" version="1">MSPLNSPEGQYLSLAGSFQKSQKTLANNFKTWGLKPSSKNQAPTILAATEAAYTNSVKQVEDARNRQILILNEDWVDECCEQKSWIAPEDKHIWEKGGTKESLAETGSTASGEPAGKPTEDDSAKAPNPPPNPPENPQPQPPNPTENSPPQSPNPPEIPQPQPPIPPENPPKHESDNESMEVALLKKQIEDLKNSKTNGKDGPSDRYDQSEDQKECFDVFCEWSRRFDDTDDPNTNRVEVDCHPADINKPLSDRRKEYEMEIMLITQFRSYVFVIDPEGKIEGYDCLRPGYLIPRSDCPSAARKYEDNGGEIVRAKQRENLQGKQMTDFIWWSVATDPEGRFCYCLGAFKGDKRPSLYSRSTFKAKWGKLADDQINEIRRKFSQAELNKQAKARSQKLLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTH7</accession>
    <name>A0A7D5YTH7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TEF3</name>
        <name evidence="18" type="ORF">G6M90_00g073590</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545706.1">
        <property type="nucleotide sequence ID" value="XM_014690220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTH7"/>
    <dbReference type="GeneID" id="26241739"/>
    <dbReference type="KEGG" id="mbrn:26241739"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 18" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="435"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="678"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="986"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI71280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1055" mass="117189" checksum="2D51E6C8DF3BA00F" modified="2021-02-10" version="1">MPSENAQSVKVLDELFQKLTVSKEAADIKESANQLASFINGRIEDQDVPNKTIDNLKKSLTNKKDAVAREQACVAIQAIASHSEVSANVEPYLVVLLPSVLAAVGDKITAVKNAATAAVLAIAGAINGNACKAALPAIMESIRTAQKWPEKMAALDFIDALIKTAPAQLAFRVPDLIPVVSEAMWDTKKEVKERAYKTMEQICQLIVNRDIERFIPELIKCIAKPENVPETVHLLGATTFVTEVQEPTLALMVPLLDRGLAERETAIKRKSAVIVDNMCKLVDDPNIVAPFLPKMMPGLQKNYDNLADPEAREKTKQALDTITRVGNIVDGKIPEVRNDGDISVVLGKLKEILSSKYATYLEKMGPVAEYIAAMAGQLIDEKESENAVWVENLKAYVSVITGIDNAEAIVDSLRKRASPGAAEEEAVEADEEEGEDLCNCTFSLAYGAKILLNQTHLRLKRGQRYGLCGPNGSGKSTLMRAINNEQVEGFPKQSEVKTVFVEHDLDSADTEMTTIDWTMKKLGEAKVDVTQPDVEKQLVEFGFTPTMISGEITALSGGWKMKLALCRAVFEAPDILLLDEPTNHLDVKNVKWLEDYLTSSPCTSIIVSHDSSFLDNVCQHIVHYERFKLKRYRGNLAEFVKRVPSAKSYYELGASEMEFTFPEPGFLEGVKTKAKAILRASKMSFQYPGTSKPQISDITFQCSLGSRIAVIGPNGAGKSTLINVLTGELIPTQGEIYQHENIRIAYIKQHAFAHIDNHLDSTPSEYIQWRFQTGEDRETMDRANKIITEDDEKAMDKVFRIEGTQRRIIGINSRRKFKNSYEYECSCALGENVGMKNERWTPMMSADNVWLPRNELLASHQKMVADVDMKEALASGQFRPLVRKEIEAHCANFGLDAELVSHSRMRGLSGGQRVKTVLAACSWQRPHLIVLDEPTNYLDRDSLGALSKALKKFEGGVIIITHSAEFTKDLTEEVWAVMDGKMTPSGHNWVAGQGSGPRLKQDDDEEEDKFDAMGNKIVSTKKKAKLTSSELRKKKKERMARRKRGEEVFSDEDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTR0</accession>
    <name>A0A7D5YTR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="1">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fdc1_1</name>
        <name evidence="1" type="synonym">FDC1</name>
        <name evidence="5" type="ORF">G6M90_00g054640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="1">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="1"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540941.1">
        <property type="nucleotide sequence ID" value="XM_014685455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTR0"/>
    <dbReference type="GeneID" id="26246247"/>
    <dbReference type="KEGG" id="mbrn:26246247"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="3">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="2">
        <location>
            <begin position="155"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="4">
        <location>
            <begin position="364"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="543" mass="60437" checksum="90826A47EF3C510C" modified="2021-02-10" version="1">MAFVFTGRVSRPSAHLRIPRPFARSAYRAQSTTSSQPDHVAAQLDFRTFVDVLRADGDLAEINDQVDPHLEVGAIVRRVSEVNGKAPLFNNVKGAKNGLWRIFGNAASLRSREEEKYGRIARSFGLPPDSSWKAILQRSQEAKRRPPIPPRILPTGPCKQHKIFGDDIDLHKLPAPKLHQGDAGKYLQTYGVHVLQSPDGKWTNWSIFRGMIHDSRRLVCLVGSGQHNSVIRDMWLKKGKTEVSWALAFGVPPAASVVAACPVPQGVSEAEYVGAMVGQPLDVVKCELSDLLVPANSEIVMEGTFSFKDKAPEGPFEDYLGLHFSDDQHMQPLFTVNAITYRDGAILPVSVPGKITDESHVTASMASEELLELLRQHGYPVIDAFAPLETYATWCALKVDVKKLAEMRTTPEEFCNKIGNLAFNDKSSMLMNRIMLFGHDVDVGNFRDIMWALATRCRPGQDEYVFDDIPVLPLTPYMSHGRGDPTRGGKVVSDCLFPMEYEGKISFRGCDFERSYPEEIKERVGSNWTAMGFDEVESLSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUH3</accession>
    <name>A0A7D5YUH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g064610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540083.1">
        <property type="nucleotide sequence ID" value="XM_014684597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUH3"/>
    <dbReference type="GeneID" id="26247119"/>
    <dbReference type="KEGG" id="mbrn:26247119"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42090:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="151" mass="17028" checksum="92042C253D8227B9" modified="2021-02-10" version="1">MSLQLSAARRLTIKRPASLCHAYHSPPRLSLADRVPHARQTLSTRSDENTKSVHDDDVAALKDAPYCRNKTRPEDELLAAASEADAQRTVNPLEASGANTDISKLSSDMLTGEYVSIKWEEAKRERSRYGRTPGKREKLHVWKKTKKVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUI9</accession>
    <name>A0A7D5YUI9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GTPase-activating protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rga5</name>
        <name evidence="4" type="ORF">G6M90_00g087050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542413.1">
        <property type="nucleotide sequence ID" value="XM_014686927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUI9"/>
    <dbReference type="GeneID" id="26244927"/>
    <dbReference type="KEGG" id="mbrn:26244927"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="73"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="890" mass="96320" checksum="049CC8160F9BEEA1" modified="2021-02-10" version="1">MTSPIPTTNQANSSHHPSPPGATPASPPNKRDLKSWWKGFKLPSKQPDPPETKAPGIFGIPLRQSITYANVAISLIDENGKSYIYGYVPIVVAKCGVFLKEKATGIEGIFRLSGSEKRIKELKHIFDSPDRYGKGLVWDGYTVHDAANVLRRYLNDLPEPVVPLALYEKFREPLRGATKQPTSDGEGPEFVDNFDEQAAIKKYQQLITELPPLNRQLLLYILDLLAVFAAKSDENRMNSQNLAAIFQPGMLSHPNHAMAPEEYRLNQCVLIFLIENQDHFLIGMQGTAADENTKKEVESGTPTTPNAGGVNRSASTASAGANSVRKEGQLRRNRSVSSRHSRGEGSVGSHSPALATNTTGGLGRSNTVPSKKSPGLAGGKFRKADSPGHQSPARLEPMTPVRPAMAFDESREPSLTPPVAGITHLSTSTAQALAPSQERLLEVPQDSLTPPVKERNLQNLFQRLPADGSDKRQPNKLKKKRIPGSMNISAQSSNASLTHSNAASPAWESPNPMESILHVSENVTSDPAKTSPRETPVKTPQAGAQNPINSSEPQVTQSKPSLPNQASDMSSEPTPRASQIASSSSLHPDNNFTGKKSPPTSIHSSFNDGSDLDQALEGQTAPQIENPDKEKKRRWRLSRSRKDDNDGSSGSLVTPSPGNLGSNTGAETSTTTIGSGGGKTRKSFQHDGSESHLFDLHGGHDGERENGKDDPKGPIGWIKNKYREAKENAEQRRNKSPPADRHGDRQALGAALTSRGKSLDMNREKQEDDKVAEKPVEKPAEKPTEKPVEKPVEKEAREPMAVAPMHHDNPKFTEELRPSITTVPLESVPEVSKETPTEQIHTMTEMPPAELSGGQADQPEIEAPSAPVPVLPTTGETTSAETPAELPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVK8</accession>
    <name>A0A7D5YVK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g011590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693878.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVK8"/>
    <dbReference type="GeneID" id="26238808"/>
    <dbReference type="KEGG" id="mbrn:26238808"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="41142" checksum="20CD69707AD09545" modified="2021-02-10" version="1">MPNSDEGIELPQQGKRESRSLLDRAHVPGGVLAVNTKRTDDATIWGLGSSSAPTSAKSVRGVQSPGYKEAALGSAAFEIETPRVSAPSSFCLPDQLEFPPEEPNHKLPTTMKFLALTTLASGAYAGVLVQRDLATIQAAMTSAGQGIDGLGTAIKGFSGDPAPVLAASNTLIQALKDGKAKVDPSSDLTLADALGLQAPAGDLQKKGDALLADLKTAVPTIEKAGMCEVTFTQTSDINTAAKALIDSVVSKVPTAAQGIAQGIVAGLLKDLQDAQDAVGPANCKNSATPPASSSAAPPATSAAPPSSSAAPPATSEAPPATTQAPPSSSAAPPATTEAPPATTEAPPATTGAPPVTSAAPPASDTCPAASTVTVTAIDSKHCTPTPTCTKKPPVTVTTTKKACPTKTKLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVU5</accession>
    <name>A0A7D5YVU5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g080390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014683885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVU5"/>
    <dbReference type="GeneID" id="26247815"/>
    <dbReference type="KEGG" id="mbrn:26247815"/>
    <dbReference type="OrthoDB" id="4933784at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028803624" description="Inhibitor I9 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="3">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="721" mass="80649" checksum="25E8EB95E52AD940" modified="2021-02-10" version="1">MHGFLVLVFALLQRTTAQQTSGDGSSQALGHIVVLKEGLNDGHLNEHLDWVKSIHKRSLDTSNDNENQENGVKHTYHGGAYGFHGYAGSFSRDVLKSIKEHKHVDFVEEDQVIILEPTRRDENTDGDMLPEGGTRKKNKGHSLLSKGQGYNSFLEKGLILDAVILHEGEKRRDIPARSAEELVSQTTMNFNFTEPSADFAGVDVESYFYPPDLDAIMEDILADLENDEQDVSASKVLFTRAADRPDCTGALKFSSELAEDYNSYLKALDISVAATVSGWGQSASVSGSYLNQAEFSSNALTYVAKIDIRRQLDSPAGFQFNMNKYTTTTFARNFGDRWIRGFHTGGKMIARLTFRSKGTVSKVDLKAHIEASLKFWGVTADISASVKKSQEEVSKHANVEISLFYQGDLGRVMGQSGSPDKITATSADGAFHQVKSWADQFMDNACRHDYEYQPLLEEYRNAEGFPEHQKILDYRTAHRVSSMVLKQLVRISEMKQYLLNLTTIDDEIKMNVEFDEIDMVKQSQDWVDSVAENPENSQSTGRDLIKTLRDDFFKKYAPYISNSFTNESPRADSYANGNRYISGVKVERGATGPANSLGNINYGFTGGSVWLVPTYTSNPKKACTTITVEQTRIDYADAVKFLSKDGKYTARYFRCVTSSERKIRRLALSRGSGIINYDKAHGFVDATSNINEGFDMSPLYLMWSFDETDPAPEDDFPEPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVW5</accession>
    <name>A0A7D5YVW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dgat1</name>
        <name evidence="15" type="ORF">G6M90_00g018450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986005.1">
        <property type="nucleotide sequence ID" value="XM_066129820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVW5"/>
    <dbReference type="GeneID" id="26238139"/>
    <dbReference type="KEGG" id="mbrn:26238139"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="513" mass="57892" checksum="708A247C9C8AF8D2" modified="2021-02-10" version="1">MSTATTTSVSPANGTVSKGNATRRRNRNASPGPVEGESEDATAAEKPRAAVAQKKYRHVAAVHSKSRPSCLSHDSDATPSFIGFRNLMVIVLVVGNLRLMIENLKKYGVLICLRCHSYKNEDVLIGGLLYFLIPCHLLVAYLIELAAAKQARGSRKRLKPGSTGPSEQDKSKFHSTWVLVAWAHGINMTLALTLTTFVVYFYIHHPLVGTLTEMHAVIVSLKTASYAFTNRDLRHAYLHPVKGEHIPELYSKCPYPNNITFGNLAYFWWAPTLVYQPVYPRTNKIRWVFVFKRLGEVCCLSAFIWFASFQYAAPVLQNSLDKIASLDFLMILERLLKLSTISLVIWLAGFFALFQSFLNALAEVLRFGDRSFYDDWWNSESLGAYWRTWNRPVYTYFKRHVYVPMIGRGWSPWAASCAVFFVSAVLHEVLVGVPTHNIIGVAFLGMFLQLPLIAITAPLEKMKWGHTGKVMGNVIFWVSFTIFGQPFAALMYFYAWQAKYGSVSRQPMLALQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWB5</accession>
    <name>A0A7D5YWB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Gamma-adaptin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">APL4</name>
        <name evidence="14" type="ORF">G6M90_00g088840</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987327.1">
        <property type="nucleotide sequence ID" value="XM_066131338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWB5"/>
    <dbReference type="GeneID" id="26244745"/>
    <dbReference type="KEGG" id="mbrn:26244745"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="717"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="801"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1079" mass="118419" checksum="0A0721662E8584EE" modified="2021-02-10" version="1">MSSLKQFIRNVRAAKTIADERAVIQKESAAIRASFREESHDHGVRRNNVAKLLYLFTLGERTHFGQIECLKLLASPRFADKRLGHLATSLLLDENQEVLTLVTNSLKNDLGHSNQYIVGLALCTLGNIASIEMSRDLFPEIENLISTSNPYIRRKAALCAMRICRKVPDLQEHFLDKATHLLADRNHGVLLCGLTLVTSLCEADEEEGGEDGIVDKFRSFVPGLVKTLKGLSTSGYAPEHDVTGITDPFLQVKLLRLLRILAIGDPETSEQINDILAQVATNTDSSKNVGNSILYEAVRTILDIEADSGLRVLGVNILGKFLANRDNNIRYVALNTLIKVVAIEPNAVQRHRNTILECLRDPDISIRRRALDLSFTLINESNVRVLIRELLAFLEVADNEFKPTMTSQIGIAADKFAPNKRWHFDTMLRVLSLAGNYVKEQILSSFVRLIATTPELQTYAVQKLYVNLKKDITQESLTQAGAWCVGEFADALLKGGQYEEEELVQEVKEHEVVDLFALILNSSYATQVSTEYIITALMKLTTRFSEALQVERIRRLLQSHQTSLDVEVQQRAVEYGNLFSFDQIRRGVLEKMPPPQIKESSRVLGPAPTKKAKATNRKSRVLKPTEQDLLDLMDAPAPTTSGPAQTTNSDLLADILGGSASTPPPTSTSPHAPQPANVPSIMDLFGTGPNQSTTSSAQTPVGLDLMGNSSPQTQASQVELGHPCYSANDLSVTIQVQRNAEGLIQAVARFQNLSASTSLSHVGLQAAVPKSQKLQLLNISSSELYPGADATQMMRISGCKGELHSVKLSQIENVNERVRLLRLGLHNGPVKFSPGQWLDTYVPGIARAGGFTITCAPSSAASCDGLVAPYLELAVQQSPENAVAAWLWQPAEKIIGSHLHVRIGGSFVLPPPSHPQLENIERIVFVAGGVGINPLMSMLSYIAETDGFSKLDVSVFYTSKLPDRGGLESILFVQRIAALFADGRVKGTFKMYLTGSPESLQRFKRCRKAHCVMDNNVEVQEGRLSAAELCPDPRNGDQSSSLFYICGPPTMTDSLFTSLTSGDSGLNISPAQIMIERWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWC2</accession>
    <name>A0A7D5YWC2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g030380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539458.2">
        <property type="nucleotide sequence ID" value="XM_014683972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWC2"/>
    <dbReference type="GeneID" id="26247732"/>
    <dbReference type="KEGG" id="mbrn:26247732"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="586"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="619"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="729"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="796" mass="89930" checksum="55408F5E950C12BD" modified="2021-02-10" version="1">MNNNNFGDSAYAHQGPGYQINAAGGTVNNTVYNERNGTPIQGKDCWKSLAFPEMESRYYDIDAAQTGTCGWLSQHEMYREWVERNRGLLWIKGKPGSGKSTLLRHALDDAKKKRNVKENPLILSFFFHGRGTELQRTPEGFYRSLLHQLSKTPDAVSDVVSTFKEKCETFGEVGKAWQWHPKQLRELFDSAILEALKLRPICLFVDALDECGEKDATMLAQRFKDLLDSLRSTAYNSFHICFTCRPYPIVALDSAFEICVEEGNGTDISNFVGHQLSELKPTILPRIRNLITERANGVFLWASLIVKQIVSLNLKATKLEKMEDAILRIPQELDDLYRQLIEEMGSDSVMLIQCICVAMRPLSIADWQWAMVIKTDCPYSSLQECQNSPDYKPDDESIKKEIQILSHGLIEVTSNKTIQFIHQTVKDFFVEKGLWLLKPLGSVPDGISESDFAVGMAHHELSRICVRFLKMVPNTQIFLKSAVRTHDIPLSIYATIEWVPHVQQSEQRGILQDTVLQDNLLDCFPWLMETVPSPFMRFYCTAFDRLFQYSHPMSYLSHVASEFGLTGLLQAMLRRSKSVIDEKDTRGRTPLMYAAENEHEATARLLLGYGADIEANDEEGQTPLFFAAVSGHEGIVQLLLERGADVDGLGERRAHGNNKKHYEGKTPLMCAAEKGHEATARFLLGYGADIEANDENGQTPLFYATTSEYVDIVQLLLEHGADSNTKDKVGRTPLFYAAKTIRGDIVQLLLRYGADIDAEDDTGMTPLWIAYDNEKADIERLLFEHEAAENGEYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWJ4</accession>
    <name>A0A7D5YWJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539969.1">
        <property type="nucleotide sequence ID" value="XM_014684483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWJ4"/>
    <dbReference type="GeneID" id="26247189"/>
    <dbReference type="KEGG" id="mbrn:26247189"/>
    <dbReference type="OrthoDB" id="4933217at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="108" mass="11873" checksum="01F4E73649CF90FD" modified="2021-02-10" version="1">MAAENAPRQHPQSVRLTVHFTLHKKSGKILGKGVYSTNPEEMISQARGILAGVLSKGSVENLNFDIEEVGLKGDGVYFYNIKENGLPSLEYDLDEVVFLVTSHSIISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXE0</accession>
    <name>A0A7D5YXE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Maltose permease MAL61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MAL61_1</name>
        <name evidence="8" type="ORF">G6M90_00g086070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541166.2">
        <property type="nucleotide sequence ID" value="XM_014685680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXE0"/>
    <dbReference type="GeneID" id="26246155"/>
    <dbReference type="KEGG" id="mbrn:26246155"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="62"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="541" mass="59630" checksum="6072D9FF9700BA4C" modified="2021-02-10" version="1">MATDEPDFTQGGNKGTIAASQFEVAADNDIFRGNHAAQTANDHEQNMSMRYAMKYYSIAIVWAAVMAAPIIMEAYETAMVPTFFSYKAFQKIFGYRKPGTDEYFIPTYWQSGITMAASFGQLAGLYLAPHVVNHKGYRVCSAAAFICAGLFLMLGFWSMDTGRGLAVFLIGEMCLGVPWGMFQGITLPYVSDITPLKLKGPATTMINVFWLIGQMISASVMSGASAIGSLEWSVKTPMIIQYAWLIPLLALVFKAPNSPLYLSRKGQDEQARATLRRLNKDPLFNEDGALAMIRAVNLHEKKTSTDMGLTGCFHGINLRRTEIAVVSYVTQQWVGTPLMFYSVKVLQKGGLSQASSLYLTIGMYGLCIISTVSSMGAMRFWGRRSLWLWGLSGEIMCLGAIGTLSFFLDKHDEKKSGLPWAIATFLILYAAIYNFTIGPVCYTIVAETPATRLKAATNSLSRAIYIVFSVANLYLVPNLLENAPVGWGLGTKAALVWAGSATVCLIWAFFRLPETKDRSPAEVDLLFERNIRARDWSKAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXF8</accession>
    <name>A0A7D5YXF8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosome biogenesis protein ENP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ENP2</name>
        <name evidence="11" type="ORF">G6M90_00g038990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547255.1">
        <property type="nucleotide sequence ID" value="XM_014691769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXF8"/>
    <dbReference type="GeneID" id="26239818"/>
    <dbReference type="KEGG" id="mbrn:26239818"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="643" mass="72410" checksum="801A3B1867A4CD94" modified="2021-02-10" version="1">MKLSNPGTVPVYTISGASTARPLPDWLARRRKRSLKNDPEYQNRVELLQDFEFEEASNCIRVSEDGEWAMSTGTYKPQIHVHNLPQLSLSFTRHTNSLNHSFILLSSDYSKSLHLQTDRRLEFHTPMGCHYEVRLPRYGRGVLYDCHATEALVPAVGLDSEGKGEVFRMNLEQGRFMKSYQIEVGGDDELTGGGLQGGIGVGSVNVAANAENTHNLMAFGTSIGTVEFWDPRTKSRVALLAGHDGEITALDFSSSGLSLATGSSTGMVQLFDLRRPVALLKKDHGYGFPVKKLFHMTNSSQEKKIMSADKRIIKLWDEATGEPWTSVEPVVDINDVAWCKNTGMLLTANEGKQQHAFFIPQLGPAPKWCVFLDSMVEEMAEEVHTETYDNYKFLTLPELKQLSLAHLIGKTNLLRPYMHGYFVASKLYEQAKLIVNPYAWEEERMKRVKDKVEKERASRIRGTKKVKVNQKLVDKILKKQENREKVDTNAGILGDDRFAAVFEDEEFVVDETSKTFQLLNPSAQIEQPVDPKAPTRYQAKDSDDESGSEDEIRNSSKSGNDITMRVSSTQNEGQPLRDTALGSRIQKSGRVTKARQGDIGGERQVTFIPESKKKKLQEQDQPSPRQQQRGERRSASSNTFRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYC1</accession>
    <name>A0A7D5YYC1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547095.1">
        <property type="nucleotide sequence ID" value="XM_014691609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYC1"/>
    <dbReference type="GeneID" id="26239658"/>
    <dbReference type="KEGG" id="mbrn:26239658"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="25107" checksum="E7C6F9602E09F404" modified="2021-02-10" version="1">MAKPSFDIVIPLEDDAALTADIHLRAMAEDVLTNAQFPNSQAWEYFREWLARNTREHIRHSGKGVLIARDPATGDIASFIKWLEYGPGGEDTLAPRTAAVEDEWPEFCGRSILDEYANIAGDIRRRVLGQKGYFHVTFLCTDPKWGGRGAASALLRELEDMAEDAGKAIVLEGVMSAVPLYKRLGFETRQELQMMLPPRGSKRRTERYLEHTMVWTPASLDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYF4</accession>
    <name>A0A7D5YYF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">cta3_1</name>
        <name evidence="25" type="ORF">G6M90_00g010790</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549441.1">
        <property type="nucleotide sequence ID" value="XM_014693955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYF4"/>
    <dbReference type="GeneID" id="26238885"/>
    <dbReference type="KEGG" id="mbrn:26238885"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="995"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1030"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="398"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1097"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1101"/>
            <end position="1116"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="EMBL" id="QLI66023.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
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    <sequence length="1122" mass="123514" checksum="C8D93019F70F08EC" modified="2021-02-10" version="1">MAEFPKHPFLLTVEETAQALNTDIDKGLTTAQVTELQQKYPKNELDIGDTIPWYSILTKQILNAMIIVLAFAMALSFGIKDYIEGGVLAFVICLNVTIGFWQEYRAEKRMDALRALSSPSAMVLRDGKTQVISNPDVVPGDIILLKMGDTVPADMRMFEAMNLACEEGQLTGESIPVEKITENSILAPGTEKAATSEAEVGIGDRVNMTYATTVVRKGRGRGIVTAIGMTTEVGKIAASTAKKRRKAGRSMNWRKYGKRQPLVGLAKRTYDLIGKFLGLTEGTPLQRKLSALAYVLFGCAIILAMVVFGVNHFNLRNEVIIYATSLGIAIIPESLVAVLTITMVVAVTVMRKANVVVRDLSALEALGGVTNICSDKTGTLTEGAMIVRKAWIPSSHNYTVRESQNPSDPTKGRVTYSQSKDEPAVEKEEPKRDYDRERSAAVLKFDVPDEKLNPKPAKQAPEAEPETTMTDELQAFLLSAALCNLATVRYDDEEEKWQTTGEPTEIALQVFAHRFNKGKKSLETKGWKQLAEFPFDSSIKRMSVIYDAPAGEAGSIIETEQSMVFTKGAVERILDLCSYIGTGAEQQPISDQLKEDVLNQMNVLASQGQRVLAIAYRPWGGRFTAKQSSSAAEDEKLRGDVEKDLVLLGLAGIYDPPRRETKPSIGECSQAGIKVHMLTGDHPETAKAIAKEVGIIPKNLGVLPEKVAQSIVQKATDFDKMTDEQIDALEELPLVIARCAPDTKTRMIEALRRRGAFMAMTGDGVNDAPSLSRADVGIAMGSGSDVAKSASKIVLTDDKFNSIVAAIREGRRMFDNIQKFVLHLLTSNVGEVILLIAGLGFVDHTGFSVFPVSPLQIIWINMVTSSFPAFGLGREAAAVDVMRKPPQDKRRGVFTNQIIVDMIVYGVIMGACTMCTFCIIIYGANNGDLGENCNTEYTDVCDAVFRARAATFAELTWLILISAWEFKSLRRSMFHLNPDDDSRFPVFKDLYSNRFLFWSVILGGLSVFPVVYIPFLNTKFFKHKGISWEWALSVGFTITFVAGIEAWKFIKRRFHLLEDRPVQRGAWGQGGPDDQGPKFRKTLSVSSFKTWASFSRKDTGDSVSRYSSSRGNQGIVQGTEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZC3</accession>
    <name>A0A7D5YZC3_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g107050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014688645.1"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
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            <begin position="65"/>
            <end position="99"/>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16588" checksum="B091AFF939D85B29" modified="2021-02-10" version="1">MSQRAQPPTSGTHRPRAPPGAVASAVRPNLFRSQLTRRPTASSSNSADTVRLDVEVLPDSGEIVVRNQQGEIELGDPPTPILETDEPEDRDESEKERQRLAEAVKHHSINHSTVPDQPEELLEAVRASLRAKVAALADDNWMFEAEDQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZS8</accession>
    <name>A0A7D5YZS8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADP-dependent malic enzyme</fullName>
        </submittedName>
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    <gene>
        <name evidence="11" type="primary">malA</name>
        <name evidence="11" type="ORF">G6M90_00g107960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZS8"/>
    <dbReference type="GeneID" id="26243435"/>
    <dbReference type="KEGG" id="mbrn:26243435"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
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    </dbReference>
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        <location>
            <begin position="165"/>
            <end position="345"/>
        </location>
    </feature>
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        <location>
            <begin position="355"/>
            <end position="622"/>
        </location>
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            <begin position="1"/>
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        </location>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
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        </source>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z083</accession>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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            <strain evidence="2 3">4556</strain>
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        </location>
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            <begin position="16"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI69045.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="137" mass="14541" checksum="A37B3F02BCA595E9" modified="2021-02-10" version="1">MKAVPFISIVTLALASPRITDTSIAPNSSTTPAPTPPDGTYCECGYTYCASVLMAMKKPWTTKQLAEAYCATQNAVCNSGKPSTSINSALYICLCEDPGQKYGKQLDLLCGCDECLVVGPDFRGRCETPCHAGQCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI70145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25235" checksum="5B2F865D65650B87" modified="2021-02-10" version="1">MLSRMAVTSPVTVLATRAFSTALPLRIASSKPTYNASSPNPRGPVRSNPLVGNYAPAEPTKPRDKPTHSTSSSPNASVPPPPPPPASAAPAIPEPQENPAHAYDAVSRTNITIDLANIISEKASSYAYKRSASNPMDMPKVRTKAVSGRTVFIQDRLSPTSAPTPMVALRVLEKMCRDQKIKNKFHSQKFHERKGLKKKRLRSQRWRSRFKTGFKAAVNRVMELKKQGW</sequence>
</entry>
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    <accession>A0A7D5Z230</accession>
    <name>A0A7D5Z230_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g043000</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="207" mass="22914" checksum="5619E5068AB30D0D" modified="2021-02-10" version="1">MDESQQWVAFARSMPSREAEKFKSHCSSSGLQMLQMPKSGHSHLFSGKKAQDGLRSPTSGPQPNSTTSRDKNNKNSPTCLFSRLFNPHDPPSSIYSQGHVRIRPVVAEPYDRLFSQPGNDEQPGPPPSEQLWGNVNARRPSRNVPDTRPLRAQQEDAQIASGQFEVNRRAVLASQAGQELPEGMSRDSIPRCTPLEAYRCSSGADRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z243</accession>
    <name>A0A7D5Z243_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U4/U6.U5 small nuclear ribonucleoprotein component snu23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">snu23</name>
        <name evidence="7" type="ORF">G6M90_00g024790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548102.1">
        <property type="nucleotide sequence ID" value="XM_014692616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z243"/>
    <dbReference type="GeneID" id="26237546"/>
    <dbReference type="KEGG" id="mbrn:26237546"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="27232" checksum="6E6D861E2F5B63B1" modified="2021-02-10" version="1">MTDSKKGSAYGAPAGDTDFRKTWDLGEYAAKAKEREAKEKEEAKARYEAKLAGKKYHKPLTGDETYTTARRNVIDLTAQVGKTQLVPAGAGVGKRGRSAGFYCESCDLTFKDNKQFIEHLNTTQHLLNTGQTTEVKRATVEEVHERISYYIRKKEELEKEKATSLQERLHIREEEREKELEERRQRRRDEAEKKRKEKEDAAKVKTEYGEDVRIEGEHDEDDMMAQMGFTGFGSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2P9</accession>
    <name>A0A7D5Z2P9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g056400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544232.1">
        <property type="nucleotide sequence ID" value="XM_014688746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2P9"/>
    <dbReference type="GeneID" id="26242644"/>
    <dbReference type="KEGG" id="mbrn:26242644"/>
    <dbReference type="OrthoDB" id="4937413at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="47999" checksum="0ABF3769CD8483DD" modified="2021-02-10" version="1">MSLQQNTMESERPGPSKNYIERLPSEIFGIIIETFYEMVAPKGRNKALIPLCSVSKNFLASAQRLLYRDPEVYSTIPSLRSGTKEMLWCIKRLRLIASGIIKNRQLANYVKVISLTIDRKTRHGPGFINKGDMQCLAPMLPDLQKLANETPGRRKLLPVEDGDNIMDAFLEALCALCPNAKRIYLIMPTVLRGFPRLLRLASDLDLLPRLILSLPEPEGEVAKFATWEFCKTKGSLHFTLKLQESALFLYRDIIQGAAVYDLVSLKIIAGEQTLPDDVEDFFSTFNTHKTIKELTLSWIPQHSGNPSLYPRSSYFSLEGLQNLQRLYIKSSILEAALMGAPSGSFARMLPKSLEALYICGDCEDWQLTALRDLARGKHLPNFYSVLVDEIVGSADLLKECCNEMASAGIGFNFTPKQLGQEESPIEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2R8</accession>
    <name>A0A7D5Z2R8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar import and degradation protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vid27</name>
        <name evidence="5" type="ORF">G6M90_00g044590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547792.1">
        <property type="nucleotide sequence ID" value="XM_014692306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2R8"/>
    <dbReference type="GeneID" id="26240355"/>
    <dbReference type="KEGG" id="mbrn:26240355"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="269"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="448"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="832" mass="93678" checksum="1795B4E8E9FDED22" modified="2021-02-10" version="1">MFMLRNVGKLIFGSGTQEALIELPQGQLYLVRPLSPKGYSELIFKDSAIRIRRTNQDFHYQLVVQRVFEEGEAELIADEEGEDAEIDALAAERDEKTFLLDEALRFRVESREGGETVFAWRDLSGDNGDLYEFVCDTQVPTAQVEQFVQVAQQCQYERKYRKPHTTASDEDYQQFEFHDENPIPPASPLHSPVLARSIESVDDMYAKKTAANTGAKREPLAAAAAASLPEPEPEAESEPELEPELEPETKGSGQSKAPEPDSAPEPLEIYASLPAELHLFDPQPGHFELIDDSVIATVSEVGQWQYWLQIESKERSWVGTSVVPEFNPVFDFEYLSFVFNHFSGDGTARSWLLRFKDQPTLEKFQEAIMQAIWERLNETKWAKVQEKEREYVLDAFGDLNMEDAPPLEEEEEEEEEEHEEEEDAGIRSDDYESEEDEEADEEKTGGDINSQLAVGYKHDRSFVVRGSKIGVFSHTADNRLKFNTNISRVTTPGGKLMSPKKVMLHSEDRDLIIQNGVDANKLYRMDIEYGKVVDEWKVHDDIPVVTFAPENKFAQMSSEQTFLGVSSNALYRVDPRLSGNKLVDTDMKQYASKNDFSALATTEKGYIAVASNKGDIRLFDRLGIRAKTQLPALGDPIIGMDVSADGRWILGTTKNYILLVDAQQKGGKNDGKLGFEKGFSADSKPRPRRLALTPEHVAQVYHETGKPVSFTPAKFNAGEGAEEKSIITATGPYIVEWDLKKLLRGVKTPYKIKRYQDEVKADDFKFGSDKNVIVALPNEVNMVAKQSLRKPTRESIMGDLRLSGGRRSSGRISNSQSGRYKLGRDDIVNSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3W2</accession>
    <name>A0A7D5Z3W2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS efflux pump atnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atnC_7</name>
        <name evidence="7" type="ORF">G6M90_00g099580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987633.1">
        <property type="nucleotide sequence ID" value="XM_066131564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3W2"/>
    <dbReference type="GeneID" id="26240814"/>
    <dbReference type="KEGG" id="mbrn:26240814"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="524" mass="56985" checksum="81526018C70F1990" modified="2021-02-10" version="1">MSTEDPIRDQDTGSLNTDDFSEELHPFLPSQSARQKLRFTGTKYHIYLLFFILAGLDSTVFVLNLPLTRVYESIACYQYFSTHEPRRYLDPGSIPEQECKIASVQEELARVKGIEFLFMMVPGLLLAIPYGILADRWGRRPVLLLCLLGLALAIAGVLMVCWFWWLVPLRFVWLCWLLTGIGGGPAVLSSTIYTMLADIVSPAKRANTFLQLTVAVLISQAISTPLASVLMANYGTTLPIAFGYGLGLSVCFMCSFVPETVHLGTSKNAEELPFDEAAIASSHVAKQNWKARIIGLFSPKSSGLSLWLLSPTLLASLAILFVDSFNASTINILVQYTSKKLSIPISSVGSLVTIRAAMTIIVILLVVPYIGRRLETKWRLDSHSRDLWLARITMSICPFGFALLAMGQSVIAIAVGMVLVATSWACCSSLVRSIATAMVSPERTSGLYAVINVFQAVGALVGNPLLAELLAVDVRSGNGWISLPFGLAGVLSILSCAIIWAVRLPPTTGSQRGLFLRGGDADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z441</accession>
    <name>A0A7D5Z441_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase tropI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tropI_3</name>
        <name evidence="3" type="ORF">G6M90_00g076100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545491.1">
        <property type="nucleotide sequence ID" value="XM_014690005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z441"/>
    <dbReference type="GeneID" id="26241524"/>
    <dbReference type="KEGG" id="mbrn:26241524"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="34170" checksum="20D4E2BD17199F7F" modified="2021-02-10" version="1">MTEVDIATKAPESDAQEQQTEQRPETTTPAEPPAQTGEHCVTDRPTPSGQSSTGEIIKLNDVDVYISKPSDYPHAHSKLLLLLTGGTGIKSVNNQIQADKFASEGYLVLMPDLFAGDSVPLSTAITDSSSSIIEQVKLQAVGVVKSFIIDMWLARITPDKVMPILRKVIEAAQDQYADAIKNGEGIYAVGYCVGGRFVLLLAQETEEQGSDEEAGALKKGPYIKAGALAHGASVTPDDFNNLRAPLSLVCVENDNLFPDEVRKVGEDAMSKANLEHEVQVYPGVPHGFAVVGAYADSAITEAQTTAYEQMLRWINEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z487</accession>
    <name>A0A7D5Z487_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">54S ribosomal protein subunit img1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">img1</name>
        <name evidence="4" type="ORF">G6M90_00g014910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z487"/>
    <dbReference type="GeneID" id="26238477"/>
    <dbReference type="KEGG" id="mbrn:26238477"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="216" mass="24344" checksum="B28A3005BBF33954" modified="2021-02-10" version="1">MNFAPIRRPMGCLKSVFRQARQQRTAQRSLATAAVAPTGNKAISERQRAAHGKVEKFEIYPQIPSIRSTNPDPMPILRQQQLAQLDPAGARTRLFSKDHADSAKVGDVLMVTTQGGEPFSGAFIQIRRRGVDTAILLRGQMMKTGVEMWFKVYSPSVTGIDIIWRRPKRARRARLTYMRKPKHDMGSVDNLVSAWKRERYALRSKSKQAGGKKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Y6</accession>
    <name>A0A7D5Z4Y6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g061300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542738.1">
        <property type="nucleotide sequence ID" value="XM_014687252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4Y6"/>
    <dbReference type="GeneID" id="26244687"/>
    <dbReference type="KEGG" id="mbrn:26244687"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028864611" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="173"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="41487" checksum="0655C8BCFE1F5B25" modified="2021-02-10" version="1">MWLQAALSLAAWVTAAVADDSKDLGSVLAANKNLTKFYELIKKYPDVLLELPSDNGVTIVAPSDKAMANIAYTALQPLWDDDDKDKTTAILQYHVLDGAVSAAALRDGPTYLETSRLTSPALTNVTAGQGVLVTRQRDDVVFTSGGGSRSSLVEADIPFAGGLVQVVDNLLVPPAQLAGTADAFGARSFLGSLYAARLMPALAVRRDVTIFAPLDDAYGLVGGTLRGLNASRLARVMGYHVVPGRVLSSAQLANGTGYDTLATDAAGKPARVLVRQEGNSKFVNAARIVQPDILLANGIMHIIANVLNPDAERAAPDPSAATQAPAFAVSTVSGVFTSDLPCTADCPATTTAATATGGADSSGATPTTTSSLFSSTSRGGGARCTAHVVGAAVGMVGLGAGVAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z592</accession>
    <name>A0A7D5Z592_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UTP14</name>
        <name evidence="5" type="ORF">G6M90_00g038230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
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        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Utp14"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="98"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="153"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <begin position="180"/>
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        </location>
    </feature>
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        <location>
            <begin position="257"/>
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        </location>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
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        <location>
            <begin position="453"/>
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        </location>
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        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
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        <location>
            <begin position="495"/>
            <end position="525"/>
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        <location>
            <begin position="573"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <begin position="593"/>
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        <location>
            <begin position="648"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI66829.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="885" mass="99114" checksum="0F0EB2937DE38D49" modified="2021-02-10" version="1">MPGRQSHGRSLMAAPKAKAGGKKGSKARSQKNALNAFGIAQDMYPTKYKRTPRARELDAEIERKHGRDEAGEDEDEDEDEEEQPRRKKAKGPSRADGDGEDGSDSEGNEWRLGGLRDDDEDSEIESDDAFGDSDNEKFEEYSFRGSKSKPQDDDSEDDSNDDEGETLGADAIDLATALDQWEEESDDEPEADDESGSGDSEEDGDESEEDAESDDDESEDDDDTEADPEKLNALKGLISQYGGENDDDKTKSSAGQKLSLKDLGLSGLNDPLMKKSLKLMNKETKEKRPGVAQKLAVPLSRREQGRLDRSVAYEKTNETLDKWTETVKQNRRAEHIVFPLPQNSATAGLDTSEIQPLSSAKPSNELESAIMSIMEQSGLSMNKEPKPKPQEYDDEGNLLSRKEVLARKRMERELNSREAKRAKRIKKIKSKAYHRVHRKQRERDEMAAKEAMEEAGEIDSEEEREAQDRRRALERVGQRHKESKWAKIGSKAKRAVWDDDFRTGLTEMARKDEELRRRKEGKAGVDGDSDSDATSSSGSDDEDDIRRQLRELEEDDDEPQSKLMSMKFMQKAEAAKKQANDDMIRQIRRDLDGDSADDSDDMQADDEVGRRSYGTADSSAKPALDTSTRAPKRSRVPGPQDTDVDIIINNTTATTKQPPEPSSSTTGAWSRGETRRKKSAPLRGEDLDLSANVLVASQPKSRPTNSNSNRDSDSRKNDSDEDGSEAEQHMPLAIRDQALVARAFAGDEVVAEFAREKGEIAEADDDKVIDNTLPGWGSWVGDGVSNREKKRHQGRFLTKVEGIKKKDRKDAKLDRVIINEKRIKKNDRYLATQLPHPFESRAQYERSLRLPVGPEWMTKETFQDSTKPRVLMKQGIIAPMSKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5F7</accession>
    <name>A0A7D5Z5F7_9HYPO</name>
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        <submittedName>
            <fullName evidence="7">Pumilio y domain family member 6</fullName>
        </submittedName>
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        <name evidence="7" type="primary">puf6</name>
        <name evidence="7" type="ORF">G6M90_00g097610</name>
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    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="ARM-like"/>
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    </dbReference>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="73"/>
            <end position="449"/>
        </location>
    </feature>
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            <end position="211"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="638"/>
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        </location>
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            <begin position="20"/>
            <end position="34"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="687" mass="75997" checksum="87BD24EE6E006A71" modified="2021-02-10" version="1">MAAKPVAAGKKRKATPSGKGRSDSKKARFEESKAAKTASAKSGDLSDSDSEDGGVKLNTGDEKKSSKKTDSGANGDTFDRTGLTSRESHAKQKQLAQERKAAKPLADEVQRTKKIWERLRRKSHVPKEERQKLVEELFGIITGRCRDFVLKHDAVRAVQTALKYATPDQRRQIARELEGSYVQLAESKYAKFLIAKLLVHSDDEIRDLVIPNFYGKVRKLINHPEASWILDDIYRTVATKEHRATLLREWYGPEFSIKELTKDTKLTADLKEILAAEPSKRGPIRKTLLEMVNSLVQKRMTGFTMLHDAMLQYFLTTQPGTEEFSEFVEMVKGDESGDLLKNMAFTKSGARLSCLLLAYASAKDRKQYLKAYKDTADTLVAMSGDPYGHTVILTAYDVIDDTKLTAKSIFPELVGEKDDKQAQNIVAAANNPNARTTFLYLFEGLSRSLFPASHSFDHEVLKQVHEIRKTTSKKDEDIRRQELIAALSPQLLSVIEQAAADLASTAFGCQFVTDALLSGTGDKTKALEAIAQSAIGDPKEQPAEDDLNAIPHISATPFGGRMLKSLIQGGRFDKATGKIIPVDPPLSFSDTLYPVIKDYVVDWATGPSSFVVVGLLESNDFSSTDELRRTLKKNKEVLEKAATEMTPDQKAARDAQEEKADKGGKKSKKRPDAPVGNVGSKILLDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5X6</accession>
    <name>A0A7D5Z5X6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GOX_1</name>
        <name evidence="7" type="ORF">G6M90_00g045510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="90967710"/>
    <dbReference type="KEGG" id="mbrn:90967710"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="367" mass="39594" checksum="C85AC02CF4410908" modified="2021-02-10" version="1">MDPKENKRWDSATAFYWPIISRQNLKHLNGTVSKLLWKDTNAASGAEAAGVEYLGPDGKRRIAKARKEVIISAGALRTPLVLEHSGIGNPNLLKQKGVKVVVDLPAVGENMIDQALSSFFYTTNATVKGYTPYSTFVTAADIYGSTIDKVANDTRAKLGPWARQLAQASHGGLNASALERVLEIQYNAIFNTHATLAEILSAAQGDKIGTSYWDLMPFGRGSVHMSSIDDINNPVIDPRYFSIDFDLATQVESGKIGVEFWATSPVKEIITGQFDPNATVLPPGATDEQWNKFLADSSSSNSHAIGTASMMSKELGGVVDSKLKVYGTKNVRVVDASVLPMQFSGHLTATVYAVADRASDIILGRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z784</accession>
    <name>A0A7D5Z784_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g068110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987145.1">
        <property type="nucleotide sequence ID" value="XM_066130863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z784"/>
    <dbReference type="GeneID" id="26246674"/>
    <dbReference type="KEGG" id="mbrn:26246674"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38658" checksum="F3878874EDEE024F" modified="2021-02-10" version="1">MAHEGDVESQSNPHEETPLLNGEPSSPRVDDPESEPGRGRWSYWRLFWAVLAVVVAIVFIKGWIDAGSDVDFDLKHALKKALGGGLSGAAAMVLQVLLLMPLRTIMNYQYRFGTSFTTATQTLYHAGGLGRYYQGLTAALVQGPLARFGDTAANAGILALLQSNSYLSQLPSPAKTVFASLCAAGFRMVLTPIDTLKTTLQAQGPSGIDLLRQRFQKYGIATLWWGAFATAGATFVGHYPWFATYNLLNESIQEPPKSELFLWLLRLAFIGFVASLISDSVSNSLRVVKTYRQVNDTQVSYTEAVKLVIQEDGVLGLLGRGLATRILCNGLQGVLFSILWKIFLDIWEKTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8G3</accession>
    <name>A0A7D5Z8G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rhomboid family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g107840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544059.1">
        <property type="nucleotide sequence ID" value="XM_014688573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8G3"/>
    <dbReference type="GeneID" id="26243446"/>
    <dbReference type="KEGG" id="mbrn:26243446"/>
    <dbReference type="OrthoDB" id="5411041at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20840" checksum="A1A13A1748295E2E" modified="2021-02-10" version="1">MSQERPTEPALPPRSPIIHNIALAGAIITPLVMLLPPRKMDIRFFVLAGTFSLATNQLAYEYTGQSIYGRFGNRVGNVFDNSLPEGARKTQLLLREQKEKEAAEKQRQMQEKNKTAGMVKDIWMGGESEDWQEKRAEEHRQSMEEGKGLSGIIFEQIADVWNGNYGKKAAKKEEDATASNKSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8M6</accession>
    <name>A0A7D5Z8M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g085160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987279.1">
        <property type="nucleotide sequence ID" value="XM_066131268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8M6"/>
    <dbReference type="GeneID" id="90968084"/>
    <dbReference type="KEGG" id="mbrn:90968084"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="231" mass="25295" checksum="92B309FA34C3FF1E" modified="2021-02-10" version="1">MNETPKPKQAACLVCRRSKIKCDGASPSGRCKRCVQLGTECIRPDFHAGRQKGIKNKRVGLEKALFQVEQAVKRARIGQQQSPEDDKVLTQMRALMGHLDGNEWSPSQASNHQASGEAEDSSSEYEEDMADQTSISEDIVQRTEETLAVDDAENPLQLLARASYFQPSREVRSRSSPQQSRRKGAASGKSPEAASLEAFFSGAKVNLDVGNDIDPIELGLVTEEEADSLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9D7</accession>
    <name>A0A7D5Z9D7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g101060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546239.1">
        <property type="nucleotide sequence ID" value="XM_014690753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9D7"/>
    <dbReference type="GeneID" id="26240662"/>
    <dbReference type="KEGG" id="mbrn:26240662"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="286" mass="32489" checksum="3867AC025692F666" modified="2021-02-10" version="1">MVSVQPGMQANAQQVQDDLANLFSRNLTFNPDFHVSAQKETARQEPTPAAPVSQPIVYSISQHYHHSAHTAKPGAQLSENQGQYQPQRPSSEPPQSEISPMEMILRSYGVDPAVLTPSQVQLFRVADDPQKLRLIELWSICPPNRAEDIPSLAWSSTTLDQEEHLAQMRYERQRNPTMSLDGTLVQTDNGKWTQQVSAESEPYMITGYEELMRREYERQSIDTNARDVYNHYGTAVGSNRYSRSTDPVYKGPDYDQQQQQLEMAVQYGAFEQFRNASMPVDAMDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9M7</accession>
    <name>A0A7D5Z9M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADH6_2</name>
        <name evidence="13" type="ORF">G6M90_00g080850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539437.1">
        <property type="nucleotide sequence ID" value="XM_014683951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9M7"/>
    <dbReference type="GeneID" id="26247756"/>
    <dbReference type="KEGG" id="mbrn:26247756"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38645" checksum="15805C4AC14A4124" modified="2021-02-10" version="1">MATDTAFEGWVGEDASSAKGKMVWKQYTPKLWEETDVEIKITHSGVCGSDLHTLRSGWREAPYPIVVGHEIVGVAIRVGSQAEGDIRVGDVVGVGAQADACLNRDSDYSCIECSEQSENYCARRVVTYASKHRNGSKTQGGYALYYRGPSHFVVKIPAGLPPQLAAPMLCAGVTVYSPLKRYRCGPGKSVGVIGLGGLGHFAVLFAKALGAKEVIGISRNQDKQKDAMDLGCDGYIATAAENEWATNNARRFDIILNTVASVKMPFSDYLGLLRLGGTLVQVGLPEGPIPFTPSRLGGAGARVAGTNIGSPSEIREMLDLAATKNIKPWVEQRPMKDANRTILDFEAGKPRFRYVMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAH3</accession>
    <name>A0A7D5ZAH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g084570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543673.2">
        <property type="nucleotide sequence ID" value="XM_014688187.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAH3"/>
    <dbReference type="GeneID" id="26243850"/>
    <dbReference type="KEGG" id="mbrn:26243850"/>
    <dbReference type="OrthoDB" id="5361565at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="93"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="583" mass="62839" checksum="5DF21D2E28048669" modified="2021-02-10" version="1">MGIEATEVLLDAVDVLAPIRFFTVFAPRILQDRKRGIWHTMMPFFAPKLLLETSWTLLLAIFLAAGVVAQNCVPPPIALPIKNVTLSTGKIQRGVFLTVAEPEQSFAFLPYWRVNNTFLYGPACDSLNLTWEGDSCVTFRGGVYKPADSTTKGAPPSSFKPPTEPWSSKTYKFFSEKFNVASNVSLDNFVFANPVDYTGWDLQGYDPLNMIGMDRGSTLMSTLRSTGRIASSAFGFWWGLDGVEDDDQQQGSFVLGGYDKAKTYGDGTTMLLSHHPDCPTSMMVTIQDITMNLANGTDASIFSKENGGTALLACVVPQRATLMDMPRSPYFDNLLGIIGNTEAGRSTGIDWWTVIMEPSLGIYNGGITFKLGGGISIKIPNHQLVVPERKIDKDGNLYVNASRPVIRINSLQNTTANVLPILGRYFLTGAYLMGNSGAGKFTIWQANPTTDQSLVAVNDGNEVFDPSKTCATTPTASLSPNGPVGGTDKASGSSGNSTLSSGAVAGIAVGAAVAALACAASIWLFVRKRRASLNQQQGRRTEDAVREPKADGEAEYPARAIPHFIPQELPAVGREDPPMEMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB48</accession>
    <name>A0A7D5ZB48_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g095790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
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        <property type="protein sequence ID" value="QLI73526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26241174"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="11">
        <location>
            <begin position="238"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI73526.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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</entry>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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            <end position="25"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="91"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    </evidence>
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        <source>
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</entry>
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    <accession>A0A7D5UPD0</accession>
    <name>A0A7D5UPD0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
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        <lineage>
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="QLI63516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
    <sequence length="293" mass="32953" checksum="89EB0487602AC7A6" modified="2021-02-10" version="1">MTTPASSAYPSTHASEAEVDDVGNIPIASLTLDTPLIPLRRKSRVPEKPFRFLDLPSELRVKVYEHYWSNAEKVLDLDPGNHKRYHRALGLVRTCKQVRAEATHFFFSSRAIRLFPTFPGKYFKSRKPLLARLKPSQRRCITSLELRLGPGWNAPPRGWVVNDALGLKDCSNLRKLTVYVECDPSDGIYEGFRRSEGFYEGFCRNLLGDVLGEIPGHVAIEFEGYPGVKKSGAMMRGLLEVAAQSKRKILWGPERGWTDGPEKEEKRNADAAAQLFDGIPREGYAPHNMLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPE6</accession>
    <name>A0A7D5UPE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g017820</name>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="136" mass="15073" checksum="5E7A1E1A0E01AA14" modified="2021-02-10" version="1">MFQHVSIRHIPALYFAFANCVGLVMDPLSGPCSLIELYGLPPAIADVPETWPVWRAGQGRIILLGLLMHVFYWRRQYAVCDVLLVGTAFLGINDCMVVWHNGDKTWAWIRLFGSFAFGAAGFFGLTQGPGAKNKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPV9</accession>
    <name>A0A7D5UPV9_9HYPO</name>
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        <recommendedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
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        <name evidence="3" type="ORF">G6M90_00g002800</name>
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    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687317.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244176"/>
    <dbReference type="KEGG" id="mbrn:26244176"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="89261" checksum="D0FA6953E0E18F11" modified="2021-02-10" version="1">MAGTSPTVDGLINPGLTQSRRDAAQEEGHGSPIGPDLGSRPNNRSTEETEADRGEHSRPVASYLPSWEHNITHPTTDTETPNIESGDQPQAPDDDGGSRDSSSKYIEPVESEEAAKLGYPSLNFRFLILADWILVLTLIIWLLVLGGVITLTVLQMKDPSRLHIRVESNYYALRYGPSIVGLFSTNWWRAITQGYNRLIPYVVMANVRLNAGSKDRNEAIVAHRLNNADANTMDVRLIPELWKSRHLTTLAVNLLSVNILILTPLKTSFLQLTKDSTGWGVEVSPTVGWIIVACYSALSGATLAIMIRLHGKVTGLKWSPCSLAAQIALLQYSDVPRLETCEGLEFDTRRLVVERMKAWTRDFGVLRLGYWRDVRDPSKLFYCIRFFKSDEGPSPGPLERQMRARIRRGDTQLYRYALRDQDYAESEAPVAHFTESQINFLERHPKPLSYFRYWFLFPTFFFSDWFIVPIWTVLLGALAALSATLGTRAVLLAHSYAGFARSSFVRSLVFSFLPSALFSSCNMVLLQSDTYHRMLQPIRAMDQPAPGRESVLLDYMSADPVTAIITACRRGHLRIAWGLLVALVCGVTPIVSGSIFIFDLTSQTFRASPTPTYAALGIACVYMLALPFARIDAKYVAGRGLWNIVDTLSLCYDSPILHCPEFATQGKRDDEDIHLQSQIIRQGRLYQFGYYLGDSGRRRLGFSVARLVPSRQGENGGPQTDLVTSEEYAVRGNSPEPESFDGVDRVKSRFGFFRFVLVWLREPAIILGVTPDRMRQDDTEMNVMRGASGGGQEDERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ18</accession>
    <name>A0A7D5UQ18_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g003010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542782.1">
        <property type="nucleotide sequence ID" value="XM_014687296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ18"/>
    <dbReference type="GeneID" id="26244155"/>
    <dbReference type="KEGG" id="mbrn:26244155"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="105" mass="11905" checksum="BE86F151D6B8178C" modified="2021-02-10" version="1">MASHWTYGENFHFWSHVIPEMFDDSDPPGQNFTWGRAAEMMKEKYGQTFRTYKGGTLSSRYSRKRDAYGKIYSGKALAKKVVESLPGQQAVESLQGEDSGATKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQD0</accession>
    <name>A0A7D5UQD0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g008010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985718.1">
        <property type="nucleotide sequence ID" value="XM_066129641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQD0"/>
    <dbReference type="GeneID" id="26239151"/>
    <dbReference type="KEGG" id="mbrn:26239151"/>
    <dbReference type="OrthoDB" id="4779214at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39716" checksum="2103CB3BDD7AB7F3" modified="2021-02-10" version="1">MSGLVPVTFDGAIENDAACLGPKTVHGLGLRPTAVAVAEQLLRRKTASDLNQFWGSIATYCSLNSSKAAALAAASASSSSDSLIAIDMSSRQVNRLDSSRLSDRHHDYYTSERQSGRSAMSKVPDQENMPQGLNESYYRETAAALGMPMDDGSRSHSVPPPTSAVVRYPRSPSISSSRSSSRSYCSVSRDNEHSPGSMNQTRGIIQSNFSQTRAGIGAGIVGAVIGGLVAKQASEAAFRHKQKQTGRPRRHSSETIPRMASTVLGAVAGALGANAVTHRWEDARERNRSQQLTWGNRYDREDDTTHYDTGRLQDWNHANGKGYLSDAHDYHHVYRRERQQDDHHSRRRRIEESQLYHYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQW1</accession>
    <name>A0A7D5UQW1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g023800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548176.1">
        <property type="nucleotide sequence ID" value="XM_014692690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQW1"/>
    <dbReference type="GeneID" id="26237620"/>
    <dbReference type="KEGG" id="mbrn:26237620"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="245" mass="26782" checksum="64F1248007030BAC" modified="2021-02-10" version="1">MFMARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATSEGVILGVEKRVTSTLLETSSVEKIVEIDRHIGCAMSGLQADARSMVEHARVECQSHAFNYNEPLGVESCTQAICDLALRFGEGADGEETIMSRPFGVALLIAGFDEQGPQLFHAEPSGTFYRYDAKAIGSGSEGAQAELQNEYHKSLTITDAETLVLKTLKQVMEEKLDAKNVQLASVTKEKGFRIYTDEEMAAVVERLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQW7</accession>
    <name>A0A7D5UQW7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">vps36</name>
        <name evidence="12" type="ORF">G6M90_00g021340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548413.1">
        <property type="nucleotide sequence ID" value="XM_014692927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQW7"/>
    <dbReference type="GeneID" id="26237857"/>
    <dbReference type="KEGG" id="mbrn:26237857"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000165">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000527">
        <property type="entry name" value="Vacuolar protein sorting protein (Vps36), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031558">
        <property type="entry name" value="Vps36-NZF-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16988">
        <property type="entry name" value="Vps36-NZF-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="588" mass="63552" checksum="440EAA8811755B22" modified="2021-02-10" version="1">MALDLKDIDRYDFYAGFLKSSPKITIFPKPLKRSSLHSRALSNAVSPSRNDSASPGQRDSAHRPPPEHPQVTTATWVCTICSFSNPIPVNFDPAAANAHTPLPPCLACGIKPTLAHVLKAAINNASQRPTPVINTSSGFSSLSNRQHESDALLATSTNPLDSFQQSRGQALEQNRSGSSVDAGASFACPRCTFSNHPSLLACEICGAPLLSQNTPSIKTESPTVRTESPGPVHEAPSNAPSGIDVADSIKISFRGGGMQIFYERLKGAITQRKWLLQNAPPVPKNGRSADPNTLAGSSDTSTSRTKTAGIAGLEQLGLNMHKNNEMLIGSAFEDLEALMSSAKEVIALAERYARQTNGVTGGASAEENAILAESASQLGLVTTKDIVAGGSSEYLYISELSRNLAEFLADDSRGVLKRAGGIITLVDLWAMFNRARGGVELVSPMDFEKAARLWESLKLPVRLRTFRSGVMVVQGHDRTDDATIKSLLSWLQDLHEFPPEREVTWDWREFGRGVTALETAERFGWSIGVAEEELLMAEEHGALCREEGLEGLKFWKNYIDTGDAPPPKSKARLEDEAIIKALQDSGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URF1</accession>
    <name>A0A7D5URF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g012450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549277.1">
        <property type="nucleotide sequence ID" value="XM_014693791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URF1"/>
    <dbReference type="GeneID" id="26238721"/>
    <dbReference type="KEGG" id="mbrn:26238721"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="270" mass="29966" checksum="8F7C5477F7E2B1CB" modified="2021-02-10" version="1">MGHEDAVYLAKLAEQAERYEEMVENMKIVASEDRDLTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNSSQVTLIKEYRQKIEAELAKICDDILDVLDQHLIPSAKSGESKVFYHKMKGDYHRYLAEFAIGDRRKDSADKSLEAYKAATEVAQTELPPTHPIRLGLALNFSVFYYEILNAPDQACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAETSGAAGQADAPAKEESGAAAEAPAATAEQTKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URJ9</accession>
    <name>A0A7D5URJ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC transporter atnG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">atnG</name>
        <name evidence="15" type="ORF">G6M90_00g022620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548292.1">
        <property type="nucleotide sequence ID" value="XM_014692806.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26237736"/>
    <dbReference type="KEGG" id="mbrn:26237736"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="162"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="497"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="801"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1100"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1347" mass="147232" checksum="9CD9B7514B946A03" modified="2021-02-10" version="1">MLTYLEHHRSVRPSSMLCVYLLFSSLFDSMHCRTLWLLHNAQPLATIVSALLATKVALLLLESQNKTSILSGKGESLGPEATSGIISRSLLWWLNDLFLTGYGTTLSVEKLHLLDLELRSETLLHRMHLNWPRYRDSGKHALLRTLLSSTKAALLAGVVPRICYSAFKMSQPFLINRVIRLVQNQGTEGAYSPEVGYALIPATVFLYLGLAIGYSFSQQKIYRMLTAIRVSLTSFLLDNATDLESGAKESSAVLTLVTTDVGVIERAFAQIHELWATPIELGLALWFLVVQMGWGSVGPAIAVLFSFIGTFQLSKFMAPAVKANNEATQNRISNTSSVLGSMKEIKMLGLVEPWLRAIVRLHDIQMKRSIFFRKLITLMNLLGNTPSRFAPVLTFGIALLSFGSKSGEKFTVAKAFTAMSILGLVTGPLSWLMFSLPTLISSFASFTRLQDFIMTCEDSRVRYSDAVIPGELNGPSPGTGSGAVAPFGFLGDAIIAAKDASIIFKTDDEAVLRDINLSIQPGSFTLVAGKVGSGKTVLLRGLLGQLQTKGYLKVYGAGAAYCAQTPWLMNATVRSNILGQSAMDNDWYKTVVSACALDRDLAQLPNGDMSLIGPNGLSLSGGQKQRISLARALYSRKPVVVIDDVLSGLDWITQRHVYNRVFAPKGLLRGSKTTVILATHALHLIDRPDSVILLGDKGPGQVIQGPLDELKASTGIQALISSSREESSAHEDEIAQKGTLLKTAQGPPRQKDVDGKIDSKIRTSGDISLYLYYFKAIGTRKLMILLISEAANALTNIFPEIWLMIWTTANLKNPKTSNGWYFGIYTLAEVVGLVLFGWSIWFVIINVTTSSVKKLHLALLKTVMNAPLSFFVSTDVGDLINRFSKDHDIINQRLPLGLWLSVSGVFSLLTSTAMVLYGSQYLAIALPLIVLVVYCIQAFYLRTSRQLRHLDLEATAPLYSHLKETIDGISTIQAYGWVPAFEETSLRLLDNSQKPHYFLLGAQCWLKLVLELFVGSLAVTLITLAVMAPGGTSAGAIALGLVNVISLSSALVELISHWTGLEGSLGAIERLKSFEANTPQEVTSPQPRQPPEKWPSRGLVEFDKVTASYSANSGNDHYRALNSVTLSIRQGEKVAVCGRTGSGKSTLLLTLFRLLDPDSGTITVDGIDISNIPQNVLRPRLIAVPQEPMLFPGTLRTNICPGGRTDEMEAGESDEHIISCLRKVELWDKISAKGGLDSDVSDLGLSQGQKQLLCLARALIRKDISAVLVLDEAMSAVDRETEELMVKVLEEEFAHHTVLSVVHRLNTVLKYDQVVVLDGGTVAEVGKPETLLQDQNGRFRALWDGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URM1</accession>
    <name>A0A7D5URM1_9HYPO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">G6M90_00g003370</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="90967408"/>
    <dbReference type="KEGG" id="mbrn:90967408"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="81" mass="9068" checksum="2C756890E1694706" modified="2021-02-10" version="1">MSAPVRAVATARFRKPLLGLMFGTSALGVATYVRSQLVTNSNTMDRFFATYNTPESEASRQKTFQGHPDPRTNILNFLSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URN0</accession>
    <name>A0A7D5URN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g017020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65235.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693343.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26238273"/>
    <dbReference type="KEGG" id="mbrn:26238273"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="392" mass="45242" checksum="CA0CB002C77ACFEE" modified="2021-02-10" version="1">MERLVTEDCAILIGGFNGSIFAGKGLGISDIGSHLIAKNIPDKTAWLGFDIHFPFGEDNEENGFGICYRWSDSEGIAVPTKTYTITVKFPGYNVVRDIWPADDSIRSRFPDEKRELYLVDVILKSGAQVIVEGYGMPYANRGHIADKWLHDNMPIIDNVTLTGLLAQRRYHFVVASENIRLSEDWNFDVLPRPFRYPYGRSHKWKSESEYYEMLEENKGRQFFPRTSFDDINELLTVLSQSQIQDIMWVQEDAEKMEGTKLPAYFVPANEDLKTWEDQLLYAIVALPPYFRTNFESSWRRLSREGKLKISVNDMTTSRCGTRPRDDPWDAVIVDTSSIKHIDVLEAHPIKAHELVLYIRRAPLRETCDSRFKISEFRDRSSADDAFENSKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URS8</accession>
    <name>A0A7D5URS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g017330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548797.1">
        <property type="nucleotide sequence ID" value="XM_014693311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URS8"/>
    <dbReference type="GeneID" id="26238241"/>
    <dbReference type="KEGG" id="mbrn:26238241"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="653" mass="71442" checksum="DAF8F27B869CE8D5" modified="2021-02-10" version="1">MADTPTPERIAAAGQGDSDEAPADGTSGSRPVPRGSAFYSRRRAVKACQVCRARRTKCDNRKPSCSFCLKVGAKCIQSPVDLSTFDPASLKILERLDDLERTMKTMTAGGAAGQTRLPPVAAKSTTATLIPPRPEHIVRWQVFGDLRQALEGVGLAEPEPAAPSHRQLSSLSSSPSSSTPVNDVTTELDLCRVNRLLDNFFNHVHVKNPILDEQAARHMVQSLVLNGIDWSAESCLTLLICALGFIGRPFGPTPDTMPGTSAYASAETLFLAAQRRIGSVFCSEDVVATQCLFLSGVYMMCVFQPAKAWRFFVQALASCQQLCLFLSSPAPPQSPPPAVCDTRPGGAGHSLETLQQATYWSSWKSEREMRGYIRPADFALSEEEMAFYPPFLPTPPNLQPAAQELESAGSNICLSRQTVSWYFYLAEISLRRLASNLHAEMRRLCEQTPSTQDTLEVLAAAVPQFEEQAEEWIASLPPCLSFDSPAEQDDVCRFVLRGHVINLFEMIYWPFLSAHLTRDPAPAPVPVPAGAAEARGILPWAGGGNIKRLAQRALDYHALRLAVNRSGYRHRHHGTLLMIESCSRSALVLVAAMLRNISSTARNSAKGADILPLPNGWRASLDETIDMLAFWESESRQSAGVRRVLQAARERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URV3</accession>
    <name>A0A7D5URV3_9HYPO</name>
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        <recommendedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">G6M90_00g023520</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF23">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G05900)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="271"/>
            <end position="437"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
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        </location>
    </feature>
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            <end position="69"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI65213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="450" mass="51026" checksum="BEAAE2B2BB7AF74A" modified="2021-02-10" version="1">MLYLSRITSLFDYGAIFLMVVTIIVFLVPILILFPPVPVDHSDALRQTHSKLGRPQRESHLRSQYDARHKPQAGKTPKIESLYIYPIKSCRGIELDRAKVLPTGLEHDRLYTFAQLKPKSTPAVTEPGAQTDSSSAWEFLTLRQLPLLANVKVDIWLPDAGKKSRLLGSLQGGFVAVRFPWQERGFLGLVQLLVAKLSRGWSAVPEKEFILPLEFPSKQEIDARGYKFANIKVWVDAPYALDMSNELPAELATYLGVKHSLGIFRSDPSARRKVFRTAPRNEMSGHEAEIDFHDAFPVHLLNLTSIRALESKIQKDRFIDRIDVRRFRGNIIVSGLKEYDEDDWKSVKFKHPGRSETMSRFDVSCRTVRCKLPNVDPATGIRHIVEPDRALRKYRDIDAGAPKMGCLGMQLLPTFPTSSNLERLESVLEVGMEVDVLERGSHLYVKQSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US35</accession>
    <name>A0A7D5US35_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26245911"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028913008" evidence="1">
        <location>
            <begin position="21"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7675" checksum="4A4DF802C47D37F7" modified="2021-02-10" version="1">MVRFAAVALALAATFMTVAASADAPQHGTVQHLEQRQEDAKQKEELSQLFLEYAKTADDIKNLMNKLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USY7</accession>
    <name>A0A7D5USY7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g016530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
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        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="19825" checksum="5197F33A43B5C6E4" modified="2021-02-10" version="1">MSDKKFLSAARFLAEAVHAAADDGKKKKKKNGDKTSQQTPGMSSDDIKELGSVALGVFKKIADTKPKNGDKNAQRAFSMSSDNMKEVAPVLIHAIAEYADGKAKKGDQTAKQGLGTSSDDATESISSPVAAATTPSRAGAKDGDKATERSGTKLIAKMLKESIKFAPKVVDILVEQQKKASQEASRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USZ8</accession>
    <name>A0A7D5USZ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Folliculin-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g022370</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
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            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USZ8"/>
    <dbReference type="GeneID" id="26237761"/>
    <dbReference type="KEGG" id="mbrn:26237761"/>
    <dbReference type="OrthoDB" id="5428015at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1191" mass="129865" checksum="90552F1B4E88AB37" modified="2021-02-10" version="1">MLGRLLHLGSGGPATPTVESSSNNASRPILSLESVQEDIHTRNLLFPDAQALYQHRNDQVFPLSTTPTTPGISTANAFDYSEDVDLDVKDVRVVVMQDALGPANASLLFDSHPPPDAMATSDRSPALQEARRDPISSRKGSLTQSARPLVIPSESPQPRQGAFDRRASIHSRSQSYHETESQRAAREYREELATFSSCIFGNSELMAYKGTSTKVHVVPSEARANESTTSSVFSDGKSSIGRSSGRSSKLSQSYSSQVVSPTIGASHPLGGVPPRQSDRRKVLITRLFPVSLAADDADHSVTPQNHNSDDNGGFPFPAQSDESSHKKKKPQPKQRRTPMYAVVLVVQIPKPSSRMSSAVPTKSVFRESGSYQDQELFSSSYNSAKAGWNMMSTSGMYGEAADSLDIEDRIDSLTRHWDIIMRTLTHLQSLVATTIHSMLKQADSTSPGPYSGSSGSNFVSRTPSMTERRGNELPRAKPPKSTTKLVSLLPNCLADDVNIASEVGLARSRIVMGLSAARVITGQGRWGIWRDEAIWTSKWAASTERTAFFYNLLTGFLATHTDWLQALCGPSYRKRATLARRNRNEEDLSLPARTIIISDDKMAARRLIFLLSAFLPANQQIPTARAHRPSASAPVGGYSNSPPTFIIPVLREESLRRKINRRSGLRRTSHSRTTSQSARNSGHVPQLAQIGLDRNHQRRASDAASIRTTNLPMLGTDLVTRKSSAATTTTIMPETTTPHFTSVQQRDCQRRSRPGSSGSVAADDLKRSLKRGEHSGQAGGVSRPPSSGLKWGNLINGLWSPRRRDSMDSGTYSQGSADLRSPIKTSFGRTDKLSEIVKESPEERFGAAIVDSAQEVDAPRDNYSGVRGRGSFAQADRTPDPTGAFESPVKTSINAEDGVIDVDVPFPEYITSFESAISSPSSSGYLSTPGLPSGLEAFEQTRFAIEGDLPLNAAGWLNRFHPDFALQALPPQDNLLDKVKAALRAEPSPAPTTQSNDLSERWVDVSSVMIADATNNSVSRIVYRRLVKPKAQHDPPSGNLGAGGYTMHTPSILPYETQLEEEWIEEPIFTCDEALRDAVERAIHFNSDASKGSSTTSSSQTPSDFQGSMESDSTMPDTLSEVTQLANPPLDAPRVQCKTVILSALEDMFREAVDSRDTGHTGRANNRLNRHRHSILYDAVRAWVASMDAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTK6</accession>
    <name>A0A7D5UTK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tuberous sclerosis 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tsc1</name>
        <name evidence="3" type="ORF">G6M90_00g006780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549831.1">
        <property type="nucleotide sequence ID" value="XM_014694345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTK6"/>
    <dbReference type="GeneID" id="26239275"/>
    <dbReference type="KEGG" id="mbrn:26239275"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="647"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1001" mass="111271" checksum="C60BDE3255B0E1AA" modified="2021-02-10" version="1">MASTTSLKELVKTINTFLVDPSLPLPDTFVDTLTTFTQKQEEDDNSAADLLQDSLLSVFDKRVKGNAKAVGPWIAILRRLLPVLQTPERILPWFDACKGILDRADLDKYVVDETVASLMDLITLIDEFQISFAANSAANRIIDRLFQVWMDRFYPALLDGNTSSEYNERLIRHALCNFGKKRPKELFTAMDGYFVQSKYRKSALRFLCDFIQIQPPHLHQVLHTSLFGNLMTCLQHDTSTTIVSAALTTLIMLLPHMPSSLVPHLPALFNIYGRLLFWDREHSRPAEWPDSDGAGPEPAPGWEVATFDPDVDDQSIAHLPNYYTILYGLYPINFMDYIRKPQRYLRHANAANADEVEVQPTEMRHRSETFRRNHLLHPNFYSLTIDSEKTDFGRWIKSEAAEVVAECMGLCLETDLYNFADLSSAEIPGSSPGVVNTTAALGNDVLEKSKADAALLSGPGGKHDSWRNSHLTASDSASSNQTPVTAMRRGSQSSVPSHRDSTGDGRSRTGGTDSPTLTLSPSHPQLQDLIQSNKVIKSGLHQSLANDSVASLALSHQDSVTEKAPPGAPTASAATAPLPLTSHSPFPTSEMSTQVVHLQKQILLLQNDLSFERYLKQQHMAHIGDLRRKQMAEAATEAETQNLIMMNRNLKSRFEDAKNSEMQVKKESEKSRAMAKKWEADLANKLKDLRHKSKKMQAEMEALQRELEESKQEGDKLRKLLCAAEVKELNWKQNMQSIEIHGAEIDRLKAEVERLTRSERDHQAKELERQQMINSATKTESRAEALKMRLDAQENEVQRVKKLFQSQVAALQTQLSEAQEERERPGSNSNLAVESALAASRAKQAELQKQHALLMRKYTALQSSLLDMQSEQPPEQTRATASQHQPTDADYLSLSTSPVVVKARSHRALSNAEATGHNMKSAGGSQSGGTTTGSTLTKEGSGSQAEASGSPISPDQRTFSGLQSRLRRDSRDKSKDDGSSASGKPKKEKKSSGLRGIRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU77</accession>
    <name>A0A7D5UU77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ISCA2</name>
        <name evidence="3" type="ORF">G6M90_00g035420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546937.1">
        <property type="nucleotide sequence ID" value="XM_014691451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU77"/>
    <dbReference type="GeneID" id="26239500"/>
    <dbReference type="KEGG" id="mbrn:26239500"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="108"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="240" mass="26042" checksum="50E9045250F57412" modified="2021-02-10" version="1">MASVGCANGASAARSFIQIAKRGYSTAAARSSAPLEFLLPRTASTTHCHAAFLLRSTKTTRTGRASLRGAPFSGGLRQSQKRTFTTTVSRQATVCVLNPQKDEDGNEMMLEITPRAAKRLSQIMKKDDNPNLALRIQVESGGCHGFQYLMSLVTIPPKDTAEWSTVVNEDDTIFQFSDEADTTSSSEHGPRIIMDEPSLDLLKGSKVDFTMELIGSQFKIVDNPYATSSCGCGTSFDIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUC5</accession>
    <name>A0A7D5UUC5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g032480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986320.1">
        <property type="nucleotide sequence ID" value="XM_066130110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUC5"/>
    <dbReference type="GeneID" id="26243981"/>
    <dbReference type="KEGG" id="mbrn:26243981"/>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="165" mass="17575" checksum="4BB4CDECDF61CA2A" modified="2021-02-10" version="1">MSESGYSWKKKNNVRLPVNAEKVIAVQPVVMKYGSKTIPGHAVLHVVQGKKAIVFMSIDAPHDIDIQPQPTPDGFSDLLAGGTGLFRFKAKELAHPGPSKVTDAGVFSSVKDLQVTTSGSGTSVWASNTNNGIGYIMTDTHFGVPDPVAVQVVPDHQGGYFAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUE6</accession>
    <name>A0A7D5UUE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g046510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544777.1">
        <property type="nucleotide sequence ID" value="XM_014689291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUE6"/>
    <dbReference type="GeneID" id="26242118"/>
    <dbReference type="KEGG" id="mbrn:26242118"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="577" mass="63161" checksum="9F322E91D3AB2CA7" modified="2021-02-10" version="1">MSVLTETCWNYPAGSATLSGNAVAFTPISFPASPSSTSPPAASPPPPTSLSTTLTGVPYPPINRIRNRRNSSRMPSTSSSLPNPKDLSIEDDWTRVKDPKEKKRIQNRVAQRTYRHRMKARLGELQARLDSHERQRIHAVSHGGNEMAHGVTGVPLGYNPNALTTNSHSNVNSLASLNSILAPSHGGETSQSPLGNDQHPPAIPMLQTNIYDQIAEESDPSLFSHNTQFLSSPPNSHTSPQNQNGLPSPPGRPDLEKPNKVSQDFVLDCLHFQTRLLNRLNTLEQDSGCSSQGTYSQTDGLSHYGMSQDQIACMRTFTPTQTESVEFAFESANDGWKADGFPHKLRQPSSTGSISYSPMLEAPAPGVETEIGQNTHHGTGTPQAPTGSGPIPARNAATDERVESIIRHLQSIGFESFDDLAAAYYSRTFSDLSPMTAGQHISRDRRLAKVILNVLQAADNWTHWERRGFHEEILRVAESVVTPEISATGDSLVSQIRSLIETLDFQDLSKAESLESMRDLIQHEMPNSWSLNMTLASGKGSMRHNNPSNIALATTLLQKFAGRLPKHELMQFVEACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUI9</accession>
    <name>A0A7D5UUI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g028360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541326.1">
        <property type="nucleotide sequence ID" value="XM_014685840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUI9"/>
    <dbReference type="GeneID" id="26245961"/>
    <dbReference type="KEGG" id="mbrn:26245961"/>
    <dbReference type="OrthoDB" id="4937432at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="202" mass="24400" checksum="9C81BD97EA82B314" modified="2021-02-10" version="1">MATFHPFPRLPYELRAKVWALAAEPREVPIRAKYEHDDRFEEILYLISPTPVPAVLHTCRESRKESQYEKMFYFQETEPRYVWVNFDLDMLAVGRAFLDHVVHNKSRVRRFKFEYEYEDDEWDFEDYEESWFPNLVECHVVVGDMSGCTRFWNEDYWLSKQEDFVFIDKKTGKRMNVCELGDMVERLLVQRLGLIGMMAIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUT8</accession>
    <name>A0A7D5UUT8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g050100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545118.1">
        <property type="nucleotide sequence ID" value="XM_014689632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUT8"/>
    <dbReference type="GeneID" id="26242459"/>
    <dbReference type="KEGG" id="mbrn:26242459"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="399" mass="43316" checksum="B27BEEA727E12116" modified="2021-02-10" version="1">MPRDPHTLLKQAEKKLSGGDGFWGFLSDKSGNDSDGADLLEKAANAFLAENSFVEAGKAFEKLAAVYRDKLELDSSAAGAAGSAIEAYVKAGDAPAAARCFELLRSPALKKGQSNRVDRYGRLLAGLYEKTLGDMKSASLCYDAIAEEYESNHNPHNARKNRIQAAATRAIYFAQLVTAGTNPHESAKDLKYVERNFMKLAQDSYNTNEMLFRLGVVYLITGDSNDYDKAAAPAAPAAASVAAQATAAGSAAGPLAEEANAALDAQTRLDYGFTRSREGALVRDLAAALKADNLPQFVKFVMQYPGTNEESKAWNETMLMLAGGYKWKGNAVKAEIERQKRQPFEDSQNEGQQQSLGSQPPPQQYSQPQYQSREHAQYPPEKQGANDLEPDVPDANEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUZ3</accession>
    <name>A0A7D5UUZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RER2</name>
        <name evidence="5" type="ORF">G6M90_00g051410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986389.1">
        <property type="nucleotide sequence ID" value="XM_066130509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUZ3"/>
    <dbReference type="GeneID" id="26247381"/>
    <dbReference type="KEGG" id="mbrn:26247381"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
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    </dbReference>
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        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
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    </dbReference>
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        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
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    </dbReference>
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    </dbReference>
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            <end position="282"/>
        </location>
    </feature>
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            <begin position="222"/>
            <end position="242"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67490.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029018268" evidence="1">
        <location>
            <begin position="16"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="202" mass="22477" checksum="14A5F344FB397D77" modified="2021-02-10" version="1">MKQAIFLSIVSLACALPQSTPVTGQKLLPWKQPATLTGSIDCGFKVSDEEQCGTELYCNLFDNQKPNSNYKSAFQCFQSHEAEPKLLPWKHAATLLGFMECGFKGGDEEQCGTERYCNLFDTQKSSDYKSAFQCFKAHEEKPNLLPWKQPATLLGAKDCGFKGADEEQCGTGLYCDLFDNQKPNSDYQSAFQCLQAHEPSPV</sequence>
</entry>
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    <name>A0A7D5UVF3_9HYPO</name>
    <protein>
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        </submittedName>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="QLI67858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="369" mass="42824" checksum="A0E66109FD30AAD3" modified="2021-02-10" version="1">MASFRDVREDHANESHDQLRDKVLTFWPNGKHDLGASTSGINCLIVLLKRIYVSMNEPLWNKHDESVKQMEDDNPFMAHAWLLLGLSLNTIGVALDNLTVQVWGKKLDNVAPEDLHFKNLVSHARMQTTLWSMPQFNLMLDHLWWQQDTRRWRRLQHKATPTEVKDYFAKWHPTPTPDSVRLDAFPGMSLDVEVNKLFGEFSVGEFTVLVRPDAPSFFYATFTVKDVGQEKLDFNAFRRFTLEVGKSVDVDGVMRWQRTGRPGQMPYNLMAIVKYRDTADGSDLIRVYDDFGNNSIPVGKLPDYASPEWRMADMKNGDTFLALFVYSRMPPKSRPPFPEVYKNVDKTEFCEQSRFFSKFSAGRRVRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVR5</accession>
    <name>A0A7D5UVR5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">G6M90_00g050890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVR5"/>
    <dbReference type="GeneID" id="26242530"/>
    <dbReference type="KEGG" id="mbrn:26242530"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
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        <location>
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            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
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        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="363" mass="40335" checksum="7849D8D9E09845CD" modified="2021-02-10" version="1">MSVDAGRGLPATDTSYSSDWLLIIVFISIALYNVVELNFLIATTFKRFRGLYFWSFTCSTWGIAFNAVGYLLRHVHPNQLGYLHATLILVGWCAMINGQSLVLYSRLHIVMHHPRRLRFVLAMIIFDAVWLSVPVIVLVYGTNSGDPGPFEQPYSIFEKLQLSVFFVQEVIISSLYIVETTRLLKMQRGIASSSMRRVMGHLILVNVFVVLLDVSILCLEFTEHYNLQTAWKALVYSVKLKCEFSVLNRLVEFSQHLRAGHDVSSVNYDASTDVALERYLRNASQAPAGAEYSMQVTAERPCENGPPEIVKTTAVTVSRSGRSAPPTRPSTAADSSLGGCAADEMHDADGTSSLSSEARLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVY1</accession>
    <name>A0A7D5UVY1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g035970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546992.1">
        <property type="nucleotide sequence ID" value="XM_014691506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVY1"/>
    <dbReference type="GeneID" id="26239555"/>
    <dbReference type="KEGG" id="mbrn:26239555"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="40565" checksum="9C6609AD081EAF33" modified="2021-02-10" version="1">MSSPTPSNLAVTTTDHAGLIVIAAVVGATWTVMVYLIRLYIRLSVNGPFGIDDGAASFATVFGLVQTAITLLAVRNGLGKQESLLVADEVDRALKLNYASNLVYIVAICGSKCAMFLLIARLGQDRRHLLTTYGITLFAILWAVVSLFLMAFQCSLPEPWNVHIASQCPTLVTRWVVVETFSTFLEFAISALAVALVWGLSMKLKTKVMVVCAFSAQLLVIIPIAFRLHFVRVSMYGSDATFNSTEITIATQVVMHFSIMAATFPCFRQFLQAFDSGLGATTKISTENGSGSRSQGGSYVMQSLVSAREDGRVGKARARLRPDPTAEIVTAVAARSSDHGAEDMSIDSSGSDKAIWTRREWEVHYESRERRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW02</accession>
    <name>A0A7D5UW02_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g045970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544724.1">
        <property type="nucleotide sequence ID" value="XM_014689238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW02"/>
    <dbReference type="GeneID" id="26242065"/>
    <dbReference type="KEGG" id="mbrn:26242065"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="925"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128617" checksum="C096220B0286F54A" modified="2021-02-10" version="1">MPPRPVRRRPTRFSVREPETPSNANPLTFQKPNLPPLQGTPSSRRQYSYGAEVEPMPSRPGHGLSRSQARDIGSAVRNVLTAPGVNDEDEEQDEDEREQTQKPQKPKNAQPEPDELAGGQLSRPPHLPSYLSGPSNTALATRSLLSLRNARPDGSDGDDARSFGIESEFYGDATIISTPRALPPQRPELRDELSGDSVSTNETPSRSTMNKPPAIIGENEEVDLVRQPQNAYKGPAKSTVGPSPLRAPPRRPPQQSARQPRFEQQEEEEEEEEEEEEEEEEEEHEDEEEENELDTNATDKEREGSEEDDLIRRQEPRPILQTNTPVPGRSQPAPRENVQRTRIGGPSPAPPHPRPIPRLLPPNTTRGTLGPTESTGPDKMRRTQLLTGAPLEPRQRSNREHRGPNFEENSSEDGRWLDRATATTTSLFAQAKFLVNSSPFGLGRRYPTDESERDAAIQRDITEAEAEVARERLREEEEAAYQRSYQRWLWLKSLVPFIGREQTHTELDGAAARANNRWSTFALIRFLNPMTYVRAIGWLIHAVLDWIMELVYFIIPAGVWDQLSSVFGFLPHILAGALAFVAAFALATQLAGSTDSSWAPNAIEATLRTFDDLRYRISDLIPTVTWPKRDRWVDLDDLWEDDDSSRDKLQHFLNRMEEEFLTLKRSGKIHDASLRKLENILPSVVHMELKDGRPVISEEFWHALRDLIHGDGGFLAFDKVGSEYVVSSDRQWSAITSRLLRDPAFTTKLNLTALGLEDRLSRKMATFWDKWVKDNDDKIAHLLGTAVDQIKSAGSQREFEDRLNKIVSEQLSQREEKEGQTGKFVSREEFLRHLRNEIASLSSQLRAELDDLRPQMESLVQQTVDLATKDLTHSMSRADITALVNNLIGKALADVNLEAMALGKIHNHWETELRNQVNYFAVGSGAKVDPRLTSATWDPQGAAIAPHQYKHGWRGSEAFPPIAALEPWQEEGDCWCAARSVNHRGNPHGATLSVQLHHSIIPQHIVVEHILPGATTQPGARPKSIEVWAEILDPEARERILDFGSVYLPDDKNDWNYTPPDFPAQFAKIAQFVYEGTELHEGVHVHRLNSELLALGAHTDRVIVRAVSNHGAENHTCFYRVRLYGFNVELDRDEGGNSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW67</accession>
    <name>A0A7D5UW67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD/NADP-dependent indole-3-acetaldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">I3ACR</name>
        <name evidence="8" type="ORF">G6M90_00g049320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986462.1">
        <property type="nucleotide sequence ID" value="XM_066130466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW67"/>
    <dbReference type="GeneID" id="26242382"/>
    <dbReference type="KEGG" id="mbrn:26242382"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="301" mass="33011" checksum="E1F179BA155B889D" modified="2021-02-10" version="1">MASSDTASKGSFPPTLKLNDGNEIPVLAYGLGTANYKSTSGYDQSVVAITKTAIDLGYHHLDGAEVYGNEEELGAAIKASGVPRSQLFVTTKAHGEQQKPTQEAFELSLQKLGLDHVDLYLLHGPWFAASHEELQQKWADLEAIKASGKAKSIGVSNFLQEHVEVILQTAKVVPAINQIEYHPYLQHGDLVAFHKKHNIAVSCYGPLLPLTRAKGGPIDAVWSELAGKYGVSESEIGLRWILDQGLVALTTSSNKGRLQDYLAKLGTFELTQEEVARIAEVGNRYHFRGFWLNKFGPDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWL0</accession>
    <name>A0A7D5UWL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1993 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g044760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547808.1">
        <property type="nucleotide sequence ID" value="XM_014692322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWL0"/>
    <dbReference type="GeneID" id="26240371"/>
    <dbReference type="KEGG" id="mbrn:26240371"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18902" checksum="FA17B4126BE36358" modified="2021-02-10" version="1">MSYTLYDGSIATAQDNLTSLKAILKKAETAPNAASLPDARIHEDMLPLSFQVHVVSDIAQKMVARSTGAEPQKLENDLKTFDDFYKRIDQVQELLTKTDKEVVNKRVGDLVPIGLGPGKDAELPSHAYVTGYAIPNLFFHLVTAYNILRKEGVPLGKMDYLTPFIGKHVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWM5</accession>
    <name>A0A7D5UWM5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prosolanapyrone synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sol1_1</name>
        <name evidence="4" type="ORF">G6M90_00g052110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539405.1">
        <property type="nucleotide sequence ID" value="XM_014683919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWM5"/>
    <dbReference type="GeneID" id="26247805"/>
    <dbReference type="KEGG" id="mbrn:26247805"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="2"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="203" mass="22005" checksum="8E593E2B03559951" modified="2021-02-10" version="1">MGKYARSPAGAIAQVPDGKSLIHAASMLLSYTTSIYALHHLGRLRKGETVLIQSASGGLGIAAIYIAQYLGADIFATAGTEKNREMLVEEFGLSPTHVFGSRDAAAVKRVMQATKPNGIDVILGSALGGDSLQEQWTCIAPQVRFINVSRFNALESSILALDVFKRNATFSSFDIDLLYRQTLSLIARYSSPLFSDRHVKVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX57</accession>
    <name>A0A7D5UX57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">hxA</name>
        <name evidence="23" type="ORF">G6M90_00g033450</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543273.1">
        <property type="nucleotide sequence ID" value="XM_014687787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244074"/>
    <dbReference type="KEGG" id="mbrn:26244074"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="26"/>
            <end position="112"/>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXY1</accession>
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        <recommendedName>
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        <name type="scientific">Metarhizium brunneum</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">4556</strain>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
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    </evidence>
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    </evidence>
    <sequence length="814" mass="93978" checksum="17CD9899EFACE83D" modified="2021-02-10" version="1">MSLAVEDDRRRDRSRSRSRDRRPRDDPEPSSATRFADVREPSYVYPEDDLDDRYRSRGHRDSAHAGGLPYPPEGGMDAMLPGSQSLYSYDDARPIYKTASPPRESSHRSSRDKTERESSSQLPGSFPDDDRSRRDHDKERHVRYADPRDSKYERMNRSDDDYHDPRARRSHKYAREDEGPGIRDASPPRDKYSRGSRDDVSDDKLKFLPQKYSRRYDDDDDTNGNRDDKYSKRDKDRRSDRDSRSKKERDEDDLAYGKPPGPSRSRRQESPPTYGSYISASQVSDKRSSRYGREDDDDRRQRPASPSENPYDARKSRREPSYRDEPRHSANVLTVGPGSGDRDRSRDRRRDKSPGPATLSPESDRKERDRSRDRRGGARDKSPQPPTNRMSSLTVDTGRSSNLSLAAAPASPLLESYKGTYQDCSPMPSPLLIASKDPNSDPRVIEALSPLNSDVDSPDGKKRSRRARFHDPEDIATRLARALKGDRTPDIRPLIEILPSLTHDQVMELRSQYKRIVKTGSDRKGVNIAKHIRARLKDEDPNLMKACYAVALGKWESEAYWANFWYQGDKTRRELLIESLMGRTNDEIRHIKDAFTDKKYDNSLTKCMKVELKEDKFKKAVLMVLDERRMDDFDPYGRRMPIDYHLVDQDVDDLRRAVKAEKGGESAMISIVVKRSDAHLRHVLQEYEHHYRANFAREALKKSGNLVVRTPTIPEGELLAHILNGVINRPVRDALLLNHALTASRKDGLRRELLISRLVRFHWDPAHMQAVKRSYRERYGVDLQEAVREGTSGQWGEFCRELCIARMPDDVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYN0</accession>
    <name>A0A7D5UYN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542649.1">
        <property type="nucleotide sequence ID" value="XM_014687163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYN0"/>
    <dbReference type="GeneID" id="26244598"/>
    <dbReference type="KEGG" id="mbrn:26244598"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="98" mass="11167" checksum="ABEC14572F541DEA" modified="2021-02-10" version="1">MAAKGQTVQRKHQMVQDYTSEPEEEVPRQIALQQQPQLQAQQPQIRAVAQTSEKSNPLKLRLDLNLDVDIQLRAKIHGDVTLALLWVVASRRPATQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYR3</accession>
    <name>A0A7D5UYR3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">rmt3</name>
        <name evidence="20" type="ORF">G6M90_00g072900</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545772.1">
        <property type="nucleotide sequence ID" value="XM_014690286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYR3"/>
    <dbReference type="GeneID" id="26241805"/>
    <dbReference type="KEGG" id="mbrn:26241805"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000034">
        <property type="entry name" value="Protein arginine N-methyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF116">
        <property type="entry name" value="PROTEIN METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="20" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 15 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="18">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="17">
        <location>
            <begin position="237"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="19">
        <location>
            <begin position="340"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="535" mass="60539" checksum="FF5F6241B4D8059E" modified="2021-02-10" version="1">MDKLRAASPSSGSDTSEQSNWLDVEPDLENFEFVSLFDVQAFTTLAEMLQHCKQQHNFDLVQNIHRLQLDFLGALKLVNYIRSQVKSDIALPSQISLDDIQDDRFLKPVLDNDAVIFSLDEVLQPSSDTEVETAGTLDESSRDLHRKNRDLQSELNSIRESFANYRLAVEQTLDRRWGVDEIPSSSANLKEKDSSGYYFESYAAHEIHETMLKDAVRTDAYRDFIYENKHLFKDKVVLDIGCGTGILSMFCAKAGAAKVLAVDRSDIIDKARENVFNNNLADIITCLRGSIEDVQLPVKEVDIIVSEWMGYCLLYEAMLPSVLYARDKYLKPDGLLVPSSATLWISPVKDEAYMSDHVSYWRDVYGFDMKAMQEGIYDEVRVQGMPASSLCGRAYPFKVLDLYSTCAEDLAFTTNWETELNVGTDDPDGFLIWFDNFFSPCRSEPIPEPRITPDKWVLASPGHVAFTTGPNGPETHWKQGLLLTGPRDPSQTISTSRHLSGEITFAAASDNARALTLRLRWSTEHEERSQSWELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYW7</accession>
    <name>A0A7D5UYW7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Pks2_1</name>
        <name evidence="10" type="ORF">G6M90_00g069690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540705.1">
        <property type="nucleotide sequence ID" value="XM_014685219.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26246578"/>
    <dbReference type="KEGG" id="mbrn:26246578"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.110:FF:000001">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF45">
        <property type="entry name" value="CONIDIAL PIGMENT POLYKETIDE SYNTHASE ALB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="383"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1671"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1784"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1316"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1473"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2184" mass="237711" checksum="0AAAA4D5BCCC7A14" modified="2021-02-10" version="1">MMTNTTDIPQKDPELIAFGDLAASECLDSLQGLLHSKNNANLSDFFVRVSFGLRQFLGCLPSTQQHLFPRFSTLVDLLDKWECAPGRPALQLFLLSVLQSAQFIHHYGGNAATEYPSAADTCIISSCAGNFTAAAAGCSSSVTSFVPLAVESALAAFRTGLKSCLVGETIAVERSDASMTWSASVLPTTNATVEELLASFTKSATVLEDYEAIWVTARTPTEVTTLGGRPLVLSDFVAVNKDKLRVKWLDIASPYHAPHLFSERDIDEIMEGVAENTATSAASRIALLPAYSSADAKTDFLGRLRMAVDGALRRQLDLDAVFRSCGEHLSQMGSRRCRLTAIAYGTTSMLSTALLNNFGIHLDMTDVLQVTSDTSHVPGRFEQSKIAIIGYSGRFPSADSTEAFWELLRAGRDVHREIPDDRFDHKTHYDAEGRATNKFRVKHGCFVNSPGLFDARFFNMSPREAENTDPAQRLAILTTYEAMEMAGFVRNRTPSTQDDRVGVFFGSTSDDWRDINASQNVDTYFIPGGNRAFCPGRISYFFRLSGPSLSVDTACSSSFAALQIACSYLLSGQCDTAIAGGSNIMTNPNIFCGLDRAHFLSTTGNCNVFDDAANGYCRADAVTSVILKRLEDAEADNDPILGVIVAAGTNHCGHAESITRPHEGDQAALFQQILRRANYDPLDVGVVEMHGTGTQVGDATEMSSVLSTFAPRAERSETQRNRPLYVGSLKANVGHAEAASGITSLIKILLMLKHNEIPPHCGIKTQINRSYPADLAARGVYIAAQPTAWPRYPSSTKRAAFVNNFSAAGGNTAVLVEEAPRRSGNVQEMDGRQTHLVAVTAKTAPSLLNNAQSLASWLQHHPDTALSELSYTTTARRTHHEHRIMVSAENVPSLIRDLASLSNQDPKTVKPIPPPGKRPRIVFTFTGQGSLYIGMGRDLFNVYRSFRQDVTQLDQLAESYSFPSFISLINGSTSAEIHTLSAVTSHLALLCTQLALVKLLHRWRIQPTAVIGHSLGEYAALYAAGVISAGDAIYLVGKRASLLDQHCRKGTHGMLVVKASRRETERLLRVVGTDFEVACANHPGAHVVAGPKDQMPAVIIAAHGAGLATVELDVPFAFHSSQVDPILPGFEAAAQAGVVFRAPKVPFISPLLGRVVADGEDGVLNVSYLARASRCLVDFSTALTVAQGHGLSGNGVIWLEVGARPLCASMIKQTLGAGERVLNTLRENLGGCQTMAKAVEALYLAGMDVDWSEYHREFPAAHVVLDLPRYAWDLKNYWIDYKDDFCVNRKICLGKTQDAELQTRVETFKYISPVAQKVIEETHTQTKSCMVVESDIFHRELLPVLRGHAINGSFLCPSSLYAEIALTLGEYLVQERKLCRESTGLEIFNLRIDQPLIAKDDETSRIFRVTTEADWSSNMLSLAISSVSPSGEQPVSHATVHVRIVPNQRWLADWKRNSHLVMSRVQALERSNNSQKLRRRMVYKLFAAVVDYSDDFKGMSQVLLDTDALEAVSTVQFQIESREGRLGMDARWIDSLGHISGFIMNANDATNSQEQVFINHGWEKLRHAEKLTASKTYRAYCRMQLEEKTTFVGDVFVLDGDRIVAVYEGIKFVGMQRRVLNHLLPAKRLVRGQEPAATGAVRHDSGLCYSGSNTKKSVSHEVASAIGNQPSVTASGFGPVMEIICQEIGIPPCDLDPESQLADLGIDSLLSLTITSRVRQELGLSISSAELLACGLVGQVQHLCEGSFVYSSSTDDNSSNGSEVTSAYESVVSATSEVCMSETSDGDSIRSVLWETIARETATPVDELLPSTSTADAGIDSLLAIIIAGTLCEKLSVKITGATILGCETLLDLEVALRKILCNLPSPGSAGAIKTGFPSAPTTQVLDAVPKSISAENPHGSILSRDSAADSVLLSGSVSTAKSVLVLFPDGSGSAASYANLAPMFSKDVAVYGVNCPWRKNGLELIRKKITVSQIVARQLVEVRRLLETHKQHGWQNHPTGTPNLVFGGWSAGGVLAYEAIRQLADEGVPVRKLLLLDSPDPFGLQIPSRKMSYFLKDVLRFGGRTGKAPDWLLQHFDGMVEVLGTYSPLPLASSTDLDTLLVYARKGANNDYEGQERELHAPGNRDICWILRDRTDFTANGWKRLVGSERIGIEILDLADHFTMMDDVHQLKQLGNIVNGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ93</accession>
    <name>A0A7D5UZ93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gas1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g074850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986943.1">
        <property type="nucleotide sequence ID" value="XM_066131017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ93"/>
    <dbReference type="GeneID" id="90967956"/>
    <dbReference type="KEGG" id="mbrn:90967956"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028801278" description="Gas1-like protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="52088" checksum="DA7EB927EC3431BB" modified="2021-02-10" version="1">MAYHLSLRRLLALSALCSLGSAHSKIQKASCDGGKTSSIGMGTNPNIPIDGEDPTPFQLDSPIIRTKEKDNLLVNGCGRTKLQTNIDVANETEIAIQNNQIANCKPGDTLTMTVFVVNTDGSGPYFADIDEKSNVGIFRELGKVDGIDGKNGIQRNAFTAFDVQIPLPTDMKCEGGKDLNACTLRIRNLADAGPFGGCVALQDVTKGGAGNGGAGNGGAGNGGAGNGGAGNGGVGNGGNGGNGGLGNGDQGNNDLGDGGLGGNGGQGNKGQGNKGQGNKGQGNKGQGNGGLGNGDQGNNDLGDGGLGGNGGQGNKGQGNKGQGNKGQGNAKNPINRRGMRIKRAENAKQGGKGGDGSKNTGTGNRKPGNGNQNTGAGGNQNTGAGGNQNTGAGGNQNTGAGGNQNTGAGGNQNTGAGGNQNTGTGGNQNSNNGGVRSPDDITTADTLDIILKEQQISLKSLEDFLKNGGKNQGGNPQNGQNNAGNGQTGGNQTGGNQTGGTQTGGTQTGGTQTGGNQIGGNQKGGKQKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZK8</accession>
    <name>A0A7D5UZK8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin POM33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POM33</name>
        <name evidence="7" type="ORF">G6M90_00g071000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545957.1">
        <property type="nucleotide sequence ID" value="XM_014690471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZK8"/>
    <dbReference type="GeneID" id="26241990"/>
    <dbReference type="KEGG" id="mbrn:26241990"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PER33/POM33_regulator"/>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
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        <location>
            <begin position="25"/>
            <end position="45"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="31470" checksum="A7E07E12AA2EA41E" modified="2021-02-10" version="1">MAPPPPNSSQPLQERLLQLAKTLQFAWFVGHMTLILTTIRYGFSWLRMNYYGGMAKFSYRTSFLAAAVTYGIVVYKTQRARAKTGNKMPGGAIGLLSDENIQYLLMALVWLFSPQYPLALLPYCVYSIFHVATYTRANLIPVLQPPPPTADGASPQRVSNPLADRIGAFVKEYYDASMSVVSGLEILLWGRILLSAILFQRRSWILITLYTAFLRARFSQSTHVQHSMSQLVARIDSLVGAQGTPPAARQVWDNVKNVGRQFRDATDVSKYTQGPAPAKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZQ7</accession>
    <name>A0A7D5UZQ7_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">GTP-binding protein RHO2</fullName>
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        <name evidence="3" type="primary">RHO2</name>
        <name evidence="3" type="ORF">G6M90_00g072060</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="235" mass="26344" checksum="D29E9A8BDC6317DF" modified="2021-02-10" version="1">MAAKPTTKPHFGPGISFWQPPLHTKTIGCFFSRTLPELIRPLRSTQGTMDPETVRLLLVGDEKCGKTTFLSRLSAGEGTSPIPILRDIDQPFVFNINLGEKKFRLEFSDTSSPDNWRLLDPDVIVICYDISQRLSLINMKRYWIDEAKRTFKRVDTLPIIILGLKRDLRSENDPNGIIYPQEAYQLAQTMRADRYVECSAATGELLKPAFEDICKTATKTTTAAGGQSEGGCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZS7</accession>
    <name>A0A7D5UZS7_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">Cell wall mannoprotein 1</fullName>
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        <name evidence="2" type="ORF">G6M90_00g078330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70857.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
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            <begin position="18"/>
            <end position="35"/>
        </location>
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            <end position="76"/>
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    </feature>
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        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29705" checksum="16254CA5394F0E99" modified="2021-02-10" version="1">MRPKPLSTTRRRYHHSLDPSSANTTEPTDSSSQGDANDRVSPPTTFASKLQIPQEGHYIKPPGRPSQQKVNSNNIIPKSHLPSHHAHKKHPPPPKATMKFAALALLALSGTHAAILPRAGDHDLPKCLNDVTGSITKLDAETKAFEGTIQPVVNATDAVTANIQTCQAIVDNSDPIGLAGALVLLKPVQEMDKSAKRLLDAVKEKVDAVKKAKKCGLAREKIGALCTAGRALTQSICNKISHSMARNIAKRHAAKIENLLTQSQELFEQGKCDDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZY7</accession>
    <name>A0A7D5UZY7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g075860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690028.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241547"/>
    <dbReference type="KEGG" id="mbrn:26241547"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7962" evidence="3">
        <location>
            <begin position="112"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37409" checksum="E2D13CBE46BF0C04" modified="2021-02-10" version="1">MASENIILYHYSYSPYARRVTWYLTLRGIPYAQCVQPPTMPRPDVARLGIGYRRIPILSIGRDVYLDTRLQFIKLENMDISLPRLGTSQPDQRAIERLLSTLMTDAGVFGWAASLLPSDLPLLKNPTFQKDRAEFFGTQPRPDPKHVALREVASVFNLLETTLLADGRDWILKTPGPGLADIEAVWPLHWLAGLPGALPKDRFGPQVYPKVYAWIQRFEEALQQARKKAGKPRTVSGEEAEKLILASEYHESEGPVDEGDFEVAKLGLRKGDEITVGPTDFGATRKDVGRLVSLAGDEVVYETKPEGEGKQEVRVHAPRHGFRIQKGREAGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V010</accession>
    <name>A0A7D5V010_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PNAA</name>
        <name evidence="3" type="ORF">G6M90_00g075760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545523.2">
        <property type="nucleotide sequence ID" value="XM_014690037.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V010"/>
    <dbReference type="GeneID" id="26241556"/>
    <dbReference type="KEGG" id="mbrn:26241556"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028933479" evidence="1">
        <location>
            <begin position="17"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="83"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="669" mass="73718" checksum="18300A7E94978C60" modified="2021-02-10" version="1">MRHLLWLAPLVVQALAMASATLRGGRDVMDAPNQKGLLDSRAAAGYPDEPLQCFEVTNPVLSSDGIVDGNEILDSYPGSVPPKACKIQLMDHVFGNSYGQPFVSDYTPPDETKCPFNRVIMNFTVVSEGHQFDRLAIMWLGDTEVWRTSTAEPNAHPGISWTYWKDMTTYLSILKRPQKLIFDLGNLINSNYTGSFNTTLTATFIQDQNLTGPAAPPADEIVPFSAGNGASGKGSAFTYPDEKAEKSITLPRNIKRAVLSIAATGQSDEEFWWTNVPEDAINNWEGMTLLGKSSFREVRLRIDGQLAGLSWPYPVVFTGGVSPPLHRPVVGPQAFDLREQEIDITPWLGVLCNGKDHTFGLEVVGADDAVVNRYWLLSGKIFLWLDKRDAITSGCPPKVIISKPNYNPHELAVQNKSLRYDQTISRTLQIKSKIKHTGGKTFESAWSQRFAMQNTGYMLEAGNVQQVNASYEGEDRATKDSASYYYAGYSYPMQVRLVQTAPDDNYTYTLDTNLTQTMQLAVTGNTVFSNGLEPFLARITGRVSGSVIQTTKKGRAFFFKKKDGGSSGFGSTRQTYSFGAKTLANGDGIGFADAQSLYSREVMVNNETTTLDNVWVFGKDLPKTKPQGPPQQPIESNEYAARLIGGKRPGTKIGIQWAKEAVLHGNEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V012</accession>
    <name>A0A7D5V012_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nonribosomal peptide synthetase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NRPS1_0</name>
        <name evidence="3" type="ORF">G6M90_00g052700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540397.1">
        <property type="nucleotide sequence ID" value="XM_014684911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V012"/>
    <dbReference type="GeneID" id="26246759"/>
    <dbReference type="KEGG" id="mbrn:26246759"/>
    <dbReference type="OrthoDB" id="5150254at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="5"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="478"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="613" mass="68153" checksum="57C1E983B1B5A7B8" modified="2021-02-10" version="1">MEALRIHKAIHAIVSRHSMLRARFSRGNQGDWTQSVSDKVEESFTFQVERIEDRSNLYKILAERNSAFDISQGPIFAAHLFNINNGSQEQLPLLSGHHLVIDVVSWLVILGDMAEFLIRSKPGLPSLEKPLSFQTWLCSQQEQPQENLVQANGLDSSLNSMQALDLTYWGMTDQANKYGSDVELSFSLDEGETARLLSGYGNRSTPAAAESVDIMVATLLQAFSAVFTDHSILPTVFSEGHGRESADKDVDPSGTVGWFTTLTPLHVVSVDDNIVNTIREVQKARLQMKLLGATSQCCFQQLESKEGLFSNAPLLENEIIIDNGPELNRLALFDVSAIVTGGRLKMTVKYNRRMQHQNKIHEWVMTMHSLLKVADESLSSLNASELETLFAKSGSETKKETLSSKEQMLNNLGVDMANVQEIVPCAALQQHMVSLMAQQSGLGIYEVELAFHITGDNVNTAKLESADLRAGFHEQVVLAHYTANVPVITCVDKHDLVAQAQAYRSVDYRSFNRPHHQLTIFTSNDGAHKACKLEMSHALNDGVSTALILRDVQQAYQGQLKEGPGPAFSSFVFWQNAQIKAKSSDYWQKFARGIQASPIPAKEQLRQDTKYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0J8</accession>
    <name>A0A7D5V0J8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleolar protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOP13</name>
        <name evidence="5" type="ORF">G6M90_00g074360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545630.1">
        <property type="nucleotide sequence ID" value="XM_014690144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0J8"/>
    <dbReference type="GeneID" id="26241663"/>
    <dbReference type="KEGG" id="mbrn:26241663"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="211"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="408" mass="45364" checksum="FEBD4129BF198666" modified="2021-02-10" version="1">MESVKEEAIPQDGEGVTSTKRKSAIDQIEVDLTLPEPPSKRARRALKKGKPLPAKNDSSDEKAKADGDGEQRDKKEKARSEHGIWVGNLPFTITAAELRQWLVDNSGGVITDDSITRIKIPTSKDPGRDKSQKPANKGFAYVDFTDIAGKVAAIAISETELGHRKLLIKDSKSFEGRPAKEKEPEAVETGPDGKIKHGAEQKEEADPNASRKIFVGNMSFKTTEEDVWRNFEKCGEIDWVKVATFEDTGKCKGYGWVKFKQPEAAAWAVKGFVKVKEAVETEDDFNDGDDAEDRKQDQQKQFKTRKWWVNRMLGRELKLELAEDDQSRYKKRFGKDAQRQANGGERKGRPSQGRNGFKSRDEAASDNSGAKTEAPEKAAKPLKEAADIQVARLTGAVVKHTGTKMTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V150</accession>
    <name>A0A7D5V150_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">KIC1</name>
        <name evidence="13" type="ORF">G6M90_00g082320</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543461.1">
        <property type="nucleotide sequence ID" value="XM_014687975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V150"/>
    <dbReference type="GeneID" id="26243638"/>
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    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="45"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="713" mass="78196" checksum="D96BF84B05FBA6F7" modified="2021-02-10" version="1">MATLTAQVGATDSSRNNKSAVEDARRTQSYIAAECANDGTEPPPYELLVLIGKGSFGRVYKARGLNSGRLVAVKIISIEEGDSIRPGGTDTFADILKEVNTLKLLNDRGAKNINRILDAHLVGQSVWMITEYCAGGSVATLMRPTRGLPEKWIIPILREVAEAVYWVHSHGVIHRDIKCANVLITDIGGVQLCDFGVAGIIETKFDKRSTVTGTLQWMAPELFDSSISYGIEVDIWAFGSMAYEVATGLPPNATGLVDMTNFGSFLKHNCPRLKGDQYSPQLRDFVACCMVQDPARRPSIEQVQAHPYIFNTTSKFPTASLSQLVNAYRLWEMQGGSRLSLLSAGGAQGPANISFPSHLNEEWTFDALDEAGLEYNSSDAHTVRNAYEPAVDFPWQPQKQTGRRRQPNMKPLIVPLEQVFDLDFTINYDDNARAFYGQHIELLTNDLRLRDDLDSSTVRESLIDLDASFDGNDLSQVVDMGTIRGVYPSITDEVYHSTRRLTQDWKFPLMAATSASLDYAEDPEENVVCDINARDVFMSQCISSTQSNRASAMSLIDLDASLPDESGILTRPSTAGSDNTSTGSDIEKTPFELEQHVLHAILPSPTVREPSIYVSDDSGFEVPHVPDDGYPKDQHGGLSDQVSVQTQPSLDQGPRCPQHSGPVIPAPPSAGAMLGTSTPDELKGELQRLVWSLGEHLQFTSDTLARLPTKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V154</accession>
    <name>A0A7D5V154_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539993.1">
        <property type="nucleotide sequence ID" value="XM_014684507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V154"/>
    <dbReference type="GeneID" id="26247213"/>
    <dbReference type="KEGG" id="mbrn:26247213"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
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        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
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        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
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        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
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        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
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        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
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        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
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        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
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        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1115" mass="123429" checksum="489E6BE90DDADD29" modified="2021-02-10" version="1">MDRGGDTAASRPNGRAQPNQLHVNHETRRPLFSNKAPRNMGNGPQSASASVGTGARPGALGAVGHIGPARRAKSDPQSMASGFGKAQEDVDANASTASILSTGGSRIPRPNISGLQHRRPISMAEAFKLAQEEEEEAEQERQQGGSPSPAPRVWRARPGQPHDETQARKMMAEDPLDSRARARQYTEAGAPGVQSPNAKPQATELGTATSKRGNGPSLQDRINEWRTKSRPSSDWAEKSPEYLRDASGEPHLPELVPGIEDVPFQSIESPGLNGAILSPSKDYTWQVDHDFTAGDLQVSDSPRIKVGNNSNKPFANRPSILDRIDIRSPARITSPRTRNTRLDEIRARELNVEGGSLAGQSTLTPQHSRRYTKLEEIRARESAAEKQIPIPDRNQPRPKNTRLDEIRQREAEGLSRRALAAARLEEIKEKNAMTRPLSPEKGKSRIENRPEMRPPARPKSAHYEGGEHIPDTPVTVFKSHRPKQENMNPEETGTTHGRGVAAVKPDVNERDLLRRLARAASSSPAPEPVNKRAPLAERQKPNESETVVTKLTLAGRSTNNGRKSALSSHNKVAESSRPSVGFAGLRRIPSTESAKSKPSSMHSESDPTARIEAEAKLFAPRDDYSEPGSVRAPSPVPDSDEEEDDVAEATPKPQKHEFLHMETPRVMGAYVETPVTAKIEKVKEEEAQDIQPLKEKLNDQRRAMSKPDATTLFRDKKTSLAWRNKDEDTASEPGARGEIAGDYAAASAAGKKPRSRSLPRSRSSVKNSAKPPSVKDDLRELQRKHNIEDSTIDDLEDILTGRKHASPKLKELLEELPVKAEDKIDEELRIVEAEIQKLKRENSEDKDMSAGETALYDKMSKNLRTGLSSIHTAKLGIDKLYDQVAQAEKQSTTNEDESKPLQRRKHQHAKDHKNLPDVLCPECTADPGPTSLTYLRFPIPRLFYTSPRFRLSWLGLVVAIVSVWYLAELTVCGKYCRPAACTSTPCVYSYDDPTFGNALPVKIDQWTTGGNGRKLAAWLLEEVEDWAADMGDALSGRSLESISVDQLSAAKRRQHRRRLRKRGLIKLPTRAAPDQTAKWDAWRRSRLEKERSRDMGEDPGDGWLEESLGGDERVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1E8</accession>
    <name>A0A7D5V1E8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="5">3.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ygeX</name>
        <name evidence="13" type="ORF">G6M90_00g090750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-succinyl-(2S,6S)-2,6-diaminopimelate + H2O = (2S,6S)-2,6-diaminopimelate + succinate</text>
            <dbReference type="Rhea" id="RHEA:22608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:58087"/>
            <dbReference type="EC" id="3.5.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541733.1">
        <property type="nucleotide sequence ID" value="XM_014686247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1E8"/>
    <dbReference type="GeneID" id="26245596"/>
    <dbReference type="KEGG" id="mbrn:26245596"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="42"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="12">
        <location>
            <begin position="544"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="751" mass="80524" checksum="0E6CAD2598EF5392" modified="2021-02-10" version="1">MASSRRAMQLNPGAASWCADGSLSADTRLVDRFHSQFPDGSSTRLVRLDEVANHLGIKAVYLKDESTRFGLPSFKILGASWGTFRALVQKLGLPLDADLAAVKDALVRSPIPLYAASEGNHGRAVARMGSLLGVPVEIHVPSDMPSETMKRLEEEGAIVSVNAGTYDDAMGTAREACAARGGLLVQDYSFDDYKEIPQWIVDGYLTMLREIDGQLNGTEADLIISPVGVGSLAQAVVSHYKRKACKTAVMTVEPDTAACLYKSLRAKKSVDVQTYSTIMAGLDCATLSPIAWPLLKSGVDASLTVSDYEAHQASQYLKSRHISAGPCGASPLAALQRLTRKDMADLGLGQDSVVVLLCTEGTRSYRIPMDVSVDGPIALTQALVRIDSSNPALGSVPGPGETEIARYIGSWLEHRDIETHWIEPTKGRPSIVGIVRGSGGGKNLMFNGHIDTVTTLGYDDDPLGGEIKDGKLYGRGADDMKCGIAAAMSALAASKAQALRGDVIFTGVADEEATSIGTEQVLEAGWRADGAIVNEPTGEEIIHAHKGFVWLEVDIHGLASHGSLPTVGIDAITRAGYFLVELDRYSQNLSKGWADPLLAPSVHASTIKGGEEESSYPALCTVVIERRTIAGESVDSVTQELQTILDNLAKSVKDFKYDLRVTFDRAPFNIEPEHPFATLVGGVTSEVQGRKTKFSKGPYWTDCALLADKDIPVLLWGPTGDGLHGKEEWVEVASVERVARGLRMIAQKFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1G9</accession>
    <name>A0A7D5V1G9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g088910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987291.1">
        <property type="nucleotide sequence ID" value="XM_066131341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1G9"/>
    <dbReference type="GeneID" id="90968095"/>
    <dbReference type="KEGG" id="mbrn:90968095"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="89" mass="9941" checksum="42DEB5E3B773C0A9" modified="2021-02-10" version="1">MANSGVEDFSKVASWRQCAPHHARHHVDEKRSSSNLVLEHYRYQPPFAVLSGDNSDRDDEKGKLAPQDAVIFAGFGDGRGWKMSLNAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1I7</accession>
    <name>A0A7D5V1I7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NUP188</name>
        <name evidence="13" type="ORF">G6M90_00g087030</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542415.1">
        <property type="nucleotide sequence ID" value="XM_014686929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244929"/>
    <dbReference type="KEGG" id="mbrn:26244929"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21094">
        <property type="entry name" value="Nup188_SH3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="57"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="703"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="11">
        <location>
            <begin position="1455"/>
            <end position="1820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1826" mass="202238" checksum="542B7E26D8A09826" modified="2021-02-10" version="1">MAPVSDSKYFPSLGECLSGERVLLSWRHVATALADDSGRRQRSTEVVNFLSDDYVHALLKDPSAAFAPPSEAARKDFETKTAPINVTSASTERYDINLLKQDAEWLSRSAKLNLVASLRIAALEVQSRPNRHLLGPLSSQDATNLQEAAGLQNGRGATFMSDFGAGNAQDADEISAEFDAAESRKRRLFSMFLTERRYFIMTMDYLQSIRLYGRLPIFTPVSDKLAALYKLKASPNTKDESVSFLSAYLKVITSSMTSLEAGLKSVTDESILMKEDIELDWLGTLLTEIIHSQSVVFQLVDSLGNDFPPSSVINQWFSLMDLYNFFDTLQPINQTIGELVLPLKTIAVAVSISLLKPARSLTFLAEREEDPTPSDDMYDSYLILSDILEQVHKSVLNAAGMDCESATPVIFAWTLILHRMNVSYQNRTEKRDNLLQQNARETFESGGVVRPMVRRNSAGSIFSIESSKFDGFLENTTTAKDLQVVEQLASGATAHGKVFEIISNMANCLGPSPGGSMTPLLSSRMRNAFLELLKVSYPIVGYQSEPVSALLSLLSPGREYWQLLPDQDLDVGQDVMTSMLQDDYTMEFYFQQALDRYPYEFVPFISMCRALCTASSDSSDKDRSDFILSLLRKTPTISFTLPDAFQSYELVQEDENTNSFCLLEELPLISLSSSWSRRYIEDDAYRLPVGSYGRFITDTGRVVLMDYSHSSLSLLGRQLEINLMKEGYRCELGMLQPDEIAEVISLFATLLRMEYLHTGTASSTALVHSESDLLAEISKHISGGKDIVAVVCETMDYYMQDELAVSEEAAINVLTACVKFLHAILPCRPSRVWSYLARGELLDSDSRAGKLSKITGNLDLVSERFEFLNSSLLLFSGLIDTAMTSAVQRRAGNKMASRQKTDLNPWLGTADKVLTKVSLSVAHASVDAFESTSTWRFDNAISRTLLLDSVVPVLNKLVTYSYSMGESPTSDSLTACLRPAASYVIDCFMTPASGTLRFQPILSSLVDAFRMPEATLYSTRNTIARRQANSILHFSTTLLRAANYLERSSTMIETYLFKSSTLLARLCAVSDVFRAGAIGLLESLVVNAASAASEPPSLLGYLGPQISKSFLQVLAHLGRPFNLTLEVGTIWRFFSSILRNRQQWMSNCLLTGQTPREAMKQETKKGDLSSDSVFATALGRLKKLKELESEEALAILDFVASAQNYWPWTVFSLLKDTTYTDGLRAYVRDLRPSHLTVKSDALQTAVDARVAAYVAETLAMQLYHLRHQGAPDTLAKSLVADMDYYIRDGVEVSGYNKSLHNNFAKNFANKYSGCSLDNFKRTVLEPRELGKNYYYDLDRATDMLSFDPGWLGRKDNGFKNEMELANANLSLVDAQIALFHAWEFLLVELSTSLPNDKTVAKQMLQVAQQCLNANQGAPGPESIFVKLIDARASLALVLVQRLAKLSVPVQDVNQLLGTLTGTIHGVEEPFAKESIAYYRTLLKALFVTLRSYHLSDTKGLSESSVNLGSSTVTVTQTVLNLLDHIVGKGFRSLVSLIHDNDSDMSPEDLGLLTAILQACLSMPNMDQSQTQILNIMAAHDVVNAATSLFSWADKLAHQGDPVYGELSILFLLELSTLPLLAEQLACDGILGSLLSANLSKYMLRSTISPYADAPFAQRCYAIWAKGFLPLMLNMLASLGSTLAPEITYVLNQFSHLLEASVDRFEAPGASRTKSKSTPQYLTLLATSEIHSLALLTRVLSALRANNNRDIPAVEWDAAGLLENVEFWLSSKRLLKERLLPLGSRETEWKNIRKEAGIAGGSESLLEEKIVSQLETVRDVLSEELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1R8</accession>
    <name>A0A7D5V1R8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase 10-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">stk10-a</name>
        <name evidence="3" type="ORF">G6M90_00g084620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543678.1">
        <property type="nucleotide sequence ID" value="XM_014688192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1R8"/>
    <dbReference type="GeneID" id="26243855"/>
    <dbReference type="KEGG" id="mbrn:26243855"/>
    <dbReference type="OrthoDB" id="5141198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="311" mass="34913" checksum="CD13152CC6D1F3FD" modified="2021-02-10" version="1">MPLREGSLKSLITDKNFHDYEHLYFDVVTQMLSALDYLASARLVHRDVKPENILYYSSGQIAGSGYHFQLADFGFAHYHDLATSKCGTGYYRAPELVPEKSKVDAPQSHKMDVWSLFATMVAVDSKFESFPILTSDYGIILKTLLAKARESPLYAHMGRLHPDCRASAAQILSEHFAGWGLSTPQSRITPIEPELELQEAAPQNLLPTAGPRAPREMENDHDMENDHGMGNDHEMRNDHGKPRQKAASSLGRLITYPPPWSHKQQGIPVNKNGVRKRRARRSARPSPRQQRLLVRNEPEKGGPPVPGAFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1U4</accession>
    <name>A0A7D5V1U4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987480.1">
        <property type="nucleotide sequence ID" value="XM_066131269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1U4"/>
    <dbReference type="GeneID" id="26246066"/>
    <dbReference type="KEGG" id="mbrn:26246066"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="56280" checksum="DC44A754F2DB72A5" modified="2021-02-10" version="1">MAAVSSTPTGAAALTPLSGSHGEGVWDYPGAQPEKTSQDGQNEPRPDEPSRGAVGSQNGNALSSSYAQAGNDFEMAARKTHSSDNLNVSKWDKSGDGNAGLSPALAVESRQGQPNPSEDAISGKHGGSEEHRRHIQQTLGFEYSEEDSKWIHRDKLAKIESEELQAAGFIMPRVRASSKQRRPRGQNSIDIDNQHQNRQRHDSAVMGQVGEESYSSPCWDLRTPEEIAEEEANAYFSSQSLRGGTKIPVAKISPAPIPQDYLERGSPSVRRIESMDGDTIAYTKTRSRSASASTRDFEAVHNGSRSATAKRSVTESSPKKTTVRKTSTASKTSTTPSRPKTRSGPNRDVSGTRPSTRSGEPSAASKQPEGDPPWVFDSYKPDPRLPPDQQLLPTVAKRLQQERWEKEGKFGDVYDKEFRPLNDHEFPRPQEKEPVPPEVEDLSQAGDWPLKSGIAKSPKQGSYSTMPKISDKPAVTAVANPKPPGPQPIPQPEDVGEPTIQAEQEAKKKAGCGCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V245</accession>
    <name>A0A7D5V245_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase trt5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trt5_1</name>
        <name evidence="6" type="ORF">G6M90_00g084020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543618.2">
        <property type="nucleotide sequence ID" value="XM_014688132.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V245"/>
    <dbReference type="GeneID" id="26243795"/>
    <dbReference type="KEGG" id="mbrn:26243795"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="383" mass="43923" checksum="74290147075EE14B" modified="2021-02-10" version="1">MSPALVHTRQPLRLDTSRSTLAVVQTKGIRDSLRRLSPSETFEIETLHILDNKDKSTALYDFGQKSLEQPIRFVHFPKNNFPISQTYLPMDKATLEPAMETGPEKAKTSWQEYAYIKELPDDIAPFKELLQQYSKVPPDKVDELLLRTRDRLWDVVNYPCIGLWAFTKLHSTTDSRFEAATQRLLAEDPVESGGTRPAILDIGCCIGQTLRHLAHKGVHPSRLYGTDLRPEFIRIGNELFGDEQRGLTFVAGDVLNADDSSMKELDGKVTLIHAAYFFHLFTWDDQVRIGERMVRFLQPGTSDAVVFGRHIGTLRPRELEVPTTRASRCYLHDGESFQRLWDEVGSRTGTRWRVEAEMADRLHVRFPFFGDDEKYMSFGVYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2R9</accession>
    <name>A0A7D5V2R9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g092950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541939.1">
        <property type="nucleotide sequence ID" value="XM_014686453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2R9"/>
    <dbReference type="GeneID" id="26245407"/>
    <dbReference type="KEGG" id="mbrn:26245407"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11404">
        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="286"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="353" mass="39275" checksum="33A9164E9924DE79" modified="2021-02-10" version="1">MTVDATRQHYYPDFDLFHDLPGLWPEVPSSHLDARPTQNPCSQFGLVAQMALHANMMPEFASLQSLPPGQPWAAREAYRPQPQSSPCSSPLQSQYNAEQETHSRHDKEAGHDTSRRGQRCQSRSLPVGHLRHQSSVDFGEDLLRNSQNTDVDENIFADWAWGPRQPSGRRAVHEGSMQFGSDSGFDSPRGSLASASGDDMETEPSPPPPPQSEGPGFTALSFGYRNQAPRPAWPVLRTRTGSLDPEASVASTWRALSWEYLGAAMHERKPLLATVGPRREKLTEQQKRRNHILHEKKRRALIKEGFDDLLDLVPGVRDRGLSKSAILLRAAEWLGGLVCENKALRAQARALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3K8</accession>
    <name>A0A7D5V3K8_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g096480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691200.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241109"/>
    <dbReference type="KEGG" id="mbrn:26241109"/>
    <dbReference type="OrthoDB" id="4502894at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20895" checksum="26A2946A566D8FCE" modified="2021-02-10" version="1">MPESSSSSFIDTIVHILQPIRSLNWTRYLGLITAALSLPLRLAWIPLSRLLALVTTLLAPAGYVLAYLGSWAAAVARFLVSLEPLYTFFSVAAFIGVVAGVLVAVASAVVTTYFNMQDEPEDASSHRRRPPRKQVYLEQQYLRPEPQGLEPDWHWADTAQAQAQSPARLRRVSGLQTETILEEDDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3V5</accession>
    <name>A0A7D5V3V5_9HYPO</name>
    <protein>
        <submittedName>
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    </protein>
    <gene>
        <name evidence="2" type="primary">phnZ</name>
        <name evidence="2" type="ORF">G6M90_00g111440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688234.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26243107"/>
    <dbReference type="KEGG" id="mbrn:26243107"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OP_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40202:SF1">
        <property type="entry name" value="HD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="219" mass="23409" checksum="174132520D77E073" modified="2021-02-10" version="1">MAMPIPSPLEPKSVTSYLLSVLEASDQTPYIGEPISQLQHSLQAAHQAASASPPADEATQVAALLHDIGQFVPGRDLISLTGGQAENLGGAATGESVGRVGHDTLGGAFLLALGFSAKVARLVASHVEAKRYLCAVESGYYGKLSDASRKSLAYQGGPMRGKELADFGGDPWCGEMCRLRVWDDEAKVQGLQVRSLESWRCVIERQLDDQRRVADGEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V452</accession>
    <name>A0A7D5V452_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HET-E1_10</name>
        <name evidence="6" type="ORF">G6M90_00g096190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546713.2">
        <property type="nucleotide sequence ID" value="XM_014691227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V452"/>
    <dbReference type="GeneID" id="26241136"/>
    <dbReference type="KEGG" id="mbrn:26241136"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="385"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="510"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="592"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="648"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="690"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="751"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Cullin N-terminal" evidence="5">
        <location>
            <begin position="808"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1199" mass="134594" checksum="3BDA18B4F98A4A6A" modified="2021-02-10" version="1">MYKEVLDEAAVGLDRHEKQLLEDVLRSIFLLFTPLSSKCLAALLGKNDRDVDCLLPNLHAVLDIQHGGPVKILHESFRDYLLDQEGAFRVDALETHMMLTRNCMDRMKRNGKGPSHGLHRDMYGNGDYSTTTNDIGHAINNFIPPDLEYACLNWVNHLQSFQQDLGQIIDEDRNEALLQEMPALLKEVKTLLDEHLLHWIETLSLLGRLSDGISSIKQLRTILLSRYDAASNFDAFLRDAERFALSYGFMIERFPLQTYGAALTFCPTDSQVSRRLGVERYPDIPTLRGARIGWDHCLYTLKGHGGSVNAIASSSSRKILASASSDRTVRLWDDVTGAHKRTLQGHRGYVLDIAFSPDGNTLVSASSDCQVWVWGVNEGNHIRTLEGHRNWVNSVVFLSNSTIASASSDWTINLWDINHGICKTVLKSHSGSVNALASSRNGKVLASGSSDRTVRIWNIAEGTPIMTSLDHDGSVTALSFATDGRFLASASSDKAVRLWDADTGSQIRMLEFHGDWVNSVTFINNITLATASSDRTLRLWNITTDNTQKFEGPGGWFNSTAFLADRNILVAASSDRTLRMWDGIMGGSEQMREGHDGSVNAVAFSPDGTWLASASSDRTRVRFWDVDEGTLIKTLAYRNHIIRDEGTTEDHSRYVLAIAFSPNGKVIASGSSDWRVRLWRIDESVPLTTLEGHRNWVRAVAFSTDGKLLASASTDGTLCLWDVEKRNDETSIYEDSASSILRERYCDADRRTHDQDWVRAVVFSPDGKVLASTLTDGTVSLLDLNKVNSIRTHDFLAVAFSLDVFNGADYLFTKLADYLKNYLEQVIDETKAHTGEGLLTFYNREWPRYTEAAKYINHMFQYLDRFVGQATEEGTTSIYDVYTLHLVQWRSVIIGSISENIIEGVLGLVERKRNGEIIENGIIKRVVESFVSLDIDHDDPLTTYRYYFETPFLEATRLYYRAESKHYLAENGVVEYMRRAELRLDEEDELVRACLHHNTADPLRQICIQVLIAEHSEILRNNFQSLLDTGREEDMARTVNLLSRMPDGLAPLLSKFETHLRKAGLSAVINAASAAEKLESKLYVGPVSAQYHDLVRWALSEDGHRTRSSDNICRELVSQLDVCKWGSDKFPESLSKYNAKPTEAEGSADVISSTEDWIARDGHNLLCLPPDYRATCAARWNNILVLGHKSGLVSFFQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5C6</accession>
    <name>A0A7D5V5C6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cog8</name>
        <name evidence="9" type="ORF">G6M90_00g110040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543852.1">
        <property type="nucleotide sequence ID" value="XM_014688366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5C6"/>
    <dbReference type="GeneID" id="26243239"/>
    <dbReference type="KEGG" id="mbrn:26243239"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="423" mass="46610" checksum="662CD32D24E3A29E" modified="2021-02-10" version="1">MAEALSDRLLGQGKALDATVLSYLTYLAGQSVESIRTTEPQQLSQASNSLLLSVQSLSKKSHRPIVESAASHSALRQLFALLAKRTGELTHTVPRLDQEAELFSSEFGKASENSSITERKKALRLLQNGERLVDMMELPQLLNSAVTSSPVSYSSSLDLYAHVRRLASLYPSSPLVASVLDEANSAIRRMAVDLIATLQTPNLKLAPSLRTMGWLKRIVPELVTNIQTEESLPAIFLVCRLSTLIATLDALDPLKQLADEERIRDVKISQAWSGGQHTERYLKRFIEVFREHSFGMISVSKSVDSSFSHSDSAATDPMNPLPSVLTSFPLHLIGLLMDTLQTYLPVIKDQASRESIMTQVLYCAGSLGRLGADFGMFLSAIGMAEWVELVKRHRLLAGRLESVIGEHRTSQTTPTSLVIRDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5N5</accession>
    <name>A0A7D5V5N5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g102640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546084.1">
        <property type="nucleotide sequence ID" value="XM_014690598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5N5"/>
    <dbReference type="GeneID" id="26240507"/>
    <dbReference type="KEGG" id="mbrn:26240507"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="58046" checksum="E986BDC2B441B88C" modified="2021-02-10" version="1">MAGVVDPEFANKATTTLEKPEMSQTPPRFVIIGAGSRGNAYADAIEKVSNGVVAAVCEPIKFKRESLGQKYIWGSGSPQEGQSFTSWNEFVDYEKDRRKRAAAGEEVPEGVDGAFVCVLDDMHREVVVALAELDLHIMCEKPLATNMDDCLAMYKAVKPLKGSKIFSIGHVLRYSPHNLMLRKLLVDEQVIGEVNSVVHTEPVGWWHFAHSFVRGNWRNDKTSAPSLLTKSCHDIDLLLWLVSAPAKAGQGEAHLPDYITSTGGVQFFKKSRKPAAAGNATNCMKCPLGDSGCKFSAKNIYLGDRIGLARGNTKWPVDIVVHDIEDYKTDEERRQVMVKTLSEDWDESTPKEEVSKRQWYGRCVYETDNNVCDEQFVTITWPESVRPAKRVTFHMSAQTKRQCERVSTFYGEHGEIHADSRKIVVENFATGETKTYEPTVTDLGHGGGDTGLAQQFVLACDKVKNHGWDGERAQNEVVGCTLDDVIRSHALVFAAEDARVNKKIVDWGQWWDDNVTKAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLI7</accession>
    <name>A0A7D5YLI7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DED81</name>
        <name evidence="14" type="ORF">G6M90_00g004650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542114.1">
        <property type="nucleotide sequence ID" value="XM_014686628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLI7"/>
    <dbReference type="GeneID" id="26245145"/>
    <dbReference type="KEGG" id="mbrn:26245145"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="267"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="568" mass="65149" checksum="A559F86FF3DB57B1" modified="2021-02-10" version="1">MATIYIDEDIGKDEPTQQGTEQSPFKTLQFAYLQHPAQAQYLTRKSESADDEAAREWKPAAKSAMKKVVNYFEQQKKKAAREQELAIHRKKEEEERHKVLDEAKKIVLEEDPSLPKPVTIKLDEAGDHIALRKADDADSKGTRVRVFGRVHRERKQKDVLFVTLRDGYGFMQVVISGKLAKTYEALTLTRETSMEIFGEMREVPAGARAPLNRELHADFYKIPKHWRAVGGDDAITNRVTASTEHSTLLDLRHLTLRGENASSVLLVRDAMEYAFNRAYHEARIRKVSPPALVQTQVEGGSTLFKFDYYGADAFLTQSSQLYLETCLPSLGSVYCIEKSFRAEKSLTRRHLSEFTHIEAELDFINFDDLLTHLETLICRVLELVLEDPMIAGYIKTLNPEFKVPERPFMRMRYSDAIKWLIDHEIPNEEGNPHNFGDDIAEAAERKMTDIINKPIFITHFPAHIKAFYMKRDPEDDRVTESVDCLMPGVGEIVGGSMRIDDYDELLAACKREGLDPEPYYWYIDQRKYGSSPHGGYGVGLERLLAWLCKQHTVRDCCLYPRYMGRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLJ4</accession>
    <name>A0A7D5YLJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g029090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985796.1">
        <property type="nucleotide sequence ID" value="XM_066130022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLJ4"/>
    <dbReference type="GeneID" id="26245893"/>
    <dbReference type="KEGG" id="mbrn:26245893"/>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="137" mass="15167" checksum="B1B28031A740A8FF" modified="2021-02-10" version="1">MTPVDDGHISLRLKHGIHTIFMFADAQAPMSEITKELLELLSERYPEGLTTVVSPLKTMAIPANPRLAYGVLNVPNDPSRGWKRIKTGEDESSTPTACGLKNNSIVAFSFVSGLEDEDVLFEVEWPKDDDEMYDQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPU1</accession>
    <name>A0A7D5YPU1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcium/calmodulin-dependent protein kinase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cmkC</name>
        <name evidence="6" type="ORF">G6M90_00g013380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986001.1">
        <property type="nucleotide sequence ID" value="XM_066129746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPU1"/>
    <dbReference type="GeneID" id="26238627"/>
    <dbReference type="KEGG" id="mbrn:26238627"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="97"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="655" mass="73618" checksum="DCA62190DE17CB20" modified="2021-02-10" version="1">MATNTAPSSHGQQVTGLCSPRLIVARVDDNEDTMDRSRPSLPSSFSEPPTLHGYSSPMRQHKRTPSAHREIKETLDARVEFTSDEADGRTYHRINQYVIVEEIGRGSYGAVHRATDQFGTEFAVKEFSKSRLRKRAQSHILRLGPQSSPGQYLPRPRRACGPLSPQLTGLRAGEENDALFLIREEIAIMKKLNHPNLVQLIEVLDDPEEDSLYMVMEMCKKGVIMTVGLDENADPYNDESCRHWFRDLLLGIEYLHAQGVVHRDIKPDNLLLSDDEVLKIVDFGVSEMFDKPENMRISKSAGSPAFMPPELCGKHQEVSGKAADIWSMGVTLYCLKYGKIPFNRPTVLEIYEAIKSDDTCIPDGEDPAFVDLMTVILEKDPEKRITMSQLREHPWVTKGGCDPLLSAEDNCEHIIEPPNELELNRAFTRKMNHLLSMMKAIHKFRTLLARIRARNNTGVVGSSTSLQRLMSEDESFNAADERAKAEEIEALLARRRHLLSQQAEDADKGHAREIGEQEPLLLGIGTGARDAFAWDEATPDVVADSPTAVDFDVYDRAYEEAIKRGMEARPSKKPTMYLTKLVKETDYFKKIENLVGGTVPSPPSPKTEVKKATHVLRDRLPSEPRAKLAEIIDKVALSTPETEKDMEQPGLERQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRQ2</accession>
    <name>A0A7D5YRQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543154.1">
        <property type="nucleotide sequence ID" value="XM_014687668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRQ2"/>
    <dbReference type="GeneID" id="26243955"/>
    <dbReference type="KEGG" id="mbrn:26243955"/>
    <dbReference type="OrthoDB" id="3505753at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070819">
        <property type="term" value="F:menaquinone-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052200">
        <property type="entry name" value="Protoporphyrinogen_IX_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38030">
        <property type="entry name" value="PROTOPORPHYRINOGEN IX DEHYDROGENASE [MENAQUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38030:SF2">
        <property type="entry name" value="PROTOPORPHYRINOGEN IX DEHYDROGENASE [QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20375" checksum="FD4CA5B7075EAA65" modified="2021-02-10" version="1">MAVLVSYATAHGSTREIAEAVARQLSQQLAPIPVDCIPAAATPLLSSPEGNKYKAVVIGSAIHVGRWIAPGRRFLKQNEPYLSSGNPDVPRVWAFSVGMPPTDDDLAKEEVSMDKWLRERLRLQGHRLFRGAFDKADLPWIIRLIFACCVPEDKTRFGDSRDWPAIRAWADGVGTRIKEEAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS82</accession>
    <name>A0A7D5YS82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g055160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986856.1">
        <property type="nucleotide sequence ID" value="XM_066130595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS82"/>
    <dbReference type="GeneID" id="90967792"/>
    <dbReference type="KEGG" id="mbrn:90967792"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 C-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="151" mass="16504" checksum="28F4F02C6009D02B" modified="2021-02-10" version="1">MDIPRIAHGRPGALGKAVIFGLQENQTPIRSRGALFDAADSGAITLTSYTSSLGQFLSDACIVFGSPGIRLVDGFIDHLNATAILFIHLPGQQSGMALVFLLWGQSNPSDKLPYTVAKRESDYGSPQFYFEWEQSTPEQLYAGNLHKLQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTY1</accession>
    <name>A0A7D5YTY1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase transmembrane component 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FRE6</name>
        <name evidence="13" type="ORF">G6M90_00g006420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549865.1">
        <property type="nucleotide sequence ID" value="XM_014694379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTY1"/>
    <dbReference type="GeneID" id="26239309"/>
    <dbReference type="KEGG" id="mbrn:26239309"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="172"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="11">
        <location>
            <begin position="354"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="12">
        <location>
            <begin position="456"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="645" mass="72234" checksum="5C55E5FD04FA5CA1" modified="2021-02-10" version="1">MLEPRHIQNHSDASDTQAHWGYPDRVVPCKNDAGSCAYLDVVYLAHDLGMLYMGILWATIFGVIFLWVLLRRASRPAVQGTLQTSKSDQGALSKLRKTTAVASRRFLLRDANHFLFGRTTRFQVVVLALLSGYLFIWSFLGITYNTWVTPVKNMPGVYNTRTSLGPWSDRVGVIAYALTPLSILLSSRESLLSVLTGVPYQSFNFLHRWLGYIIVIQSLLHTIGWLIIQLNLYQPQPKVSLEWIVQPYIIWGIVAMILLLIMFILCTPWGIRATGYEFFRKAHYVLAMVYIGACWAHWNKLECFLVPAFILWGVDRGARFVRTGLLHYHPTSSAYAGFKPAQALITRFPDPEHGEIIRLDLENEQDAWKIGQHYYLCFTESSIWQSHPFTPLNAPVVEKGLVKHSYILRAKSGETKKLAELAAKKLATSQHETVATPVLLTGGYGEDLLEKIDRDTNIICVAGGTGIAFVLPVLLHLARTRSPSDRRIELIWAMRHSRNADWVKDEMAVLRNAQKELNLTISLFATRDAAGSGKESHQPKDADIVSSSSDDICPCDEKTTCPPGISVDKIGDGADDESRHPDLSRMVGAFVEGTVAGRTVVFASGPGGIITDLRSIVAGLNVPGKVWRRDDRFDVELVCDDRLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV86</accession>
    <name>A0A7D5YV86_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539328.1">
        <property type="nucleotide sequence ID" value="XM_014683842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV86"/>
    <dbReference type="GeneID" id="26247871"/>
    <dbReference type="KEGG" id="mbrn:26247871"/>
    <dbReference type="OrthoDB" id="5120271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015141">
        <property type="entry name" value="PLipase_A2_prok/fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09056">
        <property type="entry name" value="Phospholip_A2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="144" mass="16681" checksum="734DE29F2F34D90D" modified="2021-02-10" version="1">MGNTSHAINGHQHHTRFPDCRQLRKSRNAKGPSGCNWSSDNCSWSPDKPDGFNFIHSCHCHDFSYRNTKTQKRFTSDMKTRIDDNFKKDLYKHYSQFSGIWSFKGVECRRIADIYVAFVQKLGKREGDELGFILRDNSGLGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVH9</accession>
    <name>A0A7D5YVH9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tsn1</name>
        <name evidence="9" type="ORF">G6M90_00g077530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545349.1">
        <property type="nucleotide sequence ID" value="XM_014689863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVH9"/>
    <dbReference type="GeneID" id="26241382"/>
    <dbReference type="KEGG" id="mbrn:26241382"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="248" mass="27779" checksum="9BFEB55B0D6EFD38" modified="2021-02-10" version="1">MSTQSSLLDPSIFSYLESKIEEETEVRDALTQIVQKLERSVASAQALLSRVHSTPRARYPALVEQVENAVKDEVAIVKELNEVASKHPYYKYNSKWARTVQNAIGTTLYCAWLGGFPSDSQPPELGRLLTLEDVGSIFSVPTNLKDRDAFHFTIEEYLLSLTDLTPELARLATNAVTLGDFQLPMTISAFIKDVFAGFQLLNLKNDILRKRADAVKYDVKRVEDVVYDLSLRGLVARTGGDTEMKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVI8</accession>
    <name>A0A7D5YVI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g024680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548114.1">
        <property type="nucleotide sequence ID" value="XM_014692628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVI8"/>
    <dbReference type="GeneID" id="26237558"/>
    <dbReference type="KEGG" id="mbrn:26237558"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028812756" evidence="2">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="24570" checksum="AECE7CA4AE9DDFB6" modified="2021-02-10" version="1">MARQSLVAGVAAVAVALVSAADSTTTVSMLQPLADDGEGLTLRGSVVGVDGDKTTYGFGCEAGASADSCLPEGTSMTVVQGPSTLVQSIQATMSDWDGKVGGDEAEDAEDLLHQSAVVSLEHSCKLNPDQNRAECGVMAAVAVGSATFVSQGSDVLTAYKDMVFPVVITAGVDKLSPAPGATQTGNVPAATGSAGASRTTSLATISGSKAPASTASASTAGATTTNAAGAVVPRRLGLAGVAAGIGAALLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWZ7</accession>
    <name>A0A7D5YWZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine aminomutase L-beta-phenylalanine forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cctP_3</name>
        <name evidence="3" type="ORF">G6M90_00g111630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987933.1">
        <property type="nucleotide sequence ID" value="XM_066131834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWZ7"/>
    <dbReference type="GeneID" id="26243091"/>
    <dbReference type="KEGG" id="mbrn:26243091"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="784" mass="85392" checksum="B3481ED0A79D6E9B" modified="2021-02-10" version="1">MSVYLNSHFELASRLFEDTEAYKPGQKVIITGQDLEVSTVVAVSRGRCQPQLTKDETTSRRIRASVSRLAEYLGSGNTVYGVTTGFGGSADSRTTETGKLQLALLQLTQNGVLRESDKTADNANGNFEHHTEISCYPTAWVRASMFVRCNATARGHSAVTLEVLQAILRLLRHDVVPIIPLRGTVSASGDLMPLSYIAGAIEGNPDVVVRTTLGTKSIIQSASEALERENIQKIIFGPKEAVGLVNGTAPSAAVAALVMYEAHHLATLTQAITAMTVDAMTANAESFHPFIALVRPHAGQIEASKNILAFLQDSSFAKGIKTVKESNPSGLAQDRYALRSSPQWIGPQLEDLLSAHKQITTELNSSADNPLVDGDSGDVYYGANFQAAAVTSAMEKTRIALQMLGRLLFAQSTELIDPNLNGLPANLAADDPSTSFTMKGVDISMAAYASELCYLANPVSSHVHTAEMHNQSINSLAFLSARMTKKAAELLSLMAATCLYIVCQAMDLRAFQSEFLSELQVAIDTLSKEVLAEHIEQPDLLELNLALRRCIESSWKDASRLDVPDRAKAVGDATTLELIKAITLNQSSSSKFASLCIIESWRHEVENITMRVYGIVKRKFFACPTTEKYIGIGPRALYMKIRHDLGVPFHQGLVEHPVSQGKDERIQGKTARPRKTIGSWVSIIYEALLEGKIYDAIYRCLPREAENAASNGGVSASDIISNTRPRSIESAAPSSSLYETSSIRKRKLSQDHLACARSQEHRPIRYRLNLVDSSNDTTNSASME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXC0</accession>
    <name>A0A7D5YXC0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g087180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542400.1">
        <property type="nucleotide sequence ID" value="XM_014686914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXC0"/>
    <dbReference type="GeneID" id="26244914"/>
    <dbReference type="KEGG" id="mbrn:26244914"/>
    <dbReference type="OrthoDB" id="5371646at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="231" mass="25142" checksum="78F4E4C59DE3FCC3" modified="2021-02-10" version="1">MELSFTQDEKRFVLAEIIKSSTVKIDLLLAFINTNRVDPDWMRMQLPLGRNMNQCMQVVEHMGGPSSNSKRLSTSSQGEPVLKEADSSVAGDTTSLNTQHLSPPVSNVPVPILPRPSKGLEQNQVAMPPPQSTTKPKKRGRPSRADKAKRDLRPNLPPHIAPRMQHGTGHRPILPAIPHPLNNPAQPGLSLFATVDTRKAKKRKMVTPLGQPQPANPSTLSTSSVVSSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXW1</accession>
    <name>A0A7D5YXW1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g058180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986654.1">
        <property type="nucleotide sequence ID" value="XM_066130660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXW1"/>
    <dbReference type="GeneID" id="90967818"/>
    <dbReference type="KEGG" id="mbrn:90967818"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="136" mass="14230" checksum="91ACDF3BC183C6D3" modified="2021-02-10" version="1">MPAIFRYIICVFGASANTASLVTSSALVSPQEVPATAARACGPECDTARYCSVPQGPFSYQLESGGIWASSQLGDAQPAGQTAQAGGVLTSQPNAFFDQESKMVMFSGRVRDMSPKLAVTGCEKGRSTARNKDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXX9</accession>
    <name>A0A7D5YXX9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">dis3</name>
        <name evidence="19" type="ORF">G6M90_00g098750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546471.1">
        <property type="nucleotide sequence ID" value="XM_014690985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXX9"/>
    <dbReference type="GeneID" id="26240894"/>
    <dbReference type="KEGG" id="mbrn:26240894"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="18">
        <location>
            <begin position="890"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI73162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="986" mass="111381" checksum="37574E1FC89AF70F" modified="2021-02-10" version="1">MTSLKRSHEGDSLASNISSKVYVRSTRSGKVQKIVREVYLRTDIPCSSKLCRACLEGAPRNASQQAQPFVLSEKPAATKAFPQGHYLVPDTNALLNAMDLFEQSSAFYDVIILQTVLEELRNRSLPLYNRLIGLTKSEDKRFYVFFNDFRLETYVNRELNESVNDRNDRAVRMAVKWYGEHLSGTKAGEVPAIVMLSDDQENLKKARSQGLNSLSLRDYVGSLEDGDKLLDMVAESQSLSLGGFKKQSQMLYPEYYSLSRMMTGVKAGLMHQGIFNVSPYNYLEGSIKVPAFSKPLLILGRESINRAVDGDVVVVEMLPQDKWKEPSTKIIEEDNITKNENADTEDRNDFVSDKERKALQEEAKRTHKSSSESQLQPTAKVVGVIKRNWRQYVGHIDPSSASKSASSQGRKQDSVFLIPMDKKIPKIRLRTRQVSELLGKRLLVTIDAWERDSRHPVGHFVRSLGELETKAAETEALLLEWDVQYRPFPKTVLDCLPKEGHDWRVPASVEDPGWKDREDLRGLLICSIDPVGCQDIDDALHARKLPNGNFEVGVHIADVSHFVKPVNAMDTEASIRGTTVYLVDKRIDMLPPLLGTDLCSLKPYVERYAFSVLWELNDNADIVSVRFTKSVIKSREAFSYEQAQLRIDDTSQQDDLTNGMRMLLKLSKKLKKKRMDAGALSLSSPEVKVQMESETSDPIDVKTKELLDTNSLVEEFMLFANISVAAKIYDAFPQTAILRRHAAPPKTNFDELADQLRVKRGFELRTDTSKALADSLDACIDKSDPFFNTLVRIMATRCMMSAEYFCSGTQAYPEFRHYGLASEIYTHFTSPIRRYADLLAHRQLAAAIGYEAVHPSVRSRGRLEAVCKNINVRHRNAQMAGRASTAYYVGQALKGNVAEEDAFVMRIFSNGFVVLVPRFGIEGLIRLRDLAEPEPESEFDAETYTLVTRGSRDLKVELFQKVKVKVRDEKDERTGKRGVKMELVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY25</accession>
    <name>A0A7D5YY25_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">tif211</name>
        <name evidence="12" type="ORF">G6M90_00g021610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548387.1">
        <property type="nucleotide sequence ID" value="XM_014692901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY25"/>
    <dbReference type="GeneID" id="26237831"/>
    <dbReference type="KEGG" id="mbrn:26237831"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI63987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="315" mass="35932" checksum="596DA7F446906201" modified="2021-02-10" version="1">MSLTNCRFYEEKFPEIDSFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSPEDMVKCEERYNKSKTVHLIMRHVAEKTQTPIETLYESIAWPLNRKYGHAIDAFKLSITNPEIWNDMTFPSKPVEDELKLYISKRLTPQRTKVRADIEVTCFGYEGIDAVKTALRTAEAKNDSEDANSDTQVKVKLVSPPLYVLTSTSFDKQQGIILLQEAIESIRKSIEAAGGNLTVKMDPKAVTESDDAELQALMEKRERENAEVSGDESMSESDDNIPETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY34</accession>
    <name>A0A7D5YY34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding monooxygenase moxY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g093000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541944.1">
        <property type="nucleotide sequence ID" value="XM_014686458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY34"/>
    <dbReference type="GeneID" id="26245412"/>
    <dbReference type="KEGG" id="mbrn:26245412"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="67901" checksum="AD2160F340DC5483" modified="2021-02-10" version="1">MTAATEEPPPQGHTQRHQNGGTPFIKGRTLQQDVHGSSGPPELSYELPKVSLIDRFIDEPRPLQVAVIGGGLAGILAGILLPAKVPGIELTIIEKNNDFGGTWLENIYPGVRCDIPSHVYQSTFAPKKDWSDKFAPGHEIRDYWQSVARKYNVYKYAKFGHRVDAARWDADAGKWSLRVTETKSGSASTVEYDFVIAAVGRFNDWKLPEYPGMSEYKGTLRHASNWDATFDPAGKTVAVIGNGASGIQVVANLQKKVARLDHYARSKTWIATSWAGDERTLDAQPISQDEQGGFQDDEAYLDFRKALEDKYWRRFDSFFRGTAENAELKANFTSVMKRRLAGKPELADQLVPDFSPNCRRLTPGPGYLEAIVQENVDYIQTKIRRFTASGIETEDGKHRAVDAVICATGSRSDLVPALSITAHGKTLAELWRQDGVYGFPYTYLGVATPGFPNLLFLHGPHGTGPSGTVPHSVETQLAYFAKILRKVSREGIKAVGASGAAADDFVQYCDAFFADTVLSDNCSSWYNGGRAGSRIHGVWPGSAAHLSLVRREPRWEDFEYEYLGGAGNRFLWYFGNGKTRKELDPGSDMTSYLKSPADMDLRELHESWWDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYE7</accession>
    <name>A0A7D5YYE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">idh2</name>
        <name evidence="16" type="ORF">G6M90_00g006310</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549876.1">
        <property type="nucleotide sequence ID" value="XM_014694390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYE7"/>
    <dbReference type="GeneID" id="26239320"/>
    <dbReference type="KEGG" id="mbrn:26239320"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="52"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI64227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="381" mass="40950" checksum="06E1DBA45631A1D3" modified="2021-02-10" version="1">MLAIRAISRPAVSRQCLRAAPRASWAVARCYSTAGERVAKYEGTKDAQGNYLVSLIEGDGIGPEIAVSVKDIFAAAKTPIAWESCDVTPILKDGKTAIPDAAIENIKKNKIALKGPLATPVGKGHVSLNLTLRRTFNLFANLRPCRSVAGFKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRFAFQHAQSIGRTKVRVVHKATIMKMSDGLFLNVGKEVAKDFPGIEFDAELLDNTCLKMVTDPLPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKALANPTALLLSSIMMLRHMGLTEYAVRIEKAIFDTLAEGKALTGDLGGKAKTHEYAAAIIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYT8</accession>
    <name>A0A7D5YYT8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g032830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543214.1">
        <property type="nucleotide sequence ID" value="XM_014687728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYT8"/>
    <dbReference type="GeneID" id="26244015"/>
    <dbReference type="KEGG" id="mbrn:26244015"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="36911" checksum="FDE04874EA730F8F" modified="2021-02-10" version="1">MPHHDVLVTGSSGHLGTALMLTLPSLGFNPVGIDILASETTQHVGSVSDRALVSGILQANPIKHVLHTATLHKPHVESHTKEQFIETNITGTLVLLEEAARLGNQVESFVFFSTTSSFGLALSPEPGSPAAWIDEAVVPVPKNIYGVTKVAAEDMCALVQRQTGMPVLVLRTSRFFPEEDDDGDRRRAMGDDNLKVLELAYRRCDVEDIVSAAVCAMRRARDVKWAKYIISAPPPFSRDAETLARLDSRPEDVFRSVAPGVDEVFGARGWKHLARVDRVYDSGKAVRELGWRPKWTFVETMERLARGEAWRSELTDRVGKRGYHAVSTGVYTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ35</accession>
    <name>A0A7D5YZ35_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DeSI-like protein sdu1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdu1</name>
        <name evidence="6" type="ORF">G6M90_00g110390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543820.1">
        <property type="nucleotide sequence ID" value="XM_014688334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ35"/>
    <dbReference type="GeneID" id="26243207"/>
    <dbReference type="KEGG" id="mbrn:26243207"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="246" mass="26981" checksum="7A3AF10251920EE7" modified="2021-02-10" version="1">MSTPRQSTGQSGSRHRSTLSLQKTEVTIHVYDLLPPGRLSSVLWTIGASLLHSGVVICGKEYAYGGHDKRGVTGVYWTKPKTEPPGGTFRCEILQGFTLATQDEIDTALRAASEEFLGTSYNLLTKNCNHFTSFLCQKLTGNAGPAWLNRAASIGVALPCVVPREWIEPPEYETADGELLDDDEDVADESSRMLSRAEPHFLSERDDASVEWDSEDERRRGGSGKGKRVVRDSSGRSLPAAERAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZJ5</accession>
    <name>A0A7D5YZJ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PEX12</name>
        <name evidence="19" type="ORF">G6M90_00g022450</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548309.1">
        <property type="nucleotide sequence ID" value="XM_014692823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZJ5"/>
    <dbReference type="GeneID" id="26237753"/>
    <dbReference type="KEGG" id="mbrn:26237753"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Pex N-terminal" evidence="18">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="426" mass="48314" checksum="5A70D52F90B9BD13" modified="2021-02-10" version="1">MEFVTALRGTFDDNKPSLFEVLSEQQLNGLLPPTLRYLLTVATQRHPRYLLRILNSFDELYALCMLAVERHYLRTRGGSFTENFYGLKREKALRGEIPRASISAPNLVRETLKLSTSDVWKNLAVLVGVPYLKRKLDESYEINAPRALLGSAYTRMPDNPTVKDRILHYYRWFLMNIYPSVNAAYYFAILVFNLGYLFDRTKYHNPLMWLIGTRLRRMTGADYQAIDALSQPKPGNRPGSRSIFSPSELGSKVLSSLSLLLPMSIFALKFLEWWHQSDFAKQLSRKATENIDLPPPIVNGVAKKSKSSEGQEDKAEKTEEDGHDKIMSAEDAPIATPSMLPIYVVPTPKDTSHCPICQDDIVTPTACQTGVVYCYTCIHKWLEGTHDKQESFMEKHKGKWESGIGRCAVTGKRVLGGTEGLRRIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZW6</accession>
    <name>A0A7D5YZW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g038290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547187.1">
        <property type="nucleotide sequence ID" value="XM_014691701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZW6"/>
    <dbReference type="GeneID" id="26239750"/>
    <dbReference type="KEGG" id="mbrn:26239750"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="2">
        <location>
            <begin position="787"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="981" mass="111959" checksum="7C0B6FE0D9E04EEB" modified="2021-02-10" version="1">MFEQPVVTFESGQGFSLIGADILIDPDEFEGVHIAAKNLSKDFTRVTGQGGNAVLTTATGRVESKSCVIVGTLSKSAIIKKLGSDGKIDFSGIDGKWESWVTQCVSNPTEGYDNALVIAGSDKRGAIYGIYSLSEQIGVSPWHWWADVPPKVHDEIYALPVSTRNGEPSVKYRGIFINDEAPGMDSWVHEKFGPKFDSNFYHLVFELLLRLKANFMWPAMWRGYPYPGRSFFVDDPKNQALADSYGIVMGTSHHEPMQRAMNEWSTTQPENTWNWEINKEKVTEYFKFGAERARPFESYITMGMRAEGDNPISGSDPKKILTEVLDVQRGIIEENYGSKGGVMQLMALYNEVQQYYDDGLEIPEDITLLFSDDNFGSLRRLPNEQEKKRPGGSGYYYHFQYTGYPRCYRWMNSNTLGKAWHQLQLAHAEGANRIWVFNVGDLKPCEVPMSFGFDLAWNVHSISADSFPQYYEELATREFGRKHAKGIAKAWYDFDRLVALRKQDHIDVNTFILLKYHEADNIVARWKTLLQDAKTINAKIDKEYKSAFFQLVLHPIKASYLCTLLRVTQYRNQLFAKQRRNTTNVLFHRSLEILNKDHDLMMEYHTINGGKWNHIMRQPHYGYGDTGAQPSRNMIDGLCYVQTREDSNPSVGHMGIAVEGIEGINPGHINEDSDRTHPSRKWLEPGVTLPFITPYGPQDRYFEVFHRGTKAFSWVAKPQYDWIKLTQYQGHLKPEDDDTRVVLTIDWTQVPANFDEKVFIEVFGSRDGYEKVHLTVRHSRVPADFTGFVETSGHLAIDAGKWATSPYQALPALGRTAAGSVTLPIGTDLSNPDDIPFLRYPIYVLSDRDNANLELQFNMTLETDPQSRMEYDIRWDGGEIKRYRLTDDDPGNDRGLPRDWNVAVMDCVWKKSHNIGHATVGAHTIEVRFRKPNMILEKLVLDLGDLRYTYLGPPESEYVEGGSRAATCIRHNDRLSLDLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z068</accession>
    <name>A0A7D5Z068_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539966.1">
        <property type="nucleotide sequence ID" value="XM_014684480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z068"/>
    <dbReference type="GeneID" id="26247186"/>
    <dbReference type="KEGG" id="mbrn:26247186"/>
    <dbReference type="OrthoDB" id="4305573at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56427" checksum="15B440BDFF218308" modified="2021-02-10" version="1">MGFVILSKSDKEWEHYRLAFEACAMASFINETGGQLEYKSLTIETYSKALMAMHSALQDPDVVCEDATLAAVLLLALFECLNPTTGGQESWRNYVQGAIELVRGRGRKQTDTRIGQMLFRATRPLMVIYSLATLEDEKEKELWWSGDDECTSTQKLCIGVASLSAKATVLLGPSGHKEEVELEVMLKRCQAHDRACEARWEELSKSTQGISSDNTDPWLLMLLNMLTCARIFLNSIIMRCATWTYKVPNYQTSEEYDGACSALTEIILHSAKVNEQQLCRAEEAQSSFAELDVQLQPGRDSSRCAINKWIEDNRNLWEEKPLVGLQPLAVIWSLECLNDDQKMAIDTQLQRIVGCTVDQIRRSPSYTTEACTRPSPSLSEPATDTPEAGSRDSSPASTGRFRYTQEDDDTLLELSNEGIPWREIRDRFPKHPDSSLKTRLWTLRNCQLTADEDRLLIRLKEEENCSFRDIAPKMRRHRALVSNRYNQLRRNRAMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0A0</accession>
    <name>A0A7D5Z0A0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MYH10</name>
        <name evidence="14" type="ORF">G6M90_00g060630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544632.1">
        <property type="nucleotide sequence ID" value="XM_014689146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243044"/>
    <dbReference type="KEGG" id="mbrn:26243044"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="173"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1680"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1736"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2253"/>
            <end position="2274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2360"/>
            <end position="2389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1287"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1559"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1839"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1944"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1680"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2373"/>
            <end position="2382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="266"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI69105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2389" mass="273143" checksum="FFD6479E4EA92D77" modified="2021-02-10" version="1">MAFNLNNSAQRRSNPFTRTGSPSPSSPTPLNRSRPKSALFSSPPPPPSVSTPSPHGRSQSNSSYGTSLVATGNAVRHHRNESRNGTPTSNTFAPSFIKLEEMRREHDTVKGIEGENDFSGKRYVWVRDSQHAFIKGWVVEELGNSRILVQTDDGTQRELDAESVDKVNPAKFDKANDMAELTHLNEASVVHNLKMRYQSDLIYTYSGLFLVTVNPYCPLPIYTNEYINMYKGRSREDTKPHIFAMADEAFRNLVEEGRNQSILVTGESGAGKTENTKKVIQYLAAVAPSETSARSKSQHTNLSQQILRANPILEAFGNAQTVRNHNSSRFGKFIRIEFNRNGAIAGAFIDWYLLEKSRVVHINPHERNYHIFYQLLKGSSNRVKSDLLLSGLDTQNFAYTRNGHDTIVGVSDKAEWDLLMEAFDVMGFSDDEQLSILRTVAAVLHLGNVEVVKESRAADQARLAPESKQVVTTVCKLLGVPVDPFIQGLLHPKVKAGREWVEKVQTPEQVRLSLDALSKGIYERGFGDLVSRINRQLDRTGMGLDDSHFIGVLDIAGFEIFEENSFEQLCINYTNEKLQQFFNHHMFVLEQEEYAREQIEWQFIDFGRDLQPTIDLIELPNPIGIFSCLDEDCVMPKATDKTFTEKLHSLWDKKSTKYRPSRLGHGFILTHYAAEVEYSTEGWLEKNKDPLNDNITRLLASSSDKHVAGLFSDCAAADEDIGGSRSRVKKGLFRTVAQRHKEQLHSLMTQLHSTHPHFVRCILPNHKKRPKQFNNLLVLDQLRCNGVLEGIRIARTGFPNRLPFTEFRQRYEVLCSNMPTGYLEGQAAATIMLEKLGLDKTLYRVGLTKVFFRAGVLAELEEQRDALITEIMARFQSVARGFIQRRVAYKRLFRTEATRIIQRNFNIYLRLVENPWWQLIVKMKPLLGATRTATEVKKRDAMIKQLNEKMRLDEKVRQKLEDDRRNTHTEMVRIQQTLESERALALDKEEIFKRLQTREAELEEKLSGAIDDQERLEDQLDELMEAKSRAEEDVEKFRHQLEQAAGLIAKLEEEKSKLSAKSVELENAVKEISRKQSERSEQEAALADEIKVLQSQLSVKDRKVQDLEGKLLQLDQDTEVKLRAAQKESEAAKLRETRLSQENKDVKHQLSQLSKTSTDYEDLVRSKESELALLRSDKRKFETERRTLEDQKKALTEEKNRISSRSHDVQAELDAMKSKHSQLEREAEEAKTLLAARLSEDAQADKNRSLLEAQIKDLKEQLYTTQMDLSRERQSRDDVLLLGEHKYQSLKDEYDSLNEAKIVIEKELYVQQDTLRRAMEARTAVEKERDEARDEIRRLRVAKTQAEEARVQAEISGERQASKMALEREVSLRKDLDAAHDRLRWFEDECAKLNHEIEDLNKLIASSGEFGLKNDQAKERMERELNTVKSRLAASENDNRALLNKLQQKGLEIARSTSRANEASRGHIISLQKEKSRLEEQNANLNKQLGDAQVTVATLEKKTEKLQLNLEDLNHEVAREVQSSRNAEKASSNFTVQLAEANRTIDSERQLRTQSQATVRTLQATIDARDKELQELRGQMLNALRSVDPEIRIPPPSDDSNQKALLKNFDLARKVEELQQNLRVQSAARTNAESQLADLRATRHESPGRPKLEEIHLNEAPFNGSPTQRRAAKINARRFSNTSTPRKANQDITEQHDTARSDKTVDTLAVNNRMDLKAEVEELQNQLQITQMQNRHLQSQIDRGTPGPDSYNDQSPSLRRMQKLEKVNSRLHDMLDDSTKKVSALEKNIRTGELSLRDVQARSHEEILDVFNSQEESRRALLHSHKDAVAELTDVKSHFDKMRHERAKLEVELRDTKSDLQEMAMAREQEAQSRSQLLQEYTELQIRLDAETSKLADVSGSLEVYKSRADEYFGKLEQAEIAVLKASRAEQFAKSQAKESEDTYSEVMAERQKMDATIEDLQRQNQRLEERIEDISTDLESVTQAKKRLQHELEDYRSQRAMDIEDKESSMEQTRKKYQAEFTTLTKELDLAREEKLYKQAEIARLREELDELRSKWDDEVLNSSTWSKEKSRLEATLADVASSRDEAVNAHNEAQGKVVSLLSQVRTLRSSVDEVTSERDLLLREKRSVEARLAEAKAGLEELVKGESPSLRDAAILDKEVLDLKSSLAHQEDVAAAAVEKMRRAEALVSDVQKEIAAEREASTELQKQKAALEKSLSEAQLKLIDLETKGFSSASQDIKFLHKRIQELESQLEDHETERSKSQRSNRNIDRTVKDLQSQIDRKEKQNTQLSEDVNRMRDKVDKLLKTIDELQASESTTQLSARRAERELREEKEKALRLEKELEGWKGLRSEKASAVGSLRGRLDGPDVPNRSSSINRAPSLTKGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0T4</accession>
    <name>A0A7D5Z0T4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CHS6</name>
        <name evidence="16" type="ORF">G6M90_00g007410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549769.1">
        <property type="nucleotide sequence ID" value="XM_014694283.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239213"/>
    <dbReference type="KEGG" id="mbrn:26239213"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
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        <location>
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</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">4556</strain>
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</entry>
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    <accession>A0A7D5Z2K1</accession>
    <name>A0A7D5Z2K1_9HYPO</name>
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        </submittedName>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="193"/>
        </location>
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            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI72264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="240" mass="27599" checksum="DEF51CF7DEE46CDD" modified="2021-02-10" version="1">MKPNNEHHATFAEALKNLVAKNLGGVLFLKAYDDPHHSALSFLDGYFRGLLANIETDDPLPVVRIAERVHVMHGTEVYQCINRALLDSIHLLKGLKRRADGALEGEELEEGELEDWEDPELRAIRKYLFQGFIDRLRNDSDELLSNIFYQFAHGVPRQIRTLKRTLEQKQEQKDSETTYTAPQTSFTPEHSIDLQGEPDVVGMLFDEIRKLRPNVDPSRPRLAVLISNPAYLRKFANRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2L8</accession>
    <name>A0A7D5Z2L8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ABP1</name>
        <name evidence="5" type="ORF">G6M90_00g089880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">4556</strain>
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        <location>
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            <end position="185"/>
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            <dbReference type="PROSITE" id="PS50002"/>
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        <source>
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        <source>
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</entry>
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                <person name="Kouvelis V.N."/>
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            <strain evidence="3 4">4556</strain>
        </source>
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    </evidence>
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</entry>
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                <person name="Kortsinoglou A."/>
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            <strain evidence="2 3">4556</strain>
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        </source>
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</entry>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4H7</accession>
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        <recommendedName>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI68967.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26050" checksum="6EC534E75B79762F" modified="2021-02-10" version="1">MESLSATAYAPPPENAMAGVPAHIVDLLDQLHAESWDQESKITRDDFKDRTLHEVMRDKFIALDQDKAQYVYALCRATGARTIVEAGTSFGVSTIYLALAAAANASGGGKPARVIATEHEPTKAARAREIWDKCGEQVVDVIDLREGDLRETLKEDLEDVDLLLLDIWTPMVLPTLQVVLPKMRPGAVVISDNTISSAEGYKDFLEYMRGPQSPFINLTLPYKNGLEMSIYVPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z503</accession>
    <name>A0A7D5Z503_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnr-2</name>
        <name evidence="10" type="ORF">G6M90_00g088140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542301.1">
        <property type="nucleotide sequence ID" value="XM_014686815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z503"/>
    <dbReference type="GeneID" id="26244815"/>
    <dbReference type="KEGG" id="mbrn:26244815"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="413" mass="46724" checksum="61668538CC2E771A" modified="2021-02-10" version="1">MTTQITPSKQAASAIDSLKMESPVKKLDFGVADKENKPLDEAAVAALAEQVDAEHESKIESKKDDKSAAVAPGIKAEVDEPLLQENPQRFVLFPIKYHEIWQMYKKAEASFWTAEEIDLSKDLHDWNNRLNDDEKYFISHILAFFAASDGIVNENLVERFSGEVQIPEARCFYGFQIMMENIHSETYSLLIDTYIKENAQRTYLFNAIDTIPCIRKKADWAIRWIQDKESTFAQRLVAFAAVEGIFFSGAFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLHSHLKNRASKQVIYDIITDAVAIEQEFLTEALPCALLGMNSNLMKQYIEFVADRLLVALGNEKVYKTSNPFDFMENISLGGKTNFFEKRVGDYQKAGVLASASKKEDGTVSDENKDGGDFTFDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z564</accession>
    <name>A0A7D5Z564_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Superkiller protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ski3</name>
        <name evidence="5" type="ORF">G6M90_00g043560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547690.1">
        <property type="nucleotide sequence ID" value="XM_014692204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240253"/>
    <dbReference type="KEGG" id="mbrn:26240253"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1422" mass="158530" checksum="A84313B3E934E2ED" modified="2021-02-10" version="1">MSGAKATLKAINDAIRGQDYDGAIEKAKELIKKDPKSYHGLIFLAFALDKKNQLVEAENFYKKATELRPQDAQAFQGLIKVYEKQGNQRLGEYQTAVVSLAQIFHEAEDLYKAQDVVDKFVDFARVNGDKLQYADALWIQLPESPLYPILEGRFPQPARTYETIAHILEDFEKKRINTLVGERRTRLGARLSEVKVEVKREVYAQSKLEPIYRQLINWTSNDEVRRDFEEKLLQYCYDRLLVTAAGPVKTQEQAKVFGLANDMVTIKHPFKLAWDIAIDWQDGKDIKDWDAGLLRDYCTFFPDSDMYKIITAFLTSNFSPFPPEAKAAEDTRAAANSASDDSEDDEDGGVPIAYVPLTDEDRLMMISEGITGSESVFAYRLVGVYFLQIGEYENTVELMRKARAFLDKERARVGISYENTGDTYALCLATSLVYFQSPRHHQEAKELFEKVLERDSTSTSALIGVGLIFEEEKEYDQAIDFLERALKRDTSNLRVKSEAAWVKALKGDWKTAKHELSECLPILEEKIALYKELMADTQYRIGCCIWNLDTSRQARKQRKGDCAYAYWLSALNNNMNHAPAYTSLGIFYSDYAKDKKRARRCFQKALELSAAEVVSAERLARSFAEDGDWERVELVAQRIIDSGIVKPPPGSKRKGISWPFAAMGVAELNKQDFHKAIVSFQAALRLFPNDYHSWVGLGESYHSSGRYIAATKAIVNAQRLEEHLGDGISADTWFTKYMLANIKRELGEYDESIALYNTVIETHPEEQGVVIALMQTMVDNALTCIEKGLFGKAVQLATYTIEFGSKTPADVKETFNFWKSIADAASVFGSVQSRVVNFPASEIKELLEASYQEAFELLANVDKVGTDVVYAKGIYPKDEQLGVDMTRCIHATILCYKEAIHVSSGDIHAQAVAHYNLGWAEYRAHACLPAQMRKKPSNYIKAAVRALKRAIELESGNADFWNALGVVTSEINPAVSQHAFVRSLHLNERSPVGWTNLGVLALLSGDTKLANEAFTRGQSADPEYAHAWLGQAFLALLYGDVKEARGLFTHAMEIAEASSVPTRKHYSSSLFDHILTAPANMTVASLIQPLFALNQIRSMLPQDLASGHLSCLFNERTRDSASAVKTLEKLCDVIEADYEATESRESLARFTLARTDLARAYLAAGEYAKAVECGEMALGLSSDDADSELTGEQRKKARLSSHLTVGLGQYYLGQHQEAETYFEEALGESDNNPDATCLLAQVLWAQGTEKSRDKAREVLFEVIERQPDHVQSILSLGVVALLDQDESSLEAVVEELQGLRTNDKVSTTEQSQIGEVLRAVAGMAEGHTQQEVVQQIQEDIMLYPHLPHGWSSLAEATGDKYAAQMALKVAARGIPPRGILEAQDLAKAYAGTGKAADAQKAAFLSPWDGCGWTALKVVTDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6U2</accession>
    <name>A0A7D5Z6U2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g068350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987003.1">
        <property type="nucleotide sequence ID" value="XM_066130868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6U2"/>
    <dbReference type="GeneID" id="26246697"/>
    <dbReference type="KEGG" id="mbrn:26246697"/>
    <dbReference type="OrthoDB" id="5151059at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="323" mass="37203" checksum="5FCE4348BF7C7C39" modified="2021-02-10" version="1">MADATLKRLEEELEKIRQDLWDVDSSDDALDKVLAKITSLKAQFEVQKSLQVTANLLRRQPKDRALPKQQATKVKHLIRFVFRKDSRGGDRSQQLRQLDCDSLKLCGLTYTTEDIVKMEHEKFELVRTLAAEFMLNRQLSPLLYRPDVDKAVDAVVEEPDDQESYDAFMKGTTFGSLHRLRLITLEHTSRRLLTRKRKYNAFASPNEDHQGGYNGGRTIDNIDAPANSELHDAANQGTTERATSNKYKGGVFIVRKEDARYAMSLDQHIWEIWLTNPEQRYNTYDGKKRSFLTLWVSEEMGKELGKRGKLMVANEDTNGYLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7V3</accession>
    <name>A0A7D5Z7V3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g073070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545755.1">
        <property type="nucleotide sequence ID" value="XM_014690269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7V3"/>
    <dbReference type="GeneID" id="26241788"/>
    <dbReference type="KEGG" id="mbrn:26241788"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="37718" checksum="63BBBCF36DFEDE78" modified="2021-02-10" version="1">MKSNLDLVHNTDTFPYPPYATGSSTLFDVPNGIYTFVWRDANGIYPVGYVLDRVVAELATVPDDVRGVMEVNHIKKTLSLFQLPSEPERTAMAASLSAHWRDHRTFKLLRGWRGELWPVYGRNGELLFSMERAAIGLLGTMRYGVHLTAYVVEPSAPHGMLIWVPKRAANKSTFPGMLDNTVAGGLMTGETPFECIIREADEEASLIEDVVRPNAEEVGTVTYIYVTDEKNFGQADFIYPECQWVYDLKLPARVIPQPKDGEVEEFKLCDVNQVKRDLACGKFKDNCAVVMLDFFIRHGILMEDEEPHLSTIRSRMHRKLPFPGPHQEGWPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z995</accession>
    <name>A0A7D5Z995_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VRG4_1</name>
        <name evidence="9" type="ORF">G6M90_00g057890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986892.1">
        <property type="nucleotide sequence ID" value="XM_066130651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z995"/>
    <dbReference type="GeneID" id="26242781"/>
    <dbReference type="KEGG" id="mbrn:26242781"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="40216" checksum="775893B1CC8D9B54" modified="2021-02-10" version="1">MGDKKNEDFVVQISDRGFAGNEKEAFTTKATPSGTRGQNEFSQSLSKLDNSPPLSVVAYCFSSISMTVVNKYVVSGTFWNLNFFYLAIQAVVCIAAISVCKSLGLIQNLAPFDRNKARKWFPISLLLVGMIYTSTKALQFLSVPVYTIFKNLTIIVIAYGEVLWFGGSVTPLALLSFGLMVLSSVVAAWADIQSAIAGDFGHADSSAAMSTLNAGYAWMGLNVFCTASYVLGMRKVIKKMNFKDWDKDWSGTNFAKNFPDESRNRIIIGMVYSGLAAIFISYCSAWCIRVTSSTTYSMVGALNKLPIAISGLVFFAAPVTFGSVSAIVIGFVSGIVYAWARVRQSSGSKDSLPTSRPPMSASSQSSRDAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAC6</accession>
    <name>A0A7D5ZAC6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fluconazole resistance protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FCR1</name>
        <name evidence="4" type="ORF">G6M90_00g068870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540006.2">
        <property type="nucleotide sequence ID" value="XM_014684520.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAC6"/>
    <dbReference type="GeneID" id="26247226"/>
    <dbReference type="KEGG" id="mbrn:26247226"/>
    <dbReference type="OrthoDB" id="5098081at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="312" mass="34555" checksum="317D99EAABE176C4" modified="2021-02-10" version="1">MAHEKTGFHMHRSSLPTAKMRTLIPGEEQPKSQTSNESQGGTSSLLRRPRYDRVRAACERCRVKKSKCDNGRPCSRCKDDGVFCTTSTGKKKEYKQPPPGYAEILENNHYTLIATIYKLYDMVRSNQSWDRQEPDLNQEGQPVIHTIARLLGCARRVDDTISVGASLPETESDMVDLACQLLHHQRSQGQSPPATDADGSLPSSLDSPPYEPTSQTTFLDTAACVATVPTPSFAENSDEDSRTPSRNLQVNGPYGTCITPELFLTGSVFQDWGAGLEPCNIEQYGAREIFDDDSMSQGDPIEWQSFLLSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAG7</accession>
    <name>A0A7D5ZAG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase proenzyme 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psd1</name>
        <name evidence="4" type="ORF">G6M90_00g104980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541487.1">
        <property type="nucleotide sequence ID" value="XM_014686001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAG7"/>
    <dbReference type="GeneID" id="26245737"/>
    <dbReference type="KEGG" id="mbrn:26245737"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="410" mass="46457" checksum="29624C7EB94F1CA7" modified="2021-02-10" version="1">MSHNAPTSGHEKLVQELLDMIKAKKWENDFASGIERAIAAAPVDLEKAHIKKGATNDETINYFLDFCDRYLRWVPYTTSARDEPLWVLSLFYFVFHQKGIIEKQTPIEPKYIGQHTELSLWLQKYARTLGTWMDTAASADIVSSFSENPEYTVYQYEKPTGGWNSYNAFFTRKVNPVYRPVAPNNTVASPCDAKFDGFWPITSDGVVELKGLKWPIQQLLKDIPADLVNKFHNGIFMHSFLLPNNYHRVHAPVSGTVKHREKIPGDVYLEVTADSETGKLLLPPRRMEPMPYKDRDGKRQIDAQNHPGYQWNQVRGLWLIDTTGSKDIDIGHVALFAVGMAQISSVQWDDTGKPNTQVKKGDELGMVSYGGSDYILMFEPGKVHFSSERGNESPKKDVLYLQGAALVNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBD0</accession>
    <name>A0A7D5ZBD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g104170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541413.1">
        <property type="nucleotide sequence ID" value="XM_014685927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBD0"/>
    <dbReference type="GeneID" id="26245663"/>
    <dbReference type="KEGG" id="mbrn:26245663"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="594" mass="67473" checksum="9D60993DB60CD77E" modified="2021-02-10" version="1">MDPDTSFGAIGDGSRRPRKLVLCFDGTGDKFHGDDSDSNILKIFRMLDRSSSDQYHYYQPGIGTYAISTSLTNSGYRARFNSWYQKTKDSAVGTSFDQHVVGGYRFLMRFYNSGDEIYIFGFSRGAYIARFLAQMLDHIGLLSHGNEEMVRFAWKAFSQWQSRPQSKDFEGREKVEAEFKTNKMYEYMKGFRETFSRPVGRIRFLGLFDTVNSVPRFETSWMQRSKFPYTARSSAKVIRHAVSIDERRAKFRQDLMYQHKPGGSPHRHQIEQWLDQFRQSHEDRPLEQSSIAKSATNGNTQHHDVRPDDQSRPSEKPADSSHYTSYRPRSQTQEVRLSEDDRAHLIGSEASPGDGDDQQDIDEVWFAGCHGDVGGGWEALDDRKSASHVPLAWIVREAMKAGLLFDMEKVADMECCIEPVDVQPRRPNPAIRVQGESDAAQADVPEINEKDGGLQDVMHKAHTSRLHDCLQYGGGLGSMAVTAWKLMEYLPFRRMDLQPNGSWKPIRWPLPRGEVRDIPDGVRVHGSVIRRLNEVESYRPGNLIMGGGGRGKRRAPKEYGIGDWVCVDEPGDAIGEIWVKRGHSGKQTDSRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBY0</accession>
    <name>A0A7D5ZBY0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g107730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544070.1">
        <property type="nucleotide sequence ID" value="XM_014688584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBY0"/>
    <dbReference type="GeneID" id="26243457"/>
    <dbReference type="KEGG" id="mbrn:26243457"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="205" mass="23921" checksum="9F06F99C3B09B3D6" modified="2021-02-10" version="1">MTREITKDDLAAAARVRPFCAVHFLIDGKTVVKTGENTRLAEANTMRFIRENTNIPVPEVYDAYTHDETGHRHDQYFDDDIGGYGPYSTEEGFNQGLVRAWTKGREDDNFIRFLCKTLLHTMQGHEFVMTHNDFAPRNILVRGSQVVAILDWELSGYFPEYWEFAKALWRPAWDSPWMKDDLVERVLDPYYQQASLILNTSYTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC61</accession>
    <name>A0A7D5ZC61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g112540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987882.1">
        <property type="nucleotide sequence ID" value="XM_066131860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC61"/>
    <dbReference type="GeneID" id="26246916"/>
    <dbReference type="KEGG" id="mbrn:26246916"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="373" mass="41793" checksum="A2BA7ECB4F812FC5" modified="2021-02-10" version="1">MARDFPESEEAAYWRRVNTAVPLTFAALATVAYALRVYATLVLARRVRVEDFFMGCAVLLMIGNTASVLLKAFNGIGVPDKDLPHYRQVNFKLGSWLVIKFWSASMIFAKLAIILFLRRVTGVNRTARAALDTLAVLVVIWGASNFFYTTWFCKPVAYYWDRTIEGGWCVDNDLYMIESKIIASTAVAMDVAMLSIPIPTIWHLQIRLRQKIAITFILCIGVVVCVFSLLRAVQFSQFDTANLSTSSILEGLWTVLENYFTVLCGCLPQLGPLFRRSTKEKEMSTGPGSGYLGSYDASKNIRSWGFQKMSAIETSVCGAHDAPVQARYNSSKEQHNSSELELKGIEVQTTINQEISIGMRSDDEFHIPLDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC67</accession>
    <name>A0A7D5ZC67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g083700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987509.1">
        <property type="nucleotide sequence ID" value="XM_066131234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC67"/>
    <dbReference type="GeneID" id="90968074"/>
    <dbReference type="KEGG" id="mbrn:90968074"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="301" mass="34051" checksum="EC3498223C4826EE" modified="2021-02-10" version="1">MSGCLSVLERWAAEIKLCGAEEVTLQALANSLKLAEGTLNILIVMIEPCNNHATVDYETMVARSPSLQELDRLIRKYGTNRGIAAVPILDVRPLISKAMGTAIGNRWPTWEVRAYEVFEDILRHKKPDVILSLQRVTKDADSLPCKSLSDQAWSPRPDIVRLANRTAILFRAFHPSSYLRPNYTANKATARVNSMENKLDASFKAAFMALNGHQSEVSPWQYHCMLAAERRQEDRSYARRITPSELYCTLQFHDNPETRLALLHEIDIQFKLEELAGTMQPVCREDTTPQEVVELLNSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZE85</accession>
    <name>A0A7D5ZE85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g110810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543779.1">
        <property type="nucleotide sequence ID" value="XM_014688293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZE85"/>
    <dbReference type="GeneID" id="26243166"/>
    <dbReference type="KEGG" id="mbrn:26243166"/>
    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028863034" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="29091" checksum="9D85FB11E37A035F" modified="2021-02-10" version="1">MVASRVLSLALLAALCSAQNLCADINTSDSSPSADIYQSSGKCTSTCKGKYAYAVMQSSNCWCTNYTPDKASQKDGCSLPCPGYPFDMCGGKSRYSYVLVDASLIAGTKGSSSSSSSSSSASSTPSSASDSASSSASSTPAPSASPQVTTVDGVARTVTVMPTQTGDTDSSGSNSNDSGIKVPTLLGIVFGCIGGVAIIAIGIIWFFFRRKQDDKDSDAAASVSTPGRSGGTSRSSLDNLSNPFSDSRSHGLYSWRNRSGSLEFLPEKDTTPTLRVANPDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UP94</accession>
    <name>A0A7D5UP94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abscission/NoCut checkpoint regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Zfyve19</name>
        <name evidence="2" type="ORF">G6M90_00g027360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547851.1">
        <property type="nucleotide sequence ID" value="XM_014692365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UP94"/>
    <dbReference type="GeneID" id="26237295"/>
    <dbReference type="KEGG" id="mbrn:26237295"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="347" mass="37503" checksum="4C3B3FB735B929DD" modified="2021-02-10" version="1">MSDDVDNSLLSRLQALRGEGGSPKIPASNPYGTSPLAHFNSVKMRITNGHSIKFDVIERAKTPTKGDMLAARLKNLRSQADGPISPASAKTTERTTAQTADAPGSKKTPTSEDDVDALFETDDRALEEMLADLDNPDTPEPESKDEHVQALLEQLSAQIPKDSDDNKAKQAANSDDSDGEQMAQEVDDVLARLKDEIQVEAQDGKQRQEPPQGETDIALPSVPANPDLPQDTSPKPRGLDDITARMAALLAPTAQDDLPSVPTSKPSKRVNRLTSRTSYTDDDADSWCTVCLEDATLRCLGCDGDVYCARCWREMHVGPAAAWDERSHKAVQFTRDGGKEGKIALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPL0</accession>
    <name>A0A7D5UPL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g011340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549388.1">
        <property type="nucleotide sequence ID" value="XM_014693902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPL0"/>
    <dbReference type="GeneID" id="26238832"/>
    <dbReference type="KEGG" id="mbrn:26238832"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="407" mass="44133" checksum="F537DABDC65D1522" modified="2021-02-10" version="1">MTSSQSTASQQVPAWKRLGLKLKQPSAATDAASGGTLSVGHPSSTKREAQSNKRKSEAPPATESSHAIKKARKDDQSPPSVDSKTSLKKETKKVTFGHTPTKNGTASATPDSTKPKPASSKKNKGPTKKPPPATPKDIKPALDYLQQWKTAREAWKFNKNFQSLLIDRVFNADDIPAADIATFYEYIRDLKGFVRTRLRETAMEVKAKDIADGPSGFPEGTKEADAKHETYMNLLSDFLSRQHIGKKRKGYDEVEFVASSGAENVIIRRVVKRLRAEIILDELSDGEQTDTSQTTQSSDNTFTTNDNHTLNRADGAKQLKLNDGTAKRRRKIRINADDSSSSESESDSDSGSSSSSSEDSDSSDSDDDDEAVAQEDDGYESSSSSSSSSSSSADESDSDDDSADNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPQ6</accession>
    <name>A0A7D5UPQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g019300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548611.1">
        <property type="nucleotide sequence ID" value="XM_014693125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPQ6"/>
    <dbReference type="GeneID" id="26238055"/>
    <dbReference type="KEGG" id="mbrn:26238055"/>
    <dbReference type="OrthoDB" id="20282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039146">
        <property type="entry name" value="GPANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923">
        <property type="entry name" value="BAT4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20923:SF1">
        <property type="entry name" value="G PATCH DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="24737" checksum="B7DA0F669DD6AC60" modified="2021-02-10" version="1">MRRPRDDSEDDEIPLHHKKPFGSGLKRNKIEFVRATESDDGTAAVSKPRVATAIGDLYASIVLGDGQVNSVSAPATTTASPQPDVCPVCSLPITTSLKEHEASLAHQVSMPHSHPPSALDRSRMGLRALKSQGWDPDARRGLGAEGEGVRYPIKTKAKDDNLGIGAAELLERQKQEAREPPPRKLTGKELKQAMAKEKQRAERLQAEIYGRVDVESYLRRQMDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPY5</accession>
    <name>A0A7D5UPY5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g024690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548113.1">
        <property type="nucleotide sequence ID" value="XM_014692627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPY5"/>
    <dbReference type="GeneID" id="26237557"/>
    <dbReference type="KEGG" id="mbrn:26237557"/>
    <dbReference type="OrthoDB" id="4941540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029001503" evidence="2">
        <location>
            <begin position="17"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="286" mass="31542" checksum="91594E4BE6F5D4C2" modified="2021-02-10" version="1">MKSVSVLLFTAGLVSAVAVPVQLAERAALQPLPGLTAVEEDLEKRGLSFVELMARQEAAQGERPSSAAPAAASTTAAAEAPAETQNNQDQNKDQNKDQNKDQNKDQNKDQNKDQNKDQNKDQNQNQNQDQNKDQNKDNKGQNNNNNNNNKDNNNNNNNNNKDNNNNNNNDQNNNNNNNNNNNNNGNRNDDINQIIQQGLQGNLFQSLLTPSITAIINQMGIGQNFNFGAIQNLGFADQIFLFNQLQLAQGFVQFGVVPRQQVITVLNNGFVSNGINVGIFKRDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ27</accession>
    <name>A0A7D5UQ27_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">twfA</name>
        <name evidence="13" type="ORF">G6M90_00g017420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548788.1">
        <property type="nucleotide sequence ID" value="XM_014693302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ27"/>
    <dbReference type="GeneID" id="26238232"/>
    <dbReference type="KEGG" id="mbrn:26238232"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="12">
        <location>
            <begin position="174"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI63878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="332" mass="36662" checksum="1F510EDDD8214731" modified="2021-02-10" version="1">MQSGISASQELQAEFNSLLSSPSTFGLIVGIEKESLVPLTTLPSQGPSFLENLGSLQSHLEPNVPLYILLRRYDDIPRLTAISYVPDTAHVRQKMLFASTRLALVRELGSEHFRETIFVTTADELSESGFKKHDAHSQLAAPLTEEERTLGEVKRAEQEAGSGTGTREIHLSKSFAMPVAEDAVAALKDLGQDDGRVVAMLKINPESESVELLPESPRPASIAELAKAISTTEPRFTFYRFKHTHNGAEQSPVLFFYTCPLTAGNKSIKKRMLYPLMKRAVLEIAGKEAGLSLEKKFEVEEPSEITEQSVMEDLHPKTTARSGFSRPKRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ49</accession>
    <name>A0A7D5UQ49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g006370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549870.1">
        <property type="nucleotide sequence ID" value="XM_014694384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ49"/>
    <dbReference type="GeneID" id="26239314"/>
    <dbReference type="KEGG" id="mbrn:26239314"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028967859" description="Transcription factor domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55027" checksum="79A0D77FF66B3C92" modified="2021-02-10" version="1">MPPVENLLLLFGIFAAAAFHWSSELLQSLHATRAEAKAAFFEYLRVGVSIIDNTVRPIIPSTNALAAMCNLHNVITHARGLSDNDVALRMKCYSMARTLQIDRLDTAKSREERRQKGCNMIEVEVQRRIWWSLVGSDWLNSFSGGPNDGAYFLQPKHMNVRLPANVDDKDVTADMVEKDIPLTKPSGMSGFIHRVKISQICREVVDALPSQFHDADERSYNTILQMDNKFRTFLEELPVYFRLDPESIERSKDICRERPIIALQRVGVNFSIRIRLCRLHRPYHLEGLTNSTYAFSHKACIQEAQKVLDLRRAMDECGSPLGMNPARSWVVMQHVSIAALILATDVSFNPLARDAEQRKAKVLATCELLEKSMEDSESIMEGVQRNVQVLVSTLQKQRSQSTSRHEPSASLYTASGMEQLRDAAMADADDDTLANFVGSTDRNNGFLDDLNEDQTDWDQLWKDFIAIAPELDVAHWDLLFEDVQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ81</accession>
    <name>A0A7D5UQ81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g025190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548063.2">
        <property type="nucleotide sequence ID" value="XM_014692577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ81"/>
    <dbReference type="GeneID" id="26237507"/>
    <dbReference type="KEGG" id="mbrn:26237507"/>
    <dbReference type="OrthoDB" id="5316527at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="417" mass="46618" checksum="09BA2574E561170E" modified="2021-02-10" version="1">MLPRAAAAFWRASTASSFIVRPNIVRRVPQSTRPLSLWPFKGSKVPHDLPVYFPRPPPAPKSHAFRKRLGRVVFTTITLYVCFQIFATVVFDPLLDWADHEWDNLSDKEKREMEEMAGEEDDPLLFLPFPFTTKEVKQPPYKGSDPEWLAFLAVNKDQQVQKDIKFGLAEIIRRGVEKNPGYVRLLGGKDIKLKKLWLDIIYPPAPPPKHYVSGIIIDDEGIFWGDRPIDSVAASHVNMAIYPKAVALTVWTFVNSLCRQTAQDVAKALGFNTEPPQDTSWQTVAINRMKEQGALGSGGKHAVKVPSTTDKPANFPFPTANGDLFGPSIGSDNTQLDPRIQGALHAASMTFTKNWQPVKQPPSRGCIRVDGLVELQGKNAVMAVYVLGWYDPKQKNYMAIQTGLKHLIQLKQRPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQA8</accession>
    <name>A0A7D5UQA8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CTS2</name>
        <name evidence="14" type="ORF">G6M90_00g002090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542872.1">
        <property type="nucleotide sequence ID" value="XM_014687386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQA8"/>
    <dbReference type="SMR" id="A0A7D5UQA8"/>
    <dbReference type="GeneID" id="26244245"/>
    <dbReference type="KEGG" id="mbrn:26244245"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="40"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="413" mass="45403" checksum="BC4CEF7D7AD95853" modified="2021-02-10" version="1">MGCSFSVLINQYPTTFTNMRFESTLWTALLSYVAPALGANVLVGYYPTWKHAAISNMDLSNYTHVNVAFAIPHENGTLSFEGDTFMDKLVPKLQGAGSKVLVSIGGWSGSANFSSITKDTALSGTLTKSIIDMMTKYKLDGIDIDWEFPGRKGSDCNVVDEQNDATNFLKYLNDLRAKMDEALGKGKLITLALRIQPFDGPGGKDVSGFAKVVDFANLMQYDLNGAWGETSGPLAPLNFEEKKGTQLSFATAIEAWTKAGWPAKQLTAGAAFYGYSVTAAEDMLKTNPPNQYAKMEKERPKGDQEDEMVTEPCSSAPKAYTGIWTYKNLRGQGVLSSPDEAKAPWVRTFDNKTMTPWLFNSESKVFISYDDQRSLAAKVKFAESKGLGGMMVWSIERDYNGELLSELKKFGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQE0</accession>
    <name>A0A7D5UQE0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">nsmce1</name>
        <name evidence="18" type="ORF">G6M90_00g006120</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 15"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549895.1">
        <property type="nucleotide sequence ID" value="XM_014694409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQE0"/>
    <dbReference type="GeneID" id="26239339"/>
    <dbReference type="KEGG" id="mbrn:26239339"/>
    <dbReference type="OrthoDB" id="185455at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="17">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI64294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="338" mass="38698" checksum="8A1C3BE30C03B185" modified="2021-02-10" version="1">MDSVLGPDYENSHRAFLQALLAHSTLTFEEAQPVLAAIFNAAGIHESVVRPEQITEDEFKRYIEVASDAASLFDYEVRSIMHQVTKHRVYALVNTQSDPQTQLATTYSPEELAFIKRVLDGMFDKYNTPRMEVLAITEMQAIKFARPPNRRQSHLDPEDSTETQAQLAAADKGLKHSEVEAVMRSLVEGGWFEKSQDGFYAVTPRVLLELRPWLVETYNDPDAEADEWQRIKFCEACKDIVTIGRRCAQPSCTLRLHDMCQDAFWRARRSKNCPKCQKEWTGDRYIGERAVTMTEAYQKGRRRSGGRKSTLADDVIQQQGMEEDVDEDDDEEDEDDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQI3</accession>
    <name>A0A7D5UQI3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat domain-containing protein 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANKRD50_0</name>
        <name evidence="8" type="ORF">G6M90_00g016610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548869.1">
        <property type="nucleotide sequence ID" value="XM_014693383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238313"/>
    <dbReference type="KEGG" id="mbrn:26238313"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="499"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="6">
        <location>
            <begin position="782"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1110"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1143"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1278"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1312"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1345"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1378"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1412"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1499" mass="166842" checksum="CAF8BB89A5BE7670" modified="2021-02-10" version="1">MPSFPPSRMLAALLVRWHSLAYSILMFGLLFLLTALYFLLSQGASRLQRRLSVRITLAEPGGGTARESDEGNRTPRTSNSVSRQGNVSSQLKSMHVRSEDTPTPAINTQKRKLDPENYTVGWICALRMEHFAACALLDEEHQGPEYVPGVTDIAYTLGRMGQHNVVIVVMPEACSNPASVAARHLSYSFPNIRFGLMVGIGGGAPSRKNDVRLGDIVVSVPRGDSHGVFQYDLGRTMQDGSLHVTSVLNQPPIFLRNAVDRLQFRYEIPGQQLQQTISSILKRNPRLQSFKRPHPSADRLYRAKVTHPPGTARCETSCGTDPMKLVRRNERDPFKSYPAVHYGVIASASQMPRDAFIRDKLVAEKNVICFEMEAAGLMSYFPCLVIRSIYNYADSHNNDEWLQYAAISAAAYAKDLLYQIPIAAVKSQKRISDILKAAENPAKSDADASQAQRIAKQQAARRAWSPEEVQCLQSLRLAGNNENTAYEWYKNRVEDPLEGTCLWFLQQHHFQKWQKQDSGVLLLLAGPGHGKSVLVKYLVDHGLPKTSTICYFFFQKNVQDQVCQALCALLHQLFSQNPALIDHAMLQFRRDKQGLTNSTELLWGILKNAVKDSRGGPIIFVLDALDVCTDSDLRGLAQNIHNHATSDRIGSNKLKYLLTSRPDRPLFPFCNHPSEDSPHITIFEDDTSRFIMDDVTHFVTHRVAQLSRTKDLLNSTKSHLEWILQGKRDSSHLWIRLVFEYLERQNLENSPRTIDIFIAKLPMSVPRVYGVIFDSLESQEQPTALKVLNLILAANRPLTISEVNIAMSLHDTVKSIHDIDLQNEEDLKTRLQSMCGSFISIYKGSIYFRHETAREFLLTDASLTSPIPSEPRHHSTSLMQAHTTLVEACVLYLNLLNADLELPEETIGEANAANPRYAFLDYSAKNWASHFRQANITDNAAVIPRVLKICDSNSRSYAAWFEIYRQTVSAEIPGKLTNLMLASHYGHLPIVDLLLQGSAKIEGDNDKDSRTPLSWAAQSGYEAVARLLLEEGANIEAKDSQSGRTPLSWAAENGHEAVVRLLLDKGANIEAKDSQRGQTPLSWAVENGHEAVVGLLLQKGANIEAKDSRYGRTPLSQAAESGREGLVWLLLHRGADIYTKDKYSQTPLYWAARMGHEAVVQLLLEKGATIEAEHTINGQTPLLWAAENGHEVLTWLLLDQGADIEAINTSGWTPLLLCAKNGHEAVVKLLLERSANIESKDTQDGRTPLSWAAENGHKEVVMLLLKKGAHIEAKDTKDERTPLSWAAERGHGAVVKLLLRGGANVETRDNKHGWTPLAWAAERGHKDIVDLLIDGGSDFEVEDNTGQTPLLLAGRNGYDAIVGRLLSDLAGFDVRDENGRTLLSLAAEKGYENIVRLLLKDGAAVDPTDRETDRTPLSWAAEKGHEEISRLLLDSGADVGLKDFHGQTPLSWAAKTDNKNIVALLQEASELAQRRKEARSSGRAFFWDSQVTSFSNHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR67</accession>
    <name>A0A7D5UR67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gelsolin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Gsn</name>
        <name evidence="4" type="ORF">G6M90_00g016000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548929.1">
        <property type="nucleotide sequence ID" value="XM_014693443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238373"/>
    <dbReference type="KEGG" id="mbrn:26238373"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057226">
        <property type="entry name" value="DUF7904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF133">
        <property type="entry name" value="DUF4045 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="2">
        <location>
            <begin position="2"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7904" evidence="3">
        <location>
            <begin position="1151"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="51"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
            <begin position="154"/>
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        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="273"/>
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        </location>
    </feature>
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        <location>
            <begin position="347"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
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        <location>
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            <begin position="1095"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF13254"/>
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            <dbReference type="Pfam" id="PF25480"/>
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            <dbReference type="EMBL" id="QLI64658.1"/>
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            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
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    <sequence length="1500" mass="162011" checksum="FB11695A869226DF" modified="2021-02-10" version="1">MSDEVSQFLEQVERLRGQQIEDDEARAREREEFLAAKRERQARREERARSISPQKSSPMNTPSPRSSHQSAQVSDATRLGSPSRTLDDREPPASPPAGHDSMTSPGLPAKDSDASAELDTQPTESSTPPARTSTLSWQRRPASRGGARPLSMVAAQNATQRSLAGSQEPASATEETVSKDQIAKALGSKDPSWFRQTADRGQNSAAYRRSQVEDEDRLDMSSVRAQLPGMSLTNPVSSSRSSPSPQPSPEPPSHPGLASPVTFNPPRFDTASAEKQPTQEPASLSGRASPTRSPSPTKGLGGFVQSAMMKRSDSVKRWSVTSPPGLTRADSVAATRGARSSVHMGSRPQSTVRRDSATPTSSRPTSQHGDRPSDLGDISKSSSLMSIDTGRAEEKDEDAGIPSSPSKTMDPRRWSPTKSSWLENALNRPESPKPSPTTAQPTWRNNANAESSRPKSVSHKHQVSIGGLMRQSAVGNVAKSNPTGLGGIYSPPPNANRPAYGQGSKPSTAQQSDPDLPRPDEMTDKEDTKPTDKETSSPSATKHTPVMSPPPLKPKPQTPPTMDFRSNLRQRPAEKDTPKSGEPEFKNVFGNLRKTKTQNYVAPDELKNNILRGKSALNVTDGPKKSERKDEFKDAILKKRADFKAVQSEGRGVTRASSTASERPLPEGLAKRVELSKSVAAMAKKSNVPETPTPTPTKKEDSPKPAPAPKRVPSGSAFSPRSPNTAIPPARSPSTEKLRRVSTEPEAAKTTVEPQATPTLQKEMNAPSKLAAQSRVVGGKLADRFNPGLAGMLARGPPPMATNGGRSSEETGDDNGKPGSGDATEPSAPGPQLTHMTKGRARGPKRKAPTGAAASTLSQTARQLPPAIVEAAKEDEPTVQEVAINKLGTQHVSTGPAGLDEKPITPTIQQEVDTKTTLGNTPSLPPVTLVAKTSEPRESLEPAARPVSRGRPLPLGPRASTPSSPAKPSPQPEEDASSATSPKKFDTKKMSRFLDESPSKDVQRDTAAEPTWLRHKRTGSQSPTKLAEPPSPTKSDRDSLPSMREASPRSPRFGARSIPISKPSFDEPVTPGGGQSRRVRPLSGLSGDGLKSPAAISSPTRSPTKQINEVSALLTEFFGPPQTREAINVDPAQILMNRPDTGDKVTSLGLQMFQILGDGKKLPVSPQNERVLFEQEMYVCAHNFINGSGKKVFEVYFWVGDEVPELSAEDAQLFVQREARSLGGKLVRFQQGKETAEFVQALGGVIIVRRGSSNKYDSLAPNILCGRRYLGQVAFDEVDFAPSSLCTGFTYLITKGGNCYMWKGKGGDVAEVSCARLIGMDLTLTGELIEYEDGNEPTSFWDLFGDNSSKPHSADHWRLKPNYDKYCSRLFCSDADSRQQIFELSPFNQVDLLPTSIYVLDAFFEMYIIVGSRANAQYASFRNALDFAQEYAILASGMEDRPFVPVSTVVLEGIPRDLKRVFRKWDDGRSPTVTNASVGLKRGRSLRIVTLTQALQALRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URD3</accession>
    <name>A0A7D5URD3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g022470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URD3"/>
    <dbReference type="GeneID" id="26237751"/>
    <dbReference type="KEGG" id="mbrn:26237751"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
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        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="323" mass="36886" checksum="F9F830DF0FAFC2EB" modified="2021-02-10" version="1">MGLLVWLGLRRSNQWESLTVMDHLIDSPLTFFTVNFYHLVLFLRGTPFRPPRHQPSIRVVCISDTHDQIVDVPPGDILVHAGDLTNAGTAADIQKQLDWLKTLPHPVKIVIAGNHDSYFDIRSRCDDDRRRGARLNLDGLIYLQGEISAHKIRGREISIFGAPDIPECGPKSFAFQYSPTRPPWLSKVPPQTDILVTHSPPKHHLDLDLGCPHLLREVWRVKPRLHVFGHCHCAYGKESVYFDDVQFAYERLLSRPRRGFFWDFIPNQSWVDMFEIVYHGIHSVLWKWLMSGPGSNQGSLMVNAAQMYKNSGKAVSRAVVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URG7</accession>
    <name>A0A7D5URG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cobalt uptake protein COT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">COT1_0</name>
        <name evidence="12" type="ORF">G6M90_00g022360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692833.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URG7"/>
    <dbReference type="GeneID" id="26237763"/>
    <dbReference type="KEGG" id="mbrn:26237763"/>
    <dbReference type="OrthoDB" id="3540486at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="2EXR" evidence="11">
        <location>
            <begin position="391"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="781" mass="87355" checksum="C1E40F7C3F871D20" modified="2021-02-10" version="1">MAAFTITRKQRLMATIAISAAFFVAELIAGCYTHSLALIADAFHYLSDLVGFVVAFVALTVSEGSQPPPKEFTFGWQRATLLGAFFNGVFLVALGVSILVQAIERFTHTLHIDEPKVVLVVGCVGLGLNLLVMSFLHEHDDHDHGHGDGHSHSHGSHDDAAHFDDEAFMMVDDPENRAESRKVSVTSSHHEHKHSFVAPSKPGRDLGIFGVFIHVVGDAINNVGVIVSAVIIWKLDSPARYYADPAVGIFIAIMIFLTAIPLTKKSGSILLQIAPGGIDVEDVKHDIEMIPGIESVHELHVWRLDQRKTVASAHIVVDDRTVKHFTEKAKIVMECLHAYGIHSATLQPEILPPITEQHVEDVSNARETTVHRRRLNRSAKEYVVYAYMAEFAPFPKLPAEIRLAVWELVQPPPRIIGQVPCRACWAECFAWRRGRDANCSRRRQCEQRNHPDWRVRYIVHPRRDAVFPLLHACQESRAVWLPRFHRPAARHLVCETGVASADEGDQTAGVRFDVPFINYEADILTVFDDWAFAGALNTVDRRPQTEQGELDPFVGLRRESIRHAGFCESAEELWSALLSLDARTLPRLRSLSLVRMGPLPPGQETERSAPGEMMCPALSQGVDCVVRDVAFPGDAYHAFFHHWRSRDELFEPRSELPLFKAFHRFWKAFLWHLLNREARRGFGRDYSGWWTFMEYVGRSGVDAAGSVCVLSKVDGCGAGGHGHEDMLDWTPAFQLRCRLLCEEGEAHGLKALREANAGKVGGISERASLERLLPGEYVSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URJ1</accession>
    <name>A0A7D5URJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tripeptidyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tap_0</name>
        <name evidence="6" type="ORF">G6M90_00g000990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542971.1">
        <property type="nucleotide sequence ID" value="XM_014687485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URJ1"/>
    <dbReference type="GeneID" id="26244344"/>
    <dbReference type="KEGG" id="mbrn:26244344"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="163"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="516"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="636" mass="68445" checksum="EE9C57E43F1B895E" modified="2021-02-10" version="1">MKQADQRAGGNAPGFLTRLAILGIGIAPTLVPSVAASPAAFHYSRQANPANATGEFPKPDDPFHFIPCVSNQTIEGIPLLNDTNPQETWRKRFDPNPNNWKWGAAPGNATTPGSSNSTQGRGLHLCGYLDVPMDYLNKSDPRIHRLAVAKYQASGLEGKGARTIVMNPGGPGGSGVPFGLHGGRYSQILSNGVHDFLGFDPRGVGLSQPAIDCYPAALQDRWNLAAGKDLRESPSPRQQLELVNAVNDAKFKACFEELGDVPRFVSTASVARDVDAIRAALGEPELTGYMVSYGTTLGQIYANMFPDKAGRLILDGVDYSREHRVTGGYASTAIHSTTDAWNEGFLGECVAAGPSSCALAKPTNGSGVTLDSLKARMAKLLDGLAERPIPAYDEEKGPVIITYSLIIAVISSALYQPRYWPEVAQALADLESGNTTIAASMAHGQYVYQPQAPEKPLGLASELLPMVVCGDASADGPPASGLDFWESLWRNLTEKSFLSGGGNFATVFPCQNYNKYWPQGAALYQGDLNNKLKHPVLLIAETHDPVTPLRNARELHKEMGMENARLVVHHGYGHGSSPDPSDCTNAIIRGYLLNGTIPDKRETDCYANGKPYRNSTRTNHKRSLPMVGNVPMRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URL9</accession>
    <name>A0A7D5URL9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g009430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the paxB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549571.1">
        <property type="nucleotide sequence ID" value="XM_014694085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URL9"/>
    <dbReference type="GeneID" id="26239015"/>
    <dbReference type="KEGG" id="mbrn:26239015"/>
    <dbReference type="OrthoDB" id="4938279at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="193" mass="21245" checksum="4B24CEA43804DE5E" modified="2021-02-10" version="1">MGSSDIPPPTAPGWLIPASSALLSAGVVFWLICYVLMTKRSLSTRDTPIPLLALGINLSWELVYAFYVTEEWLEFAGFVMWLALDMPVLYTTLRYGRRSNAASPLVARHVPLLLGLVFAFGLVTNSLFASWWLKEPHRGSGLKSGKVWKGLEARDTTELAWWSAGVAQMIMSVGALGMLLQRGHSGGQSYAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URM0</accession>
    <name>A0A7D5URM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">MRI1</name>
        <name evidence="7" type="ORF">G6M90_00g006550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549852.1">
        <property type="nucleotide sequence ID" value="XM_014694366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URM0"/>
    <dbReference type="GeneID" id="26239296"/>
    <dbReference type="KEGG" id="mbrn:26239296"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="386" mass="41842" checksum="6FE5B254A5C602B3" modified="2021-02-10" version="1">MSTLQAVRYSRGKLEVLDQLRLPHEFHYDQVSTRQEAFDSIASMRTRGAPAIAIVASLGLAVELFNGPVAADSPQQVIAHIDEALDYLKQSRPTAVDLTNAINQLKARIRTSGETKASIIQGFIEEAENIFEKDLKTNLAIGDYGAEWLKTQVGATSDNTVSVLTHCNTGSLATSGHGTALGIIRTLQANGQLRHAFCTETRPYNQGSRLTAFELVYEGIPSTLITDSMAASLFRTKKAEKNIVAVIVGADRVVRNGDTANKIGTYQLAVLAKHHGIKFLVAAPTTSIDLETETGNGIKIEERKREELTQVTGAVIKADGKVDESTKVRVATADQRIEVWNPAFDVTPAELIDAVVTEKGAVEKGPDGKFDFSKIMPERWAKVAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US32</accession>
    <name>A0A7D5US32_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylamine N-acetyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Nat2</name>
        <name evidence="3" type="ORF">G6M90_00g010190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549498.1">
        <property type="nucleotide sequence ID" value="XM_014694012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US32"/>
    <dbReference type="GeneID" id="26238942"/>
    <dbReference type="KEGG" id="mbrn:26238942"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="298" mass="33528" checksum="7A8C8909A7A83E3C" modified="2021-02-10" version="1">MAYTPDQVDRYLQHIDFPASKHPPDALQRLTQLVARQVARVPFESFALHYSQHKRLSLDPEALFEKIVVHGKGGYCMELNAFFGGMMRGLGYRVLNAGGRVKTPAGYTGWSHMVNIVTVGDTRYNVDVGFGSHEPMQPIPLRHNYTFTQIAPREGRLEHRSVSQHTDASQRVWVYSTREDASAPWEERNMFVETEFFRADYEAMNLSTMSAATSFFVQNVIGMRAVLDAAGDVVGVYTLFGARVKRHMRHAEAEVVAELADEDARVRAIDEYFGVKLTALEARGIRGLATELRAKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US87</accession>
    <name>A0A7D5US87_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g012340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549288.1">
        <property type="nucleotide sequence ID" value="XM_014693802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US87"/>
    <dbReference type="GeneID" id="26238732"/>
    <dbReference type="KEGG" id="mbrn:26238732"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="485" mass="53188" checksum="9838AC9E9E8B7FB5" modified="2021-02-10" version="1">MDQLHLTHSLADAFNALADEVQILADRKTVLEHKLRFAHEQFQYLADKYAAGTPEIAETLAKLQLPPHTSVDDTSPVPLPQRRSTPQPLHQIAVIIRDGRRMASKLVALSSSSKTTGSSRETLSRTSQDETSMSTALEQDFTVEGKKGNLQCPFSKRVSVSGTNDGESRPSVDHTPHSSADPICAAMFEEATSQPAPNGTSSKCPIRFMDKHSPEEIAHYVETHKHELPRSHEVCLRRYQRNETQIKKLDSKYGNIVSMIEGLSQLHQPMLPESEEQLQQRDAGDGDSNVRVETWAQAVSGTAESDASEELPPLDEDRQSHFDRPLKEVRVGESPSRPWGISVPIYELSGHEDEHPLSPPPAPVRMSTAVHDHVPPAATNGAGKCPFDHTKFSAGFAGPPPSTPKPEEKPSEPVQGLGLGDTPFTNLKEAPPTTTGPPPQPTFINPASTHAEDSRGPQMVFTGPVFIGYPMDQAIEFMNRYRGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTD1</accession>
    <name>A0A7D5UTD1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnh-201</name>
        <name evidence="11" type="ORF">G6M90_00g050650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545169.2">
        <property type="nucleotide sequence ID" value="XM_014689683.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTD1"/>
    <dbReference type="GeneID" id="26242510"/>
    <dbReference type="KEGG" id="mbrn:26242510"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="54"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="332" mass="35378" checksum="51289D77CF86D247" modified="2021-02-10" version="1">MAEADETPPSPSTFVPPSVHREALLAGSSFTHFSPVPPALLTPARASDPSSLPPLCLGVDEAGRGPVLGPMVYGIFYLPQPQSDPLLRDAHGFDDSKALTAAARSSLMRALCTAGTDLHAQCGWATAALSARDISAGMLRPSGAYNLNAQAMDATVALVRGALERGLNVREVYVDTVGPPATYQARLQRVFPTVKITVAKKADSLYPCVSAASVCAKVTRDAALEVLYEARRDENGAGPGMEWGSGYPSDARCVGWLRRNMHPVFGWGPECRFSWGTAKDMLETKGGVRVDWPVEEEAGDSMRVTDFFAAGRDDETDELGGWYGSPAGLEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTZ4</accession>
    <name>A0A7D5UTZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543170.1">
        <property type="nucleotide sequence ID" value="XM_014687684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTZ4"/>
    <dbReference type="GeneID" id="26243971"/>
    <dbReference type="KEGG" id="mbrn:26243971"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="390" mass="44231" checksum="CE7CA0E43C6CEA72" modified="2021-02-10" version="1">MSGNLSNNGAPVLNWANTDIDKEVALGAVDWDALLQYAQATRQKIEKSEVPLTCQLSVENNKGGRNLVRRLHFQDGACWLVRIQLDDPTPESIQRLEQEVHTMSVVRERSEIPVPEVYAYEANYDNVFGAPFMLMEFLPGDTIMDSFGGYQVHKGKIPENFTPDFHATLADIQVQMSAIRFPQIGGIVKASNGTYCVGPLPGIGGPFDSPAQFLEAWADNLKFPYSEKTIRERTPPQLFDEILESIRSFPSKLKELAREYGFRTGPFPLFHTDLYCSNIVLASQYYVIDWEDSFILPWEMVEFAKNLCMLPPALDGPLYHEDETDRKRLAERENYIKLVRAAEESRGLDHHLSATLANSTVQNFAHAMWLYRIDGRIGFYNDVINSVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU18</accession>
    <name>A0A7D5UU18_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g051070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545205.1">
        <property type="nucleotide sequence ID" value="XM_014689719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU18"/>
    <dbReference type="GeneID" id="26242546"/>
    <dbReference type="KEGG" id="mbrn:26242546"/>
    <dbReference type="OrthoDB" id="4936797at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="859" mass="94191" checksum="1D495E0946D32B16" modified="2021-02-10" version="1">MAFTEQIEILRREIRGMEEFFGGLSVEAVEENSRLTILQWTKRLCERAETMIKNHEDGIKAQQVAALETELQVSESAKARLRSELDRLQRTFDTRLQDQVKAETEAIQARLTERMEKQFDSRLIALATEVRRADAEASPCQIEREKRLDEKEERLNEKERRLAEQGAALTVRETSLQETRDDVNRRSRELVAGRQDQLDRVQTVLDTELSAIKSRLESLDKAVAKNGDVCKLQETLNEQRAALGGLPSRSDVESAVSGLPVLQSLVGAASGLQSAATSQQDRLGELLLSKRETLALLNDAVDAVETKVGLVHEAVEDHDKAVSLQFSAVGDSVDGIGRRLDVEGGLAGQQAIDRLKDGIDGIGRRLEVEGGLAGQQAVDQLKDDVAGLSRVARRLPTASRVTRSLGELKGSPDNQDGFITYDVFVGFARDLASELCAKIPQGSTLLSEEQVHAIVSSVVSGLATVSDLESCGLLDAAHDRVQRRDITDLTAQVSQAIACHDAALGQLRQTASDQGLRRFDFLNLASKVGSIRADLSQRSDVAELKSIVLQNNEARDSECQAQAAELAKLSAKVDGVDSKLANTNLAEKADLVELTDTVRQADSARDKLVQNEDIAVLGDKVEAMSAWLMDSDYPKGAEVARLATRILSQDADREIASQEVCQAVSAMSESLAQHLEVLTNWRGTATPDSLQTALGELSETITSIKQQIDGTSEAVDQISSDLGKLGGPTPPSTTEVGKPQWLHKYQSLRFWDSTIDRLLTSLAILNVVGAENLEPKEVCQLLLDTLQPDNLYLAMRLVDSGPREDWFCFRGICNGEEIEPENGQCPIHGDCILVKRTYFDNEMGEPEIGLKFRKVRKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUG8</accession>
    <name>A0A7D5UUG8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alkyltransferase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atl1</name>
        <name evidence="3" type="ORF">G6M90_00g030290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539741.1">
        <property type="nucleotide sequence ID" value="XM_014684255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUG8"/>
    <dbReference type="GeneID" id="26247498"/>
    <dbReference type="KEGG" id="mbrn:26247498"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16006" checksum="949A4C1536BFA2D5" modified="2021-02-10" version="1">MARSDEAAAFFHAVYSAVQEIPRGKVTSYAHIATLVGTRGVAAQRPRQVGMCMKHLSSDASHRFNNANVPWQRVINSKGVISPRSQPDGAQNQAAALRDEGVHVTRGAMGEFMVDFGEYGWFPRVLPSEAVGDEAWESSTGEEEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUR1</accession>
    <name>A0A7D5UUR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EPD1</name>
        <name evidence="7" type="ORF">G6M90_00g034140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986347.1">
        <property type="nucleotide sequence ID" value="XM_066130141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUR1"/>
    <dbReference type="GeneID" id="26244142"/>
    <dbReference type="KEGG" id="mbrn:26244142"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="459" mass="49803" checksum="1D4F5811FAF061F5" modified="2021-02-10" version="1">MFGLGAFVAALDPVEAYGNKFFTRNGTQFFVKGVAYQLVPDDPLIDTEQCKRDFSLMKELGVNTIRVYHVDAKAKHDGCMRALDDAGIYLLVDMDTFGTYIESKDLYWNSTQYERYSQVMDAFHSYDNVLGFFVGNENIATKDDSPAAPFLKAAARDMKVYRDNKGYRNIPIGYSAADIVQLRPMLQDYLTCGGNSSEIVDFFALNSYSWCDPSTFEASSYDKLQEYAKNFPVPIFFSETGCNVPGPRKWDDQDAIFAKPMVDDWSGAIIYEWIEEQNHYGLISYGPKGDASQPGENVFDGFTRKGTPTPISPDFDNLKTKWASMQPTGVVKNDYDPKQVSTRPCPTSTADGWWQVNGNVELPTLGETLTGTFTSQASTTASPSEKPKPSNSGNRGQGGGNSGGSGSGSGSGSDNDGDGDRNGSGGGKKDEDNAASPDRHLAAAGASIAAAVLVLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVP4</accession>
    <name>A0A7D5UVP4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g051970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986539.1">
        <property type="nucleotide sequence ID" value="XM_066130522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVP4"/>
    <dbReference type="GeneID" id="90967765"/>
    <dbReference type="KEGG" id="mbrn:90967765"/>
    <dbReference type="OrthoDB" id="4956439at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="289" mass="31737" checksum="51288852C610AFE1" modified="2021-02-10" version="1">MSGSGNSPSVSSSSKESAADKACKLANRVILAQIQTKLKRNPTTNLSPFLRQQSESYDEFVANLAAAQNAESDSEDEDCPDLSNELCGLVLGGSPEIIHALHDRVLKLSSGGVTTFNLDNSKNLPMDIVAGLNEAIQGGEVLWRLHDTFVIGLGSSEVVKISTSLDLDEISNLEYLNSLSLGIPIPLCLGALRSGRRVYLFMSRASGQPLEMVWPQLTPLHKTSIQQQLIQMFTTLRSIHPSTAREEMKIGSFASGICKDIRRCQRVSIKPIYNEIDFNDFLCHEEKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVR8</accession>
    <name>A0A7D5UVR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986515.1">
        <property type="nucleotide sequence ID" value="XM_066130492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVR8"/>
    <dbReference type="GeneID" id="90967752"/>
    <dbReference type="KEGG" id="mbrn:90967752"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028977993" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24969" checksum="CF895C6700558952" modified="2021-02-10" version="1">MYSLGLLAVAFAALVAGQYWDVAAVLWNEQGQSFMVGRVDQCVDIPPPIRGHVQWFELGPRSSGCIFFLENGCLVESEVATYDGNVDPVPDDVNQSRSIFCDELLSSLDILDYDESRRKLETSCKKLPLYSKCPTRDILENTNKQWSPVCYRQAGRTPAKESSRLSPSYEQNPENWNLFVNPETRMQYSKQGGFVEWTNKCKDGSSTTAVAVRSIMMEELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVX2</accession>
    <name>A0A7D5UVX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g029910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539706.2">
        <property type="nucleotide sequence ID" value="XM_014684220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVX2"/>
    <dbReference type="GeneID" id="26247463"/>
    <dbReference type="KEGG" id="mbrn:26247463"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028799118" description="Cell wall mannoprotein 1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="28771" checksum="BCB293DAF8873252" modified="2021-02-10" version="1">MRFSKWTAISSAISGMILSCNAAAPTPSNDTVVVAGMLQLTAESIHNATLDLKSKFTDLGGKDASDDAASQELGRLLQLATNTMSNGSAVIEAISKDSKSLGNLKYKRDLLGGLVQSAGDFFGGIAKAGASIVAGFSKAGGNALKGNLLGAGADILGGFVQAGTDFSGGIVAAGESIINGAVQDVSHTISSLVDVVAVPAISTLINLVANTVQLFISSFLNLGLDVLSRFNHDSFIQEKFAGLTEQLVNFLEGLKPFSTLPGFYPLVDDVTKVIVNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ6</accession>
    <name>A0A7D5UVZ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g043880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547723.1">
        <property type="nucleotide sequence ID" value="XM_014692237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ6"/>
    <dbReference type="GeneID" id="26240286"/>
    <dbReference type="KEGG" id="mbrn:26240286"/>
    <dbReference type="OrthoDB" id="4941437at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028950911" evidence="1">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="175" mass="17627" checksum="EB313C103A8B2D93" modified="2021-02-10" version="1">MKFFYMATVLASAALAVPQGVQRTREEHVRHQGDDIKKALRRQDTAQCNAMPQECMSSINNVFNGFMEAMASGNLIAASGVAAGFQAEVNSNGCMPKLSACASNMPNIQPSSPPSAAPSVVPSAVPSAVPSAVPSAVPSAVPSAVPSAVPSAVPSAAPSVVPSVAPGGVGRGVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWH7</accession>
    <name>A0A7D5UWH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542594.1">
        <property type="nucleotide sequence ID" value="XM_014687108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWH7"/>
    <dbReference type="GeneID" id="26244543"/>
    <dbReference type="KEGG" id="mbrn:26244543"/>
    <dbReference type="OrthoDB" id="3436397at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11377" checksum="994F04207A74D355" modified="2021-02-10" version="1">MASSNDSNAQQENFKTQLDKAAVDQRERDQDPKLNPIVEKIAEFIPAAGKVLAPKEKSPGEERDEIPGPPDRPHHDHKIEEFVRDQHRSKMPGGDLSAVAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWR4</accession>
    <name>A0A7D5UWR4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc cluster transcription factor acuM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AcuM</name>
        <name evidence="8" type="ORF">G6M90_00g033440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986407.1">
        <property type="nucleotide sequence ID" value="XM_066130130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWR4"/>
    <dbReference type="GeneID" id="26244073"/>
    <dbReference type="KEGG" id="mbrn:26244073"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="7">
        <location>
            <begin position="382"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="494" mass="54089" checksum="BE76CAF7CEABD9A7" modified="2021-02-10" version="1">MMDKETKTAERAKADKADKSDAKDRDKDQGTTTTNSKSPKKRRKERPCTRCIKRNIGHLCHDEPRDADAKKTKNGKTSAPVEESDTQSQAPSDVGRSSISSNMGPPTFDGMRQRSASGFSAGGVLGQGNAMPLVTPNAGSGLQGNGLNNSGTGNANQFSGISDAWLTAQNFNDMNSYNPNYMIAPHVTHEFNLLNDFLHNGLLDDNNLTGDETRQLTALGRLGQSDMLSGFGSGAGLSTGGSAPSTNLRGNLMPPPPSEGKGGRRSASSTADKTREYYLQAADPSGNDTAEDRMARVLRAKIDAGLLKPFNYINGYARLGKYLDGHIAPSSKQKILRTINQFRPKFREKAQGLTDMQLIIVEMWFEKQLMDYDRVFASMAVPACCWRRTGEIFRGNKEMAELINVPVDQLRDGKIALHEILTEDSMVRYWEEFGTIAFDPAHDTLLTACSLKNPSDASDHPVVKCCFSFTIRRDDHKLPALIVGNFLPHDPPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX61</accession>
    <name>A0A7D5UX61_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540928.2">
        <property type="nucleotide sequence ID" value="XM_014685442.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX61"/>
    <dbReference type="GeneID" id="26246234"/>
    <dbReference type="KEGG" id="mbrn:26246234"/>
    <dbReference type="OrthoDB" id="3231004at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48219:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48219">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028943303" evidence="1">
        <location>
            <begin position="24"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="647" mass="71296" checksum="78E4E9DA04BA0C06" modified="2021-02-10" version="1">MMEPRWCLVVLVLSALHIGPLLARSVPYGDLMTVGEGYNTFLGKGVKHGAVQFSSVKAAPPENIIPKRSASNTPTRRETNPFQGLSVDMFDVDLDSYFIAPDPKMFDEPMYKQNEDNQNGINHSVAHVKRNAAASCPAEIDASVEFISDYESYLKVLDVSASATISGYGQTASASSSYLDKSRFASNTLTYMAIINIKKQINTGEEFAFNTNLYSNSSFAKTFGDRWIRGFQMGAKLVARISLTAKEKSNQEELKATAVASLAFWGVSGQVNTAVTSSMQKLNTQAHVKVDIFYQGEIGKQLQGQSASTSGDQQPAQQVFANAKSWADLFLTEACKHNYKYQALLDEYPNIKGFPENQAVLDYSTAERVSYRVLSELVKISELAQVLRKSKVLNQADGDQILWDELAIVEACKTWVQKTAATPNNGTETAKELIKLFDTAFYEKWRPRLKDIKGDLTVQNTTEFVRVWDDRGSGAARGASFWLPRAQGELRPLGSMGVANYDDINSHFTAVLVAPTPGRTPSKPVVASPVGFNRIWRDLWSGANSDGSFWRPTAPEGYKCIGDVVQNSWSEPNKDAIWCLRADLVKPSAYESPSLWDDKGSGSAYGVHVYNVQPRSDKRLNVLRAFSDPDPDKNIASQLIAPSGANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX81</accession>
    <name>A0A7D5UX81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">G6M90_00g064820</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540062.1">
        <property type="nucleotide sequence ID" value="XM_014684576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX81"/>
    <dbReference type="GeneID" id="26247098"/>
    <dbReference type="KEGG" id="mbrn:26247098"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="121"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="421"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="525"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI69516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="622" mass="70635" checksum="10525F77A52A4D0E" modified="2021-02-10" version="1">MNDQSLLLMKARLEVVDFKTIAPFLQKFDRFLTLRTFIRGYTLGTADEQIWTVLRLNKVALGLIRRAIFPNLTRWFSHIESTYPDLRPTAVELVSATNTDATTNQTRGRYNIKLQATENGVVTRFPPEPSGYLHIGHAKAAFLNDYFTHDAFSGSLILRFDDTNPTRENQEFEDSILHDLGLLGIKTQRVTYTSDYFEELYDLCCQLISDGNAYAEDTDSKIQKDNRRDRLPSKRRDRPASESLAIFKEMREGTEFGKGHCIRARIAFDSSNGSMRDPIIYRFPSWDAENGPRPHHRTGWDWNIYPTYDFACPLVDSIEGVTHAPFLRALKLRPVYLWDFARINFIKTFLSKRKLAKVVESGRVDGWDDPRMPTIRGILRRGLTVAALREFMLKQGPSRNVVSMDWTTLWAMNKKMVEPTAPRHTAVASVGCVLATVAGGPDHPRQDSRPKHPKNHSLGTKDVTFANQIYIEQADAAAFQQGEEITLMSWGNAHVRQVTRSDDQTVTGLHLELHLDGDASKTDKKVHWLAAHGAEISRAELWEFDYLLTKDSLVKGDELEHYLNPVTSWLTDVLVGSEFSQLLEGDIIQIERKGHFRMDKPIGQGPSGKAVLFKIPTGNNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX94</accession>
    <name>A0A7D5UX94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein SYS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SYS1</name>
        <name evidence="11" type="ORF">G6M90_00g047330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544852.1">
        <property type="nucleotide sequence ID" value="XM_014689366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX94"/>
    <dbReference type="GeneID" id="26242193"/>
    <dbReference type="KEGG" id="mbrn:26242193"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="226" mass="24311" checksum="00688AD40FF65BB5" modified="2021-02-10" version="1">MARRRKPPRAGALSELQPLKIATQIATLQALYYTTAGILMLFTALVAGMSFSVDMILGWDAVRGDTTQGWLLSFIWLIDGGLCMAVAIVVLIARSKLVPDFALTIHLLHLVFTTLYARSLPRHSMWWMTMMASAAVAVALGMWGCRYRELQPVFFGGGRILGSNSAPAAASHGQVAAEEGQAGLDDDDDDGRGGAEDDGFSRGRGRGRGKDGAGEYEMVGMKQAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXM6</accession>
    <name>A0A7D5UXM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mtr_4</name>
        <name evidence="9" type="ORF">G6M90_00g066170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540156.1">
        <property type="nucleotide sequence ID" value="XM_014684670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXM6"/>
    <dbReference type="GeneID" id="26246965"/>
    <dbReference type="KEGG" id="mbrn:26246965"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="66"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="481" mass="51678" checksum="9FA958EC51A01C87" modified="2021-02-10" version="1">MSDPVVRDHAFSEHVKKEKDSSSSDHTPSDNVLSGPIEGEVTDFEERRTDLEKQKTAEGNAHFNRLGWKRLTVVLIVEAIALGALSLPAAFASLGMVAGVICCVGLGLIAIYTSDIVGQVKIAYPEVAHYADAGRLLAGRLGYEVVGAMFVLQLTFLVGSHCLTGTIAFLNITENGACSVVFGVVSAILLLLLAIPPSFAEVAILGYVDFVSILVAIGITIIATGVRAGQAEGGLSAVGWSAWPKEGLTFAEGFIAITNICFAYSFSMCQFSFMDEMHTPTDYPKSIWALGLIEIFIYTLTGALVYSFVGVDVKSPSLLSAGHTVSKIAFGVALPVIFISGSINTTVIGRYIHGRIYKDSITRFINTPKGWATWFAVISAITVAAFIIAEVIPFFNDLLSISSSLFISGFTFYLPAWMWFKLLKKGSWHSRENLLRSIANAACFVIGIVVLVCGTYASVDDIILSFQTGRTRGVFTCAPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYE7</accession>
    <name>A0A7D5UYE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541021.1">
        <property type="nucleotide sequence ID" value="XM_014685535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYE7"/>
    <dbReference type="GeneID" id="26246327"/>
    <dbReference type="KEGG" id="mbrn:26246327"/>
    <dbReference type="OrthoDB" id="4935592at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="422" mass="47232" checksum="9818DB8067F8A047" modified="2021-02-10" version="1">MTDSPPPGNISWKGVGDYGQEYAERIHKFIDKIDIKALGSYASSLRGNQPCNISTEFSVGNFHLVRKIQFHDGVEWIVRLLMPPLPVAGQLVETVSPKAQEKRFLSMQSELATMYQNTDIPIPKIFAHELNEQNAVGCPFFIMEYVHGNTAEEVSRSYPGNREGIPEPFREKFWRQIANIMTQLASVRLPQIGSIVQEAAGSFVAGPLIETGSGPYDSAAEFYADYPLALGNSLEEREGPVDGQGEVIQAFCSLAASFPPPAARAERGSAEDFGLANYDLNPNNILVDQEFNVLAVIDWDSVVSVPDAALYRFPYLMGVKCAVPGLVSTERLELKREALSQQFAEVVEAWGKEQLEKEFRGVNKRRMYLFTKSGFFSKEAVAFRSLLAVRQGQDWVNEERIQGLAWLSDRNEEQVARFYLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYK0</accession>
    <name>A0A7D5UYK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">[NU+] prion formation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NEW1</name>
        <name evidence="11" type="ORF">G6M90_00g061330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542735.1">
        <property type="nucleotide sequence ID" value="XM_014687249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYK0"/>
    <dbReference type="GeneID" id="26244684"/>
    <dbReference type="KEGG" id="mbrn:26244684"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0034">Amyloid</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0640">Prion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="474"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="719"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1106" mass="121593" checksum="69388C42A782CB3C" modified="2021-02-10" version="1">MPHPVSPPTMVSKDAAPPPSQEDVAGLINTISSAQTSAASVDASYGLCELLLNSVGYAGLNQYGVLAEIKKAAADKKNGLKRESSQNLLGAIFERFPPKQAVSEVVFLVQEEGLVPCALDALADKGAVVREAAQYGLDALFNNLSAEALVTGLLPVLTKYLDKKTGKWQGTVGAYKLLQKMADKAKLAIGASKEEAEEKDVLREAMGAKLAGLIPIVEAGMHDLKAEVEKQSVQTMNSLTTLLSNDDVTPRIPLLVETMQHPSAQATQKAIHALSQTTFVAIVTSPVLALLTPFLERSLNSPNTAQEVLRQTCVITENLTKLVHDPIEARTFLPKLSPGIKAVADRASLPEVREIAERALAIMEKAMANDKEVIARTTLDDVAKIVDEQIKKNGGLAAQQDIYKLVQPYISDMVAADVNYRFVNRIAARIAPYLQPLLQKPEAAQNIADAIQQHYVDEDHRRYGVPEKEDDGEVEIVNADFSLAYGGMLLLSHTNLRLLKGHRYGLCGRNGAGKSTLMRSIANGKLEGFPPQDVLRTCYVEHNQGEDADISILEFVAKDPEIGPQGTERISEVLTEFGFTPGAEGRQAQKVGSLSGGWKMKLALARAMLKKADVLLLDEPTNHLDVANIAWLENYLKSHPNITSLIVSHDSGFLDNVTTDIYHYEPGKKLACYKGNLAAFVKIRPEAKAYYTLSASNVQFKFPPPGILTGVKSMTRAIIRMTNVSYTYPNAPKPSLSDVSCQLTLSSRVAIIGPNGAGKSTLIKLLTGETIPSSGKVEKHPNLRIGYIKQHALEHVEMHLEKTPNQYLQWRYAHGDDREVHMKQTRALSDKDREQMDKWVDLKDGKSPRQIESLVGRQKYKKTLQYEVKWRGLLPKHNTMISRETLTELGFDKLVQEFDDHEASREGLGYRELQPSVISKHFEDLGLDPEIANHNEIGSLSGGQKVKVVIAGAMWNNPHLLVLDEPTNFLDRDSLGGLAVAIREFKGGVILISHNEEFVGALCSEQWHVNEGRVAQRANAAVSLDRFEDSRPGSAVASTAASSVVSSAVNSGVEDNSDMKFRARKKKKMTKKELKEREVRRRLRHIDWLNSPKGTPHPPDTDDEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYP4</accession>
    <name>A0A7D5UYP4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g062600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542621.1">
        <property type="nucleotide sequence ID" value="XM_014687135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYP4"/>
    <dbReference type="GeneID" id="26244570"/>
    <dbReference type="KEGG" id="mbrn:26244570"/>
    <dbReference type="OrthoDB" id="4942905at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="517" mass="58978" checksum="F5E8C34FD2B08732" modified="2021-02-10" version="1">MPQPFHGDGRGDCDAKKDEPMIIEASNSSTQYQSIPDHSDAVSKVDDCARELEAAVKQLLKRTEHARKAEQCQIMMQKKLQTLELENAAVLHRIHEMEEKYLKLEAITLEKDEQIRQNWQALQIAAQSYSELEQGRNLAIAVVEETQQTAKAYETWAKAEVERALQSNVAAHDHAKRAEEEMSSAVNRERESYHAREVAEGRAEDAEQARHEAEKRAEDAEQARHEAEKRVEDAEQARHEAEKRAEDAEQARQEKERRAEEADRARLEAEKAKALAEKHKEELERNQVWMITSTRQAEARAEKAEADLALAIESEKEVRRQLDTAAPVRHAIEPAVSLKRQKKGPFGPNKKPRLSKSAAHNGTGLQSPEITWHDERLQYLAHDLDRVVDNWGAEEVRYARFTFSTDSVQVDGVEKNCEITESSHLVRCVRHAEEIVVTIFDVMSLARKVYLTNLDLKAVEKLLHGNVAQTVSRRHAQKFKVGEETKRVTLFLWTNLADILNRVAEVYHVKDAVMVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYT7</accession>
    <name>A0A7D5UYT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g073970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987059.1">
        <property type="nucleotide sequence ID" value="XM_066130991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYT7"/>
    <dbReference type="GeneID" id="26241701"/>
    <dbReference type="KEGG" id="mbrn:26241701"/>
    <dbReference type="OrthoDB" id="4814848at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="42406" checksum="3C218559D8C51897" modified="2021-02-10" version="1">MNTNGDGLFDEPVASSTQFQHPKLWTDEYNNNLVKAWGSELCPRWARHDEFLCMEGDAIQTSRHFEDPVINEKPLIQDYSMHQPFSGISTGTSNNMKPFGGLILPDTSVNEDILTNSCHHYSLPGGFFDRNRSVGSGHEEHSSTSETIIDGIENASELTAQRMKRSVENEFNDISGPRRKKARKSSPTTAEMTPENKAIQDKSKESPTRVFQELFKSKHHADKSLKTIIELHRKPVSDCSFPTDDESFPKTDEEYRQRVRQVFDAICDWSYILEWRTVLPKGEENRISAEFSQDRPERRQGESMDDPPADFMPTEAELVKILPPVEDQQRRVLRQIPNDQTIEWISWGIVGAAIKSQQGDTQVPYWCVSEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYY8</accession>
    <name>A0A7D5UYY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exo-beta-D-glucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gls93</name>
        <name evidence="11" type="ORF">G6M90_00g066260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540147.1">
        <property type="nucleotide sequence ID" value="XM_014684661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYY8"/>
    <dbReference type="GeneID" id="26246956"/>
    <dbReference type="KEGG" id="mbrn:26246956"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043534">
        <property type="entry name" value="EBDG/EBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041351">
        <property type="entry name" value="Ig_GlcNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43536:SF1">
        <property type="entry name" value="MANNOSYLGLYCOPROTEIN ENDO-BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18368">
        <property type="entry name" value="Ig_GlcNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028925461" evidence="6">
        <location>
            <begin position="21"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="10">
        <location>
            <begin position="57"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="7">
        <location>
            <begin position="220"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="8">
        <location>
            <begin position="682"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Exo-beta-D-glucosaminidase Ig-fold" evidence="9">
        <location>
            <begin position="775"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="880" mass="97953" checksum="C0932C253AE0FC05" modified="2021-02-10" version="1">MALHSAAALLLASANALTSATNPLTSKAGQVGIIPAWDFQSSSSVSKDLASLSKPGVDTSSWNHVNDSRCTILGGMIESGAYKDDELWFSDNLYKINWGQFRVPWVYRNEFSLTPNQGQHYFLQTNGITSRADIFLNGEKIADKEEQAGSFGGHTYDITGHAGNENALAVNVYPSDFNLDLIYTFVDWSPRAPDNGSGIWREITVKQTGPVALGPMSVSIDIESPVESNPAKVTVRAKVQNLEDHELQVDASSVIAESSGCKVGSQKTSLMLGPKETKLVEISLHVKKPKIWWPKFWGGQPLYKARLALHVANELSDVAEETFGIRTVTSALNSHNDTMFTVNGYPFQVLGAGYSPDMFFRWDATRWANIMKYSHDMGLNTIRLEGMMEHPELYRMADEAGMMIIAGFVCCSKWEAWSYNQDINPNVPWTDNDYETANATMRHEAAMMQPHPSVLGFLIGSDFWPNDRATKIYVDALKDAYWQTPFIASASKRGYPALLGPSGMKMSGPYDWVPPNYWYDTESSEDRLGAAFGFGSELGAGVGTPEVSSLRKFLTQSEMEDLWKKPDANFFHMSTNTSTFYNRKIYNQGLFKRYGAPTSLEDYIFKAQLMDYEAIRAQHEGYSARWSQVRPATGTIYWMLNNAWPSLHWNQFDHYLHPAGSYFGTKVGSRLEHVAYDYVREEAWIINHSLDKKGTRNIATELIGLDGKSISKDSVTVDSVPNKSSKVAKISGLNNMTDVGLLRLVLSDEQGQALSRNVYWLTKSVDVLDWPNATWYHTPVTKFSDYSALSGMETAELSVTASRNDGAHSIVLENKSDVPAFFIRLNLVDKAGEDVNPAIWSDNYVTLWPREKLALTVSGDGREAKVLVNAGNVQALEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZP3</accession>
    <name>A0A7D5UZP3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g071730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="mbrn:26241919"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cir_N"/>
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    </dbReference>
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            <begin position="10"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
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        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
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            <end position="274"/>
        </location>
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            <end position="312"/>
        </location>
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            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="QLI70993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="148" mass="16839" checksum="5C63EE37E6604274" modified="2021-02-10" version="1">MPVGRSSFEETPHATHAAAADLDGRLEAGLPLSWFLVRPYSFSSPAQLLAGGYEKPSWVGEDGMRTLSRYWWIRASAILRTWPFKKAMHQRGDLDLIFEPLGLRFYNSEKRLLPRPLSGVVIYPQQAMYFSGLQELLVIRSDMRLPSV</sequence>
</entry>
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    <name>A0A7D5V0K7_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">fc-sdr_2</name>
        <name evidence="2" type="ORF">G6M90_00g091300</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="327" mass="36273" checksum="2A945623C3528BA2" modified="2021-02-10" version="1">MFKHLIDQLSQLYPPKPLFTEFELPDLKEKVYIVTGANTGVGKELSRILYSKNARIYMAARSQEKTLSAISEIKSSLPSSTGDLIFLPLDLADLTTIASSARQFLDREPKLHVLFNNAGVMNPPKGSATKQGYELQLGVNNLGTFLFTKLLSQRLVETAAAEEPGTVRVIWVASSAAEAPVVPRGGVDMKDIGRRLDKSEFTSYALSKAGNYLHAVEMAKRFRDKGVLSIALNPGNLDSELWRTQTAFMSRMLKTFVLHPPKFGAYTELFAGLSPAVTLDRSGHWVGPWGRFLTIRGDLKKAAEDGNSEAFWNWTEEQVQQYETPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V120</accession>
    <name>A0A7D5V120_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dicarboxylic amino acid permease</fullName>
        </submittedName>
    </protein>
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        <name evidence="10" type="primary">DIP5_2</name>
        <name evidence="10" type="ORF">G6M90_00g077350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689880.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="54"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="574" mass="62879" checksum="ADABF561E0868591" modified="2021-02-10" version="1">MNSEGIYARPGKGDGNGSDPEKASIRHNQYDNVEIRGLETSPETMLHKGLKARHITMIAIGGALGTGLIVGTGKALAQAGPGSLFISYTFVGLLVFMVMAGLGEMAAWLPLSSGFTGYATRYCHPSLGFALGWCYWMKYIIVTPNQLTAASLVISFWVPRERVNPGVFVAIFLVAIVCINYFGGIKFFGEFEFWLSSFKVIVVIGIILFALIIACGGGPNHDATGFRYWNDPGAFAQLYKSGPYGALGKFLGFWSVMVNATFAYLGTELVGVTAAEAQNPRRSIPKAIKLTFYRILFFYCLSVLLVGMIVPYNHEKLAFANKQTTGASASPFVVAATIAGVSGLPHIINACICVFVFSAANSDLYIASRTLYGLASDRSAPAIFRRTDSRGVPVYALAVGTAFACLAFMVVSDDSKKVFGYFVNLTTIFGLLSWISLLVTYIYFLKARRAQNISDSVMPYVAPQGLIGTYIALFFCILILLTKNFDVFIHHDGITFDYQNFITGYLGVPLYLILLFGHMMVTKSRGVGAHEADFYAGKDIVDQEESDFLDLQKEKIAASTGWSKFYNRYVSWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1C6</accession>
    <name>A0A7D5V1C6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g085400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541097.1">
        <property type="nucleotide sequence ID" value="XM_014685611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1C6"/>
    <dbReference type="GeneID" id="26246086"/>
    <dbReference type="KEGG" id="mbrn:26246086"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20566" checksum="089801E5CE647708" modified="2021-02-10" version="1">MLFSRHEIDSKSDRPVVLVYAKATLEMGNLGITGKWFSWQLKRNIPGTVAVQGVGYNCLTIPLSLVKGGSDSAAQKMVDAVHKAVKQSPEKKIVLCGYSQGASIIRKAVKQLGPETRARITGIILFGDPSRIGSKMPTDVGDKTLNLRLPLDWVHWPISIITVTHFWYPFLSYGEAVNFVRNQINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V209</accession>
    <name>A0A7D5V209_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g096940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546643.2">
        <property type="nucleotide sequence ID" value="XM_014691157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V209"/>
    <dbReference type="GeneID" id="26241066"/>
    <dbReference type="KEGG" id="mbrn:26241066"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="31303" checksum="8103E1E656DD805D" modified="2021-02-10" version="1">MLQFVRRAPITRHKFVQYNKYNKRNMHIQSIPMWVGSSSNYAYLVVDDKSKDAVIIDPANPPEVTPILKEAISSGRINLTAIVNTHHHWDHAGGNKKLLAELGTPHLQIIGGKNCEGVTKTPAHEETFKLGDILVKGVHTPCHTQDSICFFMEDDSGKAVFTGDTLFISGCGKFFEGNAAEMHEALNKRLGALPNDTVVYPGHEYTKSNVKFAISVLQSDPVKKLQAFADTNQVTTGKFTIGDEKQHNVFMRLNDPIVQKATGATDPVDVMGKLREMKNNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V267</accession>
    <name>A0A7D5V267_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g067610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540517.1">
        <property type="nucleotide sequence ID" value="XM_014685031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V267"/>
    <dbReference type="GeneID" id="26246624"/>
    <dbReference type="KEGG" id="mbrn:26246624"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="242" mass="27986" checksum="C3DA5823F2C81366" modified="2021-02-10" version="1">MDTASSKMTWKTFERRMAIYDDKVVKSEISEEELIHRADGSIVQPFWAKERLQNEAATLEFISKNTSIPVPKYRLYSKDGLLHLETQFIDGVELSEIDEASRPTAIAAVHDQLTRTIIPQLQALRRNSIGSVDPTLPVVPPQRVYMRDRRPWEKVTSDTDCFVLCHNDLGPQNILICPSSFQIVGIIDWEYAGYFPSYFEIPLWKTVGWKERWEVYHEAEARELAFFGLKREDLKDCIPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2D6</accession>
    <name>A0A7D5V2D6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g090950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541749.1">
        <property type="nucleotide sequence ID" value="XM_014686263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2D6"/>
    <dbReference type="GeneID" id="26245612"/>
    <dbReference type="KEGG" id="mbrn:26245612"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="43"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="216" mass="23177" checksum="2FA96B54260C44DD" modified="2021-02-10" version="1">MPPIIISSNIAPRTIRLGTKAAAANLAVRETSVTRAHYYPLHAAASLRAFQSTTPARQPKNQVYNPIRNPDTFNTYLSLSSSSRIPLLTLWTASWCPTCRTVLPLIQSLVESGTGESEGGVAFAPVEFDAPDIMSSSSYTENLAMTYMITSIPTLLSFDAGEAQTATKVTDGRKLADRQFLIEWIQHEARRHGGRGGGGDGGPGSSVYGGLFGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Q5</accession>
    <name>A0A7D5V2Q5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase MdmC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g093470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987553.1">
        <property type="nucleotide sequence ID" value="XM_066131446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Q5"/>
    <dbReference type="GeneID" id="26247779"/>
    <dbReference type="KEGG" id="mbrn:26247779"/>
    <dbReference type="OrthoDB" id="4863010at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43167:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22772" checksum="8C800E3C03CF52DE" modified="2021-02-10" version="1">MAGTATWAIEASPRVHELLKHLHTASASQEKSLSQVWFYLKTIIGFYIRKAAWPKAADDHMRHKFVSLEQDKCQFMYLLARSLGAKNIIKAGTSFGVSTIYLALAVGQNARDARVMGMRATGKVVATEKEATKAAKTMDYWMQAGDEVEPWIEMREGDLRETLQVTEGMPEHVDMLLLDRNLDSDGAAGHPERSAATVQGSYDPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V324</accession>
    <name>A0A7D5V324_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Indole diterpene prenyltransferase ltmF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltmF_1</name>
        <name evidence="2" type="ORF">G6M90_00g105060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541495.2">
        <property type="nucleotide sequence ID" value="XM_014686009.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V324"/>
    <dbReference type="GeneID" id="26245745"/>
    <dbReference type="KEGG" id="mbrn:26245745"/>
    <dbReference type="OrthoDB" id="5392033at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF5">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="421" mass="47094" checksum="A9F515A57FFA9381" modified="2021-02-10" version="1">MANQASMTNLDLRYWMRHSVPPLLALLRAAGSYSEADQGKHIQFLCDHVLPNFGPRPTDDSSSKSWFTQSGFPMDLSLNLNAGQPKVRYAWEFIGPNGPEDGDMYAIGALRKCLASLSTELGFSTQWADALLDALAPTSEEATTTQQNIQQWQASLLPPGVEPKAGARLPFAAVAFGLDGPRTDTKLYISPQIKEMGSVKSMNETIWNVARHLEPPISQNAITAVSEFLLERPGPPCMDLLCVDLVKEQDLHRARFKIYIHTTSNSFNTVQQCITLGGRRQDEVTLKSLEVLRSIWHLLLQEKEEVTNDYEKPVNDPAMLVMKLFFCIEITPGQDLPDVKLQVPIFNYLKSDSETIENLEKIFQKCGQEWAVNGKYKEAFELAFGDPSTDREVPIHGHTSFSCTASGVYQTLYFSVPRCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V372</accession>
    <name>A0A7D5V372_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g090140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541672.1">
        <property type="nucleotide sequence ID" value="XM_014686186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V372"/>
    <dbReference type="GeneID" id="26245535"/>
    <dbReference type="KEGG" id="mbrn:26245535"/>
    <dbReference type="OrthoDB" id="4941143at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="238" mass="25237" checksum="8AD1F7A746E2522F" modified="2021-02-10" version="1">MSSTWQDLAPPQESPDHPSQSIPNAAYPEAPYQPGSGFHGDASTPASTSLATSVTGNNTTSYSASSTASPNQSAAHTGPSSWHQTAVLSTSMPDSPPPPYVRDQHSSPYITAQTRPASHWTGTQSNRRVEQPDSVPLQRLPPAASSQCYRERSAASIAQHDQLPSAYTTGSGSITASTRTVKLGSVAEARRRRRRRVIICLVLLAAVIVFVLALTIGIALGVLKNTARDDRNNGPVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3C4</accession>
    <name>A0A7D5V3C4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon-induced GTP-binding protein Mx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mx_1</name>
        <name evidence="5" type="ORF">G6M90_00g087410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542376.1">
        <property type="nucleotide sequence ID" value="XM_014686890.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244890"/>
    <dbReference type="KEGG" id="mbrn:26244890"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="29"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="602"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="698" mass="79005" checksum="5070198F525261D2" modified="2021-02-10" version="1">MAVVDLESREHRDLLDLIDKLRSKGINQYVALPEIVVTGDQSAGKSSVLEAISGMSFPTKDNLCTRFATELILRRSSSVGVKISILPAACRPMPEQEKLKRFRPVVEQGSLELSHVVEQAKLVMGITPTSKAFRNDILRVEISGPSQPHLTMVDLPGLFQAGNSVQSDEDSETVTNIALRYMEQPRSIILAVVSAKSDIALQQVTRLARRLDPEGRRTVGLITKPDTLDEGSESEAAYIRLAQNEDVRFKLGWHVLKNRDYKMTLNKATSQERDDAEREFFSKGPWAALDPSIVGVKALKPRLSHLLKDEILLQLPNLVKDVETGIRKCKSRLMRLGSARENIFEQRQYLVHISQAFSDLMKAAVDGFYNDPFFGSSKSEEGYQKRLRAVVQGLLIDFKDNMNEFGCTRHIVDSDDESDDEGMTLSGNKVLRSAYVEEVGELMNRNRGCELPGTFNPLIVGDLFFEQCKPWEDITEILFKKVLESVKRVAHEIIAHVTVESTAAKLGRFIRPAIQVLSQELEASFQSLLKPYQKIHPITYNEALTENVQKAQAERRRRKVEARLTKAYPIEMYGAQRLTVTRQAILEIFTAEEDVNMKLYGSSLAVDYLQAYYNVSLKKFIDDISTLGVECCLIQKLRSLFEPRDIYKMSDTEIQHLAEEDPATKLERSRLREKLNILDGCLYELRGWDKFNPNAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Q6</accession>
    <name>A0A7D5V3Q6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sulfate transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g100080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546341.1">
        <property type="nucleotide sequence ID" value="XM_014690855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Q6"/>
    <dbReference type="GeneID" id="26240764"/>
    <dbReference type="KEGG" id="mbrn:26240764"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="758"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="974"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120525" checksum="668986F04DF59E73" modified="2021-02-10" version="1">MSTSILSFSPWRSRSSSFSSQIACQQSSHDDVAEAATSHDDSAQRLSSSAGSPKAYREPIRSYLHASVRGQLPPVDSEQNARTVREDTAELASYLLSDGTTARRPSFLQRNRASAQDLFSQAQDGRKRTEDDAAASGTIPEVSEPASPEGRDMDTAADTAADIAAEESGPSMLSNLLKRSPPHSVTADAPISTEPRAVESRQRRKASEDEHDQPRQPEQTPAATEQTPLLGHVSDESDDIGDLEGQKDTQLRKWYAGFVEKGQKLEGHVSHVVRVAVNPHRWNRKALWHNMVVEPVSCLPAVTVGLLLNILDALSYGMILFPLGKQLFSHLGPAGISIYYVSTIVAQVTFSSGSIFRGAIGSELIEVVPFFHNMAQKIMDNVGEDKPDAVIATTIVAYAASSIMTGLVFYLMGKFKFGYMVGFIPRHILIGCIGGVGWFLIATGFEVSARLDGLEYNLDTLNKLTRSDTLLLWIFPLVLATLLFYGQSKIRSKYFLPLFILAIPLVFYIFVFSIDALEVGALRDKGWIFQGPPQGEPWWYFYTLYQFNLVQWDAILEVVPAMMALTFFGILHVPINVPALALNTGEDNADLDKELKLHGYSNILSGCMGSIQNYLVYANTIFFVRSGGDNRLAGYILAAATFGVMMIGPSLIGFIPVMMVGTLIFDLGFELLLEAIWLPRKKLKVAEYLTVIVIVLVMGIHDFVVGIGVGILLAFVSLIIQTSRVSAVRGSYDGGVVSSTVRRNPSQHHYLNQVGQQIYIMKLTGYLFFGTIVSVEENIRALLDDHAFSKKPIKFLILDLWHVTGLDYSAGEAFNTISRLLDKKGVLFVLSGVDAESQLGRNLRAVGLDNDKIEVNMLPNLNSALEGCENELLKTLYARQEELNSAKRIATPSLDVPTAPNSSSLSSFDPPFNSPRQTHLVEAAREALTSVDIPHPSKWQGFNEPLRLMLQIFQGLSGKNEDFWFQATPYFKRKEYPAGTVLFRRGEEANGFYLVERGILRAEYDLPQGWLCESIVAGTTCGELPFFSETERTATAVVERDCVVWQMDCEAWEKLQKDQPSVAREFLRISLKLTSERMSSITSYILTTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3V3</accession>
    <name>A0A7D5V3V3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545973.1">
        <property type="nucleotide sequence ID" value="XM_014690487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3V3"/>
    <dbReference type="GeneID" id="26240396"/>
    <dbReference type="KEGG" id="mbrn:26240396"/>
    <dbReference type="OrthoDB" id="3758675at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="144" mass="16191" checksum="45B5B488A06B9F17" modified="2021-02-10" version="1">MPVKDTRVFGGNGGHPYELYPQNSDANVKLLEVWSGWGTKDCKDKWVLKGIGLTWTDGQHKELYNRIEDDDMYQTFHFPRDGSASWDLRSGARVDELKFKTKRGVPWVTGGSGGKEEHLADGALVGFHGKASDDIDSISMRYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Y5</accession>
    <name>A0A7D5V4Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sua5</name>
        <name evidence="15" type="ORF">G6M90_00g101560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546189.1">
        <property type="nucleotide sequence ID" value="XM_014690703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Y5"/>
    <dbReference type="GeneID" id="26240612"/>
    <dbReference type="KEGG" id="mbrn:26240612"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="14">
        <location>
            <begin position="40"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="437" mass="46751" checksum="B733AF430BE6D9D1" modified="2021-02-10" version="1">MNTRVVAVPHKGTLGSFDDSKDPLGRLEHWHIHRDARDAVAALEPAAEYLKTKDTPVAFPTETVYGLGADATRSASVKGIYSAKGRPSDNPLIVHVCDLDMLRTLLGSRGQDAIPARYQSLIESFWPGPLTILLPNPDPSPLAPEVTAGLDSFGVRMPSSPLALTLIKLAGVPLAAPSANASTKPSPTTAQHVKDDLDGRIEMILDGGSCQVGVESTVVDGLCDPPVVLRPGGVGIDELRSCPGWEHVVKAYKDQSEEGKAAPRAPGMKYKHYSPRARVVLYESSYENGRAGIVEADAEAVAATAIGGTHAVNGTARKKVGVIRTKRWKPAAGLRCSKLRLDARRIGHSQQGGQHDEMPYDVCAGELQNEQGETVGQVFDIGLGQETRRIAQGLFSALRELDRRGADVIFVDGIDDELDIAAAVMNRLRKAASETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V718</accession>
    <name>A0A7D5V718_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trans-enoyl reductase ACTTS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ACTTS2</name>
        <name evidence="4" type="ORF">G6M90_00g106160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539606.1">
        <property type="nucleotide sequence ID" value="XM_014684120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V718"/>
    <dbReference type="GeneID" id="26247603"/>
    <dbReference type="KEGG" id="mbrn:26247603"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="362" mass="39265" checksum="7C6ADAD748EF1BDE" modified="2021-02-10" version="1">MAISETNYGLIRKATGVAAFERIPVPTLPDDYLLIRVVTVAVNPTDWTTLDAPGDDGTLVGCDWAGTVEEIGPKVKKAFKKGDRVAGFAHGGNDARPQTGAFAKFIINKGDTVIRVPDNVPWEAAASIPCAVGTMGLGLFKFLSIPFPGLEAIQTAKASQDDNKTVLIYGGSTATGTIAIQFAKMAGYTVITTASPKHFDLAKSRGADLVFDYHSPTVGEDIRKATDDKLIKVLDTVSKESSAKISAEALSSKGGTYVNLLGEHDAPRSDVESIFFLVYGITGEKYIFEGKHWEAQPTYYEFATTFFPVVEKLWGEGKWTEHPREVRSGGLVGVLDGMKDMKEGRISGYKLLYRVDETPWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM09</accession>
    <name>A0A7D5YM09_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">BNA6</name>
        <name evidence="15" type="ORF">G6M90_00g002390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542841.1">
        <property type="nucleotide sequence ID" value="XM_014687355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM09"/>
    <dbReference type="GeneID" id="26244214"/>
    <dbReference type="KEGG" id="mbrn:26244214"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="119"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="294" mass="31017" checksum="9B9A24136C1639F8" modified="2021-02-10" version="1">MATDNKAHLLPPSYKTQITAWLAEDTPTFDYAGFVVGEVPRRATLLAKSPGILAGVPFFTEVFAQTGCSVEWHHAEGAPLDPSSSPGGKVQVATVAGPARGILLGERVALNTLARCSGVATQSRRVVSLVRGAGYAGVLAGTRKTTPGFRLVEKYGMLVGGADAHRMDLSAMVMLKDNHVWSRGSITDAVRAAKAVAGFSVKVEVEVQSEEEADEAIAAGADVVMLDNFTGDGVRAAARSLKERWAGRSFLLEVSGGLTGDNVEAYVCNDVDIISTSSIHQGVPHVDFSLKIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YM73</accession>
    <name>A0A7D5YM73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Curved DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdb4</name>
        <name evidence="4" type="ORF">G6M90_00g013520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549169.1">
        <property type="nucleotide sequence ID" value="XM_014693683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YM73"/>
    <dbReference type="GeneID" id="26238613"/>
    <dbReference type="KEGG" id="mbrn:26238613"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="417" mass="45121" checksum="ACD948D181F0D556" modified="2021-02-10" version="1">MSDEKDAVDYSLNNPDTLTKYKTAGQISEKVLAEVSKLCVPGAKIVDICQKGDKLLEEEVGKVYRGKKITKGFSHPTTVSPASYVTPYTPLTSDESEATLEIQPNEPIKVQLGAQIDGFGAIVCDTVLAGENKDEVLTGRPADLLLATHYANELLLRLMVPPGLLAQGTDEEKAKAASQKPPTQAKMTSLLEKVCEAYGCNLVESTTSWLFDRNEIESTKKIVLAPQDGGKGDGVPAISEVWGVEMGVSLGSGKCKALDGRATLHRRTTQTYGLKRPTSRKILSEVQKKFGTFPFSLRQLEDERDAKSGVVECVRGNVFRQYELVGDKDNAPVARLLTTIAITKNGITKLGGPPALDLSKVKSDKKITDEEILKILEQPLARNTGKKSKSKKKKKPAKKAAAAAAEDSDDDSDDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMY1</accession>
    <name>A0A7D5YMY1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
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    <sequence length="681" mass="75920" checksum="0A387C886F713D65" modified="2021-02-10" version="1">MIGRTEKTASPTVLFISENDHYRKEARKVIKESGILKQHPGFKTAHISRDPGWGGPLEQLGLCQETKGSIENPTGGPETPVFYEYSKRLHPTMTIYVRHGSSTRVATANGIRLHGHLFYLAPSHVFFDRLDNSQTSQVDDDFEIDSESESEYDDAAEASITSMGSQSTEALSDQDDLSDDELHSKTTLDSPQSSNIMASSPGPRRLSKSSFAKEQIAHPPREITTPPWASLRQLGLLFDWCVDQDWALVKVIEGTDPNISAFLSSFVFNPLDLSAARIAVLPKDGARVITHTASGGQMTGSILGMPSYARLPRGKSFQEVFAVHLDGPLADGDCGSAIFGADTGELFGHIVAGCRSTGFAYVMAARHVFPKLAKSALRIKDMERRHERCLISSDDDAAIEWDDKDQEIFVVPPRSQHNTMVTPLTFGHKMAVPGTLVPRRVDRQDVQQPADHAERDGGSFELTQGLHLASQARAQSTWQERFRSSASDHSSVHPMYTAHPAKYGPKPVGSQISKVYEHRRILLPCEFRKFSGCQKQFDLHDKDSWIDHIIDEHLHGRCPRVSICWFCDESVFRSGSNQKDEKLESFRQRMYHTATHFKEGMTAADIRPDFYFLDHLRENNLIDESTFRSAKKLGELPGGYSTRPPGGNETQSEVVVESSRSWCRRQSRDCQPGSSTKPNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN57</accession>
    <name>A0A7D5YN57_9HYPO</name>
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            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
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        <name evidence="22" type="primary">PAN1</name>
        <name evidence="22" type="ORF">G6M90_00g013430</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
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        </source>
    </evidence>
    <sequence length="1477" mass="159703" checksum="2C5438A52E6C18A1" modified="2021-02-10" version="1">MYSSSNAFLGGNSQRPGGQQYGAGSFNTGMGPGGPQQQQQQPSPFAPQPTGFAQQPLQQQYTGFPMQAQPTGMPQSSQQPLQQQYTGFPGQTQPQQSYQTGAVPPMPSIPSQYQQQFQQQKQQQQQQLQQPQPQPQPQSTLPVPLPTGFASTSPVQSSAPAPPPMKPQATGFTEMAASFHTGGTAKPQGRRAEKTNKIPNIRLSFITAQDQSKFETLFKSAVGDSSTTMSGDKARDLLLRSRLDGDTLSHIWTLADTTRAGQLYFPEFALAMYLCNLKLTGKSLPASLPDNIKNEVSSMVDIIGFSVVDDVPASSSATNAPSFQTDTTSPPVIQQPQPQPSNSQLLQSQMTGFPGQQTGFGVQPQGLQTQQTGYPGMQNPQPTGYQGPRPPMPPMPPMPTGFGQGPNDGSMAVPLNAQPTGRPGQWGLVNAPASGLPNIDALQARMMPQQGREAGGYTTQGLQGNAVIPWAITKEEKTRYDALFRAWDGFGKGYIGGAQAIEIFGQSGLEKPDLERIWTLSDNGNKGRLDLDEFAVAMHLIYRKLNGYPLPNNLPPELVPPSTRNFSQTIGTLKSMLNQESDFRKNSGAALLPQKTGVSYMKNRSFRGTAVGAQGGRKDATVFRNDDEDFGYRSSARRRLGNSSPRSESPSSVASSDDLSLDQLRKKIKEKQVLLDAMDFADERNNEEDDILDRRDRRESEELYRRIRRIQGDIDAHPDAALATGDSDAERRALKRQLQNLTDKVPELASQVRRTEKDIMEARLELFRLKDAKAHPNSGPQIVGTGPGGTVTESDRLKARAKAMMQQRTAALTGKKIDIGTEDADAPKRLEEETIKVKTEKESNESMVRDVEDSVRDFSRGIEDSLKEGGKDDSSEHEKRRWEDALGVEDEVRDFIFDLQRESRAARLRSQDKGSARAPPAVEQSRPERVASPRVESPISTSRTATPPTAGGSYNSYKTPEERAAYIKQQAEQRMAERLAALGIKAPVKPGETAAQRAERERAERSAKLKQAEEEDARREAERQARLADEQGVPPPVPASETPKATARAPPPPPTRKAARVDTSEEDVATLVEEERAAKAAEEARINKEREEQQRETRAMEESVKEEEDEFAKEQEEAAARLKALEEQVRQGKLRKEEEKKRKKAALAEAKEKEAKMAARRVEIEAAKQRELELQRQLEALDDDDSSSDDDDGPEQITPQESTPSGSQIVHQETEKWHSPPPAVLPTAPPVPTVVTSPPADIESKNPYDSVIPQPAESSSISQAHDYTPAPPLPRPGASTNPFNRMGQPPAAAPGPVSRKRADSDDWGSDREADEDSDDDRPGGGNAAQLASILFGTMGPPRPLSATGRDSTPASPAPANDTPVASPPPPPPPAPPVPVSNGPTSPPPPPPMPSSDAPSAPPPPPPPLPPTGAAPPPPPMPGAGAPPPPPPPGDAPAAPPSGGRPAGFLSEIQLGKSLKKTKTNDKSASAVAGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YND1</accession>
    <name>A0A7D5YND1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">54S ribosomal protein L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRPL27</name>
        <name evidence="7" type="ORF">G6M90_00g038430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547201.1">
        <property type="nucleotide sequence ID" value="XM_014691715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YND1"/>
    <dbReference type="GeneID" id="26239764"/>
    <dbReference type="KEGG" id="mbrn:26239764"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="104" mass="12094" checksum="51BC010E028A8E01" modified="2021-02-10" version="1">MRPTQALSVGRYRHLKLTTKDVGKGFYKGNRTGSMGRHTKHGGYVIEWNKVRTYAVPPNLKDFKLTPFVSRQVREVPGDYKGLEKGPQDPYFYVEQWKRYNGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNK1</accession>
    <name>A0A7D5YNK1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g047090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544831.1">
        <property type="nucleotide sequence ID" value="XM_014689345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNK1"/>
    <dbReference type="GeneID" id="26242172"/>
    <dbReference type="KEGG" id="mbrn:26242172"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="307"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="45925" checksum="DC21DDE62E906BEC" modified="2021-02-10" version="1">MKIILHSHFPAGHTYPMQAVAQALVAHGHTVLWLSNPDNEARVLASGANFIPTKAIAALDSPLIKAHKTGLFDQPRSGLDRRLLAQVADYRAALAALDADVLLVDVLPQGARALCQLGEIPTYATLGVIPLYTSALDAPLAASGAAPPASWARWLTNAASQLAGRFVQAPLFLRPATNRQRRALGLPGLRLGEPLEESAYSPHLHVQASSLELEFNQLPNTAAHRKHTVFVGPLVTQTGTELSRLPSWWSGLSSQNKTIVGITQGTLAMDPASLVIPSIEALQHDDGLALVVVSPYEAEIRSRTRRTENVYHAAWLPYDLLLPRLALLITNGGYGSITQALSHGVPLLCAGQSEDKRDTAARVAYSGLGIDLKTDSPDVESVRQAAYAILGDEGYRSRAREMGDELSRLGGADAAVEALEELVRNNTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNS6</accession>
    <name>A0A7D5YNS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g010510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549467.1">
        <property type="nucleotide sequence ID" value="XM_014693981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNS6"/>
    <dbReference type="GeneID" id="26238911"/>
    <dbReference type="KEGG" id="mbrn:26238911"/>
    <dbReference type="OrthoDB" id="4941567at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028988372" evidence="2">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="43408" checksum="AA48E1D03F203D73" modified="2021-02-10" version="1">MRCGTGIVAALPLFLSAAVLAGSPDEGCSSTITKTLAETTSIIMAPTSTCNQIGTAKPTESLGSQGNHGHGNNQDKVPASSGSGGHDGGNGNGNQNGNGSGNGQNSSGNTPISGPDSNLGSSNELDNGSGSGSNGEAGSNLGSNSGPGNGVSSSTGSLPDEASSPTHGPGNSNRPESGAENESGCDLGPSPGNSDGVSSGTGSEPDDGSAPGNDSGSGDMENESGSSLGSNSNSNSAPGSGIGSGSGPKPSYESATGNGHDSVSGSDSGTGNGIYNSPGYESAKDFQPGSGSGSDSDSDSDNRGGNSSSGSESKNGASIQPDNPGSHDSGTVNYKDNKSGKGNGSGNPTGTDAANGSGNGSGDDGFGSGSGENGSGSGKGNNAGHSHTDGSSSIESGHGSGGPSGGVSGSDSGSGSSAHGSGSTYGNASTATPPVVTAGASPSRSSARFASSLVGLAGFLCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR94</accession>
    <name>A0A7D5YR94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">crn1</name>
        <name evidence="12" type="ORF">G6M90_00g014630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985593.1">
        <property type="nucleotide sequence ID" value="XM_066129756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR94"/>
    <dbReference type="GeneID" id="26238503"/>
    <dbReference type="KEGG" id="mbrn:26238503"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="583"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI63544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="609" mass="66814" checksum="94C4864DF2C74BEB" modified="2021-02-10" version="1">MAGRFVRASKYRHVFGKPTRKEFCYDNLHISRNAWDTNLVKVNPEYLSVNWDSSGGGAFAVIPLNERGKLPDQIPLFRGHTATVLDTDWNPFNDHIIASGSEDGKVFVWEVPRDFTLYTDAEDITDVSPVGKLAGHSRKVGQVLFNPAAENILASASGDFTIKIWDVGTGQASLALKHSDIVQSLSWNASGTMLVTTSRDKKIRVWDVRQEKPVHEAAGHSGAKNSRAVWMGEHNRFATTGFSRMSERQIGLWEPGRTEPIGGFTMLDSISGVCMPFWDEGSNCLYLAGKGDGNIRYYEYENDKFEFLSEYKSPDPQRGIAFLPRRGINVHENEIMRAYKTVNDSYIEPISFTVPRRAETFQADIFPPAVGTKPAVGAQGWLGGKTGIPAKIDLESIYDGSAPKEVPSDYKPPAQPAPAPAPAPAPAPVKKEEPKQEVQKPAPVTRGPPPTMNDQKTSISNLANKFQDTEGDDQDDQDETSSFEEISRPTQRVAGRNDPKPLPVPVKTQPAPTPEPAKVASPAKTPTPTTASTAAAPRSSTPSVGVEASLDQIKQLLENQAKIITVQNDKITQLVGEVESLKKKVNTSGSQDQSERIRQLELELEEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRT7</accession>
    <name>A0A7D5YRT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SmrP</name>
        <name evidence="3" type="ORF">G6M90_00g036370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547029.1">
        <property type="nucleotide sequence ID" value="XM_014691543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRT7"/>
    <dbReference type="GeneID" id="26239592"/>
    <dbReference type="KEGG" id="mbrn:26239592"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="451"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="535" mass="58521" checksum="9F533E0A0978ABAA" modified="2021-02-10" version="1">MATENEPELLQNLVDSFHTLLDEALIVAIASDYNLKSPSAYKQAQATLQDLAKSVPSEEASGFNPSGIPQGPEGEAQLVQDEPTATSTTSASRRTSQAHITDKSSTDNSSCVPDSPSLMPRLTTFNQDSEEDKLLLLQSMFADLKQFDIQYALKKANGEFQTALDDLLNVQYLQSTGQQIKGIDGFFELENGRSKGRKKKKGKKKVASDADQSSDGTSSPSIASETQSQDEIEYVAERFGIRSDQVSPIYYKLQCSKGATVVELLNQYISHGIETQDESGKESAERLAQNYRHVPEKYMPTIVHVAGSIPQFADDIAALLNKYFSRQPKAKKMDLSYRLTPLPQEDIEGGDVIVSPRPGAKPAVGLVAKPSPISDMNYEEAMSRANTFHQARRDAAASAAQMHRRGASSPLFRQAASYYSDRAREQGRYAQSATSTAADILVDQRSTASSIDLHGVLVQDGVRISRQRVQEWWGGLGEMRAKKLREDGGFTVITGLGRHSASGVSQMRQAVAAALLQDGWKLSVETGRFVVTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YST4</accession>
    <name>A0A7D5YST4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-specific GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sbp1</name>
        <name evidence="3" type="ORF">G6M90_00g041710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547514.1">
        <property type="nucleotide sequence ID" value="XM_014692028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YST4"/>
    <dbReference type="GeneID" id="26240077"/>
    <dbReference type="KEGG" id="mbrn:26240077"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="94"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="244" mass="26837" checksum="54F9E9989E13C8A8" modified="2021-02-10" version="1">MSGAENTEPKVEETKPIETTEQATGSASDPAPAAADEKPVTSSAVFSMFGGGAKKEKKDEDEDRGDTSGSAKAQREAAKAEAGEEDAPESEDVHFEPVIKLTEKVETKTNEESEEQLFKMRAKLFKFSKESSEWKERGTGDVRLLKHKENGKTRLVMRRDKTLKVCANHYIVPEMKLSPNVGSDRSWVWNAAADVSEGEPEACTLAIRFANSENANLFKDAFLKAQKENEVIFGKEEGSTAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT30</accession>
    <name>A0A7D5YT30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g037540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547115.1">
        <property type="nucleotide sequence ID" value="XM_014691629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT30"/>
    <dbReference type="GeneID" id="26239678"/>
    <dbReference type="KEGG" id="mbrn:26239678"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="570" mass="59236" checksum="8C846E7DA1DAF0F5" modified="2021-02-10" version="1">MSRRAPNPSADRAAQNQATIKNLLRLEPNKVCADCKKNKHPRWASWNLGVFVCIRCSGIHRGMGTHISRVKSVDLDSWTDEQMQSILSWGNARANKYWEAKLAAGHAPSEAKIENFIRTKYELKRWVMDGPMPDPATLDVDGDDDVPLSLVKEKQVIEKKESIRKASIGKSHAPQQIRAPEADLIGGDDGPPSRSSTAGPPVAKIAPKAEPAAPKTTNTRDSLLGLDFLGGSTAPPRPASTPGATSQGAKSRPDLKQSILSLYASAPKPQPQQQPQQQAFGGMGHQQQGSMGGFHDAFGGLNLSTTASAKPAAADPFASLGSTSSSNRAKPQHTSNASQFGGLSGGGFFDPKPVQPSTTSHQQKPSNSGFEGFSPFSSPPTQTATAPAPKPLQSSSSAMDDLFDFSAPTTQRSPPLPQTSSPSATTNSAFMISSPQTKSAAPAPATTSSAFGSAAISAADVWGTNDWTTPAPAAPTASVAQAPPSPQQLKAPAPAPAPAADFGWGNTSSSFASTPIVPGASGGFNPAPKVTADEEFGGWASSTAPSNTGKPAVPKSGFGGDDDLFSNVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU36</accession>
    <name>A0A7D5YU36_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cwc22</name>
        <name evidence="11" type="ORF">G6M90_00g015550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986049.1">
        <property type="nucleotide sequence ID" value="XM_066129773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU36"/>
    <dbReference type="GeneID" id="26238417"/>
    <dbReference type="KEGG" id="mbrn:26238417"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="377"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="578"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="723" mass="82153" checksum="96890BBFAC5050DB" modified="2021-02-10" version="1">MASADVSIPRRERERERGPQREADSYRPPPRERTPPPVRTEEEKQAAAKAEYEKLLNMRSGGTYIPPARLRALQAQITDKTSKEYQRMAWEALKKSINGLINKVNTANIKHIVPELFAENLVRGRGLFCRSIMKAQAASLPFTPIYAAMAAIVNTKLPQVGELLIKRLIMQFRKGFKRNDKSVCLSSTTFLAHLINQQVQHEMLAGQILLLLLHKPTDDSVEIAVGLCREVGQYLEDMQPSISVAVFDQFRNILHEADIDKRTQYMIEVLFQVRKDKFKDHPAVKEELDLVEEEDQITHRAELDGEIDVQDGLNIFKFDPNWEENEEAYKKLKAEILGEGSDYEDDDEGDDESSEDEEEEETKAMEIKDQSNADLVNLRRTIYLTIMSSADPEEAVHKLMKINLPAGQEPELPSMIVECCSQEKTYTKFFGLIGERFAKINRLWCDLFEQSFAKYYDTIHRYENNKLRNIAQLFGHMLGVDALGWHCLSVIHLNEDETTSSSRIFIKILFQSIVEEIGLPKLRTRMTDETLRPNLEGIFPKDNPRNIRFSINYFTSIGLGALTEEMREYLQNMPKPALPAPAAAADESDSDSVSSYSSYTGSSYSSRSRSRTPARIRGQPVPFTAAFTFSVIRFKVTVSQARTQRLLLGLASTTIRLRKQIALAGAKTKRKATQRLVQLVQPLSVARSPPPFSVRQSASRTGPFAEGRVVPSQQLFRKQRATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV53</accession>
    <name>A0A7D5YV53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AMSH-like protease sst2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sst2</name>
        <name evidence="11" type="ORF">G6M90_00g047680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544885.2">
        <property type="nucleotide sequence ID" value="XM_014689399.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV53"/>
    <dbReference type="GeneID" id="26242226"/>
    <dbReference type="KEGG" id="mbrn:26242226"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="362"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="60637" checksum="BBD50B8BE30C74FF" modified="2021-02-10" version="1">MDAGSGMRPTRPQSVKELVAQAENFTFNANIPFKHWTRAAETLYQEASFALSDGDYGRAYMMLYRHSVLVLRCLQTHPQFKDPESRKAFRPLSKRIDRVIADLEEIKPIINDEYAEWERVRPAGSKLEEQGPLKSPSSYGEFAARDPSLSGNATVLDASENQELAVELAQKELARRDTVRQANRRTRVYGDTILTSRLGDGQKLDFSLQSQMEAVRRATESSQQDLYESQTHKPTTTPHREAVPQSYVYPSISKSRPLQLDEAPQTPPRPPSLSPPSRPPKEYIHAPPRDPSYISRRELPVVPNKVPVADSLSASYPSYEVARKNQPPLPPKTLDGPSLPKKERLAFKPGAYLENGDPIRSVFLPSKLRAAFLDVAAPNTNKGLEMCGILCGTPVNNALFVRSLLIPDQKCTSDTCETENESAIFDYCAGEDLMVLGWIHTHPTQTCFMSSRDLHTHAGYQVMMPESIAIVCAPRFTPSYGIFRLTHPPGLDHILDCRQSETFHQHSVDNLYRETEYPNGHVYESEKMPFEVKDLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVX1</accession>
    <name>A0A7D5YVX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ATG18</name>
        <name evidence="15" type="ORF">G6M90_00g007940</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549714.2">
        <property type="nucleotide sequence ID" value="XM_014694228.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVX1"/>
    <dbReference type="GeneID" id="26239158"/>
    <dbReference type="KEGG" id="mbrn:26239158"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="263"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="442" mass="47802" checksum="1C67846F7D0BF8B9" modified="2021-02-10" version="1">MANPSLNFITFNQDHSCLAVGTSKGFRIYHTDPFSRIFSSDDGNIAIIEMLFSTSLVALILSPRHLIIQNTKRASVICELTFPSAVLAVRLNRKRLAVILEEEIYLYDISNMSLLHTITTSPNPSAICALSPSSENCFIAYPLPKPREDSDSRRPAHAPPQSTYVSPTSGEVLVFDTLTLKAVNVIEAHRSPLSCICLNSDGTLLATASETGTIIRVFSIPRGQKLYQFRRGTYPSTIYSMSFNLSSTLLCVSSTSDTVHIFRLGTPPGHTTPGGVPIETPSPPRQDRWSRARSYDDGDSPGNSATDSPRSDAAESGPGNAFPSGGQQGHRRQSGSFSNMLRRSSQIMGRGVAGVVGSYLPQTVTEMWEPLRDFAFIKIPKSGVSGLTPRATGSSIVGPLRSVVAMSSSSPQVMVVTSDGGFYVYNIDMENGGEGYLVKQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWK6</accession>
    <name>A0A7D5YWK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deubiquitination-protection protein dph1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dph1</name>
        <name evidence="4" type="ORF">G6M90_00g092370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541881.1">
        <property type="nucleotide sequence ID" value="XM_014686395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWK6"/>
    <dbReference type="GeneID" id="26245349"/>
    <dbReference type="KEGG" id="mbrn:26245349"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
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    </evidence>
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        </source>
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    <sequence length="441" mass="46987" checksum="723A153ACBD445E4" modified="2021-02-10" version="1">MAENAETSGDKHVTFKVKTSADSNHTITMAESATVSELKTKLAGQDFEHIPVERQRLIYSGRVMKNDETLGSYNIKQNNTIHMVKSAASNPTQQTSTSGSTPRAVPDNISAGTNPNDPLAGLTGARYAGHQINFPGMDMFGPDGGMGPPMDEERIQRMMSDPNVQQSMNEALNNPDFVNMLIESNPMLRNMPNAREIITSPFMRQMMSNPQMMGQAMRMQRNMRGGDSSFPAPGATDTTPDAAAGGNRSAGQANNNQPSNPFMNPFMMPGMMGGAAGGNNAMNLAQMLQSLNAMSPNPTAQATTTNASTTGNSQGTTPTAESREHQPATSDTGAEGAPQNSQTQNAANNPMAQLFALTGGNALNAHPNFDLLEQLSMNLGGMGPGMPGAAPDNRPPEERYAEQLRQLNDMGFYDFDRNVAALRRSGGSVQGAIEHLLSATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5YWL6_9HYPO</name>
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        </submittedName>
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        <name type="scientific">Metarhizium brunneum</name>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 5"/>
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            <begin position="1"/>
            <end position="101"/>
        </location>
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            <end position="230"/>
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    </feature>
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            <begin position="8"/>
            <end position="32"/>
        </location>
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            <begin position="33"/>
            <end position="52"/>
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            <begin position="75"/>
            <end position="90"/>
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            <begin position="143"/>
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            <dbReference type="EMBL" id="QLI72102.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="620" mass="69585" checksum="AE8424CD6AF84320" modified="2021-02-10" version="1">MWDVAWTDPKRELVGEHRGRKDKDRSVKDKSLSRNSVSTTSSKTSTHSTLSRLRARALRSSSKESPRQNIYPDSGPQTPDRSFNNRSPSVMSDAEQRQVSGRPILSCSDLQVEATSQNGFNSVGRSKFAAVKNTKNKGLAPETSATIESCARQSNDSDVFSTKRREKEEPKSTGYRNGNSKQPNGAGIWPQRPLDLQSPIRQSFVASPLVSPKSPSRVPGLSPALPQDEPVKVVPPMRSQIRLPPKPAQEFSPINDLSLWRSPREWSAATEMGNTVQMIETVTGLRAKELETTSFEMSPESWDLPTEVKQMAQAKPSTALSKLKASAENALSLEETQKINGEKKRWMLSVLHHLDCGNRHDSNDSSTLRNGLEILEQAKCRKILAAYDPRFSARYLAALWPENTIHHLSDNPLSSDSASNICAVYSPDAVSPFPGPLRNFDAAYSMTLPSLCRESDIPAVLNNINKCLRSGGVYHLLLIDPIPNTDALGKNMRAWFRNNLLQKLRQQSRCLSPSYIFPKALGESSLRGHGSTLTTTKFYANPQNICRRQDETDDEAKREREGKETRAELRSIVGRMLWREVWGEFVTSDTWWWEDPDCMRECLELGTFWEYYSIQAVKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWY9</accession>
    <name>A0A7D5YWY9_9HYPO</name>
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        <submittedName>
            <fullName evidence="9">Striatin Pro11</fullName>
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        <name evidence="9" type="primary">pro11</name>
        <name evidence="9" type="ORF">G6M90_00g031720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the WD repeat striatin family.</text>
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        <property type="protein sequence ID" value="QLI66525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687624.1"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Striatin_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="175"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="757"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="836" mass="89715" checksum="DACB4706C0E417F8" modified="2021-02-10" version="1">MGPTVGNGVGGMDMGMGMGMSMHPNGTNQPQATEYTLQGVMRFLQTEWHRHERDRNAWEIEKQEMRGRIAHLEGQARRADATQKALKKYVTILERKVKDQAAKLKGTAATEAAEAAKNDRAAKIQEKLRTSSDKYSVPGVEGIEVEKPDDDTQRIELKTFLDQCQSEFLYLMITPANPLPPRDSPPLPMIEDLREVEQFGMPPPQHMDRQYQMQRQNVNHVQDFNVMNARQQPPQNAGPQMQQPPANFAPKQELQPQPMLRSAGDNQQAMYGTPSDWSAPVSVTTRPVEENLPGPNHAAEALGGIQDATESRDKIPPNADPDGWDFPEGTFPEPGAVPQNPPSATNRPDTDVFPNAEYLPKSPNRVPSGGHRRKGSMSRRRSGEHELGLGSSQKSDSGNFKLRFGLRGHLDTVRTVIFSGGGSPGEPEICTAGDDGMIKRFHIPRLDHPGPFAGAASDLDVIANFTHRGHSGSVLSLTSWSPAPNFSTGGRAQGDGWIFSGGQDATIRVWERGRVDPKATLEGHTDAVWALCVLPTTLGAIFGTSSPYGNADRILLVSGAADGSVRIWSVSAPPQLSSPQPGSNRGMTGRGGRVRGNSMSSGSGFSNSPQASVASSSPFHYTLVHVVSRGDGSKGSPTCIAPLGTSGETFVVSYSDAAVIVYDTKTGEQVGSMDSMETYDGSVKTGVNAIVATTIGLDQGNQHHGSSLGGEEENAAGGPTGGRSMAGSGVEGTIISGHEDRFVRFFDANSGQCTYNMLAHPDAISSLSLSPDGRELVSAGHDASLRFWSLEKRSCTQEITSHRVMRGEGICSCVWSQDGRWVVSGGGDGVVKVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX42</accession>
    <name>A0A7D5YX42_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BGLR</name>
        <name evidence="2" type="ORF">G6M90_00g010530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549465.2">
        <property type="nucleotide sequence ID" value="XM_014693979.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX42"/>
    <dbReference type="GeneID" id="26238909"/>
    <dbReference type="KEGG" id="mbrn:26238909"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="90" mass="10201" checksum="FCA5709F7709D103" modified="2021-02-10" version="1">MTISTRGSMNPTSAQGPTRPRGWSARDFADEWLDGTRGIIKQMRKHCPELADFGFMAPSYDDRVSNLNATQVWGYGLDKYGSVKWYSVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYL7</accession>
    <name>A0A7D5YYL7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Microtubule integrity protein mal3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mal3</name>
        <name evidence="12" type="ORF">G6M90_00g016820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548849.2">
        <property type="nucleotide sequence ID" value="XM_014693363.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYL7"/>
    <dbReference type="GeneID" id="26238293"/>
    <dbReference type="KEGG" id="mbrn:26238293"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="244" mass="27210" checksum="A9B839A5700D88E1" modified="2021-02-10" version="1">MGESRQELIQWLNSLLQLNMTKVEQCGTGAALCQVFDSIYMDVPMSKVKFNANGEWAYVQNFKVLQNLFAKHQIDKPIPVEALIKCKMQDNLEFLQWTKKFWDLNFPDHDYDAVSRRKGGALPSSNSAAPRAPVSVGAARRGGATAAAAPRVAKAAGAGPNTVALQAENTTLKETVTGLERERDFYFSKLRDIELLIQQAVEEDPEIEKAEDGLVKQIQLILYSTEEGFEIPEEGEPLDDQETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYN1</accession>
    <name>A0A7D5YYN1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylB_3</name>
        <name evidence="8" type="ORF">G6M90_00g105540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987612.1">
        <property type="nucleotide sequence ID" value="XM_066131676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYN1"/>
    <dbReference type="GeneID" id="26245791"/>
    <dbReference type="KEGG" id="mbrn:26245791"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350:SF11">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43350">
        <property type="entry name" value="NAD-DEPENDENT ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="376" mass="39633" checksum="89F52CC9EA1064C4" modified="2021-02-10" version="1">MATTTALVLSEINAPFSFETVRLDALRPDEALVEIHASGICHTDLSCADGTLPAFAPAVLGHEGAGIVKEIGSQVRHVAVGDKVLLSFCHCQECAQCEDGHPAHCYSFKSLNFGGTRPDGSSAMRRQDDKGGQALYSRFFGQSSFSRHTVASVSSLVKVPDTTDLALFAPLGCGLQTGAGAVLNTLDVQPGSSVAVFGAGSVGMSAIMAAKMRRAKIIIAVDLQPSRLELASRLGATHTLLGSDPDIVAKIGELAPPNGVNYAVDCTGVPAVIETMIQALGSRGHAASVGAPTPGIKTGVDIFAHVIHGRRYSGCCEGDSIPSKIIPYLMDEYAKGNYPVDKLVTFYDFRDFQQAIDDTKRGIALKAVLVWKDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZE1</accession>
    <name>A0A7D5YZE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase psoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">psoC_0</name>
        <name evidence="1" type="ORF">G6M90_00g031290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543068.1">
        <property type="nucleotide sequence ID" value="XM_014687582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZE1"/>
    <dbReference type="GeneID" id="26243869"/>
    <dbReference type="KEGG" id="mbrn:26243869"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="273" mass="29915" checksum="F539770F864B2BE3" modified="2021-02-10" version="1">MDNFMNMTKKAGHTAELQRLVDLHAVFLDAMDGKLVLAPINLQEPGKRILDSGTADGIWLRDVRSPLSVQHEYFGSDIEPELFPETPDGITYFKHSFKDPWPEHLLNSLDLVHIRGSLAGSAPGKPIEVVKNLISMVKPGGWVQLMEMNAFQPPKGTLGPAMTDFAKMTSEVWTAIGVGNFANEMKHILEEAGLKNVQERRILCDIGKLAKPEMRARSANGITGPVAPLTAVARSVSTSFSAEQLDALPGRVKAELENEGARIEEIVVWGQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZJ4</accession>
    <name>A0A7D5YZJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ALP_2</name>
        <name evidence="10" type="ORF">G6M90_00g051030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545201.1">
        <property type="nucleotide sequence ID" value="XM_014689715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZJ4"/>
    <dbReference type="GeneID" id="26242542"/>
    <dbReference type="KEGG" id="mbrn:26242542"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028889314" evidence="8">
        <location>
            <begin position="17"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="69"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="325" mass="34531" checksum="5C7E3356BE3EA887" modified="2021-02-10" version="1">MKISILLAAFSCLVSAAPPAKPKTAAQSKAPWNLQAISHRSAPTRLNMFRNSDYLYTPWPKDKTLYAYVLDTGIRTTHQEFGGRAENFWTAFKTADNQDDFEDSSGHGTHVAGIIAAKTYGVAKQARVLSVKVFGPNGQVLTSQAILGFTFAMNDIIKKGRQNSAVINYSGGRKFSMAWNTIVERAFNRPNGPILTITSSGNDAKDAAGASPACADEAITVGSIRSDWSVAPSSNFGCKVNILAPGGKILSLSNTSDVATKTLSGTSMAAPHVAALALNAMAVFGKSSKDVLEFLTQTATKDKVKGDLKGSPNLLANNNNARQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZR7</accession>
    <name>A0A7D5YZR7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g029570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541214.1">
        <property type="nucleotide sequence ID" value="XM_014685728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZR7"/>
    <dbReference type="GeneID" id="26245849"/>
    <dbReference type="KEGG" id="mbrn:26245849"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="665"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="80232" checksum="AF329E1A948FBF49" modified="2021-02-10" version="1">MASGAITTGHEAHDALMDGHIEKRASVVAASELKPGEEVEDEEITDLFSSFPPLKGIEHEPNPLTARAVLVGIVLGSLVNASNVYLGLKTGFTFSATMFGAIFGYGIITLFTKLLPGVPLIGMKFGPQENSIIQASATGAGGMSGVFVAGLPAMYRLGLLSEDPKSDFPRILTITIICAFFGLFAAVPLRKFFIINVARELNLVFPTPTATALAIRSMHAVGSGANDAMRKIKALGFSFLGALTHIVVSQYANGILHEWHIFTWFYAWSGYTNWAINIESWGWYIQLTPAFFGSGILVGLNAALSWFLGTVAAWGLIGPLLVHYGECIGEQVGEGKWAELTNFNKLNDITKPGFVPSPRYWMLWPGVMVLLVYSLVEFVLHIRVVWDGAKYAFRSMASSINGGLKSKGKSIPFLEKQAAKLEEESSLLEDFAPPEQQVPGWIWGPGTLVMVVVSCLVCHFQFNMNAGLAVLACVLGILFAFLSIYGGAVTDTAPLTASSKASQLVYGGITKGNYSVADAQRINLIAGNIASGCADVSNSLVSDFRVGFLLKTPPKYQFYAQAVGALVSVFLAPGIFVLFMSAYPCVWRTDLPKEEVMRCPFKAPSVVAWQAVAQAVTAPEIPIPLSCTIFSIVMGVVAALQAVVKNFYLVGPREKYRDYLPNWMAVGVAWVLGADSGYANAILFGSVTAWWWKKYFGKNFDMYAFSVAAGLIAGEGLGGVVNAALTLGGVDGLKKGTFIALPGEDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z071</accession>
    <name>A0A7D5Z071_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeodomain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g024070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548173.1">
        <property type="nucleotide sequence ID" value="XM_014692687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z071"/>
    <dbReference type="GeneID" id="26237617"/>
    <dbReference type="KEGG" id="mbrn:26237617"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65676" checksum="96E3C3274D9125B6" modified="2021-02-10" version="1">MDPDEDVEEYSVDEENFASYESEAANAHLRGIASSYSAVNHSDSDSSYALSEANHVVSEDDDHLASRSLLKRSAEQAFNNLPFKRQKGVLNPEYLDLLNREIDDAAHQVCLEDIPEGKSDLRVDLPGSQVGLTFWSTVEKAHFFESVSRLGKYDLPGIATRIGSKSEIEVKQYVELLQTANDSRQSCLRRRSCLEPAEYPAAVEISQQCCHFQEEAADTVSVLQERREEQREKLKWGQKWDVTPSLARRLGHRGEESDDTSDMTLKFSELFHLSNWLQLSERVFMNSSVPGNNWNYIDHQRPSMWATAFDDFYSIAVSVTRRLVQTTLFISMSRIRAKKELVPTTRDIVRRKDVEAAVASLAMPHDSKSRWIKSARRLRLDVFNEPPDKDDEEAEEEPMTYEEVETILSGNNDGIEIQAPKDVILTDEASLDGDLKESDESRDNDTGIDSETEDDDDEKHEITREANEILLYSTPELKDIQAAKQALKLRITTERQQEAQAEMHDEYASYQAEIEMWDILKRKPLMELPKVEDPGPVHRSILSVDNVYPLGRDWASKLEYYGEWETLDTARHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z138</accession>
    <name>A0A7D5Z138_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g007840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549724.1">
        <property type="nucleotide sequence ID" value="XM_014694238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z138"/>
    <dbReference type="GeneID" id="26239168"/>
    <dbReference type="KEGG" id="mbrn:26239168"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="336" mass="37537" checksum="2167F4D17FB6B795" modified="2021-02-10" version="1">MEKRTPLTDVGSLDASNHETPSQTLTPPPYSGPSSSGTEGQVDDGIPTEPLKGILRYPGLPKLDYKLYSPPLFKLSSDSITLSSKAEYLSSNAAALVSLIRAQSTVPPKPQIHVRGSRGRRIDFDIKLNLMTLLVPDDERLRMDYIRCVGEGELAHRGGARPDVLPEVGEGGLEEWCRRFVQDTATVKTFSLDRVVANLDVGWIEGQLRSLIATLKYRGAVDVTFLVTHSRVLVQNPDRVNQFFTNVTSLFSGKNKYEVIKSVWPFATTKNGEPGRRCIVQSEEVWWREWKDPIRYAISQKRQGWVTVEDKLEAVMEGKGNQTESVDWGPDQYGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z183</accession>
    <name>A0A7D5Z183_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aurovertin biosynthesis cluster transcription factor aurF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aurF_0</name>
        <name evidence="2" type="ORF">G6M90_00g030130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539726.2">
        <property type="nucleotide sequence ID" value="XM_014684240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z183"/>
    <dbReference type="GeneID" id="26247483"/>
    <dbReference type="KEGG" id="mbrn:26247483"/>
    <dbReference type="OrthoDB" id="4468425at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="509" mass="55671" checksum="363FE98FFF38A955" modified="2021-02-10" version="1">MECSAQNESLSTSPPILDNAYYFIEATRSLLDEGDVTALDTLASRLSPFRIQYRSVVEGDIISVKPVLVLEHEQSPIKGRWKSTESTGFDVGVFQDNCSTLVSALNSGTTNTDPYKPGLTTPAMTNNILVDYEANSHENAIVYAQIPRYGTGLGLGTRNSLATTNVDLSQAHNAGLGLADTGHAVHETTDSSSKDSSGDCTLPLPDFDLIDFDGCAYLTGGGMGTSCHNQPTEMTHIMQNTRSLSSAGPPGDSIFVEFDSSLQTSGTVGNVEPRAPRAENNDALSTSGDTPISDFDSPEGCLVGDTHSPVSNTLYDSVKGTPSASDAALLKVNYALRVCIRADYVEFLETNLPRWVKHGIWRTVWPPSKAKGAHGYESLQKAYWNICRLDRQMGDDAIRSRMAMVMLHLEYEKACLTWKSRTSTKWASANSQRKSEMRAKFHDRKRKNTAVTAKIIKDIERAIKNSRTGLLDILNKVNPIAQSLFLNHGYESHNLQIKLPLLLEQPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1N7</accession>
    <name>A0A7D5Z1N7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g041550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986622.1">
        <property type="nucleotide sequence ID" value="XM_066130284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1N7"/>
    <dbReference type="GeneID" id="90967669"/>
    <dbReference type="KEGG" id="mbrn:90967669"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="41" mass="4270" checksum="76A8905826D6083B" modified="2021-02-10" version="1">MPADASPAAADRRVLPDSVPNITELLSILIYGEYPDAAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z292</accession>
    <name>A0A7D5Z292_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ankrd28_0</name>
        <name evidence="5" type="ORF">G6M90_00g067810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540538.2">
        <property type="nucleotide sequence ID" value="XM_014685052.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26246645"/>
    <dbReference type="KEGG" id="mbrn:26246645"/>
    <dbReference type="OrthoDB" id="4938465at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="246"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1079"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1439"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1505"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1574"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1796" mass="200374" checksum="C6E9AC81751C2262" modified="2021-02-10" version="1">MSSSSGWSDMKRKESSLHVAIVRGIGEGPKGWDREKVVKWVKKSSYRRYGAPEITEFANTLDFDGGITPESIKEAAVRLLERMRKEIEESGVFIETPHRATEFESWESISTKLLLRRKDQGHCPSSTASEQLGNTLMKLSKSFQVMARIYPIVNLYECINEEALRSTPLAFSKDTTTMGVPGEVCDRLRESKNRGKYVKFFTLMDLWEEGQKDTYFRCLMDLSRADSHHSLGEHVHLSSCTPDKFNWILDRDACKNWIGPACRPLWLYGMAKSDVAASMDVLERKARATFPDANVIKYSFDAQDDRCRSTYGMLASLSHQLLTLKPGLFEHVRSLYHACDMFLEVEFKIEHLWAFLRSLLSCPPKRHGVIFCFINMIDECDPCSNKFLKDLLLLASSETSAGGFRLAVTSHKAPDSDVEFAAHAINVIQERHEDPDEKKKEIESVVARETRLLFEARPELEKLDGIINEKLSAVDDVFNISLIAKLLQARLPHWGDAELETQLNALPPTTFEIYRHFLDSIPADNQSWARDVLSWIVHAFQPLKVTELALAMALQDDTLSILELQRLPQGHIESKIKNVFGNLIQIQHDNVFFIDSSFRDFLIQTQSSCQERSLKLVNHANCARLCLRYLSLVTSATEESKPIFDKKNLFTPSEGIEYGFLDYAGQYWFRHYNLAKHDAFPDLQDEACAFLERPKSDIMWCKLKVDYSTWQRGNPAHVAISLGCNDVARTLLEKPEWNAEVLDHTQGLRLTTTRETAIDFLWEAGARHGVILYAAAMRGRDELVDQILKDQAQVEMGKEYISPYGRTALHQASSLGYHAVVRKLLNAGYNANVTNDELLVPLQLASRFGHVDVIEALLTGKEKADDENMDTDTHPACAAVVGKSPWLVQESLMMAIDSQQHDAIKKLLDRGAKLEKNPKALSHAVASGREDIVGLILRYYEKLPANILHEAMATRGENNYTPLGLAARGGYMDVVRQLLDKMESRMDTTETEDMKKKSPRDMPLHLAAEGGHAHVLKALIEWQWPQDSEYRDKSNIRAANSSGQAPIHLAVLGGNASLVVQLCLEHQTQKVSLRLLNSRLRSPLHVACDCGFVDMVDILLEHGGWYGEADENGDTPLLLGCAAGDLQTVKRLLTHDSNLLIKNLQGRSALHHAAASGEPDVVQELLRASSDANDIRIYTNAKDKSGSTPLHLAAVAGNVEVMDILLDEMADITQVDGSGHDVLYLASRHGHANVVTFLIQESRKGIEGDDGDTFHFGGDIFQFVQEMLSYFPHNLPVAEETDIAVEIGPRENCAMVLANLTSLANQWTPSQYGITLHLAAKGGIVSVVDQVLLKGQDPNYMDTMEKTALMYAAESGCSRVVERLLRVPNIDQDCQDTFGYSAISYAAESGHLEVVKMLASGRKSAIDAQTLTAASRCMANMKGSSIMTFFLDNDIDGSLVDSSLRIAVSEGFVEVVSLLVGRGANVNTTYESTSTPLHKAAGRGNVGICKILLEAGATVDSETKDKETPLILAVSRGHQEVSEQLLHSGADPLAATSSGKTPYHEAICAGPEIFKAVLSRVLELNKSAHTKDAQNRSPVLLAAAQGTQEAFMALIDIEGADVNEKDKNGYTPLCHAIFRQQAVIVETLLKKPELKRSMSAKDMLQRAAGFEEDKIMKLLIQNGIDRDLEFDDLFELAMESENLYLVEIVLQTPHDGIRLDKHRWSLECLKHVLMDPEYKREHMIRNSDTDLKPPLGWCHQGEVDVERAPEDAWGFPGPIFPNLRLENGQRLRADHPIPPVGKFKFEVHLVDATLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2P0</accession>
    <name>A0A7D5Z2P0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L21-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL21</name>
        <name evidence="4" type="ORF">G6M90_00g089340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541597.1">
        <property type="nucleotide sequence ID" value="XM_014686111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2P0"/>
    <dbReference type="GeneID" id="26245460"/>
    <dbReference type="KEGG" id="mbrn:26245460"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="160" mass="18152" checksum="A47A9148C43DEA0A" modified="2021-02-10" version="1">MGHSYGKRAGTRYAFSRNFRQKGMIALNTYLKTYRVGDIVDVKVNGAVQKGMPYKVYHGKTGVVYNVTKSSVGVIIYKKVWHRYIEKRINVRIEHVQPSRSREDFLKRVKSNAEAKKKAAADGVTVQVKRLPALPREARTVSLTDNPPETVTPLPYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z364</accession>
    <name>A0A7D5Z364_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539666.1">
        <property type="nucleotide sequence ID" value="XM_014684180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z364"/>
    <dbReference type="GeneID" id="26247577"/>
    <dbReference type="KEGG" id="mbrn:26247577"/>
    <dbReference type="OrthoDB" id="4956609at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="58902" checksum="528BB095BF26CB6F" modified="2021-02-10" version="1">MAGPLRFKSYDPASRKPRKPKRIASAAPRKHHGDNTETRHDGAASQSVAEGYLEMNNQKDLMTVNLTDLDVCDDIESVRQLVETRIASTLCGNEVRGHASTSLSPTPQLDLSTETPETHPGDIQNQDSVLMAEADPHAQVDGIAPTLTTPASLLAAMDLTVNGANDVALAAMRQPRAATTTQLPDLSRPGAHRRGGGGVASISSPALSISPSISEDTGSPYLESLFDDDTGFQRWLDTEQQQVSAPGSERLTRPLEDSGYDGSSEDQQEAKRPKLSSTTECDTLLHEPDVCESPLAPADSTVTAHDASHQVLPTRHIEGNPISPFASIRSGATTCFPRRPAVKFATRGDVMTSQSHIDTLWSPPPMGLPAAVRLSGGQETDQNGQCKSCAIFRAALFEALSLLHHPSHTVVSNTPQHAKPRSNVLKRRYSMRKRPMPLENGCEDSDDNTVGYIDKHCNESDDGGILCDKNEDDDSLSDTDKSRDVSVKRRRWSDLEERRLRAWKRENKSESWIASKLNRTVSAVKQQWRKMSEEKSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3D7</accession>
    <name>A0A7D5Z3D7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g074740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545593.2">
        <property type="nucleotide sequence ID" value="XM_014690107.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3D7"/>
    <dbReference type="GeneID" id="26241626"/>
    <dbReference type="KEGG" id="mbrn:26241626"/>
    <dbReference type="OrthoDB" id="5429395at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="383"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="462"/>
            <end position="496"/>
        </location>
    </feature>
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        </location>
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            <begin position="216"/>
            <end position="227"/>
        </location>
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            <begin position="242"/>
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        </location>
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        </location>
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        <location>
            <begin position="508"/>
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        </location>
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        <location>
            <begin position="532"/>
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            <begin position="676"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF15456"/>
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        <source>
            <dbReference type="EMBL" id="QLI70263.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
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</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
        </source>
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    </dbReference>
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    </dbReference>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI71565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="147" mass="16716" checksum="8EB699A5CBB2ACAA" modified="2021-02-10" version="1">MWKPPSPTETPRSPSVDESALGAMSATRTKNPGRRFAQVVKLKKECVDQYKACHAAVWPEVAQQIKQCGIEDYSIFYDDITGLLFGTYKYIGYDFAGDMERMAENPKVREWWKMTDSFQESVVPGAVSSEAGVPSWWKPMEEVFYQA</sequence>
</entry>
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    <accession>A0A7D5Z3K7</accession>
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        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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            <begin position="361"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="EMBL" id="QLI68267.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="499" mass="54709" checksum="D2CAB9C5409A4320" modified="2021-02-10" version="1">MSNVSVGSANAAFVTPATGVLDAYNRRNNMHDASREFYKLLDDLQSPAVRDRLKRAKIGIAQTIEAFEKGYETDYVVIQLAMSMSPLSFRAVLSGTVAWQAAKTTSLDWYSAAGPGVYAVGIGVNGRGGSFLSAQEIRRLAEGIDRYSAGYDALQTAAGQRTSSQRQDVRYLRSVDNAISNCVASAKGGRSIDNPSEQQRALLFSERLRERAQAIESVDPTGQTIQIQSPLYVGCSEKLEQRTRDYVAPVNLGNINKLLALTLNVLKMMNLPSTLYVRPVIRIWERHQLPYAERLVATLAESLVAQNGFNAREAGGQACPFNPNAFQTAKSVVFSVKPYLKRHIDGVDTVLKDRLKFIQEVKRLSQYLSDLQQEIDGTRQQLRSLMALKPIGWTAGIAMLQTKLQKLCQQTDMLVDWKVRMQAVIGLQNAMLPPPPSAGHQSADSQPPLSATEVRWVPATPVAGQGRRPLPLSSSSVVTVIPQTSDSSSLPAIDEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4P9</accession>
    <name>A0A7D5Z4P9_9HYPO</name>
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        <submittedName>
            <fullName evidence="5">PAB1-binding protein 2</fullName>
        </submittedName>
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        <name evidence="5" type="primary">PBP2</name>
        <name evidence="5" type="ORF">G6M90_00g098340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Hypocreomycetidae</taxon>
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        </lineage>
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    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_066131541.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
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    </dbReference>
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    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
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        <location>
            <begin position="386"/>
            <end position="456"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
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        <location>
            <begin position="287"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="365"/>
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        </location>
    </feature>
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        <location>
            <begin position="26"/>
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        </location>
    </feature>
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        <location>
            <begin position="54"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="48748" checksum="BF918DA796B6D05C" modified="2021-02-10" version="1">MSASPPQPTSTKRPLEEASSPSRATDQPDAKRPALDKVIKNDEEREASESTIDVADKNGDEDGSKSDQPDVPVTDGGSDTKAAGASNVTASSDAAANSAAAHDETSWIHIRAVISSPEAATIIGKGGENVSNIRKMSNAKCTVSDYQKGAVERILTVSGIVDAVAKAFGLIIRTLNNEPLGEASTASSKTYPLRLLIPHILIGSIIGKGGARIREIQEASGARLNASDSCLPMSSERSLVVMGVADAVHIATYYVGSTLLEQLNERFGGPAASAYATRSGAPAGSIPGGMQVVPYSPQPASGHYGRPENYGRHQDRRAHHMPPATYPPHYPHNAAPPNPAMPMQYGGQQAAYGGAPHATQHMPPHVGPQPHGGPQGPPMQHGMPGGPLTQQIFIPNDMVGAIIGKGGQKINEIRQISGSVIKINEPQDNSNERLVTITGTEECNRMALYMLYSRLESEKHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z654</accession>
    <name>A0A7D5Z654_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA-processing protein EBP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EBP2</name>
        <name evidence="7" type="ORF">G6M90_00g095620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546768.1">
        <property type="nucleotide sequence ID" value="XM_014691282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z654"/>
    <dbReference type="GeneID" id="26241191"/>
    <dbReference type="KEGG" id="mbrn:26241191"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="406" mass="44803" checksum="51BF84D004C4D0EB" modified="2021-02-10" version="1">MVTKSRLRLAIAAEKGIDFKKLKEKKKHKENLKRKGAATELGGVPAARRDEGDEDDDALDGHVDVESEGDDIEEMNIGAVDETDTSDSEIELEEKVSRHASGKRTNNESKQEDEEGDDDSEEDEEDIPISDLEDLDDEDKEDLIPHTRLTINNTSALQAALDRISIPTDKSATFASHQSIVSSVNTADSIPDISDDLQRELAFYSQCLDAAKEGRTRLLAEGVPFSRPKDYFAEMVKEDAHMEKVKAKLIEEASAKKAAAEARKLRDLKKFGKQVQVAKLQERQKAKRETLEKIKTLKRKRQESGNDMNTNEADLFDVSVDNELASHAQSMGSSRGGPSGKGVNAKRQKKNEKYGFGGKKRHAKSGDALSSGDLSSFNTKKMKAGSRGKPKASRPGKSRRKAMSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z691</accession>
    <name>A0A7D5Z691_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">A-kinase anchor protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Akap5</name>
        <name evidence="1" type="ORF">G6M90_00g068130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540569.2">
        <property type="nucleotide sequence ID" value="XM_014685083.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z691"/>
    <dbReference type="GeneID" id="26246676"/>
    <dbReference type="KEGG" id="mbrn:26246676"/>
    <dbReference type="OrthoDB" id="8926660at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="435" mass="49978" checksum="94534A8EF3C9A4A3" modified="2021-02-10" version="1">MSYSRIRYRRQGVSRDESLVSHEQDLRFKVSDSGEESYVGFDEETNLNHDEATYSDHVESLIPSVQNLGFNIPEVNEESYLGPDEATSSNHNEATYSNHDQATYSNHDQATYSNHDQATYSNHDQATYSNHDQATYSNHDQATYSNHDQATYSNHDQATYSNHDQATYSNHDQATYSNHNEATYSNHDEATYLGSDEKTHLDHDEETNPSDGGQDDPRCYGICPGTLNPNAISNEHYRRGNVNFDYIKAYWPQTIPRHYAWTGKYPVDERFALARVEDKIGINLKDIFDHGSWVPFNGISRKGIAPYIATITYSTPPITLSYAILRRNVSRPVCVFGFKLHLDGQNQKFNPILESRFYMVKAGGGQGGSTKTLDFLGFQKPPEREPSAKFWEFEWWVPKYICCRDDFNLHFRPDEVDARSTESSRRAGHRQRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6A5</accession>
    <name>A0A7D5Z6A5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter asaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">asaE_10</name>
        <name evidence="10" type="ORF">G6M90_00g107900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544054.1">
        <property type="nucleotide sequence ID" value="XM_014688568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6A5"/>
    <dbReference type="GeneID" id="26243441"/>
    <dbReference type="KEGG" id="mbrn:26243441"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="92"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="485" mass="51716" checksum="E4B2ACDEBFAE3DFB" modified="2021-02-10" version="1">MTEKLDQTAQVNKTLNGSDSGLDALAPTPSHCTQKLAESDAAMVQGEWIAETGEQVSRQVSRQASRRDVETASQELSDSTDDDDDFPDGGLEAWLVVLGAWCVSFCSYGWINSVGTFQEYYQTGPLKEYTASQIAWIPSMQIFLMSFLSPFTGRIFDNHGPRSLLLVGSFLHVFGLMMASLSSEYYQFMLSQGLCSAIGVSASFLAAIGSVSGWFKKRRGTAFGIFATGSSLGGVVFPIMLSNLIKTVGYGWAMRSAAFIILALLIVANLTIKARHVNGRQALSKELLARPFHEKTFLLLLIGLSLVPFGLYTPINFIPTVAKAEGMRDSLAQNLIAFYNAASLIGRAGSGLLADRFGLFNIFSLACYGAGIFIMVLWIPGGGNDAATVAFSLLFGLFSGAYIALLGALVARISPIEEVGYRNGIGQLFGAVGGLVTAPIAGAILQGPGGEIGLKAFAGAFMIVGTTGIVAARISQTGFKLWVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6R5</accession>
    <name>A0A7D5Z6R5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g076610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545441.1">
        <property type="nucleotide sequence ID" value="XM_014689955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6R5"/>
    <dbReference type="GeneID" id="26241474"/>
    <dbReference type="KEGG" id="mbrn:26241474"/>
    <dbReference type="OrthoDB" id="4940277at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI70627.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="30759" checksum="DCF55FF0D6A726B4" modified="2021-02-10" version="1">MEELRCAAVISNLEGIKDVPFWIDDVAKPVSLPSLDRRVGRLEAAVGITPPPPVTEPSWNGLVWRIWRLRNRMPKEAIREFDAESHVAGADFRSMMPDAAEISLQDVGNALASIKMPGGRIPFAPELDDADLSLSYMLQRLCHMAGRKNLYLDAVPVGLVDVYVLAVRLSLYVEAGGARKTTRPPLWPRPAATVPARPAKPCCDCCGCYCHSNKVVPMPPPPGRRWARTRGRSEASSVSEREVPRKRRGWLARLCFWRRSVGDYESITSRGSSTIVD</sequence>
</entry>
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            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="QLI70726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="162" mass="18972" checksum="AD9141AD94AF1746" modified="2021-02-10" version="1">MAAQYTELLRATGVDYLRTDAEEEDQTHLETMQAFDTIELDEEELVLAREAAKQRFNRTQVRPNLYSYDWSDAHGAFWDRVKKRLTTRLDAWGASLDKVQTKAVSNEFEMEILIETPTPITRVHRRMWRHNLGYSLLQPGTAIGTRKEEIYLLLAHFQLDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z850</accession>
    <name>A0A7D5Z850_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 6</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g059600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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            <begin position="12"/>
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            <begin position="38"/>
            <end position="48"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35036" checksum="9D57D02FC1549BD8" modified="2021-02-10" version="1">MGWFPSIFGSDKPSDPLSKLDPKLREFLEKESPVKYTPNRSPTSTSATPERHTDEAQKADKTEPEHNKSAVPSESLYQDGRYAHLWKNYRPLAQIEADAASDHDKLMDVLEGFKERKAAIGRAALENCAIQQEEWVNCMKNGSWEDQLQMCRNQVRRFERCYTLQSRFLRALGYGSVAGRPSQVDEDIQMHADTLYDRMITHEAAVEQAKKDGTPIPIFDPALPKASATKVIPTQELEKTWKEKLDKLPEEERVVEEAALRADLQAKSDVAKNVKQIWASQKEEREARKAGGQATFGDTLSAIFGRGGGTK</sequence>
</entry>
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    <accession>A0A7D5Z8C6</accession>
    <name>A0A7D5Z8C6_9HYPO</name>
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            <taxon>Eukaryota</taxon>
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF17">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A7D5Z8E9</accession>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <location>
            <begin position="9"/>
            <end position="19"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="303" mass="31389" checksum="98EC9931F18502E6" modified="2021-02-10" version="1">MASRNPFESNDHDDPDAHAPEAVATLSPITPQSNLENELQAKYQSARSSERQPPPPRPADSEKEVVNLEHDSALKHVVPLELTSEYPETAAVASPQTPRATHADTLKARSMSDAAPEALPPGGQGGPRILGMSKNAFLILVAVTIIVVAAAVGGGVGGAVASSKKPNATPASASSSTPASSSAATAPSQTVQFLSNQTWPQGYAFAFQGFSRPGFTGAATRILTGDGGASAAADFDFGVRSYVWVPNIGNCCVNFCANATGLGYVGYRCTPVRRNESSEAVARAFVWCDDTHSDAVAEAKGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5Z8X8_9HYPO</name>
    <protein>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688994.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26242892"/>
    <dbReference type="KEGG" id="mbrn:26242892"/>
    <dbReference type="OrthoDB" id="4939505at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028891992" description="Cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18209" checksum="D509D56469C27249" modified="2021-02-10" version="1">MQLKLLCLVTLAASVFAADRLAASLNIIAHDYDKLNQGITAWPGDYESCVPLVSEADAITKALTTVKPPVTISPPDAATVKERQQAAQALCKIIDAYLKIAIEVKHKVYMSQPSVKPMVVAAIEELKAAFLALSTACLPVMTDTQSRDAFDSINKDMLLVEKLYKEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA82</accession>
    <name>A0A7D5ZA82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MEP3</name>
        <name evidence="11" type="ORF">G6M90_00g101340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546212.1">
        <property type="nucleotide sequence ID" value="XM_014690726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA82"/>
    <dbReference type="GeneID" id="26240635"/>
    <dbReference type="KEGG" id="mbrn:26240635"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="38"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="516" mass="56136" checksum="34DF38A4FE55FAAE" modified="2021-02-10" version="1">MSYAHLGAPAVFNGTNDDIGGDSRTENLNQWYQAGDQAFIIISSCLVLLMVPGIAFLYSGLARRKSALSMLWVVMMSFSVIVFQWYFWGYSLAFGQTSNNGFIGDLKHFGLINVWATPSVGSPLIPALLFSFYEMMFCAVTAALTVGAVAERGRVIPGMVFTFFWATLVYCPLAYWVWNANGWGYKNGVLDYAGGVPVEIGSGVSALAYSWVLGRRNERMMMNFRPHNISLITLGTMFLWFGWLGFNGGSAFGANLRAVMACWNSCLTAMFAAMTWCLLDFRLAKKWSMVGWCSGTISGLVAATPASGFIDPWASIALGVVAGVCCNFGTKIKFLVRIDDSLDVFAEHGIGGMVGLIFNAFFATGKVIGLDGVNTGASGGFIDGNYKLLGWQIAAIVAASAYAFVMSAIIAKIIDVVPGLKLRASEEAELLGMDDDQHGEFSYDYVEVRRDFLAWSPPSGEPAHDGEMIEPQHGIQEHASMVRPMSVSDGPVEKKSSASSVQFDRDRAVLDNEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCB3</accession>
    <name>A0A7D5ZCB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Secreted beta-glucosidase sun1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sun1</name>
        <name evidence="13" type="ORF">G6M90_00g109830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543873.1">
        <property type="nucleotide sequence ID" value="XM_014688387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCB3"/>
    <dbReference type="GeneID" id="26243260"/>
    <dbReference type="KEGG" id="mbrn:26243260"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028977692" evidence="12">
        <location>
            <begin position="20"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI74568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="438" mass="46566" checksum="E48DA5AB8409F4D6" modified="2021-02-10" version="1">MRNLVHVAIAATLAIEVAANSHQHLHHHAKKDVASKVERRAADGIVWVPATETVYILGGEKISMEEALAGLNNGDFVIAGESTPIFTPPLAQPPKPTTTTSLQDLGAQFLEKSSSAASLPNPTTTSQPPPPKSTQAPKPSPSPSTPPSGGIGLDSKFPSGQIDCSKFPSDYGAVPLDYLKMGGWSGIQFCPDYSMGKSKSINNIVTGIHNDECTKGAMCSYACPPGYQKSQWPEAQGETGQSIGGLYCNEGGKLELTRKSNPVLCEPGAGGVSIINELDEVVSTCRTDYPGTESMTFPAEAMPGKSVVLTNPDSSTYFFWKNLPTTAQYYVNNKGLAAKDACLWNCPCDENKSQEKKTCGNWAPINIGVGQANDTNTYISIFQNAPTSSAKLNFNIKITIDGNTKCAYENGNFIGEGNGNGCTVTKSESAKAVIRYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCB8</accession>
    <name>A0A7D5ZCB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb-like DNA-binding protein myb-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rca-1</name>
        <name evidence="4" type="ORF">G6M90_00g088670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542248.1">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
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            <begin position="2"/>
            <end position="53"/>
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        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="58"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="183"/>
            <end position="201"/>
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            <begin position="241"/>
            <end position="252"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35900" checksum="0B83A0E81DABCA12" modified="2021-02-10" version="1">MEPRQRRGPWSNTEDRFLLSLIGNRGPLNWVRIAQVLGSRTPKQCRERYHQNLKPSLNHDPITPEEGAKIEYLVETVGKRWAEIARRLDGRSDNAVKNWWNGSQNRKKRSERRRRASNSTSAAQSPSSTSSSPLPSFDHGMQRAPLSIMSPILPAPFSNNLRSPMSGSRSRIGSLVDGPLPSPCSSEPSDLDSSAHYTTSPADRPRSLYSQIPQVELPPLRGWPEPVPAESQLPRISPMGRLDEGRFGRDFVRLPPLSSPSEPMTTPALPTLQKEEEGKDLRHEQSQREPQLPPRHLGASDSSAEEASNDTGYKMRLASLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPH4</accession>
    <name>A0A7D5UPH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CGI121</name>
        <name evidence="9" type="ORF">G6M90_00g029060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI63574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685775.1"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="199" mass="21881" checksum="A8EAB756BA2ABB1A" modified="2021-02-10" version="1">MTLEALSIEHIPPSYKVHLGLFQNVHNADFLHQQLLSRNTDFEYAFVDASVVVSRRQLLSAIFKAVNAATNGSLKTPNVHSEIVVSLNPSNNITDSYRRFGISPTTKNLAVVKVTYSPESSESNSAASKDSIQAHLAEHVKGTAVDVTDANIAATTDISKVRKYYKLNGLDWLEAIRDEQKKRAELDTLVVSAMALRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQJ0</accession>
    <name>A0A7D5UQJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase CHFR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">chfr</name>
        <name evidence="12" type="ORF">G6M90_00g014940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3RF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693544.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQJ0"/>
    <dbReference type="GeneID" id="26238474"/>
    <dbReference type="KEGG" id="mbrn:26238474"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="869"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="428"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="931" mass="103406" checksum="0A4C4D7BE36DA8BD" modified="2021-02-10" version="1">MDSRKPSLDLEKELTCSICTELLYQPLTLLDCLHTFCGACLKEWFRFQAAKAEKAPTPPAPGEAIFTCPSCRSPVRDTRHNATVVTLLDMYVAANPAKARSDVDKEEMQAKYKPGDQVLPKINTRERTAEERRADEEDRRLIDEVREMSLREATPGGLSQRDRRRRQRQTQSVDGRSRSSRDQSSSSRRRGTEHTTRNSRSDDSSRPGSDHSASDREQRRRRRRSVSRQRQVEHQTSLRSLIGSSEMSERDIEREIEDFARQIQEEGLLDGLDLDNIDLSRDDDLSRRITEAYRRRQRERSRNESSRQPTSSSNNAASRNSEGAQTDARLRAPEGGSRSRASSRSTNGGGQAEDRSRPPPTGSTNLEVRDAARRPRRRTASGGRSATTPVFSSTAETRPAARSSTDLGLRSRTSDPTAPRHSFSEGRSSSTPSVPASSQAPIELPASASSNSNIASFANRVPQWNPNIADPSPATTHELPAAQISRPHLPAELAIVHSAVSSPMSSPSATSGHRRTKSQLFPEPSISCAKCNKQHIEYELHYNCGICTGGQWNICLDCYRAGKGCQYWFGFGYGAWKKWENLRQKGDDSLAKPHMLTACRYLPPPSTPGGADGRKTLTTDDPRGRLETGTFCARCFTWTNDCYWRCDVCNEGDWGFCNNCVNQGNSCTHPLLPLTHEALQAASRPHSPRSTGRPPAATVYTGPQAANIGPFKPLTFRTRCDICQDPISPSHVRYHCFSCKSALIPEAPPGDYDICSSCYNSLVSTGQISMENGHSGWRRCLRGHKMAVIGFADGKIGQWRFIERDIVGGRVLRSEAFESPERNGQELQKSSWKNGDEKLERLVTKDVSATAPSTVGSLSFTQTFPLDGGTGMRANARWAWYPQAGSDDELLFPKGAEIREIEDVNGDWFFGTYMGAKGLFPAPYVRLGQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR95</accession>
    <name>A0A7D5UR95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g009400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549573.1">
        <property type="nucleotide sequence ID" value="XM_014694087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR95"/>
    <dbReference type="GeneID" id="26239017"/>
    <dbReference type="KEGG" id="mbrn:26239017"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="246"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="338" mass="38293" checksum="CCA7A4E27B82BCB6" modified="2021-02-10" version="1">MAMNPEREKMLRDASAKEIELPNPPRVKCIRITGSNVVALKDTNAARPKPDRPDATKTSATTSRKRSRDLLEQENLGDVAFDYRLRRQHAALFPLPPPPSHHTTYLTSLLQGWLLRLTLEPKPTKKSVPAVSTHTDQITSVGLLVNELMRRMGLPVLRLPTLNEKCLSASQKYDIARQVRKFVTQLRKTPRQNAQLGSIASGKCSLMLDKHQNNTHWAVRLNPTHSMFIAFLMSSFYATVPSSVGAALAEQLRRESPLVMSHGDICPKNIIVDKSQIIAIMGWDCAGWYPDWWEYVKFFEARTSDKNSDWYEYASEIFCEEFPAELAAYQGVVRCQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URC1</accession>
    <name>A0A7D5URC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g023280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548227.1">
        <property type="nucleotide sequence ID" value="XM_014692741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URC1"/>
    <dbReference type="GeneID" id="26237671"/>
    <dbReference type="KEGG" id="mbrn:26237671"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="107" mass="10216" checksum="19DEFE85C8302C9E" modified="2021-02-10" version="1">MADQKATSAVNNATDNVSNQANNAGDQVQGGLGFLTSTLGNTVGGVSRTVGGVTGAATKGVGDTVNSVGGDTVRPVGDGITSLGGGLQGGINSVAGGVENAGNWNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URM8</accession>
    <name>A0A7D5URM8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein arg-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arg-6_0</name>
        <name evidence="4" type="ORF">G6M90_00g020600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985868.1">
        <property type="nucleotide sequence ID" value="XM_066129859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URM8"/>
    <dbReference type="GeneID" id="90967486"/>
    <dbReference type="KEGG" id="mbrn:90967486"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="179" mass="19823" checksum="ED771791BBE112E2" modified="2021-02-10" version="1">MSGNQRSRKQIVFTAHIATIISNLLSHVEATVLALKKALLESQNNLDTEATDAEATVDRFLEFLKVNPFTAYYDENISGLAIILPPSADKPTATIASLTITKFGWLSNLAENMRSAIKTDNPSLCWRVSEEDENLVWFFEKADGSFKHNGGVLFYYGSDFDADGLDSFSTTLPAIHTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US24</accession>
    <name>A0A7D5US24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g029550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985941.1">
        <property type="nucleotide sequence ID" value="XM_066130034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US24"/>
    <dbReference type="GeneID" id="26245851"/>
    <dbReference type="KEGG" id="mbrn:26245851"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="394" mass="43870" checksum="FFB72341D9C5B644" modified="2021-02-10" version="1">MSSLAAESWSWYGLTWLVVATRMASQVLLRGSVKKLKLDDFLMVMAMCTDTVLIIATNIIATTNSNLIDPNHPASLSPEDIRQREFGSKMVLLAEQMQCVTIWLVKACLLLMYHRLTLSLKGNLVVKIVACYVAVGFVLMEILYLGVWCRPFSQYWAVPPDSTQCSAATNHLITNAVLNISSDIMIILIPMPVFLQSRLKWRKKLILVGVFALGGFTILSAILNKFYSFNEPFGSAWTFWYIRESSTAIIVANLPLTWTVFRRLFHLRSFDNSEYSSKTRSGQPSSTLRSHGQAHGRTPNRSYIRQGDANDDDLAGSQEEITKGHGISLRIYQRHDVQISSEPVTNHHARQLSNESLPDGLTTTIKGGASGSFLLDAETASDKSYPAVKVNSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USC3</accession>
    <name>A0A7D5USC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g007430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986028.1">
        <property type="nucleotide sequence ID" value="XM_066129629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USC3"/>
    <dbReference type="GeneID" id="26239211"/>
    <dbReference type="KEGG" id="mbrn:26239211"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="71" mass="7750" checksum="3AE4A51970EF924E" modified="2021-02-10" version="1">MPGYIVTCKDDATEDQIKAAKQHALDQGGKITHEYTLIKGFAVSFPNDAITTLESNEHVKAVELDGEVKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USQ8</accession>
    <name>A0A7D5USQ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">OLE1</name>
        <name evidence="19" type="ORF">G6M90_00g022110</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548342.1">
        <property type="nucleotide sequence ID" value="XM_014692856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USQ8"/>
    <dbReference type="GeneID" id="26237786"/>
    <dbReference type="KEGG" id="mbrn:26237786"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="345"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI65718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="53308" checksum="D51E47703F22C2E8" modified="2021-02-10" version="1">MSSSSSAVQAKAFPDGTTDYVPLRGKKADASKVHISDTPMTWSNWHKHVNWLNTTFIIFVPLAGFISAYWVPLHLYTAIFSVIYYFNTGLGITAGYHRLWAHTSYRAGTPLKIYLAAVGAGAVEGSIRWWSRDHRAHHRYTDTEKDPYSVRKGLLYSHLGWMVFKQNPKRAGRTDITDLNEDPVVVWQHRNYLKCVIFMGLVFPTCFCGLMFNDWLGGFVYAGILRICFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWWQYDPTKWAIYAWKMLGLAYDLKQFRANEIEKGRVQQLQKKLDQKRATLDWGTPLEQLPVISWDDFVAESKNGKALVAIAGVIHDVTDFIKDHPGGKALISSAIGKDATSIFNGGVYTHSNAAHNLLSTMRVGVLRGGCEVEIWKRAQFENKDVTYMNDSAGQRIHRAGTQVTKVSQPVASADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT19</accession>
    <name>A0A7D5UT19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PKS-NRPS hybrid synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PKS-NRPS</name>
        <name evidence="3" type="ORF">G6M90_00g025060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985914.1">
        <property type="nucleotide sequence ID" value="XM_066129948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT19"/>
    <dbReference type="GeneID" id="26237518"/>
    <dbReference type="KEGG" id="mbrn:26237518"/>
    <dbReference type="OrthoDB" id="2422440at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482:SF5">
        <property type="entry name" value="FAR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482">
        <property type="entry name" value="OS11G0632001 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="556"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="274"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="631" mass="69702" checksum="853A7DAB93950365" modified="2021-02-10" version="1">MSSLGPSGSNAHGLNFSQAGLRRSAAFPPTHANQHQHQPNKQSPAPHAASPYQPQGYTPQQPPQGTYPPHLFASPVNPNIPNGHPPSRTPNSHVPPNALGVQRQRAAPPRQQMPPQPNPPPMMFPTNILPIRATLAIQATSSTHLIISSKGITNSIQATNLINSSSSNNNNSSSSSNNNISNINSTSSTSSTNNINNTNSIRHTRHTRHILRIRLIRLIQAIQAIRSTPQQQQQQQQQQPSQQPQQQQQPQPPQAQVTPQPTPQQSTPQPPQQQIPQQQMPQQQQQPPQQQQVQQVQQVNQVQASPQQPAAQVPQQQANHAGSEMDVDGNQDGDASEVNGLDSKLLNDPSYVPSQPMGEMMSPPPEGGSYPTLEAVQKAVLRYCTSVGYAIVIGRSKKTVPGLKKVLFVCDRAGKPPSRVSPEFRKRKTSSRKCDCPFGFFAIEQRTQWTIRYRPDPAHLQHNHGPSESPSNHPAARKLDSKMVAAVKQLKENGAGVSETLQILQTENPDCHLLPRDIYNARAAINRNPQKVATGLAENRPAIYTKPQQSPEDRIRADLRRELAKAREDLQKIEEEKQKEIDALKSQLEEKEKLIKRFEMFIDICNERVMVQRERLAGPDGNLAIGGNSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTG2</accession>
    <name>A0A7D5UTG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DPH1</name>
        <name evidence="16" type="ORF">G6M90_00g034870</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546882.1">
        <property type="nucleotide sequence ID" value="XM_014691396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTG2"/>
    <dbReference type="GeneID" id="26239445"/>
    <dbReference type="KEGG" id="mbrn:26239445"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI66476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="454" mass="49982" checksum="A433A1BAE1D4641B" modified="2021-02-10" version="1">MEDDRAQVDLGIAADIEEAQLTQAHQPEPTSDDAPQSTTKQPKKRFVGRRAAAEAAAKNGTTSADGESGAIQAAKPRRAPRLLNRVPKDILDDPNLKEAIALLPANYSFEIPKTIHRIRTSGAKKVALQMPEGLLLFATTISDILTQFCPGIETLIMGDVTYGACCIDDYTARALGCDLLVHYAHSCLIPVDVTKIKTLYVFVDISIDTAHLLASLERNFATGKTMAVVGTIQFNATIHGVRSNLEAAGFKVLVPQIAPLSKGEILGCTSPRLKDEDAVDMILYLGDGRFHLESIMIHNPSIPAYRYDPYSRKLTRETYGHDEMQSLRRSAIHTARTAKRWGLILGSLGRQGNPHTMALIEKRLKEKGIPWVNLLLSEIFPGKLAMMSDVECWVQVACPRLSIDWGYAFPRPLLTPYEALVALGVKEEWDKGSVYPMDYYGKEGLGRARPLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTG3</accession>
    <name>A0A7D5UTG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein bud22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bud22</name>
        <name evidence="4" type="ORF">G6M90_00g039700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547323.1">
        <property type="nucleotide sequence ID" value="XM_014691837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTG3"/>
    <dbReference type="GeneID" id="26239886"/>
    <dbReference type="KEGG" id="mbrn:26239886"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="17"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="444" mass="49103" checksum="CC611720ECD37F08" modified="2021-02-10" version="1">MPKRKRSGQSSVHAELEKYQDEVFRALKASKGFERQRLSKRLRDPGITQDKVHRLEREIAVLKSLDLHQTARAHLHLSLLKVKSIASSADLPQELLRGVSKPDLPEDEKAALHNVTSGLYNREPVKQVVGRAVEAVCGVLNVPVPENDRRTRKNKKEDGEEQPSARAEKLPDETKFATPSENPADEWDEESEFEGFSTDVDDPGSVLEEQELDSDAEVKEVTEFDKLDGLLGSSSDEEDDWSSDKYAQFRGRETVNLDDISVSGSGEESEAESVSQASSQSLSPPPEKKQKKDKKASAKTGPVRDSTFLPSLMGGYISGSESASDIEEAKPKNRRGQRARQAIWEQKYGSGAKHLQKPQKKSGRDSGWDMRRGAVDGEDRGRGTPWKKGIQNPVARNGMRGDGAPAPVAKRDDEGKLHPSWEARKKAKESQKAVAFAGSKVVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTU3</accession>
    <name>A0A7D5UTU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g043760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547710.2">
        <property type="nucleotide sequence ID" value="XM_014692224.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTU3"/>
    <dbReference type="GeneID" id="26240273"/>
    <dbReference type="KEGG" id="mbrn:26240273"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="65"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="193" mass="22033" checksum="320470EE421228A2" modified="2021-02-10" version="1">MICHQLSRRAVFITRPLQRTLQPLLLQRAKRYGAFDANLDQEALAEARTWYQSFDASQLPKGSTTYARSSGPGGQHVNKTETKATTVYSVRDLLSTLPRNLHAAVRSSKYYVASNDSLTFQDQTHRSRTANADENRNKLLEEVIRIYKETTPTETSGEKKKKYEAIEKRFHEARIKQKKFASAKKQSRKGPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTY2</accession>
    <name>A0A7D5UTY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neutrophil cytosol factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NCF2</name>
        <name evidence="10" type="ORF">G6M90_00g041960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547536.1">
        <property type="nucleotide sequence ID" value="XM_014692050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTY2"/>
    <dbReference type="GeneID" id="26240099"/>
    <dbReference type="KEGG" id="mbrn:26240099"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06408">
        <property type="entry name" value="PB1_NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034892">
        <property type="entry name" value="PB1_NoxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="426"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="242"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="515" mass="58464" checksum="C3DCAD688A5AABED" modified="2021-02-10" version="1">MSLKLEIETWVAALARYDNNEFDDALGEFDRIADTSKILFNMGVIHATLGEHEKAVECYQRAIRLDQYLAVAYFQQGVSNFLLGDFEEALANFNDTLLYLRGNTMIDYAQLGLLFKLYSCEVLFNRGLCYIYLQQREAGMQDLSYAVKEKVVEDHNVIDEAIREEAEGYTVFSIPVGVVYRPNEAKVRNLKTKDYLGKARLVAASDRSNAFTGFTGSEIKNAGQNEVKDDRPADNISFAATNLVKPGIQSRRQQSEPPTSRNVFPPTPPPENDRPNRGSVRNGSRPTPAKLTIQTQDIGRKYEKAPSPEEIRATRSASSSVSRGFSRRDLPPMQRRPTRPIEEEDEADPADLYDMYQGRGGGSSMSRDSRPSTRSRQQPRYPEEDDGSDYDGSLGGAEFEMVSNNRRRQGSRSDSRAASRRPEIRKIRVKVHADDVRYLMIGTAIEFQDLVDRIKDKFGLRRRFKIKIKDEDMPDGDMITIGDEDDLEMAIQSATNQAKRQRLEVAKMEIWIFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUD5</accession>
    <name>A0A7D5UUD5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g049420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545051.1">
        <property type="nucleotide sequence ID" value="XM_014689565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUD5"/>
    <dbReference type="GeneID" id="26242392"/>
    <dbReference type="KEGG" id="mbrn:26242392"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="423" mass="47780" checksum="0C736E83498639DE" modified="2021-02-10" version="1">MAAADSSRLQEAQKLAKTDPRKSEAIYKEITSKAPAATSDAATREYESALISLGELYRDEKKTQELVDLVRESRSVFSSFAKAKSSKLVRQLLDLFKEIPNSTDIEVHITKDCIEWATAERRAFQRQDLEVRLVALYMTKQSYYDALTLINSLLRELKRLDDKLRLVEVQLLESRVYHALGNIPKARAALTTARTSAASVYTPPLLQANLDMQSGMLHAEDKDFNTAFSYFIEALDGYDSLDESAKAQAALQYMLLCKIMLNLADDVNQLMSSKQAVKYAGKNLEAMKAIARAHSNRSLEEYERALSAYRYELGSDAFIRNHLRRLYDAMLEQNLIKVIEPFSRVEIDHIAKMVGLDTQQVERKLSQMILDKVIIGVLDQGAGCLIIYDETQRDESYDAALATIDKLSNVVDVLYTNQASMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUV9</accession>
    <name>A0A7D5UUV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein farnesyltransferase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cpp1</name>
        <name evidence="10" type="ORF">G6M90_00g038100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547169.1">
        <property type="nucleotide sequence ID" value="XM_014691683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUV9"/>
    <dbReference type="GeneID" id="26239732"/>
    <dbReference type="KEGG" id="mbrn:26239732"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="83"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="211" mass="22937" checksum="8A2B267D25A9AC1E" modified="2021-02-10" version="1">MAAPQPRSPVAADSESRESSLARDEGHVGLAPSIPGLFTSEPPIRDALATDSSQIQDETVEECMPFLTGYGHDNCNAHGIPPLLRDRHVKFLQKQLGLLPSMFKGADPSRPWIFYWCLAGLSLLGEDVAGYRSRLIETVRPMQNETGGFAGGFGQTSHLATTYAAVLSLALVGGDEAYELVDRRSMWKWLCSLKQPDGGFQMAVGGEEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVS9</accession>
    <name>A0A7D5UVS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein FMP25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FMP25</name>
        <name evidence="3" type="ORF">G6M90_00g043660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547700.1">
        <property type="nucleotide sequence ID" value="XM_014692214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVS9"/>
    <dbReference type="GeneID" id="26240263"/>
    <dbReference type="KEGG" id="mbrn:26240263"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="350"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="518"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="604" mass="65763" checksum="6F2F00DDE18E7537" modified="2021-02-10" version="1">MISSRVALRRAGHIRWSCQPRFTARRQWARYNSDSSKGPAHRQGGNPFARAAVYAGVFGLAAAGAYYYPELKESFSTEEEAIEPSKAQPRFEKSRRQPISKEDNRDIISSQHLQVKNSWEHPGVYAWGSNSGKVIDPESNDKYVKLPRRISFFNDQILRDLKLTHSFGAAVNEKGDLIQWGLGFSSSDPKPVTTLRGKDLAKIEVSTDRIIALSRKGDVYSVPSSRDDLEGGVKETRQKSSWSLWSSTGKEAINFRNLTPSGLGWGERVIDISSGLEHCIMLTSKGRVFTAASSAIAYPSKGQMGIAGLTWETRPKGPYDQPHELLSLKGFEATAIASGDYHSVILDKLGRIFSFGDNTFGQLGFTMDSGLPYATTPSMIPVDKLYAASGMVPKATSIKAGGTNTFFTVDASAPTTAVESRSMVPAKRMPGTISDLWVCGQGVAGTLGTGKWTHVSIAPTKIKALSSLFEFDEETNKNVPIKLKALSVGSTHCAAVMDNITKTNTSSSGSENETNWGADVLFWGGNEYYQLGTGKRTNMNTPTYIGPLDGGEGDANKRRKGEMHRLCLTPKQTVRIGEGGKGRKVTLEQKVECGRLVTGVYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVU0</accession>
    <name>A0A7D5UVU0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein SEY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">SEY1</name>
        <name evidence="12" type="ORF">G6M90_00g050660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545170.1">
        <property type="nucleotide sequence ID" value="XM_014689684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVU0"/>
    <dbReference type="GeneID" id="26242511"/>
    <dbReference type="KEGG" id="mbrn:26242511"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="760"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="784"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="47"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="855" mass="95089" checksum="37336900362D890F" modified="2021-02-10" version="1">MNGHFAAVGDKPAGGSFEHGVQVIDEDKEFNENLNDYLQTTNVADSGFNYHLISVFGSQSTGKSTLLNSLFGTEFSVMSETERRQTTKGIWMSKNKREESGGAKMADNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFLKDKQSTPRSLLFFVIRDHLGTTPLANLRTTLIQDLTKIWSTISKPQGLENARIEDYFDFGFAALPHKILQADKFTSEVDKLGSRFTAGHKGHKGSDHELEGGVFLAEYHRRIPADGFSVYAEGIWDQIVNNKDLDLPTQQELLAQFRCDEISREVLVAFDLIVAPLEEQQGEATKLGKILVLPDLGGVGSDARGALLRAFETQASRYHKGVYTRKRLELESKVDARLKALYMGQLAAAHKAGVGAFSDAVSNKVKAGQKAGGGYEFAEIVASEKKKTLDIFKSEAQGLAIEDLPWTNFKPQYQLFEAELDEVSGKLRKEEMRRLATRVERWVKSRLGEAIGLEFNKLGSGRAGMGAPETGDKPSEKDLWDRVWNVFAGIVKEAEGRFADRARSFDASDDEAEVGMWRLRRKSWVGLREKIEEEVMEGNILLKLRENFEDKFRYDEAGVPRIWRPTDDIEGIYTKARESTLTLIPLLSRFRLSTTYAPPDLVSFIGGQPAGVEVGDEEDLSPIGGVDEDEGKSLEEEMTVLSEGKRQDLVVRFKKTADGVYVEAKRSAIGGVAQIPWPFYALLLALGWNEIFMVLRNPFLFIFLIMLAGGTYVAYTLNLLGPMMQMSNAAVNQGVEIAKQQLRDFIANSEAARSALNVPSAPAYSERESISMDTLDGQGRKASPSEEVDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWE4</accession>
    <name>A0A7D5UWE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g047350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544854.1">
        <property type="nucleotide sequence ID" value="XM_014689368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWE4"/>
    <dbReference type="GeneID" id="26242195"/>
    <dbReference type="KEGG" id="mbrn:26242195"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="411" mass="45990" checksum="141C61C963576B4B" modified="2021-02-10" version="1">MSFVAKPVIISGAGVVGLTLAHGLKKANIPFEVYERDDHIDARGHGWAITIHWALPFLVELLDDATLEAVENVQVDPEVGRNDNGNFLFINLETLDSKFRIPPNKRRRVNREKLRKALLQGVTDHVRWGKRLDSIELANGEKGGVRAHFTDGSSVEGSMIVGAEGTNSETRKFLVPDNYRNHQLPVRFIGAAVDMTPEQAKPLRDIDPLLFQGCHPVTGHFLWVSMMESPEVNGTKGTYDERYRVQIITSWMVKSEKDEVPPSDAGLVAEMKRRAAGFHPLLRQAVEQIPESAPALEITIQDWPCFDWDNRDGRVTLVGDAAHAMTMYRGEAANHGMLDAYNLVQCLKKMYSGKVSRKAAVDEYEEEMRDRTGGEEGAVMLSRQACLDAHDFHGLNEKSAVLKKRAIKAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWM0</accession>
    <name>A0A7D5UWM0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g050480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986589.1">
        <property type="nucleotide sequence ID" value="XM_066130490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWM0"/>
    <dbReference type="GeneID" id="26242494"/>
    <dbReference type="KEGG" id="mbrn:26242494"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="425" mass="47775" checksum="9A4743E3448EF642" modified="2021-02-10" version="1">MAREPLHQLPREPWYTRGGGPVPRAPLIMWSLCRKLVASLALISCAVWYAQTHFYRDPGSRFFDPSRAYEQKYSRHRRAEVQQFIEQYASAGAAHDAPTRGESGAGRSLCVTFTSVRRQRIQYVETAVASALGNLLPQERADVYVNVFIAETNPDLAPGMGPLGRRQPAEHLETLEDKREFAEKGVFDYIYALEACAQTDTPYIGILEDDVLLADGWLARALLGLRDISNVRKPWLYMRMFNQERSTGWSSRWIGSHNEHWIVLAVWAGGSGPVVLARRRWRAARAHLDPAALLVLAGVAVPALVVLFFQCGKASVWPPSRGVVDEPFGCCSQVMVFPREQVASLVRFLGTRRGQVDLLLNEWAEEAGLARYALYPVMAQHMGVDSARGTVVDEAQAIWSMAFEDLEPARLDRDHRRMVKEYYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWQ5</accession>
    <name>A0A7D5UWQ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g057370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF3">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
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            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="16615" checksum="4A02EE602B94E789" modified="2021-02-10" version="1">MDARCQCGAVGFKTPLPEPLALYICHCAECKRQTSSAFGASAIFPRFRIPEAELLSCYARPTASGQTLYCYFCRKCGTRLLHTTPTKNVVSVKGGCLEGLDWAKAIHLWTKSAMVPIPEGSETHSEGSSSTDYGSTQEFLDQPLDQPGSELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWV8</accession>
    <name>A0A7D5UWV8_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g054240</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68930.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="18794" checksum="AE7755AA71BF53EE" modified="2021-02-10" version="1">MDYKPTIASPLPSSKRWVIPFSLRIAIIVCGVLVLALTGQPASTKNVIPILFLGPPAGLSILWSAADAACYFIHPSHHGITPGARVGMDLIISLAYISLEIVNGILIAGWTDEEYPSNTKDSDRIHAMVEAALAFGGIATIIHVGLFVVACVETHRENTEVKVLRVNALALGNMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5UWX7_9HYPO</name>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="QLI67692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20900" checksum="26D272F5D4B731BB" modified="2021-02-10" version="1">MILTQISESKLSTRYIPTSQFQDSQIEPCSGLDKDAYFKSGVPYILARTGSPSQHIPTPVVQQSLDRDVSAALRRNEAKPGTASFTAFVPEQDAALIVWNMAEVSKRRQTKCHANSKDITNAHELQALFTPREMVYTFRTFAASDPRDKIFAFYRVLNLSSEVRWQAITIRRWRRCTRGQRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWY8</accession>
    <name>A0A7D5UWY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541028.1">
        <property type="nucleotide sequence ID" value="XM_014685542.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246334"/>
    <dbReference type="KEGG" id="mbrn:26246334"/>
    <dbReference type="OrthoDB" id="5426191at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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        <location>
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            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
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        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="573" mass="61557" checksum="D14E188743A20B56" modified="2021-02-10" version="1">MAKAIEAKSLSDINDTANNPPQYFESAAGAKKQDPLVLYISRVVGLNVVILSPVIPNERVVSAEDVKSALYLVHVDNPVPAPVRGEAECRSSQDTRRLPQSIIPRRPVGGSDRPLTPESSPSASQSHQPSAIEAPGRTLYGLHTAMPPKKPVGSQSSPRTSTETSASAQIVSKDSSDPQEPSGNTQTHCINSISVPRPDTSLPPTNSANQSSLSNSQPISQAHSRSPSPRKHSTASTDMPLTLTLTRQNPAAQKWTVGYIRLPELESSSGDGDTASTSTTSPMQHHPIDIEIIQSGYAKFREHCVRKYSPTESGDLKAAAGSTARGSMDHQSSMYGNKEAFYRRVAMNYSNSLLTNAKEFARNLTRNRSDSAASVSSYKSDTAVKPDTICTFGSPPEGMKARGYTFVSPWEGQCHFSTGKHGNSLQCFYIPPATATVYSNSLVKTSHSESTLISTLSYNLALSPVQAKGPTGVLGKVIDCCSKSRKSNIPSDSRYESSFTSLGAERAGGGLNGREAKLATLTIYDDGLKMLDLLVAANIGVFWRTWEKFAPASTEQKHVSEAQIPFPSIEDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX63</accession>
    <name>A0A7D5UX63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-alpha-acetyltransferase 35, NatC auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">naa35</name>
        <name evidence="6" type="ORF">G6M90_00g049450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545054.1">
        <property type="nucleotide sequence ID" value="XM_014689568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX63"/>
    <dbReference type="GeneID" id="26242395"/>
    <dbReference type="KEGG" id="mbrn:26242395"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="54"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="336"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="768" mass="86630" checksum="B508C0E041BCD58D" modified="2021-02-10" version="1">MADHGIGAADELSQLSLGGHGPEPPMPPPNLRTAGIIATDISDNFAAAVRTLEPGELVKDGFFTLFDSVAALEIMDPKMDSGCVQPGEEFEVLYDVSRPLLPEEVLGIMDQLLCHEMSWHLGYPLSQTIFTSVYVDALLMPAPGSIRQAKFIRNGHQNVNQEPMLDILRAYCLGMLKACGHVNERIKSEHFYEEEDFVPNTYNRTLLTEFPTQDVKDVLKAARETVESLKGSIPDGVSEALTSRLDLRYIFLDATESPQYLKNLPKARLPWEEAIAILPRISSTHSLTKSVEDAFSTKLQRKLASTMPPRPIVQLKFDDAFNHLSRLLKDGLDVIGVLEYTNSQCLQNFVYTFQSKKPQPMVYVRTLLQTFLFNAMEILGSMSIRQLLDDDLSIITLPANTFLDRDNDEIEAVHDPRFVMSQQMELFRQKAAQPFLDIFRTACQNRCRVRRTLCHLIRDWENLQVDAEDIDQILQIKTKEPPLLQRSTLGLSPVETYSLPLSSWTYLYKLQQMEAIVQLGFELEVYQADELAGMYWYLNYLAKSRLQHTERIKTFVVRQATTVRSLHTIDPSQEAQLQRSLAYMRLSLLQAAVTWELSDALSCIYTVLNRYAIVKPPPRPYSNDQLRYDLRMRPFASIGLPSLPSFEEFTLGTKQPDTSTEELLEYAERAATGAKRGFETLSKYSAEDSFSVGSHEAWTTSVKGALKACIAAGVAISSLQKALRRTVGENGTGDVLHVTATVPTPDKAYHEWWIVPRIVPVVTMEMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXN9</accession>
    <name>A0A7D5UXN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GUA1</name>
        <name evidence="18" type="ORF">G6M90_00g053640</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986784.1">
        <property type="nucleotide sequence ID" value="XM_066130566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXN9"/>
    <dbReference type="GeneID" id="26246849"/>
    <dbReference type="KEGG" id="mbrn:26246849"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="211"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI69358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="542" mass="59796" checksum="79401264EFB64199" modified="2021-02-10" version="1">MASTLEAEAPHNSFDTILVLDFGSQTSHLILRRIRALGVFAELLPCTTKVAELPWKPKGIIFSGGPSSVYDEGSPHVDPAVFELDVPILGICYGCQEIAWRIDSSNVVRGEAREYGHADVTITKVNSHADRLFAGLGDGISVFMSHFDKLINLPKDFVVIAATKNSEFAGIAHEEKPIFGVQFHPELEHTPRGTDLLFNFSVNICGAQPNWKMGNFVEIEIARIRDLVGPKALVIGGVSGGVDSTVGATLMREAIGDRFIAIGINNGCMRLNEFEEVKKNLRDHLGINLTVVDAGELFLSRLAGVTDPEKKRKIIGSTFIDVFEKEAIRIEKEAENTPNSGKVEWFLQGTLYPDVIESLSWRGPSATIKTHHNTGGLPERMMNGQGLRLIEPLRLLFKDEVRAIGRQLGIHESLVNRHPFPGPGIAIRILGDVTKERVEIARKADNIFINMIKEAGLYDQMSQAFAGLDTSRSVGVFGDMRVWGYIVILRAVRTKDFMSAEVFNFDNSFLQEVSRAICNQVDGVSRVVYDLTSKPPGTIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY07</accession>
    <name>A0A7D5UY07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">20-hydroxy-prefusarin hydrolase FUS2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FUS2_1</name>
        <name evidence="4" type="ORF">G6M90_00g056250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. FUS2 hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544218.1">
        <property type="nucleotide sequence ID" value="XM_014688732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY07"/>
    <dbReference type="GeneID" id="26242630"/>
    <dbReference type="KEGG" id="mbrn:26242630"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028875092" evidence="2">
        <location>
            <begin position="19"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="201"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="439" mass="48465" checksum="096E1AB5842B4B76" modified="2021-02-10" version="1">MKLSQVSLLLTCATAVQAAPGFHSNLKRENSTSNAMMQLSADPDFHYELLRVISLAPYQGADVGEVLVAAQKIKPKDFESFYNVFNDLATRVDSTARAIDVRKNPISARQHFFKAATYYRSADFFLHGNWSDPRIYSLWDRHLAAFNSAIALLAVPGQRVNLRAKNDNFTIPAIFYGSGMPGPRPTVILGNGYDGAQEEMYHVIGQAALERGMNVLSYEGPGQPTVRREQNLGFIPDWERVVTPVIDYLLTRPEVDSRAIGLLGYSLGGYLAPRAAAFDHRLAAVFAVDGVYDYGAANLDMYPESLRAIFRSGNATLFNEYVEQGLADPAAKTAAIWGIQQGLWSFNAQTPFEWMTKVEDFNLASVVHNITAPVFVAQAEQDDVIPGQSKILAEKLGKLATHHVFESVDGAAYHCSVGASVLQNHVLLDWFEGVLEQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYT5</accession>
    <name>A0A7D5UYT5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g078470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545261.1">
        <property type="nucleotide sequence ID" value="XM_014689775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYT5"/>
    <dbReference type="GeneID" id="26241294"/>
    <dbReference type="KEGG" id="mbrn:26241294"/>
    <dbReference type="OrthoDB" id="4941129at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028871781" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20632" checksum="43248C4CC42CCF24" modified="2021-02-10" version="1">MASIKSSLLLASLASLSLATPLLEKQSKRAELLPYYLGKPHRFRNLQCAATGLGGRVLDEKICGTPYFCLYTAAAIDWELGHNQSYPTQEACLKDREPAPDGQQNAEGPQEGLIPWMERAVHDGHSCGRYGLRRPYNAVIYCGTEKYCEKVVEKGTATLDDCLAMFEKRPVGPEHPEDPKSDTQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYY9</accession>
    <name>A0A7D5UYY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">vps24</name>
        <name evidence="2" type="ORF">G6M90_00g072000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545861.1">
        <property type="nucleotide sequence ID" value="XM_014690375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYY9"/>
    <dbReference type="GeneID" id="26241894"/>
    <dbReference type="KEGG" id="mbrn:26241894"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="25825" checksum="37DAA032700B6437" modified="2021-02-10" version="1">METFRNLFAKPDPQAQFRKCNALIRSNIRKLDRDITANKQNEIKIKNLIIQADKRAQKDPARAKQAQKEVRDFAHELVRQRRASARTITSKAQLNSVQMQVNEAFAVRKIEGSIRSSVGIMKDLNRLIRLPEMAQTMQQLSTELMKAGIIEEMVEDILPEDGEMLMEDEGEVDKVLGEILKDRKEPSLPVAPVPEPQTQEVEEEEEEDAEAMMDQMRNRLDALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZD4</accession>
    <name>A0A7D5UZD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g071600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545899.1">
        <property type="nucleotide sequence ID" value="XM_014690413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZD4"/>
    <dbReference type="GeneID" id="26241932"/>
    <dbReference type="KEGG" id="mbrn:26241932"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028860193" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="274"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="513" mass="55893" checksum="032C27879F9A095A" modified="2021-02-10" version="1">MRIILLVVGYSALGWAVPTGAPIAEQTFVANVQQRAPSPTPASALDQRGLGDDIKSYVGSLASGVESKVSSLVESGILNFPNGFPAGTAVEKSLGVSSTELDVEPTQVLNLPSYGNWTENGWSLRIHGNVYKIPNVSQSKIDDLANVFLIGMSVKDLNATEQAQARNVTRSIFVVQQGNRNVTMNLRNNVAVQSNATGGAINAKGGAQTIHMPYNTTIEGDFDSFVDLRNTTGLNGGYMIPGNETSKIQTLNVYAEGTDSGNATAYLVPRTGLTVVSDIDDILRVTKIYQPKEGLLNTFARPFTPWMNMPSVYANWSSSINNMHFHYLTTTPEQATRNYMEFIYQTYPLGSFDTRPLNFSDASATLHIRRFLLDKIFQTFPKRRFVLVADTSNHDVMVAYPQMFKDYPGQVACIFLRNTSATDSGDKFPYDTSGFKGIPKDNYMFFKVPEDLAHLDVENGRCLNSTIPQNVTFGEQGLPLGLGDKGSLAGRIQIGAPTALFATLVTMTAAAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZK2</accession>
    <name>A0A7D5UZK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g072490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545814.1">
        <property type="nucleotide sequence ID" value="XM_014690328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZK2"/>
    <dbReference type="GeneID" id="26241847"/>
    <dbReference type="KEGG" id="mbrn:26241847"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="219"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="512"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="746" mass="82924" checksum="862B04FBC2918DE0" modified="2021-02-10" version="1">MPPGMVKSRVSLRSRIERDVYTVLKQLEAANGCRPFKTITTAYDAIQRSNSSLKRQKKRILEDAIDRVLLFRKQEADDSSDSEAAIEEAEPEKPEDERFLLNRQMTKLWHQDSPANKVESTEPSPAKKRRIQADTEDIPGQTSAVETVVNGNVSEGPSSVQKQDKQQMRKTQKASRFTVEHVDEEVPLGGLGEVYGDLLEHGCRLLRFANYYEENGWDRTTGILLSGPCGMGKRSLVKNVASMLGVPLVSLNGCLEDPERMEKSMTEAFDAAIAQAPSIVFIGEIDQYMSKTGSSNHNEHHSKAIRLFTQQMQRLKHRRGEDGYVLAMATTSKIADVDQAILKTGLFEVTKQLKIPDYEARQNILQTVTKKKTLAEDVDLGEIARITHGFVAAELVLITKLATELAAKCISEDAEATDVCMSEIKSAILSGNRDFFSTMRPRIRPRAPVSMEDFKSVIKDFTPSLRKEGFTVIPNVTWDQVGALDKARKQLHMSIIGPIKRPQVYKEFGLKQTAGILLWGPPGCGKTLVAQAIANEAKASFILINGPELLNKYVGESERAVRELFQRARSSTPCILFFDEIDSIVPPRANSSTDSGARVVNALLTELDGAQDRTGVYVIGTTNRPEMIDEAILRPGRLGVQLFIDLPTPSERVDILRAIYRTRHENPSPVAMEGLSSVAQDPRCANFSGADLSGLHAKAAESALERWMQDETSSKEMIEADWEFALANTRASVRDPASYRERDMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZS4</accession>
    <name>A0A7D5UZS4_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g077680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689850.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241369"/>
    <dbReference type="KEGG" id="mbrn:26241369"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="150" mass="15831" checksum="D44FBCA135CE166D" modified="2021-02-10" version="1">MSLHYLPPVKPSAIALGTFFNHGIELAVLGPVFGQTYQRAKQANTKEEFIKSKEASGAAIAWGTSFVGSALQSYGVGALINATGTLSYKGAAYLGGLIFAATAAPGFLTQIFSEKRPIDTVGVSIAAKLVETIGLSLFLTWWGTRTNPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZV3</accession>
    <name>A0A7D5UZV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g067300</name>
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    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987159.1">
        <property type="nucleotide sequence ID" value="XM_066130850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZV3"/>
    <dbReference type="GeneID" id="90967885"/>
    <dbReference type="KEGG" id="mbrn:90967885"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="39" mass="4385" checksum="54C9CCB362E69A04" modified="2021-02-10" version="1">MAYIAGLTCSLLPVYNWVGFKLSLKRILKGKKAAKEFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZZ9</accession>
    <name>A0A7D5UZZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MTLD</name>
        <name evidence="11" type="ORF">G6M90_00g070510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540627.1">
        <property type="nucleotide sequence ID" value="XM_014685141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZZ9"/>
    <dbReference type="GeneID" id="26246500"/>
    <dbReference type="KEGG" id="mbrn:26246500"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="213"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="398" mass="44283" checksum="41C06FD53E25A789" modified="2021-02-10" version="1">MAVGGLKKKAVHFGAGNIGRGFVACFLHNSGYEVVFADVVDSLIDKINSSPSYKVIEVGSEGTTENTITNYRAINSKTHEEDLINEIAIAEVVTCSVGPNILKFIAPVIAKGIDRRSNDDTPLHVIACENAIGATDTLAKHIKDPRNTAPERLEDHHLRARYANSAIDRIVPAQDPNAGLDVTLEKFFEWVVDKTPFQDVGIPSIEGINWVDNLAPFIERKLYTVNTGHATAAYHGYNRRKRTVYDALQDRAIMAEVRGALMETKNLIVSKHEFEEDDQAAYVEKIIKRIGNPHLEDAVERVGRAPLRKLSRKERFIGPAAELAEAGQPIKYLLDAIEMCFRFQNVEEDEESKELAKIMSESSPEEVVSKVCGIQTRDKIHPSLVAIVQRVQDDSRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0K8</accession>
    <name>A0A7D5V0K8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein 6, OR allele</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">het-6_7</name>
        <name evidence="2" type="ORF">G6M90_00g076330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545468.1">
        <property type="nucleotide sequence ID" value="XM_014689982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0K8"/>
    <dbReference type="GeneID" id="26241501"/>
    <dbReference type="KEGG" id="mbrn:26241501"/>
    <dbReference type="OrthoDB" id="4850726at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="639" mass="72660" checksum="CCC836BBD41B1E6A" modified="2021-02-10" version="1">MLDYQYIPLEESQLRVLTLLAGEFDDPLTGVLTHEQFLPANSDIPKYEAISYFWGDQIDMATIAISQGRHQRRKLIRPGLATALRHLRRQDQPRNLWCDSICINQDDLVERAAQVLLMGEVYREADRVIVWLGPEEDDSSAALEILDHIGSNVRFDPARYELSPLTGTNRKNRKLGDPNSALSYKQREWLAIKKLFARPWFTRLWVRQEIVLAKPSAIVVAGYAATTWSRFGQAVACIEVKIALGNTNSPFLTRFVNDVSNIVALFRTTLFRHPVALLNFTRSCQCRDDRDRVYSLLGLIDSSYKICPDYSRNVKDVCREFMLSIYREDARLDVLAFCDTTASPSWVPNIPGQNPAHHFWRNFATGYSEARLDMMQGDMMGVRAVKCGLVSNLIGHIPRGCAEDELKERVKTMLKQQLGTDTRKWKDDATVKLTQALLGGHWFENTSHQHDPQLMGVVSVLKNWVVEDLGGTNGKDAFLDMLVIWAMLNALPGWSVYRAKNSLFGICSSMCLPGDQIYAVLGCKDPIILRKRRDFTHYRIVGPTYIHDFSCGQAILGQPAFSSSFVDSFDDPYLSFERADGLGNKGDPHLQHIDFPYKVEDDHPLWHRNKGSVGRNQVDSSHLEAFYKRGVRVEEIILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V115</accession>
    <name>A0A7D5V115_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IPI1</name>
        <name evidence="6" type="ORF">G6M90_00g091900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541835.2">
        <property type="nucleotide sequence ID" value="XM_014686349.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V115"/>
    <dbReference type="GeneID" id="26245303"/>
    <dbReference type="KEGG" id="mbrn:26245303"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="5">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="37558" checksum="1C4DD229361F2486" modified="2021-02-10" version="1">MGSSAKKKKEKQKDFQKPKYKVGKTKPKASNFTDTSFKSKAIVVGQQSLSTDAPDYVQQFKHNLSLASSSRSDKQRRDSLAFLTSQLSVDQPSNPIGTIALLNKILPLVSDSSTPVRAQLLKLLQTLPRDEIKHSTEHASMYIRAGMTHLSADISNNSLAVMEWLLEVAGSELVNCPGGWVKTLGTFCAMMGWAVSSSNGGWTSATRTSMKAKDAQTLAKQITALSRFLQAGFADESSQVESSSQYWDALYRVPRAPNSFEYLNLSGARRDEEGEMYSNRAARQEIFCKRFLDAISKGLDKAKKEGGATGRAASSMEQVLKDGLADFEPSTAMDTQDLLDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1J0</accession>
    <name>A0A7D5V1J0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase [NADP(+)] GabD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gabD</name>
        <name evidence="5" type="ORF">G6M90_00g090270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541685.1">
        <property type="nucleotide sequence ID" value="XM_014686199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1J0"/>
    <dbReference type="GeneID" id="26245548"/>
    <dbReference type="KEGG" id="mbrn:26245548"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="498" mass="53530" checksum="EA123617C303A610" modified="2021-02-10" version="1">MTADLPFQLADTSLARPDCLVDGQDTSAKSGRRFQVIDPGTGKPWISCPDCGSEDVDAAVQSSHRAFQEYSKWTPRKRAQTISKWHQLIVEARQDLATILVHETGKPLAEAYGEVDYATGFTWWFVGEAERAHGSSIVSAVPGRRAITIKQPIGVAAALVPWNFPIALTLRKMAAALAAGCTMVVKPSPETPLTAIAVARLGLKAGFPVGALNILTTSLDNTPAVAESLCLHPLVKKVTFTGSTRVGKIITGLCARNLKKSTLELGGNCPFIVFDDANIDQALGQLMALKWRHAGQACISSNRLYVQRGVYDSFVKELIQRTSLLKVGHGMAEGTTMGPVTTPRALDKAEEMAKDAIANGAKMVYGTGLRAESTGGYFMSPTIVTEVTDDMLMSKDEIFAPLLGVSVFDTEDEVTTRANNTSMGLASYVFTKNVDRLWRMFETLEAGMIGLNTGNSSCAEAPFGGIKESGCGKESGKDVAVEEFLVTKNGTLTVEDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1N4</accession>
    <name>A0A7D5V1N4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g085870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541146.1">
        <property type="nucleotide sequence ID" value="XM_014685660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1N4"/>
    <dbReference type="GeneID" id="26246135"/>
    <dbReference type="KEGG" id="mbrn:26246135"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="29275" checksum="C75F2328714DADEF" modified="2021-02-10" version="1">MAQLPVQTLHRDPQLFYWILIPITVVMVLTGVLRHYASVLMATAPKKLDAKGMREQRALAHGVTLRSNYHVLSQKAFEQRRETLCAGYESGAYLKEPDRKGQPPANPLTDPGAMDGMMGMMKNNMAMIIPNTLIMSWINAFFSGYVIMKLPFPITIKFKSMLQAGVQTKDMDPRWMSSISWYFLCIFGLQFVYVFLLGSDNAASQMAQQMAAQQMPMNPMGGPGQDPDKQFKTEAENLAVIEHYSVLDDVEERLLQGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1R4</accession>
    <name>A0A7D5V1R4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g083440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543565.1">
        <property type="nucleotide sequence ID" value="XM_014688079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1R4"/>
    <dbReference type="GeneID" id="26243742"/>
    <dbReference type="KEGG" id="mbrn:26243742"/>
    <dbReference type="OrthoDB" id="3192019at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF11">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="182" mass="19991" checksum="EF1E1FA5F806B424" modified="2021-02-10" version="1">MRRIRYNAAISLDGFIASPDGSTNWIIEDASIDFDALHAEFDYHIMGRKTYEVVTSYGGANPLAAKPKENVLVVSRTMKQEEYPGITILRHDFIHTIRQLKAQQGRDMWLMGGGQLAAALFEARLIDVVEMAVMPAVVGEGIKMIAGSGGAAQSGYRLDLSAVERLHTSGIVILKYAVLYDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V222</accession>
    <name>A0A7D5V222_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative glutathione-dependent formaldehyde-activating enzyme</fullName>
            <ecNumber evidence="5">4.4.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">S-(hydroxymethyl)glutathione synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g069800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-(hydroxymethyl)glutathione = glutathione + formaldehyde</text>
            <dbReference type="Rhea" id="RHEA:22488"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="4.4.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540694.1">
        <property type="nucleotide sequence ID" value="XM_014685208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V222"/>
    <dbReference type="GeneID" id="26246567"/>
    <dbReference type="KEGG" id="mbrn:26246567"/>
    <dbReference type="OrthoDB" id="3446116at2759"/>
    <dbReference type="UniPathway" id="UPA00562">
        <property type="reaction ID" value="UER00621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051907">
        <property type="term" value="F:S-(hydroxymethyl)glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00723">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014185">
        <property type="entry name" value="Formald_GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02820">
        <property type="entry name" value="formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003829">
        <property type="entry name" value="PRK05417.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033318">
        <property type="entry name" value="Formald_GSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>structural</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="191" mass="20716" checksum="3A4125DEBF20D270" modified="2021-02-10" version="1">MTLSLHPLIDGGIVKGEANFAGGTLYCHCPSDKVAVSLKSNVAHNHACGCSKCWKPHGALFSIVGVVPRDSLSVIANGSKLVVVDKTAAIQRHACTDCGVHLYGRIEKDHPFKGLDFVHVELSDNKGWQEPQFAAFVSSIIEQGFDPRRMDDVRAKFKQLGLQTYDALSPPLMDLIAVFTAKKAGIHFSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3I6</accession>
    <name>A0A7D5V3I6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3 family protein artA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">artA</name>
        <name evidence="4" type="ORF">G6M90_00g097270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987751.1">
        <property type="nucleotide sequence ID" value="XM_066131526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3I6"/>
    <dbReference type="GeneID" id="26241037"/>
    <dbReference type="KEGG" id="mbrn:26241037"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="56"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="326" mass="35613" checksum="8B6ED589DEA5EC8D" modified="2021-02-10" version="1">MASFFHGHPQAGHTRDSTSGPARWRPSTSPVQSTVVAALGQASVGVLALPASGRIAAGKTFLARLCEQAERYDEMVTYMKEVAKLGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGSDKHVSTIKEYRSKIETELEKVCEDVLNVLDESLIPNAASGESKVFYHKMKGDYHRYLAEFASGEKRKGAATAAHEAYKNATDVAQTDLTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDNAEAEGAGAADAPKKEEGEAADKPTEEAKAEEPAPEATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3V7</accession>
    <name>A0A7D5V3V7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539777.2">
        <property type="nucleotide sequence ID" value="XM_014684291.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3V7"/>
    <dbReference type="GeneID" id="26247442"/>
    <dbReference type="KEGG" id="mbrn:26247442"/>
    <dbReference type="OrthoDB" id="5185064at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO/CreE_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052189">
        <property type="entry name" value="L-asp_N-monooxygenase_NS-form"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40254:SF1">
        <property type="entry name" value="BLR0577 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="660" mass="71626" checksum="1526178A0DEF1C8E" modified="2021-02-10" version="1">MKNSSAALGSPTVSVMPLDFGHVDSAHHAHVAIVGAGPRGTSSLERVCSSASEFLGPSGKLTVHVVDPSPPGPGMVWRREQSSQLLMNTVTSQVTLFTDDSVVCAGPIRPGPSLHDWAREAEPDLGPDDYATRSQYGGYLEWVFGEVVRRAPPNVAIEVHSALAVRLNDAIDGSQTLTLSTGETLPGLAAVILAQGHLPLHMDPELKRLADYAAENALRHFAPSNPADLDLSVIQPGEAVVLRGLGLNFFDHMALLTTGRGGRFTTSPQGKLVYHASGREPHMYAGSRRGIPYHARGDNAKGAFGRHMPLVLTEDVIAQFHRRANAGNAPDFFRDIWPLAAKEVEVVYYEALLRARQKGAAVPSHFRQRFLAAPHESRHEAQLLEEFGIAKADRWSWERIQRPQGSRAFATAGAWKTWLLEHLRQDAREAALGNVDGPLKAALDVMRDMRNELRLIVDHDGVQGSSYRDHLDRWYTPLNAFLSIGPPRQRIEQMVALMEAGVLDVLGPRMRVQAEGGAWLASSPEIPGWTARGTTLVEARLPEPDLRRTADELLGHLLKTGQCRPHVLDGYETGGLDVTPSPYRVVDAQGRAHPRRFAVGVPTEGVHWVTAAGARPGVNSVTLTDTDAVARAALHAARSEMDKGCEPAIQASSLPMAIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V471</accession>
    <name>A0A7D5V471_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor gsfR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsfR2_1</name>
        <name evidence="7" type="ORF">G6M90_00g098660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987783.1">
        <property type="nucleotide sequence ID" value="XM_066131548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V471"/>
    <dbReference type="GeneID" id="26240902"/>
    <dbReference type="KEGG" id="mbrn:26240902"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="573" mass="61796" checksum="1B9FC46E85967F87" modified="2021-02-10" version="1">MNGTKRSWDDMDDAAAAAAAAAAVTMDSFTAAFGNHGQDHSTVTITTDGTRLDDNASAASRQKSCNACVRGKRRCDKRTPQCSRCSAKGLDCIYQKLPPGASTAETCSSAGASAANLTTESAAESARPLGSVTSSCPVSAAATAGGTAGTVSASCAGLHTISSSSAASTASCVSDVPEFDMSFDMDSLGTDTSPESLQADIGVPLSNSTHGSGGLDFSIVDLMAQTTGGEPDFWNLHPFAEITTDKLQIPSVPTGHCNMTPPSMLHQNLQQLQPIRDLSLIKDAEAACMEIDPLAVHDPSTRIGYIVSFLTSMHSTFTQTRALPFMHPRLWVGQLPKVILAAFSASSAYTACGPANKGWTVRLLVDAGREIHREGERAISNEDKLSRVQALLILNSMRIFDGDLGLRAAAEREVPVLVSWLKELNSITENLEMEENLGGVNTVMREKSPKSWESWVFLESCRRTLITSYAIICISCMLKSETPNDDMWRDDIGFTASRHLWDAPNSVEFYRAWREKPQFSIQKMVFKDFWMYARPDDCDDFTKLMLTTQVGLDAMAHFMNGDAAIPVNPGRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4U1</accession>
    <name>A0A7D5V4U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g105960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539587.2">
        <property type="nucleotide sequence ID" value="XM_014684101.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4U1"/>
    <dbReference type="GeneID" id="26247584"/>
    <dbReference type="KEGG" id="mbrn:26247584"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="536" mass="57417" checksum="BD460D4A71269F46" modified="2021-02-10" version="1">MAIQRQIPMIIVLVLGFTVRSFGLATLLFLFTMGFVASIDVLTADVKGLQSLLGQGHVTSRSLVESYLAQIDRHDGYLHAMIQITPTHLLSERAGQMDRERRAGSIRGPLHGIPIIIKASVLGKSTTALGGSMMPSGWSAVGGQTQSAYVRGGLDPDDSKDGHSNPSGSSTGSAVAVSAGYAPVSIGAETDGSLICPAGRASLYTIKPGIGFVPQDGIVPISSHFDSAGPMAKTVYDLVVVLDAIRSNQGSKSLVHNITGSWEDISVGTLDPEVWKYPDTIMKPVTEATEQILRDINGAYDIIKGKAKRFAANVPLATPDSFELDGENSETVIIQTDLKTQLNSFLQDLNESKVRSLEDIIYFNKQHADQELPTHHPRQDLFIEAQERHVSVQDYNRHLKHLENAARGDGVDHILQQYEVDVIIGPADSFLTSMATGSGYPVAGMPLSYLDFNGRAFGLAAIAGQNQEALLVKDHVIVFKGSLVLAPFAEDMVHHDAEISVTGGFFISAVVEAVVEELDAGVVSANFGEVAVTFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4U5</accession>
    <name>A0A7D5V4U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g099530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546395.1">
        <property type="nucleotide sequence ID" value="XM_014690909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4U5"/>
    <dbReference type="GeneID" id="26240818"/>
    <dbReference type="KEGG" id="mbrn:26240818"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="386" mass="43364" checksum="7AF7CBEB6AE4DB36" modified="2021-02-10" version="1">MASAHHRHQNSLEGILDFSSSPPLREDERALAESRFRQIIEHYEAYERPPPNTRYNRIELIRSTYNFARSGESKDNVLRAFFSAVGLPMKEPGDVDFSAKEIEDDILAKLTGFADYLIDNFFLPLKASTRRTPQPSPAFHSATQSTQAGGQTFIGTMARLKTLRGDCLQRDRHRCVISRNFDQNEAVKRWNTSRADAVDDDGHALHDGVIEPLEVAHILPHSLVKANVDLELNDTREAALKILNMFDDGVTHLIEGPDIDRPRNALTLTHKLCLFFGDFQMYFEPVHGEPNTYRIDTFLPGSFLDNLLPVTRTLFLTESRGIEPPMPRLLAIHYAIAHILHLSAAGPYIDKILEDAAEQDVRADGSFPLGQLVQLKMEGLLGDIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6Q1</accession>
    <name>A0A7D5V6Q1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin-protein ligase RNF12-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnf12-a</name>
        <name evidence="8" type="ORF">G6M90_00g108340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544012.1">
        <property type="nucleotide sequence ID" value="XM_014688526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6Q1"/>
    <dbReference type="GeneID" id="26243399"/>
    <dbReference type="KEGG" id="mbrn:26243399"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="257" mass="27956" checksum="487ACEBD4660B442" modified="2021-02-10" version="1">MSQPSVPSDWPGTPPTDTPAPSTDASRTSGLASGLCIALAIIIGLAFYVLRGRIFPLGAYTAATPPRRSDTLTPEALALLPTHTHDAVLAETSSVRGAGPGPNDRCCSVCTEPFMHGVQLRRLPCGHQFDRACIDPWLLGRSATCPLCRRKVTTRPLKIHEKLPMSPRPTFFPPSRWRRDGDSSRAEWTFSVDETPRLTALQGPPGSSVVENARRDWHYGQSTRGQRRAPGFRPSGTLATVSESSTAETREMVENRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKL7</accession>
    <name>A0A7D5YKL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g020160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548528.1">
        <property type="nucleotide sequence ID" value="XM_014693042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKL7"/>
    <dbReference type="GeneID" id="26237972"/>
    <dbReference type="KEGG" id="mbrn:26237972"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="32813" checksum="85D53F049008A67F" modified="2021-02-10" version="1">MASLAVPSHQRPTSSTPTSYNLPSDSSDVDPDNDAPLPFPAALPRSDFLVPDFDPAAYLSALPHRHQTLEDLRSDLRDRSSTISSELVELVNSNYTAFLSLGSELKGGDEKVQDVKVALLGFRRTVEEVKVKVAKRRDETREFNDELRHVRLDIEQGRKMLEIDDRLSALEERLSVDSLPAGAGQKEWDWDSSDEEEDEGAVAGLLGSPPAKLLPSAKECGEIILLKEPLDQQHPFVLKLGERLNRCRNTLLLDLGNALKEAKGAGVQGHDRVLKYLAIYRMLDAQREAIRALRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNC3</accession>
    <name>A0A7D5YNC3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaredoxin-C6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GRXC6</name>
        <name evidence="9" type="ORF">G6M90_00g048170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
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            <taxon>Dikarya</taxon>
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            <taxon>Sordariomycetes</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
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        <reaction evidence="1">
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            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
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        </reaction>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
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        <source>
            <dbReference type="EMBL" id="QLI64162.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="516" mass="56606" checksum="70EF085DE55B7838" modified="2021-02-10" version="1">MTQELERIFADLGLSQYLNAFIDQGFDAWDTILDIQESDLDALGVKLGHRRKLQRRIANARGIAPSVSLSSSVKPGSDESKQDEVKRDSSRTVAESNGVTKRKYRRHPKPDENSPERPPSAYVLFSNRMRETLKDHNLTFTEIAKLVGENWQSLQPEEKDVFESQANAAKEKYNRELTEYKKTPEYRKYSQYLHDFKERQAKQYKGQDGSKRAKVEPARLRHGSTSSSATPNTTNSSASGSNSERLRGSEPPPTRRECVDSTTSLAESPHSSAAPTPMSAQNSYDDAGPSPRAMQFDNGSPTDAHQPSRHQPTMRGRGRADSMQQHLPSLSDMLDARQKAIVHPVADGLSYPSRPANSSTRTSLDSASLLSAGRTPTLRHESSSNGTNISGSSMGSFGRPPGEGPLPIHALLSDRTLVGSSVHEQQPNPILNGATGPMNTQQSLVGFAHGPSGYGFQSDSSPFHHMRVEQSSEGDVVMTTDETLAPQRQSRGTKDNLDGMNALLRAGEIVGRGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPB5</accession>
    <name>A0A7D5YPB5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539641.2">
        <property type="nucleotide sequence ID" value="XM_014684155.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPB5"/>
    <dbReference type="GeneID" id="26247552"/>
    <dbReference type="KEGG" id="mbrn:26247552"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="765" mass="86876" checksum="56FA6298F869607C" modified="2021-02-10" version="1">MSYCGDLTDYTGLSNEADQEKPIQRPNIASLAAQALEAFERCLHLSASYSRNGAFRVDYHLRDFEHWTHNAGVFSPGRACLDHAVRPADVLHDDICSDLKNLIQRIQDSSSILENTTNSRQENSTENDLNDAIKAIAKVIKSLYDPIESGQAKEISRRTWYSTEAKQFSLRDDNNNDEEPRLRKLYLDFIRGRFPNIKDYLPQRLAEYMLLQRKRTLFRRYYHRAHPLRVEHIVPRPKIVRPQFLRHAPEPSGEESEVESDVESDVESEAPLAKGITLSQAAKAAEAAAEMYEQDSASTPSALSITQMFALSKHEDLVFPPAPNAMVKQVFEELKKQRKKTLKECPTEIPGFADYEEYKRQPSRSHAGSASSFAEIDRRVTEEKKKFRACLQRDWICCNVKVGEVVCPFCLYVLPAFSVSDDEKWKAHITSDIEIYFCPFDKCKTPTEPYYDCDSWILHMGGCGWQNYYAQDVINQRECPICGANHEDDLECHIAGHLKFLALKALPLPPGYNGPQGLEAANNTEKHALPVFEDSIDGSACSDDGDDVTDGDSVERSLFDGVPKEDWGRCEWGFLTRANDNQFGSFPVTDYTQPFREVFIETTPKIIQTEKSLKILYEASGPNEITKDLDRTIPSWVMDHTKRRQLLNGPEVTRFEGHTRLFLASFYASGELGMQKVLWRSPTEGKNLSATYFSGINLSKAPVSGTGKGTGRLVPQGIRIDMLLEPRSPLPREARHNSSWQDWVRKWAPPNVESSRYLMSEDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPQ3</accession>
    <name>A0A7D5YPQ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein hsp88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hsp88</name>
        <name evidence="8" type="ORF">G6M90_00g007540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549756.1">
        <property type="nucleotide sequence ID" value="XM_014694270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPQ3"/>
    <dbReference type="GeneID" id="26239200"/>
    <dbReference type="KEGG" id="mbrn:26239200"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="722" mass="80189" checksum="E495A6FFF32D3DB3" modified="2021-02-10" version="1">MSVVGVDFGTLQTVVAVARNRGVDVITNEVSNRATPSMVGFGSKNRYIGEAAKTQEITNLKNTVSCLKRLAGRSFNDPDIKIEQQYITAPLVDINGQVGVEVSYLGKTEKFTATQLVATYLSKIKQIAASELKLPVSDLCMSVPPWFSDVQRRALLDAAEIAGLKLLRLINDNTAAALGWGITKLDLPAPEEKPRRVCFVDIGHSNFTCSVVEFKKGELAVKGAAWDRNFGGRDFDKALVDHLAKEFKGKYKVDIYTHGRAMARTIAAAEKTKKILSANQQAPVNIESLMNDIDVAAMITRQEFEAMVEPLLNRTQAPLEQALAQAKLTKDDIDVVEIVGGGSRVPALKERIQAFFGKPLSYTMNADEAVARGCAFSCAILSPVFRVRDFSVQDIISYPIEFAWEKAADIPDEDTSLTVFNKGNVLPSTKILTFYRKQPFDLEARYAKPEDLPGKQNPWIGRFSVKGVKAEGQDEFMICKLKARVNIHGILNVENGYYVEDQEVEEEIKEDEKEDSEKKDPDAMDTDKKEDAPKKTRKVKKQVRKGDLPISSGTSSLDAAQKTALSEKESAMVMEDKLVADTEEKKNELETFIYDLRAKLDEQYAEFASDDEKTSIKAKLEIAEEWLYDEGDDASKGVYIAKLDELRALAGPIVQRHFEKIEAERRAVQERNEAEQAAKRAVEEEARKAAEAEKAAQQGSNDQEMKDADASQVQSEEPTESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQF5</accession>
    <name>A0A7D5YQF5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GRC3</name>
        <name evidence="14" type="ORF">G6M90_00g043800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986531.1">
        <property type="nucleotide sequence ID" value="XM_066130335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQF5"/>
    <dbReference type="GeneID" id="26240278"/>
    <dbReference type="KEGG" id="mbrn:26240278"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001156">
        <property type="entry name" value="Polynucleotide 5-hydroxyl-kinase grc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="291"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="734" mass="80309" checksum="5582312F98F87E45" modified="2021-02-10" version="1">MSSSKRRKLDGQGPPQSPVSAVSAIAARRRQAASVAQSQATEPANLAEPSTPSINSFSALQTLRPDRNVTRPPKKSSKQSVQLRNDGRRLLAADDPKAAERLPNNQISEDVQSSFSATLSQTISYSSFSLTKSNCRTKAGGALELTLDEGERFLVLGSFGIRVVGGEVTLAGATLHAAENIHWVSAPHCVALPVIRTIQDTQLELHNDPNTSGLRKLGRLSPLFRRIWNEPSEAVDGIMAGGQTFQIIVSSSDAPRRCAIQELASPPEWNKKLASLLSISETGQRTTFVCGPKSAGKSTFSRLLTNRLLTSSNGENPVKRVAVLDLDPGQPEFSPPGTVSLVCVSNPNFGVPFTHTAFDDPSNTILRCHSLASVTPASAPDLLVSCATDLYGTYQRSLRTCPLIINTPGWILGTGLDLLVELITRIRPAEVIYMSEDGPADVVDVLKNATKNSFSMLPSQPSEFTSRTAAHFRSMQMMSYYHSHIDIENKRLRPPRVTWSGHAISSARPFVVSYHGSNSGVFGIISYDYQCTPELLAASINGSILAMVEIEGPEAFRQFTGTPEIRGDRDIAMTPEVVVTRTAEDLPFIPNPNDATLDPQYCRTIGLVLIRGLDLKRKCLQVITPTPYASLEKIKGEGRNIVFVHGRFDTPYWAYTEDLFAKSSQEELVDKEVHITDEETSEDESREEKAQPGGTDHAMISTIPWIEVLDGTQKRPVGSRVWRVRRDLGRHNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR27</accession>
    <name>A0A7D5YR27_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bud site selection protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BUD6</name>
        <name evidence="5" type="ORF">G6M90_00g008620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549647.2">
        <property type="nucleotide sequence ID" value="XM_014694161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR27"/>
    <dbReference type="GeneID" id="26239091"/>
    <dbReference type="KEGG" id="mbrn:26239091"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="432"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="377"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="881"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="658"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="932" mass="103193" checksum="224423EB8B149086" modified="2021-02-10" version="1">MPLSQIEKSVTHLLVATKQLLETLTQWSRGQATDTQVSDVYVRLGYEFNMACRAFTAINVDTSDLGNVPDLLRHILEATLSQEASTDSLEKYLPRIRDIIINLLHGLKRKQQRLRQRQGRERDASLPERTTSVSTAASGTSGLTNLLDEGLENGYRPDPSQRGDPNQQTNTSTPPGRRYNHQRDQARAENIPDQSTITQNIPSAPPYPAEDTTMPPSSSASDLNIDAFPPPPPPPPDTQSSALAALQKGGDLERRASRRYSQYQISKHLGGAANGMPILPSQTTPIPNRGRREARESLRAVQSRESVRHSRTLSSQSKSAAVEASPSRMPGVPEASSSAQQQPSGPAELSDGPAVQTPEEKYAPSATLNGPLQDLSSFMRESAPPEPDVKQTRLQSKTDEPASLPHPTESKPGESFFQVSPPLTPTKDLTLFLQYKSKVKKIVLAEGRDELSIGRLQLAFIEKFSWNTQHNGTDLPEIYIQDPVSGVRHELEDLSDIKDRTVLVLNVEPLDEVKRHFDDGMLALTKIVQSMKQNVDDQGTTLQRVSDRQQETATELARLATASPVPPAAEGGVRMLPGAGRRLNAGQAGELQSLRRDLAVLRQTYSSFQSDVQNSMTSIRQKAANVKSAASTATIPDIEGNAGYSYVTNGRKQLNSDSDRLVGKVDDLQDLIEDLRKDVVHRGVRPLPRQLEEVAKDITNLTKELKKMEEYMANEKPIWTKIWEKELEDVCQGRDELRLMEDLMVDLNDDLDKASETFTLVEQATKEQMKDNGTGASASTARQFSRGLSHLGNSLDQSAAKEDMLGEVRALQPNHENRLEAIERAEKLRQKELEGRRGNAMLREIATYVQDGKLKKSGGFEEVERSRKAKDERIRREVWERQNGIIPEDPIGEEELQSEEQAEQSADGEEFHDAAPTPVTEDAPKEAAETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSJ1</accession>
    <name>A0A7D5YSJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g066680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539274.2">
        <property type="nucleotide sequence ID" value="XM_014683788.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSJ1"/>
    <dbReference type="GeneID" id="26247932"/>
    <dbReference type="KEGG" id="mbrn:26247932"/>
    <dbReference type="OrthoDB" id="5098281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="117" mass="13514" checksum="CB97BDA2B1E814D0" modified="2021-02-10" version="1">MSRQPTFTSIIHLRDFVDAITDDPTRENAPNYVEIQTDLNIFEEDGFHDPNIATDPIRTRIHTYLTQEQRELYVPGAFFYADGRFFTALSMNGTLEISTQTLSLMRQVWPNIRPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSL5</accession>
    <name>A0A7D5YSL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">STE24</name>
        <name evidence="19" type="ORF">G6M90_00g019910</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548552.1">
        <property type="nucleotide sequence ID" value="XM_014693066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSL5"/>
    <dbReference type="GeneID" id="26237996"/>
    <dbReference type="KEGG" id="mbrn:26237996"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="18">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="17">
        <location>
            <begin position="227"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI64744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="456" mass="52295" checksum="E400D8A56F0D8F34" modified="2021-02-10" version="1">MDFLQRLARYLDRPLFPWKKLILGFSVGQYLFESFLTLRQYRILQQTKPPAVLSKEISQETFDKSQAYGRAKAQFEIISGLWAQIQNVAFIQLDVLPKLWSWTGDLLLKWAPSRFTGEISHSILFVLTFIVIQQFLSLPTRVYSTFVLEEKFGFNKQTPKLFITDMIKTNLLTVALVPPILAAFLKIIQKTGNQFVFYLWVFSAGLQLFTTTAYPIFIQPLFNKLSPLEEGELKTKVEGLALSHKFPLQELFVIDGSKRSAHSNAYFYGLPWKKHIVIYDTLIEKTKTDEIIAILAHELGHWKLGHTTRLFGIAQAHLLYVFSLFSVFINNVSLYNAFGFHTTHPIIIGFILFSDALSPMDTVIKLLLNILSRKFEFEADDFAKGLGFRSQLASSLIKLHAQNLSTMDADWMYASYHFSHPHLSERLKALDWKSKDSLTSEKDREGVATATGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTS8</accession>
    <name>A0A7D5YTS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g088490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542265.1">
        <property type="nucleotide sequence ID" value="XM_014686779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTS8"/>
    <dbReference type="GeneID" id="26244779"/>
    <dbReference type="KEGG" id="mbrn:26244779"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028830517" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="219"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="556"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="731"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="870" mass="94992" checksum="8074C82BFF5130FB" modified="2021-02-10" version="1">MVRAALFARGLAAAILLTFKTANAINEPHTPRGANITNSVPLSVDPRSTLDVCEARTINYITHALPQSCLTISWRSPAPTSTASAGSQHGRDDGSDHGTDNQPSWPPTPTLDHNATEVQATEPAATTFMSFEDWKEMMLRRAGQDPQDLRSRRPSEHNTDDRYSPESGHAGLGEEGEISLNFEDYGNGDHQKLTSPRSTRGDGVDEQPAAADALLYEEGKAATVHLSKDAGKTCKERFSYSSFDAGATILKTSPGAKNARAILVENKDTYMLLECDAASKYVIVELSDDISVDTVVLANFEFFSSMVRHFRVSVSDRYPVKMDKWRELGTFEARNSRDIQPFLVQNPQIWAKYVRIEFLTHFGNEYYCPVSLLRIHGSRMLDSWKDSEGGRDEEALIDGDESAGADSHQDENHVADAAASRDTNIHIMASNGTSSRSLSYALEIFTNMDATCPAPSSAGANPPTRDPKLSSVSLGTSQESDLVSSDVSQARSASPENSGNSSIAQAKSILATGSINYSTIMPTSQDDRLRNHTGALNGAALNVNTTTIDRENNAATPTAKLSASSGQNGKPRSSGTTGASAASPTMQEGFFNAITKRLQHVESNLTLSMKYVEDQSKHIQEALQSREQRQHAKINYFLDELNKTVLAELHTVREQYDQIWQSTVLALESQRDRSERDMMALSSRLNLLADEVVFQKRMAIIQAIILLSCLFLIIFSRGVSLPSLAPLLDQPSNSPCATPTSPATPRQSSYQLSKRHHREGQSSFQPPDPSCQVQMLYPGEARSDTSAEALPFEAVSFQGTDEPKSECSAFQRLSPPPTPNLLGEMSLSSDPNSATGSNHTLRRRLGGTSHISSRKPLPSLPEHPRSLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTY8</accession>
    <name>A0A7D5YTY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxygen-dependent choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">betA_0</name>
        <name evidence="4" type="ORF">G6M90_00g017860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548746.1">
        <property type="nucleotide sequence ID" value="XM_014693260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTY8"/>
    <dbReference type="GeneID" id="26238190"/>
    <dbReference type="KEGG" id="mbrn:26238190"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF219">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="107"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="268" mass="29442" checksum="B8E30D2937F54CF2" modified="2021-02-10" version="1">MFSQSGKQHQPLPESRQQLQSSTLQRTKHAFLYAVAGKGWLRSAVDRAILLCTSHFDEEKGAVLATDAADDGETLPDVEIMVVPVGSLPELYPGKSMFTLQTCLIQPESTGTIEITSPDPGVDARIQLNILSDPSDWQVARKACRFALALAEHFIYQSGYPSEARVFAGPGSVGAREWKEGDWRVVSDQEIDTYIGMYVGCGFHLTSSCPMGREEDEGVVDSQLRVHGFKNLRIADASVLPCVPPGHLMAPTYMISERCADFIKHGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVY2</accession>
    <name>A0A7D5YVY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exosome complex component RRP46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RRP46</name>
        <name evidence="8" type="ORF">G6M90_00g098060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546537.1">
        <property type="nucleotide sequence ID" value="XM_014691051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVY2"/>
    <dbReference type="GeneID" id="26240960"/>
    <dbReference type="KEGG" id="mbrn:26240960"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="10"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="145"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="254" mass="27050" checksum="EDD4028CC8A12872" modified="2021-02-10" version="1">MTASSEPLAQLSNLPNADGSATFSNCGYAVTAAVNGPIEAPRRDENPFEALIDVVVRPAAGVGGTAERQIESMLQAALRQLIPIRNFPRCTIQVTLQIMEAPENAYQNTKLLQPQQNLAIIPALFHAAILGLLTAAIPLKTIATATTLAIPAGSGALIIDPSTEESAKATSLHALAFTSHDELLLAESSGSFSIEDWDRVLETGQRVCCRDHESGLDAAMPGDGLESQSIKAFIRSVMETKTGTDLNWKRSLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY53</accession>
    <name>A0A7D5YY53_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DPH4</name>
        <name evidence="14" type="ORF">G6M90_00g012460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549276.1">
        <property type="nucleotide sequence ID" value="XM_014693790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY53"/>
    <dbReference type="GeneID" id="26238720"/>
    <dbReference type="KEGG" id="mbrn:26238720"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF46">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="13">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="182" mass="20534" checksum="3CFB358EA61199C8" modified="2021-02-10" version="1">MSPPQPPTHYEILNLTPSIIDESPDAAKLIKKAYHRALLRNHPDKTISHANTPPGALFSIDQITTAFTVLSSPRQRTEYDTKLRQAQTFSGAAGPDSAQRFQTGVENVDLDDLPYDEAKERWYRSCRCGNLRGYLFEEEDLIEVEDEGELMVGCQDCSLWLRVHFAVVDDVIPVDEDPIDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYB1</accession>
    <name>A0A7D5YYB1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g041460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547491.1">
        <property type="nucleotide sequence ID" value="XM_014692005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYB1"/>
    <dbReference type="GeneID" id="26240054"/>
    <dbReference type="KEGG" id="mbrn:26240054"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="705" mass="81388" checksum="4D92C593BEB14448" modified="2021-02-10" version="1">MALRRPLWTKASWNRPPAVSPSRTESPATCAHGKLLSQAHPRQRQRQRHLASHAPTPAAAAPLRHHFADFLPPRGRTELDLVLDAVQTRDPELLYKAFLQWTDLLSNPSSPFNDGAVRQAQELPGPSFSEILRSIDPLLATRKHDVTHGLNLTQGQTQFTDVGKLVDQFGVRNHHRQVLRGMQILMEVRAGSRYGLAPADFDVLLRCAGAAVDYQAAKRFWAMMPSQGLQDVRTCKTWTEFIKSRFVVEPAYYQWDRSRVAVMARDMYSNRSPLPMATLKRLDSVRHCINAFKRRPWNRRPDELDEDMRRLVRRRIDFRGYKNHWIRGLFYGHEMDEELLCASLVAFARSSSLHSIKTLIFKNYYGIMIHQDAESNPENPQISGGVDLPPRSPIKPTGNLLNAIVEAFGSMSHVPLGMKLLDFVSRRYDVPIPRETWSNLLNWTYLCASKPFKPTRKLLEHSQYAVISGADVREVWNVMTSPPYNVSPSFDDYDIYIKTLLSQRSFVRVLAIVRNDILPFYEAVVDDYELAVQDEILQNDLGPSPEATHRRHQAEVYKDYVRHRISSWFDKLLKTASANKGHRDGVVMKTMIPNLLAEFADFFPHQVRYRTAQGAVQITRPDAVRRFQWVRCWRSTLPQKKAGFHVRDLDGSDEPDFAYPEAPVLNVRGWHRRPRRRIAQLGRAPRQEDAESRTWWHRLEEELIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYQ5</accession>
    <name>A0A7D5YYQ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546039.1">
        <property type="nucleotide sequence ID" value="XM_014690553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYQ5"/>
    <dbReference type="GeneID" id="26240462"/>
    <dbReference type="KEGG" id="mbrn:26240462"/>
    <dbReference type="OrthoDB" id="5405654at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42053:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="226" mass="24167" checksum="072947B86E1C3AA6" modified="2021-02-10" version="1">MPTTKPKLEKLSTPVTATFPSEITSATTATPLSALNFMSKPEPDFIKTPISPPSAYTDFLSKAMALNSPSLTPGDSSPDSTKSNPETERANRSSKTERSSPTSTVSSKPSPPTTAPVVPPSPFPTSAPMSAPPTGPASFPSLKLPPSPAISNIDSPLSASTLRSPFSARSVHSVFDWDAALKARRPEKKQNSSRTSVRHIREVVTRTVTYTPRMDPAPRGKRRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYS8</accession>
    <name>A0A7D5YYS8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g022160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548338.1">
        <property type="nucleotide sequence ID" value="XM_014692852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYS8"/>
    <dbReference type="GeneID" id="26237782"/>
    <dbReference type="KEGG" id="mbrn:26237782"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="247" mass="27334" checksum="C10F23E73BED6C40" modified="2021-02-10" version="1">MLKCSPVVRAFVRPRRQITHFSRLQRASYQFSRCYTKSAADDGSPGFKLHYPNPPTTNHSDLDSFIAYARRKGLDANSTVYVGTHYEYKVSSALAKYGFFLKRIGGSSDYGTDLVGTWTLPWSSPSAPFRVLVQCKAGTQRVGPQHIRELEGAFVGAPVGWRGTGVLGLLASERAATKGVRDSLGRSKWPMVYMCCSKEGIVSQMIWNQCAEELGLDGYGVSVRRGDDKDELVLMRNGAVIPLLQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ07</accession>
    <name>A0A7D5YZ07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-L-isoaspartate(D-aspartate) O-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g053550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540478.1">
        <property type="nucleotide sequence ID" value="XM_014684992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ07"/>
    <dbReference type="GeneID" id="26246840"/>
    <dbReference type="KEGG" id="mbrn:26246840"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="239" mass="26293" checksum="76B59FAAECA2AEA1" modified="2021-02-10" version="1">MAWRCSGGSNEQLIENLWRSGLITDPRAKEAFLKVDRAHYAPHSPYEDSPQYIGHEATISAPHMHAMAIENLLHYLTPSAASPAPRVLDIGSGSGYLTHLLAELVGEKGLVVGLEHIPALRQIGEENMRKSTEGMKLLDSGKVKFRVGDGRLGLKEPVRRGEEAHGTDWDVIHVGASARELHQALLDQLKAPGCMFIPIDDDASGVMQSVWRISKDKEGKVHKKNICGVRYVKLTDPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ45</accession>
    <name>A0A7D5YZ45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Common component for nitrate reductase and xanthine dehydrogenase protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">cnxH</name>
        <name evidence="5" type="ORF">G6M90_00g061070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542761.1">
        <property type="nucleotide sequence ID" value="XM_014687275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ45"/>
    <dbReference type="GeneID" id="26244710"/>
    <dbReference type="KEGG" id="mbrn:26244710"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="155"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="180" mass="19980" checksum="5DE58E7A2BB01D19" modified="2021-02-10" version="1">MASQDEDVWELSSEGCYVALTRDHLNVQTIMDRVRSPAAGAIVLFAGMLTQHLHHKNSRPDLDSGTTRDSFAGKPVKELTYTAYNKLALRTMLAITKDLINKHGLKGIAMIHRLGTVPIGEESILIAVSSPHRQAAWRAGEEALEECKSKVEVWKREEFDGEEGVWRANRDGAIGEKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ77</accession>
    <name>A0A7D5YZ77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Alpha/beta-glucosidase agdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">G6M90_00g112190</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987878.1">
        <property type="nucleotide sequence ID" value="XM_066131853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ77"/>
    <dbReference type="GeneID" id="90968269"/>
    <dbReference type="KEGG" id="mbrn:90968269"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028993196" description="Alpha/beta-glucosidase agdC" evidence="16">
        <location>
            <begin position="18"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="18">
        <location>
            <begin position="101"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="17">
        <location>
            <begin position="268"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="19">
        <location>
            <begin position="711"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI74362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="924" mass="101374" checksum="9D53734E13FE7F00" modified="2021-02-10" version="1">MKLWTSVLFSGLASAGALVNRDGDKALAKCPGYKASNVKTSGSGLTAHLTLAGKACDAYGDDLKQLVLQVTYETDDRLHVKIQDKDNQVYQVPESVFPRPGGSSSASANRLRFDYTASPFSFQVSRRDTREVLFDTSAAPLVFESQYVRLRTKLPRDPYLYGLGEHSDAFRLNTTSYIRTLWNQDSYGIPAGANLYGAHPIYLEHRDAGSHGVFLLNSNGMDVVIDKARDGSQYLEYNALGGVLDFWFFAGKTPTAVVQQYTEIAGRPAMPPYWGLGFHQCRYGYQDVFDVAEVVYNYSRANIPLETMWTDIDYMDRRRVFSLDPERFPLHKMRALVSHLHARDQHYVVMVDPAVAYQDYAPLTAGLEQDVFLKRANGSAWLGVVWPGVSVFPDWFARNAGAYWDAMFARFFHRDTGVDIDALWIDMNEPSNFPCNFPCDDPYAAAEGYPPPAPPVRAPPRPLPGWPCELQPANATDCYRSAAAPPPSPEPPAIAPAPRAAAAAAAGDQKGLPGRDLLYPRYAIHNKAAYKDAWNGAQGGLSNHTVNTDVRHQNGLAMYDTHNLYGSMMSTASHAAMLARRPGLRPLVITRSTFPGAGARVGHWLGDNLSTWAMYRASVRTMLAFTSLYGFNAVGSDVCGFGGNTTEELCARWAALGAFSTFYRNHNALGQAPQEFYRWPSVAASARRALAIRYRLLDYLYTAMRRASATGEPALLPMLHAYPRDRAARALEDQYLYGPALLVAPVLEPGATSVQVYLPAGALFYDWYSHRAVRGAGRALAVTAVDTASIPLFLRGGAVVPARLGAALTTTDLRRRPFELLVALDAAGRARGELYLDDGVSLDQRARHSLVTFAFDAASARLEVGGVFDYPGPPARVSKVTLLGSEGRDPAPAQTHALGGSRVYSRSFDVDWTLDRAATYTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ78</accession>
    <name>A0A7D5YZ78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g098140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546529.1">
        <property type="nucleotide sequence ID" value="XM_014691043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ78"/>
    <dbReference type="GeneID" id="26240952"/>
    <dbReference type="KEGG" id="mbrn:26240952"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="580"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="807" mass="90659" checksum="DE19B8293E1BE2D1" modified="2021-02-10" version="1">MSSQLPKLAPRPFGELPLGAGKVNPKEHTEREWEAQRGVIEHLYIGENRRLVDTMTIMTSKYGFAATEQMYKKRLKKWNLRKRAYRTTSENAVASTAASASDNAGSSKSGAEVLRQTPDRMLQQPACTTIARTTKLGPYAGLELVLDSVRSWSLCKLESRGVALDPMVRYLANPNQPPIQDSRTMYRTFELVFDLWHHGKGQLAGMAARRAFYSLEFVLTADHPDLVWHILDTVYDMVDRGHIQLLGMFLTHARELSTRRLPQEHPLVKILQELTKCDYQTRLGRERVCHLLRSAWLQNVDILSDHIGSPAPTHLWLYEQLIWDGRTSLRRDCELAKRGETMVAALAGLHQLADVDPRVSKLDRLRIMALMLEYTQMDLGDRQKAEELAVNLLNQTSLNNEASRSDARFHAYARKMLARLQEHEQDWVRAEENLRYAVEKREAAHGTGSDLRVIRDMWVLAGYYQRTGRGGAASQIVDDAISRAEQIRHDDVGDLQAHANSEPRSPISHNTLIKLNLIYLATIRNESLKSHTSRQQCLEDRRQITVTSITTDATHTAPSNSHPRCDSRSHRKGYDARNTQRLQAARLPKPPHDPNRFAKSNDTPTNNLLLSAALKTHPDRVAADSPERDARTRKFQLVNDAYYTLSDATRRRDYDAQRRLFGPSAPEADPFEEADEEIPQQPGAAAQGAYSWAWNFFNSRAAGAADNAGRERTEDAQFSDVFEEMMREEGMAEDGSNAPTSKFWSLVGGLSGGALGFIIANFPGMLAGAVAGNRLGAVRDAKGKSVYEVYSVSLLLPLTAFQGLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZI0</accession>
    <name>A0A7D5YZI0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543211.1">
        <property type="nucleotide sequence ID" value="XM_014687725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZI0"/>
    <dbReference type="GeneID" id="26244012"/>
    <dbReference type="KEGG" id="mbrn:26244012"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="375" mass="40424" checksum="970B98E472712F3E" modified="2021-02-10" version="1">MAPDKMKQWTTGLDGIDKLQMEEADVPRPGEGEVLVKIHAVSLNYRDKEVCSGEYDHHASSEPARRLVPCSDMCGTVVESRSGLLGEGARVASIFLQTHLRGAVREEDMASGLGLPLPGVLAQYRVFAAASLVRVPGYLTDEEASCLPVAGVTAWTSLNWMRPLGRHIGTDSKDDDGEHPDPGSRFVLLQGTGGVAVAGLQTAHAAGYRTIVTSSSDDKLRRAADELGADHTVNYKTYWEWQAPVMEATGGRGADVIFETGGARTLRKSFESVAFGGVINCIGYLSGKEDEDRPGGDGLQRLNVNVLALRRNVTLRGIINGGKDRFEEMLGFYEDKKIRPVVGRVFAFADAKEAMAYLASGKHFGKVVIKVGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZL7</accession>
    <name>A0A7D5YZL7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-aminocyclopropane-1-carboxylate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">aco</name>
        <name evidence="5" type="ORF">G6M90_00g010020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549514.1">
        <property type="nucleotide sequence ID" value="XM_014694028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZL7"/>
    <dbReference type="GeneID" id="26238958"/>
    <dbReference type="KEGG" id="mbrn:26238958"/>
    <dbReference type="OrthoDB" id="627829at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="221"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="377" mass="42009" checksum="9C3C765D121EEE0E" modified="2021-02-10" version="1">MEKSQTMVNEPKTVQLRLASGQEPVTRTILQTPPRDALPSEIPVIDISRAFSPSIDDRRAVAREIGDAAENIGFFYISNHGVPDAVIAGAYETALAFFRQDLETKLRAKIAPSQGKISGYRPFASQRINPDEGADHRETFSWAYDATYDPEMGDINAVPEHARKYIKADESPWEATSQMPELKAALVAYFQSCLGLARALTRSFALSLDLPEDHLDSKVKYPDVMMLLNYYPKKEPQPPAGARRQVSMGSHTDFRLFTILWQDSTGGLQILNRDGQWINGLPVPGTFVVNIGDFLQRITNDRYVSTVHRARSPSGEERVSIPFFWGFGLHERCGVLESCVGEGEGPKYDEISTQEYVASRSRQLMTWGNEADGGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZX1</accession>
    <name>A0A7D5YZX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">nit-6</name>
        <name evidence="23" type="ORF">G6M90_00g038730</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547229.1">
        <property type="nucleotide sequence ID" value="XM_014691743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZX1"/>
    <dbReference type="GeneID" id="26239792"/>
    <dbReference type="KEGG" id="mbrn:26239792"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011565">
        <property type="entry name" value="PRK14989.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="900"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1070"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QLI67083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120426" checksum="AA54FA7A9A21D139" modified="2021-02-10" version="1">MTTDKKRVVVVGLGMVGIAFIEKLLKYDAHERQYTVTVLGEESHVAYNRVGLTSFFEHRKVENLYMNPLQWYDEASVSLGYHINTKVTYINSASKTVTCENGDILPYDILVLATGSHASLPRHTPGCDAKGVFVYRTIDDLINLIDFAAERKESTGCVVGGGLLGLEAAKAMMDLESFSSVKLIERNGWVLSRQLDQEAGGMVVQQVGDLGLDVMLSRRVREIKVDGANHVVGVVFEDGEDLDCSTVCFAIGITPRDELARASGLDCVPRCGGIAVGDDLRTSQPDIYAIGECASWQSQTFGLIAPGVEMAEVLAFNLTQAKLHAPRVFKRPDLSTKLKLLGVNVASFGDFFADRDGPAHLPAKYKKLVNGAAKQAQTVKTLTYKDPFQNIYKKYIFTSDGKYLLGGMMIGDTNDYIKVVPMVKTMKELDVPPSQFILGAKKDGDGDDGDDLPDDTQICSCHNVTKADVVNCVKDGSCKDLGAVKSCTKAGTGCGGCMPLVTTIFNKTMAAMGNEVKNHLCPHFSYSRAELYHIISVKQLKSLREVMREAGNDDTSSGCEMCKPAVASILASLWNQHVMAKTTHGLQDTNDRYLGNIQRNGTYSVVPRVPGGEITPDKLLAIGEVAKQYNLYTKITGGQRIDMFGAKKQDLVDIWSKLVAAGMESGHAYAKSLRTVKSCVGTTWCRFGIGDSVGMAVRLEERYKSIRAPHKIKGGVSGCVRECAEAQNKDFGLIATEKGFNIFVAGNGGAKPKHSELLAKDVPPADVVPILDRYLMFYIRTADKLQRTARWLESLPGGIKYLREVILDDKLGICASLEAQMKGLVASYFDEWAEAIRNPEMVARFKQFQNTPDTVDSMETEQDRGQSRPVYWPKEPAAQDFGSMGGRWSSTAWEPVIEAVYFDGADELPNGISATVKRGDTQLAVWRFRGRYYATQQMCPHKRAFVLSDGLVGHNPAKSCSNDNDNDNGGGQQSAAPWISCPHHKRNFDMRDGSCSNDGSLSIATFSVEPREDGLLYLKLPPVEELDAALGTTKWRVRKGESGDSPFAELDRKMQLVGRKSRRVNGIKPTVNGTLDGSADGTGSESARPALMAGGGGCGSAPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0A2</accession>
    <name>A0A7D5Z0A2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NUC1</name>
        <name evidence="21" type="ORF">G6M90_00g018480</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548692.1">
        <property type="nucleotide sequence ID" value="XM_014693206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0A2"/>
    <dbReference type="GeneID" id="26238136"/>
    <dbReference type="KEGG" id="mbrn:26238136"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="96"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="97"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI63548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="355" mass="38510" checksum="E49626B7B4C073B0" modified="2021-02-10" version="1">MSKSTLAMFAALGAGGGAALTAAAFALRTSPENKKPELPIATPPTARPNGAASTTTALAIPSQHVYSTPPAVLGAPVNPAGLFEYGFPGPVSDIASRAALISSYDRRTRNPHWVVEHITPESLCSRDGDRKHSVFLEDTAVPVQFRALLKDYFRSGYDRGHQVPAADAKWSQKAMNDTFYLTNISPQVGDGFNRDYWAHFEDFCRRLTGRYPSVRIVTGPLYLPRRDPVDGKWYVRYEMIGAPPSVAVPTHFYKVIFAEDGRAGGNVAIGAFVLPNAAIPNEKPITDFEVPIEAVERASGLEFANKLPVTRRKRLCAETTCALVIRDYADRQKAFGKGGQRAISPPPSPPPSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0C7</accession>
    <name>A0A7D5Z0C7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">erg10</name>
        <name evidence="14" type="ORF">G6M90_00g028820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541285.1">
        <property type="nucleotide sequence ID" value="XM_014685799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0C7"/>
    <dbReference type="GeneID" id="26245920"/>
    <dbReference type="KEGG" id="mbrn:26245920"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="273"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI63429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="396" mass="40957" checksum="504D91C775245F2D" modified="2021-02-10" version="1">MSGLPPVYIVSAARTPVGSFLGSLSSLSATQLGSTAIKGAVERAGIKPEQVEEVFFGNVLSAGLGQAPARQCAIGAGLPNSTISTTVNKVCASGLKAIILGAQNIMLGTSDIVVAGGTESMSNTPHYLPNLRTGAKYGDQTLIDGVLKDGLTDAYKKEHMGLQGELCASDNDFSREAQDDYAIKSYQKAQAATEAGLFKEIVPVEVSGGRGKPPIKVERDDEVKNLNVEKLKAMRPAFKSDGSITAPNAAPINDGAAAVVLMSEAKVKELGVKPIAKILGWGDAEREPERFTVAPSLAIPKAIKHAGLTDKDIDFYEINEAFSVVALANIKLLGLDADKVNVFGGSVAIGHPLGCSGARIITTLTSVLKEKGAKIGCAGICNGGGGASALVIENLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z112</accession>
    <name>A0A7D5Z112_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine amidinotransferase, mitochondrial</fullName>
            <ecNumber evidence="3">2.1.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-arginine:glycine amidinotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transamidinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GATM</name>
        <name evidence="9" type="ORF">G6M90_00g001780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidinotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542900.1">
        <property type="nucleotide sequence ID" value="XM_014687414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z112"/>
    <dbReference type="GeneID" id="26244273"/>
    <dbReference type="KEGG" id="mbrn:26244273"/>
    <dbReference type="OrthoDB" id="10264242at2759"/>
    <dbReference type="UniPathway" id="UPA00104">
        <property type="reaction ID" value="UER00579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015068">
        <property type="term" value="F:glycine amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006601">
        <property type="term" value="P:creatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd21113">
        <property type="entry name" value="amidinotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488:SF1">
        <property type="entry name" value="GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="8">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR633195-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="351" mass="38871" checksum="E2F20440F0F97A76" modified="2021-02-10" version="1">MSTLISADNEWSPLKAVIVGRAEHSAFPSEPRAVFEASMPAEHVDEFRPGNPFPADIVAKAQEELDNLAAVLQQHGVKVYRPDEVDWLKVGGYTGSMPRDTLMTVGNTLIESPFAWACRRREVELGYSSILRELSSGGGGAARICRAPTIIGKDTIYDQAVVDGTRAPNGSPSWTINNTRPAADVADFMRLGKTLVGQLSHVTNMKGVEYLRAQVPDGYSVEVLRTTDDHAMHIDTTILPLRRGLAVYNPERVSEAELRRHAVFAGWDLRPCPIKPKPRAPPSPPMYMCSPWLVLNALSLNERQIFVEEHDVEFADWLRDEFGMEPIMLPFQHVNCLGGSFHCATVDLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1M1</accession>
    <name>A0A7D5Z1M1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PGS1</name>
        <name evidence="12" type="ORF">G6M90_00g065420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540232.2">
        <property type="nucleotide sequence ID" value="XM_014684746.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1M1"/>
    <dbReference type="GeneID" id="26247041"/>
    <dbReference type="KEGG" id="mbrn:26247041"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="52369" checksum="59A2244EA5D29E38" modified="2021-02-10" version="1">MAPSFDLRGEDIRVIRTPAEFYETLKDRIRNAKRRIFLSTLYIGKSEKELIETLRDALSRNPELKLDILTDGLRGTREAPDSSCASLLAPLVTEFGAERVEIRMYHTPNLTGLRKKYIPKRINEGWGLQHMKLYGVDDEIIMSGANLSTDYFTNRQDRYHLFSSGEVTEHFWRIHSGVASFSFLVEPSREDAGFTLTWPRTNSAPCPLEDPQSFIKSSSQTLKALVAPQAEKLPKGDFSNTRVYMLGQFSQVMKPDESTELPVITHILKQLALPQYRGSSWTFTAGYFNPAPSLTRLLIGTASTNNTVITAAPEANGFYKSKGVSGLLPDAYVLLARRFLDNISQSRRDQDIVLKEWRLGTAGHVGGWTYHAKGLWVTMPGETSPSMSIIGSSNYTKRSYSHDLEVGALIVTRDESLKRQLGDEQSWLQEHSKRVTRDDFAKNERRVGLQVRIAMWIVSLVGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1M9</accession>
    <name>A0A7D5Z1M9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g030010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539715.1">
        <property type="nucleotide sequence ID" value="XM_014684229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1M9"/>
    <dbReference type="GeneID" id="26247472"/>
    <dbReference type="KEGG" id="mbrn:26247472"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09999">
        <property type="entry name" value="Arginase-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32065" checksum="63D09556B336835A" modified="2021-02-10" version="1">MPYTSITIIVAPYHVGIYDHRVGGGPLRILAHGIDRELEKLAPVSFINIGPVDEFEGEIGRTFEIIRRISKAVSQAAENDSFPLVLSGNCYASTAVVAGLNKFVPSLAALWLDAHDDLDTPSTHENGYLDAMAASMLTGTSWHALMKTVPGHAPMDVKNIVYCGLRDVSDTQRRTIQSAGVDVVWGDAGRKVNFESELSAVLKRRNLGKTHIHLDLDVLDESLGRVNEFPSPGGFMPEDLMGLMKIIPTETDPTSLVICSFNPRLEGGDGVAKLAVRAACRLVGSLKEKGLFASNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1P3</accession>
    <name>A0A7D5Z1P3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PPM2</name>
        <name evidence="17" type="ORF">G6M90_00g007950</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549713.1">
        <property type="nucleotide sequence ID" value="XM_014694227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1P3"/>
    <dbReference type="GeneID" id="26239157"/>
    <dbReference type="KEGG" id="mbrn:26239157"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000043">
        <property type="entry name" value="tRNA wybutosine-synthesizing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="16">
        <location>
            <begin position="822"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI64229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115213" checksum="089F9486BF3B0093" modified="2021-02-10" version="1">MAAAAKAPMSYGPPKSHVLDELVMGTNSSSIVSKRSVEKLYFPEEPHYFRYFVKKFQRRAPLINRGYWLRLRAIDVVVRQFLFENRTTKKIVINLGCGSDVLPWQSHARHALLCDDVLFVDIDYPDLMLKKRSIVLETPQLREILGENFVVSQPDEDQILLQSDRYCQIGCDLRDISRLRHSLETLSPLADCHVLFVAEVSITYMDTKFADALIHWSSSVGKAEFCLLEQLLPHGPDHPFAATMLSHFDKLKTPPKSVSKYPTLAKQVSRFTGLGYTNINIWDLWEAWSSAKFVSSSERSALDNIEPFDEWEEFVLFGRHYFILHASATHQQEKIPFSPKYNHKEPCEKESIFPVSMVKHDVQTSKRRFGDVLAITDPTGAAYAVHIMGLGTAGREESHDIYSLDGKMDMPIVPITGPPPRMCHSITDLGDYGMLLVGGRTSPANTLSDCWVLHKGPLCKWVPTSSLPIPLFRHAAIRLRGSSLALIVGGKTGPSTISEDCYVFHATKGWSKCAILGEAPGPLFGAVLCNSPARLASDGIFTGLLAGGIGQDGLISSKKYRWKLDNNDSQPTIRFTKHEEEFEQLDDLAVFGAKTVNLESQTLVCGGVGACSRSQGQSILMVYMPDNDAYAVSKMGTCPEGKALPFMVGSAIMEAKDSIVILGGGATCFSMGTFWETGVFQLSFKGKEDDGVGSCGFTRHEPLKVRFLASQRIVSSTRQTLRQEANLEKATVATIPRVRLETPAQFEDILRTGLPVIISNANFGGCVQKWTPSYMIDRIGYNTKVVAHECKHDHERMDFNSKNFRYVTEPFGKVMERAEAGERIYLRALSRDKPSERPANIQDDFSALAEDFCLPRELDSANRCLFSSVLRVSGRINMWLHYDVMANVYAQVAGSKRMVLFPPRDVEHLQFAPGASSSSLNVFSELQTSRMAATHPYEAVLAPGDMLFLPPCWPHAAATITDWGIAVNVFFRDLESGYAIGRDVYGNRDLAAYEKGRLEVARVGKSFQHLPLETRRFYLKRLAEELESTAEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1S8</accession>
    <name>A0A7D5Z1S8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g061610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542710.1">
        <property type="nucleotide sequence ID" value="XM_014687224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1S8"/>
    <dbReference type="GeneID" id="26244659"/>
    <dbReference type="KEGG" id="mbrn:26244659"/>
    <dbReference type="OrthoDB" id="4129906at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46832">
        <property type="entry name" value="5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46832:SF1">
        <property type="entry name" value="5'-METHYLTHIOADENOSINE_S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="512" mass="56898" checksum="7863139845AA3562" modified="2021-02-10" version="1">MPTDKESRSNLRRLRSRPVCIICGRPAEAQQIARALGIDDEKHRLSGHDVSMVRDGHTFHLGEFKLPSGDILKYYITSSLRQGIQSFAVSAAILFNTLSPRFVLHAGVCAGFDDPTGKLGLALRDVVFGEAAINYEEGKWEAQGPGGNAVFLPDYKPVAVEAGDMQGFTKSHKRHGIRYGEYISGSSVRGDAAQVFEKIRSSVGRNAIALDMEASAFIQLCKHFEPKGPICLGVVKGISDFGDSKKGEDTSADSDALNNTAVAIKDWLTHRIPNTRWEVDESDEPGAKLVSGYYENFVRRVIDNYLEGLPIAYRHRPEVAIPASEIKGFISVLPKDQDPQFVKEIGQIQRTILEYGVEEINIGTNAAQRYVHYKGGFFLDWCRTVNSLVDEEDAEYQVGVFGRTLRKQAYYKQAEAKGPLAQVLPWEEAMHLLTDLKNDTRSIPRPDVELVGKRYEETLPRAKTPRGSAMTKTERKSSVSQLFAFGRFRRHHKPSGKEQEAAVSPLPVVGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Z8</accession>
    <name>A0A7D5Z1Z8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PBN1</name>
        <name evidence="12" type="ORF">G6M90_00g087460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987305.1">
        <property type="nucleotide sequence ID" value="XM_066131308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Z8"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mannosyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
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        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="497" mass="54304" checksum="470DBDCBF4F1F759" modified="2021-02-10" version="1">MKERVTFVHAQGVDVDPGLLKVDANQLDGPSVKAARENRLTVEVAELPPELAGLLQAYRDISIRWASPLTYGTVEPFTSRLSPGLHVFSTPANETAGHAQLRLCTSLQAFGSIDCMSAESFTTHGQGQSFNPPAATFHQELEHLSAFIDWVTKEICSKEDSVCRNRAEALSDAASLDILWDSTLRTLRISSLFPLTEQSIKVAGSSTRRTEVGVFSKDTPPNQKPHEIGVSGFLTVLGENKKPSGTLFGFPSRHRVADAYFSSDFVSPTGLHPTLRLTLSSNIPPPTEDECGLHAYFTLPRTIFADRYQFADQLFLASKNLTASRYTSLPVDLEAPAYTTKTWGSSVLLQLAPPSSNEPESWTAEVPLHLRYLEPSVSGKVDIEIPYPAVFWACESEAHVDLSNNPFDRTRLGYDGLFSENTVFWHATPQPATGGRILTPISVPVLKEDGAWLVGFGTAAAVALGFAWVLWKLAAVFAVSGYGSLSSETQMESKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z229</accession>
    <name>A0A7D5Z229_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter MCH2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g029670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541204.1">
        <property type="nucleotide sequence ID" value="XM_014685718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z229"/>
    <dbReference type="GeneID" id="26245839"/>
    <dbReference type="KEGG" id="mbrn:26245839"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52340" checksum="5756312A0D0E288C" modified="2021-02-10" version="1">MWESKQAADNSDSDHNPPSPNAHQSTSLYLAGQAKRPDARMSPDQPPNGGYGWICTLCVALINAHTWGINSSYGVFLAHYLSTDAYQGATYLQYAFVGGLSISCAMLVSPLATLSTRHFGTHATLSFGTALEVIGLIGASFAYNIWHLFLSQGLAFGIGMGFLFVGSVGIPPQWFTTKRSLANGISASGSGFGGLVYSLAAGAMIRSIGIAWCFRVLGLLAFTVNAICIALIRDRNKIIGSRHAPFDMKLFKRPEYLLLNGYGFFSMLGYIALVFSLADYGKKVGLTASQASVLSAILNLGQGLGRPPIGYFSDTIGRINMAGLTTFLCALLCFVVWIFAKSYGVLIFYALVGGTVTGTFWATVGPVAVEVVGLQDLPSALNLEWLIIVLPCTFSEPVALEIVEHSGNYLGAQLMVGFMYLAGALCVMLLRGWKVGELNEIARTKDQNPENHHHMDMSVGSTNELARAAGRRTILRHFWEWRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2J3</accession>
    <name>A0A7D5Z2J3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Satratoxin biosynthesis SC1 cluster protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987425.1">
        <property type="nucleotide sequence ID" value="XM_066131175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2J3"/>
    <dbReference type="GeneID" id="26243545"/>
    <dbReference type="KEGG" id="mbrn:26243545"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46458" checksum="86842268E1D61D1B" modified="2021-02-10" version="1">MSAQVLPSEPALAGGQMEMPPPEVKKFLGGIPTPTLDVPVTIVFLVLFSLGAYLHISVYKANAKRGHKFLLSSLMFDFCMVRVTTCLFRILWAFIGLQAPGIVLVANVFQNGGAVVVFAVNLFFAQRLIRAMHPSIGWHPVFSRYSLFLIWTCPAVTIMNIIAVCVNFLVPARAQGAETVLQVGACWNMMLVVTPLLWLFIASAKPGPTPENFGTGDFRAKASLLVFSASVMTVGAAVRLTIAFNHNGPEQLFSKASLYTTQFILEYLVVAAYAFFRIDQIYHIPNGSSGPGDYSWNGCPKRGLWTPEDIEREIGKLGVRYDILTSRGMNKKGPVFALLYPACSEQPFAHDNKDLPQVPPEYVDGFLPPRPRRVSRMDILTGSYSPERPPRSKRTTMFMTKDVELTPTITSSPYQKFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2K2</accession>
    <name>A0A7D5Z2K2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quercetin 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">QDOI_0</name>
        <name evidence="2" type="ORF">G6M90_00g063080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542574.1">
        <property type="nucleotide sequence ID" value="XM_014687088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2K2"/>
    <dbReference type="GeneID" id="26244523"/>
    <dbReference type="KEGG" id="mbrn:26244523"/>
    <dbReference type="OrthoDB" id="5370773at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20281">
        <property type="entry name" value="cupin_QDO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028816529" evidence="1">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="383" mass="42573" checksum="2A8B9A58E9AED4CB" modified="2021-02-10" version="1">MGFTRFLIFALAAATAESTCSSTGKNQSIIVHEAPQTIRPYVMPKYKGRAVLLSKTEVVRFAITANSSDGAFSMIQHNGKLTGYASARFHTHRHVHEHVYCARGRVELWAQKNTTDSIQEARVATLGDYGNLPIGSIHTFQLIDPDTQLTHIFHPAGFEHLFDFYSVGDFESLGVGTPYVPHIEDEAPFGPLTPELKTELASLDLYESEQFVPRRDLINGTAGDSKLNWHNGPNDLPTTYGEPYFIAKDHGKKFLHTETGYKIIQPLTNEATEKNFTIGTVIMSQKLANESATTTTLPHHFALQMEDGQLILKVEGYESTAMLHGDVAFIPAGTKFSYHAAVPFTKFLYMNDGYEGLDHQLLENAMPWELPAYPPYAGFKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Y0</accession>
    <name>A0A7D5Z2Y0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986870.1">
        <property type="nucleotide sequence ID" value="XM_066130586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Y0"/>
    <dbReference type="GeneID" id="26246248"/>
    <dbReference type="KEGG" id="mbrn:26246248"/>
    <dbReference type="OrthoDB" id="4941169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="54432" checksum="7EE20F8CE7561037" modified="2021-02-10" version="1">MADAQPQNGELAISKAPKNIYSRTNRCLSLFSKYRNMSVDQNPYQLYMAIYEVWFLFWVNTSSCLDRRLKFYPDMKELVMSMLSVLQRALRLASISHPLARTVVETDGALYGITGAISRLERLDQCIRNYESPAAREAREIRRLVATKWGDGSAALVWRLIHGRFPRAEPTLITQLVLSILHRRYRIIYHLLKYEKAMENANPGARRSQQREMADDTLLYPASYPDPPEVARGESKANCRYCFRDIVIPQSASRKQRRAQWESHLKADLKPYACLSEYCRHIPKLFSTADEWKDHMEMHNRYLIGNETNWFREIHRTKWPCPFCNDSNTCFITLHDLQNHLIEDEVTNHPDITGWDTSMLRRSRVPNPRDKYCCPLCNMEQKGRTPKKRSDRLYTHFIDHLEELALVSIYGWNVEISKITGQSISSTHSVDVGERNSLRRRSGPNHDQRKSMKRKILDCAKRFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z377</accession>
    <name>A0A7D5Z377_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator sdnM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sdnM_0</name>
        <name evidence="5" type="ORF">G6M90_00g052080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539402.1">
        <property type="nucleotide sequence ID" value="XM_014683916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z377"/>
    <dbReference type="GeneID" id="26247802"/>
    <dbReference type="KEGG" id="mbrn:26247802"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="492" mass="55954" checksum="C9A0B1AE9D1DE8C1" modified="2021-02-10" version="1">MLHLTGRRLPRPQIPTDTIVMVGDLDDNIVYRNEGIVTCMFVVDNVLDSEKLRSAFERVIERPGWRKLGARLRFNTNGCLEYHIPALFGPDRPAMRYSVVDHAVKRSEHSVASRLPEMSKDLAVVADPVHFESLWHDAAGPAKLDDYFYADEPLLALRITKFTDATTLAISWPHVLFDIMGLVDFVNAWTLMLRQQPDDIQAPHETTSDPLAELGRHPSEPHLLRHHRMSLLSVLFHWLQSWFWSLISKPQHRILYIPGWYMKSLREKALEGLATNNEDEDKNMFVSEGDTLCAWWAHLSTSLMRNYPGKIVALVNVMSLRTVLAEDLLPCGRPFLSNSTGLVFALTSVKDIVTKPLGHLASQVRRSIINLGTREQVEAFVALTRQSWQRLPPLFGNHRMHLVTFSNWSKAKLFEVDFSSAIVPPVSDKGQPTEQSGRPSYVQSHFSGINTYECVVILGESAEGGYWMDCCTNKFRWPKIVDMLSEVRQEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3V0</accession>
    <name>A0A7D5Z3V0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FBP1</name>
        <name evidence="16" type="ORF">G6M90_00g036840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547073.1">
        <property type="nucleotide sequence ID" value="XM_014691587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3V0"/>
    <dbReference type="GeneID" id="26239636"/>
    <dbReference type="KEGG" id="mbrn:26239636"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="16"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="208"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI68507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="339" mass="37432" checksum="972790CBC416C7F4" modified="2021-02-10" version="1">MADNSNGEKVNTNIVTLTRFLNEEQTKHKEASGDFTLLCHALQFSFKSIAYYIRRATLVNLTGLAGSSNTTGDEQKKLDVISNDLFIEAMRSSNKCALLVSEEEEDIIYFENATGSRYAVACDPIDGSSNLDAGVSVGTIFAIHKLPEGSTARKEDILKPGTELIAAGFTMYGASSQLVLTMKNSSVNGFTLDNGIGEFILTHPNMRIPKSRAIYSVNEGNSLYWEENTISYFNSLKQAQSNGKPYSSRYIGSMVADAYRTLLYGGIFAYPADKKSPKGKLRILYECAPMAMVFENAGGQALDSNMKRMMEVDPEHIHDRSGIFMGSYDEIEKVKSFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z428</accession>
    <name>A0A7D5Z428_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g043240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547659.1">
        <property type="nucleotide sequence ID" value="XM_014692173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z428"/>
    <dbReference type="GeneID" id="26240222"/>
    <dbReference type="KEGG" id="mbrn:26240222"/>
    <dbReference type="OrthoDB" id="5596992at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife RNA repair protein HAD" evidence="2">
        <location>
            <begin position="53"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="582" mass="63975" checksum="AF2DFDC0678B5C62" modified="2021-02-10" version="1">MASAYSVYHGASNGSPYTITAMGRWSCLNKTLPPADKIKALHVYDFDNTLFKTPLPNPALWAGQTIGLLATQEAFTNGGWWHDNRILAATGEGLEKEEPRAWDGWWNEKIVQLVELTIKQPDALCVLLTGRSEKGFSELVKRMVAAKGLDFDIVCLKPQVSPTNQRFQNTMHFKQLFLNALMETYKGATEIRVYEDRPKHTNGFREFFSEYNRRQNASPTRGPIDAEVIQVADTSTTLDPVMEVAEVQHMIKLHNNSIMRQPMHLRPNRLQIKKTVFFTSYMINSEDSKKLMKLVQLPSGLAGNELKIHANNILICPRPCPSSILDKVGGMGSKMLWEVTGTACYDNSIWAACVRPVPSTAAYHTDNPVPLVVLALRKGARPVDAGRIEHWQPLAAGQSFVFETTVGEKVILRVEDEDPRKDEYESLFANRHSKRKHVGDDGRVANSTHGQYGGRNESRGFHSGSRGGGRGRANPSRGFRGGARGAGRGGGRGRGAGYHYRSLDDVEPKNQQPGYGQPVGYDDAHPHLNQPQSQAPPTGPKASLGRGGSYQGRGGGRGGGRGGGRPMGGGQAANNTDLQNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5A3</accession>
    <name>A0A7D5Z5A3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dehydrogenase azaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">azaJ</name>
        <name evidence="5" type="ORF">G6M90_00g094750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987644.1">
        <property type="nucleotide sequence ID" value="XM_066131485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5A3"/>
    <dbReference type="GeneID" id="90968148"/>
    <dbReference type="KEGG" id="mbrn:90968148"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF2">
        <property type="entry name" value="ZINC-BINDING DEHYDROGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="21"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="406" mass="43286" checksum="6AE8226E1C58E930" modified="2021-02-10" version="1">MGNSQVPDETPPSQTVLLLRAPRQRYDLVDEYPVPRLAHESEVLVRNRAIGLNPIDWKAPDFGFGLPPLPCIAGRELAGEVAQVSPGNTRWKVGDRVAVISTDYRDPRKAAYQQFVVAREHTVVRLPARMSYEQGSAFGVAFAAAALALGVSLGADFSAVLDGPDLYRAVRGLGEDQLPRDVAVECLDGLEPDERPAAGDWLAVWGGSATSAHLAIQLARLAGLRVAVVVDCAKHGRWLSGHAVIRPDLLVDSHDPARAVDVLRAATGGRLRLGIDTRGRESATHLLQALRQTPCDAGEGGATSLMSPPGTPRRAKRRRGHLVGLAGLPKGAEGDDVVLHSVPIKLFHEVESIGGALVAWAAALLDKSLLLPPDIVDVEYGLDSVNTGLDRMRNGEISGGKLVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z625</accession>
    <name>A0A7D5Z625_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HET-E1_12</name>
        <name evidence="3" type="ORF">G6M90_00g100940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987761.1">
        <property type="nucleotide sequence ID" value="XM_066131582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z625"/>
    <dbReference type="GeneID" id="26240676"/>
    <dbReference type="KEGG" id="mbrn:26240676"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="233"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="602" mass="68309" checksum="8A4FA0DE43619EBF" modified="2021-02-10" version="1">MRLLHAPSFELCVFTDDQVPPYAILSHTWVDEEITFNDLSRLRRHDAREKRGWDKIQKSCAVAKSLALDFIWIDTCCIDKSSSAELSEAINSMFRWYAEARLCIAFLSDWNAATDTPASTTFRSSRWFTRGWTLQELIAPREVIFYDRHWEAQFTRDSLRELIRDITGIPKDVLEASKDGGLQSRQRLDGISVAQRMSWAANRTTTRPEDASYCLLGIFDINMPLLYGEGATKAFRRLQDEIIKSTDDESLYAWSCPVEIADKRQFWGLLAAPSRRDHKFWGLLADSPAAFGNYNDMIPRRSRYLTRSSNRTVTVSNRGLRLDLFVTPFPKDTSRTIFLAFLDCDMGRERSSSSLSPVIILQRTAWDNNSDMARIRPDILGLSMMNNVVLPDELATLLCTGSGTGSTLQQPELGQIFIPHKCTSARPPGGIVFHPEVHHPLNKLSLSVRSRSPTWQYFIGMKGSAVERSYEINFEQNPIPAVDELKEPKVLGTIEITIEAGANKTKTKSVCLVVGLEPLAENPFGTPALYFVPWCGFEEQDKIARAELERVLDKTSRRGVLVLGNDVVVGTFGLETRYSRLVFTLKLETKEMRDMRGFTWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6C6</accession>
    <name>A0A7D5Z6C6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g093310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987571.1">
        <property type="nucleotide sequence ID" value="XM_066131439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6C6"/>
    <dbReference type="GeneID" id="90968130"/>
    <dbReference type="KEGG" id="mbrn:90968130"/>
    <dbReference type="OrthoDB" id="10336724at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028938684" evidence="1">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="189" mass="20016" checksum="607A296A77040E41" modified="2021-02-10" version="1">MRIPYILGILCCCIGVTIAQSLSGSASQRSGIVLKALKNLQNDTTKDMEIIRSAISSLKAQSIETRNASSVKVVNDAFNRIIASVNHTTHELASGSQLPKRQVSGFPPLQDASAIAKVLIDITTNIASLFVEALDVFNQSSILIAIGTVIGKALLGLLDVVGVIIRDVPGIQQAIQLVVGILKKVLAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z710</accession>
    <name>A0A7D5Z710_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">samB</name>
        <name evidence="13" type="ORF">G6M90_00g095630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546767.1">
        <property type="nucleotide sequence ID" value="XM_014691281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z710"/>
    <dbReference type="GeneID" id="26241190"/>
    <dbReference type="KEGG" id="mbrn:26241190"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="591"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="326"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI73403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="637" mass="70031" checksum="60E407531A308A9C" modified="2021-02-10" version="1">MREVNFSIPNVNKASVGITTALYDRRALDCTSTLPLINSLNHLAYLTTSSARIRDILTVDGGIERLVCILKQGRSKDMMGMWKWNLAFQCVVNIGVRGTENVRTRVVEADMVPVIATILDNYIKIIEKCREKAEEASQKQIHEHHRRHRGHDHRSSSKPATSFANRSTRLEPDQRSAVRRHGPPPSIDVSASYAGPSTTSAQSTVEAVTAASRATATTPERGATTGTRHRYSFRASDTRQPNPLSAGPALQPLAGATSVVESIDGFVRPVRDSDRLASMALFGHGGNGSQPTSPTTPLPLPQLRSPTVRPIAPSNAAAAAAVAATTALDASDRPRRRPSIRHQTSTVETDDLNADSMPSDESPDADMTGTTEMQSTVGIQDISMEDGESILAGSSLELNTPTVSETHQDPGTFNITHRNAIDGSIGNTTNPTPVPTMGLSPGRPAMVTPPQQPAPNSTVPRYLLDRHVVPTAQMLAVMPREEDVLMSLQLLAYVSKYCGLRSYFQKSHLVPKLSLGINLAALDGEEDAADMEDPDDSDEEYLLPNDFNLFPLVEKFTVRYHSTDMQYWAGVVMRNLCRKDDTRGGIRQCAYYQCGKWEEYTRQFAKCRRCRRTKYCSKECQKSAWAFHRHWCVAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z730</accession>
    <name>A0A7D5Z730_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SCP2_1</name>
        <name evidence="2" type="ORF">G6M90_00g075300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545567.1">
        <property type="nucleotide sequence ID" value="XM_014690081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z730"/>
    <dbReference type="GeneID" id="26241600"/>
    <dbReference type="KEGG" id="mbrn:26241600"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="125" mass="13316" checksum="8104AB2E4B6DEC95" modified="2021-02-10" version="1">MGFANAKFPASAAFDAIDSVLSASDAERKDAIKQANGVFAFTLKNKAGETESWHVDLKESGRVGTGVGKPTVTLLLSEEDFGKLVDGSANPQRLFMSGKLKIKGDIMKATKLDPIMKKAKSKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7A3</accession>
    <name>A0A7D5Z7A3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g059630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544532.1">
        <property type="nucleotide sequence ID" value="XM_014689046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7A3"/>
    <dbReference type="GeneID" id="26242944"/>
    <dbReference type="KEGG" id="mbrn:26242944"/>
    <dbReference type="OrthoDB" id="4939982at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="907" mass="103444" checksum="611B8E2781DCE788" modified="2021-02-10" version="1">MTWNEESAMFDELIRIDQFLNSLHMDKPTETLPSRNLPSEEEISLRAVLLQILFAVVIRLSWLLWRLSMSMCIWILLYFPYIRCILNNRIPFFVGLTAWLVLLTDHDPLSFTTRGRPDGVRFTSADLYQLWYWFAAPILCRTVYHFPCLLRDIHAKAAQDFNDAFEVDISLSEYVVECYKPTPPQSAFDHASRLLLREINLGRIDANIDNPEYDWKTRTLLPQMDGATHLGWDKYSKILDKRKQRRATYHKGPVVHRLRLGPDGQPAADIDGKRRTPSVLIFVEYSHTDKPNFLDLLELSLQKMRKMGTKLNDLRVPSTYGRALIDDLGERCRQNNECIKVSGISLPDLTVEARLGKGAKFLWSTEIPDDQKQDTAYVRASEELELSPIYAANNEKNELTADDYGKKEYVGSPETSLTTDEEMRKGPITLKTDHTQEEDTMAAAGTAIEEHWRVSEMDPDVLDGLPKDVQILPLAECQLTPSPTEQEQPILEENHSKIRYGSEETYRSPENGAVSIEDHQTDPDRFQYTAQKPFTPPAEPDFALRSAPPALRDDRDVDEVIKPGEIQMTIQIQLPGTPESEPTAENLQITVNDGCDSFEDDANFKLNASALTEIISQSNPRSDSNDKERDEAFFQLWEPITQEDGDQDMEDFFEPEFQEESDEMNIDSHEDCDMFDGLYPDVSRGEEWCPYEDTIAMDTDDMEDLVMDTDDVEDPNFQQDVEMINFFDVSKLETMDMQTPGVADRWVQSVTLAGISDDQAAAYTMSQQTPTPIDSCNLMQAMKIADSDPLTSHAKLESAEAVIMGEIDTVSRGSQVADLNDEIEFFSGNGDEEETMSAVQNTEIHEIKEPRKIFHNLDTIISLASATQRMKPVFKQLTKDQLRFSRNSTPRRRKAEKRTGGSIQCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7T1</accession>
    <name>A0A7D5Z7T1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g055250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986673.1">
        <property type="nucleotide sequence ID" value="XM_066130598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7T1"/>
    <dbReference type="GeneID" id="90967793"/>
    <dbReference type="KEGG" id="mbrn:90967793"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="119" mass="13335" checksum="A9F43AF4A0740AEB" modified="2021-02-10" version="1">MTTLYLSLVHAVARLQSQELKDIRRHIKALSRLPEPFLTRLPCQKGTFCQQSCTFVAHVEKFLMLPVHVAQKATGTDDERAAGALAEVGSHSHQYIKLHLQLDNPSTRSQPAPSVHTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z827</accession>
    <name>A0A7D5Z827_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-glycosidase R617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RIBX</name>
        <name evidence="2" type="ORF">G6M90_00g110360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543823.2">
        <property type="nucleotide sequence ID" value="XM_014688337.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z827"/>
    <dbReference type="GeneID" id="26243210"/>
    <dbReference type="KEGG" id="mbrn:26243210"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="192" mass="21729" checksum="587F03A672F4A109" modified="2021-02-10" version="1">MTQSSNTTDNPVYFWRDADTETGWLSQWYYCPFTDDKNPKIVYETAEHYMMYHKALLFNDQAVAAQVLAAGHPRNAKALGRQVQNFSDETWKKHRTAIVRQGNLLKFTAAVTEKGFRKGTGNNAPLIDGSLREMLLATGTRELVEASPSDKIWGIGCKAADAERRRAYWGLNLLGKALMEVRSLLREQTPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z847</accession>
    <name>A0A7D5Z847_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase sdnJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdnJ_0</name>
        <name evidence="3" type="ORF">G6M90_00g092780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541922.1">
        <property type="nucleotide sequence ID" value="XM_014686436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z847"/>
    <dbReference type="GeneID" id="26245390"/>
    <dbReference type="KEGG" id="mbrn:26245390"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="487" mass="54005" checksum="9089AD4178C0C123" modified="2021-02-10" version="1">MADPKRVLMLTNSELGQANVFLAATHELLQLDPNVTIYICSFAPLAQPVSSVRALDETGTADSRLRFIELPGPSWKEALFGRPEHQFQELCAIRPTVWNVSKAAKLTRIACPWTTDELCSLVTRLETIIHDVDPHLTVVDNLFTPAVTVCYKLKPKWVVLSPNTYKEFALAAQPRRQYYWKYPPPRSTIPFPVPWYQMPLVYYMVRKMYLNHDDPFMGQHAKGMKEAIDTDYADWAYISIVPPEGLQILLATRPEIDFPFDVLPGHMVPCGPMVRPCAPLADADPELAAWLASRPTVLANLGTHATYDGRHALEMAGALDLLLRAAEKQGKPLQVLWKLNKGDDFDLSDDTFKGLGQKWNEAVRVTTWLDAEPASILATGHVVCSVNHGGANSFFEAVSAGVPQVVLPVWGDTYDFAKRAEWLGVGKFGSPRHAPRVSARELGRVLKEVVLGPQAARFAEKAASLAKVCGENGGGRRVAARKILEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9K2</accession>
    <name>A0A7D5Z9K2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g076170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545484.1">
        <property type="nucleotide sequence ID" value="XM_014689998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9K2"/>
    <dbReference type="GeneID" id="26241517"/>
    <dbReference type="KEGG" id="mbrn:26241517"/>
    <dbReference type="OrthoDB" id="2402916at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018571">
        <property type="entry name" value="Membrane_anchor_Opy2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09463">
        <property type="entry name" value="Opy2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="434" mass="45475" checksum="2D461A2D96C25644" modified="2021-02-10" version="1">MIGQTPYIIARDLAEVDEILNRLSFDRRDGSCVQCDDRSKLKCPACPAGESCQYTVPVTCSQCAKAFCVGDDSAGNGVQNGGDSSSNSGGPSAGPIAGGVVGGIAAIAIITFLIWKFVIKPKRASNPHHSVYESEINPARHVEKDAASRMTRRSSTHTVHSIASTVLTRASNIIQIAYIPGVTNRATPTSPTVLVPPVPPIPMQHSEGSRHSSQDEQHFFVPGNLRDSTYSGISSFSDRTSYAPRSSIASTIYGKQAQVQTPAQTGMRAKPTVVSVRSAAVGAPGTPPVPAIDFERFGGGRPDSGASNFSVGSTYLNNANTAQHGRAQVVKLGSGLKKIEIAARSDASVSSTSLVSATSSKDSSGAIPIVAESPSNDQGPFSDPPERKVNAISTPTLGAVMEEAEERRGVDKTERPGSGDRGRSPFGDEHATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA46</accession>
    <name>A0A7D5ZA46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pheromone-regulated membrane protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g085550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541113.1">
        <property type="nucleotide sequence ID" value="XM_014685627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA46"/>
    <dbReference type="GeneID" id="26246102"/>
    <dbReference type="KEGG" id="mbrn:26246102"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="813"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="415"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="681"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI72028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="90895" checksum="8D4C59AFE4AA6EC7" modified="2021-02-10" version="1">MASPSESAQDVPGSDAGCEPDPAIHHHTYHHVPADDADNSHNVVQDPIATSPSHPPAAQVTTPLPYPPPASADTAEAAAVAAARREKGRVRFNSNATASKPPVINFEPPPRVPERSATPSPKLRPSILRANSSGSVATAEDLGINLDATSEKAISAAVAQARAQQVAAKVLRDSPPGSRASMDSLATTAASDGGLLPSDSHIPLRNLAADGTAVDSQPQTPENETDEAALKEEAYDLVRTHTRRFASATANTLPADEEVIVSSANVQPSHVNGGLYDGVYNVPPPKRYRGSVLSQLLKLYKPTEPSLHGAHSRNWSSSSPGAVTPPSLESGTATPTSSRKKWYEVNRSQDTLANLVEASTRLANPNKQAPEPKSPGKKRPGAKRRTSSNRLSGFWQKEEARITVHIAETLSRQGYIIKLCRALMLFGAPTHRLEEYLTMTARVLEIDGQFLYLPGCMLVSFDDRSTHTTEVRIVRITQGIDLGKLKDVHHIYKEVMHDVIGVEEGTRRLDELLKAKDKFRAWIRVLVFGLTSATCAPFSFSARLIDLPLAFCFGCLVGLLQLIVTPKSNMYNNVFEVTATIVVSFLARAFGSINEGNLFCFSALAQSGIVMLLPGYSVLCSALELQSRAIVPGSIRIVYAIIYSLLLGFGITVGAALYGLFDNNATSATTCQSPMPSVYTFIFVPFFILCISILYQAKWRQMPVMVLIAFTGYIVNFFSSIKFVASPQIANTLGALSVGILANLYSRLRHGVAAATLIPAIFVQVPGGLASTGGLLSGLSTANQLTNSSTVINGTSTVRFIQGESMNTVVFNVAASMIQIAIGIAVGLFMSAVVIYPLGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA77</accession>
    <name>A0A7D5ZA77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TRM44</name>
        <name evidence="13" type="ORF">G6M90_00g089500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4 12"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987399.1">
        <property type="nucleotide sequence ID" value="XM_066131354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA77"/>
    <dbReference type="GeneID" id="26245475"/>
    <dbReference type="KEGG" id="mbrn:26245475"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="448" mass="50679" checksum="8D2E3303199ADF0A" modified="2021-02-10" version="1">MPFEPEGVPSTALPYFEDSTAETDVWVPYYSHGCTFGPELFSSIMMNMVHNPNINSTWLFRADILYDDGNMDEATTTNISNGVPDTIQPVIRSIPHIPLKRTLVRRLIPRSERRDNPLNQTCTFHFTNESETLVTSLVLYIPHVVSMEHLPFYHPKVRGIAHLHQWSTTSRSGTISVHFLGGSPSDLLDPKLGRIAFHLLEVLHRHGEGAVQGYVKRVHHDRVIPQARFQNRYAELKSKYSRRLVNTWAESTDPGKHVFEDLGIAAFLIELWADMYKGKEFPGFVDIGCGNGLLVYLLTQEGYNGWGFDARARKSWANYTTPTAMSPSGKSLEEKLLLPSIIPAHRDRNNPSQLLHSAHIHDGVFRSGTFIVSNHADELTPWTPILGTISNCPYIMIPCCSHSLTGEKYRPPPPRDKSKPKSTYASLVDWTYTPYYTSTAVLRDTMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAD2</accession>
    <name>A0A7D5ZAD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS siderochrome iron transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mfs1_5</name>
        <name evidence="10" type="ORF">G6M90_00g074710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545596.1">
        <property type="nucleotide sequence ID" value="XM_014690110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAD2"/>
    <dbReference type="GeneID" id="26241629"/>
    <dbReference type="KEGG" id="mbrn:26241629"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="121"/>
            <end position="583"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="589" mass="64295" checksum="13E98D3C03AEF94E" modified="2021-02-10" version="1">MRLPFRIQLARVESVHNYAGVLVPLEEAHLHSKSARSGRTEYESRQDSHDDDVEAGAAEGKNSDSETQGMLQMEAAEYTIEGLRKETRRGRQGQWTEYEIKSKLINKAIGDIGMGTYNWQLFVLCGFGWFADNLWLQGVSLTLPSLSAEFDISEKRVRYTTSALFVGLSLGSFIWGIGSDFLGRRIAFNFTLLITSVFGIASAYAQSWGAVSCLFAALGFGVGGSLPVDGALFLEFLPDASSSLLTLLSVWWPIGQLISSLAAWYFIANYVVDQGWRYFIVSIGIVTFAMFVIRFFIFRLFESPKFLLSKGRQDEAVAVVHGIAYRNQTKTWLTSELLDLVAANDDAGPEPEALGSHLPILSGSSTLSNKLKSFSGERLKPLFQNKTLGWATGLIWFCWATIGMGYPLFNAFLPQYFSHGHDGGQEVPSETSTISNETYRNYAITSIMGVPGSVLAAYLVDSPSPFFGRRGTLAGSTLVSAIFLFLFVIFGKTPTAQLAFSCVAAFSQNIMYGVLYAFTPEIFPAPVRGAGTGVASFLNRITGLIAPILAANIPGDGATTPIYLSAILILSAFVGMCLIPIETRGAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAM2</accession>
    <name>A0A7D5ZAM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247455"/>
    <dbReference type="KEGG" id="mbrn:26247455"/>
    <dbReference type="OrthoDB" id="4935345at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="222" mass="24542" checksum="C18D327F19712299" modified="2021-02-10" version="1">MPRRQRSKVNKRPEIGTLNCSWGMFSKANALFRQYDVDVVVIARRPDGGIGGYQSRPGLARDFLQINEQDLLGPHEVDPYMSKPSKGVAVLRAMSSSRSSSCLDSTENRSSRASSSCVDSIGTETSPGIMEEAEPGVALLNIVRTPHCEEGEGFMEEPLHPWAEVHTIPNAQRCASPETICPIRITKPAKQSSHKTKEDVRQPTPLSRTKRGEILALIKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAQ4</accession>
    <name>A0A7D5ZAQ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR Domain containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g074410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545625.1">
        <property type="nucleotide sequence ID" value="XM_014690139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAQ4"/>
    <dbReference type="GeneID" id="26241658"/>
    <dbReference type="KEGG" id="mbrn:26241658"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58937" checksum="9457F431E4CD770A" modified="2021-02-10" version="1">MSVTAIASFRPLQRRCLVHAATELLSVQVKSRSASWSLRAVVKLQPHQARYQSSAPGNKDEPPKQEKRDRPQMSFRQFVGRSLGASLRNLAVALSPRGIRTAYKDSPVVTSMNIILLAFTLAISVIAIRSYILSFYNSKFSRYPEPVANTLRRAIYYTNYKPDPEMALKYYKKAMEQVKEVGLDPFSDEVLGIRIQVSFWLQKINNYKGSIDVLESVLQDCKRWVGVMEQSVADGKVNEAGRYVDEATGSQPAGSETVTIVPPKDSIAKASETKKDGEAEPEPEVETLWRKRQRLLAKAIGTAVKLGEMYADEHVLQPDKSHDHLVWAVETSLKEFSRRKVDGIKPGEQDWLSPPELGGMMESLGRDYERRSQFQLAVPLFFQALKLCESPCHRAIIMNNLAACFAQQPIFSPNAAEVSVAMQQISDQAALPQTRKECLEAGLNWAQNAYVHGRDVKGDDRTAECDEACAVALCNWGDVAAMLGQRELARQKYRQCIETSQEMEFADGVRQAQEGLARLTTTPDSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBW9</accession>
    <name>A0A7D5ZBW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hsp70 nucleotide exchange factor FES1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FES1</name>
        <name evidence="8" type="ORF">G6M90_00g106670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539882.1">
        <property type="nucleotide sequence ID" value="XM_014684396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBW9"/>
    <dbReference type="GeneID" id="26247321"/>
    <dbReference type="KEGG" id="mbrn:26247321"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="7">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="222" mass="23862" checksum="63EC6E376748A4BE" modified="2021-02-10" version="1">MAQDPRLTELLRWSVEHSDVTLDDPAAAETAASQASRSQLTPEMMAALMGGPSDADLMKAAMELVTAPDADVSLENKLVAWDNFEQLIESLDNANNMANLGLWTPLLEQLAHAEADHRKMAAWCVGTAVQNNEKTQERLVAMGDAGVPALVAVALGAAEREDVRRKAVYALSSACRNYQPAMDVCVEELGKRGFGEGARVDAFDMEAVDAVIHALREKAKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPY9</accession>
    <name>A0A7D5UPY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Mitochondrial respiratory chain complexes assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">YTA12</name>
        <name evidence="19" type="ORF">G6M90_00g004330</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542084.1">
        <property type="nucleotide sequence ID" value="XM_014686598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPY9"/>
    <dbReference type="GeneID" id="26245115"/>
    <dbReference type="KEGG" id="mbrn:26245115"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="446"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="190"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="860"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI63797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="905" mass="100283" checksum="9781BB2E547B4D04" modified="2021-02-10" version="1">MSRYLRQSSQLARLARLSQQTSLHRSLRLPAASRSIPTRTVTGAYGLSVRYYSSSKPPQPDEDSKANKDSTPEIPKNQNESETKTGKEKDSDLTKLAPLPEGWIRLSKDEIAQLDAFQKVLPEAQRATLKDILRGLQQTGAPAEVRDLLAKMRRGPGNLSILDKGRLMRCVFMMAERLAEWEVEEQRKGNRMFDQNQRPDQEQNDAHTGKSEPEFEARNKKPDEGGSHHQGPGGPKKPERNGWMDALQTGLVLGITLWAVDSLSKPFSEKEITWQEMRRAFLDKGLVQKMVVVNGSQVRVELHPDAAQGDAGSNGKRTYIFTIGSVESFEKKLEEAQDQLGIPASERIPVSYEAGGSTIGNLLLAFGPTLLFIGLILWTQRSMGGRAGGGGMFNFGKSKAKKFNAESAVKVKFADVAGLEEAKTEIMEFVSFLKQPEKFEKLGAKIPRGAILAGPPGTGKTLLAKATAGESGVPFFSVSGSEFVEMFVGVGPSRVRDLFAEGRKNAPCIIFIDEIDAIGRARMESGRGFGGNDEREATLNQILTEMDGFNTREQVVVLAGTNRADILDKALMRPGRFDRHIFIDRPTMSGRKEIFKVYLKKIVTNEDQDFLVGRLATLTPGFSGADISNVVNEAALIAARGNAEEVKMIHFERAIERVIGGLERKSLVLKPDEKKTVAYHEAGHAICGWFLRHADPLLKVSIIPRGQGALGYAQYLPQDAYLMNTNQLMDRMAMTMGGRVSEELHFPTVTTGASDDFKKVSQMARNMVTQWGMSDKVGPVFFENDPNRMQKPFAEATAQQIDQEVHRIVDEAYQRCKDLLLEKKREVGLIAEELLKKEVLVRDDMVRILGKRPFEDNNEEFEKYFGGGKEESAPPAPFPADETDTPKEEPPAPAPAFSQHTDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ32</accession>
    <name>A0A7D5UQ32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpn-1</name>
        <name evidence="9" type="ORF">G6M90_00g022220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548332.1">
        <property type="nucleotide sequence ID" value="XM_014692846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ32"/>
    <dbReference type="GeneID" id="26237776"/>
    <dbReference type="KEGG" id="mbrn:26237776"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="8">
        <location>
            <begin position="841"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="898" mass="99660" checksum="D9888A7DAFD99B2B" modified="2021-02-10" version="1">MAQDTDAPKAADKGKGKAVDESKDEKPILNGKKEDDKKDAVEEELSEEDQQLKSELDMIVERLTESNTELYKTALEAMKTSIKTSTSSMTAVPKPLKFLRPHYETLTKLYEEWPAGENKTSLADVLSVIGMTFSDEDKQDTLKYRLLAPTSDISSWGHEYVRHLALEIGEVYGKRITADESTSDLIDLALILVPLFIKSNAEADAVDLMSELEIIEQIPKFVDENTYARVCLYMVSMVNLLTYPDNETFLRTAHNIYMEYKQFTQAIVLAIRLHDVELIKADFDKAKNPTLKKQLAFLVARQRIVLDLPESNDDEQVILECASNLKLSEHFKSLGKELNILDPKTTEDIYKSHLESSRVAGMTNLDSARHNLAAAFVNAFVNAGFGNDKMMLVEGEKESWVWKTKADGMMSTVASMGTLLLWDIENGLDKIDKYTYSAETEISAGAMLAIGIMNSGVRFDSEPALALLGDTEKLHHSNPLIRTACIMGLGLSYAGSNKEDLLELLLPIISDSSQDMQISAMAALSCGLIFVGSSHPDVTETIVTTLMDDERKNQLTDKWTRFLALGLGLLFFGRQEEVDVILETLKAVEHPMAKPTAVLAEICAWAGTGAVLKIQELLHICNEHKEESDDKKGDELLQAYAVIGIALVAMGEDIGQEMVLRQFGHLMHYGEANIRKAVPLAMGLISPSNPQMKVYDTLSRYSHDNDPEVAINAIFAMGMLGAGTNNARLAQLLRQLASYYHRDQDALFMVRIAQGLLHMGKGTLSINPFHTDRQVLSQVSTAGLLATMIALIDPKEFITGTSHYLLYFLVTAMHPRFLVTLDEQLKPLKVNVRVGQAVDVVGQAGRPKTITGWQTQSTPVLLGYGERAELEDEEYISLNGTLEGLVILQKNPEWENGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQP6</accession>
    <name>A0A7D5UQP6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3B subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SF3B2</name>
        <name evidence="3" type="ORF">G6M90_00g008150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985795.1">
        <property type="nucleotide sequence ID" value="XM_066129644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQP6"/>
    <dbReference type="GeneID" id="26239136"/>
    <dbReference type="KEGG" id="mbrn:26239136"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="288"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="599" mass="67103" checksum="373F0329B2215AAC" modified="2021-02-10" version="1">MAAAKMTKNQMRRAKKKEQKKAQKPESTRDSPQEKVEEKHQAKDVADGANHVDSNTNEINSHTAEPPVTIDAPVLDDSLDEDPAFAVYKDIFTKFGASLGEDEVAKEANAGNQGTVFLGDDDGIPDEEEEDEKPKLSKKKRKELNKLSVAELKALVSIPEVVEWHDVSSSDPRVLVQIKAQRNVVPVPTHWSLKREYLSSKRGIEKPPFRLPQFISDTGITEMRDAVLEKQAEQTLKQKQRERVAPKMGRLDIDYQKLYDAFFRFQTKPELTRFGEVYYEGKEAEVDYQHFRPGDLTDATKEALGMPAGAPPPWLINQQRFGPPPSYPTLKIPGLNAPPPPGGSWGFHPGGWGKPPVDETNRPLYGGDVFGLAQNGAQPQATQAQLQTGEAVERALWGELQPREEESEEEESEEESEQEEDADAGGLETPSGLETPSGYSTNLNEYGSGVETSVAGEMDLRKERRGYDTEESSAPRSAYTVLPERQVRAEGFFGSDRAYDVKAGQRAGMPVLGSEDDSRKRKKPGDVDVALDVDSLDQHDGINRDALRQQFEETRRQEGIGAKWAHDDDLTDLIAEESRKRQRTEKERQDKKKESRYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR59</accession>
    <name>A0A7D5UR59_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g001970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542883.1">
        <property type="nucleotide sequence ID" value="XM_014687397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR59"/>
    <dbReference type="GeneID" id="26244256"/>
    <dbReference type="KEGG" id="mbrn:26244256"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="244" mass="26935" checksum="56B89A3BC084A4E4" modified="2021-02-10" version="1">MTYALRGPDGKKVNYDGADIAGSEDQQDLSPTDDADVTSPTASLFSSWSDDSDVSSSKSCDEDGSGPPSSESGDEDDSTSASDKDMSPLGSAKSEVDELLRRLRELTVAMKKSKPNPRLQEADTTFQPTEHEGLRDYLAGIVLARGSEKGQQRCDVGRKSLTPVQDRLIMANLRQRHRFLFAQQDAGNFESGPQNTGRKSTGPFPTANMRYLRPPRLGIGETCFRCPYCCQMLPEMFHMKTHWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URG4</accession>
    <name>A0A7D5URG4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ALG7</name>
        <name evidence="20" type="ORF">G6M90_00g005580</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542204.1">
        <property type="nucleotide sequence ID" value="XM_014686718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URG4"/>
    <dbReference type="GeneID" id="26245235"/>
    <dbReference type="KEGG" id="mbrn:26245235"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI65095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="471" mass="52606" checksum="FA900A0C5A5F4888" modified="2021-02-10" version="1">MRTSSPPNSPTSLSRSETLTLLILSGASLSVLLNTFQGDGEPLIASLALSIIAFSLCYAMIRWLGPTFMRAGFRGRDLSKSTRIEIPECMGAVCAAVYLLTVIVFIPFPFYKDIVAATSGGGNRDVVLEQEHVDHGRFLHRFPHNKLASYLGAIISLQTIALLGIGDDLFDIRWRHKWWIPGLASIPLLVVYFVDFNVTSIVIPVQLQPYIGELFDLGPLYYVYMACIAMFCPQSINMLAGINGIEVSQCLVIAALIAFNDCLYLFTPYPHPATDSHLFSLYFLLPWIGVSAALLHHNWYPAKVFVGDTYCYFSGMVFAVVGIQGHFSKTLGLLLIPQFFNFAYSVPQIFGLVPCPRHRLPKFSARTGLMEPSVTPWSPDRQPHPLVAQGLRLLGKLHLLKVTVDEKGSFVETSNFTILNLWLVWRGPLREDRLATEITLLQLLMGLFGLFVRHKLALLVFKEDNWGTTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URM9</accession>
    <name>A0A7D5URM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">idi1</name>
        <name evidence="14" type="ORF">G6M90_00g023030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548252.1">
        <property type="nucleotide sequence ID" value="XM_014692766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URM9"/>
    <dbReference type="GeneID" id="26237696"/>
    <dbReference type="KEGG" id="mbrn:26237696"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="78"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="258" mass="29568" checksum="01F988DAC8C04180" modified="2021-02-10" version="1">MATTTVTVTETRTEPMTADTILRLFPDIDTSSEALSGHDEEQIRLMDEVCIVLDDNDMPVGKASKKLCHLMSNIDKGLLHRAFSVFLFNDKNELLLQQRASEKITFPDMWTNTCCSHPLAVSGETGSNLPDAIEGAKRAAQRKLEHELGIKKEQVPIEKFRFLTRIHYKAPSDGKWGEHEIDYILFIKTNVDLKPNPNEVQATQYVSADKLKKLFEDPSLKFTPWFKLICNSMLFEWWASLDSGLEKYTNEQEIRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTP7</accession>
    <name>A0A7D5UTP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g045790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544706.2">
        <property type="nucleotide sequence ID" value="XM_014689220.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTP7"/>
    <dbReference type="GeneID" id="26242047"/>
    <dbReference type="KEGG" id="mbrn:26242047"/>
    <dbReference type="OrthoDB" id="4890633at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046839">
        <property type="entry name" value="ABC_toxin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20220">
        <property type="entry name" value="ABC_toxin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC toxin N-terminal" evidence="1">
        <location>
            <begin position="394"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="450" mass="49187" checksum="9EF3BFB2DE69D656" modified="2021-02-10" version="1">MLSPSVAKDVVDVVEGTASITITNNSITISVLAQTFRLNVSDVIVAFKELVPDSKPNDREQKIATRRKQGMVWMVPELKRRATDTLVTDSLATRFPDAPSQLVQQLLAAKDPTPLPGVPDPTNATYLQSLKGFYTSLKDYWSGATIAIRGQDCPFTSIPGPDVKRFTTPQHLQQGNVALVEWMDGLQLEYLSYSTSGGEVSLKDSLVCPIKLASLVCLTLGHLGRCMDVAKMLSLEPEEVGFHLGQGINFSRVDVAKLLRLRSFANIRTQFSTSGVATLIAYVKYLERLSNGLKTDTIDKLVAEKKQLTLIDASDNSAFFTTCWPMAIVKDLAKTFFDGDLYSLQQLTEACSLSKDLGVPITTLQELKTALSSSSASTSGGALARAKEVVIPRQQHVLQEYIIRLPVFVNRGIITTGDLSADFLMDLQMGPPMETSRIGQAIASAQFFIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU65</accession>
    <name>A0A7D5UU65_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase swnN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">swnN_1</name>
        <name evidence="5" type="ORF">G6M90_00g032290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543164.1">
        <property type="nucleotide sequence ID" value="XM_014687678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU65"/>
    <dbReference type="GeneID" id="26243965"/>
    <dbReference type="KEGG" id="mbrn:26243965"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="35603" checksum="66E6579EC47221B6" modified="2021-02-10" version="1">MVVVAVAGGTGGVGRTVLDAIAKSGQHQAIVLSRTTSISTAVDEPERFAVDYNSVEQMKQILQENNVQVVVSALLLVDEAVAQAQINLIRAAAQSGTVTKFIPSEYYIDFHAPIPGADLFTNFQLEAEAELARHAQLTWTLIRVGIFLDHLTMPHNPKTTYITPFWVFVDIDHEQCVFPGDGSQPLVLTHSQDLAAYIERLVGLPAENWPRESVVASNKLLVKDLESLVNKVTGKKFKVAYDSVEDIHKGHITQLPSNTAVFQDPAKGEMFRDVERQVMLSMLSRAHDLPGKNLAELFPEVETTDIEDFFRAGWTLKQSRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU99</accession>
    <name>A0A7D5UU99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RRG9</name>
        <name evidence="7" type="ORF">G6M90_00g034180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543345.1">
        <property type="nucleotide sequence ID" value="XM_014687859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU99"/>
    <dbReference type="GeneID" id="26244146"/>
    <dbReference type="KEGG" id="mbrn:26244146"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="306" mass="35361" checksum="2901BA8FB0FC75C6" modified="2021-02-10" version="1">MKCPCRAAPWRIFLQSLAQVHNFPVSTSTARPWRPAPVPRPVSSQRRGLAASSYWRRETTRSAVAAENAVDKRENVTGTAAETKPLRKNRARDKKTENEAPSAKEFQTRTIEKSSPPSPPPKRRANKAKPHDQSPDLNIAQPKTPEWQSQKAALKEKFPQGWKPRKRLSPDALAGIRALNAQFPDTYTTRALADKFEVSVESIRRILKSKWTPSVAEEQERQERWFRRGMQVWERKAAVGMKPPRKWRREGIVRDSWWHERRKEAARREREWEEEEKEAERARRNYGARSVGGEDEGRGEAGSGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV80</accession>
    <name>A0A7D5UV80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g046850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544808.2">
        <property type="nucleotide sequence ID" value="XM_014689322.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV80"/>
    <dbReference type="GeneID" id="26242149"/>
    <dbReference type="KEGG" id="mbrn:26242149"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="9">
        <location>
            <begin position="129"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="752" mass="82727" checksum="147038ECDB89AAD9" modified="2021-02-10" version="1">MEGMDDDVSLNTDQIRDWRSIMTLIVFILTNINVLFPFHIPILVPRMAWNALVNALSYVRIIPPRNATFPYDADDDNDNGKVKPYVRLNFPMNFVTAPLIADLFLLAILAIGRKEVHDGILGADHISPIDIMAFFITLAYIAISIDASGLIRYLAFKVLQWGGKVGHRLFFFLYSFFFLIGSFIGNDPIVLSGTAFLAYMTRVSSNIVHPRAWIHTQFAVANIASAILVSSNPTNLVLAGAFQIRFINYTANMIVPVVVTAVVLFPFLLYIVFANEALIPYSIEMHELPPEARTKKPVNPNIPHARGPMEEDENSTSNDEQTKVLSLEEIMNPFLDKGGAAFGAVIMAATLITVLVINAVSTGTEAHPVFWVTLPAAFVMFCWDIGFGWFHRAETRQIARRGRLELETAREERALRERDQARFSETNAATENAHTYELKEPLSKSGNAAGTMGGKPMLPSPPAILVSQNTDGATIATSSESESITSQPVPAAENATDKHISNGEKTAKFQNTKLDRTTSVTPSPNLFISSSSGEVGEDGRDSRDLPFTKESGPATLTSLSKNGLRWCRETFPTAAAVILHLPFALVPFAFSMFVLVQALVTKGWIPVFAHGWDHWVKKTGTVGAIGGMGFLSVVLCNFAGTNIGTTILLSRVIQAWQKINIVNQTDISDRTFWATVYSMAIGVNYGAFSTAFSASLAGLLWRDILSRKHIHVQRLEFARVNLPIIAIAMIVGCAVLTGQVYIVRSDKPYNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVH3</accession>
    <name>A0A7D5UVH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g048490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67855.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13424" checksum="9E071C950FADA688" modified="2021-02-10" version="1">MQQPLGTEQGLKVLPKIMSDPQQTSVRFMAIIFGSNDACFPDAENGEHVLLDRYKKNLVKLFTHPALEAHNPRLLLVIPPLIEERRLDHRVKSRGYLKLNRSNVVTEQYADTCGEIAK</sequence>
</entry>
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    <accession>A0A7D5UVJ7</accession>
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            <fullName evidence="7">Protein AAR2</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">G6M90_00g041830</name>
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    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547525.1">
        <property type="nucleotide sequence ID" value="XM_014692039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVJ7"/>
    <dbReference type="GeneID" id="26240088"/>
    <dbReference type="KEGG" id="mbrn:26240088"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="114"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="310"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58147" checksum="B746238C0AAEE036" modified="2021-02-10" version="1">MDAKGASASTPRGIRKSNSTRSAGAHSTTSHESVRVVGVHPLGTLRVLGPESSPRISEQNDVEDDDDQGPPPLESPVENAYGLSGNQHNSPQSSSASPTKRSRDPQAHEMGGGDVAVILDLPDLFVVAYDSVSFTAQNFVGVRDVQAGPHFFWVAHPSGVAARDGVWLLGSESQNHVHVVQWDSYNEMLTEATRSESRNSAESMPNIHAQLVPYADPSRLTEGGGQLSVSQVERNRRIWNQLTTHVNATVLNRITGPQVGGWIVHTLDRAQGALKFSPEVELERAVPNRNLQRRELHFAFQSTTRLFSIESLGSERTREATDPSIYLMSQIEDTKNNLVYDDLLGEFQFAFVVGVHLGNDASLEQWWFMLLKLLVKSHLLVQGQPVLVASMWHTVAAQIAYSSQWMESSVLENNDTRCRELRIALIIYKRRMEEFLSDDENIVTPDHLAVSTAFSRLEAVLTDIGWDLSGDYLRKGIVVMEDGEEVELELTDLEAEDERGEWAPEFVELDENGRERGLISWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ2</accession>
    <name>A0A7D5UVZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g030900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539649.1">
        <property type="nucleotide sequence ID" value="XM_014684163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ2"/>
    <dbReference type="GeneID" id="26247560"/>
    <dbReference type="KEGG" id="mbrn:26247560"/>
    <dbReference type="OrthoDB" id="4941382at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="352"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="599" mass="62632" checksum="D5E7BB1FE8D58054" modified="2021-02-10" version="1">MSSNEKSGESAAELSGNTYYPPPPPGPPPSQQGPPEQQQQQQQHLQQPLAQQYQPHPQQQPDQQQYFPPPPGPADEKQPHVQQQQQQQQPYFPPPPPAPHAVDETQSHQQHQQQQQHQQQQQQPSFPPPPPASADDKQSYQQQQSAYAIPAYNPANPAFAPPPTAQHDAQTPTGHPGPASSYAHQQPQQPQHQQPPQQQPSQTAPKKSGWGDRFKHFVSAGAAAPINSLAHKLGSQSFLPETLDKECDKSAAILRSFCTKGVYADPGAGQPPTSTDPKAHESSSGVIDPTKEKPKNRVIVTIPPKVISKAVGLAIFTTLRAGFQVSGATGSGVLIARLPDGSWSPPSGIQVHSVGGGFQIGLDIYDCVCVINSREALAAFMNTRVSLGSDLAVVAGPYGAGGAVDFGTAVQRGRDDKDSKATAASDAQPAAAEAQPSSALKPDAGAASKDSKRRSLSTSAFKPVFSYVKSRGFYAGIQVDGTVVVERKDANASFYGAPVTVQQILQGQVPPQGPRDMWPVGARALLETLRGAEAGALGHHSSASASASASGAAGHPGSGAVPWANAPPAGAAPGEASSGAPPAYVDDGSHAHVGDAKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWX0</accession>
    <name>A0A7D5UWX0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RPC11</name>
        <name evidence="14" type="ORF">G6M90_00g060290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWX0"/>
    <dbReference type="GeneID" id="26243011"/>
    <dbReference type="KEGG" id="mbrn:26243011"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
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    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="66"/>
            <end position="108"/>
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        <location>
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        <location>
            <position position="5"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <position position="70"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <ligand>
            <name>Zn(2+)</name>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51133"/>
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        <source>
            <dbReference type="EMBL" id="QLI68838.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    <sequence length="110" mass="12574" checksum="1261AB406A87F928" modified="2021-02-10" version="1">MLLFCPQCANILTVSLTNQRTNRLECRTCPFEHTITEPVFSRRVFERKEKEDVFGGPGAWDNAQKGRAQCPAEGCDGDEAAFFQVQIRSADEPMTSFFKCMTCGNRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX21</accession>
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        <submittedName>
            <fullName evidence="11">Conidial yellow pigment biosynthesis polyketide synthase</fullName>
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        <name evidence="11" type="primary">wA</name>
        <name evidence="11" type="ORF">G6M90_00g031450</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
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        <property type="entry name" value="Ketoacyl_synth_C"/>
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        <property type="entry name" value="PKS_MFAS_DH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="375"/>
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        </location>
    </feature>
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        <location>
            <begin position="1657"/>
            <end position="1731"/>
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            <begin position="1298"/>
            <end position="1434"/>
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            <begin position="1460"/>
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    </feature>
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            <begin position="1620"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1729"/>
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        <location>
            <begin position="1730"/>
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        <location>
            <begin position="1740"/>
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        </location>
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    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1523"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50075"/>
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        <source>
            <dbReference type="PROSITE" id="PS52004"/>
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        <source>
            <dbReference type="PROSITE" id="PS52019"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI68439.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2075" mass="223573" checksum="6C4EDCDAD4A0A36C" modified="2021-02-10" version="1">MAPRFQVIVFGDLSVPYHAELQRLLSDKDSCTLVSLFSDAHRALRSEIARLPPSQRSCFPHVSNLAELLIARQSSQVPNCALDSALVCLCHIASFIAYTNEPGRCYPQSSSSCLLGSCIGLLAAVAVSCAENVLDLVEAAPHFVSLAFRLGHMVQNRTTSVVSGTDVHSSCSSVVSGVDEETMPPRIEAYCVSRGLAALSRVYISAVGSGSVTISGPPAHLKEFLLHNPAFKAGKIGVAGLFHSCCLYTRADVDALVSGVGVHTRSRAVRLHVVSNSEEAGEGSCEATCEELLQRAVAEVLLRRLRWDLVIQRAVGTLESSKLSEADIIPFASSSVESLATALRASEAVESLDVLSTLPLSRSEGSSVSGPKSNRSKIAIIGFSGRYPEADSNEAFWELLAAGLDVHKEIPKDRFDPWLYYDSTGKKKNTSGVTMGCFVRNPDLFDSRFFGMSPREADQADPAQRLALMTAYEAMEMAGFVPDSTPSTQRSRIGVFYGTASDDYRETNAAQNIDTYYVPGGSRAFLPARINYHFRFSGPSFDVDTACSSGLAATHIACNSLWAGDCDVAIAGGTNILTNPDNWAGLDRAHFLSRTGNCKTFDDGADGYCRAESVATVLLKRLDDALLDGDPIYGTILGAYTNHSAEAVSITRPHSGAQRAIFSRILTSANVESSRVSYVEMHGTGTQHGDACEMDSVLNVFAPEGSRRDETLYLGSVKANIGHGESASGISSLIKVLLMMQKSSIPRHVGIKTKINRNFPLDLARRNVHIAMKDTPWPRPDPRDAPSGRIAFVNNFGAAGGNSSVLVQDAPATSAAADDDPRPLHIVAVSAKTQTAFKNNLAALEKYLDAHPDVPLGSLSFTTTARRVHYGYRAAVTGSSIRDIREALASAANADKCLSTAGSTTPVGFCFTGQGAQYLSMARELLAHPQFLSLVTGLEDVVRLQGFGSILDVLQGMADDPMEQLSPVKVQLAMSCLQMALGKFWMALGASPDVLVGHSLGEYAAMNVAGVLSDADAVHLVGTRAALLSKYCSVGTHAMLAVKASADRVASLLGRPGLEIACVNGPEETVVAGPRDQIDSLAAVLNTQSVKTTLLKVQFAFHSAQVEPMLESFRQSCGSVRFKDPAVPLLSPLLGKVVRSAADLASPADYLTRHCRETVNFRGCLLSAAEAGVVSDKTVWVEVGPHPVCGNMIKSTLGASSRTFPSLRRGEADWKVFTSTLTSLYNSGLAINWGEYHSGLTHNKQVLCLPFYKWELKSHWIPYVHDWCLTKGDAPPPPQPLASPAPVARQKPLTTSVQDIIHEQYSGDEAQITARSDIQHPDFREVLLAHKVNGQPVCSSAVYADMAMTLFTRLLEQSAVGFDKSDIGVEVSDMSADKALVLNDDPSHLLEMKAAVKWSTRRATFTMSSISSAGAETAHHARCTGFFVDKSQWRADFKRRDFLVRARIDDLRRSVHDDSGSVHLIKTGMFYKLFSALVDYRPSFKGCRELVMRSAELESSARVKFNTPPGTADKWMTPPYWLDSLGQITGFTMNANDEVDSKNQVFINHGWENMKLLEPLSQDVTYTTYLKMRPKDKGSYIGDVYIFNEGARDIVAVYEGVTFSAVQRSILDKVLPKPKPATAKPVPSQPVFGSQAPAADDEPSTEPPALLPPHKYGVPADKLKAIIAEEVGAPVSDAQDGAELAGLGVDSLLALTISDRMLEELGVKVDSTAFITCKTVGEVIQLIAGSSTPSSDSEPSTPPVTPPPPREPEFENAHLSRGVEAALSALSMDPDEYTPIASMNDKAKPTPAPAFGVVSPLTVLPPPSHVPPASSVLLQGNPATCSRKVWLFPDGSGSATSYLPLPDVDADRVAVYGLSSPYVRRGDCKPCRFEELTAAYVAEVRRRQPAGPYIVGGWSAGGICAYDAAQRLAAEGDAVDGLILLDSPRPVRLKKLPPRLYAELDRLDVFGSGGRRPPAWLAAHFVLFADILDTYRPRGWAAARPLPTWALWARNGVDEGGLIDIWPGDPDNLLWLLHRRAVVDANGWDELVGGENVVMDVVEGAHHFNMLKEQGARQVTDFLRRAVTCMAGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX50</accession>
    <name>A0A7D5UX50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g058740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544448.1">
        <property type="nucleotide sequence ID" value="XM_014688962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX50"/>
    <dbReference type="GeneID" id="26242860"/>
    <dbReference type="KEGG" id="mbrn:26242860"/>
    <dbReference type="OrthoDB" id="5400539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="160" mass="18368" checksum="417038BAE6C5D159" modified="2021-02-10" version="1">MAVAARDVVYANGDYFYVPWWHTKTGVIVRWVIFLVFFALVMGYLIGGYYHAKARIRKGLQPLAYHRCLVSRRSYQPTYQEQWPQYQYSHYPPQQNGQQNVYPMNDMPLPAYDPNRPPMYSGPPGGSKVDPSQNRASTHRMTEDNPAPEYAPPTGAPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXE5</accession>
    <name>A0A7D5UXE5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g032550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543186.1">
        <property type="nucleotide sequence ID" value="XM_014687700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXE5"/>
    <dbReference type="GeneID" id="26243987"/>
    <dbReference type="KEGG" id="mbrn:26243987"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF8">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="32785" checksum="152B74A73E58C83F" modified="2021-02-10" version="1">MGSVKGPLDSAPVGKIVSSNQDPKAEFSNDATATTTVPTTKPNQNEVSRKLSANVSVIIFPGAWHPASCMSSFVSSLRSIGLPTEAYTLRSVGDASAGVAADVDYMRSIMNPLIDAGNDVVVVSHSYAGFPTTSAISGMDKRGREARGEKGGVLGVIYLASFVPQDDDTLHGVLGNQWPPWIKEDETEQFIICSNEGHIFYNDCTSEQGEAVTESLKPHSLKASKGKDAIPNNIGWRESGYDGRRGYIRLTEDNAIPLSYQDYLISRSGVNWSVKTLNASHSPFLSMPDATAELVHELAQEFLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXX5</accession>
    <name>A0A7D5UXX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetoacetyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AACS</name>
        <name evidence="3" type="ORF">G6M90_00g062020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542672.1">
        <property type="nucleotide sequence ID" value="XM_014687186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXX5"/>
    <dbReference type="GeneID" id="26244621"/>
    <dbReference type="KEGG" id="mbrn:26244621"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="112"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="699" mass="77155" checksum="64C84ED75970CDF4" modified="2021-02-10" version="1">MDFEQTPRKLWEHPDPKSTAMWAFMQDANAKYGLDMQDFPALYKWSCSHRNQFWSLVWETMPLIHSGSYTQPVDESIPVSQLPAWFAGIQLNWAENFLWSRSANDAPGTRTQLNKEDSKIALTEVREGNTEVRHMTWAELRRRVAELATAMKERGVGRGDRVVMVGAHSATTLIVFLATTWLGGLFSSSSTDMGVGGLLQRTAQIDPKYVFFDDGASYNGKTIDLRDKIQGVMEGLQSCPSFNKVVVVQRFKGQPYPTGHIANTERLEDFILSKGYKQPPPMVRIGFQDPMIVYYSSGTTGIPKAIVHGVGPLLISIQKEGILHKGTTPDDVGLQFTTTGWIMYLSSVSQLLLGARAVLYDGSPFVPDATVLLKIAEQQGVTTLGLSPRWMTELMKKGISPRKVADLSKLRKVVSTGMVLPDQMFEWFYDEAFPPEVHLANISGGTDIAGCFVLENPLTPVHVGGCVGGSLGVPIAVYDHDLADGSEGKPLPAGQAGDLVATAAFPNVPLFLWNDDAPSPGKKYRGAYFDRFDGAWAQGDFCVFHPKTGGVLMLGRSDGVLNPSGIRFGSSDIYAVLERCFPAEVAESLCVGQRRPGDLDERVVLFLIMRQGRTLDRKMVTSIKDTIARELTKRHVPRYVFQVPEIPVTVNGKKVELPVKSIISGKTVKPSGTLLNPGSLDFFYRFQKVEELEEPLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY51</accession>
    <name>A0A7D5UY51_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g064740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540071.1">
        <property type="nucleotide sequence ID" value="XM_014684585.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247107"/>
    <dbReference type="KEGG" id="mbrn:26247107"/>
    <dbReference type="OrthoDB" id="4959772at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF10">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 29-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="346"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="637"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="865"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="898"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="931"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="976"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1042"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1109"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1312"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1345"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1412" mass="156296" checksum="4CF36756D62C29DD" modified="2021-02-10" version="1">MLAALRYEDYTIGWICALHVEALAARFMLDKRHDGVFPGRHGDDNNYIAGSIGSHNVVLAGLPTRSIGTVPAAILVSQMRQSFPNLRYGLMVGIGAGVPGRHLKPDVRLGDVVVAAPTEDSDDVQCVIGYELGKETAGGFIKKNWLYPTDLRLRTAISTIQTETEFTRSHGFLKHLDVFQTKPEGRKFLFPGVDNDQLYEAEEADDKYSLVARNPRDSQDPVVHYGRIGSGNKVIKNAKLRDELRDKYNIICLEMEAAGLMNTLPVAVIRGICDYADCHKNDTWRHYAAATAASYAKELLYAIGADPPANPRLGGVLCADETKFLQSLYKSDYKSHGKRNPDRVPGTCEWFLRHPKYRRWRQERQSSLLWVSGDPGCGKSVLVSFLLGELKSDKSQAILPGTVCFFYFKDDNDKQNSATSALCAILHQLFTTKKFLVKHAMPEYENKDQKFTNEFSTLWDICTTALNDADCGNFICVLDGLDECELLTRNLLIDSLIKFFSASGSRDTNSFSKFIVTGRPYGTIERRFHSPRTTAPPTIRLKMEDETTAISRDIELVVKAKVEEIGHIKSLPASVRADLQKRLISNADRTFLWVSLILQMVEESARVSRAAVNDIATTIPGTLHAVYDKILRHVSNDEASRKLLHIIVAAVRPLSLEEMNVALNITRCDHLNEDLDLEPSIHSTIKELCGPLVKIVNSKVYLVHHTAKEFLTRSNGEKDMSLGPWKHSLYLNESNLILTEACTWYLLFSHFQDHPLEINLRLPSLDIESQVDQYARRHNFLDYAAKNWATHFQQTGIQENALLKKTILDVCDSQSQRFRTWFWVYQSNTDVYFPPCTCPMDPMIRSSFRVEVIKRSLQPKKAFKSPWIALHWAARSGYSAVVQVLLENGASAASKTHSGWTALCWAASTGHRDIVKLLLNKGADVRTKTAFGWTPLHLAVGNGHMSVVQLLLENGSEIDAKDPDGCTASHRALDMGRNTLLHSAAASGQEEIVRLLLRNGANMASKAENGETALHKASASGSKAIVRMLLDGGAEINCSDNAQRTALHYATKVGDEDIVRLLLDGGADVAAKDMCGGTALHLAAESGNEATLRILLETGIDVMERNALSGETALHRAAGNGHDTVVRLLLEEGALVNAKDVYGGTSLHWAFDSENGALIRLLLKQGADTNATTINGGTALHRAAWNGNVTAVRMLIENGVDIYHENRIGETAAMLAVMPGYEDIVRLLLKQPTRDLGDDMIAMNAAGLPHLKWAARRGHKAITELLPMKGVDVNESDFIGLITLHHAISSGNKKMVLILLEKGTDVNTRYLTGRTALHEAVLTGNREIVSLLLEKGADINAAYQGGWTALHEAVLTENKEIVSFLLEKGRDINATYQGRWRALHEAVSTGNREIVSLLLEKEPRNDMVYLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY80</accession>
    <name>A0A7D5UY80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g062590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542622.1">
        <property type="nucleotide sequence ID" value="XM_014687136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY80"/>
    <dbReference type="GeneID" id="26244571"/>
    <dbReference type="KEGG" id="mbrn:26244571"/>
    <dbReference type="OrthoDB" id="5139907at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="411"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="770" mass="87218" checksum="60319A49E59D17D7" modified="2021-02-10" version="1">MPLTEQQINVISEHPLNDTLDRFRDKLRDLDEADRSWRDATASIILALVDTGAALNLGSRGGKETLADDLFPLYPGVRKGSFKSEHFRRLARCIIDKASDIDIWETVFSVVESLSALTPPGSSIAPTFKGTPVKTSSSRLADSETRDVVEGELFEEIKNCTFRNVKGFCDKFFDPKSWRQEQKAMLRAMMTAHDGKKWTEFPSTTDERPVWDWLCLLEERFLADAPHRLHTTRTANQFKERKGQMDVFLQTPVTNANDTFEYKHVLVVGEQKKSNDTGRFKATLLQLARYVRGVFADQPTRRFVHAFSLCASTMELWVFDRSGAYSSGPFDIHDEPDKFARALVGYATMDDDAMGLDTFIERGDACRHVTLDDASGNEMRVRLDKAMVRQWAIVCRGTTCYETQNSQVAKFSWASDKRKLESEQLKLAEQRGVKGVARVVAYRQITTIAELRDGLEFPKHHKFRNEANFSEDLPSATASTHTSDHKRKSSDDDASDNTSESKKRRPNSQKSKLCTEFNDQLSIGKAKPSLYMPGEDPWENRIYSCLVVSPAGRVISDFRTIKELLESMRDAIRAHQSLYTVGNILHRDISSNNIIITNPETADGFRGMLIDLDLAKVRDSGPSGARHQTGTMQFMAIQVLRGVDHTYRHDLESFFYVLLWMCARCSWSNRFGGEEKPPRESLLRKWGIGSFKDIANAKGWHMTVNGLEEVMDEFPDIFNVVKPLCLKIRSIMFGETARLNVGTPAGNPDQLYNDTIVAYDEAIDELLEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY99</accession>
    <name>A0A7D5UY99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PPT1</name>
        <name evidence="10" type="ORF">G6M90_00g070930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545962.1">
        <property type="nucleotide sequence ID" value="XM_014690476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY99"/>
    <dbReference type="GlyCosmos" id="A0A7D5UY99">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="GeneID" id="26241995"/>
    <dbReference type="KEGG" id="mbrn:26241995"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028872991" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="37326" checksum="F15B68DFB524F04F" modified="2021-02-10" version="1">MRTSSLLATTAVLGCSLAATTRRPKANSKSAQPSYDDSDNPLPLVIWHGLGDDADSEGLAEIAKLADDIAPGIFVHIINPTPDGSDDRTSTFIGNVTHQVQIVCDQLAKNRVLSTAPAIDAIGFSQGGQFLRGYVERCNFPRVRNLITFGSQHNGITEFKQCGALDYICKAAMALLRFNVWSTFVQNRLVPAQYYRPVEDSDYALYLDGSNYLADINNERDKKNETYKENLVRLDNFVMYLFENDTVAIPKETSWFGEVQVNGRHTPLEERKMYKEDWLGLKTLDRKGALSFRTIKGDHMHIPEHVFKDVMTEFLGPFNKTAVSVDGFESEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYI4</accession>
    <name>A0A7D5UYI4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3669 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g058340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544411.2">
        <property type="nucleotide sequence ID" value="XM_014688925.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYI4"/>
    <dbReference type="GeneID" id="26242823"/>
    <dbReference type="KEGG" id="mbrn:26242823"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022137">
        <property type="entry name" value="Znf_prot_DUF3669"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40780:SF3">
        <property type="entry name" value="DUF3669 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12417">
        <property type="entry name" value="DUF3669"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3669" evidence="1">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="38201" checksum="D215056664839AC0" modified="2021-02-10" version="1">MESYRSLTASNKPLLMMSSGQCGSVWGMAMLHRHRHHSVGVVIKREHAGPGRYLKNEATLQRQIFTAAWSLKLTSVPQCFHLVDQEDDERWRDLLLILPAGQGKCTTMIAERITAVSRQAQLLLVKKYNWTSTRHRLMQTLESNAYYTHCLVHLYLGRRRSCSLGVPATRPQVFTLCNFPLHADQMEELQLPCPKYAKAMAESLAMLHWEMRLSGARVKFVLGGRRGAIRMSASTPLAESTVWMFDFDRLRPIQANVSGLISIARAFWRNSPYCPRPDSTLWNIFADEYRRVGKEKVQAYPRHGECVETLCDLVDGALNMIAMGQKMWTIRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYY6</accession>
    <name>A0A7D5UYY6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypoxia up-regulated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hyou1</name>
        <name evidence="10" type="ORF">G6M90_00g071870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545873.1">
        <property type="nucleotide sequence ID" value="XM_014690387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYY6"/>
    <dbReference type="GeneID" id="26241906"/>
    <dbReference type="KEGG" id="mbrn:26241906"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000004">
        <property type="entry name" value="hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028995226" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="812"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="929"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="946"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1001" mass="108734" checksum="9F736A7973C00EFF" modified="2021-02-10" version="1">MANSRPSPLMMLLGAVIFFSANVFASAAVLGIDIGTEYIKAALLKPGTPLEIVLTKDSRRKETSAVAFKPLNSGPKAAQFPERLYGAKAMAVAARFPDEVYPNLKTLLGLPVDDASVQEYAARHPALQLQAHSTRGTAAFKTKTLVPEEDAWLVEELLAMELQSVQKNAQATAGHGSSVRSVVLTVPSFYTVEEKRAVHLAAELAGLKVLSLISDGMAVGLNYATSRQFPNINAGEKPEYHLIFDMGAGYTTASVLRFQSRTVKDVGKYNKTVQEVQVLGSGWDRTLGGDSLNYLIMDDMISQFVETQAAKGISATAQGVRSHGRTMAMLAKEAERLRHVLSASQNTQASFQGLYEDVDFKYMVTRDDFETMSEAHAKRIEAVINDAIKMSGIELSDMTSIILHGGATRTPFVQKALEKAAGSADKVQSTVNSDEAAVFGAGFRAAELSPSFRVKEIRIFEGPMYAAGLKRANGEKRQRLWTAISPLGGVAKEITFNDHDDFALSFYQQVGDDDRDIASLSTKNLTATVAAIKEKYPSCVESEIVFKLGVKLLGENGEIQVVRAAVECEAEVTVKERIVDGVKNLFGFGKKDQKPLKGNEKNADSKKPEGSEEAPKAEAKSSATSSSSTTDSSTASSSSESAAPSEEVREVKQKQTVSIPVEVVLEKAGAPTLTKSELVKAKDRLKAFAASDKAKVQRAEALSQLEAYTYNVRDLLDGDSFIDASTEKERADLAKQSSEIGDWLSGDGADATTEILKAKLKILQDVVVPVQTRIEEAEKRPGRITALKDSIKRISEYLDSIHKQIAEYEEWEATASSASASGSSTTSASAETPTGEFDGLEDDDAKDTKNDNKPEEQPGPIPPLFKKEELKDLETLVKTTSEWLSKMQPQQEKLPSNANPVLLVKDISEKIQKLDKVSMDLALKGAKGFGGKAKKAAQNLKKGKSKKGEGAEDFKGQRFTEDQLEEMLEKIKAMEKEKKPEKTEKTEKAKESSEKPGHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZB1</accession>
    <name>A0A7D5UZB1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g068720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987142.1">
        <property type="nucleotide sequence ID" value="XM_066130886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZB1"/>
    <dbReference type="GeneID" id="26247240"/>
    <dbReference type="KEGG" id="mbrn:26247240"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="233" mass="26388" checksum="76997594D62DCED2" modified="2021-02-10" version="1">MDLTPIKVAAVILERHGISMCIVGELALNYYNVPRVCHDLEICVPKSSSRVALNLLCSTGLFSYCELDGDFNNFTEYKRNVPRVRTTGWCPPQTIVIFTAAFFGFDSIENILISPMNEGDTYFSKEMQLNREDITNLHLPRLAPLLKGLARRFLDTKDDVAMIAVEQLVDGMDIDEAWVERHLGGSDAALLDLVKSQIRSKKSRIDYYTDNKITCFVSDQEEAEKIRLIPAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZF0</accession>
    <name>A0A7D5UZF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 52A3-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CYP52A3-B</name>
        <name evidence="14" type="ORF">G6M90_00g072530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545810.2">
        <property type="nucleotide sequence ID" value="XM_014690324.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZF0"/>
    <dbReference type="GeneID" id="26241843"/>
    <dbReference type="KEGG" id="mbrn:26241843"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI70698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="509" mass="57935" checksum="D4E5EB570B7D247D" modified="2021-02-10" version="1">MSIMREIRSAPSWITIVAVGVFAFSLVWIRHKVAGVRIQLAGGTRAPVLAANLLSATKLYIDIGTHQYNNKLAQWCNGILDSKQSNYAEFSLTGKKRVLITREPEQIKAILATKFANFGHGPQWHRLWRPFLGKGIFATDGDDWHRSRGLIRPMFVKDRLRNLVIFDNCTRKLLSTLPPSGTTVDIKDVFYRWTLDTTTEFLLGENTNSLDNPHNEVAEAMSVAQRIQMYIFVLNPIAPLIPKGDYYRSIRKLEEFIEPIIQRAISLPQHELEELSKIDTQYTFLHSIARVTKDPKIIRDEIMSVLLAGRDTTAATLSWAMYEMAYVPETWAKLREEILNELGPHGMPTYETLKNIQYLKNVLNEVLRLHPAVPINMRQALEDTVIPGAPGQPDVALLKGDTVTINTIGMHARKDLYPPISKHFADPAIFSPERWEHWIPTPWTYTPFSGGPRICVGQNFALTEMAFCLVRLAQTYERLEYRGDWHAQRLRADIIGTPALEVPIALFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V097</accession>
    <name>A0A7D5V097_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARB-07466-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g064630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540080.2">
        <property type="nucleotide sequence ID" value="XM_014684594.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V097"/>
    <dbReference type="GeneID" id="26247116"/>
    <dbReference type="KEGG" id="mbrn:26247116"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058593">
        <property type="entry name" value="ARB_07466-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26571">
        <property type="entry name" value="VldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028808002" description="ARB-07466-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ARB-07466-like C-terminal" evidence="2">
        <location>
            <begin position="117"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="245" mass="26142" checksum="275B493B1191E7C5" modified="2021-02-10" version="1">MRHHVVTLLCLAATTALAAPNEPCYADGQAGVCTTEAACAAANGTTATGACPADGADIKCCSKARCGPDCASNCRWQSDCAGSSTANLCPGPAQMQCCSSRDSGFGGYAAPATPPVGDCKPSSVEGAKKIVAAFPGRVWDVGCKRDCECPGTSDHCCGLASDMMCSDGFGVPTLSGKQIAEWVMHNRKDLKLKYVIWGQKIWNPTVDAEPNRWEHWRTMNDRGDVTQNHWDHVHVSYEEFEYQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V106</accession>
    <name>A0A7D5V106_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g086510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542463.1">
        <property type="nucleotide sequence ID" value="XM_014686977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V106"/>
    <dbReference type="GeneID" id="26244977"/>
    <dbReference type="KEGG" id="mbrn:26244977"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="324"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI72336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="829" mass="92603" checksum="8BD47F0C9C76EA71" modified="2021-02-10" version="1">MGDQQKDIARSTSIPASSSSTVVGGPTGDGEAKATQRVKRSRRVKCDEGKPECYRCVSTRRSCQGYQELSSRASKNNTQGARRRARRGAGPSRPRGDQDGLSSSTTNASTVEAPFSFDRSLSASSSMNQGLERESSSETHSTDQNLSDLLGGLKVNEQGVAPYLRRKPVGDEPSAADDDEAGDSTDDEDDESEYLNLVLPMTKLPGHKLQIPPALMPADSTAQRYFKLYFDNVHPYVPVLDEVAFYRQWNARRASISPLILEVVFAIGSRLGEDSPRVSNQWLALASKHADDFMDVPRLSTLQALLILIKAREVAPKRGYFYRSWMMISQCVRMGKDLGLDEHYENHQAGESGMCDLSPAECQLHTRLWQVIFVVEAMIGNPQGRHDLCVNVESVNFDEPSPNSARSRIGDDYQSEYTVSRAFTYLARLVRNVRNLNGIYLRLRKGKDWGTQPEYLAFEPSMTSFLSSLPADLLVEYPGDNTSPPWLPSAFLGNLHSYYHLSIILFHRGVLGFLDPVVNKTLWKRHIMTCYDSARYLCRLQEAVRKQFGMVGLQSMQRGYSFTVYSGLSCIVLHLVAIVSPDPDLNTGAREYFERCMRLMEEVMHAWWMSDLQKQIDAFREAFSADLSKPFVLRPDFPNIRPRRSPSDQPDQPFPKIKPEPVDSVSYPYVQAATGQQAESPLLDMPQHDLATSASTHLEPQNLQIQSSPTHSNWNTDRLFQTWNTLFGPPPQLEPFPGAAVPPQTPLPAMDNYTFANVSSGPANGFPLPEMQAMGPSSQLPHFENPPQVGLQPEATQQYAATPMPGLFSPSMWQNLAAAMYEDGQKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V182</accession>
    <name>A0A7D5V182_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA repair protein rad16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rad16</name>
        <name evidence="12" type="ORF">G6M90_00g090810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541739.1">
        <property type="nucleotide sequence ID" value="XM_014686253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V182"/>
    <dbReference type="GeneID" id="26245602"/>
    <dbReference type="KEGG" id="mbrn:26245602"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="709"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="491"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="942" mass="105379" checksum="E38627298ADE729C" modified="2021-02-10" version="1">MSANNAPQPVKLSLPLEYQQHLFQELRAEDELVVLARGLGLMRLVTNLLHSYDAAGNNLIVIVGAEERENGWIGEALAEHAAISAAPKARGLTVVNTDFQSVGAREKMYAGGGIFSITSRILVVDLLTGLLDPESITGLVVLHADRVVATSLEAFILRVYRQKNKIGFLKAFSDNPDPFSTGFSPLSTMMRNLFLKRASLWPRFHVTVAQSLEGKKKAEVIELEVPMTDSMTHIQNAIMECVEVSIHELKKGNSGLEMDDWNLDSALLKSFDVMVRRQLDPNWHRVSWKTRQIVNDLTVLRGLLTSVLAYDAVSFLQHLDTIHAAHSPPPGSSRQNQSPWLFLDAAQTIFDTARRRVYSASAKSISQSGDNIDSLRPVLEELPKWALLAEVLEEIDRDLYFEPPARDDSNGTILIMCSNTDTCRQLRDYLQTMHVKPRVATPTTTAEDEEDAHKPSAAFMMRRRLRSYLTWKRQFAQVSATLFSENQKALNGAADSRPGHAGMGRGKPPSNKRRRVRGGGNAGVSAGRTDTGVIAQYFEKPGEVAHLMAEVQITEEEAQQKDDIIADPLDNMEDYYQLYEMQDLVVVHAYDGDQDEHVLEEVKPRYIIMYEPDASFIRRVEVYRSSHNDRNVRVYFMYYGGSVEEQRYLASVRREKDSFTKLIKERASMSLVMTVDPHGIEDPQEAFLRTVNTRIAGGGRLAATAQPPRVVVDVREFRSSLPSLLHGRSIVIVPCMLTVGDYILSPNICVERKSISDLISSFKDGRLYTQAETMFQHYKSPMLLIEFDQNKSFTLEPFADLSGSLSSVAPTNVSSDLQSKLVLLTLAFPKLRIIWSSSPYQTAEIFESLKAQEDEPDPIAAVQAGLDKDMKAEDQAFNQEPQEMLTKVPGVTPKNIKTLVLETENIKEVANMSVGDLEPMVGKVAGKAIHGFFNRNVMEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1M3</accession>
    <name>A0A7D5V1M3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g103970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541393.1">
        <property type="nucleotide sequence ID" value="XM_014685907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1M3"/>
    <dbReference type="GeneID" id="26245643"/>
    <dbReference type="KEGG" id="mbrn:26245643"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="146" mass="15990" checksum="27B445B2B32F48DA" modified="2021-02-10" version="1">MPICDSRPLKSKQGTNKFAAVTRTVKANDRDHKGLAEGTAVILDQMPRYTGKAGFTDTDPKKVKKNGCGRGNWGTFTDDVMGQDFSFNNARRRSNSSSASHHLNDFKTKFEVIDSEPVFEESVHGPVSEEDDVSKTDSSESGRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V294</accession>
    <name>A0A7D5V294_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Reducing polyketide synthase DEP5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DEP5_2</name>
        <name evidence="6" type="ORF">G6M90_00g093600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540728.2">
        <property type="nucleotide sequence ID" value="XM_014685242.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V294"/>
    <dbReference type="GeneID" id="26246341"/>
    <dbReference type="KEGG" id="mbrn:26246341"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="5">
        <location>
            <begin position="271"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="401" mass="44403" checksum="1A0D4D74FAB91BFD" modified="2021-02-10" version="1">MFTFGHSSGEIGAAHFRGKVFSNINTNGAMIAVGLGAEAAQTYLGGYEGRIVLACHNAPVMIIARTVKTGGKAYHSFHMKPAADIYNDLMHEASSHLKNCPRKSIAAFMVSPVTNTALDSARPLDADYRCANLVSPVKFRQAVQTIGSCPVFKYVDLIVVEIRPLSALKGPVKQMCREHKFDKMSCLPTIKRGGNSASQLFNLAGQLFLNNFSLDYERVTAIEETSPPDKIQIGKGKLLVDLPIYQWNYVKELWAEPRRSKEQRAPQNLRHNVLGSHMPGGSKNEPTWRNRLRQIDLPWLKHHSLGGEAVFPAARYFGMATEAVTQMKETSSSPVEIRGYTLHEVITKAALVIPDDTDGIETLQSAAKRPHRLLPAMTQRATRKAWNQALKDVGFDYGPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2L7</accession>
    <name>A0A7D5V2L7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g080760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539327.1">
        <property type="nucleotide sequence ID" value="XM_014683841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2L7"/>
    <dbReference type="GeneID" id="26247870"/>
    <dbReference type="KEGG" id="mbrn:26247870"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="519"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="658" mass="74200" checksum="4FD093C305A9F4D2" modified="2021-02-10" version="1">MSTLTLTDLGSLLTKVGVYDFQSLCAHFPNAHPQSRPTDIYRLLLTNILANLTGCDATLIYESIQLPNTLPNGDLVLPVPRLRLKGPKPNVHAVELAASFPENQPLFQHPTASGIHLPFFFTPKSLSHLVLPYLFERHEAYGRDLTMGLDSSAPTERRKKIIIEFSSPNIAKEFHAGHLRSTIIGAYIANLYESMGWDVTKVNYLGDWGKQFGLLAVGWERFGSEQLLAQEPLKHLLDVYARINALFKPEEEESNKARAEGRDTSEIESRGLYAQRNAYFRRMETGDTDAIALWQRFRDISIDRYIETYARLSIDFDEYSGESQVKSTTVDAVESSLKGKGVYKEHDGSWIIDFEEYGFKGLGTAVVRGRTGSTTYLLRDVAAILEREVKYNFDKMIYVVSCEQDLYFKRVFRTLELMGRSDLAGRLQHVNFGKVLGMSSRLGNVQLLGDILDQSRDAMHDVMRRNTTKYAQVEDPEAVAESVGISAVMVQDMSGKRINNYPFDITRMTSFEGDTGPYLQYSHARVNSILRKAGLTRQEVAEHCLRHPTSLEEQFSDTPHCVNLLRLIAQYPDVTAAALRNLEPSTILTYLFRLTHQLSSCYDVVQVTGTNEGRDVMLSRAGLYEGARQVLENGMRLLDLTPVDRHVPRNSIGSLAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2N2</accession>
    <name>A0A7D5V2N2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g094290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987592.1">
        <property type="nucleotide sequence ID" value="XM_066131476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2N2"/>
    <dbReference type="GeneID" id="26246406"/>
    <dbReference type="KEGG" id="mbrn:26246406"/>
    <dbReference type="OrthoDB" id="4934472at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="375" mass="41292" checksum="B0002FEE184A5ADE" modified="2021-02-10" version="1">MPAHQYYYQTPGHNIAAGVVLSSMVLIVVGARFWTRLWYRQGIKADDLLIIPATVGSLSAIPATCLVLTVATGILIVYGTAHHAIAHRTEIPAEHAKNPLAVHSDQLTLTSKIEYPISVMLPVILGCTKLSFLLFYKRIFAARSRGAVNMVLVGFMVLIGLWTVAFFFATVFYCKTNFFAIWGSALDLMTFCTKGMLRSLALCISDFITDVFIIVFPIPLIYRLELSPKKKAATAGIFLLGAVTVATSLARMITTIRIVKAGFDPNEDEVFVITTWVYWGMVECSTGILAACLPTLSFFTRSVVFERPWDTLASAFGTRPRSSPARDDSLSERIREEATLPYKAGHGGAVQAHSKPRPSHDTTEEAYEMTNGRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Q2</accession>
    <name>A0A7D5V2Q2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monothiol glutaredoxin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GRX6</name>
        <name evidence="4" type="ORF">G6M90_00g098700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546476.1">
        <property type="nucleotide sequence ID" value="XM_014690990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Q2"/>
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    <dbReference type="KEGG" id="mbrn:26240899"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000093">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="180"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="30945" checksum="34F79E9C1331AF1F" modified="2021-02-10" version="1">MPSPRRLRLLALAAIATVVFFLFYSSGVDPSQDSHTIQDFYHKTMDGMKKGSPPGQAIINTKTGEKAGHIPADKDADGDVDEDDRKITAEMQLRLKQAEQDAKDKANIKGGLKPDIPSEIVGKGNSAEGQPKKDKNAAADKGVSGNADKTTDKTKTKTKEPKEESEAEAELSSILKKAPVVIFSKTYCPFSKTAKGILLDKYHIAPVPFVVELDKHAQGASLQDVLLEKTGRKTVPNILINGVSIGGGDDIVELDKQNKLADKIRMLGNKRVKVSERFAPDEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Y3</accession>
    <name>A0A7D5V2Y3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endosomal protein P24B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EMP24</name>
        <name evidence="12" type="ORF">G6M90_00g100150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546334.1">
        <property type="nucleotide sequence ID" value="XM_014690848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2Y3"/>
    <dbReference type="GeneID" id="26240757"/>
    <dbReference type="KEGG" id="mbrn:26240757"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028866742" evidence="10">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="205" mass="23434" checksum="755CBF964F8A6E7E" modified="2021-02-10" version="1">MHLPWAARSLFAVATVAFQVVSAHNIVLPAHGIECFHESLHRDDKMTVTFQTGDREFGSAGNLDVDFWILNPSGGYEVNERSVSTGDHSFTAHTDGKYTYCFGNQHWGANTKEVSFNVHGVVYVSESEMPSDPIEAEVRKLSDLLAQVKDEQQYIIMRERTHRNTAESTNARVKWWNLFVIGVVLGESLFQVWWLRRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V320</accession>
    <name>A0A7D5V320_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g104760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541467.1">
        <property type="nucleotide sequence ID" value="XM_014685981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V320"/>
    <dbReference type="GeneID" id="26245717"/>
    <dbReference type="KEGG" id="mbrn:26245717"/>
    <dbReference type="OrthoDB" id="5149013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="142" mass="15372" checksum="8E1F72215F02990A" modified="2021-02-10" version="1">MVRITSIALVAFATSALAVPAQPGFDATPEVGREHGLFLRQEPPLAERPVVEPNPEEVKTANAELAVLLQNMLDVMGSINEDIKQGKVQLETKTKLTPEEHKAALEIIQEGIFKSAQTLVEIGKPLIEGKGEDKAEPEPEAK</sequence>
</entry>
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        <name evidence="8" type="primary">nuo-12.3</name>
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
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            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI73454.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Epoxide hydrolase aurD</fullName>
        </submittedName>
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        <name evidence="2" type="primary">aurD</name>
        <name evidence="2" type="ORF">G6M90_00g104860</name>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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            <begin position="111"/>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI73338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Protein esc1</fullName>
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        <name evidence="4" type="ORF">G6M90_00g098650</name>
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        <lineage>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF23">
        <property type="entry name" value="ZF-C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="340"/>
            <end position="391"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="288"/>
        </location>
    </feature>
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        <location>
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            <end position="344"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
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        </location>
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            <end position="109"/>
        </location>
    </feature>
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        <location>
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            <end position="132"/>
        </location>
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        </location>
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            <begin position="438"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="501" mass="54283" checksum="00F896DEA2E5E55D" modified="2021-02-10" version="1">MSAMETQSHQPVAPHKAAGLNNILNNDDRPSTNGPPLQLRDSGFYSTAEASSKHTSAASFSVNGLSPAGSGYQSSLADKTPSPVATNLVPQALVSPSASNMSVASMVSPTSPTSDRRFDRPTSIESQGQNGATLGENLVISGGPRRESVDSRINQGISDMRLGSSPYASNNQSTSSIQNTLHSQRNPRPGLESLSVHRISNGYQPSADRNPGEPKVIKTAPAITGPATSHIARAAEPTKGQAWAFPEEEIQRVGPPAHYDDSRRSSITESIASSQFTTESRLPPGQRRLEDGADYARMSTASNEFPPVHHHTMQHKQLSDLQAEEGSGPPGSQPYSRTPELRVSHKLAERKRRTEMKELFDQLRDLMPQERGSKASKWEILTKAIAEHQRLNDSIRALQNHCANASTENEMLHREVQALRMEAAQLRGEIGSSGNPPQQAPPPPPSQGSQPPPPASYGSDIYANTNRTELPPLRSIHNGPDSMTGVQYDAPRVNGYRQERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3G4</accession>
    <name>A0A7D5V3G4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ppt1</name>
        <name evidence="18" type="ORF">G6M90_00g096330</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546701.1">
        <property type="nucleotide sequence ID" value="XM_014691215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3G4"/>
    <dbReference type="GeneID" id="26241124"/>
    <dbReference type="KEGG" id="mbrn:26241124"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="275"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="475" mass="54435" checksum="BC6B7F95FEB378BA" modified="2021-02-10" version="1">MSQEAVDLKNKGNKSFASGDYPAAVDFYSKAIKLNDKEPTFFTNRAQAYIKTEAYGYAIADAGKALELNPKLIKAYYRRGLARTAILRPKEAIDDFKECVRLDPNNKDARLKLEECKKIVRQLAFFAAIEVGDEPSAAEGLDLDSMVVEPEYDGVRLENEMTQEFIDDMMERFKNGKKIHRKYVYQIIIAVKNIVYDEATMVEMEIPDDVELTVCGDTHGQYFDLMELFRRNGTPNDKHWYLFNGDFVDRGSWSTEIALLLYAFKWLRPNGFFLNRGNHETDDMNRVYGFEGECKAKYNERVFKLFSESFSALPLATLVGEKYLVLHGGLFSDDKVTLDDIRKLNRHNQRQPGQAGLMMEMLWTDPQDEPGRGPSKRGVGMQFGPDITKRFCENNGLEAVIRSHEVRMDGYEVQHDGRCITVFSAPKYCDSTENRGAYINIKSDYKLRYEQFDAVPHPDIKPMAYAQSSLMSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Y7</accession>
    <name>A0A7D5V3Y7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g089090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541573.1">
        <property type="nucleotide sequence ID" value="XM_014686087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Y7"/>
    <dbReference type="GeneID" id="26245436"/>
    <dbReference type="KEGG" id="mbrn:26245436"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="206" mass="22976" checksum="94A4870518FC64CC" modified="2021-02-10" version="1">MSAAKLSADLLIQMAKARRTIYALDKNLPVSTTRIQELVNETTLHTPSSFNSQSNRAVVLLGPEHDKLWDMTASTLRAIVPDDKWKHTEDRMAMFKKAAGTVLFFEDDDVVKGMQAAFPSYADRFPAWATQSAGMQQLLLWTALELEGLGANLQHYNPLIDDKVAATWSLPRSWRLNAQLVFGGRAGEPGDKEFKPLEDRVKVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4T2</accession>
    <name>A0A7D5V4T2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar iron transporter cccA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cccA</name>
        <name evidence="7" type="ORF">G6M90_00g102770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546071.1">
        <property type="nucleotide sequence ID" value="XM_014690585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4T2"/>
    <dbReference type="GeneID" id="26240494"/>
    <dbReference type="KEGG" id="mbrn:26240494"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="28906" checksum="9C8AD95199AF84A5" modified="2021-02-10" version="1">MSKQSPCLTRFLSDFTLGFSDGLTVPFALTAGLSSLGRADTVIYAGLAELCAGSISMGIGGYLSTLDEVPHPTGKKDDLDSNGDEEELRGMLRDGSSRASSSHLSDNLDEKYLEQESKEDLIRSHLEPLALPPATVLEILVILRSRPDGVGGTACRLQQQNAATEPLSDQLPIWPVASGLSISLGYVVGSIIPLFPYFFTSTVGRGLHWSIALCLIALMTFGSSKSWILRGEERSVKRSLWEGLQMLVLGSLAAGAAVLCVNLVGAGSEPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Z2</accession>
    <name>A0A7D5V4Z2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g101150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546230.1">
        <property type="nucleotide sequence ID" value="XM_014690744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Z2"/>
    <dbReference type="GeneID" id="26240653"/>
    <dbReference type="KEGG" id="mbrn:26240653"/>
    <dbReference type="OrthoDB" id="2534759at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="530" mass="59005" checksum="174488CBAB51074C" modified="2021-02-10" version="1">MATVNGHQIHRSVSPETSPTLAIGACPELSRCVSTASSMSHSSATDASPRDSLGGELFSRQSSGSFRSSRLSDVSNISRQSTHSLDSKGRKRGYVRPQATDFAASARSRDSVMCLGSIAHLQYYFARTGLLDGKGGQLARKKPNQRATLDLSVLESTSSTPTILGIDVDSSYDPVDSNPEHASLGMEANVTVGSPAEDADEDYFEDSFAESDPGMLPPTVSTYHQRDDPIPKPPTIDELKAELETSLTDAQKALDEVLDRKAGSFQETPDAPQLPNMPEENTQGWYELQGMHILDVVTLAIRAAKMYYTAHEMPDRLDYIKSEKQIRADLLAVMEVLKQMATRNFKGGLREDEIKTMVGWVESVFHILDKEQEIEAAERAERTSWVWLDGDWTGRVVERERAFLLSLDPEGEALPDWTPLSQASECPTPFLRSLQNGLRLVKLHNAAVKKSRRRFGAIPTFHADTQKPYRCADNLRYWVKAAELRFEVMLKVDVLGVVYNNGPEVWQDFEAAILKWCKHVREEIASELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V577</accession>
    <name>A0A7D5V577_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546214.1">
        <property type="nucleotide sequence ID" value="XM_014690728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V577"/>
    <dbReference type="GeneID" id="26240637"/>
    <dbReference type="KEGG" id="mbrn:26240637"/>
    <dbReference type="OrthoDB" id="5224680at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF49">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="86"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="381" mass="42856" checksum="67A4670BFC647CDE" modified="2021-02-10" version="1">MAPELNGPVIGSRIAPTHDVAFPAPLVEVSGLPNGFPAMLDSPLAWSGRQFKRDSDYVFRLEEPHLIEIDQALQEFKKLGLDGDLVSTQNFALPTLGLKLLDLQRDIYCGKGFGLVRGLDPQRYSVEDLTTIYMGIQCYIANLQGRQDKKGNMLVHIIADNSTKMKALHHRHSTAPITFHNEEAGDIISWLTRSTAVSGGKCILASVYTVYNALAASRPDLVRVLARSDWPFALPRFQCRPVLFYHDRRIISNFGRAALLGSASHVRPDRLPKLNSIQIEALDAIERIAQATQLEITTQAGDIHFINNLAVLHRREGFTNGSSTIEKRHLVRMRLRDSEMGWSIPNELKDEWVETFDPKLNRVWHLESMPDGFFPLRSQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5E3</accession>
    <name>A0A7D5V5E3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Damage response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DAP1</name>
        <name evidence="8" type="ORF">G6M90_00g110410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543818.1">
        <property type="nucleotide sequence ID" value="XM_014688332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5E3"/>
    <dbReference type="GeneID" id="26243205"/>
    <dbReference type="KEGG" id="mbrn:26243205"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="179" mass="19316" checksum="8C57F88069474022" modified="2021-02-10" version="1">MDYVGHRVVQEAAKEAASTTTPFTPLNLILLSVLVYTAVSTFSRSNTTAPIPRGPPPKVFRTYTPRTLLPFNGENGNPIFFAVRGRVFDVSNGRNFYGPGGPYSNFAGRDASRGLACHSFDTEMLTEDLDGPLDKLDGLGPSEMDALQGWEETFSGKYDIVGKLVSVADYNAGKAEGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V665</accession>
    <name>A0A7D5V665_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 monooygenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">P450-1</name>
        <name evidence="12" type="ORF">G6M90_00g112050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540277.2">
        <property type="nucleotide sequence ID" value="XM_014684791.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V665"/>
    <dbReference type="GeneID" id="26246871"/>
    <dbReference type="KEGG" id="mbrn:26246871"/>
    <dbReference type="OrthoDB" id="4945151at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12811">
        <property type="entry name" value="MALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054550">
        <property type="entry name" value="Mala_s_1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22701">
        <property type="entry name" value="Mala_s_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028944799" evidence="11">
        <location>
            <begin position="23"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="811" mass="89318" checksum="D82186DDC1433878" modified="2021-02-10" version="1">MLRAAVTLFSASLGAITATAQATTGGDPASLGAITATAQATTGGDSASLEDITPPAQATTGGDFNITGAQLYPEKCVFDSKRDVMYCSELYESKIAVVDLKTKTIVKTIDFPGLSGDADYHASGVLIQGKDRLISSINTGAAFETSGGNITGTNYLLITDLETGEEKARVNVTDVTNGTYGGPQDFATDTCGNIYQVFTYPGAIIKVTPSLKVIPWYLSKETNSTKAGFTGIASRGNMLLTSNEQQGGKIIRFDAHNKTGDPFEVPIANNGMLGRFLDGILLPAKYNGTVLLVTSSQNGTTVVESKDGEWNSAEILGIVPNPYWENEQGFSTQTFDREDRIYQMFEWFLDSRAPANLNGLSGNRTVFPFQDITDAVDKLPIRLIGDVKEVTVLPPSLAQEIRNDKRLSFNQWTFKAFHGHLPGFEAFAAGTGGSNLVQTVVTKDLTKFLNKITEPLAEETAMALEELLTNKTEWHTIAMRDVVLQLVARISSRVFLGTELCRNETWLRVTRDYTVTGFLAGEELRLWPEFTRPLVHWFLPSCRKLRREVNEARCAIQSTLARRQQLKQDLVAAGKDVPEYDDAIEWFEKAAKGAPCDMTALQLSLSLAAIHTTTDLLTQVLTRISQNLDILGPLREEITSVLADEGWSKTSLHKMKLLDSVIKESQRMKPGEIVSMMRLAVEDVQLSDGTFIPKNTGVAVSSHRMWDPDLHHDPNHWDGFRFYKMRDDPGKQNVSQLVFASPDYLAFGYGQNACPGRFFASNEIKIALAQIITKYDFELQEGSVPQIHKHGFGLRGDPLLKLRVRRLAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6B0</accession>
    <name>A0A7D5V6B0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g111370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543727.1">
        <property type="nucleotide sequence ID" value="XM_014688241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6B0"/>
    <dbReference type="GeneID" id="26243114"/>
    <dbReference type="KEGG" id="mbrn:26243114"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="232" mass="26373" checksum="D82E8E8C12E0E7AE" modified="2021-02-10" version="1">MKNILTSLFSPRKTSEDREAAPSPLGPKSALSSNKSRRRSLPEQKMERSVRFQHILNDTDISPISTKSPSEKSKSPEKKTSPGAGSRAESPRRPGNALDQGAQDGEYAFNRFVDYRWNGDSVEVQVEWEAGDTTWEREDQLHQDAPDALLEYWESQGGRPVNPNNADLFDIHAIRKHSKDRKKLLVEWVGYGPKEATWVPRAVVEETAPEVVAQYWKTVQPGRPGRRRRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLP3</accession>
    <name>A0A7D5YLP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g010270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985829.1">
        <property type="nucleotide sequence ID" value="XM_066129685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLP3"/>
    <dbReference type="GeneID" id="90967445"/>
    <dbReference type="KEGG" id="mbrn:90967445"/>
    <dbReference type="OrthoDB" id="10357115at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="137" mass="14783" checksum="994E87985ACF0732" modified="2021-02-10" version="1">MPAAVPDEEPGCPTDRPSKDGNSLFSQKALHIQKQCQKDLFRDDSMIKDIDQAGKDAICVEFGREGVKCRDDIGCLDQVGKVANKCLKSTQKSAKQPAGKGSGNGSDAELLKSANNYMDVQNNGEGPECRDHVRKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMY6</accession>
    <name>A0A7D5YMY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">tif-1</name>
        <name evidence="21" type="ORF">G6M90_00g012390</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549283.1">
        <property type="nucleotide sequence ID" value="XM_014693797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMY6"/>
    <dbReference type="GeneID" id="26238727"/>
    <dbReference type="KEGG" id="mbrn:26238727"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="397" mass="44819" checksum="894DE99DA83718F2" modified="2021-02-10" version="1">MATDKGLEDVPEGQIESNYDETVDSFDDMSLKAELLRGVYAYGFERPSAIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISVLQKIDPTVKQCQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTSVREDMKALQDGPQVVVGTPGRVHDMIQRRFLKTDAMKMFVLDEADEMLSRGFTDQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTRFMRDPVRILVKKDELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTEKLTARDFTVSAMHGDMDQAQRDLIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTAEDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPQ7</accession>
    <name>A0A7D5YPQ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">crp-7</name>
        <name evidence="4" type="ORF">G6M90_00g026010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547980.2">
        <property type="nucleotide sequence ID" value="XM_014692494.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPQ7"/>
    <dbReference type="GeneID" id="26237424"/>
    <dbReference type="KEGG" id="mbrn:26237424"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="210" mass="23499" checksum="848EF13AE4AB6A51" modified="2021-02-10" version="1">MGLRAQSASQDPAEQQNVVGRLCDRYDVRKALLPASGDPATRKLEVDTEPKILASDEGQDSTKAPRYQVTYHMTHRKPSPLHEIIEQCQICLANSKRFFGDHIDVGQLLNSTPRHPRHHTTDKMENDRGEIVDLYVPRKCSATNRIIKAKDHGSVQISIAKVDENGRAISGESHVYALCGFVRAMGESDDSMNRLAQRDGLLKNVWSAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQC9</accession>
    <name>A0A7D5YQC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rad9_0</name>
        <name evidence="4" type="ORF">G6M90_00g022330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548322.1">
        <property type="nucleotide sequence ID" value="XM_014692836.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26237766"/>
    <dbReference type="KEGG" id="mbrn:26237766"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000494">
        <property type="entry name" value="Sister chromatid cohesion protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="3">
        <location>
            <begin position="1431"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1776"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1806"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1841"/>
            <end position="1852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1852" mass="203944" checksum="55EE2C636FA5668F" modified="2021-02-10" version="1">MAHYNTNGPKNGVKSVEGPREQNGVSRPFTLQESLPYSPQTSTVPFLPDIIPDPSVGSGSPSLRISDLFSTQDYDRVNQEATSQPHGAKNLKQTVDHVLHDLKPSKRTQYKFPTVPNGAPSSSAASTHNRIISQGLSPIAKAVYERVGSFFKATKPNISSPKLVNGEAEQPLKLAADSVSQSPTIHVQPQSTAKNNAGSGKTKIEVAISTKQSFDRSQYAEISYDHPDQNIITPHDQLIVEAQQYSQSNPLTAKSSIVVNNAGLLIELPTSGIKREDYQEFKVAPDAPENLSFRRKERQEFEDGQDIIGASLDQRQRGEAALDSLDALMRQVFSAVGGALVMEPGLEHIVTLTADQEASMTATTQQKMHTAIQKVIGLRSFNAVPLENLLRVMKLSEASLKQAEGLDIRVDESWDEAAVESWVQQLGELQTALKSARTCLRIMSGCREDKQLYSEAVITKCVNIYKAVTEDIVMPLVELRNSGSSGGLFKLIQKHKKTIASVFVCCQKLSALLAELITKIELSETVINTLEFTSSKLIFVENAYLEKDSAIGLQKFDGIRSVAMDMLCQIFLIKPEQRQGIIDDILTSLEKLPVGKLSSRQFKLADGGSIQPVSALIMRLVQASSGRVGGGNGAGQGSNIRAMDIDGLGEDDEDDRPLKRNQATATILNEEQGAQQPAVAIQELEGVAAPLIDTAARNASYVINFIVKRAMGSTKSGDTPYRNLLDLFVDDFTTCLDLPDWPSAELLLRLLMVMMVQLFEAPKTAAPAKNMALELLGTMSAAISRLRSHVKKSAGAFISSDAGKYSKYLSDLATHCLEQRCPMENIIAWAGPYRGVLEYLQERSSEDPHLSSAVSFLISDWATRVHTTYDNIQDNDSEGDKELGRSAFRLRMMIEDRQWLASEYTFKAVTTSQARFAFSVILLRSPFCESFGKILNILLGSMASDQATVRSKSLKSVNQVLETDPSILDGDSTVIQLILDCASDSSTQVRDSALGLLGSCISMRPVLEASLTPKIIDRFQDAGVGVRKRAMKLARDIYLRNRGKNLRSAIANGLLRRIQDPDEGVRDLARQMIEEVWFAPFYTNENTASFETSLAEHVSLVIQTVKGGTVTEILDKVLQTILKPGSKSLDGPFGVCSKLVGIMFGLIDNPESEDPTVPSGRDALQVLTIFAKADPNLFNFEQIKLLKTQLASFTGADELAAFRAVTVIYKRVLPQLPNVHTEFLADVRLQLLKGIGKISSRGALDDLIACAHTVCELLKDFAPLGNLVASSLVGIQKLSKVPLDAKRLNLVAAYSIIVGSVGKHCDLDKQARIFREKFPGWKGDSVSKLIVDILSPFSSPQQPLDARKASIEAIGLVCQSWPRNYDLVKVYTAFQQVFQDKIPILETMILRSFKEFLVTEERRSEAAAEAPKEKNKELTVMGGTNFDDVASGATQRFLKEITRIALSSQDEHAFLAMEVLGSINRQGLTHPKETGVTLITLETSANRKIAELAYLEHRSLHEKHETVLEREYVKAVQSAYNYQRDIVKDSHGATMEPFQSKLHLLMEVLKISKMKNRQRFLEKFVGQADFELGKLNVKAEMPHQVDFARFIAENLAFFEYHSIGELQTTVNMIEKMVASTGASVAQAIESEVFNVRMDVDQEEEQRKTLLEGDVPVGVPVGGTQPDVPPPAVPVPTLSVEPQRLRQLTAGSIILLSLWEVRTHLRRLFGMGTNRHDNRAKALAKDLNKTPLKVQGVHGERVWDEIVSHMNGLSSQESMVQKCKAFVELMNVDKEFKVAEEDDEMGMGGGPSTPSEGEDDDDGGDRGRKRKAAGTPGGRKKRARSGSQTRKRGRPRKQSVEQSDDGDFDGDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQG2</accession>
    <name>A0A7D5YQG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rnr-1</name>
        <name evidence="15" type="ORF">G6M90_00g048600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544975.1">
        <property type="nucleotide sequence ID" value="XM_014689489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQG2"/>
    <dbReference type="GeneID" id="26242316"/>
    <dbReference type="KEGG" id="mbrn:26242316"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="804"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI68220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="905" mass="101213" checksum="3F7E85BBB0C80177" modified="2021-02-10" version="1">MFVRKRDGRQERVQFDKITARVSRLCYGLDTEHVDPVAITQKVISGVYGGVTTVQLDDLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQWSSVVSDLYHYVNPKNERASPMISKDTYECVMRHKDELDSAIVYDRDFNYQYFGFKTLERSYLLKLNGKIVERPQHMIMRVAVGIWGDNIERVIETYNLMSSKFFTHASPTLFNAGTPQAQLSSCFLVDMKDDSIDGIYDTLKTCAMISKMAGGIGLNVHRIRATGSYIAGTNGTSNGIIPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADVFEFLDLRKNHGKEEVRARDLFLALWIPDLFMKRVEKNGDWTLMCPNECPGLADCYGEEFEALYEKYEREGKGRRTIRAQKLWYSILEAQTETGNPFMLYKDACNKKSNQKNLGTIRSSNLCTEIVEYSAPDEVAVCNLASLALPAFVDYDEGRYDFKKLHEVTQVVVRNLNKIIDVNYYPVQEARNSNMRHRPIGVGVQGLADAFLALRMPFESPEARELNKQIFETIYHAALTASMELAKEQGPYSTFKGSPASEGILQFDMWNVTPSDLWEWDTLKQQIKEHGIRNSLLLAPMPTASTSQILGNNECFEPYTSNIYQRRVLAGEFQVVNPWLLKDLVDMGLWSDAMKNRIIAENGSIQNIPNIPADIKALYKTVWEISQRQVVQMAADRGAFIDQSQSLNIHMKDPSMGKITSMHFAGWKLGLKTGMYYLRTQAAAAPIQFTVDQEALKVADASVGKDRLPKKRTAPAGTSYMTSVSAVPRAAHLRKEDDINAVNANGIPTPSNTPPPAGASRPIASPSKPAAIKADVDEGDSPKVLPTEPSEVIKDEELAEPGTKRSGQSEDGDDSGERERDIYSEAVLACSIENPEACVMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRI9</accession>
    <name>A0A7D5YRI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Transfer RNA methyltransferase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">TRM8</name>
        <name evidence="12" type="ORF">G6M90_00g036890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with TRM82.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986248.1">
        <property type="nucleotide sequence ID" value="XM_066130192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRI9"/>
    <dbReference type="GeneID" id="90967625"/>
    <dbReference type="KEGG" id="mbrn:90967625"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="257" mass="29169" checksum="B3C9BA76D82D73DB" modified="2021-02-10" version="1">MPRIKLVSRDSHGNDFIDSVLMPTPSQITPLNSIPSSPEAMDWSSYYPAYVADTPPVESTHPQKLTKDVEVVDIGCGFGGLLVALAPLLPESLLLGLEIRTSVTQFVQEKIWALREQNEGKLYQNAACIRANTMKFLPNFFKKGQLSKIFICFPDPHFKARKHKARIVSTTLNSEYAYALRPGGIVYTITDVEALHHWMVQHLDAHPSFERVSEEEEEKDECVKVMQNETEEGKKVARNKGQKFVALFRRIEDPPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS40</accession>
    <name>A0A7D5YS40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g029920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986356.1">
        <property type="nucleotide sequence ID" value="XM_066130049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS40"/>
    <dbReference type="GeneID" id="26247464"/>
    <dbReference type="KEGG" id="mbrn:26247464"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="115"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="376" mass="40716" checksum="4D35502046F52061" modified="2021-02-10" version="1">MKPVRLVMAFTQASAMALSTGGRAASPQDGTRALLDVTLDQDSVAEHGVYNGTGCAMSPEQELELQKRASETQSCYGLQDELDAALEECVKLSNLAAEAASGAAKGLKSRDGNEQKKAATLDNFFGISNSDEVADNFRRIARGCSKDKAKGISITCAPREECTLQNRPRQQYAATATIRNGTTGSIRLCRKAFQMPATAGNARRRLQVQGQQECGQSLSSLAQLFVHEMAHTTFAADDLTYDKRKSLNLDENKQKHNADNYALFARDIANDYPMDLEILAANRALRKDPRVLVTVLQIVLLPEATVSPRGHSQALLYGQSGDSSDDPDCDFDDPPPFTGSESEVAFQPPSQFQPPNFSPPPQGNDLLLGMGLSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS62</accession>
    <name>A0A7D5YS62_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g046620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986396.1">
        <property type="nucleotide sequence ID" value="XM_066130414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS62"/>
    <dbReference type="GeneID" id="26242129"/>
    <dbReference type="KEGG" id="mbrn:26242129"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="304"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="727" mass="80928" checksum="E60F963E5373E86A" modified="2021-02-10" version="1">MLHEILLSLSGHPSPLLHTPPSPEADALAGITPPERQLLSSARHISDLNTNLIAYSTEISTTHSSTICRAVATAISSVHLAAFQRKVLQVEESILRNDADWVGAYNIVPLTAIMGEFQQWTRRLEWLWDTVQFILAKNTDGSSCRGSTLIDRLRDELQSGYQDVAATAESLVKVAETAWLKQVSAWVLYGRLPSFGADDFFVQKLHGSPEDYVCVENCLPSFVTGATAASMIFIGKSLNHVRAMNNTSSSSGGVAHVSAKLQELSTLTLPLENTEFSKAVKAIRTSLSQNTLQKMLPLARVSEMIQLLRDFFLLGRGEFAMALTHEADERVRNRWRRAGNLAYEKDDGLKNITVKDGEVAAVLNRTWAVLVSMQGQHAEEDDQLELARSLIQLHLTKSKPPAALVTGRGLDVQAANVLAASPFRNMLFSVPAMLSLDLPSPLDMVISPSDLQLYSSINAYLLSLRRAHMRLTGLWKITSLRRHYPAPRGASDDAVTLRERWSDRSWLLRSTWTTASATIFFLAETEAYFQTEIVKTLWDDFHAWLIPSQPQRSGHATPIDHHHSQPPSQHSHDPQTLATAHTLYLRTLTHRLLLTQASFTDQLYALLQHIDHLVTHIHRLHSLFTSLDLEHDAGVVDAFVDLEREQSQVFSSLHNIQLKVKQGINDVVSTLRDLESDATFLAEWDGQGLVDDEGEDRGYVPCRVGGVDRLLMKLDFGSWLGGTAWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSE3</accession>
    <name>A0A7D5YSE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">YTM1</name>
        <name evidence="10" type="ORF">G6M90_00g004380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542088.1">
        <property type="nucleotide sequence ID" value="XM_014686602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSE3"/>
    <dbReference type="GeneID" id="26245119"/>
    <dbReference type="KEGG" id="mbrn:26245119"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="159"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="208"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="367"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="473" mass="50688" checksum="42519463718B042E" modified="2021-02-10" version="1">MDSSPTQVKVIFTTDEQDLQLPESKRQLLVPADVKRYGLSRILNSESMLDTSSPIPLDFLANGTFLRTSIEDYLKSNGLSSETTLTLQYVRSLIPPVYQASFQHDDWVGDVDVLSATAPASKGIDGVVNDRIASASYDGLVRVWNPSGEAIATSSAGRAGGHTSRVNAVRWLSPSKLASAGLDRKVVIWDYSESEDNFSGSLKHNMELWGHEKNINAIDVNCATKRILTASSDGRVGLWTSSKKAAPQADAESLPSSHSAKRAKLSAASNTAQRGPLAMMPMHDDQVTAAIFHPHDSTVAYSASQDHTVKTIDLTTQKEVSRLTTLHPIMCAAALPGNSLVAAGSSARHITLLDPREAATATAAMTLRGHINMVVSLSPSPDNEYSLVSGSHDSTCRVWDLRSVRPATSEEGSGSVSEPVYTISREWLSGKKLPPAGDGAKVLSVAWDKSWGIVSAGEDKKVQINRGRGLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSL9</accession>
    <name>A0A7D5YSL9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpl-7</name>
        <name evidence="7" type="ORF">G6M90_00g035410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546936.1">
        <property type="nucleotide sequence ID" value="XM_014691450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSL9"/>
    <dbReference type="GeneID" id="26239499"/>
    <dbReference type="KEGG" id="mbrn:26239499"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="6">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="5">
        <location>
            <begin position="90"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="249" mass="28556" checksum="9CA47369AADAB8B1" modified="2021-02-10" version="1">MGATTVPTKEQILVPETLLKKRKSQEKARAERTASLQKKKAANKEKRGVIFKRAEKYVKEYRDAEREKVRLHRVAKENDSAYVPAEAKLIFVVRIKGINKMPPKPRKTLQLLRLLQINNGVFIKATKATTEMLKIVEPWVAYGYPNLKTIKELVYKRGYGKVDKQRIALTDNAIIEESLGKYGIVCMEDLIHEIYSVGPNFKQASNFLWPFKLSNPTGGFRPRKFKHFIEGGDLGNREEAINALVRQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUA2</accession>
    <name>A0A7D5YUA2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g010670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549452.1">
        <property type="nucleotide sequence ID" value="XM_014693966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUA2"/>
    <dbReference type="GeneID" id="26238896"/>
    <dbReference type="KEGG" id="mbrn:26238896"/>
    <dbReference type="OrthoDB" id="4837859at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="123" mass="12787" checksum="8F723B21A36290BA" modified="2021-02-10" version="1">MGSSQSAATSSDAGQEAKKSTSLYRKYQDKKGARPISDDDILKYTGKTRDELKSWADGQPGVGKNQLAGKLAVGSASGLGGVATGAGYGGWGPSAEPQGANRGMKFPPEHRESQPKVVDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUN0</accession>
    <name>A0A7D5YUN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Ap1b1_0</name>
        <name evidence="8" type="ORF">G6M90_00g023150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548240.1">
        <property type="nucleotide sequence ID" value="XM_014692754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUN0"/>
    <dbReference type="GeneID" id="26237684"/>
    <dbReference type="KEGG" id="mbrn:26237684"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="712" mass="79556" checksum="3BD83F026D5A4E5A" modified="2021-02-10" version="1">MSSKDSGGDSKLFARGKVAELRLELNSGGKKDKNYAIKKVALKRIVANMTMSNNDMVALFPDIIACMHIPSLEIKKMCFLYLVNYARVRPEIAVKAIPVLENDMEDQNPLVRALALRTMSYIHVKEFVEATVPIVKHMLRDNDPYVRKTAAFCVAKLYDHDRQMVERSDLIDRLNSLLRDDNPTVVASALAGLMDIWERSDAIKLTIDYSNASKMVAILPDCSEWGQTYILEALMSYVPQETGEAALLAERIAPRLSHSNSSVVLTCIRVILYLLNYIADQKQITTLCRKLSPPLVTLLAKGPEVQYLALRNALLILQRRPEVLKNDIRVFFCKYNDPIYVKVTKLELIFMLANENNIDEVLTELREYATEIDVHFVRKAVRAIGKLAIKIEPAAKRCIDLLLELVSTKVTYIVQEATVVIKNIFRKYPNQYESIIGTLCEHLDSLDEPEAKAAMVWVIGQYADRIENSDALLEDFLYTFSEEPVEVQLALLTATVKLFIQRPTRAQELVPRVLKWATEETDNPDLRDRAYMYWRLLSTDMNAAKQIVMGDKPPITAEAERLEAPTLEEMCLNVGTLATIYLKPVQTVFRSARPRKLQESPALQKQNLLVDADNQKSISMFGRGGQPTNIDLRSRNAAPANGEGNLSQAVSDADAYFSSIGTQMAAMTLDQGEDMFGGGSGNMTGYVVSAHAPQAVLQPAQGAGSNGDLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV02</accession>
    <name>A0A7D5YV02_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose-phosphate pyrophosphokinase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">KPR5</name>
        <name evidence="5" type="ORF">G6M90_00g072080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545854.1">
        <property type="nucleotide sequence ID" value="XM_014690368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV02"/>
    <dbReference type="GeneID" id="26241887"/>
    <dbReference type="KEGG" id="mbrn:26241887"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="433" mass="47339" checksum="23CE6B9723EF0CED" modified="2021-02-10" version="1">MVRNIVLLGGNSHPRLTENVSNMLGIPSCDRILSKFSGGESRCEIKDSVRGKDVYIIQSGSGHVNDNLIDLCIMISACKTGSAKRVTAVVPLFPYSRQPDWPYNKAGAPLSKSTETSKKDYTFESVPATPRPGGPRSHGLNGAFSLSEKLQKTTIAETDDTDYLPKRSDTLSSIGSNGRGHTAENSTSSQRSFTTHDYENPNSVAATFQAKPGYKQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGKPLIQNYIQKHIPGYREAVIVSPDAGGAKRATAIADSLKMDFALIHKERRPIKFTEQRNASMMLVGDIANRVCILVDDLGDTANTITRAAKLLKKEGATKVYALLTHGVFSGDAIPRLNASAIDKIIVTNSVPQDEHRRLCPKLEVLDVSPIFAEAIRRVHHGESISRLFQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVA8</accession>
    <name>A0A7D5YVA8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyol transporter 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLT5_1</name>
        <name evidence="11" type="ORF">G6M90_00g050820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545183.1">
        <property type="nucleotide sequence ID" value="XM_014689697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVA8"/>
    <dbReference type="GeneID" id="26242524"/>
    <dbReference type="KEGG" id="mbrn:26242524"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="117"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="636" mass="71090" checksum="035A08B163A5923D" modified="2021-02-10" version="1">MASDAPEKAVVVDESADHAVGKEGSHRRRVSLVANVEGEIENPLRDISRAELLEKVNRFHKDKELPEDILPLLRKGALVAQNPADFEAIEDLDESDKIALREETTHRWKQPWPLYYTIILNSIAAAIQGWDQTGSNGANLSFPQALGIPDSAGSSCGPVANEGECAKNSWIVGFVNAMPYITICLFAGWISDPLNDLLGRRGVIFIAAIFSLLAPFGMGLSQTWGELAVCRMLLGIGMGLKEVTVPVFSAENSPAIIRGGLVMSWQMWTAFGIFLGTCANLAVGKTGDIAWRLQFASAFIPAVPLVIGVFFCPESPRWCLKKKRYNQAWKSLLRLRNTPMQAARDLFYINCLLEQEVELVKESGLKVTSNVFTRFVELFTIPRIRRATWASGIVMIAQQMCGINIIAFYSSTIFKQSGIDDYTALWASFGFGLINFLFAWPAVWTIDTFGRRALLLFTFPNMFWALLVAGLCYLIDKGVENSTARIASVATFVYLFAAFYSPGEGPVPFMYSAEVFPLSHREVGMSWAVATNNFWASVLSLTFPRMLSAMTPTGAFGFYAGLNLVALVFIFLFVPETKQKTLEELDYVFAVPDRTHAKYQLGTVLPWWFRRWFLWRRNETCPPLYHEAKQRTTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVG1</accession>
    <name>A0A7D5YVG1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">THO complex subunit mft1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mft1</name>
        <name evidence="5" type="ORF">G6M90_00g101520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546194.1">
        <property type="nucleotide sequence ID" value="XM_014690708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVG1"/>
    <dbReference type="GeneID" id="26240617"/>
    <dbReference type="KEGG" id="mbrn:26240617"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="107"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="346" mass="38641" checksum="A9B7334237AF3FAA" modified="2021-02-10" version="1">MASWALLDEKSESELHKSRLLNVEEKPFKRITKRLSTISSVVSVATQHNGTTENGADAANLPSLKEDLTLDFAAFDSSIARLQFLHDANQRERERYAADQQRILTECQAVRANNGQLREQLNSARATLDQRKKFDELAEKITSNRLLRPREDQLANLAKLEEECRELERESGTYKGTWKERREQFNRIMDEGRMLRRQIRDEKEEVDRREGMNEEGEDDADGEREGTTPRPVISGNATPHPDGEGQSKGENDVENEDESANAAASSRDRTPSGDTPAQDRAGSRAAPTPAESTSSAPRGSGKYLQVPGSATPSHQGAGDVDMEDQVETQRTEQENGEGEDEMEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVS3</accession>
    <name>A0A7D5YVS3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g026820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547904.1">
        <property type="nucleotide sequence ID" value="XM_014692418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVS3"/>
    <dbReference type="GeneID" id="26237348"/>
    <dbReference type="KEGG" id="mbrn:26237348"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="385" mass="42658" checksum="617F0F3F041C10A4" modified="2021-02-10" version="1">MSLCFTEIKPSRPPSNELTSATGSLVYILNVVDPAYSILSFGERLKDIPKRMEHNKVLTAASKALTASVFSFYTGSVSSKPLVHYGEALRVLISSVGAVHCKTQIVDTMCAIGILLASHNVRGSNRREFEVLLRGLVYFLDMLGDEELENAFDNEVVSNLRRLVIVASIMDPTMRFNPRLHDGKKRQSGLVATAPGNVGTARCSQQWRDLIQISSYLEDPTSNLDHITTTYQRLSTDLALLEKNATDVFGKVKTSRDSLLSLQYIRQEAGNSGLLTMAMALNMTLRIIDPGNSALLEEAVTFVSVVLRAADRVSLFKPLSTALLGNSLCLAWVVAVNPQEKERVRKMLDEHSYIFRGTTWECLATKFQKRFDGIRAQVRSPKTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW01</accession>
    <name>A0A7D5YW01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Utp8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g041440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547489.1">
        <property type="nucleotide sequence ID" value="XM_014692003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW01"/>
    <dbReference type="GeneID" id="26240052"/>
    <dbReference type="KEGG" id="mbrn:26240052"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="1">
        <location>
            <begin position="8"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="906" mass="99509" checksum="E73C5B730D270361" modified="2021-02-10" version="1">MASEHKIHRPYVLATLPRPLDHTGGRIVAREVYGLRPGQKKKKRMELAVGVDGETASIYDVPASRLITSYPIPPQESFTCAPYSIRLRRSGSEDVYRYTYIATRDAKSYKVTLFRDVVHPDGKTTTSTTSQTLRASPIHITGSSSTTSSLSGNTVGDVVAICEDGQVIYLTGEDLTLQWSSPFKPAIQDVIAGAIESLRVEYVSSGSVTDFREGVFKSRLEIFSALPRALDVDPSLIFVVVKSASEGKSTRHLLVLATLPGGAAAAPGVQNLIPLDISPLPANSSREESPVYEVDIHSGFLTELANDVLSVYDITSAVPKKKSMIQMAGTQSFIRLSRPFLLTTSTDSMVLYNHQYSSVHGRADLDLSELPAEDQQARNCQLITYFRSQDLAIALIDNVLVSIHVEPPHYHGKRRKEGLLIDSIGRGAPFEVQTKPSKGESVSAEFSRLIPGSMTEEYLVAYHKEILAANEMLANNALGKWEDLLRQKFGLKNQNDPALANGEATVEAQELPEWDWQTETGSYPPVDRRWVIYAISQVFSVETTSSDEPKPELRLALPDSNVTTYLVVAGHLTISNLISAFRDVLPLEASGIKAVARDLIHSLTDADPSMTLLLNYLQATKLGEVELLLAIRSLMLSMDLLPDTNKLNKLKLLANEAHEEGDTQEVDLDDLEREIAVTEHYLGDESSSRSRGLTLAFTKLWRIPAIATVKALRDTVRTEEVLAFIYILRVELVRGAWTTLYIDPTSLDSEGNDPPPDGVITLIADLLGRCLDAVGAGGWLFNDAMTWADKTETGDFLTALKLEVAAALEGLEEAVLLNGIVGEAVRYGLTAEKNWAARQVWTPNKPISLHLEGKESRLLPLGLKMKLLPTREKVVSGGEVVNRTSRETGHMISQKVEAYSLEKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWF8</accession>
    <name>A0A7D5YWF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkylmercury lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g078400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545268.1">
        <property type="nucleotide sequence ID" value="XM_014689782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWF8"/>
    <dbReference type="GeneID" id="26241301"/>
    <dbReference type="KEGG" id="mbrn:26241301"/>
    <dbReference type="OrthoDB" id="4379184at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018836">
        <property type="term" value="F:alkylmercury lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004927">
        <property type="entry name" value="MerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053717">
        <property type="entry name" value="MerB_lyase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03243">
        <property type="entry name" value="MerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160387">
        <property type="entry name" value="NosL/MerB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25292" checksum="839659FB3D192954" modified="2021-02-10" version="1">MDHSSLHEFIISSFLKNQRPPTVGDIATRFESDVPTARQGLRALADYHGVVLHPQSDEVWVAHPFSAAPTTCIVTSGHRKWWGNCAWCSLGVMHLAGGTSTLTTRTGAIGDEVSVTVRDGQLLDTDFVIHFPVPMRHAWDNVIYTCSVQLLFRNEAEVDEWCATRGIAKGDVRPIKQIWDFAAEWYGRHADADWKKWSLHDAVEIFARHRLTGPIWTIGDEAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX60</accession>
    <name>A0A7D5YX60_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g045690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544696.2">
        <property type="nucleotide sequence ID" value="XM_014689210.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX60"/>
    <dbReference type="GeneID" id="26242037"/>
    <dbReference type="KEGG" id="mbrn:26242037"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="478" mass="51727" checksum="2FD9026D33F86BF3" modified="2021-02-10" version="1">MLTVKQPPAYGYRSVHDLPTPPSTSRPSPPLSYSEAAYKHHQVVSRSHSPSSQAMSAPHRGLPPPAAMALPPQQAPPSAAVPPQHHGHQQPPPPPLSAGQGGPQAQPWTSLPPPPGQWHGSEESMRTWLQAKTEEEKTKQEEEKTRQEGLRLEQRRVEMDMLRDSLRGGIPPPMIPLVFAGMAAGGTLPQTAVEWAQQFLSPVQSQPLQLLPPQRQHSPDPHQREGASQGQYPGPGAAPPPGPGAYGPYPGSPTRPRGQTVSGVVGRSSIPAGGNPSQPSQPGGAGVSPYGSQTHMHTQPAPQESSPGLYFHHWQPPATQSGSGSSNRPGTPSGESSKKRKATGPQLSGTPGEQRLRSPPPFIQSSLSNPPPGRKGGHKRQRSDVPWYRPSSHHHHHHSEDPERGPRSVSPPRDGHPEFSQERYGGDSSKHSVSTLLTHEPSRSQFNPTHEPERPMPRRREEEGMPRERTPPRTSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXX7</accession>
    <name>A0A7D5YXX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline ceramidase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Acer3_0</name>
        <name evidence="10" type="ORF">G6M90_00g058370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544413.1">
        <property type="nucleotide sequence ID" value="XM_014688927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXX7"/>
    <dbReference type="GeneID" id="26242825"/>
    <dbReference type="KEGG" id="mbrn:26242825"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="30162" checksum="8BE51B40B008BAA1" modified="2021-02-10" version="1">MGHHNIRFDGDAHSLGGAWSPPTSRANFCEEDYALTLYVAEFINSLTNLAYVHLALRYMYGPGSAGLLAPKIDFMSASLFVLGIGSFLFHASLRQTLEFADEFSMLGLTWAMLQATLTTGQSRTKSRLVSTGLAVCFASFAIFYLQSPKIIYQVIAFVACVFVLILRAQYLLYWLQPALPEVKRRDWNKRTWNAVFLCVLGYFLWNIDLEYCAALRSIRQQLGLPWAWLFELHGWWHVLTAIGAAQCMNVAREVRQEVERGQKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZB6</accession>
    <name>A0A7D5YZB6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g106530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539869.1">
        <property type="nucleotide sequence ID" value="XM_014684383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZB6"/>
    <dbReference type="GeneID" id="26247308"/>
    <dbReference type="KEGG" id="mbrn:26247308"/>
    <dbReference type="OrthoDB" id="4934518at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028946676" evidence="2">
        <location>
            <begin position="20"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="493" mass="54639" checksum="489009936630F826" modified="2021-02-10" version="1">MISMMLWTALSLSAATAHGAVVPRQAGDFDLAGVILQSSQVQRHLTSTKRFMGKEFPYSEGPMEASKAALGDKFKDDYEHFVESERKCLYIRNSFIKEATQSFFDVVPNVDAPDTITEEEEETGSVTESKAIVDTQRIGWNKEESTEIGGSATVGIQSGISAFSVSLSATIYGNQRTTGGQYGEASKQTEYTVTETKNWKCPKNSICRHVTWTYTRTLRGKCITTPYYDAQCANSKHSKAKFSLALFGKCTPSVRAGDQFYTYSDNAFGDFDGDLNTKIPGYGPDNQGIKMPKPDVIASHKFADDECTFTYVLRDKSGSPVRARGNLIEKDSSPLSAQPKVTKVPKAVKWIKGQKDQSVCELEGGWYWMPGNQWYISPKDGNTAKKWARRAELPDPVDLEKNCPENGQAKSKRDLPPANDLSDVPANDLVQIEITQDDMPAFLAELEQSQSEGFVANTIDDKAQPVRREGWGYPPGRNFEHCLDQNIKQNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZK9</accession>
    <name>A0A7D5YZK9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FAXDC2_1</name>
        <name evidence="7" type="ORF">G6M90_00g052280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540358.1">
        <property type="nucleotide sequence ID" value="XM_014684872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZK9"/>
    <dbReference type="GeneID" id="26246720"/>
    <dbReference type="KEGG" id="mbrn:26246720"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="115"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="28959" checksum="C82390EA904C12A4" modified="2021-02-10" version="1">MADLFESITSSQDVYTVELGVHFALQILFWWLPGITLVSLNYLAPSFSTRYKIQPAEKQPTLLDIGRCVAVSICNQAIELLLHFCLLNYYTSRGREATVRMTGDLPSLAEFTRDFVLSFIAREAIHYYLHRLLHWRPLYKRLHKIHHNFTAPMAFASQYAHPVEHILLNVLPITLPLVVLRSHVLVLVVMVGWDLLATSVAHSGYDFFLGLAKMHDRHHERFHVYFGSSGGFGIMDWAHRTNEESVVQKKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZM0</accession>
    <name>A0A7D5YZM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g052630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540390.1">
        <property type="nucleotide sequence ID" value="XM_014684904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZM0"/>
    <dbReference type="GeneID" id="26246752"/>
    <dbReference type="KEGG" id="mbrn:26246752"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="436" mass="49098" checksum="36ABE0B161405BEA" modified="2021-02-10" version="1">MNHEHYHSRIDFVKSILQLNHLEATSIEPVEYDMDGPPFPYNNFIYLVTLPSPTTTTIKIKSSQFAEFQPGTVPFPANATSLIFRLANSHPGTGLNNTNRIENEVAFMTLVRQALAKSKYSHIVPDVYTWAGTSSGQGFSIQQYMHGTMPDRGFEDLTLQDKSVVLGQMADILALLQQFKIPTTVDRFGGLKFDEDGKVVSAQMTLFKGEPCTTYKDLLSAIFKVKFQEADENPVIRGWRENGVRAKLENFIVYRLKETLKDYKDVRRVLVHSDFTTNNLLFDATTLQVTALLDFDFSYIGTVADEFMGFSFGNISGGKLPGPYESPSNLNLRNAMLRGFSKSCLNADCSEVQWDVAKAWDEELARAGAARPHTISHFEQIADIYWLQDKVSPFELDSPFMRMRKTAEQLKAARDETESLIVRFLECTSAPSDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZS0</accession>
    <name>A0A7D5YZS0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g106800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539895.1">
        <property type="nucleotide sequence ID" value="XM_014684409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZS0"/>
    <dbReference type="GeneID" id="26247334"/>
    <dbReference type="KEGG" id="mbrn:26247334"/>
    <dbReference type="OrthoDB" id="3343459at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="217" mass="24386" checksum="D471AAF5B71DFFB5" modified="2021-02-10" version="1">MAMTTTFTIQENAEDLQFLAGSNYNLQVAKAVSSPGGKPTFNVVYKSKSLAPNISVSWSPTYGLNWSRKRANPGAKVLYAGNWQACDLGQSYDLTKVGEWVINNNDTNRDPNSVNVGNNGYPEAVNIVVGILNPETQKWEAIFVSEDQLPPQGFGEYQPREEVALWYQEEIRTETMMSHQSTKVEKFDMTGKALQYFWYRAVSGEWENSPTSFPFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0D6</accession>
    <name>A0A7D5Z0D6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Actl</name>
        <name evidence="4" type="ORF">G6M90_00g016340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548894.1">
        <property type="nucleotide sequence ID" value="XM_014693408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0D6"/>
    <dbReference type="GeneID" id="26238338"/>
    <dbReference type="KEGG" id="mbrn:26238338"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43800:SF1">
        <property type="entry name" value="PEPTIDYL-LYSINE N-ACETYLTRANSFERASE YJAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="175" mass="19391" checksum="DCBACBADF3501394" modified="2021-02-10" version="1">MLTVRPATRADAPLLPAVERSAGQAFRQIQDLAWIADDSGQSVERHLTLIAQGVAWVAVDAGLTPEEVPVGFLNGEILDGNLHIWEMSVDKDHQGKGIGRALMAQAKKWAVEQQLPFVTLTTFRNVPWNEKFYKSIGFVTLDDGEVTTALRKVLDDEVRDGLPAERRCAMRLSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0I9</accession>
    <name>A0A7D5Z0I9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">serA_1</name>
        <name evidence="7" type="ORF">G6M90_00g108480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543998.1">
        <property type="nucleotide sequence ID" value="XM_014688512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0I9"/>
    <dbReference type="GeneID" id="26243385"/>
    <dbReference type="KEGG" id="mbrn:26243385"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="60"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="154"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="384" mass="41596" checksum="6A2177C23E162AE6" modified="2021-02-10" version="1">MLLRPSPSLWSSVARQRTATRRPSLAIIDDYLNTSGPHFAHIPSSSLQVTTFNDTILPANETETARLVDRLKPFELISTVRERTAFPGALLRRLPNLKLLLATGTQFEEFDLAAARELGIAVVAAPGRGRTDQVAAGHNIKKGRAHPTTQHTWALIMALARNVAADDCALKAGHQWQSGLAMGLTGLTLGVVGLGRLGAAVARIGHLAWGMRVVCWSENLTQEKADRMATEMGLSPDGGVDGGKTFLAVSKEDLFRGADVVSLHYVLSARSRGIVGAEELEQMKSSAMLVNTSRGPLIDSAALLDTLERGGLRGAALDVYDVEPLPLDSPWRRANYWGAGGRSRLVITPHMGYADEGLMNAWYAETAENVERWLEGKQVLHRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0P9</accession>
    <name>A0A7D5Z0P9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g013140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549209.1">
        <property type="nucleotide sequence ID" value="XM_014693723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0P9"/>
    <dbReference type="GeneID" id="26238653"/>
    <dbReference type="KEGG" id="mbrn:26238653"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="29105" checksum="EFB3471B99F2F7AD" modified="2021-02-10" version="1">MAPETPKGVSSRLLTMKFMQRAAASASSNGSPGSDVPSSKKRKLDYSPAPGRINPNIDHALIQAALDDQEATRQAALAKHSAADTHWVLKANIDKSQDKKQSHPLNIVYVGYGDIDASKDSDENEDNPAEGRTYHKPLKTEQSNERCNSDKSGDESRRTSDDESDSIGRDHTTGSSDENKRMTTSRSRSRSQSRSRHGHQASKAKEFRDKRKKKEVRLNKLTSISSVGNGNFSSQGSPSTKAIKCYNCQQLGHRASECSKRSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Y5</accession>
    <name>A0A7D5Z0Y5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Late secretory pathway protein AVL9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AVL9</name>
        <name evidence="4" type="ORF">G6M90_00g024980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986032.1">
        <property type="nucleotide sequence ID" value="XM_066129945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Y5"/>
    <dbReference type="GeneID" id="26237527"/>
    <dbReference type="KEGG" id="mbrn:26237527"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="43"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="721" mass="80135" checksum="44814C2E5EB6CD19" modified="2021-02-10" version="1">MTSEDIKYKHNGANSPDGADVEPALTPISLVNTDSPAGSGFSPLVTVVGFHHARGPEVETWFGADEGVDPAIKYNWPLLPFMALSDGAHASEEDFSYFTLLKPKTNTEPATSLFGISLQKAVVVIADSPQSFGMLRERLSIVTQAWFAQREFTDTEILRRFQESLADEKARGLVEEDTERDQHLGMSLREFIHEFKWQALVLLKCCLLQPKMLFFGSRCDRLCMVQFSLISLIPGLIRNLQDCADPELDSYEKKLAKPTTLQSSNRNSLLTFMGLPLQIFGKGGFFGPYTPLQQLDILADFGTKSYIVGSTNSLLLQQKDRYSDVLINLDEDTVSITSPSLKAALALTPADRRWIDFLTHEVNETWDEANPSRPKNMQYIGSEEFIRSQFEAYMLGLISSVKFRNFLISQGEDPSTLGADSDPAVDFGSEWVEAWKKTENYRIWDAHTDTNLFAVSEPKHPCAGGLTIDDIQRRVADQIKDLHLDERLAQGRDILGRNLAAGREKASTMLNKLYSDVEYLRESQRRRAEDSRTQTTNPKSSTEKSQYPVDLTKAQQTMNSVGAKASAYMSSWATWAGDKRKTGGWASGWGGKKSPSPSTHNNPPISTSPIDKDYQMVSPPDSRSTSTDDPKRHATHASFSESILSKTSERPVSGSSEMDDSFQDVMGSPEKVSHKQKDEDVTPKLNNDGFQQEDVMGAKMSEKGGMDDTSEGKGTEVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1V5</accession>
    <name>A0A7D5Z1V5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cya-4</name>
        <name evidence="14" type="ORF">G6M90_00g008110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549697.1">
        <property type="nucleotide sequence ID" value="XM_014694211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1V5"/>
    <dbReference type="GeneID" id="26239141"/>
    <dbReference type="KEGG" id="mbrn:26239141"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="169" mass="18423" checksum="D1630B4E202E8747" modified="2021-02-10" version="1">MLRTPASNLLRKGLVRSVPAAASRASSTHAISNPTLKNIEKRWEGMPLQEQADLWMALRDRMKGNWNELTLQEKKAAYWIAFGPHGPRAVDPPGTNARVAWGIAVGLAASFAIFAAIRSFAKPEPHTMSKEYQEASNELLIQQKADPLTGITSEGYSGKGMVQSPPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1W5</accession>
    <name>A0A7D5Z1W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hsp60</name>
        <name evidence="12" type="ORF">G6M90_00g050320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986175.1">
        <property type="nucleotide sequence ID" value="XM_066130486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1W5"/>
    <dbReference type="GeneID" id="26242480"/>
    <dbReference type="KEGG" id="mbrn:26242480"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="583"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="732" mass="77843" checksum="107C49E3C1ED13AE" modified="2021-02-10" version="1">MQRALSSRARATALSSAASRYRAGAGLGQQLRFAHKELKFGVEGRAALLVGVETLAKAVATTLGPKGRNVLIESSFGSPKITKDGVTVAKAVSLKDKFENLGARLLQDVASKTNDVAGDGTTTATVLARAIFSETVKNVAAGCNPMDLRRGIQAAVDSVVEYLHKHKRDITTSAEIAQVATISANGDHHVGQMIANAMEKVGKEGVITVKEGKTMQDELEVTEGMRFDRGFVSPYFITDAKAQKVEFENPLILLSEKKISAVQDIIPALEISTQTRRPLVIIAEDIDGEALAVCILNKLRGQLQVAAVKAPGFGDNRKSILGDIGVLTKGTVFTDELDIKLEKATIDMLGSTGSITITKEDTIVLNGEGSKDAISQRCEQIRGVAADPTTSEYEKEKLQERLAKLSGGVAVIKVGGSSEVEVGEKKDRFVDALNATRAAVEEGILPGGGTALIKASAQALGDVKAANFDQRLGVNIVKNAITRPARTIIENAGLEGSVVIGKLTDEHAADFNRGFDSAKGEYVDMIESGILDPLKVVRTGLIDASGVASLLGTTEVAIVESPDEKGPAGPPMGGMGGMGGMGMIATVSQECITAYNDLKLSKKYKYIIFKLSDDFKEIVIEEASDDKDWDNFREKLIKSTTKNKSGVVGKGCRYAVYDFEYSLATGDGVRNKITFIAWSPDDAGVQPKMIYASSKEALKRSLTGIATELQANDADDIEHDTIVKTVSKGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z254</accession>
    <name>A0A7D5Z254_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FPR2</name>
        <name evidence="10" type="ORF">G6M90_00g057680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544350.1">
        <property type="nucleotide sequence ID" value="XM_014688864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z254"/>
    <dbReference type="GeneID" id="26242762"/>
    <dbReference type="KEGG" id="mbrn:26242762"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028997680" description="peptidylprolyl isomerase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="174" mass="18408" checksum="7A34E9DA1D0A96F5" modified="2021-02-10" version="1">MKSITFLSVLAASAVGLGAADGLKIDVTHSVQCDRKTQKGDKVAMHYKGTLGDSGKKFDASYDRGQPLQFTLGAGQVIAGWDKGLLDMCIGEKRTLTIPSELAYGDRGIGPIPPGATLIFETELVGIDGVAPPEKETGKDEAKENKEADKAGEKVITVVLKATEAPKTFMADNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2J4</accession>
    <name>A0A7D5Z2J4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g047010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544824.1">
        <property type="nucleotide sequence ID" value="XM_014689338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2J4"/>
    <dbReference type="GeneID" id="26242165"/>
    <dbReference type="KEGG" id="mbrn:26242165"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16517" checksum="CA5999A4778D29E1" modified="2021-02-10" version="1">MANSYQALYPGDMAVSPEIVQFFEDFYRISDIPGEHDQYVDQFTQDAIFILASKKSHGKQEILATRIGMWSAVASRKHTVHKVFPFSNESNEFMLYGSVALGLRNGAHADVDWAARADIVKSADGKWRMKFYQVYLDTGAITSPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2N4</accession>
    <name>A0A7D5Z2N4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g070690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987104.1">
        <property type="nucleotide sequence ID" value="XM_066130938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2N4"/>
    <dbReference type="GeneID" id="90967929"/>
    <dbReference type="KEGG" id="mbrn:90967929"/>
    <dbReference type="OrthoDB" id="5141885at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="154" mass="17283" checksum="820666846769EA08" modified="2021-02-10" version="1">MSQLSATVASLPCKWPASVGSTTKHEFDDTKAYSVTLEVSPDGSRRRVGVVVDRYDKNQHIMSALLWVECKRPGGSLREVEKQALDADNLSFPYTMTTVGVSFRMPFYQRGGRHLTPFHGEATSADRTQYVDADSQNAIYIRDTKTTQTLYQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2W5</accession>
    <name>A0A7D5Z2W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g077720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987163.1">
        <property type="nucleotide sequence ID" value="XM_066131076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2W5"/>
    <dbReference type="GeneID" id="90967990"/>
    <dbReference type="KEGG" id="mbrn:90967990"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9523" checksum="B7978453874CB82A" modified="2021-02-10" version="1">MAKKAEGGSAIPTSKLERWLETRQIRFDVSIVKPRDFLQKGWKEHKDKWRLLAAAARHLLSVSGSKVGVEGLFSGCRDEFGICGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Z4</accession>
    <name>A0A7D5Z2Z4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 35 member F6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g088380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542274.1">
        <property type="nucleotide sequence ID" value="XM_014686788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Z4"/>
    <dbReference type="GeneID" id="26244788"/>
    <dbReference type="KEGG" id="mbrn:26244788"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44702" checksum="4996C29E8EA4D3FC" modified="2021-02-10" version="1">MASRAAVPFLVTMMLVTGVCNTLLTKYQDNQCVRDCHGKRPQLFEQPVLQTAQMFVGEMGCWLVIALMAAYRRIVSRPSPEERGYETVNTTENAEHEEHRNRPKPDGDCPSVLRGFRVVLLALPAICDICGTTLMNAGLLLVAASIYQMTRGALVLFVGLFSVMFLRRHLHLFQWLSLVGVVLGVAVVGLAGAIWPDEKQISQNGGSSLVDDGSSGGLSDAARAVIGVLLIAGAQIFTATQFVLEEWMLENSTIAPIKVVGWEGIFGFSVTLLVMVVMHFLVGRTEAGRYGPFDMAEGIRQISQPKIWTSSVLIMISIGGFNFFGLSVTRSVSATSRSTIDTCRTLFIWIVSLGLGWESFKLLQIVGFALLVYSTFVFNGIVQPPLESLRINEEVEELLPEEPIEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3W9</accession>
    <name>A0A7D5Z3W9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g039350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547289.1">
        <property type="nucleotide sequence ID" value="XM_014691803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3W9"/>
    <dbReference type="GeneID" id="26239852"/>
    <dbReference type="KEGG" id="mbrn:26239852"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="244"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="574" mass="62159" checksum="7170CD89ECBCC629" modified="2021-02-10" version="1">MPCFKGIAVSIHANGAPLPEYGMQKQSRVSRISTYIPVPQPNLTADSNKPEPAKFAISITLLTAGLAIPYSAPKPTDSNPYPKPQYVGSLQPASGRDRPKFGGMVNPYIPMTNSENETIAAYIYFDGRAKEEVATLLRPGEETWVNSRWVQVPDAEGGGLAEREFLFREVGLERWLNGLDLQGHDAAEKLEKRRQKFEKRRRRQTLVQEAGTGTDTSGGQKDTLRYGADDASPIEAVFDSDSWSDDDDEPPEATGQIKVAMFRVLASGEIKKGEYSPQFDAHDGDEETGNGENVGADVEHTTSFAKPKTLDPKTISTQTVTGIDGPDRPYAVFTFFYRGDRQLQKIGVVQSSKNPQATPGSAKRRSGQLDFSNLGPLKAGGTVGFSAFRDQTTETTRRRKARKKSNGNIAEDSDDDDDDDDDSTDNLNKMDDDDKDGEEKEASEDSKFGGELADGVNRIRLKRAHSADPDSHSTPETSQRGQAEDSPVPQVPPSLQPPSFVQSGSDVPVDALIGSPLKKARPSVDVTNTGEKLSTTQSLSAALDAAVSVTSAPATTSTTTTTTPPSKVDEEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4I6</accession>
    <name>A0A7D5Z4I6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nmt1</name>
        <name evidence="13" type="ORF">G6M90_00g040910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547438.1">
        <property type="nucleotide sequence ID" value="XM_014691952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4I6"/>
    <dbReference type="GeneID" id="26240001"/>
    <dbReference type="KEGG" id="mbrn:26240001"/>
    <dbReference type="OrthoDB" id="434407at2759"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000187">
        <property type="entry name" value="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="38306" checksum="EFB9073A721AEC3C" modified="2021-02-10" version="1">MSTDKITFLANWHATPYHAPLYLAQAKGYFKDEGIKVALLEPNDPSDVTEIIGTGKVDLGFKAMIHTLAAKARNFPVLSIGSLLDEPFTGVVYLKDSGITTDFRSLKGKRIGYVGEFGKIQIDELTSHYGLTPADYTAVRCGMNVSKAIINGDIDAGIGLENVQMVELEEWLASQGRDKSDVQMLRIDELAELGCCCFCSILYIGNEKFISENPEKVRAFMRAVKKATDFVLADPHQAWKEYVDFKPVMNSPLNWKIFERSYAYFSQDLKNVERDWDKVTKYGQRLGVLSPDFKPNYTNDFLGWGLEPDSADPTGDQKRMVELQRNVACCGGFHRLPLTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Q2</accession>
    <name>A0A7D5Z4Q2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g059950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544563.1">
        <property type="nucleotide sequence ID" value="XM_014689077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4Q2"/>
    <dbReference type="GeneID" id="26242975"/>
    <dbReference type="KEGG" id="mbrn:26242975"/>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF2">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="790"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="970" mass="111374" checksum="6A59FA8A89D384FD" modified="2021-02-10" version="1">MSDRYIGYVPTSSGRSPTFNPARASMPTSVGYSSMYAGDMHVVPSASQRHYITPRGYSTSTTASGVPTTTRTYAITQDPRGNSRTRDGSRTRRSTLDSTSRPPVIITTTQLDRSHGSSSHSGNARSGSPVRDEYRASDGQVYSQPASSLRSRNTASRSYHAPSPSEDFGRYRDRADSHLSSRDIEAYRNSRPSVVYPSDPRHSTAAIDYGDDGYQYTNAGELVKYDLDQSKPSRSRRHDRHDSFDAGYYRPNVNYDLDRRNLNINTSHDLNRPPNGPSSRQHDGRPGPPPSTRGFDKINRAYDSRDAPPAAPVPPSPTSAASLLEIPGSSGSVRRPRPLSLHQDAGLRSSHHDELYRSREDERVMRAMRDRDFDRRSEPPRFYDESVTSRGFGIRTDVLNHPEEIKERRRESRLDDQRKRSDEEVSYGSDKDREGRRWSRQDPTDDRRDRRQTKRGEENQDQERSRTRETLTGGLGAAATAASLVASTKSGEKKDPGAPGEKRRRSPPEDREIHKEVIVEQDARQSLERASKPMGGKEGTRERESLREKEPLQERNPTTKERPPASERDVFVPKELVREPAPIRERDPVRESVRDSLRDKESMREEPRDGGSFERRRPDADTRTIREPVRASGSDSDDTNRPPRRGRASQAFNPNDASDLKQLKEQLASMEMSNKRQEKEVERPALAEKPEKPRARSPSPSKEQAAAGSSREPSQEKSSEESRGRELVVPEAEGKQVRVVSPPKDKSEGKPLKGILKQPKASFPEEANPVREGVAPHKEDKKLKDAPPGARWTKINRKIVNPEALTIGKERFEVRDDFVIVLRVLSKEEIQAYAAATQVLRERRRTKIEGKKEGDNDYGRERDTMRDEAGEEDEERHHRHRRRRESEEESDEKERHKNRDRDRDRERERDRQRERDRESEREGERQRHHRRDQADDYDNRARDDHYHHHHHNNHRSFRERERERELEAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4T8</accession>
    <name>A0A7D5Z4T8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aro-8</name>
        <name evidence="8" type="ORF">G6M90_00g057590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544340.1">
        <property type="nucleotide sequence ID" value="XM_014688854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4T8"/>
    <dbReference type="GeneID" id="26242752"/>
    <dbReference type="KEGG" id="mbrn:26242752"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="478" mass="53692" checksum="4D2C08A8A8BFA5EF" modified="2021-02-10" version="1">MASQPWTPSTWRSKPIKQAPSYPEPEKLTKVVKELSRMPPLVHPNEILALKAHLRDVAHGKAFLLQGGDCAELFDYCEQGAIESKIKLLLQMSVVLIWGTNKRVVRIGRMAGQYAKPRSSPTEMYQGREIPSFRGDILNGYHVDERDIDPNRLTKAYHYSAATLNYIRTSIASGIADLHRPLDWGLGHVRDPVLKEKYSSIASSIQQTLRFLQVINSRPDELHTVELFTSHEGLLLEYEEPLTRLLESPPARPAPPASSRAPSPPLPADDDEPKTQQAYYDTSAHFIWIGDRTRQLDHAHVEFFRGIANPIGVKVGPTTPTSDLLDLLRTLNPDCEPGKITLITRYGANKVGELLPKHIRAVEDSEYRRCVVWQCDPMHGNTLSTPSGIKTRRFNDIYKELQESLRIHKEQGSYLGGVHLELTGDAVTECLGGSEGLEEDDLSTNYTSFCDPRLNEKQALELAFLVADHFSQEQKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5Z7</accession>
    <name>A0A7D5Z5Z7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoporin NUP82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NUP82</name>
        <name evidence="10" type="ORF">G6M90_00g086400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542474.1">
        <property type="nucleotide sequence ID" value="XM_014686988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5Z7"/>
    <dbReference type="GeneID" id="26244988"/>
    <dbReference type="KEGG" id="mbrn:26244988"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI72723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="886" mass="97783" checksum="E7ED24470DCDCB68" modified="2021-02-10" version="1">MPKVKSYSSAWLSNNNAPGRQLFEPSAEAIRSRALSPPSKTRSTLGPRRTIARRGTEVFVAVGKEIRWADLAYLKDEWSTRQPRGRTGTRSAGARIKREDSIQSIDDGEMDAAPGLRIIKTPVADEIRQLIISPNSNYLAILTTHTVHICAIPDSSHLTSEDTSPLRPKIYTLGPTTHVTSRAPIMSVLWHPLGVNGSCVVTVTADAIVRIWELSTQDRWSFDSPTTSVDLKKLVDGTTLDQDFSASSSTTNKAFSPDSFEMEVSAASFATKGSGGWNPMTLWVAMREGDVYALCPLLPQRWAPPPTLIPSLSVSIVTTVASIEDDPAVDENEKLLAQQQLQWMGELDAQEPQVLESLPGEPIVEVFTRPTQPGVVPRLQGPFWLESDPETGDDLDTTITDILVIGKKTDTDELMLGEDEDLDLDDGDQEGLSLPVVCLLSASGQVRVYLDLEGIQAQWLPPRNKAKLGRLPTPSSPPSLLAFQAIDTMSPIEISEDSWPVFSNDAMSRYSFFVTHHAGITFVSLTSWVFRLEGELLADHKAGTDFRIGLLVNSQSTRDRIYAQPSADVAVPLAACVAIRDPDLGYFLLSATPYEPVALTFETQDVDLAPIKQESPVREREVSMAPLDFYEPRPVYNPPHVFDEGSALPTLLERLRTSRHKTIVNQEVRLSPLTLQIFTDAHKVLSDETYKLGVAAAEVFRRCELLQSELHQQVRKANEVKGKIDSINGADGDGEGEAENAMYDRRIAEARDRQERLTKRVDNLRKIVGKATTRDLSTKERAFVDEVRSLEASVLGPSGGQGDSAAQQSKQLWKRLEEVRTLQTELVAEVESLKKSGEVEVAATGDVRIPQDIRRSKLQQVQGLLARESALVEAVTMRLQRLQTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z636</accession>
    <name>A0A7D5Z636_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986487.1">
        <property type="nucleotide sequence ID" value="XM_066130349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z636"/>
    <dbReference type="GeneID" id="90967684"/>
    <dbReference type="KEGG" id="mbrn:90967684"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8044" checksum="DCD4B0F8F8811E53" modified="2021-02-10" version="1">MHPFSILTLGIFVAGYITARWDLVTRLYELAIFAAEYGVVIRAAKGVVALTALFLTIFIPVVWVARKETFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z644</accession>
    <name>A0A7D5Z644_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWF19-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g101020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546243.1">
        <property type="nucleotide sequence ID" value="XM_014690757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z644"/>
    <dbReference type="GeneID" id="26240666"/>
    <dbReference type="KEGG" id="mbrn:26240666"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="300"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="464"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60418" checksum="CFCA7B22C49BF7FF" modified="2021-02-10" version="1">MAAPKIIILGSLNGQLEPVFNKLATLHAKNNFSLAILTGDVFTPDTDDETISALLNGSLEVPLPTYFTIGTHSLPERIATRVEAGEEICHNLHFLGKRSITKTSEGLRIVTLGGLLDTKVVGGQSKEQHLPFHTDDDAKGLKGANNADILLTSMWPANVWNGSQVVLGPTHQASIQSTQAIAELCATLKPRYHISASPEAFFYEREPFVHQSSSETEPTSVTRFISMAPYGNEAKAKAMYAFTLNKSDTTVPKGITASPFTPKRKRPLDDDEGGYSRFASHDNNRRGRQNKRRRESPPPGPDKCYFCLSNPNISAHMCCSIGDESYVTTAKGPLPTSTTFANEGLNFPGHFIIIPLPHAPTIPSMGPTSDPTSDAVKAYNEMSRFRESIQAMISAKSSHKLGVVTWEISRDRNIHLLWQLMPIPAEMIHSEIAEAAFRVEAENQKYPSFVTRELTLEEQPTFGDYFRVWLWADNGEDKIKGKSLVMPLSADTRFDLQFGRRVIAKLLGLEKRFIWQDCEQTVEEETADVEAFREAFKAWDFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z682</accession>
    <name>A0A7D5Z682_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g054170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540987.1">
        <property type="nucleotide sequence ID" value="XM_014685501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z682"/>
    <dbReference type="GeneID" id="26246293"/>
    <dbReference type="KEGG" id="mbrn:26246293"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028840170" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20424" checksum="21A3FC09DFD4D93A" modified="2021-02-10" version="1">MMTRLLITVIYLAASALAQVPPGWTNVFSPSNLYIYDVSNGAISDLSPTALVFKSPTNGGRDKTTLLTFKYPAGTNGKQCQLFFNFDQAADATSRWDGSGRLDIFSSNSVAPGKTSGWPPGNQRNNHLGRWKKSATPWADWEATYGGLSVPQPCKPPGTVQGFEIVGVYDNTYVTYTNALSGVRIAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6U3</accession>
    <name>A0A7D5Z6U3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545117.1">
        <property type="nucleotide sequence ID" value="XM_014689631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6U3"/>
    <dbReference type="GeneID" id="26242458"/>
    <dbReference type="KEGG" id="mbrn:26242458"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="1">
        <location>
            <begin position="57"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="21002" checksum="E421A12D2746CE6D" modified="2021-02-10" version="1">MPLCTSCRCLLRRALRPWQHFLSTSCKPSPAEMLSKPTWSVRSLRHPPPTTTAAAPAATEKITSSQLHHLLRLAALPLPQTPSEENTMISTLQDQLHFVRAVQRVDTTGVEPLRAIQDETEEARRENTITLADMQGLLDAEEHVGHYQRPRRVRTRIEDESSEKWDVIGTAGRKAGKYFVVESQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z716</accession>
    <name>A0A7D5Z716_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g068450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540598.1">
        <property type="nucleotide sequence ID" value="XM_014685112.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z716"/>
    <dbReference type="GeneID" id="26246705"/>
    <dbReference type="KEGG" id="mbrn:26246705"/>
    <dbReference type="OrthoDB" id="4940712at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="512" mass="56707" checksum="B0F2AEB6F5A67E3C" modified="2021-02-10" version="1">MSRADQDIVREGQQSPRLARTRSGRTRSNLEDVAEEFTAGNEPPPPPQTRGRRRASQTQVLPNQDSRRAPSRQASQREATPRQDPQRQPPRRQNTNGNSAESGDANEQEIPIGLQTSDVDMDRPTTEASSDTQSEPSPQPDSRPGPSGSGGRPARPSESIPRDHRRQRDRQPAADDNRSRRRGNAASDPNPQGLHSGTDTEHYDDGDGVPTFASEGEFESDNGESDDGEPTYGTLALDGQLQERNGRQYFKIIHPDTGYRETARIEGKAPSKNIVIFSTRPLEGYGSRPAYARRMADVGLSGVAIDEIQPMKKAEFFEFRRDGRLGILLVASLLPVPEPLQQHPMTWIKLQSGDDTKWIARSTFVGGYKEGQAFINRHYTATGQNPPPQPLPAAERRLLQAEGQQLRRNPPRAAQPERPPSPPAGSSRQNTPPVVRRTPRRTARDSRASQEPSTNAQRGNGSSQQPSSPRSPSPNRQRSTNQGREEARQQPNTRRRPSTSQQSGTFPEEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7G8</accession>
    <name>A0A7D5Z7G8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5 6">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tit1</name>
        <name evidence="9" type="ORF">G6M90_00g064430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 7">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5 6"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540100.1">
        <property type="nucleotide sequence ID" value="XM_014684614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7G8"/>
    <dbReference type="GeneID" id="26247136"/>
    <dbReference type="KEGG" id="mbrn:26247136"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="51731" checksum="3897238531F0DC92" modified="2021-02-10" version="1">MANSKAPAEPLLVVLGSTGTGKSDLAVELATRFKGEIINSDAMQLYKGLPIITNKITQAEQKGIPHHLLGHIPLHHLPWDVDDYKREANKVIGQIRARGNLPILVGGTQYYVDPLLFTDVILDEVQQTGPSASFPILEESTEVLLEELRKCDPVMAERWHPNDRRKILRSLEIYLHTGKPASQFYAEQEARKAAAASGDIPATPWEKLLFWVYSDRQILTERLDTRCDKMLNSGLLDEVHELYAFKKKSRETGQEMDMTKGIWQSIGYKQFEPYLNALEAGADATEAEKLKLSGLEDMKTATRRYANYQTKWIRIKQMRRLQDEGPEAVSSLYLVDSTDVSRLQTNVVEPAAKLTELFLKGEQRPAAVDISEMAREVLGGALELRPKETPIQRTCDMCRTVLVTEQAWERHVKSVGHRRAVKKKTKLALVAVDAQKGGEAKESADPDGSRASSPDIGSIFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Q0</accession>
    <name>A0A7D5Z7Q0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g078590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545249.1">
        <property type="nucleotide sequence ID" value="XM_014689763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Q0"/>
    <dbReference type="GeneID" id="26241282"/>
    <dbReference type="KEGG" id="mbrn:26241282"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="9">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="284" mass="30360" checksum="78B546FC055B0558" modified="2021-02-10" version="1">MTVDILPLELNFSRPFTVEVSRTLTIRNTSTSPLAFKVKTTAPKQYCVRPNAGRIEPGNAFDVTVLLQAMKQDPPLDAKCRDKFLVQCAPIPSDKDFSTIASVLESADKATLAERKIRVNWLAANSEDAQGLAAPAFSTPSKPSAVNGATETPDAPRTFSSPGGNANSTPLSAPPPYASDDAAEEADDKPERPKSAVSHAAASVSEAAQVSYEELKSKLAQAEAQLLNLKDSGLRQRSVKSASSEEKRPAANTAQVVKQQPDGVPVQIVALLCLLSFLLAYFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z938</accession>
    <name>A0A7D5Z938_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPN1</name>
        <name evidence="9" type="ORF">G6M90_00g068020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540559.1">
        <property type="nucleotide sequence ID" value="XM_014685073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z938"/>
    <dbReference type="GeneID" id="26246666"/>
    <dbReference type="KEGG" id="mbrn:26246666"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="387" mass="42470" checksum="5AD33EB1B24DFEEB" modified="2021-02-10" version="1">MASSDDASPPVAIVCVGMAGSGKTTFMQRINAHLHGKNQPPYVINLDPAVLNVPFDPNIDIRDSVNYEEVMKQYNLGPNGGILTSLNLFATKVDQIVNLLEKRAKPDAENPDRKPIDRIIVDTPGQIEAFVWSASGTILLESLASSFPTVIAYVIDTPRTASTSTFMSNMLYACSILYKTKLPMILVFNKTDVKDASFAKEWMTDFEAFQEALRQDEESDALGGVEGGGHGGSGYMGSLLNSMSLMLEEFYSHLSMVGVSSRVGTGVDEFFEAVEEKKQEFLRDYLPELERRRHEREKQKKKSRDKELDKMMSDMSVAPGQAAAGQQSGSGAGNDSDVEVASDDDDEDSDEDAAKQGLQERYQAAMGDGENSILADASFAKYLHKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAX7</accession>
    <name>A0A7D5ZAX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g082000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987280.1">
        <property type="nucleotide sequence ID" value="XM_066131187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAX7"/>
    <dbReference type="GeneID" id="90968055"/>
    <dbReference type="KEGG" id="mbrn:90968055"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="104" mass="11863" checksum="C0EB3257DB15997A" modified="2021-02-10" version="1">MSGDRLVGYPAYQQQQLYHKNEQHERQQPAVVPDGNSANRHPSRLASSQRWVLGKHRHENPATRGSDRENQWVLPEGRLGPTLPTWPRLAHEIPQLALHASPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAX9</accession>
    <name>A0A7D5ZAX9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g109950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543861.1">
        <property type="nucleotide sequence ID" value="XM_014688375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAX9"/>
    <dbReference type="GeneID" id="26243248"/>
    <dbReference type="KEGG" id="mbrn:26243248"/>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031213">
        <property type="term" value="C:RSF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028938">
        <property type="entry name" value="Rsf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296:SF3">
        <property type="entry name" value="DIKAR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14296">
        <property type="entry name" value="REMODELING AND SPACING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="496"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="577"/>
            <end position="605"/>
        </location>
    </feature>
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        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
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        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
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            <begin position="367"/>
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        </location>
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        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
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        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
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        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="726" mass="82248" checksum="C33BFA5509D6370C" modified="2021-02-10" version="1">MPSHKRVISGDGGDEPPSILHRIRNMWQFANLCQWIYMFGKAAKIDDAIDIEEIETDCLKPQPTLLSDIALALLKLVSTHRGLTPDVLDHQIRKQYLAKAPKQNPFGSEINPVSFSGLDVFTKVKVLQKLTQWTMVHPERLREKMVEHKDAEQSNWRIEPYGWDKHDRVYYVLDDNRIYRFTEPQSNGPQLKPRKTKQYRTGRRVSKRRRISSSCEDDVEDLSDRQYDSQPPEDDLGGGAWECIAITLQETKSFIETLAKTRDGNEKTLRKQLETHLLPILEKQEEATKRRELQRERELLNLAKMANAKRSSRIADKVQKKKRDVEEKKEQRQRLEAERAEHREKLVQLKLEQERDSRMHARQRRLKEREARRMRHEEELAQLSEDSKHAPESARISERRLHAEIQRNQQALKDIEQEEDDWVFDCICGLHGQVDDGTHSVACESCNVWQHSKCLGIPEDEADQSEFRFVCSSCRRRDDDKNASPKTIIKIKVRPSKIMPNAPTRADAHTVSEVKHDSIIQSGQDRSAEKPSSLVLQRETRPNGLAMVSNQPPSQATISRLGSHRDVESYKYCNSSNKASPNISGSTALSESQSLATHGSSTAKQDVARNAQAGELAQLSLSIVDTKAPIDTGESLSSAPYLAPGDSKYSGLRLNQTGYSPLTQQSPTIVMPATHTKDNLESCKGAAEERNSSSAPDSLPVSITSFAATPGFVSTPIRPNEEHEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBN1</accession>
    <name>A0A7D5ZBN1_9HYPO</name>
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        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g092920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Clavicipitaceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="entry name" value="DUF1275"/>
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    <dbReference type="PANTHER" id="PTHR37488:SF7">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
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            <begin position="115"/>
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            <begin position="154"/>
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        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
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        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28767" checksum="912C12DC7A80E9B1" modified="2021-02-10" version="1">MENPGRSDSDTDRQSKEEKPVVRKLSQNVDLKLAYLPMLACCFVSGLTDGTIYNAYGTFVSMQTGNTIFVALGTSGYNNKPYGWARSLCSIAFFIVGSFSFSRFALYLGGRRRGIMMLSFLIQAILVIAAASIVQGGVVDGSYPSKRLPTDVDFKELLIIALLSFQAAGQIVSSRTLKVGEVPTVVVTSMLCDLMSDPALFTLAKNDKRNRRFIAFILTLVGAICGGWISKAAGAVDPSLWTVAGIKLVIAFSWLFWKAEPDSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC47</accession>
    <name>A0A7D5ZC47_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g113000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
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        <property type="nucleotide sequence ID" value="XM_066131877.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:90968284"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="459" mass="51223" checksum="5A2EDF2EC9F405D6" modified="2021-02-10" version="1">MSFAEKSTALQNVMKNLDIGDACVLRKAFTYSSILKQCYESRADPVGYLSRTFRYPLTLLSAMFDSGCVITGPRALGFFLPSSTSEDSVWTFFVPGYKESVLDMVNVLEICGVSWQLDAAEVARSLRPLGTASISSADLECLNSRAESLEPAAAENLLGTALYGRFKAYKEMNCGNRLNSDACQLSDLEKPTLGVASEESAFPPSQDTSSAREALNVLQGYIQTSSGSQGVELIIGCSYSGINSCMSFIKGFYASHVQCFISGWCAGHMYYTQCKDKHSSMWRPWPGQKYRNAHLDVKKYRHRGFTFHRAKRGGPVTRSLRDSQSFLLDYGALYRSFIRPSHHALLDAWLAERRDNMDGITWTEFDGRIFSVHDTFESCYRQSRMTFASHSVDLPLNRLRRLSNLVALNLTEPDALRAESFRSSIGPPAVGQKWQLGALARTGKVFNNLRDATPWSWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZD71</accession>
    <name>A0A7D5ZD71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g099760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546373.1">
        <property type="nucleotide sequence ID" value="XM_014690887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZD71"/>
    <dbReference type="GeneID" id="26240796"/>
    <dbReference type="KEGG" id="mbrn:26240796"/>
    <dbReference type="OrthoDB" id="3498215at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="468" mass="51098" checksum="695474A9CF3A32AF" modified="2021-02-10" version="1">MATKLPQESKAAGTPKHRACDECRTRKLACSKDPTGCERCKREGISCVYSPQKPMGRPRKRRAIEQPVPEDASTDASRPQVLPTPRRVSFSLSSHQDPLANAHLDFMPQIDDEPLNFLDMLSNNPGDSDTAHLYPLPQEPYLSLSGPGDGSLGSNSFQIEFGGLDILQGIDFNEPEPTRGSISKHINDSLHQYVAGQMPRVQETPPSISSDVSSIIESPEPPQASTSSKPLPNSTCGCLSSLYLALDSLTRLPSDVPSAMRVARNATKISQDVLGCPHCFQYFFTDPLQPQPVQSLQNMTCLGALVPSACNAYARIMEMIDRDADAAHADGKGIFFSFREFGGLWGLVMDDHGGCAALKAIDNRNLDPDVWRATVQSILKLDVYGLGGKTGDALPGRHAILGLKDVINELDRSTKLRHQIVEDLMAAGKMPNHSRYYLQYNAPVPPEHRNCTRLVESARVALNNLSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZEC7</accession>
    <name>A0A7D5ZEC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="11" type="primary">prnC_1</name>
        <name evidence="11" type="ORF">G6M90_00g112650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540332.1">
        <property type="nucleotide sequence ID" value="XM_014684846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZEC7"/>
    <dbReference type="GeneID" id="26246926"/>
    <dbReference type="KEGG" id="mbrn:26246926"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="87"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="585" mass="64587" checksum="54FA25693BA523DC" modified="2021-02-10" version="1">MATRLAARTRPKLLLTTCSRSTCLVQTRTKVTIPFRLPDERNEPNPEYRRGSAERTQVERELARLRASLPVRSDIFYNGQAQAAQDSEMQVLPAENKTVFTNFPLASKEQVNKAIDSALLAKREWQEMPFVDRAAVFLKAAELVSGKYRYELIAATMLGQGKNVWQAEIDAAAELADFFRLNCNYAAELLARQPTRGTDGVWTRVEHRPLEGFVYAVSPFNFTALGGALISGPALMGNVVVWKPSPYCIYPSTLIYKIVLEAGLPTDVIQMVPGDAEQVTSTVLDHQDFAGINFIGSSHVFRSIYAKIGQGIGSKKYREFPRIVGETSGKNFQLVHASGDIPSAVNHAIRGAFEYQGQKCSATSRVYVPESRAQEFIARLKAGVEKMTIGSPDEDFEAFMGPVIHKHSFDKIKNIIEESNKDPCLELITGGKCNDSQGYYIAPTVYLAQSPDHELFNKEIFGPVLVIHVYPDAKWGETLQSVDKNGGGFALTGAVFAKDRKIIRQVEDTLRYSAGNFYINCKTTAALIGQQTFGGARSSGTNDKAGSSDILRRFTSPRTIKEEFSPLGAFTYPSNESGERNQAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPD5</accession>
    <name>A0A7D5UPD5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547929.2">
        <property type="nucleotide sequence ID" value="XM_014692443.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPD5"/>
    <dbReference type="GeneID" id="26237373"/>
    <dbReference type="KEGG" id="mbrn:26237373"/>
    <dbReference type="OrthoDB" id="4940299at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="26846" checksum="18FAC60722A1228A" modified="2021-02-10" version="1">MAAGSGGNGKSLRNNHDQVSSKVGVERLAGRNQSDVCPKSPLLIMNPQETQLLSGGSGTQSLWVETPFPVPRPDIFKSSPTVPFSLQEYLNDENGLERCIAGMPGQDRCSSSQERQAGQQASQLDTHRPSPVAVADPATNTGFFDSEYIEVDYAGLASARGYEAATTTTTDDLSGMERNEVTSLDSWSTLSCAPLTGSSSSSSTHSSSHSLLDPSYAPCSNSLRYESLHRQLQEAGLAGLGDGTNSIQLYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPI8</accession>
    <name>A0A7D5UPI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histone chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RTT106</name>
        <name evidence="6" type="ORF">G6M90_00g010030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549513.1">
        <property type="nucleotide sequence ID" value="XM_014694027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPI8"/>
    <dbReference type="GeneID" id="26238957"/>
    <dbReference type="KEGG" id="mbrn:26238957"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="243"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="499" mass="55061" checksum="6896E73A9C75C3DD" modified="2021-02-10" version="1">MSTALDSQRLGLIFQSRPDIIEGINRAADSPGRIALFNEIAGHVYDQLHNGGEPALKKRKVDTPMNANGTQQAEVSSGNASDEPVLLHIKEISVSVPQRKKFEICLTQNFVYARAPGTTVPIPGITYAWKDIEYLFYLPVPEKAQIQHNYVLFPRATCLPSRTNPPTIEPLVFTVPATAPKEGTIGGTEASAAAAVSDTYKSLFHWAFDRRLRAAGNAHDIISADPNKFHSVVRQPHRPNERAVHVSGFRGSKDGYLFFLENGILWGFKKPLIFIPLDCIAAISYTNILQITFNMVVETFSGEGEPNEELEFGMLDQQDYGGIDDYVKRNRLQDRSMAEQRKAKLQLAENRGPKKGSDDAEGGNAEGGTELEKAQLEAEQQLQDDEDEDEEDYDPGSEGDSEGSGDSSDENGDDDDDGDGDGEEYDDDEEGVEEGEEGEEEEEEEEEEVKPEPVSKPVQPVGAAQSKKTSQVPVRQGWATMASSRPTEDVDMEEKFEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPU5</accession>
    <name>A0A7D5UPU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pentatricopeptide repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PTAC2</name>
        <name evidence="3" type="ORF">G6M90_00g021910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548360.1">
        <property type="nucleotide sequence ID" value="XM_014692874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPU5"/>
    <dbReference type="GeneID" id="26237804"/>
    <dbReference type="KEGG" id="mbrn:26237804"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1052" mass="120006" checksum="27C5C3855E0AAE73" modified="2021-02-10" version="1">MVATEVDTGVALFRCSEGLGQVADQPGEYMPRPGSGAVRTQISDTPREKIQSTSHGSRRESVKANDTSRSSRKAHPETLKDLLSRPDEKNYHDVWDLYCRLDESQKQDLRALVVIYLSASHGSVERGRAISILRQIPVQLWDEKLQAAGVLLYLHAGDRTAAIDVFNTGLATKSSGAGFKSILEYAIINKEWPIALKVWLDYNSHFTRSNMATSSIYADLPLLKLVPDLAKLYFSFEHYLAVEAADPVKAIHLYEDTRQGLRALRRWLAQQVLRQPCSPREAKTILQIWNDETLYRSYLLRMLRRWNDGLETRASLAMLPEIYRQYRTMYHAKPPRLLLRQMFNFYYPADAAGLAQIYSDWHQAWGDLDQWGYEKFLQFYSTTGDVPAVKDLWARYTNLFPEAPKTPQAFRGPMNVYAQLGDVAGAERELRIMTDQYGVKPDIDTWNMLLKCYSKTNDHARVLQCFEEIKRLHQPDSFTYAQVMAMAAKKGDLATTLDFYNQSQKAGVHISREMAMALVLVYCHNDRFIDAEKICAEFAERNLSSTAVWNQLIYFNGLRGKLNKCYSILQSMTKYGLEWDHQTHQYLLQALVQVNQVQQAYRLLRNACDNSLFPLGPEHFAVVMTGAVRTGQLDLAETILSHMRSAGFTVPLSAHVSLLEAAFRRGPSAQNTRALAKDLVERLYSMLQPTKTAVPSGCPDVPSWDTLTGPVELKKQTNEIGRAIVLLVELRDFVAVERLVTAYLDVFPDFKKQNYFPPNIASALMLGYLKEGRRDQVHNMWRHTLDAALASGKTPEGAIYPALQYDLARPLNVVAKAYREVNDGPGLLNTVEQLTSAGFKLTRTNWNLCIRYLAEMGLWERAMDWCEDYLMSRWRGWMPATKSLQERRDMKNTRVLAASKATVFSLQKEWLKLRKLAAWSGSISSKLKEIERRHPMLHHAFITTDYEHLPATWMFPRKQSMTKAIKEMLSPLSHDELKAMRKALEKRLRLEKQKTRKAVRSPFHVVVGRSKTQGEVFTKAFKTGDLKTLDAVLKEELAANRGESSTSAQVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPW2</accession>
    <name>A0A7D5UPW2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 finger domain transcription factor mtfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">mtfA</name>
        <name evidence="12" type="ORF">G6M90_00g002610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542822.1">
        <property type="nucleotide sequence ID" value="XM_014687336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPW2"/>
    <dbReference type="GeneID" id="26244195"/>
    <dbReference type="KEGG" id="mbrn:26244195"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="268"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI63894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="33345" checksum="ACDC740E03BF29F4" modified="2021-02-10" version="1">MYRYAPQPPPSPPMEETKCSLPSISKLLGIADAGSPTSIASPDSTSESPLTEDRAVPRRQETPFSNHESCINSSYAQHLSQSKGFPPTPPLGSDASFDNHSSPITKPQRHFSIGTFSGGKYLEATPPPMESDARRFSLPQQSVTGTQGHPQHAIPQQNLPLGAFHSLSTVGGYYHSALPSGAAPHPQISNLYYQQPLPQTFPPMTLPIAYTPSSGSNPWQHHHYLNPVHGMSYTQSQDRYICPTCSKAFSRPSSLRIHSHSHTGEKPFKCPHAGCGKAFSVRSNMKRHERGCHSFNINSGRQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ01</accession>
    <name>A0A7D5UQ01_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ubiG</name>
        <name evidence="2" type="ORF">G6M90_00g017270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548803.1">
        <property type="nucleotide sequence ID" value="XM_014693317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ01"/>
    <dbReference type="GeneID" id="26238247"/>
    <dbReference type="KEGG" id="mbrn:26238247"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="55"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="276" mass="30720" checksum="D7FAF9688913F0D8" modified="2021-02-10" version="1">MASNPEKQRGIHGSWIENAEWWDTTMGLDGNKYWQELQKPSLERLVPVQPGGRALDLATGNGLVARWLAGKGACVTASDGSEEMIKHAARRSSPDEADRISYRVLDVTLPEAFEDLVKSESAEGGFDIVTCNMALMDISDLEPLADALPKLLKRGGIFFATLLHPVFFTSGATRFVEVVTDEATGEYCNARGKIVREYRDKAPWRGVAVNGQPAFQLYFHRPLDVLLGTFFKTGLVMDSLEELYFDEADAIKERPESSANYTQIPAIMALRFRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQD7</accession>
    <name>A0A7D5UQD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DBP10</name>
        <name evidence="19" type="ORF">G6M90_00g022380</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548316.1">
        <property type="nucleotide sequence ID" value="XM_014692830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQD7"/>
    <dbReference type="GeneID" id="26237760"/>
    <dbReference type="KEGG" id="mbrn:26237760"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="114"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="334"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="613"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="730"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="797"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="824"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="881"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI64173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="892" mass="99230" checksum="26C12B00725A12F6" modified="2021-02-10" version="1">MPRRAASPAASEPELDILDSLYPGEDADSNQNFPADRDVDLDDILNDPEGAEDGGDEAFIALQQAASYRKASNLKGRTVKKGGGFQAMGLNSNLLKAIARKGFSVPTPIQRKTIPLVLDRKDVVGMARTGSGKTGAFVIPMIEKLRAHSGRFGSRALILSPSRELAIQTLKVVKEFARGTDLKAILLVGGDSLEEQFGYMAANPDIVIATPGRFLHLKVEMSLDLSSIKYIVFDEADRLFEMGFATQLTEILHALPPSRQTLLFSATLPASLVEFARAGLQDPSLVRLDAETKVSPDLESAFFSVKGAEKEGALLHILHDVIKMPMGTPEIAKQDSEKASKKRKRGESGSGKPTEHSTIIFTATKHHVEYLANVLQRAGFAVSHVYGSLDQTARRNQVEDFRRGRTNILVVTDVAARGIDIPVLANVINYDFPSQPKIFVHRVGRTARAGQRGWSYSLVRDSDAPYLLDLQLFLGRRLVLGQEGEEPSFASDVVLGSLKRDLVESNVEWMNKLLHEDVDVSTLRGVAAKAEKLYLKTRNSASSQSAKRSREMVSSTGWNQLHRLFGDDVDNMEQARADMLARISSFKPQETIFEISHTDKSHSEAAEVMKQLRKKITPRNRQAQKQESDIEDDDIPTKSNDNKVDMDSDQEASDNGSQGADQTNGWDEDELEVTVSNTDSKRGKTDWRDSEVFMSYTPRTHNAVEERGYGVHSGGFVEAARDAAMDLTNDETAKSFGQPSRSKMRWDTKSKKYVSRDNDEDGSKGSKMITGESGVKIAATFQSGRYDRWKKAQRIRSLPRVGEAEKPGTTQGLPSGVRYKHKLDKAPKEADKYRDDFMVRKKRVDEAREKRQGRFRDGMGSKKELKGANDIRKERQEKERKRAKNARPSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQU1</accession>
    <name>A0A7D5UQU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g018830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548657.1">
        <property type="nucleotide sequence ID" value="XM_014693171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQU1"/>
    <dbReference type="GeneID" id="26238101"/>
    <dbReference type="KEGG" id="mbrn:26238101"/>
    <dbReference type="OrthoDB" id="5310497at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029004849" description="Cell surface protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="31542" checksum="5BF1323437E393F9" modified="2021-02-10" version="1">MRYALVSAALAATASAHGLVTRIQGANGVMMPGLSVADGTPRDCSSNGCGSQADTAIIRQRDIRSGRASPLGRTQGNGPIDASVMVSSFMGGANTAKAPTNNGASGAAGQEDDLSALQQQRQQRREEEKRQLGQLLGGGKANGGGGLLGGLLGGGAGAGKQTNAAPESMVADTAGQGSSQGLPTADENGEVTMVFRQINQDGAGPLSASIDATSGGTKAESFQNAEVTQDVPGLGFGGLSTATKTDFPLKVKMPAGMTCEAKVGGAENVCIVRVQNTAAAGPFGGSAAFTQTKTARARAIAYRLKKRMEINRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQX8</accession>
    <name>A0A7D5UQX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FBP26</name>
        <name evidence="7" type="ORF">G6M90_00g008400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985794.1">
        <property type="nucleotide sequence ID" value="XM_066129648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQX8"/>
    <dbReference type="GeneID" id="26239111"/>
    <dbReference type="KEGG" id="mbrn:26239111"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="435" mass="50060" checksum="B8A253DDC1343105" modified="2021-02-10" version="1">MAGPGAMYLKFGPDIILCLCPLRVQNKDAQRYLQWLSIPAQTFNVGNYRRNDAPQPTADFFDTNNAEGERKRRAAAEAAVADMLAWFRTGGVVAILDATNSTKERRKWVSDVCAQHGIEVLFVESKCDDQEIIMANIRDVKTTSPDYRGQDPEAAAQDFLNRISNYEKSYKTIDQDGDEDEYTYLKIMNIGKQVIINRIQDYLQSRIVYYLMNLHIRPRSVWLSRHGESMYNLDGRIGGDTLLSPRGEQYARKLPELVRESVGDDRPLTVWTSTLKRTIATARFLPLHYNQLQWKALDELDSGVCDGLTYQEIKDRFPEDFAARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSEDILIVTHQAVLRCIYAYFMKKDQAKSPWMNVPLHTLIKLTPRAYGTEEVRYEANIPAVSTWRGKGSTAKHENPTPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQZ1</accession>
    <name>A0A7D5UQZ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding motif protein, X-linked 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Rbmx2</name>
        <name evidence="5" type="ORF">G6M90_00g002190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542862.1">
        <property type="nucleotide sequence ID" value="XM_014687376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQZ1"/>
    <dbReference type="GeneID" id="26244235"/>
    <dbReference type="KEGG" id="mbrn:26244235"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="311" mass="38157" checksum="ABEFC485BE531B4B" modified="2021-02-10" version="1">MNKIRAIQELNRREIENGITPEGSWHVDYRDTAFIYFGGLPYDLTEGDIITIFSQFGEPVFLKLARDKETGKSKGFGWLKYEDQRSTDLAVDNLGGADISGRMISVDHARYKPRDDEDPEEFNVSWEAMMRREGKLKDEDEESEEEEVARPMLPEERELAILMRDHDDDDPMKGFLVEEKKREVEEARSKADRKERHGDKHRRRHRRRDESPEERDKRHRERSRERESKRPRDDSRDRERRRRRDHDEDRDKRRSRRDRDDDDDEREWRRDRERDRPKHDRNRSQERTERHRDDEKRRRRSRSRSPRRHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR44</accession>
    <name>A0A7D5UR44_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g027150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547872.1">
        <property type="nucleotide sequence ID" value="XM_014692386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR44"/>
    <dbReference type="GeneID" id="26237316"/>
    <dbReference type="KEGG" id="mbrn:26237316"/>
    <dbReference type="OrthoDB" id="3250044at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="298" mass="34155" checksum="802638F8EC38A42F" modified="2021-02-10" version="1">MQNTSGPNIAAHAVSRSRGKRPGESLYRVKLRERRIANGQARSSDESETDEEHEPDAVILHQLFHRKVVHRSDGVVVKSGKRLALGEAEAMRVARMAGLPVPLVHRAKTFPDGKSEIHMDYVQGESLDKLWPAMSVEEKKDVCRQLREILEQMRSIAPPCELIGACDGTEIRDTRVLNTYHHPPCRDEEMFNGFLLSSLFKITPEAVREALSLHLRTDHRIVLSHCDLAPRNILVQDGKITGLVDWEDGGWYPEYWDYVKFFQRPATTDWKQYAKDIFPKLYHDELVAYTAISRWQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR79</accession>
    <name>A0A7D5UR79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RPR8</name>
        <name evidence="11" type="ORF">G6M90_00g023820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985804.1">
        <property type="nucleotide sequence ID" value="XM_066129909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR79"/>
    <dbReference type="GeneID" id="90967499"/>
    <dbReference type="KEGG" id="mbrn:90967499"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="495" mass="54300" checksum="AFFCDD871601C990" modified="2021-02-10" version="1">MFAVPGWSVSADALKPETASASGPSGVKSKKRKRNNVESQSITSTNVADLYEAVVEGKGKLPPSNQGSKDDNNSAKRAKKQSMTTKAAAQDDQPKSSKKDKKTKNKNRDQNTTTANDARLPEPLDNTSSTKPSKPNTTSTPSAAAPSKLTPLQASMREKLISARFRHLNETLYTRPSEESFTLFQDSPDMFTEYHEGFRRQVKVWPENPVDSFLSDIRSRARAKPPTKGRPGPPPSQRNKMALPRTTGTCTIADLGCGDARLAESLQGDRSKLRLDIKSFDLQSPSALVTRADIANLPLEDGSVNVAIFCLALMGTNWIDFVEEAYRILHWKGELWVAEIKSRFGPARKSAVVEHSVGNRKKNSAALGKKAKAARDAEADALHGEDLAVEVDGLEDKRRETDVTAFIEALKKRGFVLQGERAEAVDLSNRMFVKMHFIKGASPTKGKGVKAEDASKMGAAHKKRKGFAPKWDDDEHAENAEDEASILKPCVYKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URT3</accession>
    <name>A0A7D5URT3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat and KH domain-containing protein mask</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mask_0</name>
        <name evidence="5" type="ORF">G6M90_00g001380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985940.1">
        <property type="nucleotide sequence ID" value="XM_066129506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URT3"/>
    <dbReference type="GeneID" id="26244307"/>
    <dbReference type="KEGG" id="mbrn:26244307"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="208"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="762"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="795"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="861"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="894"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="927"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="960"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116354" checksum="1096F8ADC5F3BBE0" modified="2021-02-10" version="1">MGKVIAASTAASLRSSFPNLELAVVLTGICGGVPHAEANGIVLGDVILARRVVQYDLGREYHDGFVAKTTVDEGLAEKHNLVAFEMEGAGVWDEIPCIIVKSVCDYADSHKNKQWQNYAAATAAAATKALLERYPRTDRTRFALVERGDAQLLTGDNQVNACRDALSLREPVVDLETLKSRKGQRTKGTCKWVKDNEKYQSWLGGDSQFLWISGGPGKGKTMLSIFLTEELEKHTQKSKDTELLFYFCDHQDENRNSAVAVLRSLVCQLLSKRPHLMKSISKYFESSQKTQTTVSSAQALWVVFQTLLQANLGTVLCVIDGLDECDGESTGMLVGKFCDFFPPDKSNKMLKLAIVSRKLKGLEAFCQVNLDHDDEGHVSDDITNFISAKVEELDKVEDFGCIREQVETTLRHGANGTFLWVSLVIMELLKKTTCTEILDSLEEFPPGLDAMYGRMLQKMKNSLGLVASKILRWVVMATRPLTLSELAKAVQVGPLASLSAEKVMSDYITLCEPMLRVLKVGEDKEIVDLVHQSARDYLLRPMMSGNYEAPEEFLINTGEAHFELLEVCLDCIEGSDLRNGPVSDALDLQKSPLLDYALEWWPEHARHSSAYGEKHLDLSRPMFRKQSNLRTYWWVSYWWTLETPMPIDFMPSGRLPNLPLLHLASCFGIEWLARKILSGRRFSILSRVLKKEEDDLGNTPLLYAIDRGHEPLVQLLLEKGSKVNVKSSNSQKPLIRAVDCGNGTILKLLLAKKGNVDEKDEESRTALLRAAFFGYDTKAKLLIEHGADVNAVDEHGNTALIFAANGGHHVIVKPLIEHGANVNAADEEGLTALICAASYGHEVTAKLLVEKGANVNAANNKGNTALIYAADRGHNVIVKLLIEKGANMNTANNKGHTALIYAAINGHEVITTLLIEKGANINASNKYGGTALIYAANYGHNVIAKLLIEKGANMNTANNKGNTALICAARDGQDTFVELLLKNGACINAKNDYGRTALMHAVANGHDTTVKLLLANGADVNVQDQVSRDLALHLAAEYGHENIVELLKASLSQYTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URY3</accession>
    <name>A0A7D5URY3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter prlL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prlL_0</name>
        <name evidence="9" type="ORF">G6M90_00g026170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547966.1">
        <property type="nucleotide sequence ID" value="XM_014692480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URY3"/>
    <dbReference type="GeneID" id="26237410"/>
    <dbReference type="KEGG" id="mbrn:26237410"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="485" mass="52627" checksum="6B6F897DBC34779B" modified="2021-02-10" version="1">MAEGDEKHGIGSDDAEIGVATPVPNEEPPIDGKLEKRLLLKQDLRILPLCASIYFLSFLDRSNIGNAKILNSSTHDDLQTSTGMTDYQFNIALMVFVVAYAVFEVPSNILLKRLRPSRWLAFLMFCWGALTICLSAGRNFGGVTALRFLLGAFEAGLFPGLVYYLTFWYRHNERSVRVAFILASATLAGAFGGAIAYGIGHINKAHNLRGWQWLFIIEGIPSCVCAVLVFFLLPDYPETASWLGEAERDLAQRRLLHEGSKGTQPAMTWADAKATLTDWRLYGHYAIYFAISPGFASLSLFSPSIVSGLGYQDLQAQLFTVTPWAVAYVCQLAVAYSADRFNARGLHTAGAAAVAAVGFIVSAALPPTAYASRYGGLILATSGAFSAIPPLLGWLSSNMYSTAATGLAIAINVSCGGGLGQIPGVWIYKAGEKSRGYPTGHWTNAGFQIFVAAASVGLWAFYRVKNRRLTEEARRNGVEPTLFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US19</accession>
    <name>A0A7D5US19_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPL17</name>
        <name evidence="10" type="ORF">G6M90_00g014340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549088.1">
        <property type="nucleotide sequence ID" value="XM_014693602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US19"/>
    <dbReference type="GeneID" id="26238532"/>
    <dbReference type="KEGG" id="mbrn:26238532"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="62"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="336" mass="37543" checksum="0E42D84221B2536F" modified="2021-02-10" version="1">MTASSRGRRALQGALSASPNVCSRCATSTRIATRFYSSTTAATTNLSPDAAAPPPTRATPPYDVRSGLILTRPPLLTRKLHPFENAFFFYQKRLEERLNTPFITSIYFKPDTARRLDWSLKVGERQGTVAKDIGVYNGKGSMAWDDELKVGDQLSSQDSVLNSLLKDAEARVSDDAEVIAAEDVVPVERPVERETEADKKGDVKRLDRQLERTLYLVVKGKDGWMFPADVVSRDENLHEAAQRVLDQAAGVNMNTWIVGRVPVAHVVKQPVQTADGTVQTRGQKTFFLKGRIMAGQADLKGNPFGYTDFKWLTREELEKELSPEYFRGVRNMMSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US77</accession>
    <name>A0A7D5US77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g009960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549520.1">
        <property type="nucleotide sequence ID" value="XM_014694034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US77"/>
    <dbReference type="GeneID" id="26238964"/>
    <dbReference type="KEGG" id="mbrn:26238964"/>
    <dbReference type="OrthoDB" id="4938920at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028999934" evidence="2">
        <location>
            <begin position="19"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="209" mass="22644" checksum="A798E730B03E8023" modified="2021-02-10" version="1">MRFAVFVAVTSAIALTDAAPVVQTEAAVPDVPHRDPADYYKVVAAQPTETASIPPHKKYRGVPQTTEGITVQNSKRWLIFGDPTLNRNKTEPVRPQLPKTSASTNRFPRPMLPLIPCCGPCETFFEKNPAGLGVFVCPSMPSRKPSPTTTEGQGPKETGKPSSTVTEGRGTRVTEMPSSTITLEQGPKITKRPSPTKAHGHEENKMSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USA2</accession>
    <name>A0A7D5USA2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">qa-y_2</name>
        <name evidence="11" type="ORF">G6M90_00g025760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548007.1">
        <property type="nucleotide sequence ID" value="XM_014692521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USA2"/>
    <dbReference type="GeneID" id="26237451"/>
    <dbReference type="KEGG" id="mbrn:26237451"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="13"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="522" mass="58318" checksum="900E6CD6F621A3D4" modified="2021-02-10" version="1">MRWLSPNLFYAFTVVVIAFGSIPKGYDEGGFASASGLRSFLTDFGLTRGRWTGDPSQLATRRAVVSSLGVLGAAIGAGMAIYVTDVIGRLRTWQLFTLLWMTGFFTVTFASGNVGVLLFARIWGGIGAGGLTVVAPLYLSEIAKAKNRGMIVSVYMVVLLTTLMLGFFISYAARRTMASNREQYRVVLAVPQIPVGIALFCSLFLHDTPRWLASKNRHDEALIVLARLRNKSMEDPEIQSEYREMQQEVVSKNLILADTSTWTIIKEVATVPSYRNRFLLGLAMQTFAQWSGGNGITYYIPEIFRLAGITTNRALINAGGYGATKLVFTMVFTWGLIDYFGRRRCFMTGLAMQCATHIYMAIYMAIWRRSDNQSASTAAIASVFVYAIGWSIGLCTVQYLYGTEILPTRVRGVCYSVNMMVHWLFQFAVVRTTPPMFRNLDVWGAYVFWALVCFIGLIVLGIWAPETKGVPLERMGELFEGPWYKTWKAKVNMNGDGESLHLQTSRDSVVHQHENRNKAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USG2</accession>
    <name>A0A7D5USG2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspercryptin biosynthesis cluster-specific transcription regulator atnN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atnN_1</name>
        <name evidence="7" type="ORF">G6M90_00g009710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014694057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USG2"/>
    <dbReference type="GeneID" id="26238987"/>
    <dbReference type="KEGG" id="mbrn:26238987"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="480" mass="53937" checksum="94BE9B1CE74F81FC" modified="2021-02-10" version="1">MAPKVRTGCKTCKIKCDEGRPACERCCKTGRICDGYDGPPATGVTTPSLTLTRIASSSGTTQEVRALRFFVERTAVQFGTFAPDDLWSSRVLQLAHSNTCIRHALVALSSYHERYWSHDVGGETPYGLRQYNLAITELVKSGADRPSYLHIQLVSCTIFICIEILRRNISNAMYLFKYGCRMIEGAMKQVRKGGYVGGATGISIEPIIRLVEAFFARISTQVFLAIGGDIDHKLADIISPMLKLRMVTMTPKPTLSSIQEARDSLLKLALQYRRDMTMAQSKALGIRFDAWTEAFDEFRRAVDRNSLNSTDKRALALLELHRRYLYINIAALNQPDREDPSMWDLWTDQFREMVEFATEAGGLDAADVPADNQPQFYMEVGILPALFFLSSKCRDPEVRRRAIDIMETNHIQEGIWNSKMAAKVAKRVIALEEGEFIVKSSTDIDGLARVRRVAVHAGPEVAYLNVGYELHCGWVQEELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USJ7</accession>
    <name>A0A7D5USJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g000420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543024.1">
        <property type="nucleotide sequence ID" value="XM_014687538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USJ7"/>
    <dbReference type="GeneID" id="26244397"/>
    <dbReference type="KEGG" id="mbrn:26244397"/>
    <dbReference type="OrthoDB" id="4947802at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028818874" evidence="1">
        <location>
            <begin position="24"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="414" mass="44532" checksum="84AFF2EF2A1EB172" modified="2021-02-10" version="1">MRLSQLLSITLTSASMVGTLVSAARLPPMAGSNNGDVLGKRQLSAAGLPDLSDEQQAELLKVYKAYSSAKDIKSFLDGVSNLPKGEAFKTLAKALGGGATAGNVRSALDKTPGKPQTVIITYVLGIGKCLVEGKSVTDAVDCGKKAVIGLGDLAVIKVPETCNNRLGQLELFGTGWPAPCHDPKAIEHPQGSAAHRRLKWGFCRLFEIMTPERLRKTDQQTGGSCDSRFPTDQQIKDDLCRKYFGGAPCGASFPLETEEDFKKAKADEAKYKKWLESFSPQLQFEAVVGVQGEMPSMFKGKNAVPLDKETCRGGKCGETCSGDKCLPLREVCEPACVSDEAEGGKCNCGWDQFGMKCNSCHVDKCDECVLKPITEKDGKFFAGEQPEQLHVECRDNGECYFVPTRPSTAPAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTB7</accession>
    <name>A0A7D5UTB7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g019960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548547.1">
        <property type="nucleotide sequence ID" value="XM_014693061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTB7"/>
    <dbReference type="GeneID" id="26237991"/>
    <dbReference type="KEGG" id="mbrn:26237991"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="zf-C2H2"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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            <end position="281"/>
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            <begin position="191"/>
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    <sequence length="366" mass="41790" checksum="5EF6E7C9DA181809" modified="2021-02-10" version="1">MSIIREDGRWYCKPCNRVFATWEAIFKHKEYMRGTGAESHIHCKFCGQDFKTQAAEISHIIQNHPKRQKLDCPGCGQGPFPRLASLIWHIERGECIRIDEAVLDEMREKKLEFPRQLETLTKESVKNNYTSYVSPKQGGSPRHIWRDVRDQGFSFTEMGFPELSNEARHTTGETPKSDKDEFHQSEAKAAWGGGKDLFPGAPPAQMPTRSQLDTATTPSPRMIFESMDADDPDNPAFNASRYYSDIIEQYICPKVRCGKCFKRQGQLVSHLRSPAHGNRTYRCPYCQKVFKTLTAITSHVESSSVKCQIREADNYEAYLDQLTAGIIDVEERRNEDGTLQYKTAESARAAFRGPKDTSKDHGQVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTL1</accession>
    <name>A0A7D5UTL1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor protein SRP40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="89"/>
            <end position="553"/>
        </location>
    </feature>
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            <end position="105"/>
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            <end position="176"/>
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        </location>
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            <end position="300"/>
        </location>
    </feature>
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            <end position="321"/>
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        </location>
    </feature>
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            <end position="425"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI66556.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="61515" checksum="0890829819531157" modified="2021-02-10" version="1">MAPELSPTKSDKVSKALVPDENGYTRLHITPLDQELVKIVIPASVLPSARNISFHTLETFPEKRYGFVDLPQMEAEKLKRKLHGATLKGSKMRIEKARPEDRVEPTGDVDTEIKSKKRKSKDESESSKRRKRDHKVVEGVVLEDRKVKRGWTESADTKRKNKKTKDKSTKDKDQEKRRRQKSKYTDQDECLLKTKLPPNAVGNLPAADAHKKKKKKGNVREVTVHEFEKTTKFPSFLKNTAPETNGKPATEFVEGKGWVDEDGNVVEVVKKQDLPVTTPKRKASSKKEAAVQEESDDDDTSGSGTSSEEEEDGDSDPDESEAVNVTKVEAEEKDSGSSSEGDDTSSDDSSSEEEEDPASSPTNKADNTRPMSSSSSRSLKIKIPPPPTTPSASKVHPLEALYKRAKPSETAATQTAAQESQPFSFFGGGDADDDDIEDEPAAPSIPMTPYTRQDFEWRNVRSAAPTPDTAHPSRTSFPQADDVDMDDAAEEEEDEDQDGEEGAPARGQSGSSDFQTWFWENRRDLNKSWMDRRKGAAKEKRHRENKARASKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTV1</accession>
    <name>A0A7D5UTV1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">gsa1</name>
        <name evidence="15" type="ORF">G6M90_00g014730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549050.1">
        <property type="nucleotide sequence ID" value="XM_014693564.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26238494"/>
    <dbReference type="KEGG" id="mbrn:26238494"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="214"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="223"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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            <name>Mg(2+)</name>
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        <ligand>
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        <location>
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        <ligand>
            <name>ATP</name>
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            <begin position="490"/>
            <end position="491"/>
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        <ligand>
            <name>substrate</name>
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            <dbReference type="ARBA" id="ARBA00004965"/>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI65792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="503" mass="55309" checksum="BE2BD6AF21559D5B" modified="2021-02-10" version="1">MTSGHDAEPSRQYPPATTPEELDHLVEVIKDWAIGNGLAVRTPPAVISSEADPTRITAVPAPVTLFPTAFPRQAFLQGQKAQNAYNELVIDGDDFVRDLWAVHETVKSEGYTQPLSLGLFRSDYMVHEHKSSESPTAQAKQVEFNTIAASFGGLSVHASRLHNFLAKTEYPLLGQPLAQGTLDLPANNTIEGLAGGIEAAYHAYGDSELGHDKCVIFLVQGGERNVFDQRHLEYQISKSSPTIPVFRLAFTDIMKHTSIAKSPKRQLLYTLPRNGNRVFEVAVVYMRGGYGPDDYPNQQTWDARCHLERSHAIKCPTVLTQVAGIKKVQQVLATPRPSSEPSILSKFIKDDTPSAIALWNTFTNIYPMDTSDVGLEARKKALDPEQCVDYVLKPQREGGGNNIYGSAIPGFLKTVPEAHWNSYILMELIKAPAENNFILRNGAIEKGRVISELGVYGTCLWNQETGEVIRNEQAGWLLRTKGEESQEGGVAAGYGCMDSVSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTZ2</accession>
    <name>A0A7D5UTZ2_9HYPO</name>
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        <submittedName>
            <fullName evidence="4">Dynamin-related protein 4C</fullName>
        </submittedName>
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        <name evidence="4" type="primary">DRP4C</name>
        <name evidence="4" type="ORF">G6M90_00g035330</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynamin, middle domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF131">
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    </dbReference>
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            <end position="461"/>
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            <end position="947"/>
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            <begin position="1"/>
            <end position="11"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
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        </source>
    </evidence>
    <sequence length="947" mass="106939" checksum="BEB15DF2086320B4" modified="2021-02-10" version="1">MTTATPRRHRGGGGSRRIKQDPDTSLTEPFALDDINDVDVRSYVTNYGPTNHIARQGRSDAPAPSERSLDTGPMLREIRTRPNATNGVSVESPISNHDDSFFHTSFQDIGKKLKACNDTLGELQQLGVSHDVQLPELVLVGDQSAGKSSLMSGLANLDLPRSEGTCTRCPLHIRVSRNSDWSCRVWLRKEYSFQPPTDRPIVESDVTDEDPFFPWRKQPVSAVHEFKTMQDKSQIEEVLRWAQIAILNDDKHHGLFIPGSGAIAVNRRIEDAAAETVAKFSPNVVALEIKGPDLPDLSFYDMPGIFQNPADAKDDYLVNVVRNLSKAYIQHPSAIIICSMPMNSDAENSSTFGLTRKLGATSRTIGVLTKADLLPEAGNHDQWLAIMKGCTHQTGLGYFITSRPQGKDLDELKKWEELVFESHSLGNWPSEFHGFSERCGVEKLKSFLSERLGEEFAKSLPNIKQKVKHHLDKITKQLANLPELPDNVELEIKTGLMAFADSARLKLEGFMSHFSVLPRNFRNCLLETKPKFTLKDKSDFPVLEISDDESDAASVATTTPTAKRRTAPTNITPSKRPRLETPLHGTPSNGHVKPEEQHGLTLRGTSIMAPRATIPKKTVLPEPFAGFTNVGRGFRTLRQVREEIEAKTKAGMPDRTSDQVYEDLVVEAVRPWNGPMDAFIKQTMRELQSELESTLNKALEGLKKRFIYLEAKRHLRRFLEEHRKETEHDLALLYHDEKERLLTFNDKTFEQYRDDEYMELTRFRHFMRLKAVGPDPGNYISSDKLTEDKRVQEAKRRDQEMLRLGRDPFARELEVIAYVRGYYRLAALRFADAVSQRIICRMIPAIRRQLPHYLEDKLGIRGPDAASVYERLMEEDETTAGRRETLKSEKDKFVRALASIELLENGAAAAANMSMSSMAGVSMTETETATQRVEPMELDSRTEEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU04</accession>
    <name>A0A7D5UU04_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g044050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="GeneID" id="26240303"/>
    <dbReference type="KEGG" id="mbrn:26240303"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="261" mass="28586" checksum="EA7D282F2747CBCD" modified="2021-02-10" version="1">MASAAHCLMCFEALDAHLEDREPLSLSEIESSWALYTSSVSDSEPGPSRNDQAPKTPALRRLAADADSSASSSSASPAWSSSTPATSMSSLSLGTSSAPLFVTWNTVSGDDVSLRGCIGTFESQPLGVGLPEYATISALHDTRFSPIVKEELPELQAAVTLLTDFEEADDAYDWEVGTHGIRLSFTDRGHRYGATYLPDVASEQGWTQDETLYSLIRKAGWMGGRSRWKSLELKVTRYQGKKASLNYPEYKKWKDWVVSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU67</accession>
    <name>A0A7D5UU67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-canonical non-ribosomal peptide synthetase FUB8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FUB8_0</name>
        <name evidence="5" type="ORF">G6M90_00g029760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986063.1">
        <property type="nucleotide sequence ID" value="XM_066130040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU67"/>
    <dbReference type="GeneID" id="26245831"/>
    <dbReference type="KEGG" id="mbrn:26245831"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="592"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1104" mass="120241" checksum="0FAD0D62FED9C6B1" modified="2021-02-10" version="1">MSDSIDWQTNRLQILPMLIVVFPLQLQFNFSATPIRSPYTLIAMATKHERIAQHNHLVPHAVDRLAHMMPDAEYGEWVLGSKVISITYAQLANIVNGLAWWLVKELNGSGYNKPQRETLTYIGPNDVRYSALVLAAVKAGFVIFVTSPRNSQPAQRALFNHLGCQTLITTNPLSPPAQAVLDAVAPARHLTVPSVEELLSSSHPTYVWNKTFEEVQNDPFVVMHTSGTTGLPKPIIWTHETCARVVNAKNDREPKGNSSVERLLLNGKRIIVTLPPFHGALLAQLVVGAIPYGNVVIAPVVTAIPTAQNVVDALKQTPADVAILVPSVVAELAQNPELLEYCSTHLQAILYIGGDLPQDLGDIVASKMYLRCQWGATETGIVPQLLPPELLPSASTGRELWSYVKFHPCVGAAFDEVADDLLDKEYRTRDLFEKHPHISGIWRWRARADDIIVFLNGEKTNPISMEQHILAKNPQVSGALVIGSNRFQAALLVEPASEKPLTIAEQAALIEHIWPSVDEANQSAPAHARVEKSFILVIPADRRLIQSGKGTYMRGPSIAQYSEEIESLYAAADDAVLGDDINGSDGPVPHALGLDGIVRLVRQHAQAVTGWTNLGDADDFFDRGMDSLQGLRLTRALGRSLYRPDLALSTVYQNPSISRLAESILAKGNGDQNEGKVMEMLLATYRGLIQQVSVSPALANSRQRQKEKAGVDVLFTGSTGTVGTYLLHNLLTRHEINHIFCLNRAEDGGQAAQSKSFAAAGFMETRLDNGRVTFIKANLQQPQLGLDEATYEHLRAQVGLIIHAAWPVNFNLPLLAFRPQLAGIVNLFTFAAATTAARFVFVSSVAAVEGHTTGPAPERVLNGLDTPAAFGYGRAKFLGELLMDAGARHFGNHISATVIRIGQVAGAVQRPGQWNPREWLPSMVISSLYLGQVPNSLGSHFDEVDFVPVDLLADVFVDLAIATEAQQEATSSARVFNVRNAHPTPWRTLLPAITSAAAAHHLTMNVVPPATWIAALRASGDSDQVDNKATSRNPAVKLLDFFSTLWAAELGDLDTNSAPASSAVQPMAIAQALEASPALRKLGPVSSEWMRKWVDEWIVAIREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU71</accession>
    <name>A0A7D5UU71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986184.1">
        <property type="nucleotide sequence ID" value="XM_066130487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU71"/>
    <dbReference type="GeneID" id="90967749"/>
    <dbReference type="KEGG" id="mbrn:90967749"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="119" mass="12893" checksum="DEE008F8CBA05F20" modified="2021-02-10" version="1">MIKISSLSSSLAIQLVSCTTGSVTRLILIFIKARQGQNRRLSFPCSIVQSSSTYTAQALVCVPQTAIIGGGIIGLPKRYEELGVQFMTDSELACAHREPHSNNDELSAVDIHVHQPAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU93</accession>
    <name>A0A7D5UU93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">nuo-51</name>
        <name evidence="17" type="ORF">G6M90_00g036330</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547025.1">
        <property type="nucleotide sequence ID" value="XM_014691539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU93"/>
    <dbReference type="GeneID" id="26239588"/>
    <dbReference type="KEGG" id="mbrn:26239588"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI67010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="486" mass="53143" checksum="50FA4131A626D557" modified="2021-02-10" version="1">MLSSRAAPSKAVSLSRNAARGLATVQDGTPKRTYGGLKDQDRIFQNLYGRFPPDLKSAKKMGDWHKTKEIILKGHDWIINEVKASGLRGRGGAGFPSGLKWSFMNSKDWDKDTKPRYLVVNADEGEPGTCKDREIMRKDPHKLVEGCLVAGRAMNATAAYIYIRGEFVYEAAVLQNAINEAYKDGLIGKNACGSGYDFDVFIHRGGGAYVCGEETSLIESLEGKPGKPRLKPPFPAAVGLFGCPSTVANVETVAVAPTICRRGGSWFAGFGRERNQGTKLYCISGHVNNPCTVEEEMSIPLRELIDKHCGGVRGGWDNLLAIIPGGSSTPILPKNICDDQLMDFDALKDSQSGLGTAAVIVMDKSTDVVRAISRLSHFYRHESCGQCTPCREGSKWTEQIMSRFERGQGREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARMQKFAQENGGAALAGGWEANTRSQGKLVSPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUA2</accession>
    <name>A0A7D5UUA2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g042190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986198.1">
        <property type="nucleotide sequence ID" value="XM_066130293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUA2"/>
    <dbReference type="GeneID" id="90967676"/>
    <dbReference type="KEGG" id="mbrn:90967676"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24956" checksum="C39672EFCE71031A" modified="2021-02-10" version="1">MARNGVHIFLDMSNINISFQCALRGKFSIKEHARFVPLPQLNLQFLTEILVRDRKIMTLNAGCSVLPHRQEPRFVQELRDLGYRVDLRERKRENHDFKAGEASSSDEFVFSRNGGRYVEELVDETLQTRIAESVMEFFKDQGTLVIATGDARPAKYSDGFFAYAERALRMGWNVEVVSWRASLSSHWNRPNWVEQWSGRFRVIELDDYIDHLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUC0</accession>
    <name>A0A7D5UUC0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DIC1</name>
        <name evidence="12" type="ORF">G6M90_00g034250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546822.2">
        <property type="nucleotide sequence ID" value="XM_014691336.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUC0"/>
    <dbReference type="GeneID" id="26239385"/>
    <dbReference type="KEGG" id="mbrn:26239385"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="29"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="213"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="308" mass="34082" checksum="6986AC6C8E7BC95A" modified="2021-02-10" version="1">MASSAQESAPARKLTKEERAEQRKKKIGPPIRYPFWFGGSASSMAACVTHPLDLSDAPKSMSGTFVHIVKTDGPLALYSGISASLLRQLTYSTVRFGVYEEIKSRYTKSGREPTFPVLTAIAMTSGFLGGIAGNFADVLNVRMQHDAALPVNERRNYKHAIDGMARMAREEGALSWFRGWLPNSSRAAVMTAGQLATYDTFKRLLIDYTPLGDTLTTHFSASFLAGLAAATATSPIDVIKTRVMSSTQKQGILRIVGDIYKTDGLRWMFKGWVPSFLRLGPHTICTFVFLEMHRKTYRKVKGLDEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUF2</accession>
    <name>A0A7D5UUF2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0651 protein YPL107W</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YPL107W</name>
        <name evidence="3" type="ORF">G6M90_00g040170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547366.1">
        <property type="nucleotide sequence ID" value="XM_014691880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUF2"/>
    <dbReference type="GeneID" id="26239929"/>
    <dbReference type="KEGG" id="mbrn:26239929"/>
    <dbReference type="OrthoDB" id="10064411at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="249" mass="27104" checksum="CE259B81BF9BBFF2" modified="2021-02-10" version="1">MPASARTATSRLRLVPRIAAPARRSLATSTASAKDEQWPQRTPLGAYYTSILRDPIPYPFAHKPEEPPSTADPSVLPPHRRPTTATTTPPARGPEPTPPPQTAQEKARIIFGSRLLGPAEQAGRLALKQAKSTYLAGVLVPPQPEEPDNCCMSGCVNCVWERYREDMEEWTASKKEAERRLRAGGRTVGAADGGGSETSWSAPAVGGGKIAKDMWDDEVYRGVPVGIREFMKQEKRLKERHAREGTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUG1</accession>
    <name>A0A7D5UUG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hh2b</name>
        <name evidence="16" type="ORF">G6M90_00g042430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547580.1">
        <property type="nucleotide sequence ID" value="XM_014692094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUG1"/>
    <dbReference type="GeneID" id="26240143"/>
    <dbReference type="KEGG" id="mbrn:26240143"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI66793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="137" mass="14845" checksum="CAE8E36A453F6C04" modified="2021-02-10" version="1">MPPKAADKKPASKAPATASKAPEKKDAGKKTAASGEKKKRSKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV37</accession>
    <name>A0A7D5UV37_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin and WLM domain-containing metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YQ77</name>
        <name evidence="3" type="ORF">G6M90_00g030960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539643.1">
        <property type="nucleotide sequence ID" value="XM_014684157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV37"/>
    <dbReference type="GeneID" id="26247554"/>
    <dbReference type="KEGG" id="mbrn:26247554"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="130"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39963" checksum="513CF9B31A5F9F63" modified="2021-02-10" version="1">MTDAHESCASGSESGWVTITVSHRKHNYTFELAEDATVTDLFDDIAATLDIPVAHQKILVPKGPLLKSPFKQPDTPLASLQGKTLTLLGCGAAEAQAVQDMSAKVAQRNAARAAQKAKMKHHAQRRSRPRSPDDARYTFLQVRPLQGLPHPETSQKLLLRLKEDPGVRAAMRKHRFTVSLLTEMEPLAHTQATHEGTSRTLGLNRNQGEVIELRLRTDAHDGYRDYKTIRKTLCHELAHNVHGPHDRQFWDLCRQIEREVDAADWKSGGHTVGETSRYAVAGLADGEEDEHEDDGGWTGGEFVLGGAGNIGAGMSRREILAQAALERQRKEDEAERKACDAAEKGWRPCQRSQQPSDKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVA7</accession>
    <name>A0A7D5UVA7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g045810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544709.1">
        <property type="nucleotide sequence ID" value="XM_014689223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVA7"/>
    <dbReference type="GeneID" id="26242050"/>
    <dbReference type="KEGG" id="mbrn:26242050"/>
    <dbReference type="OrthoDB" id="10581344at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="195" mass="21525" checksum="02FA174CADA662E7" modified="2021-02-10" version="1">MQGLRLRLIDGTAGSTVGTYIDTEMAFGRITYSSSTDNISTLKSQVEACKLGIDENQHSLLAVPSPKTMTETYALSWLLTNNVSQYPGVLGLVVERTALTQASLFFGSPRMILEGKIDTRNKTTVSTSTMTHDSALYLVEEIADTEGYQAIFDALERLPRTWRTGPSDCRTESTGNWPCQPRFTTGKWASMSCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVE4</accession>
    <name>A0A7D5UVE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cross-pathway control protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cpc-1</name>
        <name evidence="14" type="ORF">G6M90_00g036920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Binds DNA as a dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the bZIP family. GCN4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986444.1">
        <property type="nucleotide sequence ID" value="XM_066130195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVE4"/>
    <dbReference type="GeneID" id="90967628"/>
    <dbReference type="KEGG" id="mbrn:90967628"/>
    <dbReference type="OrthoDB" id="5419235at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:amino acid biosynthetic process"/>
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        <property type="entry name" value="bZIP_GCN4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cross-pathway control protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="bZIP"/>
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        <property type="entry name" value="bZIP_2"/>
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    </dbReference>
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        <property type="entry name" value="Leucine zipper domain"/>
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    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="466"/>
        </location>
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            <end position="425"/>
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        <location>
            <begin position="444"/>
            <end position="471"/>
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            <end position="153"/>
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        <source>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50217"/>
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        <source>
            <dbReference type="EMBL" id="QLI67750.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="480" mass="51553" checksum="07187811281331C3" modified="2021-02-10" version="1">MGCAAASRTASLNTVNAKKVQINASGGLQDAVNYLFSRVPPQIVKISSQDINNIYPTQSSSRSAHLSVDLDFSTAIESNSSSSPLTTATISAQDFPVFTTDTQSTWLPNSPSALPAPSAHQLQSPVENQQDFVLFDNPQPRQVPNRSSVPLSSQRRHSYHNRRDRLVSSAVQNQRVAQLLQAIGHQSLSSVNANRFTNQFYASSAPSSSVSLSSQQNIQQHQQGSARPPVPLFNQSIGSVHQSAKMMNAADVDLDEFTAFEGGASTAFSSPAAPSVMDFGGSMSSSTSNLGTVSPQDLLVQDPFMSAPNSSALTALTSPSIYNESPDFDGYDVSPNFGSADFETSGDPWYPLFPQDSSHSGPELKLEDSPAQNSDDIDSVGPVSGSGNRKKATNSPTSSGRHSSVAGVGSRKRDKPLPPIIVEDPRDTVAMKRARNTLAARKSRERKAQRFDELEDRIAKLEAERDHWKKIALSQSGAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVL2</accession>
    <name>A0A7D5UVL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CYP8B1</name>
        <name evidence="9" type="ORF">G6M90_00g045870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
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        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
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    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450IV"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME_P450"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
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    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
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        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="545" mass="61909" checksum="08D2EB7F03962182" modified="2021-02-10" version="1">MSAEIALLVSNGWQAVQSWFQEQRSFAVWFAAIVCWASWWCWRFIITPRISTLEVKEYPYWIPVLGHGLSFIYNSQKLFNTARQHFHNTNEPLQLTLFGASVYFVSRAEDVSEIYRNARTFTFDEFYHHIFISMGTSGASVQQIFAPLPARIKDPENTQGKPVAKLAKELQIAQLQPGSGLDALERAQLAYLECHVRPDAVLESRYRYPDFLGGELPSQTGSVEMSLWHWCADLNVRASQRAFFGSALDRLDPDLPQKFLEFDDLSWKLLYKFPFFLARDTIAKRDYLRTALKAFYNLPREMRNDAEGWALDSTEDRLRAIGIPTEDIASIALILYWGANTNTRKAAFWLICHLLSNPSLIDPIRTETAGAFGPEGTITNLVHLHRHCHQLDATWNETLRLTGVAASLRTVTADTVLGGRMLRAGNPLIIPYRQLHHDKGIFGDDIMTFRPERFLNTKLKKGKRVCLEHFRPFGGGSTICPGRFITKRVVMILVALLLRRFDISMAGGSQDMPQADDWSPFLGIAGVKPGHDMRIRLTPRKAAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVM4</accession>
    <name>A0A7D5UVM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein YTP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTP1</name>
        <name evidence="6" type="ORF">G6M90_00g045090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVM4"/>
    <dbReference type="GeneID" id="26242010"/>
    <dbReference type="KEGG" id="mbrn:26242010"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028823455" evidence="3">
        <location>
            <begin position="27"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="162"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="482" mass="53224" checksum="2AFF681BACA45A4F" modified="2021-02-10" version="1">MGDPLARGTLLSFFLLITTLGKMADGHDHGDSHIPEGQTVSLEPLDTTLWIHIFINMFAYGVIFPIGMVLGITKSRWHVPTQVVGSALALLGFFLGHAHSGREFVSHNIHSVFANILQLLLIGQVVLGLYLKGHWEKGVNGKIRKLIRPCHSIIGKAMPLLSWAQMIFGGITALGFCQGEHVGQCAAHFIMGGAFIAYGVILTIILLVGQIWIQRTGRSQEFFDSAVIAAWGCVNTFTEHRWGTAWVKNDWQHTTMGIIWWCAGLAGMWLSRDRDGNPKRNFIPGFVILVTGWAMSAHPQELMVSAMTHSTFGKTLMAAGLSRIIEIAFVLKDKQSLSESGRSWNSFQYIPVFLLYAAGFLFMGATEEQMNLVAQSSMDGVSYILIMYSLAFLVFLFTNMLVHLYDRLANPDINTKDFPNGHSRASGHAAEEGQLRDAEQFELDGLMSDDEGGEGQAMLRESLDRPSIDTPSTLGKNNHGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVN3</accession>
    <name>A0A7D5UVN3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g049790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545086.1">
        <property type="nucleotide sequence ID" value="XM_014689600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVN3"/>
    <dbReference type="GeneID" id="26242427"/>
    <dbReference type="KEGG" id="mbrn:26242427"/>
    <dbReference type="OrthoDB" id="5372011at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="144" mass="16389" checksum="7058BABABEA2E01D" modified="2021-02-10" version="1">MSTTTPSRSTYHNPTGSASRTAAAAGAECTPEMRDRQARGKDPYKDSESDCDDGPERRVRLGRGVKTEPFEDKERRGFALSVLDSPESLMMYALSAGDSVPGQRLRFTAMLCGFEERRKGKEVAGRERERERDRDKERERERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVQ0</accession>
    <name>A0A7D5UVQ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g038260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547184.1">
        <property type="nucleotide sequence ID" value="XM_014691698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVQ0"/>
    <dbReference type="GeneID" id="26239747"/>
    <dbReference type="KEGG" id="mbrn:26239747"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="132"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="30841" checksum="3B4B7512C61D6315" modified="2021-02-10" version="1">MSEQAQVLPYPRYCFHLSPTANNWCLLRVSDIHALKQHAGFEGENFFFYRNLPIKWVRVVGPVVAIDEFHGRRVYTIDDSSGKCIEALINMQPPTPVNNVAELQYQPRTAAGDAANPGALHILDTPGPYGNVDVGDVVDVKGALSTFRDEKQIKIEKLLIVKSTAQEIKMWGRRSKFRHEVLDNPWILSDKEIRRCRKEAEASQAGSERKKKRLAANSEASTSTRQIKAKALAPGLSHESVKPKAKEKTNLKLDTAARVKALIRQGSAKGKYSALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVT9</accession>
    <name>A0A7D5UVT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chanoclavine-I aldehyde reductase fgaOx3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fgaOx3_0</name>
        <name evidence="3" type="ORF">G6M90_00g029960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539711.1">
        <property type="nucleotide sequence ID" value="XM_014684225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVT9"/>
    <dbReference type="GeneID" id="26247468"/>
    <dbReference type="KEGG" id="mbrn:26247468"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="376" mass="41756" checksum="382D061172F1B696" modified="2021-02-10" version="1">MSSKIFEPLRIGRITLNHRVVMAPLTRLRANDSHVPEPMSAEYYAQRASVPGTFLIAEATLISARGGGGSHAPGLYTDEQVRGWKQITDAVHAKGSYIFCQLVALGRAADPETLKRETGLEVRAPSSIAMENGGNTPECLTDNEIWNLVQDFASAAKRAMEAGFDGVEIHGANGYLVDQFLHENSNDRTDQWGGSIAKRAKFGLEVAKAVVQAVGPDRVGFRLSPWNTWQGMDATDPAPLFCYLIKHVKEIGLAYLHLIESRVLNNVDCESAGNIMPFMEEWGSAKPVLVAGGYNQDNFGQALERDYKDYNVGVVFGRYFLANPDLPFRLRHGIPLQKYNRSTFYAVMESRGYTDYSFSPEFEQNRRDNGNRAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWA2</accession>
    <name>A0A7D5UWA2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tca-8</name>
        <name evidence="10" type="ORF">G6M90_00g045240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544684.1">
        <property type="nucleotide sequence ID" value="XM_014689198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWA2"/>
    <dbReference type="GeneID" id="26242025"/>
    <dbReference type="KEGG" id="mbrn:26242025"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="332" mass="34484" checksum="8357497C6140C0F5" modified="2021-02-10" version="1">MQAIPRAAVRSAALRNVANRAYSSSSSPYSKTIENLRINGDTKVIFQGFTGKQGTFHARQAIDYGTKVVGGTNPKKAGSTHLDLPVFKNVSEAVKETGATATALFVPPPVAAAGIEEALQAEIPLVVCITEGIPQHDMVRITSMLKSQSKTRLVGPNCPGIIAPGQCKIGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTQAGLGQSLVVGIGGDPFSGTNFIDCLKVFTEDEDTDGIIMIGEIGGSAEEEAAEFLKEANTVGGGKPVVSFIAGISAPPGRRMGHAGAIVAGGKGGADSKIKALEAAGVIVERSPAGLGKALYDEFVRRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWT1</accession>
    <name>A0A7D5UWT1_9HYPO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g032490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWT1"/>
    <dbReference type="GeneID" id="26243982"/>
    <dbReference type="KEGG" id="mbrn:26243982"/>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16231" checksum="AED580812944F2C7" modified="2021-02-10" version="1">MLEQGKSSQIWKPVPIIQPSLDKVIEVQSYMTQIKPISVLGAPLLNYPVILRSSGEMSVIINGRGVVATNAGVAVMTDQSGLLTLTVLTDDILTPKFTVTDALPGSESAKSLAVDPADKINQRLCKLKHKEDLDIDLGPGQGKLLDGTKLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWZ6</accession>
    <name>A0A7D5UWZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g057040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544290.1">
        <property type="nucleotide sequence ID" value="XM_014688804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWZ6"/>
    <dbReference type="GeneID" id="26242702"/>
    <dbReference type="KEGG" id="mbrn:26242702"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="40708" checksum="822DE458B2D109DC" modified="2021-02-10" version="1">MSQFKDIMKKGWHPEKSGTGIRGSVSGLMGRNKDNKDDSSLNHVARPLTDLKDPASFAPPPRRTGSGLARAPSPVSTKRNVVAAPSKYADPRARPAELPPRRTGSGVESDEASPTRDAADRRSPPSYDEATSGGVVSKAPPRSLPPRLPPRGAAGGGEKSGHLNEGAVSRLGAAGVSVPALGIGRGGAAHSTSPSPPPASSRASPSAEASGAGKWGAQVNQLQGRFGKMATPSAASSAQEQQPSQGTSWAQKQAAFKTASAFQKDPSSVSFSDAKAAASTANNFRQRHGEQVAAGAKAANKFSQKYGIADKLGAYAGSQSTQPTQNKSEPPPLPGPSQPYTGATNDAAQAAVSGLAGKKKPPPPPPKKKPGLAAAAAPDPASAAQGDMPPPIPMSTRPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX18</accession>
    <name>A0A7D5UX18_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g046120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986574.1">
        <property type="nucleotide sequence ID" value="XM_066130406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX18"/>
    <dbReference type="GeneID" id="26242081"/>
    <dbReference type="KEGG" id="mbrn:26242081"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="118"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="586" mass="64513" checksum="17BCCBA3C4EAC463" modified="2021-02-10" version="1">MSVPPGLISAEGDPRLSVAEKPPQDVVHQPIHGNDSTITFEEFMYWAERTRADEALTNKALLDKRGPRTVKNTLRSRFSKGHQTDPATSVADVYSSDEEIITGISEREWKQASRAIRTASWGSIFYLITTDVLGPFSTPWAFAQMGYGPGVALYTVFGAMAGSGWIIWKAFLGLDSDRYPMHTYGDIYFRIFGRIPQILLNIMLGLQLLLSVCSLILSNGQSISQISQGNNGSNGNGICFVACLIIFMAAGFVLGQIRTLQRFGWIANFAVWINVAIIFICVGVVVHYPPNFKATQASFGDNFGPGPIRTFAGTPPDGFASGGTGFVASLNGLNQAVYSYGGCMTFTAFLAEMRHPMDFWKGLLCGQVFIYSLYMFFGIFVYSYQGQFAFNPVMQGLSSYGFQTATNVMNLVTGLIAAGLYGNIGLKVIYIEVFERLFKFPPLTVRKGKIMWAVTVPVYWSIAFIVAAAIPQFSYISGLIGAFFVLSFSYTFPALMALGFWIHKDAMVPEQEKFDPQTRTYNYVDTGLVRWRRGFLKRPFFNLFNLVYMLGGLATTGLGVYSSIEGLIAAFSGSSVASSFGCRSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX68</accession>
    <name>A0A7D5UX68_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and KH domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKHD1_3</name>
        <name evidence="4" type="ORF">G6M90_00g054050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540999.1">
        <property type="nucleotide sequence ID" value="XM_014685513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX68"/>
    <dbReference type="GeneID" id="26246305"/>
    <dbReference type="KEGG" id="mbrn:26246305"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="378"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="420" mass="45648" checksum="BB3FE7E6E66C50AC" modified="2021-02-10" version="1">MNSEASLGAFFSAVRKGRAVIVEGLLEKGIEPNSRDMYNQTALSLAAANGNESVAKLLVKHGATIDSEDDYSRSPLWLAAEKGHLEIVELLLENGADANSKSNSGQTLLQRAVQRSNKELVELLLDNGADIEANSSSGQTLLSLAVKKGRAGIVELLLQNGAGVELKSQSGQDLLWWAAKRGNGEIVKLLLENGAPTECEGEKHTLLQWAAKRGNEVITKLLLDNGADIEATRYMVPTPLLLAACHGHEQVVYLLLENGANTEVTNKFRLTPLLLATVRNHEAVVRLLLENGAEIPPFVESKEQPAALLLAIERGNEAIVKLLLENGADLDDPGYGSHIEATGRISYTPLSLAAKIGHKEIVKLLLRNGADIEAKGVYNDTPLRLAARYNHEEIFNLLLEKGALPLEKESDVRWIAEKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXA5</accession>
    <name>A0A7D5UXA5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g041150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547461.1">
        <property type="nucleotide sequence ID" value="XM_014691975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXA5"/>
    <dbReference type="GeneID" id="26240024"/>
    <dbReference type="KEGG" id="mbrn:26240024"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="387" mass="43517" checksum="68635BEBB65F08DF" modified="2021-02-10" version="1">MSNATGLPPDNNPAASVNSGMSKEAFYAVAWTATCLPLPFLLFRLAIRIRSFKTLFVDDALVIAAWLMLLVSTILWHTKAGTLFWQLRIVTGKAPQSPEFISQWSRLSSNIVVWNILCHTSLWAVKYSCLVFFRRILGPQAPRAKKIWCWVVGILLLAGWVSCVAIIDYKCSANDIKYIMAHCAGRSHVEYQFRTFYGNLAADIVTDLLVMSIPLWMLWHVRIQWPKKLLLAGVFSVTVFVMIAAGIRVALVRTSTTGVKHTSIDLLFIWSEVEMGVAVIVANLASFRQLFVFSRNRNPSGGKGYDATSNRHHQFQPFESSNPSLQGRNRSENDLIGLTDFQAPQIYSTSQHNPTAPDSVYVSHAIKVSSHEWTPEPQDSRRCHNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V042</accession>
    <name>A0A7D5V042_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">EFM6</name>
        <name evidence="2" type="ORF">G6M90_00g076920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545411.1">
        <property type="nucleotide sequence ID" value="XM_014689925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V042"/>
    <dbReference type="GeneID" id="26241444"/>
    <dbReference type="KEGG" id="mbrn:26241444"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="275" mass="30445" checksum="9BD23E3C6DAAF5EB" modified="2021-02-10" version="1">MSRSPSPLLDPVAVSEDLTPLPTLKQAGDARIDFDGQLAEPLAYHEDVRTGCGGQTWPAGLVLGKHMLRYHRQEMRTARILELGAGGGLVGLAVALGCGGENQLLLTDQDEMLELMQTNIRLNQVDSRAQALILNWGEPLPREVVTQKPNVIIAAECVYFEPAFPLLLDTLKDLLALNEEAVVYFCFKKRRRADMQFVKMAKKAFVVEELFDEDRPVFQRQSLFLFSFKCRPSAKSTAVRGNAGTNSNGVNGINGTDPGACCNMNNRMQRSWCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0N2</accession>
    <name>A0A7D5V0N2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Axial budding pattern protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AXL2</name>
        <name evidence="4" type="ORF">G6M90_00g076910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545412.1">
        <property type="nucleotide sequence ID" value="XM_014689926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0N2"/>
    <dbReference type="GeneID" id="26241445"/>
    <dbReference type="KEGG" id="mbrn:26241445"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028962152" evidence="3">
        <location>
            <begin position="20"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="883" mass="95264" checksum="4B4B50F6A96BAAF1" modified="2021-02-10" version="1">MPSLLAFVAVLPLTWLVSCEPTISFPFNAQLPLAARIDQFFSYSFSQYTFQSDSKITYSLGDHPSWLSLESGRRRLYGTPREGDVPSGQVVGQTVDIIATDDKGSKIMKATIVISRQPAPEVRIPLEDQMANFGNFSAPSSILSYPATKFKFTFDQNTFSSSGLNYYAVSADSSPLPAWIQFDAHSLSFTGRTPPFESLVQPPQTFDFSLVASDIVGFSASSLTFSIVVGSHKLTTDKPNITLNATRGTAVSYDGLENGIKLDGKQISPGDLTVTTKDIPSWLSYDDKTGRLQGTPKDGDHAANFTITFKDHFSDNLDVLVVINVATGLFVSTVEDMKIRPGSKLNLDLTKHFKNPADIALKVSTSPKKDWLKVDGLKLSGEVPKTSTGSFKLAIDASSKSSGLSEKEVVQVYFLALDGTTTTMTSVSSTTATTTARATATGSDIPDDRQTQPGHMSTGEILLATVIPVIFVAVLLMVLVCYFRRRRSGQGYLGSKYYRSRISPPVQSTMPADFSDPSMREAAAMGAFVHTETEVFKPAKSAFAEESSPISFHRRSSETLGGLSTSEMPQSIMVDAARTTTIRSVSNVTSEDGRQSWITIDGAPGGIAQSDRSSQSEVTFPEATRQIFPGADYTPRRDTGLEITLPTLNELPSLQPTPLLSHDSMSLFSQHYLGHQSAITSSSAALPIQDDHQYTTAPLGKWPTGSTSIVEGSEPNWVTLAKSETGRSMSEIRKPDAVAVKPSQPWNEADSLDGGKSVTTEASFASSENWRIVGRLGPTKTERSGKEIVDDGPVHPDRPGTSRGAAQQADHEPSTELASPNRWGDVPSPLASGRPAPSMSRFSKMSGVGDEATHMSGGRGLDEAPWIRDHSGKMSDGSFKVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Q8</accession>
    <name>A0A7D5V0Q8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor himD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">himD_4</name>
        <name evidence="8" type="ORF">G6M90_00g090190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541677.1">
        <property type="nucleotide sequence ID" value="XM_014686191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Q8"/>
    <dbReference type="GeneID" id="26245540"/>
    <dbReference type="KEGG" id="mbrn:26245540"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="619" mass="69797" checksum="5B5E4C6024C699FA" modified="2021-02-10" version="1">MNLDAGTGDNPARKRVATACEACRATKIRCQPSDQPGVCKKCLESKRECISRTTPRPRRPRKYASHQDQQLHQAQAAPPGPSSTFSIDFSVSTGSEIDDNFETLRDTHDVVIDRLFPEDDEEMSPFPDSGRSIQTPTSSSAQSHSIHDFHTKPSFNVASAESLLTSFHSMLTYFPFITLSEDTPIRQMAAAKPFVLLSILSSTSGSKTLQGHTLYDEEFRKVLGLKFVAGGERSLELLQGLLIYCAWYPFHLRPKNKQAFQYMRMAADMVHDLELDQQQPDLNMWSDTPNLTDDQLDRIRVYVGYFYIVSSFLATWKRGKGIEVPYTSWTARCCDLLEKYGKTQGDIVLAAQTRVTSILSQASKTLNEKYDQGEEDRRIMVAGFKFELAQMESSLAFPLSISVSLRVQVLFMKAFLDSGTLLRFPRPPPSESYKWEPCPLSNAKLHDCVYSTAAFYQEVMSLDDAALSCFTIVDWSRPILATILGIRLSFRIQECPDWDSEWARSQLKLDDYLARMSQQKSDLTPASKKVDILSASRTVMSVVREKYQKRLAAVERQGKSPARITCPMLDGSMEPYFPVWDAALNQPLMMESLGEGPDGQPVFQDLWTAMTTGWAHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0U2</accession>
    <name>A0A7D5V0U2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALTA10_1</name>
        <name evidence="8" type="ORF">G6M90_00g069830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540691.1">
        <property type="nucleotide sequence ID" value="XM_014685205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0U2"/>
    <dbReference type="GeneID" id="26246564"/>
    <dbReference type="KEGG" id="mbrn:26246564"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="493" mass="52056" checksum="4ED15256D554A61D" modified="2021-02-10" version="1">MSTIELRGVGGKPVSVNTGLFINNEFQPSVGGDVLPVENPATGDLLASVSSAQRVDVDAAVSAAQAAFRGPWKDVLPAKRGELLLQLASLMERDIDDLASLEALDAGILAGESKGLHVPQACETLRYFAGWADKITGQLLHIPQGYAYTRREPIGVCAAIVPWNAPLIITCWKLAPAIAAGNTLIIKTPEAAPLYGQKLAALVREAGFPPGVINIITGEGPVAGQALAEHLGVKKLAFTGSSIAGRQILKASADSNFKKVSLELGGKSPSIVFADADLENALFWTTLGITANNGQVCAAGSRIYVHSSVYEKFLHSFGEKIKQSSPGDPLLPESTKGPIVNKKQMSRIMGYIAHAKESGLRVIGGSENNTSQGYFVPSVAFADVPNDSRLMQEEIFGPVASIAKFETEEEVIGLANNSSYGLSAAIFTSNIHRADRVSAALESGQVTVNCWGLLNANAPFGGVKESGFGRDMGQEALEDWLVTKSVKHNILPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1P6</accession>
    <name>A0A7D5V1P6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g093190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987322.1">
        <property type="nucleotide sequence ID" value="XM_066131432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1P6"/>
    <dbReference type="GeneID" id="26245430"/>
    <dbReference type="KEGG" id="mbrn:26245430"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="633" mass="70180" checksum="3D0F20D2A6FCDDB4" modified="2021-02-10" version="1">MQGTGSQSLPRRRTFLACDACKFKKLRCDGDRPKCGRCMKVDVDCVYTLNDRDKRMAQRNSWIAQQYLNQPSRADASAPTAPRTSSSPVVIDGDAQYTPSTINSEHIPQPLLRQPACDMKPNHTSPSDPPLSESLADILATNAFDQLSNGEVGYFGSSTNHGFFWCLSGAIANLGYKASRSQAQRASPTSDMRGSRSRGLRKSLTHTTLHESIQKYPSNEELVARFFDNIGDVLPYVDEVSIMGKLHVLDEDANESCPSTQSWQALLNIVLAYALYTIDGPSPEPFYRRVINLLYGMAIHLSTVQTLQALLLLTSFEQNIRRSMASLSSHSLAVRTAYHLGLHAPPTILSACFGRPCLIGLNYVRPEIAKIVSISEISEVETRTLAINNTASFFALLTSLHELTGLALDKIYLSNIGSVRELPTDQLLSEVLNLSIRLDNWVTCNKIFGIMNAEVGFGNWVAPSEDAERLAIILSLHYHRVVLLVHGAILMRSLECLTTVGPQFLSGVTGETIVAMLRRNLVAARDTHYVICEVLQKRLGFLETNALWWICNYSAFTTCLHSFGLWVLSIHISDTRVSSIGTQEPDLEILLQAALRNLRTLGGMSMLSSKAYQRLQGLFDLLRDKGMNVQHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2N5</accession>
    <name>A0A7D5V2N5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Inner nuclear membrane protein SRC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SRC1</name>
        <name evidence="11" type="ORF">G6M90_00g102820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546066.1">
        <property type="nucleotide sequence ID" value="XM_014690580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2N5"/>
    <dbReference type="GeneID" id="26240489"/>
    <dbReference type="KEGG" id="mbrn:26240489"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="10">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="314"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="692" mass="78006" checksum="2A236BCD592EA161" modified="2021-02-10" version="1">MADADDYLQEGFDPRSVTVPRLRSILVTHNVDYPSTAKKGQLVDLVNDHVLSQAAKLRAQRAQAKRSSLGFVNAGSAEDSNAWDEHDTRSRHSSMRRSMSPRKSSSRIKTESEEPESNILRSPRKRSSRSASRQLSHFDEDDGAASVASKSARRSSRRTVTPQIKDESEEEYPTHADRSNEYLQPPEVEEDGGHDASVFTDDNPFQSGSSPPPVKTPSNRRRTLGEDMSQSVRSARRRTDGFTDRSKKSRISEISAPKLRQKNPEFALEPGEEFTAEEQLELEEAQSSGEVAPILRKSHKPARQTSVLTPLFVLFMALFGAYGAWYRQEKLAVGYCGLGRQAKPLLPPEIVVPDALLPFVEPQCEPCPANAYCYEGFNVRCIQGFIQKPHPLSFGGLVPLPPTCEPDSEQERRVQAVADKAVEELRERRAKYECGDLVDEAGQQENSPAIAEEELKHVVSKKRNKRLSDEEFDDLWEKAIGKVTTREEVEVQVETTQPSGASNLPVRKLSSTSLARLPLTCAIKRSIWLALARYRLAIGFIILLILGSLNARSRYRRHVATSAQVPALVDLVLQRIADQRELGEEDLDDPWLFLPNLRDDVLRSIHTLSERDRIWQRVRAVVEQNSNVRISQRESRSGEVGRAWEWIGPTKGEGARRRRSGRVSLVPELKEETPDSKDRVEARKWDEPRPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3B6</accession>
    <name>A0A7D5V3B6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Copper amine oxidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AO-I_4</name>
        <name evidence="2" type="ORF">G6M90_00g094680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540831.1">
        <property type="nucleotide sequence ID" value="XM_014685345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3B6"/>
    <dbReference type="GeneID" id="26246444"/>
    <dbReference type="KEGG" id="mbrn:26246444"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="1">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20691" checksum="65E88CEF6DD15AEF" modified="2021-02-10" version="1">MRLVENPDANFYTYPLSLCTEISSREDIICRPQQTSASEPQASRLTGKRFTVIIERVLSQPPAAATHHHEAVPAKGRLLGNDGHANSLQVDDALVHNHFGVWSDVAKNRVFKIVNEGKTNGVAQTPVRFKLVPCYSQLLLAYAVWVTRYHDDELFPAGRYTMRSRGGEDLASMIAKTSAWGTAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3W6</accession>
    <name>A0A7D5V3W6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isonitrile hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">inhA_4</name>
        <name evidence="2" type="ORF">G6M90_00g107440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544097.1">
        <property type="nucleotide sequence ID" value="XM_014688611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3W6"/>
    <dbReference type="GeneID" id="26243484"/>
    <dbReference type="KEGG" id="mbrn:26243484"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="69"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="235" mass="25435" checksum="AB47FBFABF4E3DD0" modified="2021-02-10" version="1">MSQPFNLTNPGRILRVGVVLLKGIVEIIDVAPVDQIHQISDRFVNPLPSSVVPDDLKPYAIKTEYHWVSEAGPGTLVNGTSGIVVSPTDSFETCPPLDIVVVPASASANASEAELDFLRKTYDESAAFITICFGMSAPLQAGILEGKTATAPRFRLDTFREMAPGTNWIDKRWARDGKLWTSGALLNGLHLMSAFIQETWGSSEQGARLVGAMAEMGAWPDGSPEYDDEEGKPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V458</accession>
    <name>A0A7D5V458_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g108790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543970.1">
        <property type="nucleotide sequence ID" value="XM_014688484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V458"/>
    <dbReference type="GeneID" id="26243357"/>
    <dbReference type="KEGG" id="mbrn:26243357"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25487" checksum="4DE3F31485FF9ECC" modified="2021-02-10" version="1">MVPLPLFKLASLFVRHISKYGANQIKAQAHDHPRFRAFAAKYGQHMHQLNMRMSVALLRDPEAERRAKERAEAPTVKTEEQHKRDEAAKSKSSPGASSSSSSSSSSSQSAKYPRFTLQNVWKRKFRPLPEGKAVDLFADAIGDAFILGVAGGLIIYESWKALQKPDVNKQRIDDLSERVEALRRREEELADAEEKQRQRFESLEEALRALKNPKTKEPLLPTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V552</accession>
    <name>A0A7D5V552_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase family 32 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g107190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987941.1">
        <property type="nucleotide sequence ID" value="XM_066131719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V552"/>
    <dbReference type="GeneID" id="90968223"/>
    <dbReference type="KEGG" id="mbrn:90968223"/>
    <dbReference type="OrthoDB" id="4956915at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17215" checksum="573ECBC82BBF71B8" modified="2021-02-10" version="1">MYILESQAYLVCYQWNPGTTKGGNCAWGMAKSKDLVTWEDCKVTIWNGTSYDSPGVFSGSIASRVVAVKRLYTCAIPAYPPWQSTGLSRTSTDEKHNQSPTRQTWVKHRNNPLLAVPLKEATATGWRDPFVIQSQSLLKLLNVRQDKNYIMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V565</accession>
    <name>A0A7D5V565_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g104530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541447.1">
        <property type="nucleotide sequence ID" value="XM_014685961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V565"/>
    <dbReference type="GeneID" id="26245697"/>
    <dbReference type="KEGG" id="mbrn:26245697"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="145"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI73092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="46915" checksum="136E0467230AFEA6" modified="2021-02-10" version="1">MSSPSASPQGSKRKRNAASLSNGAPDSVLQPSSRDASAEEGDTTAPESGRHHHRNGTTGPNPKRLRSNSGRSADVAPQNVIDPGEPSDTTEASIDIAERVGRRARRPSANGNDETMAPPPVGQLIHPAGGFKTNPPPVGRSVRVYADGVFDLFHLGHMRQLEQAKKAFPNTTLVVGVTGDDETHKRKGLTVMSAKERAESVRHCKWVDEVIEDCPWIVTAEFLQANHLDYVAHDDLPYGADEGDDIYQPIKAAGMFLVTQRTEGVSTTGIITRIVRDYEKYISRQFKRGTSRQELNVSWLKKNELDIKRHVQDLRDNIITNWTSTGQELSRELKQFWPSSRPHSPARFNSANSDGLRSPTTPGSNPNNSKEFVTGYALGLVGGVRSWMTKNRRTVASRPVSDDESEESDEAAKSPVSTKAPSLPAPTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V573</accession>
    <name>A0A7D5V573_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g102510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546096.1">
        <property type="nucleotide sequence ID" value="XM_014690610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V573"/>
    <dbReference type="GeneID" id="26240519"/>
    <dbReference type="KEGG" id="mbrn:26240519"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="580" mass="63785" checksum="4143CE46CEB3B75A" modified="2021-02-10" version="1">MGLGILEAHGHERVPGTTRYFDEPTRPQEASDNEQHLKSDPISHIILVPQPSDDPNDPLNWPIWKRDLITFTLCFAAILATALGAILASNTLVISAYFSATLSDTAALTGYYLLGAGCAAIFFVPSGRIWGKRHLFLIGIIFVIFSSAWGGATGNFPPKARDAPFGQSRDQKSHYNSLAAARAFQGIGAAPFESLLNAAVGDLYCVHQRGVRMAFTNLAVFGGAFFTPVVVGKITHTIGWQWTFYLLAIFSAVTFPAVFLFCPETAYRREAKLNIDSVVEEEKLNPSTSPPSSTAPQPVEPPRPHGFILFPKSSAMQPIGHANTPVKTFVESMSLFDGRKTHERYWVLFLRPFPLILNPAFVWGCLIQGAMIGWTIFIGVIIAVVFIGPPFFWGEEKAGYTYTAPFLGALLGFIISGLLADTTAKALTKRNNGIYEPEFRLILVIPMLIAAGIGLYGFGITSNDLLSGKYSYTVPLVFFAFEVGGMVIGSVASSLYIVDAYRDLTIEGFTLMIIFKNIFSFVLTFYAYDWVIGGGFRTVFLIVASIQMGICLLSLPLYIFGKRIRAFYTRNDLLALTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5G3</accession>
    <name>A0A7D5V5G3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA cleavage and polyadenylation specificity factor complex subunit pta1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pta1</name>
        <name evidence="6" type="ORF">G6M90_00g102550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">4556</strain>
        </source>
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            <strain evidence="2 3">4556</strain>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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            <strain evidence="2 3">4556</strain>
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</entry>
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    <name>A0A7D5YNE6_9HYPO</name>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">4556</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123306" checksum="5AAE4480B80DF823" modified="2021-02-10" version="1">MSAWMNDAVPNHNGNGFPHMNDPNSAGAMMDHSAFLANPGQFNPGQFPNQQQMAGMQNGPMRHGSPTYQNQNQTANPNQNQNQNAVYQTNPVIPSKRPRPREDSVTGSPGQNPGMQPPSRSETPQQQNFGGFQPAGGAMPQQPPGQFPHLQPNGSANASPSPIMGNQMRPGNVPQRVATASPHPFSPGPQQQFTGSQASPIPSEHGTPQPNQYMQNIPPGYNPGYAQSPSNPRPSPNPNVMAGGPAVGGQMLPQQMGQMPQHMGQMPANMYQQMQQQMQHQVPQPGQQQPPGQQQPPQQGQPRPQGMMDQQKMAAYQMRLQQQLQGNMQMQAQMQAQNMGRGMMPKQQVPGMPNGQMPQGAVRQQPRPMGNINPEQFMKNLTTLMNAKGLPLDPNPIVGDRPVNLVMLFQLVQSKGGYKPVTTGNGWGLIAQSLGLPAQIPTVPPTLRQVYERNLAKFEEAWIAQQKHRLMQQNPNMAGPGTPQKQMQPGQQMNQGQMPQLQQQQQQQQQQQQQPQQPHLQQQTPMKPGQTPVNGFSTPQPPQQQPLPQQPQLPPHVQQQQQHPHLHQQQQQQQPPPPQQQPQHPPISNAAPGHRNSMSRGVDPSTPNDFSMQSPSHARPGSVSIDGRHATPLPAVGAEQHMPRMPPKPEDYSPCARELSTHGGVDLHAANLLGAELERWEPTVPSVNELGNIDISALTRSLQCGIHGEVRLALDTLATISSSQNQAHFLHLRACDDLVEALVDCAESQVDLLVEHTTEVADEIQLTSYEDVVRGCRIERWSVRDVPAFGSIEYQLDGAVDRLICITTILRNVSFPGENNDNHIMLCEESVIKMLCSIIRYLGTRTMLLRTHANTLDFMKDIVVLLSNISSQLEIPGREQALSLLQFLLAFAPVPGPTMAGDTLNFTPYDPSIHSYLPHAVDALAKLLARDEPNRGFYKTLFTIDSSSPLANELLVRAFALTVAPLPDKAKEQLRPPTFPPLFETRKPFLMQGLLGAEIIASLVPGSEPGMARALLASGNCLAQNLVQLIQDLCFLYEKPPPSTRGGSRAVAARKDPELVYIVVVAVSLLRRLAEKARDSSGTGSAGIGDLLPQPQMLMDALMMQSSEWTKEGLLPQLTAVLNLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPA2</accession>
    <name>A0A7D5YPA2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547958.1">
        <property type="nucleotide sequence ID" value="XM_014692472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPA2"/>
    <dbReference type="GeneID" id="26237402"/>
    <dbReference type="KEGG" id="mbrn:26237402"/>
    <dbReference type="OrthoDB" id="4868522at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="127" mass="14109" checksum="599C17B6C1D4FF02" modified="2021-02-10" version="1">MAMVHPDKRYDSDSGSDDAVSMNIPYQARGSVYSSFPPPPAPAATIREKRARLQPPPRPVETIPPLPPVPVVVPQPKSPVGLGLLSPPLTALRPKRKTILERIDGWWDLGLLEKRQTLFGKHRNELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPK6</accession>
    <name>A0A7D5YPK6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g046150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544743.1">
        <property type="nucleotide sequence ID" value="XM_014689257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPK6"/>
    <dbReference type="GeneID" id="26242084"/>
    <dbReference type="KEGG" id="mbrn:26242084"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="75438" checksum="15F486FF00F05397" modified="2021-02-10" version="1">MAPRAKGPGPLQAALEAAWKGVASVHTEVSLVRISTAGTRRERLRALLSELQFLCGLLNCIFCLSLNLQAPDQEPVSGPFDYAILAGIAHVVKDIADNSATAPDDGLVTMTVNVRFYRDLVSQIATFAAYDLATLHQTLLEGRPTPPSTSTAPTVEDLVPSLEKWLDVLNSRHYDRTMLEWASERGLVRARREFDPGYQRAVTGWVKFARTNWEPIRASVKQLFAIPATNNFIQWAVEFARSSWPCVYDFDAPTAQPVVALVNDVSLGKVTPLHYASMMGLTGVVTDLLSNLQDTNLVNMTGRFGTPLYCALVGPRVMLFGCEPSSWGSLIVEMEPADAALIKELLSSGASGNASICMPNMESPIPLAHIAFVAATILEDPDVFTKAVDTTHPLQEDFTLMLISSSIFEDKAGSKPFMMARLATAAFDQAMVNAGDSLPWEGDEVCGAIWEFMYLQDLEFDTEENVSLPFISDGDFESVVRQCVIDAHAVIGEKAVYLERLVKDRRFDPNLLAREDGDEEGTILHLAVSGMNHVVLDELYLAYADFTAVDSQGRTPLMVIEHPATLEVLVKQYKVTTTAKNNDGQNIWHLAAATNDAAILSWLCENDPDKSANINVVSNAGRTPLAEALLCFAILDRGGRHKPTAAAAKTLLDEELVDTKLGTANLPMTLADITAQWGDAELVAKLIAAGVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQ08</accession>
    <name>A0A7D5YQ08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g033770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543304.1">
        <property type="nucleotide sequence ID" value="XM_014687818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQ08"/>
    <dbReference type="GeneID" id="26244105"/>
    <dbReference type="KEGG" id="mbrn:26244105"/>
    <dbReference type="OrthoDB" id="9971601at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF2">
        <property type="entry name" value="METALLO-HYDROLASE_OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39112" checksum="8E06220E0069DF86" modified="2021-02-10" version="1">MEEAHTKCLEQHFTSSPDCLRPLLVSLNGHNSWLLSMPRPWADQKQSGRAYFHIVLEPWLVGPADLVGSWFIHIDLPSAPAFPTADAVEAAARQIEDLASEHVLNRRMSNEVFNPARHIDAILLSFHYCDHLHEATLREFHGNVPVIATPQAARIIRPWNHFCTVAVIHDLKPAATSWRVSDLHPGPCLPPWLAVLRLPGHREMNFSTAIIWTHVEDDGTEVHETILTSPHGTLLDQGPFQAFLNSEPKTRKLAMLHGNKESHIGGKQTSFGAKGGLGLYRKLGGPKYWVLSHDLPLAYAGIFMRLSRAADTPRTLEWALDHEFLEQGLHRKRPDVFKMTNGGCLVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR60</accession>
    <name>A0A7D5YR60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g029110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541256.1">
        <property type="nucleotide sequence ID" value="XM_014685770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR60"/>
    <dbReference type="GeneID" id="26245891"/>
    <dbReference type="KEGG" id="mbrn:26245891"/>
    <dbReference type="OrthoDB" id="2131339at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="POSSIBLE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="245"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="307" mass="33919" checksum="51B1DF6537B09D6B" modified="2021-02-10" version="1">MKDKNDVIHEFNDLVNMTAAELEKWLKSGDSQAVGWPKEDDGGGESVGHDSGRKIVQILKDNPQKSPDKYTDDQIEHMRKVVSYCKRHLAQESKSNDNKSAEEVKKTKSYASLKNWGHDPLKEREGDGDEDEDEDQDEDEDEDEDEDEDEDAGQDDEQDVGTKRGTKDDQDGENKRQKTDKAASKNQKNGHSGAAKSANKQDTKDDDATEQGSQPSSDEDDGQESKKSDKSDKNGSSGKKEPKKGDTVSWEWGQGQPEGTVKQVKHEKASVTTKKGNTVSRDGTEEDPAVVIDAGSSKAVKLNHELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRD0</accession>
    <name>A0A7D5YRD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g033720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687813.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244100"/>
    <dbReference type="KEGG" id="mbrn:26244100"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="742"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
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            <end position="315"/>
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    </feature>
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        <location>
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            <end position="338"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
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        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
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        </location>
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        <location>
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            <end position="684"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI66701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="947" mass="100121" checksum="36EE74A61F0E8528" modified="2021-02-10" version="1">MNHPTAYTPLESLFLFQSLLTHGADTGAFVRISELLRNNALVKSDKSFDAARLAPDALQQLFLLLLREEVKSGTGSTTTTTNATTATAGPSTNTADTSASPASRKRKLGSPPLPSLKDAYEHIEKVPALLDRLYARYRDTIVKEIREDEEKFATVQKHIQFLEKNEKERLAKAAASQNGASMLAPRDGRPIPGQPPTPTPGQAGGIKRPVSTTPVYPPRPPSTSTTQPTVAAPSHLQSGSTTPVRPPQPSPKPPTTAGSGLQAPAGMPQPGSRVLQPPGQPPMPTLSPRPDATVALKPKEATPAAAAGQATTAGTLKWEKPYQPPIPQTPGTAGQTQPLAPANAAAGASKESQQQQRLPQQQGQYAGQVLAPTVAAQGRPIPGKQVLVAPQNAGQLSTPLQPAPPRPGGVSASQGQPPQQHPRPISTTPVIPPSRPLPPQQAQQAQQAPRPIAAASQTPQKGVTGPVAAPQKRTPAQAAQKQQTQRPSPSASPAPLAQKDRPYASYNREPPRPAIPEHIIRQAAVAQAAAAAATPNAKKISPVTAAPSTPSVTTPIAALTRGFGTKWASHSTPSTPRPITAEPESPAYEPVSPPPRDTSILSDTPRSSSKRDLTKGGLKADAVKARGRPPRISHGGRRMSTTPSVSGTRRSQSVVSQADELAMDHPISSTKIKHEVLTPRHIEETGDTTADESVHGRTNMATPGSVSSRLAKRKRQDSPSVPTAPPTQVLWTRGFTKVSSSALDQISSHRDANMFATGVRERDAPNYRQIVLQPQDITSIRSAIKQGNKAALQAASSLPGGDPGTASVWLSISEDLIPPKGIINSAQLERELVHMFCNAIMYNPDPDRGPGPAFLKRSQDEEEEVVGYRVDENGVVKNTRSMFVEVEKLLGDLRSAEKDRGVPPPSATRPASVATPADDTAEDEDELAGDGNTATSVVKRRRVAARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRN1</accession>
    <name>A0A7D5YRN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g035450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546940.1">
        <property type="nucleotide sequence ID" value="XM_014691454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRN1"/>
    <dbReference type="GeneID" id="26239503"/>
    <dbReference type="KEGG" id="mbrn:26239503"/>
    <dbReference type="OrthoDB" id="10044044at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="34"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="21401" checksum="8119F07D6634AF92" modified="2021-02-10" version="1">MAGDEAATSDAAAAQTRALPPLTDHDFKIYNRMADRMEQFHNYFRQTWTLLWTAATTSRRPQNLTQKQFLQEAISFARHLSAHHGIEEAHVFPLLATRMPEFDARRGSLVKQHEQIHKGLQEFERYVKECHAGRDEFEMGVLKEKMEGWGGVLWEHLDDEVRMLGAERMRAVWSKEEMMRMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS76</accession>
    <name>A0A7D5YS76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">msk1</name>
        <name evidence="8" type="ORF">G6M90_00g059130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014689000.1"/>
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    <dbReference type="GeneID" id="26242898"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="245"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="616" mass="68912" checksum="7AFCD21E580773DB" modified="2021-02-10" version="1">MRPSACLRLARRSSAISQRCSATSTSPSIRISCSLSLETTHFRAGARRLFSESVKKASRFTGAQDSSESLSPFKQHRRDGLREDQQSEDPLYPDPYPRLESSTTRKSVPEFLEDFDEQAPSEEVTLSGRVRSKRVVGKSLIFLDIVNEFQKVQIMINKNKCVSEKHGRIQKFSLFKNLIQVGDHISVTGNATRTKAGEPTLQAIQLPELLSPSMEQIPEKLTDPKARMADRHVDMLVNREVVDVLRLRAEITKFMRDHFHSKRFLEFQTPILAENAGGAVARPFVTQATEFRKKDLALRIAPELWLKRLVVGGVDKVFEIGPAFRNEGVDATHNPEFTMCEFYSAYTNLADLIKETEELLYGLAKHTQELISTQLTTLPPTDLSRFVRPFRQIEFIPGLEEAMGIRFPKLSSDDALPELLAVLKLAGITVPGEVPNSLPKLLDRLAAVYLEPMSFHEPIFITNHPACMSPLAKGFLCPKTYQLVSARAELFVGGRELANMYEEENDPEEQKRKLAFHRTLVNKPNGEVGFEEAAGEQEPTPAEEAEVDEWEGSPLDQSYVKALDFGLPPTGGWGCGVERLVMLFSGANRISDCLSFGTLRNVVGLSTDEKATDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT57</accession>
    <name>A0A7D5YT57_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543209.2">
        <property type="nucleotide sequence ID" value="XM_014687723.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT57"/>
    <dbReference type="GeneID" id="26244010"/>
    <dbReference type="KEGG" id="mbrn:26244010"/>
    <dbReference type="OrthoDB" id="5146350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="537" mass="61285" checksum="891ECC7FB74616F8" modified="2021-02-10" version="1">MSSSIPNTKPHYAHPRLALAPAMTDNPFFLYRPDTPGTLGKAKLKERNFVLPNEKVQDHGQLPQFMPRTWWPSERDAEESQARPALNLAIDWLDPAAVHLLHDDATKTYPRLEPMPPYKDDVYDGCQWKTQLAIAHNLFHKTLQNGNHVSAMEMTVLVRIVTYGMFDSTTFFAPFVVDGAGDVLKSHLDPNQAGKPRELRRHTRAGEPPKDSFNQRDLDWSRTRMRARRWVVVPVLHECRQWNMTIFDREQGQLYIFDCGDDEARLQRFKSAIRVWVLLLDILGQRHSFLFFVPRVTRQGEMESGPVCVAWLMEALRNQVGGQMTSRDDKVVMAEISDGNLSLCRQSGAQDGDHYTSSLHLRDWVPKVPEGERSLKPKAQLIAVRRIIRVMVANELGLRNHPVMKQRYNKVGGRGDDRPSSAITLLKEAARYALNTGDVMEEEKYFTGQGGQQFALPTGRLVLPYDAEAPRRHKMPRTSATPAIDMAKDGLRGPPRTSVEFFRSSDVPEMRITRRKSRLYKRRALAAPGNDNGFNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTR9</accession>
    <name>A0A7D5YTR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g004190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542071.1">
        <property type="nucleotide sequence ID" value="XM_014686585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTR9"/>
    <dbReference type="GeneID" id="26245102"/>
    <dbReference type="KEGG" id="mbrn:26245102"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="304"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="799" mass="86939" checksum="6533C111C4E64A97" modified="2021-02-10" version="1">MKKISRILSRRRPDDAADSDSERSRRRAGSPTAMPPPAATGFHQLPFRRATGSEVALARTHRKLSAGVGGGCVVADGSRDDDAGQQSGRRGLLTKTCPRCAAADFPRLLDWKHGQPRPWVPLSHVLLPPPGLPPSPPSDGDSQRGLTPPGAPQCPFCVFFRAMIGPVPAVGDGTAKFHPYLRIRRAFERLDGVGERHELAGSVMIEVMTRKRSLPWGYLVKADEDEGWSRYVEAQGEASIRARVVPAMVDPALPRCWLDFCREKHAGTACMAPVEMVRGLRLVDCTEMRVVAAEEIQARGETDYLALSYVWAQTELDSSPDAPSDTSASTLGPDGRLPESVSPLFADAIAFTRSLGCRYIWIDRFCLPLPAGERQKQVDAVGEIFSQSLLTLIVAAEDTSLGGIPGLSTPREEQLCLKTKTGLYATSLVRPDLEVASSKWASRAWTFQEGLLARRRLIFTPSQMYFQCRTLHCHESLSLPLRLAPSISLGRVFPAGDGCPRQPGQFKDLIKTYMCRDLADNEGRLDALRALLREYARMGGLAVKHFLGLPLFHPDDFVTNRVVSETDRLAAGLGWICDWTGSVEPSCRRTASFPSWTWLAWNLREGLTAADSKFAFNLVGGVSPILHGVSAAPRMEISVGFKDAAVLSWEIDGDAISKKSEAIAFLRLETFSFDLEFTVEEAQAKLGDVALASENRALVEAMITASLSGQEDGASGFACLGVLVSGRNWKGGTDCAATALICGRQTSGEDAGAWIRLGAVAIECEAFVDGPEEAVLKGVEVDEGQKKDLSVRLRELDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTV1</accession>
    <name>A0A7D5YTV1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g060770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544646.1">
        <property type="nucleotide sequence ID" value="XM_014689160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTV1"/>
    <dbReference type="GeneID" id="26243058"/>
    <dbReference type="KEGG" id="mbrn:26243058"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="104"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="335" mass="37008" checksum="6356F63F5EB97E7F" modified="2021-02-10" version="1">MRCAALPRRLRAASPSPACKSPLCRRGWPRNPSTKPALGLPAAPRWAHSDRRLTILEHVHLKGDPLTGLAPYEQAEDAQEQHRARFLQWKASSEEQRLSAPSCHVPRPRLLSFEATPTFTLGRRQEDLTAEQATRLQQPLDIGLGHRRNPIAHRFTPQVRKTSRGGLTTYHGPGQIVLWPIIDMHSSLYPKYGVASYANHLETTTQRLLSELFGIQTYTARDEPGVWVTTSSGQERKIAALGVHHRRYVTALGIAVNIDVPVTGGEAVNPWARFVPCGLDGRLVTSVAAEVGVDSALGWDLEDLAGRWATLFDEGLVDEAKRSVGGGEARSRLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUK0</accession>
    <name>A0A7D5YUK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g056760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986807.1">
        <property type="nucleotide sequence ID" value="XM_066130624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUK0"/>
    <dbReference type="GeneID" id="90967803"/>
    <dbReference type="KEGG" id="mbrn:90967803"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="42" mass="4896" checksum="CEA9EAAAFFC588DD" modified="2021-02-10" version="1">MPLTTEEKGEADKPPKPKKNIREYFEKIIEAEMTKDESDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV23</accession>
    <name>A0A7D5YV23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AIM24</name>
        <name evidence="8" type="ORF">G6M90_00g043350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547670.1">
        <property type="nucleotide sequence ID" value="XM_014692184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV23"/>
    <dbReference type="GeneID" id="26240233"/>
    <dbReference type="KEGG" id="mbrn:26240233"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="384" mass="41731" checksum="991300CD00D3F093" modified="2021-02-10" version="1">MMRGSSPLVRSTRGLRLQRPASFVCWQCRSIHISTAPSTESPRVPGDAFGAPIDGARDMADARFEVLGSPYSLLSVTLSASQKLYTRRGTLVAVAGKPDNAQSTLSLLNPVTRAAFGVPFVYQRISATTPITALISTKSPTTTFTVLHLDGTTDWMVSQRNALLAWTGHTLTLSSRIQRRLALAHWGSTQLTGRGLAALSAPGQIYQLTLGEGEEFVAHPGSVVAYSVSRNAPQPFRFKSTSLRLQVPSLTSWIPEMEFVKTVRNSDVYKFLAGALHNFRTMARRTIWGDRLFLQFKGPATILMSSRGVRVADVLSREQVNEIADAPAGVLPSAVELANKPKQGGQVLDKSQADEAASNLQVGSPPKDSKVVLEEGRELKEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV58</accession>
    <name>A0A7D5YV58_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Satratoxin biosynthesis SC1 cluster protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SAT4_3</name>
        <name evidence="19" type="ORF">G6M90_00g054870</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540919.2">
        <property type="nucleotide sequence ID" value="XM_014685433.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV58"/>
    <dbReference type="GeneID" id="26246225"/>
    <dbReference type="KEGG" id="mbrn:26246225"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028929846" evidence="17">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="460" mass="51486" checksum="7E3FCB8713497D14" modified="2021-02-10" version="1">MKLWASLMLALAALPMIMAQDSSLTQTLAKFPGCAIPCLGQSIPKSHCSMTNQTCLCTDQVFKDGLTNCVMSSCTIKEAIMVKNLTSTSCGDPFRDKSGQYAVVSKVFAIISSMFVIQRFAYKFWAKLEYGLDDWFVLLTTVVGIPTTVMNVHYVAPNGIGRDAWTLTYDNIINFGRYFYILEIIYIVEVSLSKLAILFFYIRIFPGRRVRRVLWGSVAFVALFGIAFTFSAIFQCTPIDHNWLKWDGIHEGRCVNINAGAWSNAAISILLDGWMLAVPLWQLKALNLDWKKKIGVGLMFGVGTFVTIVSILRLKSLVKFGSDSTNPTWDFFNVGIWSVVEINVAVICACLPTFRLVLVRLFPRILDTSQRFYAKHGTKNGYKSPTRRGSRPMGTTSVSHVERSQNGREPLSKHITFHKTFSIEYGETDPEHDAAQLVYMKDLEMKSHQPDSLSGGSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVM7</accession>
    <name>A0A7D5YVM7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Succinate/fumarate mitochondrial transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SFC1</name>
        <name evidence="12" type="ORF">G6M90_00g017430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548787.1">
        <property type="nucleotide sequence ID" value="XM_014693301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVM7"/>
    <dbReference type="GeneID" id="26238231"/>
    <dbReference type="KEGG" id="mbrn:26238231"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="323" mass="35153" checksum="A27FDBE1780FD694" modified="2021-02-10" version="1">MPPSDNNRKPPTAAVNLIAGGGAGMMEALVCHPLDTIKVRMQLSRRARQPGAPKRGFIKTGVEIVRRETPLGLYKGLGAVLTGIVPKMAIRFTSFEAYKQMLADPATGRVSGQATFAAGLAAGVTEAVAVVTPMEVIKIRLQAQHHSMADPLDVPKYRNAAHALYTVVREEGFGALYRGVSLTALRQGTNQAVNFTAYSYFKVWLKEWQPQYADPGTNLPSWQTTLIGLVSGAMGPLSNAPIDTIKTRLQKTPAQPGVGAWARIAAISADMFKQEGFHAFYKGITPRIMRVAPGQAVTFTVYEFLRQRIERSNMSFVGGNYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXZ5</accession>
    <name>A0A7D5YXZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g032250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543160.1">
        <property type="nucleotide sequence ID" value="XM_014687674.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243961"/>
    <dbReference type="KEGG" id="mbrn:26243961"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000817">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="7">
        <location>
            <begin position="519"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1355"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1017"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1076"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1366"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1397"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1432"/>
            <end position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1616" mass="177801" checksum="3DCF712B22CC64EA" modified="2021-02-10" version="1">MDLPPAPTPPVNSGGMPSNKDRTASLLNLLKFSSGSGSSNAQHQHQHAQQSHHQQQQQHQHQSREPSYSQPEYSSPPTRILQPAPAGADPTGLLAALMRGAHDAHDTDDEARQPAPAPAPAPAGHEPTQQTQPAVTNPFANGSPSNDTRSYLLALLNRPKPSQNDQPMLTETSRSKGAASQSPEITTDSNRFFNQYQHQQPQPQPQPHAYQQQAHHQHAQPQFHQHQPPNSMREAYHQVSNDSSYAYQQLQLASQDPPADPADMSALFQQLMGSLTQSSPQSHTSQPASHLSQPPFQILKKEQSSPAGSQPRAGSERSPLASPPDQSRHATNRKSSLHVHKSTAQSPKQALPVEFESSISAEKSRETVAEAVNDLADQADKDAQEALDRAEHDLVPAGFVEDEGSKEASGQEWPSKIAHTEIVKSVEEQIVQNIKNGLEKNEVYRATEMSYMNDASDSGNATGENVRGVADSWESADLEETIEVEEEKELPQVRVYKFPQEPWNSISLKEETDEIRPEFRDESIMDIARLKKEFDQIDRNLFTASQTYMTYGMSKQGGLRVIRQDDGKDAKVFTDTKDRIFNVAMSVTPPESGNVHREAIIGTGVGGAVYWVQIKDGEKDHIEDPHLEQYGFALPPISSHDGDAPGGLLKTRARASTAHPEFFAVGRGKSINFIWPAYILQHKLFKAGHDRVVDTEALLAQCSLKINTGKAGKDFTFSQDDSVVVSLDKSGRVKFWDVRALTKVKEDSDYRYPLPAESSLEVKEPLMTLATTPEGEKAWPTSVLLLDRKKAYEQRGPLRYMVVGMKQNHTLQVWDLALGKAVQEFNLPHSKESDAVCSVMYHPASGMIVIGHPTRNSVYFAHFSAPKYSLENVSQVDYIEKLLQPLKPNEACLIRKPSSTAIISGFREYSFANRGVLRSLDILYTPIAKQGMGHMAGQDPKDKDRLRFELYAMHSKGVACVMVKKSDLGGSDNTLVLDAVKEGLVTVSDFNKPQAVDPSHGGNQQAKNTAHRAVPKQSPSQQSTSAAQSDAAQRGSDAATPSKPSHEAKEAETPAQSSKEGQAEKPERKSRKKKGNAAAKEAEANGATNPPRGTQAGRAESAAKSNSTAAVASGVTFEVLDSTINTMQTRLTAVVSDTLKSSLKNLHVKIDESARLRDENFNQHQLKLLDMVSEVLNENTQKVLESLIHHQFTELLVPAIGEKATIAVSDVLQHSLQPNVASAVQKEIQSALPQALNRSLRSVDFVTAIAERVGTAVNSTVQQEIVATLSQRLTPTFRNMATQSAQQAAAEVHQQYNDKFEQMQSQHAADSSKIDQLLSYVTTLTDMVSTMAASQSSLQAEFLKLKQQPVHELPGASGLQSQARDGGPGFRGFGPQGGYPNNGFMAGPNPHSSFTGYQTNQPPTYQQQQQQQQQYMAGPDYLRSGQHVGSPRDSTSQTDVTSASKVASVGGPFANHGSNVDSEADRDVHDVEVLIQDEKLQEALLKWIKGGHQREVFQRSLSLQSPSRFEHLPPVLLLAAIGAISKDLDVNNLLKQRIDWIEMAVRSIDRRAAERDWRELGREVVKQAYDTICWFIGKLNTLMEKYETGYALERRRLEWIVGSSEHILQTLDRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY07</accession>
    <name>A0A7D5YY07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alginate lyase 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g050950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545195.1">
        <property type="nucleotide sequence ID" value="XM_014689709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY07"/>
    <dbReference type="GeneID" id="26242536"/>
    <dbReference type="KEGG" id="mbrn:26242536"/>
    <dbReference type="OrthoDB" id="4221926at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33681:SF4">
        <property type="entry name" value="OS12G0171100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028874725" description="Alginate lyase 2 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21973" checksum="C77898059D3A7D0F" modified="2021-02-10" version="1">MLVNTILVALSAASLALAGTPVESGNWVEDHPDYSQQQCAGGRVNGNTFSIPKSPNGDTSGSGCSNGHLRAERRYKDDYSSGVHQFGGEFKINSMSGSRISIKQTFNGNSGPYFIMGVEQGGRLYNVEGGKTIADGVAKVGATVRINTVHNANNHRFSVYVNGKEMLRDENAPGGSFYDKIGAYATNSGTGDLSITWNDVQFWHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYM9</accession>
    <name>A0A7D5YYM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RNF1</name>
        <name evidence="10" type="ORF">G6M90_00g009450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549569.1">
        <property type="nucleotide sequence ID" value="XM_014694083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYM9"/>
    <dbReference type="GeneID" id="26239013"/>
    <dbReference type="KEGG" id="mbrn:26239013"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028970198" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="146" mass="15700" checksum="06C3ADEA3D2E2B84" modified="2021-02-10" version="1">MRLSFTFFLSLIALAVCDTFSCGDTVYSSKKLTTATGEACSLLKKGRSVGRNKYPHEYRNLEKIKLTGSGPYYEFPVFANGEVYDGGSPGPDRVIITKDCKQAGVITHKGASGNSFVTCSPTSVGTLNSQSVFALCFAMMLHAVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYN2</accession>
    <name>A0A7D5YYN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g060200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544590.1">
        <property type="nucleotide sequence ID" value="XM_014689104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYN2"/>
    <dbReference type="GeneID" id="26243002"/>
    <dbReference type="KEGG" id="mbrn:26243002"/>
    <dbReference type="OrthoDB" id="4931840at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="80" mass="8553" checksum="70C11B6C73BE0693" modified="2021-02-10" version="1">MVLHSNPLRGDESTPSSISLGWNVIINRTATPDPVDIDDIISYGAQIPGTRCPTCALKGKEVWVIPGRNCGYCGTPCDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYR1</accession>
    <name>A0A7D5YYR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylase/desaturase asaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asaB_2</name>
        <name evidence="2" type="ORF">G6M90_00g096460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546688.1">
        <property type="nucleotide sequence ID" value="XM_014691202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYR1"/>
    <dbReference type="GeneID" id="26241111"/>
    <dbReference type="KEGG" id="mbrn:26241111"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="300" mass="33690" checksum="8ED52F51FE30D588" modified="2021-02-10" version="1">MAAAAVQTPLVLSTNTTPQVLQRARERSVPKHDVTTTLKYHKDNEDGSPPHPSYAGRAETFERPFEPHQVTVRDIAGEEANYTLDRNGFQVHSHIATEKAFADDDQIKSSYYPETEQLLKDVTGASKVFIFDHTIRRQPPGATADRALRGPVQRVHIDQSYSAALSRVPHHLPGEAERLLRGRVQIINVWRPISTIERDPLAVAEATSVSDADLVVTELIYPNRRGETYAVRHSPGHRWFYRSGLEPGQVLLIKCFDSKTDGRARRVPHTAFEDAAAREDAPARESIEVRALVFHEHDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ04</accession>
    <name>A0A7D5YZ04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g008340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985826.1">
        <property type="nucleotide sequence ID" value="XM_066129647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ04"/>
    <dbReference type="GeneID" id="26239117"/>
    <dbReference type="KEGG" id="mbrn:26239117"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="830"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="875"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="112"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI64747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="947" mass="104007" checksum="677D9883DAD05114" modified="2021-02-10" version="1">MQRDASSETAPVTSSTIPTTSRPENPSSVPGTGPATQIFDNICTSTGQREGGGSSHLDPESPVVLLPGDGTDTYELADYGEIQESKKAHAVEKRRQEKRDRKRQWIETQDEMKFSHSIQFNAVPDWSSHYIAYSNLKKLIYQLEKNAHQSRAGGDSESRPLISSEEPTEVFSRALGIELEKICSFYVAKEGELLDEVNQLVRDVMERPSLESPDLRRMSLGEYNRPHLRPLSSTGLASDDDMDDSGSDDDETTGLHKPKSSSGRRRTIANIGQHQVDLAASSEFTRSVRRHSTVEDFGDQSVMFASGLFSSSIMLKKRIVSLYVQLCELKSYAQLNKTGFSKVLKKFDKILDKELKGPFMRANVDTAYPFKNETKKIIEENIEKMEDAYTEVVTAGDRELAKKDLRSHLREHVVWERNTVWRDLIGIERRGEAARFGQSLLGQDQTAAHKRLQGDDEEIAAAKQFRTPLGRLSLPTWLTDSSMLTLLGCLGAFAALLAIPIMDKPEEQNCLAMLVFVSLLWATETIPLFVTSLLIPFLSVVLQVVCDENGSKRKRLGAKQATNAIFAAMWSPVIMLLLGGFTLAAALSKCKIDKRLATLILSKAGTQPRTVLVANMFVAAFASMLISNVAAPVLCYSIIEPMLRTLPSDSDMSKAVIIGIALASNIGGMLSPIASPQNVVAMGIMKPEPTWLQWFFIVIPVGAVSIFFIWMLLLVTFQPGRGTAIAPIRPVKERFTGVQWFVSVVTIVTIALWCASHQMDHIFGDMGVIAIIPIVLFFGIGILTKEDFNNFPWTIIILAAGGLSLGKAVRSSGLLHTVAELVSKNVEGMSLYGVLVVFASLILVIATFISHTVAALIFLPLVFDVGMSMDQPHPNLLVMGGVLMCSAAMGLPTSGFPNMTAIMKEDATGQRYLRVRHFISRGIPSSIITLAVVITLGYGIMQVAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0C1</accession>
    <name>A0A7D5Z0C1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g108440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544002.1">
        <property type="nucleotide sequence ID" value="XM_014688516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0C1"/>
    <dbReference type="GeneID" id="26243389"/>
    <dbReference type="KEGG" id="mbrn:26243389"/>
    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="25375" checksum="7249BABC6D2F162C" modified="2021-02-10" version="1">MKLSTILAGTSIPLALANVRVKWSFPSAPATGLEDITFPMNMANAKHERGYYFAQQFNFEGISAVGYIGFQPRPDRNGKPIFLAVFSSFQKGATSTHAKCKSGADGGAGVSCAIEGSGDYADTYNFSVEHVSDTTWRGVMTNTVTGKKDEIGVIKLPSQAKNIKPSQVGFVEYFPWNANGPDCPKQPKTEITFYDPTSNTGGAGSITAIEDYGDCSGKANIKYTKITGGYTVNYGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0S4</accession>
    <name>A0A7D5Z0S4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BRE1</name>
        <name evidence="19" type="ORF">G6M90_00g013980</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549124.1">
        <property type="nucleotide sequence ID" value="XM_014693638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0S4"/>
    <dbReference type="GeneID" id="26238568"/>
    <dbReference type="KEGG" id="mbrn:26238568"/>
    <dbReference type="OrthoDB" id="654191at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058643">
        <property type="entry name" value="BRE1-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26095">
        <property type="entry name" value="CC_Bre1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 15 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="661"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="271"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="542"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI66147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="713" mass="80824" checksum="EC1E25C7F2BBD5E8" modified="2021-02-10" version="1">MEDRKRPAIGGSDDLAAPPSKRVAVNGSKTKDDAIEMKEEGWIEAYTKGAIYRQMQEYSRKAATAESRLEELHKRCVHHDDHLRIIDGWWRQLLEELEVAAEPTLSGNAPTTDPPYLSAIGFKDLSEFQSHLSDKGKTIKTKAESLLSRIASQRGSLSPDAASLEAKVNNLLAAQKEYMLKLDRLNTEKDQLSEQLNTATLRYFKAEKKLDRAKSSQVQKLEQQAFANATRPSGATAAAAAASGEVGSEQHEVNGSSDELLLKYEETTASAAKQKEQLDSILSELKTAQDENSTLKARQNTWSDEDFIRTDVFKQFKAQNEDLIKRINNLEATNKQLREEAEKLQAERTSYKTQLETDASQVTQELEADVITRDQDLARVRSARDEILAENTQRKASMEQEKASLGHVKELISAKDDRIAALESRLSRLEPAEDQEMVNADDLTELSEDELRQRYKKLQQDFQSINQELPSIEKAYKKMKDQAQKKVLDFVALEEKVSLLIAEKSKADQKYFAARKDADTRNNEIRSLRHQNSKSTEIITQLKDLEAQNRLLLGNLEKQVADLKQSNALLTAENKKMESTSLEAVRRSDSLNRQISDLTSLVKSRDNASAAVRERNTVQEAEVEKLKVRIEHTQKDRDNWKNKALSNSSEEEEMLRTFALCTICRNNFKNTALKTCGHLFCNKCVDDRISNRMRKCPTCSRAFDKMDVMPVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1A8</accession>
    <name>A0A7D5Z1A8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g062830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542599.2">
        <property type="nucleotide sequence ID" value="XM_014687113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1A8"/>
    <dbReference type="GeneID" id="26244548"/>
    <dbReference type="KEGG" id="mbrn:26244548"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23049" checksum="864C31C856202983" modified="2021-02-10" version="1">MSSRKKVLLKVIILGDSGVGKTSLMNQYVKKKFSASYKATIGADFLTREVMVDDRQVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNAKSFEALDSWRDEFLIQASPRDPPNFPFVVLGNKIDVEESKRVISNKRAMTFCQSKGDIPYFETSAKEAINIDQAFEVIARNALAQEESEEFSGEFDDPINIHIDNDRDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Q5</accession>
    <name>A0A7D5Z1Q5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cys-9</name>
        <name evidence="11" type="ORF">G6M90_00g059170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544490.1">
        <property type="nucleotide sequence ID" value="XM_014689004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Q5"/>
    <dbReference type="GeneID" id="26242902"/>
    <dbReference type="KEGG" id="mbrn:26242902"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34147" checksum="A766B57FA7C73DBD" modified="2021-02-10" version="1">MHSKVVIIGSGPAAHTAAVYLGRAELKPVLYEGFMANGIAAGGQLTTTTEIENFPGFPKGIMGQELMDNMRAQSERFGTEIVTDTVTKLDLSSRPFKYSTEFSPDETHTADAVIIATGASARRMNLPGEQTYWQNGISACAVCDGALPLFRNKQLYVIGGGDSAAEEATFLTKYGSHVTVLVRRDVLRASKAMATRLLKNEKVTVRFNTVATEVRGGADKLMSHLVVRDTVTGKEEVVEANGLFYAIGHDPATALVKGQVDMDTDGYIITKPGTTMTSIEGVYAAGDVQDKRYRQAITSAGTGCMAALEAEKFISEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1U5</accession>
    <name>A0A7D5Z1U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SSGA</name>
        <name evidence="4" type="ORF">G6M90_00g064280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540114.1">
        <property type="nucleotide sequence ID" value="XM_014684628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1U5"/>
    <dbReference type="GeneID" id="26247150"/>
    <dbReference type="KEGG" id="mbrn:26247150"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029014258" description="Hydrophobin" evidence="3">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="94" mass="9626" checksum="62BB08826A4314A5" modified="2021-02-10" version="1">MFKALIVALAAVAAAIPTQQPSSNKIECNNTVFCCDKQTVGQAGIPIDALNPTCTNLNVLAVDALNPPCPGQTVCCNNVQQNGVVNVACTPISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z272</accession>
    <name>A0A7D5Z272_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g067470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540504.2">
        <property type="nucleotide sequence ID" value="XM_014685018.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z272"/>
    <dbReference type="GeneID" id="26246611"/>
    <dbReference type="KEGG" id="mbrn:26246611"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="786" mass="87960" checksum="FDD0B1A5F6C44E02" modified="2021-02-10" version="1">METKRGDYAVCDLCRAKKIRCGREKPSCANCSRLGQVCEWSGQGKKCNQTALLRQTILGLSCRIQTLESSMLDNEKTPKGLCSVALPASFGSDARQSSRTRPSGMQSRDVVVNHGFTKPQGTFLTIPSQGLGEKLFGPTSLESLMLTFKDTLADGLDPETTPALKECSDLALCDVSLPMNQREDLPTDESLPTPPPSAILNAMIEPYFATVNAHFPIWTKRQIEEMAATLEQSTSTERDAATMICCNNLILMTLTANSLRSRWGKPLQTKHRRRHLSIDSDITAGFLMNAKRAIKHVELLLSPCLVNVQALLSLCIVAQEHLSLYLVEAIFSLAAQCAKSTGIHQWEYFRGHFNEQAAQERRSVSYCLYILDKTVCWTTGTSPSIPASDLLLDYTLAPDDGGTMAYLFARTELAVIEEMIYLRVYSNQVEVRTDDQVRQVAAKISQRLQDWLVSWRIHLNEVESHQKQPVWKAKLAVDFLCVQLLLLWPYESHPDALFHQQTHIARRCMRLVLHLWQSTQEGGLHVAIARSVVYNTQVPRRLLVLVTNWFNWKQNADFCKFSCSLVASHPPLYLHAIYMQGARGRGQEFDQDLLRDYTEMLEVIADSQGENCYNRRLCQISRFLMRVKTTQNTPNKRQKLNPRATSATSIPSPQSGSSLSNGSPIQVHSPSRTSRFMALERHNQEGGISAGGLDDSLNLLSPSEQSNMGQSQPLADELETATSYTSDFLGQYDAVDFDSRAADEEFGVCDNLWLQQGGLDQPSTSPPARYAVGADWGMTEFPPFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2N7</accession>
    <name>A0A7D5Z2N7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome b5 reductase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cyb5r4</name>
        <name evidence="6" type="ORF">G6M90_00g025360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548047.1">
        <property type="nucleotide sequence ID" value="XM_014692561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2N7"/>
    <dbReference type="GeneID" id="26237491"/>
    <dbReference type="KEGG" id="mbrn:26237491"/>
    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="242"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="336" mass="36033" checksum="D69FBF791F24FB60" modified="2021-02-10" version="1">MGLLGISLIVASVVYVIIRPPGWLAHILLQWRPSGGVIADTPTRQKRVQDDTAPRIQEDALSIEEPLHSLNGLAKKATPAESKQLKDAAVMPPSPPQSVIELPTLMVDEPEGSTTPKAMANKPSDPVPSFSLSPEPLTSSKSSSSMMPPPPLPARLSAGRMPTLPQFPAPNSAQRARGPVPNRGPPGLSVPSAGLTPPPTHSSKPQKPSRKVLLDPGHSPLDWARISGPNADLRGVEPSTPYLRVTPSMLRNQTGRKGKDAWMALNGKVYNITPYAKFHPGGIPELMRGAARDGTKLFGEIHPWVNYETMLSACLVGLLVEEPDDGSQESEMDKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2T7</accession>
    <name>A0A7D5Z2T7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g088420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987482.1">
        <property type="nucleotide sequence ID" value="XM_066131328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2T7"/>
    <dbReference type="GeneID" id="90968092"/>
    <dbReference type="KEGG" id="mbrn:90968092"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5629" checksum="54221EF19C65BA7B" modified="2021-02-10" version="1">MGPLPPSIPFVGDENAGDDLCDQGAGMVQKWTDFLVEEAASLWVREVMFSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3D5</accession>
    <name>A0A7D5Z3D5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CYP10</name>
        <name evidence="7" type="ORF">G6M90_00g033810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986417.1">
        <property type="nucleotide sequence ID" value="XM_066130135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3D5"/>
    <dbReference type="GeneID" id="26244109"/>
    <dbReference type="KEGG" id="mbrn:26244109"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="19908" checksum="45B362B3BAF40FEB" modified="2021-02-10" version="1">MSVTLHTSHGDIKIEVFCESVPKTAEARHLLPPPFLFLYGKNFLALCASGYYDGSPFHRLIPKFILQTGAPAHPGPDDPKGGRSIWDAAFEDEIRPSLRHAQRGTVSMANKGPGTNGSQFFVTLDKAPHLDGLNTVFGRVIGDEAMATLARLEAEEVDRKARPLARGDVRIDRVTVHANPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3J4</accession>
    <name>A0A7D5Z3J4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g068680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540024.1">
        <property type="nucleotide sequence ID" value="XM_014684538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3J4"/>
    <dbReference type="GeneID" id="26247244"/>
    <dbReference type="KEGG" id="mbrn:26247244"/>
    <dbReference type="OrthoDB" id="2117996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028814206" evidence="2">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="196" mass="20797" checksum="EF281F5437B98926" modified="2021-02-10" version="1">MKPPTLIAILAVAVHAHALAASQPAPQDQLSQESEALSKRARQPSAQAIDAAARSWQRDTGVVSQFLSTAESMSPQQLQQQARGALAAENDELTHKAVLDQMFLTGARRNRDATVRQANNVLETQGTFQFVVDGLQTLSRRGARMSPGQVSAMIRAINRDRCPQVLPAIDAYMAAAAGAGAGQTGNALTAIRPSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3K5</accession>
    <name>A0A7D5Z3K5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g000840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542984.1">
        <property type="nucleotide sequence ID" value="XM_014687498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3K5"/>
    <dbReference type="GeneID" id="26244357"/>
    <dbReference type="KEGG" id="mbrn:26244357"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="51"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="553" mass="59831" checksum="FA1BFD5E6FA0D894" modified="2021-02-10" version="1">MALPVEEAAKQADAIQPTSSIPGYSETVAEAKPDVEQQHIGTLDRRLKSRHVQFLALSGAIGTGLFVGSGQVLSLAGPLSAFLCYAVTGFNLYCVINSLGEMAAWLPIPGAVPVFAARYVDPALGFTLGWNYWYQFAIGVPIEATVCGVVVDYWPNALPKAALVTAFSATMVLVNCLPVRVYGEAEFAFGAVKLVTIVGLIVLMFAITVGGSPAGGAIGFRYWRDPGPMRTYLADGATGRFLAFAKVFIQATFSYGGSEMVVVASGETEDPRRNIPRAIRRVFWRIAVFYVLSVLLVGLCVSSADPGLLDAIGRSAPGAAQSPFVIAIQNAGIGTLPSVINAVILTSAWSAGNSFFYAATRVLYAAALDGKAPSALRYERFGVPYGCVAATAVLSCLVYLNVNNRSAEVFFWISNLSAVSTLIVWASVCCTYLRFYYGLRRQGVSRDTLPYKSPLQPFLAYFSVVFCLVVALFNGFDAFFPGNLSAKTLVPPYVDIPIFAALFLGYKFVVGTRFVSLAEMDLWSGKAEIDRLEGTWKVVEPRNWLERIWFWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z587</accession>
    <name>A0A7D5Z587_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g080840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539436.1">
        <property type="nucleotide sequence ID" value="XM_014683950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z587"/>
    <dbReference type="GeneID" id="26247755"/>
    <dbReference type="KEGG" id="mbrn:26247755"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17904" checksum="3A53CB8934E4AACC" modified="2021-02-10" version="1">MSVITDPDYMPSFSEPTPSSITDEARAFVANFYRISDMQVEDEQWVEFFTGDAQVIMGEDSGRGHCEIKELRRRMWINVLARKHQVLKVFTGAFSENSGTEGEFEYDMMLLGRVQRTSQDSKTTIQIPWASHMVLKKGPGREASQWKLARYRAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z617</accession>
    <name>A0A7D5Z617_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g057960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986912.1">
        <property type="nucleotide sequence ID" value="XM_066130654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z617"/>
    <dbReference type="GeneID" id="26242787"/>
    <dbReference type="KEGG" id="mbrn:26242787"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="5">
        <location>
            <begin position="423"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="51887" checksum="BB414E0AA3468D85" modified="2021-02-10" version="1">MAADEEQESDQLKSSITLPLQERMGRKDEDVSRHSNISQRPPFSLGSLNRKKMEEERLGRIATKRHRIICDEEDAVEIPKPKRVAIPAMNHTIAKTLVPFPRGTVKRTWALGYDRSPDDIKIEEVLQRDRLLLALFSSFQWDEAWLLSKIDTSRTKILLAAFASDDAQKQEMRINSPKNIKFCFPPMYGPGSMHSKLQILKFPDYLRIVISSGNLVPYDWGETGVMENMVFLIDLPLKTPNDIGPTSTLFFTHLQHYLRAMGVDNSMIDSLSKYDFSGTENIGFVYSIPGSHQSESLSRAGHYGLGTTVSALGLATSNPIEVDIACASLGSVKYELIQALYHACQGRAGMDKSELNHVGAGPSQRSTCSELQENFRIYFPTHETVTKSRGGKNAAGTICLQEKWWRASTFPTELMRDCVSTRDGLLMHTKIILVRHKISPETGTNEKLAWAYVGSANLSESAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6D8</accession>
    <name>A0A7D5Z6D8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tumor susceptibility 101 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TSG101</name>
        <name evidence="11" type="ORF">G6M90_00g110970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543763.1">
        <property type="nucleotide sequence ID" value="XM_014688277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6D8"/>
    <dbReference type="GeneID" id="26243150"/>
    <dbReference type="KEGG" id="mbrn:26243150"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="460"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="527" mass="57851" checksum="164CBE068492DABF" modified="2021-02-10" version="1">MPVQQHVLNWLYSVLTSEYHDVNRTYHDVAQALTQYPTLSPRTDVHTFSNGSSALLLHITGTIPVNFRGNTYRFPISIWVPHAYPREPPLVYVTPTDNMMVRPGQHVDPQGQVYHPYLVGWAQFWDKSNIHDFMSVLSDIFAKEPPVVSRQATQPQPQQPPIQAPPPVPPLPPEMAPRPPQTLQSSTNGSRPPPPPPPKEDQTPQTSTHPASPSSDTTVRTSSVPSRYESAPPLPTQAPASPPVVRHAQPSSQFQQLSQQQQQQQQHTQPPTGHWLPHGPHSSSQNPPYSAQQVPSHQLPPQWQALGPPPPGYAVAPGVGMPPHIQQPLVQQPAPPPPNILDEPLTLDIPEATTVAPPPIPPNPEKDNLLRQIAQTLYVIRQRSRQQNDSTMAGLQGQRSAMQNAMAGIQSESSQLTQLSNVLTSNTTILHDALRKADAVIDGSRSHPAPDIDELLVAPTIVSNQLYNLVAEEKALGDAIFMLGRAVERGRISPAVFAKMTRSLAREWYLKKALVRKIGQGMGMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8Q7</accession>
    <name>A0A7D5Z8Q7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g061970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542676.1">
        <property type="nucleotide sequence ID" value="XM_014687190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8Q7"/>
    <dbReference type="GeneID" id="26244625"/>
    <dbReference type="KEGG" id="mbrn:26244625"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="453" mass="48865" checksum="C5A3AF16920C042B" modified="2021-02-10" version="1">MATEGGQTAPVGDAAAKKDQKTRGQPKTPQQPDQAASSDAPGEKTLSNAELKKRAKEEKAARRAQAKVAQVAAPAGPPGGQGATGDAKSGKSKANNPKQGGLPVPSHHRSASRSVLPPVAKEVVKPKISECYSHLSMARRIAITQADKDVHPVVLALGQQMSTFAISDSTTRLEATLLAFKKVIDAYTTPHSNTFSRHFTSHVLNPQIEYLTACRPMCFSMGNAIRWLKLQISKIDIDLPDSDAKKVLCQAIDTFIRERIILADFVIVKTAADMIQDDEVILTYAHHKLVERSLLQAKSDGKQFKVILVDDPFDRVGLEHAKNLAAAGIPVTYASDMGALRSNLQEATVVFAAAEAMFSNGSMYARAGTCDVATVATDLGLRVVALSETINLTDRVSIDSLTYNEIDPERSTGEECRLLFDTTRDKFLSIVVTELGSLSAMSVTAILRKLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8T9</accession>
    <name>A0A7D5Z8T9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MMS19</name>
        <name evidence="7" type="ORF">G6M90_00g085890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987450.1">
        <property type="nucleotide sequence ID" value="XM_066131277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8T9"/>
    <dbReference type="GeneID" id="26246137"/>
    <dbReference type="KEGG" id="mbrn:26246137"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="6">
        <location>
            <begin position="69"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="5">
        <location>
            <begin position="689"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1169" mass="129100" checksum="37F870DE035FF4C3" modified="2021-02-10" version="1">MADFRQLALDFVLEDNKAKSVRFAQKAAKEIEAAAPNSNPVARWVESVQPWMPDSNDDDVMRDAGDTPDWTARSRALEFLSRTLHYLNPEALKPSQVNLLVAFFGAMFDVDHKAGILPSATALSRIIAMKSFHPNSGRDIILKVCTLKEDFPRQISKTRLAVYELLRSLVSNPEVAKDLQQRDGKDTAFMKDLLHLCQTERDPDCLMVWFDILRLFLSEYPPSKEILEEIYGTFKAYFPITLPRTAQSGVTPEELKLQLRKCFSSTYRLASLSLPFLIGKLDQGDGVTVNVKVDVLRTIRACLEEYKDPTESITPYTNRIWTSLKYEVRNGEIEDTIWATLEVLKSLTTRLAGDDLRDYTLTVTRDCVVDLATPMYTTAAGRLLVSVLSANPSAFVLIVAPAVTHIKENLRHPKSPTHSQDLLKILRIILETRLLLTDVEMSEHDRNDFAAVDGVFKTLYADVYKGPLELPAKPAASDEDFKLSTEAVQGVGALIGQREVKSLASDAGHKTSDLALLLPISTCAESCETLFNISTQQWDERSRRIGADELVNESVKALQRIIQAYPGGFLSIVAKASSILRQSIANLTHDSLDTIQSLGPLLAYIGCSSLSASLELSLRQFVQVVRTIELELLAAIDQTTSPRIWCFLVAGIHSTVRYFNEACLEKDAKASAVEEGTLSSDQIVVKYPQLSSATAFSEPAVPTVQSTLTSVSEARTDALLIGLHIVGSLYRRATQSTETGGQLAKSSDFDGSEPHPELRYLSLLSELAGFIVHEFNESQQASLEVEKYALNLFRGDEVNVSGPSSWTWLTSGYLGILSLGILESVRPSRIAKFYETGVAQQILTEGTATGSSVGEVALRPVRRSILAILANKHNIETLDSVMANVATSLQDALQKTRADSANGPLATNLETCFSIFSLIGGLFRRYSGNKIQPLIQLLRTAPNDVQSGYQLGRGLEIIVVPQRFLTKENFAVVRLLWLQKIYIELIKPMLEVALGKDSSITDPVIRTNFSISVLLMVKHLDFSIYEQDADKILRIAIAIAQNLGIGTDGMAALQVIKDILVEASEQAEDHIRSLIKICASIFANRQQSADRPDWLPAEYGDAVPSLEVQAGCGKIALEIVGGLPRMFESRHLLAYEPQVQRDLSTACGHRVRELRSTARLARGAWANVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8Y8</accession>
    <name>A0A7D5Z8Y8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin kinase</fullName>
            <ecNumber evidence="4">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Flavin mononucleotide kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FMN1_1</name>
        <name evidence="16" type="ORF">G6M90_00g092620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541906.1">
        <property type="nucleotide sequence ID" value="XM_014686420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8Y8"/>
    <dbReference type="GeneID" id="26245374"/>
    <dbReference type="KEGG" id="mbrn:26245374"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="15">
        <location>
            <begin position="386"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI71806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="600" mass="64375" checksum="225DB51E537E0A55" modified="2021-02-10" version="1">MEDVPGWNAGPPRRQQTSRAAAAGLHLAATATSPSPLRPSRSLADLRTPTIDEPPLPPLPPRFYNPDLPPSPPPPYEVRRAQSSSALSLDALLIDAAEPDAPPKKKSTLGQRMHFTMTGLINNPVESSSHYSVIRHSWLPVIYNGPDTSVSVTILSDAPLPSNRTLWLRQKGLLGNMGMALQAMTSLRSDWIEVTPAQEAQVKHIPDQKECVIQRDLERFTRKARDKHKRHVPRETHIVRIPAAATDGYYYLVVCGGKDATKVLCRCPVFRVASMSQDAAVVRGASLSTLPLEIGLKVASTVGTLVAKKYIGVAGVVAEKSAGKYMAKQSVKKAATVAAKSYHGLGGPGIQHVVKDSWRRQRAAGVTAGYTTELAVAVIGPDDGPEKPFPVKFEGAVERGTGSSSAELGFPTANLSGVPDAVRTPLSGVFAAWARLLPGGRNVPDGLSPDWHPAVVTIAPPRGAAPAVAPKNGVRVHVLHDFDDVAFFGGKLAVLLMGWLHPAAPPTAYSTDVVAQHALDIGTTLTSLDRDNWSPERTVARIKALKSERSLSDRLDGVTGKVVQGVDRIPLHRVAVRSQSEAMRDQCFGVGGIWIRRGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBJ0</accession>
    <name>A0A7D5ZBJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Pigl</name>
        <name evidence="4" type="ORF">G6M90_00g105620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541549.1">
        <property type="nucleotide sequence ID" value="XM_014686063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBJ0"/>
    <dbReference type="GeneID" id="26245799"/>
    <dbReference type="KEGG" id="mbrn:26245799"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="304" mass="34516" checksum="902146E28D777FE5" modified="2021-02-10" version="1">MVRKLTNAVQPISRACHWLVATRVRRRWFLRIALIVCLFPLFLQWFLAYMVGGDARLLPPELSKAKNLLIVTAHPDDECLFFSPSILGVLDRNKSIKGGLVVMSTGNNYGLGETRKTELLGSCGALGIDKSRCVALDHPDLQDNPKVWWEEAKIKPILKEYIEKWDIDAIITFDEGGVSGHINHRAVSSAVNQYVAENEKAPASYMVVSVALPRKYTFLLDLPLTALSFLWRILAAVFFPSSSAEPKYSARALITNTWHRYRMTRRAFASHGSQYTWDRHLYMIISRYVWFNDLRRIVGTGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZD62</accession>
    <name>A0A7D5ZD62_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-factor-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STE6</name>
        <name evidence="11" type="ORF">G6M90_00g095400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546790.1">
        <property type="nucleotide sequence ID" value="XM_014691304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26241213"/>
    <dbReference type="KEGG" id="mbrn:26241213"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="52"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="375"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="804"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1123"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1382" mass="150875" checksum="4369A6AACE8B6E07" modified="2021-02-10" version="1">MEPSNPMSGTKSEPSLDSLQVCPSSNVSSMTGYSWKQLLFFTRKQHIGVFSAALGAAALVSALRTLLSIVLGRVFDIISQLGQGARTGQIALADVSTWCLVLVGLGIGSWMVNSSFLGLWIIFGELQAREARRLVFTSLLSKRPEWFATLHDGVEGLHIRLHTQIRDLQLATSQVLGFIISDIITSCSSLAIALYYSWKLSLVLLTTLPVSFIILCIVTRNVDAEIWLQKQHLQKASTSAAAAVNGIDLVTVYSGHDREVSKYALALKHAARHFLIQLRCNSIQAGYIAFWSISVFVLGFWYGLVLVEQGMPPGNVVTTFYAILTAFQGIEALVGHWLVLLKGKGAVYFLSGLAKSEGSLEAPSAKNHQEIIGDVRLERVNFAYESNPDNNCLTEASLHFPAKNMTFLIGDTGSGKSTICALIANLLKPVSGKVLFDGYPVDQLCQSCLRGQIALVQQNSPVIHDTFFKNVALGHTYPSEVTASDVSQACGFAGLRSLILNLPFGLSTVISSDGHILSGGQRQKLALARAWLRDPAVLVMDEPTSALDPISKSEFMTAVRGWRQEKTTVVVTHDLSNIEDQDFVYILKNGSVFRQGQMQELRDVATAFCNSEIKGPSNHRRSRDSLTSNSTTTKQTSQSSDAYYSQFPTVSPQNMPSLTLSAKIDSCHDRRTSRADCRESVTRPPSTCWQLPSDCEGTKQQFSNYLDRHFETPGANSELLHKDWAFGLKDTQTSVTEKSVRRQCIEDDVESTYTKKESQDDSISAIDGLSENNYGPFNRRVASLLGIVSTVWPSIANRDRVALIFAIVLCLVTSAATPAFSYCLSRLLSAMWAKTGKEEGARWALYLVAVAVIDGLSTGGAHYLFDRLSQTWVDNLRKQAFRNVLGQSRSWFQRTQTTSAQLSQCLDRNAQEMRSIVGKAIPAAIIVVALISISIIWAITICWKLTLVTLSPLPLIIFAVKAYSVVSSTWEQRCNDTATNSSAMLKEALINFEFVRVFALESYFSGKQSSAADEALHVGIKKSLYTGPLFGLYQSVIMPLTALVFYYGTLIVATDPRTNVDEILQVITLLLFCIGNTFELLNNLPELAASKQAAADFLEYVQLPKATQPSRYLPNQPSSPLPIQMRNVDFTPDRSSPKILDGLSLDINPGQSLAIVGASGSGKSTVLSLLLGVNTPNQLSQNEAEVDRFGLSFGNVPLPNIDMECLRSTMAYVPQKPFLFPATIAENIAYGIQSASSQSLQESVIQAAKAAGIHEFIISLPNAYETVVGDGGQTLSGGQSQLVNIARALARKPKLLILDEPTSSLDPDSAATVRSATLTLIRSAQRKTRGMAVVVATHCVKMMQVVDEVVLLDAGTKVDQGTYTSLVANRGPLRRLVRYGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZEF6</accession>
    <name>A0A7D5ZEF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">25-hydroxycholesterol 7-alpha-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g111920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540264.1">
        <property type="nucleotide sequence ID" value="XM_014684778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZEF6"/>
    <dbReference type="GeneID" id="26246858"/>
    <dbReference type="KEGG" id="mbrn:26246858"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF8">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60685" checksum="87AA22C0E95AD392" modified="2021-02-10" version="1">MNWPLSNATLGSAMRVFFESVAGKIAIAIIILVICQRMICRPKKHNLFPVYATIEIAVASYILRGDGLGRRIFSSVRRYGGSLFGITSTHQILVNLPGLDRFMSQSFHTLTVVPVQYTLLARVFGAVDSPDLEVKLEKSFKDLLAPVERLFLNDAAVTAAVEKARVEERAASFVTFSTDPAHMKRWERAADIRVIAPGPGKRAVVEANLQSLARDFGACMAIPLLYGEDFLNRYQQLLEDFWLFDNGFFPLLMIGVPPWAPFKAIKQGRAAQARILREIEALYRRIDQYQRGEDVDFGADMSDVSSAALGRNRVYARDGWSFAERAWGDFGMLWGQNANTHPLLFWLLIYVYSTPGLLGRIRAELAPHVCLSRANSPEIMSTDLAALSRNCQLLKASIFETYRLVNEPTSIRYVAKPTTLNDGGIKHKLPSGMFISAPLSLINRDPLVFADPERFVPERFLEVDSESGKSVARYGRLQPWGTGPSMCKGRTFAEREILSLGAVIISIWDISPASGVWELPAMIPGTGVKKPKRDVRVLISRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPT1</accession>
    <name>A0A7D5UPT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">APUM2</name>
        <name evidence="11" type="ORF">G6M90_00g015870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PUF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985614.1">
        <property type="nucleotide sequence ID" value="XM_066129779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPT1"/>
    <dbReference type="GeneID" id="26238385"/>
    <dbReference type="KEGG" id="mbrn:26238385"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="10">
        <location>
            <begin position="411"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="433"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="648"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="685"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="786"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="829" mass="91021" checksum="78316BFEFD5381C2" modified="2021-02-10" version="1">MPPGSNDKSQHQQSMGSGFPGSNLYPNSNIWTASISNARERSIGSKETEGSPSGSSALAANSEADVWGASGPWKTEHPARSVSTSPNRTRDAAISNGAAYFDHTPSAIGVKKGSFGSGHTLPGDASAYSSTSAFTSQKLPAMDALYMEALAQFPGVQSVSREAGMPPSRQSQGSPAFQQDIYRGHTPSNSIHSQRAIGNHAPSFSTQSANQRAFNLNKQIDDELAYQTSRRLGLDNASSGSNTFNPTSQPFQFNPGSQSWMTEPSSSRYDSSMDTDTMAAQYIKRGSIDRISGSPAFRLESGNSPRNYAVNPDTFPARPSSRDHRSNETERRGVPAQHFTGGFAPSFYPGQYTFANLPPQYAPSYIDPYTQNFRNAMMSGYGIPPVPSAYSLAANLPPVRPSRDQDPGKGVRSVLLDEFRLSNKSNKRYELKDIYNHLVEFSGDQHGSRFIQQKLESANSDEKDQVFREIEPNAIQLMKDVFGNYVVQKFFEHGNQVQKKVLAEKMKGKVVDLSVQVYACRVVQKALEHVLVEQQAELTKELEPEILRVIRDQNGNHVVQKIIELVPRQCIDFIMNAVRGQVTALASHTYGCRVIQRMLEHGTESDKMEIMMELHASAQILITDQYGNYVAQHVIQNGKPEDRAQMIDLVMAQLLTLSKHKFASNVVEKCIEHGTAEQRTSIREQLTTVGSDGTSPLQQMMRDQYGNYVIQKLLGQLEGREREMLVEEIKPQFYALKKNGTSRQLQALEKLLGLGSGGSPSRNDAASAQTDLNSAADTPALTNETSSPQSSSPRSAHASAVSIPAEESGNKTSDELSNMIDLQVREEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPX5</accession>
    <name>A0A7D5UPX5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g018270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548710.1">
        <property type="nucleotide sequence ID" value="XM_014693224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPX5"/>
    <dbReference type="GeneID" id="26238154"/>
    <dbReference type="KEGG" id="mbrn:26238154"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="545" mass="58940" checksum="2397825F4C96553D" modified="2021-02-10" version="1">MASNAAAMFSFAQTEPSTDLLNGQSWGSTSESHHNFQDFPDNGSSHSGEAEDYLFTSGHTTPRGSRLEQAASMDSVWTNPRTTQSSVMAQAMARADSSRSSGSSLSQHAQLSRGNVSAFRNVSHAAATTAGTMAGMNSCLLVAADAHAVSSNAQMYWPEMGLDMNIAAGGGSAGGSGAFAVTQAGPMHMVPAHMHLGPESVLPDNSSPGSWDCFSSSISRTSSPATVDDVWLPSALSPNSSPEIVGDSPRYVEYFNANTEQTSYASLISSERKVSMASDKDTIVPKIEEGVAMPHGYPSRRHGSDGESSARDHRLYKNVTPGPDGLFHCPWEGQTSCNHKPEKLKCNYDKFVDSHLKPYRCKADSCEGARFSSTACLLRHEREAHGLHGHGDKPFLCAYEGCERAVSGNGFPRQWNLRDHMKRVHNDHGSSSGSPPATANGQSAKGRKRKTEVAEPQNGTRKATLKSMPVADSKQVSSKPLLEQWLDQRRAVEDLCRSLSKPDDDRNLQQIGEMQKRLSIMAHMASSFHSTDIRPDTNRRNYTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQE5</accession>
    <name>A0A7D5UQE5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TPS2_0</name>
        <name evidence="2" type="ORF">G6M90_00g005360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985723.1">
        <property type="nucleotide sequence ID" value="XM_066129589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQE5"/>
    <dbReference type="GeneID" id="26245214"/>
    <dbReference type="KEGG" id="mbrn:26245214"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="635" mass="71502" checksum="94C950E2EC32C0BA" modified="2021-02-10" version="1">MGLPGPKGASQSETHLPPHDRPSVVSVPVTPGIGRESYDQDYFERNALQSPSTTPGTDSKVAQSPTISRKDARPGSSSERRRRPKQNSTLDGNIISVTFTVPHVLEYRQDSDWELRRCYNRSALLDALHHLSDNGPHNHTVVAWTGEIRQAADSNDDAVSDDNLPITPSSTSISLGGNARMQIPPSKNVFVTRADQLRLEQQLHEDDISIVPVWLADENDMTTEGIRLHDQSRWRRYAEHDLCALLHYRQHPPSEPYSEGGRWADYCQMNQRFAQRVIETYQPEDTVIIHDYYLMLLPLLLRERCPDISVAFYLHTPFPSSELIRCLGRRQSILNGILGSDLVVFQSFHYAQHFANTCARILGLEATSRAVQTATRRVRIEVIPMGISIATVHALAWKATAIEKCALLKQQHGGKKIIVAYDPKDRLGGVDKKLLAFDRFLTKYPEYRNRVILIQVMSPTTMEADDAQEADYATGVGELVAEVNRKYGSLDYMPIQLQSQNLSVDEYFALLRSGDVALFTSVRDGMSTTSLEYVVCQRDGHGPIIISEFSGTASSLKEAIHINPWDTDGVADQIYRALNMEEEERRDIHAAVYRRVAERDVRHWATTLLRRLKRAVGARDSRYFGANGLADIGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQZ7</accession>
    <name>A0A7D5UQZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g003990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQZ7"/>
    <dbReference type="GeneID" id="90967412"/>
    <dbReference type="KEGG" id="mbrn:90967412"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF42">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="194" mass="21690" checksum="BC2F12B57EF73756" modified="2021-02-10" version="1">MALDSFRQDFGLADVSVTYRDTLRGNIVSTFQASCLWVAVDFSPRRLLSAEDSSVSLKADQGLWIASQAGDQLRPKRFATGLYDIANTIGMMIFSVWLVEKVARRNGLIWGAFVGSVPMWYIGAYVMRADPTQAAAAGDMNCHGWGLLAMVCVYSYGMVYCATWQGITWVYCRKIFLIDIRMLCTAIAMADQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URA3</accession>
    <name>A0A7D5URA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g020830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URA3"/>
    <dbReference type="GeneID" id="26237908"/>
    <dbReference type="KEGG" id="mbrn:26237908"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="204" mass="23008" checksum="CB650E95D1A3FAB3" modified="2021-02-10" version="1">MTATQGRKYRDEPRRLTSSPAGTDMVERVAYILRYLGTMGLNNFDELLCTYYTQNFHEPSFLCNELRPSHHRRLPGVFSSVFRASENWSIWERRGFQEEVSKATEEALLSESWETQSDIHPAVTHMLKAPKSNLPCVASRVSPLKSCITNKLPHLWTLMMTLATSVKPAGNRDASGAVFAAILLLQYGGRMGRKMLLDLVGLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URI5</accession>
    <name>A0A7D5URI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g028810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="QLI64879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="QLI65155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39701" checksum="E3BDF4A37B7120DF" modified="2021-02-10" version="1">MFPIFLFVAGALGSEMSLLKKQIIQIQPELVKHYTSIVKPLVPPRMWASQAGFYEPLVGAAVKPVCGCTVEEMFQLHDVFFSNITSEVDVDFYPHADSQPLGGDIWFESSTATTDTSTFKWEHNGEFSLEWSFQVAGAGPKVGAKLGYKVGKDNTETKTTTFTEKKRLTCPQGHLCQVQTWSFSASIPGNFFKVPAVDFTCLPACLRWKHKETGLYHELNTTSRVALAGLAGQSATWDALGQKYFELRDEHDKPVSSCPPGGETIVGIQFPPEGVRTVYSQARPHTPSVPIMDDSKKPYQIQIMLDFSRKSFPGETRRDGVVANLTQEELAALKPEDAEVKAYVVGTNIPGLDADTNIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US33</accession>
    <name>A0A7D5US33_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">G6M90_00g012420</name>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="137"/>
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            <begin position="36"/>
            <end position="47"/>
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            <begin position="70"/>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI65376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="20"/>
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        </location>
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            <begin position="205"/>
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        </location>
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            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
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        </source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A7D5US68</accession>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
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        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="135" mass="13962" checksum="304E50FA7D06D496" modified="2021-02-10" version="1">MGLRPAQAARLSRLFVTKAYHTNPISYSPYKDSQDRKSLNPRSAEATKSGRDDDVASAPKAAFGRGVTSPEGERATAAKEEGSDPLEVSGANQELSKPQGDERSGHAMGAGKEVRKGGKSGGGSAPKNGGASKGY</sequence>
</entry>
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    <accession>A0A7D5USK3</accession>
    <name>A0A7D5USK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxidase</fullName>
            <ecNumber evidence="12">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PER</name>
        <name evidence="15" type="ORF">G6M90_00g020080</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 12">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548535.1">
        <property type="nucleotide sequence ID" value="XM_014693049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USK3"/>
    <dbReference type="GeneID" id="26237979"/>
    <dbReference type="KEGG" id="mbrn:26237979"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000021">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029039377" description="Peroxidase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="177"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="90"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI65955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="41618" checksum="1F997C09F43498AA" modified="2021-02-10" version="1">MKATLVIFSAISMANAFPGMSELRHVSRAQDEDNTKKLPGDLEGQDESTMSETGKLIKNILQGNENPQDLTTAYSSVPDQNSAECKADKCCIWKHIADEMKSKMTGDAGRCNNLARQCIRMGFHDAATWSLNTGKDGGADGSLVLARECFDRKVNNGVTDGCNQMQAWFDTYKSFGVSMADLIQMGANVATVVCPLGPRVRSFVGRKDNANPSPDGLLPSPSDPADQLISLFANKTISANQLVALVGAHTTSQQFFVDTARAGDPQDSTPGVWDTNFYGETTDANSPKQVFKFQSDVSLSQDSRTKGAWTAFTGTQGQRPWNGAYAAAYVRMSMLGVYNTNDLTECTKALPLPITSFTFPDAAALADFANGGAPDASRNASNGDIIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USN9</accession>
    <name>A0A7D5USN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">L-threonate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ltnD</name>
        <name evidence="12" type="ORF">G6M90_00g009320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549581.1">
        <property type="nucleotide sequence ID" value="XM_014694095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USN9"/>
    <dbReference type="GeneID" id="26239025"/>
    <dbReference type="KEGG" id="mbrn:26239025"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="entry name" value="Four-carbon acid sugar kinase, nucleotide binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="entry name" value="Putative sugar-binding, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142764">
        <property type="entry name" value="YgbK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="220"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="374"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="544"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase N-terminal" evidence="9">
        <location>
            <begin position="743"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Four-carbon acid sugar kinase nucleotide binding" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1190" mass="125845" checksum="16C674D752EC1D1A" modified="2021-02-10" version="1">MHTIHYRPHNFFVSRNGKQVQVGETRTQAGQMMPLTASKPDDGPEPVSPANIGFLGARGWSLPLLMGAVSKPELRVHVYDDASDLVPRLAELGAITKDSLVKVARHCQTIVCATSDIKELESHLFCSQSGILPALPKHSIVLLSPSSPPSYYPYLLRRIADEGRPDVSLLDAACLAKSSHGNHHGRNVLVLSGPAGALAEANETLRGIPVQIWPIPGGLGQASKVEMVNQLLTGLHAAAAAEAMGLAAKAGQNTQVTFDIISNAAGTSSAFESRVPHMLSGDWKSQASTWQRTLDSLKSAISTARKLHFPLPLTATVEQLFISGVSQGLGNDGDGALVRAYLPECPDLVKDKAGQRSVNTSSHAPCCRAGDVSKIGFVGLGAMGQGMAASLIRAGFVVQGYDVHSPAVEAFASLGPGAMSAGSPGEAISGSDAVLLMVQNASQIDDVLFGSCRGAAALSSGSVVIVSSTVPPEHVRNVNLRLKEMGKGVLLVDAPVSGGVARAANGTLTIICSGENEGISKARGVLLAMTGGEKNLCQVEGGIGMASSVKLINQLLAGVHIAAAAEAMAFAARLDLDTQIVFDIFKASSAWSWMFENRVPQMLNGDWTPHSALAIFVKDLGIVLDEAARLNYYAPISSAAHTLYLAGAGHGWTNESDSGVVRLWEMLGPSVKSKADEKLDKPNSQGVEDQAKRTSIMNPGSDNRKGPQRLPAAPTLASLPPEYPHDVLSSIQGVVGSDQVPTLVILDDDPTGTQTCHDIDVLTVWDSETLDSEFRLDPRGFFILTNSRALPSAAARELIQEICANVAQAAKRAGKAFEIVLRGDSTLRGHLPEEPEAAEAALGAFDGWIISPFFAQGGRYTIDDVHYVKEGDTLVPASQTQFAADATFGYQNSNLRQYILEKCGPRFNNDSFLSITLQDIREGGPKAVTEKLLSVGPDSNRVIIVNAVAESDMHVFVAGLLEAEKGGRRYLYRTGAAFVSSRLGIKGIPPLTMKDLGVFSGAGERRPGGLVIAGSYVPKTTVQLEALTQRLKAKLQVVELKVPDLIASEDAAESIVRAAAQAVSMKLYAGHDVLVMTSRALIKGHDGLSSLNIGSKVANALVQLLGLVDVHPRYIIAKGGITSSDTATKGLKMKRARVLGQAAPGVPLWRCDEETSRHRGVPFVVFPGNVGNEDALADLVEAWAMPEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USU1</accession>
    <name>A0A7D5USU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g020590</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548487.1">
        <property type="nucleotide sequence ID" value="XM_014693001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USU1"/>
    <dbReference type="GeneID" id="26237931"/>
    <dbReference type="KEGG" id="mbrn:26237931"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="137"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22897" checksum="61A5CC73D3E23B86" modified="2021-02-10" version="1">MELSTQEPTHPPHPAVNEAKRPQVQPWVHLLAGAAGGMVTAIITSPLDVLRTRLQSDLYASPAHDSKSGLSSFKSPFRHVYDTFRTIGTIRGREGWHGLFRGLGPSLAGVVPATAVKFYVYGNCKQLSVQYLGFRSDEPIVHALGAVAAGLATATVTNPIWFVKTRLQLDMSQSHHGALMRQYSGSLDCIRQVVRSEGIRGLYRGLTASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USZ0</accession>
    <name>A0A7D5USZ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g008140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549693.1">
        <property type="nucleotide sequence ID" value="XM_014694207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USZ0"/>
    <dbReference type="GeneID" id="26239137"/>
    <dbReference type="KEGG" id="mbrn:26239137"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="115"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55258" checksum="1F75B6987146853E" modified="2021-02-10" version="1">MEKFPDHVDAPRFPNGISRSPSPLKPASGYGLPNGAISHSDRRSTPAARKENGHTQAAVNGHGQNLSPWSEDSKRGHGRQKSLSDAFRTIRTRKGSVSQNAHEIADALRAPVSPRLVILCLMWYTSSALTNTSSKSILNAFDKPATLTLVQFAFVSSLCILLAWLATLFPILREKVSALRQPIRQPSRDVLMATLPLAAFQIAGHLLSSTATAKIPVSLVHTIKGLSPLFTVLAYRIFYDIRYPQATYWSLIPLTAGVMLACSGKHSYGGQMLGVVQALLATLIFVTQNIVSKKIFNEAAKAEAEGPGVQSKKLDKLNLLCYSSGMAFVVTMPIWFWSEGITLLKDFLHDGSLDLSNKKDAMDHGRLTLEFIFNGVFHFAQNILAFILLSMVSPVTYSVASLIKRVFVIVMAILWFRSPTTPIQAVGIALTFVGLYLYDRTSESNRADRKARLMTESRIASPLLPLEERPSRPASGMNGVTTQPYDRGYLSSFSGGNSSKRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT28</accession>
    <name>A0A7D5UT28_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase family AAA domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ATAD1</name>
        <name evidence="7" type="ORF">G6M90_00g008060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549702.1">
        <property type="nucleotide sequence ID" value="XM_014694216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT28"/>
    <dbReference type="GeneID" id="26239146"/>
    <dbReference type="KEGG" id="mbrn:26239146"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="734"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113036" checksum="9E5EF64E496D935D" modified="2021-02-10" version="1">MQTPILKALPATIVVTARASRAPSLRAFHSTPHRRSGNGSVPGGKPSDDSITEHDNEPELQPATETTGGRARNQTPGALKNRLARRRAASALPPVELPSSFLNNNVSLYSVERLPRLPVALVEDATREKTSRLFQGHTSLSRQKHQTLQSYFDTALTTLLLRDCELAMDFERSKAHDKGRHWNTSASIQSVVRIWDMILDSAWHIVDCIYPARQPEYTYKVRPFWWWDIYKHLDQRTQNSRDQLLALTLSLDERLGHAEQLAYPLSHAVADLPVDTLLSIHHAVKRDLQALPPTVFDAKSSKRPITILSMSGYGGKSISQAVGEHLAFWNDADLIHLDAQDLSVLVGDYLGLNWAYSRGAVSMMGFRAAELNGKLAKEPGDNSRLSEEDDHDAEAGIIGLRASTGSLDDDLQKIRHGEYDCFSKWENLKIDKILDHIIRAPELKAGSQTPQRPILIHLHDIVELSMTLEGSLLLGRLRTLVDTAWHQGMKIAIVGTSSSEKSSEEYQNAVSQFAATDWVITRHLEADRVERRTVAKASSGQARFSLQKADYFTENICNINRMLRALSPNDSPVVVELSNDNVIAYLHSGNPKFSLLRDSILPIPEVYHLACAFRALDDQNPGTGPIGFLERCVMGPLRQQPGQRFLDKDDSEMDIEADTNHQSREEPKSDGRIGMKLNEYEKRISSGQINRENLRTTFEDVHAPKDTISALKLLTSLALVRPDAFAYGVLSQDRIPGCLLYGPPGTGKTMLAKAVAKESGANMLEISGATINDKWVGESEKLIRAVFTLAKKLEPCVVFIDEADSLLANRSMFSNRASHREHINQFLKEWDGMEETNAFIMVATNRPFDLDDAVLRRLPRKILMDLPLNADRAAILRLLLRDESLDGSVSLDDLARKTPYYSGSDLKNVCVAAAMAAVEEENEMAAKHEGPEPYHYPERRVLRRDHFEIALKQIPASISEDMTSLKLIRRFDEEYGNGRRQKKKASMGFGVLEDKGHANGSEARIRSTISAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT65</accession>
    <name>A0A7D5UT65_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g035070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986151.1">
        <property type="nucleotide sequence ID" value="XM_066130164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT65"/>
    <dbReference type="GeneID" id="90967613"/>
    <dbReference type="KEGG" id="mbrn:90967613"/>
    <dbReference type="OrthoDB" id="3598799at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7225" checksum="E3DE927DC26DC477" modified="2021-02-10" version="1">MAPLTRKRKLLKHDEIEDTTVADSDLEHDASTALPSLLKCTGGKNPRTTLSQDDEASLPLQTRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTR0</accession>
    <name>A0A7D5UTR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g037940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547154.1">
        <property type="nucleotide sequence ID" value="XM_014691668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTR0"/>
    <dbReference type="GeneID" id="26239717"/>
    <dbReference type="KEGG" id="mbrn:26239717"/>
    <dbReference type="OrthoDB" id="5229455at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="35698" checksum="9BB5DAA3B4BD0978" modified="2021-02-10" version="1">MSHEYDFLIHSMLGLGASHLSLLAPGDFNQSALQHRVTAIERLNKFLSRPALSLLDTEAAFAAILTLTFQAAHMPDGLTDFLTMTRGCFLVGTHVVPDLENSAFKTFERDVYVEKASSVAASDNHWLPLLDKSIANGFCTSLEQLGPLCHSVIDIEHIAMMRRIVISATNNIYECFREHSFLHEKAGRLSAVEFAAFIDPSNHIARLVIVHMLLLDIIMSRTICVWEEGPQFSFHETRHRYDARNVMAIVWMEKIYDSLPETYQPYIEWPLKFSRFMKTTFQADTSFWRLASVDLHDDIGLETLRLEESEICE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUA1</accession>
    <name>A0A7D5UUA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g033670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543294.1">
        <property type="nucleotide sequence ID" value="XM_014687808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUA1"/>
    <dbReference type="GeneID" id="26244095"/>
    <dbReference type="KEGG" id="mbrn:26244095"/>
    <dbReference type="OrthoDB" id="3162605at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="GmrSD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094:SF15">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24094">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="GmrSD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028847241" description="GmrSD restriction endonucleases C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GmrSD restriction endonucleases C-terminal" evidence="2">
        <location>
            <begin position="102"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="210" mass="23380" checksum="136866728457B9B5" modified="2021-02-10" version="1">MKIVTFSILFTAVVVLAAPVPEPTPPGIPSASSARTTLASLQVSTPVDDGTYNRSLFHTWDIIHGKCNTRHVEIPDVVLIRDGEDVKTNRNCVPQSGIWTSPYDGLVFTEAHKLDIDHFVPLKNAWMSGASEWTDEQREAFANDLTHPQLWAVSAHANRQKGDKSPDRWKPPLTSFYCTYAESWVDVKGYYNLTISDSEKDALGSMLDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUD2</accession>
    <name>A0A7D5UUD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual serine/threonine and tyrosine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DSTYK</name>
        <name evidence="2" type="ORF">G6M90_00g052100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539404.1">
        <property type="nucleotide sequence ID" value="XM_014683918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUD2"/>
    <dbReference type="GeneID" id="26247804"/>
    <dbReference type="KEGG" id="mbrn:26247804"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF289">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE VIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="29123" checksum="2E9D2D00498A2D58" modified="2021-02-10" version="1">MVYGIDEATVLKEYFDETDQGVAIERRAFDRLGLHRNIVQCLGEPNNKSIILERGQPLSNVTGTKSQLEQKLQWIRDAAEGLRHIHRSGIVHADFGCTNMILVEDRVKVIDFGGCSIDGSEALAGYNWYNRRGSMCPSLETDIFAFGCAVFEILTGKPPYHELKDCLERDETVRQLYAEQRFPAVDQLPLRELMLGCWHGTLGSMDEVARCIDAACTVHQGIDSTASIITHLISKMRSCFRSTSLAVTRQLEGRIGQSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUN5</accession>
    <name>A0A7D5UUN5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OpS6</name>
        <name evidence="9" type="ORF">G6M90_00g044990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544659.1">
        <property type="nucleotide sequence ID" value="XM_014689173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUN5"/>
    <dbReference type="GeneID" id="26242000"/>
    <dbReference type="KEGG" id="mbrn:26242000"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="221" mass="25084" checksum="4362691864DAB55E" modified="2021-02-10" version="1">MASLKTMTLHSHAGGPNPWKVAIILEELGLPYEHKFLDFKQVKEEPFISLNPNGRVPVLEDPNTGISLWESGAIIDYLIDTYDTANKLQYTSTPEKYQTRVWEHFQMSGQGPYFGQLIWFTRYHPEKLQSAIDRYAKEVRRVTGVIDAHLKKQKTEYLVGDKLTYADLMFVPWAVAVSSMAGDLLDLSGYDAYDAWFAKLKSRPSAAKIIKEREAALAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV57</accession>
    <name>A0A7D5UV57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">mpg1</name>
        <name evidence="17" type="ORF">G6M90_00g038080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547167.1">
        <property type="nucleotide sequence ID" value="XM_014691681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV57"/>
    <dbReference type="GeneID" id="26239730"/>
    <dbReference type="KEGG" id="mbrn:26239730"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="16">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI67233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="364" mass="40342" checksum="0275C19DDCEB6C58" modified="2021-02-10" version="1">MKGLILVGGFGTRLRPLTLTLPKPLVEFGNKPMIVHQIEALVAAGVKDIILAVNYRPEIMEKFLQEYEEKYDINIEFSVESEPLDTAGPLKLAEKILLKDDSPFFVLNSDVICDYPFQDLLQFHNNHGDEGTIVVTKVEEPSKYGVVVHKPNHPSRIDRFVEKPVQYVGNRINAGMYIFNTSVLKRIELRPTSIEKETFPSMVQDNQLHSFDLEGFWMDVGQPKDFLLGTSLYLSSLTNRGCKTLTPPTEPFVHGGNVLIDPSAKIGKNCRIGPNVTIGPDVVVGNGVRLQYCVLLRGSKVKDHACVKSAIVGWNSTVGCWARLENVTVLGDDVTIGDEIYVNGGCVLPHKSIKTNVDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVB2</accession>
    <name>A0A7D5UVB2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g032670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986421.1">
        <property type="nucleotide sequence ID" value="XM_066130116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVB2"/>
    <dbReference type="GeneID" id="26243999"/>
    <dbReference type="KEGG" id="mbrn:26243999"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37472" checksum="4F10BEE25BAFF946" modified="2021-02-10" version="1">MKSQVFVLGPGYVGREIIDLLLSEGQYEITTLVRREAAVEEFEKDGVKAVLGDLNDFKVIQQLSAKSDVVFHTATADHLESAQAILAGIEERAGQGKKSIYLHQSGASVLSDTSPGNNVNDEIYSDKTPSQIDSLSDTAPHRKIDLAILKAREKMGNKARIFIWMPPIIYGSNSKHKRLSIQIPALTRFACKHGQAGYVGTGKKAWGVVHVRDLAKAYVQVLHWIEGAADSDPELQNPYFFCESGQVTWAEVGAIIGKGLYKASRITTPDTRSIPESEYVDLFGQFTPDVVGCSCRNRADRLRSMGWKPEQLGIGEAFEKEDLPALLAEKGEFKASEMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVB5</accession>
    <name>A0A7D5UVB5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g043160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547650.1">
        <property type="nucleotide sequence ID" value="XM_014692164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVB5"/>
    <dbReference type="GeneID" id="26240213"/>
    <dbReference type="KEGG" id="mbrn:26240213"/>
    <dbReference type="OrthoDB" id="10287795at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="103" mass="10963" checksum="F7D3339ADEE3BA95" modified="2021-02-10" version="1">MAAKDCLRVSDAATIVQRYRNVLAGGDGRRPYQLDNKFIVSVLCRLSRPAKKGSGSHSMPSNVDHSEPGTTPSVDPVGVDGRSSRTRIIPAADGIDGQQQSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVI2</accession>
    <name>A0A7D5UVI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">sec31</name>
        <name evidence="19" type="ORF">G6M90_00g049990</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545106.1">
        <property type="nucleotide sequence ID" value="XM_014689620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVI2"/>
    <dbReference type="GeneID" id="26242447"/>
    <dbReference type="KEGG" id="mbrn:26242447"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="18">
        <location>
            <begin position="551"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1109"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="479"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="846"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1048"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1080"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1099"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1248" mass="133350" checksum="2409B8428F8BFCF0" modified="2021-02-10" version="1">MVRLREVPRTATFAWSPGSGKPLLVTGTRAGAVDADFSDESKLELWDLSLDDQLQGLELQPLASITTESRFYDIAWGSADSDHPKGIIAGALENGSLELWDAAKLEAGAPDALISQTNKHTGAIKALQFNPLKPHILATGGAKGELYIFDVNDIENPFRLGNVAARSDDIECLAWNRKVSHILATGGAGGFVTVWDLKTKKASLTLNNNRKAVSAIAWDPNNSTKLLTATPDDNTPVLLLWDLRNSNAPERTLQGHEQGILSLSWCSQDSDLLLSSGKDNRTLVWNPQTGDKYGELPEMTNWTFQTRFNPHNPNLSATASFDGKITIQTLQNTNPDTSQTPAEKNLDGEEFFRAAQTQPQGASWSLNKAPNWFERPVGATFAFGGKIVIFKANPSQPGQKRSSKIAIAKFSADADVSDASAKFQTALESGDVAAICEERASQAHTEEEKADWKVIETLAGDNPRGQIVEYLGLQENELVNGESKADADADEKKTDSKADEEGEQKSKEVSDFFGGDEGDDFLSSVAATKGAKTDNPFHLFSDGDTSVEKNITKALMLGDFAKATDICLKEQRIADAFLIANCGGQELVDKVQTAYLSQKSGMPSYLRLLGSVIAKNLWDVVYNADLENWKETMAIVCTFSDPTEFPDLCEALGDRIQDGGSRKDASFCYLVGSKLEKVVSIWVAELEEAEKAGMKEATGGSTFSVHAKSLQNFIEKVTVFRQVTKFQDSEQSQTSDWKLATLYDKYTEYADILASHGQLEVAQKYLDLLPSSYPAAEIARNRVKLATKKPAAQAATRQTTTRQATSSTASRVQQPTLGYGTPQPATTGSPANPYGGLGQPHAPVTQTQQYPPQNQYQPQGYQPSMGYQPTTQPAYGGGMVPPPPMAGGPPRSSSSTPSAPPPNRAKSAENWNDVPLVTKAMPRRSTPVAPITSPFPGSTSPTAGSSAPPTGPPPPGGYGHATSAVPPPPRGAAPPRVQSPLTGQTHGIPPPRPSSTANQYAPPAPQPGAVPSPVPQVVPRTASPYNAPPAGAPPSNRYAPSPAAQRPNQPPTSAMPPPPSAGSRPPPPANPYGAPPQQTPSPGQYAPSPYAPQQGQAAGPPPAGRPPSGPPPSNLPQATPPPPKAAAPPAKAKHPAGDRSHIPAHAQRLVDVLSQDMQRVAAKAPATFAAQVNDTQKRLNLLFDHLNNEELVQPATIDQLTQLADSIQAKDYAAAQKLQVEIQRDKTEECGNWMVGVKRLISMSKATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVK0</accession>
    <name>A0A7D5UVK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Bifunctional cytochrome P450/NADPH--P450 reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CYP505A3</name>
        <name evidence="18" type="ORF">G6M90_00g040140</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547364.1">
        <property type="nucleotide sequence ID" value="XM_014691878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVK0"/>
    <dbReference type="GeneID" id="26239927"/>
    <dbReference type="KEGG" id="mbrn:26239927"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="14 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI67897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="457" mass="51357" checksum="44F8990FD7374045" modified="2021-02-10" version="1">MPQPIPRPPGVPLLGNIFNITPSNTWASLNKLSEEYGEIFQITVLGHTIVFVGSVALAEELCDQKRFRKYVGGPIVEIRAAVHDALFTAFENESSWGIAHRIIAPHLSPEALGQQNFTEMRDLANELFAKWKNLEANTVISPLSELQRLDLETVTLTLFGQKLNCLEGPEHPMLKGMEDSTSEAMMRPTRLSLVNWLVYRNKFNKSIQTMRRYAADVVEHRKDNPTTRQDVLTAIMNNEDPETKKKLTDSQIIDEIVSMPIGSSTAPCLLTSAILLLLRNPDVISRARREIDAVVGAGDISIEQLDELKYVQAIVHESLRLSSPAPGFNIEPLPSDSKAPVQLAGGKYQVAHNQPMIIVLAGVNRDPTVFEDPLAFKPERMMGEQFERLPDGAKKWFGNGKRECIGKHHAWQWSVLVLAMMLQKVDFEMADPEYTLEKDGWFNVRPVGFKTKVKPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW52</accession>
    <name>A0A7D5UW52_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g035170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546911.1">
        <property type="nucleotide sequence ID" value="XM_014691425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW52"/>
    <dbReference type="GeneID" id="26239474"/>
    <dbReference type="KEGG" id="mbrn:26239474"/>
    <dbReference type="OrthoDB" id="10261104at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36437">
        <property type="entry name" value="GLYOXALASE/BLEOMYCIN RESISTANCE PROTEIN/DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36437:SF2">
        <property type="entry name" value="GLYOXALASE_BLEOMYCIN RESISTANCE PROTEIN_DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="108"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="236" mass="26211" checksum="4E98374B6EA33BD2" modified="2021-02-10" version="1">MPEVDALDSSLAITPNGNSAGQSPPRELNVPMRDVSRKSSNTHKARQAKQNPSATLQNRGGLTVDAYVNDASSISNRGKPNFQLLTHNSSSQPQKKPSDAPPTTMRCHISHVALVVKDYDEAISFYSKLHFTLVEDRFVPAQSKRWVTMRPPGAGPDAATIVLQKANTEEQLAAVGNQSGGRVFLFLETDDFDRDYRSMSQAGVEWVREPVVQEYGKVGVWRDLYGNQWDLIERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW53</accession>
    <name>A0A7D5UW53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547116.1">
        <property type="nucleotide sequence ID" value="XM_014691630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW53"/>
    <dbReference type="GeneID" id="26239679"/>
    <dbReference type="KEGG" id="mbrn:26239679"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="71" mass="8061" checksum="77373BF1A84B14C6" modified="2021-02-10" version="1">MSEAYERERQNDSRLNELSAKVSALRGVTVDIYDHARAQDVIDNTVWLLPHAPPMKKDLNPSRSTSNEPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWL3</accession>
    <name>A0A7D5UWL3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ELM</name>
        <name evidence="4" type="ORF">G6M90_00g052830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540409.1">
        <property type="nucleotide sequence ID" value="XM_014684923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWL3"/>
    <dbReference type="SMR" id="A0A7D5UWL3"/>
    <dbReference type="GeneID" id="26246771"/>
    <dbReference type="KEGG" id="mbrn:26246771"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029016748" evidence="3">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="283" mass="31367" checksum="09C3C55EEAFD9C50" modified="2021-02-10" version="1">MRLYFLALALTAAAAPKSLAAEEHVAKFGDTRPISNDPRPVSGTVVPRQQPDGTEEVGFDVYVHVVGRPEETKANQTEFLLTRDDVKSQMEVLNRSFKPVGISFKLAGVDWTAISTLAPYENPFSNILYNKELEGIYKGDDKGDNTTLNLYFLNGTNGHGGISQNFFYLKRFVFVNARTVPGGTEPSFNMGLTTVHEVGHWLGLVDVYKVKPSWGTAEDFSKARAACLKLDGPCDTQVECLNYMSYASDTCKNEFNPEQIRFMKTYAKEMLAGGTPQPIEIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX22</accession>
    <name>A0A7D5UX22_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA-intron endonuclease Sen2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g063270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542556.1">
        <property type="nucleotide sequence ID" value="XM_014687070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX22"/>
    <dbReference type="GeneID" id="26244505"/>
    <dbReference type="KEGG" id="mbrn:26244505"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="9">
        <location>
            <begin position="435"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="562" mass="62453" checksum="9AC5608087746806" modified="2021-02-10" version="1">MAEIQQPPKENGQVMAPPAQASTKSANSRKRGPPAHQIYALPAPIRTFPLPAFYPNNPLSFFAVAYAWLRQVFAPPPAEPAVVHQGVWSKKTFSVHVTDEKSMRALWEQGFYGKGSLSRSEPNWLRREQVRRGMQETHVSEILTVQRREERAQAKWERARLEQEVIRQTRLKEAQQAEDNSQSKTATMQLSPSPVIFAAPTGPIELLSLPNSAAEAFEKPEVVSGTVIAVRAATEAVMMPLPVDIAPPSILETGNGIIDTNVVSTASFVADSPRVRGQSSGSGVIETPHPPASETSSDSAEDKTLKRQKSVRFSPKVESTTFDLADPPNPYHSLNGKGKRLLLNGGIDGSDTAEEAKKLSADESEDIIVNREHLQLMPEEAFFLTFGFGALSVTDPASGKSLTTKEMLTLFRQYSYFPPRTGCPDEPELGPDDGFLVHYAVYHHFRSLGWVPRAGIKFGVDWLLYTRGPVFDHAEFGLIIVPSYSDVWWKDRGKQGPQNTWPWLHSVIRVLSHAVKSLVLVYVDIPPPPKFDAALETGFAEALQLYRVREVMVKRWSSNRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX83</accession>
    <name>A0A7D5UX83_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RNASEH1</name>
        <name evidence="10" type="ORF">G6M90_00g064660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986731.1">
        <property type="nucleotide sequence ID" value="XM_066130782.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247114"/>
    <dbReference type="KEGG" id="mbrn:26247114"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="68"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20826" checksum="3AA614E0A9689A31" modified="2021-02-10" version="1">MGIRRHPTVTDHADWSSQESTRDRKYVPSKLYGQNVNLSRVEVGDECWTYVACDLDEPCKNCGRLSVHIDCIVIAVDGAYWNNGTLKAKAAAGVFVGHKSTFYDGFILNVPNPTSQIAKLRAGVRGLEQGLAIESQGVEDENLRKVVIKADSEYLVKGMTEWVFTWKMNGYQTSRGAAVANASLLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXC8</accession>
    <name>A0A7D5UXC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g045550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986488.1">
        <property type="nucleotide sequence ID" value="XM_066130391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXC8"/>
    <dbReference type="GeneID" id="90967714"/>
    <dbReference type="KEGG" id="mbrn:90967714"/>
    <dbReference type="OrthoDB" id="4941169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35074" checksum="31307B34595BA7E4" modified="2021-02-10" version="1">MQLDERKESIIAAVSDELARFKLWSGNIGAHRTGLGSLDHRLRDASPLRQQVARLLDELTSSIDEVEATWSGKATPWDEEVIDSCDNDAELKEILGDEKFEFDSELAQLSVDIADIINSLLRLSTSIRNPAPHDHFMSTEYAEDSYFSDFDVRHVEAKYKDANKDLVRRLGKAISRRRRYFKYRESHHAKLSQGLELDQGCTEAGEKSTVASSVPLAMKDPGNSEPLFGELDEDDHSETGNSQTSYATTAPESEKLRVPPLPFAQWRLVQRNVSLMKLVRQHVMSDLRPYMCLLENCLTADKEYSTRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXI4</accession>
    <name>A0A7D5UXI4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase MRP protein 1 RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g058070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986855.1">
        <property type="nucleotide sequence ID" value="XM_066130658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXI4"/>
    <dbReference type="GeneID" id="26242796"/>
    <dbReference type="KEGG" id="mbrn:26242796"/>
    <dbReference type="OrthoDB" id="5414547at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22573">
        <property type="entry name" value="RMP1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047205">
        <property type="entry name" value="RMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047204">
        <property type="entry name" value="RMP1_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37792:SF1">
        <property type="entry name" value="RIBONUCLEASE MRP PROTEIN SUBUNIT RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20945">
        <property type="entry name" value="RMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase MRP protein 1 RNA binding" evidence="2">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="248" mass="27643" checksum="4AE8593402B3D21C" modified="2021-02-10" version="1">MTYQNQPSEPQQLRKPPYSAPAYPGRPQATNHPHARTTLNTILPLLDAFNHRHHNQHRTSHWWATFGILRRSLRALAECLDQPVVDSSRNRTDQAVVRASWLNTHALPRAFLAFSQLAADNQHAPLGLFLLTVLSQVHGFLPAMLPQNAGAAKAKLPTQKSPNPPSPNHRSVIGTEHIDRGVVVSRETIVQAGDDAVDPRSKKRSRDEIKSHARGTSNKDSEKDKDKKPRKKKKKAGDELSSLFDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXI6</accession>
    <name>A0A7D5UXI6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g064030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540138.1">
        <property type="nucleotide sequence ID" value="XM_014684652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXI6"/>
    <dbReference type="GeneID" id="26247174"/>
    <dbReference type="KEGG" id="mbrn:26247174"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="99"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="27855" checksum="8F86DC9B41EFBA53" modified="2021-02-10" version="1">MALQPCRAHFPRARCALRALMPSLRTYATESTSEPFKASSQESSVPRWSQTPPGMKAPMQLDFAKSFKNKVWKVNNDPAKLDNMYNRLLGPGGSKMLPEELKWLAVTHKSFDQGRRGFNDKLALLGRLTLVMEATKEIVSKAPLPGSRQTDEFDRVPFEHEQLASVDNLSVEEPKDVVSKEKLFSLASDAGILDVLRWKPRLPKSLESSGVEVVVNSAVLAILGAITLQHGSVVASKVVRERILARLSKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXP7</accession>
    <name>A0A7D5UXP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g062160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542659.1">
        <property type="nucleotide sequence ID" value="XM_014687173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXP7"/>
    <dbReference type="GeneID" id="26244608"/>
    <dbReference type="KEGG" id="mbrn:26244608"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="392" mass="43164" checksum="A11F2DA95EE98C30" modified="2021-02-10" version="1">MSAQISFLDGTYTLIHIPLDLYTTFLQPILRVLIPQTARLHLGADFKPDVDELDGLSEENQHGFLNISVTPLEASIVCHTSWAKEVFEPVINSLPAQKAKTVSVFTDSYMVLSVIGAGLDAATRVLELSSPLALAGIPIFFITTYYSDFILAPTRERQNVIAALCEKGFEMSENQSNSVTSPTYSRKNSESHHSASPPSTPPPSTDNELQLRTFDLLHKRSVAPYVDEDLELVQCSGREISQLADAYGHRSSISRHTVTDNRQSWIENVDTKLYASLISVLISQPRFISITLAHEDPPSLLMDKNLLGLFSDSLVGDMDNILIPIFLDLLNLSSEVTGIVCGVSGRLVDEMKMTATSELSYLSTARAGVVILPEEQSTRALDILKPLLQKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY50</accession>
    <name>A0A7D5UY50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Laccase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Conidial pigment biosynthesis oxidase Mlac1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lcc2_1</name>
        <name evidence="17" type="ORF">G6M90_00g066690</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Laccase; part of the Pks1 gene cluster that mediates the biosynthesis of an anthraquinone derivative pigment that contributes to conidial pigmentation that provides protection from UV radiation, heat and cold stress. The polyketide synthase Pks1 produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though condensation of acetyl-CoA with malonyl-CoA. The dehydratase EthD and the laccase Mlac1 further convert the anthraquinone derivative into the final conidial pigment.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pigment biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539275.1">
        <property type="nucleotide sequence ID" value="XM_014683789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY50"/>
    <dbReference type="GeneID" id="26247933"/>
    <dbReference type="KEGG" id="mbrn:26247933"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028952424" description="Laccase 1" evidence="13">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="66"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="191"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="405"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="565" mass="62481" checksum="9548A3753E8D3829" modified="2021-02-10" version="1">MKLPSFVLFAVAATQTGGSAVLSRAPCTGNTATTRSQWCDFDINTDYYDIVPDTGVIREYFFNLEQVTTAPDGFSRVAYAINGTIPAPTIIADWGDIVVIHVTNNLGIAQNGTSIHFHGIRQNRTNEMDGVVSITQCPTPPGSTITYTWRATQYGSSWYHSHFGFQAWDGAAGGMIINGPATANYDEDKGIVLLSDWNHRTASELYSETLTKGPPGISNAIINGTNIWKDESGTTVGTRFNTSVTAGKSYRLRLVNGGIDTHFKFSIDNHTMTVIAADFVPIVPYETTLLNIGMGQRYDVIVQANQHSVADNFWIRAEPQTACSSQNSNQGNILGILYYGNKPDTPTTKGYAYKVAACEDESLDNLVPHVARSAGKEHWSDLELADLIQQENVFLWALNETSFYVDWANPTLLQVYNDEKEFTHRSHVIQLDEKNQWVYVIIQAQNAASHPIHLHGHDFYILGQGTGTYNSTQQRSLSNPTRRDVALLPGSGYLVLAFVTDNPGAWLMHCHIGWHTNTGLALQFVEQYGAARGLINHDFLNSTCEAWSRYVSRTSIKQGVYEDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYH9</accession>
    <name>A0A7D5UYH9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ASS1</name>
        <name evidence="11" type="ORF">G6M90_00g058970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986826.1">
        <property type="nucleotide sequence ID" value="XM_066130674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYH9"/>
    <dbReference type="GeneID" id="26242883"/>
    <dbReference type="KEGG" id="mbrn:26242883"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="10">
        <location>
            <begin position="236"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="10">
        <location>
            <begin position="354"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="496" mass="54557" checksum="26EA6FECE4C70143" modified="2021-02-10" version="1">MSDNKRVCLAYSGGLDTSVILRYLRLEGYTVVAYLGNVGQDEDWAAVEEKALALGAERMVIEDLQQEFLEELVFRGIQCNAIYEDRYLLGTSLARPVLARALVRTAQKYNCQILSHGCTGKGNEYVLAKTMALANNDDLPGSASLPSLKVSGTHTAPGFLNSIKWSKYTNGMTIYSRSNITIVRFELAWRALDPTMSIIAPWRMPKFFNRFQGRQDLLKFAAENNIPVSSSPKSPWSLDANLAHTSAESGILEKPEVVAPKDVWTKSVDPLDAPDVPTKFSVTFKAGIPVKLDVEGGETYTNSVALFKKLNEIAGANGVGRTDLVESRYFTIPAATISPPPPKTRTCTDNIASFIGLKSRGCYDAPAHTVLRLAHVDLEGMTVDSKVRGIMAWIGNEWSQCLYNGMYFSPERELLENSIIYSQKHVNGTVNMMVYKGAAHVLSRSAPDSNLYSEEQASMDTLEGFSPEDTSGFIAIQAIRLEKYGAAKIQHGEPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYU6</accession>
    <name>A0A7D5UYU6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g072450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545818.1">
        <property type="nucleotide sequence ID" value="XM_014690332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYU6"/>
    <dbReference type="GeneID" id="26241851"/>
    <dbReference type="KEGG" id="mbrn:26241851"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="159"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="52973" checksum="BF2ED65507200943" modified="2021-02-10" version="1">MEPSPTIGTMQTPEDASTSYEYISPIGYSYYANATSLSPKFYQTLLDRCWRRSGKLLYRPDQRRSCCPHYTIRLDSGQFKPSRDQRQTVNRFNRFVLGESYIKDAARLYPKPRKEVKRRDNEFCLVDRIHEAEYGNLQTPPEPAHKLVITLEDDNFTEEKYQVYDNYQRVVHKDLPEDRTPRAFKRFLCSSPLRREVMVTPDGQNRKLGSYHQCYRLDGVLVAIGVLDLLPDCVSSVYFLYHESVHKQTPGKLGAMHEIALAKEEGYRWWYPGFYIHNCPKMKYKIDYSPQFILDPNSFGWDPLDQATLNLLDQKPFLSLSIERQEASTADSGPETDETRGSERPKVSNQDGQTTPRNGTRTEGHDNREEENNDEDEDIGSLFQSSMPGITCASDMEEVDLDHIALKVFSTGPLFETSDLVAWDSKSITDWPGIKASVAELIAAIGPDVKDLICLDMARERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYX0</accession>
    <name>A0A7D5UYX0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g062050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986720.1">
        <property type="nucleotide sequence ID" value="XM_066130736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYX0"/>
    <dbReference type="GeneID" id="90967845"/>
    <dbReference type="KEGG" id="mbrn:90967845"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="81" mass="8876" checksum="B3C5CAAE7D7F3F84" modified="2021-02-10" version="1">MTNGKDVMALRMTHSQQSLYPFCHFNHSRASWDNVAGQEVAAVSTVARLHIAVVCIVSGGKLARANVIVLMVHTEYMNGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ00</accession>
    <name>A0A7D5UZ00_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986844.1">
        <property type="nucleotide sequence ID" value="XM_066130576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ00"/>
    <dbReference type="GeneID" id="26246307"/>
    <dbReference type="KEGG" id="mbrn:26246307"/>
    <dbReference type="OrthoDB" id="5240423at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="219" mass="24097" checksum="D433028DE74BDD79" modified="2021-02-10" version="1">MKDLAPPQPSLRPSNPDAEDGRVAKEIRRCLELVQTCHQDLQHLIDLRNEHLKLLEAAPPRILDRINRVIDSAKIDFRGQEPVIIRHNAAVLAELNYLRQITTCTLLDNIPTTKEDPDIAPLRISQGTNKKASASVPAITVSPMPISRATTPKVIEYCDLPEPVFPNALPGATPDKETLVLAVQPPSAHLPTILGEDPSPHRVVLGPSDDRGLLLLFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ53</accession>
    <name>A0A7D5UZ53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Efflux pump FUS6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FUS6_1</name>
        <name evidence="10" type="ORF">G6M90_00g063910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542494.1">
        <property type="nucleotide sequence ID" value="XM_014687008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ53"/>
    <dbReference type="GeneID" id="26244443"/>
    <dbReference type="KEGG" id="mbrn:26244443"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="561" mass="59847" checksum="39DD0CD30D6EE79B" modified="2021-02-10" version="1">MQAGTASGGSTATSQEARDSDGPTGGSESPTGGPTTPAKSAGAAPALNRDLRFWAILLAIGFSGLLSALEATITSTTLPTVIAELGGGDLYIWAVNGYFLAMTSLQPMFGQLVNVFGRRWPTICATAAFVLGSGICGGATGMGTLIAGRVVQGIGAGGINVLVEIIICDLVPLRERGTYFAIIFGLVAIGTALGPFFGGLIVTYPSWRWVFYLHLPVGGFALLLLLVFLNVKHNREKTLATRLTTIDWVGNVIFVLTPLIVGFSGLVGFVIFEASALAPYPTVPLHLLSNRTSAIVFFLTLMHSIVTMWAIYFLPIYFQGVLGSTPSRSGVQLLPTILILIPFAAAGGALMSKLGRYRAIHQAGHALMVLGFGLFTLLDENSNTGTWVGLQIVESAGAGLIAPTLLPAVMAPLAESDTALAAATWAFFRSFGLTWGTAIPAAIFNNRFDQLAETEITDPVLRSRLTGGRAYESATAAFRSTLSEATRNEFTRVLEMSLQRTWQVAIGFAALGFLLVFLEKEVPLRQELETEFGMVDKKDREENVEEAKEVKDPDPQKQNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZQ9</accession>
    <name>A0A7D5UZQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">rrp5</name>
        <name evidence="16" type="ORF">G6M90_00g056590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544250.1">
        <property type="nucleotide sequence ID" value="XM_014688764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26242662"/>
    <dbReference type="KEGG" id="mbrn:26242662"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05706">
        <property type="entry name" value="S1_Rrp5_repeat_sc10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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    </dbReference>
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        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAT"/>
    </dbReference>
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        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="147"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="450"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="542"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="636"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="724"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="820"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="915"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1023"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1110"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1204"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="15">
        <location>
            <begin position="1293"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1368"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1368"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1386"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1413"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1489"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI69492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1791" mass="198063" checksum="00796EA3886EEE93" modified="2021-02-10" version="1">MSNLKRKDAPGGQPPAKSAKNTKQGRPSKTDAPEIAKSKTAKTQPKKTSDNDAHPKAPVVSLLKNEEPIFPRGGGSVLTPLEHKQIQLEAKADARREEEFDTRGGKAQKIPKKRKVSLKGGKRSAENKDSEDFVKVESLNFKKLVKGSLVLGQITRRNNLDLEVALPNNLTGHVSVVAVSEQLTNRVQEAAAEQDDEEDESSDETDVDLKSMFVVGQYLRVYVVSTMDESAIGNGKNKRRIELSLRPTETNSGLGKDDIVANSTVMASVVSVEDRGCVMDVGIPDLRAFLPHGEIDATIDQSRLQEGSVFLCQVTGKVSNGNVAQLSLQQKKLGSPKGVPTEATTINTFLPGTNVDVLITNTDRRGLAGKVIGHLDVTADLVHSGAGPLGTDLEATYKVGSKVKARVICNFPTAKEPKFGISLLPHITSLTSKHPAKDNKNLPTEVLPISSLVEKCTVRRVESEIGLFVDTGIAGLGGFVHISRVKDGKVDALYESSGPYQVGSVHKGRVVGYSELDGQFHLSFEKSILDQQYIRMEDVPIGAVITCGIEKLVIKEEGVRGLILNIADGITGYVAERHLSDIKLQHPEKKFREGMKVKARVLSTNPFTKQIRFTLKKTLVNSDAPVIKSHEDAIVGLQVPGTIIKLQPNGAHIQFYGRLKGFLPVSEMSEAYIRDPNEHFRIGQVVSVHILHVDPEQRRLIVSCKDPGAFGLDKQTALKNLRLGELVAAKVTQKTEDQVFVELVDSQLKAILPVGHLTDKSASKNQFALKRISAGQTLSDLMVLDKNEKRRAIILTQKPSLIKASKEGKLISNFEDAKQGAIVPAFVRNVTQTAVFVQFAGNLYALLPKSRLPADVQSKPDFGMHKYESIEVKIVSVINDLRRIMVAHATAAPIEEVTEKQKDKVSAPADGLEFGTVVTAVVTSVKETQLNVQLTDTQVQGRVDVSQVFDKWEDITDPKKPLDKFHRKQQIKVKVIGVHDAKDHRFLPISHRSAHSVLELSAKNSDVEGENPNTLSLESLKVGDSHIAYVNNVTPQFLWVNLSPSVRGRVSAMEASDDLSLLNDLEANFPVGSALKVRVKFIDAEKNRLDLSARSSTDSQGVDWTSLKQNMVLPGKITKVNERQLMVKLSDIVSGPVHLPDMADDYDDINTLNYKKNQIIRVAIVEVDASNKRLRLSMRPSRILSSTLPVADKEIANLSQVAAGDVVRGFVKNVSDKGLFVALGGHVTALVKIANLSDRFLKDWKDLFQVDQLVKGRVLSVDSALKQVEMSLKASAVDEDYTPLVTYNDIKKGSVVTGKVRKVEEFGAFILVDKSSNVSGLCHRSQMADEAVKDATKLYKEGDAVKALVLEVDAVKRRISFGLRPSLFDEDTDMESNDSDAGGVALEDDEESDDEEMSEEQKALLEKLLSNDSGDDDDNDDEEEEENDDGEDDEDEEMEDAPITKSGGLGLGKKSAWSADPFDESGSDSDDQAQEKKDSDKKTKKRRKGEIEVDRTAELDAHGPQTSSDYERLLLGQPDSSKLWIQYMEFQMKVSELAKAREVAERAIKSINIRKEEEKLKVWVAYLKLEVTYGTKQTVEDVFKRACQYNDEQKVHEELASIYIQSQKLKHADDLYESMLKKFGAKAPSVWTNYATFLSVTRNQPDRARALLPRATQRLPAHQSQNIVGQFAALEFRSPNGEPERGRTMFEGLLATWPKRGDLWSWLLDLEEGVAGGDPTAVRDVYERRTRVKGLKPNQAKKWFHRWVKWEEKLDPKGKEKVMAKAQDWAALYKARKEAEAAEKEDEDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZV0</accession>
    <name>A0A7D5UZV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539382.1">
        <property type="nucleotide sequence ID" value="XM_014683896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZV0"/>
    <dbReference type="GeneID" id="26247826"/>
    <dbReference type="KEGG" id="mbrn:26247826"/>
    <dbReference type="OrthoDB" id="10342468at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028919138" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="101" mass="10952" checksum="82E92EF2D133EC04" modified="2021-02-10" version="1">MQYPLVLVAAFAAACIATPTAAPASVQSKDEMPTGLCPKDQLVIVDGLGYYLPQAECLVLKERCGQRNTTKPAELKKCITNTRISEIKEAQKAVQDTKRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V038</accession>
    <name>A0A7D5V038_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g067230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539267.1">
        <property type="nucleotide sequence ID" value="XM_014683781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V038"/>
    <dbReference type="GeneID" id="26247941"/>
    <dbReference type="KEGG" id="mbrn:26247941"/>
    <dbReference type="OrthoDB" id="3783227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="350" mass="39547" checksum="9FB1ECA5A6F7E0C4" modified="2021-02-10" version="1">MTDLFFSRACSPSSAGNLAIKSDSGVDSDLVGGLRSGRGASGSRLSDNEKLLLHNFLLHCKLPGRKADRLYLEDATALVSVSNRVVDTLQRAFNKYYVDKEPPESIYIVFIRIPARKVPSAAFHSAQKLAEKCGMSDADKFKHEFLFEWAIPDDFVVHSVSIKTLLDRGLTLKKFLIKDQRLPPTAELCHKMRHDIFRTDSDAWEIGLALGFFVRPFGARAPSCWIASQLFWDLIQGLSWETLKGLGIPQSVKIDSRGGELGHAALSFFEQITDGIETCLDWWLLDDRFVLAFEEYKLWRDLKEERILDACNYLYLIIPSRGFELAEASFEREQTRFMAEVEAAAIKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0N6</accession>
    <name>A0A7D5V0N6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g071020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545955.1">
        <property type="nucleotide sequence ID" value="XM_014690469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0N6"/>
    <dbReference type="GeneID" id="26241988"/>
    <dbReference type="KEGG" id="mbrn:26241988"/>
    <dbReference type="OrthoDB" id="4941527at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028829579" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="141" mass="14117" checksum="6936C210B0F2B9E9" modified="2021-02-10" version="1">MKFTFATILLPYLLHGALAAPYNVERDLNGEQHDLADRDFDIRNALPLEENSENTGGVANNNANANGEAATQVAAVSATQTAGAGAAQSSAAAKDGAAKKKGKGKGKAKGKAKGKGKGKAKGKGKAQANGQGNEAAAKGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V124</accession>
    <name>A0A7D5V124_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SAT4_8</name>
        <name evidence="11" type="ORF">G6M90_00g089220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541586.1">
        <property type="nucleotide sequence ID" value="XM_014686100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V124"/>
    <dbReference type="GeneID" id="26245449"/>
    <dbReference type="KEGG" id="mbrn:26245449"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF191">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="422"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="334"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="783" mass="85489" checksum="9177420311E459E9" modified="2021-02-10" version="1">MALSLGQVHPWTTSNTLGPAEDQPMSSSAKETGEARASLPAHPKRPAPSPPSSVSAKQSEAPTPTPTATDSSTTTSATSDSLSVPYYSSSYSSSPRQFPSDITDPILEEGDVGSGTDSPIEPVTPVSGGRLSQDFTTLRQSHYSHYSDYQALQRAQTAQNPPTSAPKKAPLLISQSSAPPAALVSSDPSSTPRAAESETSPQAPLQQRTTRGSTKSLKRTMSRLFKRSNSSLEKEREFVIVDTPAPISESAPQSTSYLNGNDAPSSRYLNGNKSSTTTQSISPPSPGSPLEMAPSHRSAIDTNGTLPNAVDFQKKNRATTGLTLRGRAVNFVGATMGRGNRPTKGPRRASSFDMSNRPPVPALPKPIDEEKTYPPERLPWPLPPDAGTGAKARRMSLSLPDDFTVDVAELLSEFEYQHKLLGRHGKHLGKGAASKVTLMVRKGCPGELYAVKEFRGKSNRESQGDYEKKIKSEFSIGKSLHHPNIVETVRLCTDHGRWNHVMEYCAEGDLFGLVQKGFFKGEDKKKDRLCLFKQLIQGVNYLHANGIAHRDIKLENLLLTKDSKLKITDFGVSEVFSGTHPGLREAGGQCGQNMGEVRLCSPGICGSEPYIAPEVLEKKHSYDPRALDVWGSAIVMIYLTFGGAIWSRAQLGNLHYDKLVKGWNRWYEKHPECDACITDTDYPNCYALDVGVNPPALRRILLQMLNPDPAKRIPINEVVNNRWMKNVECCQLESYDDPDQFIDATKKDYSSKISTKKIFCHNHLPPKTSGSHSLGKMPGTAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V156</accession>
    <name>A0A7D5V156_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">VTS1</name>
        <name evidence="15" type="ORF">G6M90_00g088470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542267.1">
        <property type="nucleotide sequence ID" value="XM_014686781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V156"/>
    <dbReference type="GeneID" id="26244781"/>
    <dbReference type="KEGG" id="mbrn:26244781"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="545"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="257"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI71935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="612" mass="65284" checksum="013F9B9E8B9A96E3" modified="2021-02-10" version="1">MSGNNIIGNRNSTPEANSTSTLRPPSARAIGSGSSLRASADMTVLTGSSSVSRIRPSSDFYGQAQQGHGQGNAENDSQDKIAQQWIADIDQYETTLEEMAAATLDQDFKDELSAIEQWFRVLSEAERTAALYALLQQTTQVQIRFFIQVLQQMGKNHPMSGVLSPANFDKDPMSNRLSDAMNKLNVDSARNSFSRNSTIASAKRNSGLDPSTINAMFPDAAAAIATEKAKFTQQTGNPPSSNRNSAAIDTRVSISGGQEARDASALNPASPWGAGAVNEPSTAKGNTSQVPMGQFVQPPPSGGLRSPRPQMAGGSTIQSTTLNAPEKNPSDLPLLSPYQSGSGNWASMVNTPMAPTFNAATTGGKQADMMANATVMKLAALSTVNNRIALDDVRKYRRARSNDAPGSAHAQVSPSSQAVNLPGTNVVMINEHGQVLSPEQVLAMQAQQSIGLGGQRSRPSSPGLAMHQTLGPVPHFTSPQHNGFLSAYDGSSGLLGTGIPAVSLGQLGMTGHEGYLSDHSDIVRGRSPRGRRGSSKAPEDPADPTLLQDIPSWLRSLRLHKYTENLRDMKWTELIELDDKALEERGVNALGARRKMLKVFEQVKEAKAEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1I2</accession>
    <name>A0A7D5V1I2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">chs-1</name>
        <name evidence="16" type="ORF">G6M90_00g076160</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545485.1">
        <property type="nucleotide sequence ID" value="XM_014689999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1I2"/>
    <dbReference type="GeneID" id="26241518"/>
    <dbReference type="KEGG" id="mbrn:26241518"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="666"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="885"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="15">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI71199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="920" mass="103105" checksum="9C122CAC1A46156F" modified="2021-02-10" version="1">MAYNGHGQGQGQGQGHEYGGHPMQDLPSGNNYHITPQDHDEDARGYLLNEPPAHGYDHDRLGVGTPPDRPVSAYSLTESYAPNASQLPPAGSGGFGDNGFGQYGQPQGFGGPYDRPLSAVHDEEESWMQRQQQPGGAGQSGGLKRYNTRKVKLVQGSVLSIDYPVPSAIKNAVQPRYRDVEGGNEEFMKMRYTAATCDPNDFTLKNGYDLRPRMYNRHTELLIAITYYNEDKVLLSRTLHGVMQNIRDIVNLKKSTFWNKGGPAWQKIVVCLVFDGIEKADKNTLDVLATVGVYQDGVIKKDVDGKETVAHIFEYTSQLSVTPSQQLIRPTGDSPQNLPPVQFIFCLKQKNSKKINSHRWLFNAFGRILNPEVTILIDAGTKPSPRSLLALWEGFYNDKDLGGACGEIHAMLGKGGKKLFNPLVAVQNFEYKISNILDKPLESSFGYVSVLPGAFSAYRFRAIMGRPLEQYFHGDHTLSKILGKKGIDGMNIFKKNMFLAEDRILCFELVAKAGQKWHLTYIKAAKGETDVPEGAAEFISQRRRWLNGSFAASLYSLMHFGRLYKSGHNIIRMFFLHIQVIYNILNVIFSWFSLASYYLTTTVIMDLVGTPVVASTSGSEHHGWPFGDSATPIINALLKYLYLAFVILQFILALGNRPKGSKFTYIASFMVFGLIQGYILVLSGYLVARAFQQPITEQIKLDSSEDFVRSFFSGSSAAGVILIALITIYGLYFLASFLYLDPWHMFHSFPYYMLLMSTYINILMVYAFNNWHDVSWGTKGSDKAEALPSANVTKSEKNEVVVEEIEKEQEDIDSQFEQTVRRALAPFKEVEEIEKKDVEDSYKSFRTGLVVSWLFSNILLVVVITSDNFNSFGIGKSASVRTANFFKFLLYATAALSIVRFIGFLWFLGKTGLMCCFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1J9</accession>
    <name>A0A7D5V1J9_9HYPO</name>
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        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72255.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="414" mass="45951" checksum="075EDFD346D8107D" modified="2021-02-10" version="1">MWSDNQAVDDATYTLQIVAEIDRLRSQINDEAACQYASRLNGGRSCSIEHSSKVGPGALMGNANYHARIRFHDGSPSWLLRVPRVASFAVGLPVSLADYLILSEYATLKFLETTTVPAPQAFGYGVCGNGTDHGVGVSFLLMQELPGRPWTGEGASGKAATEDEKARIWGDLAEIMVELEHHPFPKAGSLCFQLSNIEVSAVASDRFVVLTPHGPFHNSTAYYTAFAEQYLQLIADGQLYTEYPVDAYLVYRFLKDKASHLAQQGQAQSREEFFLKHVDDKGDHLLVDDDLHITGIIDWQMARVVPRREAFGPSLVTADMSALCRGKVSLSSDDVALTDALRQRGISTCVTDEKVRRFFWGLALEPKWSRALPLASAILEVFGAGQDWTRWRETALKQYETDGRLKGLVERYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1L4</accession>
    <name>A0A7D5V1L4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1L4"/>
    <dbReference type="GeneID" id="90967922"/>
    <dbReference type="KEGG" id="mbrn:90967922"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="100" mass="11352" checksum="310707C2D6700B0D" modified="2021-02-10" version="1">MSKYDDEQWTNDAAYSLSLTNKSISRLAVLNWNHRRPRRIAFNLSQDDVGPVVSSSVLVSLFRPHYLTFNTGKKLTLYAMSNVPQEAVRYSLVTLCGTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2A3</accession>
    <name>A0A7D5V2A3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g105580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987595.1">
        <property type="nucleotide sequence ID" value="XM_066131677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2A3"/>
    <dbReference type="GeneID" id="90968206"/>
    <dbReference type="KEGG" id="mbrn:90968206"/>
    <dbReference type="OrthoDB" id="5148067at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="112" mass="12367" checksum="CC13462E8140621F" modified="2021-02-10" version="1">MLSSGLRIQDSSHRGDLAVELHLSVLKRYGTWRHCGHGVEIRPVGIMCKQDTFAKNSTPYVWDTTMGGKRVLVGEFRARARFGNSCVLVMDTKEVDNVVTSGSCVAALNRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2F9</accession>
    <name>A0A7D5V2F9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g075130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545583.1">
        <property type="nucleotide sequence ID" value="XM_014690097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2F9"/>
    <dbReference type="GeneID" id="26241616"/>
    <dbReference type="KEGG" id="mbrn:26241616"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="72" mass="8120" checksum="564B4C901559FD6E" modified="2021-02-10" version="1">MAGKKIRCSTKDCREPVQRIFGDCGFCGGHFCGKHRLLEDHKCSGLEDCKKQSHERNAAQLESERTQVIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2P0</accession>
    <name>A0A7D5V2P0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COA3</name>
        <name evidence="11" type="ORF">G6M90_00g102560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987545.1">
        <property type="nucleotide sequence ID" value="XM_066131601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2P0"/>
    <dbReference type="GeneID" id="90968183"/>
    <dbReference type="KEGG" id="mbrn:90968183"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI72797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8318" checksum="97E1DE29AC8B15FA" modified="2021-02-10" version="1">MAGSSGHSTYYDRRYRQGPALIRARRPYLFKNAFTGLGLLAVVGGIYWYTLKAVGQDDFDDVKVPDAPQNPVPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V331</accession>
    <name>A0A7D5V331_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Striatin-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Strip1</name>
        <name evidence="5" type="ORF">G6M90_00g097110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546629.1">
        <property type="nucleotide sequence ID" value="XM_014691143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V331"/>
    <dbReference type="GeneID" id="26241052"/>
    <dbReference type="KEGG" id="mbrn:26241052"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="3">
        <location>
            <begin position="108"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="4">
        <location>
            <begin position="509"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116647" checksum="14825E5E653A0C50" modified="2021-02-10" version="1">MWPTPRSVPEETSEPPRPTDDVADTGEVAEGGMRAEQLNKPPVPVPPSRPGLQRNAMPSGFAAAAAAAGPGQAKLKQQPQQPQGPAPTDSLSLLQLRRIVAEVNRAEPVAYDFVYSDMGPHAEEIDEWFVYQFWQWVRLNAAQKAFEWHWNNDSDGQHSWDDADHDTRAKFIQAAIAGVQSNDAALRSASIGKIVYLVLGRWGDTAMPNAPVGGSRSIASIPQLQAIKAGVECLASLEGLPVIWEALRNCFELHWSGDIHQQASPQEAQDELMNLMTIMYIAIQETLNDPDDMSSSYKALLELNPSLVDFMLTATSKLRWDEQNFMPLTQIFLLFWKTILLVFGGTRDLAKVKEALSEIREGMNKETITASPLDYHVFRQEITSKYPAYVPPQPLIPLEDETTSILPPIPNHPARNNGSNGIIATPAQLQAGGASILNQPVHIATPAPSPPPSPGVGGKAGKKQNYQTNQNFPFMYPPLDATSNSAGGKGMAGIDNSIVSRRWEGSDIPASILEAGELFSTRVRMTRATRQMWEERERFLKFERGWTENDEDEDEIEDLDLNELTLEEREVLKEIKAEEKTTRHVHVPEPEVDYGPHPENLSERDKQRLIAVERFYKESLPHLQSLVIVLLRPILVNVTAIVAQQASQMPNGMAGRGNNPGMNGGPVGPRPPEIPGQIAAQEEPEPSLEEVDAARTREITSKAMTGILVLLLKWLRISHVLKFEYFTQLLLDSNYVPLVLKLFAHQDVQQVVDSKMDRVENSFFQFCNLRSKLKDKADSDLEIEDEEEREDAEGENKTGQQMQPDSEDDSEDDAVPPPIKRRRSPARDLDPEEEDEGEASDDQASTRPEVDELGYPVNPLPEEPITDFSRRNFFSLINYLRVLQKICKNKSHRNLLLVQYKSSTILRKSLRVPQPELRLYTLKLFKNQVPYCGRKWRQSNMRVITAVYLHCRPELRDEWLAGSDVDAEVDSALPLEQALRSLTHWLNVRRYPDKIAADIRTAMREEQDFFTRELEKIDVGWGDEAEAGGELDHVEGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3M4</accession>
    <name>A0A7D5V3M4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g105290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987701.1">
        <property type="nucleotide sequence ID" value="XM_066131672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3M4"/>
    <dbReference type="GeneID" id="90968205"/>
    <dbReference type="KEGG" id="mbrn:90968205"/>
    <dbReference type="OrthoDB" id="4741757at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20687" checksum="D8A5F84F9B4876AA" modified="2021-02-10" version="1">MPPFNGDSNYGSTPLAMLDEGIRMAIRNPLQRLHKQELPTWYPDIEAALIKLIQLGTKISQYSQAFDPRRKLIALADTISPFSSIYSVINTQLILNTRQSITSRVDRGNLSLVLALVDGWLRSCEEYIRKEPSVRVYSDSLAFEDTHKELITAATQHTAYRLHVPDDLLRLFDSLGLIKGLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3M9</accession>
    <name>A0A7D5V3M9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein RDR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RDR1_3</name>
        <name evidence="9" type="ORF">G6M90_00g113310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539772.1">
        <property type="nucleotide sequence ID" value="XM_014684286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3M9"/>
    <dbReference type="GeneID" id="26247437"/>
    <dbReference type="KEGG" id="mbrn:26247437"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="566" mass="62857" checksum="1236B538D41B71FB" modified="2021-02-10" version="1">MTPSTTGRKRSRLACQTCRDLKRRCDGARPCGTCVRFEYECIYHEGKTRKGRRPQSLEHTAPAIKPPTPAAVRLMNAQASPEEAAQSTSGAPPHNQARSLEANSGSAFVRKLALRLDPKKNPRMHTFAWNAFLGSRQAKRIPVYHAITELLSLQRMQELATVYFQQVDPIYGFIDRHEVTRHIQLRWTAQMVQQASDAVLCGIAALGCLFSRVHSDQAELDLVESARILLEQSMSTPATVTSITAWLLRVVYLRVAGTHYEAWMASSMVMHMIEAAGLTVESSSESALPSTRQEVDSETARRIVLVAQHLNIWMSFDMGLTRVSLSNISIAMLPTPRPGDYTYEISELLPFSIELDPERKPTAAELETALHTVLSRAHSIPPTVLAQCNLALCLCRRLRSLEVSLTESILQKILVLTTNGIQAAQAILAARAPWHHMAYVPFQIVCVLLAIDTVSSISQLRDAMQCLKDISAVYNTKATEDALKTARSLVLLHQRGKEMFASALSDILKLCPANPVDVVSETSPTLSDGTEWMDGFPMDFSNLQYFDIEQFLNPGFFWNAGSNGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3S9</accession>
    <name>A0A7D5V3S9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall galactomannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g107000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544136.1">
        <property type="nucleotide sequence ID" value="XM_014688650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3S9"/>
    <dbReference type="GeneID" id="26243523"/>
    <dbReference type="KEGG" id="mbrn:26243523"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028910264" description="Cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19200" checksum="BACB27B914F8CB91" modified="2021-02-10" version="1">MRFATPVTLLAAISGTCAMVIQRDNPLAKCINSVTSSLNKLDVATKSFNGDIQPVVEAADNVIATIQHGQMVTDGTPSIGLFSAAALLQPVQILDNRAKVLFVDVKGRVLDVQKAKKCDVTRAKLSTLNFVGHKLIDTILNKISSGFARNIARPFTDDIKGLLAKSLDLFEGARCVDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3W5</accession>
    <name>A0A7D5V3W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g100700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546279.1">
        <property type="nucleotide sequence ID" value="XM_014690793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3W5"/>
    <dbReference type="GeneID" id="26240702"/>
    <dbReference type="KEGG" id="mbrn:26240702"/>
    <dbReference type="OrthoDB" id="4935313at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="283" mass="32254" checksum="1565204728EEF01A" modified="2021-02-10" version="1">MTPRHFSQFEQAQKSYQTRAKDYDSSWHPQYTARFMELIDIQPGDRVLVLACGTGLEAVIACPLVGDNGLVTALDASAAMMDVCRKKQATDEILSRRLVLIQHDVTDLESCEHLEKGSYDVIICSNAFVLFDDPGRVVSQWAGYLRRGGRLIVDIPHENHPRQGLFMKKAIQQMGMTYPASRSWIESVDSFRGILEARQLHVFRVEALDKEPGKGHVFLGREEIGSMFDYITQDHLMQCLADEQFRSKARLLFEREWDSATEREGNGKVKVSYVLYVYVAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4B5</accession>
    <name>A0A7D5V4B5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hem14</name>
        <name evidence="13" type="ORF">G6M90_00g109110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543943.2">
        <property type="nucleotide sequence ID" value="XM_014688457.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4B5"/>
    <dbReference type="GeneID" id="26243330"/>
    <dbReference type="KEGG" id="mbrn:26243330"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI74535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="554" mass="61585" checksum="272B712E0189E2F9" modified="2021-02-10" version="1">MTNRRSYATQSNNGDIAVVGGGLTGLTTAYYLAKQLPSTAKITLYEGSDRLGGWIRTDRVPVDVEGVGGVVSFERGPRTLSSNHLSTWKFDDLVLYDLALDLGLKVFTPPDQPRYIYYPDHLVTLPPAGSFAEFCREPLFLQSIWGGLGFLLRRMRSRAVPIKDMSVSEWLYEISGSRAVAENVASAMIHGIYGGDIDKLSARSVFDRFYWAYYLPNMGSDLRQMTMREQMFMSELSQDPQIRRMALKARGALLHFGRAGMDSLPKALADVLEATPNVEIKKGIPVRDISYDMETEKVNITTGNWADEERQHLENKTTTSHDRVISTMASQDLSRVTASKLPSLAETQSVSIMTVNLWYPKKHMKPRGFGYLIPRSVSREHNTERALGVFYDSDVSGAASPDEPEGTKLFVLMGGHYYDSGAPPPSESDAIEQAKSLLERHLGIPADTPCFALSRFAKECIPQHFVGHNDRMMQADQQLRDEFHGKLAVAGGSYSKIGAMGAIRAGYDIAKQTVGEGGWYTTGLESLEFPEPFVGVPISKIPVRRFRQLEQNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V512</accession>
    <name>A0A7D5V512_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">dsc1</name>
        <name evidence="24" type="ORF">G6M90_00g107860</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544057.1">
        <property type="nucleotide sequence ID" value="XM_014688571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V512"/>
    <dbReference type="GeneID" id="26243444"/>
    <dbReference type="KEGG" id="mbrn:26243444"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028974322" description="DSC E3 ubiquitin ligase complex subunit A" evidence="22">
        <location>
            <begin position="29"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="616"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="762"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QLI74678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="826" mass="91852" checksum="FF546D9FF27CA07B" modified="2021-02-10" version="1">MPSPAQSPAGAVLFILFLVWMLFPEGDYRSQSLALSDLAVDRLARYRDALHVLNTTRWGDFAPQNKTTDDGREAKHLNLTGFRETDGFAWDDLETFRQKGLKLSRHAVPPVDGHQLWDVAQGEAMWTNASGTVHGDWVRKPGSAFRGYDSYNLSRSVPEVEWMAHKVEWARNVTGNAGRMMLRLSGNKTLTHYEQLSMDMAPLSGGIIRSLRGTATIEDTIGSGLNWEMKLWGVHWPRQGVILMTTTSEKFEGIFALPHLSPGPDFFQSSQMLLNQTLARVIRRKEKHVYVDQRMPWNSDIENPMYTAYPSPHCEYIMYAQVHPPIPPKPTEGQDAAPGAVGDTINAIESELQYPVGAPIPRIPKLKMSAVVYSPDCSFFLETKGPPDYPLSEADHLVGMKKEVQTHQIKTWLLLYALVVFGQVRLLRDQMKESFTPSTMGRISFGTISAMLIVDGMTFTAAATWVSSAAATFLPTLALMFASFLSMTIGGSFLAKIYEVQLPESRGRRDQSSSSTTTAQDSSANSIAATPTPGLLPGPVTASQRVETPIIIPSDQDISAEIAAAASAIPTANRSSPSTPETPTFQAIIGRFILFSLCVSFLAISSSTWYPRPRSVFLNTCAFIYLSMWTPQIYRNTLRNCRRALAWPFVLGQSVLRLLPIAYFWVKEDNFLYATTDVPAFVFLAGWVWIQVVVLAAQQIVGPRFGVPLSWTPDAWDYHPVLREDNLEGGGLPIGLVVPEERNSLDRALAGAEKTGVRHIDCAICREVLEVPVVKAGEEESSVSGVFARRMYMVTPCRHIFHTACLESWLRFRLQCPICRDELPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5W4</accession>
    <name>A0A7D5V5W4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540324.1">
        <property type="nucleotide sequence ID" value="XM_014684838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5W4"/>
    <dbReference type="GeneID" id="26246918"/>
    <dbReference type="KEGG" id="mbrn:26246918"/>
    <dbReference type="OrthoDB" id="4933075at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028847244" evidence="1">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="201" mass="21514" checksum="A30FE4F2D21F754E" modified="2021-02-10" version="1">MAWPQAIQLAVLGLLHSVHARPAGFAPGLFPYIFEGQCYNISAGDEASSPTTIGFYTSGTRIKINDAEYDTPRVLGDYSCKFSELSVDGYATHIERSIALYITTEAGEGVRPSLPLRKAQPLVLQAGTGGDATFGCAGGQEAFRGSSADAWGQVRNKWLYVIDGELLNTEKDKCCRKGSNPFTNAGSGRGYKSGPVCDPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKR7</accession>
    <name>A0A7D5YKR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985669.1">
        <property type="nucleotide sequence ID" value="XM_066129615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKR7"/>
    <dbReference type="GeneID" id="90967430"/>
    <dbReference type="KEGG" id="mbrn:90967430"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="62" mass="6548" checksum="57A363AC140D9ACE" modified="2021-02-10" version="1">MAILTGLAVKADDTENNSRAALGIAVETRRANRTAASVKSGSSNGSTRKESGDSEELHVEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLU7</accession>
    <name>A0A7D5YLU7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.12</ecNumber>
            <ecNumber evidence="10">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">G6M90_00g026960</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="13"/>
    <dbReference type="EC" id="1.1.1.9" evidence="10"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985864.1">
        <property type="nucleotide sequence ID" value="XM_066129979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLU7"/>
    <dbReference type="GeneID" id="26237334"/>
    <dbReference type="KEGG" id="mbrn:26237334"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="17">
        <location>
            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI64960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="366" mass="38677" checksum="4C033666AB1A4E5C" modified="2021-02-10" version="1">MATQALNRDEISNLSFILDKPYQVSYAERPKPTLSSPHDVIVAVNYTGICGSDVHYWSHGAIGHFVVKDPMVLGHESAGTVVEAGSQVTHLAPGDRVAIEPGSACRRCPDCRAGRYNLCDAMVFAATPPHHGTLTGLWASPADMCYKLPAAVSLREGALVEPLAVAVHMVRQAAVQPGQAVVVMGAGPVGLLCAAVARAYGASKVVSVDIVPSKLDFARRFASTHTFLSRGGAPEDNARDIRELAGIPRGADAVIDASGAEPSIQTGLHAVRVGGTYVQGGMGKPDVNFPIMAMCLKEVTARGSFRYGPGDYELAVELVASGKVDVKQLVSEVVPFDRAEEAFKKVKEGEVIKILIAGPNEKIDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN14</accession>
    <name>A0A7D5YN14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">THIO_1</name>
        <name evidence="5" type="ORF">G6M90_00g026800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547906.1">
        <property type="nucleotide sequence ID" value="XM_014692420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN14"/>
    <dbReference type="GeneID" id="26237350"/>
    <dbReference type="KEGG" id="mbrn:26237350"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="165" mass="18011" checksum="7211F0F39E1EB447" modified="2021-02-10" version="1">METVSYIIWALVIIVILGPALFRDRSPIPETSGNVSKISELPELESLLSSTTYVVVDFYADWCPPCRAIAPQFSKLADEYASKGQLAFAKVNVDHCKGAAKHHNVTAMPTFLFFKNGQQTSVVVQSSKHGTSAKMPKDGVVEKIQGADVMLLRSTVQALAENAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQQ7</accession>
    <name>A0A7D5YQQ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g002140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542867.1">
        <property type="nucleotide sequence ID" value="XM_014687381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQQ7"/>
    <dbReference type="GeneID" id="26244240"/>
    <dbReference type="KEGG" id="mbrn:26244240"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="362" mass="40865" checksum="6DCFBBB7F9EC4962" modified="2021-02-10" version="1">MAHIVPNLLLTRFRQMPFPPQNRETPEPRPSDKTDADDGTYHPTPIDIVVVRIMLIRSVKLPPDLVDAIFDYAEYWAHSTNAIDYRAEHQELLRISGACKNEDQFLLRSYPVGLTGIDGQDTLSEELAYDTQEATPLPRGTDCDAKYFAKLAKYPTPRLLNPARKVVFKIKSHDQGWASGNEEKGTYKGSWTWFEAGLEKFDAAQTSDAQSTRDAPQETRESDSSALPVRALRAVYPKIEQLPKSDDDENKEKEDENESEAEAKYKYVHHLEAQPEWEIHRNLRAVGALQEHVVTWSYLDDIKAESDAGKVLDDQGRGRATGDGSFVRSLVLGDVITVWGKARFPGWVNCGDSVKVEVYWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR83</accession>
    <name>A0A7D5YR83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Potassium transport protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trk1</name>
        <name evidence="12" type="ORF">G6M90_00g045050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986149.1">
        <property type="nucleotide sequence ID" value="XM_066130363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR83"/>
    <dbReference type="GeneID" id="26242006"/>
    <dbReference type="KEGG" id="mbrn:26242006"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="440"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI66422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="672" mass="74871" checksum="9132FDC328E7B35A" modified="2021-02-10" version="1">MGLLSIPFLYLYGNISAIDAYFMGSSASTESGLNVANLNELKLYQQLYLYFATVFTQMGFVNILVVVVRLYWFNKHLNSFGPALLHARRRGGTDSQEDSRLEYGEPKASPPDTSGVAETRASGKGSEKDGVQLAADNNDAIRGPYQDLESEARVSCSSFVEEAIDASAPHISFDSSADKLRHPRSDSVLYVPGPRDRDLGHPLVELTGPRLKSKEELTRYGEDDNGQHRLQTLGPLRESRSIDRAAALASSLFVIGSEPTPSSISRELTRRRRASDDMPYLSTGASIGRNSRFYNLTRQDRNELGGIEYRSLKLLLKVVVAYYFGVHLIGAIGLVGWILHADSKYVAHLDEFAQDKIWWAFYTSQTAICNLGFTLTPDSMVFFQDSPWVMFWLSLLTFAGNTLYPVFLRSILWTMSKITPRGSSIQEPLQFLLTHPRRCYALLFPGGTTWALFGIIIGLNFLGTLILLVLDLHNPEFTHLTPGQRVAAAFFQSAAARHTGAASFTLSNLSPGAQFTLLVMMYISAFPIAMSIRSSNIYEEKSLGYYAQDPTYNEDRGASYLFQHMQKQLGFDLWYIFLGLFYLSVSEATKLADPNQPAFSFFAIFFEVVSAYGGVGLTLGYPDITSALSTKFTTFGKVVMCAMMLRGRHRGMPYGLDRAIMLPDERLVERSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSI5</accession>
    <name>A0A7D5YSI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endoplasmic reticulum chaperone BiP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GRP78</name>
        <name evidence="3" type="ORF">G6M90_00g060680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544637.1">
        <property type="nucleotide sequence ID" value="XM_014689151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSI5"/>
    <dbReference type="GeneID" id="26243049"/>
    <dbReference type="KEGG" id="mbrn:26243049"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="547" mass="60499" checksum="829AD496E9060290" modified="2021-02-10" version="1">MEKRRIIVSIDFGTTYSGVSWAETSRPDVQHVVSSWPAIDGLRSSLKVPTELRKLATGWQWGFQIPEDAKRYRFFKLKLDEPDRPSRDGDTPLELARIYLSCLHDHFIGILEKKLSRAVVQMTPMDFVVTVPAIWSNTAKQATERAAAMAGFCGNKRILLISEPEAAALYTIKHLGPSVLKPGKNFVLCDAGGGTVDLISYEVSHSGNLAVKEITEGTGGKCGSAMLNKRFRRYLKQTHGDKYWTNERLILAIAEFESFKKDFSPKGEPLTIRVDESLGLKRNRFTISQTDMTTRIFTPIMKDIICLIKEQIGLVADEIAAVVLVGGFGESSYLKSEVKAALARNTPVLQPDNGWIAVVKGAVIHGLGYYHPSLTQVQIVSRIARRSYGTCLLAAYDMLRHDPKEAVWSPKEGEMVVAEMCWFIRKGESYTEGIPTAIDYQCDIPVSSGPVPQTEIEIFCNDDPEPPIHCTSRTTCIATLALNLDKIPVSTKNAAGVTRIGNHRYFCLTGAIEASYGSAMITYKVKLGGVTHDALTVRYENQGLGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU61</accession>
    <name>A0A7D5YU61_9HYPO</name>
    <protein>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g015200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549005.1">
        <property type="nucleotide sequence ID" value="XM_014693519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU61"/>
    <dbReference type="GeneID" id="26238449"/>
    <dbReference type="KEGG" id="mbrn:26238449"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="142"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="612" mass="67681" checksum="5B14AB4CDED582E4" modified="2021-02-10" version="1">MQLEPATPYATQLNLNVRPWQQHLGRPTTLRPLLQDITASSRVSECHAASAQPELAMTTTSATPEASKARTGALRHKPTASNASRAAMPTNRRLNRASTVDPLSDRATQALIRKVLLPQESGDKGRDSQTPIEELLPPLTSRNDVDLQLYAFLAIILREFVQSWYNRITPDESLVAEILHVIAHCTRALEQRLRKLDLESLLLHEIPEMLDKHITTYRSTHPESPTFQSTFVNGREAYHALWPLPLLSPVPISGDPITTSKQLRNEAAYRQLLVQAVLTVLLPTEDLENPCLTALVEQIFSELIIGNAIANKAVQPWLLFEAICIVERVLTDKRWESNGLKASGVKIHLGSPRSWSVQGFFVSIIQFALISMSAIRFAFNLITMSSSLPPRGPVVSDKKLAPEVSVAKGNTSQDTQSTPPKVPVLSFSAWGCLGNVIELQRRMPWLGGFFSLLQLGVIHGPGRVARLDGVLDRFLSHRIQLLFSASHLPPVLQMLRGVLFPNNAPGSSSLLPPSSDRELYALRRRAARALWNMAPQSVSRLYFGGGLGAAMGQLAEAEEEEMVDELEGLLGVLGDEYCNKHLVYSVLELILVRLMPELCDNGVDDLLHERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU72</accession>
    <name>A0A7D5YU72_9HYPO</name>
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        <submittedName>
            <fullName evidence="5">NAP1-binding protein 2</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">NBP2</name>
        <name evidence="5" type="ORF">G6M90_00g058540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU72"/>
    <dbReference type="GeneID" id="26242842"/>
    <dbReference type="KEGG" id="mbrn:26242842"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NAP1-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="70"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
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        <location>
            <begin position="438"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI69161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="497" mass="53881" checksum="65E83347A48E53C5" modified="2021-02-10" version="1">MTDASSSPVSQPQGSSPAANANQPALPPLTTSTPTPSHRSNLPRPMSHASKSRLSQYSSGSVPSRSRPGSHMFPLFPSSLSYTLVRDFAYPAAHPMHYGPPPEPSRPPSGLTTPASETRRLSDPPASWEPRMPWDSWTSDGFSRGHDIPPIQFGDGPPYSEDDDLQSPVVATRHRKHKSSSATLGQSRGRAGREGDIMGTTNYDSERGYYVGTSGDGSERYYVTHGGEANGPGGEYVTYPPDQARHGHGYHFPQQGHQRDCGRPGSENCSSPSSSGYHDLDESRYSRDYQFTITSPDEEFHGKAVALFDFERENENELPLVEGQIIWVSYRHGQGWLVAEDPKTQESGLVPEEYVRLLRDIEGGMNSLTGHLVDACISLNEAETPTQAEHGGKERQPSITSTNGYHQPVVSVFSTSSKDLNPYPTGQLGIQAGQTPPQVIHYHGQRGGSQTSTPTIPQHNEPGMARRGSQDSTNDGEAGTTPVQEHPTATSSQAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUU0</accession>
    <name>A0A7D5YUU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g005260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686687.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26245204"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
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    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="VASt" evidence="7">
        <location>
            <begin position="764"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1123" mass="120719" checksum="F1DFCF80F01BCE9C" modified="2021-02-10" version="1">MDGTTASSGGLRVGKLLPKGLSAKRRRRKDKNGRDSEASGADDDTRSTSAHSSQRRFKRELTLESDDANSTNIADDDDEMDDRSFGSFESGADPETADRGRPASSSAPARPATISAHPSLIGYLTTSSPVVQTQHLDSRSHFLSSSQARGYSSGSSDKSLSPEKPSKAKGVPGFQNSIPEPPAPAKIASADRKGRASTPRIETNPPRTPPQDDKPAPVIVNTPPTPTDRADHSQFATSPDGRPSTNGADPKLRADGSAAASNMNIHRRSKSGSAAIGPSKLSHITAAPLTPTDETGGETTPSATGFFSSMISAAQNAATSISNTIPSTGLGIGSNKTRNGTPKSLNSPAASQTTLNSQPAPEPEPRIEDTMDRKESAVRTLGSGDLSLSQLGLPESSITSPASARFADVADTRTRSESAPTEPQTSATDVLPAESSSRPRSLAEPASGDQTPPQTDLSDLKGPVQRSSSLRSAMKPHRKRGSSATTGGTIAAAITSATNAALPTSGGIGAPKLTGFAIASKKRNRDFHNLFKSVPDDDYLIEDYSCALQREILAHGRLYVSEGHLCFSSNILGWTTTLVMSFDEIVSVEKRSTALVFKNGLMISTLHAKHIFASFTSRDATYDLIVNIWKLGHPTLRSTLNGVQLEGTGGDKTEKVEEQQGVMEEEPQEASGSEDDTDDDEGDDEEFYDEEEHDEVLETQSTDMTAVEPDPERPATRKVSGMTAVNGVASEPSKDASPPPGGAPDFPGPSAHAPTDCGDSTAHYEKVLGDEIIPAPLGKVYNLVFGPGSVTWMNKWLSTEQKCTDIQMEDKKGLTADNKSRTFTYIKPLNGSIGPKQTKCVVTETIDQMDLEKAVNLSVSTQNPDVPYGNLFTVKTKYCLSWAENNATRIQINCTVDWSGKCWLKGTIEKNVNDGQGQYCKELFASLKSAVSSRARSGTATNGIVKGKKKLKRSKALQTVVDLEASKGGKSDGGKQNWGPLEPVRSILEPCVDVLQPILTGNVMYGLLVGLLVAMWFGFGSPPKNNAPFGPDVGFYSPNRQAAYEEMWRRQDSELWEWLEERVGMERLSSDQPSARKRGMEHRTVEDKLREERMDEREIQEAIRVTEEKLRVLREVIGKGRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUU3</accession>
    <name>A0A7D5YUU3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g048720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544985.1">
        <property type="nucleotide sequence ID" value="XM_014689499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUU3"/>
    <dbReference type="GeneID" id="26242326"/>
    <dbReference type="KEGG" id="mbrn:26242326"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="108" mass="11375" checksum="73D1BF6546ED0813" modified="2021-02-10" version="1">MSAANTTGPSPTFYSSSSSPETPSAPSPNPNGRALPAPGDSATTLDVSGDGTTVKLDHLGPLVVNVDGTLSRISNWSEMAEVERQNTLRVLGRRNKQRLEALRKAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV13</accession>
    <name>A0A7D5YV13_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-induced GTP-binding protein Mx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mx_0</name>
        <name evidence="6" type="ORF">G6M90_00g054400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540964.1">
        <property type="nucleotide sequence ID" value="XM_014685478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV13"/>
    <dbReference type="GeneID" id="26246270"/>
    <dbReference type="KEGG" id="mbrn:26246270"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="29"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="597"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="719"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="886" mass="99720" checksum="0478084478441E55" modified="2021-02-10" version="1">MAFIELQSEDHRDLLDTFDRLRSGGVCKHVHLPEIIVCGGRSAGKSSVLEAISGISFLTEDNACTRFTTELVLRRQDTPAAKISINPGLERGANEKRRSGIFTVPVSFDKPDIETIIGEAKEAMGLSDAKMFSSDILRVELCGPTQPHLTVVDLPGIFRADGQDEMAQDAETVRALVRHYIKRSHSIILAVVSAENYSYLGDITEIVRELDPNGSRTLGLITKPDVLEPGSDRESVYAHLAKNTELSSQLGWHVLKNRDHKVRDSPSLGRNEDEESFFSKGIWSSVDQSYLGIKSLMPRLSNILRNQILQQVPSIIEVVDRDIDRRKAQLERLGKPRCTISEQRKYLMQVSREFTTLMKAAVDGEYNDAFFGSAKSDEGYRRRLRARIQNTLTSFEKEMREKGQSRVIVDDSGTRDRKLPNDHQWRSTFVNEVMAIVRRSRTRGLPGTFNSQIIRELFVDQCQPWQTIAMNVKHEILGIVDDIAQAIVDHVAADETTRGVYHLVSNETDSLKADLGAKFHEILKQYVCSHPITYNSYLLDMVQKEQERRTHEQIEETVKKLVGNENFKEEHRVKIHPLNLCDSLKRSINVDMERSGAEMATDYMLAYYKLALEKFVDDISVLAVEQCLLEKLPTLFLPEAVMDLPDHDVRYFIRERDTAHAERARCADKLAVLETERRVLARLDTRRSPGVAQACAGENLPVPGIPRSYTTDTVTVDEARPYFPRSPSPGNPGHSGELLVEPEGAEPAGAEPCAPEPEPVPELEPETEAAEAVEEPEEPAADEPMSTETPTDETQPAAEEAEEDLWGFRAKKEKWRRSWGDAQEEVPAVPLETEDAKSDLAGGKKSKRTKRKKSREDAPALSEVTLEIEPVIVPEEQLAYPWGWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVB8</accession>
    <name>A0A7D5YVB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cell pattern formation-associated protein STUA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">STUA</name>
        <name evidence="11" type="ORF">G6M90_00g076040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545496.1">
        <property type="nucleotide sequence ID" value="XM_014690010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVB8"/>
    <dbReference type="GeneID" id="26241529"/>
    <dbReference type="KEGG" id="mbrn:26241529"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="115"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="631" mass="67806" checksum="58C40333A09A7E77" modified="2021-02-10" version="1">MNHQNPEMYYPQHISGGQPPPPQTVTSNNLTSYQHPPHLMQPGPSNYSNPNPYGQYPQYANGLTSPSAAQAVSNPMGAAPSVLPLPGVTGQASMANHYAGFDTTGQNPPPGMKPRVTATLWEDEGSLCFQVEARGICVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKVRHVVKIGPMHLKGVWIPYERALDFANKEKITEMLYPLFVHNIGALLYHPTNQTRTSQVMAAAERRKQEQSQIRPPPPPPGLPSIQQHQQMALPGSQTSLPSHGGMGSRPTLDRAHTFPTPPGNPGVGGMGASDNFGWQGQAMNGAQGTNPLAIETGLNSTRSMPNTPATTPPGQPIQNMQPYHQASQGYDNSRQMYGASASQQSPYQNANPANNDRIYSQPSSYPKSDMGPPSSRPAAPGQPTEQHDAKSTNGIMQSEQSAHGHEEEGEPEHEAEYTHNSGVYDASRSSYNYTAPSVGNLANDANINPDMTGSPGHPSSSGRATPRTAAPHQSYYPQNNGYNTPPRVQQTTSNLYNVVSNDRGQTNAGPGGDVYAPAADMPNPMPNGYAPQPPLMNGASGGMKRGREDDEDLSQSGSEANGMSNGDLKRRRTIMETTVPAPAYDALNRPAPAMTAPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVC3</accession>
    <name>A0A7D5YVC3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Seipin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SEI1</name>
        <name evidence="9" type="ORF">G6M90_00g039360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547290.1">
        <property type="nucleotide sequence ID" value="XM_014691804.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26239853"/>
    <dbReference type="KEGG" id="mbrn:26239853"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="382" mass="43085" checksum="28EDF24A89520258" modified="2021-02-10" version="1">METLEETARVITSKPAQRAAVNVALLVSSAVTLFGLASLATALFFQNFVPDQFITTPLYLQYQSGTNPYGVAPLTYPSPKLQQDYDISLSLSMPRSPPNTERGNFMVSLYLVKDSVNDYKSDSNGRKTLDDRHYLEAKKVLFKARRSALMPYEDPILSVAKRVLFMGYYLLLPRSQARSLTVELAERVSFDKSALQPTAAFIEIEAGQDIQIYSASLTLTAQLRGLRWLMFHYRLITYMTFTFLFWVCEVLFMCLAWAIWSATTTPQDGRNMGITFRDGEGDDIDDEHDDHPDRTAGPVAHARYARIQREPEIKKEEEDEEPQRRLIYNIPMGEAEADDEDGFDDGNIVDGSGSRGDSGIGTSYKEEGSESLRRRASRDALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVC9</accession>
    <name>A0A7D5YVC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g096170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987603.1">
        <property type="nucleotide sequence ID" value="XM_066131505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVC9"/>
    <dbReference type="GeneID" id="26241138"/>
    <dbReference type="KEGG" id="mbrn:26241138"/>
    <dbReference type="OrthoDB" id="4934756at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028821995" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="447"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="579" mass="63809" checksum="4E6D3B1AA6563CEF" modified="2021-02-10" version="1">MGTFIRVLGWATLVSIAISVNTDTSDFDWNAVEPSWHLHYSPCYDGFQCARLLMPLDWLNTEPSNETVALSMIKLPAAVDCSDASFGGTVITNPGGPGSSGVRHVLKNGRYMQTMMDGEKHFEIMSFDPRGVAHSKPAADCYASEPARTAAAWQSRGFTNFDASAENLKYQKAFAAARGLQCAKPGPHGYAIQEYMATASVARDMVRIIDEIESLRQKTLAQKLQHEAQKPVTSKPANVARLQYYGTSYGTFLGNTFMSMFPGRVKRMVLDGVIVPEDWVAADWHNSLLDSEKALEYFYRSCFEATAKCPLTKSSDHSWHSIRDRVRTLLGELEASPRPVLTQGGTEAIITAGMVRSSIFNALYQPVDKFEPLAESLASALQGNYTLLVQNTGLGHPADGCTPKKPGEYNWLGLSSSAVVCGDAQDVTHHDERYWQGYFEKLGDRSPEFGHHVAKIPFTCSGWKSRPKYRFTGPFSSPQADTSDKQERPSAPALLLSSWIDPITPLQNAHRVSKSHPGSRVLSQRSVGHCALYSAPSKCTNRVVRTYMATGALPDEGAQCEPDCVPWEQCDDERTSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVK6</accession>
    <name>A0A7D5YVK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pumilio domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PUF1</name>
        <name evidence="7" type="ORF">G6M90_00g035090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546903.1">
        <property type="nucleotide sequence ID" value="XM_014691417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVK6"/>
    <dbReference type="GeneID" id="26239466"/>
    <dbReference type="KEGG" id="mbrn:26239466"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="567"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="593"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="629"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="665"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="774"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="810"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="846"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="908"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="913"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="987"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114163" checksum="E4392AF8A8298B9F" modified="2021-02-10" version="1">MDDVRFRSQHSPRNEASMAGFVSPPRNNGRISQHTSHDQRGNMPRRFTTDSGRVPTLSSMTAALTSPPRGLGLDSAPDYNNALHKVQLIEQKKLEYERIREQRRRFELEMQRLDQQQRREAQELAQMEEEIRIAGHQSEPTTPPEYRDNSGFPSIFSRPNRYSTSSLASPPGFNRPARSGSQLTSPPSGLTQQRYAFDERAMPSRSDPNTRRNSDDEEKEEAVRQDPTSHRSTNALHRYSMPVTRSRNGLYDMNLDQTNTTRFLFGDDEPNSLPRGRTPDDNFPTLVRREDQMLSASSAALDLALSPSPNPEKSNGWNRVNRHRHQQSMSAINGSSSSKSNEVITIGSRPQSLRHSLDLKYISESPAEPSSVAMSPQSSHMASPPRLQSSFSANDVPTVKNTSGSSILSGNANNHAQQHFHNHNASMGRIPAGAMPSRHNRELSGDNTMNNGREQSNGFQSIQSALQASAAPFGPSLTTAVQVSSATAVSGPSTTATASSFNNFYTPNGYGSNAAGSSGSFGMPMLTAGMQQMSMNGVNGANLYPAQNYTGYGSLSYNQGAGQPRDSQARVIQHRRQLDNEAMSRYQNMPLESFRGQIYELCKDQHGCRYLQKKLEERNPEQVHMIWLETNQHVIELMTDPFGNYLCQKLLEFCNDDERTVLIQNASQDMVRIALNQHGTRALQKMIEYVSTPQQVHLIIEALRFRVVELIQDLNGNHVIQKCLNKLTSLDAQFIFDAVGNNCVEVGTHRHGCCVLQRCIDHASGEQKPWLVGRITEHARILVQDPFGNYVVQYIIDLNEPSFTEPMVAMFQGCISQLSRHKFSSNVIEKCLRCSQAPSKDMIVEELLAPQEMERLLRDSFANYVIQTALEFATPHQKYRLVESIRPILPQIRTTPYGRRIQAKVSAYDNRGSAASSGQVTPAENTQGQIPLRQGHNRGMSGNASMLPSNGITNGGLAGLGANQGVRQGVASYPNSSVLTVPPPSGSAPIQQPQSQQQQQSQFNQRAPGSFTPSHSANASVDASGETRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW09</accession>
    <name>A0A7D5YW09_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g077300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545371.1">
        <property type="nucleotide sequence ID" value="XM_014689885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW09"/>
    <dbReference type="GeneID" id="26241404"/>
    <dbReference type="KEGG" id="mbrn:26241404"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26021" checksum="62B6C9DA9A33D18D" modified="2021-02-10" version="1">MADISESLVASLAETLDAAGAPCILWGQFLLNVHGIPSTIGSIDFIVPESRLAEAIPALENARNLSHCPDKNACPWSPQRRKAIEPVFHMHLGDSARTVTLYPHCQILWFLPQMNSSLPSSGQPQLELPQHLTLASSSTDLPPRRPGRGSGFFTTVEYPVVVLRLHALLEAYIRLYLRDRKRRDGAYARHSVKLLTPCIDDEELPGSREISDRIKRYYKTLANGDEIVLGRSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWN7</accession>
    <name>A0A7D5YWN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g035650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546960.1">
        <property type="nucleotide sequence ID" value="XM_014691474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWN7"/>
    <dbReference type="GeneID" id="26239523"/>
    <dbReference type="KEGG" id="mbrn:26239523"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="563" mass="63714" checksum="54BEA94086903976" modified="2021-02-10" version="1">MPLEQTITIVNNSGKIISTGKQLFSIFKEAKASYDEKKAEIRGLKRAETFDQSQIPYRHDGYSRPRGHGSHSGRSVYEPEYYTEYDYGKNPGSYDGRRQSFDVYSEAGSRRSHHTSRSHSKHYHHSERNRPALTENNLKTLSEISSTTPSRPPMTYRSPYAETLPKDMAVSRMNLAQYDMKSIVEDDWRQSALLRRASESQISRRDEPKDKEIDMNLAYGNIPPDLEYRVDLDPSSQGEEHKANQLVRKVEGLLDEAHCLQHSATSIIKHLQQKPDSAAAVALTLAELSSVVGKMSPAFLGFLKGGSPAVFALLASPQFLIGTGIAVGLTVVMFGGWKIVQRVKESQVPREAIAYESAPMDRPAPLRTQSDYNASFDEALIVDEELSTIETWRRGIMPFGVDNESADIELITPEAERAQREKHKDDFDLRSFRSAHTAARSTKTAKTTKTTKTSKTAKSSKTTKSQKTSSKDKEREVPERRSSRNPTVESINGDSELGRHRSSRKERERDRPREREVRMIEDGRSNNMDIVFRPKAQRQGDNMLKALFKNKDRHESNAEYVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5YXA5_9HYPO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131397.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90968114"/>
    <dbReference type="KEGG" id="mbrn:90968114"/>
    <dbReference type="OrthoDB" id="4955573at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="102" mass="11256" checksum="6C9461077D9CE379" modified="2021-02-10" version="1">MAPSFGITPRGFVPPPRRHDLRVGFTTSVFTARDVVSDGSDGGVYHIGVPSKNVPVARAASEEHLDVEVSLHAWKDQKYLNSWIIGDIQRWGTLSEEVRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYZ8</accession>
    <name>A0A7D5YYZ8_9HYPO</name>
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        <submittedName>
            <fullName evidence="5">Acetylxylan esterase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">axe-2</name>
        <name evidence="5" type="ORF">G6M90_00g110570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26243189"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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            <begin position="1"/>
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        </location>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5YZD4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g036800</name>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="AlphaFoldDB" id="A0A7D5YZD4"/>
    <dbReference type="GeneID" id="90967621"/>
    <dbReference type="KEGG" id="mbrn:90967621"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="52" mass="5525" checksum="F9B4E0660EE8B870" modified="2021-02-10" version="1">MIASADCLPGTASKPGESAGQFMVLLGGLNPEKYNNRGRALPNEKHKQISQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0E2</accession>
    <name>A0A7D5Z0E2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g002330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    <dbReference type="KEGG" id="mbrn:26244220"/>
    <dbReference type="OrthoDB" id="10314383at2759"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="84" mass="8170" checksum="9E0C074723B96501" modified="2021-02-10" version="1">MACLAVSSPTGAKPATENTDAGKTGKEIGESAGVLGDKIAGGNGGEIADASLGLAGSILDTIFGKGNKEAREAFVPPVSNPEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0N1</accession>
    <name>A0A7D5Z0N1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g046240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544751.1">
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    </dbReference>
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    <dbReference type="GeneID" id="26242092"/>
    <dbReference type="KEGG" id="mbrn:26242092"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="723"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="645"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="782"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1004" mass="110070" checksum="61801D3CF539B3FE" modified="2021-02-10" version="1">MSAADSPGSRPGPDKAIDEAAAERKQQLGRPARSRLPGWLNHFNANDLKVAFRCWVAVWVATILIFIDPVLQNIGIATFFGAIVLYIVPPAGILMVYLLASLSLLLGMCLAWAWGLLSMKAALAVRPDEETQARLQSLQQQAGMLANQTGQPPAAIVQKLVYDGFMLDARVVVIYFVMCCVFIYALARLRYANGKMILLQLFGTIVIDIFLLTGPILTRFNSKLAQVFVKPGAIGIGLGAVCCLFVFPQSTSYVVLGQMEQLIRMLEAPVDSTRRYFAGDETLDDAQLRASKGSIISLFKAMEPGLAFLPLDLSRGRWNADDVKCLQRRVRDAIAAGVFLLDFHITRVSAAARAERLGMAQPTPTAQDPDDGSDKEKTSFDTGLVDALKSPEQSSIRHGLLETLKDTTAEILQVNSRAIKAAADTVHIINTGRWYLGTARTKRLDGLKEELAGLRAELQSVRESCVINTNDAVVGAHADLFDEQGQLKNRKDTNPLSLNGIVLAMVLEERIVATAATTEAIVDYIMELLELRTTTRVWAPSQLRYAFSWLFSGRVAAPVAGASTVPAEDPDDILEQAEETHRRLRLVRKGNAAPRKQRGFLTRAVIGTYKWLTNPGGMYALRMVIVTVALSVPAVLPNTAGFFYREKGIWAVIMAQTCLLMYMADFTFSLVSRGLGTILGGALALAAWYAGSGNGIGNPYGLGATTAVVSFILMWWRLYLPPAFAQASIMTASTFVLIIGFSWDQNHVTQYGLPGVGYVAFWRRLVTVLVGLAAALIVQIFPRPPSATRYVCKTLANTVRSLTDHYALLVSQWSQSDREGQNLGAAAAAEKITLKVSETLLDLTDAISLLKVEISSTPFDQKVLFTTREHCSRMNQCLGKLLVLSSTLPKRLQDRLTKTVGVIDDGVVGNVMSVLTIIESSLRTGAPLPERLPAPLVRSCFVTWYTQHERAELNIDLIKSEDYRRYCVAVSCYVTFLSTVDDLVDALKETLGEAHVIHQWEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Q1</accession>
    <name>A0A7D5Z0Q1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lxr1_0</name>
        <name evidence="4" type="ORF">G6M90_00g029580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541213.1">
        <property type="nucleotide sequence ID" value="XM_014685727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Q1"/>
    <dbReference type="GeneID" id="26245848"/>
    <dbReference type="KEGG" id="mbrn:26245848"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="266" mass="28306" checksum="62C010E6DDC6B3BF" modified="2021-02-10" version="1">MPVSVPKTDRLVDLFSLKGKVVVVTGASGPRGMGIEAARGCAEMGADVAITYSSRKEGAEKNVEALTKEYGVKVKAYKLNVSNYDDVERCINGIIGDFGKIDGFIANAGATADAGVIEGTAAAWDKVIQIDLNGTAYCAKAVGAHFKKQGHGSFVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFIDPKTQELWRSMIPLGRNGLAKELKGAYVYLISDASTYTTGADLVIDGGYTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1B4</accession>
    <name>A0A7D5Z1B4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g000200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985738.1">
        <property type="nucleotide sequence ID" value="XM_066129481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1B4"/>
    <dbReference type="GeneID" id="90967386"/>
    <dbReference type="KEGG" id="mbrn:90967386"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="57" mass="5788" checksum="11D87A125B933992" modified="2021-02-10" version="1">MAGQGSGDSESASACPAEKEVAGNNWAPPSDSKMNTSEEMKNACASSRIATRSIGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1D4</accession>
    <name>A0A7D5Z1D4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g016490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548881.1">
        <property type="nucleotide sequence ID" value="XM_014693395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1D4"/>
    <dbReference type="GeneID" id="26238325"/>
    <dbReference type="KEGG" id="mbrn:26238325"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF29">
        <property type="entry name" value="BETA-GLUCOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029004858" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="808"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="746"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="887" mass="96147" checksum="09734746F86EBF84" modified="2021-02-10" version="1">MTRALVVVGALVALPSSIAIGFDDFYDFADTQILLQLDARAELATSPPHYPSPWMNPQAPGWEDAYKQARDFVSRMTLAEKVNLTTGTGWMSDNCVGNSGAVPRLGLRALCLQDGPLGIRLSDYNSAFPAGITAGATWSEHLWRDRGKALGAESRDKGIDIALGPASGPLGRAPTGGRNAEGFGSDPYLQGKGLANTVIGIQESGVIACAKHFIANEQEHFRQAGESVPRGFNISESLSSNVDDKTLHEDYAWPFADAIRAGVGSIMCSYNQINNSYACQNSKLLNGILKDEMGFQGFVMSDWQAQHGGAATAVAGLDMSMPGDTEFNTGYSFWGGNLTLAVINGTVPAYRIDDMAMRIMASFFKVGMKPGKQVPTSFSSWTRDTFGYRQAAAKENWEQVNFQVDVRGNHAAHIRESAAKGTVILKNTGSLPLNKPKFLAVVGEDAGQNSRGPNGCDDRGCDDGTLAMLWGSGTSQFPYLITPDSALQRQAIQDGSRYESVLSNYQWAATQRVVAQPNVTAVVFVNADSGEGYIEVDGNAGDRKNLTLWKNGDDLIKNVSSICHNTIVVIHSVGPVLVTDWYQNPNISAIVWAGLPGQESGNSITDILYGKTSPGRSPFTWGPTRESYGTDVLYKPNNGNDAPQQDFTEGSFIDYRHFDKVAPGKNSTGAPIYEFGYGLSWSTFEYSNLKVEKRDVRPMSPPNGKTIAAPTFGNFSTNLKDYAFPPSIRYVYQFIYPWLNTTASGKEASGDPHYGQTAEQFLPPGATDGSPQPRLASSGEPGGNRQLWDVVYTVSATITNTGKRVSDEIPQLYISLGGKNEPVRVLRGFNRIEGIAPGQSVTFRHEITRREISNWDTASQNWVITKAPKKVFVGSSSRHLPLSADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Z0</accession>
    <name>A0A7D5Z1Z0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g053960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986685.1">
        <property type="nucleotide sequence ID" value="XM_066130575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Z0"/>
    <dbReference type="GeneID" id="90967788"/>
    <dbReference type="KEGG" id="mbrn:90967788"/>
    <dbReference type="OrthoDB" id="10440236at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029006727" evidence="2">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="85" mass="8783" checksum="7DCEF8022F19BE8B" modified="2021-02-10" version="1">MKVIGVLSAATALLGLASAAPYAVPDDDGVRANAESPDGTRVTRDGETGAEPDGTRVTRRDRVDDVGPDGTRVTKRGGEEKANTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3K6</accession>
    <name>A0A7D5Z3K6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LEA domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g104060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541402.2">
        <property type="nucleotide sequence ID" value="XM_014685916.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3K6"/>
    <dbReference type="GeneID" id="26245652"/>
    <dbReference type="KEGG" id="mbrn:26245652"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45426" checksum="F9AE26421EECD7B3" modified="2021-02-10" version="1">MYRDISKPPPPLPSPDLTALDEGIHLLKPLSRRGEGPGLILVTPDYVGHLTITNGVPSPILKWAEEGYVVAEVQESALRRRGGQAITMALEAIATCDKCNSRPPEAWKVVAPTLAQFEQIVGAVVYSRAGDDDPASASIPVLQHLAGPGDNSRSPCLTVYFYPTAKPGFAVPSHPNFRYNAESLSHTRNLTFLKPLMNGPYFDLEKIWDEHTYYEFADRSVEHTMSTMVAEPYVNHVPTLTGGIGRERLTEFYRNNFIFCNSANTHLELTSRTVGLDRVIDEFIFKTTHDQQVDWLLPGVPPTGRELEIPFTAVVNIRGDRLYHEHVSWDQGTALRQLGLMPEYLPFPYALPDGRGPAAGKRFEYKVPVLGVETANKMRDKNSVESNGLFGGEYLQDRDGSAQYIINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3M3</accession>
    <name>A0A7D5Z3M3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PFDN6</name>
        <name evidence="4" type="ORF">G6M90_00g047670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544884.1">
        <property type="nucleotide sequence ID" value="XM_014689398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3M3"/>
    <dbReference type="GeneID" id="26242225"/>
    <dbReference type="KEGG" id="mbrn:26242225"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="125" mass="14036" checksum="1E9DACCF2E9ED0BE" modified="2021-02-10" version="1">MAEIQAKLQTLSDEYQKLQQDLQNTVNSRQKLQSQQQENAGVFKEFEKLGEDETIYKLMGPVLLKQDKVEAESTVKGRLDFIAGEVTRLETQIKETQDELEKKKAEIIQIQASAQAAAGGKGPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3S3</accession>
    <name>A0A7D5Z3S3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kri1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kri1</name>
        <name evidence="4" type="ORF">G6M90_00g086540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542460.1">
        <property type="nucleotide sequence ID" value="XM_014686974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3S3"/>
    <dbReference type="GeneID" id="26244974"/>
    <dbReference type="KEGG" id="mbrn:26244974"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="496"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="651" mass="74637" checksum="12C873F59710BE54" modified="2021-02-10" version="1">MALGTEGPSNGPKPPKRNLLDDGDSDSDGGAQLEKSDLKVNEEYARRFEYNKKREEKHKLEEKFKNSGKGQDDDDDESSSSSNETEDEDGFLATEDLDAQISATLHAIRNKDPRLYDKNYKFIDLPDEDTAGTKEKKEKPVFLRDYHREKLLQGAAATSDGEEDPVPQTYAEEQDALRKSIVSEFNTAGAVDDSDDSDSDGFMKKKAPAEIEKTENGVHPARAAALKISDLDIVNADKDPETYLSNFLSARAWIPEEGGRWKAFESDEGEDDDRADEFEQAYNMRFENPEKSNEVLQSYARDFAAARSVRREEKTGRQRQREIEKQKKEEEKRQRREDKARLRKLKLEETEEKLRKVKQAAGAVGKELTEQEWMKFLDEAWENDKWEEEMQKRFGDDYYAMEDNATAASDGGDDDIEKKKKKKKHAEKPKWDDDIDIKDLIPDFEVEDQAKLRISLSDEDDENQDSDAPPSKKRKTSEHKRARLESQKQARKERFKLEALVDAKLELDNHELLSSNSGMTFRYRETSPQSFGMTARDILLAPSDKDLNQFFGLKKLAPFRDPEKKHRDKKRLGKKARLREWRRGTFGKEFEKEGPTYGFEMVMDEEDVIMDGVPDKAVTGESVHVVGDVGARKKKRKRSKGKKKGGAVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3W5</accession>
    <name>A0A7D5Z3W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">wrs1</name>
        <name evidence="14" type="ORF">G6M90_00g012970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549225.1">
        <property type="nucleotide sequence ID" value="XM_014693739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3W5"/>
    <dbReference type="GeneID" id="26238669"/>
    <dbReference type="KEGG" id="mbrn:26238669"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="491" mass="54707" checksum="6C3F9D5AC1D31CE8" modified="2021-02-10" version="1">MASAPATVDHVGHVPVDDVASPEDTNPSKQDINPWSVSGEVGDDGKVKAIDYTKLIDEFGTSKIDDALLQRWEKVTGQKPHRFMRRGIFFSHRDLHMILDRYEKNDPFFLYTGRGPSSDSMHIGHTQVFDFVKWLQETLDVPLIVMLTDDEKYLFSEKRTVEEVMGYSRTNAMDIIAAGFDPKKTFIFSDFAYVGGAFYKNIVRFAKRVTYNTAKAIFGFDGSSNIGKIHFASIQGATSFASSFPHIFGHDEKKTSSIPCLIPCAIDQDPYFRLTRDCAQGLKFAKPALIHMRFLDALQGPGSKMSASDDNSAIFLSDTAKQIKNKINKYAFSGGRETLEEHREKGGNADVDVAYQYLTFFLEDDDELKRIKDEYNSGKLLTGELKAICIEHLQKYVGTFQERRSKVSDAVVDEFMSVRPLEWKGNPRVPRADLVVPVTKTDGATPTGDAAGTGELSKNAMKKLLKEQQIAAKKAQKAKEKEAAAEGGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z431</accession>
    <name>A0A7D5Z431_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549888.1">
        <property type="nucleotide sequence ID" value="XM_014694402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z431"/>
    <dbReference type="GeneID" id="26239332"/>
    <dbReference type="KEGG" id="mbrn:26239332"/>
    <dbReference type="OrthoDB" id="4936392at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="155" mass="18187" checksum="B23DD69706E8F080" modified="2021-02-10" version="1">MAPGDGSDLFWYDGTIDADRRSPEPKDGPTFARAAQTFSSKRKASQFSLRSLTKSLSKRPRLVAFRQWAVNIYHDSSRRLTEAYRRLKYQRRFGEFRAWKGIGRRRQRPQPADDVKDKSAQPYGVFKYESGPGNQEWWKDGVTRYRAPSWMFRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5B6</accession>
    <name>A0A7D5Z5B6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g065040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986810.1">
        <property type="nucleotide sequence ID" value="XM_066130792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5B6"/>
    <dbReference type="GeneID" id="90967865"/>
    <dbReference type="KEGG" id="mbrn:90967865"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="14802" checksum="20CD4D3B518B8DC8" modified="2021-02-10" version="1">MTGLITTQGGKNPFWRLALVFKCAADTIFLDDFKTVLDHIAESAFQRRGFSGAKHDSRSMSYCSPQHTRNTTLQGSCSERTAHLPGMEISAVHGRDTFAGRYASAGPGIEFNHIEFGSESQRKKQSIIHTELPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5N4</accession>
    <name>A0A7D5Z5N4_9HYPO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g060790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5N4"/>
    <dbReference type="GeneID" id="90967831"/>
    <dbReference type="KEGG" id="mbrn:90967831"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="87" mass="9855" checksum="9469F3EA0C8382B3" modified="2021-02-10" version="1">MHQDLVSATNTDAQAREHELAMLRMQLTALRRSIYRLDGLQTTIYGCLVDLSNLISTLETTHDLLEHLHNVMDAEDVGGFQQSSDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z890</accession>
    <name>A0A7D5Z890_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g070840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987216.1">
        <property type="nucleotide sequence ID" value="XM_066130942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z890"/>
    <dbReference type="GeneID" id="26247861"/>
    <dbReference type="KEGG" id="mbrn:26247861"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="937"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1153" mass="122855" checksum="154B1F3BE287492B" modified="2021-02-10" version="1">MPVTKPLSSLHPVGSGAEGDKQQKQGTEALESVPRTVAGVINDKGEIIDKSGKVIGTVLDVKDHEKLVGDAVTDKGDVVSDLGESLANVHIDDNYTPTQVPAQVPEKKDAAAGWNVLGKARTAMQYGDSIRNAVSYGQNLQGAYSKFSQGQKPEADKTGEGVSAAREPAGGEDQMPTPVKMEDKDKPAQEDVSAETQGFKPQDLKGGEAVASAAEDKRAAKPAPGEPGEDAGEQIGSLAAQSPRPISEEDARDVPGSLKETVETASEGQKPLEEVKDVAGDDKLDQDKPAELEREEGQLGGDNLGQDKLEEAKPGEDTLSEAKDEVASRGESQLGKDTLGEDKVKETMPGQDTLGEAKDEVASRGEGRPDEDTLGETKSGEDTLSEAKDEVASKDQGQLGKDTLGEAKPGEGTIAEDKVQPGEDKLGEYAVGEARNEATIKTEEGRLGEDKFAETEPDKMTLDEDKVQPSESKLGEDTVGEAQGEVASKTEEGQLGEDKLDEAELKKRGLDEATGQPSEGALGEETFGEEAAGKPEEGQLGEDQLAETEPDKMTLDEAKDEATDKVEEGAEEAGETAEKPLDFTVLKGTKVNKAGNLVNDNGDIIGRLVDGDPKQLMGRTADEEGQIWNESGKVIGKAEPISDADRDEAAKEFAPFENFPDAVVEGDGRVVSEGRQVGEVIEGDAKRMKGSRVDEDGDILDRRGNVIGKAKPWDEPEEIPPEVIDMSSLAGKRVNKAGNVVDAHGQIFGRVVEGNVKALIGRMCDKEGNIMSESGEKIGRAELVPESEREGSREGPFAELSGCTVTRDGKVVTPSGDVVGRLTSGDGKVLYGRAVDEDGDVVDKNGNVLGTAERWEEPVVEKKKDPLAGRRVNREGNVVDEDGNIIGKLVSGDLNICSGKEIDDDGDVINSKGMAIGHVSLLEDIPPEPEESAEDKEKREQAEKDRKLAGQLAASIEQSLDKIKPILRMITDKVDRAERTPKEELDEEQLVREVKPLIEEGSKILTETNGVVRGMDPDGRIQRQAKHKASTKDATPEEHHLAEVIKELTGDVTQTIDNAKRKIEGMPHAKKELNPLWGLLSEPLFQIIAAVGLLLNGVLSLVGRLLSGLGLGGLVDNLLGTLGLNRVLDGLGLGSVTSALTGKKDKDKKKTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9E0</accession>
    <name>A0A7D5Z9E0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g072090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987194.1">
        <property type="nucleotide sequence ID" value="XM_066130964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9E0"/>
    <dbReference type="GeneID" id="26241886"/>
    <dbReference type="KEGG" id="mbrn:26241886"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UQ_con"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="822"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="793"/>
        </location>
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        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71208.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1009" mass="112937" checksum="E72B175F2A1C228E" modified="2021-02-10" version="1">MSSSARAFLADLAKARETQYDSISGIRRGDSDGEVSLLYSNDSLEEPLEIKILSMDVTSYPDDSCFMVFTSSETCDTKVLSLLELISSSTRGSTLHEVIQTVSDQLTASFDDTLESGFGSSASPDQDTPDYEFYDSFEISDDEAFPQLEKSRADENNMGLTGAGHEIPISTHAPSSLQHDFALDDEASISFPLVAMQFALRRFCKCTEYCIVCHLKLQTDFVPLKPYVCTKDLCLYQYLALGLGPNIEHEVISSPYVVDLLISFFYSGETQRSIREFPCGLALRAPVIQQSAPHLEIETCIQSQQFRILRAKNEPMGTNIRKRMRNGDWFAMLTNKAGSIEKHTCYVSETLDDGLYKYETTNSIIWPKNRAEISISELIFSTAVPSKKDFWQSGFIFLYEHDVDNLDADQRAIALTELLDNLPSVLEMRSYLLDEPGRMLSSWKRINTSALSLMRWIVASNTSYIVQDGPVPSKDLAAHSSNQNPPSAAMRKATSNLIRPLENGWMQFRFAQGSPEKEFAFLKTLQEMKSKNQSTVKPPSLFVWHGSPISNWHSIIRAGLDFQQTRHGRSYGNGVYFSKHMEVSKTYSTRLDFCAKAPFRHCWMGSELRISLALSICEIVNKPEEFVASHPHFVVDKEEWIQCRYLLIQIDPTENALKNPLFAPSGPECTGYIQQDPEHCIMNEYSMDPLQIPLSALSVARQQEALGLTLGNTALDSITAVTNKIDDESCDSESGDHPEILVDDILKLYRAHESRKRQRSTSPEPSSCGLASSPSPWKSTKWSEIGKKNTRSTQNMTVSLGSLDYKTIPQLPPPSWATSSPMALQTLTRELKHIHTIQSQNHAASLGWSVDALAIDNLFQWIVQFHSFDSGLPLAMDMKSRGLRSIVLEVRFGSNFPMSPPFVRIIRPRFLPFLEGGGGHVTAGGAICSEMLTNSGWSPAMSMEMVFLQIRLGLCDTERPARLDTRQRNADYGIAEAVAAYIRAAVNHGWDVPEDLENIHAGWWMPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9E2</accession>
    <name>A0A7D5Z9E2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g095200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546810.1">
        <property type="nucleotide sequence ID" value="XM_014691324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9E2"/>
    <dbReference type="GeneID" id="26241233"/>
    <dbReference type="KEGG" id="mbrn:26241233"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23390" checksum="975DB74590FA8E69" modified="2021-02-10" version="1">MIFALVFVCTRISQIVTLLPPMGMLAWFINIFISHNALTPDSILILFILVVLALAWAVFTLFSYHRSSANARFICLVDLCFMGALIAGVYEMRGIADASCSNPDSSSVWFAPNHIPVPNWGWQTDKPCAMLKASWAFAIMNIIFFATTALAAFSHGDHLAYEGRGAYVVERRHHHSSRHSHRHRSRSRSGGSRHSSHRSPHSHRRVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9T6</accession>
    <name>A0A7D5Z9T6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">DNF1</name>
        <name evidence="28" type="ORF">G6M90_00g091930</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541838.1">
        <property type="nucleotide sequence ID" value="XM_014686352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245306"/>
    <dbReference type="KEGG" id="mbrn:26245306"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1152"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1180"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1231"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1272"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1297"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1337"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="26">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="27">
        <location>
            <begin position="1117"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1390"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1500"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1430"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1441"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1504"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9Z6</accession>
    <name>A0A7D5Z9Z6_9HYPO</name>
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        <submittedName>
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        <name evidence="2" type="ORF">G6M90_00g086330</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014686995.1"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
    <sequence length="339" mass="36698" checksum="DAD9382E27CA6E0C" modified="2021-02-10" version="1">MPEAGTDLKSPKPRRPLPKADNPLSRQVHFDDPNSKTKPSSAAAQEPKNTQPDSHPQVGPPPLPNLNRPPSDQWFTAANPTRSINLPAAQPPYAHFPHLHPHPPFHQQSFVQGVTYFPAANMGDYQNCAPPPTGVNFQPPVPDTTFGPMPHVYVPRFDGGPVYGGGGVVHQPVAAAPQGYVVQPGMVPLAQQPVMLNPHAYVPVGAPGIPGQPMMSAAAMPAPMMAAAAAPGAGGGAIPIIPGNLPPPPPPTSTAMPEVSGMGRTPNEEMLRQVEFAYSNRLFEPQDFKPADDDPSRYYYVREVDGNWTQRNRFTIDHMGDCRWYVTDEGWFYAVRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA02</accession>
    <name>A0A7D5ZA02_9HYPO</name>
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        <submittedName>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
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            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF212">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029001764" evidence="13">
        <location>
            <begin position="19"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="14">
        <location>
            <begin position="31"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="233"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI71848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="460" mass="50149" checksum="B6CF203148709C77" modified="2021-02-10" version="1">MKPSLPTTLTLLAQLAHAADTNAWKSRSIYFALTDRIARSSSDNGGDPCGNLGDYCGGTFQGLEGKLDYIRGMGFDAIWITPVVANAAGGYHGYWAQDLYAINAHYGSANDLKKLVDAAHEKQMYVMIDVVANHMGPSALASRQPSPLDQASSYHPPCAIDYSNQTSIENCQIANLPDLDTQSPAIRRLYRNWIQWLVNEYAPDGVRIDTVKHVEHDYWAGFASAAAVYTLGEVFHGDPAYVARYAGSMSGLLNYPVYYPLTDFFQQRGHPQALVDMHDRVGAAFPDPSALGTFLDNHDNPRFLHQGGDAALLKNALAYVLLARGVPVVYYGTEQGFAGAADPENREDLWRSGFGTGGDLYGFIGKLTGVKKAAGGLAGDDHVHLFVDETAYAWSREGGRVMVLTSNIGRGHTREYCFFTRRPGGRWEGVLDGETYVADGEGRLCATVRDGAPVVFRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBT0</accession>
    <name>A0A7D5ZBT0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g114050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539705.1">
        <property type="nucleotide sequence ID" value="XM_014684219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBT0"/>
    <dbReference type="GeneID" id="26247536"/>
    <dbReference type="KEGG" id="mbrn:26247536"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="428" mass="47120" checksum="73BAFA7EF3C805D3" modified="2021-02-10" version="1">MNAASGTTTVLGSDSWIGADATQSDDAFHQRASAFVAAVKWDALLSISSHVRHGIPCKASDEFSVGHFNMVRRVVFDDQVSWVARLRMPPISDVPADREAASVARIMQVEVAGMRFLKAKTDVPVPKVHSYNTEQDNDVGAPYILMDYIHGNVASEMRLAKDCALGLYGTPEQDRSFRREMAMIQAVLATFTFDRIGSLYQDPATEEFFVGPDIETDKGPWSHSSDYFADVAEHALRVCVNNAAPDVLTGASLALPVIFTDLMKRFGGSNSNSSDGPAAPFCLTNRDLGPHNLLVDEEFHIVGVIDLDGIMAAPYEVAAQFPVLAGLDPEPPGHVETMPAALERIKRTEPLIREYNDMVKEIEECADSPERKIWNMMLSNGARVVQGLSQYKSHQKFVNDRWLDAYGRLLAECFNSTARSSFATKNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ71</accession>
    <name>A0A7D5UQ71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g010470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549471.1">
        <property type="nucleotide sequence ID" value="XM_014693985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ71"/>
    <dbReference type="GeneID" id="26238915"/>
    <dbReference type="KEGG" id="mbrn:26238915"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF13">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="621" mass="69020" checksum="4CE9C26E80BDBAEE" modified="2021-02-10" version="1">MPPQTHFSEDPPQVINQKDLELANERLKQSGSGNGLAAAGEGSGISASDETSSPPGTDGNGGAIEKVGTYDRYEITEDDCYDELGYSFPSWKKWYILTVIFWVQVSMNFNTSLYSNAIPGISEEFGVSDQAARCGAMIFLVLYAFGCELWAPWSEEFGRWPVLQLSLFLVNVWQLPVALAPNFASVMVGRALGGLSSAGGSVTLGMIADMWEADNQQYAVAYVVFSSVGGSVLGPIVGGFTEQYLDWRWSIWIQLILGGFVQLVHFFTVPETRTTIMMNRIAKRRRKETNQNVWGPDELVPFSDRFSAREILVTWVRPFRMFLTEPIVLVLSLLSGFSDALIFMFIQSFALVYGQWHFTTVQIGLSFIAIGVGYLMAWGLFIPAIRRNIKERKQKPDDERAQYESRLWFLLYTAPCLPIGLIGFAWTIQGPPIHWIGSMVFVAIVGIANYAIYMATIDYMVCAYGPYSASATGGNGWARDFLAGVLTLPAIPFFKNIGASSGKNLEYASTILFCISFVLVAAVYVIYWKGPELRHRSPFAQKLADARQTQLNEGRRGSIPYDPDERRGSATSAVNVRPGNERRYSQQHRFFGESRVTPRGTPRGTPSASRRPSMANLAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ85</accession>
    <name>A0A7D5UQ85_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g029420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985671.1">
        <property type="nucleotide sequence ID" value="XM_066130029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ85"/>
    <dbReference type="GeneID" id="90967562"/>
    <dbReference type="KEGG" id="mbrn:90967562"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="86" mass="9801" checksum="007D32A321E8EA02" modified="2021-02-10" version="1">MKVLLDADWGFRLEGVTYSKVKIRHGVRDRNMMCHFAGMMPSCTLYESNQDTHYTMGNDMEAALGELMGDPKAKNRSGMRLRTRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQY5</accession>
    <name>A0A7D5UQY5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g001410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542931.1">
        <property type="nucleotide sequence ID" value="XM_014687445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQY5"/>
    <dbReference type="GeneID" id="26244304"/>
    <dbReference type="KEGG" id="mbrn:26244304"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="279" mass="29780" checksum="FE2C651B111B3894" modified="2021-02-10" version="1">MPATWFLLPDFTFTADGPLRMGMVIPHWSRPTTVLADVASGAAGEIKLPALKTIVEPNHTHSRSRSRSDSLSLWSKFEGLASASAGAGVGKNNSVDYGKTDHEVRTFRDPLMPETVAAIANLPAVRAQIDSGVFGKRPVYIVSGLRIATSSFTVARGQGSDFTMEAAGSGPPAGTIPAEVGGRMKHEGLAKLTDSYDTASGVVFAYRLCVIRTRRAGVETEMFSHKSAFLGDAGKKEAVPLVFGEATKDEIDGDLEEEIEYESAEIGEDELCISISLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URZ1</accession>
    <name>A0A7D5URZ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Deoxyribodipyrimidine photo-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phr</name>
        <name evidence="10" type="ORF">G6M90_00g026000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547981.1">
        <property type="nucleotide sequence ID" value="XM_014692495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URZ1"/>
    <dbReference type="GeneID" id="26237425"/>
    <dbReference type="KEGG" id="mbrn:26237425"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000003">
        <property type="entry name" value="Deoxyribodipyrimidine photo-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018394">
        <property type="entry name" value="DNA_photolyase_1_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00394">
        <property type="entry name" value="DNA_PHOTOLYASES_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00691">
        <property type="entry name" value="DNA_PHOTOLYASES_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0157">Chromophore</keyword>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="93"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="345"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="486"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="7">
        <location>
            <position position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="587" mass="67356" checksum="C9374CE4C4DC4684" modified="2021-02-10" version="1">MARKSSKRKPSSPDHTNGNSAKRSRNANGLREPHPLAAEAERHGIVLRKYYPPEMSNARARAYNNNEIPRPMEDLVTALYNTTEQRQRVEAKDSVIHWFKTDLRCNDNRALALASEKAKEAAVPLICMYIVSPQDFEAHLTSPVRVDFILRTLEIVKRDLAKLDIPLYIETVERRKQIPDRILELMEQWGSRHLFANMEYEVDELRREANMVHDLAENGKSFEVVHDTCVVPPGQLQSGSGNQYAVYSPWYRSWVAHIHADLDLLELFDPPNKNPGTARKRFKDLFDCAVPEAPSNKQLTKEEKRRFHSLWPAGENAAKERLDKFCEEKIGGYSDNRNIPAQDGTSSLSVHLASGTISSRTCVRTARDRNKTKKLDGGNEGIRVWISEVAWRDFYKHVLVHWPYICMNKPYKPEYSNIAWSYNEEHFKAWCEGRTGFPIVDAAMRQLNHNGYMHNRCRMIVASFLSKDLLIDWRKGERYFMEHLIDGDLASNNGGWGFSASVGVDPQPYFRIFNPLLQSEKFDPEGVYIRKWVPELQDLDSKEIHDPYGRGAGAKAKKAGYPKPIVNHKDCRDRALNAYKEGIANGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USB9</accession>
    <name>A0A7D5USB9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iml1</name>
        <name evidence="7" type="ORF">G6M90_00g022350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548320.1">
        <property type="nucleotide sequence ID" value="XM_014692834.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26237764"/>
    <dbReference type="KEGG" id="mbrn:26237764"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045838">
        <property type="entry name" value="DEPDC5_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19418">
        <property type="entry name" value="DEPDC5_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1331"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="845"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1377"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1444"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1701"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="886"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1385"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1712"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1908" mass="213745" checksum="9DEF068A931894B1" modified="2021-02-10" version="1">MSRYAGPMPPVPRRGPRWSHLHHPGTVSFDLGSTESPSSPGSTSTHSTIREDTRRKTERHCTISVNDGYSKDEVLLNLDHLGGDIKPGALMALIPLKGDSKNATCGYGSVSKQPHEHLDSARAASGTYSDHDHGAGHTYIFVAKDMSKEMKARHPDAEVHVAKHIADAFFMRKGCHVLLRPVNQHHPAVEATHVEMSFKDQYLSRADMWRLAAGELTQRTVYKGQSLFFMGTIKAQVTAVYVNGHTVHSAFFGKDTRPIFRSESAKYVLFIQMAREMWDFDSEASGEIMFNKVVNGFLPALFKRWAVLKVKHLVSIVLFARVEYDTGISADLATSSLLDDYYTGMQPYGNRRPYKDFYRVVVSEMASGEWTTILYQLKREFNFFRRDITLHHQKISTFGHRPSDEDGAKDGISSPAKAESSLSIHGNVLEAINMAASQFSHDYIDRDLTRTGISIAVITPGPGVFEVDYETLRRTTESLVGSGIGIDLICMASMPLHSVPLFKYRNPQFSEDARHSQGHALSRSFHSRDSTPSHPTPVIGSYQSMSGSFSPTKAYSLAGRIETLALTGANEEYCYALPQWLHVSFWTGAAEESLSYAGIALTVSNKVEQEDKDWFKVRCRMYDLQMRSVLDANEIETAPLQSDSSYPSHLVQASAIAKKRPDRPGDTIYIPNKQAPETLFDHVYGFQKFVPDKLVRPGEKSVCKHLQEYDDAKARLPRARPYHQHQPSRNKPEFEDVARKQLNDDTSAMGTSLPERKASTYLQPSHMQASRKFSLTTTEVEKPILSAPKPSPEPPPSTATFKKAPSIKQPKFMRQISLGQRGFGIAAPKVVAAELKIETVGAAAVSSNLRPPSSAHSFSDLRPSTPQTITSRSSSASAQRQKYETAASTTDGVPSTPSIPISRDSFNRPGTAVSQVKSPSVLPVAASTRRERRPEDNDVRFSNALRAEDAQKVYTSKLRAGVVPELPSTLSPTTAITPWLTLLNPSNPERHKIDDTILYSRWQHVFPRTSDMKVQKWKTLCCPAAVPLTTEYFPAKAQFDAEYQRHPYNIDQNLDDDVVDEPKSRKDFIKELISMRFSQGFQVIVGPSVARAFGQKVIKVADVFARDQPLDDGTSVFMSVGNTIHQLSCVNGSEVEVNIYLRKPTDVTAESQRYPSAYRPAIRTIFDTEYETRSFDILTPKMDRNWNTIDSYLAGHYDQMMDSLRFWRARFVLIPLGPKHPLIQRVQTSDNPEELRIEGIKRLGQLWQKHRYVAPSDRRFQPTAKRRSPLDIVYKTEDPSVVIAAEVETLPILESLEGPHRKGGLVTRKERFQKGNLNLAALAEAMQQPVENGGVPLRNRRWHLRLHNAAFIGSDMTTWILDNFEDLDSREEAEELGNALMVPNEPKHKDKDKSKDKEKDKEKEHAEPKSEKDRGLFVHVERRHNFRDGNYFYQIAPEFAKPQPGWFSSRRRDVTSPAAPGSDGGSMDSPRPNMPRPLVPNDPKSPASLGPAIGSSQLLKNRPKVVLSKMIKYDIDPRKRSYRPERIDLHYDRLHNPDNCYHIRIGWMNTTSKLVEDTIEGWEREASQYGLRLVEVPINEACRITETNPFRKPYRIRLAIRPPLERPETYYDPNSLDLQAGPSKNFYQTVILKNFDFVLDMEAASNFPSDVDVRYSWGKPDFSYTQYIHRSGAVLAQITDEGDFLVLANRLYNKRTSMARDKELRSQVHSEQQQQQQQQQQQQPQPQPLPPLNTNTRAMAQIAPYVSGHPTTNLPESAAPLASPQVRPTFYHFSPASRPIDASIYGSKISYPAGRSEPEVLKTELEAFCLNEVALTAFYKDILDKGQRPHGTPASTATTQSIAGLEPVPEASIPSLGLGPGILGGDGAGGVGNGHSAAMVSMRMSSPMAFLRRGSVQYDGMGLGSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTS2</accession>
    <name>A0A7D5UTS2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein BRE4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BRE4</name>
        <name evidence="8" type="ORF">G6M90_00g037460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547107.1">
        <property type="nucleotide sequence ID" value="XM_014691621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTS2"/>
    <dbReference type="GeneID" id="26239670"/>
    <dbReference type="KEGG" id="mbrn:26239670"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="800"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="834"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119489" checksum="A1B123B52DF937A5" modified="2021-02-10" version="1">MSSDNQDTEAQADDDIRRRIKVQDDTPGNLEDDPPIQVSLSRPHITKHSRPRLESRRSSAMSIAQIDQVLSDHDMDEDTYGVSEVREGLFEAIFLKPLHLNVADLLERSKTTLPAQFDKSNPLAPKYFVSRQWHQLNSLCRRIATTREGIRLFKTFSAFFIAYCLCLSPGVRGWLGPYNYMMVISVILNHPARTLGGQIEGTVLTILGTAIGIGWGIIGLLLSTSTLAASAGYGGILAMFLALFMLALACIRAFFIRFYQAVLCAGIAIMFTTLADTNSQSVIWNNLRSYAVSWLFGQVIALVVNVLIFPDAGSRALATALHQAFGTMQEALDLSDQPCGMRPRRRLADAFVNLSEAYRDMRINITVSRFRPDDVEQLRNKMQAVIRALLSLQTEPELLHESRSGQGCVVIVDRRDSNNVDEQSPPSSSNIHSVVQTASDDMIRNVVEPLRAPTKDLLDSLKEDLRVCDAVLMDLSGYRKYLGPSEVVSSDLAPVQIRTKIAIAAFDTVESTILHSNDSPVSSIHDANVVQLLVFARRARETIATVEALMDQVASMQRVPDWPHAYLPSYPIWKAIHRTNAQVRHDRGGVTAGYYQKTFVEIARLLDKIKSLDYKAISQIQHGQAQEEPQAEFNRSMTNSDASIAPVSKKRKLRYKIWTGLYRLQGFESRYAFKVCLVTSLLSVPSYLPQSNEWWDYYQVWWVVVVSWAVMHPQIGGNIQDLVTRSGVAILGATWSGIGYAAGGGSPYVMGVFSALYMAPMLYRYTISSHPRSGLVGCLSFTVTSLGLQTHGGGSSPTTFAVFNGLAFFIGTAVPIIVNWVLWPFVARRELRHALSSMLFFMSILYRNVVGSYVYFSDGKEPKPEDIQRSEILEGRLREGFVRIRQLLVLTRHEIRLRAPFDPLSYSGLADACERFFDHLITVRRSAIFYNPSYIRDDPLAAQQLLSYRRDAVAAILGNLYILAGALRSKRKVPLYMPSAAAARKKLLVKTAEVEEDMSKKAPPNDIKKHKEWSDVYSFSYSESLTGCVVQLEELEKYTKLIVGEQGFDDEFQDEDEDDDNHVQNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU54</accession>
    <name>A0A7D5UU54_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g030700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986322.1">
        <property type="nucleotide sequence ID" value="XM_066130069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU54"/>
    <dbReference type="GeneID" id="90967580"/>
    <dbReference type="KEGG" id="mbrn:90967580"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI67234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="99" mass="11214" checksum="54E85BE630946E8D" modified="2021-02-10" version="1">MASVDAQQWFDKVLPRLAEEVRKVSISATNERNFQIRDISHQISMSLDMLYLSLRVKKENTTGNFQLSDKSCVAGFFHELDSIISPAVLDRLAARNVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUQ5</accession>
    <name>A0A7D5UUQ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g048220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544937.1">
        <property type="nucleotide sequence ID" value="XM_014689451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUQ5"/>
    <dbReference type="GeneID" id="26242278"/>
    <dbReference type="KEGG" id="mbrn:26242278"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="198" mass="22337" checksum="0DAB4899A9A24778" modified="2021-02-10" version="1">MFNPRFLVVSLGNPLPKYESLHSAGHFALNGLAKALRHPPFREVKFGRQTCLVSQGPKYTLVQSPTLMNISGPFVAKVWQEIVRQHDPSSTSLVIVHDELEKALGDVRLTPWDRSHRGHNGLKSVKKSLVQDKFPESPFARIAIGIGRPAERDAATVSKYVLDKITVEQRRVLEEAVPLDVAKRLVELEDEWRTEMEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV55</accession>
    <name>A0A7D5UV55_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g040390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547387.1">
        <property type="nucleotide sequence ID" value="XM_014691901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV55"/>
    <dbReference type="GeneID" id="26239950"/>
    <dbReference type="KEGG" id="mbrn:26239950"/>
    <dbReference type="OrthoDB" id="9980836at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="221" mass="25085" checksum="F9B20B4A22F4102E" modified="2021-02-10" version="1">MSPAATATTSELISTLLKTVEDRIVPLTQQGVASGSKVFGAAILSRSTLRPLTVATNNERVSPLLHGEINCIQQFFTVDYQDPTARPDPQKDCIFFATHEPCSLCLSGIAWSGFNEFYYLFTYADSRDLFSIPYDIDILESVFRVQGEETDEQVHKRALYNRANKFFRGRSVEDLLDDLQSEAEREMWRQEIQRVKDLYISLSETYQKGKESGAESSSVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVG3</accession>
    <name>A0A7D5UVG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g044080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547742.1">
        <property type="nucleotide sequence ID" value="XM_014692256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVG3"/>
    <dbReference type="GeneID" id="26240305"/>
    <dbReference type="KEGG" id="mbrn:26240305"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="79"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="547" mass="60989" checksum="BFFBEE1A8A6EDBF1" modified="2021-02-10" version="1">MNGVSWQGLAERFQRRRAAAIPTRWTIPPLKLDETIRSTTRPIDLLPRLLSYNEMQITALGAAALAAKIRNHELSCIQVTEAFCHQAAVAQQLTNCLTEIFFTEAMEQARQLDDMLKTTGRPIGPLHGVPVSIKDQINIKGQHTTAGYISFARNPARDQDAQLVEVLRNAGAIMYCKTNNPQCMMTLDTVNNIYGRTVNPWNNKIGPGGSSGGEGALLAMRGSPLGIGADLGGSIRIPAAFCGLYGFKPSAKRVSLRGSECTMSGQESVVAAAGPLAHNVEDLELFFQVNSDAKPWLKEPLLRMPWVSQSDQMRHQKLRIGVMLWDEVVMPHPYITRVIGEVAKTLKASGHEVIEFKAYDHKRAWDDILLPLYFTDGGRDIKQTLFAGNEPIFPSAKRLLDDPIVKERTHHEIWKLNLARDDYRTEYLQKWAETANSTPSGEPMDVLICPVSSVQGMPHDVKPWWGYCAQWNLLDYPSGVIPAGRVLKTDAYPADYEPVNQLDKENMNLYDNDLYYDLPVAIQVVAPTHEDERLMGAMRVIDEVVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVU1</accession>
    <name>A0A7D5UVU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein-sorting-associated protein 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ESCRT-II complex subunit VPS25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS25</name>
        <name evidence="9" type="ORF">G6M90_00g038720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547228.1">
        <property type="nucleotide sequence ID" value="XM_014691742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVU1"/>
    <dbReference type="GeneID" id="26239791"/>
    <dbReference type="KEGG" id="mbrn:26239791"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.570:FF:000003">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="197" mass="22063" checksum="034C7FF6774A644C" modified="2021-02-10" version="1">MASTSTSPAQPQPPSQPPDASFRFPREYHFPAFFTPQPNLTTHHAQLTKWSSLILSYAKHHRLFKLSLSSASDSALFSNIRINRRLVPADIRQVIDFMRKDGRAEYAGGDKARDGDVVYVYWKKPDEWAALVEAYVEDTAQKGSVLTLYELTDGEGTRGTELHGMDSEVLLKALNVLVKRGKAQIFGSEDSLGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ0</accession>
    <name>A0A7D5UVZ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptide transporter PTR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PTR2_1</name>
        <name evidence="10" type="ORF">G6M90_00g056790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544267.1">
        <property type="nucleotide sequence ID" value="XM_014688781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ0"/>
    <dbReference type="GeneID" id="26242679"/>
    <dbReference type="KEGG" id="mbrn:26242679"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="67190" checksum="1777B632526838FE" modified="2021-02-10" version="1">MAQNHEDMAAELHEEFNERVPNKGTDLTGGYIEKPSLDQKRDLAVGDTETGPTPDGEEPNEHERHTLRRIGENLPASAFMIAIVELTERFTYYGAQGLFQNYVNNAKDGSDGQKGLGMGHQAAFGLNLFFQWFCYVTPILGAIISDQYLGKYKTILIFCCIYWVGLLILWTTSLPVAIENGAGLGGFVTALVVIGLGTGGIKSNIAPLIADQYQRRTMAIKTEANGERVIIDPAITYQRIYMVFYWCINVGALSLMATPFMEKYEGFWTAFLLCFCMFNVGIAILIFRRKSYVIRPPQGQIITDAFKAIGMMITTRSLDGAKPSWRAEHGKSGKVAWDDHFVDELKRALRACKVFVFYPIFWVCYGQFSSNFVTQASQMEVHGMPNDFMQNFDPLSILIFTPILEKIVYPVLRRRGIELRPITRITIGFWLAALCMAYAAIVQKLIYSAGPCYDHPRNCPAGLSAENIKLPNHVHVAIQTPAYVFIGVSEIFISVTGLEYAYTKAPPSMKSFVQSLYLFTNAFGSAISEGFVPVAKDPKFLWMYTGIAVAAAVTGCLFYLLFHHYDAQEEAMYALDRDVPVLTLPGQEQTEKPGDKEVDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ1</accession>
    <name>A0A7D5UVZ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545135.1">
        <property type="nucleotide sequence ID" value="XM_014689649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ1"/>
    <dbReference type="GeneID" id="26242476"/>
    <dbReference type="KEGG" id="mbrn:26242476"/>
    <dbReference type="OrthoDB" id="5239281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15627" checksum="463DD4C2F662EE6B" modified="2021-02-10" version="1">MPRKAKAAATGGEGEAHTGLTDGELRFIKAVFDNMTQKPDADWDKVATDLGLKDAKCAKERFRQMSVRHGWREQQPASGNPSPRKPGKNGATGPSGDGKITKRGPRTPRKVKKEEASDAGEDDEVDLIGGGDDGGEAKAEAEADVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWE2</accession>
    <name>A0A7D5UWE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AIM18</name>
        <name evidence="3" type="ORF">G6M90_00g048180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544933.1">
        <property type="nucleotide sequence ID" value="XM_014689447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWE2"/>
    <dbReference type="GeneID" id="26242274"/>
    <dbReference type="KEGG" id="mbrn:26242274"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="387" mass="42491" checksum="8BDC56E118DC48E5" modified="2021-02-10" version="1">MRHPSRLARPLARASACPSRVPTTSRALLSQRASASARATQDFDLNKLNSKRRDYERNRTAFLTAGAVAGIISFIYTAWKLKKALDVQGEKDKIAVKCDAPIPTEAFKTEAGEKRKVVLHDEEGREIVPTGYSVVPAFPRTMELDLPGASTAAGPVAASVANSAGVEYTLVGLGMRTVTFIGIQVYLVGFYVATQDIERLQHYLVKKINPLATTLIPSEKDALRKALRDAAEGEQTWDSILREAGCRTAFRIVPVRDTDFHHLRDGFVRAIQARSGRGNAYSDEAFGAAMKEFKIFFNRGQVPKRKELLLSRDANGTLAVLYGEGGHKQQVGRSLMGTLSDERLSRLLWLNYLAGDKVASEGARDNIIEGIMEFVERPVGTVAAQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWM7</accession>
    <name>A0A7D5UWM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pnbA</name>
        <name evidence="5" type="ORF">G6M90_00g036340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547026.1">
        <property type="nucleotide sequence ID" value="XM_014691540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWM7"/>
    <dbReference type="GeneID" id="26239589"/>
    <dbReference type="KEGG" id="mbrn:26239589"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="443" mass="47849" checksum="1B44944420894B50" modified="2021-02-10" version="1">MADASKITLQLANGKITVLKNDNILVARGIPYAQAERFQPPQPMADWSSVKDFTQPGPICPQLKSRLDALNGPIAQGRAMSEDCLRVSVFAPASNPSPSLPVMVFIHGGGYSSGAGDLDCYSGAGLAKKGVVVVNITYRLGILGYQPIGGRAPANLGLMDQIAALKWVQGNIESFGGDPKRVCVFGESAGADSIYCLMGANGAEGLFQRAVMQSTPLGARLSDRREMLDALESLASELVPGDPGAASVEELLTIQGQLAMKGLSFATAGLSFGPIMNHDPLPDAETFDKRLDEAIRRVPIFIGYTKDEGTAFVPLFNNMDPLVRPAEMESSPAEYIGKAWFKTESNELYQKIKGAQPVEQPWFYEFNITPDQSPWGAAHTVDMPFLLGTWASWKDAPMMKGNGVHEVVERVGDEVKSLWVAFARGDDVGRREFVIDEGFALKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX99</accession>
    <name>A0A7D5UX99_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hsk1-interacting molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">him1</name>
        <name evidence="7" type="ORF">G6M90_00g037130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986621.1">
        <property type="nucleotide sequence ID" value="XM_066130216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX99"/>
    <dbReference type="GeneID" id="90967649"/>
    <dbReference type="KEGG" id="mbrn:90967649"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="575"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="639" mass="72527" checksum="AE1A3EA5E14B36C8" modified="2021-02-10" version="1">MSSRRVPLTSNPNVANSPLRGPGSLHAYAKQKRSYANVQREEAYGQPPPVKKQVLEDGTQRAVRSPSKAHRTQVVVQRSSTRLVAKDRATRTTQASARTVQDVDTEKEVWKKHHRAKFPKMVFYFESIPDDIRAKLTKRVNYLGARQEPFFSIDITHVVTTRSIPPEKSGTQHEESLEQEQQEPEEQPQTINPSLLDRNTAAGRRKLLFDFRQTQIPSQQADDPTRRTKGTRNNDVLHKAREMGKKIWSLDKFQNMLAVLLESETRGATYASGTTSVRSQYGVTKGSHEPNLLQLLHNERLNGPSDRDPTAVNRELVYFKGPYIYVWDMDDKYKPIMVREYAKAVNKQDGEWPQFRSVGNGRCPFVEEIEIPEKEQRRNREREKDARLVKREDPVPILKPPEIPIPKPVTGKRTLTEMEDGQNRVRTGPAMDVFNPAKAVLSKQAELKSQNAFTSRAEGTRLFAGEPVASGMQPSNVTSAIRSQMISSTSGINGGKAGTSKEVHGLQRKVLQKANPASHDVSSRRFAEVSMDVASSRSTTMSRQTSKAVQPHDDESQRTECREKKSNSQSLKSKRDLKPGYCENCQDKFPDFDEHILSRKHRKFAENDDNWTELDLLLEQLKRMPKYAGAESDNDDNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXE6</accession>
    <name>A0A7D5UXE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LYPA1</name>
        <name evidence="3" type="ORF">G6M90_00g062170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542658.1">
        <property type="nucleotide sequence ID" value="XM_014687172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXE6"/>
    <dbReference type="GeneID" id="26244607"/>
    <dbReference type="KEGG" id="mbrn:26244607"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="273" mass="29636" checksum="250CDEAE67170796" modified="2021-02-10" version="1">MAAMPVIVPAAAKHTHTVVFLHGRGDVAENFVASLEYSKSSRDQTLQEIFPSFRWVFPKAGVGASFSFGGNKVSQWFDIWNVADFSEREEMQTLGLKESVAMIRKVLHIEAGILGGHWDRIILAGISQGAATATHALLNLKLPEAADDGTKLSGGLAAFVGFSCRMPFPGRTLRETRAVLSLEDAPEDDEVIRRTPVLLEHCVDDPLVLVENGRVLRDTLRGFGAEVHSREYPDGGHWLNSPAGMDDVAEYLTHVLGLTPASAATNGTEMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXS0</accession>
    <name>A0A7D5UXS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g055920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544185.1">
        <property type="nucleotide sequence ID" value="XM_014688699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXS0"/>
    <dbReference type="GeneID" id="26242597"/>
    <dbReference type="KEGG" id="mbrn:26242597"/>
    <dbReference type="OrthoDB" id="5407957at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF4">
        <property type="entry name" value="DUF5923 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="205"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="741" mass="83611" checksum="E6030884349DAF07" modified="2021-02-10" version="1">MDCFGLCGSKDDDDERQPLLPQYNQDTTRQDRLHEKLHTYQMLRAMSNGYMPSNKQVIIHLRTLLCATILNPSEQSTLSNSGRALIRTTRLWLQQFMDLLEQKNAKDQIQDFIWYLSKARLDVDVANVRKNMSKSKARADVSATVESLRTVVSLAMLNSDFRVFVADAATIARQVLRDTALALGDVSKEVGDKLDSPGEDMEALKKTDQDAQEPPSSEYVKDQAKDVGETAYKEAAHVGEEAYTSFSEHMNAEAKDILVNRLRNAVTNLRKRTDYSESVSTLSGILQKYLKIYLSVGSDAVDTLEGNLHNNTQVENAVHNFWLFLSSFGDGESWEKARASFSDFAEHNRTDENLDEFVSQFVNLIQGMLSKPEFFDNMDERLDELRERLKELTSGSSMGEDASNLLRSIQQALQSTAEDKDVKNMTSASLRLVHILFPPGEMGNTDLVRDCVNTFIPLLVQAVQYIPIPRLEVSTPAMDLLMENLILEPGQTVNSSSFLPYNLQFSSRNDIDITKSPFGTSSSVASLVTIKLAGMSIAADDLGYWLRLHSGLLRFVDEGLTSFHLDHRGIDVTLDVEIGRERLEELVTLRSVHVKVHHLDYSLRKSKFSCIAWLLKPFIRPLLRKVLEKQISSAIDEGLRTLNRELVFARERLRATRVCNPGDLWTFIRAVAARLVPPPDPDIHTRVGVEPGKGVFRGRYAPGSLVKVWEEEARDAEQNIFEYRQDGWRNGIFDVQTTPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYJ0</accession>
    <name>A0A7D5UYJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">OTU2</name>
        <name evidence="3" type="ORF">G6M90_00g076210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545480.1">
        <property type="nucleotide sequence ID" value="XM_014689994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYJ0"/>
    <dbReference type="GeneID" id="26241513"/>
    <dbReference type="KEGG" id="mbrn:26241513"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22762">
        <property type="entry name" value="OTU_fungi_OTU2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049771">
        <property type="entry name" value="OTU2-like_OTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="171"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="309" mass="34004" checksum="19F831CE5A048E98" modified="2021-02-10" version="1">MEGESLDQMTARHRRELKDLQGRITSKKKNASKKTRKGVNDECSGMERQLREKQAAEVASLDSTPRDVEPEPDAADDDDTTTTADEANGPERAAAEADDEAIDAAVDKLRVNGDAPPAAGKRRNRQKERLARRAAEQEAAAQQASEEASGMTDHRARESEYMRRTIAVHGLVEKDIAPDGHCLFSAVADQLSQSGIPTGREDASEPAYRTVRRAAAAYMGDNGDDFAPFLEGGDLGSHLARVRDTAEWGGQLELTALARRYGAEIRVVQDGRTERIGEEEGARTGRVLWLAYYRHGYGLGEHYNSLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYQ0</accession>
    <name>A0A7D5UYQ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g063000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542582.1">
        <property type="nucleotide sequence ID" value="XM_014687096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYQ0"/>
    <dbReference type="GeneID" id="26244531"/>
    <dbReference type="KEGG" id="mbrn:26244531"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="220" mass="25390" checksum="6AAA44260A8F08B2" modified="2021-02-10" version="1">MSDSRRPRRPDSRQMWDESDRPRRPRDRDRFDRERDSDRPHPRSRSRERRGGYDDRSRSPDRRYRDRGGRGRGRGGQDRSPRDSRRYDDRERDRPNARRRSASPTSTSPPPSSTLPTRSRTDKANRAPASSHRRSPPPRDPSRDDTPMSNEDDAEPGEADADDDDMANMQAMMGFGGFGTTKGKKVVGNSAGAVRKEKKMEYRQYMNRQGGFNRPLSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYQ5</accession>
    <name>A0A7D5UYQ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Candidapepsin-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SAP10</name>
        <name evidence="3" type="ORF">G6M90_00g060930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986931.1">
        <property type="nucleotide sequence ID" value="XM_066130712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYQ5"/>
    <dbReference type="GeneID" id="90967835"/>
    <dbReference type="KEGG" id="mbrn:90967835"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="31203" checksum="EFB13322702094CF" modified="2021-02-10" version="1">MSNTQRKENQSPTHQCVLGRSLGELQFGVANLEKWPTRVGRNVGILGLRAPGPKNPYANEFIIKKMLDNKVIPDAAFSMSVDGNGKGAITFGGYDTKRFAGPLETFPFASQTSNHYVVNMKSISVSGGTNADQVIQGQGLTIGLDSGSPAVALKKALYDRVVAALGATVPQGSSVPVVNCTLMRDARLTLAMSDTLSITIPVKDFEMNIPQLKTGGNCPVAIISGNYPADVWIGGHFLRRAYVVYDSARRSIHVARVGNCGSNVVAISGGLPTGLVGECSEQPLGPIPAPDAPGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZC3</accession>
    <name>A0A7D5UZC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">sed3_0</name>
        <name evidence="18" type="ORF">G6M90_00g077550</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986950.1">
        <property type="nucleotide sequence ID" value="XM_066131073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZC3"/>
    <dbReference type="GeneID" id="26241380"/>
    <dbReference type="KEGG" id="mbrn:26241380"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF10">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028836419" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="20"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="211"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="597" mass="64970" checksum="F51B5D588CC5F20C" modified="2021-02-10" version="1">MSILSLLCVLGSIFLVVSADLVVVEHLDQPPDGWTKLGAANASQLIRLSIALESQGHDVFERTLQEVSDPTHPRYGQYLSRDEAVALVRPRPRSVAVVREWLLSENVTQGQVQERGLFVDAVMTIGTAENLLSTTYGLFQHGKQRAIGALAYSVPAEVRPHITSIQPTTFFESGNLFKKSPRMSGVGIATARRRNPGVRARSTGLQDCENYNTPECLRGLYKMSNDYTKPHRSSLLGVAGFHGQAAQYDELEKYLDTYAPYAKGANFSVELINNGTNPQGEYPGFEANMDIQIAVSMAFRVPVRFYSTGGEGHEFIPDLDVYDPEKQHLEPWLQFASYLLDLPDRDLPQVMSISYGGNEQAVPKPYARRICQMFGLLTLRGVSIILASGDQGPGVSCQSNDGTNSTKFLPAFPSGCPYLTVVGATERNAPERAINFSSGGFSEYWPRPAWQEAAVSRYLDAHGDKWKGYYNRAGRGFPDVSAQGIGYPFFNHGGNASGGGTSASAPLFASMIAVINDSRMKRGKPPLGFLNPWLYLGASRAFTDITHGRSDGCKGTSFSGAKAPVIPGAGWDAVEGWDPVTGLGTPLFDELQELAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZI0</accession>
    <name>A0A7D5UZI0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987080.1">
        <property type="nucleotide sequence ID" value="XM_066130913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZI0"/>
    <dbReference type="GeneID" id="90967919"/>
    <dbReference type="KEGG" id="mbrn:90967919"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="80" mass="9009" checksum="A906CCEFC64E3667" modified="2021-02-10" version="1">MPEVHCEVKLITIMFKSYDPGLQRLPKSKKVSIPKTYSKGFVPQENLEQNEAVTEMSEDHGMTGDDAVGVTIRIEDINML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZW6</accession>
    <name>A0A7D5UZW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine transporter thi9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thi9</name>
        <name evidence="8" type="ORF">G6M90_00g067820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987165.1">
        <property type="nucleotide sequence ID" value="XM_066130859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZW6"/>
    <dbReference type="GeneID" id="26246646"/>
    <dbReference type="KEGG" id="mbrn:26246646"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF13">
        <property type="entry name" value="THIAMINE TRANSPORTER THI9"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="386"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI71075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="557" mass="60469" checksum="93E955318478827F" modified="2021-02-10" version="1">MAAEGIQARHAHAGTVNNSCDPEQEMTADSRILESLGYKPVLHRTFNLFHNFATTFAALYFIGGVRVTFSTGIAAGGNLAYWYSHQPSYKNVSNGINRTSFIVTCVFTFITAAVIAEICSSLPLAGSIYLWAAEAGGPRFGRLFGFVVAWWSTTAWTTFCASNTQSAVNYMLSEIVVFNLDFPSDASSVKFRAVQWVATEILLALAAIWNLLPPRYFKWIFYLSTSSVIVDFVLNMVWLPIATSKTYGFRSAHDAFMTTYNGTGAPAGWNWCLSYLATAGILIGFDASGHVAEETRNASMSAARGIFWSTVVSGVGGFVVVILFLFCVPSSDVFFSFGGAQPFVPLYAAILGDGGHILMNIVCIVALWFNTAIAVLAASRLVFAVARDGVLPFSPWVSQVVDGQPRNAVIVVWAVASIITCTILPSSVAFTSLVSAAGVPSAAAYGLICIGRLFLTPNNFPRAAWSLGRLSKPFQAIAILWNGWVVAVLYSPYTFPVSAATFNYAPVIMGIVTIFALLSWWFIPAERWLPSERIQQTLDAKTPGSQQSFSEDHINPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V056</accession>
    <name>A0A7D5V056_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pierisin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g067160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130846.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26247665"/>
    <dbReference type="KEGG" id="mbrn:26247665"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054695">
        <property type="entry name" value="Pierisin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22596">
        <property type="entry name" value="Scabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028854378" description="Pierisin-like domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Pierisin-like" evidence="3">
        <location>
            <begin position="103"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="907" mass="98793" checksum="E901EBC49318A2DE" modified="2021-02-10" version="1">MKAYRLVALFAWEQVVAASRAPDLLSSLPKSNAAIAGPATSLAVVGNTAFHHIIPNHSNLATKHGAASSRDMIKRQPTNPPKISAEEASTKSVPGGGKSGVFYRGDSRSPAEIFKTGFAPQGADKSLQNHLSFVGGSGLVSLSRSRKSAESYAFGRSAENNQKGYIYVMAPKDIPNGYWVPEIYPPNKNPAVGANQEFAVDGSVPPSSISYAYEVTREKPSSKSNKIRNNDYSLKSSLPCSTKKRAICDATRYSAKPYKSSKIRITKAVGKAAAITLLAPHARRLLEAIKQWDNPIGAAVNWLDNKIADLQELIGGPQRDDIDGNDLKAKLICALKGGQAKEIIAGRPNNICKPSSEKYADNLRRDFESGKLDRVIEMCKGISVYPGGHPAVWEWTKGYCAALHRTSEYAARMWELAVSGLLNSCSELEDNPPENEDLYDRLEEHCSKFQAEVDRAENPVAKPVASSVTVMKCKCGTKLPAFFFLCGRICRATLFQQRAKSSPAVKPAAKPAAKPAAKPAAKPQAKPPAKPAKPLPELTVGNCKCDALKLPQIFLPCGRLCRASIIQQRKPSSTAKPAKPATKPAPKPASKPASKPVAKPAVQFTAERCQLVFVPMDEPRVVTWKHHTGGQLAFFLTRGPESFLSGAAHQLFVDSRINMAMLAIGTRARSPFSSHEWKTIPWGINPKSAKDRLVDIMLEIPTLLEQIAQLQSRSCPTAAGIVQEKVLSRCVQLEGAMRVWAAKMGTDILRFDYTFMGDCVPVPQKEAEFGLLHLSIVYWFIEMMLVSVKMFVSELCAMETAEAMRQLQMAARKSARALSLLFASSGGLARRISGLLALSIALRYFLIVEAPGGISDESCMLQSLLDRDLNGSTIRTLLTRMRGGQDPLLVGTDYAGSHWPENVLHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V064</accession>
    <name>A0A7D5V064_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fluconazole resistance protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FCR3</name>
        <name evidence="7" type="ORF">G6M90_00g092190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. YAP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541863.2">
        <property type="nucleotide sequence ID" value="XM_014686377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V064"/>
    <dbReference type="GeneID" id="26245331"/>
    <dbReference type="KEGG" id="mbrn:26245331"/>
    <dbReference type="OrthoDB" id="4940293at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="245"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="429" mass="46429" checksum="A330DEFAB6558E8F" modified="2021-02-10" version="1">MPSGLTPPFHLRHALTGDQSTFSPPSPVASSSHAQRPCFDFLAAFLRFPALSISSLYLASSQSQSPSPTSPTRLSCIPSPSQFPSVSFCQHSVNGSTVTESEPQSHRTAMDFSSQPFPFTAGQPYQSFMSVPPLTPSNSHSAGSDDYNTASPADGFDGIPNTDQFQGFEYNQGFHNPSQHQTPGFPGPPTPPNPATYTSQQSISQLHQAASSNGPLNSTLSGARSDGADDNSHTRGGSDDDDSLTPAQSRRKAQNRAAQRAFRERKEKHVKDLEAKLAHMEAAQQQASVENERLKRDLQKVSTENEILRATSSVTNGHHISHSPEPTTTGPMRYNPTDFYSNVLQNHKNKSPSHRIVTSDDGERLLAAGAAWDFIIDHDLYKRGLVDVGDVSERLKSCALCDGQGPVFSERSIVYAMEQSVASGSDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V065</accession>
    <name>A0A7D5V065_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cdc10</name>
        <name evidence="11" type="ORF">G6M90_00g074020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545663.1">
        <property type="nucleotide sequence ID" value="XM_014690177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V065"/>
    <dbReference type="GeneID" id="26241696"/>
    <dbReference type="KEGG" id="mbrn:26241696"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="806" mass="87812" checksum="8D75E2C830F9CF2E" modified="2021-02-10" version="1">MPSASQSSQQSFSMSQQSQPRHSASFHQSYNGADGPQIYSASYSGVDVYEMEVNNVAVMRRRNDSWLNATQILKVAGVDKGKRTKILEKEIQTGEHEKVQGGYGKYQGTWIKFERGVEVCRQYGVEEILRPLLTYDMGQDGGVAGRGDFNTPTKEQAMAAQRKRLYNSGVDARPNGMSGTFFKNISSTASHAVAAISKARFDSPGPRSRNGPARAPSFSRQPSMQNGDEFPGNSQQSYTSDYSQQLDSAYSTQQAAALAGMPEHEPPRKRQRVTMTPVDSFSGYNQSMDMYGTAFPGSPTEPNESFMYTQSAIQDGVAAGDDGNGSLPPLPYEMSPDVEMKRNTLMGLFMDSSPNDTSKHELLRTFSPAELDMPIDPQSHTALHWAATLARMPLLRALIAAGASPYRVNASGETALMRACLVTNSMDQGSFPDLLEVLGGTVESRDHKGRTVLHHIAVTSAVKGRNAASRYYLESLLEWVVRQGSVPSSQANSSVPNSSQSVIPKMGIARFMSEIVNAQDSSGDTALNIAARIGNRSIISQLLEVGGDPNIANRVGLRPLDFGIGGDNAEEKTNSEIPADKNGGAGSSQRTRESSDEIIASITHLLGETGTAFQQEMKSKQVSLDAMHATLRTTSTQLGDARRNLEQLTSTVKKQQLARQKVSNLAHAREDEQLRLMNEQQRSSQPNPSASWETELSAMLEAAEESTNSGGFGSESMLPTASILRSRIRAMEARREVTRKMVSALKGRSRDVEIKYRRVVALCTGVQEGEVDAVVDNLLKAVESERDELDIGRVRRFLGGVEGVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V070</accession>
    <name>A0A7D5V070_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DCG1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g079870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539537.1">
        <property type="nucleotide sequence ID" value="XM_014684051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V070"/>
    <dbReference type="GeneID" id="26247701"/>
    <dbReference type="KEGG" id="mbrn:26247701"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26959" checksum="029842F657609770" modified="2021-02-10" version="1">MDSESPPQMRILLLNPNSSEAMTRGMVQAAKSTPVSNSVEIHSMTASSRAPPSIDNSEDIQASTKVVLSELPAADAARNNWDAILVACFSVHTLVPELSNWFDGPVTGIFEASILTAMSLLRPGEQWGIVTTGKFWEKHLSDGVYEFLGVDAAGRSTKFAGVASSGLTAGDFHTVPPEEVKTKLSLATKGLLESGNIACVVMGCGGMAGLEDIIRSTAKDVYGEKRAGELYIVDGVKTGIMQLHQSINAAKTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V072</accession>
    <name>A0A7D5V072_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">not3</name>
        <name evidence="15" type="ORF">G6M90_00g077880</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987185.1">
        <property type="nucleotide sequence ID" value="XM_066131078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V072"/>
    <dbReference type="GeneID" id="26241350"/>
    <dbReference type="KEGG" id="mbrn:26241350"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
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    </dbReference>
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        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="484"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI71175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="615" mass="68392" checksum="66A0EE72516A6C69" modified="2021-02-10" version="1">MAARKLQQEVDKCFKKVAEGVAEFEAIYDKIEQSNNPAQKEKLEDNLKREIKKLQRLRDQIKTWAASNDIKDKAPLLEHRKLIETQMEKFKAVEKAMKTKAYSKEGLSAAAKLDPKEQAKVEAGEFLSNMVDDLEQQIESLEAESESIQATMKKGKGQSAKAERMAEIDRVIERHKWHQGKLELIRRSLENGAVETEQVNEMEENIRYYVSDNMNDDFMEDEGIYDELDLEDEEGTYGMVQENEKSSSQDAQSVQDEIMPEPELSSKPSRKAPKEIEASARKASSQTRSPLPALATLHTPLSSTSTGGVANPSMKPAAAPARPAGEGLKYASAAAAAAASDKGNVGIAPLPPPPGSSMGISPLPPVQPRTSATNSPAIAPAQPATGSESKAPAPPAEPEISIMTRPSKKKGTGKQPAVAQHAEGSTVQTNGATNGIKPIVEEPEESIYHLPSSLQDLVDSYEASKKRPLHPSAQSTLRLMAASQAALPDVVDADVPRNYRPDVPMPQTGSGFPREPLPIFDDPRLYGRIDPDTLFYVFYYKQGTAQQYLAAKALKDQSWRFHKQYQTWFQRHEEPKNITEEFEQGTYRFFDYESTWMNRRKADFKFAYKFLEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0N7</accession>
    <name>A0A7D5V0N7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KXD1</name>
        <name evidence="10" type="ORF">G6M90_00g071700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545889.1">
        <property type="nucleotide sequence ID" value="XM_014690403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0N7"/>
    <dbReference type="GeneID" id="26241922"/>
    <dbReference type="KEGG" id="mbrn:26241922"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="181" mass="20296" checksum="50BAF4428403F5A4" modified="2021-02-10" version="1">MSGPFPTVSYAMPMAVPGKGNQYPTYTHYSMSPPECDDDMSSASGVPSYGNSGYTGSASYMGSNDYDSANSASGIDFQEYMQERFANSFNPIPLDRSMAVQAQTSGKLNAKHRELMDLQKQAQARLAKTRERFQDGMRDAREVRGDLEWTQKKVSSLQAKASRKHPKEYRKARERHPSPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0R0</accession>
    <name>A0A7D5V0R0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain Tctex-type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g075730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545526.1">
        <property type="nucleotide sequence ID" value="XM_014690040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0R0"/>
    <dbReference type="GeneID" id="26241559"/>
    <dbReference type="KEGG" id="mbrn:26241559"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16948" checksum="D0DE87C2F30E3909" modified="2021-02-10" version="1">MSTPPIPFNRLKQIATDVCNNAIGSAEFYDHAKTEQWNSTIINSMLKAVISESTPQGASAPSFKFACNSTIVQHLVPTSSLNKARGGTETKEEKPHISTSSEATATDGKPHVGRRGMHSATGAYWDEKKDGMWTFKYDGGEGKGMDVVIMLIWIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V184</accession>
    <name>A0A7D5V184_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Satratoxin biosynthesis SC1 cluster transcription factor SAT9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SAT9</name>
        <name evidence="6" type="ORF">G6M90_00g085150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541073.2">
        <property type="nucleotide sequence ID" value="XM_014685587.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V184"/>
    <dbReference type="GeneID" id="26246062"/>
    <dbReference type="KEGG" id="mbrn:26246062"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="438" mass="48366" checksum="8623CC4F390A3448" modified="2021-02-10" version="1">MLRRHKSIEIVLAFMVNIPWMFPGQHSTDDEACVYISMATSVAIDLSLHKVIVPTDVLQEGSKLALARGECLDTRTALAMDGYPDLDPWTDKAKLLLRNRERCWISLFVLERGMSLARGRPFVVPVTKLIKDCDSWYRSAVGDPQDGHLVSMAVLRRDLDGLFATVRSLCDGSQNPVSDGSLIAQSIQSSIERFFDQWYTEWGVSIGTGPQRRLPPYVDILVTHTRLSTYGGVINHPTAPIEVRQFFRTAGLSSALNVMRAAIQGEGQLHSMPNNTAIMISFAACFALTLSAYTSGGSTLVPSIRKLIDEAAGVLERIGTITQHRNGLSTLYGRYLRQIVRKAAKQNVAYPSAPPQNTSNPGAPQIQPIGAPVATSNSNSFLTQQLTWPEPLQFSAMSDDQITHVLNQPGNEFEASFGGLSWEDMSNFDWLHWPEFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1J6</accession>
    <name>A0A7D5V1J6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fluG_0</name>
        <name evidence="5" type="ORF">G6M90_00g083910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543608.1">
        <property type="nucleotide sequence ID" value="XM_014688122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1J6"/>
    <dbReference type="GeneID" id="26243785"/>
    <dbReference type="KEGG" id="mbrn:26243785"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="537"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="862" mass="95792" checksum="C945A47B60F41F3D" modified="2021-02-10" version="1">MDQGFQAGAEALRRSILSTPIIDNHAHPLLKSSHIAKYPLLTIVTEAHGDALDSSRTSLAHIRAVKQLSEQLGCAATWDAVEAAIAKERRHDYAEWTRKCLSGIECILVDDGLDHEQAVEPYSYFDQFAPSPSKRILRIEQVAAKFIEFACISQTSAARAFDYAIADFEAELRGAISNPDIVGFKSVICYRTGLDIASGASESEARVAFASIFSQRQSANATRFTRLNHRALNEFIVHRLAQLIQDSKSVHKKPIQFHTGLGDNDLTLTRSSPAHLQEFARQYPTVPIVLLHSGYPFDREAGYMAAMYENVYADIGEVFPFVNRDGQESIVRHILELCPWEKIIWSTDGHWFPETFYLAIVQMREVFHTVLCKLVQKGDITWKQATHMVQDMLFNTSNKIYNLGLTLRSQLPESVPSSGATSATVESQHLLTYLSNAEKPHYIRLCWVDYTGIPRMRVIPSRQVLSTLKNNQPLSATVTKGCLGVLQNDVLIPGVGAIGEFRLQPDFSSLHHGPRDGHITIMCDFKEKDGSLVNLCPRTMLKRALGLARLQDIELWFGFEIELVLLRRSGNGGYSDHSNDGHAWSTVGAMDHEVVEKVLEPAIQQLDHAGVYVEMLHAESAKGQFEIILPKARAMEAVDTLIFARQVIASCASACGYKMTLHPKPIANACGTAAHAHISIASDDLNAGLYESFYAGVLSHLRAICAFTCSNMVSYERLRNGVWAGGTWVAWGTQNREAPLRKIENSHWELKCVDGLSNPYIATAVVVLAGLDGVQKGKGLTWRDCTTDPALLSSDERLQLGIEKKLPGSIEDALNALSEDEDLTNLLGADVVERYVAVKEAEVDLMRSMSTEDRRKWIIDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1N1</accession>
    <name>A0A7D5V1N1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g086720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987455.1">
        <property type="nucleotide sequence ID" value="XM_066131294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1N1"/>
    <dbReference type="GeneID" id="90968088"/>
    <dbReference type="KEGG" id="mbrn:90968088"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="223" mass="26172" checksum="B3B794D91D0A979C" modified="2021-02-10" version="1">MSQESCWAIYQALICLAGNPCDGQFTRQQRLTETAATTATGQIQAALPHYYDSPNGREYLTELPSQDNYVHSRRQLRPTEPTREEWDEIFKEYFWLKAAILLRQAQNHMRRPEFGYYMKTSIPVDRMMILQTFQYYILVCLGRGEIADPWLQIKADYVDTKVPDLNMIRMEWENARGNYSSIILLDSFWLAQSLDVQRTVTKGRYMRWVIGVLYQRSLLVSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1N3</accession>
    <name>A0A7D5V1N3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">TIF6</name>
        <name evidence="7" type="ORF">G6M90_00g087930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542322.1">
        <property type="nucleotide sequence ID" value="XM_014686836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1N3"/>
    <dbReference type="GeneID" id="26244836"/>
    <dbReference type="KEGG" id="mbrn:26244836"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="6">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="246" mass="26534" checksum="2FB2EC6B78AC4FD7" modified="2021-02-10" version="1">MAVRAQFENSNEVGVFSTLTNSYALVALGASENFYSIFEAELQDVVPTVRTTIAGTRIIGRLTAGNRKGLLVPTSTTDQELQHLRNSLPDSVRIQRIEERLSALGNVIATNDHIALVHPDLERETEEIIADVLGVEVFRQTVADNVLVGSYMSLSNQGGLVHPKTSIQDQDELSSLLQVPLVAGSVNRGSNVVGAGMVVNDWLAVTGLDTTATELSVIESVFRLGEGMGPSNINTSMKDTMVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2S5</accession>
    <name>A0A7D5V2S5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g099960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546353.1">
        <property type="nucleotide sequence ID" value="XM_014690867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2S5"/>
    <dbReference type="GeneID" id="26240776"/>
    <dbReference type="KEGG" id="mbrn:26240776"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="193" mass="21005" checksum="B5BD9890FF594C80" modified="2021-02-10" version="1">MLCTRCIRAAAARQRLPLLRQFSASAQSRAAEPKLSTPVTDAGALAKESSIPRSICTEGTILAGLNYNKGGQDPVAKKDEEYPGWLWSCLDVMKNGADAADENAGDEFSKSKKQRKLAAKRQKALEAKLLAEGNLAALTPKIPIQHQSINLPGEEGGSVSDNIAAAEKREELRRAMRKERKAKIKEANYLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2V3</accession>
    <name>A0A7D5V2V3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g105770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541564.2">
        <property type="nucleotide sequence ID" value="XM_014686078.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2V3"/>
    <dbReference type="GeneID" id="26245814"/>
    <dbReference type="KEGG" id="mbrn:26245814"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="25649" checksum="A079A1F2C446FA30" modified="2021-02-10" version="1">MPYTQQDLFFYNGDGIGSEDLTDYKLCGLHPIILGDILPKADTCVNEEAKQPRYRIAQKLGFGAFSTVWLARDLLEEELPGAAPPTVRPPEVYMYSLSGGRIGSVWSREADIWAIGSIAYQIKTGCQLFLVQGDLQYQLYQALRLGGAPPEDWSEFWDLEKFCESTKGRRKPVLPVFNKDEAWKSRRPRNDPESEVFLDFIRKMVITEPERRSQIAELLGHPFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3T2</accession>
    <name>A0A7D5V3T2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g101880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546157.1">
        <property type="nucleotide sequence ID" value="XM_014690671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3T2"/>
    <dbReference type="GeneID" id="26240580"/>
    <dbReference type="KEGG" id="mbrn:26240580"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14000" checksum="D363B39137F18FD0" modified="2021-02-10" version="1">MLSQLSRATRATSAVRAVARVTRGNAVQARGFIAPTVSRKADFVQDLYLKEIRAYKTPAVKESDADGQVQAFAMPKTPASPEESDLASNLKEYESMAVEIEGQDAAQTSQSGSAALPDWLEAEEEDEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3W2</accession>
    <name>A0A7D5V3W2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nonribosomal peptide synthetase fmqA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fmqA</name>
        <name evidence="5" type="ORF">G6M90_00g112080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987949.1">
        <property type="nucleotide sequence ID" value="XM_066131846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3W2"/>
    <dbReference type="GeneID" id="26246874"/>
    <dbReference type="KEGG" id="mbrn:26246874"/>
    <dbReference type="OrthoDB" id="4937939at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028956833" evidence="3">
        <location>
            <begin position="17"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="4">
        <location>
            <begin position="387"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="640" mass="70492" checksum="56B5591F81B2EA83" modified="2021-02-10" version="1">MLSGTVGLSLLAASIAIDMNPVMGMMTSPPTLWSRIQGIRSRVKTCLKLASLPSEEGFFQPMSGSYGRPGCSLCWTARPSFTYRVDLSYEYADQGLVHTSSALEPEPAAWGDNTKAARFYRTGDLGRYNPDGTISYLGRKDSQVKIRGQRFELGDAENVISSSPEVRDMSLSTKIHRGRNELVAVISLADAQLPRGDGLRHLPSAYTRVVARHLQSIREFVRLRLPSHMVPSIWLAVEKVAQSVSGKVDRHCMDNWFKAKDVSMAKAAMEEQADRELNPPVTVEEKLVQYVWASVLDIQETTTSWLLRNQTLQSAVEAALLANIEGDEAAPVATRIPRDTSLGGLHDRLSRLSLSNPQFKHENIESIAPATDTQALFLIIGPPGVEGETGYHTSFTLDSTPALDAAKLRSVCGQVIQHHAILRTAFVQHRHMLYQVVFKTPTSETITIEGGGSPATPAFFGKGSNLARFYLFSREELCNSIRLNIHLALYDAASFDLLLPGLDAAYNNGQLRRGGPRYNPRISHLEALDGTAPRQFWIEMLRGCSMMHLTTPRIMPAQGYHLRDCSRLSVPLRNLQNSLGTPSTTLKAAWALVLPAALDTSDVLFGEISANRYLTMPGIDQVCGPCINFVPVRAITRHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V436</accession>
    <name>A0A7D5V436_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">orc1</name>
        <name evidence="13" type="ORF">G6M90_00g109670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543889.1">
        <property type="nucleotide sequence ID" value="XM_014688403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V436"/>
    <dbReference type="GeneID" id="26243276"/>
    <dbReference type="KEGG" id="mbrn:26243276"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="78"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI74390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="745" mass="83045" checksum="5C640AAC6EF50CD3" modified="2021-02-10" version="1">MAPHNLTRRGPEPAVRRRKTLPGISREDSDDELGSDDLPWEWIYNVEDPERANHDAQNDRKRRKVMGTKIVGARMGTFECRIGDTVLLKADGSNEAWVGIICEFVEDDGEGDNAANFMWFSTEKEIRNKDKKRNDFYWVCLLPIRSRLSKEEYTNRTDKNELYISPSWDINPLASINGKAKVMSLEAFLSKYPSGKIPRQSKDYGKTFVCRRGCNTRTATYTEEFIWEEMYSSVDDMFKLIDFVEKNTKAARGRRKAREQSPQDTAYLPPQTPTKGSRTTITTPQSKRSHAEPGSRSQKRGTGKKLEFTPLAMRKLSPSAVQSSPFQIARSRLHVSSVPTSLPCREGEFSLVYSHLEAAITDGSGNCIYISGTPGTGKTATVREVISRLEDAVGSDELDDFIFVEINGMKITDPHQSYTLLWEALRGQRASPSQALDLLEREFNNPSPRRVPCVVLMDELDQLVTKNQAVMYNFFNWPTLRHSRLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYTHEQLMKIIQSRLEGVPGNVVDADAVQFASRKVAAVSGDARRALDICRRAVEIAEGDAQGDPMTPSKNGTQDLTRRGKVTIATIKKAINEATTNPVQQHLRGLPLMSKLVMAAVLFRIRRTGLAESTFGEILDELQRATAHSSPALPGMAQILDSGLQGTPGATHRHRGRPSYVHTAALDLAAAGLINIEAHRAERSTKLRLTIADDEVKMALRDDGDLRAMGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V473</accession>
    <name>A0A7D5V473_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NOP12</name>
        <name evidence="10" type="ORF">G6M90_00g102580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987695.1">
        <property type="nucleotide sequence ID" value="XM_066131602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V473"/>
    <dbReference type="GeneID" id="26240513"/>
    <dbReference type="KEGG" id="mbrn:26240513"/>
    <dbReference type="OrthoDB" id="442677at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4B7</accession>
    <name>A0A7D5V4B7_9HYPO</name>
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        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Metarhizium brunneum</name>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_014690498.1"/>
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        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4D4</accession>
    <name>A0A7D5V4D4_9HYPO</name>
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        <submittedName>
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        <name evidence="13" type="primary">ZFP92</name>
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            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 41"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <end position="188"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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    </feature>
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        <location>
            <begin position="533"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI74138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="604" mass="64010" checksum="4598C837D3FDAABD" modified="2021-02-10" version="1">MASNVASLATEGPPPGHQNSVSATTAPSDDIVRLTKRQRESESVSPRSRAAQLSKPPGSPSKVARLSLATTIRPAEPLTGAAALEDERRRRVEEQAHSSSISPDPARSVLESLMSGVAQAMSRPSDTIQLAPTANMEPATKATTELSMATGNAARMDDHDRDEGSPPANANANSNNVPSAPVAESPAPMDLDSKKNDQVQGHQLMSPDERPQSGSMSYPGPLQTAANLSEPLNRGMSFPMPSQIQSSPTSSGGKKHKCPYCSTEFTRHHNLKSHLLTHSQEKPYLCTECQMRFRRLHDLKRHGKLHTGEKPHICPKCDRKFARGDALARHSKGAGGCAGRRASMGSFADGDELDGTIGEGDDSTMSGVAYDSVEDEELRRQSLPSMGVQHSSGDNYGAHSRTYPPAGPRPSASGLYPPNVNLSQAGTISSTSVPDSMASSHTANTSVSSIPGGPGGSGMYSQAGMTESPKPLSPGLPSHDSANLARQRSPTMTQQYQQQQVGRPPSDLQSPHSSGQARPKLPGLSHPGFVAPNSGTYSHGRTPSGAQPSGDSGNMFAQSDPSVWEYIRLLEDKIKSLSDKVVSLDQEVASLRKQLDTREGASTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6I5</accession>
    <name>A0A7D5V6I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rqh1</name>
        <name evidence="15" type="ORF">G6M90_00g101170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546228.1">
        <property type="nucleotide sequence ID" value="XM_014690742.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240651"/>
    <dbReference type="KEGG" id="mbrn:26240651"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="846"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1058"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="214"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="767"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1581"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="729"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1358"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1426"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1597"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1612"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1659"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1688"/>
            <end position="1697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI73912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1697" mass="187678" checksum="63A8EA0F7752B733" modified="2021-02-10" version="1">MTRNNLADQLSWLLSNAALSKPRLRTFPCAGDSSSLNTSQPSSIETGAAHRLRSSSSIGSQTNPRPRSRALDNAVNLNGWGEDFVDTPQVTVSDDSMVRLASTTKSKRPTLISQPQKHLPTSSATDNPGSKARPAPTGNNAVSNTPKSTRKHSPQKRSNSREFMSPNPSLDLADFDADDLECMDLTKDFTGVTASTEKSDDVQIWDTTSALWSPLPRSSKKRKSNGISRADTAEKESFPDVYDILGTEPPVSTPGSRSAIRRAGLTSTSKSRRKRDVKETPKDVPGDFGSDTLNEVMASLSSPSRHAADRRNQSSLSKSPTKKSSFPQQEDSTKKRKVNPYEGILPQDGLKRYGLSTDAMEMDDCVPDSDEEFLTPPSHNTSAITQPKQSDSSGDTNFVQNVISRSQESASWSLLNSPSTRAIDQNRADCTGITSSFSTDNSRIDVLDLVPEKSIPLDQAPKVLEYISTNSEALTKRREAIVEAIQRNGGEFVKAINERWPKEKRSQVKAEKERLLRQQKAAEELGNSMQPYREICEKREALAQLVARSYAEGNDTDDDETRLDALTDVVQEQEEGLAKLVIQAGFDESNLPMLAPPPSLSPKRGNTVVFGTQPLNMGMVDVSHGPRDSSAHATTLTQIVHQTQLPDIPTPRSRRTATQSVPGNSNKALVSKDGEGAAGELFPRETLPSTVDTRTRRVRIAPTATEDMEDDMFSEFDEADLRPVHTARSRGTPSQVPHNFASGRTQDNFSDFSDDDDILAFAEDYETRQSLGDDGSSSRRVFSETSGNVMPPPKSKGPAKRPSAPVLPELRIPPELMKHPWSPEVQKMLKDRFRMKGFRQNQLEAINATLGGKDAFVLMPTGGGKSLCYQLPAIVRTGKTRGVTIVVSPLLSLMQDQVDHMKGLGIQAVAFNGGCSAEYKRQIMSTFDEPSPEHFIELLYVTPEMVSMNAAFNNAMQTLYQRGKFARLVIDEAHCVSQWGHDFRPDYKTIGQVRMRFPRVPFMALTATATQNVIVDIKHNLNMANCQVFSQSFNRPNLYYEVRTKKSHANATESIASLINAKYHNTTGIVYTLSRKQAEEVAQTLAGYGIAARHYHAAIDPQAKVDVQRSWQKGDIKVVVATIAFGMGIDKPDVRFVMHHGLPKSLEGYYQETGRAGRDGKPSDCILFYGKADIRVLKKMIADGDGNNAQKERQMVMLNRVTAFCDNKSDCRRTEVLRYFGEDFVPSQCQKSCDNCRAGLVFEQQDFSEYAIAAIQVVHTQRRLTASQCADILLGKKSPAHEELVSDGQYGIAKGLKKHEVVRVIDRLSAEKAFHENNVVGNYGVAIQYLEVGSTAHLFLTGQRKLMLTIQVDDGNRSRTKSSAKRTTKKKGKEQDIQAMQSTYVSSPVERRKRRRKVEGSDDEENFPTTSNGYANDGFVVSDNDMREDDDEEEEAFEPLPKHRLAKAPAKPAGKKKAVPSGPPITSNKRVEDLPEIHQDLVGTFVTEARKVEEHIRNKKELRRPLFTERDLQEMAIHWTISLDRMSRIPGIDVDKVQEHGRKLLPILKRHHNMYREIMDAETPNDDDQQVVDLVSSDLEPDQAEEDVDSHYFQPKSRPEVEAFHSKLQDLSSQRQSQPKPKSSYSRGSGGGKKYFAGKKGPRKASGGGVPKRKGNSFGGRKASGSSTARSTAGTSTGKRDGKLVKKSGGGIGLMPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMS9</accession>
    <name>A0A7D5YMS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannan endo-1,6-alpha-mannosidase DFG5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DFG5_0</name>
        <name evidence="2" type="ORF">G6M90_00g022500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548304.1">
        <property type="nucleotide sequence ID" value="XM_014692818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMS9"/>
    <dbReference type="GeneID" id="26237748"/>
    <dbReference type="KEGG" id="mbrn:26237748"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028966691" evidence="1">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="396" mass="43231" checksum="7FF7630CB71CB977" modified="2021-02-10" version="1">MIPNYAYRVSLLAMMAHAVGAEEAANAQKYTNYAVSGIKSLNDHWYNVKTGIWDDAWWNSGNALTTLADFAALRLAEANKLNVGGYMRNTFVQAQKVNVKTAKFVNKAGMVSSVYCLDGSSGCMAKREFLGKRGFDDFINDFYDDEGWWALGWIRAYDVSGDDDYLGAAIDLFNDMQTGLGGPCDGGIYWSKDRQYVNAIANELYLSVAASLARRVPQNGTYKAIAVQQWDWFERSGMINAQNLINDGLDASCKNNGLQTWTYNQGVVLGGLAELFRATGDLKYAEKAVSIAQAAMKALSVDGILTETGGCDAAGDCGRDGAQFKGVFIRNLRYLNDVAPHQEFKDFIIQNAKSIWAKDRTSDNQFGVAWAGPYYPAFGATQSSALDALVAAVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNL1</accession>
    <name>A0A7D5YNL1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g009620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985815.1">
        <property type="nucleotide sequence ID" value="XM_066129671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNL1"/>
    <dbReference type="GeneID" id="26238996"/>
    <dbReference type="KEGG" id="mbrn:26238996"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF29">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI64681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="35778" checksum="00F74672B604D557" modified="2021-02-10" version="1">MSQAALTGAGSTSAANRPAKCLSRDLCVHRHSVPIKHQSAPEDLESAVARLIEVRGLFWENWKSYRELAWMKDAPLPVSGGPRDQSSGWAATLVGSLDTLWIMGLRDEFDEAAEAVCRIDIDIPGAWPMGISMRDEDVVGGDGFIPGAGEDSLFEHLPKMHELLRGGEDKYQAMARAFLDTVPWEHRFQCPWQEALWDHKRRRAEAASPRGIHRRQGPVIYPATRGHRERLLPVQNHGRQGLPNTAWDMFTTIDNEDQLCKCSRTVTAQLITNPTTPLQSFWLAKTLKYFYLVFSTPDVISLDEDVLNTEAHHFRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRM2</accession>
    <name>A0A7D5YRM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Syntaxin-like protein psy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">psy1_1</name>
        <name evidence="7" type="ORF">G6M90_00g058150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544392.1">
        <property type="nucleotide sequence ID" value="XM_014688906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRM2"/>
    <dbReference type="GeneID" id="26242804"/>
    <dbReference type="KEGG" id="mbrn:26242804"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="379" mass="43063" checksum="C334213DBE164AD2" modified="2021-02-10" version="1">MERQNGYGGRQNNYQQLGNTSDYYQGQQPREFVQNQSYRPDRGQNSNYQGSNFEMASLPQTAGRGGGKLSNEDLQEIRAIEDELKKATAKFDDLGRLQNRYLNEVNVADARNTKDRLDFLTSEITGQFDDLRRRVQQLRARTQQDGTFPPIVDTTRNSVTKALNTFSAMKQAHRKQYLAKVAREYNLAGQDASEEAIEAAIAEGADRQVFAQAMMQSNRTEHAQNALNNMRNRHQELENIERTLEQIAEMYQDMYSMVEQQDEVVMKIEEQTEVVNDNLDKGVGEINTAVKTARATRKKKWWCLGICVAIIIIIVIIVLIYIFVIRGTSGGNKNSKRELEDLTTTAVSSLRSIAVPHTRRFVPRAIVDNGSRQGTNPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTC9</accession>
    <name>A0A7D5YTC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g066590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539316.1">
        <property type="nucleotide sequence ID" value="XM_014683830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTC9"/>
    <dbReference type="GeneID" id="26247886"/>
    <dbReference type="KEGG" id="mbrn:26247886"/>
    <dbReference type="OrthoDB" id="4928074at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028891375" evidence="1">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="31300" checksum="58148E6477638B7C" modified="2021-02-10" version="1">MALINLFLGLLVIPPTIFAAAPYGNVLASDVARTYIDDIEKYFKIAPDNPPAYKLRYVTEPTCFAYWGSCDTTYFHLKNTFVNGTAKAFYVPYTEYENANVFSEKSQMTITQSTAIVLGTSKGWNAAAKWTVSGDARGQKAALEVSGGYSSTTTGTTTTTKTVSTHAECRYGYICEIQTWTFHVLIDGMCKTRPYLNCGSEKDACKRRDRIRCKQQRTYIDKFCNHHRLSTMTPCSASMVVRNAAGEPFTTLALVSSRINSDGIPATAKRDNLEDLIVEILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTD0</accession>
    <name>A0A7D5YTD0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g066770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539544.1">
        <property type="nucleotide sequence ID" value="XM_014684058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTD0"/>
    <dbReference type="GeneID" id="26247627"/>
    <dbReference type="KEGG" id="mbrn:26247627"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="117" mass="13088" checksum="C9314AF6B7C3F266" modified="2021-02-10" version="1">MALGAQFLAKPWLPKKLRRIHEACVSFQPYMNDLYEQEKRLQNCQSVDGTARDGNLMTVLVQASTKEQKASSSTTGGWSEKEIYSNIFVFNFAGHDRTAHTLTFMVAFPASNPAAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTE2</accession>
    <name>A0A7D5YTE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g061900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542682.1">
        <property type="nucleotide sequence ID" value="XM_014687196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTE2"/>
    <dbReference type="GeneID" id="26244631"/>
    <dbReference type="KEGG" id="mbrn:26244631"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="387"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="586"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1204" mass="133958" checksum="32C0234D3A14D69F" modified="2021-02-10" version="1">MARFVPRQRKHKVLARQKAEEAAQHEVRDTNQELLPATQAERQEKKARMKEELRQDGVKVSGKKAKRLEKYIENKLRKDENRELLAKLAARRIDTSLFSSSRSLGQGKETKKQALSRALRESRAGLDGDDEILLEKRQEPAIELEDDGSDADESNVARSAKVAIESTIEKSIPNSEIPRPLVRIPDTEVIGSGLKRPLEQDDEGKPVIKKKQKRGGVKTKAPLETIEIIQPNKLEYEEWDGFDSDDEISEKNVTQPGEDTEPEVDDDTGSEEDTSDDSEGDEESEGSEKDNDAEQPAQRSSAFKAWALQQRNEALGYQPIDVTTGPSEVPKPENFVPRAPEQEPLPMELQPTANDSRKAFSVTVTRSPEIQEARMKLPVVSEEQRLMEAVHNNDIVVICGATGSGKTTQVPQFLYEAGYGSSDSPTPGMVAVTQPRRVAAVSMSRRVAEELGDHSGSVAYQIRFEGTVSDKTAIKFLTDGVLLREIAQDIALRKYSAIIIDEAHERSVNTDILIGMLSRVIKLRAELSEEDPTIKPLKLIIMSATLRIEDLTMNSTLFPTPPPVLEVEGRQHPVTIHFARKTQHDYVEEAFRKITRGHRKLPPGGFLVFLTGRNEILQLSKRLKAAFGGMTAAEGPKVKISANEAPMEVEDIEFGDVDDYGDEMGGVPSDDEEDEEEFQIEEDQEAAPLKMQVLPLYSLLPTREQLRVFEPAPDGTRQVILATNVAETSLTIPGTRFVFDCGRSKERQYDRQSGVQSYEIGWISKASANQRSGRAGRTGPGHCYRIYSSAVYERDFQQFADPELLRMPIEGIVLQLKSMNLQNVVNFPFPTPPERQSLAKAEKLLTYLCALSPSGDITQIGKTMSVFPLAPRFARILLVGHLHDCLPYTIALVAGLSAAEVFLPEAQAIPALTAKGDVEIRTTADVIAEDRQANVRRVFNEVHKNFCYLDDKSDAIKLLQVVGEFAHEPTEEWCEKHFVRFKVLKEIQQLRKQITELLRNNIPSFANLKFQDKLDPPTPKQVSALKQMAAAGFVDQVAIRADLAPAPPEQYRKPKRAIDVPYIPLVPLHAVQGPEHDSLVYIHPTSPLAHCSTQECPEYIVYSYLQRATPSGVDVPKKPKTRMHAITDVTGGQLSGLAKGTPLLSYGKPIKEVKPPAASGEGSMTRECWVIPYLRAENTGGQGWPLPAKKVKQKKVPGKGWIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVE4</accession>
    <name>A0A7D5YVE4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g008550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985913.1">
        <property type="nucleotide sequence ID" value="XM_066129652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVE4"/>
    <dbReference type="GeneID" id="90967435"/>
    <dbReference type="KEGG" id="mbrn:90967435"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="29005" checksum="9661A5F76F42A0A5" modified="2021-02-10" version="1">MAFDPGEIDELVGRVQRSRDTHQFLGFGHGGGQYYPQELLIEEQRPLGEAHTERAPSLATSATRMSSAFDAFDRSSVCTSATAPPPLYGPEMVGRHRPAVPDPIPTNLPCEFKNFSGCDVVFPSNKVNLWIHHIIGEHLNWCCPKFSICWFCDTYTFGSPSNQREEMCFRQRLYHIAGHFDEGMTAANIRPDFYFLDHIYKRHLIDESTFEWNRSQREFPNHHLPRDLRFGVRERPGEVHVEHARSTCRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVG0</accession>
    <name>A0A7D5YVG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase swnN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">swnN_0</name>
        <name evidence="5" type="ORF">G6M90_00g000140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543050.1">
        <property type="nucleotide sequence ID" value="XM_014687564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVG0"/>
    <dbReference type="GeneID" id="26244423"/>
    <dbReference type="KEGG" id="mbrn:26244423"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="36133" checksum="AB84CEF2A541C0E0" modified="2021-02-10" version="1">MSAVAVAGGLGDMGSRITGALVERGKYEVYVMSRELPKTVVPSRSPPLTTVIETDYSSVDKLAKVLESYNIQTVICAFSLDFPAASDSQINLIRASEMASTVNRFIPSEFNVDYDLPDEVLPYPHKKFHTSARRELEKTNLEFSYIYAGMFMDYFAMPNLETSLREVCFIVDPTNGVANVPGDGESRMAMSLAQDAARYTALALELDAWPRVMTTAASCISINQLITLFEENLKHRLDVTYQPIQKLTKHENKLLPRNITIADSFPGGIEQVKALTADLEASIALGSFQFDKLTDHLDLVMEFRGRTEPPMVIERLLKMAWKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVS5</accession>
    <name>A0A7D5YVS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Collagen-like protein Mcl1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g074590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545608.1">
        <property type="nucleotide sequence ID" value="XM_014690122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVS5"/>
    <dbReference type="GeneID" id="26241641"/>
    <dbReference type="KEGG" id="mbrn:26241641"/>
    <dbReference type="OrthoDB" id="4331875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028960109" description="Collagen-like protein Mcl1" evidence="2">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="26512" checksum="28748C93206088CF" modified="2021-02-10" version="1">MKHCLKFLTVSTALLLPATASRTVMRDGTDGKGMGNPAKVCYPEVNGSGVVPPCISISNIESACQPNGTESIDFNAHAQCMCQGSYFVDWRGCQNCLFVHGFRSARDHVYWERVLSVASDSLCQGTPTAPFSAIFSSVQANTRDAPFVTTGDTISLDKFPGKTDVSLYYTATGPQGPGAITGGAATATRVSHPSATNLTASNTSGNSNKNTPSRTGSGSVSENASITRPSSSTSTGGAPAQGTGMAMAIAGAALVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW03</accession>
    <name>A0A7D5YW03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MTC1</name>
        <name evidence="3" type="ORF">G6M90_00g025930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547989.1">
        <property type="nucleotide sequence ID" value="XM_014692503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW03"/>
    <dbReference type="GeneID" id="26237433"/>
    <dbReference type="KEGG" id="mbrn:26237433"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="515" mass="55169" checksum="6D231A00BC6FCC4E" modified="2021-02-10" version="1">MASKKTKAAASAADDNLDELFQGIGDDAKSKKPTNPKSTKTASSASKTQGDDDILADLESQLASEKSASRPHTPRGVRRPAGTPPVGDDKATAAAAAAPSVRKSTDSARSLRANLTPSATSSEPHEAEKKGAAEQSQQQQSGGGWWGGILSTATGVMKQAENAYKEIQQNEEAKKWADQVRGLSGGIDVGALRNYGDELRTRALPTFTNILHTLAPPISSHERLMIHITHDLVGYPSLDPLVHGVFARVMSQVEGGDLLVVQRGRESSSGRYSDGSAGWRDGPWWRQTDSTRELGLVKGMIEGTKLCRAGAESYANEYFASHGGIEQAKTRATEDLSESNPVRTSDIFLSVQAISTDGDKALFAGSASAVKEKETSAVKEQDDTDELVCFAVYVLDPVHEIEFSTVSQSIPSKWVRWLDAASPLTPRTSDENQDNPFDAGIPEDIKDIIESGGVDPREWVAEWIEETLCLSVGVVAQRYVARRMGVGEGGLGRGKKRVDELIEANAGEVARAGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWD5</accession>
    <name>A0A7D5YWD5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DCW1_9</name>
        <name evidence="14" type="ORF">G6M90_00g112500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540318.1">
        <property type="nucleotide sequence ID" value="XM_014684832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWD5"/>
    <dbReference type="GeneID" id="26246912"/>
    <dbReference type="KEGG" id="mbrn:26246912"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028897031" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="25"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI74020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="470" mass="51410" checksum="28B6F48E0029B305" modified="2021-02-10" version="1">MFSSLVSPAWLVFAGTLLIGTTGAQYYKIDTEAAIKESARTLAYDLMLFYKGNQSGEIPGILPGPPADGKGPYYWWEGGAMMGTYIDYWKLTGDSSYNKVVMEGLLHQVGENKNYMPNNHTMSLGNDDQGFWGMSALLAAENKFPDPPADQPQWLALAQAVWNTQADPSRYDETCNGGLRWQIPFSNQGYGYKNTISNGIFFNMGARLARYTNNETYAKRAEKAWDWMTGVGYIDPKSWHAYDGAHVNKNCTDVNKATFSYNAGVLIQGAAFLYNYTEGAQKWKTALDGLLDSTLKTFFPNDIAFELACERDNGSGTCTPDMLSFKGYLHRWLAVTTQVAPYTKDKILPVLRKSTEAAIKQCTGGPTQRQCGFYWSFGRFVDPAADKTTGAGEQMNVLAAVSSLLIENAEQPVTNTTGGTSLGNPNAGGKDNGERPVKPVTTADKAGAGFLTFLLLGGAVGMFVWMSAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWH3</accession>
    <name>A0A7D5YWH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540349.2">
        <property type="nucleotide sequence ID" value="XM_014684863.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWH3"/>
    <dbReference type="GeneID" id="26246943"/>
    <dbReference type="KEGG" id="mbrn:26246943"/>
    <dbReference type="OrthoDB" id="4954733at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="65215" checksum="6D4A8BD88B48E7B0" modified="2021-02-10" version="1">MAQTAGVCSFLGHPWTLEDVISIPSDSESDTDSDVEVVEQDVPRVHLVHNQHRDDSLPSISEIMASLINVRHDPTEAIGSSSEDLCLPDEWESPNSLTSNSSREVISPSMALESPGVTADSNMLVSPPIQQHDDGASVVWPTPIRRPCVVSAASECCSVQSTTALPPRDEALHHEKTDPPSRSATSLVQPSQSQNCSALFSNRFVQAHSINIGHGRMGEVVPRSDNELPSVARPASVKTPPSGCSHPVSHRGAVMEAIRKHQAPDDISPLGSCPSSSPTGQGRDDERQTSIDAGGTESQPDEPCEETEKRPTSRRGSGKPYNLRTLPPKRQLTAEQQDGGINEKLMPQRKRRRLVFRQPKKRNSQQRSDRRSDITRNRETRLLRSTTKSNDNESVANKKRPVRSGVASHEAWPLGQPVLRCTRENGTAMFQLHFTSDILWNTLVAQNDPAPKGHQTPNKLEDRRPKAGKVKYPSVCRDVYRVDCLLARWRRHTFLVKWSDATTTWEPRKHIMDEGMLNSFEASWRGFDAGVDVLKARQRAGRRQHLLRWRGRPSREDTWVYDEFLSPQLMERMEANERNGPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWS9</accession>
    <name>A0A7D5YWS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoskeleton-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g012230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549299.1">
        <property type="nucleotide sequence ID" value="XM_014693813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWS9"/>
    <dbReference type="GeneID" id="26238743"/>
    <dbReference type="KEGG" id="mbrn:26238743"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38273" checksum="5D1D3264F5FBFA19" modified="2021-02-10" version="1">MGWKEAVWSFCRDDRVHLVGIGLATFGLVRSIITVLTIIRDENKIPPKEPKAQYITQETEDSLRLDTLEKLLVHPNYSVREVATKILCDRAINDPQTLLTLLYGITRPDYEERMRCLRALALLTGQTMGLDGLAQLNSDKAYSALVRSLELSLEDAEPPDLTNSHWDEYYLRDMAERFNLMFIHELITKYPSQALIKARFVEKWLAKQKWGDDPVARRDNFKAYMHLKDNRLVDIVDKLKRSRRGLRALEQAGLIDDSRQQIRTPDMIMEIEEEIVGESPSVNRVLRPMRETSVEEQRLRRQHREAMVLNDGTRPLGREDIIERDHGSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXC8</accession>
    <name>A0A7D5YXC8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter ATP-binding protein ARB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARB1</name>
        <name evidence="7" type="ORF">G6M90_00g045030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544663.1">
        <property type="nucleotide sequence ID" value="XM_014689177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXC8"/>
    <dbReference type="GeneID" id="26242004"/>
    <dbReference type="KEGG" id="mbrn:26242004"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="87"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="398"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="619" mass="68627" checksum="CFED0DC162C12ADC" modified="2021-02-10" version="1">MPPSASKEKRLAKKAAEGKTKAGKGAKAKAKEPELDANGNVIRDDAPATSGEKLDEVKRLAEQMDKHGISDRVTTGVLSSTHASKDVKITSTSLVFHGRVLITDSTLELSFGRRYGLLGENGCGKSTLLKAIAAREFPIPEHIDIYLLNEGAPPSDLGALEWVVKEAEMELERLDKLAEKLLEDEGPESPVLIDLYDHMDKMDPSTFATRASLILTGLGFNKKTIHKKTKDMSGGWRMRVALAKALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWDRTLVLVSHSMDFLNGVCSNMIDMRDRLLQYYGGNYDSYHKTRAENETNQMKAYTKQQEEIAHIKKFIASAGTYANLVRQAKSRQKILDKMEADGFIQPVTPDKVFTFRFADVDKLPPPVLSFDNVTFSYSGDPADDLYRNLDLGFDMDSRTALVGPNGVGKSTLLRLMTGKLSPTGGSVTRHTHLKLGLYSQHSAEQLDLTKSALDFVRDKYKEKSQDYQFWRQQLGRYGLTGESQTALMGTLSEGQKSRIVFALLAIDGPNMLLLDEPTNGLDIPTIDSLADAINAFSGGVVVVSHDFRLLDKIAKQILVCENQTIQVWDGTIGDYKNYLRKKMISAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXU0</accession>
    <name>A0A7D5YXU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="primary">his-3</name>
        <name evidence="21" type="ORF">G6M90_00g059210</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544494.1">
        <property type="nucleotide sequence ID" value="XM_014689008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXU0"/>
    <dbReference type="GeneID" id="26242906"/>
    <dbReference type="KEGG" id="mbrn:26242906"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="20">
        <location>
            <begin position="220"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="858" mass="92327" checksum="E0EEF7D908686648" modified="2021-02-10" version="1">METELPLPFLVSVAVPPGLANLDGLTREEVSLLGNPFLQATPKIQDKLLRFFNRHSYEFHAHLDATSLESQDDVIALLDRGARKVFVAPDALSHYTEFGDRVLPVVSKPDISSASEHGLLVRNFDLSTPESEKFLEAAQSAKVKNLYLLPTDGAPLEKFIEAAQKANAIPILPSTGLTTDKSAAGKLLVSKVIAKYWKSDRQDGLIPTVVTDEAGVALGLAYTSEESILEALKTQTGVYQSRKRGLWVKGATSGDTQDLVRVGLDCDNDTLKFVVKQTGRFCHLQQFGCFGNLNGIPALEQTLISRKKSAPEGSYTARLFSDEKLLRAKIMEEAEELCDAKTPQDVAFEAADLIYFALTKAIGAGATLADIEANLDAKSLKVTRRPGNAKGKWAEKEGIKTEAAVPKAALAEKSADGRITMQRINSATVSEAELLKALQRPSQKSPEAILKIVTPIIDDVRKNGDKALLSYTHRFEKATSLTSPVIKAPFPPELMKLDPETIKAIDTSYENIKKFHAAQKEDKPLQVETMPGVVCGRFSRPIERVGLYIPGGTAVLPSTALMLGVPAKVAGCKKLVLASPPRADGSITPEIVYVAHKVGAESIVLAGGAQAVAAMAYGTESVSKVDKILGPGNQFVTAAKMHVSNDTNAGVSIDMPAGPSEVLVIADKDANPAFVASDLLSQAEHGVDSQVILIAVDLNEQQLKAIDDEVHNQATALPRVDIVRGSIAHSVTVQVNTIQEAMRISNEYAPEHLILQINDAAKSVDQVMNAGSVFIGEWTPESVGDYSAGVNHSLPTYGFAKQYSGVNLASFMKHITCSNLTAEGLKNVGSAVMQLAKVEELEAHRRAVEIRIKHMNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY61</accession>
    <name>A0A7D5YY61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g009370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549576.1">
        <property type="nucleotide sequence ID" value="XM_014694090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY61"/>
    <dbReference type="GeneID" id="26239020"/>
    <dbReference type="KEGG" id="mbrn:26239020"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="401"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="630" mass="69068" checksum="13EDC09DB78A9B15" modified="2021-02-10" version="1">MTKTTSTAREKELQYEVNTLKAQVELYESHIASQNQHSPGPRPSANLSPCWNTQPSRGSRASFDVAMDGRRGHIWLTQNRQRAYSQQDHPDHLMTRSISNHSELDMPYTYGGAATSFTNAPGFVNGSSRAASINGHLASVHENDTLPDVGVHPCNYLSARDWYTEQSYLASNGTYLSPDEAQSSFVPSAPPSMVSGFSALEPTQPLTRQNSSYGGSNSANMVRLPSSQSHHTDELSPHDPLQTTDVEDHCAMSAVSDTDFLAMGSRFSMTGQEYPPSTGNATLLLPTSVSQSMERSISNTSVSSAKSTGSNADRRLKEALTRTLKNGRTNVIRPKADSTFPAKTSTTAPQKKAGKIPLQKTPYQRPKGPKVFCNFCNEHPDGFRGDHELRRHLNAKHKGVVKKYVCQDPATVGIQSEVKALQPLSECKACSTGKQYGAYYNAAAHLRRTHFKPKAPRGKNKKPNDEKRGGKGGGDWPAMSELKLWFKEVNVPLDDDADECPVIAVADDEDPFMKDDNNIDWALDQAVDDDASDYDAEGDSCMPSWNPLAGLATQYQNDDVCTLRNTSVEDTQMVELSSFDQVHPVTYVDEFPLAGNDTGPYDAALLESTSSAPAPTFYAQEQSYQWSNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY71</accession>
    <name>A0A7D5YY71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein kinase fhkC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g012080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986025.1">
        <property type="nucleotide sequence ID" value="XM_066129723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY71"/>
    <dbReference type="GeneID" id="26238758"/>
    <dbReference type="KEGG" id="mbrn:26238758"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="206"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="297"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="681" mass="75176" checksum="329EA073901C34E5" modified="2021-02-10" version="1">MAPRSEKSQLKRQRGSLPEDATESKKPRRSDRLSSQTVGAVGAAAAAAADKTPIINKQHLPSPVTHVAAEESSDANKEATPTPSAGKHEDVTPRKTDEAFPQSQALSSPPQDTQPLSQFVDRHPALSDDVEDEVKEGVWGYLVPLDPKYGDKPLVLKRRNACPQPDSVDAAVNGEKTPLNTNKPAPIRAEEIFERKNAKGAASGGYLIGRHPECDIVVNEGIVSNRHCLLFTENNGTDTVAIVEDLSSNGTFVNEAIVGRNQRRELEDQDEIAVHGKARFIFRYPQSRRTSAFSQQYALLEKLGKGHFAEVYLCIERSTGQRYAVKIFTKPPGMEDKSKTEGLQQEIGVLMGVSHPNVLCLKDTFNERDRVYLVLELASEGELFNFIVMKQKLSEDETRKLFLQLFQGIKYLHERNIVHRDIKPENILLVDKNLHVKLADFGLAKIIGEESFTTTLCGTPSYVAPEILADSKQRKYTKAVDIWSLGVVLYICLCGFPPFSDELYSRDFPFTLSQQIRSGRFDYPSPYWDSVGDPALDLIDSMLIVDPERRFTVEQCLAHPWMTQNSPGVNDSTGGLVGGIAGLEVNRRAPARERTLLATLNSVQVTAQVAVGDDKAPVKVFSKNQQRITNASKEKAPDHHRAAGEFMEMGGKGDQPLFGDDSGSIYATATRTGQKGKAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYC9</accession>
    <name>A0A7D5YYC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Outer membrane autotransporter barrel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g005720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549932.2">
        <property type="nucleotide sequence ID" value="XM_014694446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYC9"/>
    <dbReference type="GeneID" id="26239376"/>
    <dbReference type="KEGG" id="mbrn:26239376"/>
    <dbReference type="OrthoDB" id="5291209at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38572" checksum="F3124EEF0F5F5F39" modified="2021-02-10" version="1">MAAHVFYNVFTIQATIPFDFSKPNAAMPFSDYISTSVKIQSDSGAISGSYTPIIDTGSCGFVISAADLSDWTQDDASGHPEGWEFLSSSKILYTGHWIPKDIYFTNAKVEVKARIPILAVETKTHCPTYNRTADNGLCPTPASAIPMPTGIRLMGVGFGREHDGMPQGTPDKNAFINIQTINGVNVTGNPNFRSGFILSKDGVTVGLTAENTAGMDFTKLAMREEPADARDWAQVEGCMSVDGSKSFTGPALIDTGISQMYMTLPLGTKVNRTSPPVLDDGSVVEIKIGPSADGKYISSENFTVGDTNGMDQGVVPSSVRLTLADPAKNAPHFNTGRHFLRKWNIAFDSDGGYFGLARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYP7</accession>
    <name>A0A7D5YYP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g021360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548411.1">
        <property type="nucleotide sequence ID" value="XM_014692925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYP7"/>
    <dbReference type="GeneID" id="26237855"/>
    <dbReference type="KEGG" id="mbrn:26237855"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="31811" checksum="2CCA5CE2A9EAD0D3" modified="2021-02-10" version="1">MTTTVCPIEALPNEVLAASLACLSTRELIQVVPVSRCFYTLATRILYRRLIDVSPLPDNRLILDCYHPSERLTTPPLSCRYLGLKRVGEQPITDESLKFSDLGKLYSSYRPVMKEESRDRRRASRRTGSKALQGDETATQDVYLDHDLLFSQLCAVTYVVKEASRPGFYISQVNTCDGVIRVWRPWLAEKANLNGAAEGLHSKIVDFDKFLWVDVGKNVGLRFRVVLGPAERLPLLSGPGDDSPVSYTLIYEELVVRTTTLLMAVEASTVQEASPSSKAIIISQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYU5</accession>
    <name>A0A7D5YYU5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ENG1</name>
        <name evidence="8" type="ORF">G6M90_00g012900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549232.1">
        <property type="nucleotide sequence ID" value="XM_014693746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYU5"/>
    <dbReference type="GeneID" id="26238676"/>
    <dbReference type="KEGG" id="mbrn:26238676"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="31"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="44972" checksum="E83B3A8CB4D448BE" modified="2021-02-10" version="1">MRYSGRFAALAGTVLFSAGIAHAGYLLDTTYDSTNFFNSFDFFTLPDPTGGFVQYVDGQTANQEGLAVYAKGGIYMGVDSKTKNPPNGRKSVRVSSKKSFTRGLFIADIAHMPGSICGTWPAFWLLGPGWPSSGEIDILEGVNAQTKNSITLHTANGCTMSNQGALPSTQFSSADCGALGASKGCQQATVDASNYGDGFNAIGGGVYATEWTSDHIAVWFFPRSNIPQDITSQNPNPASWGAPTARFVGGNTCNINNFFKDHQIIFDTTFCGQWAGDVWKNDAKCSTLAPTCQEYVSGNPEQFANAFWVVNSVKVYQQGGSPGPVQHFAAVNPSSGSVGPQDQNHPQPQTQVQPQSTQPATQPQPTNGQVWNGQPQPNSDTNSQPPPPKQDNSWNGQVWNGGGWNSKRRNRAVEKRFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ62</accession>
    <name>A0A7D5YZ62_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate--hydroxymethylglutarate CoA-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Sugct_0</name>
        <name evidence="3" type="ORF">G6M90_00g052320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540362.2">
        <property type="nucleotide sequence ID" value="XM_014684876.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ62"/>
    <dbReference type="GeneID" id="26246724"/>
    <dbReference type="KEGG" id="mbrn:26246724"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="565" mass="63180" checksum="22A15C71D9C7420A" modified="2021-02-10" version="1">MTRPETICKMDNYSVQEESARIFHEHLINNEQLGLPASIIEAAKHVQFVGIDPKPYMPTCCKMTESASALSGFVAATANAICAHRYGTEYQDVQVDTDLATLFLQSFFLPEINGKPFWQHAPLAAELDKGDLYDIQKPIHQQATNIYQAKDGKWYQLHGSLNSKPTMDMLGVQEQHVTHEEAFSIYARKVKQLDAATLERMANDDFSQPGVTCLTHEEFLASEHGRIISKEPLWTMKSIPAPSTNWPPNPHAANLKPLAGIRVIDFSRAMAGPIVSKLLALFGAEVIKISHKELPDFPITWVDLNTGKHDAEINLKDAEGKLKLAELIAGADVLVDCYRPGVLARLGFDSKSMRKINERLIYLRENCYGFQGPLAHRAGLQQISDCLVGHSWLQGQFLGLDEPVLPPLPNSDYQAGLVGAAVAMLALLERSKGDTAFDINISLTQYNIWFYRLGQYTDDQCRRLRARNPSFQARHYDGMRTLVARTHAAMIKARPELCKTPEYFTKMSGREWGLDDDISILEPPFRFSRLKLEYEVPSGARGRSKPQWSGGGELGTGNMQSVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ89</accession>
    <name>A0A7D5YZ89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">EFM7</name>
        <name evidence="7" type="ORF">G6M90_00g038930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547249.1">
        <property type="nucleotide sequence ID" value="XM_014691763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ89"/>
    <dbReference type="GeneID" id="26239812"/>
    <dbReference type="KEGG" id="mbrn:26239812"/>
    <dbReference type="OrthoDB" id="2106152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="29754" checksum="BA18736FB0B53DC0" modified="2021-02-10" version="1">MEGDEAYGTGFLMDEPEDYYPPSPPPTKQIFGMQNGKQVTLHLVGHSPTEAHHLWNGAKFISDYFEQDPSRVEGKSVLELGAGAGLPSLVAGILGARKVVMTDFPDPDLVANMQKNIDECNATVEPEGHVARTIDAAGFVWGADPEPLLARLAPACQEGDGGDGMQGGFDVLVLADLLFRHSEHGALVKTIKETMRASPDSAAYVFFTSYRPWKQDLDMGFFDVARNAGLEVEQVSERKLEKPLFEGDPGDLDVQKTVKGFIVRWRVEDCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZT1</accession>
    <name>A0A7D5YZT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g012360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549286.1">
        <property type="nucleotide sequence ID" value="XM_014693800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZT1"/>
    <dbReference type="GeneID" id="26238730"/>
    <dbReference type="KEGG" id="mbrn:26238730"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34147" checksum="D1E090CE4303CC59" modified="2021-02-10" version="1">MRKHAAPSSPTLQSVMPSLPPTPDRVSEESKPLVNRGMTIAAFDGSFAPLVRPTVRRKTPWYKDRDYFLAGWLSPAIWKAAVVEAIATSCLSYVSLLAVSTLVSYNTPRIGGYIGIFNTVLLTIFIYATSPASGGHINPMITFSAILAGICPLPRGVLYICGQLLGASLAGGILTGVWGEEKAAIIHGGGCFFTPSVTSAGQVFLNEVAASFAILYLSYGVGLDPRQAVLFGPRLGPLLVGASLGLVSFASSGIADGYGGAQANPARCFAAAIARKDMSYQWIWWFGPAVAGVLLAVFYNTIPPHHTDDQQQKERQHESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZU4</accession>
    <name>A0A7D5YZU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA splicing factor RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g102110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546135.1">
        <property type="nucleotide sequence ID" value="XM_014690649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZU4"/>
    <dbReference type="GeneID" id="26240558"/>
    <dbReference type="KEGG" id="mbrn:26240558"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36159" checksum="3CA6E49E09A9CB0E" modified="2021-02-10" version="1">MEPSQEPATAIVFRPSKKRKAYRQRAGDSPPPATTPKDTPTREQPSSQEEQDNGAESAVTAAMRVRNARRARLRGVGFSSDDHDAPAPHAPTDHQDRAPPKGIPDRFTHQTGLVATLNDRHMNEYIESRLSTHAPGPSPAPPEEEAAPARPPAGAGPGHRTHDQPTKHGKLLEVDVPADNNARRDARKRPPDTTEPARPKRGRNRRGSDDVKRDQLVDAFLHENKLDVYDVPVQNNPVAGGDGRSADDRMADEFRQRYIEEVAARRLKRRPAPTAKQQQQQQQQQADVLRGPKLGGSRNVRAAARDVLLKQKQEKERQERTGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0F8</accession>
    <name>A0A7D5Z0F8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SMP3</name>
        <name evidence="13" type="ORF">G6M90_00g013220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549199.2">
        <property type="nucleotide sequence ID" value="XM_014693713.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0F8"/>
    <dbReference type="GeneID" id="26238643"/>
    <dbReference type="KEGG" id="mbrn:26238643"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028869947" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="522" mass="59328" checksum="8CDCA725010A6760" modified="2021-02-10" version="1">MWRRTYLLLVLIRLWFALSPSYLHPDENFQGPEIIAGQIFSYPVRRTWEFTSEHPIRSVFPLWPVYGLPMLLLRWLWIGNGHDGEIPPIAVFWTLRVLMFLISFVLEDWALHELIPSPRHRRVAVLLVASSYVTWTYQTHTFSNSVETLVVAWSLVLIQRIVDTRQQSSLLSSTVLGIVAVFGVFNRITFPAFLLIPGLRLIPHFLNKPFSFVALASAALITTVIAIALDTAFYSSEPVTWANLISRPTITPLNFFLYNSDTANLAQHGIHPWYQHVAANLPQLLGPAAALVFAKPHLSLRLYSAISGLFVLSIFPHQEARFLLPTVPLILSSVELPKNKILLRTWAGAWIIFNLFLGVLMGIYHQGGVVPGQVFMSKQPDATQAIWWKTYTPPIWLLNGKNEVLQTRDVMGLKGDALLTQLTELATCDTPADRRNQEYLKEKNGTYLIAPASATWLDPYLSNKGLHGLRFREVWRYRKHLNLDDLDFGDDGIWNTLSRVIGRRGLIAWRVTKSCQKLSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0H8</accession>
    <name>A0A7D5Z0H8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g034860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546881.1">
        <property type="nucleotide sequence ID" value="XM_014691395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0H8"/>
    <dbReference type="GeneID" id="26239444"/>
    <dbReference type="KEGG" id="mbrn:26239444"/>
    <dbReference type="OrthoDB" id="4519212at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="305" mass="34268" checksum="D98725C974E74D28" modified="2021-02-10" version="1">MNPARASAHPFVTAAQLTDVEPVAEGLEFHVYKAQSPHYGPVALRIPQHKVFQNVNDPSNDARELLAQELDIYRLLHGGPVPVPRAFELLEINGFPAMLSEFIEDDGTQASPAEMGRVAALIHTSHVPEDWDTRPVAMEDGDVFTTLVNRMVRRFQQFLKHEPASKSWIPERHVLQGIAEKLRRFPPRHLHMDLRDVNLRVRRGRVVAVLDWTNCLVGPTAVDLYRIMELEKLGSEFLEAYSEVVPLPRVTAEEETLLRLDAALMIALVFISEAPDEVLRGPAVKRVQELAAMLQTPRGPDADLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0J9</accession>
    <name>A0A7D5Z0J9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g002520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985961.1">
        <property type="nucleotide sequence ID" value="XM_066129530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0J9"/>
    <dbReference type="GeneID" id="90967405"/>
    <dbReference type="KEGG" id="mbrn:90967405"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028952095" evidence="1">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="48" mass="5254" checksum="FC41B8787C5F95F4" modified="2021-02-10" version="1">MKVTLIMIQVLAAMGFASPVPEEEPTRVKRLQFCNQYGGCKPQPSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0K4</accession>
    <name>A0A7D5Z0K4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g106980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539913.1">
        <property type="nucleotide sequence ID" value="XM_014684427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0K4"/>
    <dbReference type="GeneID" id="26247352"/>
    <dbReference type="KEGG" id="mbrn:26247352"/>
    <dbReference type="OrthoDB" id="3515175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="130" mass="14812" checksum="DB953EE9830F3656" modified="2021-02-10" version="1">MAAVFSPHWKKDSGPLNPTNWKFYAVSKIHGHYYPLSVCCEENPSKLHAEGQDDSWRGRGLVSSCLRTVSIFLNPNNRREIQNELNMANSFYQNPEHLLQPTFQLPNPSKSHPTSTQDDHVSLQESGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z150</accession>
    <name>A0A7D5Z150_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="7">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">osm1</name>
        <name evidence="10" type="ORF">G6M90_00g027430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547844.1">
        <property type="nucleotide sequence ID" value="XM_014692358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z150"/>
    <dbReference type="GeneID" id="26237288"/>
    <dbReference type="KEGG" id="mbrn:26237288"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="543"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="627" mass="67180" checksum="3E5EF70CD1694DDB" modified="2021-02-10" version="1">MAPRVIVVGGGLSGLSAAHTIYLAGGNVVVLDKQGFFGGNSTKATSGINGALTRTQVEHGIPDSVKQFYDDTLKSARDKARPDLIKVLTYKSAAAVEWLQDVFDLDLTLVSRLGGHSQPRTHRGHDAKFPGMAITYALMQRIEELSETEPHRVTIIKKARVTNLNKDGNNITGVTYEADGQTASLDGPVVLATGGYAADFGDTSLLQKHRPDTMGLATTNGTHATGDGQKMVMAIGGNGIDMDKVQVHPTGLVDPKDPGSKWKFLAAEALRGEGGILLNGDGDRFCDELGHRDYVSGMIFKEKDKGKYPVRLILNSKASKTLDFHTRHYSGRGLMRKMTGQELAKEIGCTPDHLQKTFQTYNSIADGKQKDPWGKKFFHNMPVDINDDFHVALMEPVLHFTMGGIEINDKAQVLNQEKKPFDGLFACGELAGGVHGANRLGGSSLLGCVVYGRVAGDSASNYLFQQALSGSAAGAAAQRLGQISLHLDPSAPGKLTVEWANGGSGSGAVAVQQQAGAAPAAAAPAGESAAKAKPDPKAFKIPETEYTMEEVAKHNKEGDLWVVVKGVVMDLSNWLDEHPGGPQAIKNFMGRDATEEFEMLHDDEVIPKYAPEQVIGRVKGQEPTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z285</accession>
    <name>A0A7D5Z285_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL43</name>
        <name evidence="5" type="ORF">G6M90_00g014360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549086.1">
        <property type="nucleotide sequence ID" value="XM_014693600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z285"/>
    <dbReference type="GeneID" id="26238530"/>
    <dbReference type="KEGG" id="mbrn:26238530"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10153" checksum="B685084B20B57639" modified="2021-02-10" version="1">MTKRTKKVGVTGKYGTRYGASLRKQVKKMEITQHAKYTCTFCGKVTVKRHSTGIWNCKGCNRTIAGGAYVVATPAAAAMRSTLRRLREIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2A8</accession>
    <name>A0A7D5Z2A8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">NIP1</name>
        <name evidence="8" type="ORF">G6M90_00g035430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546938.1">
        <property type="nucleotide sequence ID" value="XM_014691452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2A8"/>
    <dbReference type="GeneID" id="26239501"/>
    <dbReference type="KEGG" id="mbrn:26239501"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="603"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="800"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="862" mass="97158" checksum="9817B8AE1B378EAC" modified="2021-02-10" version="1">MSRFFRGGEDSSSDSSSDEEELYSEEEQEQELGQNDSEGSDDMDDSDMSDEETSSDDEAGGANRFLRDAASDSESEEEEVRAKVKSAKDKQRDELDASIKQIENGQKNGDWTLISAEFDKLSRQVVRLQDGGKTPKPYIRIVAELEDFMNEALAKAKVTPKKMNAIQARNLNAVKQKIKKASKEYQTEVNAYREDKDGFMESEDEEPEPVKPKKVARFQEETAQPEELGDDGFATVGKGGRTLQYTPESIFKHLRGVMETRGKKNTDRVEQIKVMEKLGEIANTPYQQIRVLLAIVSARFDLSAGTSNVMPLEHWKAAEKELSTLITVLENNKDYVVVENVEEWDDDEKAPALQPGEKYIKVAGSVVSYVERLDDELVRSLQSIDPHTSEYIERLQDEGALYNIIVRGQLYYEYLRKDPALEIPQDSVNRIVMRRLEHVYFKPAQVIKTFEENCWKAAGDKVDSVITPRSQSSDANNLVIVLCNYLFSNSDGIIRARAMLCQVYFLALHGEYYNARDMMLMSHLQDTIPNFDVLTQILYNRTLVQVGLCAFRKGLVYDAQNTLQEICGSGRQKELLAQGVMMQRYSQVSPEQERLEKQRQLPFHMHINLELLECVYLTCSMLLEIPLLAQTGSSPDVKKRVISKTYRRMLEYHERQIFTGPPENTRDHVMQASKALAAGEWKKSTTFIHSIKIWELMPNAEDIKTMLSKQIQEEGLRTYLFTYAPFYDTLALDTVSAMFELDIAKVAAIVSKMISHEELAASLDQVTNNVIFRKGVELSRLQSLALTLSDKASALIETNERTLEQRTQGTSNAFERQGGRGRGGQRGGQRGGRGGARTGGHTQRQAGGTQFTGGALGAAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2F7</accession>
    <name>A0A7D5Z2F7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g084330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987398.1">
        <property type="nucleotide sequence ID" value="XM_066131247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2F7"/>
    <dbReference type="GeneID" id="26243825"/>
    <dbReference type="KEGG" id="mbrn:26243825"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69869" checksum="A1939247F15F4F3E" modified="2021-02-10" version="1">MSSLTSLNPQSAAWLPQETSVSSNESESSRGTSGYRVGGSENTCSTTTSFTGSLEGSVALELLSHEGTKSKTVDQAVVQSPEPAQHGVYSQSHYNERAFSPPRAGAGLPSSHSCHSASALLSPSTSGRLSYVGSVSETMKSPDYTRLGTLTEPRNFAPQTFGLSAAVTSEPPPKFDLSLATGVRKNDTVSTNAQTIVHTTYYPSGTDHDIGSTAIVPFADHRHVSPHSQIRNLRSDTLNHLTATESGLPALHNALDPQYFPFLEGARQAVATNHGVVKLKNIPFATKRSEVIAFLGRNSKILNDADEPVHIIMERVTSKTMDAYVEFVTLDDANKAVEKHQQNILSGRVSRLGDRPVEVELSSQESLMKDLFPLAKGIMWNGASPQFKPLNPSEPWENFKGFVSEEEMIMLVKHVEVPHRSPFSKDCPQRPYECLISTLKKFPWYVTDRITISQRHAVFKATCELARLLSRSIQKQDDQVNLTHQLYRRLIATAMKCPGFTPLMKDDISYLANLSDMEERRYNQPRFASCWRHQYSLAPKPGMPLDVIEWYIAMIREQTHRDMVARPHVERTILLEKSEETDMYWGYFWAEIGYMFGPAFDQMTLSQAAHAEFTAVERILARALTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2W3</accession>
    <name>A0A7D5Z2W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g050930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545193.1">
        <property type="nucleotide sequence ID" value="XM_014689707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2W3"/>
    <dbReference type="GeneID" id="26242534"/>
    <dbReference type="KEGG" id="mbrn:26242534"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028884814" description="CFEM domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="12">
        <location>
            <begin position="317"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI67346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="519" mass="52899" checksum="021A794815DC1C94" modified="2021-02-10" version="1">MRPLVLTLVLGLASAAVQGNFQPPNSGILQERTLGLDEILGDISSGGLLGLKAQKIAFLCKLVDKAESIAGFVGGLKLESHLKKKLEFFLKDKCKKTTQTQPPPSTSVPPPESQTSPSTTSSPPETSSPSTPPPETKTTPPETKTTPPETKPTPPETKTTPPETKTTPPETKTSPPPETTPPKETTPTPETTPPKETSPPAPPTETTPTPETTPPKETPPPPATTPETETSPPPGTTPPEETSPPTPPKETTPATPGTPPKETSPPPGTTPPNETTPGTTPPNETSPPPDTTPPKGPESSFITKTTPNNSPPPVTLPPPTPTTAPPITPTITECIDVTTAIPPCATGCFSSAGSQVGCSDKDFGCFCKPGSQEQLSMLVQQCVSTACPPESATSVSMGVSSVCSCFPNPPVPTNTGVPPTPCTPGSGDDCTQTKPQPEPTTPGVPPGCTGGEGDCSASPPKPGVTTTPSQGMPCPIVNGTGIDCTRPTSPPVVTAAADRFSFGLGGCVLGGAAWLALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z387</accession>
    <name>A0A7D5Z387_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g011940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549328.2">
        <property type="nucleotide sequence ID" value="XM_014693842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z387"/>
    <dbReference type="GeneID" id="26238772"/>
    <dbReference type="KEGG" id="mbrn:26238772"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="254" mass="28414" checksum="361D3C67B82EE455" modified="2021-02-10" version="1">MTLQQYESWYKANGIEALLVERMKAKQKKEAAKTSRTRDSTPSVILKSRRKSKRGSNKTKVKAEQDDMAQDYPLFPGFFPSEIDAEVDEEFASGDMLSLKGQVWPGMGKMDLANDDMKRTRNQRKPNSVIEKMKHISEGIEPTQVVMTPDLEVERVKGVYDSSSPIPGQEEETPKKTVRPKRKRSQALAEISVNVPRRASRRPGRRNGQSKVKASPEESNGDSILPIAASTTSLRHGNDVFRDNDDDGVSGKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3B2</accession>
    <name>A0A7D5Z3B2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g067700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540527.2">
        <property type="nucleotide sequence ID" value="XM_014685041.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3B2"/>
    <dbReference type="GeneID" id="26246634"/>
    <dbReference type="KEGG" id="mbrn:26246634"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028817748" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="181" mass="18314" checksum="2BBCAC9B24C71E88" modified="2021-02-10" version="1">MPLPALFVWALQINSPGHAATGSDVTVTWSHVDTDPAKFDLNLWNGAAQSPAVNRLLASGVPVAADAVRVSVPCGIPSSGAYQLLAVDGANSSDVYARSGQCSVAVVGCTSSATSTARTTRTSLRGVQTDATTASSSALTNVTSTPSGRGTSIPMAGAAQCTAQWLSIAGAFMLAVVAFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3B5</accession>
    <name>A0A7D5Z3B5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g075560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545543.1">
        <property type="nucleotide sequence ID" value="XM_014690057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3B5"/>
    <dbReference type="GeneID" id="26241576"/>
    <dbReference type="KEGG" id="mbrn:26241576"/>
    <dbReference type="OrthoDB" id="5555533at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037652">
        <property type="entry name" value="Mim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28230:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19117">
        <property type="entry name" value="Mim2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12610" checksum="E929E86D38DF9DFF" modified="2021-02-10" version="1">MVAAESLIDLQDTYNEKEDDIDSLPSTSSSTSDVYSDADSDAQAEWDRSLEQLQLLLTMMIIPWVGKYFGRKFAYWSWGRYMEWMHGVEVRWTNKKAFKAVGIAETAATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3E3</accession>
    <name>A0A7D5Z3E3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein SYG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g003250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541983.1">
        <property type="nucleotide sequence ID" value="XM_014686497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3E3"/>
    <dbReference type="GeneID" id="26245014"/>
    <dbReference type="KEGG" id="mbrn:26245014"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="665"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="924"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="109571" checksum="186F12496CE71686" modified="2021-02-10" version="1">MKFAKELERDAVPEWRIKYLNYKAGKKYVKAVSRAINRTPKTSANRTQSLFRSSNHGRTAILPTSSSGPPPRAPNRSNGSATPGSNPISIAAHADEDEALRGDGNDLHYGSFVPTPPKHSPLRQSEDKASRDFALPAPAISASDSLGLLKPTAAIKGRNTVPTQRRASTAEPVTATRNDIVEQSSAARRQSITGGALAESPSQLRRILSNAYGPMKRDMPWMDGGINEFDLVREREREFYAFLDSELEKVESFYKLKEDQAGQRLALLREQLHEMRNRRIHEIASNRDNDPDNGQYTDAENSKDNPNGWVQPLKAKIFPLGPNSKALRNMPNTPYLPASASAGDATRDYSRRRQKEDVSYRTAKRKLKLALQEFYRGLELLKSYALLNRTAFRKLNKKFDKAVNARPTLRYMNEKVNTAGFVNSDTLDGHIKAVEDLYARYFERGNHKLAAGKLRSLSKRSRSESGSSFINGFLIGTGLIFTVEGLVSGSQLLFDSDADLRIQTSYLLQLYAGYFLMLFMFSFFCINCFIWTKNKINYRFIFEFDQRSVLDWRRLAEFPSFFLLLLGIFMWMNFSRYGPDWLYIYYPVILISITAAIIFFPGPTLSHKSRSWFVYAHWRLLLAGFYPVEFRDFFLGDMYCSLTYSMANIELFFCLYANKWDNPSQCNSNHSRLLGFFMALPPLWRLFQCVRRYKDTCNVFPHLVNGGKYIMTILSTVMLSLYRINGTRSNLALYIAFSTINGIYVSIWDLFMDFSLLQTDARHFALRDILAFKRRWPYYFIMVADPVLRFAWIFYAIFTHDLQHSTLVAFAVSFVEIVRRGMWALFRVENEHCANVSQYKASRDVPLPYRIEPLMDRASEEMSPVLMSDEPRHDLAQSGSSTAVASTLSALRRRADTVSARSFSKILAEAHKQDFVKRRKPGEVVEDEAIEQSDEEEDEDDEDDEAEVASLLEAGEARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3M2</accession>
    <name>A0A7D5Z3M2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS siderochrome iron transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MFS1_1</name>
        <name evidence="7" type="ORF">G6M90_00g092810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541925.1">
        <property type="nucleotide sequence ID" value="XM_014686439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3M2"/>
    <dbReference type="GeneID" id="26245393"/>
    <dbReference type="KEGG" id="mbrn:26245393"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="596" mass="64853" checksum="DF345345B53FBF4D" modified="2021-02-10" version="1">MDKIKSTDGPRPPAGESDAEKGHHGVNTTAVDGSTTSGVKNDGNASDSDEFQDGVREVRAVTTVWSKTSLFSMFALLYLVSFVDYLQNNIDSILNPYITSSFGKHGLLNVGSVMSTIIGSVAPLFIAKVVDIWGRAEGFLLMVVVCVIGMIIKAVAQNVETYVAAHTMYWVGHIGIGYVMNVMLADMSSLRNRMLAIAINGTPRLVGNYAGPNIAGLFYRNLNFRWAFGAFSIILVACSAPAIGLMWSMLGKARREGVIEKRQASGRTWLQSIQFHVVEMDLVGMVLIMGALACILLPFNLVAYAPQQWETPYIIAMLVLGVLLFPAFYVWEAKIARVQFLPFRFLKQGTIIGGCLLYGVMFLSTFCWNGYFYSYLRVVHRQSLENAGYIVNTFSTTSVVFGPLVALFISYTGNFKWTAYGGVPVMLLGSALVIPFRQPNAPVGMLVFTQFLVGLGSEILVLCSSLACQAPVTHQQIAAVIALSGMFGGFGASIGLSIAGAIWNNLLPQKLYEYLPEGAKNQSMTIFGDIEQQIAFPDGSPEREAIVAALGDTMRLMVIAGVALMPLCAVCIYAWKNINVKKLEEQQGKQTKGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3V5</accession>
    <name>A0A7D5Z3V5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lanosterol synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERG7_1</name>
        <name evidence="6" type="ORF">G6M90_00g105380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541525.1">
        <property type="nucleotide sequence ID" value="XM_014686039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3V5"/>
    <dbReference type="GeneID" id="26245775"/>
    <dbReference type="KEGG" id="mbrn:26245775"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="5">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="4">
        <location>
            <begin position="317"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="605" mass="69007" checksum="1EB190E3472AF94C" modified="2021-02-10" version="1">MTFCAGIVIAWYVTETAIPDHVVTELQAYLATRVNSQDGGWGLHTTGESNICGTTINYIVMRIAGMSPYHPILIRAREFIHSHGGALYSLVWGKLWMAILGIVDWDIVHPMPAEIWLLPEYVPFHPWRFYVEMRLAGQPMSYLYSTRWRCKETDLIKSLREELVARLYGEIDWERHRTTVSKADYKQRRSRIVDGINWAYVNIWKPYLLPDFIKSRAEDWLGELIDMQARNTYHGGIAAADQPMSTIVSYSRDGAKSSSLTKYVDKMQEFLWMTGDGMLVNSTNGSQSWDTAFIVLGICAAGLHQNERWRRICVKALGCWTFSNKYQGYAVSDYTAEAIKAIIHLQTTAHYPTLLDDERIFDAVDSMILYQNSTGGVSAFEARRGSPYLELLNPTEIFTRNMVEQDYPECTSSCITALALFREYWPQYRTQDIAKFIQRGVEWIKSDQRADSSWYGSWGICYTYGTMFGLEALAAVGETYENSLNAQKACDFLISKQRQDGGWSESLQGCADQRYTESPQGSLVVQTAWALIALMAGEYPAVEPIKRGVKLLMSRQQDNGEWLEEEILGAFHGFCSFSYPNYKFSFTIRALGTFATRYPDEKVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5A8</accession>
    <name>A0A7D5Z5A8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High-affinity glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HGT1</name>
        <name evidence="11" type="ORF">G6M90_00g045360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986363.1">
        <property type="nucleotide sequence ID" value="XM_066130372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5A8"/>
    <dbReference type="GeneID" id="90967695"/>
    <dbReference type="KEGG" id="mbrn:90967695"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
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            <begin position="6"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="209"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="278"/>
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            <begin position="312"/>
            <end position="335"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="390"/>
            <end position="413"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="433"/>
            <end position="450"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="457"/>
            <end position="475"/>
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        <location>
            <begin position="9"/>
            <end position="479"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
    <sequence length="549" mass="60457" checksum="AC472F293CBEB67E" modified="2021-02-10" version="1">MVVGNIYVIAAVSVVGGGLFGFDISSLSAQLGEQSYLCYFNQGPHGPPYTNEKCSGPHELVQGGITAAMAAGSWLGALISGPLSDRLGRKYSIMVGCIIWLVGSTICCAAQNIGMLIVGRIINGLCVGIESAQVPVYIAEISPPSKRGRFIGMQQWAITWGILIMYYISYGTSFIGEQEYFGWKASSFRIPWGLQMIPAVFLFFMMIILPESPRWLARKDRWEDCRSVLALVHGKGDPDHPFVAMELQDIKDMCEFERRHSNVTYLDLFKPDMINRTLIGLFTQIWSQLTGMNVMMYYIANVFSMAGYEGNANLLASSISYIINVFMTIPALLWVDRWGRRPTLLVGSVLMATWMYANAGILANYAEVVPGGINGVAAQSMRLTGAPAKGLIACTYLFVASFAPTWGPVSWIYPPELYPLRLRGKGVAMSTSGNWAFNTALGLFVPPALANIRWKTYLIFAIFNTVAFFHVLFVFPETAGKTLEETEAMFEDPNGIKYIGTPAWKTKVVTKLVDRAEHGDVDAKRAAEYKLSDAHEHDVEKAATPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5H6</accession>
    <name>A0A7D5Z5H6_9HYPO</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="44"/>
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    <sequence length="903" mass="98331" checksum="D4D112DEA9EA828B" modified="2021-02-10" version="1">MARFSFSFTGRKKQNVPPPPTGPRMSKAHKILGSTPLNIDAPGSWDDVSSLTTSDDRSTTTGASYSESELRGHEYEHRVAIARSDEDWGEESDIIPHPLKLDAISFGNPTESVRTDTTGALRKSQSSSTIRSWYDKSKLPLSISQQTSSSAIAKGLPPNFQPGLNPAGVEEGFRSKKKPAKLMFSRTARKGSDSTCKDSVAESGLDRMLRSPSIISSFSVMSTRSRESRRFRKKHTKEDPPSPIPEPPRPVTSGSNRIGRGNTREPPSLYSHYEQMSLRNVMRQKSTPSLTMTENGILTLQNVTEVPYDGHEEEVAVHQRQKPASQNPKLTIFPKADLQSSPERSVTRRHTKTPKASKSLDRSLEGADLLQTSVLMLSSDSEEDDTEPRPTVRPSAPAPLRKPSKFETRAPPLEECRPKMVSDPKPSEERASQSTKLGKRRSVSASNTYVARPSPENRLRAPTAMSSRSGTPLGSFCPAISSPRTSVMSYSSVNSGMTWQGKSGYGVQEARAMTVLPAWRSPGAELEEKQDEASNTTSRMSRQPILNQTSSTDQLTPPLSPTSVDFYIGSAHSSIDGPGSHSRLIAVSHQEEVLLSALRQKQQAMRRASMSQVSEESEVDSVAGIKGQPENCRREQQGMESDMSSDDAQTLAKEGHRKEHQAKESQTTITGSTFEFGFPAPPSFKEDTNTHNEQSPRRLESCGVHPPIHTEGIVLRSDSIPTSPVGPPPTLALPKLPKHARNSKSLPSRDNDSTQSQRDVTLYFDDSEPSPDLSDIQGWESATAPTANAVSPDAPLATSWPEHEGGQASGKQVLPSSKLESQSFLYCDGFSELNVRNQGPNQEKEATPGGDKDIPRPDSPISPEAFPAVPARRVTLGNMARLSAVGPSLFTTAGAPGRRGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5Z8</accession>
    <name>A0A7D5Z5Z8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNA mismatch repair protein msh-2</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="primary">msh-2</name>
        <name evidence="12" type="ORF">G6M90_00g043300</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692179.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26240228"/>
    <dbReference type="KEGG" id="mbrn:26240228"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="11">
        <location>
            <begin position="734"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="922" mass="103617" checksum="109D4B5BFDDBD914" modified="2021-02-10" version="1">MASRPELKLDDEGGFIRFYKSLPDVGEDTIRIFDRGDWYTAHGDNASFIAKTVYKTTSVLRQLGRNDHTGLPSVTMTVTVFRQFLREALFKLGKRIEIWESPSGRMNWKCVKQASPGNLQDIEDDLGGQIESAPMIIAVKISAKASEARNVGVCFADASVRELGVSEFLDNDLYSNFESLLIQLGVRECLIQLDKGDKDKDPELAKLRQIIDNCGVAIAERPAGDFGTRDIEQDLARLLKDDKSVNLLPQTDLKLAMGSAASLIKYLGVLQDPSNFGQYHLYQHDLAQFMKLDAAALKALNLMPGPRDGSKTMSIYGVLNHCKTPVGSRLLAQWLKQPLMDKDEIEKRQQLVEAFFTDTELRQTMQEEHLRSVPDLYRLSKRFQRGKANLEDVVRAYQVVIRLPGFIGTFEGVMDEAYRDPLDIAYTTKLRELSDNLGKLQDMVEQTVDLDALDRHEYIIKSEYDQGLQTIRKKLNQLDRDIRAEFHEAARDLGQEADKKIFLETSHKVHGVCMRLTRQEAGCIRNKSSYQECSTQKNGVYFTTKKMQSYRREYDQLSQNYNRTQSSLVNEVVNVASSYCPVLERLAGVLAHLDVIVSLAHCSVHAPEAYVRPKIHTRGEGQTRLIGARHPCMELQDDVQFITNDLEFTRDKSSFLIITGPNMGGKSTYIRQAGVIALMAQIGCFVPCAEAELTIFDSILARVGASDSQLKGVSTFMAEMLETANILKSATKESLIIIDELGRGTSTYDGFGLAWAISEHIVKEIGCFAMFATHFHELTALADQYPQVRNLHVTAHISGTGKDNSKREVTLLYKVEPGICDQSFGIHVAELVRFPDKVVRMAKRKADELEDFTTKHEDNALAYSKEDVEEGSAMLKQLLIQWKEQVGKGEMSQEEKVSKLKELVAADSKLLANPFFQSVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z660</accession>
    <name>A0A7D5Z660_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g097180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987773.1">
        <property type="nucleotide sequence ID" value="XM_066131525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z660"/>
    <dbReference type="GeneID" id="26241046"/>
    <dbReference type="KEGG" id="mbrn:26241046"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="1">
        <location>
            <begin position="92"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="45626" checksum="B1DEA994B0F197C6" modified="2021-02-10" version="1">MASHHGSYQAVICQIGFGEPAKGTVRHSRATRFGPKTHPAPRSTLFLQFEAPVCASQVDHGTDVLTEPKQSEDVTIDRPIKLDPDALVRAVKRRRILDELVHTEEDYISDIRLLLNVYVTMLVSLPSTYHGLRQSVNRNLSDILQLHEEFLDELQRAVSNSGIKEFGHLEGVTGIPDQPLHDRTQVFSRNGRANVHRGRSTMETSELCAEPQVIVEVSKIFERQMSRFFIYKEYGAKYEMMVQETASVYDTLPDWDCNQKGLEALSALLSTRSCALRNTNRAATMKDLLVKPIQRICRYPLIFGELLKYTPVADCPNAHMAAESVLARFREATTEINQVTNDPQMRNTLSRSWLLQDRLVFPNRIRVSIRFPKIVYDLSVMFAYAELSTSVGKLQMELTANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6Q7</accession>
    <name>A0A7D5Z6Q7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mating-type switching protein swi10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g036430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547035.2">
        <property type="nucleotide sequence ID" value="XM_014691549.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6Q7"/>
    <dbReference type="GeneID" id="26239598"/>
    <dbReference type="KEGG" id="mbrn:26239598"/>
    <dbReference type="OrthoDB" id="5232891at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50703" checksum="F3130D878760AD0D" modified="2021-02-10" version="1">MSSQHPVSPISSNDSFSPTSTDGRRSRRSLIMMANNLKPTRQKLHKYFAKSRHSASESELADWNANDDLSSFFNTGSMQMGTLANPEVPISPVVVKDSRYKPSLVAPTVAIKPRNEPKHGKKFQLHYEPEPFVFDSFLAAPQQAPPPPPPIPQPDRLPPPPPLSPLPEFPQPPELPSFLEPPQPRVRRAPSVKRPRPASGIRRAKTPVRKIGQLEMAAAKKRQEAAINRQSSVRTIARQYRTLIDKTNIPDVPSVPSIHRKPLPNSAAPRINQFTSNDGPIPRLSIIEPRSGGSLDEPKPRCELAPWPESDADTLVSSPDISPYVKPLEFSSPPTPPAENGRCEDDHYEDDDYIKSPDTETLRFQIGFEMLTRELSSGFADRSSRAGRGASGLQIWVMIEAYEKLRDEISSMETQDPELQCARAMFDSWLAALRAIQKTIANEGAESDSEYGDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z775</accession>
    <name>A0A7D5Z775_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g062090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542666.1">
        <property type="nucleotide sequence ID" value="XM_014687180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z775"/>
    <dbReference type="GeneID" id="26244615"/>
    <dbReference type="KEGG" id="mbrn:26244615"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="6">
        <location>
            <begin position="74"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="7">
        <location>
            <begin position="325"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1067" mass="119309" checksum="9FFA68E6A31242E2" modified="2021-02-10" version="1">MSSNRYAGGVPTRNGNGYGNFGRAPDAYDSYSDGRPNDRSDRYGAPLGARAPPPALRNMPSRARVQETNAERQIAQVLEHIRSDWPSMCDNDSIPVQLALQLLDSSSVGRAHEYRKFQETHTYLQDSLKNIVHEHHQGFNSSIGTFHKIQGSIQASQKRVRELRESLASSKASLCSTDPELKKLSHTSTEYDELLQTLNELDDLRAVPDQLEARISEKRFLGAVEVLQNALRKLRRPELDGIGALNDLRSYLANQETALMDILVEELHEHLYLKSPYCQDRWQSLAKAQGAHGDGYGDTNHVPPFHSVLDSIDLEKAVTEDPTKNPEADTFNYVGLLVESLNRLGRLQNAVETLKQRLPVELFGVVNETINEVDQRHPSSLRGTAGKTDGVFVYNSRETQMRADVIYDLLWTLYGKFEAIGEGQRAFHEFIKALIRREGAGNNSALLGSFKELWNLYQNEIRSLLHNYVTTDADVYQFDSPNPGANFSGKKDAMREHLFKFAEADAKSVDMVTEYDALEGIIHATVPGLTSGTRKQGLDSKKNRVALDASLARRDTGQGLVGSSKQSTGSYKSLVEPSVFNMSLLLPPTLTFLQRLKTIVPPGSDLATSTLTTFLDNFLVNVFQPQLDETLSKLSDTVFGEADSFMQDQTWKQVAPRPVFKGATQFFQIVTAFCKMLGTIPPDQALSSLIVTQMRRYHDRCFTWYRSLVTKTQDHSEDANNLRASARFSIQPGPLQDIMKQVWAAEESSAAELLSKEIQALIEQTNAPPLEMNDIIQDRDIISSLCLLYTSMKWLSARISSLRYITTHNTDSSRQAQPRQAKRRWSLMNDQGKAASDQNPVHLPLTQETVQTFDNIVSSYQDLATTALLTLHAEVRTRIVYSLHTALSPSIAPYLLDQEVREPDPQILSLNLELVLFDDTIVRYLRDKEVAFIRTGLGLLINNYLVSNARLASPMNAMGCGRMQLNILVLQQNLKNVEEGVDLARAANYFALFDGGPDAIVEKAKEDKDKEAGSGAAAESFTYDELKALMELCFSEGMSNRERGIASAAKRQLDDKLLGLSEHMWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z902</accession>
    <name>A0A7D5Z902_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">las21_1</name>
        <name evidence="14" type="ORF">G6M90_00g079460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539918.2">
        <property type="nucleotide sequence ID" value="XM_014684432.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z902"/>
    <dbReference type="GeneID" id="26247256"/>
    <dbReference type="KEGG" id="mbrn:26247256"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="13">
        <location>
            <begin position="475"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI70808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="949" mass="105064" checksum="71A21F4EC0DFE4A4" modified="2021-02-10" version="1">MPIMFRKKRSRLLLLASNLMIPLGMLIFMTGLFRSRPRVAQGGDEAMHHPAPSPYRHNAPPFDKVIFMVVDALRRQVCSCRSPAWRISTTDSGGDSDFVFAQESGFPFTQSLIRSGAAIPFTALAAMPTLTVSRIKALTQGSSQSFLDAWLNVANSPEAMRLDGEDTWLSRLKASRQDKNKIVFYGIEMWVDLYPDVFDRKEDFSSFHVPGLTNVDANVTRHLPEELARDDWAALVLHYLGLDCIAHMGGPRSAHMRPKQLEMDAVVESIYRTLETAVHMERTLLILLGDHGMTAQGNHGGRLPEELAAATVFISPRLRGTTSTRRDSPAAVARDYLYYSTVSQIDIVPSLSGLLGFSIPERNAGIFIPELLSAMGDDDAATDFLVENARQLRGALASSKHGIASHASSSGDASYTDCEAHSSEFGRAMCLWDAVLEAEKDWQTAPGDEARGMLKSSIYEFAKVAQKLLSISVDNVSLGRLLIGIAFLMTAVAFTCMSFISLDLTRWPLFAATATHAATMFIPWLVEEEHHYWYWGSLAWLVYLASTRARGPDRAFIPFAGLVALQFLSQCVNQNGTKYSIAERMDDFIFRNPVALWIPVLLSHTSALMSIAQNLRAGLGRHAAFGAALALCAAAVVFKLSSTHDFNPELLGFASHHAQHFMATLRQDRLLKAFWTGLLSCLVYYLLHHRFGDSPAPSDTISKVVELFNLYLRSQTRPKNLPLFLMFDWQLQVLMKMNPSPIETATTVLLLGQSAFYSMGRSNSIATLDLLNGFNGLGESSVVGVMLQTVLSNWVGPVWWLFAGLRLLTSWAETKQEPFTGTQNGDAASSRGVQSTSKRLVKWQESEAKIHRGDTHTPATSETKANGTMKAGAEAGESPYFEYLALHTMFSGLSSLALTLACLCTWGHENLWDVFAPKFINASLWAFFHQFLMNCLGCSCLWFLINGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z905</accession>
    <name>A0A7D5Z905_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trichosetin biosynthesis cluster transcription factor TF23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TF23</name>
        <name evidence="5" type="ORF">G6M90_00g083120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543534.1">
        <property type="nucleotide sequence ID" value="XM_014688048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z905"/>
    <dbReference type="GeneID" id="26243711"/>
    <dbReference type="KEGG" id="mbrn:26243711"/>
    <dbReference type="OrthoDB" id="4935007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF74">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="224"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="600" mass="66909" checksum="BA0A3E6AB0DCDEB4" modified="2021-02-10" version="1">MAPDHATAGKLHVDDSKTAYVGGSHWKAVLESISELKTLSEEEPDDSDRPSPEQQTEYGLEDSILIPGTTRERPRLLYGWHKPASVADILAAMPEKSVVDRLVSSYFSNPPIPHVLLHPGSFSRQYERFWADPFNTPLTWIALLYGIMCLATQAETFQSLVLESSLTPQTPVPSMPPSRPQYLDQVEQSLIAGNYSNGGPFALEALLHYTIVEQTRYPDADVGTWLLTGVIVRLGLRMGYHRDPSHFPGITPFQGEMRRRIWVVMHALDVMTSLLLGLPRVIKDGQWDTMPPRNVHDSELDEGAARLPPSRPESEATPVLHLLAKHRMLVVLGAIADTSMSVAADRCDASALETERRMIARLREAYDSVPVNAKFDAVCTILSSRPSDMLNRLSITMLLQKGLIVLNWRHVMPTGSVMSPDDPVGRSGGRLKGDTEGYQICIQAALEILTVQETIDRETRPGGLLFPLTLLLYSVVKHEFLMATTVLITHMYRAAVGRPDIQQDSRERMLSQQVEVALRKSHEIWIRHSARSREAQRVANLLSVLFRKLQDADIQGLCKTRALDQTPGVQSDDQGLALFGEFGLLHHLEDLSVFFDLAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z937</accession>
    <name>A0A7D5Z937_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kap95</name>
        <name evidence="10" type="ORF">G6M90_00g061160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542752.1">
        <property type="nucleotide sequence ID" value="XM_014687266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z937"/>
    <dbReference type="GeneID" id="26244701"/>
    <dbReference type="KEGG" id="mbrn:26244701"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="874" mass="96055" checksum="B58B116D9B21021E" modified="2021-02-10" version="1">MSSSEINQVLANSLSPDANLRNAAEQQLNQAAESNFPLYLATLVQELANEQAEGPIRVAAGLALKNAFTARDFQRLQELQTKWLQRTDEDTKSRVKQLTLQTLSSSNAQAGNAAAQVISSIAAIELPRNQWTDLMPFLVKNVTEGADHQKQASLTTIGYICESSDSELRVALVSHSNAILTAVVQGARKEEANNEVRLAAITALGDSLEFVSSNFKHEGERNYIMQVVCEATQADDSRIQQGAFGCLNRIMALYYDNMRFYMEKALFGLTILGMKSDDEDVAKLAVEFWSTVCEEEINIEYDNAQVERSDQMRNFYNFARVAANEVVPVLLSLLTKQDEDATDDEYNISRAAYQCLQLYSQAVGASIITPVLQFVEANLRSEDWHFRDAAVSAFGAIMEGPDEKVLDPIVKQALPILITMMDDQSFQVRDSTAFTLGRVTDACADAIDPVQQLPTLIESLFKGLMSNAKMAPSCCWALMNLAERFAGDVGAASNPVTPHFNQAVSSLLDVTARQDAETYVRTAAYEVLNVFVQSSASDSLQAIASLSDVIIKRLQETVPLQSQVVSVEDKITLEEMQNSLCTVLQAIVIRLDKDIAPQADRIMEILLQILNSVGGKSSVPEAVFGTISALSTTMEEDFIKYMDAFAPFLYNALGNQEEPSLCSMAIGLVSDITRSMGERSQPFCDNFMNYLLNNLRSTALSNQFKPAILQCFGDIAGAITGHFETYLSVVAQVLEQASTVTATPDGPIEMVDYVISLREGIMDAWGGIIGAMRSSGKTQALQQYVPAIFNLLGQIANDTIRSEGLLRASMGVIGDLAEAYPNGQLVDAFRQEWLTAMIKETKTNREFKPQTIETARWAREQVKRQLGGAQTVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z940</accession>
    <name>A0A7D5Z940_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g089470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541609.1">
        <property type="nucleotide sequence ID" value="XM_014686123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z940"/>
    <dbReference type="GeneID" id="26245472"/>
    <dbReference type="KEGG" id="mbrn:26245472"/>
    <dbReference type="OrthoDB" id="4937683at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="253" mass="28192" checksum="5905316023C4E2A2" modified="2021-02-10" version="1">MVTVGSQEMTEVAAAITAIRRDISALRAEISEGLEKICTSTSGFDKSLLDIDGTLMRDVSARLDSLALDIMTTRVDIQALGLDIDQAHDRVCTTLDDHRSGIFKTVQDSHKATSGRLEDLSRAVVDVNSRTKHGLLETGHGLDVNHDAFVTKLDKVSEDINLTVCRKIDIANGHINKLIVDTRDHLRGRLDEVQEEVESSRRRTHEKLNDVHEALAGIVNTTRDRLLRKIEQATSLFSSVQPLMRELRRNHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z942</accession>
    <name>A0A7D5Z942_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FUR1</name>
        <name evidence="12" type="ORF">G6M90_00g088590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542256.2">
        <property type="nucleotide sequence ID" value="XM_014686770.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z942"/>
    <dbReference type="GeneID" id="26244770"/>
    <dbReference type="KEGG" id="mbrn:26244770"/>
    <dbReference type="OrthoDB" id="4932723at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="28865" checksum="0D6CBC64237D9A31" modified="2021-02-10" version="1">MSDRPVPTQCIGSSHRPTGEKPSATLSEGVNFDNVCILPQTPQLIALLSMIRNKNTERADFIFYSNRIIRLLVEEGLNHLPVIAQTITTPVGRTYDGLMFQGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEDTAQPKLFYDKLPEDIADRWVLLLDPMFATGGSAIMAVQVLKARGVPEDHILFLNIIASPEGVNNFATKFPRLKVVTAFIDQGLDEKKYDSRATNKVKLELTFVSYIIPGLGDFGDRFYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9Z8</accession>
    <name>A0A7D5Z9Z8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PEX10</name>
        <name evidence="21" type="ORF">G6M90_00g103220</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546026.1">
        <property type="nucleotide sequence ID" value="XM_014690540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9Z8"/>
    <dbReference type="GeneID" id="26240449"/>
    <dbReference type="KEGG" id="mbrn:26240449"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000395">
        <property type="entry name" value="Putative Peroxisome biosynthesis protein (Peroxin-10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI72786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="41228" checksum="52A7A40F794CA207" modified="2021-02-10" version="1">MASKPLSSPTASPTASPYPFAAAPDIVRAHQKDAYFTGHLANTISDLYRRLFGARATHSLAPELRSLAALLYFALTTLPGNRTLGEEYCDLVQVESPAGQLPDVKQRAAYIAGTILLPYLVSRTLPSLRNRLRKLIDRRLDALRRKGNQASREARVWEYISNHLPSLTSAAPIQAVTLALFYFNGTYYELTKRLLSLRYVFTRAVPDSPDRGGYEVLGVLLVIQLAVQSYLHIRSTISSAGRRERNAPPAGSAVDVSLDHTNSYSANSDLLLTELGARGPQESRVDLALTTHTPVSSSPRFDLADAQAMGYIRGSQQRKCTLCLEEMKDPSATQCGHVFCWECIGDWVREKPECPLCRREAMVQHILPLRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAD5</accession>
    <name>A0A7D5ZAD5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Meiosis protein mei2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mei2</name>
        <name evidence="5" type="ORF">G6M90_00g088500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987461.1">
        <property type="nucleotide sequence ID" value="XM_066131330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAD5"/>
    <dbReference type="GeneID" id="26244778"/>
    <dbReference type="KEGG" id="mbrn:26244778"/>
    <dbReference type="OrthoDB" id="4936538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="405"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="66986" checksum="FF09BD71289BBCD2" modified="2021-02-10" version="1">MAPGDKKFGPGIGQERDPFVTPRHRISTRLSPTASTFNPFTNVNSLGEASKSNPVATALSTELGLSRYLLIASDTHLEAEEVSIWLDDLDLHGRRFHGQRSIDTENGKVYVHFRDIRDACSTLATTLISRKSWKAEYCGSLGGHRQNPGSETESPALNTGQILLVATISPSISLDVGQVFDIAQNFLHSYGRLFAFIKIPNPSKTPSFRAIAEFCDISHATKVIANCAHVTTPEGVHLVISAYETNSTFVSPLKPTQNVTGANTQNNAQHQHMHIGSASRSVVPIEARVSHPFTMYPLMVQSPFVANVPYILDSLPPGSSQGSVSPITTLAPSFPVLGPLYHAPPSPALTVQSNYSPSRAVAGFFRSDGRRQNAARVTRSPYNNSTNHHNYVDINRIRDGIDVRTTIMLRNIPNKVDQAMLKRIIDESSWGKYDFMYLRIDFANDCNVGYAFINFVDPLDIIDFVEARGNQRWNCFKSDKIAEISYATIQGKDCLVQKFRNSSVMLEAPHYRPKLYFTCNGPCPELAGQEEPFPEPDNQSKMKRSCENAEHVGLFTPNAGQHYRDEQRRRRSQYDRGTRLAALEEYDYEAAIQNMYTITPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAK0</accession>
    <name>A0A7D5ZAK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g104230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987608.1">
        <property type="nucleotide sequence ID" value="XM_066131638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAK0"/>
    <dbReference type="GeneID" id="26245669"/>
    <dbReference type="KEGG" id="mbrn:26245669"/>
    <dbReference type="OrthoDB" id="2110578at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028914383" evidence="7">
        <location>
            <begin position="21"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="406" mass="43690" checksum="CB7197FC96BE2261" modified="2021-02-10" version="1">MLRKRVIALLTLLLGRGILADRPNDQSICDYYASQRYGASNSTTQLRLMQGIVAYAYAGGNTLPNPATNSTGIFNPGQFNGYNVYLRPWFDGSKATTNLNNQAVGVDWLDGGGTEPLIAFLNGSTKSADIKNGTNQYKLFTHWYYVFGKIYSCSQYKTFLDSSFTPLTPAYVHRFMDLNQTEVGYFIEQLIAASKYYGFSDTDAATLSTFMNARYNIRCAPPANGELYSICLANECPLAAPDANCDVYNNIQPYGLSNATTQSSTPTPVLPTTSTASSPSSTAAPTAPAGGSSSLSGGAIAGIAIGAAAASLLTAGMWLFFRRKRRAKAETPLTAEVSDARSSSGFVPQSAYGANRHGSYSSHSPYVFAASTTDSHPPTAVEWAPPQELDAENPPRVPMYYTKYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAN7</accession>
    <name>A0A7D5ZAN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitogen-activated protein kinase kinase kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ANP2</name>
        <name evidence="12" type="ORF">G6M90_00g078900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_066131096.1"/>
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    <dbReference type="OrthoDB" id="5141198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
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    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1036"/>
            <end position="1055"/>
        </location>
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            <begin position="206"/>
            <end position="452"/>
        </location>
    </feature>
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            <end position="50"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="540"/>
            <end position="590"/>
        </location>
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            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
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            <end position="504"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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        </source>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
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            <dbReference type="EMBL" id="QLI71309.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000510686"/>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAS7</accession>
    <name>A0A7D5ZAS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g114040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:90968300"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8632" checksum="CF6FB19564BE1275" modified="2021-02-10" version="1">MTADPLESDNQILSKIRNLYVTHPDNGQNITLKEGERTEPELDMLLQEDRTAALRHLLLERLPAALLPTVQLLIGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZEE5</accession>
    <name>A0A7D5ZEE5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g107310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZEE5"/>
    <dbReference type="GeneID" id="90968225"/>
    <dbReference type="KEGG" id="mbrn:90968225"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="53" mass="6219" checksum="28B3A58B02661658" modified="2021-02-10" version="1">MLWSNKILYVVILLLGNVEHKEKKTLEKLAKNMDLAVLVKLALYLINRDKKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UP93</accession>
    <name>A0A7D5UP93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rhp23</name>
        <name evidence="9" type="ORF">G6M90_00g014000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549122.1">
        <property type="nucleotide sequence ID" value="XM_014693636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UP93"/>
    <dbReference type="GeneID" id="26238566"/>
    <dbReference type="KEGG" id="mbrn:26238566"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14281">
        <property type="entry name" value="UBA2_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000175">
        <property type="entry name" value="UV excision repair protein Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000001">
        <property type="entry name" value="UV excision repair protein RAD23 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="141"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="334"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="384" mass="40142" checksum="AE2C067C403E1EEF" modified="2021-02-10" version="1">MKVTFRDLKQQKFVLEVEPTDLISAVKEKISGEKGWDPKHQKLIYSGKILKDDETVASYNIEEKGFVVCMVNKPKEKPAPAAESSAAAPPATPAQPVASTPAVPAAPAQPSTTQSAAPATPTPQRSGEAGGETGSGLAMGAERAEAITNMEAMGFERSQIEAAMRAAFNNPDRAVEYLLNGIPENIQQEQHARQAAAAGPTQATPAAPAAQEGGEDDGGVNLFDLAAQAGGGGRGGSGSGSAAAAAAAAAGATQGGADLGNLDFLRHNPQFQQLRQVVQQQPQMLEPILQQLGAGNPQLAQLIAANPDQFLSLLGESAEDDVPLPPGAQAISVTEEERDAIERLCRLGFDRDQAIQAYFACDKNEELAANFLFDQPDDDEPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPC2</accession>
    <name>A0A7D5UPC2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g015520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548976.1">
        <property type="nucleotide sequence ID" value="XM_014693490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPC2"/>
    <dbReference type="GeneID" id="26238420"/>
    <dbReference type="KEGG" id="mbrn:26238420"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI63496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="196" mass="18614" checksum="68ABFFE167820171" modified="2021-02-10" version="1">MAQQIEKVAAAAHIGAAATGNGAFLTSHGGMAVEQLKDIAADRIIPAAVGAKTFLASHGTSAGERIKSIAAEHPVAAAVIGTGAAVMAAPALLSAPALAVAGFSSSGITAGSLAATVQSGIGSVVAGSAFATLQSAGAGGAGLAIVNGVAQGVGVCAATAGGLMGFFGAKGGENEAAGDETKSNEEREDQTETQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPK5</accession>
    <name>A0A7D5UPK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DPS1</name>
        <name evidence="14" type="ORF">G6M90_00g007270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549783.1">
        <property type="nucleotide sequence ID" value="XM_014694297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPK5"/>
    <dbReference type="GeneID" id="26239227"/>
    <dbReference type="KEGG" id="mbrn:26239227"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="283"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI63735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="913" mass="102553" checksum="79A562F36D9F9370" modified="2021-02-10" version="1">MPGASSLLASAFGLPRSRSQSRSRTASPNKRGDVTDATYSADWTTSSTPLNSAPDSPSVPATPTFAGSAFGSPRHLPKMADSAVDVARDSARSSMEKLSLTNYRQELDKLNEKSQRSSPDRTGDSSRSSMESGRTSMSADWPTHPYELNPIAELDKLPLGSEVNFRARISTQRQLSKNLDFLLFRDQTNTVQGVLSREYLDMVRWVQKLNSESLVQVNGVLKAPPEAVRSATHSGVEVEVHSIHLVNAAHGAPFTNYKPPETLRNRMTSRILDLRHPSNQALFRIRSMVTRMFRETLEQQGFVEINTPKLQPAATESGAAVFKVNYFGRNAFLAQSPQLAKQSAVSADFGRVYEVGPVFRAENSNTHRHLTEYTGLDIEMSIEHDYHEVICVIDEFLKNVFTSVYAMPEVKEVQKRWPSKEFKWLEETLILNFEDGIQMLRDDGRDVEMEDLSTPDEIRLGELVREKYGTDYYVLDKFPASARPFYTHKDPENPFWTRSFDIFIRGQEICSGGQRIHDAAELRENMQAVGISEDGMEDYLAAFDLGAPPHAGAGLGLERIVAWMLELGDVRYASLFHRDPKSLPERAPGLPHPDADTTKPLRDGAMPPVEKLIANYGDASNTSWLDERFKIWRHPSGAAVGYVKQDKFAMITGDPLCDKTQYKDVCAAFVKFVLSELKLTPVWMLVSYEIQKILAQQMSWRTLSCTEEQRVDATKHHAINGGGPKARRVEREGVKIHEVKPDADFIRRADEAIVNWKANRKGKQVHLTEVRPWIDMEHRRYYAAEKDGKVLAMVVLAKLSPKHGWQVKWALDFPGSVNGAIEVLIEYTLSTITGQVTFGVGVSEKLTPGEHLHGIRARFLATTYSSIVDSLGLRRKAGFRSKFGALGEEVYICYPKHGVGLRDLQQIIKFFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPM9</accession>
    <name>A0A7D5UPM9_9HYPO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g009720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPM9"/>
    <dbReference type="GeneID" id="90967442"/>
    <dbReference type="KEGG" id="mbrn:90967442"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10471" checksum="9629DA53EBBFEF73" modified="2021-02-10" version="1">MLWFLFTISGQPSVRPEDSYSKAAAYGERRCVKLFNRPQCLATFDALQTLNFEEEGATPVGPINTILKALVSVKATFTVGSLKLQKRILFSASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPZ7</accession>
    <name>A0A7D5UPZ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g009910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014694039.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26238969"/>
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    <dbReference type="OrthoDB" id="4940605at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="31572" checksum="553779E493AC7B57" modified="2021-02-10" version="1">MTRPVPLPDNNKVKDHPSSTDATGASASASASASASASASTHSKRHRSTTTMTPEQLARKRANDRNAQRAIRARRKAQVSHLEAELETLRNKPHACCRKLLQRNLELECELAMMKGSPLPCPSATPAHTDEGTSTHASPEMHRINCQLESPTFPPGGDMEDSMSARTSAGALLLSPAGGCDLDSSMSGETTSPAAVMSTIYPKCGLESRDAPLQGAVAAAYAAESINATCMANPGLDVVTCGQVCPQARIPSPALPGLWPAGTPPYATNAGGIMDGLVHVALEVPCQSMMPAASAIPSTHFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ70</accession>
    <name>A0A7D5UQ70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g029710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541200.1">
        <property type="nucleotide sequence ID" value="XM_014685714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ70"/>
    <dbReference type="GeneID" id="26245835"/>
    <dbReference type="KEGG" id="mbrn:26245835"/>
    <dbReference type="OrthoDB" id="5151719at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="3">
        <location>
            <begin position="110"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="185" mass="21132" checksum="2161507587D88F16" modified="2021-02-10" version="1">MAPRETTTASGSNETQEGPTTISAHKMLAKIIRLRERVQQIEEERQEQATTTATIKKDLGEILRPRAPGPYNRSPGALQGFLTQLRAYHQQFPNKIEKSSVKVLHAGGYMTGVALTWFKPIMRDYLNKEKDNREKETNTIFKSYDEFKKAIKKAFRTVDKARAAEYYIDGLKQKGSVSDYAARFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQI0</accession>
    <name>A0A7D5UQI0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein rnc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnc1</name>
        <name evidence="5" type="ORF">G6M90_00g013800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549142.1">
        <property type="nucleotide sequence ID" value="XM_014693656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQI0"/>
    <dbReference type="GeneID" id="26238586"/>
    <dbReference type="KEGG" id="mbrn:26238586"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="284"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI63732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="368" mass="39384" checksum="A3A711430077FCEB" modified="2021-02-10" version="1">MSAPQDVLSANGNDLVDHLDQLKMEERLGPDGEPAPKTDEEYAQAQLTLRAIVSSKEAGVIIGKGGKNVADLRDETGVKAGVSKVVQGVHDRVLTITGECDAISRAYAIVARALLEGAPAMGMGGIVQSNGTHPIKLLISHNQMGTIIGRQGLKIKHIQDVSGVRMVAQKEMLPQSTERIVEVQGTPDGIQRAVWEICKCLVDDWQRGTGTVLYNPVVRTQAGSGSLGSNYNNGGGRSDYGSPRVMRTGNGADFSNGGVRPFSRRSDSDAASRGPPTHDENGEEIQTQNISIPADMVGCIIGRAGSKISEIRKTSGARISIAKAPHDETGERMFTIMGTAKANESALFLLYENLEAEKMRRSQLQEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQR3</accession>
    <name>A0A7D5UQR3_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g021580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548390.1">
        <property type="nucleotide sequence ID" value="XM_014692904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQR3"/>
    <dbReference type="GeneID" id="26237834"/>
    <dbReference type="KEGG" id="mbrn:26237834"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="46873" checksum="3530C0AA50E7A9D7" modified="2021-02-10" version="1">METPPSPSLSNTPRPRLARTSSVSPQNTTTEPQMPVSIKREEEEDRHPVIETIDLFDQGYESSVDAPVTAAADLRLELEQEKRSYPGASTWADEEEKLFEILFQRADIPLLPAHWHVDFRGIPVVDSIFSAGDGVPSIIYSRSMEKEFQATMALIRLIDLTSSVRTTVQSGLRKKATQLIKRCLDKYIAWAAEDGGYSHLKIVPNITTAVMDAELGEKDITSTMKNRMRALAMAQREFLRVDRDDSFWDVSEVRGGEKGADLSTLIVEKYLKRVEELSESAKAPSRNGSRQGTPRPGSASRDDTTPTRRRSPPSPISNGLTPDEQQSTRGQIKYRYRPPVVYGLFILRTSVFLLTVDSAKGDSAYVSFHVDMHFMDRHQSVWNALTAAIAVCLARDQLSERTDEFEELSASAEESESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQU9</accession>
    <name>A0A7D5UQU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g005340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686696.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245213"/>
    <dbReference type="KEGG" id="mbrn:26245213"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028885586" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="40"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="580" mass="64665" checksum="93419EC455C57FCD" modified="2021-02-10" version="1">MLSRLITLGACLLPAWGAHALASSADLPVITLPWGKWQAEVDKTDPLLYVFRNVRFGAEPQRFGPSDFPTWANDSIQRPGSISCISVNIEGLSKPPGGRVPLKDPESFEVPQDEDCLFLDIYVPVRAFEPNARKLSVIVWIYGGAFALGSKNDGEILYTGRPIIKASNYNTIFITGNYRTGAFGFLAGDYMQKAGLPNAGLYDQALLFKWVSKYVEQVGGDKEKVSAWGESAGAGSILHHLIRQDGKIDPGFQTYYAMSPAYEMSWDNAPDGRLDTYYRMYSKFADCGDKYDIDCLRRADRTKLVKANQELFDTVRQTGLFPVGPAVDGEWIRTIPSILLSEGKSWPGIESGIISHCSNESANFNPKGVNNEGDFDKFLETFLPGSPLAPQRLEIKDFYDCPRTHGGNFSACLETVIRDAVFTCNTRYMFEAYPDKSYMMEYAFASRESGFHGVDLIPLFTKNVAEAKEFLEKMNIAPFWAGIYADALHKTISPKFTKYLASFAVSGDPNGAGLRPLWPMARDTEQGVLDDVMQVREILALQKFRLGKDDQNKKDSCDLWLKIAHEVRHKPEGALGQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQX7</accession>
    <name>A0A7D5UQX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-repressible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grg-1_0</name>
        <name evidence="2" type="ORF">G6M90_00g029150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985808.1">
        <property type="nucleotide sequence ID" value="XM_066130023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQX7"/>
    <dbReference type="GeneID" id="90967559"/>
    <dbReference type="KEGG" id="mbrn:90967559"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="69" mass="7302" checksum="AA463F11B162E772" modified="2021-02-10" version="1">MESLKQGANYVSEQAKKATTGTSKEVNKDIAKDSDATLGERASAAKDAVSDKASEQKHGAKAEVHKQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQZ6</accession>
    <name>A0A7D5UQZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">G6M90_00g024480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985838.1">
        <property type="nucleotide sequence ID" value="XM_066129940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQZ6"/>
    <dbReference type="GeneID" id="90967524"/>
    <dbReference type="KEGG" id="mbrn:90967524"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI64815.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
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        <source>
            <dbReference type="Pfam" id="PF12417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="346" mass="38895" checksum="C47907776E2FA4D8" modified="2021-02-10" version="1">MESDLSLTASGSLRQIGFGNCGSVWGTLKHNAHNNASVDQNVDVDMILKREDASPGRDIKNETLVQSQAFRAASTLQLTSIPQCFGLVKSDDKRWQQLLPLLPSGLKACRAMIAEKINPVSTQAQLLLIDKYCPAPHREALRRSIEARDGEGEHCLVRLYLGRRRHLYAHEEQHRPRPQFFSLRNYPLHADQAHDLGLPCRQYARAMAEALATLHWQVRTSGNDVEFVLGAHRGGEGDADMPLEEHAVWMLDFDCSRPIEANDSGLESIARAFWRNDPYFPRPGSALDQGRELWDIFAAEYRRVGMEAARAYHRDGEDVESLCALVEGALERIEETKGKWTAGAHF</sequence>
</entry>
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                <person name="Kouvelis V.N."/>
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            </authorList>
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            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="30327" checksum="3DC6D2B1650CEA0E" modified="2021-02-10" version="1">MSSTLTTRVSTTAYPPSVVTSFPRNPLTTTFSRPSDCDGIYLSGFLAMVDLSSTCLPSNFKSDAYFSPGLVCPSGYVSACHDTTGVASITTVTCCPALKNPDVTLGCLTTSTLSGSWSTLYCTWIAPPSSDSILPVTTSENGITTTQTFGFHSPEGLNAFGIRMVYQSSDLSTKPTESTTHRSASRPSGGAATSNASQDTDEPGGLSTGAKVAIGVVIPVVAIAALLGAFFWWRKRKHRYQVPPQAADKSPTPRHAELHGTPFHELMAQPNNPVELAGSNPGNESGPGK</sequence>
</entry>
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    <name>A0A7D5URB8_9HYPO</name>
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            <fullName evidence="4">TLC domain-containing protein</fullName>
        </recommendedName>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="26245993"/>
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="55"/>
        </location>
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        <location>
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            <end position="97"/>
        </location>
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        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34083" checksum="A5783F6548572BAB" modified="2021-02-10" version="1">MHQHAGSHGPHLAQLVNQLVSQIAPFSGLILTIAACILAAIRIYLLDLVVIPKFYSPRVLKDLTDAQLRSFVNHHVAAGTKILLIIVTAYPLLAILVGYGTPHTPFSPGSSTTLGDVLIVSSQIFTVMYIFELFYRDNISPISFAHHVGAIIIAQSAIAMSIDFDHQSDAVYEFILCFIWGMILPPRSPPVSLPTKPINASTGTFDVLAELWPHIAMIIYRTHNSKHVLLSRLFYTTMALELVGTTVETVVVMWLFGSLWDKWSLSLKVVTPLLHFLFSAAQLWGAWIFYKLAKDQRLRHVQSAKN</sequence>
</entry>
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    <accession>A0A7D5URG1</accession>
    <name>A0A7D5URG1_9HYPO</name>
    <protein>
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            <fullName evidence="3">Xylosyltransferase oxt</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxt</name>
        <name evidence="3" type="ORF">G6M90_00g013930</name>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="74764at2759"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF11">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="522"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="640" mass="68343" checksum="3B2A7FA4DB017DCA" modified="2021-02-10" version="1">MKLYAIAAVAALVGTGFSAKNERTFAVLRFTNKQLTKGRMDPIVSPGQVSTHVHSIFGGSNFGLGSTGKDLMDSKCTTAMIKGDNSNYWVPSLYFKDPKTGKLEDVELFYANAYYFFEPTNDDIKAFPVGLSIMSGDQTIRTPPKDGATSNLDPSKGTVNPIKWTCPRSNFDSPSWPAGSNGLAAGIQDPNNKGEGVGFPDVNCDGYASPLRADVHFPSCYNPAAGLTNYKENMAFPTDDGKGKQDCPKGWIHVPHLFLEVYWNTPLFKDRWEQGKGQQPFVLSNGDATGYSNHADFMAAWDEKLLQHIIDTCNAGSQGMDKCPGLNGLNKDDCTIKSQVDETVDGVLDALPGDNPITGWSYGGNGTEGGGNEPKPSQSQSTGGDNTAKPSSTNKAGGDNTSTAKPTNSQPAQPTNSQPAQPTNSQPTQPTNSKPTGGDNTSKVSSAAPTSDNKPTSTKNPDNATTKTQPTSEAGSSKPTLPSQPSACTPKIHTVYETITVTAQLPGATDRPVSNSTRTAGDFKYAGCFKDSRDRVLKDDVRPNLGAISNAKCVAHCKAKGYNLAGTEYGGQCYCGNELVRSEKLDDSACNIACEDDKSDTCGGGWALTVFSKDGEASLKDVKSRRHAHEHLQRHRSPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USS5</accession>
    <name>A0A7D5USS5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3'(2'),5'-bisphosphate nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MET22</name>
        <name evidence="7" type="ORF">G6M90_00g011860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985886.1">
        <property type="nucleotide sequence ID" value="XM_066129719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USS5"/>
    <dbReference type="GeneID" id="90967453"/>
    <dbReference type="KEGG" id="mbrn:90967453"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF2">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="346" mass="37116" checksum="F9023FD231E0C4EF" modified="2021-02-10" version="1">MPSSWERELSVAQSAVLKAAKLTKGVLSSVTEVSKADSSPVTVADFAAQALLIGILHAEFPDDKFVGEEDSAVLRRDEDLRDKVYALYSAARGDGHASSSVDEMLALIDMGGRGTGGPRGRFWAMDPVDGTATFLTGGQYAVSLALLEDGREVLAAVVYPNLRLEGGRIREDSVDGVGLGVMLSGARGEGARVTRLAGLDGPWEAERLPRLAASEGANLHVVDCDRNRASHRGVMRRVCEELGAGFPGTDVWSSHVRYAALIIGGGDFLVRIPSGREAWSCVWDHAGAQLIYREVGGRITDLDGREVDFSRGRYLSGNRGLVMAREGIHDEVLRAARRAVGDGWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USS6</accession>
    <name>A0A7D5USS6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoprotease family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g012880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549234.1">
        <property type="nucleotide sequence ID" value="XM_014693748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USS6"/>
    <dbReference type="GeneID" id="26238678"/>
    <dbReference type="KEGG" id="mbrn:26238678"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111332" checksum="12B7479F9F7A88C4" modified="2021-02-10" version="1">MNPPPEYHNGPLAPTNTPKAVEEWEDDDVITPIDATEQVHICPPTSAPAPLPSRNTKSVNLRASRLSTPKVRRIRSRQRQKAQNAKAGIRLITDMSVFRRNNHVTNNMRSPPGRKGKFVDADALRALEGEPSSASVGNWNWLKKGSGKTPEPATEMRKGRNKDQQLSPEDRPIVIGISLESSDVEGREISPQNPPVDDSRSPFPVPELSNPHAPKAAKADVQGHKSVWSPDTPDTSYSFGSNNVASSVYSQFIMPNQIPKEQACPPVPELPPNYKKAAHQRVLSLELGKSRQGDDESGTPCTLFEEDGVPSPQRHPKSREFDRSPDSAASRSHGWWDHVVTPFVDKKMSFSSQKYKAESPKSPKSPKFHKGMSRDELWENLDVKEESRSRLSPNVAPARVQAPIVRAPAPQYDTKHGKNPQSLFTKTQTSAAEPSMRQTPQIVISRDSPSPSDIPPPYSPPKREQEGKPIRYRAVFPPGHPLHSQFPPTPRPASPGLAGTMTSQRGQQKGAPNHASAVPTTQTQPITTQPLPVRAVGTFVPQEHAYSAAGSRHKVERQRRRHEKEDIIARRAGGFWRGRGCMSSGGCFGRTGPEGRKRRRVWMAIWAGIIVLILLIILLAVLLTRNHSPAETPSIWVNLTDFPPMPTGVLTVVGPDNTAARSVCTEPSTLWSCSLPKDQQSSVLPYKANQPTLIMQIQWDNGTRRSWNVANADAPAPLSRRAFGAASHALSALRRDPVPTEFFPDPAAPKFREMWFLGETTDNIKSDQKGGEPAPFYISLLRSTNDTVPTPNLSRRGVSPNIGNTTFKDLIPPPDLEKDGTSAPAVMIPNPVQQPIRLFDRGLPTEHYGFYTYFKRTIFLKSVNIQNNTDNNIPLDEDGGCRKTEASHLVTWGDTRLHVQIWTRALSSNTSSLLKADGSKGIGGTGELVRPGTMPYPVTITQDTHGGDPDKKLVWDRPIDDRLQVTTTEAQALVNDMGIGGTWVNKRGTGDAKFGGFDGGSGGCKCEWVNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT01</accession>
    <name>A0A7D5UT01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g011790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986059.1">
        <property type="nucleotide sequence ID" value="XM_066129717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT01"/>
    <dbReference type="GeneID" id="26238787"/>
    <dbReference type="KEGG" id="mbrn:26238787"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="428" mass="48119" checksum="9CA8E2D968D9DFFA" modified="2021-02-10" version="1">MASNGNLARQDVDRGFVILAVGWIECGITALFVTGRVYSRFQKRGGLGADDWLILISFILAVAFMGVTTPEVQYGTGRHLEFLSEDEKIQSVKLDWVSQAFHIMSTAVAKISIVLFIRQIIGKGHSRMWFLYIMVAMLFVISVVCVAFIFAQCTPAAALWDPRLSEVGKCWDPKVQQGYGYFTASFSVFSDFALAVFPVTVLWNLHMEWRLKMSLMFFMGLGAFAGIASIIKTMKLETLSSRGDYTYETVDLIIWMMTEQFCIIIAACIPPMRSLFVNIYRKVFNIQSTHDASTNKTGGTKSRQGYVNQPSQNEEHGLSRMESGYWRNETEISAAAYRSEPDGDNSSGHADRRSDSDELLREQHRGIVKRTEVMVSEHRILDADIIPKKGRPLAPAFNCGCRVEKHVSTMIKPVNGYDDMTTTTKHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT20</accession>
    <name>A0A7D5UT20_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiotically up-regulated 154 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mug154</name>
        <name evidence="7" type="ORF">G6M90_00g005540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542200.1">
        <property type="nucleotide sequence ID" value="XM_014686714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT20"/>
    <dbReference type="GeneID" id="26245231"/>
    <dbReference type="KEGG" id="mbrn:26245231"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="477" mass="52940" checksum="114A83F3EE275344" modified="2021-02-10" version="1">MPRLVRRRPLWDRITSTLNPMDFLLWLSEEIETRDWDSGLVGTQLGLGLNFLFLVVRANSGSKQASDDIFGDDGSSRWLSMLIYPLSWGLIAFSIINAIYTVSRSRKYRLFEANIDVKPSTSSVRRVKVQSSPVASSPLRFIADMITSDSAESRAHPDKSRDVWELSVWDPLPVCVRLACLFSPGHVLVYLIFLPLAPLDPRPSVTVFNSLIMQVVLSAQMLLLSSRYLQQAKDSAIVQKEVFHEYDAKFVQPRIHPIVRDVGTQMSDDQPVISREFVQVGTPTTLIRRSFISHGNPHVDSEEATPIKRFNSPSLRAGNVMKPQIFTPATASRRTELFTPALSSHRSSGIRHSLPAGYTPSSNVPAAYTPAPPSTSTVGTSTGMNTNFGGSLGVYAHQKSPLKKAISMGDMNSDNFSPRGSREAAAYEQSGQEPPSSPTKYSEKRRFTSTNINSSPHPFANMGKHSASERFPKRWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT26</accession>
    <name>A0A7D5UT26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromatin modification-related protein EAF7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EAF7</name>
        <name evidence="9" type="ORF">G6M90_00g024080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548172.1">
        <property type="nucleotide sequence ID" value="XM_014692686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT26"/>
    <dbReference type="GeneID" id="26237616"/>
    <dbReference type="KEGG" id="mbrn:26237616"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="146"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="36956" checksum="C792210BB96118C4" modified="2021-02-10" version="1">MPPRKRARGQAVATPSATRDDDAMDIDTPAASEAGDPSKHDVSNYNNMWTDDQVASLFKGVIRWKPAGMHKHFRMIAISEHLRNHGFDPDIYQHTRIPNIWDKLRTYYNLDLIDEREYFDDDETEDKYVDFTLPHSHFLDSMMQRAVADSSEAPTSPPQLELSPELSHARKRKRSGTASKARATDAEDTEDGTDAPSPAARPARGSRGRTRAASQQAKPEKNDKSDKGKDKAEKDKAETTEEEEDAENQEEESGSGEDEDEDEDEDEDEDEDEDEGEGEGEGEEEEEDEEDEADESAEEGGTPASRSTRAARKRTVAPKPTTRRTRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTD2</accession>
    <name>A0A7D5UTD2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g002950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986083.1">
        <property type="nucleotide sequence ID" value="XM_066129542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTD2"/>
    <dbReference type="GeneID" id="26244161"/>
    <dbReference type="KEGG" id="mbrn:26244161"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="288"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="621" mass="70021" checksum="73DDE5CAC137CDE5" modified="2021-02-10" version="1">MPVQTTIAKVTSVALRISAILFFRFFPAHFPSITFALFAIYIPAYFASYRAGPALEIVDDEVDVTVKQTTLTSETPLLSETGQPPEPEVVAQEVDVEETIILGEKTERPWKVLLYGYPSATQPKWSIITLLINVVLALLTADALFRARWYYSSEDLSFVRLGYVSPSEANFLVREPDQAKLPVTLQIRAKTSEASVDAPAWSNAADIQQTTNETDFTQALTVSLRYSEQRWYEWRTSNNHSGEFLSPPKPGSMPTVNDGKFTFLSTSCILPRFPYNPMDHALAIPGLRHLARKLPDLGAQFMLFLGDFIYVDVPERFGKSSEEYRMQYRQVYASPDWAPVAQNLSWIHVLDDHEISNDWSSNTTGIYSAAVGPWHTYQANVNPPKAVQAGTRSTPRQDATWYEFVQGPVSFFMLDTRSYRSSNNAPFEEESKTMLGQDQLADFLAWLGRPEPKGVKWKFVASSVPFTKNWPVNVKDTWGGFLFERRKILEAMWEAGARGTPVVILSGDRHEFAATKFPPPPESNWPESAAAHEFSTSPLNQFASPFPTYKQVDSEDVKLHYIPSGSSKFGSFTIENIDGQSILQYTLYIDGEERWTTQLSAPIVEEAAKTSGSFWDRFKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTG5</accession>
    <name>A0A7D5UTG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g051420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986158.1">
        <property type="nucleotide sequence ID" value="XM_066130510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTG5"/>
    <dbReference type="GeneID" id="26247382"/>
    <dbReference type="KEGG" id="mbrn:26247382"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="445"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="3">
        <location>
            <begin position="723"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1024" mass="119455" checksum="ABB81D6DDCCA7837" modified="2021-02-10" version="1">MVVFDGHEYLTEEERRLKQDRERTKYWKKWGPYVAERQWATVREDYSADGDAWSHFTHEHARSRAFRWGEDGIAGVSDTHGLQNIAFSFWNEEDDFLKERLFGLSNPQGNHGESVKEAHFHVDNTPHSYMKFLYKYPQKKFPYQDLIQENGRRGKEDKEYQIIDTGVFDENRYWDIFIETAKESDDPDELLFRVTAWNRGPDPAPLHIIPQVWFRNTWSWGHESEDKRPSIAAESELSAKSKHYSLGDRYVYYSPSPGVGSSGEDVVPLWMFTENDTNYELLYEQKNKQPYVKDAFHRYVVGGEKAAINPSKTGTKSAAWFNFNEDGGVNPGECAVVRFRFSKKNMTYLDEEEFDDVIEKRREEADEFYYRISPLPISDDLRNIQRQAFSGMMWTKQHYHFIWDQWAKGDPSSPPPPPERMGIRNSQWRHMHCDDILSMPDSWEYPFFAAWDSAFHCIPLAMIDPDFAKKQLDLFTREWYCHPNGQLPAYEWNFGDVNPPVHAWATFRTFKIERKMYGRQDLDFLERVFQKLLLNFTWWVNRKDTDGKNVFEGGFLGLDNIGLFNRSEPLPTGGVLEQADSTGWMAFYCLSMLNIALELAKHRRIYEDIASKFFEHFILISDAMTFRTGHKDEKSLWNEEDGFYYDAISWGGPYIQQLPVRSLVGLIPLYATATLEPELLNKLPSFRKRVEWFVQHREDMAERNMASIRKRGKGDRLLLSIVSKDRLEKILKRMLDEKEFFSDHGIRSLSKFHKESPFSMEVNGQQFKVGYVPGDSDTGLFGGNSNWRGPIWLCVNFLLVESLQRFYLFYGPEFQVECPTGSGDYMHLGKVAEEIQHRLQHLFARTDDGRRSINAGDDRLDFDEHWKDYLWFYEFFDGDCGRGLGATHQCGWTGLIARMIHDTGTNCRLPQTPRTPSAAMAHYFDDMLQRGLDLGTPRSPSMRRIRRSSTARSIGARSDFEASANGVDDDAHSVTNSVIHDDSERAREREEADSHLHRYISDQLERYKDESVNGGHADEYETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTN4</accession>
    <name>A0A7D5UTN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g041600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547503.1">
        <property type="nucleotide sequence ID" value="XM_014692017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTN4"/>
    <dbReference type="GeneID" id="26240066"/>
    <dbReference type="KEGG" id="mbrn:26240066"/>
    <dbReference type="OrthoDB" id="5329749at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29719" checksum="37F5C0AAE76145B8" modified="2021-02-10" version="1">MDSNAQQDSPLSTTSNIVGILTFVVAIAAAIYARLNYLRNSDEEYFRVKTSLSWYKTESTWLSDLLRTLGVQYAHDGGAHSRQREYQMYSFVMEDLINLEQRLLDLVTEVESKASTPRGPGNRDDRWTLVPSWQRSTPSVGMAWMSVRTKALELVRQREALTARVQFLQMSMISSRLSDLEARTKWGEFKADENSRKMDGVVESRKGEYNRLETLVQQLLVHGRDAVRLDSPENLTTNPYAGNRRVSVVALDDENWQMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU26</accession>
    <name>A0A7D5UU26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lactamase-like protein aptB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aptB</name>
        <name evidence="7" type="ORF">G6M90_00g042340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547572.1">
        <property type="nucleotide sequence ID" value="XM_014692086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU26"/>
    <dbReference type="GeneID" id="26240135"/>
    <dbReference type="KEGG" id="mbrn:26240135"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="187"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="31143" checksum="808FD5ACF4BBDAC3" modified="2021-02-10" version="1">MATQLTPLPAVERLSPLCIRILGGNPGKFTLQGTNTYLLGRGARRILIDTGEGRPAWIASLKSTLAEERATVDTVLISHWHHDHTGGIADVLSTAPGAAIYKHDPELGHKGIVDGQKFHVDGVSLTAIHTPGHTKDHMVFVLAEEDAMFTADNVLGQGTAVFEDMSEYLRSLHQMRQLFSGRAYPGHGPVVEDGPGKITEYIEHRQQRVDQVLQTMRGGNDGIDANGTRWSAMDLVKIIYSDVPDALHQAACNGVLQILEKLASDGIVIKHGRDLWQVNREKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
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            <begin position="190"/>
            <end position="896"/>
        </location>
    </feature>
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            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
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            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
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            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
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            <begin position="232"/>
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        </location>
    </feature>
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            <begin position="279"/>
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        </location>
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    </feature>
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            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
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            <begin position="420"/>
            <end position="439"/>
        </location>
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            <begin position="440"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1019" mass="110536" checksum="27143C3F046BF9C1" modified="2021-02-10" version="1">MNRFRTKKKGRDDNSIVGRPSIDAEPSGPFRMFSKKKMQDEEPKPEIDLSTALPSHNDFRTSLLMTGLSARFSMLREQDDPNSKLGKASDDSVLFSKRQSRLADFGVFTGGLDDIAEIESLKAPPLGRFDSYQSDDASSTTGSIMGRSKPTEGNNLFGGRQKIYKLSAGSKAGMTGRALYDDDVAQSSFQKWRQAEKERKSLEESQKNDTFDAEATLNYSRRRETSSTTSSVPSGARNSTAATSIASQPSSIKESSSTSHLAGLERSVTRTRRLYEQGLTQDLQDQQTSALSRMDTLSRQRPFGSRTPDPASIVPSPTIATFGDRVSDRRPIVSKASAPNLRSFSPSTMSSSQMSPVDSSSKFPRQETKPIFGGNPPLSPPISETEEHPPLAIQPNDRGKATAMGVFTRPAMQYDESRYTQRQRQLQQGRDSSTSRHTTASAGSSVAGRSRSSSAQRPSVEKSAPKAASSETSTLNENCGSTFFDDSDDGSMNIRASAAPQLKIDRPSDHDHPAFRKSALPTPLSLTSPKDSEHGGSLSPAPKTEPPEDSPTLGPNAGLSGMVRQHLRHDSTASSVYGSTSHEVEPSVTETKAVSVRDDDGVSDVANAVEQDEFAQNLAERAQRVRERLTSYVESDNERSAPPTPPQPEHNKDLGASKSGSLGMLRSKSSRGSLLDRSDKERGRSKTLKSPSPQPSRVATSPSPRKASSSRGEPRNGEVSVQSNEPALPGKEENVHVGLKAFRQARRELQKMKELETQQRHSQKPSPNPERPPPNSRITSYENGPPPAIFNRMPRDPRDGESYRSRSRAGSRAASERDRSGSETSNSGRAYSRGPGLRNGAATYEDHYGRRGLSGSPGPEIRRQPMETSGMSPYMSTGPSPVMSPSHSVGGFEAPGRQHFPVMQSPQQPDVHAFTRSRNGSLLGAAASTPNLHGGPGAPPLPPINPRRKNIFPRPSDENLGHHVPNRVFGVGEKDIIAEPYRGRMPMNPHQSRQSPPRVVRPAIPHSAMPSAGLPGGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUJ4</accession>
    <name>A0A7D5UUJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">G6M90_00g031070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUJ4"/>
    <dbReference type="GeneID" id="26247543"/>
    <dbReference type="KEGG" id="mbrn:26247543"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
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        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="419" mass="45569" checksum="06D1BF6C4A5D0868" modified="2021-02-10" version="1">MGSKDHRKGDKAPDTPNHDAQAREEADVQSTNAPSVQHVSEKEQEQPAAQKKRQKAWLHCRRFYLWYLLGVIVFLVIFLPLLFKVIIPAIIQAIIAKQGIPLVTGEANTTSAEHVVLSVGTTLNTPLGATLDPFTLLLYDEKTKPFTPFFNLSIPKIHANKETDIQINAETMTVLNETELVSWADGLVDQDERLIWIRGDPKVHFGSLSATPRVDRSVAVPGLKGLQGFGLKDVALMLPPDKDGRNVVGSATVPNWGSLHINVGNVSLNVYTGDVRIGLVTLYDVFLAPGNNTVYLNGTVDIDHIIQNLGPVLNSQAASLSRGLIEVNVTGNATFMNGQRVTYVEDILKGRKFKASLSITKLLSVLVGGLVGNGSDGDLVRVVGDLFGNESFVDHVAGHWNITKNASTKDTGSRAFSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUM0</accession>
    <name>A0A7D5UUM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g041240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26240033"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
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        <location>
            <begin position="278"/>
            <end position="316"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35122" checksum="F092C42EB72EE444" modified="2021-02-10" version="1">MSRTQVVQVQSVYTPIKDAMQRHENGVTKNRKAPLTGSGRAWREDEEAYLLQTRLQKMPYKHIAAHLNKTELACRLHYHQLSHGSTRRKRTASCSSGSSDPSPNQPAAYSSPVYRGETRSLSPSVAATSYLPKPLNSDMQLSRIMSVERSPRLPAILPKPEGVAYSQGGEVVPRHPMVTPEQHHEPLPPVVGMHHHGSPAYQSPVPPLRLDTGRLSPPSTSVHTPAHVDLGRLRSIYETHKSAFWAVIADEYGMNASPVALEQAWKTGACCQYSESNPITPIASPDKDRRTGYRMTGQDKTRISSILDDDNEQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUQ2</accession>
    <name>A0A7D5UUQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">alg-2</name>
        <name evidence="15" type="ORF">G6M90_00g032030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543138.1">
        <property type="nucleotide sequence ID" value="XM_014687652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUQ2"/>
    <dbReference type="GeneID" id="26243939"/>
    <dbReference type="KEGG" id="mbrn:26243939"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="245"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="491" mass="53009" checksum="8082FD5C1874034E" modified="2021-02-10" version="1">MDASTPNPPTLGTDAVGSTIVFFHPDLGIGGAERLVVDAAVGLQTRGHKVVIFTNHCDPTHCFDECRDGNPPPPFLTLEVCLLLKKIPPQGTLDVRVRGNSIVPPSIFSRLTILCAILRHIHLLLTIHLTGELAALSPRAFIVDQLSAGLPLMRFLAPDVPVLFYCHFPDLLLAQGRQSLVKRLYRVPFDRLEEWSMGFAHAVAVNSKFTRGIVGNTWPALQNKVPINVVYPCVDTHTTHETAPDEAKLAAGKKLILSINRFERKKDIGLAIRAFAQIPEEQRRGARLVLAGGYDARVSENVLYHAELQALATSLSLAHHTLTPAELGSAAAPPDAQVLFLLSVPGALKAALLRAARLLVYTPANEHFGIVPLEAMLARVPVLAANTGGPVETVADRETGWLRDPADAPAWTNAMARCLALPDDQLAAMGDAGRRRVRELFGRDKMAQTLDESLVQIAGLAEERRVSGAAGFGVLAAFIAVCAVLAAWFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUR2</accession>
    <name>A0A7D5UUR2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MET2</name>
        <name evidence="11" type="ORF">G6M90_00g047590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544877.1">
        <property type="nucleotide sequence ID" value="XM_014689391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUR2"/>
    <dbReference type="GeneID" id="26242218"/>
    <dbReference type="KEGG" id="mbrn:26242218"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057215">
        <property type="entry name" value="DUF7893"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF54">
        <property type="entry name" value="DNA METHYLTRANSFERASE DIM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25423">
        <property type="entry name" value="DUF7893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="397"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1097"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1166" mass="130361" checksum="E53B8B7CC91736BB" modified="2021-02-10" version="1">MRSELEASETERDTTVLKETLDTEDVWACENDSASCQDDSSQWSETLRASSSSPSVLSEESSNLAVEIPDFQLSSPRSCYEPFHPPAPPKSEEDALECFGPSVQRQSSPSSGHFELQLDEFAVYLDTENYPCEMRCLHHLYARPGYSNFFFDGILSNNGQGKTFMKRVPISAVPVGQYGLQYHNVGNQIWLQSTYCDQSDIFYKLCLPAREYRRFFKAFLWVANLAKHFVDFLVFMEEKGTRVTIRHFQSAFGDWLLVVHGDAPDLMDWLAQHASSDFRTSVNANISFLYKEYRGIITDREYGYHDIWAEIWDFTKYPDLSTGTAQEPTIVTDYVYHRFSDLPFGNRLHNFPLSRRASELRERASLKHGLELACTSHGPATSSFVNETGGDISDITRAIKPGDTISTRRDGEVSRSMRRRELSNDFAGVDRRFALVQKVCERSDGGRYFEVLWYYRPSDTLCGLMKYPWRNELFLSDHCSCAEENKIQDCEALRVHSVQFRGDSTTTSEFFCRQRYLSKEKKWIALDDSDLMCSHLNPRLQDSTSGKYRPGDTFLIHVNVASSTSEACELISVNTRGAGTRLCFRKLLRRSNVDSMAVTSARNELVYSNESIECDPSGIVGKCHVRFFAHDENIPAPYNRAGVGGYFYITHRVSPAGLCVPLRSVPSSLRQGFDPAVVISELRGLDLFCGGGNFGRGLEEGGAVRMSWANDCNARAIHTYMANCSHPNLMSPFLGSIDDFQREAFSGNFSKSVPTIGSVDFISGGSPCPGFSTLTNDRTTDEQRKNQSLVAAFASCVDLYRPKYGLLENVPGILPSKANREQDVLGQFMCAIVGIGYQAQVFYLDASSCGSAQRRSRVFISFAAPNCKLPGKPQQTHSHPSETRYTSLGKLPTRRHVLAERDFLRATPFSYSVARQVSSGLPKIYNGQTDTCIPFPDHRLARGLTKGLKARISLIPNRPWGMNLRSASRGILTPAERGVFVTINRKTSRPNTEPHKLDRQSSAYGRLYPNQLIGAITTVQVPNDRKHGRQLHWDENRGLSVMEARRAQGFLDGEVILGTPAEQYKIVGNSVAREVALALGLSIREAWAESCADDQDTEAAKPLSSSLGTGALGGNADHGPRHTSAAEASIRTRVIPQKRRRRATSRMVVVTGRAKEKCPPECIDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUZ9</accession>
    <name>A0A7D5UUZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g042330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986374.1">
        <property type="nucleotide sequence ID" value="XM_066130297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUZ9"/>
    <dbReference type="GeneID" id="26240134"/>
    <dbReference type="KEGG" id="mbrn:26240134"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="237"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="60875" checksum="3F6B7E3CA64CBA3E" modified="2021-02-10" version="1">MAVHGSDYPPTYFGTSNSRGLIYGHISLMVIGWVFVLPVAVMLSIAHSQVALAVQFAFLAVNAFGVSLGVMYNSQTQDLYPNNAHHKIGWIITAVMFAQVLIHLVGRQVGAMAGRRCRSSGGRSSVSHTNYWQRVLMQYQDGENRLSNDSGQGTEPGTESLRSNSVSTLDGEDMSLNDQRKDFEGSEAEEDSLESAEMPFLSQNSIPGKTIRAISSRIWVYLDFVYRVTDRIILPFGFIALTTGIITFGRFFEGNAVFSGLAHWIKGGVFFWLGLFSLGRWSGSFADVGWAWNLRPINFHEKRWCPSAEFVESALIFFYGSTNIFLEHLGNWGGEWSSQDLEHLAITVLFLGGGMCGMLIESSTIRSLLNTTAADTAPENVPDEEAMKKWKSPDTYQFSLNPIPALVILLLGIMMSSHHQETEISTMVHKQWGDLLLGASFARVLTYFLLFLRPPKSVLPSRPPTELLTSFGLIAGGIIFMASSSDTIDGMIHYHLDAMFMYTITMGLVGLLMAWEIFVLAIKGWATHREQRAGVQGHLTGGFLLMNSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV77</accession>
    <name>A0A7D5UV77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KGD2</name>
        <name evidence="15" type="ORF">G6M90_00g042400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547578.1">
        <property type="nucleotide sequence ID" value="XM_014692092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV77"/>
    <dbReference type="GeneID" id="26240141"/>
    <dbReference type="KEGG" id="mbrn:26240141"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="430" mass="46975" checksum="8C7BF4A2A03A3173" modified="2021-02-10" version="1">MLSRRIATAARMAPLRSMHPLRSNYLAMLPPLMQTVRTYSDKVVKVPQMAESISEGTLKQFSKSIGDFVEQDEEIATIETDKIDVAVNAPEAGTIKEFLASEEDTVTVGQDLVRIELGGAPSGSKEEPAASKDEAKEATESEPVKTETKPQQSQTSLNPEPKQTEKPATTRAASKEAQSAQSEPSQTSTASASTGSREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSNIMEFRKLYKDDVLKKTGVKLGFMSAFSRAAVLAMRDIPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRDVESMDLVTIEKAIADMGKKARDGKLTIEDMAGGTFTISNGGVFGSLMGTPIINLPQSAVLGLHAIKDRAVAVNGKVEIRPMMYLALTYDHRLLDGREAVQFLVKVKEYIEDPRRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVE1</accession>
    <name>A0A7D5UVE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HMGA</name>
        <name evidence="2" type="ORF">G6M90_00g037710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547131.1">
        <property type="nucleotide sequence ID" value="XM_014691645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVE1"/>
    <dbReference type="GeneID" id="26239694"/>
    <dbReference type="KEGG" id="mbrn:26239694"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="226" mass="23886" checksum="DC1765CC0744DC39" modified="2021-02-10" version="1">MPPATLARLEQYTACDISDALLKLKVPGAGFIADLNPYSTKSGKDADTLTIAPVSTILFAAKGEVLSEPQPNVPKDTHWSDATEPGTFVVMKQPSGQTNAICGGIMALRMKMRDAKGIIVAGRVRDVQELKSTNLPILAHGLSTVGSGGGSVPWAMQVPLDINGVTVSPGDIAFQDPVNGVVIIPKDKVGQVLEMLPKLIAADDKVKQDVLKGMSVYDAFKLHRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVM7</accession>
    <name>A0A7D5UVM7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase AFC3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AFC3_0</name>
        <name evidence="7" type="ORF">G6M90_00g032330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986484.1">
        <property type="nucleotide sequence ID" value="XM_066130104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVM7"/>
    <dbReference type="GeneID" id="26243969"/>
    <dbReference type="KEGG" id="mbrn:26243969"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="325" mass="36692" checksum="212F77642D9B66CC" modified="2021-02-10" version="1">MINEPIDEELLPGDRLRSFHPTRPGEMLNGRFKTITKLGYGVGSPVWLAENIVFENSADKSAPRYVAVKIAALDLDAGWEAGVSKFIANAEPSHVGLDFIRTHIDIKVDNIMMTIEGEAVKHQMKSPQPKHIRIQDGRETYLSQGNFGPLQGSRLLPKLADFNIAFPVLANGNGHLSAIQSHRFRAPEVILGCPWSYSVEIWNLGLLMWNLMEGIGLFDRPAGEDGEYNAHVHLAQMVSLLGEPDEECMKRERFFRNYRLEKPVVNSRGKECNAMTEFWVGPFFNDENDIVRTDLVERKRLEDTVTELVGHEKDVFLDFASGMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVW3</accession>
    <name>A0A7D5UVW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ENA5</name>
        <name evidence="25" type="ORF">G6M90_00g064200</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540122.1">
        <property type="nucleotide sequence ID" value="XM_014684636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVW3"/>
    <dbReference type="GeneID" id="26247158"/>
    <dbReference type="KEGG" id="mbrn:26247158"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02086">
        <property type="entry name" value="P-type_ATPase_Na_ENA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="916"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1001"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="24">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1054"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QLI68654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120030" checksum="7A75FD6569F6FB8A" modified="2021-02-10" version="1">MAAKEKDDVQAHVSGQANKPMTAPAHALTIEEVVHQLQANVEAGLSTDEAKRRLEEHGRNEFGEQDGVQPLKIFIGQIANALTLVLILAMAASFGIQSWIEGGVISAVIILNIVVGFFQEFKAAKTMDSLRSLSSPTAQAIRNGDNETVVTAEIVPGDMVELKTGDTIPADIRLIEAVNFETNEALLTGESLPVRKEPVPTYADDTGPGDRLNVAYSSSTVTKGRARGVVFATGLYTEIGQIAAALRGKSSRRREPKRREDGTTSFGRWLQAWSLTFSDAVGRFLGVNVGTPLQKKLSKLALLLLGTAIICAIIVLGANRFDAKQEVIIYAVATGLSMIPASLVVVLTITMAAGTKRMVQRHVIVRNLKSLEALGAVSNICSDKTGTLTQGTMIVKKAWIPGRGTYSVGTTSEPFNPTVGQLGLKLAQPKDINFRGNDADGEPIDGTEAVTKDATLREYLNVASLANLATVNQVNGEWHGRGDPTEIAMQVFASRFDWNRLRLSTGEKAQWQQVAEFPFDSDVKKMSVIFENKETNKQWLFTKGAVERLVNSCPRYAVGDEIQDLTEDIKEDVLRNMEAMARLGLRVLALASRTDIRHVKDNEAELERGDFEQDLIFRGLIGLYDPPRPESASSVQKCHEAGISVHMLTGDHPETARAIALEVGILPSKMNEIATDVAKTMVMAASDFDRLTDQEIDELPLLPLVVARCAPQTKVRMIEALHRRKRFVAMTGDGVNDSPSLKRADVGIAMGQAGSDVAKEASDIVLTDDNFASILNAVEEGRRMFDNIQKFILHVLAENIAQACTLLVGLAFKDRRGISVFPLAPVEILWIIMITSGMPDMGLGFEVAAPDIMQRPPQNLKQGVFTPELLVDMVVYGLWMSALCLASFVLVLYGFGNGAADLGDNCNNQFSEDCRVVFRARSTTFACLTWFALFLAWEMVNMRRSFFRMQPKSKRYFTQWIIDAWRNQFLFWAIVAGFVTMFPIIYIPGLNTVVFKHAGISWEWGIVFVEAFLFFLGIEAWKWAKRVYYRRQARKASDIKADLETRTFGHYFTGGNLSSEDEDESNFDSEANTEARGRHTGANGEKEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW12</accession>
    <name>A0A7D5UW12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RING finger protein ETP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ETP1</name>
        <name evidence="5" type="ORF">G6M90_00g038130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986549.1">
        <property type="nucleotide sequence ID" value="XM_066130234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW12"/>
    <dbReference type="GeneID" id="26239735"/>
    <dbReference type="KEGG" id="mbrn:26239735"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="4">
        <location>
            <begin position="344"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="627"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="659" mass="73226" checksum="A5B19319A0536A5F" modified="2021-02-10" version="1">MTSYFYHLKFELYPTPNPTGASGDQQAEQAHLWLPSPDTNVFDDLPSHPHPVRPATGAVPSSETSHSFSADGPCSSLASSSLDSLPDGVIDCGVSRAPVRRSDKRLEIITERQWLERVNSYPPPPSSAALRPQTAVKDWRFGRVNIETIDPAAAGAAVGMAGESSRAGPSAAPALGPSYGGEGTATKASFIPCETKNTEVGWGVVHFYREGDETTVFGASLQEQGQEEEQEETSSLQDCTTLCIPAVPVYMSPSDLLGFVGERWLEDISHCRMVMTSSMNRYLVLLKFRDSRFAKKWKREFDGKVFNSVEPQPCHVVFVKSITFETPKLSQRADYSKAQSSSSAVSSSLKPFPPPTPNLIELPTCPLEGIRLSRLSVHEYVRVGRHSQRSGQPVLTAIWIVGIKPMYSGHAKDHWKDTAHSFALELETQHVWDYAGDLWVHRLIRDKGDGKVVELPNRSNQSGRSLDEDVVPRAKLDNIGLEYTQLLMSQLESQRSYYEEMLSKAVDKAAKAAAAAESMALQSSAATEKLNELEEKFKSLTADTIPQLERDLERERNKASKSDKLARNMGKSLQEEKRVNEGLMKRIEHLGSENEKAMEQLGEMKSEVEELKEMNRDLSMFISGQEKLKQLENEGQLEEGELQEGSASVPEKKGRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWQ0</accession>
    <name>A0A7D5UWQ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Siderophore iron transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sit1_0</name>
        <name evidence="10" type="ORF">G6M90_00g053510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540474.1">
        <property type="nucleotide sequence ID" value="XM_014684988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWQ0"/>
    <dbReference type="GeneID" id="26246836"/>
    <dbReference type="KEGG" id="mbrn:26246836"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
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    </dbReference>
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        <location>
            <begin position="123"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="377"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="435"/>
            <end position="457"/>
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        <location>
            <begin position="478"/>
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        <location>
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        <location>
            <begin position="1"/>
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            <begin position="1"/>
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        <source>
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            <dbReference type="EMBL" id="QLI68698.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    <sequence length="594" mass="65011" checksum="CBC263CD07C5BADE" modified="2021-02-10" version="1">MPRSTSQTPLFGRISQSSQHVHEQTSLLPSQPDAGRVRSRAPGVARMEIVASQLTTAERAWLFFGIFLVGYAYGLESQVRSTYQPYATSSFSLHSYLSTINVLRSVIAVAVQPTAAKIADIFGRFEIVVASTLCYVVGMAIESTASSVYAFCVGAIIYQVGYTCIVLLLEVLVADFSSMRARVFFSYIPALPFVVNTWISGNVTSAVLAVTTWRWGIGMWCIIYPICSLPLITTLYKIDRRVSLPKHGAPKNFRDRWNFLGLGKSTKGLADQLDVVGLVTMVGGFSFILAPVSIIGTTTEHWRNPYVILSLGIGFVLVPIFIIWERRGAKTPLVPFHLLTDRGVWSALAVRSLLNFAWYVQGNYLYTVLIVAFDFSIGTATRILSFYSFFGVISGVIVGLVVYRVRRLKAIIVGGTILFTVAFVVLYNFPGGATARSHAGIISGQVLMGLASGLFAYPTQASIQASATRDHVAILTGLYLSFYNVGSAFGTCLAGAIWSQALYPTLKQNLAFQPNETLARDIYKSPFPIVAQYPVGTEIRSAIIESYKSVQLLLCTAGLCLCIPMIAFALALRNPKLSERQVQEDALETDEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWQ9</accession>
    <name>A0A7D5UWQ9_9HYPO</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="4" type="primary">gst3</name>
        <name evidence="4" type="ORF">G6M90_00g045920</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the GST superfamily.</text>
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            <begin position="1"/>
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            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI68577.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
    <sequence length="220" mass="24480" checksum="4A27EC5306DAE498" modified="2021-02-10" version="1">MGLTVHHLGVSQSERIPFLCEELGVEYTLKLYKRAPTLAPDEYKALHPQGTAPVIQDGDVTLAESGACMEYISRRFASGKLFVEPSDPAYADFIYWWHWANGTFQPTVGRVMMARAAGMAGDHWLVALGQSRLEAALGELNKRLGSHKWLAGEQFSAADVMLMFSLTTMRYWAPYSLDGYPGILGYIERVSRREAYQRAMKKSDPDMELVLGAEAPASIV</sequence>
</entry>
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    <accession>A0A7D5UXF2</accession>
    <name>A0A7D5UXF2_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">Protein argonaute 10</fullName>
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        <name evidence="3" type="primary">AGO10</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="QLI68052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014691720.1"/>
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    <dbReference type="GeneID" id="26239769"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ArgoL2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="657"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112586" checksum="A14B25A9CEAA2416" modified="2021-02-10" version="1">MSDRGGRGGAYRGGGGGRGRGDFQGSFRGSRGGSDRGGRGGFRGGRGGAPPNESRSKVFSIDGRIPSPDQTVTELENRIISQHESAVKGLTTKMGALTVQQKSASPDTFPERPAFGSSGKSVLLWANYFPVHFKIPVLYRYVLRVTEEVSSAAKGKEKTEVKDVKGRKLHLAIEHLLRHFTSTDKSRALASQFKDQIVSVKPLDLHKNPISISIPSENDDREPDVVDILIDGPTEIRISDIMTYTQTMDDHGDRNTYPKFPEMIDALNMILGHNARSKLGEITAIGGSRFFPFNKDSTTASLAQDYHTLIAARGFFQSARLATGRLLLNTNVTHGVFRVAGKMDQLMKSLAIQQVARDDHRLKRLVGAFAKFLPKARVWVTFTIADGTKVRRSKALQGLVTKITASTAEGPNRPTINMDYEYPGPKNVRFWLEEESRFISVHDYYKRKYGMTLQDFPVLNLGTPKRPSFFPAEVIEIQPGQSVRAKLTGEETTAMLAFACRTPYENALSISSDARNVLEYDGNETLQKFGVTVDKNLATVNGRVLNVPAVAYIDATKKKISVNPFNGSWNMRAVKVVKKGDMISRWTYMNLLSRDTDRQVGLETMEDFAKFMANDLGMNIAKSPVRLPKHFMTKDGALYGPGLVNFFKWAEDNKIQYIMFILGQKDSGGLYTKIKRLGDCVHGIHTSCLVAKHLFKEKNFSYYSNVGLKINLKSGGVNHKLTNDFGLLKEGKTMLVGYDVTHPTNMNVVKGNEPPSLVGLVASVDQDLGQWPAMAWEQKSKQEMLGSTLTDAFKSRLSLWRAHNNKTLPENIVIFRDGVSEGQFAQVIDQELPMIRDACRQTYQSGKQPKISIIVSVKRHQTRFYPTNTEDMSRSGNVKNGTVVDRGITLAPYWDFFLTAHEALQGTARPAHYTVLLDEVFRYKYGERAANELERLTHELCYLYGRATKAVSICPPAYYADIVCERARAHRPEYDVSDVESVSTSTSSESSGAGSIRQVHKSLRDTMYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXJ0</accession>
    <name>A0A7D5UXJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Highly reducing polyketide synthase alnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">alnA_4</name>
        <name evidence="5" type="ORF">G6M90_00g060860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544653.2">
        <property type="nucleotide sequence ID" value="XM_014689167.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXJ0"/>
    <dbReference type="GeneID" id="26243065"/>
    <dbReference type="KEGG" id="mbrn:26243065"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="4">
        <location>
            <begin position="20"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="44353" checksum="B936D3CA0B2770D7" modified="2021-02-10" version="1">MVHPRIECNGHGAVRNDEFLEPIAIVGAACRLAGEASSLHGLWDMMQNSRTAHAKVPEERWHADAWYHPDPDRKGSLNTTHGFFLEQDVAAFDAPFFSVTAKEAAGMDPAKRLVLEVSYEAFENVGAMLAAGISEEEAEAYLATMPSETVVTACQSIAKDGNFARKLRVVTAYHSPHMRMVADDCLRAMVEAGVRGANQEAKIPMFSSVTGQFIDPIEVGKSYWIRNMCGTVRFSEAVSSLLVGSSGRRAGRKATVKWDALLEVGPHAALKAPLVQIMESIDAKLPSELLYTCLLVRKEDAVTTALKAVGSLWATGIPILLAKVNREQDLVESPQVVVDLPCYAWNHERVYWHETPATKEQRLRQKTRTDLLGIAVENHCPKDQANYSPASLKGSSAAISNSRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXS2</accession>
    <name>A0A7D5UXS2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g058570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544432.1">
        <property type="nucleotide sequence ID" value="XM_014688946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXS2"/>
    <dbReference type="GeneID" id="26242844"/>
    <dbReference type="KEGG" id="mbrn:26242844"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="389"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="664"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="789" mass="86776" checksum="2D761D20E553E781" modified="2021-02-10" version="1">MANESTPLIQTVRVAPPRRRYRHDTCRRFCTIACTCVLALGFASFLTHVFLIWPYHHHHGHHSHYSHSHQQGKRLSHQEVQKILLETPTADHAEEWSRYYTSGPHLAGKNFSQADWTREKWQSWGVDASIAEYDVYINYPLDHSLSLLKKSEKDNSWTVTFDASLTEAVLDEDPTTALDTRVPTFHGYSASGNVTGQFVYVNYGTYQDYQDLVDAGINLKGKIAIARYGGIFRGLKVKRAQELGMVGTVIYSDPGDDGDKTEANGYEQYPKGPARHESSVQRGSVQFLSIRPGDPTTPGYPSKPGVPRAPADDSIPSIPSIPISYVDALPILKALNGHGPKASDLSDHWTRNLGLGYKGIDYNVGPSPAHVLLNLHNEQEYVTTPQWDVIGVVNGTIPNEVIVVGNHRDAWIAGGAGDPNSGSAVLNEVVRSVGKAVEAGWKPLRTIVFGSWDGEEYGLIGSTEWVEEYLPWLSDANVAYINVDVAASGPSFGASAAPLLNQVLRDATHKVPSPNQTVPGQSVGDVWDGKISTMGSGSDFTAFQDFAGVPSIDMGFKAGSNGPVYHYHSNYDSFHWMHEYGDPGFKYHLAMSRVLGVLLSELADTIVIPFGATEYADALGAYLDQVEAKLKSNEDPATDEAMFAMRGAALSKDAKGSADAFEASLRKIRASLSKLRTKAVGLDERAAWANKKLRDGIPWWNIIGKIKLWTTIAKVNVQYKFFERHFLFEGGLDKRSWFKHVVFAPGLWTGYSGAVYPGLVESIDAKDYINGLKWAGIIDRCVNKAAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXV2</accession>
    <name>A0A7D5UXV2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor himD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">himD_2</name>
        <name evidence="7" type="ORF">G6M90_00g046310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544758.2">
        <property type="nucleotide sequence ID" value="XM_014689272.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXV2"/>
    <dbReference type="GeneID" id="26242099"/>
    <dbReference type="KEGG" id="mbrn:26242099"/>
    <dbReference type="OrthoDB" id="5152952at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="605" mass="65510" checksum="3C8615F7253D167E" modified="2021-02-10" version="1">MTCDVPAPSQRRKRGKSSRVALLEQKIDGIMSLLAENQHGQRQPGPSPMTPESQLAHKTGPAIPQVLQTEPPRSTGSGNQALFRLIPDFQVTDREASRFLSIYASEYAPNFPFVMVPSAATAHGLHDRSPGLFWAIMTAVAPQSLAVQQRVKTWFRQYVADHVIVRQEKTLQLLQAILVHLAWGDFHFYINAEATNLLHLALALATDLRLDKSPESSAATIRSQLGEAWTALHQGGPSRLGIPHTLDDQRAVLGLYHLSSLISALFKRGPRFPWTPYLSQCCDALTSAREHPSDALLAALIRIQHIADGAYSILPTPGGTARTYTAPLDMAVAHARRQLDAFAGAQPETVQQDSKKALPPAPKSASQSPSAPLTPPPFPAGLFTTCHRVLTTRLYEPALATAAPAPTDPDALPGEPFLRADSLAKCLDSSRDSLAALLSVPPEHLCRLPLTASAALAFTVATTCRLLLLDAAPDWQPDAARATLDFATTLEGLQDNFARADEWAAENARRRRLGGDGGGGGGGENTRPDQYTSKLGWIRQWYMAKTGQAEQRPAGARAQEGTLMPAAHAEPWPHDVTLDFDFWPDLISMSDMAVQTFSGNTCTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYC9</accession>
    <name>A0A7D5UYC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DHX9</name>
        <name evidence="11" type="ORF">G6M90_00g058380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986822.1">
        <property type="nucleotide sequence ID" value="XM_066130665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYC9"/>
    <dbReference type="GeneID" id="26242826"/>
    <dbReference type="KEGG" id="mbrn:26242826"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="637"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="852" mass="94027" checksum="C0029C3F66F738C6" modified="2021-02-10" version="1">MSAKVNRPVSLTKDEHQHQSVGDWRAVTPCRFFLTGSCTKGTSCPFLHDVKSSNSSDTDSQEARVKSRYTVGSGDSKPICKYYKIGVCKYGAKCIYVHADDGQLPQNAAAEPPEDEDKKDDFTRTIGGAFVQFDAGARVSKIRLPGDFSAARISGLRQNTSKESVRDMLAEKGLHISVDDICTFHMEGSYGATVRSDDASFSKRLCSLVQPGCTWGGSKIIVTSIAAPMPSGHNARRVDCKKVHVSWHKAVKIVWLNFGNGDIARRVSDMFSKGAYRVLDQRVTAAAATRAESVIPSRPARGNHVAWTVVLTDVPAAAQERDILRAITHERNKPHHVEMGAPTYSTDEEEAWAMIRSLLTNIGPLEYCDPPLETNANSRRVKATARFLDEADARRASLELGKMELPFHRKARLTVQMVYSAKFKVAINVFDAVQSRIVAQQTTWKDNISFRAYKPTGPLQRFRVLKIEGELAENVVNAKADLESILAGVVATDNDATLWHSSLKTNGKLFQAIKTLEKELSVTILRDKVKSELRLFGAQRRCEDAQRRLAQLIRMESGSNSSRVIELEPQKFFWACHGGFRTIAGQLGQEKVLFDIISTPKKIIVSGSLEDYDLAVAIMEGRKQVPERVEQAKAHDTAQECSVCWTEADTPVKIKCGHIYCLECFEDSCTKANTTAGEFMILCHGNQGNCRSVMAVEDLQTYLSSAALETVLELSFSSHVKRNPNTFRYCPSPDCDFVYRVSSAARTQNCSNCLRPTCSACHEPHIGMSCAEHQDLKSGGFAALMKLKKKLGIKDCPKCATPLEKVSGCNHMTCAACKAHICWVCLMTFANGPAVYEHMGKLHGGHIDLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYS9</accession>
    <name>A0A7D5UYS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle subunit trs85-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trs85-2</name>
        <name evidence="2" type="ORF">G6M90_00g073170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545745.1">
        <property type="nucleotide sequence ID" value="XM_014690259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYS9"/>
    <dbReference type="GeneID" id="26241778"/>
    <dbReference type="KEGG" id="mbrn:26241778"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="708" mass="79176" checksum="E4C226DB83A46D86" modified="2021-02-10" version="1">MSNPSAASLYASTLSPPSSRPMSPAIQGSSVTISEPVFDAYPGRGISDSVFDKPGEPVHEIIQAFVPNVSVYASDDTEILIKEKGFRNGLWELLRPFGENIQGNVTVRDSHGMSRVFEDFAIRFTKLGENIQNLGSTVSNSQRTLVNTNQKSAPENTERDKVALAQIESVVDRHLSFAEGSIPRPPSPALDTLRQGLDRDSASPYYSLYLRRLLSGTPITPHETFAHPVACVIAISSRNGAPIEELRKLYSESNEGNRKLPLWADNDYLRYYVLVHDEENDDITRSMGFFEQMKRHLGLHCHLLRLRCSKSAETDDDSMPLPCSDWMPAAEELARIHRSEDGEDFEDPTQYIFESDATAIRTFVREMVTQSVIPTMERRISVWNDQVASRRRGITGRFMNLSRKWTGFGSTSRSSSSGSHSRDNFDHLGYYRADSAEAIIRKLADFAFMLRDWKLAHSTYELLRSDFGEAKAWKYHAAANEMAALSLLMTTQISASKTRADSVDQMLESAFYSYNTRCSAPFGAIRCLLLGLELLRAKGGAYVDDASRWGLRLLEARILGPVGDALLKERLCICYLSKLGVGSWGWGSRYRKAAIWSILAAQSWNQQGKYLPAQRCLSECHNIYGFLPHSKGIAQFRTAEEYMHSLRLEVLEKLNLSDAARSDPGREGTPVIDVESQTFTNLPSKRASTISRTGMLETAPLRGEITAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYY2</accession>
    <name>A0A7D5UYY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g058950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    <dbReference type="UniPathway" id="UPA00143"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="586"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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        <location>
            <begin position="535"/>
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        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="GeneID" id="90967950"/>
    <dbReference type="KEGG" id="mbrn:90967950"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="QLI70397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="70" mass="7854" checksum="D705E840780A9330" modified="2021-02-10" version="1">MTSGPARVRVRCFRSVERTTTCKQKSSDHDAVWWLPNCGCTAYKSKLVLFATRPKRCNGSINMAAPYAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZJ1</accession>
    <name>A0A7D5UZJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inner kinetochore subunit wip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wip1</name>
        <name evidence="9" type="ORF">G6M90_00g071890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0000278">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBFA_NFYB_domain"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="9"/>
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        </source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="78" mass="8661" checksum="E38D4AC6D4E5A054" modified="2021-02-10" version="1">MALGKKAYPRATVKKIIKAHSNMSVKKNADVTIFLNYVLFMETLVKEAAIYAKQSGERGLTARSVNKVTRDTLAKFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZM9</accession>
    <name>A0A7D5UZM9_9HYPO</name>
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        <submittedName>
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    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZM9"/>
    <dbReference type="GeneID" id="26246713"/>
    <dbReference type="KEGG" id="mbrn:26246713"/>
    <dbReference type="OrthoDB" id="4939013at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="32548" checksum="13081673A97ED30F" modified="2021-02-10" version="1">MYAGINIFVCGDFHQLPPIGATVMYSNLLNARNADFLAGQQAYRALDTTVRLTQLMRQDGDDEETLQFRRALEELRVYQVSQQSWQLLNTRVQNELTHNEVESFKDALRLYFRREEAHVHNHQRLRDCKQPILRIKSTHTGQGAEGANDNEADGLDPHLCICLGARVMLTENIWVENGLVNGSMGTVRDIVWREGQDATKDMPTAIMVEVDDYEGPKFPGTDYIPIFPVTRRFEYKKRDCSRTNFPLRPAYAITVHKAQGLTLKQVVLNLERKDHAPGLSYIAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V023</accession>
    <name>A0A7D5V023_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">THR4</name>
        <name evidence="16" type="ORF">G6M90_00g071950</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545866.1">
        <property type="nucleotide sequence ID" value="XM_014690380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V023"/>
    <dbReference type="GeneID" id="26241899"/>
    <dbReference type="KEGG" id="mbrn:26241899"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="15">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="104"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI70651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="537" mass="59941" checksum="CED6C74CDE556670" modified="2021-02-10" version="1">MAQNGVSEGSSDFHKPSQRYLSTRGEDSDCSFEEVVLRGLASDGGLYIPEQIPRATAWESWKDLSFSDLAYEIMSLYISQYEIPSPDLRDLVNRSYSTFRSDQVTPLVQLDGNHYLLELFHGPTFAFKDVALQFVGNLFEYFLARKNEGKVGRDRHHLTVVGATSGDTGSAAIYGLRGKKDVSVFIMFPKGRVSPIQELQMTTVLDKNVHNLSIEGTFDDCQDILKSMLADPEANKPINVGAVNSINWARILAQITYYFHSYFSLVKQSPNFKLGDKIRFVVPTGNFGDILAGYFAMRMGLPVEKLVIATNENDILDRFWKTGKYEKQPAPEDGKDIAPEGVKETLSPAMDILVSSNFERLLWFLAYEFASSAGMDDQWNKKQAGQEVSKWLKELKTTGSFGPVYQDVLKCAKRDFDSERVDDNQTLETIQALYKKVGYVLDPHSAVGVAATIRSAANASPDVHHISLSTAHPAKFSSAVEKALNGQDGFDFENKVLPKEFVGLSEKEKRVTEVEGSVSKVRELVKAQVEQELSELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Q9</accession>
    <name>A0A7D5V0Q9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539957.2">
        <property type="nucleotide sequence ID" value="XM_014684471.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Q9"/>
    <dbReference type="GeneID" id="26247177"/>
    <dbReference type="KEGG" id="mbrn:26247177"/>
    <dbReference type="OrthoDB" id="5430319at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="630" mass="70519" checksum="A176B7F61867FA1B" modified="2021-02-10" version="1">MGQQFSKDIRSRLEHQTLEELLINDKCAEEIEQHLLRLPKTSHNNLAKILASWDKAISNNSISKSQSNKPPQDWIPTAKNRNSRSYKLGSLWSIQSQDINIPQKVAEVLKQNPRDVLRQWSKNGVDLQSPSDYYEYTCNVETDRILCRILWRFLTTFYYDLISELDATKNLLHKTENGGVSFVVAVICQSGKHNCDIVRERVVGWAKIGRRYRGFMNALCSGCLFLFPEKISDLVWETYVPVKGSTFAKVTQFLRELGIVCKCEEGGWNDLSDQILQALREPFRNVIPFQFQPDQQSQLRYPSNQPFASAPGDVDVNRREPGPLPKQGANRVIKATRKRGTASVRRKLQSVTGDLAPLQAPRAQNRAHGGDPQRQLPRAPAQFSTPAPNECGQWHLTTNDQIQQPVNIPLKTTEVHNVDEQQGQVESSSDTSRFGRSGINNISSLLNHDSGTSIIGFPVAQNSLPGSPTSLAEPDGVTTGQHSVLPSVSPVTSNVQTTSLGVIQFEKKLLQRLVFDRPTDIMGDIWFGSLPGFVPFVSLRLSEALGDIVKPFGREVFIRSPAPEANRIFEGVYSIKLECFMELIQRDGFGGTFWNETEGRAFVSIEVLDKQLIADFFQACEQAIGGLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0T0</accession>
    <name>A0A7D5V0T0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g067630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540519.1">
        <property type="nucleotide sequence ID" value="XM_014685033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0T0"/>
    <dbReference type="GeneID" id="26246626"/>
    <dbReference type="KEGG" id="mbrn:26246626"/>
    <dbReference type="OrthoDB" id="5279542at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20198" checksum="DDA38AE15013D2C4" modified="2021-02-10" version="1">MEQQQQAQMNPQGPVTYMAAPQPFQHPPQSNRIIITSVHVLVMAMSIIGMGFDFSLVRITGGMYHVSAAVATLLFIMAFFWSLAELIVRGKCNWKAGIHPGVHVVVCLVLSLFAVFIGATLASSAALICPNSDGWCKDKRVSPMVVGSPVLALLLAAVEFILFVVACADTLALIRRQRSAAIASRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Z1</accession>
    <name>A0A7D5V0Z1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sepH</name>
        <name evidence="12" type="ORF">G6M90_00g078730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987223.1">
        <property type="nucleotide sequence ID" value="XM_066131092.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26241268"/>
    <dbReference type="KEGG" id="mbrn:26241268"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000176">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000246">
        <property type="entry name" value="Putative Serine-threonine kinase SepH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1318"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1239"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1256"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1335"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1445" mass="158872" checksum="9C839F01EF25415E" modified="2021-02-10" version="1">MPPERQYHANNGNGRHAGHAAIVATRERSGVPGTPSRKERQRESSAVQDPGLKDYTLGECIGKGAFGSVYKAFNWSTGEAVAVKQIKLVDLPKSELRMIESEIDLLKNLLHDNIVKYIGFVKATDCLNIILEYCENGSLHSILKAYGKFPENLVGVYMTQVLLGLQYLHDQGVIHRDIKGANILTTKDGTVKLADFGVSTSTLAGGQDKEAQVVGTPYWMAPEIIQLSGASSASDIWSVGCTVIELLQGKPPYHNLAAMPALFAIVNDDHPPLPEGISPAARDFLMQCFQKDPNLRVSARKLLRHAWIVGCRRAEAPVSKAPDNFNQAVEEVKQWNKALNSSEPALRSSTGSDTTGISSRFIGGTPGKGSMGLAKPRLGVEAFKTAEQADSDNWDDDFVTAISPSALHLPHLKPQDNFGGLLSSDKLKAFASTNDLRIDTDNYDDDFEGELLTIKGPAHQRDEVQEQTLRPIHKTAVPSTNAKSHQRTKSLGKAIAQVPGSSVPRSPSKGHFGNKFELPPRPDVVFREQSVEDFSDLFVDNDEAFNYRVNRAVRRGSRATDAPQLFHPSDLTTLPRSMQAPDGSIRKRPPSRPSVLPDRPMRRTRSSIEIQKFAEDDDEDFSDVFGASDSIADKEESERGSEDGGLMLLSKMSSNSWLGDDEEEYDPFASMDPGWDEMDLEANIARDRHARLAEKVEDLVSSLKTTEANDTLSEVSEDLLGLLWENKEVKNLIISAHGLLPILEILEPCTVKSRQYMILQLLKVVNAIILDDVEIQENLCFVGGIPIITKFAARQYSDEIRLEAAAFVRQMYQTSTLTLQMFVSAGGLNVLVEFLDEDYDGARDLVLIGVNGIWNVFELQGPTPKNDFCRIFSRSKILYPLALVLHRVLDEEDEDELGELIEGRIVNIFYLFSQAENYVKEVVADRQVLKSVLKDLRRMTPIHQVTMLKFIKNLSMLSTTIETLHSADAIEFLIDLLSYSMKKGQKHFREISNQVLNTLFNLCRLSKERQEDAAVGGIIPLLLRIMQTDRPPKEFALPILCDMAHSGSKGRRYLWQNKGLDFYVSLLTDQYWQVTALDAILVWFQEETANVENHLIDGNFTRAIVSCFSTNKLNAFDSNLLEPLHKLLRLSPSTASSLAKPEMFAGITQRLGHKKPVVRLNLLRLVRIIMDACEPGLGGGDGSRTLNSRQVRSLMDSIQTLAETDSAVLVRNLAAELVKSHIDSSSGMLLLRHDSGVTSASSQVNPASSSRRGPRRNTSYTPPSLQSSISMPQTPTHRSRTSLASNAGAFIEVAASPRRTAAASALERDAIYYRPRSRDSTAGFVPTSIPRRVSGDSTSSMSSSATTGSAGPSSKSRLPRTSLASRPSGAPFSVLRGDPAPPMVVRSDSSASNKENSASGNGYSMASISRPGSSRDGTAATAVASGPKRRQRAPSELKWSNSDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1H5</accession>
    <name>A0A7D5V1H5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IDH1</name>
        <name evidence="14" type="ORF">G6M90_00g092440</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541888.1">
        <property type="nucleotide sequence ID" value="XM_014686402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1H5"/>
    <dbReference type="GeneID" id="26245356"/>
    <dbReference type="KEGG" id="mbrn:26245356"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="59"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="393" mass="42992" checksum="4FDC1487FB0A1F09" modified="2021-02-10" version="1">MEWQPVAAQDTYDRHYIRRAEPLVAILLRSAAGQHQFARSFATVQSDIFKPAKFGGKYTVTLIPGDGIGAEVAESVKTIFKADNVPIEWEQIEVSGIIDGAGRTEDAFRESVASLKRNKLGLKGILHTPISRSGHQSFNVAMRQELDIYASISLIKNIPGYETRHKDVDLCIIRENTEGEYSGLEHQSVPGVVESLKIITRAKSERIAKFAFSFALANGRSKVTCIHKANIMKLADGLFRSTFHNVAKEYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNIGAALVGGPGIVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPTAMILSGSMLLRHLGLDDHANRISKAIYAVIAEGKVRTRDMGGESTTHEFTKAILDKMEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1T3</accession>
    <name>A0A7D5V1T3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="ORF">G6M90_00g088100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542305.1">
        <property type="nucleotide sequence ID" value="XM_014686819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1T3"/>
    <dbReference type="GeneID" id="26244819"/>
    <dbReference type="KEGG" id="mbrn:26244819"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="366" mass="40123" checksum="DCA6706651401673" modified="2021-02-10" version="1">MPSYSDCFVDYVEDKAGRRLGAVGRDTRPQGRPGPRRYLGGLSFGPSSTVMVQLLDICARFYLSKKSSPAFEPLAVHVDTDLSHPADQDDGPAQRLLSKYRQRFPNVSFECVHLSRICAVKTLDWSALGCPHMGEPGGDRVGRLQKYFDSLPSVTSRADILRLFIRHILLDLALERSYSALLLGHSTSALAALTFAEVANGRGFAVPWQINDGPFAVCTYDARPGSTGTKEVSQAQMPVYYPLRELFKNEIKIYLDLVPSLKDLMPEDNATASNVVSHKDLSITEVMERYFDSVEGPQSGIVANVVRTTGKLDRAASGSFCLMCGMTLDKQGDSRWAGELGDDADTHDAASRTAHLCYGCKRSING</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2T6</accession>
    <name>A0A7D5V2T6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g097120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546628.1">
        <property type="nucleotide sequence ID" value="XM_014691142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2T6"/>
    <dbReference type="GeneID" id="26241051"/>
    <dbReference type="KEGG" id="mbrn:26241051"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31287" checksum="346D012202A8851B" modified="2021-02-10" version="1">MGAKSGLALKFLQWFIRGIQFLCAALILGIYAYFLAALHNHNLPIETSVRAVTGISGAAALYTLLGLLLLCCVAGFAFTSFVAIVLDFCFIGCFVYVAVVNKHGAGSCSGYVDTPFGQGQSDATAPGITDGFTALPSFHTACRLQTASMAVAIIAIIFFIFSMLMEVALVRHHRKEKRFGPSPGNNYTSGYARRGFFSRFRRDKDAAPLDEASRLPEHTLPDQLDHTRQSYGTENTAVNHDGPADYYKQEGGYGLQTHGTTGGWHTAPQTSGAPARNYKYEDGIYERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3I9</accession>
    <name>A0A7D5V3I9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g095460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546784.1">
        <property type="nucleotide sequence ID" value="XM_014691298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3I9"/>
    <dbReference type="GeneID" id="26241207"/>
    <dbReference type="KEGG" id="mbrn:26241207"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="428"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="639" mass="68248" checksum="4698528C1C4735ED" modified="2021-02-10" version="1">MSQSQQLPPARRQVGAGTYGPHGGQPDELHMPGMTSSPHGQMGSQKDYTPQIKLDYPPANAHPADQTQPQHHHHHQQSAGSGVPNVLQPGGLSARPTAVTSSTAPTLAAIHGAMPPPSTGPPPSQQNQHGHQQSPASHEYQTPPKPSLSMAHSHTYSLSSPSASYDGPANYHAYTPTTPGGPASQLMSPADAGKYGTPGSQRNFSNTPLGLADIRPRADSSMSDGAPGATGQDISSTQPGPSNYMAPWAVYAFDWCKWPPLGNGAGKLAVGSYLEDGHNFIQILDSQVVPASQDVYSPGTSKYSLEFTKVAEATHSYPVTRLLWEPPSSQKQSTDLLATSGDHLRLWSLPSETQANPSNNITRGGRDASSITKLTPLALLSNSKTPDHTAPLTSLDWNTVSPSLIITSSIDTTCTIWDIPSLTAKTQLIAHDKEVYDVRFCANSVDVFVSCGQDGSVRMFDLRSLEHSTIIYEPTGKEERDGSGRSSPSHSQQTAGSPPPLLRLATSPHDTHLLATFAQDSSTIRILDVRQPGQALLELKGHTGPINCVEWSPLRRGTLASGGDDCQVLIWDLMNSSSSIGGHPLNGAPQQDNHRNPVASWECEYEVGNLGWVPHLQNTDYGEWLGISAGRGIWGTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3P6</accession>
    <name>A0A7D5V3P6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g100290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546320.1">
        <property type="nucleotide sequence ID" value="XM_014690834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3P6"/>
    <dbReference type="GeneID" id="26240743"/>
    <dbReference type="KEGG" id="mbrn:26240743"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="343" mass="37577" checksum="CA40083BFE96BC82" modified="2021-02-10" version="1">MSDKQEVTQTENGPVRGGKKAALKNHCKRFWWLHLIIFLCISAAVICIVIFVGVKNIAQDKINDADLRIQAVNILNSEPDKFTMQINSTITTDGTVKADIDPFVGNLTLRDVPGARPFVQLNFPSTNANKFQTVNISQEVQITDRDAFIEFNKAFFQNETLRVSIHGKTKVQPAGLSKKYDVDFYKVVTFKGLNKLNGTTLTDMKIKIGTAEDGIPNFNATATISNPSYYTIDIGNATFNNYADNQLLGNLTIQNLVLKPGQNVVPVSAILDQTIIISAATKKPYCETGKITIDLQGTHVQQGGNEIPWLMDALGSANQTVELSLAETFQAAGLPDFKATCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3U6</accession>
    <name>A0A7D5V3U6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g102450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546101.1">
        <property type="nucleotide sequence ID" value="XM_014690615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3U6"/>
    <dbReference type="GeneID" id="26240524"/>
    <dbReference type="KEGG" id="mbrn:26240524"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34482" checksum="DDE3808692990C16" modified="2021-02-10" version="1">MEPVPETERMEAFKSSPVPSLRLSSNPNAIPPLDLDMVRKPPTIRRSTDPNPTSPISPSWSSAPSVALPYRPRTASPLSGGHSRSRSAASLASPMSRTQSMPGVSGSGRILYSPGLRPASPSNSSSPSRVRTPRKPVDEAFPATSPVRTSVLEQDKKQPDRSSSPVLGGAIVSSSRLRRSSSPFRSVPPPSSSALSLLPSPPSSVSSASSLRGYDALSASYGGSLSSVPSTPTSARSRSPSISSLETIPDSPDAEEAALEAEKLTQLKVAAEGADGGDSFDSKGRPPMDAPPRGRTLSYGPRDKRKRWSVCGAERRGDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3X5</accession>
    <name>A0A7D5V3X5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g094660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540830.2">
        <property type="nucleotide sequence ID" value="XM_014685344.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3X5"/>
    <dbReference type="GeneID" id="26246443"/>
    <dbReference type="KEGG" id="mbrn:26246443"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI72819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26482" checksum="5E1B073F73898D11" modified="2021-02-10" version="1">MEKLVGYQPGGHHPIHLGDELYNGRFRVIHQLGYGGSSIVWLCRDQGQNNRTKQNTANCNPTPDVPHAPKYMVQQVDFHETTDLGLILPRAVIIDFGQAVKTAGEQPPFGIPTDYAAPEVIWKRSGGREVDTWSLACTLYEVRVGKHLFEVPHLVVLDEDDYEYEISSVIGERMKELGDGSVNTAAAAGQICKRAFGDDVTAEQGQWAEMLAGLLRYEPHQRPKVQELLKNAWFDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V415</accession>
    <name>A0A7D5V415_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anthranilate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trp4</name>
        <name evidence="5" type="ORF">G6M90_00g100780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546271.1">
        <property type="nucleotide sequence ID" value="XM_014690785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V415"/>
    <dbReference type="GeneID" id="26240694"/>
    <dbReference type="KEGG" id="mbrn:26240694"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="3">
        <location>
            <begin position="113"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="416" mass="44677" checksum="101CAF75A38FA61A" modified="2021-02-10" version="1">MASTPTPSGSGSSQPGLPPVDLKPLLTKLWPVNNEVTADEIAEAISHFFTNQVTEAQTAALLMALHFTKLDFRADVLQKTAAVMLEAAEDIPVKELNEVLARRGRKEGAYNGGLCDIVGTGGDSHNTFNVSTTASILASSLLMVSKHGNRASTSKSGSADMLNSMKPRAPVLNAVKSGSLVKVYSVTNYSFLFAPVFHTGMRYVAPVRKQLPFRTIFNNLGPLANPVEDVLEARVIGVGRRDLGPAFAEALKAAGCRKALIVCGEEELDEISCAGGTLCWMLREKSPGGEVAIERFTITPEDFGATPHALSEVSPGKEAAENAEILRQILCGEFPENDPLIDFIAINTAALFVVSGICEADTSDMGHGDDGKVILERGHAGQRWKEGFRRAKWAIKSGQAWKQWHAFVEVTNEIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4G0</accession>
    <name>A0A7D5V4G0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional regulator WAR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WAR1</name>
        <name evidence="10" type="ORF">G6M90_00g098210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546523.1">
        <property type="nucleotide sequence ID" value="XM_014691037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4G0"/>
    <dbReference type="GeneID" id="26240946"/>
    <dbReference type="KEGG" id="mbrn:26240946"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR PBCR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="781"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="890" mass="96832" checksum="394BD14DF294F448" modified="2021-02-10" version="1">MDLDPRLRLDHGGQRSPLLSGAVSRGKSTSTPSPSSQVETASTVAQHRPAPYHVTESSDSPPADLGTPNQQQNPHGDGTDHDGGAAGGAAGNDAKKSRACEACRGLKVRCEPDPDDEGAPCKRCKKAGRSCVVTVPTRKRQKKTDSRVSELEKKIDALTASLQARAAVPAIGGGGGGDAAAAGQGISMAGIAASSATAPRRKSSEGMSGLWINSDAARTWAGSETGAAAQGIVASPVQQSHTPRSYRPSVFDPPEMVAGHKRKATEHRDGSGEGSPAASSSQWPMARRGNRTDIIDRGLVSLEAAAELFQRYKEHMLKHLPAVVFPPTMPVMELRRSKPYLFLAVMAAASSETHGLQRVLQRELMELFAEKIVIVGEKNLELIQALHIAVIWYWPPEHFEELKFYQLVHMSAVMALDIGLGKKSAPKRGITGFSWREHPFRRHPQPDPTSLECRRTWLTCHFLAANTAMSLHRPNLIRWSPFMTESLDMLSTSPDAYPTDRYLCHLIWTHRMAEDIGVQLSMDDPDTAVNIMDARTQYTLRGLERDLDKYIATVPKEMMQHDASATLKMSFSILNLYMHELALHSDNTADAIRPPFATDMLQDGMVSSEPLSAAHINALSACLSAIDNIFQTFLAMDVFSIRCLPVFTFVRVAYAVVILMKMYFSASSPSSELGKVINKDNMRVAYYLEALLEKFSATAADDKCRPASKFLLVLVMLRTWFLKHGKADTRQDAQNPLPAAGSSSNTPADGGTPSMQPSQPLPEHAANTPLQVLSEVAMGRESNTPRPFYNSISGGQAPPQNAYYAEGTNTPPQVRDPPAFPQPWMAQPPQPSVDMDMTVGLPANFDFESLGVPLDQSGDMYGGGAKMAVLNDPLFSDMFQGLPDPNFFSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4G8</accession>
    <name>A0A7D5V4G8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tubulin-specific chaperone E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TBCE</name>
        <name evidence="7" type="ORF">G6M90_00g102310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546115.1">
        <property type="nucleotide sequence ID" value="XM_014690629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4G8"/>
    <dbReference type="GeneID" id="26240538"/>
    <dbReference type="KEGG" id="mbrn:26240538"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="6">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="574" mass="63386" checksum="B22AF656F807AB26" modified="2021-02-10" version="1">MNQEPHVGQRVSYGGALCTVRYVGEVAGTTGSWLGVEWDDSTRGKHDGSHKGVRYFTCLSRSSTAASFVRPTRPKDDVQGFLSALKEKYLSDPEQDKHGQPGAQIVISGRKVAEEVGFDKIWKKLAQVEDLKIVILDGMRMAVSRQDGDGPIAESCPSIVHVDLSRNLFETIGPVVDICAELKTLRKLSINGNRFQNLLQDAALDRINSAFQGVTELSLEETLLTWEEFCAIAARCPSLKELNAGSNQLTCLPKMGHLPLPPALTSINLEFNEFTALSDLASLTSLTSLRNLHLKGNNITAISSHGATGPVFPPSLQYLDISYNSISAWSFVDLLPTHFPGLNALRLSHNPVYDAAKDDDKKASSSEESHMFTIGRLANLQSLNFAQVKAADRTNAEMFYLSRIAKQLATVPESAEHTILVQHPRYKELCDIYGEPDVIRRDEVNPSFLEARLISVTFHFEGGQTKTCRIPRSFDVYAVKGIAGKLFDLPPLRVKLVWETGEWDPMAGYDDRDGDSSDDEELRGDETAEKAQEIGGMNGKSGRWIEREVELKDGPKQLGYCVDGLDVSIRIEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5A8</accession>
    <name>A0A7D5V5A8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pre-mRNA-splicing factor clf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">clf1</name>
        <name evidence="13" type="ORF">G6M90_00g109290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543925.1">
        <property type="nucleotide sequence ID" value="XM_014688439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5A8"/>
    <dbReference type="GeneID" id="26243312"/>
    <dbReference type="KEGG" id="mbrn:26243312"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="12">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="326"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI74717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="672" mass="80456" checksum="FD66268436B885E3" modified="2021-02-10" version="1">MESSRGPPRVKNKAAAPVQISAEQLLREAVDRQEVGIQAPTQKFSDLEELHEYQGRKRKDFEDYVRRNRINLKNWTQYAQWELEQKEFARARSVFERALDVLPHNVVLWIRYIEAEMKSRNINHARNLLDRAVTILPRVDKLWYKYVYMEEMLGNIPGTRQVFDRWMQWQPDEAAWSAYIKLEKRYGEFERARAIFENFTTVHPEPRNWIKWAKFEEEYGTSELVREVFGNAVETLGDDFVDERLFIAYARFESKLKEYERARAIYKYALDRLSRSKSKLLHKAYTTFEKQFGDKDGVEDVVLSKRRVYYEEQVKENSKNYDAWFDYAGLEESSRDADRIRDVYERAVAQVPPTQEKRHWRRYIYLWIFYAVWEELEGQDMERARQIYSTCLSLIPHKKFTFAKVWLLAAQFEVRQGQLTAARKLLGRAIGMCPKDKIFNGYIDIERKLFEFVRCRTLYEKHIEFNPANCQTWIKFAELERGLDDLDRTRAIFELAVGQQQLDMPELLWKAYIDFEEEEGEYERTRELYERLLEKTDHVKVWISYAHFEINIPEDEEGAEEQPLSEEAKARARNVFERAHKSMRDKDLKEERVSLLNAWLSFEREHGSDEDVDKVQRQMPRRTKKRRLLEDDTYEEYFDYVFPADDQQAKNLSNIMAMAQKWKQTGGDLSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5B8</accession>
    <name>A0A7D5V5B8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Core trichothecene cluster (CTC) protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRI15_1</name>
        <name evidence="4" type="ORF">G6M90_00g111470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543717.1">
        <property type="nucleotide sequence ID" value="XM_014688231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5B8"/>
    <dbReference type="GeneID" id="26243104"/>
    <dbReference type="KEGG" id="mbrn:26243104"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="340" mass="38212" checksum="473A907AEB81314E" modified="2021-02-10" version="1">MDKGVFNCRTCNVEFSSSQTWRAHAKSDTHVANLKDRVTSSGVVLPSTMAREDEWNNHGSRPAQKSQDIKLSFNRPTTESDESDDELASGGNSDTESDMAPTFVPDQCLFCGTLCGTFEQNLSHMSKAHSFIIPNQDSLIVDVETLIWYLHLVIYGYQECLVCSKTRRSVEGIQQHMMAKAHCRLEINDDIRDFYEFSEAPKPEDMIISGESTMKLPSGKILGQRTLPSESLSRRAPARSEPQVPTQSDRSMAKPGSELTTRNDRTLARVATQLSQFRAGDQQSLSHLPAYELRSVLASRMKQLSAAKRVERRMQNRLQTRGNKTLMKHFQPDVPGRQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YL23</accession>
    <name>A0A7D5YL23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g014170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549105.1">
        <property type="nucleotide sequence ID" value="XM_014693619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YL23"/>
    <dbReference type="GeneID" id="26238549"/>
    <dbReference type="KEGG" id="mbrn:26238549"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="290" mass="31267" checksum="B791F6F23B2E363A" modified="2021-02-10" version="1">MAAAATRLVVCGGSGFLGSRICKYAVARGWEVTSISRSGEPKWDSVTSSPLPPSWSHKVSWERGDILRPVTYAPLLKGADYVVHSMGILLEADYKGIVSGKESPLTGLQKMFSPVRERGTNPLDKKAGEDIKPPNPTDQFSYEVMNRDSAVALAKHAAAEKASAFCFISAAGGAPIMPPRYISTKRQAEVAIATNFPEMRGVFVRPPFMYDSSRKITMGMAAMAGAGTLFTRMTGNYLKDFMGAAGTKPLQVDTVAEAVVEALSDETVKGPVEVPQIEELANKGWRKTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMT5</accession>
    <name>A0A7D5YMT5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nitrogen assimilation transcription factor nit-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nit-4_1</name>
        <name evidence="11" type="ORF">G6M90_00g025770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMT5"/>
    <dbReference type="GeneID" id="26237450"/>
    <dbReference type="KEGG" id="mbrn:26237450"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="688" mass="76997" checksum="C36FCFC3DB9EF984" modified="2021-02-10" version="1">MSSAKATKKSAFSCEPCRRRKVKCGGEQPICQRCAARNDECIYKLNPTLSYTQRLEGRIKELEDQVANLTKSPPSLAGSSHSSPPVSGVQDVSSQTSRHASDEQGISRSFRSLKIDDKGSITYHGATSFFNLPSDRTGPGPSDMPFLNPSSSDTDLQRRERLIHNAWHQRAMENLNEVPEPFQYLLNVHWCWIQPLFNFIYRPVFTRDMQSMGPYYSHTLLNAVISHSIRWGRSDPSTKRLLDDSYHGGLVFGKHARSMLFEELNNGVCTIPTIQTLLLLSAQECSQGNSTQAWTYSGIAFRLLDHLGICVDSQRFPGPVPLGDEELEIRRRIYWGCYFWDKLICLYLGRSPSLQHTNISPSHIMFDDSAENDLWVPFGIPQTDPTWKYPPTTAHSASCFMSMCRLAVIFNEILIHMYDPLSQNTDAEIQECLNSQEPLLHQWWDQLPVHLKINPISLPNLAPPSHIVTLNCLYHAFKILLFRPMITGRGQRECEGPSPVQRYLVESVTSATSIMAIFDLFCRTFTINYCVLSLAYCVYIASSIFLLQVQAAPDDQQAMRKLTYCIQCLQQVRQISPVIASALNNINKELTAVGITVGSSMQQSPQAQPSLSTGSSAPLPSGTYQTSADIGRQIPIPSHPVYQPSFSHNFGPDAMSMEPGVFEAMSTLEPLSIRVGTIPESENPPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPG9</accession>
    <name>A0A7D5YPG9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinesin-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">klp5</name>
        <name evidence="9" type="ORF">G6M90_00g028300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541331.1">
        <property type="nucleotide sequence ID" value="XM_014685845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPG9"/>
    <dbReference type="GeneID" id="26245966"/>
    <dbReference type="KEGG" id="mbrn:26245966"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="8"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="931"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="733"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113590" checksum="EDD14F8406833312" modified="2021-02-10" version="1">MAAAGQSSITVAVRVRPFTIREAAQLQKTDDSPVFLGDGSLAGPAPKLHQRGLRSVIKVVDDRCLVFDPPEDNPVQRFSRSVVPTSKKVKDQVFAFDRVFDENTTQSDVYEGTTKNLLDSVLDGYNATVFAYGATGCGKTHTITGTAQHPGIIFLTMQELFEKIDERSQEKSTELSLSYLEIYNETIRDLLVPGGSQGGLMLREDSNQAVTVFGLTSHHPKNVQEVMDMIIQGNEYRTVSPTEANATSSRSHAVLQINISQKDRNADVNEPHTMATLSIIDLAGSERASVTKNRGVRLTEGANINKSLLALGSCINALCDKRQRAHVPYRNSKLTRLLKFSLGGNCKTVMIVCVSPSSAHFDETQNTLRYANRAKNIQTKVTRNVFNVNRHVKDFLVKIDEQMALINELKAQQKDAEQLFFAKFRKQCDKRDGVAREGVLRLRAAYDHSAAERQERIATMKKLKAFERRIAMLTGWIAAFDTVCEQRADNDSMPQNLISIRKTAQGIQVELENSRQHIHQKLEKATWERAIDTALSHSLQQLEGLEGIDSGEHATLTREAELLKANFGREAYREVLEQEKLGDAAMMQMLLTAQFEMLASLSDTLAMDEESAVAQAKQIIHKLLDTGYTAAGQVVKPDGSLPVLEIFPPTRKGTPKRKKSLGAYVKPIAPLALAAVQSEHVFASPMKSSPRRRKVLGTAKKGISFTPVKKSKPRSVRWRDDESEDGTLADFANTPQQMDATPDQSSAERTPIPPPQPTYLVEDEQNRETSSPRIEAPEEEQAATPASKPGRFQAGFLSKTRMSVQPQGSPLLQAPMLSRSVSSSSPNSGRLSPLRTLDVSKTGNLSPPSLPAAHRSRLSPPQPTSLRGIVDENNPPIQGTPSSGSDSESSMIDVRKLRSAIQSAKARRPSALGGVVAANGRRVSSISTIPERAMPRPSMPSALASSTNGISRARRGSLERRKSPPLTCSPPEFKGDRNLTAGQARRMNLGGSVRLESTASSPRDGLKEAPRRVTISVGSTPASHRRQETRGATAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPY2</accession>
    <name>A0A7D5YPY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g028950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541272.1">
        <property type="nucleotide sequence ID" value="XM_014685786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPY2"/>
    <dbReference type="GeneID" id="26245907"/>
    <dbReference type="KEGG" id="mbrn:26245907"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028948812" description="Aminoglycoside phosphotransferase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="310" mass="35387" checksum="B64FF5F4BB6CCA9D" modified="2021-02-10" version="1">MGQSIGSLFPLRWRLWLGKLLFPPLGPSTYRVSWHRVIKGPCDPTEVEAMNYVAAHTTVPVPKIYAVHNEGHFTYIEMEFICGETLEEAWEHLSKGQMMAIFDDLKNHLSSLRALQPPKQGMVSSALQNPAFDCRIGFRFFGPVSHDGFHSLTRGHLIMEDVEPFLGPEVAKTHTGSYATYFTHADLAPRNIMVRNGRIIAIIDWAFAGWYPEYWEYTKVHYNMFMGQDVWVEYMRLILPGYETELAAERILWRRLPEPGTISGTFSNPHVHTKGSTPSAEWLRKRAGLKSKDLWSLALARGNYDTTVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQR2</accession>
    <name>A0A7D5YQR2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sexual differentiation process protein isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">isp4_5</name>
        <name evidence="10" type="ORF">G6M90_00g040670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547415.1">
        <property type="nucleotide sequence ID" value="XM_014691929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQR2"/>
    <dbReference type="GeneID" id="26239978"/>
    <dbReference type="KEGG" id="mbrn:26239978"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="876" mass="99889" checksum="6EE2AD851919875E" modified="2021-02-10" version="1">MEKSETKEKPSQVLEKTEAFDTVHHTISEEDAERTHTVEGHLNATEDDILEAKELAASMSLEHVRRLMKNVLAIHDGDPNFPHVTLQKIKEFMDNPAIMEHPEKHERLVQEMKLEAALITNNSPYAEVRAVTDNHDDPSMPVSTIRAWTIGIAFSCLLAFVNQLFSIRQPPIRFDTNMAQLLAYPVGKAWEKWMPKKEMRVPFTSQIINLNPGRFNKKEHMLIAIMANTARSLPYTQYIIWTQVLPQYFNQQYARSFSYIFLNGFATNFIGYGLAGLTRKFLVYPSYCVWPRSLVTIALNTALHNEENHSVQGPFGKIWNISRYRFFMVSFAAMFVYFWFPNYLFQVLTYFSWMTWIAPDNVHLNILTGMQNGLGLFNPLPTFDWNVINFNETDPLMIPSFSTFNFAGGMFITGLFILGVWYTNTWNTAYLPINSNRIYDHFGKLYNVSRTLDNRGMFDLDKYSKYSAPYMSAANSLLYGFFFAIYAAVITHVILYHRYELKMGFKNLVKGLRWRRNKKESEGEQGNERAMDGEYLDVHNRLMAAYPEVSEWYYFLTLIISIVFGVLGIALWPTYTSPAVVLYGIWLCLMFVVPVGIVAAMTGIEVTLNVLAEFIGGMIVEGNALAMNFFKSYGYVTCAHALSFANDLKLAHYVKIPPRVTFAAQMIATFISTLICTGIIKFQMEISGVCTLNPPMRFRCPGPNTFFTASVLWGTIGPIKVFGKDGQYKWLLLGFPMGIALVLAFFGLKKLWPNNRALRQIHLVAAIAGGLQWAPYSFSYAFPAVPVAWFSWIYIRGRYLDFWSKYNFVLSAAWSAGIAISAIIMLFSVQWVGAEIEWWGNTQPSAGCEGTACTLKSLAPGERFYPWWDASKVPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR08</accession>
    <name>A0A7D5YR08_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g060000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544569.1">
        <property type="nucleotide sequence ID" value="XM_014689083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR08"/>
    <dbReference type="GeneID" id="26242981"/>
    <dbReference type="KEGG" id="mbrn:26242981"/>
    <dbReference type="OrthoDB" id="5411518at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="379" mass="41960" checksum="AC61022256192513" modified="2021-02-10" version="1">MSRPSRVQARCVGNPSFRPEDIAQNQDRLKQARDLLSKNDLYQASRMLLGLPEPDVYTYHAIASVKLAEAQHVVDRGGDNGLHGWYKAEDGSTRDPPSQADIEAYISIFSPTTSTAAALKNFTTNAKKGSLRSETAAHISRNKFIHASLLTQLTIPKCKSPPIQNPYFDFWAWSCRNLEWCGPNACSERTSMGHHILPIFMHHFGCVTPSHEGLEALRILADGRPIADVGSGNGYWSFMLRGYGLTVHAVDNMQSEWRVNWVDDTSITDGVKWLQRNNGGRDMVLLLVYPVVGGGVGGGTEGSFTRGLVGAYEGDTIAVVGTQNRNGYTGFKSMTMDEYMARERKDWVKVVQMPLPSFAGKDEALFVFQRGERAPKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR36</accession>
    <name>A0A7D5YR36_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RNY1-A</name>
        <name evidence="6" type="ORF">G6M90_00g024000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986123.1">
        <property type="nucleotide sequence ID" value="XM_066129927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR36"/>
    <dbReference type="GeneID" id="90967517"/>
    <dbReference type="KEGG" id="mbrn:90967517"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028952666" description="ribonuclease T2" evidence="5">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="36243" checksum="F55A945839D4C2BD" modified="2021-02-10" version="1">MRRACLVLGLASLAEVAVAGLYPGITPDNHTCALVEPVLSCSCKAKLDKVEDTCCVETFGGLLVATQLWSTFTGLEDKGQIYPKNDWSIHGLWPDFCNGSYTQYCDLSRQYDPKPSPNTTNGQPGGIPVPAYKGEPIETWFGPYGKLDLLAYMNKYWVSQLDPNWVFWAHEFSKHATCFSTFQKECYGPKAAEHDDLFDFFETVVTWQRRLPSFRWLSDAGIRPSNRTSYTLSDIRHALTKEFGQQPFIGCGGPKYNETEAGKGSKDNGRTEINELWYFYHVNGTPQRGDAEKLDAGKAGGRLTTCAQAKGAIKYYERTKGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT11</accession>
    <name>A0A7D5YT11_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g021900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548361.1">
        <property type="nucleotide sequence ID" value="XM_014692875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT11"/>
    <dbReference type="GeneID" id="26237805"/>
    <dbReference type="KEGG" id="mbrn:26237805"/>
    <dbReference type="OrthoDB" id="4850431at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17941" checksum="BAD4058BEF7F8493" modified="2021-02-10" version="1">MSPLTDAGDVLRDAAHLAADQEVSRGRKRSRSTSRAATSKSLRPDESSTLRGRSPRRATSPFPLPSRNTSPSILRSPTSQILLYNQLRRARREHCPSRTASPSDRSFRRRQRTRSRSRSRSRGSRRDHEPVRSPDILSSLRHEVFYEHADGTDNKAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTG6</accession>
    <name>A0A7D5YTG6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g024130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548167.1">
        <property type="nucleotide sequence ID" value="XM_014692681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTG6"/>
    <dbReference type="GeneID" id="26237611"/>
    <dbReference type="KEGG" id="mbrn:26237611"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="446" mass="51787" checksum="079D0241ADDEF866" modified="2021-02-10" version="1">MAHQAHNIPWQALTSHLKPVFRKYDGADGDKTSNFYVCYKPQQGRQLTYFVTAFAQNIEQHTECERRKYQDTYTAPARHDLILTDAVAKKLAPTVLRLRQRSLADSNGRDRYTDQPFDQSMSNDATRLFCRHGDGQPGFGCGCVIPYCERQAAAFLREYVPNPCFQFFQHNAEAFYNLEILKLLLLYGEMDPILRICAHPEVDYENWHHVGPCYDEFPDVGWDRIYVNALDAYLCLNIVYCFPEIWEPASGRTARQDYRNTYMYQRVMASCTSFRATSEVPALPHRQFFGVSNDETYRKRRGDVSWERCKPGHGILPWKEFLAEERLTPDPVVESFAINYACKMLMDKGLPAELVSSILDYVDHATQNRLEKPLDPFHPVNGHQLRRYLAYCWQLIIRCSMLAHALGMNLDWKAIVSERLVELVSRGDGKWCTYRIDSEGDYWGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU27</accession>
    <name>A0A7D5YU27_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fma1_1</name>
        <name evidence="10" type="ORF">G6M90_00g057760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="7"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544357.1">
        <property type="nucleotide sequence ID" value="XM_014688871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU27"/>
    <dbReference type="GeneID" id="26242769"/>
    <dbReference type="KEGG" id="mbrn:26242769"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="9">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="29061" checksum="27E5BC0B0C457C34" modified="2021-02-10" version="1">MRKGCRLAREVLDIAAAAAKPGVTTDYIDEVVHKACIERSSYPSPLNYNHFPKSCCTSVNEVICHGIPDQRILIDGDILNIDISLFHEGYHADLNETYYIGDRAKADPDNVRVVEAARECLEEAIKAVKPGVLIREFGNIIEKHAKKKNCSVIRTYCGHGINKLFHCAPNVPHYAKNKAIGECKPGMTFTIEPMIALGKYRDITWPDNWTSTTIDGKRTAQFEHTLLVTEDGVEILTARRDDSPGGALPMPMPEVSNGKAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWC7</accession>
    <name>A0A7D5YWC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cnp3_1</name>
        <name evidence="9" type="ORF">G6M90_00g099820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI74000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546367.1">
        <property type="nucleotide sequence ID" value="XM_014690881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWC7"/>
    <dbReference type="GeneID" id="26240790"/>
    <dbReference type="KEGG" id="mbrn:26240790"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="214" mass="23793" checksum="9B9885F718E3029E" modified="2021-02-10" version="1">MDSITHQISEYARRVEHTEEPLVGQDVPLTEYQLVIRGGPTSQPETESKSNGNVEPAAHDQDLDAWETNEGTVRASVVVWQPSYQLQLWPPIEAIEVDIADEQIAISASAIETWEIPGATFSYAKTLHTPYMGAGVVDIPPGGEKRTKNARMMQMVFFVHYGKVLVTVHQTRFRISTGGIWTVPRGNYYGIVNDGEGPARIFFSQACETMPETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWH7</accession>
    <name>A0A7D5YWH7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g007650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549745.1">
        <property type="nucleotide sequence ID" value="XM_014694259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWH7"/>
    <dbReference type="GeneID" id="26239189"/>
    <dbReference type="KEGG" id="mbrn:26239189"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="66263" checksum="002457E1710B05EB" modified="2021-02-10" version="1">MTDRGNPAKAQTYLTSSSLSTLSHESASNAARPRNRRVETIDETYNPPTTTGITKSSGTSYPIQGATHGNKTVPLTLERSQEDQIPNQGSTGGDLAQFLGDSWTQSWTSVQAFASTLISGVDNSPKAIRSTHLYPRTPRGSRSETWGPSPPSGGQRNNDVGVGSLAKRRDALKAAKTASILESHEGVNGGLDVIGKHKRRTSDEIRPLDPEPEEHLVYVHNVEPSDTYAGIILRYKCREDIFRKSNGLWSRDSVQMRKWLIIPVDACEIKGRPCDPPSWSDEREADLLTRNSSIARESSFATDGSYRGTLSLSADSSHIDAKQERAEDLPWSHVRWVHIDSFRQPVEIVRVARQALGYFPPRRKKSIRTASPISTPRQSSDLSSLAPNSTERPSTHRLSSVSGHPLIPGTPMSSQSRAGSEATNSRPAWMRRPGGVGSMSRTVRAPGPDTDYFNSWTRKHIPGLDMEALPSMSVMGSETANFGFGQSASGIVESPFENCRNASSTSRQGTGLDRAAAAVEHWLRGALAKRPSTPLLGSRLRPTGLSADPDATDLIELTDTASDDGKAARPVSTSILGSGHSVTTGRTDGGLRIKGRNKFGVDDRATHKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWI2</accession>
    <name>A0A7D5YWI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="8">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">PAN3</name>
        <name evidence="12" type="ORF">G6M90_00g084220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543638.2">
        <property type="nucleotide sequence ID" value="XM_014688152.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWI2"/>
    <dbReference type="GeneID" id="26243815"/>
    <dbReference type="KEGG" id="mbrn:26243815"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="8">
        <location>
            <begin position="553"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="412"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="652" mass="72385" checksum="555D87FE00A241C0" modified="2021-02-10" version="1">MAASRFATSDLRRPAGSASSPKPKGRAENRDTLCRNVLIYGHCRYEDQGCTFSHDQNKNNSNPPDMSRKALNVESPSFTPANLQSAGKKPTFSTQAANAPAFTPRGLGASPALSATPADPESAIFNPAAIREFTPSFELNSQGVSNGSNQDGPVNYDPFAMASVGQGLPSAHFNPYADDHSAMAGAAGGFYQPTGAFAAPLQPLQHHLYAPVGPYREDLMPYHRLTHDFFIPEKLREDLQRKAEASLQVMPNSQLPQMENYHSLVPLDTSHRKNTNVFSYPSWVYKATSSKTGNLYCLRRLEGFRLTNEHAIRSVKDWRKIDNANIVTIHDAFTARAFGDSSLIFVQDYHPLAKTLAEVHLSTGAGAPSPGNRFQAKSPVSEAVLWGYIAQIANALKSIHSINLAARCIDVTKIILTGKNRIRLNACSILDVVQFDMRRPVPELQQDDFMQFGRTILSLATNTPPAQLTNLKASIELMARSYSVELRDTIIWLLTPAQPPSQKTIEEFIRGIAGHIVTTLDQSQHQSDDLNSELYRELENGRIARLLLKLGCINERQELEGDRAWSENGERYMLKLFRDYVFHQVDASGNPVLDMGHMLRCLNRLDAGTDERICLTSRDEQTSFIVSYKELKKQLGNAFGELQKTSKQSRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX39</accession>
    <name>A0A7D5YX39_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dibenzothiophene desulfurization enzyme C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">soxC</name>
        <name evidence="5" type="ORF">G6M90_00g085370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541094.1">
        <property type="nucleotide sequence ID" value="XM_014685608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX39"/>
    <dbReference type="GeneID" id="26246083"/>
    <dbReference type="KEGG" id="mbrn:26246083"/>
    <dbReference type="OrthoDB" id="5356974at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008470">
        <property type="term" value="F:3-methylbutanoyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000020">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase YdbM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000025">
        <property type="entry name" value="Related to Dibenzothiophene desulfurization enzyme C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="3">
        <location>
            <begin position="48"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="266"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="435" mass="47697" checksum="A206DF6E3D7F5979" modified="2021-02-10" version="1">MSAQLTSNAAARIATDPTVYDEYRSTWAEQPKNDGEWIQRAKDVAVVLAADAVQRDRENKSPRAEIALLKHSGLLKVLGSQRYGGGEQPWSVGNQVIREVARGDGSIGMLLGYHLLWSTIARVVGSPAQAERFEELIIANNYFVGGAVNPRDNDLTITRDGDELVFEGFKFFNTGGVVSDLTVLEGSYEGTSDHIFTVVKTDQPAIVFSHDWDNIGLRLTESGSVRINKVRVPWSDALGWDPVAKRPNASDLGVPFATLLLPTIQLVFSNLYLGIAWGALDTATAYTKKSTRAWPFGGDVKENASDEFYILSTYGNFLAHLRAATALADRAGHELTRVYGKASNLSDKNVVSAEDRGEVAEWVASIKVVATDVGLRVTSGVFEATGAKATASKVGLDRFWRDIRTHTLHDPVAYKNRELGRYHLVGEHPTPTWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXJ7</accession>
    <name>A0A7D5YXJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxylase B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gloB2_0</name>
        <name evidence="4" type="ORF">G6M90_00g016630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548867.1">
        <property type="nucleotide sequence ID" value="XM_014693381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXJ7"/>
    <dbReference type="GeneID" id="26238311"/>
    <dbReference type="KEGG" id="mbrn:26238311"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="314" mass="35367" checksum="4DAC44EAC39852FA" modified="2021-02-10" version="1">MRQFSSAQSAENTATPDASFQPIIHDVFEEKTGTWQYVVADPNTLTATIIDSVLDYDPLARTISTHSADKILLLIKRMGYRVDSILETHIHADHLTAARYLQTSLHKEQGYLPLITVGKRIVHIQELFRQKYGLSEEETRGVFDRFLDDDERFHIGSLEAQAIHLPGHTPDHMGFKIGDNVFCGDSVFHADIGSARCDFPGGSAEDLYASARKLLSFPDHVKIWTGHDYPSQSRSEPVPYLSVGGHRAQNKHLMDGYSKDEFVALRRERDSKLAEPRLLHQSLQMNIRAGSLPRPSPEGDRMLHTPLDVKQLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXL4</accession>
    <name>A0A7D5YXL4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ECHS1</name>
        <name evidence="8" type="ORF">G6M90_00g014950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549029.1">
        <property type="nucleotide sequence ID" value="XM_014693543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXL4"/>
    <dbReference type="GeneID" id="26238473"/>
    <dbReference type="KEGG" id="mbrn:26238473"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="290" mass="31571" checksum="B52F7D8438726B57" modified="2021-02-10" version="1">MNTVRFVRPIAARVPFQRSTLPRVVRAYSSKSFEYIQTSTPKPGVGQVTLNRPKALNALCTPLINELNEALNEFNASDETSVIVLTGSERAFAAGADIKEMAPLTFSEAYTKSFIESWSLLTTQIKKPIIAAVSGHALGGGCELAMMCDLIYCTEKANFGQPEIKLGTIPGAGGSQRLTRAIGKSKAMELILTGKSFSGAEAERWGVAARTFPTYEALMEETLKTAETIAGYSKVAVQACKEVVNKSQDLGLRDGVEFERRVFHSLFGSQDQKIGMKAFAEKTKAEWTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYK2</accession>
    <name>A0A7D5YYK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ICL1</name>
        <name evidence="14" type="ORF">G6M90_00g103750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545976.1">
        <property type="nucleotide sequence ID" value="XM_014690490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYK2"/>
    <dbReference type="GeneID" id="26240399"/>
    <dbReference type="KEGG" id="mbrn:26240399"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="432"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI73061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="546" mass="59912" checksum="845DD68679E93C46" modified="2021-02-10" version="1">MAANNMVNPAVNADVEDELFAKEVAQVKSWWADSRWRYTKRPFTAEQIVSKRGHLKIEYPSNTQAKKLWKILEDRFKNKDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASASDEPGPDLADYPYTTVPNKVGHLFMAQLFHDRKQRQERLSTPRAQRGQAANVDYLRPIIADADTGHGGLTAVMKLTKLFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPTSEHISRLVAIRAQADIMGTDLIAVARTDAEAATLITTTIDPRDHAFILGSTNPSLQPLNDLMTAAEKAGKTGDALQQIEDEWLAAAKLMRFDEAVLAAIAASASPDKTGLERQYLAQARGKSNGEARAVARGLLGADVFFDWDAPRTREGYHRLRGGCACAVARAVAYGPFCDAVWMESKLPDFAQAKEFADGVHAARPEQKLAYNLSPSFNWKAAMPRADQETYIRRLAQLGYCWQFITLAGLHTTALISDQFARAYAAHGMRAYGELVQEPEMDGGVDVVKHQKWSGASYVDELQKMVTGGVSSTAAMGKGVTEDQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ31</accession>
    <name>A0A7D5YZ31_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540780.1">
        <property type="nucleotide sequence ID" value="XM_014685294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ31"/>
    <dbReference type="GeneID" id="26246393"/>
    <dbReference type="KEGG" id="mbrn:26246393"/>
    <dbReference type="OrthoDB" id="10505578at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="280" mass="28592" checksum="8956196B1F352E88" modified="2021-02-10" version="1">MSIALAVQGIQAAPAVRNNNIERRDSVIQRAQNLPVSYPGGYKKRDNSRPSDNSVNKKDKPTLAAESTSSSGSDNGSTAPAAKPPSNPGSNIDNKTPPGEFPDCSDSTSGNIAPAKKPSKNPVTDQDGTKLPLNGADNSGSEKGSTGSATEPSKNSGGDKGIKASASKSPNNSVADKDNAKSPLNGADNSGSANGSTGPATEASKKPGSDKSSTALAAKPTNDCDQTGNKSPTPNRFNDSGSKGDGTTAQARPTSVPEADVDPRPDEFSDQEKATDIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ69</accession>
    <name>A0A7D5YZ69_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g099950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546354.1">
        <property type="nucleotide sequence ID" value="XM_014690868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ69"/>
    <dbReference type="GeneID" id="26240777"/>
    <dbReference type="KEGG" id="mbrn:26240777"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="40250" checksum="FBA335840784C2F0" modified="2021-02-10" version="1">MPAPPPPPPPPPPPGGAPAGRPPASGNRNALLSDIQKGRSLKKAVTNDRSAPDVGKTSSGGGPVLGGAPAVPGGLAPPVPGNRARSNSDQGSGQTASSGMESAAPQLGGLFAAGMPKLKKRGGIDTGANSDASYLSDPGESRSAPKPPGAPKPPSGAAPAIPGRGPPILPPSAAGHLRKITPLGGSKPPPPPIGKKPPPLPTSRKPSSKAIPPAAPAPTPPPPPPPASAAPTPSAPPPPPPPALSAASPAAPPPPPPASAPLRPSGSPAPRTQAPHPPPPPPPANSAPIPTHSPSSAPPPPPPNAAPSPPTSQSPPPPPLSRNRGPSLIQSMLDPSSYTLSANGGGSPSPSRNPSHSPSPSIGGRFIVNDSRWQFKDESLLPKPRDFRGGPKKYRAGRGSSVPLDLNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZA3</accession>
    <name>A0A7D5YZA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g101570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987696.1">
        <property type="nucleotide sequence ID" value="XM_066131592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZA3"/>
    <dbReference type="GeneID" id="26240611"/>
    <dbReference type="KEGG" id="mbrn:26240611"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI73581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="196" mass="21666" checksum="99CDFEA37340A172" modified="2021-02-10" version="1">MSPGMTLFSVQAVLILGTEDGARILAKYYSSPHSTTGNTATSSNPYPDLKAQKAFEKGLIEKTAKQTGDIILYDNRIVLYKLESDIMIYVVGSLEENEILLYNTVLAIRDSLHLVFKQSVDKRTIIENYDLVSLAIDEIVDDGIILETDPTIIVQRVSRAPAQDVPIGRIDLSEQGVNNLAQLGKSKLADWLRQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0E3</accession>
    <name>A0A7D5Z0E3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acriflavine sensitivity control protein acr-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">acr-2_0</name>
        <name evidence="4" type="ORF">G6M90_00g002600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985934.1">
        <property type="nucleotide sequence ID" value="XM_066129533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0E3"/>
    <dbReference type="GeneID" id="26244196"/>
    <dbReference type="KEGG" id="mbrn:26244196"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="707" mass="77751" checksum="862AF1403F6D34D9" modified="2021-02-10" version="1">MDSTNPPTKPCHNCRRQRLRCDQSYPHCNKCTAAGKECLGYGKLFRWTGAVASRGKLAGRTSSAPVDAAARTAARATRVAGKKADLDFLTPSSSPPSLCSDAGTPVDMSMSEYQGDAKLVLRSPSPEGVVTSPWALADPLYQDMQYDHRYYLSYFTNRVCKDLVSQDIPERNPFRGLLPLTRAHPLLQHIIVAASAAHMSNLVRAPLAHHPKGVDDGVTVGIEQASRRALQDALVAKSKALTLMRGAVENIKTTGGDVVLAAALFFINVELIESGKHGWKAHLEGAGRIMSLLQPDSVADTALRDYMLSDCFIYFILASAFMPAASFDTQSYFQPSQIPFILQRAAANSYLCCPPEILTILHSASQLSNVSPDIASEEDVRAAGLVLIQEAQAFDINGWANDVRNMSYLQDAPIQSRIHAGSAHRLAACLYILQAIPSMSQMNDHGQVAEALSRDIFKHLSSIPDNDPNFKATTWPTFIAGAEAGGRARREWVMDRLQRLVRSCPWGFIYTAMETLQVIWDLDNKGQGTKSWVQTLKDPQMNFLMQRSKNFQDIWGIAMDQITSDRMLPSSQQVRCLDRLSILDDDAEGEDSLMPFWLLLQNILSGKRNSSSGVLLKCRIQYPTAFEDPLVLPGTIACSNKLSTILGPSSPPPYAEYRADCIGTTRTLPTRKHQVPQFWRSLAFIQNGNCLLGGATVSLYVIRAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0S3</accession>
    <name>A0A7D5Z0S3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19</name>
        <name evidence="5" type="ORF">G6M90_00g056330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986791.1">
        <property type="nucleotide sequence ID" value="XM_066130614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0S3"/>
    <dbReference type="GeneID" id="26242638"/>
    <dbReference type="KEGG" id="mbrn:26242638"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="151" mass="16763" checksum="18C8A0A110C37A50" modified="2021-02-10" version="1">MTGGISVRDVDAQKFINAYAAFLKRQGKLPIPGWVDTVKTGPAKELPPQNIDWFYVRAASVARHVYLRKTVGVGRLRKVHGTAKNRGARPSKHIDASGSVDRKILQALEKIGVLEQDEEKGGRRITQSGQRDLDRIAQTTAEADEEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z279</accession>
    <name>A0A7D5Z279_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539281.1">
        <property type="nucleotide sequence ID" value="XM_014683795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z279"/>
    <dbReference type="GeneID" id="26247922"/>
    <dbReference type="KEGG" id="mbrn:26247922"/>
    <dbReference type="OrthoDB" id="4941173at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028866130" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="96" mass="10061" checksum="23EB019D9D638B13" modified="2021-02-10" version="1">MKFSVALFALASYLASAAPTGPSPDASGLSKGGLPADSIKARMSDDAVKSARHSARLNPDVIEAPYYLTGELQERSEALNPDVIAAPLYLVGELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2B3</accession>
    <name>A0A7D5Z2B3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g030830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986262.1">
        <property type="nucleotide sequence ID" value="XM_066130075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2B3"/>
    <dbReference type="GeneID" id="90967583"/>
    <dbReference type="KEGG" id="mbrn:90967583"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="128" mass="15054" checksum="67DFC3ED5C9E01D5" modified="2021-02-10" version="1">MCFRERKAHEQLTLLLQFLDEHVMAEFRAERAQQEGLLYSVFDNPPGDWTYSAWKLLKKQCKYYKGKSRRFPFNEVDGLVMTDLKTYYAKATPPDLMEDTDCRNWVTDCVCAACRERNSVSTRKQIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z353</accession>
    <name>A0A7D5Z353_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FIG4</name>
        <name evidence="6" type="ORF">G6M90_00g072990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545763.1">
        <property type="nucleotide sequence ID" value="XM_014690277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z353"/>
    <dbReference type="GeneID" id="26241796"/>
    <dbReference type="KEGG" id="mbrn:26241796"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="238"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="758"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="816"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="975" mass="110863" checksum="A9835E7C771C138D" modified="2021-02-10" version="1">MSSNKAGEGSTGSPLPIAGDRHQKSPAFPQLQNNEETDLFTDNGEQKDRIFVQLDNDDQPAIPQPVGRASSRISPDFVPTTAGNNSESGGVFPNFAHKMHKFNLYETASRYYVVGVDVSEKRYRILKIDRTTEGAELNMTDDKISYSLKEINQLLDTIDHGNRGTGGIKLRCTTWGIIGFIKFTGPYYMLFITKKSTVAMVGGHYIYQVEGTELIALTPGKSKADSRNTEEQRFLSILNNLDLTKSFYYSYSYDITRTLQHNIMRERSALDKGVMPSSDDEPNTMFIWNSYLLKPAVKVLQAAYDWCRPIIHGYVDQAALSIYGRTAHITVIARRSRYFAGARFLKRGANDLGYVANDVETEQIVSESLTTSFHSPGPRLYCSPQYTSYVQHRGSIPLYWTQDSTGVTPKPPIELNLVDPFYGAAALHFDDLFRRYGAPVYVVNLIKSKERQPRESKLLEEYTHSINYLNQFLPPGKQIIHKAWDMSRASKVRGGDVIGNLELIADSVVSTTGFFQNGDGQISPMSAQNGVARTNCIDCLDRTNAAQFVIGKRALGYQLHALGILNDTTVNYDTDAVNLFTHMWHDHGDTIAVQYGGSQLVNTMETYRKINQWTSHSRDMIESFKRYYNNSFLDSQRQEAYNLFLGNYVFSHSQPLLWELTTDYYLHHTKPRDWSVMKPCNYINWYTPSHLRERIIPRLAKLPAAVASLPVEAVDDYWLEYYRPASLSSFPKMFAYKMNSTIKYIPLKSTQDGRYDLSPFRVRAETDTDSDKRKPKREGIDSPLTSSHIQQFEDVTSSVKSGRTAARGISFQRWLQPVQEKATEQGSMSEIHPANSDNGQPKREKMKPSALEKSKAAQWTFTKAVHDSLNPSVREQEAEDYDRYIRHPQNLPLVVSNDTPAGVDSSEYREYINGSWREQGLMVIGIDEEMDVYGELLKVGENPLTVTDEDSTKKRYKAYRKWLHGKSFFKQQPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3H6</accession>
    <name>A0A7D5Z3H6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein MSN5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MSN5</name>
        <name evidence="4" type="ORF">G6M90_00g042770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986442.1">
        <property type="nucleotide sequence ID" value="XM_066130307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3H6"/>
    <dbReference type="GeneID" id="26240176"/>
    <dbReference type="KEGG" id="mbrn:26240176"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1265" mass="142559" checksum="0DC2947437A4A7C5" modified="2021-02-10" version="1">MSASGGTLPAGGNPSNGEDTEILRRIHQALDVVHSASSGNDARRQAQSFLEEVKDIPEAPFQGYRLAADKTQPPVVRHYALSLLEHAIRYRWSTYNQEQATALRHWILELSQSVSKQDASYLRKKTAQLWVEIAKRCWGTEWMDMDSLLVQLWQIQDSAVHKELVLFILETLSDEVFTGDDSVVTMREGVLSKACVEIFTPTSVLVEAFPNRQPGPDVRHGPEGWLERISQFLNYCVSSEAKDTADAKSCAVKALSVFVSLMPWAIPKAIAAAQCVNVMTAGLASSHIDVQKASLEALNALYYRSNFTDDEFCDLVAPMYSPSSVDLCKGLYRWATVDPEDIDEDRYQILKKLSEMLSYLGDYFERKFAKVPQEAASSEFLGLLIQVTQSPSLMVSIPILVTWTRILGHRNLGPSDLVSKTVGPLLDVCTSRLVRYENLPENSTDPTYLFLLDDTDTIPERHAFLGNYRRYSSQIIEQIVQLKLVDAVSYILGRTEDILQKLYDGQPPFSKQTYTKHSTPALKVDSHFTVIEATLKGYVKWRRYHGRDHEQQVAEMESNLEVWCNKLLAMSFEDPIIRKRALQLLVFFSTTALNKDAGFMLKVLEHILLTWPALEPEYRAYNDAIKDLQSESMIELQRLAAEMPDHLLGVYDQIESRVNDMMTSGALDEKRSLAYRSFLFLIIHRASGIDTQTKIQKLAEFVEPVKAQWQSEPIRTSLKSYADFCQYLGLDKAQKYLASRHAHELKDWGSCELDSEGLLLQNELEERLKTLPLRPTKSFLAFSVERLDKSSPAFQASYALWQQGFSNILADLLEYLKFAHATHNPDSWVELPTEMRSMVERVLSDRFWQAGISEGSKDDFYARVMDKKNTIEGLASTIRGSFYGFNGLSGPLSEALFSDSIWLSTHQQSNLLNLVRYLVDDCPVDYREQFLPQLLAACFRQMDAKVNGEWERMEKQQTCVVDGEAGLKEEMKAESILRQVTYTAVMMVADFLDPTKSNSHTLKSRSRKEGLEDEPSRPYPSLRKFCLMRQEIVEPLLVFCTHGIRMRDTRCCGMVLRLFISLVPEFQLVQGQEQYGSTGNIHDGKAGSSHTDTTPVPAEIASVIREYIAQDVLKACLTSFHEPYFVEVQKELASLIATIVVYYSPITATPKDIILSLPNVNPAELDRLAPYMAKPASHPRQQRAIVLELLKDLKGVSVSEMGKLAKTAGFGGSSRNKRGNRSKMAQGFMNAPTEADGRVTRGNGVVGARRTTPDALEGVSNLFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3R8</accession>
    <name>A0A7D5Z3R8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zeta toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g087100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542408.1">
        <property type="nucleotide sequence ID" value="XM_014686922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3R8"/>
    <dbReference type="GeneID" id="26244922"/>
    <dbReference type="KEGG" id="mbrn:26244922"/>
    <dbReference type="OrthoDB" id="2881954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta toxin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="332" mass="36450" checksum="41444CCF2B652637" modified="2021-02-10" version="1">MPPPPDLSSYRLSDQDSQHIFASEILPAEFDHLPSHHGPQTSPPLAVLAVGQTGSGKTRLSPAILSAFHLVRGAPATGPVHLIADTYKTYHPEYTRLMLSTPNLASPATGPDARKWLAMASEEVVRRKLDVLLESACRHPDDFVQLARVFSTAGYRVEVVLLAVPAALSRLGILVRFYEKLPEGQSRNLPVRLTPTKVHDDSYAGLLDAARFLDETSTADQVLVVRRGNLVAYGTTKSANGNMVNRRGVEEALKRERGRPLTAQEMKTALDDVQKMSTHEDASEQVEHIRGMLKPLIKDSSQDGWPELKPLNFGKVNEEAGGTYNVLRLGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z445</accession>
    <name>A0A7D5Z445_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-labile enterotoxin IIA, A chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g066390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539259.1">
        <property type="nucleotide sequence ID" value="XM_014683773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z445"/>
    <dbReference type="GeneID" id="26247947"/>
    <dbReference type="KEGG" id="mbrn:26247947"/>
    <dbReference type="OrthoDB" id="4862906at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028983918" description="Heat-labile enterotoxin IIA, A chain" evidence="2">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52719" checksum="2BC351014340026D" modified="2021-02-10" version="1">MKIISLALLALAGINFASPTAALQVRSPPPAGSEQARELYELVKKGMRSWGLAGAIHPPSGHISAPSANLPGGLPELNRPRPPKPNGVPGTPGHPLGPRKKQGRIYERRKSCVAQKRSGIKCSAGTRVTTRASRFPKLRLIGQGGVMVAFSILSPHAHEILEAVKNWDNPIGTAVGWFDEAIKGLQEAIGGKHVPEIDGNELKLRLICLFRANSPKHPDVIDDLCKRHQDESLEIKKQQQAIDGLNQISDLCKKVEEEGPPIDVKIKRDVLALCDKYSKTIEGMVDANAGLILLGEWARARTLNNQDLEESDVAVARRFIREGAFGLAIATNETEASAIASLYMAHMSSYTIMEIDEDGNEELIYHSKPPVWLELLQTGASFVPEDREGINQALKLLDGTPYLHHFDNEGREDRFEKVQTCWSHTNLLMFQPPRWDLIAAAMTYLEGRVRDLGLEQILACTPCLVLSDFWVLRCGSAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z454</accession>
    <name>A0A7D5Z454_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542624.1">
        <property type="nucleotide sequence ID" value="XM_014687138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z454"/>
    <dbReference type="GeneID" id="26244573"/>
    <dbReference type="KEGG" id="mbrn:26244573"/>
    <dbReference type="OrthoDB" id="10280755at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="211" mass="22505" checksum="EB2FC5CD91A6EE5B" modified="2021-02-10" version="1">MNPILIPGAMIPGALMIPGALMIPGALMIPGALMIPGALMIPGALAPNFGCVVSWAHTPRIGTPRIGTPRINQYFDICLPGIKTPDIGSVRAPRIERSILDGFGRDPGMCEASIFRESGETATESDLVLLKNSLPFLESTTRYFWHFVPGSSGSGIARDLTSVGGSSGKRHEKAVAWNLCGQTLNMKFEPMKKGLLSGTSHWITVTTPVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5F1</accession>
    <name>A0A7D5Z5F1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g104790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541471.1">
        <property type="nucleotide sequence ID" value="XM_014685985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5F1"/>
    <dbReference type="GeneID" id="26245721"/>
    <dbReference type="KEGG" id="mbrn:26245721"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="56865" checksum="D4756CAB7643242A" modified="2021-02-10" version="1">MDSLPTEIIQHICKQLCFHCQHQGVFPNADSRDVLAHKSSLSRLCSTSKRLSVIAQPVLYHYYATGNLPTTAGFGLNHAIRASSRDDKLSLFVRTIMQRPDLAGHVRALQLVDSDVVKGCSLDLLRAFETKAEECGMRVLEDDSSLSDVDSFYEDQPLSSLEGHRWLEGLAIALSPNIEMLLIAHNTPSRPFVNVDINLSRLAKLAIRGYSGQYFFSEAVPLLSAAPNMQTLYLLDCCHLTGWNRILDMEFQPHFELALANLRSLVINGPHPEHLDEILGYCCQLQDLEYYEQTTIGVSNVRQLVESFLRVKRTLRRLYFAYLPRGRFDFNCGFHRTIEGLDADEQYRDYVECSLAESYDTSAIELLRDFEQLEELGIDQASIYSPSSPDAETNPGRLSRLLPPNIQRLRVMYVYRAMTGDLYCLGRQAPYKFPELKHVRLGQAISITPERQAGLEEMKQISSIVTTMGETISVSWAIDELGADVRTRIPGGTVHPQFIPCPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6W9</accession>
    <name>A0A7D5Z6W9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987964.1">
        <property type="nucleotide sequence ID" value="XM_066131874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6W9"/>
    <dbReference type="GeneID" id="90968282"/>
    <dbReference type="KEGG" id="mbrn:90968282"/>
    <dbReference type="OrthoDB" id="4943172at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="41085" checksum="EF043FEBA5F830EB" modified="2021-02-10" version="1">MSDKDSTLFIGDSDPTCPAGVTPQPDGYVSGQSYQQTYQKFSCSRIDMYLGNILPEWPIFTPDEVLAMRQKYLAGQGSDNDRLSMLVIIDLADTMNPIHSQDIQELQFGLRYRRTIQTHALLALYWKRRGFHGFANEHITKAFALGSSSGVQWKNSSLDDHFADIVALWCCCFIISEYPIHTDMNPVPPSLYKYLPLPSKDDIVRKFGTSAGAFFELRVAYISPRLTSIPRPQLECLPLELVEVPTPLVTLKERYINTHGLSINPQQSRFTSLESYIKMIQEFEPANRRWAFPTERFCLYQLTAIYSDTNQRSICILLVERTLKFLDPVPDCLTTMDINSIWVLWWKLWGYPCLPHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8V6</accession>
    <name>A0A7D5Z8V6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g061200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542748.2">
        <property type="nucleotide sequence ID" value="XM_014687262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8V6"/>
    <dbReference type="GeneID" id="26244697"/>
    <dbReference type="KEGG" id="mbrn:26244697"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="456"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="801"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="878"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="935"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI69589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1173" mass="131974" checksum="37EF2F91E9F9D479" modified="2021-02-10" version="1">MNRRVEDAIEELTVQQVLLSSLEGQTWDGVEEERNIVLRNIERLKGRIKKLRREAQAQAHTDEKTDVVRSASQAQSPSDSSNKLSCPQPMTPVATGGRSIRMDSSSSYHDIWDSPSSTSLPSRKRDLRAADGLTVDGQNKSRRTTPIPGVKHSSTPSRQAMEYNDTEPIDIIDLTGDDVDFDSTMVAEQIRQQQRQERENRDRKMAMQLASQSPVVPSTSSDMASDEMDAFSRIMATERANTRGPTGWNWQSLPASSTQTPMPPATIKGASTAGPYDLSWDNPSPWDRSPVPIPASLPSNGFQVAGINSPSGNRQSPSGFNAQLNSPYSTMRHQLSNQAIRNAFQPLSSSRVIPFNGVSWLPGKNGSSIANIIEQTSTFDFANGLDTFGNPLPSRLTNVLLGDANDSPVTGKELDDLLANIRPDIDIPEHNRGVGPPGLKFALYRHQEVALTWMKQMEEGTNKGGILADDMGLGKTISTLSLMLSNKSSSRPKTNLIIGPLSLIRQWEEELQKKTKLAHRFSVFVYHGKKATTDELLKYDVVLTTYGTLAQELKRREKFIEENKDRNIDFNDKSCMAKFPLLHPEKAVFHRVILDEAQCIKNRNTQTAKACHSLRATYRWCLTGTPMMNGILELYSLLKFLRIKPYNTWESFRQTFGTLFGQRGDPKSIAMNKLRALLKAIMLRRKKDSKLDGKPILQLPMKREHAVYAELSADERDFYKQLEEKAQVVFSKYLREGSVGKNYSNILVLLLRLRQACCHPHLNLDVDDAVNPVSSADVEELVKQLDASIVERIKGVEAFECPICYDAVQSPSFFIPCGHDSCNDCLSRIVDNAISQNLHEGNESDKAKCPVCRGVFEPRKCFTYDLFKKIHMPDALESSTKIEPGYDDSGEDEEDGSEQGNSSDELDSKGNLKGFIVYDDDDDELADIKHLTKEGSARDTKARKRTKKTKKKDKGKGKAKEKKADVKPSMLKSLRLEAAKNHQAYKRYMAYLRKTWMPAAKVTECMKLLREIRETGEKTIIFSQWTLLLDLLEVAMWHEQFPDKPVRYDGSMTGDERSNAAKDFRDRSECNVMLVSLRAGNAGLNLTAASRVIIMDPFWNPYIEMQAIDRTYRIGQQKEVEVYRILTQETVEDRIVALQNKKKEIVEAALDETESMKIGRLGVSELKFLFNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9A9</accession>
    <name>A0A7D5Z9A9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Subtilisin NAT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aprN_1</name>
        <name evidence="12" type="ORF">G6M90_00g081830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543418.1">
        <property type="nucleotide sequence ID" value="XM_014687932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9A9"/>
    <dbReference type="GeneID" id="26243595"/>
    <dbReference type="KEGG" id="mbrn:26243595"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028819086" evidence="9">
        <location>
            <begin position="28"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="147"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="11">
        <location>
            <begin position="438"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="867" mass="92272" checksum="259B57EDE515107B" modified="2021-02-10" version="1">MVRLSASALACLAAATVSFSTSAVVHAQEIAQNAVAGAFLLECDSQSLKPLIKTVQEQGGEIRREFNSEVFYGFSAQLSNASVAGDELRHMPGVKKVWQVQVSKHQESPPAESQATPESAHQRRQVKSPWNHVMTQIDKLHAAGFTGSGIQIAVVDTGVDYTHPALGGCFGKGCRVALGDNFAKDGKDNDPMDCSGHGTAVAGIVAGSDANYLGVAPNATLAGYRVLDCSATMEEDGLIAGWVKAYQDGAQIIVSSAGWPGAAWATRPAAAVVSRIVDSGVPCIVGLGNDNNSGLFNTLNPSSGRGVTSVNAFARAPGAIDGHVTDAPVAQFSTFGPNWDLEIKPTVGAPGDDVPGIKMGGGYEDITGTSFAGPLVAGILALVAQVRGTFDPVLLNSLLTTTAVPQGKYYSVAQQGGGLARAWDAAHATTLIEPGSLSFNDTLHRADSRSLRITNTARVKVTYHLDTLAAKTIYTLENGGGRVQHLDRPVDESADVKLSRRLLVLGPGESASVDVSATDPKGLDPERLPVWSGCISIQSSHGGSSKCSNSSSVLTVPYLGVSGSMKEHQVLQPHGVVLSTLLDNGRDQVHTGGHRVDYESKNDGSVSIDLPVRITPVLGTRLVRAEVVPLSPRKWLAARLADKNLKLDAFSLEALAHAYATRKTWSGRLESGDYIPAGEYRLAVRALRLFGDAAVASDWDLSEDVSFEIIRPAGRKACERYESSKGAVPADALFTSLEECLQVHGDKVVDAPWVPAPQDKALRDRCANGELTDELCGTYELCRKHKDIELLSDVKSPFTSLSSCIKSHKTFPFKPLDYSRIQECMANQDDKSICGTDLWCNLHFGSPQPTDEYGSSEECRWAHGNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB23</accession>
    <name>A0A7D5ZB23_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase AflY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aflY_1</name>
        <name evidence="3" type="ORF">G6M90_00g096550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987614.1">
        <property type="nucleotide sequence ID" value="XM_066131512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZB23"/>
    <dbReference type="GeneID" id="26241102"/>
    <dbReference type="KEGG" id="mbrn:26241102"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="534" mass="58125" checksum="48863A869138D468" modified="2021-02-10" version="1">MSRIAGDTITTASGAGVTATRIALRLFRNRAIASGNLYKSRRDPWEAAPTPTGHMHSVSRIASRTTAPSPSGITTRAYSIRSGLRANMASATRIVIGAGDTGFWKARQDEETAAKVSALLQADLEKHHVFFNAAGYHNHLVHQLLALYGTGAPESAIQAAFDANAGYQLKHTPARPHVVAELQADWAAHAPKYLGRGAYYSDFLRFFQDEVDRRGWQAVVTSFLCAAPGDAASPARHMVQRLFSGLVHPMIQLGFGLEWEQPAIVAQGLAQAAVHRNTLGDFFDRVDEAVAAAGRGGQQRGLSDICESLRAENGSLAAAAEWRDGDQSLYAGVLGRGLDEAVALCAQVRVREGDWDERVAEALHHAAYVAASAAWKPPHVPKYDFFLIHALNASVFLLALDKPCFPAAARVRILEHKMRYDVLQYAARGAPRLSPAHAAAYRDTNSDVLAARAEDLLPRYHAVADDGHAIKAARALLLAQRVSRRWAGRPWVRLRDDADWRGAHCMLLRGVEGDEPLWVRGAGFDQAWEGVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBC4</accession>
    <name>A0A7D5ZBC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g081240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543363.2">
        <property type="nucleotide sequence ID" value="XM_014687877.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBC4"/>
    <dbReference type="GeneID" id="26243540"/>
    <dbReference type="KEGG" id="mbrn:26243540"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="5">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="25141" checksum="9620438E6B2526CF" modified="2021-02-10" version="1">MVSSDPMDTLGHGTQVAGIIAGYDAENGFIGVLPNATIHAYAAESDLTTSTEDTMIAAWLEAYKDGAQVIVSSIDLSSSWAERPSALVVSRITARGIPCIVALGNGHLGPFDAVSPGTGRGAVAVNSVSRSHGRITGEYVYRINSDADIAFGVRMGEPHAWDTEELAVHDIDADYGGNIDDMEGPLPDCQPRPGDDGKKDLTGRVALIRYPVRDEQHCIFEQRVLNATARGAIHVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBG1</accession>
    <name>A0A7D5ZBG1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH-dependent reductive aminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">REDAM</name>
        <name evidence="1" type="ORF">G6M90_00g104220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541418.1">
        <property type="nucleotide sequence ID" value="XM_014685932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBG1"/>
    <dbReference type="GeneID" id="26245668"/>
    <dbReference type="KEGG" id="mbrn:26245668"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="99" mass="10940" checksum="F6E612F3F1FF5785" modified="2021-02-10" version="1">MANVTNGTPRQAWEMQEWIKPRGAGYYFDGAVMIPPQLVGTEHAFFLYSGEAEESFTKNAAHVVSSLGFAQYTAANLNPAAAALPHHNKQWFILDLMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCC0</accession>
    <name>A0A7D5ZCC0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump terJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">terJ_1</name>
        <name evidence="8" type="ORF">G6M90_00g110560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987946.1">
        <property type="nucleotide sequence ID" value="XM_066131811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCC0"/>
    <dbReference type="GeneID" id="26243190"/>
    <dbReference type="KEGG" id="mbrn:26243190"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="544" mass="59156" checksum="D6D98CEE58226550" modified="2021-02-10" version="1">MSITNDTAEKGPSSGHDGKGSEYFDQATIERLGRQRPEALSNWLAESFFVFTIVMSMMMSEYFIGGFNIVLPPIADALEIPASSRTWPAGVTNLTTAALLLPFARLCDLYGGRVVFLCGHMWLLTWSLVSGFSQNTTMLIVCRAMQGIGSAAFLPAGLAILSQTYRPGPRKNFVFAIYGAFACIGFYFGIFVGALTAEYLDWRWYFWIGAIVGLAVGISGSISIPRHLDDVNPNARMDWLGVVTIVPALVLIVFAFTDGGHAPDGWKTPYIYVTLVLGILFLAVAVYVQGWVSAQPLLPADLFKSRYMKRLMTALFLSYGVFGLIETVMHTKPILTAAWFTPLAVGGMVLAIAGGLVLHIISNQILMIISSLGFILSVLLFALIPDPATSGKSTSFTYWAYIFPAMIAGTIGVDITFNVTNVFITTAMPRRHQAAAGGLINSLLYLGIAFWLGIGELAVSATVQSRGGHEKVDAREQYRIGFWTALGLAIVSLGLVLTIKMGSAEASMTADEKAEMESRLQSRQQSQMQLEEQPPQAQAQQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPZ5</accession>
    <name>A0A7D5UPZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UTP11</name>
        <name evidence="8" type="ORF">G6M90_00g026910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547895.1">
        <property type="nucleotide sequence ID" value="XM_014692409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPZ5"/>
    <dbReference type="GeneID" id="26237339"/>
    <dbReference type="KEGG" id="mbrn:26237339"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="279" mass="32040" checksum="413A05F46A4CA46E" modified="2021-02-10" version="1">MSSMRNAVARRPHRERAQPLERGRLGLLEKHKDYSLRAKDFNKKKTQLKSLRQKAADRNEDEFYFGMMSRKGAGSKLKDGKSWTGKLEGDRGNRAMDVDTVRLLKTQDIGYIRTMRQVVVKEIARLEQQVVLTRGLDRLEDEEDEEDKEDDLDSDDDETPLPAKPKAPRKIVFMDDEEEREATMLDRLEAEQNDDGDEEEEEKGRNAAAADGEGDDEEADPVKSLRRLKRQLENAKKQLKAFNDAEAHLDVQRAKMAKTATSGGNTRRGRKIMVRARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ23</accession>
    <name>A0A7D5UQ23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FRE7_0</name>
        <name evidence="17" type="ORF">G6M90_00g017230</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548807.1">
        <property type="nucleotide sequence ID" value="XM_014693321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ23"/>
    <dbReference type="GeneID" id="26238251"/>
    <dbReference type="KEGG" id="mbrn:26238251"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="294"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="511"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI63976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="623" mass="70417" checksum="22CCBAC1E4CEBE19" modified="2021-02-10" version="1">MDMGDMHMHDAGLGMDYNYAFARDYWYIIAVVVGGLTALRGIEIYTGKQRLKACKETSIEHATRPGNHVSQAWATATAITREMSHPQLYVSRVGFRWATPPPLGRIMVLLCYWAMIIYFMSWNVVKNDAYFWERIGYRNAWVSIMQLPFIFLLSMKFNIVGFLIGSSHERLNWLHRWVARTMFVTATVHGWHFWTEWVRADFLEYELSIMPLVRYGLGAWGVLLFNVVVGFVPIRRMVYEIWLIQHVLSSVAMLVLLGFHIPADARYLLWMSVSFLAFDRAARGALTAWQNTRWKPSTSACEGMRRLGHSMSSRAIGDSITVLTIKDVHFKWHAGQHIYLWIPRLGFLESHPYTIACAHQIKGSCCCNSIQLIIRSHGGFSKRIHNFAVKNPAKTLTGYVLGPFGVTTRWETFETLVLIGASTGASFTVPIMEYVAYSENTSCVRRLEMTLVARTAEEMEYYVERARDAARSAQEKGIMVRLHIAITGGYSETDSGVPLVQLRRDVKDGSTEGSIKEKAAASYSGKSVEDGLRSRSRNSCSSTSRNSTSTVDMVREYASRPDIEALLREPVEQAWGETAVVVCGGKEIVARTRNCVGKLSDERAVHKGTGAQGIYLHVEEYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URJ2</accession>
    <name>A0A7D5URJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g023710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548185.1">
        <property type="nucleotide sequence ID" value="XM_014692699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URJ2"/>
    <dbReference type="GeneID" id="26237629"/>
    <dbReference type="KEGG" id="mbrn:26237629"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="311" mass="33467" checksum="A87CD83C93F401E8" modified="2021-02-10" version="1">MATNGDGSSLARAESPTGSPRSASVSLQAAATMNAGLQREPSRRSSTSSLARNPLSPNTSRRRSTVLMNLQLNDPSVPAPGEMAQEHSGYHRSSPQPLSGSPLMADPHHHRAPSLGELHQELEAEQEGHVNRLLQMIRQQQLELQRLQTSRPGHSADPAAEDSAIAETVPRPIYGAGGASQSNIPGSQPVGSYSRSPVFPRGSMEMARAEMHRRSRTPSRGASPRLRATSISQESGDWVLGGRDESAFYQAETQMLTRENQMLRHRIRDLEKQLAEFHPGSGTGTEPSIPSHLTQSSTSGEPAGEVGPKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URT7</accession>
    <name>A0A7D5URT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985879.1">
        <property type="nucleotide sequence ID" value="XM_066129965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URT7"/>
    <dbReference type="GeneID" id="90967532"/>
    <dbReference type="KEGG" id="mbrn:90967532"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="237" mass="26690" checksum="2A5C88DBFFB7F346" modified="2021-02-10" version="1">MATGLTILRIIGNTSRWQTWAVCIFMFLTVSACIIGFGVSVFWCGNPINTWMIEGWATANCVLLGGASGSSSLPWGSQSSRALQLARGTARRSARVPTETRMERVVSVLENSAKRRRLSEAEKGMLGRYNEWIATINQRPRWKWEGGPRKHVDLPQTGAGASWRKYYQVRDLVTKHRMHPKETAEAIGDSYWELLRGHGYNSIRLDGANRLVIAINDMGRSVQVISIGTYNRLRIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URT9</accession>
    <name>A0A7D5URT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NOG1</name>
        <name evidence="11" type="ORF">G6M90_00g023860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985761.1">
        <property type="nucleotide sequence ID" value="XM_066129913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URT9"/>
    <dbReference type="GeneID" id="90967503"/>
    <dbReference type="KEGG" id="mbrn:90967503"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="452"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="657" mass="75461" checksum="163A068F602EFCD2" modified="2021-02-10" version="1">MKTTWKDIPPVPTQQEFLDIVLSRTQRKLPTQIRAGFKISRIRAFYTRKVKFSQETFSEKFGAILESFPRLQDIHPFHKDLLNTLYDADHFRIALGQLSTAKHLIETISRDYVRLLKYGQSLFQCKQLKRAALGRMATICKRLKDPLLYLDQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLKSITRADVDVQPYAFTTKSLFVGHFDYKYLRFQAIDTPGILDHPLEEMNTIEMQSITAIAHLRSAILYFMDLSEQCGYTVQAQIQLFKSIKPLFSNKLVFLVVNKIDVTRPEDLSPELQEELQGLMKAGEIEMLQLSCNTQEGVQEVKNAACERLIAERVNQKLKAGTNNSGNIGGRLADVMSRIHVAQPMGGQSLETFIPEGIKNLKKYEKEDPERRKLARDVEAENGGAGVFNVDMRADYLLENPEWKYDKIPEIFDGKNVYDFIDPDIEAKLAALEEEEEKLEQEGYYDSDEEIDDDEEAEVLRKAELIREKQQLIRNEARMKKRLKNQAIIPRSKTKKSFSQLEDALDQLGVDTRNLADRAQPKDVRRGRSMSRSRLGTEDADSMDVDSKPRDRLRSRARSMSRAPTTNRREDGVQDELTRSKAERIAKLNQKRMNRMARQGEADRHTTVSLEKHLYSGKRGIGKTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US59</accession>
    <name>A0A7D5US59_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sexual differentiation process protein isp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">isp4_0</name>
        <name evidence="11" type="ORF">G6M90_00g001040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542966.1">
        <property type="nucleotide sequence ID" value="XM_014687480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US59"/>
    <dbReference type="GeneID" id="26244339"/>
    <dbReference type="KEGG" id="mbrn:26244339"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
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    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="8"/>
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            <begin position="29"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="773" mass="86288" checksum="A2B1A887F3FFA841" modified="2021-02-10" version="1">MKKPLQVSSADDTSPSSKSATAAETALGEPKRDHAMKRGDAQRLAHADHVLGEDSPYEEVRAAVRNTDHEQVASTVRAWILGIIFVTVGSGLNMFLSMRSPAINFPAIVVQLLVYPVGCLWARLVPARVFDTLGVRWTFNPGPFTIKEHVVITLMANVSLGYAYSTDALLALQGRPFYNLNLGWGFSLLFTLSSQLIDISLAGLFRRFLVWPAAMMWPNQFASTSLFYALHDKSKGDDGLRSNGWLVSRYRWFAMVAASMFCYYWIPGVLWQGLSVFAFATWIRPRNVVVNQLFGGTTGLSLIPLTLDWTYVTAYLGDPLLAPTHSHVNTLVGLFVFVLVPTIGMVYSGTLFADHLPLVTAQTYDNTQSNYNVSRILGSGFTFDEAKYREYSPLFLAPTFALNYGLSFAALTAAIVHIALYHGNEVWHRFRAARSQEPDVHLSMMQKYAEAPDWWYGALFLLAMAFGLATAEAYDSQLPWWAFFVSVLVALVFIIPTTMILAVSNILLSLNVISPFLAGFMIPGRPIGVMLFKVFSTITLGQAQTYSGDLKLAHYMKIPPKITFWCQVVPTIWAVFVQIAVMNWTLGNIPDVCTNLQRNHFTCPNGRAFFSSSIVWGVIGPRRMFGVGGMYARFNWFWLVGAALPVLLYLLTRTLRITFFRHFQAPIMLGAMAWLPPATPLSFSSWGIVGLIFNKWIRNRWNGWWTTYNYTTAAALDAGLILSTIVIFFAITFPNVTVPQWWGNVAVFETLDATYAAILKTVPENGTFGPGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTS5</accession>
    <name>A0A7D5UTS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g027390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:histone acetyltransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:TBP-class protein binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="419"/>
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        </location>
    </feature>
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    </evidence>
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    <sequence length="1223" mass="139427" checksum="C76221959117541C" modified="2021-02-10" version="1">MADDTEFSSFDENAWKAQDAADDREIARLLEQSQEGGNSSLKLDDTPFDQSNKADDAQDFEDISDDDLPDEEPSASTSLELPALTDDGGTSNDADDLFGEGPSSPTDPILGPPSPGPRVRDTDTADDSHPIDSSLSFAAINFDPDPHLNGAANQDPDIPAVVESHEDLLKAAWPAFKKGRVLTWSELLPPKKATWKEKKPLKKPKHLVTSKLNLDLAADQEKMFRIPGTATSGPNHRALESSLAGFVRCENNGSNQEEDRSHFDLDQESDSETVVGFTLQDIDLACQDWGDQINAVETEFKKRVAAEKELLKPKKLVEDHDDEWDAEFLMDTMDEQPQQPKKRRAVKFGLPEIPRYAASTFDNFEDVTRRGAKRVHLDMNDPHLLLDTDMHLRAKRPRLDSKVKRMANGNMGRDISQRFNLSNDEAYELLKENHQSKVRATLGNISVEHSMPAIKLSWPYYKVKLGGTTDEYHRPRFRYKKFSGHVIKFDKPQHHKRKMMKGKAHEVYRLSKDLSLSDNSTAVLFEYCEPRPRVLNNFGMGSKLINYYRRKDNNEDDQLPKQELGEYRMLLPEDRSPFSLFGTVDSGETVPTLHNEMYRAPVFKHMPRGTDFLVVRSTTGVEGSKWHLHKIDHLHVVGQTFPSVDVPGPHSRRVTNASKNRMKMLAFRMIRHSQTDNCQLSDITKHIADSTDTQNRQKLKEFLQYDRESGEKGMWRLKPNEMLPDENAIRAMIKPEEVSLLDAMQLGIKELEDAGYDPRNANIDDDVMDVDAEDEDDDEGGSKAPKGAKKPGEKQEETLADKMAPWKTTKAFIDACAQKAMLQLHGEGDPTGHGLGFSFIRTSMKGGYIEAVQGPLATSADAMEREKRANGGHAYNVKKQQAMYEEGIKEIWEKQKSTLSDAQEHDDKDVAVTEDEDDRFNVHAAATPAQFDDGTSQISGFTSASRHVKKAICITREVRLQDGTTQTRTEVVHDPVVISQYMKRRTEADLELKDIYSSRPTGNADHDRLAGIRIKKELERLEKNKARRQAREQQKELHQKASAGEAGSPGAVDKVPTVSPPLYPSFDWWGAASHKEGQAVPTKKQARRKSVLHRLMKSSNREAREREKRRQIEERATARKVRKEENMAEKLKVQREREQKKIEDTRLREEARRQEDQAREGKKRRQEELRADKQRQENEQRRKAQEEREERRRLRLEREEENQRKKEEKAKARPKFNYGSCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU10</accession>
    <name>A0A7D5UU10_9HYPO</name>
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        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein nuc-2</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">nuc-2</name>
        <name evidence="7" type="ORF">G6M90_00g033650</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130133.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244093"/>
    <dbReference type="KEGG" id="mbrn:26244093"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14483">
        <property type="entry name" value="SPX_PHO81_NUC-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="707"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111771" checksum="E9E0AC3A0FFA3C2E" modified="2021-02-10" version="1">MASRPLLSEATQVGHIALTNLPPQLSLPMLIKKLSATPTLAAQNDILRQAGSVDSQASLQANKATFFFQLERELDKVNAFYLQKEAELKIRLKTLLDKKKVLQTRDGISRRSSKFTTLEEGFQQFATDLNKLQQFVEINGTAFSKILKKWDKTSKSKTKELYLSRAVEVQPFFNAPVISELSDQATTSLQELGAWSDGIQVNFQTPGHVVTSQHFMGTDEGDADTLLLDTVITGNLETLRELLTKMQSASSSTDGGSSLPDRVTRTFLTAIHDAPEESLRVLLDTGLVDLQSYDDINERNCLHQATIYGKQYVLEWGLKAGVSVDRTDVYGRVPLHYASLHGRLDMLEALLNVNSSTINLIDHDNFTPLIHSIIHGHIDCIQRLLARSARIDPVSDSDHVPLNLACEHGSEAVVELLLRHGANILPDAEGLYPQHLVARSGKTSELLLLLKKFGADLDQVDKLYGWTPLVHAASEGNVDCLQALLKVGVDVNIVDEKDLPAMYYAAWEGHLECMKLLTPFNTHIRASPLVLQSSPGPTDSSNAPGPMSLDPDAIPILELPPPIIPLRRYGHNFLDTKTVVQLSFDDLHEQPLIFFQDGKYPAARLTISSKLSDLIPKNIILPFQEDTRMVSFQVDNLDTFSLDFDVFPTYGAKIIAKTVVLPSAFKTQQGGISKCCLPLFDPRLRAIGQITFSTQVIKPFNGQPLEITDFETYWKATSQFNQPTSAVVTGSSLSGDYVRLFVQYTADGVPVIWSQWTISCGGLDLPLCRLSLQQFLTITAENTCRAALPSLSSKTVDNIAEVYHILATAGITLKDALAILPRGINVNLQVLYPTQEEEKALALGPALDVNVFVDAILTVVFDHARAQRAQYQSPEAARSMVFSSYNARLCTALNWKQPNFPVFLCNDLGREDNILEENMLRPSGRRGTSIKEVVRIAQSNNFMGLICYSKLLDMVPALVDAIKSHGLALVMDKSTDSPSTSPMTDPFPRPPKGVDGVLKNHGILRFNDSIDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU59</accession>
    <name>A0A7D5UU59_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argonaute-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arb1</name>
        <name evidence="2" type="ORF">G6M90_00g046180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544746.1">
        <property type="nucleotide sequence ID" value="XM_014689260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU59"/>
    <dbReference type="GeneID" id="26242087"/>
    <dbReference type="KEGG" id="mbrn:26242087"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="478" mass="53560" checksum="39BB827E570F2BA2" modified="2021-02-10" version="1">MSPQVDEGPLISDATGVTDQADSHYNRGDSDSQQIHDQDDTISMNPGHQAASVKKKKGKSRGNKSTAQRGPTALPRNRGTGFEEYFADPPMTPDEAAEEKLEIYADCLPFEERIQSCIRRFRARRRIQGDQIRYFDEYLFLGGIDTSGNAFSGLDTSDLKDLTPAQRREATVTDTVNGACGADDRFYNGDDEHWSVDFAGVAAGLFSTSLGQLTGFEPKKTESLISLVENFLRYVLLHEVCPEYKDNIESALQVCNQARQEWPALNQLTAELPGYFNLAATELFSSVAVGDWSFLSFSKPSWYDPKTVFLAVCALCDEDLTLDEFHQDRVEASKECTYTLEVTRVEGPCSLTLDKFASLLIEGSDCGVSPVGKVFFKPAIIEDEWETPSMHISPQDANIWVYLERSLLTNVMPKMKMDITLVELNTGIRFIKTIHQIVPSFYTFLPQQMMRHYKQPRDDDRPAPSVHDTGTEEGQSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUG2</accession>
    <name>A0A7D5UUG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g030230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539736.1">
        <property type="nucleotide sequence ID" value="XM_014684250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUG2"/>
    <dbReference type="GeneID" id="26247493"/>
    <dbReference type="KEGG" id="mbrn:26247493"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="2">
        <location>
            <begin position="408"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="813" mass="91269" checksum="0BE0F9ED1129CBA9" modified="2021-02-10" version="1">MSNSISTCFAAAALVSFFCETGGEIRWADAVSVAFDAGARKVASSGSGNALIACAAIIVVSFSMQDLLHRAVGAVLHHARDQLDSMLHLTPGTYFAKKLADHNLLLPTVDKQITGCIDLDGLYARKEQCVPASCSYSAGYVSGRRFICWCIIGTQLLGCLLCVFLQPNLPYRHAAATLPLSLLSVVRSCILGAADHPDVTWPLPNLVTRLKWESPDGYFKGWAPGTDNEFVSKYRSRVPEWLPESPPSGFHRWEPQSKPTSGNTSDNATDDEHAESPDSASDNQHFYNPVNDPLKINNLHGNILPALRNTLELESVNIRHVVLIQMESMRQELFPLQKESNFHKMVLQSHDESKHDDVNLQLARLTVNAERVTGMSGDFHTADGRRIPPESKEWHDRTEAGLGGLNVIGTHTTCSSSIKSLAAIHCGVWPMPVDWCEESKLQSYQPCLPQIFKLLNMLKSETRNSSDYRDHKWYPAFFQSIADEFDDQNNMDQMIGFEHIVTRQQVDDQVANSGVDEEEVNYFGYAETAIKSHIKDYIKKAIESNQRMFLSHFTSTTHHPWSVPSWFDKTEYMGSARGGLTTSHEDMNNYLNTIRWNDAWVGEVMQLLDDFEISNETLVVFVGDHGQAFREDTKASGTYQNGHISNFRVPLAFRHPRIPRVQLAVNSTSINILPTVLDLLISSGSLNARDTDAASDIIQDYEGQSLIRPFEATHRGRRAWNFSIVNPGGRFLAMTSADVPWRLVLPWDDSAEYVFTNLEKDPLELDGILNWSLEGLVSDVERHLGTDAATWVREAASVARWWGMERKRLWKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUK8</accession>
    <name>A0A7D5UUK8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin POM152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">POM152</name>
        <name evidence="8" type="ORF">G6M90_00g042960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547630.1">
        <property type="nucleotide sequence ID" value="XM_014692144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUK8"/>
    <dbReference type="GeneID" id="26240193"/>
    <dbReference type="KEGG" id="mbrn:26240193"/>
    <dbReference type="OrthoDB" id="5529162at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="4">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="6">
        <location>
            <begin position="206"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="456"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="563"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="765"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="3">
        <location>
            <begin position="881"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1258" mass="140596" checksum="74439E9B274804D3" modified="2021-02-10" version="1">MSATPRLRSGFPATPATAPRRQNPQETPSTVGTVSSNGNSAKSPTLPLAPENNTARRVASDPLIPLTFLDAPQQRLYALAVYVLLWAWKLYDWLQVIEDGDSSWWLFIKWIFIDFAFLFGLPELRIPWLELSQFIVTTLFAGHVVFNYMLMFNIPLPWQAWLLGFAKVLYDREISISEHNVKISSILNNHSLIMGKQIINILPEGSAVLNPDMLPYCLNRKDKIGASLPIYFNATVPAEIELIRIDLDTNKEETIKIPTREVNKVARAIRDHNADPTADGFSWLYVVKKPGVYRLGKVLDQYKLEVQRAAKETYVVPCPQAKIRASESSQRCIRDLSDLSLEVMGTPPLKIKYSRSVNGINHDFRFQSLQPDGFASPLITGANAAAVSAADDFSWARPATVTVGLNESLTNPGEWEYSVDEVHDAFGNEVKYAKEGEDVDVANSKGLTQKFTVRERPKIRMDGCDLRKPIKVAKGRAASLPISFSLSGSIKDTSHEISWEFSPIDTLTNSGDHGSEATIFRHSAKNSRDRPFVSEAGLYTLKSVTSGSCEGEVDEPSSCLLLNPLEPHLSIRSEDIPDKCAGNSIGLRVDIDLVGTPPFDIHYDIISDGPPEHKTLRVPGLRSQLELIPKKAGRHRYVFTSISDAVYIGLPLSGQDTILEQVVKPAASARIVHPRDTINACLDSEVEVDVALNGDAPFNLEWEIVHDGKRKTERASNLEDNMFKIKTPVLAKGGDYILALSSVQDERGCRTFLQEQIKITVRRQRPRGGFGLIEQKSSILAVEDTSLQLPLRLQGESPWTIRYRNLNESGSELFKTAIAPNDHLVVKSRGVYKILEVHDSQCRGTVDKTASTFQVDWFPRPEISLIQTESITSAKDAFIKQDVCEGDIDGFEVKLQGSPPYHVSYELEHRSQQGSHSKSPRNFDAALSKASISMDTSKAGDYAYKFVGLADNLYNSDKKLRPLVVQQRVNARPTAVFSKPGQSFKYCVEEQEHEDKIPIALTGVSPFSVEVEIKHQSGSATDTYRIASINSNSYSMPIPREHLRLGAQQLRIRRVRDAKGCQQKYDVNGPSIQVQLFDAPSIYPLESREDFCVGERIAYTLSGTPPFDITYDFNGRWNAKSQTTNFRRVAEKPGEFIITSISDKASECRAAVNMHKKIHPLPSVQISRGKQSRVDIHEGNEVDILFEFWGTPPFEFTYTRSTNAKKGHKSVVLDRRHDISYEHSKVIKASQEGTYEVVAIKDKYCSFSTEEVSEKQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV02</accession>
    <name>A0A7D5UV02_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ace2</name>
        <name evidence="12" type="ORF">G6M90_00g043440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986391.1">
        <property type="nucleotide sequence ID" value="XM_066130324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV02"/>
    <dbReference type="GeneID" id="26240242"/>
    <dbReference type="KEGG" id="mbrn:26240242"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="578"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="689"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="817" mass="90917" checksum="A29F2FFFA0AA077A" modified="2021-02-10" version="1">MAQFRTQTVPHRQRISTDDNFQHPDSLATIMLPNSPTGVHARQRQHRRQNSTPSALEGVNISPLSNANNRRQAAAHRRGLSLDMRRHQTTPQTARQDFNQVRMATNNTGLANTSQHHVLPEAQQQRTQARPGPNQMQYASMVSNSNESFLISPHGTPQTQRFAPSSCFDTNAGRFSYPAHVDMMMRKNQENYYNNMAESASFDLFSNNSALSTPTFINFPDSPAGQVWPADDASSRRNSRRISDGIMDRVNKFEGMGIEEAQRPTTPPNQNGTNYYPPTPVETPQGRIFKQEARPGRFSDDYDESMEETIKPNRNSRSGLRTQSVFAHMRQQAEQNAGSLSPPVTNKISDAECLSGLQMQNSDYMNMNALRQEFVKIEDQNDAARLELDTTNSLSDLSHHTSPDTQNHGQFVGAAFEGKLDLQHFARLDSAAQSRKSSPHRRTESVASMASAASIADINIDETRTDTGVTLEEISQYIHSPETTDGKWMCLFEDCGKKFGRKENIKSHVQTHLNDRQYQCPTCKKCFVRQHDLKRHAKIHTGIKPYPCECGNSFARHDALTRHRQRGMCIGAFDGAVRKSAKRGRPRKRPDLETRREKSARTRKKNMSISSMSSFSGYSDSSAINSPDNEYNMLDDMVDLDIVSARTHGMPSMSTAPMPTLIPRVMNQDMAQSPSVVSAHSYVSPEAIMDTAPSHPASPAKSGVSHYNTPPPPELSQSSSPPPCHFFDLAPNTSSGADLAVMSSTNSMMGSSGMSGTLPMGMGDQDDDLLLQFSQDDSGLVQLDRDSNMLMLSKFDDEFEAAVSMFTNNDDMFFSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVC2</accession>
    <name>A0A7D5UVC2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">21.2 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g045910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544718.1">
        <property type="nucleotide sequence ID" value="XM_014689232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVC2"/>
    <dbReference type="GeneID" id="26242059"/>
    <dbReference type="KEGG" id="mbrn:26242059"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21033" checksum="A22170F93D001A33" modified="2021-02-10" version="1">MPNPWDYTYASPLAGFEDAPPLSTDTNDDGKSLVNPPRDGLSEAYRSFAWPLKTDRRGGFDIHVYYLQQNPEQAKYARELWERIRREFPELRVYKFWDRPIGPHPVAMFEVNVFTPAQFGAFVAWLAIWRGPLSALIHPNTTVHQGEAANEVELRDHTERAIWMGERLPLDWAPFRPQSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVC9</accession>
    <name>A0A7D5UVC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RAB6A-GEF complex partner protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Rgp1</name>
        <name evidence="2" type="ORF">G6M90_00g033740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543301.1">
        <property type="nucleotide sequence ID" value="XM_014687815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVC9"/>
    <dbReference type="GeneID" id="26244102"/>
    <dbReference type="KEGG" id="mbrn:26244102"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="829" mass="89587" checksum="1267E081871AB6C9" modified="2021-02-10" version="1">MPPDISSNIRVFVRWRDQTVFAGEDVKCTVTFKNVAPTPSQQQRQQQQSQQQQKPHGERQRLAVPLQARAKANVGLAAPPPTNATRGHRRSALSLSVSSTNSHSRSGSVQWSQATGSGGDWRPGHAHKRSLSIVSIGSANNAEDHVQRNESPSRPHRPHRGHSRAASLQISAQGATSPGPGPQSAPFFPRHMSSPLFNASYPPDRFGRLSGASTAPNTPGLGGQRRAPKSPARREMPNFRFPGGPSTRNAEAASPNLKSPDGLLSPRQVSPHESNGLAVRLKEQPQPPSAVDRPAARILASNTIPGGTPRSSGEFYSMSNNSSETLVSEYVTQPLARGNGRSPHTRRSSGMSPQQQKMPESLMMGYAQIQGSFILDGSLISLGPFEQVKKKGAVGGRGGGVVGLEQTKRDTGFLGSFGWGNISNSLGFLGGEELSTIKEIRGAVNSKSIPLLSTPQSILFVDLQLAPGESRSYEYTFRLPKGLPPSHKGKTIKISYSLVIGTQRAGGAKEQQVRSVEIPFRVLGSVNSHGEILGHDLMSPYILLRDAAEVKSLGKHVRMHKSRASFGPPATMNEFLNYVDDLASRRRDSTGIALLSPTESTAQRRPSTYEEVGTAKEAIHLAIMRSNMAGDGQQSANRFEIARNGQRVGVVMLTRPAYRLGEVVTMAIDFTDADIPCYAVHTTLETSEKVDSSLAIRSESSLQRVTRKVYVASSEAAMYSRRVVFTPTIPISATPEFVTTGVNLEWKIRVDFVVPYQGSDTTHLGELQVPHPLLEQISQDEKGGLVLVAIENLACESFDISVPLRVYGAVGSGLERLERDEASEEGLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVR3</accession>
    <name>A0A7D5UVR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylglutaconyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">auh</name>
        <name evidence="4" type="ORF">G6M90_00g044220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547756.1">
        <property type="nucleotide sequence ID" value="XM_014692270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVR3"/>
    <dbReference type="GeneID" id="26240319"/>
    <dbReference type="KEGG" id="mbrn:26240319"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="316" mass="33938" checksum="EFB3FDAB18480123" modified="2021-02-10" version="1">MPPRMSLSSPRATATFIRRLYSTETEPLIRVTNIPSASSGHIRVLELNRPKARNAISKALLTALRAEVDDVHAQYGPNGEETGVARPGVSANLGPTRALVLASAVDACFCAGADLKERRGFTQEETAAFLANLRGTFTTLSNLQIPTISAISSLALGGGLELALSTHFRVLSSNATIGLPETRLGIIPGAGGTHRLPAIIGLSRARDLILTGRRVAAPEAYFMGIADRLVEVVPQDERDASDILPAARKTTLAEAVRLAQEICEGGPVAIRAGLQAVAWARQEKENEMYERVVATEDRNEALKAFQEKRKPVFKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW11</accession>
    <name>A0A7D5UW11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">ALG14</name>
        <name evidence="12" type="ORF">G6M90_00g031950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543130.1">
        <property type="nucleotide sequence ID" value="XM_014687644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW11"/>
    <dbReference type="GeneID" id="26243931"/>
    <dbReference type="KEGG" id="mbrn:26243931"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI68197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="29816" checksum="94514280166FBA87" modified="2021-02-10" version="1">MVVTTIQLVSLLAGLISLAVYVTTRHIQLSQARRSRTWPKPPPFQAETRLPQNEYYLLVLGSGGHTKEMLMMMDDGTRDFGNSHRRYLISSGDKMSLNHVEDYEAELKATSENPGTYDTRVVTRARRVHQPLWSTPFSALRSVLDIFPVLLSPPKNEVGRQLKYPGIVFSNGPATGFFVALAVHLLKLFWVVPDDRLRFVYVESWARIATLSLTGRLLYYTGLADAFYVQHGEVAERYGLVNAGEMVFNSRRARQTRPGLDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW29</accession>
    <name>A0A7D5UW29_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septation initiation network scaffold protein cdc11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cdc11</name>
        <name evidence="4" type="ORF">G6M90_00g032000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543135.1">
        <property type="nucleotide sequence ID" value="XM_014687649.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243936"/>
    <dbReference type="KEGG" id="mbrn:26243936"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="303"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="362"/>
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        </location>
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            <begin position="422"/>
            <end position="458"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="811"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="886"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="997"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1052"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1108"/>
            <end position="1183"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1741"/>
            <end position="1768"/>
        </location>
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        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="237"/>
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    </feature>
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        <location>
            <begin position="475"/>
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        <location>
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            <begin position="607"/>
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            <begin position="653"/>
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        <location>
            <begin position="689"/>
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            <begin position="779"/>
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        <location>
            <begin position="886"/>
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            <begin position="1052"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1746"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1800" mass="199591" checksum="93EEF159E39114F0" modified="2021-02-10" version="1">MAHAWLDSLSEDWVSQPGSDASDGQLPPLPSPDEIETPQIKQFPSRIPRRAGNRSSLPSVDSNSPHVLSERSANDINVSIKRLPSKLSQEVSADVSRSISNETDGSVVHNRVPSQGSPDKNSETPEWKRRLVYGDVAYGEQRDLFCSAAVGLQDMFKPPQEGEEESGLGGDTSQHVDMTMPSSPPTYPQPVTDEDLDGFPDFDEDEEYPEDVTPSPSPRRLQKEIKYKLNESSPIPDSRKSGQPRVDDTLEHQTEHDISRDESCLTAPLDKEAASRKPSGQSDTRNEDFSPILIGKHNGTNGNVNFAPIEVPVDQLWQKLERLRVNQLLLDSQANHQAGIDASPRPPANMETTEDYIQNGGFINVRRGGRSGDGSFYNRGLSSELGADTSQMFPEESLQASTPKEFPSVRTLGTNPYPTFQITQSPSLPRAPFPSPEKKQLVPEQTRPPATSPLKLFGPYDTFTNQTLLRRISQFEETSGSPSQRSTTSDVIDHHPEDESALSASTLQRRNISKFGGGDLDGFEFQGDISDEIYEDSDVVGKENVAPNEPSLPSYPLRGIQAQDSSPDGYSGLVIERKRSKNETPSRVRDGETPISSNGASVTSGSPRRDLGSESKRPRTSPSKHPTPKRRRTLHRSDIAFGRESKEEAADTTHLQMHSLSSSKKRKDALPGNFEVADPNILASRPMLQPRSPTSSRGSSASYGQAQKSHLRNPANELPTPPSDAPTETDRKPSIRTQDFVDQAAQIMAMIRNQVQPELASLEESEEYIEAEDRRPSSGAESYQDSTSEPFSRPPSREGHPISWVPPRQDDPELANRLKQYEEFSDMGDVISSSVRSLGLAKNAMPASQDPTRRIDGGNQLRSNIMPIPVRGEVISDLPNVRITTNPLANAEQGSSSQEYPSHSSNRSTSQTYPSASSRGSESRRTIMPESVSHLIPDRVGSMCLDKDKKVWIKRKESVSVPECDILPSEDSEEDPFASIPDLSVDMTREMHNLRLATAGKEPAMDNPEERSSPRSPPRRVVSRGYVTLSPSQHMSPQDGAFTNEEVEKVEGLSDYRKGDSTTKTQAGHHRGSNAPSLTKRRNLTISFSSPIASVIRDISLEDLDSIEESDDRDEANNAEASTHRSPHRSSSQVEAKPRKGSQHVRANPSQAPLRQASFRGPAFIPRPVSRIDEQDEESTVELANEDRQLSVIGEQSMLNHKTPDGRRASLSFVFSQTPGNRALALSAEDSEFIGRNVGKLSLSPLSEFTLNNADHSFGFEVSYVMGPRHMATGDGSNKVLSMTIRELVDRLSEAEPHESFWEDLSELDLHDKRLASLHMLDEFCGKLVTLDVSGNKLNHLEGVPSTIRELKVSQNFLTELTSWDHLMNLQYVDISGNEVTSLSALKNLVHLRSIKADNNQLTSLDGLDAHDGLLHVRARNNMIEEVDFAASRFVRLEDLDLGGNRISSVQNLDMLPALARLKLSKNKLTALPMAECMKSLRHLDVSDNELLVLDIASFPSLHSIHADRNHISQVCGFDRTRRLDSLSLREQRGKTPLDLGFLSSAYEVRKLFLSGNYMREFEPRVDFLNMQLLELSNCGLQRLPDKMGQLMPNLRTLNINFNALSDLSPLQFIPRLKKLLAAGNRLADSTRVTQLLTEFPHLTRLDVRDNPVTLGFYAPLQVLVPTDGSGVADPFVLPDADVARDEMFASRLDEATRLRRRLHQVVLVASCGRLRMLDGLAVRRREVLARDQMLQTLINDGLVPDPERPQVQEKESEPIDANLNGPDAIDEETMADEQARAQLEEEAETAWHNTIHENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW50</accession>
    <name>A0A7D5UW50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADPH-dependent FMN reductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g048020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544919.1">
        <property type="nucleotide sequence ID" value="XM_014689433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW50"/>
    <dbReference type="GeneID" id="26242260"/>
    <dbReference type="KEGG" id="mbrn:26242260"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="209" mass="22790" checksum="A00A085230175AC6" modified="2021-02-10" version="1">MASKKTVALITGSTRKVRLGPFFTTYVRDMIAPHCPTLSLEIVDLADQGLPILDETNPAAGQPADDPTSHYEHEHTRKWSAVVRKYDAFIFVTPEYNRSVPAGLKNALDFLFHEWNGKPAGVVSYGGREGARASAHLRDILAALKLVVLPTAPGLSTSRRMLPYVGEHKSVSDDDRQRWKESGAEAQIVALAQELVAELEGASKAALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW82</accession>
    <name>A0A7D5UW82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PEX14</name>
        <name evidence="14" type="ORF">G6M90_00g036540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547045.1">
        <property type="nucleotide sequence ID" value="XM_014691559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW82"/>
    <dbReference type="GeneID" id="26239608"/>
    <dbReference type="KEGG" id="mbrn:26239608"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="156"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="239"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI67893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38053" checksum="789728D49CB1360F" modified="2021-02-10" version="1">MAIREDLVASAAQFLQDPSVASSTVENKIQFLRSKNLTQEEINTALARTGSPAPAGAVQYGSPAGPPQQYYPPYAQQAWQPPPPAPRRDWRDWFIMATVVSGVGYGLYSLSKRYVYPLIAPPTPERLEQDKKSIEEQFDKAFALVEQLARDTEALKDAEKQRTEKLDNAISELETVMSDLKSANRRREDDAQRIREDVQSLKDAIPKAMENQKTLADNRLSEINTELTSLKTLVSQRMAPSASPATGTGTSTTSSSFPRSSGSTLPAGRSSTSTATTPASATVESVPESSSTSTPAAAAATTTEAPKNPAQSFSRPPGLTSGSGSSTKASIPAWQMAAAQSASSATTEGSGKESGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW98</accession>
    <name>A0A7D5UW98_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF2A</name>
        <name evidence="11" type="ORF">G6M90_00g043100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547644.1">
        <property type="nucleotide sequence ID" value="XM_014692158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW98"/>
    <dbReference type="GeneID" id="26240207"/>
    <dbReference type="KEGG" id="mbrn:26240207"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="217"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="684" mass="74112" checksum="33628F33F0698309" modified="2021-02-10" version="1">MASPLQFAYRTQKAIGVFDAAPAYEPLAGFTKPEGNLRCSAYSPCGRFFGWASPETVTVVDASAGNVVLVLPIINVYELGFSPLGTFVITWERPAKDEAGDATKNLKIWRTVEDGVAGADKQPIGRFVQKQQGGWNLQYTADEKYCARLVTNEVQFYQSHDLVTVWNKLRVEGAANFALAPGSQNHAVAVFVPERKGQPAVVKVYNVPLFQNPISQKTFFKGDKVQFKWNKRGSSLLVLAQTDVDRSGKSYYGETTLYLLSTNGAFDARVTLDKEGPIHDVSWSPNSREFGVVYGYMPAKATIFNDRAVAKYSFPLGPRNTITFSPNARFVLVAGFGNLAGQIDVYDLEKDYRKVCTIESGNPSVCEWSPDSRYIMTATTSPRLRVDNGVKLWHVGGSIMYSEDMVELYNVLWRPSAPENVAGGDPLNPVPSPHASAAAYLGTVKTPSKPAGAYRPPGARGLATPLHFKREDEGGAAHFVSNGTQNVGPNGFGRPRRGVPGAEPAEPSQAAARVVPGAEPVGEDGAKKNKKKRGKKNNQEGRPEAEPNGGASLAPYDNRAPGSGRSPERRGPANGNGRDHRSRSRNNGGSRSRSNTQHGQRLNLGQQNNYYAQQQGGAAVAGAAADAGQSANAKKIRSLQKKIRAIEDLEMRLAGGEKLEDTQVKKINTKSAVLRELEGLEKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX15</accession>
    <name>A0A7D5UX15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanine aminomutase L-beta-phenylalanine forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cctP_1</name>
        <name evidence="2" type="ORF">G6M90_00g066440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539360.1">
        <property type="nucleotide sequence ID" value="XM_014683874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX15"/>
    <dbReference type="GeneID" id="26247838"/>
    <dbReference type="KEGG" id="mbrn:26247838"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="592" mass="64924" checksum="F54B0F194F52C60D" modified="2021-02-10" version="1">MPETLYLPKDKLGLSGEPYSMSDDLVRAIIAIRCNSLLRGHSAIRLELIKVLLQFLSKGMLPMVPLRGSISASGDLSPLSYLGGLLEGNPDIWVRYVKDGVPQLVTASAALSTLNIREIHLQPKEGLAIMNGTSVSVALAAQVVFDSNNLAVICQVITAMTAEALLGTPENYCEFISACRPHYGQTEVARNIRAFVAESSLCREGNSRGGLAQDRYALRTASQWIGPLVEDLQAATSQIQTELNSTTDNPLIDSEQSRVYHGGNFQAVSVTSAMEKTRTALVMLGRLLLAQSNELVNPYLSHGLSPNLVADNPSTSFTGKAVDINMTAYFCELAFFANSVASHVQTAEMNNQSVNSLGLIAARMTQKSNDLVSMMAASIMFLLCQALDLRARDMDFFLKARPVLLGLFHARCSAVITSECTQNQNLDTLFDALWASIQKIWAMNSRLDIQERCKQTIIHAADDLLNRDEYISVWNCNISLVTSLHYWKSEAAILFHSRFLDVDAEFCKCQSTSRYLAPFTSKIYQFIRNDLCVPFHLGFSDHPSIAQQRDGGSKPTRTIGFSVTKIFSAVQDGTLSSRIQVAMPVPISPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYJ3</accession>
    <name>A0A7D5UYJ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase sdnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdnE_0</name>
        <name evidence="10" type="ORF">G6M90_00g052940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986837.1">
        <property type="nucleotide sequence ID" value="XM_066130554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYJ3"/>
    <dbReference type="GeneID" id="26246782"/>
    <dbReference type="KEGG" id="mbrn:26246782"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="602" mass="66523" checksum="8D2BBAB69C193CD4" modified="2021-02-10" version="1">MDFTGASLVTVLLFGENLLRIVQTYATLETSIPAVSRLKRFGKKVPAESQEGVSVMVSAVWPTRSVIKINGVSASYVIGQSLIFSRRLDCYGRVHLLTTSSMALDISWPMVLGATVAYLATVASYRLFLHPLARFPGPKLAAISRWYEAYYDVVLGGQYTAKIAELHGEYGPIIRISPYELHVADAKFFDTLYRMEGRWDKYSWTYDAFGAKGSTVFCSDHHVHKARRRAIAPFFSKANVVDRQALLHRNVGKLCRRLSDLSGTAVNLGEAISAFTRDNANEYIIGKAYNELDLEDFGIGLSVASQGAGVFWRTTKHIRWFGPALRAMPVGWAMKMADERTKAFLRYIQQSEQDTRDTLAAEASSSPGAEVQNTMVHAIVKSDLPSAEKSFERIHEEVATVTGAGFETSANALRLILFHVYTNDAILGRLREEISSLTTESSGPITLRQLEQLPYLTGVLTEGLRLSPGVASRAARITDKDLAYNDWCIPAGTPVGMTTILIHTDQNLYPDPMCFNPDRWIDQGAGKAAVTKFAPFSRGTRICLGMHLAWAEMYLVLAALVQRFSFTIEGVAASDFELEKDNFGIGTKAGCNLMARVDPYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYZ3</accession>
    <name>A0A7D5UYZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g076730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545430.1">
        <property type="nucleotide sequence ID" value="XM_014689944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYZ3"/>
    <dbReference type="GeneID" id="26241463"/>
    <dbReference type="KEGG" id="mbrn:26241463"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="40"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="392" mass="43762" checksum="57C10A0AA6C0DFC5" modified="2021-02-10" version="1">MERPKSVFTPDEPGALPLDQVLAQVINDDQEEWEYEYSATETETFYLTVELSYPEFKERAARIPQHSRGGYYRNWAEQDAPRETPKPPPQEARPAAGDNSDNEEITAEQDYEDDGTPLDPALLAMSNGKGKDKATTPLPADTPKHQEGAQPAQAQEEPLVTEDIQVLDLHTPSPLFSYRGRLFQGHWAEVIGTEVILAGTPPSDDSAALPSLRTLPGDISLLAASSSRIMTSEKMPRPKIPAVDKLAPIKEEWNIRIPRAKDKTGERAEQVNFLENLMAFKIKKGNKDQVTVYATDGKGKDWDDKKSVSYRPRRKKIGEEHDAEKPKKQVGRRPRGRPSLATRLEGYPVGFGEGATRHIELSTMTPTRWDDLDREDADEEGSEDGEDVTMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZN4</accession>
    <name>A0A7D5UZN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase BOT4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BOT4</name>
        <name evidence="9" type="ORF">G6M90_00g055560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544151.1">
        <property type="nucleotide sequence ID" value="XM_014688665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZN4"/>
    <dbReference type="GeneID" id="26242563"/>
    <dbReference type="KEGG" id="mbrn:26242563"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="519" mass="59144" checksum="90767BCBD3FC12A7" modified="2021-02-10" version="1">MVLLQLEAMWQSDTIKHMRLLTWYHWFLFATIAWIGQSIYRLKFHPLRRFPGPRIAACSSLYFLYWIYHGTFPQHCERLFDHYKSDVLRVAPNQLVFRTPQSLKDIVGRHDVYRGDFALRVIGFTSQNVSNIRDPAAHKRKRKLMNPGFSNVTLAKQEPALVVPLVNKLVDAVAAKAGTKINMSNYFDCVTSDIIGLLSFGADFGMMQDPVSHPFLHVLPNALRMSVIAQCIPEIFRLLSFLFRHGPPFIVPKTFTGVADFAARHMRQRAQRDRDGVATDRNDIMSIIVDGTANVKDDNLRMDNNEMLGEATTLVTGGGDTVATALTVTMWNLGRNTKVLAELQDQVRSAFASCEEITSRDVASKIPMIDAVLNESMRTNPVLPGPMWRRTDAPIVVAGHVVPGGTEVGVMRLSVFQHKDAFHKPKEWIPERWLRNLGDHLEAFQPFGVGPRTCIGRYIAMVEMRLILTKLLWKFDWELLTKDYDNPEYVVLYRSPLWMKPSLRKDSMAERPAQIHKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZY0</accession>
    <name>A0A7D5UZY0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g073910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545674.1">
        <property type="nucleotide sequence ID" value="XM_014690188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZY0"/>
    <dbReference type="GeneID" id="26241707"/>
    <dbReference type="KEGG" id="mbrn:26241707"/>
    <dbReference type="OrthoDB" id="3518533at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028923839" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="229" mass="25390" checksum="9E02976D8CF6CF7B" modified="2021-02-10" version="1">MKKVLLALAFLGLASASPNEAAWPETTHARGFRLVVNVTHPSRDFNPPVHNTYITGVHYGERTDAVVPGQDFKNARIFFVNGTQGEADADVATTIWADWDVYESWRLSPEPGSETLSEVLMSGADGDKGIGIRHYKSPFVFLTPETYVACRQVLPIGGEQVVIKQAKTTFPPDGSPNYNIPRDCAPVRLLPECAELLPLSPRARFDYRFAVQSQCYKNVTGIDWAKYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0K0</accession>
    <name>A0A7D5V0K0_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g090790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541737.1">
        <property type="nucleotide sequence ID" value="XM_014686251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0K0"/>
    <dbReference type="GeneID" id="26245600"/>
    <dbReference type="KEGG" id="mbrn:26245600"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="68" mass="7395" checksum="A5F94DCB0B78B7EB" modified="2021-02-10" version="1">MDKVKEAVNKATSSSDSEKQFTTQPVQHGIDPKVAPHQAHPGPALTKDMPSEEGSKAEREARKKELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0U1</accession>
    <name>A0A7D5V0U1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell wall integrity protein scw1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">scw1</name>
        <name evidence="6" type="ORF">G6M90_00g090170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541675.1">
        <property type="nucleotide sequence ID" value="XM_014686189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0U1"/>
    <dbReference type="GeneID" id="26245538"/>
    <dbReference type="KEGG" id="mbrn:26245538"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="375"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="564" mass="60062" checksum="6FE053D4D5E3BA0A" modified="2021-02-10" version="1">MTPDPCAPPSQQPNLISGASAKPQLSNRSSPFPTITTASDKISSMAAASSFLPAAQTFRPSHSTQSPYPLNMSTAHLFEREPTKPVGTPFSSTPTPMVRVLIRRLPLNTSEESLRLMVVWSKELADVELLPADKSEDDGFRSALLRFRSMAGAQEAKTMLDGRSNISNDAEMIVEVLSNSPPIARRNTVEQASAMPPVTSSTGPAPVPASRQPARFNGFQPLDNSVSPTSNSVFPAHEFIHPDANSHYQSIFSPQSPIGNHLSERPRISGKSLISSDFGDDDETSDLLKDPVAYAENGATSQRRATAPQIPIGRMAGLSLSTNPSQGPASLPPYMTPLSPANAPAPGLGYPVNGHGFPRHNFPPVNPADQNPPCNTLYVGNLPIDTSEEELKAMFSKQRGYKRLCFRTKQNGPMCFVEFEDVSFATKALHELYGQPLHNSVKGGIRLSFSKNPLGVRSGQAPGQGANTSMGNMTGMMSNGTNGFATTHGPPPGLAAPPGLGSGRGNYNLASSMNTGGSRPYNAAGFPGAPTHPWNTPYNNSVATGPNSGLNNNSSYFPRHMMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0X1</accession>
    <name>A0A7D5V0X1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reticulon-4-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RTN4IP1</name>
        <name evidence="2" type="ORF">G6M90_00g089720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541633.1">
        <property type="nucleotide sequence ID" value="XM_014686147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0X1"/>
    <dbReference type="GeneID" id="26245496"/>
    <dbReference type="KEGG" id="mbrn:26245496"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="359" mass="38225" checksum="F5AA60CFDB9AA6D2" modified="2021-02-10" version="1">MATMQSINTTAYSDPSGYRLSSLPKPEVSDPGDVVIQVHAASINPIDVKKAAGAMKMVLKDSFPYKVGYDCAGIVLAVGETVTRVKVGDEVYIRLPESHRGSWSQFAKCPESYVALKPASLSFEAAASLPLAAMTAFQALKKYDGSLAGKTVFVPAGLSGTGSYACQLAKNVFGAGKVITTVSTSKVARVPELLGQGVVDEIIDYTQANPAASIPAKSVDFMLDTTGQAMEFLSRMVPETGLVVSISTTPSGKQMQDAAVTRSSDSGKIPFVASTVLNTLDSMRKWRAKRWRVSYEYMFLDPSGADLDALREHVAAGKLKPVVGLTVKFEDIEAVRQAAMTSYQGKGGIGKTVIKMDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1A6</accession>
    <name>A0A7D5V1A6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g092990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541943.1">
        <property type="nucleotide sequence ID" value="XM_014686457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1A6"/>
    <dbReference type="GeneID" id="26245411"/>
    <dbReference type="KEGG" id="mbrn:26245411"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="24262" checksum="9AC45EE74BCE945C" modified="2021-02-10" version="1">MPSLHVETKNLADPTSPAEGQGAASQPALSHQHEHATSPRTIRAPPERLVEGDLVLRRWKLSDAADLHAAASSSAVELARWMPWAADGYDLTKAQQFLDFTSKAWDNGESYDFAIIVDGRISGSFGLMTPATKAPNTLEVGYWLAKEATGRGLATRAASLLTRTAFAVGAEHVQIRHDERNHRSGAIPRRLGFKSLGLESLPAGKRGGKEVSLLWQKDVDSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2T5</accession>
    <name>A0A7D5V2T5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g093670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540736.1">
        <property type="nucleotide sequence ID" value="XM_014685250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2T5"/>
    <dbReference type="GeneID" id="26246349"/>
    <dbReference type="KEGG" id="mbrn:26246349"/>
    <dbReference type="OrthoDB" id="4937825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="38498" checksum="B867B2D1222AF328" modified="2021-02-10" version="1">MAQYRDSIVACTVILLIANTVAVAARVYSRLRITESFGADDAMLCLTYVGYILLCGMSFTALHYGYAAEDDTPYSTLQPYYNPEKAKQFYFANQLVIYIDSGLIKLAVALVLMRIATTKAMRWLLIGSMGVVVVWTTVMTIYSSYLCAKAGTSNYAGSRTCNIVGYFRTTTNILIDYFYALLPIYILWNVKMRLLLKLSVVFLLGLGIFASASTIVKLIIIIRLNHARGDEAEHLHYQLLLWADAETGLAILAASLAAVRPLLAKLRIPGLTKHSTNRSSLARKPQVNDSDAMGPYREIHDGNPLVQSGTNASKSHVHHHEVTDIESLEMRPLESGTLGVGQHGSRGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3A4</accession>
    <name>A0A7D5V3A4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30-kDa cleavage and polyadenylation specificity factor 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CPSF30</name>
        <name evidence="3" type="ORF">G6M90_00g098500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987586.1">
        <property type="nucleotide sequence ID" value="XM_066131546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3A4"/>
    <dbReference type="GeneID" id="26240917"/>
    <dbReference type="KEGG" id="mbrn:26240917"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="399"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="627" mass="69270" checksum="DB924A81B27C9242" modified="2021-02-10" version="1">MQSDSVSRTQDAGQLDAPRQTPTFLSANPNSNSDEASELPPAAVEQVQHQYPYQPGPLQQTPAQATMAYQQPQGHQEAFDLAPMNNTLLAINYRPQYSTQYLQGHSQPFSSTTSPPMAHQMTPMPQYGGAAIPMPNQAYYVQQQQIPQYYSTSHLSQVQHPIPVQGRQDMVYYHNQMLMSPAQTSFYYPHNGQYSGHPPAMPTMVSGVFVDGVSKSQSRSPPHQANGNVAARRPYDQDAPSATQNTVRGPPRKPRQSGHALWIGNLPPQTNLMALVHHVYQVTPGMESLFLISKSNCAFANFKDESACSTAQQNLHDSKFQSVRLVSRLRKSAVEGSTGSTVPTGPAVNSTPSKTQGGIDIESVNDDSEKKNPPTESELVAKLALPVARRDSKSHQYEDKFFVLKSLTTEDLDLSVQTGIWATQSHNENNLNDAFQAADNVYLIFSANKSGEYFGYARMISEINEDPAAAIKFAPKVASTANVDLPIAIPTDATEHAPRGKIIDDSARGTIFWEAERDDSETESDMESESTSDNANGTEDETKTWGKPFKLEWLSTSRLPFFRTRGLRNPWNSNREVKIARDGTELEPAVGRRLIGLFNRVQNPTIVATSARAQMNFAPGYPMMRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V438</accession>
    <name>A0A7D5V438_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g111240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543738.1">
        <property type="nucleotide sequence ID" value="XM_014688252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V438"/>
    <dbReference type="GeneID" id="26243125"/>
    <dbReference type="KEGG" id="mbrn:26243125"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF87">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028945837" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="98"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="40538" checksum="811154DBE6343754" modified="2021-02-10" version="1">MARSLLLLTILSLTTGLSVARRCQNITIPISISSRNGVFSLATPANDVDVTDFVLNNFRAGVNYTDDVLQGYKTIQANYNLAATYCTPESGHGKSLQVLTHGVGINRYYWDFSYNNYNYSYVDRALAQGYSTLIYDRLGVGESSRGDPIQELQASLEVSALHQLTKLLRQSKVPGIKTKFDKIFHVGHSFGSILTYGLTTKYPEDSDGIVLTGFSIDETFFAWFGYASNWVVANSNPALKQFPNGYVALGTAQAFQAVAFAPSNFDLALPAAANSIAQPIPIGEILTIGSPQEVSNPFKGPVLVIDGDRDLIFCGGNCSSSTPSAAELVRPKFTKVTDFEAVIVPQTGHLLNFEYSHPATYSAIINFLNRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4G2</accession>
    <name>A0A7D5V4G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g106620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539878.1">
        <property type="nucleotide sequence ID" value="XM_014684392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4G2"/>
    <dbReference type="GeneID" id="26247317"/>
    <dbReference type="KEGG" id="mbrn:26247317"/>
    <dbReference type="OrthoDB" id="4941021at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="123" mass="13455" checksum="85012232819208E9" modified="2021-02-10" version="1">MPVLAINSKDEQDLVKVIASNKKVVVAITSPGLAHCDGVEETIKELSKMQQDIIFVSVDHGEFPPNVGDGGNYMVPWVTMYKEGKKLDDWNFSSSFTLVERIEAFATDRPLASAEPLQKTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4V3</accession>
    <name>A0A7D5V4V3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g106660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987992.1">
        <property type="nucleotide sequence ID" value="XM_066131709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4V3"/>
    <dbReference type="GeneID" id="90968218"/>
    <dbReference type="KEGG" id="mbrn:90968218"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="15003" checksum="1883ADEE4FE6D721" modified="2021-02-10" version="1">MEAWAQNSSISGLRLRRQHGYMWSGTGIVGVSSSLLMSLLAEYTDLDILSWQALGRDSTEAAQGDICIHTGRLQATSLAGSRNYNLPNQCHVPATEAIREQRKSSRQQHKDFAPETNPVPYGVHYVYPRLRQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V538</accession>
    <name>A0A7D5V538_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g100440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546305.2">
        <property type="nucleotide sequence ID" value="XM_014690819.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V538"/>
    <dbReference type="GeneID" id="26240728"/>
    <dbReference type="KEGG" id="mbrn:26240728"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="574"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1128" mass="124450" checksum="33C56A6710099058" modified="2021-02-10" version="1">MTTSKSFRASMLPSSLSFPSFRSTSNTDCNANSKSKSNSHPSPDPEKSKRRTLWHKGTTHLPMRRPLPARDLKEESKSATATTPAPAATNLTKEQQEQQGQQEQRDPSPAQPLPSPHFQKTPSWALRLSSLVPLLTPDTADTHPVSVNRKPVAVNMIPPPQTPPPPPYVASEAEDERSGSRSRTTTSVEASGSGEAAVHPQESPRAQIRAQIRTVPPIPESEPPEVPEFAISFSTHQTPEILAPIPPSPDSHHAALTKQEPAIQPDAWRVSGAADNENESQKQAKLQKDNYKPRPRRNSLFQPKLPEPQPGNIYPRQMSPNPESRGRKSVSGQMSLAPSGSVSLAPNSRSASSHDGSQSPTRAKLRRSWLPGGARSRSNSEVTNGVKPEAWIMSEDTHAEYNPSFLKNGEKVPELWNENGNVYVYLYPRGSGYGPSFKVPEFVVGTSYVFNELIYTEQNAESPGDRVSSFGGRDNLSVHDANRIASPSIGPSMAEEPNALRLYIPAAPGGGAPAELGRLIAIRNLFAFLTGQPLVATKAHPTIFHAFVELAGLLLEFGFSGPDGSTFGEAVELSFGFYLEQLGISDCRHSREKTIESLILGERMRCVELYNEAFAHAAGKYSAIIDLRLPLFEQVSPLTRQRLERAHLDLVNRQHNVNEHLEQFEFPSLFAGIANSTSIPELRQVRFKTWRNSFSRMRQFLLNYYKSTFGNWPPKASNKKNPFAESGLNRLVLKVLYSDMCALYDLLVDRNSLTSRVMDETPAISDEPSKMTISALRNILSEFDRSKPPVLPPIPFDLPQLPSMKAIHETFDNMSQKDQNRMEKKIKEHELILILNKAYNYDTNRIKLPFLDHFKDFEIREGKGKVTHDLVDQRIGYWLFLYVVLQSLPMLVVDAPGVKHTEGVEYFLCEPPMGNLPWIEDGQVRKMWYEVTGGGGIVELSADAVMFSVEATYHRSHCWLAAKQWEGLDGVDAVPPEEPPMSPLQPPQPMFPGEEPAMNSPPVVGGPSTPSPPPGGPQPALRPRNLSPAHRSRQYSRSSIAMGLEPVPMEPPPNLFGGHNRSSSIGPRPPSSHLGLRSASVGNLAGMTTREASSVSQTKPAATTGATFDDILGETKKKPVAKKKGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5L6</accession>
    <name>A0A7D5V5L6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Alg12</name>
        <name evidence="13" type="ORF">G6M90_00g099310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546415.1">
        <property type="nucleotide sequence ID" value="XM_014690929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5L6"/>
    <dbReference type="GeneID" id="26240838"/>
    <dbReference type="KEGG" id="mbrn:26240838"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI73819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="547" mass="61009" checksum="CDE7B73E9D2498DA" modified="2021-02-10" version="1">MALVDALLTSLIFILPTVHILIAPHTKVEESFNLQAVHDILIYGTPTSNIHERFRQTYDHFSFPGAVPRTFIGSVLLAGLGQPVIALVGFQHAQLVVRWLLCLFNASCLLVFKNAVQQAYGKGTGRWWTALMMSQFHLVYYLGRTLPNMFAFGLTTLAFAFLLPKATRRQTVVRAKQALSILTFAGVVFRSEIAILLATTTVYLLLTKQLPLRTVILVGAISAAASLLVSVPIDSYFWQKPLWPELWGFYFNAVQGSSSDWGTSPWHYYLTSALPRLLLNPLALLLILFSTFHPALYRQNKALLLPSLSYIAIYSLQPHKETRFIFYVVPSLVLSASLSANYISTHVSKSPVYKVATFTLILSILATLSASTGMLLLSSLNYPGGEALSQLYGLTDKAATPITVHADVLTCMTGLTLFNQNKHGLPLALNDSWGVEAPGKTVYLFDKTEKSEKLGWPTFWQQFDYALLEDTALALGEWDVVGVVYGYSGIELLRPGQREVEDKYRALGLGAKMRWMRGVVRKYTGGWWVGPRMAPRIHVMKQRRIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V707</accession>
    <name>A0A7D5V707_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rho2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rho2</name>
        <name evidence="10" type="ORF">G6M90_00g110690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543790.2">
        <property type="nucleotide sequence ID" value="XM_014688304.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V707"/>
    <dbReference type="GeneID" id="26243177"/>
    <dbReference type="KEGG" id="mbrn:26243177"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000573">
        <property type="entry name" value="RHO family GTPase Rho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="200" mass="21999" checksum="17D4FBDBEC414F3F" modified="2021-02-10" version="1">MASSNSQNVIRRKLVIIGDGACGKTSLLSVFTLGYFPTRYIPTVFENYVTDCRVDGKSVQLALWDTAGQEDYERLRPLAYSKAHVILIGFSVDTPDSLENVKNKWIEEATRLCAGVPIILVGLKKDLREDPVAVEEMRKKSQRFLTTHDGEMAAREVGAKRYLECSSLSGEGVDDVFEAATRAALLTFEKGEGGGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V7B7</accession>
    <name>A0A7D5V7B7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g111080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543754.1">
        <property type="nucleotide sequence ID" value="XM_014688268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V7B7"/>
    <dbReference type="GeneID" id="26243141"/>
    <dbReference type="KEGG" id="mbrn:26243141"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="152" mass="16360" checksum="24CB32A731E70987" modified="2021-02-10" version="1">MSQLPGRMGDYQVSAPGALAAAAARKKGKKYAAKRQQQRSTCHNCGQLGHYARDCRLPRRPAAAAAPLYAGVVNNFFFSGSAVVHGPSGTMSPGGPPANSNGGVKKNKKKKKAKAKKAELAKKAELAKKAEEEEEEEEDKKKVKEEVDDEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKF3</accession>
    <name>A0A7D5YKF3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cdc3</name>
        <name evidence="8" type="ORF">G6M90_00g024510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985589.1">
        <property type="nucleotide sequence ID" value="XM_066129941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKF3"/>
    <dbReference type="GeneID" id="26237575"/>
    <dbReference type="KEGG" id="mbrn:26237575"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="139" mass="14398" checksum="D789DD8EADC1FFFC" modified="2021-02-10" version="1">MSWQAYVDTSLVATGHIDKGAIVSAAGDSAWAASTDFQLKPEEMKAISAIVSGDAAAKDKAFAEGLYIAGSRYVMARADGRSIYARQFGFCFCGQGRLGVAIAKTKQAIVVGHHGETGVAGNASSTVEGLADYLIGQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKJ3</accession>
    <name>A0A7D5YKJ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g020180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985615.1">
        <property type="nucleotide sequence ID" value="XM_066129851.1"/>
    </dbReference>
    <dbReference type="GeneID" id="90967484"/>
    <dbReference type="KEGG" id="mbrn:90967484"/>
    <dbReference type="OrthoDB" id="3548913at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1366"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1533"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1807" mass="200875" checksum="DA62622BEBB1DEA2" modified="2021-02-10" version="1">MISMQRSLSSPVLTQSPASVPASPTRTPGSPSPSPAEDQKDVSQASCYRSRTPPRSPEVSQQTLPLRHTDGGNRWSYQRTHSGLTTSRRPLVAQPDVAVQTNDRCNSNELLTGPQIEPPSERACRRPCTQPLIVDVTQYTNPHLTKEDENITLQELAHVVRLSKYQERKRANTRVRLQRSLISTALSARLTRCGDIANRNLVESFRKDDKDGFAMLYNAIQDVRKSCDELRRYALLEPDMEPLSSPALGSSESLDTPTSSVVGVAPLRPITPFLHDISATSRDTILDFLSELRTNPDYLATRICALSSSELNAFLGFHKGMEPVESVLPYHGRSASRHHAGVSSSRSNASSDIERLLSFQRHDPLSILIHSCFANSAGPDSTEDQRRTDIWATTLARLIQQPKSSSEHFLVSVLNIWTGMRDWSGKSNMEWYLMKILEEGAFILDRAEDQHGTRFNLSDWNSSDEVAAKEFYDRAVQGLFELIDDEDATGIPEGLLELGNAIVKKLDNKYVENTSRWLVWKCLFFGFLLGVIVHPESHGMLAEYHITPYARETILKKVAMKAYEYVSSMWSGKPSATCVPVEVPPQIKDHVERILARFQGSRSKTLSAKLLPARSITSLRETVEVHPYLVLSPPDLATLANALFPERRPMSSMSNTLRSGAASISGLSAISQQVPTPNLRNSNLETASIISTSFSSVISDGTTAPREGSQDGQPHTPSQRHSPPSADPDAQRKLANYEDDGYRLGLAMHELSQNLGPEALKGTFHPCAERWIILFLSPDGKKLSTSMTYDPEDEADEDDNSSSTDTDEDEGTKGPELDKDYHQIRDAILRLVEEYEIPRNLEAEGDRAPQLTNRASRLRRYKSKNKIITTEKSVSRRNPYRTHDGNSRSNNASLGDSAVPDSAFRTAWEEDEEPVLIKMLRAASSQSKAQADFVSAHVYWKTLKNLCALESPSLRANGFAVLINIFSRGPRDSIRRSAAAIEEYDAWLVWLKQSQERHEGSIDRMMRRVRAMRDKMWFVADVRNSKEYGHSRDICQALKTMGMPRRWSSIQRSRANVGRAPGSSYLYRTESQIMDLLAASEEQGGPNKLSDDQAEMTSNWLQQYGVENFCYGEERIHRFCCEVDKCISKLVGETIRDAPVLWSSDLYKREKVVYDRIRVRERDQSWSGDDTASILSDGERRLGSPSSRPSWMLREPERGRFPNSPNGGQHALDMPRINFARPTASLSDVVENHDAFEKSSPVNTVDSMSTFWSPFKPVMTPGSGVSRAYSPTTSLTNVSTTFSGPLHHFPLPSSSSVSTGRPGTSATSNETIFQQRAEDEKSRFLNELRQTLTSLLLSDLGNQVLARGSETDAWFHVLGQQLIDRKDAHDHARRRSERKDKEVGGRSSTRPRVIEKKKSFKNLRNAGDNASERSADVPLVGMADEADTTGTGNGSKAKEATTDFPFKKAYHRLLSMFSVNPNPFAKLNALNELENLIIASLMWHGSKKLRANLSDAGSSTASDRGPYNHQTPLDGTIDNVKERRSQAIQSVFHPAGYGNQPRQANAETKSISSGSSSTDAITSELQRLFRDAGIRPKSLFRDLQLIAAFVPSAILDKPERGKAFWNVGLAALKLKSEVCRTMVEIADNVIEVHTQHRKLVNDSHILSESKPSVTGTPPPPPTIYNLHDVGKMCVITAREGYPAAQRELALLYMSNPECVERTTLPLSKPREVFKQAVMERYGRSERTRGSSGAAGPAGLANASMNMRAMGPAHPAGDGPALGGKDSDARNDAGLLCIAIHWMKSAEQGGDETAARFFQQQDFKWDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YL12</accession>
    <name>A0A7D5YL12_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g017610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548769.1">
        <property type="nucleotide sequence ID" value="XM_014693283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YL12"/>
    <dbReference type="GeneID" id="26238213"/>
    <dbReference type="KEGG" id="mbrn:26238213"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF6">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G00280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="310" mass="34286" checksum="B1B8768E16041CEB" modified="2021-02-10" version="1">MDSVLVIGAGELGLCVLQALAAHPKRHHVKVSVLMRQATLDSAAPAKKRTVQRIKNLNVHFESADVVLAGVQELAGIFTNYHTVVSCSGMELPGGTQTKLAEAALRARVRRYLPWQYGMRYDVIGEGSSQDLFDEQLLVRRMLRAQSETQWVIVSTGLFMSFLFAEDFSVVDLRRGVARALGSWDNRITVTAAPDIGRVAAEVVLDPRGVGNEVVLTAGDTVSYGELADLLDEHFGTRFARELWDADTLRGQMAEDPSAVVKYRDVFARGRGVSWDKDRTLNFERGMELLDVKGYLDSVNFKVGEAWPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMB4</accession>
    <name>A0A7D5YMB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g022050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548347.1">
        <property type="nucleotide sequence ID" value="XM_014692861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMB4"/>
    <dbReference type="GeneID" id="26237791"/>
    <dbReference type="KEGG" id="mbrn:26237791"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="10"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="325" mass="34383" checksum="B67066A62DE510DF" modified="2021-02-10" version="1">MKGIRVRQTGDSSVLRQETDLAIPAIGDRDVLVKVEYAGVNFIDIYQRAGVYPMPLPFTAGREGSGTVVGVGPHVRPTTDFNVGDRVAVFTQGTMAEYVSAAASGVAKLPPSVSTQSGAAITLQGLTAWTMVRDAHRVEAGQVVLVQAAAGGTGGLLVQMCKHLGATVIGTVSTQQKAQVARKHGCDHVILYKDVNVEREVDHLTDGEGCHAVLSGVGAATFEADLACTRRKGTLVSYGNSSGVVSSFGILALSKRNVKLVRPTLANYITEREEFEERWQELSGLVSSGAVKIELGGMYTLDTLGRAQDDLASQLTTGKLLVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMZ5</accession>
    <name>A0A7D5YMZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g020520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548494.2">
        <property type="nucleotide sequence ID" value="XM_014693008.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMZ5"/>
    <dbReference type="GeneID" id="26237938"/>
    <dbReference type="KEGG" id="mbrn:26237938"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="45039" checksum="EB49B7345D20D5B9" modified="2021-02-10" version="1">MATYAVENAIPHGGAWGRSAPITPVPIPACVAQNAEPESDACWFWAGVPPALQDLKFTLPLQNTIFSVMHSTGKPSYWIEVEDWHTAGEPFRIVDKLPAGHLPASPTVAQRRADITATPGHPLDELRRLLCHEPRGHGGMYGGFITPPDDSGAHFGVLFWHRNGFSTACGHGTIALGYWAVFHRIVVVPDADGVVDVVVDVPSGRVVARMAIEKGKPVHADFINVASFQLTGPLYLTLPSCGIDVLVDLAFGGAVYASLDAAQFDLEIEPRSAQRFVQLAREVEAVLGTRARYGSYDLYGVIFFSEEENGPNATHAIYQRNVTIFADGEIDRSPCGSGTCARLALLFAQGKLGPGSSRLVHRSIIASTFEADIVSAVASPVDGFPACIPRVRGRANLVGQTRFFIDPDDEVFPGFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNR8</accession>
    <name>A0A7D5YNR8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g012600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549263.1">
        <property type="nucleotide sequence ID" value="XM_014693777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNR8"/>
    <dbReference type="GeneID" id="26238707"/>
    <dbReference type="KEGG" id="mbrn:26238707"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="698" mass="76512" checksum="1526786027889BBA" modified="2021-02-10" version="1">MPWKPATGGNGQKPRAASSKSIRGHISGPIPIPDPMDEEFPMRDQTATVARNADEASSDSHLIPPEPSSNRSYKASHFRAVSAGNIDPLIAHQRQHPLSAPRRASTLRGSSVSQHDRFTRISDQADGRDSKASKNSKPQRKKSTIRSALGKLFGRKKKSETNEKAGLPDWKASDASTLLSNKQHRSDPTWERSNQMSIEPKRSFSMPITEFDRALRSHSIGPEDVMAITSVRNSISADVRMSDKNVAAFEPSTHLASPRWAGGSKLTGLSPRPASSQDRGTRMAGLGDDPSEIGRAISSEAHGLKRRSRSLSVMPSLELASQGVVRRRSAEIRYWRESYAAPFMSPTSTTADEEIRQLLSGDTDEFTSSAEQRVVTPEQTVLMEAAEAKEVQTPTSTKTTEPAGASERLSLDSRVGSLETRMSRLESIVLQLGQSIPALRQPSTTQLRSSGGPRQAQLQTPDHIIHSMRIQPGDFSLADEHRQSTSRPSTRHSDASKMTFGDISDSTPRATILSPVDGEARPNFLAAPRGLDATSKSRHGSLTFEHYTNLMALFETERSAREALEAQVRSLGRQIQVMSKSMVYTNADQSESPSLDRSLGEVSVFDYDDEDDERRHFAAPRFGFTSLGMEDSGTTAEDGSDKEYTESFVTPVETSKSSFDMYGNENDPMLSNGRKLSLSHLTMKQPLTTMPQVATKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNZ8</accession>
    <name>A0A7D5YNZ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PRE2</name>
        <name evidence="12" type="ORF">G6M90_00g012860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549236.1">
        <property type="nucleotide sequence ID" value="XM_014693750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNZ8"/>
    <dbReference type="GeneID" id="26238680"/>
    <dbReference type="KEGG" id="mbrn:26238680"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 11 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="283" mass="31142" checksum="50DA1956BF82C460" modified="2021-02-10" version="1">MDTLVSRYSRPAYEQNEPFENEAQEMMDATSSLTTKFAMPPISQPSSWLRAATDDRSNPDCPIKIAHGTTTLAFRFQGGIIVATDSRATAGNWIASQTVKKVIEINSVLLGTMAGGAADCQYWLAWLGMQCRLHELRHKRRISVAAASKILANLVYSYKGMGLSMGTMCAGVTKEEGPALYYVDSDGTRLAGNLFCVGSGQTFAYGVLDAEYNYDLSVEDALELGRRSILAATHRDAYSGGFINLYHVKEEGWVKHGFTDTNPVFWKTKLEKGEFSNVTSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPF6</accession>
    <name>A0A7D5YPF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trm6</name>
        <name evidence="8" type="ORF">G6M90_00g033160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543245.1">
        <property type="nucleotide sequence ID" value="XM_014687759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPF6"/>
    <dbReference type="GeneID" id="26244046"/>
    <dbReference type="KEGG" id="mbrn:26244046"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="579" mass="63763" checksum="44FF7599D646D239" modified="2021-02-10" version="1">MSRSVVQPNSWVALRLPNDALRVLQVAPNTTISLGKYGSFPSNLLMERPFHLTYEVQEKRPGENFSRLRIVPGAELNADILAETNENEQTDGDAAIVVGEGEQLALVDESGKVVARSNREIIDDSARQTLTADEIEVLKREGASAGKELIAKLMLSHTAIDQKTSYSLAKYKLLKERKFLRRFSVLPLDVVLLGQWLLENRDAWKVLELRPEMMGLLGCWADVHFGGEPAQGVREPHGGRWLAVDDTGGLLVAALAERMGLLHHEPGEQAASPGPGEEEEESRPAAEAAAGQNGANGGPEQQQEPPSSPQAQRTSKKRPRCRDFDDHFALTNTITLIHSNSQPNLSVLRYFDYDAGDPNPTYPYHPLFTNLLPISWLQLVDPAQDVVCSEKPADATPEELASWKPNRRGNYHRKRRRWARTNEVIENTRAGGFSGLAVASTMDPVSVLREALPLLAGGAPIAIYSPTIEPLEQLVDCFSIGRRAAWVSSLPAEAEGKTQAELDRWRGTREFPINPTLVLGAAVQSSRARRWQVLPGRTHPFMTGRGGAEGFLFTGWRAIPAQGRVSARGKFQKKRGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPK7</accession>
    <name>A0A7D5YPK7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g011920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549330.1">
        <property type="nucleotide sequence ID" value="XM_014693844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPK7"/>
    <dbReference type="GeneID" id="26238774"/>
    <dbReference type="KEGG" id="mbrn:26238774"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="443"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="728" mass="80685" checksum="E274F1A6DD8BC9DE" modified="2021-02-10" version="1">MGRRPTPQPLPLGSTKANTSANSIRSTHNRGHRLGATGATAAAATGFGLGATAQATRTGTAACIESTAETAVQTANVSPIHPRPPVSLQPSLPLSLQSQPSQHSLQSELSQSQSHSRSQPSVSLTSRFAATKRPQTSQASQTGRGHMLTLGHETNQPRPPQLQLQHEQSPPYHDQISGSASPAFRQVTSDAEKRPSTKSGFFHFNKSSKSSNQLPQNPCPQLSDSQEYLATRGPEEPRAPKSENFPYTQEYLQKPPLPSRSELSLSSAGDCDGTSAHSPGGKRSKTKSFGLLSRTRSHRDKDRNNNLKAAPVLAPATLGRNENYDNAMPLRTAPVAQDRAFRDMMNSSARNRSEDRAARRDSSRDKEKGALPSSLKENGSGFFGGLRSSSTRAADIISKGLFGKSSRSGSTTEREHAVDDEHYILKVLNLPLVEQTRITRIAKRLETSKDKTEFWMPAFPWRAIDYLNHKGCDVEGLYRVPGSGPQIKKWQRKFDERYDVDLFKDDDLYDINIIGSMLKAWLRELPDELFPKAAQDRIARECSGATKVPQLLVEELSNLSPFNYYLLFAITCHLSLLLSRSDKNKMDFRNLCICFQPCMKIDAFCFKFLVCDWSDCWIGCKNEAKFIEEEYRLFDQPPPRGITVPNGPSHIDEHNDRQLSSTDSNKPSDYDNSNRVLQRQFSGSNASIGSRISTISTNVTTNSEREPQETTRQLRPLSPIKPLSPIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQ75</accession>
    <name>A0A7D5YQ75_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aspartic proteinase yapsin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">YPS3_0</name>
        <name evidence="10" type="ORF">G6M90_00g002850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542798.2">
        <property type="nucleotide sequence ID" value="XM_014687312.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQ75"/>
    <dbReference type="GeneID" id="26244171"/>
    <dbReference type="KEGG" id="mbrn:26244171"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028941386" evidence="8">
        <location>
            <begin position="18"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="70"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="553" mass="59216" checksum="4EA383512B2A8703" modified="2021-02-10" version="1">MHSTLVALIALPFAAWAINSSVNHTVIDDNRAVELPGVLRYPIKGVQGSSGLSKRQDGQSLHSQRHGLIYTIKLDIGTPKSTVDVQFDTGSSQLWVNPICSHAARPADCTKLGRLRYSSTLKTLGKTHKLTYGRGYAYVKYVRDFVQVGSAKLPNQTFGVAIDSGFVSAGILGVGPSKRGMKNSDFVVNSLHKQGFTKSIAFGVDLQGIASARGSVVFGGVDLKKFRGTLHATPILDRAAAPDHAPRYWINLDSISQTAGGETVTLVDQRFPVFLDTGATLSYFPPSIVRKLLQGFPGAKRDKYANYIVNCSLRRQNASVDFQFGSTVIRAAYKDFIYPFDDNACALGFTEATDKAYILGDSFLRSAYVVFDQTNRQLALAQAADCGTRLVAIGPGPAGPLVGECGRPPVTSNTTFHTFTKRTSNKTSSSTKMTTTASPTYTSTLTTTKVYTITTEIVTSLTTSHPGENPKPTYRMHSRLHRGSRLPPHPKSTAGCPNGGDCPPPAVVIPTETGVIPRPGRPLKAPVTAGASSMGAGAFILVITAIVMLYAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQM1</accession>
    <name>A0A7D5YQM1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpb6</name>
        <name evidence="7" type="ORF">G6M90_00g018520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548688.1">
        <property type="nucleotide sequence ID" value="XM_014693202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQM1"/>
    <dbReference type="GeneID" id="26238132"/>
    <dbReference type="KEGG" id="mbrn:26238132"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17090" checksum="76DE8FCEE00CA8B5" modified="2021-02-10" version="1">MSDFGDDDVGVGGDEPMLEEEEVTEYYDPEVLDNEDGERGENGDDADNVVVSGDPSAAANAVKAGEKSLKDKKIPEADRTTTPYMTKYERARILGTRALQISMNAPVLVDLEGETDPLQIAIKELREKKIPLIVRRYMPDGYYEDWTCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR68</accession>
    <name>A0A7D5YR68_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding protein Y14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Y14</name>
        <name evidence="9" type="ORF">G6M90_00g027080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547879.1">
        <property type="nucleotide sequence ID" value="XM_014692393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YR68"/>
    <dbReference type="GeneID" id="26237323"/>
    <dbReference type="KEGG" id="mbrn:26237323"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="37"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI63484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="151" mass="16333" checksum="8C3C04612DBEC122" modified="2021-02-10" version="1">MADVDMDVDRPASPPARNESEMQTHTKATAVRSIEGWIVIVTNVHEEADEEAIQDKFGDFGEIKNLHLNLDRRSGYVKGYALIEYATLEEARAAIDGAHETKLLDQTVSVDFAFVRPPPGKGGRGGRAGGGSGAGGRRQRSRSRSPAAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT20</accession>
    <name>A0A7D5YT20_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endo-beta-1,2-glucanase SGL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g040050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547355.1">
        <property type="nucleotide sequence ID" value="XM_014691869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT20"/>
    <dbReference type="GeneID" id="26239918"/>
    <dbReference type="KEGG" id="mbrn:26239918"/>
    <dbReference type="OrthoDB" id="9981847at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd24165">
        <property type="entry name" value="TfSGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058773">
        <property type="entry name" value="SGL_GH162"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26157">
        <property type="entry name" value="SGL_GH162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028985596" description="Endo-beta-1,2-glucanase SGL domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,2-glucanase SGL" evidence="2">
        <location>
            <begin position="81"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="530" mass="59248" checksum="CE0CDC1D1F40668B" modified="2021-02-10" version="1">MKSLLVAQFLVAGGLTVASALPSLQSPRADQASNPYPRCRFVADWSQEDVLKDPRGFEQDLLFWEGKFHQNNVSYNSANGMTYDGTQLNWTTGARSNKHPFSAASKEALQIMLYAHAVAGSKKAARFLTPDDPSKARKLAASIMKTKLQTYLQFNESNPGFGGFLPWMTTSERQLSPTWDWVNRVPALDNGELVWAVYAYISAAEQRQDQSIRDSARGWQNWLDYVKTTAVTVFYRGGGHVCAVTKMNNQTLPPKHAKQGYQCEGTNYLDDPYEGELFTHFLNAFGGLSREDKDTLWEVKRAKLVSVEYNMGGVGPITVEQGYWFSSHEPWKVLELPYYDVDLVRRLYHNAERARTCNSVVTKVPGLFASVNNSTDPNTDEIIGYISPAGIPSIASQKEQEHDVITPYGVWPTMLFDKAVGLAWWRNMVVAKKMQNLYGSTESTRVDGKLVSALVTWDSKITTVVALLGGVGDLVRSKMKMDRIYKDFIAITKKEYGLVFKDLKGEDIALCLPNETVPDAGLEDFTLCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTB4</accession>
    <name>A0A7D5YTB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenosine kinase</fullName>
            <shortName evidence="12">AK</shortName>
            <ecNumber evidence="4 12">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ado1</name>
        <name evidence="14" type="ORF">G6M90_00g013300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 12"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549191.1">
        <property type="nucleotide sequence ID" value="XM_014693705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTB4"/>
    <dbReference type="GeneID" id="26238635"/>
    <dbReference type="KEGG" id="mbrn:26238635"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1110.10:FF:000001">
        <property type="entry name" value="Adenosine kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="13">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI65304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="336" mass="36343" checksum="91977ABBE7AAB0B4" modified="2021-02-10" version="1">MASAKEYGLLCLENPLLDIQAVGDQALLDKYGLKANDAILAEEKHLPLYEDLLNNYDAKLIAGGAAQNSARGAQYILPPNSVVYLGGAGDDKYSAIMHDAVTAAGLRVEYRVDPEKKTGRCGVVITGHNRSLCTDLGAANHYDLDHLKKPEIWSLVQNAEVYYIGGYHFTVCPPAIMELAKQAAEKNKIFVLSLSAPFIPQFFKDPVDASAPYWDYVIGNETEAAAYAESHNLPSKEPKDVVKHLANLPKENGKRKRVAIITQGTEPTLVAVQGEDQIKEFPVHAIGKEQINDTNGAGDAFAGGLLAGIMQGKDLATSIDMGQWLARLSIQELGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTN4</accession>
    <name>A0A7D5YTN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7025 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g063180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542565.1">
        <property type="nucleotide sequence ID" value="XM_014687079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTN4"/>
    <dbReference type="GeneID" id="26244514"/>
    <dbReference type="KEGG" id="mbrn:26244514"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7025" evidence="2">
        <location>
            <begin position="198"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="443" mass="50571" checksum="8E7CFB9170AA781B" modified="2021-02-10" version="1">MQVKSHSVEFTDIPRDRADTSVREKPVVTFKEDVSFAKDNAASRKDGARSKSEENNGAVPAGKEPEIKNLYTHIYEGKLWWLEQNPDGKLSAIMPPEDVEKFAVIHRRHISEHIESHSIVIHSPHLKEALKPVFQDYPEIDFTSSSLQIMTPFLCFVYRWEQFKAAKDEAARHPETKAYMDLLYNMIVERLRNSVDARKHCLETRTVTFVELWTIYPPGSGVLYRGHDNNPVYGREPGYCRHLQAFQVIRSSYKTATDGKQLYVLECKFISMWQGLAWYQGEVEISQYEGRKQFASLPLIPLEGHEHQGQFTTRLGGRGQKFMNLASSSAQPKEYDRGALSRRECGCRGGGMEVEGRIMLGGEEDGLSPGDYKLLQRLQANRDDVFTSPSSSSESSSSQVPPTVTEDQLMYTSPVIRAWSFKKEAWMDLLVDGMRDVQFDEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTT7</accession>
    <name>A0A7D5YTT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl-38</name>
        <name evidence="5" type="ORF">G6M90_00g063500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542533.1">
        <property type="nucleotide sequence ID" value="XM_014687047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTT7"/>
    <dbReference type="GeneID" id="26244482"/>
    <dbReference type="KEGG" id="mbrn:26244482"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="76" mass="8782" checksum="91747A55E40641F1" modified="2021-02-10" version="1">MPREVADIKKFIEICRRKDASSARIKKNKKSNNIKFKVRCQTHLYTLVLKDTDKAEKLKQSLPPNLSIAEVGKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTW3</accession>
    <name>A0A7D5YTW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g058920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986692.1">
        <property type="nucleotide sequence ID" value="XM_066130671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTW3"/>
    <dbReference type="GeneID" id="26242878"/>
    <dbReference type="KEGG" id="mbrn:26242878"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="549"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="227"/>
        </location>
    </feature>
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        <location>
            <begin position="430"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="686" mass="76448" checksum="1BB108E87C42297C" modified="2021-02-10" version="1">MSISAEADGLRSSYRTVSSPPPVTDSAMLRPNSVNRVSSNSMNILSPSDIVGPSPVTSNGTETTEIEDDALEDVEQTHYGDMSQSSELLMLSTNLPENFRQASGDEAVSVIHAPESFASWTSTESTAQQSQPSDRSFSGREEENSAALSSPMQKPISQPPRPPISTDVKPVRYSIESATPRAQDLQDMLGDGSRLRSSSTSSLEKIDEQTEAEEDDDGNDDYSATPFLRPADDEITALRAALKECWTLCNTLASLSAIHRARVFYSSGTPDAHEKAWKTCWKLCQRLYDNQDEDLASHNVRMNLELCRDFCQALFDVRQKKDETSDSVLRVSFELNNHLYSAQDSRKLPEPFRERTLDFYITLCHRLMKQRSELAEETDHLLSACWTLAEMLFSLRQNKRDGNPVDEELLGSAVQACWDLCDIFRDGWTQIRPDRNTPRPSQTSFFPQQPIEQSGRESRQSNRSSLHSKRESVKSSHQEERPREPPPVPETPVTEFEDTPISPESRSPQMPNIMVLGTPSDTGLGGRWSSNTSNISSYSRGSNRTSSTATTTTATEDPNISRSKLLVLRAAMNIGFNRDAIQDPMSESTVLHKFVQGLPAGSFGSLSSHATLLQQYKSSVLSDKFLPRNHALPVRGKRVIAQDMAKSVLAMSNSSPRYAYLRDLFKFVFQFGVDEAESRRNVSIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUB9</accession>
    <name>A0A7D5YUB9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoprotein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g021450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985716.1">
        <property type="nucleotide sequence ID" value="XM_066129874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUB9"/>
    <dbReference type="GeneID" id="26237846"/>
    <dbReference type="KEGG" id="mbrn:26237846"/>
    <dbReference type="OrthoDB" id="5414836at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38122:SF1">
        <property type="entry name" value="GLYCOPROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="83110" checksum="D147401BF81B303E" modified="2021-02-10" version="1">MEKYHDLQRKNDIYYRNTARRFYRGAIHNQIRYYNSPLDLHKVIDCDPPYTNGYESTEGTNTEQIPKLKGRTHGCRTTTVTSWATTTATKTVTGIESVVTTITVPQETTIHDTHTVVDSTTIWVPTTYTETKTVVSEHPVTLTVDNTKYTTKSTTIVTTFVSTVITSFPVVTTLTLPGQTITAPGQTITAPGQTITAPGETVTAPGRDVTQTLAGPTVTAPGQTSTITLPGVTKTLPASTIVTTQIRTLPPSTVHITDDQETKTITRPGYTVIETSTLTLPPTTIKKPATTVTVTPMFDVSLCPTPTGVSTPLDAKSNRTFGCEPGYVCNPPKPNGCNLWPKPPSDDFLCDPNDCIPSPPFAKVEWQECETGYYPPSYGYFNLDPEGFGLSYDIFEYKVINETINGHPSMITTGNWGSQSSLTAWPKPSPPASHGQMRKRINDHKACHKSKRDIVVPSICYNPCNQAYLIAQGTGKTDGLCDRDSKFRAAEVSCSNCIKANANSNSTSTGEAQKEPFEQFINFCGGTKAEKPPTASPTTPEQLVTQQPTIGTSTQVDVSHPAFTPILSSENIASSAPSTPSPTSSVGSTNSMGSTHSVGSTHSVGSTPASDASSSQTTHSAPPSSGQSSPISTPPGSSTSGSSGVQRPGTSTGGETYSPTTTHRTAVGTTGGSGSSSSRLSNTVVESSLGFPSASASTSASASTSAPASASAPASASASGPSSKIGHGSGTNPGSSESTSNANAGNGGGGQPGATTEGAPGNPPTSTPPVVTAAASHLSSLFYSAGAILVSSVLIMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUE6</accession>
    <name>A0A7D5YUE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g083180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987429.1">
        <property type="nucleotide sequence ID" value="XM_066131218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUE6"/>
    <dbReference type="GeneID" id="90968069"/>
    <dbReference type="KEGG" id="mbrn:90968069"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="203" mass="23451" checksum="1B97DB1EC2691180" modified="2021-02-10" version="1">MSHPTRVDDLYDKQVPRPAKSPAKTAQIQAQNRRREYLKRHPGYFDSLDHELADPVLYERLIKRHQTLSERQQEGQAKGYGRVLEADLARGETRLSALATEAAGEQREDLSPARHRWHAASDIDNPWDGEASTKEQGSELWREFLRERFIRGGDEDFDYAKVDGNEELDVVLRRDEEDRWFDDEEPSWVGDRGAAGETGVQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUI0</accession>
    <name>A0A7D5YUI0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g085240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541081.1">
        <property type="nucleotide sequence ID" value="XM_014685595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUI0"/>
    <dbReference type="GeneID" id="26246070"/>
    <dbReference type="KEGG" id="mbrn:26246070"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="583" mass="63967" checksum="2EB005C31C22F3B7" modified="2021-02-10" version="1">MPYYSSAAISSTEEPWACLMLITIRRITDNQFAESVQRSLEHSMFGSSFCLRATNRSLPDISDSRGSEALGQSRVGSGLTRQSRFGTVAQQRKFRLGHEELAPDPSCPACQSPIDSPPVLHRILNRPGTISISSETLEHPAFSQHNAFSYLPCSSGREPWFFAMPWFEGSRLRAAHRVDVPQRDSAWAAAVQVASNVVGNVVKKAAKDGMTIDPLRTVAKEMQFLTGNIRKLLGSGHPSLDRVAKYYTQAEGKHVRPLIVLLMSRATYLCPKNPQPETVHSARAIDSSISPVTILADVNPSAMPLTSNEPEMKDGNLDILPSQRRLAEITELIHTASLLHDDVIDHSVSRRGSPSANLEFGNKMAVLAGDFLLGRASVALARLRHVEVVELLATVIANLVEGEFMQLKNTERDERSPKYSEETLSYYLQKTYLKTASLISKSCRAAALLGNADATTVDAAYSYGRNLGLAFQLVDDMLDYTRSGKDLGKPAGADLELGLATAPLLFAWKQNPELGALVGRKFEREGDVEKARDLVLKSDGIEQTRALAQDYSEKAIAAIADFPESEAKDGLIEMAQKTIKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVF3</accession>
    <name>A0A7D5YVF3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump dotC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dotC_3</name>
        <name evidence="9" type="ORF">G6M90_00g079490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539921.1">
        <property type="nucleotide sequence ID" value="XM_014684435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVF3"/>
    <dbReference type="GeneID" id="26247259"/>
    <dbReference type="KEGG" id="mbrn:26247259"/>
    <dbReference type="OrthoDB" id="4957408at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="76"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="604" mass="64024" checksum="6C0821EC294B5D60" modified="2021-02-10" version="1">MTAEPAIMTDTAMEARRTCTQNGDAAPNQTGVKTDASNHATAALSRPASLSSPSSPPEPEADAVAKKPSAAGAALLMLPLCLSVLLTALDITIVTPAIPTIVGAFHSVTGYIWIGSAFILASTATTPLWGTVADIWGRKPIMLIAIVVFLCGSLLCALSPTMDALIAGRVVQGIGAAGMGTMVNVIICDMFSMRDRGLYLGITSLVWALGSAVGPILGGLLTTKADWRWCFWINLPIGGVVFGILLVFLNVSNPGTPIVAGLKKIDWIGGALIIGSVLMVLLALDFGDVVFPWSSATVICLLVFGVVVLALFIVNEYKFATEPIIPLHIFSNKSSSAAFGVYSCNFYVFIGLAYYLPLYSQSVLGANALDSGIYLLPLIVASSLSAAFAGIFIQKTGKYLRIMYTGQVLNLLGMGLFIFLPFEKDLAKLFIFQILVGLGVGMNIEPPLIAVQAVNAERDTAAVVATMSFVRSIANAVSIVVGGVIFQNEMTAANPRLVQELGANVAQNFNGDQASAKVNAIWDLPQAQQVIVRKTFFHSLRDVWIMYVAFAGLSLVLNFFVRSHHLSTENQKAVLGADREKKQGNQGTELQTQAANGPTTGSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVF7</accession>
    <name>A0A7D5YVF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MAP21</name>
        <name evidence="13" type="ORF">G6M90_00g077330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545368.1">
        <property type="nucleotide sequence ID" value="XM_014689882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVF7"/>
    <dbReference type="GeneID" id="26241401"/>
    <dbReference type="KEGG" id="mbrn:26241401"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000370">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="131"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI70962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="446" mass="48914" checksum="72CFE3359C821FFC" modified="2021-02-10" version="1">MAAQVPTDALKELKVNEAAKANGKGGKPAPAGDDDDHAEDSDDDAEENAAGNGADGATGAAKKKKKRKPKKKKKNPTAQTEPPSVMVSQLFPNKSYPKGEEVEYKDENRYRTTNEEKRHLDNLNTEFLNDYREAAEIHRQVRQYAQKSIKPGQTLTEIAETIENSVRSLTGHSGLTEGDAMVAGMGFPCGLSLNHCAAHYTPNAGNKMVLQQDDVMKVDFGVHVNGRIVDSAFTVAFESKYDNLLKAVKEATNAGIREAGIDARVGEIGSVIQETMESFEVEIDGTTYPVKSIRNLTGHNILPYSIHGTKAVPIVKSNDQTKMEEGDVFAIETFGSTGNGYVRDDMEVSHYAKNADVQHVDLRLSSAKTLLNVINKNFGTLPFCRRYLDRLGQDKYLLGLNSLVNSGIVEAYPPLCDKKGSYTAQFEHTILIRPTVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVU2</accession>
    <name>A0A7D5YVU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectate lyase superfamily protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g096220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73560.1"/>
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</entry>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="944" mass="99756" checksum="87284F63ABC18FB3" modified="2021-02-10" version="1">MDPTMTEHDFRFPRRPHHPGLRGGADDDDDDGSAAHQTRGLDAAASELTQAVAVANNKLLGGALFPSLDNAGADSSVSIDQLHRDDPLAAQVWKFYTQTKLQLPNQQRLENFTWRWMALNMRKQKQDDEARQFTDQQTGHSRPASHNAPSGIAQLRKTSEINAATGADAMNLDDFIYSENVATPSGLMSPPPAPRRDDASPGATPASGIPIKSRKGSSSNHFVPQSVPQYQRTGNNEFNYVQRHHRKTSIDERRNRKRPANFSPHVLAVNSSISGGASNLEADSEFQGYSLNNTNSVTMQQLTQGGNSAVPFGLDTFMDNDAVMNQAAQFQQNFSFSPSSSPMIPHGPYSNMYNTSSSVPNSSLNNADLYSPTESAYQSTVSTPLALPDNDGLYFGSQDNRQQQQSQNMRQQTVQNMANIGHNQQFMYDSSHNGNQIYSAPDTESGPLSAFSTAPSSYSHIDPNHVFQADSQVASPSVAMRPENMFSFGADSDDEDGGNGMQGQNMQIHGDFSSSMDDVGPMGWDASLPGQFSTQAARFPGGPPRKQVMIGGTTTDYVEHNGEWENSGLERSQSFKAGSDKMQQRLPRTASTPSHMGAKHSGFEQVAQSLPTSPGDAAPGSMSGFSSAAPSRPSSPPGSKHGSSANLQVAGGSQNDGGAPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRGSGPNGSGGSVRSRKNPAGSTAASRKSSTLSMATVSASSTNLNTTANANSSSTSPPGGRSVLPKDSESPVATSVGSGPNTAGSTPNSHYGNMGNTAAAGGKGVVPIAAAPPKATPGPGASSSSRSGQASASSKRQRRHSKSVGTEATSGMEIDSPTETSSPGDLSRSIGHPPSMSSISSTMLSGSFGMVPQRNPMAHGGMIQMNHHQPGAAQHSAGGPATGPQEWEWLTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY38</accession>
    <name>A0A7D5YY38_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g098860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546461.1">
        <property type="nucleotide sequence ID" value="XM_014690975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY38"/>
    <dbReference type="GeneID" id="26240884"/>
    <dbReference type="KEGG" id="mbrn:26240884"/>
    <dbReference type="OrthoDB" id="4941549at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028797263" evidence="2">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="205" mass="21965" checksum="16A800A66807680B" modified="2021-02-10" version="1">MKSFSVILLAVASVSAAPAGTLRRDVGESSTGSVAARAGILDAFTGAVQGVVDTASGVAGDAINLGARAADEPLEDFERKEEEEEEEAARTAAKRAVRLGALQDFEKEEEAEDAAAGFGTRDLEDFEKEEEAEDAAAGISTRDLEDFEKEEEEEEARTNAKRATTANGLEDFEKEEEEEEAREAKASGLDARAEPEEEECVNEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYK3</accession>
    <name>A0A7D5YYK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DPH5</name>
        <name evidence="13" type="ORF">G6M90_00g024780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548103.1">
        <property type="nucleotide sequence ID" value="XM_014692617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYK3"/>
    <dbReference type="GeneID" id="26237547"/>
    <dbReference type="KEGG" id="mbrn:26237547"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="32365" checksum="FBF02A693D17DD5D" modified="2021-02-10" version="1">MLYLVGLGLSDETDITVKGLEVVKKVSRVYLEAYTSILLVDQSVLEEYYGRSITIADREMVESNSDEILRNARNEDVAFLVVGDPFGATTHTDLVIRARELSIPVRTVPNASIMSGIGACGLQLYNFGQTVSMVFFTDSWKPASFYDRIKENRNIGLHTLVLVDIKVKEQSLENMARGRLVYEPPRYMTVGQCAQQMIEIEDEKREGAYTRDSLAIGAARVGGKTEKFIAGTLEELCSTDDLLGPPLHSLVLLGRRTHELELDYVREFAVDKEKWDKIWKEDYGKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYT0</accession>
    <name>A0A7D5YYT0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Styrene-oxide isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">styC</name>
        <name evidence="2" type="ORF">G6M90_00g063840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542501.1">
        <property type="nucleotide sequence ID" value="XM_014687015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYT0"/>
    <dbReference type="GeneID" id="26244450"/>
    <dbReference type="KEGG" id="mbrn:26244450"/>
    <dbReference type="OrthoDB" id="4937695at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058965">
        <property type="entry name" value="SOI/HabA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054803">
        <property type="entry name" value="StyOxIsoStyC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045734">
        <property type="entry name" value="StyOxIsoStyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26512">
        <property type="entry name" value="SOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="190" mass="20292" checksum="2E061F0A94C229C8" modified="2021-02-10" version="1">MINPNPDPTNGLMAQDSLRRRMIGHGALMILTALLGGFGLYMHIMGGIEISPGHLITFNVPGTEAGWVRCHTGSVANGFMVIVTALGMVHLPVPEKAAKRIGWVVVMDGWSNVGFYFFGNLSPNRGLALGKTHVGDADAWSVLAFVPAVVFGFLVVGAFAELGYYGLFDKNNSPGPSHEFDIGAYGQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ60</accession>
    <name>A0A7D5YZ60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fbaA</name>
        <name evidence="14" type="ORF">G6M90_00g110290</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543830.1">
        <property type="nucleotide sequence ID" value="XM_014688344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ60"/>
    <dbReference type="GeneID" id="26243217"/>
    <dbReference type="KEGG" id="mbrn:26243217"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI74322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39318" checksum="404473DB2BB1FED8" modified="2021-02-10" version="1">MGVTDVLSRKSGVIVGDDVLRLFQYAREKQFAVPAINVTSSSTVVASLEAARDAKAPIILQMSQGGAAYFGGKGLSNTDQAASIAGAVAGAQYIRSIAPSYGIPVILHTDHCAKKLLPWLDGMLDADEAHFKAHGEPLFSSHMIDLSEEPVDWNIETTAKYLKRAAPMKQWLEMEIGITGGEEDGVNNEDVDNASLYTQPEDILNIYKTLSPISPYFSIAAGFGNVHGVYKPGNVKLHPELLGKHQAHVKEAIKSKEDKPVYFVFHGGSGSSKKEYLDAISHGVVKVNMDTDMQFAYMSGIRDYMLNKKDYLLTAVGNPDGQDKPNKKFFDPRVWVREGEKTMSARVTEALKDFSCAGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZA9</accession>
    <name>A0A7D5YZA9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trl1</name>
        <name evidence="6" type="ORF">G6M90_00g110140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543844.1">
        <property type="nucleotide sequence ID" value="XM_014688358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZA9"/>
    <dbReference type="GeneID" id="26243231"/>
    <dbReference type="KEGG" id="mbrn:26243231"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051730">
        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001690">
        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012387">
        <property type="entry name" value="Trl1_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019634">
        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="4">
        <location>
            <begin position="396"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="3">
        <location>
            <begin position="556"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="2">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR019634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="787" mass="89083" checksum="6AAC5FCB5D5AFFB2" modified="2021-02-10" version="1">MSSAAPYIPQDIDDVSRMLNALELARKEKRHGGFAIKKTSFQVKGSTNGLKIDSWKLQDWDYKRPDLPTYARGLFTTPKAPRQHPEIAVRGYDKFFNVSEVPETKWENIIVNTLPPYELTLKENGCIIFVSGLDDGTLLVCSKHSTGDRDDIQVSHSSAGERRLERQLSAIGRTKEDLARELRSRNVTAVAELCDDSFEEHVLAYRSDTAGLYLHGINLNLPEFVTYPSPAVQEFADNWGFIKTGFTVMGNVQEVKTFLEDVAQTGSHDGREVEGFVIRCKMSADPATRPYQDWFFKYKFEEPYLMYRQWRECTKALIAGKPPKFKKHHKITEEYLLYARKRLAADPNLGKLYNQNHGIIALRDDFLKFKNINGRDAAFLDDSDPVIMTEVTGDVILCPIATIGCGKTTIALAMSHLFGWGHIQNDNISGKGRPPRFTKAVLDQLEDHSVVFADRNNATKTERKQLITDVKLQHAGAKLVCLNFRHDTESMEKIRSVTQARVLARGDNHQTIRAASEKGKFIGVMDGFIKRFEPCTPYAHPDDGFDVVIELDPVVGSRQNLETAVSRLKQHFPNLIEAIPSTEEYDAAIQNALDYQPDIYHRIPARATDNNTKKKRKLEYMSVDVASDKVNCVIQKAFSASTSQTARFYMQLKQTRRIQSRFHLTLMHRASMDEYPDLWQRYTAAWEAAGGSESQFGECDLLLERIVFDDRIMAVVVRLLDDTGKWECVNRVAHITVGTRDTGVKPKESNDLLAKWIEAGADGEHISEVVLEEKPVLKGTVRGVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZS4</accession>
    <name>A0A7D5YZS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Ank3_1</name>
        <name evidence="5" type="ORF">G6M90_00g065150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986628.1">
        <property type="nucleotide sequence ID" value="XM_066130794.1"/>
    </dbReference>
    <dbReference type="GeneID" id="90967867"/>
    <dbReference type="KEGG" id="mbrn:90967867"/>
    <dbReference type="OrthoDB" id="4938465at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="818"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1231"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1346"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1379"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1451"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1484"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="1603"/>
            <end position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1821" mass="198993" checksum="AD5D2A387D7F8780" modified="2021-02-10" version="1">MALIVLANGVGVGYSTTPWAWNSQEASETAWIAGEFPEADFLSFNWAGDKAHGTADEYFLREALKVIQELQRFNNNGASDCKPTSKSVSQKRIIFVAQDIGVPLVKHVLLLVLKDVHNHWILFQTVALHLIKPPPYYDPKQWRQFGTILGISSQLEQWSTAFANLEVQFSTISGALNQKLYGVAAGHAYLPGDGPCDSQGREPIEEDILCDIRTSLTEASIRLDPGYHTLQRALARPDADICNISLVPSPPGPGAYLESHLSFKAWLKDPGSSVLAVRWYPGSSHKYVASHLMHSLRRMYPGSNTLFLSFSFHRWDARRNSEQCLVSSAVRQLLILKPELFIRARYVAEAYSRGPMVSPQRLWDLFHHLLIILQHTRIFFVVDSVDECGEQIAAKLSSLAASRSISVPLKLVMTSSTPCNGTSNIAFHAISLEDDGWRRVIRDIVAERVSSIARARPVWKESQQLIVEKLCGGQDSIEHDVMLNLELLEQRHIPSTKLALKQFLSTPPTTAYSATVRGLQLAQKRRAKLAINWIFYAVRPLTISELAVALALGTDAEDDVGAAGNLTFSEVAENVSWDLMGDLGDSLSLGVKIVDGHITIPSQTFRSHLETCVDTLIPGFHGYIADRCISYLSLCLTQAREISLCREGDALHPDSICTALALREYAQIYWVDHYNLHMPTIDVLDDKVLRYICLCADHSNETFVSAAYEKTYSPSTGRREDIVSDPLFLAAQIGLARVIRNLVQVDKHKAPEKIERAIEIAASHGNLNVVRELRPGSRPGRLALAACAAAEHGDVEILEYILETTDVSDIDRFTSQPGGTNPLLLSTANGHTSVTEILLARGCNLRSVDESGNTAVHLASRLGDGNTLQALRSARPDDFKSAINTANLEGMYPLQLTCAAGVVDAFALVLGESPEALVQQLYKASRSPIHVAAQHGQLPILQELFGTQAITLRTGSSLPSLIFLAAENGHLSVVRYLVEQLHQRHNTATLEGRKENNTDTKDLERALCTAIINGHVGLVALLATAIDVEYFHLGQAVENSRLEVLKAPIRNSPSASPDNEYDKLLVWAIFRNKVNIVRRLIRHLTRKGVSPPWADDERSIHHAARWGRESCLRAILRRANQDIVRQKDSGSSPLDIAAESSHLEAFKLLLEWEPPGSRRLFRTLRLAIKAPKGHGKVDLVRYLLDNGWSACAVNSDRETPLHIAVRCQGDDLDTIGLLLDRGSDPDASDRCNKSPLYTAAFHGHAKAARLLLAAGANPNQRSIGRTPLHEAIMEGHKEVVGALVGLQGEQDDDATTDTAYEGAGVEFEGLGGSRVNPGAVNSSSVTTGPVLKSMPKTDLEAVLTGTRRTPLIVAAEKGDVEVCTILLTAGANPNAGGGDYGLPLHTALWKGNEKLVKLLMKYKADPNGMSRPFGTPLHVVCGGSEDAKSQRLGLVDLLLGQDAKIDAQDYEGRTPIMIANIYKQESIIDLLLRSGANLDIVDYLGSSALHLAVRVGSDKIIQRLLEAGANADINDKCGRGLLYLAFLCGRSQLLDTVSTALPEDRRAAHISAAMPALFKLDQGIELFDGVFAETGNQGINLNVPDRCGWTSLDLARSYELPGAEIERLQQLGCTEGITKREPTRLSPYDRSDAITVSEGGMCAQVKATEDYPSPLDERILGTVRADYCVPIDKGIFYFKVDVLECGLGNIIAIGLAAESCPMNTMVGWGSSWGYRSDDGVFLSKNHPEGAGQKYGLGQTVGVVYDPTRKRLWFTLDGKKAGEALDHITGQLFPAISLFTSTEPESAGPAEVGVTFPSGLRDAARFRYKTQSLRSISPSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z015</accession>
    <name>A0A7D5Z015_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PKS-NRPS hybrid synthetase psoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NRPS14</name>
        <name evidence="16" type="ORF">G6M90_00g031280</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986317.1">
        <property type="nucleotide sequence ID" value="XM_066130084.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243868"/>
    <dbReference type="KEGG" id="mbrn:26243868"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="8"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="15">
        <location>
            <begin position="968"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="2421"/>
            <end position="2498"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="3570"/>
            <end position="3646"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="11">
        <location>
            <begin position="968"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="11">
        <location>
            <begin position="1123"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2505"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2527"/>
            <end position="2544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="11">
        <location>
            <position position="1000"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="11">
        <location>
            <position position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="4002" mass="438466" checksum="8CB0224BA12BC613" modified="2021-02-10" version="1">MAYTHSPKEPIAIIGSGCRFPGDATSPSKLWDLLRSPRDLTKPIPAESRFNAEGFYHPKGKRHGASNVTKSYFIEEDPRFFDSGFFSIAPREAEAIDPQQRLLLETVYEAMENAGLTLQGLRGSQTSAYVGAMSADYTDTQMRDLENLSQYMITGTSRALLSNRLSYFFDWKGPSISVDTACSSSLAAVHLGVQSLRNGECTTSCVAGSNLILGPDAYLAATSLHLLSPSGRSQMWDKGADGYARGEGVCAFFMKTLSQALRDGDRIDALIRESCINQDGRTKGITLPSAEAQAALIRTTYRNAGLDILRNEDRPQYVEAHGTGTQAGDPREASAISQTFFPPDQELGNKPNIVVGSVKTIIGHTEGCAGIAGLLKVLLAMRHKTIPPNQHLRHLNPSVEPFYKNLGIPTTLLDWPHVPFDHPLRASINGFGSGGTNCHAIMESYVPEIHDHGPWGRPEALRNVQASPLPDVDFTPTPLIFSAASESALVAMLEKYARYLENTDVPIQRLAKTLYSHRSTLGVRVIFPTTSRLELLEEIKKKLSKVRDSPGTEIGTRSSVIEFDENRRPRILGIFTGQGAQWPGMGQTLMKRCALFRTTIENMEQALALLPDPPEWSLKKEIMAPPAESRLGEAEISLPVCAAVQVGLVRLLSQAGISFHSVVGHSGGEIGAAYAAGKISENDAVIIAYYRGVYAKLAIGADGKKGAMIAVGFGYEEGLNFCSNPKMKDRLTIAASNSPKSITLSGNEDAVIEAKEMLDNEGLFNRVLKLDTAYHSSHMYPCAAPYLAALQRCDIKVGKSSATTAWVSSVYEDNRTITDDQDADMKAIYWKDNLIGRVLFSQALECALDDDRGAFDLALEVGPHPALRGPSLETIRSKLGSEIPYAGVLDRKSDDVTALSRALGFVWTHLGSDCVNFDDYSSAFDERNSHIDKTPLANLPTYPWDHKSILWRESRLNRQVRHRSDRPHELLGNRTPDDTEYEPRWRNFFKLEEMPWLRDHCIQNQIIVPAATYCVMALEAARFLGRGKHVVNIELSNIAILRPIVLDESSGGTETLLSLRSDLDSNKGKSDVIHAEFSLSAGTVEDGHLRTAASGEIRVFLANDGADYSTFFPLRSEKTQSELLPVNVNRFYESLSQMGLGYTGPFRAMTSMRRQMDTASSVVEIDEDVGRSIPVHPTWLDVCFQTFLAAFAAPRDASLWTAFMPTTIGRMAFSPATRATPNGPASMTVDAQLTELTPAFQAKLPTITGDMSIYNSKTGRLEVHIEDFTMSSFLPATEKDDRRLYLKTVWRPDILSRATFEAQQQIDSLHELKVIDACEKVVRFYLSKLRREKSFPEIVKTIPGLLGVVEAATASTVSEPTEPELASILQEFGHHIDMTLVTTIGEQLLQNSGLSPVPAEAPSSLGDLVSRWHHEGLGFTQVHQHIGSAAKQISHRYTNLRVLQVGPSSASLVRALCQGLEHALDSYTIVDGSEHIVEEIRAGLVSNKLRVDAKVLDVEAGLGEGNDAFAAGSFDLIITHKAFRKQAAALRTVRDLLRPGGFLVMMAATGPQLRFPFFMLSAPAPVNDDQGSIQPQLLNSTRDEIHSILQKSGFSGVDSMALDNVEAKHTFSVVVSQAIDDDVNFLRTPLAWTSPITTSGKILVLGGSSLKVTNIIRIVQSHLSRVWSGEIVTVESLSGLLSQEVEEAEAVLSITELDQPILERLNAPNFQNLQMLLDKSKALLWITQGASESPYQSATIGLGRSFMSENPQKALQFLDLDTVTGNEAVLAESLLRLIASAVKTTDASKGGSRLWMIEPELSLDKGTLLIPRLVPDKKRNDRLNSLKRKVETQALVGTRAVTLVPSLHNAGQVAYTAEETLNHRSEPASDQVSLRVEYCSADPVLPNHHGDNLFCCVGRTQDEERFLALSASNSSAITVPRAWTIRLSDDKLKESAILSVLFHALHRIKARVIEASMPLGYITLLYETDAHLASSIDGPENLSGKEYALISYKGHSNGDCPRNGIYIEPHMSRKAMASLIPSKSRLLIHPGHRSDRRQLQAIQQALPKNTAVVAFQDLDSDRLITHDVLLGALDSLPPSPTATFDSTQVVKASSLVMDGINSHSSVVVVDWTGDQVITLTQRPVNPQHLLSPNKTYLLVGLSGQIGQSMCRWLVTNGARHVVVTSRNPDKEGLWKDELQRQGANIAIEAANVTNKQELVDLRTRILSTMPPIGGVANGAMVLSDKLFADMSYDSFQKVLSPKVEGSKNLDEIFSGDDLDFFILFSSISAVTGQRSQANYAAANNFMVGLASQRRARQLPASVIDIGMVIGIGVIQRTEDDEGISAMETALRKLDYMPVSERDLHHLLAEAILVGKSDECPEIVTGLETFNTASGNQPFWHRNPRFSHLKTDVGSTQAGQGSTNSVQRTLKEKLADARGPNDALQTMEEALVAYLGSSLKLSLESIFTDVPLIDLGIDSLVAVEIRNWIFSEAGHDVPVLKILGGSSIKQICTDVVSSLSFEAQPAKAPESQAQAVPLPSSRDWNKPSTETNSSDDTSSSSKSSDLTPQPGSYAASRLSSASPDITLDAVEGKSSRPIPFRTESLSLGQSRLYFLSQYLDDNITLNCTASYALSGKLDVSKFEKSILAVIQSHEMLRTTFYLDEQDAKPVQGIIEKSPFKMTIISGNSDMEYVKSELDRTRNYQYNLEMGDTFIATLLSHSADSHTVIFGYHHIIMDGVSWQIFQQDLAKFYNHPSLISSPKSLPAQYVDFTVKQQRDIAGGAYAHRLKFFQDCFREPVSPLPLFPFAKVSTRRSLTRHAVRDVALHINPETLNAVKKASQASRATSFHFFLSAFQVLLHRLLSTEQMCIGVVDANRSEQAFSGTIGFFLETIPVLFQVDGDQRFSNVLQTTRSKAYAALAQTGVPTEEILRACNIPASTTETPLFQVVFNYRMGASRTSQMQGLDMKFSHYTDAKSPFDVVVSVDELNDGTAMVTFSLQDYLYDEEGAELLAKTYKHLLEALANDPHRPVGSIPVFDTTLIEQAVALGTGPKIELAPSSAGTLSKMINTWTSKDPNSLAVKDVNGNTKTYFQLSERANGISAELISDETVSLSPICVLLEPGTDTIATILGILRAGAAYVPLDVRSTNERLSDILEESGSTILLHHRATEQRAGELQRLSKNSQRIRLFSIDSIPQNTTERVEDLSTTDGLAMILYTSGSTGKPKGIPLTNDNIRTTILGVSKRVPLGREVVLQQSGQGFDAAIFQIFIALANGGTVIMGDNRAEPAELAALMAREGVTCSVFIVSEMQSMLKYGYDELRTCSSWRIAMVAGEVFTINLLDQFRNLNRPDLRIINAYGPTEASICSSMHEVLPSDIRTDYSSIPIGKPIANYGTYIVDEECRPVPIGWPGEIAISGPGVADGYLHLPQLTERKFKRRAFHKQTSGYDRLYLTGDKGRMLCDGSIVMSGRVDGDDQVKIRGMRVQLDDVSRVLVQASGGNLVDAAVLLQGNDATTQRLIAYVVFSGTSHIDDKPTYLHKLNQELPIPPYMRPVMTIPLDILPVTERGKLDSRKLAALPLPEVSPNTCHQMTEYEARLRDVWTTVLGDISLSVPIQRDSDFFSVGGNSLLLLRLKSEIRRVFAVDIPLSDLFQYSTLELFAARLTGNSQLDHINWDRETEPDDAICQSTPSAKTPRAPSHKTEGISVLLTGSTGFLGTAILRQLVTLPQVVRVHCAAIRDDGRDKPRQLGVDSPKIVRYSGDLALPHLGLSPEQMAQICNDIDVIIHNGAEVSHMKNYRSLRAANFLSTIELAHMAVRLNIPMHYVSTGGVARLSGAAVQTESSLAAFYPPSDGSDGYVASKWASEVFLEKLHSRMQGQTWIHRPSSITGNDMPTLDIVHNLLRFSASMKAVPDLAGSTGSFDFIHVDTVSKNIANCAVSSTGGDGREPPNHLTFVHQSGEEIVPVNQLKEHMEAAEASPFRVLPLREWVVGAMEEGLDEVVGSFLLGSGDRIRVPLLQRGDCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0E4</accession>
    <name>A0A7D5Z0E4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g080650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539339.1">
        <property type="nucleotide sequence ID" value="XM_014683853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0E4"/>
    <dbReference type="GeneID" id="26247882"/>
    <dbReference type="KEGG" id="mbrn:26247882"/>
    <dbReference type="OrthoDB" id="5070004at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="15359" checksum="737E523DA68DAAB9" modified="2021-02-10" version="1">MVSKTTTTKIRNAGHLNYRQIGTIWPRHSYSYNKELFGVMFSHYSLYNSPHLALMALTQDMIQDLDSSMTKDRERVFTTRRCRESISRAWESDRRHVEAIEDYRRGIDYGGQGLHGQLICDGDGDEAPPGDTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Q3</accession>
    <name>A0A7D5Z1Q3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g055350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540875.1">
        <property type="nucleotide sequence ID" value="XM_014685389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Q3"/>
    <dbReference type="GeneID" id="26246181"/>
    <dbReference type="KEGG" id="mbrn:26246181"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="138" mass="15358" checksum="21831CCC71174751" modified="2021-02-10" version="1">MAIRFDRKKRSGIEHRFANPLPTEEALNQTKLRAEESVEARMVMTSLQHLALSLEDTHETIQRVGYIGAIKKAGAPPFSGSVSLLESNGHKSLTDESHPPFGMAVQTTDILNVLPYKHPEDLDSFNDSMALRRTSDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Y9</accession>
    <name>A0A7D5Z1Y9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase FUM15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g059870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544556.1">
        <property type="nucleotide sequence ID" value="XM_014689070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Y9"/>
    <dbReference type="GeneID" id="26242968"/>
    <dbReference type="KEGG" id="mbrn:26242968"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61629" checksum="DA59088D1974BE9A" modified="2021-02-10" version="1">MAVPLPLFTAVAAAGTLLFITQQQEWTRKLAIGAFAVVFGIQMVIYSIYSLFIYPFFLSPYRHLPKPPGGDYLFGHTRQMVKEGLGTTARKWIASIPNDGFIHIRWAFNREMLLVTSPQALSEILVAKSYEFAKPQFLRDTLGPVIGHALVLAEGDAHKLQRRNLMPAFAFRHIKDLYPLFWQKSREVVRVMTAECDGLGVLNMEAGAWASRCTLDVIGTAGLGRDFDAIHDDHNELVETYMTLSHPSKTDRILMILADFAGLFVPVKPFLNVPFPRLRQVQRSSNMIRDVCRDVIQAKKQKLEKGQLNDVDIVSIALRSGVFSEDELVDQMMTFLGAGHETTGSALTWAIYALCRFPDIQSRLRDEIRANLPSVDEETDITSADIDKLPYLNAVCNEVLRMYSPVPQTFRDAVCDTSVLDRRIHKGTRLILAAWGTNVDTALWGADAGEFNPERWLSVNDGGEHSVKRASLGGASSNYALLTFLHGPRSCIGQAFAKSEFACLLAAWVGRFRFELKDSRLMDEENMVFEQLVTVKAVEGLYVKATVVPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z222</accession>
    <name>A0A7D5Z222_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Centromere protein V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Cenpv</name>
        <name evidence="5" type="ORF">G6M90_00g043640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986306.1">
        <property type="nucleotide sequence ID" value="XM_066130330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z222"/>
    <dbReference type="GeneID" id="26240261"/>
    <dbReference type="KEGG" id="mbrn:26240261"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="153"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="298" mass="33860" checksum="211961E55E9AF763" modified="2021-02-10" version="1">MASEDNTRQPLRTYRGNCHCKAFVYEVQLPEIKAVKQCNCSICHKKGYLWVLAQETGHFKIVKGGEDTLSSYTFNTKNRIHKFCPTCASPVMAVAKQAPPNRTIGINVHTLQNVDTWALQKERIDWAKVEPMYIVPEHKGAEPSANIEGGKLYKGGCHCGAVTVAVMSKPLDETFEDGGLECNCSICERNGYVWMYPLDEQVVLHAEEPANIGRYAFSMHMFNKTFCKICGVNLTNEYNADQNEEQKARRPEQAEKWEAWARRHHPVNLRVLPEVDISKMSRRYGKGYTGIPLLYENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Q1</accession>
    <name>A0A7D5Z2Q1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine aspartase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g072250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545838.1">
        <property type="nucleotide sequence ID" value="XM_014690352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Q1"/>
    <dbReference type="GeneID" id="26241871"/>
    <dbReference type="KEGG" id="mbrn:26241871"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="401"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="62272" checksum="A3AC1D95E532E5BE" modified="2021-02-10" version="1">MAQNNHGTDGALDRMLRLSQRQKAVPAIFIHAGAGFHSHQNEHVHLEACVAASEMGMKFLKAGATATEAVEAALRILEDKEITNAGYGSNLSIDGTVECDATIVDHLGRSGACGAVPNIRNPISLAKLILDTSSQPLSLRRVPPNALVGEGARIFAEEHGVVTFANEYLVSKNSRDRFFRWQEDLLRAEERVQDSRTGLQSPSVTMACVPCQYDTAPSADTRKPFPREHTAAILAGTWNEGQPDSPYAGTPAPDSASMQEGSFFSPRSNVSPSAPTSKSPRPSPRSPISSASLAESKIIGVSPTRARYIDRRPDVVVDSPSPTGTIRRNAPEISRSNNSFTLEASSPCIQSNQCDNTPSIPSGLQGVKRPFHEENQPRETDGPVAKRQVRLNSRDEDMITDTIGAIAIDDQGRIAAGSSSGGIGMKHRGRLGPAALVGIGTAVVPCAEDDEEGITVAAVTSGTGEHMATTMASQRCAERIYTGTRRAPGGGDMQDDDEDAIMESFISEDFMGHPGVKNCNSQGAIGVMVVKKSRTGYYLYFAHNTDSFALASMGALEKEPRCTMSRLPDGAKIAKGGRKIRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2U5</accession>
    <name>A0A7D5Z2U5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g089890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541648.1">
        <property type="nucleotide sequence ID" value="XM_014686162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2U5"/>
    <dbReference type="GeneID" id="26245511"/>
    <dbReference type="KEGG" id="mbrn:26245511"/>
    <dbReference type="OrthoDB" id="4937259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="442" mass="46340" checksum="37531E6DF393B143" modified="2021-02-10" version="1">MAFSDDMPQQAMALFNASWADNYTDMQQLLASGANYTFAKYDGVTALHVAAAAGSRAAAQLLIDAGANISAVNVDFETPLHVAAHFGHDEVSQKLVAAGADILARNCYGETPLQVAASRGYQDVVRLLIHEAKNRMKLSEILSTKNNNGDTALHSAISGGYAMAKMLLDAGADVHSRGEGEDTVLFRAAEASEDMVELILAAGGDVLARTDDGTTVLHRAAAWGSASILQQLIAVGVDVSLATNDGQTPLHCAAERGTEEKIRVLLDAGADISAQTINARETALHLASAAFPDMRAKVLLDRGADPNTPKLGGETPLHLAVAAAKGGGDVSVVAYLLEAGANSNAATDAGETPLHVAVMNGSPTSTRLLLNAGADPSAKAHDGKTPLMLAQEKRTEAKAYCIEVSKEPWAEPGMCDEYLSRMEEVVMLVEETQDAGLQELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2Y3</accession>
    <name>A0A7D5Z2Y3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UGD4</name>
        <name evidence="11" type="ORF">G6M90_00g074150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545651.1">
        <property type="nucleotide sequence ID" value="XM_014690165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2Y3"/>
    <dbReference type="GeneID" id="26241684"/>
    <dbReference type="KEGG" id="mbrn:26241684"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="389"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="322"/>
            <end position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="626" mass="68214" checksum="4220FC8D76F9B0C1" modified="2021-02-10" version="1">MHEAVVDSVKKLGLNGSSEHTNGVIKDGFKVRTICCVGAGYVGGPTAAVIAFQNPHIKVTVVDRDELRIRRWNSRHPPIYEPGLHDIVRVARDGSRDFTFANESASESELTSAQEGDISVPSRPTNLFFTTDVAKSIGEADMVLVAVNTPTKDRGVGAGSATDMTAFEAVTAVVAQYAREGAIIVEKSTVPCRTAQLVADTLSMHRPGVHFEILSNPEFLAAGTAVNDLLYPDRILIGSAPTPSGKKAAEALVEVYAAWVPRDRILTTNVWSSELAKLVANSMLAQRISSINSISAVCEQTGADVDEVARAVGVDPRIGNKFLMAGIGFGGSCFKKDVLNLVYLADTMGLPEVGEYWRQVVKMNDYARDRFTNRVIKCLNNTLVGKKVAILGYAFKKNTSDTREAPALEMIKTLLEERPREIAVFDPCCNPLVIKEEIKTLLGDVAAGNNISVYGNAYDACSGATAVVIATEFDEFRNQPAPKPSPTPVVQEAAPKMIGRKPNPKSDPRPFERPVPTENDLLALHKYLVQRPSETSDDPLGRFNIEPSCADDCPDCIQERQSKKTGHATGMGSAEEYKAKERIDWVRIADAMAKPRWVFDGRGVIDSREMVKLGVRVESVGRQHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z320</accession>
    <name>A0A7D5Z320_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g004610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542110.1">
        <property type="nucleotide sequence ID" value="XM_014686624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z320"/>
    <dbReference type="GeneID" id="26245141"/>
    <dbReference type="KEGG" id="mbrn:26245141"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000013">
        <property type="entry name" value="Similar to TBC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000034">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="442"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="713" mass="78806" checksum="E8C41A7FE046940E" modified="2021-02-10" version="1">MIHEQVVSNIIPSPGSPPGMTTSKSSKSSSFQSLNSDDGSVLADVSHFEDIGLDDDNVTLKVNVRPGPTPLVTPVARNLAGGKRPPGPKPRRSFPNLHTSVYASNPRSTSLAGLTDPRPLSLNRGHSTVSLPVARRNRSTSPNLSLNPRDINLPPKPQPRPRRGSWQATRRKSLQDLEHECDEDDGDDIPDGIVLDNVPISPRPANERPPSRAPSISPSPDRAPKERVRSIGNGTPAVAQAQGSLRSPSWRSDASDKPPPSPVKSRANSWNLALADLNAESKALTEKLEEHADELHERSSRRPSGAARPNTWNSSHMPYDHVYDKKARVKSSTPELPPLRRTDIMIDPLPISKEKEAVLSRTRPSWLPPKDPAEERRHLKEYQKMMAASAKADERREAARRSRTESRDNTADNLMHIWEGDIIPRWNDAIRERRTRDMWWRGVAPRSRGVVWARAIGNELGLTEATFRTALARARDLEDRVRTDRADAEDARRAKWFEQIRKDASDKTWKNLKIFEITGPLHSSLVDVLSAYAMYRSDIGYVFGCNTIAALLLLNLPNAETVFIALANLLNRPLPLSFYTADETAQASAYNLVLQTLGHKSLPLRDHLTKTMRDVTPELYLGGMFLSLFTGHLAIDEAARLWDVYVFEGDALLVRAAVALLLSREMALLGSKTSDEVLAVITRANSSTGAARAVAAVGAEDRFMAAVREAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3S8</accession>
    <name>A0A7D5Z3S8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Efflux pump FUB11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FUB11</name>
        <name evidence="7" type="ORF">G6M90_00g095380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546792.1">
        <property type="nucleotide sequence ID" value="XM_014691306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3S8"/>
    <dbReference type="GeneID" id="26241215"/>
    <dbReference type="KEGG" id="mbrn:26241215"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="84"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="586" mass="64107" checksum="9F9CC4170A692D5B" modified="2021-02-10" version="1">MVSARELDNTTEAGGCCSFGFAREHSSITGLGEKSPITYCYLSFDTALPSVPKPQQSVSVYPPCPDLKPYMSPLKWSPARKNVSLALSCVATFLTAYTAGCYSPPAGIIAQDLGTTRIVTLVGITTFCAGFAFAPMALAPISEIWGRFPVFIVAGVVFVVFQAICAVMTHIAGLLVARFFVGAGASVFSSVVGGVIADLWDKKERNTPMALFSGSVLAGTGAGPLVGTAFMKRFGQTTTAWKWTFWHQVVLDGVLLILLILLFKESRASVLLTRKAKRLNQWYEKLESRGIYGVCMPASSPPLPIASGASSDEDQKGGHGSQDRYLRIRWVVREDEQRPPVFQMMSLSVRRPFHMLFTEPVVFSFSLWAAFSWAVLYMSFSVVPFLYENSFDLSSRVYGAIMAAAVVATAVSILQQHLLKHPQWRVHKGDFEYSDSRFWAFMRNRFPTDSPEARLYFACVTALFLPAGLFGAFLCPESMSGYAEAVGLGFAVWGIYSIYLATFNYLADSYQSYASSALAAQNFCRNVLGGIFPLIVKAMFTNLGLKGAGGMLGGIAMVLSVIPWVLLLFGQRIRSRSKLANSLQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5W4</accession>
    <name>A0A7D5Z5W4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Karyogamy protein KAR9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g101160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546229.1">
        <property type="nucleotide sequence ID" value="XM_014690743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5W4"/>
    <dbReference type="GeneID" id="26240652"/>
    <dbReference type="KEGG" id="mbrn:26240652"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="852"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="900"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="116077" checksum="0E6E52933F3666B2" modified="2021-02-10" version="1">MTSDRPGSGVIAHSVHVPGSGIDDEEIAVALQSQKLENQPRDRVKEQDENEVFQVLSFADVPANISDLPAPRGPFPASTIGTTTTIGATSEDEPSTIPIPLETPALSRSTTNNTIRSTSSGSFTSSTTNNPNNPNSAHACAPGPAQPHHHPPTSAIRKTSPGLAARLKALGFGTLKQTPSVPTPHHDHIGRLDEQQLRQLDENHQANSISSIIARRGRPWKGAGASTSALLNSTTEPIVTAESPQLPEIKTPEPLAMDTQKYRLPDHTNGNGTKVTLDTRREHIERTTLPSSPPEALPPPPPPKDTPPPVTPPAIASSNEYVAGLDSYFTPGHNRPVSIYTLSRASFANQLAQLTSLQLPDAETLSSKVSSIRTAHVATKALINASEQIRSWISKAQEVIGGLDSEDDVEWAAAGGREGLEEVENAITRFEDLINAYIGAIEELQKRNDISHVPSEDLNKAVAQMELIVDEWAHIRATLQSVRVQVEIAMEWEELWNNVLGDIQGEMDELSRLVFEMEERRHKSVVAAAGGDTVDIGDLENIVEDTPPPVTRLQAPSRFGLPSVPMSPGSPGTPSLSQDDSSLLALFARMQPLRASLDFLPMRLSVFEARAEKAFPTACEELEMRRTGLDGSYKKLEKDAESLRKELGEDRWVIVFRGAGRQAQKMHESVQRSLLKLGEAIDTEVHLQSPPTMMKKIESYEAKKTHYGPAIERVLSIIDKGVKDRLTVNGEILRLHADMQTRWESLKAQMQEMDAIIDDIQADRKSQQLRDSVSSMLSYDRSTVGSGRDTPGSSPPSSAIMNSLGFDPQTPLTRGKGRSPALNKISQSTGRRHSSLPAPSSTLNRKTGPRLSTIASSSAATPATNSRTPGRPGATAGYRPPWNGSTNTSDIDTGHHFQPLSLTIPSPYTKSSPSNQRSVSAATPSSASRLPTLRGAFSRSASESPQVDNTPSRGGHSRLSFRERLTSPGPYSQQTLSRPRLTSQSSMSTLNSNRRISMQPTGSESAVEESQLSRPASSLASSHRRTSFLPHLRRESSTGRNSPQLFTASRTSTKKGIAEPKDSKPRWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z652</accession>
    <name>A0A7D5Z652_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g060440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544614.1">
        <property type="nucleotide sequence ID" value="XM_014689128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z652"/>
    <dbReference type="GeneID" id="26243026"/>
    <dbReference type="KEGG" id="mbrn:26243026"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12488" checksum="D9EAC0D16B329EA0" modified="2021-02-10" version="1">MSGHSNVGTSAVYEAGDQRNVKASERNTAERFEEGKPGSHSLTDSKDERTISNRLAAEEKRRKQGESDDFETAMSKKDPTLPAKMHGNEPSQGAKIDAELAAEDAQRIKEKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6S5</accession>
    <name>A0A7D5Z6S5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase apdG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apdG_3</name>
        <name evidence="10" type="ORF">G6M90_00g107150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544123.1">
        <property type="nucleotide sequence ID" value="XM_014688637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6S5"/>
    <dbReference type="GeneID" id="26243510"/>
    <dbReference type="KEGG" id="mbrn:26243510"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF15">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE APDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="159"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="267"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="441" mass="47852" checksum="51540F3D33F8C035" modified="2021-02-10" version="1">MADNLENPVPFSEPPYLCGLPSPYYTESHRQFQKACRRFLWDNLLSNAAEWEKEGTVPEHVFATFCKSGMLLPNMPAPLPVEWLKDLGIHDILGVKVEEWDYLHTGIYCDELARSGLAGPGASLTAGFAFGIPPIVKWGSKELKQRFLPDFLTGRKRTCIAITEPDAGSDVANITTTAEKTADGKHYIINGAKKWITNGIWSDYTTMAVRTGGPGRAGLSVIIVPLKGYPGVTMRRLPVGGQKAGGTTYIELDNVKVPVENLLGREGDGLRIILTNFNHERLIIAVGVTRQARTALAAAFEYCLKRDAFGKKLMDQPVVRHRLAKAGAELETMNAWTEQLLYQLCHLSSQEADLKLGGITALAKAKSAMVLNECAQVAVLLFGGNGFTASGQGALVEAIYRDVPGARIPGGSEDVLLDLAVRQLVKIYQFGGAAALKGAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6W3</accession>
    <name>A0A7D5Z6W3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g064380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540105.2">
        <property type="nucleotide sequence ID" value="XM_014684619.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6W3"/>
    <dbReference type="GeneID" id="26247141"/>
    <dbReference type="KEGG" id="mbrn:26247141"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="181" mass="19418" checksum="420C56F5CF1839DE" modified="2021-02-10" version="1">MATISGIIIIINNNNKFQEDLGDLDPVTGAWVISAGGQTILHDRTAPAPPLFTGSISCGLCMLLFAIVGAVKPNSIAGANILAACARVYLFAYGATIASTIWLYFELPETKDRTLEGIDDMFLNANCTGPVYISRRWLPLIQCHYYFVLCALAQVFPSKVFPPENSNATSAPAKSGMVING</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z792</accession>
    <name>A0A7D5Z792_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SWC4</name>
        <name evidence="10" type="ORF">G6M90_00g075340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545563.1">
        <property type="nucleotide sequence ID" value="XM_014690077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z792"/>
    <dbReference type="GeneID" id="26241596"/>
    <dbReference type="KEGG" id="mbrn:26241596"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="656" mass="72725" checksum="EC55DC0A41ED8544" modified="2021-02-10" version="1">MTSSDVRDVLNLGDSSSGPRPSKKQKIGQPKPNLKGLAREVLNLGGDNPVSIIPAKNQFKKRRLGGRKPAARWELREFRNSGRDDRSLILRHWRRVDTKDLAASSGERQQQLEAQLQDGGQEKNGEKKESEAERDIEDSAFAKFNVRIQVPQYSQDQYQVSLQNEDWTKEETDYLMEMASDFDLRWPLIWDRYEYQPPATNGATDVDGDESKAIVPATRPRSMEDLKARYYEVAAKMMAAQKPVQYMTQQEYALHETMAHFNPKQEKLRKEFAMNSMSRSKEEAREEESLLLEIKRIMARSERFNEERRELYNRLDYPRAETDINPFKSSAGLQTLLQNLMSTDKSKKRKSIMGTDSPAGPGPGAAGAAQNAAAPESGKRESAAVSNAATRESTAATSTPTAASKKAQQQEKQQQQAPERRKLNSQEEAVYGVTHHDRLGSGPTFRTEKINKLFSHKSNQQQLRINNTLNELDVPAKLAMPTAATTLQYEQLLAAVNSLLDARKVSDKLDGEIKIEQAKKAEREKNQGPAAPEKETAPADSERKTDGEVKKPDNATTSGDQPESADKAAGPAGEDKDKADDVKDQQVPPAGTGDGAEESTSKSEQDQEAAAATEKVTAVEPEREKSARPGSSSGAHKRSASVLSSVSDKSAKRQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7A9</accession>
    <name>A0A7D5Z7A9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g043010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986601.1">
        <property type="nucleotide sequence ID" value="XM_066130315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7A9"/>
    <dbReference type="GeneID" id="26240198"/>
    <dbReference type="KEGG" id="mbrn:26240198"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="123"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="242" mass="26342" checksum="79694EA9116F0D0C" modified="2021-02-10" version="1">MAGGSAAGSRGRAGKFNKPTRGGGKHYSRSLQPVDADGNQVSMWSAGAADERSEEDSEEESSEEESDDAGPSKATADAENRDDRKALKKARKEAAIAKQKSREVQVGDMPSSDDESEDGMPANPNHSRSARKQANSSDVDDITEGVQNMNVPGNRKEREAAEAAAAKERYMKLQAEGKTDQAKADLARLKLIREQRAADASRRQAEKEEREEQEKTRKAEIEAKESKKREAAAGPKKASKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7E0</accession>
    <name>A0A7D5Z7E0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scytalone dehydratase-like protein Arp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Arp1_5</name>
        <name evidence="10" type="ORF">G6M90_00g078980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Scytalone dehydratase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer. Each subunit contains an active site, located in the central part of the hydrophobic core of the monomer, which functions independently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the scytalone dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987174.1">
        <property type="nucleotide sequence ID" value="XM_066131098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7E0"/>
    <dbReference type="GeneID" id="90967997"/>
    <dbReference type="KEGG" id="mbrn:90967997"/>
    <dbReference type="OrthoDB" id="5281072at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030411">
        <property type="term" value="F:scytalone dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006582">
        <property type="term" value="P:melanin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004235">
        <property type="entry name" value="Scytalone_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049884">
        <property type="entry name" value="Scytalone_dh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02982">
        <property type="entry name" value="Scytalone_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024851">
        <property type="entry name" value="SCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR024851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR024851-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="183" mass="20817" checksum="E4199B08176F2915" modified="2021-02-10" version="1">MNQSLTPSAGTDSKTGSSKAISLQDYLDLSTLVFEWADSYDAKDWARLRAILAPALYVDYTKIGKEKWDAMSADDFMAMVSNDDFLGDPCVKTQHLIGATYWERVSESKVIGHHQLRAAHQVYTSPDLKTVKLRGHSHATNEHYYVKSNGVWKFAGLKPEVRWNEYKFEEVFKGSYTQSEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7S2</accession>
    <name>A0A7D5Z7S2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="5 14">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SOD1</name>
        <name evidence="17" type="ORF">G6M90_00g060540</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="5 14"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544623.1">
        <property type="nucleotide sequence ID" value="XM_014689137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7S2"/>
    <dbReference type="GeneID" id="26243035"/>
    <dbReference type="KEGG" id="mbrn:26243035"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="12 14" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="16">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI68789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="154" mass="15658" checksum="E213E56921ED01F5" modified="2021-02-10" version="1">MVKAVAVLRGDAKVGGTVTFEQESESAPTSITWDITGNDPNAKRGFHIHTFGDNTNGCTSAGPHFNPHGKTHGAPADEARHVGDLGNVNTDAQGNAKGSVTDSQVKLIGPHSVIGRTVVVHAGTDDLGKGGNEESLKTGNAGPRPACGVIGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Y1</accession>
    <name>A0A7D5Z7Y1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g111910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987858.1">
        <property type="nucleotide sequence ID" value="XM_066131841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Y1"/>
    <dbReference type="GeneID" id="90968265"/>
    <dbReference type="KEGG" id="mbrn:90968265"/>
    <dbReference type="OrthoDB" id="4777529at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase (KR)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="116" mass="12770" checksum="657BE494511FC385" modified="2021-02-10" version="1">MDPNATFVIAGGLGGIGHVTKPVDELQSKGVRVETPACDIRDLERTRETFGKLMPEMPSTKGALQMSIVDCLFDDLEYDDWSIAVRCKTVRLWSARGRCNGTGWTPFWSLSFGIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8L7</accession>
    <name>A0A7D5Z8L7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein AIR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AIR2</name>
        <name evidence="3" type="ORF">G6M90_00g074330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545633.1">
        <property type="nucleotide sequence ID" value="XM_014690147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8L7"/>
    <dbReference type="GeneID" id="26241666"/>
    <dbReference type="KEGG" id="mbrn:26241666"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="689" mass="73857" checksum="5104F07DD46F8826" modified="2021-02-10" version="1">MSAKNGNETPGDVIRLGDSDDESNYEPEIDQEPISQPAPQGMDSQLSTAGQKRPRNEADEGEAHGFPPAATVHEHVPSRHPKRAKLSTSPSNHTHQASEECEVDESESEANPRAALEKGKEYMLVSAAEATAPPAHSTAATSPPATNGLSTSGHTTDQAEVDDLEPVTRAHMPREPPTYTVGSLSLDLPALSRKKQGSWTARFKDWAQVLCKHNPHNASAITPTVATDAFIYYLDTHNSRLRQAKKKAAKQAAKSLLLAGTTKTAIGETKSSTDASPHQPAAKPPAKTQGANDGSPEEGEVSSNGGRPAPTEMKYKTQNGDVSIVREGVPTGPEELEQQRRYFPSAADPSSMCLLCGLEGHRAIHCSRSKCRFCDSYDHWDFCCPSIQERCAKCRQLGHKAAACVEKLAMTTDEGLACLYCKSSEHLEDSCTDIWRSFHPEEQTIHKVVYLPSSCAVCGGKDHLSGDCRHRRGVCSNPTWSLQNRSLYMDYSCDALSIEDAANPEGNRKPLRAPETKIRGHAARTANIHYSESDDSDIEFLGKKLPKAPKEGVGKSRKSSYIQLTLPQMMGSHAVNSFQPLADQPPLPPGPPPSGPLTGGQSSRHPPPPGARGYHSQPTAPPPSLPSKPPPSTRGYHSVPPPPLLPPTNANRSRGGHGDQGGRGGGGGGAGRGGRGRGRPRGRPRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z966</accession>
    <name>A0A7D5Z966_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-1,2-mannosyltransferase MNN22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MNN22</name>
        <name evidence="11" type="ORF">G6M90_00g082310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543460.2">
        <property type="nucleotide sequence ID" value="XM_014687974.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z966"/>
    <dbReference type="GeneID" id="26243637"/>
    <dbReference type="KEGG" id="mbrn:26243637"/>
    <dbReference type="OrthoDB" id="4484309at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI72747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="528" mass="60789" checksum="4AF4EDE7AEB541BB" modified="2021-02-10" version="1">MTKFEKILHRRLRASRVAIGVALGFTFLFIRFYHNTVDPFAQYAGNTMPCPPSRINEYAIKPPPAQDGRFLANLWDTLQPLFDQHKPDPAHITKPLVDKLPDKDILGSFFNLTNGEAENTRANHMELVKKLPPYPKGHFGGRGVVVLAGGRYSDFAATSIGMLRESGSKLPVEVWLNEDGDEAWCNELPLEGMVCRRLTDYMNLDDLPHPYQWKVFAMLYSTFEDILFIDADSIPVKNPDFLFDSAVYKNYGVILWPDYWKHTGSPLLPYLIGINSTRESDILASETSVESGQLVWNKKTHWKSLVLAAYYNYFGPDFWYTVFNNGWLGWGDKDTFPAALKAAQQDYYQVSHEIVTIFVQGTIDGIGMLQPDPTNKAEHKPLFLHMNMIKWGARDLLCTENCDKFKDQGDHPFHMIDERSQIYKHLREGMRVFAVGQLFQGNIDPEPDMWRVVEHNACRTSRANWHMCKNARSHMERTFGFDFTEYREEMNEGGNANTQICIEGPWVKPSRAKPKPKNWAKDYEETYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9I7</accession>
    <name>A0A7D5Z9I7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor SFL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SFL1</name>
        <name evidence="7" type="ORF">G6M90_00g072360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545827.1">
        <property type="nucleotide sequence ID" value="XM_014690341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9I7"/>
    <dbReference type="GeneID" id="26241860"/>
    <dbReference type="KEGG" id="mbrn:26241860"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="74"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="551" mass="60108" checksum="B9E2C41E6246B03D" modified="2021-02-10" version="1">MSTSASTSAPDAMDITSSPTASAPSHVADHETNGKLSNRPNQLPSNDRNPADSSSNMPAPPTVASSAVHQPKIVQTAFIHKLYNMLEDSSIQHLISWSSNAESFVMSPTADFSKVLSQYFKHTNISSFVRQLNMYGFHKERDVFHTGNPDTTLWEFKHGNGSFKRGDIAGLRDIKRRASRHALVHRETNFTKPGSSQPGTPAEPVQVPPESIDARLANLEHTLYDVSARLQRSEETAHYMHVKNQTVMETMGRLLHFNQELTRAMLSLVPLESTIHRDVMGLQGEIQRQADMIRTVDEPQDVPFVGRQQYFSNVDNPPVSPRQLPQDDSRRPAGGLAVPQSQARGQPLYRPGVPSSLTLGARRPYGSIGGSSTTQSSPLRNAAAPPPSGPHPLSNVETPPGNLARRHTAADIRAHGWQPGPSPFSASNAPPGPWPSSPGRVAPEDQRIRESLSTYSLQTASHSHPHSRPTTPPPPHAPANGSSNGADAFGGWSWNSAGNRDTKGPLFKDSSAPPTRRGSMAHILNPSDTAERSDEDEDPRGDDDRKRKRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9N8</accession>
    <name>A0A7D5Z9N8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Free methionine-R-sulfoxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FRMSR</name>
        <name evidence="3" type="ORF">G6M90_00g075280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545569.1">
        <property type="nucleotide sequence ID" value="XM_014690083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9N8"/>
    <dbReference type="GeneID" id="26241602"/>
    <dbReference type="KEGG" id="mbrn:26241602"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000048">
        <property type="entry name" value="Free methionine-R-sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000614">
        <property type="entry name" value="FRMsr_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01320">
        <property type="entry name" value="UPF0067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="69"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="186" mass="20032" checksum="E7F50584BE92682D" modified="2021-02-10" version="1">MVHADASNFAHGVTKDDAYEQVLMQAEGLFIDQRNWISDLGSNLANAASLLWHAYRSLPSPSKEVNWAGFYVLDPSSTKPRLILGPFQGKVACQTIEFGRGVCGAAATTQKTQLVADVDKFPGHIACDGDSKSEIVVPILASAGGSGVKKVVAIIDVDCTIENGFDDLDRKYLEDLADLLGRSCDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAG8</accession>
    <name>A0A7D5ZAG8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RFT1</name>
        <name evidence="12" type="ORF">G6M90_00g108460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987845.1">
        <property type="nucleotide sequence ID" value="XM_066131753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAG8"/>
    <dbReference type="GeneID" id="26243387"/>
    <dbReference type="KEGG" id="mbrn:26243387"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13130">
        <property type="entry name" value="MATE_rft1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="579" mass="63687" checksum="C5A20A3ECAC8F282" modified="2021-02-10" version="1">MASSPKDNSGHNANDASSPAVSQPTRPSMVKGASLLILLQLISRLITFVANQLLLRFLTPRLVGLSSQLEVYYLSVLFFARESLRVAIQRQGSTTAPSSKSDKQDEQLLVTRRDSQAVVNLGYLAIVLGLFVSTGLGWMYLAYANESILQTPYLVHSLYLYDLAAMVELLSEPCFVLMQRRLQFGTRATAESAATFLRCLAVFASTVLASRKRLDIGVLPFALGQLTYGVSLLLVYFVSGYGLATSIGFSLLPKAMAADSMAGADYVWSYFYRPTVTLASRMMIQSVVKHLLTQGDTFLISILSTPEMQGVYAMANNYGGLLARMLFQPVEESSRSYFSQLLAAASTTEKDAKDAQPSAAVQEAKKNLQTLLRLYTILSAIAVGLGPFAAPPLLSIVAGKRWTDDGAGDVLGVYCFYIPFLALNGITESFIASVASETEVQRQSMWMGVFSVAFAASAFVFMRVFPLGAQGLVLANIINMLCRVIWSSAFIKAYFRRNRSDISIRSIVPGEYFSNDIFCWNAFTLYGIGKPLNSNNARARYLTRFVRQIHMILLGLQSATPEVTYVTLQTHTHPKHPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAJ1</accession>
    <name>A0A7D5ZAJ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g091780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987502.1">
        <property type="nucleotide sequence ID" value="XM_066131406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAJ1"/>
    <dbReference type="GeneID" id="26245291"/>
    <dbReference type="KEGG" id="mbrn:26245291"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37726" checksum="AB6B17E74FC00B27" modified="2021-02-10" version="1">MGSHSLPSPPAEENKSGASRKSTSTKSVKSTSRVSKRASASAAAAHHHDHVTHAAGMDGRHKRCDGEFPCKRCKDDGLVCTAGVRKKVEYKQLPRGYAEVLENTQFALIATVHKLYNMVRNSQTWELGEPDLNDRGLPVIHDIAQKLGCIRPNSDIDLPVHSVFPEDEAGMAELARQLEEQQNKDGDSQKDLKDTDSSSYQRNDRASSSELDHSDFEDYRKAAFGSGNAMTLSPQSFAGSNDFDFSPTVPEMDPSVMFASQNQSMPNFSTWSMPKSQNSGLAMQHFLQQADALQSMNMMNQPMVDPEFGTIKPDILSCPNPDVMMGIGDPMIYGGFDSESMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAN2</accession>
    <name>A0A7D5ZAN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Minor extracellular protease vpr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">vpr_2</name>
        <name evidence="14" type="ORF">G6M90_00g067070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539573.1">
        <property type="nucleotide sequence ID" value="XM_014684087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAN2"/>
    <dbReference type="GeneID" id="26247656"/>
    <dbReference type="KEGG" id="mbrn:26247656"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028832083" evidence="10">
        <location>
            <begin position="23"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="164"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="12">
        <location>
            <begin position="419"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="13">
        <location>
            <begin position="631"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="945"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="983" mass="103984" checksum="BE41B452D97636D4" modified="2021-02-10" version="1">MVCSSWFAFLALGVIGASPAWAADNGIESTKLAADDLILECESNQACQLVANAVEASGGVLHYLYESDVFHGVSFQLPKSATAEERRALVAQFKCIKASWPVEDVNLMPEDIAKDQPEDKLQVLKGGEEKRAPFGRRADDDRVETPWNHLMTHVDKLHEEGYLGTGIKIAVIDTGVDYNHPALGGCFGPGCRVVTGENFSNQGNRSDPIDCSYKGHGTIVAGILAGYNKADGFVGAAPNATIMAYRVVNCEVQGREDDMIAGWLKAKEDGAQIIVSSVGFQGENWAQRPLAVVAARIVASGVPCIVALGNNKDKGLFYALNPSTGRGVTSVNSFGRSLVALEHRGEYSVGTGSEPVDFAFEPGTGLHDWDGEWRPVHDVDADFGDKPDDELTGAEEVPDYVDEDTVLGDNCKLSPGNSSTGFARDLAGHIALIRQTPETNGCHFDDRVRNAVARGAAHILAWQDAPNYIMIRRQDAHGVRAIGITQTDDGRAMARALASGQPLTARRAGRVRIDTGVVAPMSAYGPTWDMDIKPTIGAPGHQVPVTRKGGGYDSDSGTSFAGPLVAGVFALVAEARGTFDPALLNSLVTSTAEPQSSHGRLITVAQQGGGLLRAWEAAHATTLVEPSTLPFNDTDHRPDSIGLRITNAAKTEVTYRLSHLAATTLYTLEADSIRPSEDPAGELDKLAMMDDLDEVDEAVDAAAHVEMSQSSLTLGPGQSATVDVSATDPSGLDPERLPVWSGWVSIQGSDGTNLTVPYLGLGGSLRSAAVLDPASKLSTLAGSDFILPNPPEGQTPGPAQGIAEPAAAARSEAISTSFDLVLGSPQVRVDIVPLDVCPTPALVGTRANATEPDLPQACVPDSIVTEFAGAKSIGQLPGYPRHYVKREEIQIRWDGAFAPGQYAPPGRYKIVARALSIMGDAADEAHWQTVESPVFSILYEGNVKRAPENQPAQPAQTPEEEDAPAANAGDALAADEVKPAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAN4</accession>
    <name>A0A7D5ZAN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g097930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="77" mass="8773" checksum="ACD41C3CFC1567CC" modified="2021-02-10" version="1">MSEPNQTSPTTTSGNAPRRRSSGWMPAFESLQQQKNNQDAARRQSMSDQQAKGGIFSQFFHKYVHRPFVIRALSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZB17</accession>
    <name>A0A7D5ZB17_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g101470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_014690713.1"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:Cdc73/Paf1 complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46195" checksum="D148C1E3E4BC0716" modified="2021-02-10" version="1">MSDSEDPLDGLDETVGDDLFGDEGDEEPRAPRVLDDDELASDPDEDPDARRRDYDGEDGLPHETRDRVVMAVQTYRHQIPNPKDGILRVMRVPKFIKFMPEEYVSETFQPSDFDLANAKSDRPKHVARIRKDASTGDLQSNTNIYRWSDGSVTISVGGEHYEIQKKALAPGMDQPYNELNDGHNYAAAAELGSNLLLTVGHLTEQFNVRPNKAVGDDALSVLAERMAQASKSVNDGDMIIRTTRDPELQKKQAEMAEKERMKAQRRRENAALKMDGGLGRSGRGGLSIGDLEGGRGFGSGRKRGMPGSTKPKKRRPEYDSDDDLPQGVGRREDYDLDDGFLVGSDEEEMDSAAEEDDEDILDDDDEEERRPRNKRQRTADPDDDEDAEGDEVEPGEPSARARRRNIIDEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZEB8</accession>
    <name>A0A7D5ZEB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-alpha-acetyltransferase 16, NatA auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NAA16</name>
        <name evidence="5" type="ORF">G6M90_00g110260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543833.1">
        <property type="nucleotide sequence ID" value="XM_014688347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZEB8"/>
    <dbReference type="GeneID" id="26243220"/>
    <dbReference type="KEGG" id="mbrn:26243220"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI74489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="726" mass="81713" checksum="57562803C926B273" modified="2021-02-10" version="1">MPQQLAPKEAAQFRQVIRSYEDKQYKRGLKTADLILKKNPKHGDTMAMKALILNSQSKTEEAFALAKEALTADMKSHICWHVYGLLYRSNKNFEEAIKAYKFALKLEPESAQIQRDLAILQIQMRDFQGYIHSRNSMLQARPQLRQNWTALAIANHLAGNLAEAENVLTTYEGTLKATPSRNDVEHSEAVMYKNSLISAQGDCGRALEHLNTACKHNLDRLAVMESKAEYLAKLGRSEEAATAYRALLDRNPDHAVYYEKLASALKISPNGSRARKALYDEYAEKFPRCDAAKRIPLDFLSGDEFNQAAEAYLTLMLNKGVPSTFANLKHLYSDSVKKNALASLAEKYLQSESTLSTSKDKGEAAALYFLAQHYNYHLSRDLTKAMSYIEKAIEKDPKSVDFHMTKARILKHSGEIQRATEMMDIARKLDLKDRYINSKAAKYQLRNNENDRALKTVGLFTRADTAGGPLADLLDMQCVWYLTEDGEAYARRGNIGLALKRFHAVANIFDVWQEDQFDFHSFSLRKGQIRAYVEMIQWEDHIRDHPFYSRAALDAINLYVEIADKASTNGVNGNGGENGDDALAKKKAAKKAKKELQRLEREAAEKQAKQDPNKGTQSGEAKKKDDDPLGLKLAATTDPLGEAMKFLSPLLQACPRSIDAQHAGFEVYIRRRKLLPALRCLHSALAIDPSNPRTKEQCSVFEYTFKSIANLPQKVSEALTTEVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPJ1</accession>
    <name>A0A7D5UPJ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g010710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549448.1">
        <property type="nucleotide sequence ID" value="XM_014693962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPJ1"/>
    <dbReference type="GeneID" id="26238892"/>
    <dbReference type="KEGG" id="mbrn:26238892"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI63431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="257" mass="27532" checksum="2A7E16FED3028A8D" modified="2021-02-10" version="1">MATSPPPRRLVGLSAKMYFSLSRNREVTKGFLDCLSRTSLESLSNVDIFIIPDFVSLTETIGQLKSSPVPIWPGAQDCHWEDSGAFTGEVSPAVLSEAGVKIVEVGHAERRRLFGENDATVAKKAAAVSRNGMIPLVCIGEQTKGDIGVAVDECRTQVEAVLATVPSAAEVALAYEPVWAIGASQPAAEDHVLKVVQGIRRLDCVKSRQGTIRVVYGGSAGPGLYERLKSGLDGLFLGRFGHDPERFVKTILEVAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQH2</accession>
    <name>A0A7D5UQH2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartate--tRNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Dars2</name>
        <name evidence="8" type="ORF">G6M90_00g026900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547896.1">
        <property type="nucleotide sequence ID" value="XM_014692410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQH2"/>
    <dbReference type="GeneID" id="26237340"/>
    <dbReference type="KEGG" id="mbrn:26237340"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="193"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="694" mass="77300" checksum="610F8E7AA0F8E12F" modified="2021-02-10" version="1">MSQLGRCWAVSRRGACNRSILAPISRNGALRFYAHQTAAAGPRAGHLNKEELLKAWNQFRGSNSLTQTDPDVITGFLGKRRNVGKHLSFADLTTSSGEVIQICSHVDGGLESHEKFRQVPAFAPVVVCARPEPPAQAAGEEQNSSSSKRTLYLRDIRSLNTVPKDLIVTSDVQFPQTKRHLQIRFHPELQARLKFRSWLKGQLNQSLLEKGFTDVETPTLFKSTSEGAREFLVPTRQRGTAYALSQSPQQYKQVLMASGIGQYMQWARCYRDEDLRTDRQPEFSQLDMEWAFAGSAEVQADVNDILLAALSRLRPARSYSDIRGERIPILSDILNEPAPADESPDHKFTTLTFAESIAAYGSDKPDLRIPNQIHALEDIEPYRNFVNMITHLSDPLIEAFTFPLKDCSPSEARKFVIKFMDNLPPALANNPDGKPQILIHDSRQPLSGFSSLGFEYESVLDKLSQGQEISDGDLVVFQAREKPQGQYCLGSTKIGDIRNALWKSLVEEGYMEKPKLGDPESLQFVWVTEFPMFKPVEEGEPGQGGAAGISAAHHPFTAPLSENDLEILFTDPLQARSAAYDLVLNGIEIGGGSERIHVADIQEFIMRDVLKMTDQRIKDFSHLFDALRAGCPPHAGFALGFDRLVALLTDTSTVRDVIAFPKTMRGEDPFVRSPSKLNNEQLAPYGLQLMSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQJ1</accession>
    <name>A0A7D5UQJ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g008200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549687.1">
        <property type="nucleotide sequence ID" value="XM_014694201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQJ1"/>
    <dbReference type="GeneID" id="26239131"/>
    <dbReference type="KEGG" id="mbrn:26239131"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="435" mass="50203" checksum="F2FD98ED7880AB0F" modified="2021-02-10" version="1">MTTVPNSVAYLAGLPVEILLDIYQHLDLQSTLELSLTNTEFFLFFQRRKVDILLPILMRDFSPFDEFVQVYTASAEDIASGGLYNPRKVVLHRFAGDKGVVLSDGISLPSLTGNPVGANFTQVTHSRHALKASGPSPDTVHLTAVDLDGLLKQCRIVREWEGLFPQMRWFHQPEDCRFLRPHEQVRFRRALYRWWLYGVYFHGDFPRPRVGHPEPFVDDIRTSQMRRHSTGELMELMDFLETVKDMILQYICPRLDPNQQQTFTQSPLVEDVGRSQSLATSWSDQSHWGRIIKTYAKLGPEDLLYYFKNIYSYPRKRLITEIQLRHPNFSFDQESIQIAVRCALDERSWLDEMVNWAEHDVGGIIDFDDERDEDRPRLQNDASPTGELPEGSRFIQSYSRYSPRGDDGSLLDDYFRLSMVESRLAASSTLLGAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQX3</accession>
    <name>A0A7D5UQX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ndk1</name>
        <name evidence="15" type="ORF">G6M90_00g020640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548483.1">
        <property type="nucleotide sequence ID" value="XM_014692997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQX3"/>
    <dbReference type="GeneID" id="26237927"/>
    <dbReference type="KEGG" id="mbrn:26237927"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="14">
        <location>
            <begin position="107"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI64775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="257" mass="27801" checksum="1059F47243DD0AEE" modified="2021-02-10" version="1">MAKPHHNQQNPASGTHASRSASASSTTATCRNTDGGQQRNPLRRALETLPPPIFALPFFAFALAAIAIYFLSSRQVPAPNSVHSTPLDLLSIPASTYSNPKSTMSSAEQTFIAIKPDGVQRGLVGPIISRFENRGYKLAAIKLVTPSKDHLEAHYADLKGKPFFDGLIKYMLSGPICAMVWEGRDAVKTGRAILGATNPLASAPGTIRGDFAIDVGRNVCHGSDSVENAKKEIALWFKEGDVVSYKQSQFDWIYEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR71</accession>
    <name>A0A7D5UR71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sexual differentiation process protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">isp4_4</name>
        <name evidence="11" type="ORF">G6M90_00g015380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548989.1">
        <property type="nucleotide sequence ID" value="XM_014693503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR71"/>
    <dbReference type="GeneID" id="26238433"/>
    <dbReference type="KEGG" id="mbrn:26238433"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="142"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="490"/>
            <end position="510"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="516"/>
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        <location>
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            <end position="688"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
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            <dbReference type="EMBL" id="QLI64797.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    <sequence length="809" mass="90514" checksum="AF643E70B1482F1C" modified="2021-02-10" version="1">MSAELGQRRISAESTGFDAGAGPSSRLSFSHRRSASIEGLKEHMFQWGEGHGSDDDDVSEHELLMDPNLPDDEHADAIEMGTRSVRKRREEEDSLYPEVRAAVRNYDEDVPCNTVRAWVLGLSLVVVGASMNTLFSLRQPSISIGPLVAQIIAWPVGHAWARFMPKRSFTTWGFTWTLNPGPFNIKEHSIIGVMASVSFSVAYSTDIILAQRIFYKQNFGVLFQLLLTISTQSLGYGIAGTMRKFLVYPASMIWPANLVAVTMMNTMYEKNDVRDPAVFGGNMPRLLWFFLVTVGAFVYYFIPGFLAQCLSVFAFATWIAPQNAVVNQLFGGTTGLSLLPITFDWTQISGWVGSPLIPPWYAIANTLIGVIAFYVIGCSVLHFSGAWYAEFLPMSDANTYDNTGAPYNTSRVLSKDFTLDQEAYESYSPLFLSTTFAVSYGLSFAAISSLIVYTYLHNGKQIWKQYQNSANEKPDIHLKLMKKYKEAPDWWYMGLFLVMLAMGLFTVLAYPTKLTWWGFLLAVAISFGFSLPIGIIEAVTNNRIGLNVLTEFIFGYIQPGRPLALMIFKTFGYITMSQALSFVSDLKFGHYMKIPPRTMFWAQVVATTFSCFIQIIVLNLALTNIPDVCDQHQRHHFTCPGGRVFFSASVIWGLIGPDRMFSPGRIYSALFLFFVLGAIVPIVVYFGFKRYPKSPLQYVMAPLIFGGAGAIPPATPLNYFSWGIVGFIFQYWIKKRHFGWWGRLNFLTSCGLDLGLALGTLFIFFAFTMHGIEAPKWWGNEIVDSTMDAQGTAVQGRVASGQVFGPKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR83</accession>
    <name>A0A7D5UR83_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Superoxide dismutase</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SOD2</name>
        <name evidence="13" type="ORF">G6M90_00g009390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014694088.1"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_BS"/>
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        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
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        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MNSODISMTASE"/>
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    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="12">
        <location>
            <begin position="124"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="228" mass="24878" checksum="AF965E617925F575" modified="2021-02-10" version="1">MSSALLRTTPVVRAGLRAAKPMAMASTSFVRGKATLPDLPYDYAALEPFISGQIMELHHSKHHQTYVNSFNAASEVLAEALSTNDTKAAAAQGPLLNFHGGGHVNHSLFWENLAPNGKGGGGEPEGKLLTAINEDFGSFENLKKQTNATLAGIQGSGWAWLVKDKTSGTLSLVTRANQDPVVGNFEPLLGIDAWEHAYYLQYQNRKAEYFSAIWEVINWSTVSKRFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR99</accession>
    <name>A0A7D5UR99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g007110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549799.1">
        <property type="nucleotide sequence ID" value="XM_014694313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR99"/>
    <dbReference type="GeneID" id="26239243"/>
    <dbReference type="KEGG" id="mbrn:26239243"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="2">
        <location>
            <begin position="329"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="597" mass="66234" checksum="C059F947D9C6F7D6" modified="2021-02-10" version="1">MRGSRLIYDGLWRCLCPAVDGRALRRAVSSRAPGVVTTARAPSAIACTRLAQARHVTTASASASIQNQMVTRDAAQQTKHEVPREERLLTPAPPSEETLRQASVEEIVAALVTMRDAQGWSFHGQEIDRHDRVIRLVRHLLSARDQTPSPFIYECMMDAMVDPQGSVKGIRKLLDDMASQNMKPTAAMCHSALAALTNHPDYALRQEILDTMQEFWFTIDTPARQSVVLGLLRDEQYELAYSRLTEMIEQGAHIAIWVFDIFVMVFGKLGFVDEMMSLLYRRKSIQGEDRAISSILYYALDVCSSAFHYPGTLFAWNSAVRSSLFQPADGIVENVLATAARHGDASLATEALDMMSRRTRVLAYHYEAVAEAFAASGDMTGAFRILCIMKKNGIRIVRGNTRVVSEALRRHPKLMSDAEAALRAVAHDEQLPVAMVGVVVEALAETQGSEAAMDLYRDVACLCGEHANSTMMQTLIINSPDEETTRALVKDYTAHIAEDDDPVRDSHVYGALVTRCAEAGELDLAFRFANQALVAMGGSKTRRLDWAKVLVAKAAEVEDGRIWGVVDELRKDEETGALVERLLRQMRMTKRASELKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USA7</accession>
    <name>A0A7D5USA7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane bound transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g023400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548215.1">
        <property type="nucleotide sequence ID" value="XM_014692729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USA7"/>
    <dbReference type="GeneID" id="26237659"/>
    <dbReference type="KEGG" id="mbrn:26237659"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="740"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="687"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="574"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1074"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129936" checksum="5CFE6630FAA3EC1B" modified="2021-02-10" version="1">MAASNPFRSLVIAIWGDWQQNALWQRIVKYSLACTIATIIAILPHFKTTATFLIPMVVVFAHPGQRMGRMMEELLMTLFGALLGLSWSLLGLYLSSLVQDINAPAAYTIRALFLLVAVLIHGFVRSMSPRLFNFVLFLLVAALLTIQLPSNATTSLFTTIYIPILLGGGVLVVVNLALFPELSSSYLGSSTIETLSTTVDTLARATHWFITPGCDAPEAAKISSNALATTSTARTSRTMNRARRKTMRNIKAFAAEFPNPFHTGKSQATVATMPVHRTTMAFLTAQKSKLRSQLSRCKAAQDEVNFEISTSPLPPIAMKPISVRYMTSLVQNIITLIGNCENKFVLVGNEDHLGILPDYKESTESATPDFQTRTAQRIHPISPNRREASHHNEQVKIVKPVREIEAGSSQLLEMTIQRIRLPVQDFQSSIKEAVNLLIACLAYCFEVPKLPSGSPAPDGILLEEIDSRIDEFSACISAFDAGSAQALKKAIMDESGRAVDFMPRMETFLVSSFILALRDSATQILHMLRHVRTLVEKRQRRRNKFRVWVPQYRNIRKWLTSGGEADAMVLPKEAKKAARQGLQSPSSEEKAEPSSDEIKAPVPPNDEETCSAVASSHKTQEKQDSLSKPTRRDRKQSPHGRVAQFRSTIADALEWVQQSDDVEYALKLAIAIFLVTWPAFVSSSNAWYSEAKGVWAPMQLILVFEVAIGTSLFVFAVRLFGVIFGCVVGYLSVEIGRGNRVAAVVILLFGIVPSAYVQVATKYVKAGMISIVSLAVVALAAINETTAASEVFYKRLVAFLVGGLVAMVVETLVVPVRARDRLVESLSTAVRQVQKMQAAVAVGIDDPERPNFRSSKLLTRFSHSRDKAQGALAAAEMFLPFCLTEPRLKGSFKPLAPIYKEIIYVLHQIIDRMDNVVQLRRVYGSSILEDLNPKVYTYRRNVAASSTLILFSVHEALTTWLPLPQFLPSARLAQLRLISRIRELLIAQSPKGPKPNILAYHRRRPNLDEDTASLITQHKFLSWNASTSGQMEIIEYLEELVELVKLLVGVNAFRSGLLERPQYRQYIRQLETEQDEDLDRALSKSSHASTRVDGEGGGLELETLRRRATATGSQGISQPLGLSQVEGEPGRGTDDSEDEDEAIPRSLQRVGARLMRDDTVVRRRRFTVGHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USQ4</accession>
    <name>A0A7D5USQ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SDH8</name>
        <name evidence="4" type="ORF">G6M90_00g009470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549567.1">
        <property type="nucleotide sequence ID" value="XM_014694081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USQ4"/>
    <dbReference type="GeneID" id="26239011"/>
    <dbReference type="KEGG" id="mbrn:26239011"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="132" mass="14418" checksum="A99007B1ED7CA8DC" modified="2021-02-10" version="1">MQRLRPLRAILTRGTRTRTYSSFQTRPAPPKLPASQQAEFERLQREAAVSSAFQPANTGAPAESLSTQGQTQAQANTLTEEESVNPALFRGAPPEFDGDKNPKTGEVGGPKNEPLRWGGDGDWSYNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT73</accession>
    <name>A0A7D5UT73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-actinin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ain1</name>
        <name evidence="8" type="ORF">G6M90_00g014900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986089.1">
        <property type="nucleotide sequence ID" value="XM_066129763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT73"/>
    <dbReference type="GeneID" id="26238478"/>
    <dbReference type="KEGG" id="mbrn:26238478"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="193"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="307"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="667"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="843" mass="94676" checksum="F1C9360939F9DE16" modified="2021-02-10" version="1">MAALPLGASGDDAAGQLLERSPSPPPGNLEGAGQGSQFCLHNSSCSHLDGCTCVLDDDHLVRQFRDSISASTSRSSRSSTLSTASTSLTAADCDCTQSTATGPGCRSQTRSSLPGKRSRRDREQLQAARLQRSGRDGPPLGSKDKPSKHSKANWSRRRSGNTSGTADALAAVEPANEHSLVKMSTLEQQRWINVQQKTFTKWLNTKLVSRGLEVKDLVKDFGDGVMLIHLLESLSNESLGRYASKPKLRVQKFENANLALDFIKCRGIQMTNIGAEDIVDGNRKIVLGLIWTLILRFTISDINEEGMSAKEGLLLWCQRKTACYDEVEVRDFSASWNDGLAFCALLDIHRPDLIDFDSLDKHDHRGNMQLAFDIAHEEIGIPRLLDVEDVCDVPKPDERSLMTYIAYWFHAFSQMEKVENAGRRVEKFVSNMQGAWEMQTAYEKRMKELLAALRAQVKEWQLAQFEGTYADAKAQAKDFAAYKRGQKRDWVAEKSDLATLLGNIKTKLGTYRLRPYDPPAELSLDALERDWGTLAKAEMRRAQLINETIRDIKNALRKSFADKANDFAMALNTMQLAISGLDGDIEDQWHHVKKLSDNLAPLDRYLETIEAVDAKCYEANIEENDFTTYTYDELAYELGLVKSSVQKKLAFLENQMVARNMTNLTPIQLEEFESVFRHFDRDDSNSLHEIEFGAALASLGLVFSEEEMHDYFLETSGGRDEVTFEQFIRFMVDVTEDQNTAEQVFQSFREVADGKPYVTEMDLRHSLVPDEVIDKLVEMMPPHKGPDMSQDRGQPQFDYISFMEKMIDAEGTQDDVPSGVLQDRTNLGDTNPRKSPKANGFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTL5</accession>
    <name>A0A7D5UTL5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA-processing protein TSR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TSR2</name>
        <name evidence="4" type="ORF">G6M90_00g038410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547199.1">
        <property type="nucleotide sequence ID" value="XM_014691713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTL5"/>
    <dbReference type="GeneID" id="26239762"/>
    <dbReference type="KEGG" id="mbrn:26239762"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="205" mass="22745" checksum="2CF6184EAAB97964" modified="2021-02-10" version="1">MASSTDTGQLLPAAVRQSNFEQAVAYSLHLWPALTLAVQNNWGGPDSADKRDWFAGAIVDLFPEFSDAPQTKPIEEPDMEDVETVLLQVMIDEFEVNVDDDSGTEVAGNIVRARAECAIGQFDEVNKLNQRFQNLKGKKVDQMFTKAEDAHQDTDWESDDDDDDDDDDASDVDMDDAPAPRSAPKEKPAPQIDEDGFTKVTHKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTM2</accession>
    <name>A0A7D5UTM2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CGR1</name>
        <name evidence="10" type="ORF">G6M90_00g012000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986103.1">
        <property type="nucleotide sequence ID" value="XM_066129721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTM2"/>
    <dbReference type="GeneID" id="26238766"/>
    <dbReference type="KEGG" id="mbrn:26238766"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="122" mass="14675" checksum="4FF3AB3EAB8CBF7E" modified="2021-02-10" version="1">MSDDEAPTLVPAEGQERASKPLGMRKNGKQWHEQKKAFRPSKGLTTFEKRAKERAAMAQMKAKEKEMKEEKETMRKEKMEKIREKRAKKEEKERYEKMAETMHRKRVERLKRKEKRNKLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTQ9</accession>
    <name>A0A7D5UTQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DAD1</name>
        <name evidence="18" type="ORF">G6M90_00g049400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545049.1">
        <property type="nucleotide sequence ID" value="XM_014689563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTQ9"/>
    <dbReference type="GeneID" id="26242390"/>
    <dbReference type="KEGG" id="mbrn:26242390"/>
    <dbReference type="OrthoDB" id="5566853at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28025:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI66616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="93" mass="10624" checksum="25816DFD8313A3C6" modified="2021-02-10" version="1">MAKRQRTSETDPVREKSYFDQQREALLSDIALSFEHVLANINKLNRSLESVIEVGNEFSSVEALWSQFENVMAKDEAKHQGEKTEPPGDEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUE7</accession>
    <name>A0A7D5UUE7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of nonsense transcripts UPF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">UPF3</name>
        <name evidence="8" type="ORF">G6M90_00g034020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543329.1">
        <property type="nucleotide sequence ID" value="XM_014687843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUE7"/>
    <dbReference type="GeneID" id="26244130"/>
    <dbReference type="KEGG" id="mbrn:26244130"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="526"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="664" mass="69325" checksum="18B8844DAA1257B3" modified="2021-02-10" version="1">MSTQPPQVLSRKANGPSSSATSQPSDQIKVRQRVRASQAKDNDTGGNTLKPAKGKGPADRRGGASHKSANDGEVAPKAPRSKPQNEGEKLVIRRLPPGMTMEECISILGPEWEISKGKVDWFSYVPGKISIDPSKPSRPGRAYVHLVRKDDIMPLSEVVRNATWEDAKSTFTNPSLIGPPVLEFSIYKKVPGTKKRTDTRQGTIDQDPEFMAFLEGLANPAPMRESIDVEDADESAKVEVKVITTPLVEFLKEKKANRGKDGSGKNSKSGKGKSGAKDDDSFGRKKGKESRTEKQDKTPKENVKILTKKAATEQAAEGAKKVASEIATANAAATTAAAATDAPKSRRAGIAAAARILQRDLGLSPGSAHRRARHDAAKAEADAKAASSSTKDDNGTTADVANAASSTASAASPAEVIVQAPKSRPDSPVAPKPQAGRRNRGGKGGAEKGKPAANEISGPQPTVANPPVILRKKNDSETNKKTAEPQVQASGPVTNSNGNGRQAGKEKANSKLASQKKSPAVSANATRAFIKHVNASQGVNDAKLREALGVFGTITLVEIDKRKGFAYVDFSEHEALVKAVAASPVQVGQGNVQVVERKDKKLTAAAAAPGGSAKDDQTPNGEKEKEKEKAPGGRGRRGRGGGKAAAGTANGQATAGPTLASTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVE8</accession>
    <name>A0A7D5UVE8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fma1_0</name>
        <name evidence="14" type="ORF">G6M90_00g031320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543071.1">
        <property type="nucleotide sequence ID" value="XM_014687585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVE8"/>
    <dbReference type="GeneID" id="26243872"/>
    <dbReference type="KEGG" id="mbrn:26243872"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF15">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="13">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
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        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
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        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
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            <position position="369"/>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <note>catalytic</note>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="412" mass="45675" checksum="26426ED47BA49477" modified="2021-02-10" version="1">MVESSKMKCLGADCENDAGTLQCPTCLKVGLNDSYFCTQDCFKRNWNQHKTVHKIAQGKTQNGTLHNIIPPSPKVVSKCNEVARFYNPFPSYAFTGSVRPVYPLSPMRTVPKSIPHPDWSVTGIPKAERRLNRSKIDLLDAKGQEAMRKVCRLAREVLDIVAAELKPGITTDYLDEVCHNACVERKSYPSPLNYNHFPKSLCTSPNEVVCHGIPDQRILLDGDILNLDISLYHEGYHADLNETYYVGDRAKTDPDSVRVVETTRECLDMAIALVKPGTPIRDFGAVIEKHAKSRNCTVVATWGGHGINTEFHPPPWIPHYAKNKAVGVCKPGMTFTIEPILALGKSREVYWPDNWTNVTVDGKRTAQFEHTMLVTETGVEVLTARKENSPGGPIPMPATPNDTAKTNGATHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVS6</accession>
    <name>A0A7D5UVS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g048970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986495.1">
        <property type="nucleotide sequence ID" value="XM_066130453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVS6"/>
    <dbReference type="GeneID" id="26242349"/>
    <dbReference type="KEGG" id="mbrn:26242349"/>
    <dbReference type="OrthoDB" id="5398371at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="480" mass="54092" checksum="DF5C9BE0D986493C" modified="2021-02-10" version="1">MGESAPSADAESSDGPSKPSKRHIPPDVVNITPIGDIILSVTFETSTETLRKTRKAALSASRKASLPNGPSTPPQVLKPKVTIAYRVQLDMLKTHSQYFGNLLTNPQFREAKLITAVYADLAGRKIKTSEADPAELPHVKITDDDEATQSAGRESVFEDMLRIIHQVPIKTTRTVMSYATTLALLADRFDCRAPVSRALMEIKFKWPLTNTRPYLDESGRVTETEKVLRQKILVAWLLGQPMRLHQASRELVIRGSRLWGVYGEEDEAQGAWWHLPEGIEEELRYRRECILDTIASIQRHFLTLYASRNRQCKLGYDSSTACDSFQFGQMLKFLLSKDLLHLVDFSPSSVDDVPDTSMVDVDELLGTLKQCPNYQIDKHHTNCGLRIRIDPILDYVRAMVGAGVVAIPLADWKRRRADVSWLNEKEGLRNVRDAEEGSNAFAFTRALATDQRLRYEGALYADGMARRLFTADTWDWTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW39</accession>
    <name>A0A7D5UW39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="17">2.7.7.1</ecNumber>
            <ecNumber evidence="17">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NMNA1</name>
        <name evidence="19" type="ORF">G6M90_00g037860</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. May be involved in the maintenance of axonal integrity. Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="17"/>
    <dbReference type="EC" id="2.7.7.18" evidence="17"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547146.1">
        <property type="nucleotide sequence ID" value="XM_014691660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW39"/>
    <dbReference type="GeneID" id="26239709"/>
    <dbReference type="KEGG" id="mbrn:26239709"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000221">
        <property type="entry name" value="Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 17 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7 17" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="18">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI68355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="274" mass="30527" checksum="3546DDFA92BF3280" modified="2021-02-10" version="1">MASDFPYVKKMTPEGYVFPSHRLRRTCDAGRVPLVLVACGSFSPITFLHLRMFPMARDHARNEGYEVVGGYLSPVSDAYKKKGLAPANHRIRMCEIAAENTSKWLMVDPWEALSPTYIPTARVLDHFDYEINHVMGGIECSDGTRKPAKIVLLAGADLIQTISTPDIWDAQDVDHILGNFGVFVLERTGTELDSALAALKPWEKNIHVIRQVVTNDISSTKVRLLLKRDMSIDYLIPDDVINYIYDNNLYRELDLAGGSKGKEKADVTAGPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW74</accession>
    <name>A0A7D5UW74_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g044320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547766.1">
        <property type="nucleotide sequence ID" value="XM_014692280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW74"/>
    <dbReference type="GeneID" id="26240329"/>
    <dbReference type="KEGG" id="mbrn:26240329"/>
    <dbReference type="OrthoDB" id="4941478at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028906218" evidence="2">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="230" mass="22316" checksum="DA185D2714059FA9" modified="2021-02-10" version="1">MPGPKMNVLAGLVAALGVFVTGAVAESGVANGQVTKTLEPKPIGTATENGALLVSMNFCSVVVNTQCQVSVMTSAPASGPTFAPSSDLGLSRASAAAPVPAPVPAPAPGSAPPQAASVDAAATETSSPVETSDAVQPVVPIVPLPTRFSVPASAPASAGAESTEAAMPTETEPPNQPTIEMTNSSGTVTRPSSTGAPAITSSALAAAAADIKALPSVAWGALILAMAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWH2</accession>
    <name>A0A7D5UWH2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">M-protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aprE_0</name>
        <name evidence="8" type="ORF">G6M90_00g048680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544981.2">
        <property type="nucleotide sequence ID" value="XM_014689495.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWH2"/>
    <dbReference type="GeneID" id="26242322"/>
    <dbReference type="KEGG" id="mbrn:26242322"/>
    <dbReference type="OrthoDB" id="4960667at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="7">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="567" mass="63811" checksum="B5C21F2CADF02B51" modified="2021-02-10" version="1">MLPFRPHQLPRTTNPSQSRPVEEWINDIYLGSYEQGNDPAVDCMCLPIRLAPESRIRRFRNDESGTAFLMRRNVDGFVLASVMIVYAFPSISHEEMGREHEYINALADHHGQATMYEIGFLWVAPEMAVLLAQDYDMQNIVAAIISPLTCWRIMPHQTFSVIIFWDEEENLRAYIPDPQSMNGDDPGYIEATNLSEVFPTCKQTLSSASQQERNLGTTLFGYQNASAGADDRANIGADDFFTDGHHMKRVQSFFSTIRRPHQRRVKIAVLDTGLDINHPLLQKFVRSKQIGEELGRDFTMHPLGEPDLKDNTGHGTACTHLLLKTCPTAVVYTAKISNQSTFDEKTAERISEAIQTAITEWEVDIISMSLSYEFEVEIIDEALKNRQRDKKRPVLFFAASGNFGKDKGEHSAGFPARHENVICASSSTYEGNKSDFNQGPDDMNRWKNFSIIGENLCVAFSAELNRGNYEKRVSGTSMATPIMAGIAALVLEFCNIWKERGGRPTLEKAATMQGMLQIFRGCMLSNSNSSSQQGHLNLVPWYLFDGSSYTRDYASVGNHIAEALRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXB2</accession>
    <name>A0A7D5UXB2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Formylmethionine deformylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g059110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544484.2">
        <property type="nucleotide sequence ID" value="XM_014688998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXB2"/>
    <dbReference type="GeneID" id="26242896"/>
    <dbReference type="KEGG" id="mbrn:26242896"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF6">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="70973" checksum="4F58FF5B1750E794" modified="2021-02-10" version="1">MTASMSRPHWLVPSLMIGSLICGIAFALGHHFFYASLDSRIVQSSTQQEWNIRIGTGMAFLVKAFLTAAVGFAYTQFLWTTLASRNSTLEGIDAMFGVATNAWDFLSLELWRKGLGLVAVASVLWALPIVAVFTPAALTVQPSSESNKTIHRLHLPTLNFSDPQTFSIWGGDGMAGYEAPSIAVSRLVSSVASQGSIIPMKAPYPNSSFSTSFHAPSLSCRPMGGGPEFHAAFDKLFLNLTEPNFGAGSTEKSFFSFVPQHPLVLRKNETDDWKLRTLLGLQAILDKAGSAMLATVDSLEDPRSPCWFYVGFPIIQGYANRTIQCGLYNSSYDVEWKFSNGQQTATVRNMTRLNPVSTANADNKLMYYANGTPDVPYVAVMDALDALLMGWIQSSRFGVMWPSRTQILSTVLTQTYEMQHLRHSALKLVPIEPQSPHKTNLTMVEAMEQLVTNISLSLFSVGDFLNDETGSPIGNITSESPLNEYSYNPRNLYAAYGTGIFVTLVVVIIGLVCIAAASRSYKSNFSTILRTTRNEELDAVVTRGETTGAEPLSTHLGKTKLRFRYNPAEDSPSRGSAFSVVSGGKASSYEPPTGLLGSLRTISKTAKENLMNEATDETNGETKVVCFLAADTMADSLEGNQYEHLAWGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXD1</accession>
    <name>A0A7D5UXD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542648.2">
        <property type="nucleotide sequence ID" value="XM_014687162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXD1"/>
    <dbReference type="GeneID" id="26244597"/>
    <dbReference type="KEGG" id="mbrn:26244597"/>
    <dbReference type="OrthoDB" id="5399817at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028880858" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="120" mass="12903" checksum="ACF2187339F89151" modified="2021-02-10" version="1">MSKALQVTSVGWLLISLGHTASAKDWQENAKFQTLPRLAYACAKAGWYQGSGFFIMNALINYAWSKNPALLRDPVQKAVAGAMIAIMWASGWWYAKNGVTSNAVAVGAIGALQGYSAFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXM1</accession>
    <name>A0A7D5UXM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hrf1</name>
        <name evidence="11" type="ORF">G6M90_00g060080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544577.1">
        <property type="nucleotide sequence ID" value="XM_014689091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXM1"/>
    <dbReference type="GeneID" id="26242989"/>
    <dbReference type="KEGG" id="mbrn:26242989"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="35718" checksum="40B74C9F82DC544A" modified="2021-02-10" version="1">MQRGAYGQSPPLHHPVPQHVSTVPQLRSPPPPPGSAQSMGQTYGGASTPYQQQGGNSGNVFGAYGQFMNDPTAQVAAQFGQTAFKHGQEYVEQNIGRYVNVSALKHYFNVSNSYVVNKLFLVLFPWRHKPWARKQATGASGQEGWYLPPRDDVNSPDMYIPVMALVTYILLSTLIAGLKGQFKPELLGYTATTGMVVVIVEIVALKLGCYLLSISSQSQLLDLIAYSGYKFVGIIATIVVAEILNGGKGTGGWIGWGVFLYTFLANSLFLMRSLRYVLLPETSGNTGGPMQTDSRAKRNQRTQFLFFYSYIVQLFFMWLLTMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXW6</accession>
    <name>A0A7D5UXW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g061170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542751.1">
        <property type="nucleotide sequence ID" value="XM_014687265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXW6"/>
    <dbReference type="GeneID" id="26244700"/>
    <dbReference type="KEGG" id="mbrn:26244700"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="423"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="531" mass="63118" checksum="C8E455C1FAA54F45" modified="2021-02-10" version="1">MSQRGARATDFEERDYYPAPRRSGTRFEEADYRTSRVMTRSPPPRERESDRGISFLRDDARRSEPGQMVLRKRDVETWDVHRSPSPPRVREQRIVHRPRSESPRYHDHEHERSRTRVVERERERVRSPSAVRMRSPSPGVRFVERRRRSPSPPVREHIRTRIVEREKAKEPSPSPSPSPPPVIRGPTIEREVITHYTDVDHGVIRARPPSPRPHTHRERETDIDISLSKNKTEVDVDIHRSTSRHRSGSHERRSHYHDDELIVRDGMDRLRIDDGRRSHRRARSAAPMASPVDEEAEYMTGRIDARGRMGEAWHGHTKDWTIVDVPPGTERVRMDGVGGASTETNWSKYSGVRRTTFVPERDGQLVAVPRAPSPRPAPVPVVGRDHTSVTVYDRDRDREIDVDVDIDRRPGKPKPAPAPLPTRDMWTEITKDLVCREAIEQMGYSYEETKWFFYIMEYLQYDEVFQLTQLTERIRRHRRHHREVEWERDYRDDWHHRYRRHHRPRHEWDDERVREREVVYESRGPARGYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXX7</accession>
    <name>A0A7D5UXX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Vps45</name>
        <name evidence="7" type="ORF">G6M90_00g057930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986756.1">
        <property type="nucleotide sequence ID" value="XM_066130652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXX7"/>
    <dbReference type="GeneID" id="26242785"/>
    <dbReference type="KEGG" id="mbrn:26242785"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="577" mass="64607" checksum="3599829115F0E57F" modified="2021-02-10" version="1">MDVSQAISSYISKIVMPSGDASSTKMKILLLDRETISIVSTAVTQSSLLNHEVYLIDRLDNTGREKMRHLRCLCLLRPSSESIQLLIDELRDPKYGEYYLYFTNVAKKSSLERLAEADDHEVVKAVQEHFADYTVINSDLFSLSVSLPQWRIWGPNPDAWNADSLQRCSEGLLAVLLSLKKKPLIRYEKSSPLAKKLASELRYLMSQEEQLFEFRKVDTPPILLILDRREDPVTPLLTQWTYQAMVHHLLGIHNGRVDLSNVPDIRPELREIVLSQDQDPFFKKNMFLNFGDLGSTIKDYVEQYQSKTKNNANIESIADMKRFIEEYPEFRKLSGNVSKHVTLVSELSRRVSAQKLLEVSEVEQSLACNDNHNTDLKNIQNLIQTPDITANAKVGLVALYALRYHKQQSNAIPMLVDLLVAAGGVSPAQSSLVNKILAYHLSLHTSPSQGGISDIFDSAGIFSGASSRFKLKGVENVYTQHTSLLESTLQNLIKGRLREQQYPFVEGGGSTRDKPQDVIVFVVGGATYEEAKMITGINATTPGVRVVLGGTSILNAATFFNEVDDAVSSWPEVTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY76</accession>
    <name>A0A7D5UY76_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">External alternative NAD(P)H-ubiquinone oxidoreductase B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NDB1</name>
        <name evidence="11" type="ORF">G6M90_00g073320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545732.2">
        <property type="nucleotide sequence ID" value="XM_014690246.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY76"/>
    <dbReference type="GeneID" id="26241765"/>
    <dbReference type="KEGG" id="mbrn:26241765"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="691" mass="77693" checksum="A48F0B9032A3E228" modified="2021-02-10" version="1">MRARILTQTATGLVRPARTQQSNHSVVFRRKHFIATLSRGSPSHARTRINAGFQPKVLASIRHNLNASVHCRSLSGKPLPQVNSWVLNFCYRAGAWLGISITVLGIGVIAFFLYDATTYKHEREQSDINISQLALQPRRGGPNNLPIAEVFIDDDDCEEKKRIKDKPRLVVLGGGWGGVALLKSLNPDDYHVTVISPTNYFLFTPMLPSATVGTLEFRSLVEPIRRVLSRVHGHFIRAKAEDVHFSDKLVEVSQLDSRGKEVRFYVPYDKLVIAVGSVTNPHGVKGLDNAFFLKDINDARKIRNQVIRNIEVACLPTTSDEERKRLLSFVVSGGGPTGVEFAAEMYDLLNEDLTRHFPRLLRNEISVHLIQSRSHILNTYDETVSKYAEDRFARDQVDVLTNSRVKEVCPDKIVFTQKQEDGSLVTKELPAGFVLWSTGVSPTALCKKLAHKLGNVQTNRHALETDTHLRLNGTPLGDVYAIGDCSTVQNNIADHIITFLRTLAWKHGKDPETLQLHFKDWRQVAHDVKKRFPQSVNHLKRLDKLFAEFDKDQSGTLDFGELRELLNQIDSKLTSLPATAQRAHQQGYYLAQKFNKLAHLSEGLSANDIRDGDLDAAAYKAFEYHHLGSLAYIGNSAVFDLGEGWNVAGGLWAVYAWRSVYFAQSVSFRTRCLLAMDWAKRGLFGRDLMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ81</accession>
    <name>A0A7D5UZ81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ALDH</name>
        <name evidence="8" type="ORF">G6M90_00g071030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545954.1">
        <property type="nucleotide sequence ID" value="XM_014690468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ81"/>
    <dbReference type="GeneID" id="26241987"/>
    <dbReference type="KEGG" id="mbrn:26241987"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="494" mass="53366" checksum="3C5165B4167FA8A5" modified="2021-02-10" version="1">MSTINITLPNGVKYEQPVGLFVNNSFQHASGDKFDVVDPATGQQVLSVAGASVADVNTAVEAARKAFEGPWSELAPAERGDFLMKLASLIDRDRKLIAAIDAYDCGKPYSVALEADLEESYNVFKYYAGWADKIYGDTIDTSPAKFAYTVQEPLGVCGQIIPWNFPFMMLAWKVAPALACGNVVIVKPAEQTPLSAMYFGKLVQEAGLPPGVVNVVPGLGPVAGKTLAEHTDVDKIAFTGSTNTGRAIMRYAATNLKNITLECGGKSPLIVFEDADLEQAVKWAHVGIMDNSGQVCTSTSRIYVHEKVYDDFVKAFTEFTKKSTVIGNPFKENVNHGPQVSKNQFDRVLSYIEAGRKEGARILTGGLKVEGEGYYIQPTIFSEANENATVVREEIFGPVVVIGKFATEPEVIAKANDTSYGLAAAVFTENISRGHKVSRKLQAGMVWVNSSGDSHFGIPFGGYKASGIGRELGKYALDAYTQTKAIHVNLAMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZA0</accession>
    <name>A0A7D5UZA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987043.1">
        <property type="nucleotide sequence ID" value="XM_066130895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZA0"/>
    <dbReference type="GeneID" id="90967905"/>
    <dbReference type="KEGG" id="mbrn:90967905"/>
    <dbReference type="OrthoDB" id="4956826at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="23007" checksum="14D4FBA52365F4CC" modified="2021-02-10" version="1">MRQTSYSIHRLVHAWGYDRLQGDERVQRFWYAASQLLNNYLKVIGDRKAGPASKLRVVSHLVDNVQSFRRVSTVFDRDQVGLLEAVESFGIFFEEIGRWNEAALSQNEVLEKRQRILGDEHPDTILAMSNLAIMLGDQGKLDEAVLMKRKVLEKRKRILGRSIPIRVGRRKVYVLFNPRSAQSHLILRRPRNEGRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZB0</accession>
    <name>A0A7D5UZB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nae1</name>
        <name evidence="6" type="ORF">G6M90_00g073100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545752.1">
        <property type="nucleotide sequence ID" value="XM_014690266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZB0"/>
    <dbReference type="GeneID" id="26241785"/>
    <dbReference type="KEGG" id="mbrn:26241785"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="22"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="540" mass="59424" checksum="C331C5F710C8F13D" modified="2021-02-10" version="1">MSQEGSVIRGLQHGPTEKERKYDRQLRLWAASGQAALESANVLLVNSGPGTVGIEALKNLVLPGIGKFTIADDAIIQEADLGVNFFLDEACLGKSRALCCAEYLVELNPEVSGNCFPEEDDPFDLEKLTASSEPFTIILYTSSLQKDLVCFLESYAERRKIPILSVHSVGYYSYFTLKLPAHLPVVDTHPDEDATADLRLLDPWPELSTFVSQLTKDIDDQTDHDHGHLPLVATLLHCLEEWKDAHQGNPPLAYSDKLAFRNLVANGARRNNPEGGEENFEEAVAAVMKHVTPFSLPSSLKQIFDYGNSTEISSSDSFWIIAKAVEQFYEKHHQLPLSGGIPDMKAESAVYIKLQSLYKAKARQDASEVMSTVRTLEGGIGVAQAEVELFCKNAKFIKLVQSSVHAPTLTKIVENELLNDELSAVAGPETPLSLISIYLALRASTLISTDSAEEIVDFVASSIPSLSGNNRLLQVAQEVIRSNRGEVHNTAAITGGMVSQEMIKLITNQYVPIDNTCIFDGIESRCQVLRLNLSEHHFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZE3</accession>
    <name>A0A7D5UZE3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nonribosomal peptide synthetase sirP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sirP_0</name>
        <name evidence="4" type="ORF">G6M90_00g052400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986770.1">
        <property type="nucleotide sequence ID" value="XM_066130539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZE3"/>
    <dbReference type="GeneID" id="26246730"/>
    <dbReference type="KEGG" id="mbrn:26246730"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="36347" checksum="EEB536D90D5D13E7" modified="2021-02-10" version="1">MPPGEFDVISLEDVQRCYVPEADEASIDKSVVTEAESAPDQLAYIIFTSGSTGAPKGVMIPHRILVNYGQQTPFNLDAGQSDRVFLPFSPAFDGYPRPGSSQLLRPTETTCTSLIQKLTPSEPVVLGHPIVGSDVILLYKFFENRTKESFASAALASPTQERYYRTGDIARRTVSGIQFLGRNDFVVKNRGFLINLGADVKPALLSCPGVDEATAIMHRDNRIGFVTPGAVSGPKIREDLAARLDAFLVPERIYPLDRFPVTANDKVDPRALESWLNEQTKSVDDQTSTSDATSTPFETLVHALSSALSIAPQQEALASSSWGLAEILSRLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZR5</accession>
    <name>A0A7D5UZR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyamine transporter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TPO3_1</name>
        <name evidence="11" type="ORF">G6M90_00g071910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987102.1">
        <property type="nucleotide sequence ID" value="XM_066130961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZR5"/>
    <dbReference type="GeneID" id="26241903"/>
    <dbReference type="KEGG" id="mbrn:26241903"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
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        <location>
            <begin position="90"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="550" mass="60490" checksum="DB9469584C49BAA5" modified="2021-02-10" version="1">MSTSNYNDTLSGNLIPANAVMNPELLRTGSGSGPQDVEPQQQNDRNSVIQDLSSPDAIQRTGRSDQSYTVIGWDVNDPENPHNWSFFKKTYILTVTCMLVTNSTMGSALPCMAIPQIIDEFGSVSQEHKVLLISIFLLGYVFGPVIWAPLSEEYGRRYLTTATFFAYCLFTMASALSPTWSSLLGFRLCSGVFASAPIAVVAGILADIYGDARTTVFGPIFGPIVSGFASPTIGWRWTFWIALLYAGLTFIMLIFLPETHHQILLARRAKKLRQQSQSATIVAPRDLETTDLPQLVSRVLTRPLRMLFFEPIVAATCSYLALAYAIFYMSFQAFPIIFLRRYGLSPGITGLCYLPIGAGAFLSMVCFWSWDAYVARASSRGAVWATTDEYRRVPLATVGGPLFVISLFWLGFTAKPSISFVVPMLAGLPFGMGFQLIFMTLLNYLTDAYEVYAASANAAASATRSCLAVVLPLATRAMFNQLGISGACAVLGGLSAAMSVIPFVFLWKGQAIRNKSPFCIALRQMKEDSLRQEEQNRLEKDKEANRAHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V050</accession>
    <name>A0A7D5V050_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g069200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130900.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26246709"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="518" mass="58572" checksum="4778CA6268DC81F5" modified="2021-02-10" version="1">MESTTPFKESYELGYAQIQLRNLTFPFARDKELAAVDCLAAIFKERCDPDAMENQIPVFVSPSELALILTQTPGIELETLAHGQPPFPRLKPTGNVRCLHGRQRYEAAMRNFGPEKWWSVRIFRIPEGSDPEILLLRHIDHSSHQMKLSDGDVFRHVFACRRMRQRENENYWHLHLSKDKKGALKRILEDEVMSELLYELTDYPGLRNGWQLGNIDKHFADRCPEEIYNYLRHIKETWRKITLNNSDVRMATDNETVKELTLLCPSASYADNDKVRLLMRSGKLFGSISDSHLRGQIEQQLLGIGVVIPSIETFHGNMKYLRVANNLFLPRMLRENEICLYPSTMFVQCDFMRSFFAGFPKENSVIDQDTILRAHDLHLSSTSTPAAPVEIQQQSAITDLEGLDVSYSQLGSDSAVISAAQSALNRRRMRQPQSESPPSILVPDVQQASSPSNCSSLDLTDCPLNEDGSTPSFGTPPGRTVTTSIGSQLTQDSATTGRTMISPGDIMEYMRIDKVGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0G1</accession>
    <name>A0A7D5V0G1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase family member 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acdh-11</name>
        <name evidence="7" type="ORF">G6M90_00g075140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545582.1">
        <property type="nucleotide sequence ID" value="XM_014690096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0G1"/>
    <dbReference type="GeneID" id="26241615"/>
    <dbReference type="KEGG" id="mbrn:26241615"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="206"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="338"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="649" mass="70648" checksum="ADEE30088345B363" modified="2021-02-10" version="1">MEPSGADKGFFQKAPVLRNQFHDDASFQRCFKCKLPPLLSPSSLPIVFLSAEVASKAGGEVSSFGQDVISDQIFTWVTDSEHNKPYLKGSGRDAFGKWKGELITGEGWRSLQDFGLSKGMVATGYDTPYGAFCRPLQFLRTHLWVGSCANVGCPSAMQDGAACLLRRHLSHPELSAALSAAEKKVFTDAYQRLTSRDPKYAWTSGQWMTERTGGSDVSLTETVATYQPEGANGFASKQGQIPLGPWSINGFKWFSSATDSEMTVLLGRTAAGGLSTFLAPMRKHDPEATTLTGEPRDDGRALNGVRIQRLKNKFGTQSLPTAELVLDNMRGWMVGREGRGIHEISTILTLTRVHSAVAAVGGVGRGLGIARAYALVRDVGAGGRKRTRLVDSPLHMRTLAKISAEYRRLMLVTFYTSYVLGVSEHSLGARPSPALDALTPQEKLVEPLLRIMSQLAKAYVCKPSVALLFSCMEALGGVGYLVNEEQEYLNISRIYRDTCVLPIWEGTTDVLCTDLVRAMKHARGGADSLAALDEVVRKAWGFEGRAGRPAGWEPVEKWAALKSKIEGTEQADLMGEAREVVWQLGDILASVLLYVDAGTDGNPVAKEVFVRFVEDKFGVERRARGSTEDELNKDLGIVYGHGGDVAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0P6</accession>
    <name>A0A7D5V0P6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein FMP32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FMP32</name>
        <name evidence="12" type="ORF">G6M90_00g085710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987382.1">
        <property type="nucleotide sequence ID" value="XM_066131276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0P6"/>
    <dbReference type="GeneID" id="26246119"/>
    <dbReference type="KEGG" id="mbrn:26246119"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="257" mass="29130" checksum="824CC0AC001954E6" modified="2021-02-10" version="1">MATEMLPRFLLPRLSWNAPLTASRATRPFAALRAASTAPPWQSSLTSFNGESSPRRPSPAKPSPVLSRLFHATAQRQRDHHFDTLKFVKRLQGEGFTEEQSVAMMKMLNDVIEESIQNLTRTMVLREDAAKATYTQKVDFAKLRSELLSADSTETNTTRSSHERLTNDIAKLSSRLRDEISRTQASVRLDLNLEKGRIREEAVGQELKIKETETKIEQEVAALREKLEQVKFQTLQWLMGVCTGFAALMLGAWRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V147</accession>
    <name>A0A7D5V147_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AP-3 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AP3M1</name>
        <name evidence="8" type="ORF">G6M90_00g075620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545537.1">
        <property type="nucleotide sequence ID" value="XM_014690051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V147"/>
    <dbReference type="GeneID" id="26241570"/>
    <dbReference type="KEGG" id="mbrn:26241570"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="197"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="544" mass="58584" checksum="C5388AC470B441A6" modified="2021-02-10" version="1">MNGLIEALHIYDDNRFEYHDPLTPSASAKRPRKPILSHTYTGRPLSAKHLLPLYLEHPVPRPNLIYLPNASPATLIFSLTHANLLFLATSSTEIEPLLVIEFLHRAIDAFEDIIAAPLLASEIERNYHVAAQILTEMCDAGTINTTEPNALKENVEMEGLLDKIFGGFNLPSKTPISLNLSNTPALPWRSANVRHTSNEMYADVIETLSVTLAPSGRPLAAFANGSIVFTAKVSGVPDITVNLSSPSGKHNVGGIMELPVFHPCVRLNTWKERPGELSFIPPDGRFILAGYEVDLLPFTSGKSGSLSANNLKLPVNLEMKTGLGPAGLEFEVRLQVNKILGSQSTSGPGQFGRGIGSGRVGPPHAGSPGAPLLEGLSVTIPLPEDVRNLSDIRPSRGDASFNPGERVLEWQVPTKELSGSTSSLALRCTVVGPIDDEVQDFDPSGFAFNHDYSYNEPYQSAPAKAGGKTGNSHEQDAKKVAQNKILMPSSASVSFTVKGWLASGLKVDSILLDSRKSRGMAEGVKPYKGVKYLTVSKGGVEMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V179</accession>
    <name>A0A7D5V179_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mrpl31</name>
        <name evidence="2" type="ORF">G6M90_00g086420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542472.1">
        <property type="nucleotide sequence ID" value="XM_014686986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V179"/>
    <dbReference type="GeneID" id="26244986"/>
    <dbReference type="KEGG" id="mbrn:26244986"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12988" checksum="3CEDE27D5B6F06FB" modified="2021-02-10" version="1">MFGPFRITNPLSGGLLWKIPWRLSRFQKRRHRLRLRAVDSVVATLDSALAKKGQTLEALERWKAEMPTEAEMLPKDKYTLFDRKAKRYRKGIHKLPKWTRVSQRVNPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1S1</accession>
    <name>A0A7D5V1S1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539452.1">
        <property type="nucleotide sequence ID" value="XM_014683966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1S1"/>
    <dbReference type="GeneID" id="26247771"/>
    <dbReference type="KEGG" id="mbrn:26247771"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="103" mass="11323" checksum="D89B06BBFAB8AB0A" modified="2021-02-10" version="1">MSDAAAPCSIQVQDVFGAAVAESCLRGFDFTLLFEETILTVLPLGIASMLALSPLCFVLDLAVLGRGALTTNISKFFWLYYVYQPSGIALKRHRDHGFSFSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V246</accession>
    <name>A0A7D5V246_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g082060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987518.1">
        <property type="nucleotide sequence ID" value="XM_066131190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V246"/>
    <dbReference type="GeneID" id="26243615"/>
    <dbReference type="KEGG" id="mbrn:26243615"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="354" mass="39005" checksum="28612610861B7EFF" modified="2021-02-10" version="1">MVSLWPWKGTDSSPASFEKTLSSLSSKITTSQARLDRLHTSARRTKVLWTLYLSFAYLVYAIVLLLVVGYKNLGAYEWTGMAGGPILIYVARALISAYFNFRIDSLATRLKGYQDERANTIQKLKDATKYDSTMELIEKYGGEKKKRDKKDTQEDKQDQDKKAKRSPPPSGTGRTNLPPPPTANIVRPDAQQQPQPPPPPAQQHEGDAEFAPNAYASPPPPRTQYMDAETHWYDRIFDVLLGEDETAAKNRLALICESCRLVNGQAPPGTKSLAEVGMWRCMGCGKTNGQVDEGKRIVEEVLQARGQDGAEAEPEAANDAEESESENENEAGSKVKVTGSQGPAGSVKARGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2G3</accession>
    <name>A0A7D5V2G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541761.1">
        <property type="nucleotide sequence ID" value="XM_014686275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2G3"/>
    <dbReference type="GeneID" id="26245624"/>
    <dbReference type="KEGG" id="mbrn:26245624"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="79017" checksum="9883D3B211298EF0" modified="2021-02-10" version="1">METRTRGRRRDNPVPEIAGSPQQQMSPRTTRRTTATAKDTITFVGYYGSLSKDPIPRRGAQQRNDAASIASLSSRRKTRSEIAEDEDEELESSQPQPGGDSLQEDSLSPDDVEKHQIMASLLSDFTRATEELQRRLVNGDYQNKVFAAVLKSKRSTFHSILENYLKSKEFFSFIDLSWVERLSNRTDGDARILNASSCANIVTALDGIQHIKDNTVEDILPVLKGLDSAFMHLFTSEDSTEDHWKLALDLRTCYFIEALAAQGAQSDLEQTVVSVFCKDTDSKNYAHILTHGPFKSLTRNHETETSDDEDELISKRASELYTIAFQNKKDHGLGQLRESWPLDRTLKELSQCLVQWYVNSKDAERGQRAGLNEQTEPGRESWHDAEETIPDSVTESQPIMRPTGEEPKGASLFQGAKSLRDLQPGPNRNQVAPPSNQQHHNKTSSPIPSDYPEDETRDLLRSDVIRDPARAQKRKRNNNDDEADDDYDDDDDDDFEDDTREVPPSRVSQIKAQAAVQAAKRQRLPTNPPSRSMPPPPRPTSSQPPSTAEPDFEIIKKLKSEAIARARARALDSSQHLSSSAHPPSSAITTHAIATPAKQRYVWSNRDCNVLLRLIKERHAAWAAIEREHSSEFEHPRNQQAYRDKARNMKVDLLIMDAVLPTGFDLVTLGKKEIARLLSLGKNPYRREHEQENGMALNTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2I8</accession>
    <name>A0A7D5V2I8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pdb1</name>
        <name evidence="12" type="ORF">G6M90_00g082790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543501.1">
        <property type="nucleotide sequence ID" value="XM_014688015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2I8"/>
    <dbReference type="GeneID" id="26243678"/>
    <dbReference type="KEGG" id="mbrn:26243678"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="384" mass="41497" checksum="DDB76B90B08A808D" modified="2021-02-10" version="1">MSRILRPAARLALSSRAAAIKTPAAAAFTQTPRAVTTPVFFGAQQSRKYAEGAGVKEYTVREALNEALAEELESNPKVFILGEEVAQYNGAYKVTKGLLDRFGDKRVIDTPITESGFCGLAIGAALSGLHPVCEFMTFNFAMQAIDQIVNSAGKTLYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSVPGLKVVSPWSAEDAKGLLKAAIRDPNPVVVLENELMYGQSFPMSEAAQKDDFVLPFGKAKVERAGKDLTIVSLSRCVGQSLVAAENLKKNYGIEAEVINLRSVKPLDIETIVKSVKKTHRLLSVESGFPHYGVGAEILALTMEYAFDYLDAPAQRVTGADVPTPYAQKLEEMSFPTEKVIEDYAAKLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2M8</accession>
    <name>A0A7D5V2M8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g079580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987251.1">
        <property type="nucleotide sequence ID" value="XM_066131135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2M8"/>
    <dbReference type="GeneID" id="26247268"/>
    <dbReference type="KEGG" id="mbrn:26247268"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="33062" checksum="B6B2BFD6F418E60B" modified="2021-02-10" version="1">MATEIMNALKTLAAPQDQSKCKSFLVALRSICTKPKVQDLLDRLDRLQTQMTRYIQFSTRLYQVTNLSATIARLEATNKLIQVQRRQDLQRLKEDLIAAVSHCYNQELDSARHNKSAPVTSGDLQQPQLAAKRLSEAGQTTSKNQQVLEALYFRTLPSRSHQIAPAHAETFKWAYFNNPKRRLKFRECLRRGRMFSGYMTSRARSHWARQKRLVLVKFLFGNAGEALQKSQADTLRYVFFYILRQCPRLIPAARLAMPSWPRTVFDDEFGGDGFWTLKLEDLTSGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3D4</accession>
    <name>A0A7D5V3D4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SOU1</name>
        <name evidence="7" type="ORF">G6M90_00g104040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541400.1">
        <property type="nucleotide sequence ID" value="XM_014685914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3D4"/>
    <dbReference type="GeneID" id="26245650"/>
    <dbReference type="KEGG" id="mbrn:26245650"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="278" mass="29988" checksum="C6649E3FF8023FB1" modified="2021-02-10" version="1">MASPDQLQNVRPMFELRNRSYIVTGGAQGIGFACTRAICEMGGNVAVFDIQPEPVAEFSTLSQRFGVKTTYIQMDVTNEDSIKTAFDKALDSLGTIDGCVPAAGIAIDKPFLDQTWDEFTRIQDINVRGSFFVAQLTARQIVKQGTEGAMVLIASQSAHIALPGYRMAAYNASKGAVLMLSKALAVELAPHGIRVNTISPGFVDSDMTRTVREGKRSAREGEQMWLAPPNQRLSTQNDLTGAVVYLLSDAARHTTAADIQITGGLHAGTIDGLISYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3X9</accession>
    <name>A0A7D5V3X9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g111700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543697.2">
        <property type="nucleotide sequence ID" value="XM_014688211.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3X9"/>
    <dbReference type="GeneID" id="26243084"/>
    <dbReference type="KEGG" id="mbrn:26243084"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="95"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="653" mass="72513" checksum="45898AFA1DF74F2E" modified="2021-02-10" version="1">MHVPRAGRPAPGRTDASLTPPSVEPSARGRYCRNRLAPNAEQTPSDTIVDMPSDSYARHLRSCDYESQSMRASHGHGFNPDPCHLPPRTVGLCLLEIYFARIYNANLLFYKPLLFQEYLEDQVPAVLLQAVFALASLFLAPRDEADDISADFSELRAFATYHSRSLLWAKAATKEAMAAVMEAPSLPAAQALVCLTLYWFGTGDSKSADLCLVLAYRFCTVWNYRRQISEGAQSLDTSLESELKRRCFWACWASMCIVAEPEPIFKDAWSEAALLPLPSVISNGPSGWQVTIGEYMDSEWSLMSEFNQLEPGKEAPPSAALIKMIGIWARVQLFVTKSMHYSSTEKMNALSSLAAQATSMRHSIVPGPYSNSTRRGKLDSRQQFMVIDAFYCLCHVALHSTIVPLFSGSPLDQQISAEDVRHSAQAVLYHAESFTSSLADCFGGELDVTYLPPVVGYGAFLTGSVLLAFEISYQDKDVRLQKHSRMSAVQSIVTMLDTLCTYWKCLRRPCEKLRKAANAAMCHDPRAIPAGPQTSFHTQYGPRSTVHDRRYSGNPSSPRPPLHGAPDERLARQNPSALVHNDVMQTHTPDTQRSDQDPQYAVGSSIPNTLRSDGTAYITSIDDEWWNMPFTSYGDFLGLDPVNLFRQGDDPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Z0</accession>
    <name>A0A7D5V3Z0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">brr2</name>
        <name evidence="13" type="ORF">G6M90_00g099120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546436.1">
        <property type="nucleotide sequence ID" value="XM_014690950.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240859"/>
    <dbReference type="KEGG" id="mbrn:26240859"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="536"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="755"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1387"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI73838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2206" mass="249696" checksum="4E65A34ED01D1AFA" modified="2021-02-10" version="1">MSDPHRDVSQYKYSAMSNLVLQADRRFVTRRTDEATGDPESLAGRLSIKDMGARVARDEAPKQKKQSGMPAIERGSLQEGEDVLLREQRRRKTEAQQQRGTGVLGANDALIEGITYRPRTQATRATFDLILTLVAKNLGDVPQEVVRSAADAVLEYLKDDDLKDLDKKKEIDDIIGSTMNPKQFNELVNLGKKITDYDAQDDDEDVNAGDANGEDAEIDERQGVAVAFDEDEDEDEIINEVRDESSEDEEGEDEDDENGETSGPKPVEDLDDDEMVLDSGPGGSKRKGDEKSSIPARDIDAFWLQRQIGTLYPDAHEQSNKTKDALRILSGEPDEPEGEEKSLREIENDLMELFDFEHHELVQKLVENREKVFWLTKLARADSAEDRENVEREMGSEGLQSILDELRGKSAAGDDKKRKVDIKMDIDVPASFNAEAPKQERPEGQLVGGLQPKKVVNLDNLVFDQGNHLMTNAKVRLPEGSTKRSFKGYEEIHVPPPKKRNEPGDVLIPITDMPEWSRLPFSTAKSLNKIQSKCYPSAFQDDGNMLVCAPTGSGKTNVAMLTILREIGKNRNAETGAIDLDAFKIVYIAPLKALVQEQVGNFGKRLEPYGIRVSELTGDRQLTKQQIAETQIIVTTPEKWDVITRKSNDLTYTNLVRLVIIDEIHLLHDDRGPVLESIVARTIRKTEQTGEPVRIVGLSATLPNYKDVASFLRCDIKKDLFHFDSTFRPCPLRQEFIGVTDRKAIKQLKTMNDVTYNKVMEHVGSNRNQMIIFVHSRKETAKTAKYIRDKALELDTINQILRHDAGSREVLNEAASQATDADLKDILPYGFGIHHAGMNRVDRADVEDLFASGAIQVLVSTATLAWGVNLPAHTVVIKGTQVYSPEKGSWVELSPQDVLQMLGRAGRPQFDTYGEGIIITTQTEIQYYLSLLNQQLPIESQFVSKLVDNLNAEIVLGNVRTRDEGVEWLGYTYLFVRMLRSPGLYQVGAEYEDDDVLEQKRVDLIHSASLMLRKSNLIKYDEKSGKLQSTELGRIASHYYITSTSMDTYNNLIQPSITTIELFRVFALSAEFKYIPVRQDEKLELAKLMVRVPVPVKESIEEPHAKINVLLQAYISRLKLDGLALMADMVYVTQSAGRILRAVFEIALRKGWASVAKTALDLCKMAEKRMWPTMSPLRQFPTCSKDIIQKAERIDVSWSSYFDLDPPRMGELLGMPKAGRAVCGFVAKFPRVDVQAQVQPMTRSMLRVELSVTPNFEWDDSLHGAAESFWIIVEDCDGEDILFQDTFLLRKDYAESESNEHIVDFTVPITDPMPPNYFVSVISDRWMHSETRLAVPFHKLILPEKFPPHTELLELQPLPVSALKVSGYVDLYPDWKQFNRIQTQTFNSLYKTDQNVLIGAPTGSGKTVCAEFAILRHWTQGSAGRAVYVAPFQEVVDARLQDWQKRLAHLNGGKEIVKLTGETATDLKILERGDLILATPTQWDVLSRQWKRRKNVQTIELFIADDIHLLGGYMGYVYEIIVSRMHYIRTQTELPMRIIALSVSLANARDMGEWIDAKKHDIYNFSPHVRPVPLELHVQSYSNPHFPSLMLAMAKPAYLAITQMSPDKPAMIFVSSRKQTRQTARDLLAACVADDDEDRFLHAEVEQMRPLLDRVHEEALAEALSHGIGYYHEALSQSDKRIVKHLYDNGAIQVLVASRDTCWELTSTAHLVIVMGTQYFEGREHRYVDYPLSEVLQMFGKSLKPSKDGRGRGVLMVPSVKREYYKKFLNEALPVESHLHNYLHDAFVTEISTKMIESGDDAINWTTFTYFYRRLLANPSYYSLTSTTHDGLSNYMSDLVETTLRELSESKIIDFDDEDGSVSPQNAAMIGAYYNISYITMQTFLLSLSARTKLKGILEIVTSATEFESIQVRRHEESLLRRIYDRVPVKMSQPVYDSPHFKAFVLLQAHFSRMQLPIDLAKDQETLLSRVLSLLSAMVDILSSDGHLNAMNAMEMSQMVVQAMWDRDSPLKQIPHFAQEVVKVSNDFGIKDIFDFMEAMNPDENPEYNNLVKRLGLSQKQLAEAAGFTNDKYPDLELEHEVLDQDEIQAGEPSYLNIKITRNVDEDDEVDPTVHAPFYPTKKMENWWLVVGDDKTRNLLAIKRVTIGRELNVKLEYTIPAAGEHGLKLFLMSDSYVGVDQEREFTVTAAEGMDVDGDEDDEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V444</accession>
    <name>A0A7D5V444_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC transporter aclQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">aclQ_1</name>
        <name evidence="14" type="ORF">G6M90_00g107770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544066.1">
        <property type="nucleotide sequence ID" value="XM_014688580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V444"/>
    <dbReference type="GeneID" id="26243453"/>
    <dbReference type="KEGG" id="mbrn:26243453"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="271"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="587"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI74410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="848" mass="93631" checksum="AA5A48CF9A3FF3E8" modified="2021-02-10" version="1">MARAELALQTLFYLYPVLLTLTLIGAQCLLFFRNRRREAARIANPSPSDHEPKRPERTRRICAWLIWSLQLVLSALLIASTSLAAKEALADHGEAPGTTAFPFSAYLASYVAVLLYFLAGLLPDPQGPWNPTAAHGSAWITGALMEVVVAAVLSSTQTSLAVSKTFIDALNALGVSRGAIFVLMAAVLIFRECQLRPSVPKSLPEERQSLLENGNGSSGNYATVPDSKPASDAAKTPQTANMSWLTYVASFRVLFPYLWPKDSVLYQAVVVVCVVLLICQRIVNVLAPLQLGNLVDALGKGGIPYKDIILFVAYRYLQGNQGAIGALRSVLWIPVSQSLFRRLSTAAFEHVLGLSLEFHLNKKVGEVTSALSRGAATNTFLEVFCFQVFPMIFDIFFAGVVFFVKYDAFYTVIVFFIMWSYIFLTLYLVKYRARQRRDMTTKTREMEAIRTDAIIAYETVQHNCAIPRETQRFKDHVLVFQRAERLVQWSLNGLNIVQSSIFTLGTALLVAVSAYKISIGEQTVGEFVSLINYFVQLQGPLNFFGTYYTMLQNNLIEAERLLDLFKETSGIVEKPDAVALPAARGEVAFKNVKFAYPVKKGEPVLDGISFTVAPGTKTALVGASGGGKSTCLKLLFRFYDVTGGAITVDGHDLRDLKTDSLRRNIGVVPQDTVLFNATIMYNLLYASPNATEADVHEACKAANIHDSILNFPDGYETKVGERGLKLSGGERQRIAIARAILKDAPILLLDEATASLDSNTEREIQDALDRVTSGRTTITIAHRLSTITNSDEIVVLDKGKVVERGTHEELLALRGKYHVMWEKQTTIETREKEKMEEQGEASEAGSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6Z5</accession>
    <name>A0A7D5V6Z5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">U4/U6 small nuclear ribonucleoprotein Prp31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Prpf31</name>
        <name evidence="11" type="ORF">G6M90_00g109280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543926.1">
        <property type="nucleotide sequence ID" value="XM_014688440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6Z5"/>
    <dbReference type="GeneID" id="26243313"/>
    <dbReference type="KEGG" id="mbrn:26243313"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="259"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="595" mass="63715" checksum="1F68FA121AFDD968" modified="2021-02-10" version="1">MSTVADELLNDFGSSGDEAEENDNDGLVNDEPQENGDHDVMDVDGDQEGSDDEEGNDMKEMGDAEATKAKVEKMQLGAVKDVRSVASLMQTLEPVLEKIEQYRSQTSTQTTNAGNIEDHPEYHLLTQSNSLSTMIDGEVVLVHKFIRDHYSTRFPELERLVTTPLEYAKVVSIIGNGPMSSESIKALQTSTDNPMKMGLKAVLDGPSLMVVTVEATTSKGHELNPEELNRVRQACAMMVSLHKAKQTLTEYVQSRMNIFAPNLTALIGSLTAAQLLNAAGGLTGLSKTPACNIPSWGSKKRQAGLATNIGVRQQGYLYNSDMIRGIPNDLRKQAMRIVAAKLVLAARVDRIHSTPDGSTGDQLKSQCLERLEKLTEPPAKKGQRALPVPGDKPSRKRGGRRARKAKEAVAMTDLRKAQNRMAFGKEEQEVGYGTGSGTVGMGMIGQQNDGRIRNVQIDQRTRAKLSAKNKGWGVASTVGGAASSIGGFGQTPGSIDLRAKGLRASGVGSTIGSATGTASSLAFTPVQGLELVDPKVQAELSKKRKAEEDRWFKGGTFTQVGGASSTNGGFKVPDLPAAKRVDTGATKMGPPPPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V7D2</accession>
    <name>A0A7D5V7D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">erp38</name>
        <name evidence="12" type="ORF">G6M90_00g107880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544056.1">
        <property type="nucleotide sequence ID" value="XM_014688570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V7D2"/>
    <dbReference type="GeneID" id="26243443"/>
    <dbReference type="KEGG" id="mbrn:26243443"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028988874" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="133"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="40484" checksum="CA8685E21DD57111" modified="2021-02-10" version="1">MVLIKSLVLAAVAAVATARSAVMDLTPANFDKVVLKSGKPTLVEFFAPWCGHCKSLAPVYEELAVAFEHAKDKVQIAKVDADAERELGKRFGIQGFPTLKYFDGKSDKPEEYKSGRDLESLTEFLTEKAGVKAKKKLEMPSEVVMLTDKSFAETVGSEKNVLVAFTAPWCGHCKNLAPTWESLAADFVGEANVVIGKVDAEAPNSKAVATEQGVTSYPTIKWFQAGSKTGESYDGARSEDDFIKFINEKAGTHRVVGGGVDRVAGTIAVLDALVAKFTGGAKLEDIVGEVKSAVEKFNDDAKYAYAKYYVRVFDKLSKSDNYVSKELSRLEGILEKGGLAPSKRDEIQSKTNVLRRFAEKAAEKAEELKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YN98</accession>
    <name>A0A7D5YN98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptobrevin YKT6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YKT6</name>
        <name evidence="11" type="ORF">G6M90_00g024530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548129.2">
        <property type="nucleotide sequence ID" value="XM_014692643.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YN98"/>
    <dbReference type="GeneID" id="26237573"/>
    <dbReference type="KEGG" id="mbrn:26237573"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="9">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="219" mass="24817" checksum="1CB40EC2166B1EF3" modified="2021-02-10" version="1">MKLSYIGIISYDTREGIDPKNREPSQELAVVKDVSSYGLLTRNNYAQFMTFFAKQLAEKAKPNQRQSVAQDAQDFVFHVYSHKLGVCGVAISDAQYPSLAAHKLLGNVVNEFLAKFPASSWKDLTASSPRANIKDQLAEYQKELQQQLAQYQDPAQIDTIGQIQRELDDTKQVLHQTIESVLGRQEKLDELVHKSNDLSDMSKGFYKQARNQNRCCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNQ9</accession>
    <name>A0A7D5YNQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g014960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549028.1">
        <property type="nucleotide sequence ID" value="XM_014693542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNQ9"/>
    <dbReference type="GeneID" id="26238472"/>
    <dbReference type="KEGG" id="mbrn:26238472"/>
    <dbReference type="OrthoDB" id="4939019at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="273" mass="30799" checksum="70E56FD4EBB06D0A" modified="2021-02-10" version="1">MPPPISDSDDTEASLSNEVSAPPLFDCLPLHVVSEICDNILGDIGYLQKLGHLPSYWKFRLTDNFGIRLEGLKSEEKAAGLAAEHRGKLWEHHEEDLRFLRDLIEAVFNRPRICHCAFTGVEDTLKDILHLAENSPTLYCHDLGEFFLKKAHQEYAKDIKTARNLLGELHGVSFWADKNVAEATFPNVMARLLGCNRQKFKPANVFDEIGAISPNILSDILIIRSCNELDSMDCYAELLDVTLAARRMKRKLDEIDRGLQRAIGCYLSTSDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNU0</accession>
    <name>A0A7D5YNU0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Major facilitator superfamily multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mdrA_0</name>
        <name evidence="11" type="ORF">G6M90_00g013910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI64182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014693645.1"/>
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    <dbReference type="GeneID" id="26238575"/>
    <dbReference type="KEGG" id="mbrn:26238575"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="83"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
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        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="570" mass="61651" checksum="8AB734E9DD20FD74" modified="2021-02-10" version="1">MAADSSSSSSATAADRDVEAQQAQRSRKHSHWSVLVDQAGVDDAVLNHKYPGQGTHESPYLVDFLPVDPRNPMTFSSPFKWTVMIVAAISTLAVSFTSSAYSGSVRSINEEFHASTEVTILGVSMFVLGFAIGPLFWAPFSELYGRQKLFFLTYMALTAFNAAAAGAPNMIALIVLRFMAGAWGSSPLTNSGGIIADLFTAKERGIATSIFAIAPFLGPALGPIAGGFLAEAEGWRWVEGLTAIFTGTLWIIQSLVAPETYSPVLLRKRAEELSKRTGKVYISKVDAAMPRKTLFGQIKVNLSRPWVLLFKEPIVFLTSIYMAIIYGTLYLCFAAFPIVFQSPYPQGWGWKPGVGGLSFVGIAIGMIASATGSILDNGRYARTAAKHGGVAPPEARLPPAVAGSVLLPVGLFWFSWTNGTNVHWVVPIIGSSIFAAGLVLVFLSLLNYLIDSYVIYAASVLAASAVLRSLFGCIFPLFTGKMYEHLGVHWASSIPAFLALACMPFPFLFYKYGEKIRLKCKYSAEASHILEKILAKQQPAQEDEGITECEEGGREKGNQDTKTAPTTEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPM1</accession>
    <name>A0A7D5YPM1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPM1"/>
    <dbReference type="GeneID" id="26239891"/>
    <dbReference type="KEGG" id="mbrn:26239891"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="396"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
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        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="341"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQN5</accession>
    <name>A0A7D5YQN5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g021680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692895.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26237825"/>
    <dbReference type="KEGG" id="mbrn:26237825"/>
    <dbReference type="OrthoDB" id="5225441at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="452" mass="48304" checksum="5DBAB1D143F94098" modified="2021-02-10" version="1">MSIFAHIKKSRQQAKEHNAKLVEQKKKESDQVPYKHVPTHAATDAFASAPPSWREADRSRIIEQNRRRSAMAASGHHMSMPGVPRVGSSLSRVSYPGEGVAATIRMPRPYSYAGISPFPGVLRDSREMVYTAPDMTYVHPGSLKGKEVPRVYDSQRISPASSKGDPSPVESSSDSTSSQDDLEMKPSNAARARAGDGAKAHRLHPSRARRISDVSANQYTLSNIGRGNTSNYTRDSRPPPSMRGFGSIPTVPVMPPMNIGVLPGTIAAHGYNGTSPSNTLTPTSRRSSSTSLPGLSGVSTRQTASASMAPAVSSAHKSEYPLNRLSISSFESGVPTPSSRMTVGQSAGAGIAMAYSSTSQASSNGRHSQDVDSMRQDTWQTQAFVPDHQHMDRSRPPSTLAHGDLVNVFPEQAGLEAAPSKGGKSKKLSKTGGGKLFKKNRWSSSKVSVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQP7</accession>
    <name>A0A7D5YQP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PHO8_0</name>
        <name evidence="14" type="ORF">G6M90_00g042090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547548.1">
        <property type="nucleotide sequence ID" value="XM_014692062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQP7"/>
    <dbReference type="GeneID" id="26240111"/>
    <dbReference type="KEGG" id="mbrn:26240111"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="563" mass="61650" checksum="81FF72711705622F" modified="2021-02-10" version="1">MESEQSPLLGNENQSHENGRRHHSRRDSKWSRLREIGIFVWALIATAAVIIIAITTQHDQQTSRPDPDSRPTKRNLVFMVSDGMGPASLSLTRSYRQYVESLPEHDTLVLDKHFWGSSRTRSSSSLVTDSAAGATAFSCGKKSYNGAISMLPDFQPCGSVLEAAKRAGYATGLVVTTDITDATPACFASHVLIRQMQDAIALQEVGHGPLGRSVDLMLGGGRCHFMPNSTAGSCRLDDIDVVALAQEKYGWSYADSRPAFDALHAGQNVNLPLLGLFASSDIPFELDRRNMNDVYPSLSEMAQTALRTLEKATDKSDKGFFLMIEGSRIDHAGHINDPAAQVREVLEYDKTFKAVLDFIDDTTTETILVATSDHETGGLATALQEPGHLPVYNWYPHVLANVSASCESLAKSLQSHVSNMPASISKQQLKSWINEKLVIPGLGVTDATDDELSLLADDPEASVNTFAAIISLRAHVGWSTHGHTAVDVNVYSSGGPETERIRGNVENTEIGHFLSHYLEVDVDEITQELQEKARISGDNRFHATQDPKKTGDWASDKYHTFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSB5</accession>
    <name>A0A7D5YSB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g047120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544833.1">
        <property type="nucleotide sequence ID" value="XM_014689347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSB5"/>
    <dbReference type="GeneID" id="26242174"/>
    <dbReference type="KEGG" id="mbrn:26242174"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24306:SF7">
        <property type="entry name" value="AHBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64241" checksum="5450A0F7A5FD7E1F" modified="2021-02-10" version="1">MSAHTHVVLNLVQVNPAIAGLATISILILSIIVLFGGSASKHRHGSISPPSMPAYWLPFFAHAFQFFFNQDGFLASLKKRYPEGIFSLSMLGKRHHVIHDPSIMINIWNRPRCSSGEKWTAARALTKSFGLRKQDQITYSNLAHETPDLFKHMLSEPGLSEFVNGIVDHVKDHIAEFVTFNPSAADQTDWERSAKVDVVRSSKGDEFVEADLMSLVRNFVAKTANPALFGTDFVENFPDFWDLLWLLDDGFLSLATGLPGWIPWPKMQRAKAARRRMIAKAREFEEAMDKYLDGEDPGIKWQDMDNASTFVKSRISLYRKHGLSVEARASCDVALAWTMNANANQLTSWLLFELYRDPVLLETVREEIAPFVQVAQPQNEFGSAVWIAPELEKLDMDGLINQCPHLKAAYVETMRVYTGVWIVKWLGEDVVVEPKGKNTESYFLEKGHMAHIAHEMHQFDPTYFPNPKEWHHDRFLKHTEDTGRPNLQVVEMGTLRPFGAGPTMCKGRAIALREMLFYAAMVLSFYDMVPPEGKSWEEPELSKRAVTKHPTKPIKVWIKRRNVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSL8</accession>
    <name>A0A7D5YSL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 16">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">spm1</name>
        <name evidence="19" type="ORF">G6M90_00g078250</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 16"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545283.1">
        <property type="nucleotide sequence ID" value="XM_014689797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSL8"/>
    <dbReference type="GeneID" id="26241316"/>
    <dbReference type="KEGG" id="mbrn:26241316"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000157">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="363"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI70180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="47257" checksum="02D304202D4BC9D8" modified="2021-02-10" version="1">MADLQGRKVFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLYDMDIPRPDTFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLARIGSPRAQEYVRNLPFMPKKSFPGLFPQANPDALDLLDKMLTFDPSSRISVEQALEHPYLHIWHDASDEPDCPTTFNFDFEVIDDVGEMRRVILDEVMRFRQLVRTVPGSNSMAGQGQPSAPAQIPMPQAGGQWTAEDPRPQEYVAHGNGLEQDLQAGLDASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YST8</accession>
    <name>A0A7D5YST8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/potassium-transporting ATPase subunit alpha-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATP1A1</name>
        <name evidence="12" type="ORF">G6M90_00g040880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547435.1">
        <property type="nucleotide sequence ID" value="XM_014691949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YST8"/>
    <dbReference type="GeneID" id="26239998"/>
    <dbReference type="KEGG" id="mbrn:26239998"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="932"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="995"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI68122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1103" mass="121845" checksum="F2BD19C225723557" modified="2021-02-10" version="1">MSSEKPEDSHVADRIRWRDEEQGHDRQRSRSRPGLRRASSTDSLAIRSVHGRTTVDPAVTLPIQYRTVSFQIEESKGKERAELIRASEVAAKDLSDLQWHTITATEVAERLVTSSTDGLSETQAKRRLEEYGKNAPSPPKTNRILTILGYFFKGFGGILLVGSILVFISWKPLGDPPQLANLALAIVLLAVFFLQAAFTMFQDWSTSRVMSSIKDMLPEQCHVTRDGQMVHMQAEDLVPGDLVTIKAGNKLPADLRFIEVSPDLKFDRSVLTGESRPISATVDHTDVNYLETHNIGLQGTHCIIGSALGIVVATGDRTVFGRIATLTNEPKTGMTTLEKEVLYFVLFICAIMFTMIAAVVIIWAAWLRRDHPDWINVPTLIVDCVSVAVAFIPEGLPIAITAGLTITANLMRKNKILCKSLKTVETLGSVSVICSDKTGTLTQGKMAVTDCSIGTNNLSMEQLHDSMHSGNVNEKPNAFQTFGQLAALGALCNGAEMDAAQADVPVAKRHVFGDATDTAILRFSESVAQGNVAYFRSCWQKVFELAFNSKSKFMIRCFTIARPEALDRTLTTQDASRFQGNDLLLTIKGAPDVLVERCSYYLAPSGEVLELTQGAKATFEHLKNMHSSQGKRCLFLARKIVKGGRLQDGGDYEKSVVEEAKTGLTLVGLVAIVDPLRPEIRDVVSTLRGAGIRISMVTGDFALTALAIAREAGVVTCVHVDGASHLERTTVDIGSASEDNEDMKTVGSRRGALVISGPELTTLTDHQWSLLTEYEEVVFARTTPEQKLRIVREYQKHNVVAMTGDGVNDAPSLKAADVGISMGSGSDIAMEAADMVLLDSFSSVVAAVQYGRVVFDNLKKVIAYLLPAGSFSEFWPVMTSVVFGLPQILSSFLMIIICCFTDCAAATVLSFEKPEADVLLRRPRNVKKDRLVNWQLIFHAYAIIGVTETLASFAMAFWYLQRQGIPFKDLWFSFGVLPASINPDYYAEKLNEASSIYFVNLVVMQWFNLMATRTRRLSIFQHPPLFNKKTQNLYLFPAIVFALAMAVLWLYIPSLQPIIQTADVPVAHWFLPFAFGLFIILIDEARRCWVRRWPNGLLGRMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTB5</accession>
    <name>A0A7D5YTB5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g076490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987161.1">
        <property type="nucleotide sequence ID" value="XM_066131057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTB5"/>
    <dbReference type="GeneID" id="26241487"/>
    <dbReference type="KEGG" id="mbrn:26241487"/>
    <dbReference type="OrthoDB" id="3946741at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028931522" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI71060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1272" mass="137770" checksum="051575FA3BB89A34" modified="2021-02-10" version="1">MSSARLLLLSLVSTALAAETFHRKSNLTVALADVVPACAEDCFISFLSANYGLARGEEIPSLEELCSTDGNTGFTVGEGAVQCIAAEQAVGGCSDKEADSPAMSKAYYMCRDEPGALTPTHGVITATLAVPPSGGGPISYPAPSKTKRPFTRMHPPTTLIIETHSPTFSPSWSPDTTFSTAVVSTTTEITGTSSSTAEPAAAASGDSITPVQKAGIAVGVIGFAAVAIGLLLLFRLYRARKKRGGHTPLASSPRRRDSWGYKFDKSRRESSSEPSWMANPVHPPNDSAQGPSAAAMTGAIAIGGQAGARTQQQPQAAMPKSPPPGAYNRSSWRPSLIGLALSPSHSKNTGQGTATPTRPVSKLLPAKPILSLDIPKKPPTPPPKHTPPPPGSSSRKQSATTPSREYTRIASHPPVLPKLQIPQGHDFLHIPKSTNKPRESTMTEFEEDGRESSTVFSLESQIWSAPSAAPSSAAAKCHAVDRHGNWMPSDSNLVQAAELEGTTPLSAYPKLATSMAVLPVGTNGRGEQPGQGTAKRPSHRRSSSAPMPPNPAQQSIRVVTEPLATLKDGRDNVIPRPLFSDMGGNPRNASATASARHSFGRSLTRPRATSGDSGITNISVSSDEEHELQPPRRMSQANLSPVTESPRSGNGKSPVSYPKIPGRENGLSGKERSAQPPRMPILYKSAHHRTASGGIGNSVAMLTVGSLAPNPNPNMPKDTKNATSTSATMAGPPPNAFKPIIPTTKVTTASPHQWASASRGPRPMQNPGLPRTGSPTMRIVEPSPEPDDDRAMLPSSARPRSVQSVQQPQPQRQQTQLQPSPFPASQQRSQQHRYKVNRILNPINIRYSLNYSLGLRTNLVRSHNYGHSSSSSSVCNKLLKLRLKLEQARYDKVSNGKLLFHTHLTSVNTKFTRSKKLSHINNMDMQRNLTFRFNQPLYNQPLYNQPLYNQPLYNGRTKNSPYPKSLLLKLGQKGELPNCNKNNHLNETLGHNSHRETTTHHKSKRNNNPQCNKPNGQTLPTGSPACPHILTPSAGPNTRAHSGYRRKPASATPARRGRRSRQSQTITSSLPCGLCGDNPYTRRHNRNSKPGSRSKPLHSNHSRTTNTNTLQFHPDPSQQQMYIHRPQQCAYPYPDPRQYPNQGPGHHYPPSYPRQQQQQPQPQGQPRQQFQQPPLDQYFLQQQQQQQQQPPQVSIVAKRLGRDRAVNMSISTDCTSSASGSNNRHRASGGPMYLSPEVVTPRGSSGDLPSTPTWLPRLTPTRRGADLYLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTK4</accession>
    <name>A0A7D5YTK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g053210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540447.1">
        <property type="nucleotide sequence ID" value="XM_014684961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTK4"/>
    <dbReference type="GeneID" id="26246809"/>
    <dbReference type="KEGG" id="mbrn:26246809"/>
    <dbReference type="OrthoDB" id="3515453at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028811847" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="195" mass="20816" checksum="914E639E451D3106" modified="2021-02-10" version="1">MKSTAVLGSLTLGGLAAGQTVQSKPFNLLVQSDSKELDGRALGTCHTGAAIESICLLSDAKAVFNLNTTEGAQPGPGGLSGVLAWTLPSQPPIPSSMSFYTDPSTNVALPLFYPGTNNVQYVGFDGDDLMNIVSYLDDTKSPPTGQDPRVLKSWYICTTYNVGYTYQTLTWVLGGENPQNPSCVKVDVKRKFVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTU2</accession>
    <name>A0A7D5YTU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g010690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985609.1">
        <property type="nucleotide sequence ID" value="XM_066129694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTU2"/>
    <dbReference type="GeneID" id="26238894"/>
    <dbReference type="KEGG" id="mbrn:26238894"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI63605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="783" mass="85794" checksum="F6D59439C2B840D5" modified="2021-02-10" version="1">MDGDSSGSNIPGHVPGPAVNPQAHAQAQAQAQTQIHANARGSGERSEGVSDLGSQGRPRKFVIQSTFGVPRERRSRKSRPCDACRRRKTACIITTEPPCAFCKSRGIVCQSTSTTDGPLLRQQSGSEGGSTNSSKPAGADHSFPDSGPGDSGGRDATDILASPNTIKSSPRPITSPSNVSVSAASDCSPRTGYEASSGSYLSYASPRGRLRLDADASAASMDIVQPTLNSPESSCISGAGSVHTLEDNPGRATYFLGRTAEQDPFVLDAFSYGILSETATVDANVVQLHRGGSDVDDLPLHFLFLSMGHPKHTNETREQASDAIETKVWPHADVLVALYFKHVHPVLPIVSKVRFLRRYAGNSKSIPGCLRGAVYALASVFWAEDPSTRRGDRFPLEQHEIVDQAHRALRREIENPNFFVLQACLLLIHVQPPSIDAMEAPSTFTLSAQATACAQLIGLHQDPGDWNLEIVEKKLRKKLWWAAFVTDCWAAVSHGNPPHIGETSYNTTMLDIDDLRCDEDVPEELQHLVDRSSWSFDVASGARFLETIKITRLLRGVIDSNFQVDTRTTDLHQRIASRNQLADIHDKLKDWPSLIPSCLVVSRNREPATSCYNCPLHLTFYATKVLLYRALMHPATKAAKTDPNSNLRQWFPFAIADFGWFTEFFISINPGDLRGFWGRHARSQLILCGNFLVYLFLMAAEREHIEAAHRMLETFRVKVNNIADTDHVPTRALIRATTIRTNSFFSQAAAVMRHGPEASITEPITICGVDGPIKGQQGTGQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUC8</accession>
    <name>A0A7D5YUC8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor sdnS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sdnS</name>
        <name evidence="5" type="ORF">G6M90_00g066080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540164.1">
        <property type="nucleotide sequence ID" value="XM_014684678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUC8"/>
    <dbReference type="GeneID" id="26246973"/>
    <dbReference type="KEGG" id="mbrn:26246973"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="670" mass="74548" checksum="331495D0BC8C39D3" modified="2021-02-10" version="1">MSDRQAKQAAKRMRLGTKSCAECRRRKVRCVFSPGNSVCQNCVLHSTACTAQQPRAQVDEAECDRATLRQRVNQLEGLVKSLAGSVHATAAVSEPLAQAKSTVAARGNAPAQDLPTTSNPSDAPLINLFRDALLISDADGRVQDDDGSNAALGARRPSLLTSLQPNIPDEATIRSVLAMTRKYWCTWPACYYGSEPHQTFQVNRDAEGEEYLVRVLSHPPLDTAFCKSLLWFVLCLQQLPADSFRLLFPQRCSKQDMLASYLAYCRIMLASVPQDNLDAVQCHILGFKLYINMGMPQKAWACTRSAISTATLLGLNRLDAAAKESHRIIWLLSWETERQLSLILGYPSAVQTTTKTPFGSLPMGLEAPVAYRILYALALVYGDVINRDQDGANPSYATTVNIDENVRALRSLFPVEWWSPCDASDSISDAYQRESAKFLYFLLVKLVHLPYMLKSVYDARYEHSRQSVLEAAREQIRCYVRLRNFPGAEILICELMDFQAFHAGMVLIIGALYMPDNPGGTLHVFSEDGILIESLIASLRQMATLLECRVAEQGARVLELLVDTQRPPEDVELLVPYFGKLRIRKPMPDNPQSIEAPSTCSGMSTDAGHMYDLAAPSARPVVELSTNVFMTGVPAQFKQGSELRQDWFGVSDVDACYDWQHSWMRMDLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUG5</accession>
    <name>A0A7D5YUG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g022780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548277.1">
        <property type="nucleotide sequence ID" value="XM_014692791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUG5"/>
    <dbReference type="GeneID" id="26237721"/>
    <dbReference type="KEGG" id="mbrn:26237721"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13818" checksum="99ED7A30D932D653" modified="2021-02-10" version="1">MSSKVEEPPPYGGAPPPVAPKPSYGGGPAPFPDDQQRGYQQPYYQQQQQQQQQPYYQPGPQMGYYNQQQGQYPPGQYGPPQGQFQPGYQPYQTYQPQQRQDKSSGIMTGLLAGLACCCCLDCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUX7</accession>
    <name>A0A7D5YUX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein LTO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LTO1</name>
        <name evidence="4" type="ORF">G6M90_00g077770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545328.1">
        <property type="nucleotide sequence ID" value="XM_014689842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUX7"/>
    <dbReference type="GeneID" id="26241361"/>
    <dbReference type="KEGG" id="mbrn:26241361"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="149" mass="16569" checksum="E3465A4F23372FA7" modified="2021-02-10" version="1">MPSTPDPFDDVLNLEDNFYQRGYSQGLADGEKAGRMEGRSFGMQQGFDKFLESGRLASRAIVWANRIPPRAKHSPEEGGGCSDTQEDKKACALPSLPNNARLEKNVRMVYSLVEPDTLSTENTDEAVQDFDDRVKRAQGKVKVVERMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV88</accession>
    <name>A0A7D5YV88_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g031150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539626.2">
        <property type="nucleotide sequence ID" value="XM_014684140.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV88"/>
    <dbReference type="GeneID" id="26247537"/>
    <dbReference type="KEGG" id="mbrn:26247537"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="130" mass="14269" checksum="C5FE1477BB75D870" modified="2021-02-10" version="1">MLASSGIRILLRHGENRTATSRLGEAAEMTPLTLARRCGTDDEIVGRLKYGVEREPMSAFAKGDDVPVGRYSISSMTCGICLGLTEIRARLANLRTRRIYTCTTYPDYNICKNCFATVVALHGAKTKHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV96</accession>
    <name>A0A7D5YV96_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g073080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545754.1">
        <property type="nucleotide sequence ID" value="XM_014690268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV96"/>
    <dbReference type="GeneID" id="26241787"/>
    <dbReference type="KEGG" id="mbrn:26241787"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="209" mass="22299" checksum="F25FB6ADC511CB7E" modified="2021-02-10" version="1">MSGLMFGVIPTGQQLITDPTSTPSPTSFLYTLPNTKSFSHVMVILLPNVQLPDNTAAAIYLATAKDVAMAAELGGTPNFKFLGGIGSGKESALFKINSNPSQNHSNAENDGIVIGVSIESAESVGQRLEQLSADKTANSSASNSNTAQMPTSLLAQRIIQNAYNSLAGYTQPIGPGGVEVVPLRAFDDWWRKFESRIRNDPNFLAKPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVD2</accession>
    <name>A0A7D5YVD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547310.1">
        <property type="nucleotide sequence ID" value="XM_014691824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVD2"/>
    <dbReference type="GeneID" id="26239873"/>
    <dbReference type="KEGG" id="mbrn:26239873"/>
    <dbReference type="OrthoDB" id="3439669at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="344" mass="36471" checksum="C924084F53112257" modified="2021-02-10" version="1">MALALPKLKDELLDGDDDWEDEDDNNVGDSGTSGANSSDEHDDEDSDADDGSESGSDSDSDSDSDTSDGDSVQILSGSPVAVNHQQAISVPGSPVNSNHGVQTRSIPRLSNNANSEYGVTLERDIMENSLPNIVDLTLEDDEDGYNDTQNEALTQYSSQTILDDGMKAEPISEDTGANITDTNENSNTQEESLFINGNSGNSTGEVTYNHCKSQSPEEEAIRAINAHIKDSQQHGSPPSSNSDSEGPIFASPTRYDEIVHQSSSTGARTVRSEISSSLFVGSGDPNSSRSPSSESSASKTSKRSYNGNGNNEGPDRESESRKRQRSEGPFAGGSGSSVEDCIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVZ3</accession>
    <name>A0A7D5YVZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">sod-2</name>
        <name evidence="16" type="ORF">G6M90_00g045410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986370.1">
        <property type="nucleotide sequence ID" value="XM_066130377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVZ3"/>
    <dbReference type="GeneID" id="90967700"/>
    <dbReference type="KEGG" id="mbrn:90967700"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="99"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI67404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="212" mass="23241" checksum="40DC408384F052BF" modified="2021-02-10" version="1">MSVGTYSLPKLPYAYNALEPSISAQIMELHHSKHHQTYVTNLNNALKTYATATSSNDIAGQIALQNAIKFNGGGHINHSLFWDNLTPASSAEASPQTAATLMAAITKTWSSFDEFKAAFTKALLGLQGSGWGWLVKDGGSLRIVTTKDQDPVVGGEVPIFGVDMWEHAYYLQYLNGKAAYIENIWKVINWKTAETRFNGGRDDVFKVLKAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX67</accession>
    <name>A0A7D5YX67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g111590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543706.1">
        <property type="nucleotide sequence ID" value="XM_014688220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX67"/>
    <dbReference type="GeneID" id="26243093"/>
    <dbReference type="KEGG" id="mbrn:26243093"/>
    <dbReference type="OrthoDB" id="9983919at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35585:SF1">
        <property type="entry name" value="HHE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21758" checksum="F0549D496F8674A0" modified="2021-02-10" version="1">MTTISQAIINDHRELEQYYNEVINNENDHNHQQRFGNQFIWELARHSVGEELVVYPALEKHLGAEGKEMAESDRKEHHSVKQMLKEFQELSASDSGYVKQLKKIWGSLSDHIKEEEERDLPALESKLKSSEDESKSMAQSFERTKLFVPSRSHPSAGEHPPFETAMGLLAAPIDKVADLFRQFPDKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY68</accession>
    <name>A0A7D5YY68_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g094480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987662.1">
        <property type="nucleotide sequence ID" value="XM_066131480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY68"/>
    <dbReference type="GeneID" id="26246426"/>
    <dbReference type="KEGG" id="mbrn:26246426"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028826494" description="feruloyl esterase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="327" mass="35610" checksum="9B1061ADC962C6D0" modified="2021-02-10" version="1">MANKVTMLFLAFLIININPVATLSVASNPYTGGDTSGCGKMHTAQVIGLPIYRGIQSSGVHRSYSVHLPSQYDKHHEYPTILGFHGSSSIGLFFQADTKLDEARFTRDKIMVYPNGLGGAWAGANYSQATVDQDLQFVWDLLADLRQNFCIDSSRIYATGLSSGGGFVDTIACNSTVGGEFAAMAPASGSFYTNNDANHHLCEPARVPMPILEFHGGADADVKYGGGQGEGGIEPAIPNWLGWWAARNKCDTPHHQEDLFDGDVHHLSWACGGQEGVVQHYKTDDQKHDWPSTEPNFSQLAAGDKPTHIQASAIIQDFFMRFTRPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYA9</accession>
    <name>A0A7D5YYA9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">OGG1</name>
        <name evidence="14" type="ORF">G6M90_00g103040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987692.1">
        <property type="nucleotide sequence ID" value="XM_066131609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYA9"/>
    <dbReference type="GeneID" id="26240467"/>
    <dbReference type="KEGG" id="mbrn:26240467"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="112"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI73562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="377" mass="42649" checksum="D7FAA9D1951D1A47" modified="2021-02-10" version="1">MAWLLTVYQRTCTLQGRILSLRQDPSHLHYRVTWPEYQDALPTPPSRRVTDELNQDDTEELVRRYFSLNLDLGALYDQWSKSDPNFQKKAPEFKGVRILSQDAWEALICFICSSNNNISRISQMVHKLCNHYGPLIGYIDGEPMHDFPTPESLTGKNVESHLRELGFGYRAKYIANTARVVALEKPSSWLESLRNPRHSGPRLSSSAGSSNPTYKGAHEALLSLTGVGPKVADCVCLMGLGWGESVPVDTHVWQIAQRDYKFGKSKAKTFNKAMYDAVGDHFRTIWGDYAGWAHSVLFTADLREFSNRTGKTQPVEEVEPVRVKSEIQEEVILSGPRKRRSAVDAKARSNTVVENVGERKSIETISLHKRRRTRGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYV8</accession>
    <name>A0A7D5YYV8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRPS-independent siderophore synthetase rfs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfs</name>
        <name evidence="4" type="ORF">G6M90_00g000970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542973.2">
        <property type="nucleotide sequence ID" value="XM_014687487.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26244346"/>
    <dbReference type="KEGG" id="mbrn:26244346"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007310">
        <property type="entry name" value="Aerobactin_biosyn_IucA/IucC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022770">
        <property type="entry name" value="IucA/IucC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037455">
        <property type="entry name" value="LucA/IucC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34384:SF5">
        <property type="entry name" value="L-2,3-DIAMINOPROPANOATE--CITRATE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06276">
        <property type="entry name" value="FhuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04183">
        <property type="entry name" value="IucA_IucC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC N-terminal" evidence="2">
        <location>
            <begin position="254"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal" evidence="3">
        <location>
            <begin position="384"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI64667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1491" mass="166891" checksum="28806971CA9F945A" modified="2021-02-10" version="1">MSASNYAARARGETTKRLLAQLVNEGLASLDFLDESHDSATRRPRITGQREGNADRWLTLSAVHGVITTGHLRPNDLELPVTLCSGNNEALQDDPGAIFEFISVWLDCSEAMTTSVVQELRNSAAMLEKWMEHGWQTPTLDLDSSFLDWERSVVAGHPTHPFHRTCIANRLLKPVGPEHLPGMLNPDISFVTVPRTSVRTAGPFEKLIESMMKHFGISVASSQGNTTVPCLTQHLPALLHHFPEAELIETVPNGAVAQAAMRTVSIPGFAYDVKFSLACLVTSALRVLPCWSADAAPKLTWLLKEISPPNLWIVGEVAAVTGNQQDMAEARYMTCILRENLESRAKENNEALILSSALMEKPMGGSRTYAEVLFDLHTTADKVRWFKSYVQHLLSLALDPLVRHRVGLEFHGQNSIVRICKRTRAIKGFAIRDLAGVKLHGASLVAQGFDVTGLEASSTDDSHQVWDRVHHALIQNNIGYMMYALELERDHDGWGIVRSALADTLDVENNALGRQIYQYFLRDTMLFKSFITMRLISSLDGRFKLVDTEVPNILCKTSPWLLQICLAGSNNRDLMQQNLLKSTSQYGQLPGASRRLNPYPAVLPVQFVQNVERFHEALAAALDNVVERWWKDVDANLPGRMPLEPRVEKLLRWIDEGSDKGFVRGYKGHQGNLRPDMLILAAEEHAVPQFRVCEINGRFPINFLHFAASAYGALAGLPWSIPLLKPATDYTKLRDSLFQLFDPSVPIHFVGQTSDFPKDSPLFGLVEHRTGMRPRLVKPSSLVLIPSGSEPTGFSLYCVWGADPAVTKRPLKLITVEGRVLEEVHQVGCQLYDFELFALDPDMVRHIAMRSVNDMRSVFIAHDKRILGILRQELDALVHKHGVLTLAQARILEQGIVPTILPGCERLRQLLDASYADPGIKDGYILKPFRLARGSGILLGRDMSVSEWCRILESMKTADLRSCTAQYVLQPLQKVRSVNWFWDEERMVCRSKMVGAYYSVHGRFVGLGSWRTATASENVISASNDPIRRRRIRVGTNYHKLAKENVMKRWVEQGIWNEEWKSRSVWRWKHEEPLDPEFESNKDEMVGIESRLFGPPPEERESPPRPPQGVQDLPMTEERRRIRERGREASRPYHQFVYQVSKERELILDEMNPPEAADFSYLNQWPPTLHQAALHGEAGRQRTPTEPNLEYSVSTPPDINTTAYERVKNTWVRRGIWNKKWGMLPGMSWKHEQPLEEMLREEMGDDPVPHEGGAVEDRHEPSEAPRRPLFGAYPDEQVASFSSPLFDDSTHQPVREDAAPNRIASPLPVAANGDHVLGQPDGPLQEACPGGDPAVLPNGETSQSSAASSSDRDRINNREAGRSILLSGGRRGEREGSIGGGLAPEIPRTALGPTRPSKVSKAHRRNMTSTRRRPDGSEENGVQTPIPVPDTASSPLVDSSVQPRRSRRLQEAKRKTDEDSSAGGSSTSSPKSAKPRGVVKRRSRTNRQRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ39</accession>
    <name>A0A7D5YZ39_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL35</name>
        <name evidence="5" type="ORF">G6M90_00g100240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546325.1">
        <property type="nucleotide sequence ID" value="XM_014690839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ39"/>
    <dbReference type="GeneID" id="26240748"/>
    <dbReference type="KEGG" id="mbrn:26240748"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="141" mass="16242" checksum="DA3F1FEEEB7D9034" modified="2021-02-10" version="1">MAEPNTLISPPTPQLLDNSSGKVKTVQLWDKSKDDLMKQLGELKTELGQLRIQKVASSGSKLNKIHDLRKSIARVLTVINAKQRSQLRLFYKNKKYAPLDLRVKQTRAIRRRLSPEDKARALEKTKKRNTHFPQRKFAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ85</accession>
    <name>A0A7D5YZ85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tcpG</name>
        <name evidence="7" type="ORF">G6M90_00g000320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543034.1">
        <property type="nucleotide sequence ID" value="XM_014687548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ85"/>
    <dbReference type="GeneID" id="26244407"/>
    <dbReference type="KEGG" id="mbrn:26244407"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF20">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 1 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="115"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="249" mass="28457" checksum="AE80166833739329" modified="2021-02-10" version="1">MGSQKDNSRHPDVPQDKLVLYVRKAIPAPTANSLKPLMILEALKIPYSIHLIKSLPDELWYHEINPYKQLPAMEDVDVFEAGNGEKRRLNVFDSTSMLIYLCEKYDKDGLYIGKTAIERAQVMNWLIAYAAGLGATGEWWLKLRNDPQLAPALQVIEAAIKREYDILEKRLSEPGQKWVALADRPTLADFAIQPLANPRVAKNAKIDFDNWPKTKAWSEAVDKLPYIEKAMFENNRLGMTEEEIRVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZE6</accession>
    <name>A0A7D5YZE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metal resistance protein YCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">YCF1</name>
        <name evidence="14" type="ORF">G6M90_00g048830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986203.1">
        <property type="nucleotide sequence ID" value="XM_066130449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZE6"/>
    <dbReference type="GeneID" id="26242335"/>
    <dbReference type="KEGG" id="mbrn:26242335"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="911"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="68"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="342"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="690"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1244" mass="136684" checksum="8E8346D60B9D43CC" modified="2021-02-10" version="1">MTFGYRNRLTENDLWELAESENTRAAAKTFQDSWSVELVGKRAPSIWKTLFHGFGRAYVQAILFKVWADIFSLMQPQLLHFLISFVQSRGNLTNGVTLALAMFLVSVVQSLCLHQCFQRLSYTGVKVKAALISTIYVKSLRLSNGARASKSTGGIVNLMAVDSQRLQDCIQFSQHTWSAPLQIVLSVHAGRSSLVLVMIPINKTTTVAIKALQKQQMKNKDARSKIITEVVQMMKSIKLLAWGPAFMDKISHIRNDKELATLCRVGKLQALSGFIGAAAPFILACAAFSAYVLVQASPLTTDVVFPAFALFHLLTPPLAILPTAISSVTEASVAVTRLSAFITADEVQENAAVHNGTDTQQTNPAIEEVNFTARAGELCCVVGRIGSGKSALIHAILGSLHKVKGTVAVHGSVAYMTQDTWLLNATIRDDITFGHEWDAGFYENTVKACELVSDFVQFPNGDLTEVGDRAAVDQHVARHLVDNVIGRHDLLQGRTRIVVTNSEAALAESDAVVLLQSGRIAERGTGTQTMEAMRDFNDVEGKFGTLHDEDKVNMSADVSSTGKLQVISNIQGLTTMRQVASQEADPSTAHRADDERRRGLPRRRIDVESEPIIRTERSKQGLVGWKVYGDYAKSNGLVFVCLYVVALIGSQAAEIAEYRGYSVKCRYCWIVLLHKPDIRRDALSSVADNQTWSNIWLKHWSETNNDIGENPQVAKFIGVYVAFGRGSAVLVFVQSMILWLACSIKASRTLHERMVFAVFRSPMSFFEQTPAGQILSRFTRTWKPRPDIYRIDESLARQFNALFVSAARGFFILGVIALGSPLFVVFIIPLVLLYTYMQRYYLGAKRELKRLDSTSRSPVFAHFQETLGGVATICAYGAQERFIRENERRVDANMNAYIPSIKANRWLGFRLEFVGSVVILLAAGFAVAGVAFRSGQSEGMAGLTISYALQITQCLGSLVRATGEVETNIVSVERVLEFPGLPSEAPDVLESHRPPGSWPAQGAVKFVNYSTRYRPELDPVLRNINLDKRAKEKIGIVGRTGAGKSSLVLSLFRIVEPALGSVHIDDLNASSVGLLGLRRRVSIIPQDSALFEGTIRDDLDPDKAHDDTELWVALELAQLKGHVAGMCGDLDAKVYEGGSNLSQSQKQLISLARALLKPSTILVLDEATAAVDVGTDMIIQKTLRDNESGHRTIITVAHRIHTVIDSDRVVVLDDGEIIEADTPAALIEQKGAFYQLGREAGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z053</accession>
    <name>A0A7D5Z053_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-linked oxidoreductase chyH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">chyH</name>
        <name evidence="8" type="ORF">G6M90_00g017470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985896.1">
        <property type="nucleotide sequence ID" value="XM_066129799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z053"/>
    <dbReference type="GeneID" id="26238227"/>
    <dbReference type="KEGG" id="mbrn:26238227"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF9">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028810203" evidence="6">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="73"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="54906" checksum="E786D734996B581D" modified="2021-02-10" version="1">MTKFKMEVVAAVAAWALTSACTGLPAVRDLVPGLCPRDIDEAQALQSSLSPGAKVYFPGSPEFDDASTRWSTLSPPTVNVVVVAATAKDVSETVKYANRKKLPFLAYNSAHGAITTLGRMKSGVEIYLDQLNTIEVAEDGQTATIGGGALSKHVTDTLWDAGKQTVTGTCECVSLMGPALGGGHGWLQGHHGLVADQFVSMDVVLADGELQTVDPESDLWWALNGAGHNFGIVTSVTTKVYDIEHRDWAIETIVFSGDKVGAVYDAANKHLLQNGTQAADVINWSYWLHDAAADPNNPIILFYIIQEGVKAVDARYTQPFHDLGPVAVTPMSGTYKDLAGWTGIALSSPPCQKAGLANPRFPIYLQSYNVEAQEEAYEAFADATRGSSAFNGSLFMFEGYPVQGVQAVDGESSAFAFREAHLLAAPLITYKPDGADLDKEAGRLGNRLRDILHKKSGLCNVRAYVNYAFGNENPKVWYGSAKWRQERLKELKKQYDPLGKFSFFGPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z126</accession>
    <name>A0A7D5Z126_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dctn6</name>
        <name evidence="8" type="ORF">G6M90_00g036320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547024.1">
        <property type="nucleotide sequence ID" value="XM_014691538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z126"/>
    <dbReference type="GeneID" id="26239587"/>
    <dbReference type="KEGG" id="mbrn:26239587"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="194" mass="20840" checksum="92F4DEA7DD7525FE" modified="2021-02-10" version="1">MSSKRHSILPAIDRSGPKPPVNFSSSLTISENAILQGTHSITMQSETVVHPRSRFESNLGSILIGRRCIIHERAYIGARPADLDTAKPGGVALGDYVVVEVGTVIEAGDTEIGEGTTLQVGCKIGSGAKIGRHCTISQKSVIPPGEHLPDYTVVYSDGLRRLDSRGVTDMRKLGLVKQIAVLKKMIPSNPDKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z149</accession>
    <name>A0A7D5Z149_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548716.1">
        <property type="nucleotide sequence ID" value="XM_014693230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z149"/>
    <dbReference type="GeneID" id="26238160"/>
    <dbReference type="KEGG" id="mbrn:26238160"/>
    <dbReference type="OrthoDB" id="4940292at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1009" mass="114538" checksum="1E840962E824AD0F" modified="2021-02-10" version="1">MDDYNNAAQNTDMGRRQPSNMTNTVTRAPQRRRPNTAYDGHDYGQQQHTVNANHDGYPSVVNNQALGRDVETHFSSVSWPPNSGPALGLQPSAPQCYNQMNEPPLYHAMKLPYEAPSYQTMLNHSGRVSRQSLSQNPSSSQEFAPQLLPLPVYSQHQYIPPGYHQPSEGYDINEANGATAVDAARPSQQACRQGRVKTSRPTASHDVADSNTEYAATDHENDKDSNDAPDIRKQKRCQKKYEDQKPERDPKTGRFSQVCNRRKQKKEGRPDTKPEEVYENFENFRLRKGINLKAKNIPKGESNEGFEYNKYGQLNRKTFSTEDIREIVEFKIEESQESKVPPKDSQEPPKKDFTMWIQSAPCQTGDRLDLDWDQNCRWEDCPGKNRTVRPGQFRVAFDELPNFTGKGLVDPLKPALVLHLRCFEEVFSREETQKYLTDGVLKGDRREFESEDRNIVRLDKDGKDHSRTIIEEWRKATYKAQEAIAQKMVDAKREAGARNNNSGSGDCEFYQEPTYSAGHLASLTFALTAWYTDQNTKYRTMDGNGTRARKRNERNEERPKGIRATFDYSFGDIEYYKKAKEGQQNYRNKQPEEKKKAASKQPARKKQEDTKHRDSSDDPETKLLQAKERLEEAKKGLLQAKEQLEEAKERLDDAQQNYDEAEEKRDAQKHVPKKKATKKKGKRNNPAAQTAVEEASESLETAKRDCRRAPKERSSAKDTDAVEESPRSLQQSAKSHAPAHTDDLGERSGNEPAKENSEPSYNDAIYDPSSFWLCLTDANGVFEGESLYTLPGTAGQDQLADNKNLNCPGSLGANQGEWLENCHKPQESLPIGLTREDVLLWQEPMSTPTSYASMSSTQMLTAWASQGRVLEEVPDSDEDRPLRVKQEPSQQRVLEEAPDSDEDRPLRVKQEPSQQRGLQELPDYNNNSDPRTVPSRVAAPRKRGQRQISDYNDAEEAPSTKRARTAAPQQVSNTAAACHIPSYGPNRPTRNKRRADGDLDDSSHKRMCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1G7</accession>
    <name>A0A7D5Z1G7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g015970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548931.1">
        <property type="nucleotide sequence ID" value="XM_014693445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1G7"/>
    <dbReference type="GeneID" id="26238375"/>
    <dbReference type="KEGG" id="mbrn:26238375"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="68577" checksum="69123493CAB9A2FB" modified="2021-02-10" version="1">MEVPPAAISPEKTRGQEDDSLSKICEEMKTWLSGSPAVKCVESADEDTKIKSSKPATAVSSKASSSILVLPKAASDANAESESVTSADMRKLEAATILSNGPSNLPAETEKAMSQLGTRGLTAQDDCGTPVGEQHEKIKSIGSSKSTPHASTLLSDTPLPAPLHIIQAATAVEPGEDVKRRLSWSVSNVSPTEGGHEEGSSSLSSVVDQEADSHIVHLSSVPNAQEKIAHEYNGIILYDSTAEGSNCLIGAWLTKFRGLPSVTVPYENLCNESFVQCVIDTENGEFLAPIPQPETVRDMVDGPCEGYNDIGWRQVNMTSNLYISQEIKSRENTARTLRMTLEQLDHKPEPIVGTEEEHWPKAKCVIRPAAPQDFAQIAKIINAEAANTCNAQIFQDKLAMVDDVCKIFDACVAESRPFIVAIPAQDDFLDQSKWPRDSDEVYQEFAKYMAAKPKPAAPVAGFAFVSDYRMNLYGAPCLSSRYTGQVRLAVHPDHQRKLYGSALMDRLLLSISPFRRSTLDYVWECDDPKDVYQFPVTRNRRQYTQLYFEHFFSQEDSAAYQPGAEFLGKFGFQEIGYFKNAAVRFDDQHHNHWLNMVVWQTDNTPTSKIVARPQLSGSAAGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1R2</accession>
    <name>A0A7D5Z1R2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g005500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542196.1">
        <property type="nucleotide sequence ID" value="XM_014686710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1R2"/>
    <dbReference type="GeneID" id="26245227"/>
    <dbReference type="KEGG" id="mbrn:26245227"/>
    <dbReference type="OrthoDB" id="72726at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="25721" checksum="7855BBC188710989" modified="2021-02-10" version="1">MATLSKIRHVRVLGTEFYFFTGPSDRDGVSYALVQALKLLPGLQLDTFTVLSPGEDDYDYEVLDDLIEYGDGWKELRFICQVSSQLGYEFSDNVYRYKHSRNYPRKPQPAHWASVMNTRDGIQNQPSVTIYRSVRLGEPCSVMHEATRVIIEQMVLKEKEPVTFAERRYPPATPLKKKEEALEVMVVVKRGKAISGKISPINRGQKLSRDFFVGVVTALITAVIAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2F5</accession>
    <name>A0A7D5Z2F5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SER2</name>
        <name evidence="13" type="ORF">G6M90_00g061360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542732.1">
        <property type="nucleotide sequence ID" value="XM_014687246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2F5"/>
    <dbReference type="GeneID" id="26244681"/>
    <dbReference type="KEGG" id="mbrn:26244681"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="473" mass="51944" checksum="E3277A773742FB70" modified="2021-02-10" version="1">MAETARRKPSADRPQMDKMRRSSSYLSDHQQYRPPKKPETYHGIDEVVEGSSPPKPSSPKSVLPFRGVPQDDMPATIVESGVSHSLSHPNCAPPPGHKSDRLVATLFYKGASPSSAPASTRSAGLAESNETLPPNMAPTTNMDAFPLEPPTQEAEQLDHIYGSYISPLCIASFLHLMSTFPQPRGADEPHSSHRCLDNPDTPRIVELTLSPAPSPDCLSLSDLRKHEMIYRFEQEWNVDVVLQPDLVWRRHPRLVVFDMDSTLITQEVIELMAETIKEPADLAARVADITHRAMLGELEFDASFRERVALLKGVSATVFDDLRPVLDVTRGIPELIRALKRLGVKTAVLSGGFQPLTGWLAEKLGIDYAFANEVVVENGKLTGEAVGKIVGKERKRDLLVEIAAKENIHLSQAVAVGDGANDLLMLGKAGLGVAWNAKPRVQMEADARLNSESLLDLLYLFGFTAEEIQMLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z363</accession>
    <name>A0A7D5Z363_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SSCRP protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g046480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544774.1">
        <property type="nucleotide sequence ID" value="XM_014689288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z363"/>
    <dbReference type="GeneID" id="26242115"/>
    <dbReference type="KEGG" id="mbrn:26242115"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028822496" description="SSCRP protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31928" checksum="C10E64ED4978F552" modified="2021-02-10" version="1">MLALPAALLGAIAAVSVAATKEHLDGLPAYHYNAPIKVECMNRSSETGEHIEKNDEIQWIPFPVCNETGKPLEFHYGYEGELNCTLDFISDPFFHLLEFYIHSDAPMSCRLPARPPAHVEIVGEKPPAQEYVPLVFALAGTLQMSHMHISTHMNVLLHSMPKHHQRPHDSGVLDSAIAYSTSPLSHMEGTETARIIPGEPLPLTFSVRWFPTPALPKTEGRVEWRGLGGHIYATTVFYSIVSFGAGVVVAGMYTLGVVLPRRLKGRSMGGATPLGYGLSSGGVGNGWGYTKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z380</accession>
    <name>A0A7D5Z380_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin AMO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AMO1</name>
        <name evidence="8" type="ORF">G6M90_00g044410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547775.1">
        <property type="nucleotide sequence ID" value="XM_014692289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z380"/>
    <dbReference type="GeneID" id="26240338"/>
    <dbReference type="KEGG" id="mbrn:26240338"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099">
        <property type="entry name" value="RAD201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21099:SF2">
        <property type="entry name" value="SI:CH211-113E8.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="576" mass="60640" checksum="73F22C2C263FDE14" modified="2021-02-10" version="1">MAICKFYQQGYCKFGSTCRFEHPDAGNNRNQSQNRFGTLASGAGGGSRGALQDALDKYSIVTDTMVKDLTSEAPQWILSAYAPGRNAPEQLFGGYPREQSFEEMRLHFMMGKAAGNEQQALNQAQELYQNAQQQMQNAVRNIDEAARFVVEAESKHPNRLDVCREGSQGAPFGEFQVGKRPSGIAQPAQANPFSTDSTTTASPFGQAAAQPTPSAFGQPAALGQRPNPFGTPAFGQPAQPSSAFGQPSQPSSAFGQQSSQPAAPAFGQPSQPTSAFGQASTLGAKPSPFGTPSFGQSAQPTNSQPGGFGQPSQLGAKPNPFASGGAANQGSSPFGSLGTANNAQAPVAVNPFASSNADQINATPNPFASNNSNQNNTGQPSPFGQQQPTQNQSPFGQASRPNPFASTTTTANQQVNNPFAQSTQNQTNGVFGKPSPAPFGQGASQQPSSFGSASQPQQAVASATGGNNPYPPESTKQHPSLESYASRNMDGTLAAFKGKPVTYKDGKPGIRAFDGTWTRIWFPDGAPGYYKDTELSVEAFDEQSLAQWAAFAQTGQFAEGIMPELPPPRECTRWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3A5</accession>
    <name>A0A7D5Z3A5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ro-4</name>
        <name evidence="7" type="ORF">G6M90_00g078770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545231.1">
        <property type="nucleotide sequence ID" value="XM_014689745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3A5"/>
    <dbReference type="GeneID" id="26241264"/>
    <dbReference type="KEGG" id="mbrn:26241264"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="380" mass="42544" checksum="48D05EA5EB74B8CB" modified="2021-02-10" version="1">MTEILHNAPIVLDNGSGTIRAGFAGDDLPKCFFPSWVGRPKHLRVLAGALEGDVFIGQKAASELRGLLKIHYPLEHGIVTDWDDMERIWEYVYGEGLKTLSEEHPVLLTEPPLNPRSNRDTAAQILFETFNVPALHTSIQAVLSLYASGRTTGIVLDSGDGVSHAVPVYEGFAMPSSIRRIDVAGRDVTEHLQTLLRKSGYVFHTSAEKEVVRLIKESVSYVAHDPRKEERDWIGVKPNESKFAEYVLPDGHKLKIGQERFRAPEILFDPELIGLEYPGVHQIVVDAINRTDLDLRKSLYGNIVLSGGSTLTKGFGDRLLTELQRLAVKDMRIKIFAPPERKYSTWIGGSILAGLSTFRKMWVSVDDWHENPDIIHTKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3W0</accession>
    <name>A0A7D5Z3W0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g016200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548908.1">
        <property type="nucleotide sequence ID" value="XM_014693422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3W0"/>
    <dbReference type="GeneID" id="26238352"/>
    <dbReference type="KEGG" id="mbrn:26238352"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40628:SF1">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="466" mass="52924" checksum="398493A05EA8E329" modified="2021-02-10" version="1">MAEIDKEDPLPCPDWIVSTLSNVHIARDRRWFGDDYVTFPSHTCSLGQRSEVVGIGTVCLPVKASLTTKGPGSHGILRLCNVLHVPAGAVNIIGNVISDDFYLEVCAPTARVAAKLISRKKGKTAALLNSGPGQASHMYSVKLSGYPVGPRVGIPWVWSHEVMMEDMCSNWPLGEQERYLECEYRKERVSTAKPDSRSLGVEKSNTSKIDPTRETLVRHRERRQAASLYLAPEELDYVNNHWGDSASFMENLCLNEHMEKDCLRAKHLASTFADLYHEEDEYWEAREDHRKPPVVDRLFTPRQLYYMNRDHGNSSIFMTHMDLDVNNEDDCIEAQDLAEDLCFDSDDEDDEDADYLDENGLCEDEMEEYEPGMDGYELADPGIPARRSRDQVLGYLNVGTYEAGPRQLAEHFLSEEELNFVNQTYGDSMSFMTCFNLRFYKEVDCLEAKYIAAAEVRGRNKGEPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z414</accession>
    <name>A0A7D5Z414_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife protein DSP-PTPase phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g082560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543484.1">
        <property type="nucleotide sequence ID" value="XM_014687998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z414"/>
    <dbReference type="GeneID" id="26243661"/>
    <dbReference type="KEGG" id="mbrn:26243661"/>
    <dbReference type="OrthoDB" id="4934404at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife protein DSP-PTPase phosphatase" evidence="2">
        <location>
            <begin position="43"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="167" mass="19027" checksum="DF3EC5E1ED269EA6" modified="2021-02-10" version="1">MADEAGFYRFEQVKLHLLPTDRLFRSSAPHYKSRDTDQRLDPESIAFLHKQNIKHVIGVNWPADDATITETLRTAGIAYTPLKVEDHHAPTPEQLKKGNTEWEKHRNGTLVWCGFGHGRTGTMVSGLQIMAEKKKPHPHKFTHDDYVKNHVETPGQEAVLNTLQAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4D1</accession>
    <name>A0A7D5Z4D1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DAD2</name>
        <name evidence="19" type="ORF">G6M90_00g033570</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543284.2">
        <property type="nucleotide sequence ID" value="XM_014687798.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4D1"/>
    <dbReference type="GeneID" id="26244085"/>
    <dbReference type="KEGG" id="mbrn:26244085"/>
    <dbReference type="OrthoDB" id="3230169at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013963">
        <property type="entry name" value="DASH_Dad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28036:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08654">
        <property type="entry name" value="DASH_Dad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI68486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="148" mass="15649" checksum="3F4375CB58E78E3B" modified="2021-02-10" version="1">MSYPTRSLSSHMRAPSSSTSSASPSPALLARIEEKKAELQSLRELRDLSAAVSNQMEALEQKLTTLSDGTEAVAAVMGNWHNVLRAINMASTKLAKPSNDTTMEDASASNESLPQTLVRIPTEHAPTLQAQADAIEAAAVEGDSTANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4L2</accession>
    <name>A0A7D5Z4L2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g066340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986645.1">
        <property type="nucleotide sequence ID" value="XM_066130820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4L2"/>
    <dbReference type="GeneID" id="90967869"/>
    <dbReference type="KEGG" id="mbrn:90967869"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="63" mass="7326" checksum="AF74B53B48FBFD0D" modified="2021-02-10" version="1">MVLKRLQADGLYFRFAFDEYGVLQNIAPGDWEKQVCLFANEYLRQHDISQHLDEAAAVLKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4N0</accession>
    <name>A0A7D5Z4N0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor vrtR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vrtR2</name>
        <name evidence="6" type="ORF">G6M90_00g056770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544266.1">
        <property type="nucleotide sequence ID" value="XM_014688780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4N0"/>
    <dbReference type="GeneID" id="26242678"/>
    <dbReference type="KEGG" id="mbrn:26242678"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="821" mass="91981" checksum="6A82B6B4DC01E4D6" modified="2021-02-10" version="1">MAERRSQQKDRAVPQLSCALCRDRKLKCDKLDPCTNCTSSGVVCVPVYRPRLPRGRHARRARNNASPTAATGPPITPPCRHTSTGEHGTKELFAPGKGSDRGDRGVLGFRIDRLESLVQRGNCCNSNVDLENDGLRKLLLRRSIEDSDDAQLAATSLPSPTSWKPELSVGSDHDDGLCVQEASGLWANFIHRDRGIERAELPLFDEGTNQEIEMDEQRQDEHAKKAMFCLSLLGLNNPRITSATMFARDKEAIGNMCRVYLQNVDPIIKVLHRPSLSRWMLEGDRYLGYPEEHTSVMALESAVCYAAANTLTDSQCKAMFRMSKASIVSMHRKFCENAIERAGLLTTRDRIVLQAFVLYLIGRRSEEKGAAVWTLVALAVRLTMAMGLNREPNELAQSTESFFHRQMRLRLWLTICLLDLQASFAQSTKPLISHVDAEAAMSEVRHINDDDFEPYTMNEVTDREELTDTTFALVTYRAQVAGRLLNFAGSEPGIGTTSSCSTFCSAAFPSQEQRRHYVSQFQQQSLALVHFCDPESSPYAWFTWHSTQCLVSAMRLSELLPFQYTSSSQSLTTLPSPQPRADTDLLRRTLQNLEKTQLIYTDPRGEGFRWYITIPWLALSTAITECTSCADMALVRRAWPVIEASYLQYESFFIENNSETSRPPLALMMDQTREKLSTILQGTNLSRYIPCGNRARDAAAKLLTQVRSRKTSQSSSATPIDPVLNADEVLMNGSTFGSEASHTMSTQFFSQHNWDPTSVSLEYTSGMDGCMATPNLYHTISSSEVFEPSWLTGDVMGVYSNIDEDDDASMPTNKRENRDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4R9</accession>
    <name>A0A7D5Z4R9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isonitrile hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">inhA_3</name>
        <name evidence="2" type="ORF">G6M90_00g098290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546515.1">
        <property type="nucleotide sequence ID" value="XM_014691029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4R9"/>
    <dbReference type="GeneID" id="26240938"/>
    <dbReference type="KEGG" id="mbrn:26240938"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="56"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="232" mass="24811" checksum="8EBCDB066147C30D" modified="2021-02-10" version="1">MSSHIKIGVFIPNGAQFLDVACVDSFGVMSKKYLGVLPFIPSHVSSLAPDVSIYYVSSPKQGPEIPLTSGAVLKATHVYTDEEVAPGKLDMVVVPGPDPTEKFAEEGLKWLRGHAETEGVDVLSICTGLFICASAGIADGKRASGPRGLQNWLKESFPKLNLVGDKYRWVQDGNFWSSGGVTNGNELVAAYARASNRWAQPVVEAGLMMTEVGDRGQFYEGDGEGKDAVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6B1</accession>
    <name>A0A7D5Z6B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pyrG_1</name>
        <name evidence="12" type="ORF">G6M90_00g108040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987806.1">
        <property type="nucleotide sequence ID" value="XM_066131740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6B1"/>
    <dbReference type="GeneID" id="26243427"/>
    <dbReference type="KEGG" id="mbrn:26243427"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="276" mass="29716" checksum="A2ECD8D39E37A973" modified="2021-02-10" version="1">MASKSTVPYSSRAASHPHPVAKKLFRIADSKRSNLIISADFTDTESLLKCADELGPYIAVFKTHVDIIHDFSDKTVSGLKELAAKHDFLIFEDRKFVDIGTTVQKQYHGGALRISEWADIVNVSLLGGDGVVDALEQVISDETFPYRNERGLLLLAEMTTAGSLAVGEYTQRCVDVARRTGMGGAVIGFVAMRSLGPAGLDPSLADEDFVIFTTGVNGSKSGNVLGQRYQTPAAAVGGGSDFIIAGRGIYSAEDRVQAAKQYQEEGWAAYEARISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6H5</accession>
    <name>A0A7D5Z6H5_9HYPO</name>
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        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g047310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07876">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9393" checksum="8372E247ABA44555" modified="2021-02-10" version="1">MLGLRSKCLHPASKRPYIKSSMGGLDRSIEGCQHGSTHAFVVEFESEQDRDYYVNEDPAQASFVLEVLQKLDKATILDFSPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7V2</accession>
    <name>A0A7D5Z7V2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">G6M90_00g057410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
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            <taxon>Clavicipitaceae</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="QLI68849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="133" mass="14658" checksum="91D847600EFE2C56" modified="2021-02-10" version="1">MAEGKEWAALDNVGCHVSAMVALTHHSLIPRNLTAEGVLTAYEEEEHGEWTADVVGGAGEGRRDLLEQVDLSFEQVSVGNSSCRPGRDESVGLDTAYCNATLVRTPFKELRVQLHRTRCQNEVRSGDHWAKLL</sequence>
</entry>
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    <accession>A0A7D5Z867</accession>
    <name>A0A7D5Z867_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory protein LEU3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LEU3_0</name>
        <name evidence="7" type="ORF">G6M90_00g087450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Sordariomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542371.1">
        <property type="nucleotide sequence ID" value="XM_014686885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z867"/>
    <dbReference type="GeneID" id="26244885"/>
    <dbReference type="KEGG" id="mbrn:26244885"/>
    <dbReference type="OrthoDB" id="2341546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="577" mass="64008" checksum="4F73C10CA7580877" modified="2021-02-10" version="1">MTHWLTHHHHSKLEQLEQELKSIKQVVQPATNGAVQSAWTPPSPRAAIPALPEQKPASAAAINTTTPQTPTPQPESSIGQGHPGQSSERRLKTGPTEARILGNHIVSGEDIDWYFTKYLQHFHRFVPVLRKKDPDDCYEANQTLFWLVIYVACRRYARDRSLFPLLTDHLEKNIWTMSSVPALDFDAVHALLILCTWPMPNVRFVVDTSPTFAGIATTTALGLGCHTGQGKNSQFLVGLRQNFHATDEEASSTWLACCMLSQRTAAGIGIPPPYIQHSDSKTKAVLDASQWVDLIVMHDVQRFLNRFHTSMFTQVTAHGGVHESEVAMWETEFESLKPLITKYDSDISRFCLLAAQLEIQLCYFIWPPNTAVPSIKSHAVRVFNTARSIVAHSLDLETRIQFLTHSPQWAIRTNIDAACIIISILHSDCSPGMSEPDADLLVQQACGAILRASVRDADLAHRASIIMETFWSIRNLVPSFGAAPGARPDRASAGVTFWCLGKFRTALRDAQNSTDRVNKALEMMQGRCANSTPCTQPNSSQPQPGNLSSDPIQDVDWTMFMDDFGWAGDDAVLLGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8W0</accession>
    <name>A0A7D5Z8W0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g088830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542232.1">
        <property type="nucleotide sequence ID" value="XM_014686746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8W0"/>
    <dbReference type="GeneID" id="26244746"/>
    <dbReference type="KEGG" id="mbrn:26244746"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="406" mass="45538" checksum="E1C0ED080DDDE855" modified="2021-02-10" version="1">MDFDIEMGDAAPVTQDLPAEELPLADDILGTAEPQEPGELVEDESANPDENERKTLIPNKLHVRGVDTLHTDDIKAYIKSHFGPVDKIEWIDDGSANLVFANELTARDAIMALSAIEVVDVTVLPPGETLPAKPFDGKPEISLHVRFAVSSDKKQAGAALRSRYYLLHPEHDPEERRRRYKENRPRYRERDDDYRRNAGRRRRDSDDDVETFEASMYDDIPRSSRSRPDSAPEANSRSYAEENRGKELFMKKSTRRDRSASPRRDRDGDARMAEGEGSSHRNRSQARSIKNRIVADNSSKELFPTRASGRGGQLDQLEDSIGSARLEDQDLPKIVDISDAQSGNSINIRGLANQRVDDRAGFSIRGAATTSARELFPDKLGTSNAGKELLDPARSKRRQRAEDLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8Z1</accession>
    <name>A0A7D5Z8Z1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiol methyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g076220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545479.1">
        <property type="nucleotide sequence ID" value="XM_014689993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8Z1"/>
    <dbReference type="GeneID" id="26241512"/>
    <dbReference type="KEGG" id="mbrn:26241512"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30597" checksum="8B2A26A0D1697D5A" modified="2021-02-10" version="1">MATTADPPGRLSQSFQNLAFSAHGDQWSLMYKDGFHPWDRDGPSDALEELLLTRDDLVPRAHHQVLQGNLVRQTALVPGCGRGHDVLLLSKFGYDVVGLDVSPDALRMAEENRQKTEGTGRYEPQQGVEKGDIKWVSGDFFSESVLDGFGTNGSGTFDLIYDYTFLCALPPEARPKWAKRMTQLLRPSGRLVCLEFPSGKPLSERGPPWGVRPEMYEALLGAPGEEISYNADGSLVETTAAKPDANALHRSGLIRPAKTHPAGTNKDGTVSDFISVWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z979</accession>
    <name>A0A7D5Z979_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g055690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544163.1">
        <property type="nucleotide sequence ID" value="XM_014688677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z979"/>
    <dbReference type="GeneID" id="26242575"/>
    <dbReference type="KEGG" id="mbrn:26242575"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000020">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF247">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="357"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="486" mass="53777" checksum="BE70C92DCD533FDB" modified="2021-02-10" version="1">MTQSKSAKRKRKAQAQLPKKHVKTTTIVTPPPDSDATQFEPKNLQTVISDEELDITIETLTTLAQYPGLTKSKLCKNLRTAVYDFRQSCTTGVNSAEGANLTGRVTAALADEKYLEAKILLAEMRLRGEEPKLGALCRWVRDLDVVTQPKGASIVNPNRSDKERELLEVLDAVMRVSCPIDTNPEAKPPSQSSSHIALQPTWDLRPSTEPHQVYASVLDKSILSSGPDSPSSSLRIIETTPGHLRKPPNHHPAILYTTEPNTVDLSSEHSGITYHEHPSVPHLGLATGVLSPEECKAIIATGESVGFLPDIPVREGEDTSVLAHNFYWVVDAAFHDKLWARMAPFVPASLNGRRSRGVNRRFRVYRYVPGAEYRCHIDGAWPPSGIRPDDTYVYDDSPAEKKQSSLFTFLLYLNDEFEGGETTFYIPGQREGTLNAYPVRPVMGGVAVFPHGETKGALLHEGTSVRKGAKYIIRTDIEYDVEPSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z997</accession>
    <name>A0A7D5Z997_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g084120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543628.1">
        <property type="nucleotide sequence ID" value="XM_014688142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z997"/>
    <dbReference type="GeneID" id="26243805"/>
    <dbReference type="KEGG" id="mbrn:26243805"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="128" mass="13857" checksum="184B258C0B1CC0C9" modified="2021-02-10" version="1">MTASPALQRREGVPLVSIVSGWSRLPLRLCLTAATTLYKLHRNPNKKRNTTAKAMRNMHAPAYWPAVLGVKAEDQRGVLVEAKKTMVMDSMVMVMLDDGMGMAPAVEEGIAMDIDDDAASMLAIVACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9T9</accession>
    <name>A0A7D5Z9T9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g103350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546013.1">
        <property type="nucleotide sequence ID" value="XM_014690527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9T9"/>
    <dbReference type="GeneID" id="26240436"/>
    <dbReference type="KEGG" id="mbrn:26240436"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="224"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="281" mass="30876" checksum="F3916C868404DC55" modified="2021-02-10" version="1">MFRSRLLPRAGKSLGLGLRTTVNARRSLHQVPTLPHDYSQGVPNLMSPGGFAIAWSDYMTLMVEKLNALTAGTELEDKDTKTISLLTAREPNQAPIFNYASMAHNNHFFFQGISPTGTPMPDSLRAELEACFSSIETLRREFVITASAMFGPGFVWLVKAGINDYRLLPTYLAGSPYPGAHWRAQPTDMNTVGGDGSARSYFKNQVYGSRKRSGDLPPGGIELEPLLCLNTWEHAWLLDWGVGAGGNGGKTAYAEAWWNLIDWEKVAHKARSTRPAFKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAF9</accession>
    <name>A0A7D5ZAF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g083470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543568.1">
        <property type="nucleotide sequence ID" value="XM_014688082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAF9"/>
    <dbReference type="GeneID" id="26243745"/>
    <dbReference type="KEGG" id="mbrn:26243745"/>
    <dbReference type="OrthoDB" id="3539798at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028818884" description="AA1-like domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="6">
        <location>
            <begin position="56"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="182" mass="19582" checksum="722624432CFA234A" modified="2021-02-10" version="1">MHLPATTLITLALAGQALSRAADMVCTAASATTLLWRVTGFEYRDQRVAMGASRLEYGLANFTLQNSALAHKTTCTAVSTRSSPGFFAGDVAYDCAVRPDAKGDLSRFAFDRASGLLTINQTWACDRDGSRFGGQGQVRLSLKCSEREQSSTLHSGTNYSDRSVVCDKVNVPVNITYLQGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAH2</accession>
    <name>A0A7D5ZAH2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SAT3_2</name>
        <name evidence="6" type="ORF">G6M90_00g078180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545290.1">
        <property type="nucleotide sequence ID" value="XM_014689804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAH2"/>
    <dbReference type="GeneID" id="26241323"/>
    <dbReference type="KEGG" id="mbrn:26241323"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="31505" checksum="D1E552F33CA0F27C" modified="2021-02-10" version="1">MATRYDSQTLFRVDNLVAVITGGGSGLGRITAHALVANGAKRVYILGRRAASLETTKATSSRPENMTPIVCDVTSKEALRAAADKVRQDCGYCDVVFANSGVSTADASQYLNPRDKLDIKDLQEGLWQHATEHFTQSFHVNVTGVFYTTVAFLDLLDEGNRRGGVPQKSQVVVVTSLGGFARRPAASFAYGASKAGVGHMAKQLATVLAPYKIRVNSIAPGFYPSEMTANAGFMRDAEDPRREGSLAGSLVPLERVGSEEDMAGAILFLASRAGGYVDGNVLLTDGGRASIMPCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAP9</accession>
    <name>A0A7D5ZAP9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ABC multidrug transporter mdr1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mdr1_2</name>
        <name evidence="14" type="ORF">G6M90_00g113900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539693.1">
        <property type="nucleotide sequence ID" value="XM_014684207.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247524"/>
    <dbReference type="KEGG" id="mbrn:26247524"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000205">
        <property type="entry name" value="ABC transporter B family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="740"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="868"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="98"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="423"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="744"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1070"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="674"/>
            <end position="715"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="23"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="690"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI74487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1313" mass="143596" checksum="23AAEBD6236931AF" modified="2021-02-10" version="1">MRALQFLSGLRSSKSYSGGSKRPQNQANEAAKQPSTVENGQFRMEQDSKETSSSCNPYGHLPPHHAEMLERQAQVPTYRGSIFHLYRYASRHDILIMIVAAVCAMASGAALPIMTIIFGGLQGTFQDFFNNTVQPSRFRDEMTTYVLYFVYLGIGQFCVTFLSTVGFTYLGEHLTVKFRERYLQSCIRQNIAFFDNTGAGEITTHITADMSLIQDGISQKVGLTLAAIATFVSAFVIGFANSWKLTLMLCCTVVAWIITTTLTTRLMVKNTIKSLAAYSEGGSLVEEVLTFIHSTTAFGNQDHLAKQYDAHLAKAEHYGFRARTATGLMIAGLQIVMILGYALAFWQGSKQLIQGELPVSKLLTVLMSVLIGAFALGNAAPNVQAFTTAAAASRKVLATTDRVSPIDPMASSGISLDQVSGHISFQHIHHIYPSRPGAPVIADLSLDIPAKKTTAIVGASGSGKSTIIGLLERFYDPVQGTIRLDGHDIRSLNLKWFRAQMALVSQQPGLFGTTIFQNIRHGLIGTAFEHESQDSQRQRVIRAAKAAFAHDFIIALDKGYDTHIGQRGSILSGGQKQRIAIARAIISDPKILLLDEATSALDSVSEQAVKAALQVAATGRTTIIIAHRLSTIKHADNIVVMSEGRIVEQGTHEELLNKNAAYLELVQAQSVGSSVDEKQDSRVSPAGFEKQTSYKQETTAGSHDEIKSSRLSRDDLGGPTNRDSLYALLSFILSINKSQWSLMVIGCMLSVICGLGNPSSAVFFSKQISTLSQPIPPNEPGRIEKESDFWSTMYVMLAFVLGISFAAQNLAFAKSSERLVRRIRHAAFRAMLRQDMSFFDNKQNTTGYLTSFLATEAAHIAGLSGTTLGTLIVSITTLIAACSLSIAVGWKLSLVCIATLPILVGCGFLHVWLVAKFQRRARASYDESASYAAEAVSDMRTVAALGREMDVLEEYRTLVRTQLRQNILFILKPSALYAASQSFLFFCYALCFWWGGNLIARREYDMFQFFLCFMAVLFGAQNIGLIFAHAPEMGKAYASTQKLKKLLDQTPTIDPWSDAGDSVKDVAGSLEFQDVHFTYPGQQDQRLVLKGLNIKIHPGQYAAFVGTSGCGKSTAFKMISRFYDPQSGAVLFDGRDIRKLNIRQYRNQFGLVSQEPALYQGTIKDNISLGCPDGQVTDEAIESACREANIYDFIVSLPDGFNTLVGVRGGLLSGGQKQRVAIARAILRNPRVLLLDEATSALDSESETVVQAALDKASRGRTTIVIAHRLSTIRKADIIFVFDDGKVVEIGTHSQLIEKAGKYAELVSIQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBX3</accession>
    <name>A0A7D5ZBX3_9HYPO</name>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">G6M90_00g107240</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="29920" checksum="0315019F6D70EED9" modified="2021-02-10" version="1">MASIVPDVEQVTIKLRSEPGLKSASVDVSNDYGTPNVLFLYYTPFIPDDNKLDLDAIQDEFQSWNAWELGQAETQLIRHVEAGNLPSDDSIASRIIRNNYRSKAIDFFRQGNEAWLSLANNSTAQKVIVTAQSEAHGSIRQEMRALAAEQHLQSQFEVIINAISGSVEVAEENKFYFTHVYYRYDNNSRRFLPVISDTTFGIKKGDEGSQAGGDKVKLEINLSVNTYNFDRKFWRDHRHEGEEAIQMGEPIRKQMALDFYVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR16</accession>
    <name>A0A7D5UR16_9HYPO</name>
    <protein>
        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">G6M90_00g026750</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="235" mass="25182" checksum="257A442738691838" modified="2021-02-10" version="1">MSHLPSHTSSASARVPSIIRRKPIPTESETASNTSTRDNRGQYAAVSAEDGDDCTGSAKKVGSSQPRADNQFALWNGSHLASFGALLALTTLAVDPFPQASVSMKHCEHVTGHVASIPRTNSYTRNIALTGTHANAPDAGMQLAIYWGVLEPPDNSSVSIPSTLDCLTDNCTFPAEQGASFTSLAMCAYAWDVSDYIDGEMVDERRDFSLGPGLFLWGHLNTTYVTRAQTEGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URD1</accession>
    <name>A0A7D5URD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g004550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985843.1">
        <property type="nucleotide sequence ID" value="XM_066129574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URD1"/>
    <dbReference type="GeneID" id="26245135"/>
    <dbReference type="KEGG" id="mbrn:26245135"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="380" mass="42689" checksum="CF750F0943FA9450" modified="2021-02-10" version="1">MAAIVGHGFKPWISRPDTNGVIGVCIALALITAIYKFIAKSWTATEPQANIDAKPGEMPARHDETPSLVVEPLEKFDWQATEPTIYLPIKPVYHITMALQQDTPSRLITIDRDYLDRVTLRRSLIDEKGHAVHGYLPRGKESVAELYTYLLRDYLPARYPTMFRIGPDGTVFENTVTGRTFPIQPPEDADAALRTLGETVEEDLFLLHETSGGHLCVAFMCCFPSGFDPSEKFGNLLKDIHAPVPSYSKIGTSMERFFSKLQVGKSVKRLNWSVQTNNELYTLGNHIKDDAAEVVSEDSIDVNQTYLRVELQTLTRLPRTQAVLFSFKTYLYGIRQIREQGSGPELADAIEGLKSGNAPGMWRYKSAVRWGKPVCDYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URH7</accession>
    <name>A0A7D5URH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g021280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548420.1">
        <property type="nucleotide sequence ID" value="XM_014692934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URH7"/>
    <dbReference type="GeneID" id="26237864"/>
    <dbReference type="KEGG" id="mbrn:26237864"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
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    </dbReference>
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            <begin position="55"/>
            <end position="74"/>
        </location>
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            <begin position="81"/>
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        </location>
    </feature>
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        <location>
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            <begin position="227"/>
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        </location>
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        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="311"/>
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            <begin position="311"/>
            <end position="320"/>
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            <begin position="343"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI64859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="368" mass="40146" checksum="350ED3B6E02424BF" modified="2021-02-10" version="1">MTAPSSGPGPGPGTASSSASSTTTCTTAAAGKYGHVPPGSCGSNYEYDPSFGGNMAFAVLFGLSTAVHLVQAIVLKKTFAWVLLMGGAWETAAFSIRTAGAHDLQQVQFRIWGQLLLLLAPLWINAFAYMTVARGVYLGLPGKKIWGIGATRLTVIFVWLDVVCFIVQGVGGSVLSGDSAAGVKSIGMRVYTAGIGLQLGFVAVFTGMTVSFYWEMRRVTGCRVGRMGWLIWTMLLVLGMIVTRIVFRLVEFGPGLNHYDPMLGKETWPFLLDAFPMLVALVALNVMHPGYVLRGPDGDFPRLTRAEKKVIRRQKKEEKRQRKVAKKGQSAGKYMNTENIVLEDTRRANSESEWPIQERQRVELVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US72</accession>
    <name>A0A7D5US72_9HYPO</name>
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            <fullName evidence="7">Choline transport protein</fullName>
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        </lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65476.1"/>
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        <property type="nucleotide sequence ID" value="XM_066129477.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="34"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="QLI65476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="506" mass="55516" checksum="F72E9D4584EECD05" modified="2021-02-10" version="1">MSDTDKLKGTTSLDLESSTTNEDRGTQIKKRFNFWTAVGIAWEGWTASIAQGLLGGGSVGLLWGWVFVSVGILCMGLALADMWPLAGGQYVWAAKLAPPQLARVLSWFTAWAALAGMWLGTLSCGIGVSLQIQSYAVISRGYVPETWHTFLMCVACCGLWIMINIWAVDMLHQINTWVLVIHVTGYFVLIGVLLGCSSNKHDAKFVFTDFQNHTGWDSNFVSWSVSLLAALYAFFSLDSASHFSEEIPRANVFVPRAMCLQVVGNSLMTFPFIIVVLFCIGDIDAVLQSPIGLMSPFTQIIVNSTNSIPAGIILNLISTLVAFVAGCDLTGAVARAIWSMARDKALPQFLAKLEPKRNVPVWGNLVLVLPSILVYMIYIWNTTAFYGIMAGVLVAFQLSYIIPIGLYIVYAAWKKDLIKGPFNLGRLSYPCHVAAFIFGCFMTIVMSFPVYQPVTAANMNYASILVGAVLILSLCSWFTWGNKHYQGPLENSVHAEDEDSVHVYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USK6</accession>
    <name>A0A7D5USK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA repair protein RAD5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RAD5B_0</name>
        <name evidence="6" type="ORF">G6M90_00g020570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986043.1">
        <property type="nucleotide sequence ID" value="XM_066129858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USK6"/>
    <dbReference type="GeneID" id="26237933"/>
    <dbReference type="KEGG" id="mbrn:26237933"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="423"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="834"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112508" checksum="97B4ECCBCDED2E12" modified="2021-02-10" version="1">MVIERSAVLEFKVISPNARILVKVAAQSDFHAVTTIQASIIGQAVYYEALRALNQITFPRVESARSTATEQMMIRQRHNVLLHADTVSSVDIVNINSSESLTPSKRLVVRYQNKLHNLLLRRDVPPRFVNAEKMDLSLKRAFPFETEKQGPLNKSSRQPTLSGETLNLEAGLDTCFGSIIDIEAQLCSKEFLSSCDQAFKDPGYPILVVQTGNYFTLEHNGQKLARLSKGLCRTLHQAVTGRQASIRAFIRENWDGDQTSTILPIEINIYGIRANSEDIGRILSKSGIFLQLPRYSLKSVEYHNPHILQIEGYVEQDRVEAVLPSATPAADPANLRTESESVVNDSTTMINHILDSLSHPVLLRQLPADCRIRSTLLPHQREAIDFILQRETSSLPSEMSLWKYNNLDGDKPFYQHIFSGAKRPQQEETKGGIVADEMGLGKSLVMLSTVAGSLGRAEDFFSSQIQLFSNKSAKKAPSKATLIVAPSSLLIDNWIHEIRKHTYSGGLTFYKYLGLGRHTETDFLHKRAIVFTTYATLATDFCGGKNALADINWFRIVLDEAHNIRNRSTKQFQAVASLSSHHHWCLTGTPIQNKLDDLGALVSFVQVPILKNPASFQKFIINPIVSGSGTRYENLRVLLRSICIRRTRELLNLPDPVSEIRRVKFTAAEYSEYNKILLQCRTDLDMMVSGRLKGASNKFLLDTLMKLRLYCNNGSTNPILQSGSTGLPADPDEALTYLQQQEENVCSYCNGIIFYISETAETDGGRFISSCCHLVCGNCEPGHRASKERCPACASEGGNKLTLLNTSSSTGRQIQSHAGPENNSFDRPESYPSKLRELLSDIRRFSTEKSIVFSCWKKTLSLVSQLLHTHGIKYNMIYGSLSLNKRIEVLNDFRSPSGANILLMTLGTGAVGLNLAVASRIYLLEPQWNPYIESQAIGRALRLGQTARVTIVRYVVIDTIEESNILGRQRKKLQLVDGGFGKDKDMVSERLRPLLNMVETHRGDQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT27</accession>
    <name>A0A7D5UT27_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g019720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986046.1">
        <property type="nucleotide sequence ID" value="XM_066129840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT27"/>
    <dbReference type="GeneID" id="90967482"/>
    <dbReference type="KEGG" id="mbrn:90967482"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="238" mass="27016" checksum="DC12E1E42F8496FE" modified="2021-02-10" version="1">MRVNQATGISTNKVLLVPYEAHHVGKYHEWMGDPAIREATASELLTLEEEYENQQSWRTAHEKLTFIICEALPTADRASPSIKAKVVDADDRMIGDINFFIYQNDDPEETSPNRKANAALRGEIDVMIANTKHRRQGFGSASVQALLMYLRENMKHILKEYACSLKLGQVDLAELMVKIQEGNIGSRRLFENMGFKQAGGVNYFGEVTLLVSWAKVEKLVDEWLSSGEVYREVRYEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTF2</accession>
    <name>A0A7D5UTF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g024210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548159.1">
        <property type="nucleotide sequence ID" value="XM_014692673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTF2"/>
    <dbReference type="GeneID" id="26237603"/>
    <dbReference type="KEGG" id="mbrn:26237603"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39260" checksum="04497120E2A90F04" modified="2021-02-10" version="1">MASTDEPQSLRTAFEEAESKRRLLESSPDATSPTYASDLNSVLALYARVLDKISSVSLFSPNEGLEDMATSSLPYILVNFTIAELVQRTPFTVPARRKLVLRAARDAYERFLSLADGYGLVSGPYAKLLERYRDDEEQFAVVSKTGDMASKRDAKIASFKAEKGLREKLALLRSDGRYVEKDEEAAREVYLADVAWKIHQTFQGLEGLNREAEMLAMAPDPDPETSARHAREEADDASVRLDQPFGRSGRAGGPLLSREGRPLQPFTLVGSRADLARGVFRPGHNLPTMSIDEYLAEEKRRGNILEGGTDPPRMEVDEDDMDAVDRETYKAREWDDFKDDNRRGAGNTLNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTX2</accession>
    <name>A0A7D5UTX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g026540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547933.1">
        <property type="nucleotide sequence ID" value="XM_014692447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTX2"/>
    <dbReference type="GeneID" id="26237377"/>
    <dbReference type="KEGG" id="mbrn:26237377"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="2">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="178" mass="20283" checksum="02E2196AC9DABD12" modified="2021-02-10" version="1">MQDDRLPLCRVAFEGERTAHWALFIPEEIGSHEGTLVHIGVEKAASCGSNRTSKSTGKVEKYVLRCHEFRMMGSGAQSCFPIANAYSTESELRRAAEEVFKRKSYNLLTNNCQHFCIDVVTYWHKICPQSVPRSAVEDVLARAQGVTNISYMLRRTQLNKERTKPENDRGDRPRFSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU33</accession>
    <name>A0A7D5UU33_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g033470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU33"/>
    <dbReference type="GeneID" id="26244076"/>
    <dbReference type="KEGG" id="mbrn:26244076"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="36"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="458" mass="51338" checksum="2E0F8FCC2E94502D" modified="2021-02-10" version="1">MEGSSKIKPAARVSGQKQDVWSIINEAAAASPKQPIVNMGQGFFGYNPPDFILNAAKDALDRVECNQYSPTKGRPRLKKAIADAYSPFWGRKIDPETEVTITTGANEGMLSAFMAFIEPGDEVIIFEPFFDQYISNIEMPGGKIVYVPMHPPETGATKTSSAADWTIDFAELEKAITPRTKMIVLNTPHNPVGKVYSRDELQKIGDLCVKNEIIILSDEVYDRLYYVPFTRMATLSPEIEKLTITVGSAGKNFYATGWRVGTFRSTLPFSPVSPFNSIFFRLSSLTFVLLSPLTGWLMGPANLIKYVSAAHTRICYSSVSPLQEACAVGFEQAESEGFWDKTITDMKSKMDRFNEIWAELDLPYSEPEGGYFVLVNMKKVQLPADYPFPEHVASRPRDFKLAWFLIQEVGVAAIPPTEFYTPANAHLAEDYVRFAVCKDDEVLEEAKRRLRGLKKYMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUI7</accession>
    <name>A0A7D5UUI7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g038000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547160.2">
        <property type="nucleotide sequence ID" value="XM_014691674.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUI7"/>
    <dbReference type="GeneID" id="26239723"/>
    <dbReference type="KEGG" id="mbrn:26239723"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="92"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="230"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="552" mass="60327" checksum="0CED648F70813231" modified="2021-02-10" version="1">MPYRLDTHVLTVDANVIHKVDTANPANLYSMWTVFSRCADSVEQGRRLENLSWRLWQREQLVENANKNTASSAAFTTTTIPPKNVPSETRLQEVPQLSGSVESLADDETVDFTSVSAPLEIRPRIRRLDSSTTRRDRRISSDDFEKMIVSIVKDKAPLSAPSQTSPLMASTKQKLLVPPAPPALTRSGSTTTESQSSEQISEVSHPSPFPPPEGLRVQALPFPEPAAAASSQDVLPEPSSSPAPKPVQPKKQPARFALGGSCSSSEHSQSIENIKATSAAVGKKPMFQIGGSSGEDSLRSSGHSALPNTRISNLTAQALQHSESAVDSDTEAEYVDESAIDDDDSSDWEDSTEDSGKSSVDDKFFQRVESKANLASRPSLITLMLAQNERARTLGNQSSQSTPAIHRTRATPNGPSLGVSPNDSDEAPLMMKGMRHSALKPISEIPRSSAQPITTHATHVNFPAAFSPRTTRRNMLATELTESLRLNLVWERQQKKLGSKALLKRRHTSQDVANLKQYPQKACMKASEDAEAHSWNQYFSKEALNGYHSKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUK4</accession>
    <name>A0A7D5UUK4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-independent regulatory protein pac2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pac2</name>
        <name evidence="2" type="ORF">G6M90_00g047360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544855.1">
        <property type="nucleotide sequence ID" value="XM_014689369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUK4"/>
    <dbReference type="GeneID" id="26242196"/>
    <dbReference type="KEGG" id="mbrn:26242196"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="422" mass="45763" checksum="62AB7F34CA290917" modified="2021-02-10" version="1">METYHGFVRTPGDAIKLFEACRLGLLPRVQRRLSEKERQSIRSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGGGFGSGRRGAGKTPDSGRGSDEDHDDGEPEGYRYKADGLMKQSFSIITSTGQHLHLISYYSRPQPGQPELPQPSSDPSLRGIAPPKGMYPESSMGETNQTPALTRAPMQQPYMIAPHHAHAHQQAYVHYAQQGYGWPPSPAATPPYAHYAPAPFPPGTHLHSLHPPHMTQVSSQLPIAYAASHYTHAPPPPHYDRPSLPPLPQSKPASIPAYQRGASPPRLQDSPGHRERLGSHGPLPALNSVTAPIPHPGMTPPTRNHSVSPPRSSHESGLPSGFPSGHRSSLSALLHPASDSSSSKPASNGSSSSSPRISNAALEKCGVSEDARALRMLDKKFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUP9</accession>
    <name>A0A7D5UUP9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">mRNA-capping enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Rngtt</name>
        <name evidence="5" type="ORF">G6M90_00g042080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547547.1">
        <property type="nucleotide sequence ID" value="XM_014692061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUP9"/>
    <dbReference type="GeneID" id="26240110"/>
    <dbReference type="KEGG" id="mbrn:26240110"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="535"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="632" mass="70346" checksum="93B5247C5443FC28" modified="2021-02-10" version="1">MAGAHEPPPTAGEYVDTGPYTTDPPLLRDHSQLKTYKTSRFEYPDIRVFFRPHPKAAELPRTPAPLPLVVCIPGLGGSVAQFYPLLNSLVDLASCLSVDFPGGGRSRYAVTSWDAYTPEALGELLELVIEDHRDNEHGQGIILIGHSMGTMLAAQLASKSASHQTSLSKYVVAVVAVCPTAGPPDQQRSSLLRRLLWMPGWIFSLWRAWDGIGGPYSPSVSRFVGKEADLELRVMQYRFNQQSRTPVWRRMAYGALPVHENGKPIGGLPSLDTWAGVKVPVYLIAGEDDHLTPPGEVDKILQVLNHRTNSTQSNDEHTNQEELAISSQSPTQVPSQTSDTIYDPTEESFATDKIGADSIDNADDEPSTPLESPAFVPPQPAHPTPVVQSFVMPSPANHALLYMPRCSRVLAGLISDFLACHVTQRLSLAWQLQYLSREGKWDVKNLIKWKSVAPVSEEIGPEGRPIFRALKTLREADDVHSPSEFVGTWSHVVKDVIDISRDQPVYDPRGLERGGVHYHKFPTVSKIPPQPKEVELFIKLVDKLRNAQMERADKEGWEHPEKCVVGVHCHYGFNRTGYFIVCYLVERCGFSVQEAIEKFAQARPNGIRHSHFLDRLYVRYNVEEGPGQQPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUR6</accession>
    <name>A0A7D5UUR6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986340.1">
        <property type="nucleotide sequence ID" value="XM_066130261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUR6"/>
    <dbReference type="GeneID" id="90967661"/>
    <dbReference type="KEGG" id="mbrn:90967661"/>
    <dbReference type="OrthoDB" id="4840990at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="57" mass="6770" checksum="D7F108FCB8A3EB34" modified="2021-02-10" version="1">MAAFLKNRTTYDEDKILNLIWFGLVGLQVVIVMSVAAQAARRYLRHYFQQRRKQMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUS8</accession>
    <name>A0A7D5UUS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat Labile Enterotoxin Type Iib</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g045840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544711.1">
        <property type="nucleotide sequence ID" value="XM_014689225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUS8"/>
    <dbReference type="GeneID" id="26242052"/>
    <dbReference type="KEGG" id="mbrn:26242052"/>
    <dbReference type="OrthoDB" id="4936804at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.40">
        <property type="entry name" value="Diphtheria toxin, translocation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02764">
        <property type="entry name" value="Diphtheria_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028980437" description="Heat Labile Enterotoxin Type Iib" evidence="1">
        <location>
            <begin position="20"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="74905" checksum="F59DA14AAA305D86" modified="2021-02-10" version="1">MTILSILLHFLLWSLQSCALSVPTSHDPTLDLSPYPGVVGTHESDFLLRKRQSSSDILIALYARGLNAEARKAAGIEAFHWGIHITPEGALKSEKTTSLFHVINQEENIKLFQYEKRTINPFRQRVIFARVKVGTLPATVSVDKVDELLSQVQAPSKLENPGDSCVTWAVCGIKKLQENGIIENFDTAGFADKVLEYGEQQTRALDDDEPEFEADEFDIGNYDAKEGKIIRQESVPCKRAGEPCINPNPKEKETEPAVEKPEDAELIAVAKEKSKENFDGLLEEFNYGSVVKQDKLYGELNARLPEFSAPRVERIAGFASKLGEGALAIGGLVLYGKAVADVFASEDASVLDKAAVVTSILPGIGCAVQLADDEQKGQVDVTHTALCFTEDALLVSGFWEIALVMQVGEEISNWIQAENERSKFWDGDLLAQKGAEGWLQNVKRLINHIKGDEFFVNATSQFATYQILTLYQASQLTGDLHATAKTNPQGIEADIHAHVQPELKRQICSVISDSKRQLQAKLEGIALNHTAKLEREFKNQFLDDWLKAATTPKPIFGITLPDFESNTKLIHEQVEKARNSPLQLYEKEVKAAIREVIERLPTPAPCQCDQGKKGGKCEFGGCQSTKPEGHPQDAGGRIYTANVQSIEVAKRLRLTDTCQALFAKCQGGEAGRALFCTPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUX5</accession>
    <name>A0A7D5UUX5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g008310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549676.1">
        <property type="nucleotide sequence ID" value="XM_014694190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUX5"/>
    <dbReference type="GeneID" id="26239120"/>
    <dbReference type="KEGG" id="mbrn:26239120"/>
    <dbReference type="OrthoDB" id="4250781at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF7">
        <property type="entry name" value="ACYLTRANSFERASE MBTK_IUCB-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="274"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="51809" checksum="A6F507157DF60663" modified="2021-02-10" version="1">MAAANSVVQLSALSPNETFIKLPHPYLTEYTVQKTTAPPNKTAGDVPFYQLCERPGSSTQKLPAPLHNTKLYFSEPADLKSSELPADSNNGAWARARRSPFSVVVWDGAETPSLAQAWLLLYVLFTARPGMESVRLELVGANAATLGAQLRDVLLAVDHPPPAREKRASASSNADEYLVLALRSTFWQGAGSPFGPRPVWLPAESPPSLHGAGSLASYPLTPLQHTVTITSAGDPQDADRCQQSWHPIRPAKPAPGAVVYSRWIPHLGETFSMVSLDYQDEEHLRLFHEWQNDPRVSQGWNETGTLDQHREYLRNIHEDPHQVAVLAKWDDAYFAYFEVYWAKEDRLGGYYDAGDFDRGRHSLVGDVRFRGPHRVTAWWSSLMHYLFLDDPRTMHVVGEPKNTNATVVMYDLIHGFGIEHFVDLPHKRSAFVRCPRTRFFQLCPLGENDKVVGGMRIGLVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV36</accession>
    <name>A0A7D5UV36_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rhoC</name>
        <name evidence="10" type="ORF">G6M90_00g049390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545048.1">
        <property type="nucleotide sequence ID" value="XM_014689562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV36"/>
    <dbReference type="GeneID" id="26242389"/>
    <dbReference type="KEGG" id="mbrn:26242389"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="268" mass="29894" checksum="2C41FF91CB4CE657" modified="2021-02-10" version="1">MASHYSNSYYAPASNEQPRRQERTRSSNGTVSTTVSSSSGRESAATHMTDVPAYSKKIVVVGDGGCGKTCLLISYSQGYFPEKYVPTVFENYITYPTHSPTGKTVELALWDTAGQEEYDRLRPLSYPETDLIFVCFAIDCPNSLDNVLDKWYPEVLHFCPYTPLILVGLKSDLRYKKSCIDMLKTQGLTPVTTEQGLAVSEKMGAQYMECSSKEMLGVDEIFERAILTVVANDRRNYDAMGSGSGNEKMLPIPGMKPPKKKKRRCQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV50</accession>
    <name>A0A7D5UV50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xyd1</name>
        <name evidence="8" type="ORF">G6M90_00g049650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545073.1">
        <property type="nucleotide sequence ID" value="XM_014689587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV50"/>
    <dbReference type="GeneID" id="26242414"/>
    <dbReference type="KEGG" id="mbrn:26242414"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="150"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="396" mass="42901" checksum="1FC2EDEB56AE0A76" modified="2021-02-10" version="1">MASGTPYTVKWGIMATGGIAETFCKDLLTNPATRSVHDIKHQIVAVSSSSSADRAANFIKKIDGPSTAKAYGSYAELVADANVDIVYVATPHSHHFQNAMLALEAGKNVLCEKALTVTASQARKLVAKAKEKKLFFMEAVWTRYFPLSIKIREMISSGEIGTVYRTLADLSFNENTPQTDGIVSFPDTHRMVNKDLAGGALLDLGVYPLTWVFQTLYHVQPSATKEAPRVLAAMNQYRTGADENTSIICHFPGTRAMGVATTSMLVGTSPHGDATAAPAIRIQGSKGEIQVPHPAYRPLSYSVIKKDGDGTVEVVECPIPTDPARGNWGHGMFWEADECARCLRDGKQQSATMPWDESIVIMQTMDDALRQGGVAYPDLITTDVFDAKSPLNTGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV84</accession>
    <name>A0A7D5UV84_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">37S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RSM19</name>
        <name evidence="5" type="ORF">G6M90_00g030930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
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</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">4556</strain>
        </source>
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    <accession>A0A7D5UXC5</accession>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">4556</strain>
        </source>
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            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1191"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1266"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1341"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1419"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1460" mass="160059" checksum="EEA79F79E082C170" modified="2021-02-10" version="1">MEPPVKRRRLGEHPQLWDDDADGDDEEWEEYDEDDDNDNGESAPEQCEGSVEQDDGYQLAIEKAYADNRFRATMAHIFRKYGRDFEGIGDEIDLSTGEIVVNNGHIENMRNEVDVGDVPRSHNGDTDDDDPHEEEEEEEYEYDNDDDGVLLEDLPDDESGQYYSCKQGASDALEEDDASQSWTSDADDAEPTPGNMQLQRLQQSFNPDHVDAIPGYDPKKKGGPGLMSGLYGGGGLRYASALGEFGASPLALGPWDILPQTQERYEFPTQDGSSSIWAPDYRFNDNEPDQRPSVRARSGPSKMRLKAKKPKALPPPWVGNRGVAPGGSHKRPGGVPKQHYDTSSNRKQMMPLGDLSWVETMEESDTIDDAVFSAGEVPVSSDTGDTTDEVPQPKPTPPSEPTPRIIPDSQDSYASLGNQPTQSSAKSKLPQPQRPKHRDFSSACVLSDDESPLYSPLLGSSSTTDPTESARALPNATAAPASDVNADGTVVKRGRGRPRKYPPGYRPPRTYRRKPKPPLLELPGLTRPLTVPTMSNMSFMPTMTTAPMIQPNIQSTIQPKTQQIRTETAPGVKRKRGRPRKYPLPGAMPQQTPKSPAEKQSQQSQQPAGQGPLLHTFQPGFQQQGFQYPFNPLFHQPLFQFPQQTAYQPWHPLQQSYIPHPMFQFQQQIAQQPMPQLWQQPNVPYRSAQPQSSSQPVKKKRGRPRKYPVKFDSVYPGYVMNRKRSASKKMYEGLPSHQQLPGLQNSMTALLCGQSGRMMVSEDAWYGVARQLAQDIACLQGGSLFSSQFQAGPSASSKKASQSSSKKTGRPDPDFSASPEADDEPVRITELSEVSDMEVTSTAQLSCHVEHGVPVQDERAVTDQEFVDFPSDGNVGNVFDPALGERPPAELDMFDNASLEPPPFGSDMIDPALIDPALTEEAPVDFSTAESGTTERTSMEPDTFDPACIDPALLVEDSDSPMEDDDGGFVIMQSPPRSVTGGAQPTPSPPSPPPSIKKSSLLKGTDRCTPSPAPEHNVNSHTPTSLESAKASAPVWHETENFDLPSSPEPFNPRITIRDASEKKPILEPGEAVDHPPSIATQGDSDLDDSHENSGQACAAATTTPTATEYPAELPLTEAVDAPVKLVVREQELLAGNGEPLDSAATSGEVVPKVVDSCQQPDDESEKSEEPVLQPPQRMERREDGPVQPLAHTNPSSKEITTPRTPEPPTAVEITNQTPAKFSEGRSPKVPRSSKRCTPIFLESPIFVKSPTRSPTNTPRPPKRQHTIERRTMGELKKAILQPRQRAPPPKQAMQKPKPKPIEAEIRRSSITAKSRTKLPDVLVGNSSKISRIDRLPVSKPTMSKSSVSNPAESKIMSQAKASTAIKKPNSRRSLLSLVSGDGNNQDIDDEVDELGNLVKSKSSSSTKSNSILPTNVSQDKKLKSAAEARQARQKPLGEKPQKDKQPPEEKLPKGMVYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXJ3</accession>
    <name>A0A7D5UXJ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g033580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543285.1">
        <property type="nucleotide sequence ID" value="XM_014687799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXJ3"/>
    <dbReference type="GeneID" id="26244086"/>
    <dbReference type="KEGG" id="mbrn:26244086"/>
    <dbReference type="OrthoDB" id="3946796at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="76220" checksum="640AE1901680EDD5" modified="2021-02-10" version="1">MSRAVALNSSHRHEAQSFDIFDDRSLTPDKHAHVDATGNSDVLKELSHGQSQNRVTPAVLAKSPRRDPTSPENKAAKAQSNRRASRARRPQIDSETFEPLGAVPEETSSLIDPEENLVAISPATKDDKVNGYHTKLNEDHLPAILDPKSALEGQVEKHLAGQFEWIMTYPAEASSQTANGPQDEYNAGSESRSQLYGCNLLPVRRRRTSQTGSGIATDIYTLLATPLNKDSYPTPQTMDGTRSADSLVSLAMSQAPPPPYPGTPLKAPEVVTMVEQAISPSLTIMSENSPSVVAGSSRTGSFSIPRIEDSLEELDRLEEELEAIHDLTLPRGSTTANTQASEPNPVTPSGVTPSAPAKSKEASVAGCSATVRARPSQKARPSLRRSASLTLRGKRRAQQESSESQKSESSVSRSQSSINRLSAPKHPIKSAKPPTVPKFELPGEAVARRLKEQREARQAQQQAEAQRTQAAIPKPRVTNKPLPKPTFELPGEAISRRKREEREAKLKAEEEEQRKRREFKARPVRHSIGPSTLPRETLTSRARQSRASPEANGENDSQGAQRKRMSVGVVRSVPVPSQVGNSSQTRGRNSTIASATEESRAASTSTGSAGGKRISVSLEELHVQRQRGKDIFTRDNCYTQDREKSKRERELAAKTAREQAAERSRIASREWAEKKRLRELAAKRAKATQEAGKEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXX9</accession>
    <name>A0A7D5UXX9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-linked oxidoreductase easE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">easE</name>
        <name evidence="7" type="ORF">G6M90_00g054480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540956.1">
        <property type="nucleotide sequence ID" value="XM_014685470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXX9"/>
    <dbReference type="GeneID" id="26246262"/>
    <dbReference type="KEGG" id="mbrn:26246262"/>
    <dbReference type="OrthoDB" id="4940433at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="396" mass="43113" checksum="85CBDBE82E19A501" modified="2021-02-10" version="1">MGAGIMHWEVYSDGAKNGYTIVGGECPTVGAVGGFLQGGGVSSFHSFTKGLAVDNVLEYQVVTANGELIAANENQNRDLFWALKGGGGGTFGVVAQATVRVYPDDPITVAAISISTSLTNSLFWTEGVSELLRLLSIFNQQGFPGQIVVMGPNQGSLQATLEFHFPNTTDESYVNGLLNSQMRPLWDHKISTNLSIRVQKKASSEVRLGPDTYPPQYGIVQGSVLISAALFNSADGSPLIARNFSNLNLGPNDILFTSNLGGRVMDNSDIDIPLHPSWRSAAQLVTLVRAVEPSNKGRLSALETLHSHDMPILYSLEPKNKVSYRNLGDPSENEFQSRYWGSNYKRLASIKERWDPDELFTTRLGVGSEEWDTEGICRKSIGLVARVSELLRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXZ3</accession>
    <name>A0A7D5UXZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g053980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541006.1">
        <property type="nucleotide sequence ID" value="XM_014685520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXZ3"/>
    <dbReference type="GeneID" id="26246312"/>
    <dbReference type="KEGG" id="mbrn:26246312"/>
    <dbReference type="OrthoDB" id="4960511at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015791">
        <property type="entry name" value="Antimic/Inh_G_crystallin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015161">
        <property type="entry name" value="Sklp_toxin_b/g_crystallin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09076">
        <property type="entry name" value="Crystall_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028852572" description="Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Streptomyces killer toxin-like beta/gamma crystallin" evidence="2">
        <location>
            <begin position="49"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="118" mass="13012" checksum="B98B518E350B645A" modified="2021-02-10" version="1">MFRSILVVLLTAISYILPGAGAIEEVGVASCMFGTDFFTLSYTIRSGATTLSRCFADAGEMEMSQSDVVSYSSGNNKGWFDYEPGDGYLYRHSFNKSNTIFIHGVDTTWGRVVKIHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYI3</accession>
    <name>A0A7D5UYI3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 1 regulatory subunit SDS22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sds22</name>
        <name evidence="4" type="ORF">G6M90_00g057490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544330.1">
        <property type="nucleotide sequence ID" value="XM_014688844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYI3"/>
    <dbReference type="GeneID" id="26242742"/>
    <dbReference type="KEGG" id="mbrn:26242742"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001078">
        <property type="entry name" value="Protein phosphatase PP1 regulatory subunit sds22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="377" mass="42410" checksum="DECE69E15F18FD47" modified="2021-02-10" version="1">MSSAPDKETDHPHHIDIQDDRVAPREEGDASPGMRNSKGWDGKLRISKSALLSNPEALSDPEYSDDSNVLPGEDIRADEDLLESESSDSEEIMCSHSRIGSISSLRLERFKNVARICLRQNTIQEIEGLAPLAATLKDLDLYDNLISHMRGMDELKNLVCLDLSFNKIKHIKNISHMTELKELFLVANKISKIEGLDTLQKLTSLELGSNRIREMRNLDNLRNLEELWVAKNKITDLTGLGGLSSLRLLSIQSNRIRDLSPLKEVPQLEELYIAHNALESLEGIEGNTNLTILDISNNQIRSLKGLEGLSRLEEVWASYNQIGDLVEVEKVLKDKENLTTVYFEGNPLQLRGPALYRNKVRLALPQVSQIDATFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZF8</accession>
    <name>A0A7D5UZF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterigmatocystin biosynthesis monooxygenase stcW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986899.1">
        <property type="nucleotide sequence ID" value="XM_066130582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZF8"/>
    <dbReference type="GeneID" id="26246266"/>
    <dbReference type="KEGG" id="mbrn:26246266"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF1">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE STCW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64561" checksum="F5BEEEB9FCEDD2E6" modified="2021-02-10" version="1">MPSDQKTRCIVIGAGVSGILMETLGDLEDLTGIKLAYKLQHYLNDFVEFQILEKNPDLGGTWYENKYPGCACDVPSHCYQYAFAPNPSWSKLYSSSEEIHDYLKKVVKHFNLERYIRYNTKVTSAKWTESTGTWSVGISDGTTIDCEILINAGGILHHPQLPDLKGLKSFAGKVVHTAAWDSGLDLGGKKVALIGSGSSAVQILPQLQPVCSSVRVYIRTPPWIAPPMVDTESESPNRDYTNDEQAFFRQDPAKYAQMRKEINSNLNGMFKALFKNSPEQQNFRQMLETRMRSLIRDESLQDHLVPKFEVGCRRVNPCEQFLYSIQEKNVTAVFNAIEEVKPHGIVSEGVEHPVDIIVAATGFNNSFRPQFPLLGRDGVNLQDIWADEPTSYFGTGVSGFPNYLTFLGPNTPISNGAFMGPLEGTSDYFIRLLQRAIRYGASSFDVKPEAQADFDSRVCEFMKKTVWTGSCLSWYKKTRDGKITALWPGSSLQYMQVLAEDRWEDYNWAYRGRRYDYWGNGFSWIEQPKSDKLGIQERKSKNEMVTIPNIDADLGFYITQQTPLPEADTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0L4</accession>
    <name>A0A7D5V0L4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HET-E1_9</name>
        <name evidence="6" type="ORF">G6M90_00g068770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540015.1">
        <property type="nucleotide sequence ID" value="XM_014684529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0L4"/>
    <dbReference type="GeneID" id="26247235"/>
    <dbReference type="KEGG" id="mbrn:26247235"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="115"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="435"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="933"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="966"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123134" checksum="EC03DCEB19830FA1" modified="2021-02-10" version="1">MFLFPFPGLNQDFTLPQGAARAVSPIYFVLPIVLIFSFYYLRRSPPESGKLEPENERIDSSERTKKTPGDESFANLTPSEGVSPDEGNASNKTLPPAAEPGLQILHDSDAPKIDIVAVHGLGANPDYAWVWLPKNNPPNRRGYPDKPFNWLRELLPAKISKPCRVLAFNYDSRWFWDAPQQKLSSISDTLLDSLRNDREQNKAIDRPLIFIGHSFGGNVIEQAIVSASRHCSPHLSISASTIGVVFLGTPHRGSPAAAWGAIIASLMPSGLAPEDRLLKALEKHSDSLADRLRDFSGWLFSESVPVVCAFEQLVTDYSSRLPLLGTFVPSRTLVVDEDSACIDGHHKISLHTDHLKINKYYGADDPSFKLIYPEIQRMVEGTDEGLNRRRNPKPIPTDETSTSGGLQRCLQRMRVKNPEDVLSKIEAQKGQRVENTCEWILKREEFSAWAVGTNSHLLRLIGSPGIGKTMMATFLVRFLKCKIEKNPSETFIHFFCDDKDQERKTPTAILRSLVWQLLLQRNELFEHVQPDLEKYEESRTFDSLFNDVYALRRILKNMLLDERSDKVFVLIDALDECEASTRKDLLPRIQIISQLSPAGDSGKIKILLTCRPHINDIEDELQDVGTQLQMGSAEINHDLAKYIDDRVDELANRKHYPLSLKQKVIETLKRESGNTFLWVSLMIAELKTTLMHKVEEKLNRLPHGLDNTYSTILDRIPDQNRENAQFILRFMVAALRPLKKTELQAAYATWKTNSILSGEDMQLYSDILSVCSSILHTGSEDNATLNFCHQSVKDFLLDEHTANTWYHTSVDEANILIFKVCWMYLSADKFSQSRLNFCHWSLRIDFDQTNKLIDQRGRFSLHLFVEYSYYAWKQHAIRSHKALLRDWHNLAIDVTKAPALRDALLYWTAQQGYEDMINFLLDQGANVDVKNVLGATPLLNAAEKGHNTIAKLLLDHGASMEIEDTDKATPLLKAAQNGHEIIAKLLLDRGANIKATDKFDDGPLLTAVEHGRETVVKLLLDRGANIEARNTSEVTPLLNAARGGHESIVKLLLDRGANIEVKNKIGDTPLSIAAVRGHMGVVKLLEQYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0Q4</accession>
    <name>A0A7D5V0Q4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosylphosphatidylinositol anchor biosynthesis protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gpi-11</name>
        <name evidence="9" type="ORF">G6M90_00g077040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545398.1">
        <property type="nucleotide sequence ID" value="XM_014689912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0Q4"/>
    <dbReference type="GeneID" id="26241431"/>
    <dbReference type="KEGG" id="mbrn:26241431"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="251" mass="26346" checksum="A4C3D4E7891260FB" modified="2021-02-10" version="1">MSSTLVTGSSSQLTDTKFSDVIPSVAVIDTPLSKSIALLRPGLILGLLALRFNSLVADPVPTLQLALPAVALVQTVYAIICLPVAGSQSAKVVRKPRPGEKKKADINGPNTISTAILALLLSAIATPAVYILFVLFGAPFLDHVEHTLLCSAHFSLLALFPIFYSRGVKAETLVAVAGASAPLDETFGGLVGAVAGAWLGAVPIPLDWDREWQKWPVTIVVGMFAGSLLCSSVSGTLLFGKRLSSNEEKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0X2</accession>
    <name>A0A7D5V0X2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyoxylate/succinic semialdehyde reductase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GLYR2</name>
        <name evidence="7" type="ORF">G6M90_00g081430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543382.1">
        <property type="nucleotide sequence ID" value="XM_014687896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0X2"/>
    <dbReference type="GeneID" id="26243559"/>
    <dbReference type="KEGG" id="mbrn:26243559"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="160"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="289" mass="30342" checksum="D0D34A016AACB5F0" modified="2021-02-10" version="1">MRIGFLGLGRMGTPMALNLCKTYPTTVWNRTASKYPALTAAGAKIGHTPAQVAQHSDVIFTMLFDAPATQSVFDDGLKRAIRNKTIINTSSVPVEFSQELERQILRAGGSYVEMPVSGSKVPAEQGRLVGMMAGDEAVCERVRPHVQPLTCASVYCGPTGSGLKMKYAINAYLITMTAGLAESMSLAQAQGLDLDAFAEVLAAGPLASAYSGLKVGKVLAGDWSAQAAIKDCYNSTQLIRAAAAAAHTQSPLVRLCGELYSQAKASGMAEDDMIAVFKVLAGSTATPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V153</accession>
    <name>A0A7D5V153_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Target of rapamycin complex 1 subunit mip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mip1</name>
        <name evidence="7" type="ORF">G6M90_00g092200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541864.1">
        <property type="nucleotide sequence ID" value="XM_014686378.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245332"/>
    <dbReference type="KEGG" id="mbrn:26245332"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="164"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1289"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="948"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1404" mass="159436" checksum="2DB828B0C20A2A0C" modified="2021-02-10" version="1">MTLRSDLNGSLPSAPTTNGIGHGNGETSTSRFRGQGDSSPDRDDLSNGTGDNIRPSSAPGRKNGVVFVESGDELGERPENHRVKPPLLRAKSDFAPRSVEESDTEEEISEWGARHGFEDHYQSEHIISQLASNWYMYFTDKRHETTGKPKRLEYELQDWRQRDRLKTVSAALAVCLNIGVEPPDQLKTTPGAKLEAWTDPTVPPIQKALENIGKALQTQYETLAIRARYKQYLDPSVEETKKFCVSLRRNAKDERVLLHYNGHGVPKPTASGEIWVFNKTYTQYIPVSLYDLQQWLQAPTIFVWDCSEAGNILNNYHRFVEKHEEEEEEAADRDPHYEKTSFRPYIHLAACAVKENLPTNPQLPADLFTACLTTPIEMALWFFVLQNPLKTNLTPERAKQLPGRLQERRTPLGELNWIFTAITDSIAWTTLPRDLFRKFFRQDLMVAALFRNFLLAQRVMTVYGCHPQSYPALPDTHQHPLWETWDLAVDMALAQLPMLERKESESIEYEYQNSTFFTEQLTAFDVYLTRGDAMAQKPPDQLPVVLQVLLSQQHRVRALILLGRFLDLGPWSVQLALSIGIFPYVLKLLQSAAAELKPVMVFIWARLIAVDISCQQDLIKDSGYSYFAQILKPSEGLPVVDGDEHKAMCAFILAMLCKDYKNGQMVCNQTDIMSYCLAHLQNESNPLLRQWACLCISQLWQDLPEAKWRGIRENAYVKLAYLMRDPCCEVRAAMIHAMTNFLGIPDLTDEVARIEESIAWTILEMGTDGSPMVRKEFINFLSHFMIRFESKFLVAAYEQLQEEKEYLIFPPQDDGQDHKMGLHYARPENRNKDGTIKPMAHGLSHNTVYMACWKHALILSVDPHPEVQREATIIVDYMHNALINSTVGEAAQLLMREIQTRARQTAILRNAAQAAQKSHTVGGQATQPLPSPGILRRTASLLFQSFIGSEERSRPSTPGSPVPPRSPSKLAPDQMAAPPEQSDLSSATYNVAREPMTGAYEERDLSRAPSMPLKSRFLEWSIEYFREPQMKPSEADEPGSTEYNERLWRRARNENMLRETQPLKQMAGTHKWNNQLGIVNNGAQPAKMTFHQYEDHLAVSDDGNTVYVWDWKKQGRLSRFSNGNPQGSNISDMKFINEDDQAFLLTGSSDGVIRVYRNYDSDKEIELATSWRALTHMVPSNVNSGMVFDWQQVTGRILVAGDVRVIRVWYAAHETCVMDIPARSGSCVTSLTSDQMTGNIFVAGFGDGAVRVFDTRLRPQDSMVRKWKDESDRQWIKSVHMQRGGQRELVSASRNGKVKVWDIRMDRPLHSFQTTRDTLRTASTHEHLPVFAVGTSQHAVKVFNLDGNELSRLEPYSSFLQQNRGVPIAATAFHPHRPILGCAARGDHHINLFTCEKTEALHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1Q0</accession>
    <name>A0A7D5V1Q0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g089860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987462.1">
        <property type="nucleotide sequence ID" value="XM_066131363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1Q0"/>
    <dbReference type="GeneID" id="90968102"/>
    <dbReference type="KEGG" id="mbrn:90968102"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="91" mass="9933" checksum="4177618B2B4E2B48" modified="2021-02-10" version="1">MVDEEEEVEPECAKDELELGLLAVQEVDVILFRLIAEVSGVSELESLLVLNSLESKVQDSCVDVWSLVDIVQRPISSEQSVVGVFGLSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2U4</accession>
    <name>A0A7D5V2U4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g102080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546138.1">
        <property type="nucleotide sequence ID" value="XM_014690652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2U4"/>
    <dbReference type="GeneID" id="26240561"/>
    <dbReference type="KEGG" id="mbrn:26240561"/>
    <dbReference type="OrthoDB" id="5419666at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="284" mass="30865" checksum="E561DEBB402573E6" modified="2021-02-10" version="1">MSLSRAFTTRRLRGGSDLADSAKIPQRSNTTKIPYNIRDKISAPVQLLHTTNMLSYNAPDIPRSSRSNSTTSKSGSDVESQDTADSTPPTSPDVSSLPEPNHLSSYFKPAAPASTTLPVKAEPPAIPKRSPSHTKKNSFEAIARQRSVSRMSRDSDHFISTKAGQPFSRPHSTSTRASSASHAPSPFAQKQSTPAARPNKSTASTQAQAKDSHPFGHELAQVTELAEEYSVNSCLDTIDEEQQYLDNRGLKRLSPDDYLSAIQGLSTMFFPERSHATSAAPLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V318</accession>
    <name>A0A7D5V318_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">G6M90_00g088800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542235.1">
        <property type="nucleotide sequence ID" value="XM_014686749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V318"/>
    <dbReference type="GeneID" id="26244749"/>
    <dbReference type="KEGG" id="mbrn:26244749"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028835403" description="Inactive metallocarboxypeptidase ECM14" evidence="16">
        <location>
            <begin position="26"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="17">
        <location>
            <begin position="190"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI72551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="545" mass="61277" checksum="245ABF5DF0567342" modified="2021-02-10" version="1">MRTGLASLVTSGLLLVVQHPGLGFAAGLHPQRPSNTGNRNTHLFPFLTKLRDSAVELLFGRHPTKNADQHAVPFSLRARYTNELVLRFNVTTPEEEIALAQAAARLFLDIWAFTDEFVDIRMHRDEVSPLLSLLPPSLQVAQSTLISDLASAVYNSMPSYHEKPTVEAGEALSVSTSPLSEANGNLFFQDYQPLPVIVRWMRLLEAMFPSYVEYFSIGKSFEGREISALRVGLSSTIDPTKPRKTIVVTGGLHAREWISTSTVNYVAWSFITSFGKERMITKLLHEFDMVFVPVLNPDGVDYSWQVDRLWRKSRQQTNIRYCRGLDLDHAFGYGWDGTQAQADPCSESYGGEQPFQAVEAMRLATWARNETLNNVKFVGLVDLHSYSQQILFPYTFSCQAMPPNLENLEELAAGIAKAIRLADGESYSVTSACEGATGRQDQFTPRVESGGGSAIDWFYHEMGAHFSYQVKLQDTGTYGFLLPKEYIVPSGEEVFSAMKYYGDYLLGNNGIERLLEETTRDDQLESPAYDDVQISQELKRRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V327</accession>
    <name>A0A7D5V327_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">U3 small nucleolar RNA-associated protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">utp20</name>
        <name evidence="4" type="ORF">G6M90_00g101010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546244.1">
        <property type="nucleotide sequence ID" value="XM_014690758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240667"/>
    <dbReference type="KEGG" id="mbrn:26240667"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="904"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1721"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2446"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2585"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2448"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2606"/>
            <end position="2622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2636" mass="297761" checksum="81C0C255E1986251" modified="2021-02-10" version="1">MPSKSSGRIEKVRKNKYSTPHQKNHRWESFSTKISKFNSLQPLRKVRRHDLENEDLSTATSYFHNGLQKWSELNISKPFCFFRRDVLPLSESLPQILHFEDKIMGYLAQYISLGDKDALEPLLDLMTAFAHDLGVRFEKHYLQSINLLLDIAGKTQPVEVIEWTFGAMAFLFKYLSKLLIPDLRPTYDLMAPLLGRSRHPQYIARFAAEAMSFLVKKAAAPSHREMALKSFVEHVRNDLIGAAETHQFTLYNDGVMTMFAEAIKGTDGMIHSTGGAIVSALIDAIPENECTLSRENIWSDVICGVLTSVLHHGRADTMSEFLEEIFTKLRSKKELVEGAQVQWKAVPYIKILGVLAGVRRGSRISNWDGLLRDFTDILSMTGKESKEIRPDQVDILWNSIMIKVAIVWHHAPMDALIPHIATLNQTLTKEPFMRWFIPFCAYFCDLDTSRFGSLFRSEFQRFVAGHWSQGKNEDVLCVLLPKMIKIWAFPPLGEKDCCRLPQAWQDQIVSKFERLEISPFPERGPYNKDPQEWRDRCLPKYAGLLQLLELTAVHPSTNARIAELLSRKLKLALRPSSSLASDEVHFIVSQGFHAYLRMSKAAGSIDTSLSPLLRAAVPRFARSVGFLQAYLAYEKAHQTGAPATSDKMEITGGDSPTSEEDPMVVSLVENLSSPSHEIRLASLELLKRMSETEALTNCVETMLQIEQMPLSHENTRTIAMHLRKIGLHYNAIDASTWLRDGIPRFIFGLLTVKLSPVWDEAVENLKYLTQSSIGEEAVSAIAFQWINRPSTRWTPPNPDSAGGDRRFYTDFECTALGRLEQLANVIQDLTEKADDSLLKNFDEKQHLAEHTPPTARSRALKVFNAAPAVAEKRSRQLVPHFLCWAIEEDEADGSEAARAQASTWSLADRKALLGVFAQFINPKVLYQHEKVYEALLLLMENGDVEVQKLALKAILSWKQDGVKAYQENLEYLLDEARFKNELAVFLQGEDVIKPEHRSELMPVLLRLLYGRTIAKKGAASGRNGLQATRLAVLRNLSVEDMGSFLEIAAGKLKHVQVTVTKAQRKKLFSEPIITTRKQVGFLNMISSLISELGANVEPYTNTLVNAVLYCLVYSSRQLRGTSGDDDARDEELDEKVSDLSLLKSARSMGIKCLTALFQNAQKFQWDPYQELIIEEVVAPRLDLLPVETTQGVSGMLHLLSTWSALPKAAMFLGPHGEVLPQGVLPNLVDCISKEKTKDEVKIFVLTILQNLVKLALAPAQESEFNEIIKADLLEANATEILSKITVVLHTGGISNALLEASVETVLALAPVLQDLDNTQTVIRMCSFLLQQPPRRVNPRTKGRILLIVERFVALHDAAKDQALLSDVYNTLSSLFSYFKDRENRHSLSRAMLAISQQDSEVAEIASLCNELNTFKEGRIDEPDYDRRLAAFNAISMVHDVPWSPKQWLPVIHNLIFFIRMDEEFGVLSSNSADGMRRYIQDVANCQPDEVKPTFDNQMRTVLLPALYAGSREQSGTVRREYLRVMGYIITVMPGWEPVADLSGLLTERNEDSSEPSFFFNILSPATSRQLEALRTLETANTVKQMGSPNLSQFFIPLLEHFIYGREYGSDDHGLGAQATTTIGNLALSLNWNHYRMTLYRYISYIESRPEMQKSTIRLLGKFVDALVLSSEKNKNDGTDVDGDEVKATCLRLQATVPTITKLSVDVLDYILPPLIKHLHEKDESEVSYRVPVGVVVVKLLKLLPPEQMEQKLAGVLTDICHILRSKAWEAREMARDTLVNIAVVLGSSFFGFILKELRGALTKGYQLHVLSYTMHSILVATIPTFATGDLDHCLPSIVTVIMDDIFGVIGQEKDAEGYTTQMKEIKSSKSQDSMELVAKNASIRHLIDLVKPLQALLLQKVDLKLVRKIDALMGRIGSGLLQNPDAGSRNTLVFCYEIIQDTYRSQKPEEAPRMDPRVRKYLVQKGAKRSGERGSTTKHTYKLVRFAFDTLRSMFKKHEDLRTPENVAGFLPIIGDAIIDGEDEVKISAFRLLATLVKVPFNSEDGTGIYRVAVKEVFKSISQSTSTTTEISQAAVKLLAVLLRDRKEVVVKDAAVDMLLGKLKDDFTEPLYRHVTFNFLRSVMVRKIETATVYDTLDYVGTVMITNDDKDTRDLARGAFFQFIREYPQKKARWAKQLNFIVANLKYDREGGRLSVMEIVHLLLMKSSNDFVQEIVGTCFLPLFFVLANDDSEKCRLSAGELMKEIFQKADKERIQHILGLLRTWLDKEDNPAVQKLALQIFGYYFESYGDAQNNKKDCRLVLNRSAAILKAEDIKNTNSQLIETTLGVARLFGGCMSEEALSAKREELWRDVARYLRHPEPSVKLAAVRSVNSYLADFARQRTEAFIGEAIDGSYGLTLHLEDMYNFTRLALGSLNSNDIDEDLASELVQVIVFLGTCLPVSTTVETDVEEDEDEEQDEDEAVSGQREGVGYLFWRLSHILRREIPPRSLAINSKVAAMEILETVCRRVLSTPGRPPLKTVLVPLQQLTDRSIPAPFSNDEVFKTKLEGVKTRAQIMMDSLQKKFGTAEYSKVLMEIREEVKARRQQRSSKRKIEAITQPEKYGRDKRKKFEKNKERRKVRSREQKQARQSFKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V375</accession>
    <name>A0A7D5V375_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g091020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541756.1">
        <property type="nucleotide sequence ID" value="XM_014686270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V375"/>
    <dbReference type="GeneID" id="26245619"/>
    <dbReference type="KEGG" id="mbrn:26245619"/>
    <dbReference type="OrthoDB" id="4588713at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="601" mass="65274" checksum="D3AE8872644FF510" modified="2021-02-10" version="1">MDTAPLADIETTSSPAIVDSAVASSSPQPTYTTAGTIYKPSSSQPLQPPTRRGRLPKWSDGNIHSKLALFPKSSLPGMSMKALGGRPNSALQQYTPLQQNNHRAVSPFSEPDHLVAKTPIETPRIHLGNLPNALSAPTMPENSSQEKAATEDGEHCSLDGSDDDSEDSESKITLLMNMPVKSLYNLASYQNPTQKYAQRALKRGTKRPLTLGSSSMGSTTSTSPPTLSAFNPPSSSNEIGGPSNLGHQGPTDIFGFRRGELDAAFRVDDMWDARTGTPTPPFPNHSRINLTFGDAPNPVGNSASASGTLLPLTAGPPGQRQYRPVAVESTFRPFVSAGPSALPTSNPADEDTLQIANRVLFEAGIEDVSIDSLGSLFAENLHSAPSSYPIWDGGAGNAEPRGSVLPTEPVYEDETQNQFRNITGPMERMKVWDPNERLIQTKSWRDPSPEVRALYKPGTDRLTDEAMAARKTELNKWWYSRVDKTDNETGLENIPGNIPFPQSLPRADQDFGVIGDRRLKTPKSLSEKASAGEASVEETTKQTTEKTTYVTIRETTEDITEETQETTQETTEIFTSENAGSLLETHSIREAKVERAQQQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3B7</accession>
    <name>A0A7D5V3B7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial distribution and morphology protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MDM31</name>
        <name evidence="12" type="ORF">G6M90_00g109760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987809.1">
        <property type="nucleotide sequence ID" value="XM_066131792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3B7"/>
    <dbReference type="GeneID" id="26243267"/>
    <dbReference type="KEGG" id="mbrn:26243267"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI74096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="648" mass="72903" checksum="1DAEDE2B4BCDBF96" modified="2021-02-10" version="1">MSKPSGMVARTPYSNSNNSALHVILLYEAHSPFDRAIEALPQQQQCSYSNEKKPAKEHAIARGSSTSPERKRPESSQQQQEVPGQPNSEGDNESIASSVSKYLHLPTLPHRPAKEELLAAANGFWERLKVRFKWMSIRSMRPWNADEWGAFVSWFMLGHIVWILVGTTTFFSLLIFSINTVFAQETLAKWVGDYLTQSAGVTVVFESAIVPKWKNGVIAFRNVFVSRRPGQVKSSVSKGSSDAAAVAAAGRQAHLIEYSDPEDDGNYTQFDVTIANVNVTLSFLNWWNGKGLLKDVEVNGVRGVVDRTSVQWPIEEVDPLSYRHEHQPGDFEIESFKLEDLLLTIYQPDGFRPFSVSIYSCELPRLRKQWLFYDFLSANHMSGSFDGSLFTIHPRQVHGIVSRQDQGAMMGLGEQNAWQKFSRLRIDGLKIDHLNRGVEGPFGWIYEGNVDIVADVMLPAETDEGITKVMADFYDQLEEAVIMNKQRLLQNSTDNSPVLLQSGHLSEAGHVDATENNEGGEPGEEDRRYIIMDMRIHMNDVKAAVPLFTRDISYVNQALVRPIVAYINAKKTYIPISCRIVKRLSDFDGSWTVFDCGLMNDASVETYDAFAKDVENQQSRVRRFKKVGFWTLSLAVHALFMGMAGNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3R4</accession>
    <name>A0A7D5V3R4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">coq6</name>
        <name evidence="11" type="synonym">COQ6</name>
        <name evidence="13" type="ORF">G6M90_00g102810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546067.1">
        <property type="nucleotide sequence ID" value="XM_014690581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3R4"/>
    <dbReference type="GeneID" id="26240490"/>
    <dbReference type="KEGG" id="mbrn:26240490"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="38"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="487" mass="52751" checksum="998C001BD959AF3D" modified="2021-02-10" version="1">MAGARGLITTSNSVCRSCSRPARSQWRRSYSTTKDDIYDVVCVGGGPAGLSLLTALRASPITSRLRVALIEAQDLAKTAAFSLPPTQFSNRCSSVTPSSAQYLNTIGAWTHMKRDRIQEFHEMQVWDGVTGARIEFDPPASSGPSNTIAYMTENLNLTSGLLKRLKELGSIDIFDNSRVEKIDLGEETEDMDLRDWPVVHLSGGQSLVARLLVGADGANSPVRTFAGIESRGWDYGRHGLVATLQLEGDGWGGQFSKIAYQRFLPTGPVAMLPLPGNYSTLVWSTTPENAALLKKLSPKDFIALVNAAFRLSSVDLGYMHTQTEGQEDEYNWRLQHTPVDAEAIPQTVVGVQEGSIASFPLKLRHADTYIGERIALVGDAAHTVHPLAGQGLNMGQGDVQSLVKAIEYAVSHGQDLGTQLSLESYNSERYATNHVLMGVCDKLHKIYSVESGPLVGLRSIGLQAVNMLSPLKNFFMGQASGTGVKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V449</accession>
    <name>A0A7D5V449_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g105850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987767.1">
        <property type="nucleotide sequence ID" value="XM_066131686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V449"/>
    <dbReference type="GeneID" id="90968208"/>
    <dbReference type="KEGG" id="mbrn:90968208"/>
    <dbReference type="OrthoDB" id="4958508at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="74"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="290" mass="33697" checksum="B3360D54B7C5816B" modified="2021-02-10" version="1">MSPLALTKLIHESLVHITSFRLERFCRRTNEEEEKYLEEFREHVLSSLPENLENFHYFADNFRGLGGPTPVQTKPISFMELLYNHGHRFKRVSVVEPLDTKNRIAEMQCPSANALTTPLLPAQWHKLERVCFRSGILRPDNDLGLINRLLLLTAPVAENLPNLVSLEIFNTSIDRYKCDVPSCLFRYSVEHSDAMLLWESYWQLPLDTKTAEFKFCPEVKYAWEKAAVAHTGHGITILINEPKGTTEADVELRHRYWQRGEPRLAEVFKLDAIHPFTRTLMSLECQQELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4N5</accession>
    <name>A0A7D5V4N5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM2</name>
        <name evidence="11" type="ORF">G6M90_00g102970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546051.1">
        <property type="nucleotide sequence ID" value="XM_014690565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4N5"/>
    <dbReference type="GeneID" id="26240474"/>
    <dbReference type="KEGG" id="mbrn:26240474"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="98" mass="11148" checksum="6B118ABD08696402" modified="2021-02-10" version="1">MLFFSFFKTLIDHEVTVELKNDIQLKGTLKSVDQYLNIKLDDISVVEELKYPHLSSVKNVFIRGSVVRYVHLPAGSVDTQLLEDATRREAAAQQAKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Q9</accession>
    <name>A0A7D5V4Q9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">V-type proton ATPase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vma-2_1</name>
        <name evidence="7" type="ORF">G6M90_00g113910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987894.1">
        <property type="nucleotide sequence ID" value="XM_066131904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Q9"/>
    <dbReference type="GeneID" id="26247525"/>
    <dbReference type="KEGG" id="mbrn:26247525"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="5">
        <location>
            <begin position="96"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="6">
        <location>
            <begin position="332"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="453" mass="50422" checksum="CD316677B960C00E" modified="2021-02-10" version="1">MADAREPSYSVRPRVQYNTVNGVSGPLVIVENTKVRFSGQSMKLGVAEDMLGRVFDGSGKVIDKGPKVLPEDHIDINGSAINPYSREYPEEMISTGISAIDTMNSIARGQKIPIFSASGLPHNEIAAQICRQASLVKHHGVTNKSVHDGHEDNFSIVFGAMGVNRETARFFTRDFEENGSMERVTLFLNLANDPTIERIITPRLALTTAEFFAYQLEKHVLVILTDMTAYCEALREISAAREEVPGRRGFPGSMYTDLASLYERAGRVTGRKGSITQLPILTMPNNDITHPIPDLTGYITEGQIFIDQSLHNRGIYPPINVLPSLSRLMKSAIGDGMTRKDHADVSNQLYAKYATGKDVAGMRAVVGEEALSAEDKLALEFLDKFERQFLSQGQFESRTIFESLDLAWTLLRIFPKEQLNRVPAAILDKFYQRARKDVDAEAKLQKDIAQNHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4U2</accession>
    <name>A0A7D5V4U2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucose 4-epimerase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UGE5</name>
        <name evidence="6" type="ORF">G6M90_00g094320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540796.1">
        <property type="nucleotide sequence ID" value="XM_014685310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4U2"/>
    <dbReference type="GeneID" id="26246409"/>
    <dbReference type="KEGG" id="mbrn:26246409"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
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        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="5">
        <location>
            <begin position="41"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="424" mass="45979" checksum="37D426181FB44D4D" modified="2021-02-10" version="1">MPSLSHPESLPSSGGTSLSSSRPSTPDDGECQHGHDADQVVLVIGGLGFIGSHTTLELLKAGYSVSIVDDLSNSFKVAFNRIRDLAVKHHASRGTKMPSLQLHTLDYRSHSMRSVLDLYSESSWKASETDAQAPHSARRSRISGVIHFAAFKSVSESITHPVQYYQNNVCGLVNLISLLGEHDIRNFVFSSSATVYGCKADLGRPLREEDLVHPESYVDDNGAEVTPASFASLQSPYARTKFFCEAILADIARADSAWRITCLRYFNPIGCDSSGLLGEDPRGTPTNLFPVITQVLTGAREHLDVFGSNWDTRDGTPVRDYVHVSDVARGHVAALAAQAVEPFRTFNLGSGTGTTVAEAVRSLERASQRPIAVRLADRREGDVGSCVASNERACRELGWEAKESVGQCAEDLWNFVSKAQAPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4U8</accession>
    <name>A0A7D5V4U8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540353.2">
        <property type="nucleotide sequence ID" value="XM_014684867.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4U8"/>
    <dbReference type="GeneID" id="26246947"/>
    <dbReference type="KEGG" id="mbrn:26246947"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="535" mass="59766" checksum="5ED2CBDAF5A486FF" modified="2021-02-10" version="1">MEDERARSCIVFISEDQVEKGLVLAKRGQQQLEPVSEKKTLYYFTVSHNDHYSVCEILVSPIKVDHHKNVFFWPVQRYTKCCENASEDELKRLRQIIYDVYVRPVQWSFGDDSNKAVPVSNSPTNGDCEEHPEVGRRYLQETATIITPATREETASRWLSQSPSQSSNATTETDLTDTDSTRPSQNKKRGSDNSLVSTISKKSRPNMKPGFECPFNPTTVITKLLRSLEDLKKATSHQKKVTGNVSNFHVDSSTGFPLLTTNKEREEFANKLYKLDRNNHLTRMRAGDDERHDAADKIAESLREKLPALSGSTYIFHPPAVIAALWNEDYETLCKQLGADNLALQNPTVVKLQYSTEPELYTYAVRLEHSCPLQHGAPDNGKIDFGNLADGKLFSPNTYQHIGCNSIARRQTQQRLDGVNCPVSVSGEPRAGSSSGRSSRSSSNGCPSAISPVTGSQEIDPLDIFRHIGNDTPATHTMERNGSDNFPDIEGLGINPFNVNIFHEIDRLERNATDNFLDIEGLGINPFDVGIFQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V545</accession>
    <name>A0A7D5V545_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">wis4</name>
        <name evidence="15" type="ORF">G6M90_00g102470</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546099.1">
        <property type="nucleotide sequence ID" value="XM_014690613.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240522"/>
    <dbReference type="KEGG" id="mbrn:26240522"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1323"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI73871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1352" mass="153399" checksum="96097E85807A2AAA" modified="2021-02-10" version="1">MSDPSPRAVRFSGGEDELQQERPKPRRPSVVVSPDAVNSSPGSEDEPNAIEGHSEINDLNRYVDAPTHASSLASIPAKTVVNGVGVGSKTQWNNVSDDGTPYANGGRPQRPLAPARTPSNTYNPATSRKPRPSQQTQPFVESMRSSSKTRTRQSESRFRAQERAYIQKLRHDAASGEYFSSYQGMNGNDSDSEGETPNSEGPYDIGPDQETNMFYGSDNLLPTEEDMNDPNNRDRLEWYAMLEAVLTGDVVRQEKKRLIGTSDQQASKTAHRSELWLGVRAKCCGRQLPVQKRMVEEARSTVDRLLDDIVNFEVKGESVAGKPPYEQVQDIVKKIEKCESHYPSWQSLAAEHKTAASPQFHEAYEAIFSWYNTNKMINTELSILKKWVGNEELDFSRTKQRSPAVDGITNDETSFLDRLMKEDGLQSLYDDDERTPQKGMLWPISSIISKAKETLIRNSAPFRKRHLPPYLEELLTLISFPSRLIEEITKTRLEYAKRVKEAAQQNPMMQEQMISQFQLLLKFAIRIKQEYLSIESPEPGWDLPPCIDESFDQVVLEALKYYFKMLNWKLSGNKNSFKEAELLFQEWDFANYIGSHLQGGQIEVAEQFSSLTFKALNRLSETFEKELQVKPKESATDMSKRYKACLDSVRIRQRMLQRFGRMLSDNYEHSSDFSICFPPETMQKFYDQLVASGHFLLQTGVYEKQEKYIIASPELHGKLDDMQAMMAVTSIDRFPDLGEQYLLILRPEGSFHWFGEKVDVPLREQNIDLKRGQARLCATGSQALPEARKAFLDAVDMHLDLRQESRSNIHKVNVRLVEIRRVAYKLSSTFMDSVEVIRKQAEGKDCQELIQTCFVFATEFGQRSLLYMDHNRRQMNNLKLTKLALDWVSFICDDCVASDRKTFRWAVLALEFAMGMTRGKHILTLGDEEYERLRRKVGGCMSLLISHFDIMGARSNLAAQAEKERMEALLGQFRKLDKNRMLDDEEASRCTTEQRLMRLDVVDELRHEKEGERRALGRVLEANNEADRSLAYLSSSATNVTKRWQQGHFVGGGTFGNVYAAMDLDTGLLMAVKEIRLQDPKLIPTIAEQIREEMGVLEVLDHPNIVQYHGIEVHRDRVYIFMEYCSGGSLANLLEHGRIEDEQVITFYALQLLEGLVYLHESGIAHRDIKPENILLNHNGIIKYVDFGAAKVIARQGRTLAADLHATKPNKSMTGTPMYMSPEVIKGENPGRAGSVDIWSLGCVVLEMATGRRPWANLDNEWAIMYNIAQGNPPQLPTADQVSPAGLDFLSKCFIRNPKERPSAVELLQHEWIMAVRSQVVEPMTPSDSSSSAQMTPLTASSSKGSYMPDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V647</accession>
    <name>A0A7D5V647_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anhydro-N-acetylmuramic acid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">anmK</name>
        <name evidence="1" type="ORF">G6M90_00g113410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539764.1">
        <property type="nucleotide sequence ID" value="XM_014684278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V647"/>
    <dbReference type="GeneID" id="26247429"/>
    <dbReference type="KEGG" id="mbrn:26247429"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="444" mass="48451" checksum="26F349E78AF185D8" modified="2021-02-10" version="1">MGSVYDGATGSQSSPLDLVVLGLNSGTSMDGIDCALCRFRQATPDAPMHFELLKYDEVPLEPTIKKRVMAMILHNTTSPEELSEVNVILGKEFAQAVKIFSQRHNVPLSSIDVIGSHGQTIWFASMPEEGNVTSALTMAEGCFLASMTGITTVTDFRVSDQAAGRQGAPLIAFFDSLVLHHPTKLRACQNIGGIANVCFIPPDRDGKLNPEFFDFDTGPGNVFIDAAVRYFTDGQQEYDQNGRMGKAGTVDEEMVDKFLSSFAYFSLDPPKTTGRETFRDTIAHDLIEQGLEKGLSANDVVATITRITAKAIVEHYKRYMPTGYGPLCEIYMCGGGAKNPNITDYLQAAFPAAKVMMLDEAGIPADAKEAITFAWQGMEAIVGRSIPVPDRVATRQPYVLGKISPGKNYRRVMKRGMDFGAGQDELEPVTELVHYVDGKVFSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNJ4</accession>
    <name>A0A7D5YNJ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">cta3_0</name>
        <name evidence="26" type="ORF">G6M90_00g002530</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542829.1">
        <property type="nucleotide sequence ID" value="XM_014687343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNJ4"/>
    <dbReference type="GeneID" id="26244202"/>
    <dbReference type="KEGG" id="mbrn:26244202"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000039">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="326"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="880"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="970"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1004"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="QLI63902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114872" checksum="6EAAC777066DD388" modified="2021-02-10" version="1">MGGKTAQQHALAGHVSGQCNKLLSRPAHSLSVDDVLEELRASPSQGLTGAEAVERLAEYGPNQLKEKKGVQPVAIFLEQIFNAMTLVLILALAASFGIEAWIAGGILGGIICVNIVIGFFQTLQAEKTIDSLRTLGFPTCNVYRDGDTINIQTADVVPGDIVDLNTGDSVPADIRLIEAVNLEADEALLTGEAMPMSKSPKLTFDEDTGPGDRLNVVYSSTTITKGRGRGVVFATGMFTEIGAIASALNSDGKIIVDQQDSRPSPLSYVKQAGRMMRNWIGEFLGLTVGTPLQRKLSQLFVSLFVFAIVCAIVVLGANKFDTRKDVILYAVTTSVGTIPVSLLLVLTVTMAAGTKKMVERHVIVRNLQSLEALGGVTNICSDKTGTITQGRMVVRKAWIPGFGTYSVDTGNQVYNPTAGAVAFTASQPKDISQTHEKQNREQPVAPQDDARNKTSLQWYLSIASLANLATLEKAEDTAEGPGEWKARGAPTEIAIEVFTSRFGWSRVQLSEGEKKKWQHVAEFPFDSDVKKMSVLFRSCQSQQTHVFTKGAVERVLEICDRISFDDAVEPLTETIKSNILDNMVSLAGQGLRVLALAHKPLDRDVSDAEFAHGSSPDRCEFEQNLIFRGLIGIYDPPRSESLPSVKACQGAGIMVHMLTGDHPQTARAIAMEVNILPSEDKIRMLPADMSRTLMMTAQEFDALSDSQIDNLQQLPLVVARCAPSTKVRMIEALHRRGRYVAMTGDGVNDSPSLKRADIGIAMGTGSDVAKESADIVLTDDNFASILNAVEEGRRIFDNIQKFILHVLAANIGFVVSLLTGLAFKDGSDVSVFLLTPVEILWMLMATGAFCETGLGFERAVPDILNRPPQNLKYGVFTREFLLDMVIYGALMACCTIGSFTVVVFGFDNGDLGSDCNNKYSSSCEAVFRARATSYTTMTWIFLLFAWELIDFRRSLFDMPYGFKAWLAHFWSNKFLFFSVIVVFVMVFPTLYIPVINDVVFMHKGISWEWAVVFIAVGVYLAGNEGWKWAKRVYYRRQGVERVDWEGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQE2</accession>
    <name>A0A7D5YQE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986065.1">
        <property type="nucleotide sequence ID" value="XM_066129995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQE2"/>
    <dbReference type="GeneID" id="90967543"/>
    <dbReference type="KEGG" id="mbrn:90967543"/>
    <dbReference type="OrthoDB" id="4947116at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="604" mass="67615" checksum="FCCB6401418C2AF8" modified="2021-02-10" version="1">MADALRPDNETYKFYYEAGYRLWHSLCSSSDTSPLDATSLDIENAFPQHPYFPPQLELDRNSSTVLYATGTSTWETSNGSCNLPPLQIGLTFGVTIACPTAISLQSSRLIDSPNLFDEESKHMLVLTLAWAYVLSARWTEIIPGASTMSYTESVATRDSRDNARNGDGDLIVDLGDITYEAARWWAAILAPEEGWGACIFHNGRVLKSPWSVKLESCRTLALRYNAVPSPLEWHFSASFSTAMAYVLDYAIYHGLQNQSRAAFAAALLLPTRHRISKQVRWPRMHLPRMQRSKPSVEQYLPPWGSNNCQLDRLLALSCNTTGVISLLCSTFIEPDIPCNVCGAWIQGAFAILDTQVAKEPHILAQMLMCRAPNLNFLWLGGILMNVQHYIMKWARPVAFQIDLHSAAWTNSYVSFIQKPVSRTASNATTVQRSDEARLMFLSQADHHSNPPLVPFTPFGSIALKDCILEVQMHVSCPGYHGLRYAGWAWNCRNNTKIAQDPIESSFTPSSKVDDAVAGHTTIHYDNLDRDRDCSESMTRNMFKWLREADGFPVAERAIREHEWISGGWSSEEESAAPEGDGKSTTNRQIGPWICRGITTRCNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YR52</accession>
    <name>A0A7D5YR52_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nonribosomal peptide synthetase dtxS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dtxS1_0</name>
        <name evidence="8" type="ORF">G6M90_00g001820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986132.1">
        <property type="nucleotide sequence ID" value="XM_066129517.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244269"/>
    <dbReference type="KEGG" id="mbrn:26244269"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="585"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1696"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2798"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4327"/>
            <end position="4403"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="5463"/>
            <end position="5539"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="6978"/>
            <end position="7054"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="8512"/>
            <end position="8588"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="9596"/>
            <end position="9672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1264"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="5340"/>
            <end position="5385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1264"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="5349"/>
            <end position="5374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="5375"/>
            <end position="5385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="10229" mass="1129436" checksum="0EEA302A0B6154DB" modified="2021-02-10" version="1">[encoded data, 10229 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRF0</accession>
    <name>A0A7D5YRF0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ALG8</name>
        <name evidence="13" type="ORF">G6M90_00g056990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544285.1">
        <property type="nucleotide sequence ID" value="XM_014688799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRF0"/>
    <dbReference type="GeneID" id="26242697"/>
    <dbReference type="KEGG" id="mbrn:26242697"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="503" mass="56813" checksum="26326B613968227A" modified="2021-02-10" version="1">MSESYPSLTQCAVVAAAFKVLLFPAYKSTDFEVHRNWLAITNSLSLSEWYYEKTSEWTLDYPPFFAYFEWVLAHLARLVDPAMVKVYNLNHESWQTVYFQRATVIATELLLVYALQLFIDSTLLPSRRAAQVAALSVMLSPGLLLIDHIHFQYNGFMYGILLWSLVLARSKSTLLQSGLVFAALLCFKHIYLYLAPAYFVFLLRTYCLSTKSYFQIKFLNCIKLGLGILSIFAAAFGPFALMGQIPQLLSRLFPFSRGLCHAYWAPNVWALYSLADRVLIHLAPRLGLDVKSEALQSVTRGLVGDTAFAVLPEISPRVCFVLTLLFQGLPLLKLFLTSNPSWESFVGAVTLCGYASFLFGWHVHEKAILLVIIPFSLIALRDRRHLGAFRPLAVAGHVSLFPLLFTPAEFPVKTIYTVFWLVLFLMSFDRLAPASSKPRVFLLDRFSTLYIAVSIPLIAYTSLLHHVIFGKSYEFLPLMFTSSYAAIGVVGSWVGYMVVYFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRL6</accession>
    <name>A0A7D5YRL6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">White collar 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">wc-1_1</name>
        <name evidence="17" type="ORF">G6M90_00g042230</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547561.1">
        <property type="nucleotide sequence ID" value="XM_014692075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRL6"/>
    <dbReference type="GeneID" id="26240124"/>
    <dbReference type="KEGG" id="mbrn:26240124"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="546"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="683"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="282"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="789"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="876"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="906"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="949"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="995"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI66822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109139" checksum="799908F0168DB4A0" modified="2021-02-10" version="1">MDDYYKTNALPPQEGQRQMPQQHEGQQQQQQQPSGNVIDMINRSSVSGSQMSLQPPPSAMPQLIQNQPMISGDSLDDIIRNNHTEMHRRKSMPHAYGSPLMQDENPRRMSSIAASEDVMAFDPSQHDLGNFQFSQPVGSSFHGINPSLEMTDQMGGFVTDATDYSGISADLIGPMNPPPFGNVELSQMPNEPSLSLFPPSPVPGAGSGARPMNSGFVSGQMPNLSATFGTEPAPSSSTLTATSNTLPGSIDDHPDGMMHISTSQLNAVNPPASRVPETMVANPVSSNLGQPLPHSLSRHISSESGITQPSSTSGPTTPATTSTPRESKEKTIYSKSGFDMLKALWLVATRKDPKIHLGAVDMSCAFVVCDVTMNDCPIIYVSDNFQNLTGYSRHEIVGQNCRFLQAPDGKVEAGSKREFVDDGAVYNLKNMIREGREVQQSLINYRKGGKPFLNLLTMIPIPWDTDDIRYFIGFQIDLVECPDAISGQELGGVKVNYKHNDIGQYIWTPPASSQWQPENGQTLGVDDVSTLLQQFSPKGLVSDWHKQSWDKMLLENTDDVVHVLSLKGLFLYLSPSSKRVLEYDAIDLVGNSLSSVCHPSDIVPVTRELKDATASAQVNIVFRIRRKQSGYTWFESHGSLFVEQGKGRKCLILVGRKRPVFALSRKNLESNGGIGDSELWTKLSTSGMFLFVSSNVRSLLDLQPESLVGTSIQELMRKESRLDFGRQIEAARRGKIVSCEHEVQNRRGQGLRALTILYPGDAPEGQKPSFLLAQTKLVKANRVVLATATSNSQAASTSSQSNAVPELHSGAGQVSQPPGGGLPLGTQDAALAALAAEDNIFDELRTTKCSSWQFELRQMEKVNRILAEELGGLLSNKKKRKRRKGVGNMTGRVSPRNSFRGGNNGNGDSQSKKSPSPIHSSPLHKEFASENPTSQAVVAKGDTDETDMLNPSQLGNHVSSEASESNLVQRQMMAMPPPSQPSLSSGAAGSGMTSIREEHEASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRW9</accession>
    <name>A0A7D5YRW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAGA complex subunit spt20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spt20</name>
        <name evidence="3" type="ORF">G6M90_00g033340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543264.1">
        <property type="nucleotide sequence ID" value="XM_014687778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRW9"/>
    <dbReference type="GeneID" id="26244065"/>
    <dbReference type="KEGG" id="mbrn:26244065"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="123"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
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        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
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        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
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        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
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        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115029" checksum="E29A45E0B4AAFE97" modified="2021-02-10" version="1">MLPTSPVVQQNGAAKIKRPVPPGIQTNGIASSNSSPSPSMSAKKPPTSAKQAPNSASDRSITASTVRPVNRARRENSSQAAGRNSRNSAGMRTGSFSVDAGAKDYGPPPYVVTSQYILSKYSGKPPSLVVHLHATHFRFDGQDGMFPYKSPMGKFIEHLRARTLPHDILEYLIEAKVPFYDGCLIVQIHDHKSLAQTTKAVTKASRTSDAVLPSSIHNYNQCLTPSPYVPFPKEEQVTENGIASKDTDNSKQSPEEGKDNESVTAPTQPSESTTTKEAPKPKIFTAVLHPTPESLQSDLKIKATTPKGDGKGVNDTPSLAPPSTPLSLVPPTPTASSMPPPANKRQKKERMELDSSTIYAAEGQILLATTAPLILEPTRNPEETILLLEAMAHPKHSEPPPQPKTRKRTVAEMAADEAAAADQERYMLVLDDRLSGNTSGAQGSSATDGEAQTNAAAFEPRFERFKVIEDIKRDHAEKKEQEKIKQQENDRRLQLQRQEQLLQAQRQQAEAERQRREAVLKENQMRQEAQRQQLAARSTAAAAAQSQQQQQNQQTAQKQQQQQQQQQQQQQQQQQQQQQQQQQQQKPQSQPQPQPQQQPPQQQQQPQPQQTTQHAHPAQNGITGNISNGVPAGGQSAMANNMQGAAQPRFPAQMSQAAAASSPVIRQGTPLSSPMVGSVPMQQTNSNIATSPPRPPSAVQNGQMSVPMAHNMSARGSQQSHHSGTPRMPNSTPNMPHGTPINRQTVAATPRMTHASPPPNMVAQNSQMGQAMMMNQQGINQHNPQIFAQMAAQQRAIAQQQQQQMAAMQNGGANAGLNPQGMTPQQQQVMQMMQRQMMLQQQQQQAQQQQHQQQQQGGMMTPQQQQFAQQYAQLQQNMQGNQTRQMSAQVQAQLQQMARMGQINNPMQRQVSGQMMNGSNANMQAFAAMQMQQAQQQQQQQHHPQQQGQPQPQPIGANPIQAQIQINARQIYSRLMQGAVAKFGSAENVPQDTLDKMKQSSLLQAQQMLQQSMVQRRAQQQQMMLQQQQQQAAMQGMGGMMGHPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSM5</accession>
    <name>A0A7D5YSM5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein regulatory factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">etfrf1</name>
        <name evidence="2" type="ORF">G6M90_00g045320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986460.1">
        <property type="nucleotide sequence ID" value="XM_066130368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSM5"/>
    <dbReference type="GeneID" id="90967691"/>
    <dbReference type="KEGG" id="mbrn:90967691"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="87" mass="10489" checksum="D52B1901A5D27ECB" modified="2021-02-10" version="1">MAQPNPELRRQVIAIYKELLYLGREYPLGYRYFQPRLHKAFMSRAAERSEDKIRAGIAQAEYVKKEIEALYYLKRYRTLRKRYDVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSU9</accession>
    <name>A0A7D5YSU9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lip2</name>
        <name evidence="2" type="ORF">G6M90_00g032180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543153.1">
        <property type="nucleotide sequence ID" value="XM_014687667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSU9"/>
    <dbReference type="GeneID" id="26243954"/>
    <dbReference type="KEGG" id="mbrn:26243954"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF584">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="91"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="339" mass="38248" checksum="9E99526E6DFB46C2" modified="2021-02-10" version="1">MMLSVFRIITTWYRPLLVALFNPSIPFHLRWRTLLLQPITLLTYSINALPYFFSRPFTVEYLPIFPSHAIRAIVFKHPGTGKGRSLRPLHVEIHGGSFIGGLAESNARFDERLAKETGAVVVSITYRFAPEHTFPCAIDDVDAAIKWIQEHAESRWGADATLMTVSGFSCGGNLAMAATQQRNCQAPARTSFKAAVTFYGALDLRLEPGKKPKPANYPKSDPLQFLLPLFDAYAQPARAKHMDDPRLNPVLARTETLPERVLLVVAAIDILYAEQMAFKERINKEAKRDVVETFVAQDGFHGYLEVPDAILKKEVKDEAFTRAVEFLKRTYSLHGWDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSX6</accession>
    <name>A0A7D5YSX6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Psma6</name>
        <name evidence="7" type="ORF">G6M90_00g011350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549387.1">
        <property type="nucleotide sequence ID" value="XM_014693901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSX6"/>
    <dbReference type="GeneID" id="26238831"/>
    <dbReference type="KEGG" id="mbrn:26238831"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="253" mass="27775" checksum="928853E20F709759" modified="2021-02-10" version="1">MSASAYDRHITIFSDNGRLYQVEYAFKAITAANIMSVGVRGKDCAVVLSQKKVPDKLIDPTSVSHIFQISPSVGCVITGSIADARAFAQRAQGEAAEFRYKFGYEMPADVLAKRLANISQVYTQRAYMRPYGVATTIISLDSEFGPQLYKCDPAGYYIGYKGTAAGPKQQEALNHLEKKLRNKDCAEGTWEDVVELAITTLSTVLSMDFKKGEIEIGICGGPRTDGKEGTNAAFRMLTEDEIDERLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT26</accession>
    <name>A0A7D5YT26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g068640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987076.1">
        <property type="nucleotide sequence ID" value="XM_066130883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT26"/>
    <dbReference type="GeneID" id="90967902"/>
    <dbReference type="KEGG" id="mbrn:90967902"/>
    <dbReference type="OrthoDB" id="1421156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="93" mass="10840" checksum="D5622AD205C125FE" modified="2021-02-10" version="1">MGSPTREMFAARLLKFEEAYLTDYIEEVGYIKTTWLDPYKEKLVKAWVDQHLHFDNVVTSRVEGIHGLLKSHLEVSTLDLFEAWRTIKLVSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTE0</accession>
    <name>A0A7D5YTE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-3-methyladenine glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MAG1</name>
        <name evidence="6" type="ORF">G6M90_00g076530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545450.1">
        <property type="nucleotide sequence ID" value="XM_014689964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTE0"/>
    <dbReference type="GeneID" id="26241483"/>
    <dbReference type="KEGG" id="mbrn:26241483"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="181"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="360" mass="39576" checksum="68C996C95CCB6D73" modified="2021-02-10" version="1">MAATRRSSRLSAQSDAKPSSPQPEDQTANSTQNNRKRKASTSKATAPVTPTKRRTERIQPVPPSTPTPSAAGAIAEPAASTKPRTHPTIARLADPLATNATLLSPETSRVVAFKDIDLGSPSKKPGTRITTENLLDVACAHLISVDERMRPLVERNHCKVFSPEGLAEKIDPFESLSSGIISQQVSGAAARSIKAKFLALFDTRDRTTRFPHPSEVAPVPVETLRTAGLSQRKAEYIKGLAEKFANGELSTEMLHDAPYEELVEKLIAVRGLGRWSVEMFACFGLKRMDVFSVGDLGVQRGMAAFVGRDVAKLKSKGGKWKYMSEREMLDISEKFAPYRSLFMWLMWRVEDSYTDVSTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTL6</accession>
    <name>A0A7D5YTL6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g055470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544142.1">
        <property type="nucleotide sequence ID" value="XM_014688656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTL6"/>
    <dbReference type="GeneID" id="26242554"/>
    <dbReference type="KEGG" id="mbrn:26242554"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="398" mass="43335" checksum="013DCD7806D20A84" modified="2021-02-10" version="1">MAYASTHPSVLSVVIEVEFLVAVEKDGHKYNNTAAAGNDTEGTASQIHKWACPSQADDPSMDVLHQCKAVLSRDHANVIIRHNETHLTERSWQSARFDSWILQPCHRGSSASSGSPTNYDWSGVKLRSPLMPDTQLTGDPSPALRCVETLRRAILIRVDASCRLSVSLRPGSNFTPVQAKKLATLVWLTERDLLVPLRHLGRDVAAVACPRPVTTASLAAISRHPQTVDAAEPLDPLLEGIMNSHLPTGLGDAAARSCLQRLWACPDLARLSGALRDRHRGPLAFALYVYDDDDDTEDSGASCCAVASFRCAPWHPRRGLDVSPLWTDLVLALGRATILAPERFKSLVAEIDDVNCASRQGDAHGASHRTRLMKALGTEDARCAEWERIVADCRNGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTS9</accession>
    <name>A0A7D5YTS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N amino acid transport system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mtr_3</name>
        <name evidence="8" type="ORF">G6M90_00g064780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986774.1">
        <property type="nucleotide sequence ID" value="XM_066130785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTS9"/>
    <dbReference type="GeneID" id="26247102"/>
    <dbReference type="KEGG" id="mbrn:26247102"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF683">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="472" mass="49748" checksum="D1441F903EB32A57" modified="2021-02-10" version="1">MSSKSGSSGLEGEERHLSVVGGEHLGSDGDAGVRDAVFGNLTEKGPNYRNVGWVGTVALMMKTQIGLGVLSIPATFDTLGLIPGLICLLTIAGITTWSDHIVGVFKRRHPEVYGIDDAGGLMFGRIGREAFGAAFCVYWIFVAGSGMLGISISLNAMSSHGACTAVFVAVAAIIGFILSSIRTLGRISWLAWIGLTGILVSIVLVTIAVGVQDRPAAAPQQGPWVSGFELFKTPSFTSAVSAISSIVFAYAGTPAFFAIAAEMREPRHYTRCLLICQAGVTVTYVSIGAVVYYFCGSYVASPALGSAGAVVKRIAYGLALPGLVATTTIVIHFPAKYAFVRILRGSRHLTANNLVHWATWLSCTLVTTVIAYLIASGIPVFGGLVSLIGALLGTLMSFQPMGCMWLYDNWSKGKQDRTVKWVLMVIFSVFVVVSGTFLMITGTYGSVVGIIDSYKKSGGSGAWTCADNSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUC0</accession>
    <name>A0A7D5YUC0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alkaline protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alp1_0</name>
        <name evidence="10" type="ORF">G6M90_00g028410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986066.1">
        <property type="nucleotide sequence ID" value="XM_066130010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUC0"/>
    <dbReference type="GeneID" id="26245957"/>
    <dbReference type="KEGG" id="mbrn:26245957"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028810446" evidence="8">
        <location>
            <begin position="22"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="189"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI65964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="469" mass="48789" checksum="B51585BC06BAE95B" modified="2021-02-10" version="1">MTSIKNMVLGAVLLWAQLIAAFPTPIGGDGGLLSLLGLGSSRNGDKNASPTPAKSNVKAKSRIVPNSYIVVYKNTTSAADVKAMTASVSSQLKKRNLNKRGFEGQPLSTNVRSFQINNWHAMNFEAEESMALEVGEYDGVDYVENNTWFSTQELVEQTNAPVGLQRLSEAAPVGEQAKKGSYVYDSSAGNGTTAYVVDSGCRTTHRDFQGRATTIANFVKGERATDANGHGTHVACTIAGARFGVAKLATVKCVKVMNAKGQGTNADIIAGLQSVVEDVNKTKPQAATMNMSLGGGRSKALDMAINNVFKAGVLPVVAAGNENQNAKNVSPAAAPNAVTVGAVNATTDQKAGFSNFGPSVDINAPGVDVQSCGIESDSDVSTKSGTSMASPHVAGLANYLMRLENVSDPAKVTALLKNLSKDTDATVEGGRRDTTPLIANNGNQKDKNTFLDENGPVKGGTQGNGAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUF9</accession>
    <name>A0A7D5YUF9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sexual differentiation process protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">isp4_3</name>
        <name evidence="11" type="ORF">G6M90_00g010090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549508.1">
        <property type="nucleotide sequence ID" value="XM_014694022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUF9"/>
    <dbReference type="GeneID" id="26238952"/>
    <dbReference type="KEGG" id="mbrn:26238952"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="881" mass="100341" checksum="AF4812ADAD84A2B0" modified="2021-02-10" version="1">MAEDEKRAAVAEATEATEDAARRPSASPTEKSEPNSEPFSYDEDDSFARQGDQPRTPTAIEHDLNVTEDDLLEAKELASQYTLEEVRDIMIRVRRIHEKDPNFPTTVIEKVKTFLDNDDIFENPDQHQHLIQEMKLEAALVTSNSPYSEVRAVVSNKDDPKTPCSTIRSWAIGLIFSVLLAFINQLFDIRQPAIRVMANVAQLLAYPIGKAAERWLPDKGFTMFGIRHTLNPGPFSKKEHMLITIMANVAYNTPYTNYIIWVQYLPQYFDQPYASHFAYQLLIALATNFIGYGIAGICRRFLVYPSYCVWPASLVTIALNSAFHTEMNPPVGGPFRSIWRISRIKFFYLMFAAMFVWFWFPNYIWVSLSKFNWISWIAPGHRDLNIVTGINNGLGLNPFPTWDWNVLLWDSADPLMVPFFSTLNRFIGVFASFWVVLIFWYKNVYNTGYLPINTNRVFDRFAQLYNITKATDDHGLFNAEKYESYSPPYLGAGNVVIYMFFFAIYTSTLTYAALYHRHEIAMGFKALFYSLRLKKKPVKEERVLDVHNRLMRAYPEVPEWWYMACLAIAIAFGISGIVGWDTHTSPGVVFWGLALCVIFVIPVGIIKAMTGIEVTLNVLAEFVGGSWVDGNALAMNYFKSFGYVTCAHAIWFCNDLKLAHYVKIPPRQTFVAQMVATFLSTIVCIGVLNFQMNNINNVCTPEAQYKLTCPGVNTFFTASVLWGTVGPQKIFGHRGQYSQTLIGFPLGVVIVVLIWALNKKFPKWTWARQLHPVVILYGGIVWAPYNMSYVWPSVPIAYFSWIYLKTRFLGLWSKYNFVLSAAWSCGIAISGIIIFFSLQYTETDFDWWGNNVSEMGCEGNACALKTLGPGEWFGPGPGKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUR1</accession>
    <name>A0A7D5YUR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g078610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545247.1">
        <property type="nucleotide sequence ID" value="XM_014689761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUR1"/>
    <dbReference type="GeneID" id="26241280"/>
    <dbReference type="KEGG" id="mbrn:26241280"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="246" mass="26847" checksum="1EC45D4A7E04F0BA" modified="2021-02-10" version="1">MPRPTKLIIVCCHGIWLGGPSKGHNEAEWLLADFQHGETPTFIAHIKAGLQCLADDRGHAVLAFSGAPTRRETTLSEAQSYANVAMQNACFGLLDPPVTDADMMLEERALDSYHNVLFSLSLFYARFQRWPRHVVVVSHAFKRPRMLEGHCAAIGFPPDRVSFVGVDPPSLEGKPGVVAGVAEAEADWGRDPHGKGQRLAAKRARRNVWGAWQGVFEEGTEDADKGGLQTAGEGASEVIVDGERPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVX5</accession>
    <name>A0A7D5YVX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g099250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546421.1">
        <property type="nucleotide sequence ID" value="XM_014690935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVX5"/>
    <dbReference type="GeneID" id="26240844"/>
    <dbReference type="KEGG" id="mbrn:26240844"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="130" mass="13164" checksum="FC4625CD1BC45460" modified="2021-02-10" version="1">MAAEVSHGRGGAGNINPDKTEYVDGEVVRAGIEGSHGDGAYSAGRGGAGNIGDVGSAPAARKDKDVVPESAYRASQDNQDYHTGRGGAGNEHVANGHGKKAAADRTGEDVAAPVGLADKLKQKLFGVIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXM4</accession>
    <name>A0A7D5YXM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547832.1">
        <property type="nucleotide sequence ID" value="XM_014692346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXM4"/>
    <dbReference type="GeneID" id="26237276"/>
    <dbReference type="KEGG" id="mbrn:26237276"/>
    <dbReference type="OrthoDB" id="4938159at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="514" mass="57111" checksum="CE31DCB58FB3C073" modified="2021-02-10" version="1">MPTLRSQQRRDTKGQKRGVASSPDEITEDRQSTRPLKKQKRGHSYFPPPKFWDGLSTIPLTRNAIRELDRRNQLSSHPPSRIQTLHTPRQPSTLQRFARQGGPDLSAIRGCQFPIDLGGNMSSSQSSLGRRKRGSQSPVKRTSQSSSKTNATPNTTSTRSTGPYDRAFQQNLIDHNIFPDGYEYPDGALPPEPENMNDILHAMAQPRPSLSPPRFSNDDFRRFKRADTHAFKEREITTNVIPLIEGTIADSKCVAGDVPFTNLDDLTDGTIVSGKPDLYHGARPEQLDIRVRREQSRKINPSPQSDLPILANFFLEAKGPDGTLSVASRQSCYNGALGARGMLSLQSYGQPEPEYDNKAYTISSIYHGGTLKMYTSHPIPPRTPEGKPGFVTTQIKTWGLTGDADTFRQGASAFRNARDWAKEQRDNAIQQANERAKRVASFTASGLGLDLADEGSGEDTITTSQETVLRPHSHSHKSRSYDSDTSADELSLDIGDWSVAKRNKSRSRSPRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXV0</accession>
    <name>A0A7D5YXV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547340.1">
        <property type="nucleotide sequence ID" value="XM_014691854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXV0"/>
    <dbReference type="GeneID" id="26239903"/>
    <dbReference type="KEGG" id="mbrn:26239903"/>
    <dbReference type="OrthoDB" id="4928264at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="193" mass="22207" checksum="FC4422914E08F62C" modified="2021-02-10" version="1">MDKEDFFRQKSKSAEIQIKRLNREVDSLKTQLQRKTKTIDAQERRLDTLADALKEAEQRTESSKHLNQKLQNSQHESKRYRTALAAAFKLIDDLKDKTTIAELLAQTDQQLLGGAPKQEPDTTAAASPEDSSDEYYIRKPVTRKYPEGGIATPRRPVKREREGDWSSEDSDERPLAKARKLDDRILRNITPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXY6</accession>
    <name>A0A7D5YXY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g005850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549919.1">
        <property type="nucleotide sequence ID" value="XM_014694433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXY6"/>
    <dbReference type="GeneID" id="26239363"/>
    <dbReference type="KEGG" id="mbrn:26239363"/>
    <dbReference type="OrthoDB" id="4935807at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37456" checksum="432DCB2C1DA908ED" modified="2021-02-10" version="1">MAPQQETGRLPTPFKRASSESNIELEHLLRLMPASRRSKTVFHFNDRKSCPMDIVQRPKADVEFLAEELCVPSLNDIHDLLWLAGRPMPPRPLTYQLTASRTIAVVEDINLHLIWEPGRIFLKPIPRFLLNAAFWTKHLASLIQHESDYRIAASNHLLPADVDWESWRQTSWELLENSPCNMTRVNKRYRYGELRLSRLNKISRWRSLTCSGDGLVGLMRGYKFGFATYGQLLEACLFPVVTATAYILLVLTAMQVGLSTDYLKDNFAFQQASWGFTVFSILAPLILIVLSFVLVFLYVVFNYRSTKAFNQRRMQFYDNLGRNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY99</accession>
    <name>A0A7D5YY99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">sed3_1</name>
        <name evidence="18" type="ORF">G6M90_00g097350</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987547.1">
        <property type="nucleotide sequence ID" value="XM_066131528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY99"/>
    <dbReference type="GeneID" id="26241029"/>
    <dbReference type="KEGG" id="mbrn:26241029"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF10">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028989309" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="20"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="206"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI72801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="569" mass="60470" checksum="53190FFEC89FCFA6" modified="2021-02-10" version="1">MLLLGTLGALVAFSSPTVAIPASKVSIVQKISNAPQGWTKHGAQVDKTTSMVKLRFHLTQPRISEFHDLAMKIATPGNELYGKHLSKEEADKFLAPKPESVQAVQEWLRGEGLGDHAEVDGSGDNILVHASVADAEKLLHAEYDPFVAQDSGEVIMRTLQYSLPDNLKQHIDVVQPTTYFGVKSVRLTQISLQNNNTPSTQASCKNSNPACLSDLYSYGSAKAYSNGRMGIAGFIGQFASKSDLATFMSKQATQNNTDQSFSCVSINDGGCPENNPGVEANLDTQYARAITEKIPNVFYSTGGSPPTNGSVPDNEPYLEFLNFFLGLSDEDLPNTISISYGDVEYTVPNDYATKCCDLFCKLGARGVSVLVSSGDSGVGGSCPGGKFETSFPAACPWVTTVGGTDGTGPEKAWSGSGGGFSEIFAQPSYQADTVHQWLKNDQTHQSQDPYFNSSGRAYPDVSALATNYPIVVNGSTFGVMGTSASAPVFASIIQLISSDRLSNGKKPLGFLNPWLYSSAASALTDITNGSNSGCANINGKGFQAVQGWDPVTGLGTPNFEKLLKVSQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ08</accession>
    <name>A0A7D5YZ08_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hercynylcysteine sulfoxide lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">egt-2</name>
        <name evidence="8" type="ORF">G6M90_00g010650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549454.1">
        <property type="nucleotide sequence ID" value="XM_014693968.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238898"/>
    <dbReference type="KEGG" id="mbrn:26238898"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="598"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="685"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1405" mass="155729" checksum="1D43AF3AE98C2C86" modified="2021-02-10" version="1">MPTQHVKPGTEEHLGDVANALLKARKVVVVTGAGISTNSGIPDFRSENGLYSLIQAQFDAASRQARQDEHDDHDEHEEAADNARPTKRRKTSMDAINEPDWITVKVGPDDCQDALQDGPSLPQHTDRPELLEDSAVTAATAATQIVVGTKFRTPQSKTETRSSPDLNSSPPSSPSAEFMISPSTVRSHTHRRLTDAALPLSSSPLSSPPPVLFDPFDTVSPSEASSGRRSSTSLSEVDETDSPPNSLPSSQNSAGSRSALPNMKGKDLFDANIWSDPIRTSVFYTFATSLRQKIRHAEPTTSHRFISHLRDRGKLVRCYTQNIDQIEEKVGLSTRLQDGPGSRGRFSRRSTANMTQLNKMVEEAKSASSDKLASETSSLSDAPADSSEQSQPSSSDENNIPATDREPRSDNQANAIPKVRRELPRSGVECVFLHGSLDLLRCFLCGKVCSWDHDNRESETLSGQQPECPHCVGATAARQERGKRALGVGKLRPDIVLYGEEHPSSHLISPIITHDLSLYPDMLLILGTSLRVHGLKVMVREFAKAVHCKGGKVVFVNFTKPPDSIWGDIIDYWVQWDCDAWVTDLQARIPKLWQELEPARPRRKRESSGTSEDSAKEEKKKPPPANPVALRDTKVTGAYWTFKVLSELHRITGNLQPENVPARRASLPAGITAAGIVAEVFPHAPTNKVQKETKARQKGSRKSAPGALEKGQRRSSTLNPNHGRSRKKAQAMVSSQVPDHVPEPTTSPALTSVEPCSTNSILSSVKENARVRKRKKVDGEEIPAPKVGRRRGGSSRHKAKKDDLKLPPLQPLGTNRPALLYGKPQPLEPKSPPSGPLTSLSPNLRSAKTFQRHNAFFLDELLVGLHSAPHGHPFQNYSENVPPTQAGTKEEANAAFALAGLRTSPVMARTMPRKQIEVTAPIYRRVLAALIFNALHTCDYKRLFRSQTTVVMGHQDVLALRAKSAESPRPFGSEWKREFPFDPEWHNLNHGSFGTYPKHIRDRLRAYQDQAEARPDPFIFYEQPKRIDAAREELARLVHAPLDTVVFVGNATDGVNTVLRNLAWAEDGKDVILSFSTIYEACGKAADYLAEYFEGKLEHRGIAITYPLEDEEIIRAFRTTVKEIQDEGKRAKVCIFDVVSSRPGVAFPWMDMVKACKELGIISLVDGAQGIGMVHLDLTAADPDFFVSNCHKWLHVPRGCAVFYAPIRNQHLLRTTLATSHGFIPKLVQRTTPMPPSAKSAYVNNFEFVGTKDNGPYMCVKDAIEWRRDVCGGEDKIVSYLWDLNKKGIKLVADALGTTYLDNSKGTMTNCAMGNVSLPVWVGERGEGAKETDIVVPEEDRDTVFQWITETLVRDYRTFMLRFIMGNRYWIRISAQIYLDLADYEFAAKALGDICERIGKREYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ73</accession>
    <name>A0A7D5YZ73_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRF1</name>
        <name evidence="6" type="ORF">G6M90_00g043700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986161.1">
        <property type="nucleotide sequence ID" value="XM_066130331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ73"/>
    <dbReference type="GeneID" id="26240267"/>
    <dbReference type="KEGG" id="mbrn:26240267"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="206" mass="23223" checksum="2DADE2AA8A635DB5" modified="2021-02-10" version="1">MATAGRAPASIGNDGTATNPRGIPNAPFVDRVEDYVATREEVEPTLRSFQEMISKYQFMEMNLQRRMAGLKDKIPEIQKTLDTVRFLKLRKDETEPIETTFELNETLYSRANVPATSEVYIWLGANVMLSYTTDEAETLLSSKLATAKTSLSHCEEDLDFLREQITTMEVATARVYNWEVVQKRKDKSGEEVTKGQSGEKTGPSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZD8</accession>
    <name>A0A7D5YZD8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g036140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547007.1">
        <property type="nucleotide sequence ID" value="XM_014691521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZD8"/>
    <dbReference type="GeneID" id="26239570"/>
    <dbReference type="KEGG" id="mbrn:26239570"/>
    <dbReference type="OrthoDB" id="5236024at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="609" mass="68889" checksum="857DCF05259065C8" modified="2021-02-10" version="1">MVSTRRSAAARADYDSIYDFESPDKTKNLQTKRRGLARKAASHITNMRGLEKRNREETEPDPPVVKRPTLKRPGRRQTSKAMIEDDVPQDPNFFKNINDSAAGKTKAKRVTIVVPEDDAAAEEQLLQESQQREGQVLAEEKEQSDPSSYRDSAESSDDDDESHEEVDGEKDVGVVGEGDDQGEEAEDSDGEDSSSDDDVREVTSSAVAPDSASRTSNLEHIAGKAVISTNIGYIEPEPPDRSASTYYLNCGGLNEMINAMGKQGWMGTEGEWADQLLQIEKESKTESEAIKADNCTKLFHEIIALWQICKDMPKAPSLNSQAQYLHEHSQSIQKNLKVVRTLTKQVKIEASKSIPAKGSSRQIRNARYKKKDVLTWIQGKLMPALVLALKEALLLGGYSRLKSKPETISIKNGQFMACTLQFALRIVGFIDQLYDVVLTHLKSQEKNENTVRSMRDRTRMAFANHVRVLEPRILLGMNELKRLAEAPILNAELAEQSRQLREAQEERDQIIKEKNDEQMRLFVASTQRTLEDTSKPRDEYYDRHGWRLWEDEVLLGVIRKTRSPNLVLLSRQVPGRSLQEVTNRVAELRESMRAKYEAASILPPKWCHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0J3</accession>
    <name>A0A7D5Z0J3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinol-cytochrome-c reductase cytochrome c1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g044970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547826.1">
        <property type="nucleotide sequence ID" value="XM_014692340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0J3"/>
    <dbReference type="GeneID" id="26240389"/>
    <dbReference type="KEGG" id="mbrn:26240389"/>
    <dbReference type="OrthoDB" id="4949679at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45617" checksum="5A8F5239ED29EC55" modified="2021-02-10" version="1">MGQKNPPPDERVVYLALKNLFKGQNAQVRKSKTVAKLIKGSNKEDAVANLLREHDFDTICTMAGRLLSAKIFESTLKAKVHFPELFDSSPAQSAEKEASEAEAARNEANAIKDATQNRYKEIQSDDPQHVDAAHADDAEGKQAEFTETPTVSKHTAAVKQHMVHMPSLFPLYLPLSVQHKLFVYLQGLLERVCYTYGTQAMPEVLQGRGWDCPEAVELNRWTDEFSKRTDIFRKKPDVGKPINQLFQSLANIRHTAVHRIRLSAKGIEKYLSDAELFVTLIGDTVHLETIDKLRRETLATMEELERNKHLLQVRFGEELRNIADQRAQLDSAERSVIAEILKEDSEYQILAGKHVEEAIAPSEASFSTAINAVEEKGAIDDDTDSTNEYCHDDGHHEDEWGDIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0N3</accession>
    <name>A0A7D5Z0N3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="10">DOHH</shortName>
            <ecNumber evidence="10">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">LIA1</name>
        <name evidence="13" type="ORF">G6M90_00g022310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="10"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548323.1">
        <property type="nucleotide sequence ID" value="XM_014692837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0N3"/>
    <dbReference type="GeneID" id="26237767"/>
    <dbReference type="KEGG" id="mbrn:26237767"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="34888" checksum="0555DC525639F127" modified="2021-02-10" version="1">MADATVPSLRESLCSEATPLPVRFRALFSLKHVARTGEPAAAVAAIEAIAAAFASPSALLKHELAYCLGQTANDAAIQPLRDVLSDLKEDPMCRHEAAEALGALGKPDNLELLKYFRDREGEDVVITETCEIAIDRIEWENSETRKQEKLRQSDFASIDPAPPLPESEKNVEQLGKQLMDTTQPLFMRYRAMFALRDLASPPDCATAVPAVLALAKGFADSSALFRHEIAFVFGQLSHPASIPALTAALSNSEEASMVRHEAAEALGSLGEEEGVEETLKRFLHDKEKVVRESVIVALDMAEYEQSGNAEYALIPEAASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z113</accession>
    <name>A0A7D5Z113_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Solute carrier family 25 member 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g045280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544688.1">
        <property type="nucleotide sequence ID" value="XM_014689202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z113"/>
    <dbReference type="GeneID" id="26242029"/>
    <dbReference type="KEGG" id="mbrn:26242029"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF26">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="181"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI68083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51138" checksum="365373B94B88FF02" modified="2021-02-10" version="1">MPSRNDAAPPWVPPTWSPEPSMGVLPVITNPEDYPDRAPRSNAATAASAAGVRALSAQLVAFYFRAPAKAFFRTRVDYLAYARTVHHQQLKSMLDAVAKDGSASRMRVFLQHTWIWMRSTTPGVLTSAIKQQGWSVIPHQILPPLIANVGVGAVLYTSYLHILGHLHEESAKATKRVYPPPSPTHTFTAGFLAGGLQSVVAAPLDALQARYDHHDLMPSDGSSRPRSMWTFGAEKLREIGLRGIFAGWGLSFAKDSLGSAVFFSMFEYVKAQGYYRFVTWYYGGLGQDIVDFLAMKRPSRQDGDSQVTVIRPHYAIEPMFLFIAGFSASFSQQLLLHPLTHFQVKHWDHLEDLDEKAARYRAARAANPDRPRRPWRMLRAYYHAYQETWAGCTAEAAAEGQGLARWLYRGFWWNTIRQVPSTSAGLIIFELIRRKYGYGADEVRITKDGYDILLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z185</accession>
    <name>A0A7D5Z185_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase RNF167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">Rnf167</name>
        <name evidence="5" type="ORF">G6M90_00g059050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544478.1">
        <property type="nucleotide sequence ID" value="XM_014688992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z185"/>
    <dbReference type="GeneID" id="26242890"/>
    <dbReference type="KEGG" id="mbrn:26242890"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="436" mass="47023" checksum="A1644279CA6CEE5A" modified="2021-02-10" version="1">MAVIDQILGEAALLVARQVSDVPTATPSPTESPTSSVTPPATTSPAKNDNSGNGGSSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNARNRARVTNEEGEPITLETVHRPRRRREKKLMTMDEVNEKFPMMKYKTWVSERAREGLPTAGGVSVPPSRANSIRDADGVLPDVAIVKSHVSTEAHTIDESEFATAADVNKRDDEKKAKPESEQAGETAQTSSAQEDGPVPLRRMSTEEDDDEHIDAALPPECLTAPGDSCAICIDTLEDDDDVRGLTCGHAFHAVCVDPWLTSRRACCPLCKADYYTPKPRPNQEGDASANNGNGLDPRNNTRLNLPSGLRSAWFRSSTGSSRDTSFMRGGRDGRSRGRSSRTQSSPQERGTTTTTPAESNRGGILSSIRSALPFGRQRNQQSATSPATTTNVTPAQLESGTRQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z250</accession>
    <name>A0A7D5Z250_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DAM1</name>
        <name evidence="16" type="ORF">G6M90_00g042160</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547555.2">
        <property type="nucleotide sequence ID" value="XM_014692069.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z250"/>
    <dbReference type="GeneID" id="26240118"/>
    <dbReference type="KEGG" id="mbrn:26240118"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI67227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="165" mass="18565" checksum="A7E99D2683604F09" modified="2021-02-10" version="1">MGMSDGIDEANGCTAMSRKRSNSRARNSRPTTPLRPSSRSSFRDSARNVRGGGAEFPLNAFEPAFAELSDAMADLEANMMHFQLMHESLARFSESFASFLYGLNMNAFCVDFPEGPIAESFARDRHEETSAEGTTRLETDVEATFMYVCPNHFSYNIFLFYVYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2W0</accession>
    <name>A0A7D5Z2W0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-containing monooxygenase EthA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ethA_2</name>
        <name evidence="7" type="ORF">G6M90_00g084650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543681.1">
        <property type="nucleotide sequence ID" value="XM_014688195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2W0"/>
    <dbReference type="GeneID" id="26243858"/>
    <dbReference type="KEGG" id="mbrn:26243858"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000228">
        <property type="entry name" value="FAD-containing monooxygenase EthA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="489" mass="53809" checksum="2DAEEAAC605EAFA9" modified="2021-02-10" version="1">MASAPDFDVVIVGAGISGINTAYRIQSNFPRYRYCILEAREAIGGTWDLFKYPGIRSDSDLFTFGFQWYPWNRNNPIATGESILEYLAEASSKHGIDKNIRFKHKLQHASWSTEYQEWTLSVTRGTKATSISSRFVVFGTGYYDYSTPLQAHIPGLDTFAGQVVHPQFWPSTLDYTDKKVVVIGSGATAVTLVPKLAEKAKLATMLQRSPTYIVALPNRSARSLVDYVLPRAVALRLKRLRWIVTSRLLFLFCRAFPQSARWLFRRGTLRLLPPTTSFDPHFNPSYDPWTQRLCVCPDGDFYKALHTGRADVVTGTIRTVTPAGIQLEAGGFLDADVIVTATGLRIQLGGGATVDVDGRPVAPADKFMWRGAMLQDVPNAFFVMGYTNASWTLGADATATLAVRLLRTLGRKGGTSVVPRVRNPEAIELAPLMNLNSTYVKAAAGAMPKAATGGAFAPRGNYLADEFRAKYGSLDGLEWVRRGEGNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3J3</accession>
    <name>A0A7D5Z3J3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g047000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544823.1">
        <property type="nucleotide sequence ID" value="XM_014689337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3J3"/>
    <dbReference type="GeneID" id="26242164"/>
    <dbReference type="KEGG" id="mbrn:26242164"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="273" mass="28546" checksum="0CA5857CB41525B7" modified="2021-02-10" version="1">MPAIQINNQDLYYSWSPAGEGPILLLIHGLGSSNSFYASIIPGLVQKGFSCLAFDTPGSASSPYRGGDSDGEAICGAAVALIAALELDVKRIVVVGHSMGAIIASELALRLDILGVILIGPVNPSAALADVFDARIKLVENEGMEGVANVVPFAATGPKATTTQKAFIRALLLAQTGEGYKSLCRTIANAKRPRYEDIKCPLLIIAGSHDKTAPLTGSQDILNSWGVEAGLKKRIEILADVGHWHCIEAAPEVEDLVGAFAEAVRSTGQASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3N8</accession>
    <name>A0A7D5Z3N8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aclK</name>
        <name evidence="6" type="ORF">G6M90_00g019490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548592.1">
        <property type="nucleotide sequence ID" value="XM_014693106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3N8"/>
    <dbReference type="GeneID" id="26238036"/>
    <dbReference type="KEGG" id="mbrn:26238036"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="68"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="350" mass="38853" checksum="F822E4C4E9C98306" modified="2021-02-10" version="1">MPSPTDVEPAASVASAALDKAGVSARQPSRGSYPSISSILTTSSERLTKAAQDVHPISDSPGAETVLYLAYGSNMSAKTFLGVRGIRPLSQVNVAVPSLRLTFDLAGVPYMEPCFANVGFRNVPDQKKNTQAELIHQDMEWDGGLIGVVYEVTQEDYRTILRTEGAGSSYKEIVVPCYPIAPKEIFPKGPTPFLARTLYAAYTSNANDDRSWWQHLLDGRQRPDPDYAQPSLRYLSLLRDGGREHDLPTSYQQYLASLHPYFATTWAQKVGQYLFIALWAPLLIFYLITSRFLADETGKLPPWLAGGVTSIFNMMWMSYDAVFKSIFGDGERTEEDESDERKSLLGNRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3Z6</accession>
    <name>A0A7D5Z3Z6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g009150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549595.1">
        <property type="nucleotide sequence ID" value="XM_014694109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3Z6"/>
    <dbReference type="GeneID" id="26239039"/>
    <dbReference type="KEGG" id="mbrn:26239039"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="372"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="50943" checksum="7306F960612A4EC0" modified="2021-02-10" version="1">MASESASTFLWGGRFSSGLDDLMMQFNESLSFDKVLCHADIQGSITFARALQRLSIITADELDQITTGLKKVGEEWDNGTLVINPKSDEDIHTINERRLGEIISTQVAGKLHTGRSRNEQIGVDMRLWARTQLDDISASLKEALKVFTAKAKVSLPVLMPGYTHLQRAQPVRFSHWLLSHATFILGDLQRLGGVQERVAVCPLGVGALAGNPFGIDREFMAKDLGFPSIHPNSLAAVADRDFVVDILQWASLLMVHLSRLSEDLILFSTAEFGFVQVADAYSTGSSLMPQKKNPDSLELIRGKAGRVMGQSSGFLSSLKSLPTSYNKDLQESVEPLIDCIKTVSDCVKITAGVIATLEIRPEKMKAALTADMLATDVADYLVVKGVPFRETHHIAGSVVRKAEEQNVSISELSLEHLREITPLFEADIKDVFDFERSVEKRTSTGGTSKASVLQQIKSIEAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z403</accession>
    <name>A0A7D5Z403_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal peptide synthetase aclP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aclP_1</name>
        <name evidence="7" type="ORF">G6M90_00g080900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539440.1">
        <property type="nucleotide sequence ID" value="XM_014683954.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247759"/>
    <dbReference type="KEGG" id="mbrn:26247759"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1701" mass="188187" checksum="7E7A8E1EACAC657D" modified="2021-02-10" version="1">MDNIILSELSKGLKISKHEITPNSTFHRAGGDSITALRVSAACKRQGVSINVSSILNSQTISELLKGATWLPGHEETFTPEGTTENRHIIGDRDASASPSLDAATPDNLSSATTSTNGTNGINGINGIDGAHGNPGIIKTHDSQGMQMHQRSSRRTDAGVCKMMSLQSSLVLDTRARPGNNVISYFQEYLYSPALVATLKRAWQQVIRSEPIFRTVFDDEMFWDDGMALFSWSESIHHDEGQFEQELQSTSTPGMLDPATEFKVVTLVGKKSVLVWHVHHALVDGYSAHLLLQKVDTVMNGGQISQGYSFADLARGWQMYQAVFQQQATGFWREYLTGMTAVNNDLLLPPPQDQHHGDTPSSGVATFSVPLQGSLRFAQANDLPLCSIYYAAWALTLSIYTGSDSVMFGVLFANRSLPVPAIRDTVGPMMNTLPLLLCLDRRKTLRDLLHYTAERLSKLREYEWSVPDERCPMTSVLAMQYDYEANTDPKFQTESCYTRLQSSIPVNLFLGPKDRIQINYDKKLYDHSDIDKLGQMYTHAIGALIGSETILLNEYFRRPLPPGMWKEIMLNGNCSSTQSRCQGEETLTSLFDDRLESIPSAPAVIRGDSSITYAQLDEAATKVASSLCKTVSPGDVVCVHADRSINWIIAIYAVLRARAVYCPLDPAIPAELRDTYFQTSGSGLFLSTWDVCKDKKPQSTRLCYSVEELLHRAANPSDVSTLSQRPTASKKDTAYLCFTSGSSGLPKGVACTHEGIVAFQKDYDARLRMRPHLKVAQIMSPAFDGSIHEIFSSLSYGGTILLSETADVLSNLQKADVAMITPSVAKLLNPRDYENLEAIYLVGEHLPQAVCDAWSAVMPAFNLYGPTESSCGSTCKRLVCGEKVTIGCPVQSTRIYILDQHQCPLPPGVIGELYTAGVQVSRGYIKRPKETARNFLKDTICPETNQTMYRTQDRGYWNQSGEICLLGRSDRQIKLRGFRLDLDDLEIRMVKASNATSVALARKEDILVAMIQPEITDIALFEEAIKKVLPPQALPRLIKAVEKFPLGNAGKLDYKAISTAFSWEEAEAPSPDPSVSPSIAIDHVRTKIASVWRSVLNLDDGQTLNEDSSFLELGGHSLEQIALSSRLSSALNTRVTLADVMKNITFGDQVKRFRSPASHSANGQLVAGSRPTGQLTGVGGQIEAAWRSLLCLDSNYSLNYDSNFVELGGDSILQQKLTSFLSTIGQERIPLLDVIKRPRLGDQVALLSASHIDRQVGESGPNTGSVLGHSTLSPIEQEWLQKCKLDKGSSSFNVNFVCALSQDLDIKRLERAWNKVLARHAILSSIFPNDHNRVHSKTPPRVILTNNISIRQEVNREFKLHEELPIRVFISPTALVLVASHIVLDLTALNVILSDVQIYWNGKSPDTVPRDYGQTSQWSRDISQDNIDFWGHLSDLLPYCAPTRLNYGGKSRVCKILPETFRAMVHLSTKHGITLHQLSLAAVALAIRHGGPDGRSAVLGSPYLNRGVEDFDTVGLFLEPLVIRVDDPWSSKADLIYRSNSQEDPWTLAFCKRVATASQQALSHSMPWNELLKQHAVVSDHPNVPFIEAMVTFHDNRGREPLSIDGTQPLYTWCEGAKFKIMFEFLALNSDTAMLRMEYDTLLYSETEASYIQSRVIAAIDGLTQQLDRAGIEDKMRQATLSQQHPSDDGSKYFGAKLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z498</accession>
    <name>A0A7D5Z498_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g000920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986144.1">
        <property type="nucleotide sequence ID" value="XM_066129495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z498"/>
    <dbReference type="GeneID" id="90967391"/>
    <dbReference type="KEGG" id="mbrn:90967391"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="8354" checksum="CC46DFFC56504DDE" modified="2021-02-10" version="1">MLHGLAHIASHIDIIEWQSFADAVQRAGKSRENSAALEKTVKRWAVEASAREAAFYALKFLFECLLHGPSKDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z499</accession>
    <name>A0A7D5Z499_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g029100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541257.2">
        <property type="nucleotide sequence ID" value="XM_014685771.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z499"/>
    <dbReference type="GeneID" id="26245892"/>
    <dbReference type="KEGG" id="mbrn:26245892"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="12212" checksum="31EAF89AA11D6467" modified="2021-02-10" version="1">MAVSGGLEQCRFAQQPNWLREIQKNDHGAIRSIHFSQVVSPIWARPSRSAILIRMSPTPQTHTRIVAAAKQLFFALGQRRLDFAHNGNGIHVIGVVAGSSMTRRQTPDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4E5</accession>
    <name>A0A7D5Z4E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g057440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986688.1">
        <property type="nucleotide sequence ID" value="XM_066130643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4E5"/>
    <dbReference type="GeneID" id="26242737"/>
    <dbReference type="KEGG" id="mbrn:26242737"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI68887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="11641" checksum="614AB2635B216D04" modified="2021-02-10" version="1">MSSPRASSPANSPAAASGANIGRPSSPTPPGGPRTAIRRRAAADQKEKIANARPTSTRSAGAGGSSSTMLRLYTDESPGLKVDPVIVLVLSLVFIFSVVALHVIAKITRRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4J9</accession>
    <name>A0A7D5Z4J9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endothiapepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EAPA_3</name>
        <name evidence="10" type="ORF">G6M90_00g063460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542537.1">
        <property type="nucleotide sequence ID" value="XM_014687051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4J9"/>
    <dbReference type="GeneID" id="26244486"/>
    <dbReference type="KEGG" id="mbrn:26244486"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF2">
        <property type="entry name" value="ASPERGILLOPEPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028821859" evidence="8">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="93"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI69027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="407" mass="41769" checksum="3C60D3F822981732" modified="2021-02-10" version="1">MQTFGSFLVSLVVASSLATALPTTPSSTPAGNASVTAKHNANFTRSGPAALAKAYRKFGKPVPVDVTNALNRQSSKRTTGSDPNSPQQYDIEYLAPVQIGTPAQTLNLDFDTGSSDLWVFSSLTPSSQVNGQTLYNPSKSSTAQSLSGSTWSITYGDGSSSSGVVYTDAVTVGGLTVNAQAVEAAKQVSAQFSQDAASSGLLGLAFSSINTVKPTKQKTFFDSAKPALDSALFTADLKHGADGKYNFGYIDSTAYTGSIAYTPVDSSQGFWGFTSKGYAVGGGSLNTASTSGIADTGTTLLLLPSTIVSAYYAKVSGAKYNSSQGGYTFACSQSLPSFSFGVSGATVTVPGAYLNYAPTDSTGRTCFGGLQSSSGIGINIFGDIALKSAFVVFDGGNNRLGWAAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z536</accession>
    <name>A0A7D5Z536_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylglycine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dmg</name>
        <name evidence="6" type="ORF">G6M90_00g065850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540188.1">
        <property type="nucleotide sequence ID" value="XM_014684702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z536"/>
    <dbReference type="GeneID" id="26246997"/>
    <dbReference type="KEGG" id="mbrn:26246997"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="380"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="437"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="746"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="832" mass="91145" checksum="C7AB9D6DB48B59A2" modified="2021-02-10" version="1">MAVTASQPRVVIIGAGIVGVNLADELVSRGWSDITVVDQGPLDMPGGSTSHAPGLVFQTNASKTMTLLAKYTVDKFLSLQEDGQSCFNQVGGLELATTPERLEELKRKHGYASSWGVEARLITPEECLERYPLLNKDMVLGGLYIPSDGLALAARAVQLLIAKTREQGVKYIGSSLVTGVEQADGRVSAVVTKDQTIPADVVVSCAGFWGVEVGAMVGLPVPLLPMAHQYVKTTAVPSQRGRYSSPNGAGLPILRYQDQDLYYREHGDQYGIGYYGHRPMPVVASTLGPTPEHVDEHKMPSRLDFTQEDFDPAWKLSRELLPVLQQTEIEDGFNGIFSFTPDGGPLVGQSPTVDGFYVAEAVWVTHSAGVARALAEVLTTGKSQVDLAECDITRFEEVQLTPQFVSETSQQNFVEVYDILHPLQPRDSPRNMRVSPFYHRHKELGAFFLEAGAWERPYWFEANEALLKELPAEWQPVERDAWSGRYYSPIAAAEAWKTRTSVAMYDMTPLRRLEVSGPGAVGLLDWATTGNVSRKPGAVTYTLLLDEQGGIRSDITVARIRDDLFQVGVNGPVDLAYLSREARIQTKNAPEKAVHVRDITGATCCIGLWGPKAREVISQVTPDDFSDKGLRYFRVKKASIAGVPVTAMRLSYVGELGWELYASAENGLRLWDALWKAGQSCGIIAAGRSAFNSLRLEKGFRSWGADMTTEHNPYEAGVDFAVKMDKKGAFIGQSSLRGVSKDTITRKLRCITVDDGKSMVLGKEPVFFGGKSEGYVTSAAFAFTIGKPIAYAYLPTNIQEGDAVELEYFGTRIPATVTAEPLYDPEMKRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z576</accession>
    <name>A0A7D5Z576_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase ustM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ustM</name>
        <name evidence="1" type="ORF">G6M90_00g046750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544799.1">
        <property type="nucleotide sequence ID" value="XM_014689313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z576"/>
    <dbReference type="GeneID" id="26242140"/>
    <dbReference type="KEGG" id="mbrn:26242140"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="291" mass="31059" checksum="70B538AFBCE5C621" modified="2021-02-10" version="1">MPSFTPLAAEAAGKIASYAILDDPNHLAVETGQAEHRIGLVNSWQIRQGSRVLEIGCGQGTCTAVLAEAVGPEGHVDAVDPGPPDYGAPVTLAQAQAHLSAGPVGDRITWYHAEPVQFLAENPGTRWDFVVLAHCIWYFDGPDTLGEMLAALRGRAAGLLVAEYALTARERAAVPHVMAAVARAALEAHNKTSEANIRCLLGPLSIKDAAARGGWALDKEEVHVPGVALLDGSWETGTVKSRWFLEEIDKYITDVTLKTTLLSAREAVVGAVGLLNGEKVRTMDVWVSRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5D8</accession>
    <name>A0A7D5Z5D8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING-box protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rbx1</name>
        <name evidence="13" type="ORF">G6M90_00g057990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986803.1">
        <property type="nucleotide sequence ID" value="XM_066130655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5D8"/>
    <dbReference type="GeneID" id="90967816"/>
    <dbReference type="KEGG" id="mbrn:90967816"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI69446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="116" mass="13108" checksum="DDDD76821B55A4AF" modified="2021-02-10" version="1">MADVEMSDAPSASKRADAANGKGSEAKKKFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGICNHAFHFHCISRWLKARSVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5N2</accession>
    <name>A0A7D5Z5N2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g036030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546996.1">
        <property type="nucleotide sequence ID" value="XM_014691510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5N2"/>
    <dbReference type="GeneID" id="26239559"/>
    <dbReference type="KEGG" id="mbrn:26239559"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="69"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI67209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="755" mass="84373" checksum="869EA607E3E7960C" modified="2021-02-10" version="1">MGDRENGWTTVGHRILGHGHQLGTGREWMMQRELTDLEAIAAWDSEAQWPSINKPLFDGPEAKKFDNKLVKLHDLDQGAFGRVDKVMHGSVCLARKRIPRRRGFSIDDLRKEGLMMRKLDHRHVVKLVATYAPRSHELCLLIWPAAVCNLGRLLDDVESLRLKEGDREDIVERLTALDLRDLSAIDPMAKDQYLTPIPESCPFDFLRTIIGCVARAMAHCHANDVRHLDIKPSNILLHPGRVYLADFGISRDVTGQEQTTTDGMPGTERWRAPELYGEHGSSMQLSDMYSLGLVYLNIATVLYDARLADFDEALSYSGRLSREEQLRLREDKVKMHLDRLTAHALVRPPFMFTYEGQETVRPRPLTHLISRMVATNPRHRLTAAKVDEKLSMLGGINQIYHADCCKRPISWVEDKWDRKFAGLIALQKENEAHRKRIMELEGKDQTYETRLEKQRQKHEQDISRLQTLLKNAEEKCQRLESEMTDRRKVSHSSRGSHGHDVPRPVLSGGRRQPAGSATTQGVGLGLNRSSLTTPKTTVAKPPPQHIPQRSQSISSTPSERPTQKMRTLQSSPAVTQSSDAKSLAGQRSPSISGNLAGYALRSRGSGSKLPLPVTPSRTNTPVFNRDQSMTDSSMASSVFSRKSLETLPTPPAHDSPIIQRADVSSENAQPQWGQLGGRRGPRITDETALRPSTPDSPLPPISPSAMSSPQTLRSDILTDGGDANATSRPPPPSLQPMKSWADVAKSEKKRQATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6G0</accession>
    <name>A0A7D5Z6G0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">G6M90_00g071620</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545897.1">
        <property type="nucleotide sequence ID" value="XM_014690411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6G0"/>
    <dbReference type="GeneID" id="26241930"/>
    <dbReference type="KEGG" id="mbrn:26241930"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="112"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="299"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI70367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="769" mass="86809" checksum="7968286779CA4DE3" modified="2021-02-10" version="1">MSDFSESKANKRASADIDETSRKKSKKGDREGTYNPYLAHMDQESNGYGGDEAPPGSALEGMKRRQTTAAQASKAEDSAINPFTGKPHSQQYFRILETRRDLPVHKQRQEFLEKYQSTQILVFVGETGSGKTTQIPQYVIYDELPKVTGKLIACTQPRRVAATSVAQRVADEMDVTLGDEVGYSVRFDDCSSPKTMLKYMTDGMLLREAMHDHDMSRYSCIILDEAHERTLATDILMALLKQIASRRPDLKIIVMSATLDAQKFQKYFNDAPLLAVPGRTHPVEIFYTPEPEKDYVEAAIRTVLQIHASEGDGDILLFLTGEDEIEDACRKISLEADELQREVDAGPLVVYPLYGTLPPHQQQKIFEKAPPPLRKGGRPGRKVIVSTNIAETSLTIDGIVYVVDPGFSKQKIYNPRIRVESLLVSPISKASAQQRAGRAGRTKPGKCFRLYTEKAFKKELIQQTYPEILRSNLANTVLELKKLGVEDLVHFDLMDPPAPETMMRALEELNYLACLDDDGELTTLGSLASEFPLDPSLAVMLISSPEFYCSNEILSITSLLSVPQVFIRPANNRKRADEMKSHFSHPDGDHLTLLNAYHAFRGQATSDPDKLKQWCHEHFLSFRHLSSADSVRAQLKRIMETHGLELVSTPFEDKNYYTNIRRALLAGFFMQVAMKESSGKVYRTVKDDQAVLIHPSTVLRTEFDWVLYNEFVLTSKQYIRTCTGIRPEWLLEIAPVYYDLNTFEQGDVKRSLARAAEKKRRKEAMKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6H7</accession>
    <name>A0A7D5Z6H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g035900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546985.1">
        <property type="nucleotide sequence ID" value="XM_014691499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6H7"/>
    <dbReference type="GeneID" id="26239548"/>
    <dbReference type="KEGG" id="mbrn:26239548"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="6">
        <location>
            <begin position="168"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="407" mass="44584" checksum="E7708A3EBAC69EDD" modified="2021-02-10" version="1">MLLLRRVTPRELRLCQHTYTRKAPFSASPCPCIRQRPNRPSPSRPIQTPREKDSNLDRDRNARPNDDPLPAPSQPRASASSPGRPLAIQQARESATPDTSTSGPYKQVLLTSKSIRHNPLATSPIHITTRTSKSYTQQLSAADKFFSSSPCRFLYSAEALRHHSMNNVTPEIVVLGSSNVGKSTFLNALVGQPKAARVSQKPGRTTLMNAYGVGPLPKIPRGLVPKGMPPPRHSLVVVDTPGYGFKSQASWGDAVIKYLQARRTLRGAVVLLSSEKKLLPEDKWMLRTLAEANTRTVVVLTRADKARNGWVETCSLLADVVQQEVDRLDQEFGGKWKDGQDAASRIYITAAGMESPGRLRNGGGIGGVRTAILEMAGFTLQETVAKKADTVAYTGPVVSFDDIEWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6Q6</accession>
    <name>A0A7D5Z6Q6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-rhamnose-1-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DHG2</name>
        <name evidence="5" type="ORF">G6M90_00g070110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540664.1">
        <property type="nucleotide sequence ID" value="XM_014685178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6Q6"/>
    <dbReference type="GeneID" id="26246537"/>
    <dbReference type="KEGG" id="mbrn:26246537"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="277" mass="28421" checksum="352871151855CC76" modified="2021-02-10" version="1">MPLTGLLAGKTAIITGGTTGIGRAICLEFLRQGANVVVNHLGLDQDKQHLDSLVAEAEALSLSAQASPSSAVGRLAHEAGDVRDPETAAGLVAAAVAHSGAARRLDICVSNAGVCTFADFLTLAPDLLETTVRTNLDGAFYVTQAAARQMALRQEPPGGSIIGVSSVSALVGGGRQAHYTPTKAGVLSLMQSAAVALGRHGIRCNALLPGTIRTRLNEQDLADDAKRAYMEGRIPLGRTGVPSDMAGPAVFLACDELSGYVSGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6R8</accession>
    <name>A0A7D5Z6R8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nop56</name>
        <name evidence="8" type="ORF">G6M90_00g044880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547817.1">
        <property type="nucleotide sequence ID" value="XM_014692331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6R8"/>
    <dbReference type="GeneID" id="26240380"/>
    <dbReference type="KEGG" id="mbrn:26240380"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="301"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="55746" checksum="EBE386AA2F7BB3F1" modified="2021-02-10" version="1">MSHIDYALYESPVGYALFQVVHQSDAVGLKLKETQAAVNDLAKFGKMVKLTNFSPFRGHVEALENINLVSEGIVSEYLKSVLELNLPKAGKKTKVVLGVSEKNLAGAIKSEFPGLECETADTSDIVGDVIRGLRLHADKLLKDLKPGDIEKAGLGMGHAYSRAKVKFSVTKNDNHIIQASATIDFQDKGVNQFFMRVREWYGWHFPELVKIIPDNLTYAKLVLAIGDKKTLNDEKLHDLAAILGEDGDKAQAIIDAAKVSMGLDIAAADLEIIAGFAEAVVKQAENRKTTSAYLEKKMGHVAPNLQALIGTPVAARLISHAGSLTNLSKYPASTLQILGAEKALFRALKTKSNTPKYGLIYHSSFIGKAGVRNKGRISRYLANKCSMASRIDNFSEEPSTRFGEALRQQVEDRLEFYASGKKPAKNADVMKSVMSVLGDGAGKDSDDEMADAPASAKKEKKDKKDKKDKKEKKEKKRKRDEEEAPPADDDAEKKKKKKKRKSKAADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z758</accession>
    <name>A0A7D5Z758_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g104750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541466.1">
        <property type="nucleotide sequence ID" value="XM_014685980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z758"/>
    <dbReference type="GeneID" id="26245716"/>
    <dbReference type="KEGG" id="mbrn:26245716"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="141"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="460" mass="51664" checksum="5DDE4F1D88FFF86A" modified="2021-02-10" version="1">MPLWSCDFGHCHRPAVRTIGDCVLCNRHLCSSHLRPGIHDCPCWEDADAYDPASRDAEERELTDLIKKVNTRALAARASHLRQGVPCSTPLLKYDRETRSSVMGGMNYHIEVRFEDGVVWIARIRRFNASSPPPALRDYIIQSEVATLMFLKHTNVPAPEVYDYALEGAPGNTVGVGYILMQKLPGKSLRWSIATPEQRENVMSQMADIFIELHKHPFPLLGSLDSPGTSHIGAYARESLTNFAQSTMCTTGPFSCPRDYHVASIRLILDLITKDEIYSQRAVDAYLIHRFLLDLVPRVLPSTQSNTFYLKHADDKGDHILVDEKFNITGIIDWEWAHTATAADAFNSPIGFLPVADFYNGKNSLGDDETIFAQLLEAKGRQDLAQIVRNGRLQHRFAFCCGYDLADWDGFLGLFRGLREAVAVDEGLEWNEWKAVALDRYKDDSGLQLVLSKLQDAAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z766</accession>
    <name>A0A7D5Z766_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysophospholipid acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ale1</name>
        <name evidence="8" type="ORF">G6M90_00g057900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544370.2">
        <property type="nucleotide sequence ID" value="XM_014688884.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z766"/>
    <dbReference type="GeneID" id="26242782"/>
    <dbReference type="KEGG" id="mbrn:26242782"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="538" mass="60913" checksum="1FC4C5D6EF5D61A8" modified="2021-02-10" version="1">MLRFIHHPFEVVSKKLGASPDELKLIFSFILSYPLAGLLKRVPDAKPYRKNLFIIGTSIFYLIGLFDLWDGLSTLALSAGGVYLIAKYMKNSYYMPWVGFMFVMGHMSISHIRRQAANSPSSVDITGAQMVLVMKLSAFCWNVADGQLPDEVLSDFQKDRALCELPSILDYAGYTLFFPSLFAGPAFDYVDYRRWVDTSMFDMPPNVDPSKKPPSRKKRKIPRSGTPATFKAFLGLFWISLFVVLSASYGHDQLLVDTYMHHALWRRIWIMYMVNLVTRLKYYGVWTLTEGSCILAGLGYNGVDPITGKVFWNRLQNVDPWVVETAQNPRGYLAGWNMNTNSWLRNYVYLRVTPRGKKPGFRASMMTFVTSAFWHGFYPGYYLTFVLASLIQTAAKNFRRLVRPFFLDAITGGPSPRKKYYDAASLIVTQLTFSFATTPFLVLTFADSIRAWSRVYFYGAAWTVIGLLFFASPGKAVLKAELEKRQGKASAKLVRSASTDSLTGKDPILGISKDPERDVTEAMAEIRAEVEARQKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7V0</accession>
    <name>A0A7D5Z7V0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase helC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">helC</name>
        <name evidence="3" type="ORF">G6M90_00g052750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7V0"/>
    <dbReference type="GeneID" id="26246763"/>
    <dbReference type="KEGG" id="mbrn:26246763"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="28264" checksum="C767A7FF05E00F25" modified="2021-02-10" version="1">MSSSPQVAVVTGAAQGVGLAVAKLLAARNYQVVLSDIDVAAGEQAVVDINASLGKQVAHFIPCDLAKTDDIDRLFQLTTDKFSGFSVLVNNAGFLRAPFLAIDAQQISDTIAINLTATVYATHQAIRFWESHADTIQDANVVNITSSSSFKTYASIAAYGAAKAGAAQFTFACRSFGPRIRVNAVAPTAIATAFDKNTMMRVPTDKSGPGYTPEEEMRAMGLARLQPEQVAEAALQCIDDRDRFGKVVYLDATEGQRIHAGFLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7Z7</accession>
    <name>A0A7D5Z7Z7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542653.1">
        <property type="nucleotide sequence ID" value="XM_014687167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7Z7"/>
    <dbReference type="GeneID" id="26244602"/>
    <dbReference type="KEGG" id="mbrn:26244602"/>
    <dbReference type="OrthoDB" id="5149762at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028961453" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20703" checksum="F2119D18169AC46C" modified="2021-02-10" version="1">MLALTILLSAAAGVNAILGGEVQAVQISNTTHICADNCVYDGIYLAQKGYFCPVKEVVRQEEGGKLREWYSYDCRGAKPAPGVVHAPLKGKEAPRNCTLFPGDLTKVSPSCIADKEVGGGGGTKILQLSELTEMLKSATANTADNKKPASPKSKKECAQIARNKFTECREKIDDFNECNNQGAKTFQNCQSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8L5</accession>
    <name>A0A7D5Z8L5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g081160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543357.1">
        <property type="nucleotide sequence ID" value="XM_014687871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8L5"/>
    <dbReference type="GeneID" id="26243534"/>
    <dbReference type="KEGG" id="mbrn:26243534"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="548" mass="59182" checksum="13F5913C50972F8E" modified="2021-02-10" version="1">MSLQEKGNTPPGEWPPGDATPRQTPAQTPCKVSEESHHGSRHGHTHDDDLDDHTEARVQRPQSLAGEVLFIAVICSSQLLAQAGLALSIVPQHIIARSFGIENQPGEVSWFSAAYSLTVGTFILIAGRLGDVFGHKRFFVGGFAWYGLWSALAGVAVYSGPVFFAFCRAMQGIGPAFLLPNSIAIIGRCYDPGLRQNMIFSLFGATAPSGFLLGAVFASLLSQMAWWPWAYWVMCFACLLLALLGVFAIPATPPPTNPEHEGSSAWQRVDVFGSVTGVAALALFNFAWNQGPVVGWPTPYTYFTMIIGILIFVVFVLVEKRARHPLIPFGVLKIDSLFTLACVSAGWASFGIFIYYIWNFLVVLRGQTPLYTSAQFAPIAISGLLAAVTTGLALSHLRPSTVMLISMTAFLVGGIIFATVPVHQTYWAQTFVSVIVFPWGMDMSFPAATIVLSRAMPRQHQGLAASLVNTFVNYSISIGLGFAGTVDSQVSDGGKNVLRGYRGAFYMGIGLSSLGVVVALIFCFLERRRSNVSEEIAGGSSQMEVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9D4</accession>
    <name>A0A7D5Z9D4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRYP_10</name>
        <name evidence="6" type="ORF">G6M90_00g080780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539325.1">
        <property type="nucleotide sequence ID" value="XM_014683839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9D4"/>
    <dbReference type="GeneID" id="26247868"/>
    <dbReference type="KEGG" id="mbrn:26247868"/>
    <dbReference type="OrthoDB" id="4915747at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028881503" evidence="4">
        <location>
            <begin position="23"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38090" checksum="D605873F2B22A692" modified="2021-02-10" version="1">MVRKVVTALAVALSAISATATAIDKRIVGGEEATLKDLSQYPYLVSVHPMGGSYHFCGGILLDSTTVLTAAHCLYRPVKCREKPEDCQGDVFLVRAGSLDRETGGTVSEVASFKIHPSYDGHVNNAYPHDIAILKLSTSIQESNIIRYGYAKLAASGSDPVPDSIALAPGWGLLEFSGPMPDKLRQVYVPIRARDSCKGATEAMVCAGGDGKDTCTGDSGGPLIDRESGQVVGIVSSGVGCGGTGLYTRVASYISFINENLGDKGTPTREQQLQDHCGRSGNDKDACMFAARRCTGQVKPDATMLEFLQCVDVMQVCGEQDVADKTNQCIANAKVCREQEKLPLGDLDKLSQCAKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9H3</accession>
    <name>A0A7D5Z9H3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g091050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541759.1">
        <property type="nucleotide sequence ID" value="XM_014686273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9H3"/>
    <dbReference type="GeneID" id="26245622"/>
    <dbReference type="KEGG" id="mbrn:26245622"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="171"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="660" mass="74941" checksum="25EDCB256F96085A" modified="2021-02-10" version="1">MFRRSTLILSRAPCRVPRVGLARSDVVAAASRRGIQTPGGFSPLRPPSPEELGAPRAAKQYNKGRRWTRWLVTGLAAGGAVYVADRQIYASGFARTLRTFATTLLVALDYKINFRPEPLTAGSVPELHARNAERLFDLLRANGGLYLKIGQAIAMQSAVLPPEFQKMFGRMFDDAPQDDWRDVEAVIRRDFGRSVEDVFGVSFTGKEGMGVMERRARASASVAQVHWARLPDGREVAVKIQKREIAKQIAWDLWAFRAVTWIYSKWFDLPLYTLVPFITERLELETDFLNEAKNSETMRNLVNSESSLRGRVYVPVVHADLTTKRVLTTEWIEGVRLWDKKALTSRWLGGRGKGSPGAQTALPPVDMAAARRELRARPYNEKIKPARQEWKGARGRGGLGLSTTEVMTTMVDLFSAQIFKWGVVHCDPHPGNIFIRRLPSGRAELVLIDHGLYVYMSPTFRRQYSAFWKALMTFDNGTIARVTSEWGIRGADFFASATLMRPYEGGDNSLRDSIRKDLEGKTPAERHYAMQQLMKQSLRDMLADEDKWPKELVFIGRNMRIVQGNNQYLGSPVNRVKMMGEWASRSLFQDKNLPVAQRMTNAWRHLLFKAVMFGTDVAFYFFKLRQWLGLGGGMEDEMERRMRGVAQDYGIELQHDVFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC97</accession>
    <name>A0A7D5ZC97_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g092560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541900.2">
        <property type="nucleotide sequence ID" value="XM_014686414.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZC97"/>
    <dbReference type="GeneID" id="26245368"/>
    <dbReference type="KEGG" id="mbrn:26245368"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="265" mass="29113" checksum="0A8A69682EB49DC3" modified="2021-02-10" version="1">MTFDDAAMAAEQSGILIEQINTAEDMVEAINPVCETFGKQTHDGLWTAMNPSWDTPQGKAQATSRMVHRWRAATKDHQGRPNTIFLKATVPRDGAAPGGARKIVGTAIWLQLSSVAGHGDLPAEDLSKALDLDKIYPGNEAEQRYLCQAIHSLHRQRIDLVKKKADSLPPSAMVLDLCVVDPAYQGRGIAKQLVQWGLDEAKTRGGLECITEASVMGRRVYEKMGFRQEGPEIVYVVDEQFAHRDRPSNVFMRTGNGELGSLSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCN2</accession>
    <name>A0A7D5ZCN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g099650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546384.1">
        <property type="nucleotide sequence ID" value="XM_014690898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCN2"/>
    <dbReference type="GeneID" id="26240807"/>
    <dbReference type="KEGG" id="mbrn:26240807"/>
    <dbReference type="OrthoDB" id="5428038at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="677" mass="76663" checksum="16234C7C36050227" modified="2021-02-10" version="1">MPTRSPAKGHSPAIVSNIGIWVTDAMLLHAVERYQRGVVASCRRIHSHAGPLESRRRATRRHMTGLMPTSHPYPPIWQFGVGPSSMEWEAPTTQQHRRQKREQISVSNMFNNLIGWLENVGSTDRPFISPPSQRFEAGAVSAEALAINPAVEAVDVPGPMLQEPTSLQHLPEEIIKLRSSIFGFDIVDNKTLFKLTKTCRQSLRRRVERGDLSVEALLAALEPLDSASKSRIPTAEMVNKLRAMIRRSILYAMVDAEKQTPRSISPDLWLAFVGRVCASNGDNHDIQLFWRLMAAVPSSVGERILPEQIRNLAIAFVTAQANRHNLFGHWSARAARFGQSLESLNASQRQELDDGMIKFLLQQDWISERARRMRFSWLVIKSYDNQTTTNEFIQTVHACSGKELQLHVVQLWQVLAARLHAIGALDNEAHKQVLQDGHNTSMSQRWTSLVAALMTSSNRNSALQELCTILTEMGQFDAVVHALTGKPVHLLRRDVMEALASACDNHHQALQLYDSIDLRRQPVRRRPLWAWSVWTKYVEQMIKDPTVQPIRIWQVLNLTSRQNEPTVETKAKSQLLDQMGQWFVEAQHLTDRQVLRNVEKCISLQRPLTDGVSSQMLANLADIITRDLDKSQRGRTSRMQWLLSMVAQNQGQEQASRTASALNGWRAQIEPRGSEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDY6</accession>
    <name>A0A7D5ZDY6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g113030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987811.1">
        <property type="nucleotide sequence ID" value="XM_066131878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDY6"/>
    <dbReference type="GeneID" id="90968285"/>
    <dbReference type="KEGG" id="mbrn:90968285"/>
    <dbReference type="OrthoDB" id="5104857at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="119" mass="12900" checksum="21BA93087E8BB8A5" modified="2021-02-10" version="1">MARLTALASEPTASLEIINGKEMYHNDVFPILACLLWPATAIHSMCLTSPIISLEAGQSVLSAVINAPQSTRCYVTMNFGDSSFLPLRFNFSTTQCDGQMIATFTTPAEVPNGEADILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPM8</accession>
    <name>A0A7D5UPM8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BGL1B_0</name>
        <name evidence="8" type="ORF">G6M90_00g014880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549036.1">
        <property type="nucleotide sequence ID" value="XM_014693550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPM8"/>
    <dbReference type="GeneID" id="26238480"/>
    <dbReference type="KEGG" id="mbrn:26238480"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="478" mass="53952" checksum="E42658609AE3F624" modified="2021-02-10" version="1">MSLPSDFLWGFATAAYQIEGAVEQDGRAPTIWDTFCNRPGKIADGSSGTTACDSYNRTADDIALLKSLGATAYRFSLSWTRIIPLGGRNDPVNQPGLDHYVRFVHDLLAAGITPFVTLLHWDVPDELDKRYGGLLDKTEFGLDFEHYARVCFRAMPEVKHWATFNEPWCSAVLGYNVGQFAPGRTSDRAKSSEGDGTTEPWIAAHTLLVAHGRAVKSYRDEFKAAAQGEIGIVLNGDAVFPWDPADPRDVEACERKIEFAISWFADPIYKGDYPESMKRQLGSRLPAFTPEEAALVHGSNDFYGMNHYTANYVKNRPGTPDPEDVAGHLDVLFYNKRGFCIGEETQSPWLRPCAAGFRDLMVWISKRYNYPKIYITENGTSVKGENDLPMEKILDDDFRVRYYNDYVRAMATTVSLDGVDVRGYFAWSLMDNFEWAEGYETRFGVCYVDYDNGQKRFPKKSARFLGPLFDKLIRKEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPP3</accession>
    <name>A0A7D5UPP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Lid2 complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">snt2</name>
        <name evidence="12" type="ORF">G6M90_00g012310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985639.1">
        <property type="nucleotide sequence ID" value="XM_066129727.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238735"/>
    <dbReference type="KEGG" id="mbrn:26238735"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036205">
        <property type="term" value="P:histone catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15497">
        <property type="entry name" value="PHD1_Snt2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000377">
        <property type="entry name" value="DNA-binding E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000018">
        <property type="entry name" value="Lid2 complex component snt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000486">
        <property type="entry name" value="PHD finger and BAH domain (Snt2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000899">
        <property type="entry name" value="PHD finger and BAH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029617">
        <property type="entry name" value="Snt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47672:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="9">
        <location>
            <begin position="200"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="356"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="ELM2" evidence="10">
        <location>
            <begin position="496"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="912"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI63734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1482" mass="166229" checksum="E00649FAB9817191" modified="2021-02-10" version="1">MAQQNDSKVTNADAQSAPDPVNASSNPDPSSKDLGADMAAGYGTRSRNRGGNARINYAEDKDIDMDVYDYYDKKDQDVPKKSSRKSDVAANGDGAARAVGSRRAAAEEARAVGASNQNGSKSSTPSGVGVGVGGGASQGAPTSGAAQGSRKRKATAVSTRKAGQMGQLEGTPMPETNMLTFENCNHRPDANGCMVADDGTVLEPNDHVYLVCEPPGEPYYLGRIMEFLHVHAKGESKRVDSVRINWFYRPKDIGRKNTDTRLLFATMHSDISPLTALRGKCQIRHRVDIDNLETYRRTPDCFWYEKLYDRYIQKNYDLIPTSTIVNVPDKVKKVLDERWKFVLVEQGRGKELTSAVKLCKRCSGYCASNDSVDCAVCQNTYHMNCVKPPLLKKPSRGFAWSCAACSRAQERKLEARNTPNGTDANGDADDDDALDDDDDDMPGIITDRTTPADNEEHHHATAEQIYQASLWPWRYLGMHCKPEDALDYDDRIHPRASTRIGPRHQANVGVWPGRPVEYVKPLETRKGRGVPKLSKEAQIAQEAEKALRTKRPKWVQDEPPGYQVRGEDLDENDPAATSTRLWMPPPSDTVGDDDIVGYMTKAQGMAKRFNIPERSTNLQDVALETLFRHDYDPAAALKALPDTKRDSFKEPTLTPVENRKFEEGVAKYGSELHLVMKHVKTMTPGAVVRWYYTWKKTERGRQVWGSYSGRKGKKLAKKEETAASKAADDVADADDDSAFDTEKALVQKRSFICLFCESQDCRQWRRAPASQGPLSENGGRATSKDKGNQSVVALCRRCAELWRRYAVRYEPPEDLIKKAGQSGAKIWKKKQEEELLKEIQIAEDMGLMSPYRSSTPATSVNGLEPPRKKLKGAPERDTDAVVSDAGSNTTVSRKKDKTAETTPVPDLPKPRTLPCAICDQMEPLGDQHLSCRECRLTVHRHCYGVMDNRIQGKWICDMCSNDKSPQVSIQYKCVLCPVEYTEQDFIEQPKLTHHKKKMSDKDRERERLEVQQARKAAEFYRKRQEDLNRPVNPREPLKRTADNNWVHVTCAVWTPEVKFGNAKALEPSEGIPSIPRARYDEVCQVCNQQGGACVSCHQCRIPYHVECARQAGHLLAFDITPVKSSRRDQFNIVTVKGEIGTMSAVVWCQDHIPTKTMAHKMYDVVSESGLSALQLYVQHYKQADLGLTGTVRKANLMMAAAKMSGLPLVPGARRTSAISATTAAAAPNGASSHSRNREPMDAATNAQQPGEKVCITCGIDVTPRWWPIEKTQEQQLTNGHHGAIGFEAQKFVEQRKFQCHKCKKNPRTPKSFAAAPKHPHHHRCEALHEYSLQIIEQLLCVQKSIHCCITHHPMVRQHLARQHLARQQLMGHHPEGILPHTRRRIRSALDLGQYLMAIPKYRPQGQRTTIGGANTARRLDTLMEDRHHYHCTTLDRLQHRALQRCGHRLCRGRPRWPQSLFHTSVHMAPRYMEAHCPPHRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPQ7</accession>
    <name>A0A7D5UPQ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548663.1">
        <property type="nucleotide sequence ID" value="XM_014693177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPQ7"/>
    <dbReference type="GeneID" id="26238107"/>
    <dbReference type="KEGG" id="mbrn:26238107"/>
    <dbReference type="OrthoDB" id="10651859at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="407" mass="46911" checksum="7908ACE07B4E2D6E" modified="2021-02-10" version="1">MSNNVDMSFVALQPAQDQQVQGNNGLVEGQNLYSDRGQVQPLPDDDVIFVEQQQLQQQQQRRQQQQHLQQLQQQQMQQMHLQQQQQQLQRMCEQEQQRQQAWLHGSPNSQAFWQPRQPPALPAFLPQQQQQQQQPQHQGWTNYHYQAPQPSCPAPYPAPHPAPLPAMQHPRYPVQPQYPGLPQFPMQPQQPMQPMQAYQGYSQPPQWPQQPLQGLQAPPPPPPPPQPPQPQLQPQPQPQQQPRPQPRPRPRRARQPRQPRKPRQSRRATSQSRTPAPQQPEQPQQPQPQPQQPLPQPLPQPQQQQQPQQQQQQQQQLTPPIGDVEAAMLQAFRQIDALEEEEAQGDDEVVVVDPFDELRAARPGLRTPVNFPLLLPPMAIWHEGVARDKEDKDKDDNDNDNDAPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPT6</accession>
    <name>A0A7D5UPT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TOP1</name>
        <name evidence="11" type="ORF">G6M90_00g012530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549269.1">
        <property type="nucleotide sequence ID" value="XM_014693783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPT6"/>
    <dbReference type="GeneID" id="26238713"/>
    <dbReference type="KEGG" id="mbrn:26238713"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00660">
        <property type="entry name" value="Topoisomer_IB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="422"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI63713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="907" mass="103127" checksum="772BB6A92E99022F" modified="2021-02-10" version="1">MSSDSSDDDRPLARPNGHLSSAKVSRAEDQALDRSQPRKSSGMTGIVVRNGQVDDAMDLDAPNGVNKRKSRSSISKVSYRDESDSDGEPLAKRPRPSARPVDSDSDDEPISKVKAKKKSTSMLADSSDDEKPLGIQLAKKKAAIEKKAAREAQTIRSKETAKSTPKKNIKEESDDEPLAKSSANKRQSNGASAKRKSNGVKKEESDSDAPISKKTKAKGKTTASSKGKSTASTKDSKKAKVKETSEDEEGYAWWNAPKPEDDSIKWQTLEHNGVLFAPEYEPLPKNVKLLYDGKPVTLSKEAEEVATFWVAMMTPASSHHLDNPVFRNNFFTDFSEIVKKNGGATDREGNKVQIKSLDKCDFSKIYDHWLAKTEANKTKNLSKEEKEAAKAKKDALEAPYLHCIWDGRKQKVGNFRVEPPSLFRGRGEHPKTGRVKTRVFPEQITINIGKDAKIPEPPAGHKWKAVQHDQKATWLAMWQENINGAYKYVMLGAASDVKGQSDYKKFEKARELKKYIDKIRKDYTRELKSEVMADRQRATAMYLIDQLALRAGNEKDTENEADTVGCCSLKYEHITLEPPNKVTFDFLGKDSIRYNETAFVEPQVFKNLKLFKKAPKSDGDDLFDRLTTSQLNKHLNSYMTGLTAKVFRTYNASYTMSTLLKELSQDPRSKGSIAEKVKLYNDCNRKVAILCNHKRTVGAGHEQQMQKMGDRIKGLRYQKWRTKKMILDLEPSYKKKKGASWFELDEDLDQEWIQEHQQFLIEEQRTKITKKFEKDNEKRKANKEKPMPEKELKERLQVVKDLETKFRKENKIGKVEAEGRGASVDKYLKAIEKLDERVKVLETQAEDRDGNKEVALGTSKINYIDPRLTVVFAKKFDVPIEKFFSKTLRDKFRWAIKSVEDTEDWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQG3</accession>
    <name>A0A7D5UQG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DPP4</name>
        <name evidence="8" type="ORF">G6M90_00g021300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548418.1">
        <property type="nucleotide sequence ID" value="XM_014692932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQG3"/>
    <dbReference type="GeneID" id="26237862"/>
    <dbReference type="KEGG" id="mbrn:26237862"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="482"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="706" mass="79040" checksum="02CA959E1BE4B854" modified="2021-02-10" version="1">MVRVQKLTAETLIGAPRRSAAVPNHDGKLALYTISTHKFGDKTEKQVRVMDLQTRQSSQISDDDKVHDAVWVPGTNDILFLKSGDKGRTQAIVAKGRDGSWEHIPLAEFNGPIENLKLKKLDDGSVVFMVTGQVDDDGLLYNEEAHQKLSTGRIFDGARVRSWTSLQNQQSYSLWYNKLQQDSSGKWEFAGHLLNLVNNHELDAPGGMLDVGDPLSSFDISHRGAVFIAQDRTVLDPGEFAVSSAYFVPLDSFTLPPTGRPKRIQLPSGVDECIMSNIRFSPDGTMIGFLHVPRGDEYGSRLLLASTNSLDAFDAFGLVTPTWGGGDKEHDPPKEFEFAGDSENIIMTSANCGRTVLSKLKLADGETPHIFFKHGSASACYPLKDDNWNEVLVSSSSFIDSSLWQVVNVSEAAVVKTLSSATSEGKKFRLSPDMVTEFWYEGADDVCVHCFMLRPTDFDENKKYPWVLMPHGGPISSWDDAWSTRWNMAAWAEQGYVIVCPNITGSVGYGLEFARRINGEWGGRPFQDLLNLITYLEKLPYLDQDKAVLAGASYGGYMVSWMLGHEIINKFCCAIWHDGIFNLPSFFLQTDALYEGGNFEGALYPWQRPMAFERFNPARPELLRNWRNAPPTLVIHSEKDYRCPITEGIATYNTLKGNGVPSRLLTFPNEGHWVLDPENSLVWHNTVWDWVKRCVNGEIKRGDTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQZ4</accession>
    <name>A0A7D5UQZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">VPS13</name>
        <name evidence="11" type="ORF">G6M90_00g010160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549501.1">
        <property type="nucleotide sequence ID" value="XM_014694015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238945"/>
    <dbReference type="KEGG" id="mbrn:26238945"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056747">
        <property type="entry name" value="VPS13-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017148">
        <property type="entry name" value="VPS13_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25033">
        <property type="entry name" value="VPS13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037235">
        <property type="entry name" value="VPS13_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="VPS13-like middle region" evidence="8">
        <location>
            <begin position="1132"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="9">
        <location>
            <begin position="1981"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="10">
        <location>
            <begin position="3076"/>
            <end position="3179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1572"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="415"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1575"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1592"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1613"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="3207" mass="360012" checksum="5B18E6C1D7418814" modified="2021-02-10" version="1">MLEGLVAGLLNRFLGMYVQNFDPTQLKVGIWSGDVKLRNLELRREALDQLKLPINVVEGHLGELTLVIPWSNLRGAPVKVFIEDVFLLASPKEEAEYDEEEEERRRQRLKLEKLDSAEILKERNREGMSQEEQKKSQSFTQSLVTKVVDNLQVTVKNIHVRYEDSISAPGHPFALGLTLEEFSAVSTDGQWKPTFIQDSSTTTHKLATLGALAVYWNTDSDLFGSGREASSPLKEPLSHDEMVQKFKGMVGKANALASNHQFILRPVNGQAKIEIDKSGDIHTPKFKANLLFEEIGLVLDDDQYRDALMMVDLFHYFIRHQEYKSLKPKGVRPKEDPRAWLLFAGNAVLNKIHERNRKWSWDYFRERRDDRQRYIELFMKQKQQQQFTTEESEEFRKLECKLEYEDLRFWRSLARNQLKKENAEALRKQPQQQQQQQGWLAWMWGSQPQGTIEENEENTQMTEEQRKELYEMIEWDEKQALAEEVDVPREAVKLCLEASLSTGSFTLKKSPHDNPSDLLSLHFDVFKAKALQRKDSVLANISLGGLRVNDGTTPDSLYPEIVRVKDAPEVRKRKSLSLKELEIDKEEPFFQFEIEKNPIEREGDFAIVGKLKPLEVVWNPNFVVGIVDFFRPPERHMESITALMESAGATVEGIREQTRAGLEFALEEHKTVNAELDLQAPLIIVPVSITTANSTCLIVDAGHIHVNSQLVDNKTMNEIQSKQRQSYSEADFQRLESAMYDKFIVKLTSTQVLIGPSIEETKKQLVKKSADSQLHVVEKINVDFVVETSILPKAPNLTKLRVSGHLPMLHATVSDSKYKNLMKVIDAAIPKLGQSQQPESSSENSQTLQQRPRLLSANSTRSRRRSQRERRQSSAFPFMQPQSAVILEDIDDDEDDFEDATDGVDGQQLKIQQRSFEFNFKVDTLKGSLYRSDPDRVKPDTLLVELVAERFDLAFYTRTYDMAAEVSLGSVAVEDFVENPPGEFKSIVSSGDSEDLKAGRSLVHVKFMKINRQSPEFMPVYEGVETNITAVISTINIVVTRKTLLTLLDFILITFTGGNNDQEAPSAPTIAAGEGSDEPQLEQSIVDAPKPNGNVGSIRVKVDLKAIRLILNNDGIRLATLSFNHGDAGIYISGKAMRISARLGDLSLVDDVNLGVSADSSLRKLVTIQGDDLADFRYQTFDPENQKAYPGYDSSVFLRAGSVKVNFVEEPFRKIIDFLVKFGKMQALYNAARQAAVTRANQIQQSPSRIRFDVVVKTPIVVFPRLYVSERDKGDAITAYLGEIYAQNKFVPLDDSKNSDIAMKISAGIRNVRLTSDFHYSEDRSEELEMIDGVDLGFNITYVEHKEGVKRPDTEIEGTLSDIKLRLTQYQLKTLMEISKSVPAALAGEGDDSDEEAARMVDEGTLQRARGAPGNGNNSHDQSLIDLSPELSSLQNAWTKLDLIFQVNTVALELIMAEEDEPVGDLAKSSLSRFSLDDTRFKTRMLSDGSLEAELLIQSFTIQDSRRQETKYRRIMTSSNKEAQQLMASVTMSGGKERSLIAMATIDSPRIIFALDHLFAIQKYITEGLAVDDTSPMDDESIGETVDESDTDSMQVTYNAPGTERTQSHASRQRNEVSPDKSQKQKEESTMSMAFRVNLVDAQVILIADPLSSSSEAIVLSIRQVLLSKQHALTFQISETGMFWCRMDKFDTSRLRIIDDFSIQLNMDNSQVGVTGIHIDVEPLILRLSLRDILLILQIISRASELSGNETKHPPETAAEQKARELRNAGLKYKSASGRGQSTIAKTRGTKTITGRTIHPPTKPQPATVPDREELSATIDGVRIVLIGDLHELPILDIGVNNFTATAENWSSNLKAEAAINMYSSVYNFAKSSWEPLLEPWHVGLGVAKDPTSGLISVDVASKKTFDITITTASIALASKSLTFLTSEQNVLDKPRGVEAPYRIRNYTGFDVVLHSKSPSSEEPISLRLEDGAEQPWSFEHWEKMRENLLTESSQDGVGIQLEGSGFDLIKSVKLNREGEFLYGLRPKTENILHRLCVEVKLGSDNVKYVTLRSPLVVENATEIPVELGVYDAREGHLLKIEKIAPGDSRPAPVGAVFEKRALIRPDGGFGYEWSRDQLWWRDLLQRPTKQLVCNGENGDPFYFQAHAQFDRSNPITKIYPHMKIKLSAPVTLENLLPYDFKYRIYDKNTKKDWSNFLRKGGVSPVHVVELSHLLLLSIDMQDTVFKPSDFSIINSGNVEDFRKESRIVVKDDQGLPLNLALHYFKIPNSGGAFKITVYSPYVVLNKTGLDLRIRMKSFLQQAKPAAGQFPLVDTSDRERPKALPFMFSYGNDDNRNRALLKVDESEWSKPQSFDAVGSTSEVVLNSASKTKEIHVGITVKSGEGKYKMTKVVTLAPRFVLENKLGEEILVRESSSSGYMTLKPGALQPLHFMQKSAVKQLCLCYAGVDNHWTSPFNIADIGTTHVKIAKAGQRQRLLRVEILLEDSTIFLHLSMETKNWPFSMRNESDTEFTFYQANPNVDEDDVEDGSGWRPIRYRLPPRSIMPYAWDFPAAKFREVVITTNNKERHVKLAEIGNQIPMKFITASGDQKIIDINVAADGPTQTLILSNFRQSRSMYRPKALSRTTSGPEAFEVKDQDTGATFRAQLKLSGIGISLINAQLKELAYITFRDVQLRFSDSPLIQTVSLAVQWMQIDNQLYGGIFPMVLYPSVVPKRANEVDAHPSLHAMVSRVKDESYGVTYIKYASILLQQMTVELDEDFAFALLDFSNVPGASWSKVEQEGKLCDEDLDIPEPSQQQGGQDIYFEVLNIQPMQIDLSFMRTERINAEDKTSSRNPIMFFVNVLTMAIGNVNDAPIRFNALILDNVRVSTPVLIQNISNHYSQEVMFQLHKILGSADFLGNPVGLFTTISSGVTDIFYEPYQGLILSDKPEEFGYGIAKGAASFAKKTVFGFSDSFSKFTGSLSKGLAAASLDKQFQDRRRITKARNRPKHALTGVTAGANSLLTSLASGVGGLARKPLEGAEQEGAFGFIKGVGKGVLGLATKPAVGVLDMASNVSEGIRNTTTVFDGQELDRIRFPRFIPNDGIVRPYNSREAMGQYWLKQVDNGRYFDEQYIGHLELPKEDMVVMVTFARILLIRSKRLTSEWDVPLKDIQTIAKERTGVSLVLRGGANGPFIPVGGGSERAYLYKMIGVAVEEFNRRFRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR07</accession>
    <name>A0A7D5UR07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRPT1</name>
        <name evidence="8" type="ORF">G6M90_00g013760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549146.1">
        <property type="nucleotide sequence ID" value="XM_014693660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR07"/>
    <dbReference type="GeneID" id="26238590"/>
    <dbReference type="KEGG" id="mbrn:26238590"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="31057" checksum="9A30507DCB54E2A4" modified="2021-02-10" version="1">MASHEARIHLQEEAIPRSSRPSGRRGGRGGRPEGREVQLSKALSRLLRHQAENAGIKLDEEGFAPLDRVLSWGPIKSLSPSLQEVKDVVETNAKKRFTLRPADPLAPEAPSAAGYLIRANQGHSLKVDEAALFEPILLGAADLPGKVVHGTYFAFWKAILESGGLKPMSRGHIHCSDRTPEEGAVSGMRRDAELLVEIDIEASLKDGVTWWRSDNGVILTDGGEGGVLETKYFKMVTSRTADLGVLWEDGVKIADLPADLKFRAPEGKRPGGRRGGGEGGGGRHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URS5</accession>
    <name>A0A7D5URS5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium permeable stress-gated cation channel 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CSC1</name>
        <name evidence="12" type="ORF">G6M90_00g019430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548598.1">
        <property type="nucleotide sequence ID" value="XM_014693112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URS5"/>
    <dbReference type="GeneID" id="26238042"/>
    <dbReference type="KEGG" id="mbrn:26238042"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="26"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="219"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="439"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="867" mass="99459" checksum="6D7560613DBFA09E" modified="2021-02-10" version="1">MGPENNGCSREELIAPRSQTINDLKLQLVLSLVLGVSAFITFCILRPRWPSLYAARERRLDPKINLPALSNSFFGWIPQLYRISENQILAAAGLDAFVFLAFFKMAIRLFSIMAFFAIVVLEPINISYRGNETWLNPNKPEHDGRDRDLFGSSQILYGNGLDVLKDNDEDKSNEKPYLWAYVIFTYFFVAVTLYSINWETFRIVDLRQRYLGSQSTVTDRTFRLTGIPIKHRSEEKLKDLIEKLDICLVDSITLCRDWKYLDQLVRHRDLLLRKLEASWAKYLKIQESSTQHSDATQTQNVDDDTVGQVRGINRDEESAENARLLSSQQDQPYMFAGDRPQVSIRYGPLLLRSQNVDAIDYYEEKLRRLDEQIVQARKKEYEPTDMALVTVDSVASCQMVIQARIDPRPGRFLTKPTPSPSDLVWKNTYALRGIRRLKAWAITLFITVLTLVWIFPTAFLASLLSICTIDRVLPKFAAWLSDHTVIRSFIQNSAPTLIVSLLNVSVPYLYDWLSNHQGMVSQGDVELSVISKNFFFTFFNTFFVFAVSRTGFEFFNVLRRFLKDTSLIPRIIARDVEDLSLFYTSFIILQGIGLMPFRILEVGSVFLFPISRWLSSTPRDFAELQKPPKFQYGFYLPTALLVFNLCIIYSVLLNGEIILIFGIIYFGLGYFTFKYMLLYAMDQPQHATGGAWRIICYRIVIGLLVFETVMVGQIASSRAFVQSVAVLPLIPFTIWYSYYFNRRFEPLTRVIALRAIRNGREQNGEGEQAVEDEASDDDGPHFQRQILRRGSTLDEFKERGLTFVNPSLVTPLQLPWIYHDPPALADDDVTTEGDRSSQGRPTLILPNADSSLGIGEDNVWVDSTQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US02</accession>
    <name>A0A7D5US02_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g024580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548124.1">
        <property type="nucleotide sequence ID" value="XM_014692638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US02"/>
    <dbReference type="GeneID" id="26237568"/>
    <dbReference type="KEGG" id="mbrn:26237568"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028950678" evidence="2">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="220" mass="21582" checksum="A735426F8069E085" modified="2021-02-10" version="1">MVRAALPLLAALAGSAVAAETTTVKILVLGDESPFVGSVVNVDSSATTFAVQCPSGTPSDECGLPPGGATITQGESTWQWSLGMSNSEMGVLTQKANCKLDPSKDVAACKIEFTEGSQVTSSEVTESGYKTSMFPVTITAGADKLSASPGASATNGGSNSASETATAKTTQASKTSSTGEAGQPGEAAATSTTGKNAAPAVTQNAVLAGVAAIVGGVLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTE9</accession>
    <name>A0A7D5UTE9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">int6</name>
        <name evidence="4" type="synonym">INT6</name>
        <name evidence="7" type="ORF">G6M90_00g044350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547769.1">
        <property type="nucleotide sequence ID" value="XM_014692283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTE9"/>
    <dbReference type="GeneID" id="26240332"/>
    <dbReference type="KEGG" id="mbrn:26240332"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="245"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="439" mass="49820" checksum="57A7038461CFBDE9" modified="2021-02-10" version="1">MEDILTAVSADGSSIMPKLAPHLSRHLLFPLIQFEGDQAEEKGEDEKAKRILSGKIKLLEDTNMTDYVATLYCELHGTSDPPAEYTKKRQDVLAQLEKYEQATAKIADLLTQDEVVNGLRSDKVANLEFLKNQHGVTMEMVNALYDFGQFQFRCGQYGPAADMLYQFRVLSTDNDKVSASTWGKLASEILSTNWESAVDELKNVKEGIDSKLFNNPRAQLDHRTMLVHWSLFPLFNWEGAREPILDMFFSAAYINTIQTSCPWILRYLIAAVITGRTRARNSSTQQKQLKDIVRYVRQEAYEYADPITQFVNALYIAHDFNAAREALRQAEDVCRSDFFLASSADAFVNAARHLICESYCKIFSRMNIRDLSAKLGLNPDEGEKWIVNLIRETRLDAKIDSQDGTVIMNHPPNNVYQQVIEKTKGGFFRTQVLNAAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTK0</accession>
    <name>A0A7D5UTK0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PHO8_1</name>
        <name evidence="13" type="ORF">G6M90_00g048480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544963.1">
        <property type="nucleotide sequence ID" value="XM_014689477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTK0"/>
    <dbReference type="GeneID" id="26242304"/>
    <dbReference type="KEGG" id="mbrn:26242304"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.140">
        <property type="entry name" value="Alkaline phosphatase, crown domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042085">
        <property type="entry name" value="Ap_crown"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028895950" description="Alkaline phosphatase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI66694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="505" mass="55019" checksum="111BEB9C9A91C1CB" modified="2021-02-10" version="1">MLLRAILTLLASALSSPAFAAPAGKVRSHRVRNFIYVVPDGFGPASQTLWRDYISIMNKNGTELRPNSTATDLDGIMIGTVRTQSFDKFVTDSAAAATAFATGHKTHNTGIGIDSDVKPVASILEAAHLEGFKTGLVVTSRVTHATPAGYCAHVMNRSLEVEIASHQIGQKHPLGSVVDLIMGGGRRHYQTKRPGGNSTIDLITWAKGQGFSYAGNKRELEVFSRDLGKVPLPFLGLFADSHMAYELDRDNEKEPSLLQMTQTAIKTLSDATTAGRDGRDGVSRPKGFFLMIEASRIDHAGHANDIAAHIHDIAMYYQVMSFLRKFVTENPDTQILSAADHETGGLTLGTGYNPAMLERANHTSEYLERAFALYQGPDRATYLRNVILPQYGLVSASDKDVKKYLDVLKRDGISEMGSVIRRDFAKSAGITWATDGHSAVDVPLYGFAVGDKAYSQMKEYLGPHTDNTQLALYMESALGVNLNKATEALRENWVKFEGYGGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTQ1</accession>
    <name>A0A7D5UTQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028800094" evidence="1">
        <location>
            <begin position="18"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="108" mass="11555" checksum="A6C989FDE3B91C86" modified="2021-02-10" version="1">MQYPLLLVAAFATASIAAPAAGPPASTQGKEDVTKEVGKLAEEACPRDQLVYSSRGGLLLRQEDCKRYADKCLQGGIIEPAKLKECINDARIKSKKPAQCPKEPAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTS7</accession>
    <name>A0A7D5UTS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">54S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">MRPL10</name>
        <name evidence="6" type="ORF">G6M90_00g041210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI66636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691981.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26240030"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="114"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="32252" checksum="45E3F4B9CA6B311D" modified="2021-02-10" version="1">MPPRLLPSSSSICCRTTSPAPVGYLTACLAGLTIQQTRNASILGSLANNKGAVHIKKRVGRGPSSGHGKTSGRGHKGQKQHGKVNAWFQGGQTPLVVKHGRMGFTNLRAPKMSEVNLDQIQEWINQGRLDATKQITPKELIQSKLVGSVKDGVKILSRGSECLKQPIDVMVSRASAGAIAAVEAAGGKVTTRYYTKLAIQRLLRGESVNTDMPLPVGKEHVDTVLAEARNAPFRYRLPDPTSRRDIEYYRDPAHRGYLSYQLTAGQSPSLYFKVPGERKIKSAAKAEKKATEETLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTZ6</accession>
    <name>A0A7D5UTZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C6 zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g022090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548344.1">
        <property type="nucleotide sequence ID" value="XM_014692858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTZ6"/>
    <dbReference type="GeneID" id="26237788"/>
    <dbReference type="KEGG" id="mbrn:26237788"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51213" checksum="8CDD9615472ACF29" modified="2021-02-10" version="1">MLPATSSALSIPRPLLADISGTEIERFYFHCFRAVAGEAVGIRHKYNSLFWKESVPQYCYAVESMKHAFIAFGAAYHNFQTTGERVDPTAPPSKTERFIIQQYSLAMSGLARDTQQVDVRRRYGITLISCIAFFCIEMLRNDWKAALTHLSNGLQLMANLPEEVSDVLQNPEKWNQGSNNSHVRVLYLFRLLSRWEVAMRLVTGDFRPRLTLQTYEARKLDASVGTKFSSVEDIYEAVDSYCQDASAFTWLTRGHHGDTQFWAQHYTKLQHSVLMERSRLIGNNISLYQNNPDMKTLEIQDIIFFNACRLRHKGATLILKMLPLPEKPDGSHELEEITQFEDFIRAAISLRDILTGSATEKLTGDNANVDLAVVPTLYVTGSSCREERLRKKILGLAMEWPRRENLWDGPALRHMFDINGIRSSEVRKLVTESGSETVQWSGCPPGMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU55</accession>
    <name>A0A7D5UU55_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein MLH3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MLH3</name>
        <name evidence="4" type="ORF">G6M90_00g031700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986195.1">
        <property type="nucleotide sequence ID" value="XM_066130090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU55"/>
    <dbReference type="GeneID" id="26243909"/>
    <dbReference type="KEGG" id="mbrn:26243909"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="616"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="854" mass="95802" checksum="05F795D57AC523B4" modified="2021-02-10" version="1">MSIRPLPKDVVDRIKSSSAITSLNQVVCGLLTNSLDACCTKVNISLDYVLGNCTVQDNGLGIEPSEFEQDGGLCKLHHTSKSPPNPNIHGSHGSFIASVATLSLLTATSHHRHHASQASLSVHNGKVLARHVPALPDQRFELFSHGTRISIRNLFGSMPVRVKQRGLLFSDRVRLAREWESLMRDIAGLLLAWPTEVSISLREANTQWEQRLRSGNNEFVSRISRIFTQSGLAGSEDAGSWVPVSASCRRVRIKGAISTNPVATRRSQIMSLGIRPIPNSFGTNVLYEEANKLFQGSNFGVVDTEEHIGGIQGKPRKGIERWPMFYLEIHLLGTDEDLAMEDVLGDSKHSLQAIIDLLKVVCYGFLKKHLLQPKQIQRIAEVPVTARTRHPPRRLTGQSISEGQKCSRLPSAATPEPEPRRPCSPFDAWNRLKVGRAVAEPKVAYQSVESPATADKPTTRRLVGDRGVLLQRPFDDAAEIEPSVQSPHMNEPEVLVEATTEKNNTKSLEVDSKAETSSPKTRLTRQVEQISEGRPKAQPQEWLQNIIRSWKNPVFELTEPRIPSLDQAIPVERPVNANYDGPCSKFYSQEYHVQFESAAMALDGRLSRTSLAQAEVIGQVDKKFLLLRLPLHTPNVAQGTEASSTLIMLDQHAADERCRLEELMSQYFQLNPLQAVTELLEKPIVFEVSAREYELLGRFHSHFRTWGIMYVMCKTSSMNEHQIEIKSLPPSILERCRTEPKLVIDLVRKEIWKLEDRTIPPQPVYEPGKPWVSSFHNCPQGILELLHSRSCRSKVTTNTIIFVQPANNSQVPSCLMMSSARTNASEWSNVYRDVPFHFSVRTGARAWYRWSISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUC2</accession>
    <name>A0A7D5UUC2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-pipecolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fap1_0</name>
        <name evidence="8" type="ORF">G6M90_00g038890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547245.1">
        <property type="nucleotide sequence ID" value="XM_014691759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUC2"/>
    <dbReference type="GeneID" id="26239808"/>
    <dbReference type="KEGG" id="mbrn:26239808"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="672" mass="73822" checksum="BFFC1061F930BE4B" modified="2021-02-10" version="1">MTKLGHPLGEVNLTKAAGVYGTVQAIFDAGKESQAVFCHVCPHCATLELIFHKIRTSTSVEPAAFLRKSFQMVERLGAKAIIFTVDVGWESKRTLEARTNGEIHKSSLGAFMATGGFRDRNLFWDDISWIRRYTKLPIIVKGVQSTEDVELCVKHGAEGVMIRLQVQIETYRPDLFRKFDIMIDGGVRSGADVDLARLQQMETAPSSFLIVGSGVFGLSTAWAITKRSQFAKTSITIVDDAANGQFPPDDCASVDSSRIIRADYADPHYTAFASEAQKEWRKQGDDDLGGQGRYTESGFVLTAYEPKELKVGTKSGMDYTKESWKNCVDVAARDGYPADRIKVLENTKTLNECLGTDTYPGDWGYLNTLSGWADAGRGMEWLYERVKATERVNFVNAKVDYLANEGDRVIGAKLTDGRLVTSDVVLVAAGAWTGSLVDLRGRVEATGHVLGYIDISDRELALLSKQPVALNLSSGLFIIPPQENTLKVARHSFGYLNPVMVHNALPLFPSPERPSFVTSRPSTSRDGGLARLPDEADADLRRGLAKLSPIKGLETRRWKGTRLCWYSDTKDGDWLVDWHPGWKGLFIATGDSGHGYKFLPILGDKVLDCMQGQGGALGDKWKWKNIDDETVGKETNGKFKGLVTMDGSRGGDPGMVLAEELGKKSAAKVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUJ7</accession>
    <name>A0A7D5UUJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TBB</name>
        <name evidence="17" type="ORF">G6M90_00g037250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547086.1">
        <property type="nucleotide sequence ID" value="XM_014691600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUJ7"/>
    <dbReference type="SMR" id="A0A7D5UUJ7"/>
    <dbReference type="GeneID" id="26239649"/>
    <dbReference type="KEGG" id="mbrn:26239649"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI66899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="448" mass="49987" checksum="21498C9BCF3447CA" modified="2021-02-10" version="1">MREIVHLQTGQCGNQIGAAFWQTISGEHGLDSNGVYNGTSELQLERMSVYFNEASGNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSNPSYGDLNYLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVSVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGKVAMKEVEDQMRNVQNKNSSYFVEWIPNNIQTALCAIPPRGLKMSSTFIGNSTSIQELFKRVGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDAGVDEEEEEYDEEAPVEEPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUL3</accession>
    <name>A0A7D5UUL3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Fatty acid synthase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">FAS1_1</name>
        <name evidence="19" type="ORF">G6M90_00g051940</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539501.1">
        <property type="nucleotide sequence ID" value="XM_014684015.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247726"/>
    <dbReference type="KEGG" id="mbrn:26247726"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000006">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="18">
        <location>
            <begin position="1772"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1324"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="16">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="16">
        <location>
            <position position="1911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI67230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2150" mass="238642" checksum="A5180A925F755E20" modified="2021-02-10" version="1">MDVSAAITEPPTPFWSSTDTATGSENTDSSPSSLIVVDPSKASQHITLEHGDFSYRWNVPKPHYSYVLRSKEQFLATISAGDEEETSFSSNVELVSRFLLHLIEQDELDGCKTSMKAREECIEALLWRLETDFLRGADIHTLACQLPGNAKQRQVVIQAYTAAMVCTKREDNRAELETALFPSSTEKTTRTYAIFGGQGNTLDYFGELRTVYKTYRPLIERFLIVAEQTFQDILANASAARTRQYCRGMAILQWLREPQSTPDQDYLLSAPVSCPLIGLLQLVNFAVICRCLRESPGDILSHLSGMTGHSQGVAVAAVLATVTTWDSFDAALVKALTILFHVGSAAQGATSQVTISSNISAETVKNGMGLPSPMLNVVGCRLEQLETYINDLNIRLEPHQRVFIGLKNGLLNFVVSGPVLSLYSLSCMLRKVKATPGTDQSKIRFSARKPDFSYRFLPVSAPFHTSHLHCAQEAALRELDTLQLATSELKLPVHHSSNGIDMRTLKKQNIVPDLVQMILCELNDWPLSTAFTNATHVLDFGPGGLSGVGMMLHRNQEGTGVRVIMAGLAEGKSIECGYRSEIFAKKVTFSENWNRVYSPSLIQPTTTDMHIENRMTRLLGLPPVMVAGMTPTTSSWEFVSAVMNSGYHVELAAGGFHNAEQLITAINSLIHSIPAGRGICVNIIYASPKQVRWQIPLLQRLRSEGFPIDGLTFGAGVPSVEVAREYMAMGFRYLSFKPGSAFDIDQVIAIARLDETYPILMQWTGGRGGGHHSFEDFHDPILKLYGRIRRCSNIILLAGSGFGGAADTYPYLSGTWSTSFGRPPMPFDGILLGSRMMVAKEAKTSQGCKEAIVAAPGVKDESSWEQSYNQPTGGIVTVKSEMGQPIHKIATRGVLFWKEMDEKIFSIADKSKRREKLQEMRSYIIQKLNNDFQKVWFGRDDMGNCIDLEDMTYAEVLRRLVQLLYVAKESRWIDMSFMRLTADFTRRMYSRLLPSSPSIETYFGLRDPQKAVPNIISQCPTAATQVISYSDARYLVLLCKLPGQKPPPFLLDMDDDFEVWFKKDSLWQSEDLAAVVGEDAGRTCILQGPVAAKYSTRVDEPVGEILDSINRGLISNIMKDRYSDNVACVPQSQASSTVPWTAPFTPRHCFVQYEGKKTRYHLAKSIESEQLPDTEKWLQMIAGCSGTWLHTFLTSSVVSQGSKIVANPIRRALSPIKGMLVEVTETGSPEEAAIAVFDLKSETSLSSFSRPSLVIRKEKDILATFYTHETVDRATVSVTFKFTYHPEMPLHPIHEIMEGRNERLRSLYYQLWFGADVVDRFPSPRGKKRPSISHVQPCDSIPENSEPEMPQSIQAGFPFQLDRIERNTFSELSDESLGVASLENFIFNNRGLTISSSGIQAFLNNVGHEGHMTSPRGSDEKTAPLDFAIVVAWQAMIKAIFPTAINGDFMKLVHLSNEFKMLGDGAPLRSHDRVSTHAEILAIRNEPAGRVVEVGAIIERDSIPVLEVISQFLFRGSYTDLGVCFEKKVQPKTYILLDTPAKVTVLKSKQWFQLVDSEMDLLGETVIFELKSLTRPGQDSNYLNVQTVGQVYRQHAVTKTRHVIANVHYQCEKTIGNPVIDYLQRHGSSVDVVKQKDAPQPLGDQESLRFTSPATNHGYASASGDFNPIHVSEPFSKYANLPGTITHGMFTSAAVRQLVDKAAGINKNVRMRSYKCNFVDMVLPGTQLEVKVNHTATKHGLRVLSFHATNIITGNKVLIGEAEVDQQPSAYIFTGQGSQTPGMGMDLYTTSEVAKEVWDSADRFFFETYGFMISDIVKRNPKRLTIHFGGRRGRKIRQNYMDMTTDCNGQPRPVFKSITATTTKYTFQHSAGLLYSTEFAQPALTILGNAQFLHLKSHGLVDPNALFAGHSLGEYTALSAIGAIMPFEQILSVVFYRGLVMQSSVTRDANGCSHFSLMAINPSRIRKGLTTETLQTLVSAIAAATGNLLELVNFNVAGQQYVAAGTLPALDCLTYVANYMTTHPTELEPSHLAKGTKLPAVIEMWAEQASKKPEPTQLKRGLATIPLDGIDVPFHSSFLRSEIDAFRSVLHSYIKPDAIDARRLVGKYISNVTGKPFDISYRAVREVYEQTGSEILRSLLTRLCTLQYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV89</accession>
    <name>A0A7D5UV89_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547089.1">
        <property type="nucleotide sequence ID" value="XM_014691603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV89"/>
    <dbReference type="GeneID" id="26239652"/>
    <dbReference type="KEGG" id="mbrn:26239652"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1175" mass="126913" checksum="6B810AFAA9F7CEC0" modified="2021-02-10" version="1">MQTVPSLVGTGTAIAAAASGLVFGQPTDLDLNLNHQAATASSRGARVHQRSISIDRVLPAKSYSPSRTLPPPSRRPATSSAAPRSIGSELHAAGTSIHQTTRPPLSRRQRPQTSQVAPSSTSSRRQSLVVLSQGDIYTGIPVVEGSRESISSSGSWLKRLSSIRPLSQHGSPRSSILADSPSVSFSYGSAAPILSRSGSVSKPMPPNKLVKRSPSKNYTSEELAQRKSKGHLPTLRRPATSHQRSATLQQFRAGLDVAGSSADAKYSFDEPICPEKLLGASPIEELGQSPRTARAAKTSGWVSFFHSKTASLMTKPSSHTRLGGSGDGGDAASSAKNLQSKRINPARSMLPGTGAHLIKPRMVSGSSTQSDSFASSHIEEEPNYQLVSRNGDRVGSPTTGEMVSGMPPSARPRRSFSSTFSQTANWASKTSGSLRRTKRGATQGSGENKRHVSAPVRALPSAVGRVDTMTSTPIAPVQQGLTLDSAATFQRPAPKRNASSPLPPLSNLPGLHAELSRRSPVGGVAGHSIRPNQPSGSSTSSTSVAMTQRRGSHYERLSALDSSDGDARDLISGDEYDTDFKSDTLFDSLRTMGSGRVRAVETPLESVYDESPPSTGGNKRSKRLSIQEILDRTWDEDGKIMEEDESNSTPVHAPHRYMGSHVRRELREDPRFGLDPLTSNEVARETRNFGRFSLDDDFDEDWTRDDDDAPVNALSPPSKGSSLSSSGINPNVRLALASIGGNLNAPSKPRSSSSERPLSNLFDWSEPTPHDKQNPACHSRPKTAYAKQEIDSRGGRPVVRKGPMPAHVRSQSVPVVHDLADESKPAGSKYGTWGLGSKTVSEDWDEDFEFGGLNDGPGGKEPEDLFAVPESIRASQPSVKAHSGQIRELSLLVNDLKRLCRHGRELNMLNGEQKPFWKEAEGIIALASPDEGSANEDGQSEASIYMDAFEAANPPGDEDDIDDNLSFDRLDAVIERNEPVMSKTAVVRERQSPRRRSVFSPDDDIFGANWPLSDDRPRSSRPSRPRTPENPPAKLQDVDGVVRSVIESVQYRSTLATAQPAAQGSRKRDTGTNRMHFDTNSLKLLVRRAGELRDILSDLIRRADQLTQSPARTPRHERRLDSSPAFTRVFDDPGSSPARRPVKSRGNSTTIVERPSSENSPPSSIGRRVPLMTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV90</accession>
    <name>A0A7D5UV90_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545154.1">
        <property type="nucleotide sequence ID" value="XM_014689668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV90"/>
    <dbReference type="GeneID" id="26242495"/>
    <dbReference type="KEGG" id="mbrn:26242495"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF24">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="615" mass="66975" checksum="5F95EDBDE0A3C9CB" modified="2021-02-10" version="1">MSPPMPATAEGFATYPPRTALPPLCLDASTARESINAGEVVNKWIAALSSAIDDKYVAGFESLFVQESWWRDLVALTWNVASKYGPPAISAFVLGSTTGLGELTAVQTPMLGPRLEQLGPATFIQAGFAFTTKFGSGRGVVRLANTGPDEWKAWTVSTQLERLKETQDAGRDGANGPETTPESDELQVLVVGGGQCGVSFAAQLEHMGLRYLLVDKNPRIGDSWRNRYDILKTHTPSAMDNLPFLRYPANWPRHMTKDQYSEWMECYSKIMHLKTRMSTTVKSVVRKDRSYIIELETNGATYTTKARHVVLSTGLHSDQPVQLDTPGQDSFHGQMYHSSRHKSASSVSNLACKNVAIVGAGTSAHDVALDFVTHGAKSVSMIQRGTGLFLTPDSCERTVTALWATPHLSIEDADLIETSVPNVLALTLVSGTTSVCAQMDGDLIGGMERAGMALRKGEDGISLLDLLVLKSGHFYIDQGAAQMIVDGRIKVHRCKGGLGAFYDRGVELADGRRLDADVIVLATGWERTGDVVERLLGRDLAGRVSAREWGRLDEESERIGWWRPSGVPGIWCMSGAISWARQYSRVLALQIDAVERGYNDEYYRETAAAGGRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVP1</accession>
    <name>A0A7D5UVP1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g036650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547056.1">
        <property type="nucleotide sequence ID" value="XM_014691570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVP1"/>
    <dbReference type="GeneID" id="26239619"/>
    <dbReference type="KEGG" id="mbrn:26239619"/>
    <dbReference type="OrthoDB" id="4935761at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI68017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="190" mass="21149" checksum="72F17DC7D985130C" modified="2021-02-10" version="1">MQLSVFGLATLVFYGPLVGYALDLDSIFAEVSAVNRDFENILRVLLRQALRHDDPQTIKEVCKFIESATDNLNTASDKIGFDSNVDDPSDVVAAFCDDMETFTNTQIKAADILVFKAANIWDAMNGAQLPDGIVRLSSAYDKYAGNMIPLTEHCTTKHMQNIYLVKLTLHRVLVDLEPNNGHHRRGTHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW18</accession>
    <name>A0A7D5UW18_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADH6_1</name>
        <name evidence="13" type="ORF">G6M90_00g033010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543230.1">
        <property type="nucleotide sequence ID" value="XM_014687744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW18"/>
    <dbReference type="GeneID" id="26244031"/>
    <dbReference type="KEGG" id="mbrn:26244031"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="355" mass="38345" checksum="C65BB7C50C286818" modified="2021-02-10" version="1">MTDYKFEGWMGLDAESAKGNMVWQEYEPKPWEETDVDIKVTNSGICGSDLHTLRSGWGQTPYPCVVGHEIVGVAVRVGSKAEGGIKVGDVVGVGAQSDSCLGRDGPCNECSHDAENYCTKVINTYASVHRNGGKGYGGYGLYHRCPSHFVIKIPDGLAPEYAAPMLCGGVTVYSPLRHFGAGPGKKVAVAGVGGLGHFAVLFAKALGADEVVGISRKASKKQEALDLGCDDYIATEDDKDWGKHNARRFDLIISTISSEKMPLSSYIDTLRLDGTLVQVGAPEGPVPLNIFSIIPGRRRIAGSGIGSPKEIREMFQLAVDKKIKPWVEKRPMKDANQAIVDLEDGKARFRYVLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWJ9</accession>
    <name>A0A7D5UWJ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g040570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547405.1">
        <property type="nucleotide sequence ID" value="XM_014691919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWJ9"/>
    <dbReference type="GeneID" id="26239968"/>
    <dbReference type="KEGG" id="mbrn:26239968"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="24518" checksum="3F855E2EF4A2094B" modified="2021-02-10" version="1">MAFIRRYRASDFAATAHICRETLPADVSTSQLLRRLAPYIWTHPYTHLSPGTCFVLDDGGGRAVGYCIGCADAEALAAGYDAYVAGVLEPSGEIGPPADGVDASRRLDWVVDGRFCEDALAQTAYSGHWLLVDGNERLLAEGYRATMHIDLLGEWQGKGWGRRLIEAFVESVRPVGMADGAAACKGIWIGVGLSNAKVVPFYEKQGFRVKQREAEGQAITMVRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWU5</accession>
    <name>A0A7D5UWU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986556.1">
        <property type="nucleotide sequence ID" value="XM_066130071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWU5"/>
    <dbReference type="GeneID" id="90967581"/>
    <dbReference type="KEGG" id="mbrn:90967581"/>
    <dbReference type="OrthoDB" id="10382539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="248" mass="28037" checksum="FC10C8CF728708FA" modified="2021-02-10" version="1">MPAADPNEDLECPSSPLSEANNTSSLEALKQLNETCYEEIWAGYDVKRLDIDINQEGKDAICKDISQEYLRCQGETCGKQVLNSGSQCLRYALKFPQQPQKNTKRPKKDTEQPQKDTEQPQKAAEKSAEKFIDLFSKCFQRGVNGTVIIEAAFSEAVGKFNSCQESRTKCDSELRRSANAYLDSKNLSDDINCHRHVSQSIQECRIFLLYNKPLDGSIEQGFRNCVDNRIDDRMKDKECSVEGQNIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXE0</accession>
    <name>A0A7D5UXE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g057390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986749.1">
        <property type="nucleotide sequence ID" value="XM_066130640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXE0"/>
    <dbReference type="GeneID" id="26242733"/>
    <dbReference type="KEGG" id="mbrn:26242733"/>
    <dbReference type="OrthoDB" id="4961353at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028932501" evidence="2">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="354" mass="36317" checksum="0F8DA46B31FB3BE4" modified="2021-02-10" version="1">MKAFVWLVLATTAIAQAMRNGQHGLNRDVEKRSGYLKGLGSRVGLKSGGSDSQYDVNQVKDDTSRGFWTIVGPDGVVNTANAHMLPAASPTGRRKAVDASSNGRQDGQQHSTKGQQKGQRPKQPGMEQQHRNRTQSNNQQPAPKFEGIQITFVTVTVRPTVSKGPVRTGTKSPKTVTTTVTVAGGNPQNSSQKSNTGEKPTPTAGGNGVGVKPVPIDKTALPTTTYSLNPPKPPPPAPPKPESSSSLPPVPAPVALPKPPQPAAPKPDAQKESGTSPSSTSSSAPSSSSSDSQAPPPTAPLDSVVAPVATSPLGVVAPAQPSVNLSGLTLNSIVDLGNLPKQAGNAPAPTTVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXS5</accession>
    <name>A0A7D5UXS5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540441.1">
        <property type="nucleotide sequence ID" value="XM_014684955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXS5"/>
    <dbReference type="GeneID" id="26246803"/>
    <dbReference type="KEGG" id="mbrn:26246803"/>
    <dbReference type="OrthoDB" id="9983241at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029003134" evidence="1">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="41308" checksum="53CACF5995343528" modified="2021-02-10" version="1">MKASTLLVLSASTLSICQSPSSCKGGGKRNGADFVLVDQGVNAHLGPLSKMFANANKQVNVSKVFDDGNHQMSGATTQLSWEKTKDFNDVDTKKWYPQGISSTADAAEVGTYDGKDGWLVSWYSDESHQVRISFVNKATKKYRHALLVNPSADDDFQGVGIHAGGIMWYGDTLWVVDTSNGIRVFDMANVWEVGSGDKVGKISAGKYAAAGYKYVIPQIRWYKWTPSFPFRFSYISLDRTASPDRLMVGEYQPDEKNPIRMVQFELDYTTRTLRTGADKKTAKGVWASCHDILRTQGAVQANGRIYVSRSNGANTNGDIWGWIPGKGAAINKGMVPPGPEDLSYDKRGKKIYTVTEHPGKRYLVTLDSTRIKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYI8</accession>
    <name>A0A7D5UYI8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g074880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986999.1">
        <property type="nucleotide sequence ID" value="XM_066131020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYI8"/>
    <dbReference type="GeneID" id="90967959"/>
    <dbReference type="KEGG" id="mbrn:90967959"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="53400" checksum="D099661A26A86F99" modified="2021-02-10" version="1">METPQARVTALPPVPEPYTNETTPLLPETRYTAVPPRPEYAKWLGETWFLTKASIPIILAYMLQNSLQTTSILVAGRLSSEALAVSAFSYMFAMATAWLVALGGTSALDTLAASSFTASKDKRNLGILLQRGLLVLTAFYAVIVLLWCFSEPLFRMLGQPEHICTQSSRFLRLLAPGGLGYVWFEATKKFLQAQGIYRPGTYALLIASPVNLVLNYLLIHKFVFGLYGAPIATGISYWLSFCLLVAYAAFVKGSECWGGIQLKRAMANSLPFAKLALLGFVHVGTEWWAFEIVALAAGRLGTTSLAAQSVVMTADQIINTIPFGLGVAESARLANLLGARDPVAARRSAHCAACLSVLFGSVILSILLATRYSIGGLFNSDERVIGLVADIIPYVALFQIADGLNGSCGGALRGMGRQWVGALVNCVSYYGGALPAGIYLAFHGWGLAGLWVGQCVALSLVGILEWIIVGLSNWDHEVQKAAGRLGEDSQEHNLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYM6</accession>
    <name>A0A7D5UYM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diterpenoid pyrone biosynthesis cluster protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ2</name>
        <name evidence="11" type="ORF">G6M90_00g072790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545784.1">
        <property type="nucleotide sequence ID" value="XM_014690298.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26241817"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="282" mass="30020" checksum="EB94C7FFC8CE39A9" modified="2021-02-10" version="1">MVSPMPSVGSVVGTSLLFFSGALIMRGAGCTINDLWDRNLDPHVSRTRLRPIARRAISPFNGLVFTGAQLLAGLGILIQFPAPCLFYGIPSLLFVASYPLAKRVTYYPQFVLGLTFSWGAIMGFPALGIDLLSNGSALAAAACLYGSNIAWTVLYDMIYAHMDIKDDAKAGIKSIALKHDSQTKQILTGLATTQIALLAAAGIATGAGPAFFIGSCGGAAVTLALMIRKVNLKSVKNCWWWFVNGCWITGGTISLGLAADYLIQLSDKPTAGDDMDPERCQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYW3</accession>
    <name>A0A7D5UYW3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein Rab-6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB6B</name>
        <name evidence="8" type="ORF">G6M90_00g073340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130984.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241763"/>
    <dbReference type="KEGG" id="mbrn:26241763"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="207" mass="23213" checksum="049C6CADE40B0827" modified="2021-02-10" version="1">MAQAGGSYNNPLKKFKLVFLGEQIGKTSLITRFMYDSFDNMYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTKKWIDDVRAERGNDVIIVLVGNKTDLNEKREVTTQQGEDEAKKNNLMFMETSAKLGHNVKNLFKRIAQALPGMEGADAAAQASSQMIDVKTNTSQPTQEGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ91</accession>
    <name>A0A7D5UZ91_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g073210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545742.1">
        <property type="nucleotide sequence ID" value="XM_014690256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ91"/>
    <dbReference type="GeneID" id="26241775"/>
    <dbReference type="KEGG" id="mbrn:26241775"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35132" checksum="6CF6F5510CF83862" modified="2021-02-10" version="1">MKDFWLYEDAVNTNDIMITDRRQLHDKHGAVCNPHMRLRERKSQLSSLPSGHVQSIKQESEPASHNKQNTIEPRRQGKQQPVPKMKEVASTSNRPAPKTILQSFAKTPISTPPKSTKQMKQTDEPTAALSDDGEPDDTDILSSKSSLALHSKAKSRKDREDALRRMMEEQEEEEEEEEEEEEEEGNKREVIEFASNIEADENPESESLTDAEPESGVPLTTQADKEPSETISNSGNGRRRGKRRVLKKKRILDDQGYMVTIQEPGWESFSEDDITPPAKKPTPPLMPSSSMKAKKTSTKGSQGSIMSFFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZF7</accession>
    <name>A0A7D5UZF7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vesicle transport v-SNARE protein vti1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">vti1</name>
        <name evidence="12" type="ORF">G6M90_00g072160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545847.2">
        <property type="nucleotide sequence ID" value="XM_014690361.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZF7"/>
    <dbReference type="GeneID" id="26241880"/>
    <dbReference type="KEGG" id="mbrn:26241880"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000002">
        <property type="entry name" value="Vesicle transport v-SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="226" mass="25565" checksum="9D10D65511353906" modified="2021-02-10" version="1">MSNPLDTEAGSELFSSYEAELKLVQADLLQKLDQIPELSGDPRKNAVSQAERALEEAEELLGSMRLEKQNIPTSSRAKVNQRFRNYEQDVDSQRRKLKSFSNDHQGYASRYRDEPEGSADAHLEQRQQLLSGTDRLDRSTQRLKASQQLAYETEAIGASTLADLSSQRERIQQTHETLLNSEGYVDRSVKTLRGMARRMATNKIITIAIITVLVLLIIAVIISKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZJ6</accession>
    <name>A0A7D5UZJ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NASP-related protein sim3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sim3</name>
        <name evidence="5" type="ORF">G6M90_00g070030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540672.1">
        <property type="nucleotide sequence ID" value="XM_014685186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZJ6"/>
    <dbReference type="GeneID" id="26246545"/>
    <dbReference type="KEGG" id="mbrn:26246545"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="4">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="493" mass="53454" checksum="5AE2BC82A717A383" modified="2021-02-10" version="1">MAEPAPETRPADEGISTPTVTEGTPAATEDVATPISRDEDPKSRRVSLADLSAKGTALYAHKQYEDAAEIFSRASVMQVELNGETAPENAEILFHYGRSLFKVGQSKSDVLGGPAAADQKNAAAAAAAADSSSKPAAPALTEAQKVTQEGVTIAAGQAGDAHEKKEDKTKEGGPDEKKPLFQFTGDENFDDSSDEEQQEEAPEEEDDDLATAFEILDLARVCYEKQLEQLSKDDEADKGKETAEDPPSVRHIKERLADTHDCLAEISLENERYPNAIEDGRTSLNYKLELYPEDSEIIAEAHYKLSLALEFASVTMSDDEGKNAKREAMDQSLRDEAIKEMSLAIKSFKLKMQNKEVEVATMASPEDNDLARKAIFEMKEVIADMEQRLVDLKKDPIDASDLLGGPQANALGGLFGAALGESATETQARVEEAKKTATDLTGLVRKKKAKEEEKPEPAAPATNGKRKAGDEVPEAAESPKRAKMEDEPEEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZJ8</accession>
    <name>A0A7D5UZJ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Ank2_1</name>
        <name evidence="6" type="ORF">G6M90_00g079130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987191.1">
        <property type="nucleotide sequence ID" value="XM_066131105.1"/>
    </dbReference>
    <dbReference type="GeneID" id="90968003"/>
    <dbReference type="KEGG" id="mbrn:90968003"/>
    <dbReference type="OrthoDB" id="4951794at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="315"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="960"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1328" mass="148438" checksum="37BF3C5ADA2D588B" modified="2021-02-10" version="1">MSEDNSNTTGALTILRDGQAGNDGEPVDVIAINGLFGHHEDTWCEKLSDGTAKCWLTDTLPALIPRMQMRIMTYDYVSDFRIQNLLDESTLHRMAMNLLDAICKLREGRKAAPLVFLCHNLGGILVKKMLWIANCDPMYLEIASSTRLLILFGTPDGSSPWVETLFKIVLASTNPRDAGFEHLHRELLEITQTGPDSLEAATLRFQILGKQYKTFSIYEEVPTDLIGIVVPFPTDKQKQVPCLKTTHRQLCSHRDDRLISSLAKEILAITRIPRPGDYYIFLQYRQSLTMLSPNDSAPGHILAAALPPDTIEWPEWSDMLPQGKQWILPVYGGPGTGKSCFAKQVAEQARCRGDTLTLSYYFSLADHRRRTYRDLLLDLILQLLYQDDAIFESRYVRNVWTYMQSDSYLSAPDLYRFFGAALRKVSKRSVFCVIDALHECDATMSHLIGDFKRLAAGQNTGFKVLITCEPTDSIQSLFDSPGINIERYIKPGKALLSQMVAHDGEEHHGLPILQLQLLKHLTDSGTIGMEMSECTTYNAIYEKILASINATVEWLRDVLLCIAFAHRPMTVGELSIAMGIPTTPGWNAGGLTLQKISILSLKDLQDKLKLALGPLVYLENNTIHIHNTLREFVRGQTDSLPWNLLPTAAAGEVAPSSILPRKCLLYLAMKEMQIPEVEARCGHEETIEGPSGTQFLRYAVVCWPLHLKECIDTMVDVQDWFMPFWKDSETMEWWASTYLSLHLSANFDYSSVDYLVSQPLYLASYLGLTSVVYDMVSQDTIDPSLSYAPTLAIQGSHTKTAEVLLRHKFQSPESWLDALKESCSHGHDPTVELILSLWQESHAQMPDVSELDKCLCTAVEHGHWPVVSRLAQAGARVFKPLEMEHPSMLQRASELGYDGVVSELLALYPRDNGETPEWLDTIRKAMEAAANFGSASVIAVLAPKANLESRSQGKSEPLCFRLTPLHIAAYYGNAEAAEVLLKLGAELESKDDRGMTPFVISCCMNQEDTTRVFLDEGADPNVVIPGTCQARPLHVAAANGWSASVRILLEYGAWQHRATGSPANYTPLHLAVQYANGTRGHVDIVRALLNSFADVHMEKSGDGSTALHLAIKNGSCDEEIIMLLRNRGADVDVLDGKDKSPLYYALREKREYTRLLWADRHSGVTQHSVLFNAVARGLEGRVKQLLQAGIDPDERDKYGRIALDVALGRQIRLLLSPDEPDRMDFCPLLQPERPQIWHTWECIVSVCRTSLTQAKFYHCCLCSDDCGSTETCFNMCESCFNGPRGRFCVEDGHTIRQRFVAEGAISFQELSPNFAQFGPKLGTDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZM1</accession>
    <name>A0A7D5UZM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CEABS</name>
        <name evidence="5" type="ORF">G6M90_00g067140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539580.2">
        <property type="nucleotide sequence ID" value="XM_014684094.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZM1"/>
    <dbReference type="GeneID" id="26247663"/>
    <dbReference type="KEGG" id="mbrn:26247663"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="296" mass="33782" checksum="1890E5A4AE9BEF00" modified="2021-02-10" version="1">MMKWADEHNLLVTDEYRNRVIRTRYGLLAARCYPNAGEELLQAIADCLVWFFLADDLFVDRVEVATDETIRNLTAMVDVLDLNVAGSPPVFGELAWLDVCQRLRRLLQAEAFERFAQGMRLWATTAALQILNHLRPTSVGMREYQTIRRHTSGMNPCTSLADAANKGSVQACEFYDADVQTLVRQTNNIVCWANDIQSLRIEIHQPGQFRNMVTIYAQQGQSLQDAVETTATRVNKEIASFCELADAVTARPISDELHGLIDGLKYWIRGYLDWVVHDTLRYADQFIESDADDRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZP5</accession>
    <name>A0A7D5UZP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g074340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545632.1">
        <property type="nucleotide sequence ID" value="XM_014690146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZP5"/>
    <dbReference type="GeneID" id="26241665"/>
    <dbReference type="KEGG" id="mbrn:26241665"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="71873" checksum="48F4F1A903FD8B86" modified="2021-02-10" version="1">MSSAEQLLIILLRNDRIKDRLFSHLSTSDIASVRRLSSACCNLVTRHLFTRITVTFTPATFTKPTRVAALNRIGHHVEHLTFQMPHSEATFLPPLVHPLTGQEICFLYTPHTSMSSALTRRKYANTELGDILTQQYPPLFHAATNVPSFIHALHSLPNMRHLTVRCPGQDPRERYRRDIVDYALISLRIAVERAPLDKLNKLSLSSLHPSAFNYLRHTQGFGSVPSAGKRWKQVKKLNISVEAWDFHGPSPGLDHLKILDDYVRFFAPSLDKFSFTWIGAKGPCPVALSSDSLFAPPRSSKKLFHEVTSPMSPLPVRPPREPIHFPKLRHLQIRNAAMNAPQLSDLIKSHSSTVKEFDFENVVLTNNGNWEDALAPLSRDDSWTRSSMAAASDYSLVTCESDEELPSPSAAAEAASRELLDLDLGASGFSDEERTVVEGPSEETSAAASAARSEESVGFTTKLRKKRTKRRRRRHDEHGPDSRPSSSHRHDRKPPKPKPKPPLESDRHNRPVTPPSPKHVITAPILAAGPHPVILQPAVYDPSCSQDDGISAVQRNIEQEEAHRLLAEDAAARVSALQKAKEAVLSKLSREFSAKRSKAADAVAACRLMASREWANDMYTTNVVVEDRGRMESRSALVPLMFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZX1</accession>
    <name>A0A7D5UZX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g068610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540031.1">
        <property type="nucleotide sequence ID" value="XM_014684545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZX1"/>
    <dbReference type="GeneID" id="26247251"/>
    <dbReference type="KEGG" id="mbrn:26247251"/>
    <dbReference type="OrthoDB" id="4850586at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="211" mass="22515" checksum="EF1915D9DCAFB2D4" modified="2021-02-10" version="1">MSVVERARTGATAVAEAPDRNSDRKTTRDSSGKRKAQPSAQATAGRITKRKKQTKKDPPIGSARDFPCRPCVTRATKAPGHECASQNNTGAACWDCARNGHTCRPVPAGAVAAVRTFWRLNRQIKDTNGDPDDAWQAAAQNAAQQLRAFGVAAASGAVPALALASHGEAAEKTCEERKLLALETIAEAARLWIRLNKPEDSEDEEGGDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V048</accession>
    <name>A0A7D5V048_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SnodProt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g077190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545382.1">
        <property type="nucleotide sequence ID" value="XM_014689896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V048"/>
    <dbReference type="GeneID" id="26241415"/>
    <dbReference type="KEGG" id="mbrn:26241415"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028925025" description="Protein SnodProt1" evidence="4">
        <location>
            <begin position="19"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14188" checksum="6E18C41BE6B4C851" modified="2021-02-10" version="1">MQFSGVICAAIMAVTASAVRVSWDSGYDRADRSLTEVSCSDGKTGMMPKYQKQGDLPNFPNIGGADAIAGWGSPNCGSCWRLDYDGMSIKVLAIDHAGSGFNIGQTAMNALTNGRAVEFGQVDATATRLTPGDCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1B7</accession>
    <name>A0A7D5V1B7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fusarin C synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FUS1</name>
        <name evidence="16" type="ORF">G6M90_00g081600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543397.1">
        <property type="nucleotide sequence ID" value="XM_014687911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243574"/>
    <dbReference type="KEGG" id="mbrn:26243574"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="14">
        <location>
            <begin position="8"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="15">
        <location>
            <begin position="936"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="2367"/>
            <end position="2444"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="3502"/>
            <end position="3578"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="11">
        <location>
            <begin position="936"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2451"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2464"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="11">
        <location>
            <position position="968"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="11">
        <location>
            <position position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI72270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="3935" mass="434282" checksum="02BB32845907014C" modified="2021-02-10" version="1">MSQNSLVREPIAVVGVACRFPGEATSPSKLWDLVCEKRDVQKPISSDRFNSDAFYNSNGEASGCTDVKRAYLLSEDIRLFDASFFRTNALEAEAMDPQQRLLLETVYEAIESAGLPLEDLKGSDTAVYVGSMTGDYHEMLLRDPQDMPKYMATGTARSILSNRLSYFFDWKGPSMTIDTACSSSLVAVHEAVTALRLGVSTIACAAGANLILGPEMMISESNLHMLSPTGRSRMWDASANGYGRGEGTAAVIMKTLSQALKDGDYIHGIIRETGVNSDGHTNGITLPSSESQTALIRQTYKAAGIDLALERCQFFEAHGTGTPAGDPIEARAIYEAFFNGEGSTCDTAGNIYVGSVKSTIGHLEGCAGLAGLIKAMEAVRRGTIPPNMGFQRLNPKIERFSKNLIVPTEALPWPELPEGTPRRASVNSFGFGGTNAHAIIENFETAQHVQSPRDIIVTPVVLSANSEKSLREQAIQLNAAMQLADESRLRDIMYTLSNRRSQLPLRTFFVGNSAEEVKKSANDALAEDGTFTVHKDEKPSHQPSRILGVFTGQGAQWPTMGREILKESKFAQKVVKTLEQSLASLPEPPTWTLSEQIFADAAASRLSEAEVSQPLCTAVQLMLVEMLRSAGIQFSCVIGHSSGEIAAAYCAGFLSAEDAIRVAYYRGVCAKLAEGSNGKSGAMMAIGLSYEEALQFCNNEFSSRLDVAASNAPASTTISGDEDAIQEAKALLDQRNVFARVLKVDTAYHSHHMLPCAGPYSSLLKECGVRTLSGNPACEWYSSVVCERIDGARHDGILGAEYWRDNMVNAVKFSSAAELAMQSGEHFDVVLEVGPHPALKGPFEQTAKQVSDSTPPYQATLMRNIHDIDALSKTMGFLWSRLGKSAVDFSAYAACFDVLPGRMADNMPTYPWDHGQSFWKESRKSANFRLRTHPPHPLLGVRSSEDMGPEMRWLNILRLNEIPWLEGHKVQGQVIYPAAAYLVMAMEAAKAIDETKLVQLVELYDVRILSAIQLAQSSQGVEISFSLKITEKDDNSSVAEWACYTSSSTNNANWKCHAKGHVRVEFAMPVDGHLPPRNPPDVSLSTLDMDRFYECLADIGLQYSLEFRSLSSVQRRLGYATASVSHIATDFGAIIHPALLDSSFQSLFAAYCWPGDETLNCPFVPTYLKRLRILNIGVPEGEPLVIDSYLTSVNVSDITCDIDIALTDKNKPFVQLEGLTCTSLLRHDPKNSKELYTRTEWEVDVHSEIRTLEVAQSDEQQNLELVDLCERFAYYYLRNLDKVVQRKEVETMEWHYQRVFEWIDYLFPMIEMGKHPTIKPEWSKDQLPWLLEQKSQYPDQIDLMLIQAVGENLPAVVRKQTTMLEHMVKDDVLNRFYKEGLGFQRANGYMSRISRQIAHRYPRMNILEIGAGTGGATKGILQSLGSTFGTYTFTDVSTGFFEAAAEQFSPWADKMIFKALNIENSPTEQGYSEASYDLIIASNVLHATKTLSETMSNVRRLLKPGGFLLLLEVTSDIVRVKMMMSGLSGWWLGGDDGRRHGPTITVPEWDTLLRSTGFSGVDNTFNDFNHSSKYMTSVMLSQAVDERVQFLRQPLSSRGDSTMADSLTIVGGTQGNVSNIIARHLADCHPRLVVQCVAGFEDFASPLNSTAMKSLLVLQDLHEPVLQNLASSTLVGLQKAINQCRQVLWVSSGCRKDNPFANMSVGLCRSLSSEYPHIRIQHIDVETRLDQGTVHCISEAALRLLHWEKLSADTLWSFEPELILEDTKWYIPRLVPDEKLNQRLTSTKMAVQVDTSLKESTVEIFSEASKYLVTQSVPCIEAEQQTPLSTINVTKALLHPVATECHKDYFLCYGYRGSCLDIPVLALTTANASSVSVPEHFVFDLPAVVADGAAVLQRAAFSVLAEQVLEDVDTPGTIFLHNEDQRFSLVVRLAAAKLGLRCIATTSQEPASSTSQSIFIHPHSSHRVLKALIPQNTKSFIDFSTDGVDQSRFRDCLPPTCRFYALNHMVATGSNVSGISVPQAIKALTSPLDSCLLNTVNQVSISELHGQAAARFPYGTVVDFVVESTIARVPPLQSTRLFRCDKTYLLAGCTGGLGKALCRWMVASGVRHLALTTRNISAVDEVWVREIERAGACLKLYQVDVSDINALQAVYEDIGRNMPPVVGVANAAMVLSDKSFGELKTDNFDIVFGPKVRGTQNLHDIFKGQALDFFIMFSSLASVVGNRGQSNYAAANLFMTTIAEQRRASNLAASVIHIGMVLGVGYVSSTGTYENTLRQYNYMPISESDFLNMFSQAILIGHPKSNHPCELITGLNRYSLNSDAQQYFWHENMRFSHHYIEEEQRKVSTATRTSVSERLEDARGGEEILAVIEEEFCTKLERMLQAEAGTIKASQSLANLGVDSLVAVEIRSWFFKEADVDIPVLDVLNTGTISELCERAAQSVAAAQLSDAEECGKTDDKSPTLLSANIPASNQSTAANTSVPHSLFEESSRGGSETPSEDMGSSDISLPSRRDFEFERCGRLSFAQERLWFLQKYLQDPTTYNVTMAYKISGPLRRRDFEDAFEKVIQRHASLRTGFYVDADTSLPMQRVYKYPHFRFTHKEGADYEEEYHNMQKMRYDLESGDVISATIIRYTDQEHVFILGFHHVAMDGFSAQILVKDLIRAYGGLTISSGCNEYLDYAIHQRDAGVPVEVSKFWMSEFNTLPPVLPLFDFAECKTRTPLLDYKTKAVERTVPMTVSSKVKILARQLGATPFHIYLAALQALLYDLNSNKDICIGITDANKTDPAYLDTIGFFVNLVPIRFHIDESEAVSELVAKSKKTATNALSNSMPFDVLLDNLQVPRSTTHSPLFQVILNYKMGSTQTVRFEDCQAEILRFQDASNAFDLAFDIENFPDGSASISLKTQAYMYTDLELRFILDSYIRILSSFVSNPLQKLHEVTALSEDEKEKSLQLGRGRQLPDPKLETVAHFFEDWALTQPLKIALREDSGAEFTYRQIQSIVNAFAETLHGAGLGPGSKVCVYCEPGTHILAALLAISKIGGIYIPLDPQNPTERLQLIVNDCEPDAILCDDVTSTLASLLKSAGKSINVTDIDTSATTTCIPDWNKAKGDSAAFVFYTSGTTGVPKGIALTHSNVVHHINSIINFYSIKRGVVLQQAPLGFDMSLTQMALTMMTGGTLVVASSATRRDPSQIASLMYANKVTHTFMTPTLALALIRHGYDALARCSDWEFSLLSGEAFRAHIVHEFRRLGLAGLKLYNGYGPTEITINSSSGMDELDEAAPRDTQNPSIGVTLPNYTNYILDRNMQPVRIGKAGELFVGGAGIALGYLRRDKLNKEKFLPDPFASADNRARGWCRMYRTGDKAKFLPDGRIVFLGRIQGDSQIKLRGFRIELEDISNTIIKSSHGNITEAGISLRRNGNGSDDESFLVAFAVVSHSFDHPEPSAFFKKLLNDLQLPRYMIPAKIVPVDRLPMSSSGKLDQHVLDSLPVPKEEESNRCPLTDTQERLKKLWVEALPPIGATAAIDQDVDFFQVGGNSLRIILLRESIRREFCVSVSVFDLFANSTLGRMAARIGESTDTTTSPETIDWNTETLFDVPVIETCEDDSYKQHRATSDGLEIILTGATGFLGSAILASLVQDARISKVHCVAIRQPLKSLTAEQPIFKSPRVSCYAGDLSLPRLGLSTSDFTQLSANADKIIHNGADVSFLKSYRSLRAINVGSTKEIVRMAALHRIPIHFISTGGLANLTNLDGLPQVSVSSFTPPVDGSQGYIATKWASEVYLENVVTRLGIPVWIHRPSNITGVRSPSGDLMQIIFKYSEKIKALPEIDGWKGCFDFVPVETVARGIVCAIHETGLQQGMSPIYRHHCGRDKIPVAGIREHLETKVGARIDSVGIEEWLSRAQSVGLDDTAAALVSSTFAQSSIKTVPWLRSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1Y9</accession>
    <name>A0A7D5V1Y9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clu1</name>
        <name evidence="2" type="synonym">CLU1</name>
        <name evidence="2" type="synonym">TIF31</name>
        <name evidence="6" type="ORF">G6M90_00g088370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542275.1">
        <property type="nucleotide sequence ID" value="XM_014686789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1Y9"/>
    <dbReference type="GeneID" id="26244789"/>
    <dbReference type="KEGG" id="mbrn:26244789"/>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="5">
        <location>
            <begin position="330"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="871"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="873"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1248" mass="138914" checksum="78F737ED25DD6BD1" modified="2021-02-10" version="1">MAAPEQVPNPTAAGAEAAQKSANPMAVGTESDLDAEAENGAEALINLSIVLPDSNATRMQIMVSSQEQVHEVRQSIIDLPAAFRYTCFHLEYQGNKVNDFISIAEIPNLEPEPEFRLIEDPYTEKEARIHLVRIRELIGAAGDRVDVYQGVLPGLSLFESVARQTQKISGAAQDASPLKDYDFQSAPSLNNLVPDFFEPGPKTVKSVALSSWNPPPCHLRQRGHLLYIVVSTNEGEQFQITSHVSGFFVNKSSNAKFDPYPRASPKGYSAHSLLELITLISPSFSDTFQQLLEYNNQRDPLATFQITNTVPSAPWAVPSPTSALCAHVADPTRPQETLLLSGVENTDTLRDWNEEFQSAKELPKETVQDRVFRERLISKLFADYNDAATKGAVMVARGEIAPLNPTEGRDAQIFVYNNIFFSFGADGVGTFTSEGGDEAARVATGKDVAGVRLVNQLDIEGLFAPATVVVDYLGKRIVGQSIVPGIFKQREPGENQIDYGAVDGKDIVADDERFAASFAQLSKALKVKKHPVWDKDGKRFDLEASVETKGLMGTDGRKYVLDLYRITPYDINWLEETKLQAEKGHSKAYPHRMTVLRPELVDSFARFKMKQWVDAELALRDRTKADEDVNNESKEASDEGKSKTQLDLSDFKFSLNPDAFSGQVPQSDEEKVQLEEDEKEVREAGNYLRNQVIPDLLRELSDSDISFPMDGQSLSRLLHKRGINVRYLGAVASRATDGRLRCLQEICIQDMVARSFKHAAAVYLRDLPVPFTASCISHLLNCLLGYEMNAKPKAEVDTSLKSLYSDSDLSFELVTPGELRVSIEEQVLKRFRYKLEDGWLNTIRKFQLLREICLKIGIQIQAKDYSFDERTKPSYQSTETVSKQSNGQQNGESKDKKKKKKGQETSTVAATLSTVNTVFSPEDVVDVVPVIKHSAPRSSLAEEALEAGRLSIIQNQKKLGQELLLESLSLHEQIYGILHPEVARVYNSLSMLYYQLDDKEAAVELARKAIVVAERTVGIDSAETLLNYLNLSLFLHQVGDSRGALAYSKHALVLWKIIYGPGHPDSITTINNAAVMLQHLKQYHESRLWFEESLRVCESVFGKQSINSATLLFQLAQALALDHDSKGAVNRMRESYNIFLSELGPDDKNTKEAESWLEQLTQNAVSIAKHAKDVESRRIRSGIRFPATVPPEQQPGARSQRMTQPSQIDARSIDELIKFIEGGDQKSKASKKRPGRGNPKRRGQSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V268</accession>
    <name>A0A7D5V268_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coactosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaA</name>
        <name evidence="7" type="ORF">G6M90_00g092660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541910.1">
        <property type="nucleotide sequence ID" value="XM_014686424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V268"/>
    <dbReference type="GeneID" id="26245378"/>
    <dbReference type="KEGG" id="mbrn:26245378"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="146" mass="15744" checksum="AC1894C82CC5B636" modified="2021-02-10" version="1">MSGLDHPDIAAAYDAVRSDKDEANWMLISYAAATGNKLSLSKTGTGGIAELAASLDDAQVQYGYVRVQYANDAESKRVKFVLVVWIGENTKVMRKARVSVESGDVKRILSHHSIAITASDRSELEERDVVAKLRKAGGADYNGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2A6</accession>
    <name>A0A7D5V2A6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g090570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541715.1">
        <property type="nucleotide sequence ID" value="XM_014686229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2A6"/>
    <dbReference type="GeneID" id="26245578"/>
    <dbReference type="KEGG" id="mbrn:26245578"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="73353" checksum="A73F79D7B0FB1526" modified="2021-02-10" version="1">MDTTTHIPELEDALYCTEVMHLRAGKSELVYDRELLKKAHGLGIMATLPSVAEAQRVTSSASDSTESTSREQTFSTISEASTTYLTPHSSIYGGVSPKLSSFDSSINKPHCKALNFASYEKYISQIDTVHEEPRFRKPSLVIDSSGQSIFSVSTRKSISGVTTGFRNRMRLRKKPTRLFDTPVSCFACQAAFNKTNGLKSLPCGHAHCTDCIRDLVIQAINHETRMPPSCCAQPVPADALKQSLDLDVQESFLKAVHQYSTPSESRIFCCSTLCGEFIPPLKRLDPKLPSAVTCLKCQTKVCSTCKQSAHSIGIHCPGDWELLDALKIGGRSSWRRCYRCRKLVELSDSIGPTTCACSAQFCHSCGGVWDSAVGCPNVCNGEEGLARRRKEEEERAAQAKAVREAERQECEERSASHPSMMALRASQEQEKQRLLDFRCSAESSLKARHAAEGIALMNQQVEEEEQLSQKHSRETSHLDDRQIAEELELRQSLEQAEKSIRVRIKHMEAYCDGLGQNPNGSALPPRIVTEQNLRDLGIQYNLRDDMERQHQSKINMMRDRQEKRMEELLEKHETDLQDQADGQRKARDELIDKHKQEAGQFHSIFGERQSRTTARWTLAIEVLCKELQEQDGLKYAVVDAPSWPEDAVPTVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2N8</accession>
    <name>A0A7D5V2N8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g089740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987459.1">
        <property type="nucleotide sequence ID" value="XM_066131362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2N8"/>
    <dbReference type="GeneID" id="90968101"/>
    <dbReference type="KEGG" id="mbrn:90968101"/>
    <dbReference type="OrthoDB" id="4835445at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="108" mass="11739" checksum="67C7EB1183B56DC4" modified="2021-02-10" version="1">MVFAGVLSPNPFITYLLPLALTNPLLMHSILTVSGSHLAYRLAEEAQGANSPSKDLNIANEALVKCIKAWAMDPLPDVASSRDTASLEARIFDSEQKRKAAECLRQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2V9</accession>
    <name>A0A7D5V2V9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540812.1">
        <property type="nucleotide sequence ID" value="XM_014685326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2V9"/>
    <dbReference type="GeneID" id="26246425"/>
    <dbReference type="KEGG" id="mbrn:26246425"/>
    <dbReference type="OrthoDB" id="3554264at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010895">
        <property type="entry name" value="CHRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07452">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00754">
        <property type="entry name" value="CHRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHRD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="188" mass="20058" checksum="FCB8D76B3DF44FE0" modified="2021-02-10" version="1">MKTSVFFTGYISIAAASPLLNIHIGKHRTSGELFQFTSTYSVKVGPRAVVDADNNPTGGLAGASGLFQYGIDSYENIICYNLTLDGFRGEYQSPALTATHIHEAPVGKAGPPRIAFPNPQDSQGGRRTSIGCLRGPFLTGVKVDGKDTGQGFHVEQIERNPSAFFTDVHSSLAVPGAVRGQLESRNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2Z0</accession>
    <name>A0A7D5V2Z0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g082130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131192.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26243621"/>
    <dbReference type="KEGG" id="mbrn:26243621"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="302"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="693" mass="76931" checksum="BE360EB8AE390EAD" modified="2021-02-10" version="1">MQLQFARLAIAPHLAPTLQEQTADLETHPSYLTHSEKKIDQIESRLGNIEVLLKNIANPAAPIQFHGDPTAAGNTPQTGSSSIPTAASTGDFDSSDDESAYGGDTGLIAHTTFASEFLESAVKRTSLREVNPKMAAGLNNLSQLVEMQKRRSISHGPRFPLQKPVPPGGISKLPMPPMQAVVSLLKHAKAAPPTLFTIMCSLVGLPDFTGLCRRVYFATEEFSDATFIIVNAMLYNLFMEQNSLATDPMARDEYHAYMSQSQANLETALANTHLFLATRVENVQALLLGALYAVDVSRPSVAWHLSCMAAQLCQTGGFHRSESLKFDPPATAKLKRILFWHVYTLDKGLGLRLGRAPVIHECDIDIPRVFEFDGLGQEDSSTIPTLWIKMSYLQSRIYEQLYSPSALKSPPADLVERARALASECRKFEVEADKARNETYAYLKAVNSSDLVDVFLRGDEVQFQVTLTLVYRVIPAPEGSVSRFCDECLATARKAMKVHQECTKRSTIGGYFRSIYIHWNLLLTPFAPFFVLFCYVIETGSLDDLRLLQEFVDSLDEARDASETIEKLYRLCQVMCDVAGLYVEAKSQQQQDQTMVPIGDEFEMYLSQLGFMPTEDQTMGNTNAAGGPPPLSGQAAQIADWFSGNRNMMGLLEEDLSHIDSYRWMQQQQQQQAAQPQQIVSPQVPLAQQTSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V300</accession>
    <name>A0A7D5V300_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rna1</name>
        <name evidence="5" type="ORF">G6M90_00g101070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546238.1">
        <property type="nucleotide sequence ID" value="XM_014690752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V300"/>
    <dbReference type="GeneID" id="26240661"/>
    <dbReference type="KEGG" id="mbrn:26240661"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="417" mass="45617" checksum="6E5B4594ABF8F245" modified="2021-02-10" version="1">MTVLPKLFTIEGKGLKLDTAADVEPHIQDLRANDVEEVRLLGNTLGVEACKVIGEVLATKKNLKIANLADIFTGRLLSEIPEALSSLLTSILNHPNLHTVNLNDNAFGLNTQAPLVAFLSAHVPLQHLYLNNNGLGPHAGILVADALSELHAKKEAARKEGKQVPDLETVICGRNRLENGSMTAWAKAYKLHNKIQHIKMVQNGIRQEGISHLISEGLVHATELQILDLQDNTFTFTGARALANVVTNWTVVRELGIGDSLLSAKGGVLFAKALAKGKNQKVEILRLQYNDITATGVKAFAAAAKDALPALKRIELNGNKFDEDDESILFLQELLDQRKEKLAGDVINEDEWGIDSLSDLEELSGDEEEEEEEEGVTAEELAEKLVKEAEEAQEEPVVQLKDKEVEALAKKLEKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3G2</accession>
    <name>A0A7D5V3G2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amidase chyE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">chyD</name>
        <name evidence="9" type="ORF">G6M90_00g094090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540774.1">
        <property type="nucleotide sequence ID" value="XM_014685288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3G2"/>
    <dbReference type="GeneID" id="26246387"/>
    <dbReference type="KEGG" id="mbrn:26246387"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051786">
        <property type="entry name" value="ASN_synthetase/amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43284">
        <property type="entry name" value="ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="724" mass="81205" checksum="E5304E96C2CE944B" modified="2021-02-10" version="1">MCGILACCTCPQLIRHTVDSQAAELNGVASVDRRQTQDSEDGRTATKAEIASLSKNLQDGINDIQHRGPDGSGVWISKNGHVGLAHCRLSINDLSTNGSQPLHSDDGEIHAVVNGEIYDHDRLRQECGEKYGYRFSSDSDSELVIALYKIYGCPGLFQHLRGEFAFVLHDDREGFKRTIAGRDRFGIKPLLWTTVSEQVLFASEAKAFMAMGWEPEWDVRGISDCGWLVDDRTIFKGVKKLMPGHWMEVTDKHGVQINKYWDAEYPDKTEPDVRSIDDMVLGVRERLVESVRLRLQADVPVGIYLSGGIDSSTIAGIAADLVKEQNVPIGNEESRRISCFSIRFGEESEYDETAIADRTAKWLGVECFKLNLDEQALSDNFAEAAYHCEHHHFDLNAVGKFCLSEFTRQHGVKAVLTGEGSDEHFCGYPSFATEFLREPDLTMLRSAPSEDLEFGEALCKTAHAETSATWRPQASKSEMAGTMPVNDSSTMPDSLLAWQPPKHVYQEWIHEEYGDEWDSRKTLMASHSNDVLEKLSSKWHPSNSAMYLWNKSILINVILSCLGDRAEMAHSIEGRTPFLDHQLAEYVNALPPSIKIMYAPTEINGVASRPAGSALQSLTEKWILREAARPYITDELYNRKKVTFWAPTNWPKNGPLHKMFSSLLTRETVENLGFVDYEVIERALDAGFGDNTDAASFRIVCYTAGWVTISQKFGIRKATMMEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3L4</accession>
    <name>A0A7D5V3L4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g099870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546362.1">
        <property type="nucleotide sequence ID" value="XM_014690876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3L4"/>
    <dbReference type="GeneID" id="26240785"/>
    <dbReference type="KEGG" id="mbrn:26240785"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028863307" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="215" mass="21647" checksum="3679909F5AF29D8D" modified="2021-02-10" version="1">MKTTVVAVAAFLATVSAQSLCAVDCFQSVVTEHPPLSCKEASMYLCFCKGKDLQNYFAECAYSKCGDNAQDAVNFGVSLCKDMGVPIDPPTRPVNPATSQAPAVTTPATTSNAPVDTAVKSSPENDVTTILNAASTATSVAASAVASTVVPPVQGHSSQASSTIATVTQQPSQTTNQTAAQPTSSGVVTAAGVNLKLGTAMLGAMCVGAAAVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3M6</accession>
    <name>A0A7D5V3M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cct4</name>
        <name evidence="12" type="ORF">G6M90_00g101110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546234.1">
        <property type="nucleotide sequence ID" value="XM_014690748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3M6"/>
    <dbReference type="GeneID" id="26240657"/>
    <dbReference type="KEGG" id="mbrn:26240657"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="533" mass="56990" checksum="22BD8DC3547C0543" modified="2021-02-10" version="1">MSAPAVSAGQSQNATFRDKEKPMAVRSSNIVAARAVADAIRTSLGPRGMDKMIRSGKGETIITNDGHTMLKSMSVMHPTAKMLVNLAGAQDVEAGDGTTSVVVICGSLLGAADRLLSKGIHPSVISESFQRASAAAVEVLHDMSQPITLNDTSALLQAANTSLSSKIVSQYSNLLGPMAVNSVTKVIDVKTADNVDLRNIRIVKKVGGTIEDSELVPGLVLNQPVLKNAGGPIRMEKARIGLIQFQLSPPKPDMENTIQVNDYRQMDKIVKEERLYLLNIAKKIKKAKCNVLLIQKSILRDAVNDLSLHFLAKLGILAIKDIERDEVEFICKSTGCKPVADIDSFTEDKLGYAELVEEAESSGSRMVKVTGAKATGKTVSIVVRGANSLILEEAERSLHDALCVMRCLVKKKALIAGGGAAEIEIAAQLSKQARSLTGTEAICWKAFADAMEVVPTTLAENAGLNSIKVVTDLRHRHEMGEKNAGVSIKSGGVNTNISKENVLQPLLVSTSAIELAAETVKMILRIDDIALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Z7</accession>
    <name>A0A7D5V3Z7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987433.1">
        <property type="nucleotide sequence ID" value="XM_066131183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Z7"/>
    <dbReference type="GeneID" id="90968052"/>
    <dbReference type="KEGG" id="mbrn:90968052"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="97" mass="11379" checksum="EFF7761B35BDF01A" modified="2021-02-10" version="1">MQRDRCQWHHRKASPRLLRYRHEHDSRAAIVDLSAQTRYFRLCQKRQGHHPPKPGEKRWKQTSDVQAGPAPKIEDDMNGRSTESGTHQNDPKDKDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V446</accession>
    <name>A0A7D5V446_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HPM1</name>
        <name evidence="11" type="ORF">G6M90_00g109860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543870.1">
        <property type="nucleotide sequence ID" value="XM_014688384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V446"/>
    <dbReference type="GeneID" id="26243257"/>
    <dbReference type="KEGG" id="mbrn:26243257"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="371" mass="40862" checksum="B220B53058D1915D" modified="2021-02-10" version="1">MSFSFEFSGDDIDANTTNDSAREHFQHQHPQPAGKASAFPIQGKPQLPPIEHDLKTMLFRMPSKIAYSMLDITLDSGETIQLPRRELWDVRVQLMAEEEDGIAHLGEGLGDRDVKTGVYEGGFKSWESSVDLVKALAAQSHLASYLNSSVRIIELGCGTSLPSLAMFQWAMSLQSSSSNQQCSFFLADYNPSVLHLVTLPNFILTWALYHRQSLTELQDAFSLEGELELTPSILEGFETYLCTHGMNLLFLSGGWSAEFIQLLYSTSTHLAGALPELSPVSILLGAETIYSPFALQAFTEAVLAILEREKVVFGSQASAWVAAKRLYFGVGGSLDDFVDKIQKGGTIVTRIREEADGVRRGVVRCMLAPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V486</accession>
    <name>A0A7D5V486_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Itaconate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ITP1_4</name>
        <name evidence="8" type="ORF">G6M90_00g112600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987794.1">
        <property type="nucleotide sequence ID" value="XM_066131863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V486"/>
    <dbReference type="GeneID" id="26246922"/>
    <dbReference type="KEGG" id="mbrn:26246922"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="140"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="970" mass="105617" checksum="BA9FB64DEA5730BF" modified="2021-02-10" version="1">MDGPEDANRGGTRASRRFTTLEGWREVQGGLLVAAGSTVAAMVPNPAYDPEWPLPEDAATDRTRQSRMYFSEKGGAWNHHGQAGLWPNGPTTYATVMKDEGAVQHGQLGVLAEGEGEDDLLEEDVNPPFHVFSRRRKWFIIVTIGVAGLFSGLSSNIYLPSLAAIAKDLQVSLGDVSLTITTYLVVQGVSPLFWGSLSDTLGRRPIYIYSFSVYIVSNIVLSLSPNFPVLLVFRGVQAAGSASTVSIGNGVIQDIATPDERGAFISFYQAIRNFSIAVGPVIGGLLANFLGFRSVFVFLLVTSSLVLATIAVFLPETLRTIAGNGSLRLSGIHQPLIRRFVKEKHALEEPDFMGPRPKVTLATFLRPLVLLGQKDILVSLVFGGTVYTVWSMVVASTTGLFKDLFQLNDLLLGLVFLPNGLGTIVGSAIAGKLMTREFVRSERIYLQRYPSATPPSKNKKDLPPNFPIEHARLRHAPWISALFIVATALYGFTVLPAAQLSIVARPGWIAVPLVLQFLIAATSNAVFAINTTLVADLCPGMGASATAINNLVRCGMGAVGVGLVDSMLGALGAAATFLGLGILTEGRPIDDLPNTFRDAISIAQRFAVRFLWIDALCIVQDSRADWEREATTMGRVYANALCNIAAASSDSPGGGLFRTRDPEELRPGLPTTLLQVLYFTEEQVFWECFVEQKCEAFPYGIPGSVSSKKRDMSNIIYSTQGHNAMSQQGCSISPQGLKTWNNLVQEYSRCEFTKTSDKLFALAGLASIFCDWSRDEYIAGLWKSNLAIQLCYSVWETKLKHPSEYRAPSWSWASLDEHIQFPGSLERATAHISILAANSRQSLTIRGHLSQATFEPKAQHLDGNVVLNINGRHVNACINPDTVDIKTQEVEMLTILTLLSYPTAERGAENPIEVECLVLEPVLTTATETYRRIGILNTYMREGLASLGVCIQKDNSGTLKDVTLSDVNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4C7</accession>
    <name>A0A7D5V4C7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g106070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539597.2">
        <property type="nucleotide sequence ID" value="XM_014684111.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4C7"/>
    <dbReference type="GeneID" id="26247594"/>
    <dbReference type="KEGG" id="mbrn:26247594"/>
    <dbReference type="OrthoDB" id="5153524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="96" mass="11609" checksum="35F51FB90DCB6B7A" modified="2021-02-10" version="1">MHIPDRFYEEIYQRGSHKFLSGAEYARRAALNEEAIIQLESIGYRSRSPTEIDRQRRNRIPYLERKKLRQYPELCGYLDKTDEEEFVRLDEEIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Q5</accession>
    <name>A0A7D5V4Q5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g091110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987529.1">
        <property type="nucleotide sequence ID" value="XM_066131390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Q5"/>
    <dbReference type="GeneID" id="90968110"/>
    <dbReference type="KEGG" id="mbrn:90968110"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="47" mass="5171" checksum="9BFD6A82F686624A" modified="2021-02-10" version="1">MSFDMTTTTASGGAVALIRASFVGRRARSALANVWIFPEEEATEWQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5I2</accession>
    <name>A0A7D5V5I2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bacteriocin-protection protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540320.1">
        <property type="nucleotide sequence ID" value="XM_014684834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5I2"/>
    <dbReference type="GeneID" id="26246914"/>
    <dbReference type="KEGG" id="mbrn:26246914"/>
    <dbReference type="OrthoDB" id="10263401at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24364" checksum="F14292DB079ABBF4" modified="2021-02-10" version="1">MARRSTRLSTKAAPATPIATASKSTPAARVTTKDPETISFPSPTDFNAWLLANGTTTPSGIWLKIAKKASRIPSVSYDEAVDAALCHGWIDGQRKALDGNYFAQRFTPRRRNSLWSKRNVDKAAALAAEGRMHDTGRAEVDAARADGRWDRAYAGPATMRVPADFATALQTNREAGEAFERLGRSARFPFLWRVATAKREETRRRRIDTLVAMLARGETLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V637</accession>
    <name>A0A7D5V637_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">mRNA export factor MEX67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MEX67</name>
        <name evidence="11" type="ORF">G6M90_00g101220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546223.1">
        <property type="nucleotide sequence ID" value="XM_014690737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V637"/>
    <dbReference type="GeneID" id="26240646"/>
    <dbReference type="KEGG" id="mbrn:26240646"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000013">
        <property type="entry name" value="mRNA export factor mex67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="409"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="611"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI73672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="666" mass="72660" checksum="9102E01D068098CB" modified="2021-02-10" version="1">MAPRGPRADAAQRANRGATPRAKATTKGGIQKRRAGVTRTDVDGDLDMDAVGKQAARAMGTETKGPKAKTAKAAPGKSLRGTSATAQAVLKHVQGKNSRLPAASSGRVTRSRGKGVDLHFLRVHGLKQSKAANNQDGGLSDLLIFLERKASSFTGNQTRQIMIKKSHMVGDYVFIGAAKEDADEILKLNTFTFAGAQLEIVESTEDLAGQSKGTRSKEGQELAAKFQSILSQRYIGGANKLLKLDALASDAALVTMGMFENPDLALRSFKGLMVICDELFKTEEEKKEAIESISLANNNINDVAEVETVATTFPHLKHLDMSGNQIANVAALERWKGKFKSLETLYMTGNPIDTTDPSYKTTLLQWFPKLQDINGVRVRTAEQIAEQEAASRPKPIPQSGPDFRDVNGIGENFLLAFFAAYDNDRQGLASRLYDDQSQFSLAIDTQSVRDKDAPAPMGWASYIRVSRNLMKITHQNARVQRLFKGANVIYELWKGLPPTKHPNIKDDLSKWIMDCHPLPGLADPAGQNPMGVDGLIVTVHGEFEEYDEKTNVVGKRSFSRTFVLGPGRPGKEPIRVVSDMLALRAFNALPNVFLAPNQAPVDGSHNTDTNSQHQAMVAELCKQTGMVPQYSEMCLAQVGWEFDKALVIFNEKKAGLPSEAFAVPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6X0</accession>
    <name>A0A7D5V6X0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Highly reducing polyketide synthase gloL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gloL_6</name>
        <name evidence="7" type="ORF">G6M90_00g114010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987851.1">
        <property type="nucleotide sequence ID" value="XM_066131909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6X0"/>
    <dbReference type="GeneID" id="90968299"/>
    <dbReference type="KEGG" id="mbrn:90968299"/>
    <dbReference type="OrthoDB" id="4920000at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="6">
        <location>
            <begin position="165"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="283" mass="30709" checksum="AC6A48100B4DF491" modified="2021-02-10" version="1">MPDVALGHSSGEIAAAYASGAISAEAAMATATFRGSSNVSTDQKGSVAATGLGQRDVSSYLVPGVAMACHKSQSSTTISGDTDAVNEVVQRLKAEQPGVLARLLRVDNTYHSHHMLQYGQSYEEQIMPYVCSRDPLVAQHSSVTWALTSGSRVSREWRFRKHPPHELLGNRIVETAANEPVWRNSLALEDVPWLAGHEVNGQIVLPAAGYIAMVGEALLQLHEVVHESHETTFSIKNLHIASARILKMNSTVELITSLKPIMIDASETTTWYQFAISSFDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V7A9</accession>
    <name>A0A7D5V7A9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g109620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987990.1">
        <property type="nucleotide sequence ID" value="XM_066131787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V7A9"/>
    <dbReference type="GeneID" id="26243281"/>
    <dbReference type="KEGG" id="mbrn:26243281"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="225"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="36696" checksum="8F2082140E24B33E" modified="2021-02-10" version="1">MFGQPVARRLAQQTRTISRLYNPASSPLLHASRRSARRWQHSGATATNSEGAATASNSANTEQAAQAISFADNGKGNVAFASGNSSGGGGLALRKGLFYVMFGLAFSAIGAYGSWHTLKTQGLGFYSDEESLKRFTPEEADVEARRIEDTINNLALVAEQRQRPEMVESRPHLKMPGQYRARSLTGSALTGPGKVPVPAYAWVDKGGKSLVSVVYVGEDLCGHPGIVHGGFLATMLDEGLARCCFAALPHNIGVTANLNINYRKPTPAGSYLVLRAETTKVEGRKAWVKGHIESVAAPGEEPTVYADATALFVSPKFAAVSGTRLGMLDMFKKLMFLIRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YNS9</accession>
    <name>A0A7D5YNS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophosphatidylserine lipase ABHD12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">abhd12</name>
        <name evidence="2" type="ORF">G6M90_00g028650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541301.2">
        <property type="nucleotide sequence ID" value="XM_014685815.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YNS9"/>
    <dbReference type="GeneID" id="26245936"/>
    <dbReference type="KEGG" id="mbrn:26245936"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="122"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="386" mass="43079" checksum="55CB9B88464DB114" modified="2021-02-10" version="1">MAKSLIRTASLAVLGPLALYTVFWSLAVIPFFQRHFLYAHKFNTLFWSDVNEPERWGFAKHQVAPFYLKTPDDNNLYAWHILPLPLYHKHEDQIVQGASSETVPLDITTTESFRLLKSDPKAKLILYFHGNAGHIAQMFRADSYHSLTDTSSYHVVAIDYRGYGHSTGVPSEEGLIQDAETLVNWAMNVAGIPSHRIVLFGHSLGTAVASGAAERFARRGVDFAGLVLVAGFSDLANLLTGYRISGVFPVVGPLAAWPSAVKYLQTYVVDKWHSADRLASIVRNTKKRLRLELIHAYSDWDIPWQHEEILFQAAANATTSGLTQTEFDQFKDKHMKLSPGGDGFSVTVKSNPDTIIRQQLVLHGGHNEIVASSSVLRAVMRCFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRH3</accession>
    <name>A0A7D5YRH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g011400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549382.2">
        <property type="nucleotide sequence ID" value="XM_014693896.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRH3"/>
    <dbReference type="GeneID" id="26238826"/>
    <dbReference type="KEGG" id="mbrn:26238826"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="39"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="620" mass="67690" checksum="2B31597AD0BB65F7" modified="2021-02-10" version="1">MTVPKYKDEVQVILKAVDPKLKSKFCDRHIFLTKDNPKIFIGRSTKRDARLAAGAKNGWFDSAVMSRNHAKIVYLPANNSVALVDVGSLHGTYINDKSINKMQFRRLHQNDRIRFGIPIQKGSETFPPCEMRVSLCHGSQDPKERPVVFKVPDSSDGEDETSDIDEAIETSVSLLQKAGMTLDGPQGIGAIDLTGEEHTDLPDADPEVTMEVPEMSTPEDKEPDELQNRQPSVRWSVEAEELEGNEDTFSQESDSSSDFESHDEDSAESIAAGEEVGNSDWDEKDSWKCSDALHVDASPPIPEADGRGKLIEVLGDATSHLQTSSGRESDTLPPLVITQTSQPGDVHLPSLFDAIPSSSYQSPHLGQNISTESLGAKSGKAEYFEAREHNRRVCFGPEENKENDFPTSFQQLDIAMESSTPYPKHGNVLTTGLLESCTRDSATSALLASGEKFLRTPVGELVEMPPKEDYLDDTSAYTYELSKRGAELVEDVQPPETVNFATGGRKDKPVSDSSPEYSESAPRSVQRSSKRKSDAISELLPNETEPSSSQTIAEPSTRPTEFALNSATQPPDVPRVESSSMDSADQRPAKRFRRVAEAVGYAALGGIAVMSALIATAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRN3</accession>
    <name>A0A7D5YRN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRS6</name>
        <name evidence="3" type="ORF">G6M90_00g061110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542757.1">
        <property type="nucleotide sequence ID" value="XM_014687271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRN3"/>
    <dbReference type="GeneID" id="26244706"/>
    <dbReference type="KEGG" id="mbrn:26244706"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="493" mass="52571" checksum="D8DB923679192177" modified="2021-02-10" version="1">MESLSDTQWDVVISGTGLQQSLLALALSRSGKNVLHVDPNEYYGGAEAALSLQEADDWAARHSGPDATPFAGAQITKESEGLAASRSYNIPLAPQLILAQSELVNQLVSSKAFRQIEFLAVGSFFIYQAAGASSEPTLSRIPSTREDVFSNTTIPARAKRSLMKFLKFVLDYDTESQAELWKPSESEPLAEFLEREFKLDGDLQSYVVTLTLSADGKISVGDGLAAIHRHLTSMGMFGAGFAAVYPKWGGLSEVAQVGCRAGAVGGAVYMLGTGISEVQRMDSDGETNVQVSLANGVVVKSKTLVQSTKETSTDSVLLSRLIAVVNSPVPSVLQVVVEGAPTPCAAVVAFPVGSISTDDGTASGFPIYALVHSSDTGECPAGQCIVYLSTVSSSTSKSLLSNALSSFLNAIPTSEPPECLWRMHYEQVTGTGSFASEDNIGTFDWITSDLALNDSILQYVKKAWQFVGGADEENYMQFEDREGVNDDDDAFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSP7</accession>
    <name>A0A7D5YSP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">OXR1_0</name>
        <name evidence="2" type="ORF">G6M90_00g008320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549675.1">
        <property type="nucleotide sequence ID" value="XM_014694189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSP7"/>
    <dbReference type="GeneID" id="26239119"/>
    <dbReference type="KEGG" id="mbrn:26239119"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="421" mass="45780" checksum="19C609097E5FB400" modified="2021-02-10" version="1">MGSVLNVSDAPTVRVFIAGGSYAGLSVATNLLDLGQGLSPRMFQQPYEHHPNLPRVNWDITVADERDGFYHLIGSPLALADAEYAKKVWIKFQDLPGLQTPQIKFIQASVSSVDCEAKTATTIDSTTKVASTHEYDYFVAATGLRRVWPVVPQSLTRKQYLLEVEEHIHSVASAQHGVVVVGGGAVGIEMAAELKLVKPDVKVTLIHSRDKLLSSENLSDECKDKALELLKEAGVDVLMSHRLASTTEAETANGSPKYEIEFTNGHKMSASVVIMAMSKSKSTATYLPSSAIDGDGYVKIESNCTFSPGTPNAEFHLCAGDLTKWSGIKRCGWAMHSGHYAAQNIHKFLLKKHVGQEPKFAELQEVPPMIGLAVGKTAVASGPEGTVFGEDVMQAYFKHDLGFTICWDWMGLAGRKEDKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTC3</accession>
    <name>A0A7D5YTC3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g016470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985932.1">
        <property type="nucleotide sequence ID" value="XM_066129786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTC3"/>
    <dbReference type="GeneID" id="90967467"/>
    <dbReference type="KEGG" id="mbrn:90967467"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="158" mass="17530" checksum="44A810B2A2635BAB" modified="2021-02-10" version="1">MKLINDLLCHLAPILDEQLIAKLSTNQVNIVAYLRGPWGLVQMARIAAAVKYTAGGINYNRLLRLPSMTGTSRVQMRAHLEALLKVEEINGVKIFLKRVALIQWYMSTLPYRSESGQLSDPELIKHLAVNSSVKKVRNAIESGKGLYNILGGHVPNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTU8</accession>
    <name>A0A7D5YTU8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Hspa12b</name>
        <name evidence="1" type="ORF">G6M90_00g012190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985612.1">
        <property type="nucleotide sequence ID" value="XM_066129725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTU8"/>
    <dbReference type="GeneID" id="26238747"/>
    <dbReference type="KEGG" id="mbrn:26238747"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="591" mass="67327" checksum="E1766E547CB3D8BE" modified="2021-02-10" version="1">MARSHSIIVGIDFGTTYSGVAFARDAEPDRVHFVSSWSSPNLYCFTKRKVPTAIYYDGNSKTPTWGYEVRSEQNALRWFKLLLLDDEHMPAHIKNTKYIRTAKSLLKAENKHVTEVIADYLRLLWEHSLQVIERAIGESMVRLSTFKFVVTLPAIWPAYAQIRMHRAIAAAGLLDKRAAGKTSLTFLSEPEAAALATLHKMYRRPDIKRNDDVVVCDCGGGTVDIITYKILRPLLLSIRESVPGDGGLCGAVRLDEAFGRVLKSKMPREVLEALSREEWQRILNDNWENGIKPGFTNNNKSWTVRIPYCASLADVGHPQDIILGRDDIWSVFKDVLGEVASLVLGQIREAHRKYRRPPKYVLLVGGFGRSRALYDYLQKEIRLKFKSIQILQDEGNDPWTAICEGAVINGLKKEQSQNSAQHSLVDSRFARASIGTTYNALPFDEDIHDINDKEWCPVQQDYQASDQIHWFIYKGEVVNGNEPAVFDFFQALTEQPTEIVNEMVYSLAETPPNRFDHTVRLLCRMRWSYIPDITVLPEKTNDDGHIFYELPYKIEMVTQGISQDFQVFYEDKIVAAHSVSESLKTDVVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTW5</accession>
    <name>A0A7D5YTW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">scu</name>
        <name evidence="6" type="ORF">G6M90_00g025860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547996.1">
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    <dbReference type="GeneID" id="26237440"/>
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    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
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        <location>
            <begin position="6"/>
            <end position="196"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="27232" checksum="FE5E2DE7B90858F0" modified="2021-02-10" version="1">MKIENRTFLISGGASGLGKACALELIKNGANVAILDMNEDGHELVKEVGSSAKFFVCDVLNTESITKAVQGTAEWAKASNKPIGGVIPAAGVSTPATILDRDGAAFSLDDVDFVLGVNLRGTLDLVRQGVAEIAKTEEGPDGERGIVIMVASSAAFDGQKGQISYSASKGAVAAMTLPMARDLARFGIRVVTIAPSLFETRMTSMMSGKVRKSLEATFEFPKRSGQPEEFAGLVKHSIENVMLNGTVIRLDGGSRPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUT2</accession>
    <name>A0A7D5YUT2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g093210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131434.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90968125"/>
    <dbReference type="KEGG" id="mbrn:90968125"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028844612" evidence="1">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="127" mass="13218" checksum="99768DE7A1E99CE6" modified="2021-02-10" version="1">MQYHLALALATLAGASIAAPPASPEQSLATKVCPGTNPHESYPMIDVDGLGYRVSNKRCLELAGECRQDGTAEQLVECITKTIAAGGSSEARAEISCSPRADTMKAEGIKCKTDGKKADGKKARGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUZ0</accession>
    <name>A0A7D5YUZ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685422.1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="170" mass="18948" checksum="574FB35BDE7FED63" modified="2021-02-10" version="1">MEQCVPNAQDAIQTGHYVPSAERGESDSRDIPTRDIMDPLWATDKAATGNDPIWDTDNDIDLEADAEVQIREEIEEITSSGMMRMDIPPKATAFERLEHLGRAIPSERDSEGRAIDTAAQPEQFITLDGNPEPLIANRRGDKFEDTFTPDFSPKDLPVSLPLGERRTRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV38</accession>
    <name>A0A7D5YV38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cadmium resistance transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g046470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544773.1">
        <property type="nucleotide sequence ID" value="XM_014689287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV38"/>
    <dbReference type="GeneID" id="26242114"/>
    <dbReference type="KEGG" id="mbrn:26242114"/>
    <dbReference type="OrthoDB" id="3791566at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004676">
        <property type="entry name" value="Cd-R_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03596">
        <property type="entry name" value="Cad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="32912" checksum="4FA5CC09CDCF4A14" modified="2021-02-10" version="1">MQFGKAIGTACSSFAITNIDDIFVLVTFMAEASTTKVLTPLKVTIGQYVGFTVIIAVSMIGFGISLVLPSEPIGFLGLLPILLGLWNVLGLFFPDHEEESEGSRIASMKSIFKVALVTVMNGGDNISTYIPLFSQTKGAEIAVYVVVYYILVGVWCLVAFLVMRQRHVLRVAEKYAHYVVPFLYVGLGIYIIVKSNCYPWTIRRIDAEREGHPGSIIMGVVTTGLLLMCIAAMLWARMRKKRRSTAVDEAGTVLEEVPAPSARQSTEAQQAREAAEAAGEKKSDATPNVQRHDTPQGTSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW55</accession>
    <name>A0A7D5YW55_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MAL11_0</name>
        <name evidence="11" type="ORF">G6M90_00g017340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548796.1">
        <property type="nucleotide sequence ID" value="XM_014693310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW55"/>
    <dbReference type="GeneID" id="26238240"/>
    <dbReference type="KEGG" id="mbrn:26238240"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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    </dbReference>
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    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="490"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI65845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="513" mass="55656" checksum="66FAD50FD0468A66" modified="2021-02-10" version="1">MDAKTSDVQEVEMPMSADDDAARRHDKRSQRLEQELTVATICTRHKLVVWWCFYWAMAAVGWGFDAQINGAMISVPSFRRDFGYTVGGEAILPADWQSAFNIISTVGQFFGGFICSWLADRIGRKSALLIGVAVCSAGCVGEIVSSTRPAFLGSKLVLGVGLGFYLTLAPMMCSELAPVALRGIATAGVNLGIAVGQLISNSVVKAFGERDDRWAYRGPFATQIFFVVFLLALLPLSPESPWHLVRRDKRDEAMRVVARLYGGNDAVGRLEEIDQTIRHEKLQGGSELGLVDCFRGTNRVRTGISTGVFLCQHLVGIIFVLGYSTYFFQLAGLDVSRSFDLGVGVTACGVLGNIVSWFVVERYGRRKLFLFGMVALSALLLLIGIMDVIPSQAAKWVQAASTVIYAFIYFLTIGAVAFTILGEASSTVLRAKTISLATATQAICGLAMNFAVPYMVNPDKGNLKGKVGFIFGALAIIGAIGSWVYVPELKGKTFGEIDQLFAERVPPRKMGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX84</accession>
    <name>A0A7D5YX84_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g085810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541140.1">
        <property type="nucleotide sequence ID" value="XM_014685654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX84"/>
    <dbReference type="GeneID" id="26246129"/>
    <dbReference type="KEGG" id="mbrn:26246129"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="588" mass="65935" checksum="DCCA41F4D140361A" modified="2021-02-10" version="1">MAGASPSPHKPRRKLKQGNGSDKPARARPEALVRAPSFPLAAFMWPARTSSTQWEVLPVILMVVGLFRWAAGLWGYSGFQRPPMFGDYEAQRHWMEVTAHLPISQWYFHDLQWWGLDYPPLTAYHSWLMGKIGCLIEPAWFALFTSRGSDDPTLKIFMRATVIISEYLIYIPAAVVFARRYSRLSGVATWTSSVALVAILMQPATILVDHVHFQYNTVMLGLVLASINSMLAERYKWAAVFFVAALGFKQMALYYAFSVFAYLLGKCVQPRINIMRLTGIGLVTIASFAVLVLPLVIGTLYDRHRGIDSWPDVDGPPPPLPLFPFVAQYLDTRSALYAIIEQMIQMVHRIFPFSRGLFEDKVANFWCAMNVVVKLRNLPTDLLQKAALGATLLSIIPPNLVLFIRPDKKLLPLAFAATAWGFFLFSYQVHEKSVLLPLMPMTLLLAGKQGLNGDTRSWVGFANLLGAWTMFPLLSRVDLAVPYTVLTLLWAYLVGLPPTCWTAPFMEAGPAPKQWAVAIIHSCFYIFMGVWHVVNAIVPPPADKPDLWVVANVGVGCAGFMLCYLWCFWKLLVDSGLVAWQSPKTKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXK8</accession>
    <name>A0A7D5YXK8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">25-hydroxycholesterol 7-alpha-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cyp7b1</name>
        <name evidence="9" type="ORF">G6M90_00g105350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541522.2">
        <property type="nucleotide sequence ID" value="XM_014686036.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXK8"/>
    <dbReference type="GeneID" id="26245772"/>
    <dbReference type="KEGG" id="mbrn:26245772"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="565" mass="64150" checksum="6D17EF3F36AE09A3" modified="2021-02-10" version="1">MTVCKLGITCPPTWVCALAIVIASQLVVFAHQLARFHYTHRSPGNGKIPPKYPFLIPYLGAILPLLRDTRETLTRLTCYNGKPTVARVPMLPGIDVYLYQDPDIIERIWKVSSSLDFRPMAVHFLRNACGLSRESANLYLLDKTGMNAKPLPGTSCPEHPRVYRKIYESDRQALIGPGLDPTLQRFIDAFSRRMAVFTATEWIEMEDFWTCIQHTVAAAEIEAIFGPKFLEMHPDFISLFFEYDRLIPSLLKMLPFSRAERLRSKLHGKFRSWVRRTRKNHAAAPNDNEGDHDPHWGCRWTRYRHEAFQPFFDDDAIASINVGVAWGALANTTPCAMMAIIHTLQDASLHQRLRRDLDELCNGKSLKDVHHKELTGHVLLSAIFAETLRLHMTVLMPVIPLDGELDLGRWRIPRASWGFINAGVAHHNEHVWNTKGGLHRVESFWADRFIVDPADPSSGPSRHQSRHQHAQSRHDDGHGSKPYFSLDGLEGSWVPFGGGRNMCPGRFLAKGVITFALAMMVSQYDIELLTDTIPTGKDRFGIGVELPTRKIPFRIRKRRAPNGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXP7</accession>
    <name>A0A7D5YXP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985917.1">
        <property type="nucleotide sequence ID" value="XM_066129986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXP7"/>
    <dbReference type="GeneID" id="26237280"/>
    <dbReference type="KEGG" id="mbrn:26237280"/>
    <dbReference type="OrthoDB" id="4939479at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="405" mass="43833" checksum="770694B98DC3849B" modified="2021-02-10" version="1">MSAPNEHVNLVTRSVMPASQDETVAESWRMRDGSKSNKKGCSLTEGQQTDGKEATEAILSTPPHQGPENFEEAPAELASTIHELDIGSAQIYKPHTDANPDMGDLIPGQSSGPYSNTSTSPLGIWDTSKDVPASSLLEMWTEEDLLKFGIHEGMDISYGLPLFEENVREYHTAKTALGNRTESYGGINVTFGLPPWIQTNFSDTGETPEKNSNRYHNEHLGAPFAQVSGLSPTPPRKDTDCTALRSVSLSAVGTPTVAESRTLPFSEIKDSAATGDTDIDFPCSRKIPSASERPESSFALRDVSVISWTDCYPEDPDKARELATSTGVPGLQMYSVDVFTHATSDTQVLDEVDATQDSHSFRVEMEPQPNDSVRASSVTDSEGADGSGWVKVEIETENPGQTDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXV7</accession>
    <name>A0A7D5YXV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g008770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549633.1">
        <property type="nucleotide sequence ID" value="XM_014694147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YXV7"/>
    <dbReference type="GeneID" id="26239077"/>
    <dbReference type="KEGG" id="mbrn:26239077"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="287" mass="31501" checksum="1A5AF5AF455E24DC" modified="2021-02-10" version="1">MWSKIVKIFCPAAANAGDNAVGIIVLQILRLCTVITLATMGVAYWVFILNVDKSRTYFVFECASLCCNSIICLILLFSEFPVFKAVKRYFVSSWPVLSDVHGVAWLGSIMLLLGCNIFGNLNTPAMDSEKVAAPFLKLTLAAGVLAFIFGVTNIVCSFVWRNGKEGITSRDVRANGALAKGRRQSPPAYASTYTDQYGKQGAKAGCFTRFTDKATTLFSKKKESARPEISAPVIDVERGHSEKDRFSPVMPGLRRPPTVMHPMHNNTDSGSSSMYSDLYSDPDPNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY59</accession>
    <name>A0A7D5YY59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g090620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541720.2">
        <property type="nucleotide sequence ID" value="XM_014686234.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY59"/>
    <dbReference type="GeneID" id="26245583"/>
    <dbReference type="KEGG" id="mbrn:26245583"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="44546" checksum="86189C5647A29D55" modified="2021-02-10" version="1">MKFLSTVGKARRPKFELHLKIYDLNNIPLVSGSSFIKWHLSHSMHAEHRGRTGKCPISNHKVDYGYSKLIPGVRISMEKNNSLTECPMEFEIVQEFAVAEKITLGYVKLNLAEYVEESESFSREAGSPPRKRSSIGVSPTPADGGARPENRIVEEGIVRRYLMSDSKINSTLKIGILMVQVDGERNFVAPALKTAPVFGGIAGLVAPEAEDDTSPMPSISKPRDAAEVHDLYRRTLAASWSRQPNELPADECIEDIFSGGNGWGTKKEAHDNHNSDEGEAEPLAGTLRPSDFRRYANHHNSHDGSHGRHSRDKSASSDRSVSTVTGGSGGNGTGGHRRGGRFVNEDGRDARDDDLGSSRSGSMGSLAPTLGSSSDGGRGEPAMRRAREVDEFEVREDLVAWKLPGSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ11</accession>
    <name>A0A7D5YZ11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g099830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546366.1">
        <property type="nucleotide sequence ID" value="XM_014690880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ11"/>
    <dbReference type="GeneID" id="26240789"/>
    <dbReference type="KEGG" id="mbrn:26240789"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028800733" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="33"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="162" mass="17369" checksum="941AD90148693DAE" modified="2021-02-10" version="1">MILFRLLLLLASSLTLAAAQQSSAVQTYRESKTYTYYGCYNETTEIDGSDHSRALSGGANEVKKGEMTVPMCLDFCNSGENGAHYRYAGLEWARECWCAQSIAGISAKLDDGECNFPCEGNTSLACGGSLKLSVYRMSSAGAQASPVLLASFLSLVAAFAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZF2</accession>
    <name>A0A7D5YZF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g041500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547495.1">
        <property type="nucleotide sequence ID" value="XM_014692009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZF2"/>
    <dbReference type="GeneID" id="26240058"/>
    <dbReference type="KEGG" id="mbrn:26240058"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="542"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="992" mass="108491" checksum="31E2D1E9826126A6" modified="2021-02-10" version="1">MTASRQQRRQRSGPWLATNNTGIFYRPEAHIDRRSPSTDCFPTPLISPRRSRPHAIHVVTYPSGYVPRELRPDAKTNRERSQRSRGERPPRSSPDSEVPLAFSGATYPGIGQSSSINSSRRSSKIFHHKRNGSSTSSSQIFRPALGKLIASISGRSPNNTEASQPRQPLPTQATPAPGRAQVQTHSAVPATTLSASAGVLASPAYDDARQDSAAQIPHQPHHHLSPPGLSPHRPSHPHPSDEMAVASSNPPAAYNIASHRNSLMSVRSAKSAVTSLVTEVPKPVASGSGVSCSILLAERNIFLTGFDHDGHVHRDGQTGTALLRGKLQLNVTKNVKIKAIQLKLLGRARTEWPEGIPPLKQDVCEEESLRTQVLTFFNAMHDGWEGEYGNQCTYKLKSSSANSSSTNLAVPQAPHRPVSLLLSSSSRNGLTAKELKRLSLQNTQSRSFGKSENGVATTTQVKGFKVFYPGTYNYTFELPIDHHQLETTKLQYGSVKWELHASVDRAGAFKPNLHGTKEVSIVRLPDQMSLETTEPISISRQWEDQLHYDIVISGKSFPIGSKIPIAFKLTPLAKVQLHKLKVYVTESIEYWTNDKRVTRKDPGRKILLLEKTAGKPLDANWATSDLTTVRGGELQPEQRRQARDIANLRRARDAQRRGRAAEPLPEPTNNLLGDLDLGLEHMWGSTEIEANVQLPTCQMMAKNKDLRLNPDCSWKNVNVYHWIKIVLRISRIDPEDPSGKKRRHFEISIDSPFTVLNCRATQANTNLPAYAGPNNNQTPHQSVCGCPDSASLPCEGSQNSSTGTLPGTELSNDGFPLPPQAAHLAHSAMSPMSSISSPLRSVDDLGTQGEPRPIHLLRVPSFNPPAFDDDTAPPPLLVNEVQGAANAPVMTPPPQYDAVVGTPSVDGLADYFTRLANAGYGNEDDNDSGSDDSDELPTRILDRTGRVNVAHPRTPGSRMPSRSFEISRPPVNLHLGDLPTRPGINNEANAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZJ0</accession>
    <name>A0A7D5YZJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mug40</name>
        <name evidence="5" type="ORF">G6M90_00g057690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544351.1">
        <property type="nucleotide sequence ID" value="XM_014688865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZJ0"/>
    <dbReference type="GeneID" id="26242763"/>
    <dbReference type="KEGG" id="mbrn:26242763"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="4">
        <location>
            <begin position="116"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="621" mass="70702" checksum="BC043A99712D0793" modified="2021-02-10" version="1">MAASNSPQLCADAAAYPVESDGTSKTLKYHLLGPSLTKAGQEKVDQSKVSEIIYNASRGSKFFNREEVRDQVLTKKIEQILARKRQLEQADLTQELRNADRVIHEFELSRDLTQHIVHIDCDAFYAAVEQLERPELKDVPFAVGGGVLTTCNYVARQFGCRSGMAGFVAKKLCPSLILIKPSFPKYTAKAQEIREILADYDPRFESASIDEAYLNITEYCHDQDATPAEVIEQMRREIYQKTDITVSAGIAANTKLAKICSNMNKPNGQYVLPSDRTSIMAFMRDLPTRKVNGIGRVLERELLELGVRTCGDIYDQRKYLNMLFGDKTFEFLIGCYLGLGRTKIQPAEEYERKSIGTESTFRELSDSVKLREKLRWTAEELEKDMERAHCKGRTLCLKIKLHTFEVFTRQVVMPRAICSADELYNFSLPILTKLEQEIPAMKLRLMGLRCTHLVSTKKPDTMAFFGLRRKEMTRTGDQCQPNQNLESQITYDKTEVLESLPAEDYIPSVASGQLCNNQSFESSKLGRHGKEVVPNPNKHGLDRREEWWDCPICFRPQEANEKTFNNHIDLCLSRKTIRDAVQCQIPMKAVAVQPELKRLSLNKKKEKVLPGDPKQKRLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z034</accession>
    <name>A0A7D5Z034_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydroxynaphthalene reductase-like protein Arp2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ver1</name>
        <name evidence="6" type="ORF">G6M90_00g056240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Hydroxynaphthalene reductase-like protein; part of the Pks2 gene cluster that mediates the formation of infectious structures (appressoria), enabling these fungi to kill insects faster. The product of the Pks2 gene cluster is different from the one of Pks1 and has still not been identified.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544217.1">
        <property type="nucleotide sequence ID" value="XM_014688731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z034"/>
    <dbReference type="GeneID" id="26242629"/>
    <dbReference type="KEGG" id="mbrn:26242629"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI68925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="27110" checksum="554344DAF2426332" modified="2021-02-10" version="1">MAVDTLSLEGKVAIVTGSGRENGIGAGIALALARNGASVVVNHLSDSSADRAANVAQMLRQAGGKAIVVQTSVDTLEGAKYIVQKTLEGFQTDHIDILVNNAGVGYASRILNEINQAETDRVYQINVNGPLYMAHAVVPHMPPGGRIINVSSTNAKLGHELLSTYSASKAALDNLTVSWAGELGRSKGITVNSVAPGPVLTDIIPKEQMDAIMQPQIDMTKAADRAGTPADIGDAVLLLVNEKARWITGQNISVSGGVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0C2</accession>
    <name>A0A7D5Z0C2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl13</name>
        <name evidence="6" type="ORF">G6M90_00g040260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547375.1">
        <property type="nucleotide sequence ID" value="XM_014691889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0C2"/>
    <dbReference type="GeneID" id="26239938"/>
    <dbReference type="KEGG" id="mbrn:26239938"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="212" mass="23886" checksum="C892F2125B947B0B" modified="2021-02-10" version="1">MAIKHNQKIVNNHFRKDWQRRVRTHFDQPGKKASRRVARQAKAAALAPRPVDKLRPIVRCPTIKYNRKVRAGRGFTLTELKEAGIARPLARTIGISVDHRRQNLSEESLAVNVARLKAYKERLILLPRKSNAPKKGDTKTDLSKVNTATSISSVLPIAPTDIAVKEIKKSEMPKPIDGGAYAALRMARSNKRYQGAREKRIRDKAEAETAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0K6</accession>
    <name>A0A7D5Z0K6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g003540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542010.1">
        <property type="nucleotide sequence ID" value="XM_014686524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0K6"/>
    <dbReference type="GeneID" id="26245041"/>
    <dbReference type="KEGG" id="mbrn:26245041"/>
    <dbReference type="OrthoDB" id="5339332at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="495" mass="53410" checksum="A18386F4422A9FC5" modified="2021-02-10" version="1">MSSTASSASPPGAQHLHSRPPPLPPSSTGPSTRRTSDTRRDPFPFSMTRPFRPNPTSTSVAPSTAEGRAIPVDDTTAEHRTSALRELNSHYPSRHRYAKSTGAQSSTYSEPVIVRSYYSPAPSRHDSSTRRRPGRGGAGSEVGGPVAGVTRALPFSGRVSSAGKGMLSTMARVYNGKMPTVEAQQDTRLPPVEAFSFKSFMANMPTHAGTADINSDLDRIAEICARSRYSLSNQYEVHYAPHGSGVSFLASAQNQEPQGPTLQAVSSDDERDMRNTTRRRRQAARRNSRAMGTLETIMSSSRSSDEEGSKKRSASDLANEVRGRTARKGSGQSSPTPTTSSRSERDLSNSQDSEQQPRTPARRRSTSLALIDSSRLTSTPEATPRTSATALVSEPALPRASNNQLETRTAAESESQQRTLENKPSPRPDRVEEHMARGSISSVQDGARRNGILSTLAGWLPWASHPSKPKGRAEGSLRHLLNNTEAGGKKTEPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0P7</accession>
    <name>A0A7D5Z0P7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Acaa1b</name>
        <name evidence="13" type="ORF">G6M90_00g040550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547403.2">
        <property type="nucleotide sequence ID" value="XM_014691917.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0P7"/>
    <dbReference type="GeneID" id="26239966"/>
    <dbReference type="KEGG" id="mbrn:26239966"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="18"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="295"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI67803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="421" mass="43487" checksum="A09C642F06AE299E" modified="2021-02-10" version="1">MASPRGVANILAKSPADVVILSSVRTPVTRAYKGGLKDAYPEELLACVLKHVRERSVPGTDLGALIEDVGVGVVLSELGGSKAARAAMNHVGYPSSTALFTVNRACSSSLQAVAAVAGEIRGGMARVAVAAGMESMTRNYASRAIPVDAWPALAASPVRDARDCLMPMGLTSENVAERYAVSRPDQDAFAAESHRRAAAARHAGLFDAEIVPVATRFQELDRQGAKVGAEQRLTVARDDGIRENVSVEALARLKPAFKPGGASTAGNSSQVSDGAAATLLMSRGTATRLGLSDRIIGKFVSAAVVGCAPDEMGIGPALAIPKLLASHGLAVGDVDRWEINEAFASQALYCLRKLGLEDAWAAGRVNPTGGAIALGHPLGATGARMTSTLVHGMRRDGHDLGVVSMCVGTGMGMAGLFAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1U1</accession>
    <name>A0A7D5Z1U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g032990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687742.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244029"/>
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    <dbReference type="OrthoDB" id="4655872at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="2EXR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="428" mass="48993" checksum="2FA0CF513406F5AF" modified="2021-02-10" version="1">MVCPTQIKFYVPEECRIFTEFPRLPPEVRERIWEAYLSTPGVHFLKLQTKDGDWSWAERRMQDAFTMQETEGAEDREEMLTVLENDRVPRESHQACLIPVGPCPRADVSQYQALRRQLAILSWTCVESRNVAKRLANRPETLRLANGSIVSLGRSPDLIYLDYFPPSLYQGSGNLETIPDCPDLAHIKRVAVRFSHTWRPTKKLCTCDSCRKTDGAEHTGVYPAHLYQLLARHFPNLEEFFFIDYFIVHKGRAQSKYDGGTWAKGPTIRTRRFQAGNRCYHEANEEEWIVKNKILQITEWLRSTFVSYAMNSPLCQHKNPDKVRFSVLACEWNITSPAEKSATSAVLETKPKTAGMLLGRSTRRHHSLSKRHQLWLSEAEALSNQLSTKSFERMMGTEDARGSFVFPSLSTASPPNQSSQPHVQASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1X6</accession>
    <name>A0A7D5Z1X6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF2461 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g037830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547143.1">
        <property type="nucleotide sequence ID" value="XM_014691657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1X6"/>
    <dbReference type="GeneID" id="26239706"/>
    <dbReference type="KEGG" id="mbrn:26239706"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43827" checksum="AA976CB5B2E89164" modified="2021-02-10" version="1">MPSRKRSAPDQSTDRRRSGRLSASAQKSSYFEDSDTGSNEDEAPVKKQRRLSEKRKSASKQVEEDQYVQDTAVEHHDDEGEEEGDDDEGDDAPRRVEIIPLEKMRDTGGVEYEDHKIHRNTLLFLKDLKANNKRSWLKSHDDEYRRALKDWQSFVEAATLTIIDVDETIPELPVKDVIFRIYRDVRFSKVKTPYKPHFSAAWSRTGRKGPYACYYIHCEPGSSFIGGGLWHPEAALITKLRRSIDRRPDRWRRTFNEPLLKKVFFPNAKANASPEAVIKAFVQKNQENALKKRPMGYEVTHRDIELLKLRNYTIGVKIDADMLAKDTAQQKIQEIMRGLSGFVSFLNSIIMPDPAIDGDDSSDDEDEDEEEEEGDGDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2C8</accession>
    <name>A0A7D5Z2C8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">mcm3</name>
        <name evidence="16" type="ORF">G6M90_00g007810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985799.1">
        <property type="nucleotide sequence ID" value="XM_066129638.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239172"/>
    <dbReference type="KEGG" id="mbrn:26239172"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17754">
        <property type="entry name" value="MCM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000008">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056575">
        <property type="entry name" value="WH_MCM3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23191">
        <property type="entry name" value="WHD_MCM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="437"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="843"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1283"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1309"/>
            <end position="1321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI64609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1437" mass="157910" checksum="0240AE8DFEBDD0B0" modified="2021-02-10" version="1">MIPSTIYRCRQSDTVRQLSSPSASRAEKQALDRDVIVSVLEASATRRDAKSYLQKYTSKKPLSSDLSRASAKDSEAVTAKGDGLEPVNVAIVKLRLPQELSPDALYGIARTLSQLRVLGLLALVVVDCGIAADRQTFDNEAFRLCEAIDSFGSPGAKLADHVFLRRHTNDNPSVVPKFRCGMRVEDLGLLNRALQRGMIVVVPSLSRQDEISSPIPAEANETTITLAKFLTGLQLDGMNGESIDGVAEYLRPKRIASVERIILLDPVGGTPMALRPDVSHRFINLEQEYGELIGSLKSGERITRIANVQSHIANLSLAKDALSLLPPTSSALITSPHAAANTRSGIPSKLPIRALGHPPFGFDNMVTTRNQKNPLLHNLLTDRPAFSPSLPLQRIQDETRGCLQNAESGSATLVKRGMPVTVYPDPRVHPWQPPNPGLPRLRLTDNCIDLPRLFHLIEDSFNRKLDAQHYLKRVNENLAGIIIAGEYEGCAILTWEHPETLDEQTAYDSGRFVPYLDKFAVLKNRQGSSGVADIVFNSMHFMMDSFMLDDEGVRDRIRQAEDFLDPSDPHARSYRSDIILMLQKNQRRLTVNLDHVRDHNNKLAQSILDQPFDYLLAFNHALKKIVETVPQARPDQTAKDTVYYCAWAGSFGLNSCNPRTLSSHHLNHMVSLEGIVTRCSLIRPKVVRSVHYNEKAGKFHFREYQDQTMTNGVTTSSVYPREDDEGNPLVTEYGFCTYRDHQTVSIQEMPERAPAGQLPRGVDVILDDDLVDRVKPGDRVQIVGIFRTLGNRNANHNSALFKTMILANNVVLLSSKSGGGIATAAITDTDIRNINKVAKKRNLLELLSQSLAPSIYGHDHIKKAILLMLLGGMEKNLENGTHLRGDINILMIGDPSTAKSQLLRFVLNTAPLAIATTGRGSSGVGLTAAVTTDKETGERRLEAGAMVMADRGVVCIDEFDKMSDVDRVAIHEVMEQQTVTIAKAGIHTSLNARCSVVAAANPIFGQYDPHKDPHKNIALPDSLLSRFDLLFVVTDDIEDTRDRQVSEHVLRMHRYRQAGTEEGAPVREQMSQNLGVSAESQVGPQQPTEVYEKFDAMLHAGVTRTSGRGSAKKPEILSIPFMKKYIQYAKTRIKPILTQDASDRITEIYVGLRNDEMEGNQRRTSPLTVRTLETIIRLATAHAKARLSSRVEDQDAAAAEAILRFALFKEVVVDESRKKRRRTQAVEFASSSEDSSDDGDESEGEAANPRGARSTRSATRAIHPTTRSRTEVSRAISGDGHGSVSNNGNAAVVDSLSTQHTTPRRSGRSRGSALDTSQSQTSFASSASASALLSRTQEDSQIEQDLASEAAGLVIDDAAPIDTRRVAVFRTALGQLLNSDLFEDDSAALDAVISAVNRKVSSGDGGAFERAEAVKALKKLEEANHIMFADGELVYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2T2</accession>
    <name>A0A7D5Z2T2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dys-1</name>
        <name evidence="12" type="ORF">G6M90_00g049670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986428.1">
        <property type="nucleotide sequence ID" value="XM_066130471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2T2"/>
    <dbReference type="GeneID" id="26242416"/>
    <dbReference type="KEGG" id="mbrn:26242416"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="352" mass="38886" checksum="5CA135397B4C5ACD" modified="2021-02-10" version="1">MAQDAPPSQATGAVLMKSEAMPDGSQPVEELDFNKLKRPITAEDLFLGMRHMGFQASSMAEAIRIINEMREWKDPDTSEKTTIFLGYTSNLISSGLRGTLRWLAQHKHVSAIVTTAGGIEEDFIKCLGSGTTYMSSFSVPGADLRKRGLNRIGNLIVPNANYCAFEDWVVPILDKMLEEQEASKGTDEEINWTPSKIIHRLGKEINDERSVYYWAWKNDIPVFCPALTDGSLGDMLYFHTFKASPLQLKIDIVEDIRRINTISVRAKRAGMIILGGGIVKHHIANACLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKIGADSVKVYMEATACFPFIVANTFAKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z347</accession>
    <name>A0A7D5Z347_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g073900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545675.1">
        <property type="nucleotide sequence ID" value="XM_014690189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z347"/>
    <dbReference type="GeneID" id="26241708"/>
    <dbReference type="KEGG" id="mbrn:26241708"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="58981" checksum="4CA23D237AEF8287" modified="2021-02-10" version="1">MDETDDSSLLKKHIALIQADTKSLEESEVSGTPIFTESVRQHGNNASTSNGEIFTQYGLLGGDVAKLHASKDMELDIENDPRVFYNIKAPSSVFICGSQGSGKSHTLSCLLENCLIPTDANTLPRPLTGILFHYDPFFSDNRGQRCEAASISSHAGVKVRVLCPPTNVGQIKKLYKSLPNVEVEELRISQRDLNTKRMLDLMAVSSIQGGTMPLYLHIVTRILRELRVQQQKKGGHFNYRAFRKAIAAAELSPGQSGPLEQRLDTLESFMAEEDVAESKIPGFTSYKPKGKQSMFDPNEFTSTATTWEPKAGQLTIVDLSCPCVTAESACSLFNICLNLFLEQPSDDIGRVIALDEAHKYMTESADSQTLTDSLLSAIRLQRHLGARIVIATQEPTISPKLLDLCSVTVVHRFTSPNWLGSLKNHLAGATAGWKTATEGEGESGKSSAESMAELLSRIVSLRQGEALLFCPSGIVGVKTPKRTDDIDGIADGFAKWCLEQDRSGAYSDCGNGLDYLGQRIMKIRVRERITEDGGKSVMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3A4</accession>
    <name>A0A7D5Z3A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g015390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548988.1">
        <property type="nucleotide sequence ID" value="XM_014693502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3A4"/>
    <dbReference type="GeneID" id="26238432"/>
    <dbReference type="KEGG" id="mbrn:26238432"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI65329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="427" mass="44761" checksum="383872A4FAC9A5ED" modified="2021-02-10" version="1">MRRVVVTGLGAVTPLGVGIRQIWNRLLAGESGIVSVASRQPQARWKELTSTIAGVVPVGSEPGQWRASDWLSASEQRRMSTFTQYAIAASDMALKDAGWDVTTPEDMEATGVCLGSGIGNLDEIYETSLAHHTDGYKKVSPLFVPKILINLAAGHIAMKYGFQGPNHAATTACTTGAHSIGDASRFIAVGDADVMLAGGSEACIHPLTFAGFGRARSLSTAYNDNPSGSCRPFDAGRNGFVVAEGAAVCVLEELEHAKARGARIYAEVKGYGCSGDAYHMTAPREDGRGAFLAMKRALKNAGVKPLQVDYINAHATGTQVGDVAEAAAIRRLMLGQEGVSAESQVTVSSTKGAMGHLLGAAGAIEALFAILSIYEGVVPATQNLHKPDVGINFNFVPLTAQEKTVRVAISNSFGFGGTNSSLVFSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3U1</accession>
    <name>A0A7D5Z3U1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase ccsG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ccsG</name>
        <name evidence="11" type="ORF">G6M90_00g093130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541956.1">
        <property type="nucleotide sequence ID" value="XM_014686470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3U1"/>
    <dbReference type="GeneID" id="26245424"/>
    <dbReference type="KEGG" id="mbrn:26245424"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF4">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI71905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="484" mass="55341" checksum="4E17FCA413FB2593" modified="2021-02-10" version="1">MLNAAIIPFAILAVSCGVFYSLVCLGGSAPRKRALAHIPELRFEKDNTPDRYRNDTRSLLRIGYEKYLQYGVPFQMYNPIGELGNQVILPMKYLDEVKRAPKSLFSFEVFSEKLFLLNYINAPRQTNAATHAIKFHLNRNLNNVMNGLWTEAEASLKKTIPSPGRQSIPGGDLACNILSPVMSYILVGPSLCRDPEWLDIAVETTFSVFDASLDIRKKYTANWRWLARWQNGTAQRLGTIRKKALELIKPLYDERRQAINENDGRSDSGSEMFHDTIYWLLGQKRADTSLEAYHAEITAEINEALAEFKTSGSEWTLQRVARMRKLDSFMKESIRMNPMAFITGQRYAVKSHTFKDGFNLPAGTMFHFAADAVHHDPNKYPDPDKFDAYRFLRLREKVDPNQFHFAFVSDMNLNFGAGQHTCPGRFLAAVVLKFALILLITRYEIKFSDGSTQKPPNVFVDNTIRCKTTYKASYLRSNFCAWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3Z7</accession>
    <name>A0A7D5Z3Z7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g069410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987097.1">
        <property type="nucleotide sequence ID" value="XM_066130910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3Z7"/>
    <dbReference type="GeneID" id="90967917"/>
    <dbReference type="KEGG" id="mbrn:90967917"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="212" mass="24537" checksum="0F6257639D756EB7" modified="2021-02-10" version="1">MFEIGPENESLQHNDDPGRQYHLSHMEQQKEMLKGHRDEIIIAVALASMPNIRRVTLPNHWCPARDLLGTSYFSPWRPKLPRGEPSGLPLQSGRQEHCRTNIDYGFKVLYRAMKLARPSIQELSVDYYDDLCRSERLLTRGIFPRSLLFSPRDLEDCCTAFSQLRKIPFSLCPASTDDEWDILMEGNLAAVDRYTSKQENNQHILEETDCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z456</accession>
    <name>A0A7D5Z456_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g082800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543502.1">
        <property type="nucleotide sequence ID" value="XM_014688016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z456"/>
    <dbReference type="GeneID" id="26243679"/>
    <dbReference type="KEGG" id="mbrn:26243679"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="304"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="591"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1269" mass="141687" checksum="58F946D48FC5F246" modified="2021-02-10" version="1">MAGIDALLREQEDGTSLSGNAQGLDSEALKRHLEDKFLTPSREFSSEWLNLLQQRWDFETEYTSLFKLAPTQTRTVTRFQRHGLEGRVTGYKNVTLPSNSATAKNSTSLLRKPANRADFVRGAAGFFPFAPGGLEGIEATAALEDQVHAGGIEEGAKANKLDRVIQLGEGGLLQIAPGLDRGIDFSKKKNAPDEEAASAVQEALEEEPENAGSVDETEGDSPDETPADASDAGEDEDDIDDILPIEFPALEPHGVLAASSARKAGREWAHMVDIRQGMPNFRELVPDMAREWPFELDTFQKEAVYHLENGDSVFVAAHTSAGKTVVAEYAIALAAKHMTKAIYTSPIKALSNQKFRDFRQTFDEVGILTGDVQINPEASCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDFERGVVWEEVIIMLPEHVTLILLSATVPNTYEFASWVGRTKQKDIYVISTSKRPVPLEHYLWAGKDVHKIVDSDKKFIEKGWKDAHGAVQGKETQRPSETTVAMRGGNSRGGQRGGQQRGGPQQRGGRGGGQQRGGNQQRGRGGPPRASHAPGHMGRGGRAGGMTSAAQDKNLWVHLVQFLRKKSLLPACIFVFSKKRCEQNADALSNQDFCTAQEKSHIHMVIEKSIARLKPEDRQLPQIIRLRELLSRGIAVHHGGLLPIVKELVEILFAQTLVKVLFATETFAMGLNLPTRTVVFSGYRKHDGHSFRNLLPGEYTQMAGRAGRRGLDTVGSVIIVPPGSADDVPPAAELRNMILGEPSKLRSQFRLTYNMILNLLRVEALKIEEMIKRSFSEHATQALLPEHEKDVKLAQADLAKVKRESCKICDTAMDECHQAAQDFKQLTLELYKGLLRITFGRRMFSQQRLIVFNWEGVRTVGILLSEGMSPKGTLDDPILHVCAIKPLRERRDATDQLPFIPAFRRYLHKLPQGKRRLQIKTLHVPLSDVECLTKWVLKGTIPEIFKGGEAGQQAMEKLQDICSGWDARWDEVDMGKIKSMQLQEIVEKRVQLVKAISISPVIKCQAFLKHFAMCHDEWLIKEHISQLKQSLSDQNLQLLPDYEQRVQVLKELDFIDDATRIQLKGKVACEVHSGDELVLTELILDNVLADFEPAEIAALLSSFVFQEKTTVEPTLTGNLERGRDTIIAISEKVNDVQTRLQVIQSADDSNDFVSRPRFGLMEVVYEWARGMSFKNITGLTDILEGTIVRTITRLDETCREVKNAARIVGDPELYQKMQEAQELIKRDITAVASLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4A4</accession>
    <name>A0A7D5Z4A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g049030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545014.1">
        <property type="nucleotide sequence ID" value="XM_014689528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4A4"/>
    <dbReference type="GeneID" id="26242355"/>
    <dbReference type="KEGG" id="mbrn:26242355"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="559"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="599" mass="64063" checksum="187243A16CA19D8A" modified="2021-02-10" version="1">MRSTKTGPLLTQDEARVSSGYQTLDPETQSVGSDGDETQSSSTLTLPCGSGPDQLDDQTQRLPFPRLMAAYLCLCLCYFISYLDMNAVTTSLPTISDALHAGPGITWVGTAYLLGQTSCQPLYGRISDIIGRKPILLFSVGCIIVGDILCGFAQTPIWLYTSRAVVGIGGGGISSLVAIIVSDLVSLRSRGKYQGIISLAIGTGAASGPFVAGGLIQTGAGGWRWVFWVPSIAAACCFGLLVFLLPLKPVSGNWKDKVGKIDWLGVVVSVAGIVLIMIPLNSGGSMWPWDSAETISTLTVGVVLVVGFIAIEAFVAKMPIIPLRLFRHRSSSLLLVMGILHDFVWQATQYFIPLHLQTVRGYTALQSATIILPFLLAQGLAGAASGPVMSKLARYSPVLRTGFLLWTLGCGLQLLFNLHTSTGTYVVVLAIEGAGVGWVHQPGLVALQANCRDEDRAVATGTRNVLRSLGSVFGVAVSTSAYYAVLDKALRRSVPDSLRVRVLNGTWRIGETGTERFESDILNARMQGFRVVFIVLVPLMAVCLLASFFVADVVLTGDAEKQEPKETDEESPSDDSTMMPRPGVSGILQAVRGQEQRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z791</accession>
    <name>A0A7D5Z791_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">hmp_1</name>
        <name evidence="18" type="ORF">G6M90_00g050900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545190.1">
        <property type="nucleotide sequence ID" value="XM_014689704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z791"/>
    <dbReference type="GeneID" id="26242531"/>
    <dbReference type="KEGG" id="mbrn:26242531"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="16">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="149"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="418" mass="46899" checksum="1C4A2A8A020129BA" modified="2021-02-10" version="1">MALTYSQCQKIRATVPALNARGEEIIASFYQSLLRGHPELRSYFNTANQLNKLQPKAMASLIIQFANNVSHIYELIPKMERICQKHCSVGVQPHHYKIMGAYLLEAFTGILDPSMTPDAKMAWNNAYWMLANMFIAREKQLYKTFGPWTDWRPFDIADRVHDGENVVSFYLKPRDKKPLPPFMPGQYVSIRVAVPGKEHKQIRQYALSEAPNPDYYRITVQRNRGAAAAADDDEQHQSACPYASPPGAVSNHLIDSAVAGDTLELSHPAGHIFLDTKNLSNAPLVLFSTGIGATPMLSILNFTAKEQPARPVSWINASQGAMPFQARVDSLAARRRNLRNTTLGIAHDGHASADCDGQDDARLDLVSLRPDDLFLRNECTEYFVCGAENITVQFVEFLERHGIDRARIHCELQTVARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z851</accession>
    <name>A0A7D5Z851_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bioF_1</name>
        <name evidence="6" type="ORF">G6M90_00g082440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543473.1">
        <property type="nucleotide sequence ID" value="XM_014687987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z851"/>
    <dbReference type="GeneID" id="26243650"/>
    <dbReference type="KEGG" id="mbrn:26243650"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF77">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="5">
        <location>
            <begin position="54"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="52268" checksum="D0F2F19DA7BE3F70" modified="2021-02-10" version="1">MYYESMVETWLKDHKLKTPEMQNEPAFYRNLEQRLDTLRAEHKLLTAKPRWDTPMVDFASNDILSLSRTGRIREAFLQEISRHENWNLSAGGSRLQNGNYNYILEVEREMAEFFGSETAFFGNSGFLCNAGITGCVALPGDCYVFDELVHASAHEGMKLGRASHKVSFRHNDVNSLRETLTNLRETHAEFKLGTQSILILIESIYSMNGDVCPLEEFVHVAKQVFPLGNAQFIIDEAHSVGVLGPHGRGLVSMLGLEKEIAIRVHVCSKAMASTGGVILCNKTVRSLMMNQMRFAVYSGAPSFPMVASARAGLQLFRSGGTHEEQERIQKTISYFFKRLTSKPDWQQAVAAGLLSCPVAEGWEQRQFHAHIIPIRTRPRHEQYLFFHNMLANIMAYNFAYPVVPKGESRIRIVVHAHNTEDDVDKLVASICQWAHEMLDLEKCGSNNTLPSAASKVFASQAAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8L2</accession>
    <name>A0A7D5Z8L2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g055940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544187.1">
        <property type="nucleotide sequence ID" value="XM_014688701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8L2"/>
    <dbReference type="GeneID" id="26242599"/>
    <dbReference type="KEGG" id="mbrn:26242599"/>
    <dbReference type="OrthoDB" id="2394218at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="580" mass="64761" checksum="DBD70A4BD102E051" modified="2021-02-10" version="1">MSHRADVASGRLHLYVGVDFGTTFTGVSWMAPALDERRITLVSDWPGGSADKVPTILAKEATENDRMWGFLCNHLDESSKWRFLKLSLDREPGQLKGTPWAPNSTPEAYALVEDYLGQVYRHIRRSIPSEIPNAAPGLQGWDSWEIDFVFSVPGTWSPLVVHRFLETARRAGFGGQAHHKVVPGLTESVAAVVATSEMNIDLDEGRTVLSIDAGGGTTDFAFVTFQSMKPIIMKQVLPATAIGVGSVMIDLTFKNLVEARLEDYTKSPDLSRACAAEMSQGNEFQRWKCAYAAGQNTMGHMFRATPISNAFGNLPIPVANELASFKREELDQMFDRQIQDIQSHFVSAVDEFERVGGTRVRHVVLSGGLGASDYVLEKLQEFLEWLRNTRPCLGEAELVRYSYPPIAVVRGLLIDRKNGILGPRIARASYGVVSEQVDSNHRQRGDDSQGQITWVIKQGDTIQRHHRVTHRIARTFRKGDAEDWTVGIVCSSRSPRYLPNKMQQSGVQELHQVSIPLNGPPAEVKSRFPLLPRYQRYECELQLVVGDSGQCLVRVVSSRGVSLETTQARHLMARHTRPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8X0</accession>
    <name>A0A7D5Z8X0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ppi1</name>
        <name evidence="9" type="ORF">G6M90_00g071570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545902.1">
        <property type="nucleotide sequence ID" value="XM_014690416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8X0"/>
    <dbReference type="GeneID" id="26241935"/>
    <dbReference type="KEGG" id="mbrn:26241935"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI70728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="164" mass="17628" checksum="2758F703C064F971" modified="2021-02-10" version="1">MTQPQVFFDVSADGAPLGKIVFKLYNDVVPKTAENFRALATGEKGFGYAGSSFHRVIPDFMLQGGDFTNHNGTGGKSIYGEKFADENFSLKHTKPGLLSMANAGPNTNGSQFFITTVVTSWLDGKHVVFGEVVEGMDIVKKIETMGSGSGKTKKKIVIDKSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z957</accession>
    <name>A0A7D5Z957_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RNTR</name>
        <name evidence="12" type="ORF">G6M90_00g092970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541941.2">
        <property type="nucleotide sequence ID" value="XM_014686455.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z957"/>
    <dbReference type="GeneID" id="26245409"/>
    <dbReference type="KEGG" id="mbrn:26245409"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
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    </dbReference>
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    </dbReference>
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        </location>
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        </location>
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        </location>
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        </location>
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        <source>
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            <dbReference type="EMBL" id="QLI72707.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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            <begin position="19"/>
            <end position="53"/>
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    </feature>
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            <dbReference type="EMBL" id="QLI72366.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="53" mass="5397" checksum="60F9ECBD73DE7F30" modified="2021-02-10" version="1">MKTSLALVLGAAASIVTAGIVITPIKDDQIVPRMGDDCAFGVVTPQGCGPKRN</sequence>
</entry>
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
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        </source>
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        </source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="8928" checksum="1336886592181B61" modified="2021-02-10" version="1">MKTTLVLGLFTSSILAATVGEGVKPATKDSSALSSVPQNPINIAASGSPDAWCGGFTAYQCSVLCGNYGYSCYYCSSSYCNCLNSGC</sequence>
</entry>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <begin position="25"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="162" mass="14615" checksum="EEB626141274CC69" modified="2021-02-10" version="1">MRFNVNSTLLAATLALSAAQTGLAAPTPQDLSSIPVIGPLLSGATGAAAGSGASNPLSAIPVVGPLLSGASGSANTTAATTANPLAGLLSSIPGLGSLLGGAGGATASSGASNPLSAIPVVGSLLSGATGAATGSGAGNPLGSLLSLGTGLLGRSTDSSTAA</sequence>
</entry>
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    <accession>A0A7D5ZAT6</accession>
    <name>A0A7D5ZAT6_9HYPO</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="387" mass="45301" checksum="962E58E0246E5DC7" modified="2021-02-10" version="1">MVLKLLKVSNTKAGRFPCLRYKITDIRLFKPGQVPGYEWTRRWNNNISDPIQKWASSDVKSIRISAGYSTKCIDLKVRKFVPQEGDKLERTWDFEGRKRSVKIPPYALMDLDDGKSAYMSHIRDTMGDTLQHVAERSCGLLKKTYIQAFQMYQDPSIPEDWKQLFDWTFRLWVAVRLSTTSEFIVGEEKLGMPDNILDSTSPHSGKIPVPPVLGAQLDLVLIHHIQTKLRRELLDKLQKMILKNKPSTWFVTYLVTFMLLHNAALITAHDAAYARKHGIKRRFAREDKVKEYHLGRFVELLGANILLAHFHYCNKGWYPFSEDCKGQDLRALADLNDDKIRFVHATRKFAREHKREWDILREQGAWEDDYFFVSQLFEENWHPRSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBG5</accession>
    <name>A0A7D5ZBG5_9HYPO</name>
    <protein>
        <submittedName>
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    <gene>
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        <name evidence="6" type="ORF">G6M90_00g081950</name>
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        <lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
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        <property type="nucleotide sequence ID" value="XM_014687942.1"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="268"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="642"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="994"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1019" mass="114971" checksum="DCEABE3680111D4B" modified="2021-02-10" version="1">MESSVSDFFSRTNAAIQPPRDWRQMPEVPDAEEFMSNEPPRLPLNDFEARPQLRDQFLETQYRLYRYEATETLRRAIQTLRRARRHQSSPNEQEGSAANKLERVNVYPEVRVAGFALGASTAGQRLIIPNAPVRDEDDDDDVSPDELELFCPGTLLVLSSDCFETTCYVATVLENEGLRDVPPSIDICWGKQDYVVLDPMLNLAMLEPTNAYFESLRHTMVRLQDMSRTSCLLDQYLFSPRPHSVPNAPYLKETPNGNPAVPKTARSLDKSQHDAFTEATTREVSIIQGPPGTGKTFTSNVILQSLVETQRQCREARINPGPKIPVIVSAQTNHALDQLLQIYVETPGAGKVVRLGGRSINEAIAKLTIPKLRRTHVPVSYRAQPAGKLWSFAGRAMAAFRKAVIPSDDIENAKELFDYNLISEDQYYSITNDDWESNEDGKGDLADWLGKPQPKLEDSGTSRDDKAKQQARWQGSRVFFVPLPTSSDRSASSVSQDRAIHLLDTTRNLYNIRPEDRQVVYNYLRERLHAKKHPSMADLIQSYNGARASIQSTKVANDLAYIQADEIDVVGCTVTGLMKYRQLISSLRPQILLMEEAAEVREGDTIAGLLPSIEHLILLGDHQQLQPHVDMVELASDPYRLNISMFERLIKLGIPHKTLLQQRRMIPCLREIVQLFYPKLVDHTPTISKLPLQVSGVSKPLWWFQHDWPEEPGICNGTSLQNFREAQMIVLFVQYLVTLGNIPPERITMLTYYRGQVDLLNKQLAASQKLASLEIEWSVRTVDGFQGEENDIILLSLVRGPNGKAGFLSQENRAIVGLSRARVGMYIFGHQEVLLRHPRRTWSKVIRQIGENQGRSLPLCPDPDTDNVVQVDHPDQFKPILRNARHKMPRKERQKGSYSSGSEKGGRPESSGARNVESPPKIQAPESRAAESSQSQDAPSPQVRLTFWTPNLPSLPPERPVDTTESLASDIELLSFEDSETVPISQQLAWDVTPLQPATEEAEEEWLMEFSDDEAREDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQG6</accession>
    <name>A0A7D5UQG6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRP10</name>
        <name evidence="3" type="ORF">G6M90_00g009970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549519.1">
        <property type="nucleotide sequence ID" value="XM_014694033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQG6"/>
    <dbReference type="GeneID" id="26238963"/>
    <dbReference type="KEGG" id="mbrn:26238963"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="92" mass="10024" checksum="E3CF9DCC963008A1" modified="2021-02-10" version="1">MSGGHKPIRLPPLKTLRVHNPKRQPENPCIAIMSSVLACWASAGYNASGCAAIENQLRKCMDGPAPPPAPANTVNYHLSRMQKHVTSPRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQI2</accession>
    <name>A0A7D5UQI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PBP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g003280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985767.1">
        <property type="nucleotide sequence ID" value="XM_066129547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQI2"/>
    <dbReference type="GeneID" id="26245017"/>
    <dbReference type="KEGG" id="mbrn:26245017"/>
    <dbReference type="OrthoDB" id="10260248at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052738">
        <property type="entry name" value="ABC-Tungstate_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37945:SF1">
        <property type="entry name" value="EXTRACELLULAR TUNGSTATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP" evidence="1">
        <location>
            <begin position="56"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="323" mass="34346" checksum="C14E17A5085A2BCC" modified="2021-02-10" version="1">MAADAVGSEFVSKDAEANTMVSAKNLLGGGFAASCAAITPAAVYDGGFSNAASKVELRIGNGGAGQSGLIKALSDAFIRDAVASGSPPFKVAWYTSDTTYSIKYLSTGDIDVGITYTPSAEDIAIRQGIALSPSYYVFRDHFLLVGPRSNPANLVASDDIHTMFSKIFDVAENNKTDPPVRFLSRYDKSATNIKESLLWASIGQVPWATAYSTWYHQYIAFPMQALTAAILLQEYTITDRGTILSLDARLRNQTVVYKAGTDGADDPLLNPAHLLIGTRAANPNMAQAFARWLVSSKGQGVVGNFKKGGQTLYSVAPSSNSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQX5</accession>
    <name>A0A7D5UQX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g025300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548053.1">
        <property type="nucleotide sequence ID" value="XM_014692567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQX5"/>
    <dbReference type="GeneID" id="26237497"/>
    <dbReference type="KEGG" id="mbrn:26237497"/>
    <dbReference type="OrthoDB" id="5343688at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="256" mass="27957" checksum="1BC513485132964D" modified="2021-02-10" version="1">MAVQTPAKPSIAANGASNHDGLPSLTFSVVTKEVEKQDAMRLVADSIAQQRQTASFSVIVHPACFVGLVAACTAIYRQNAHRDFGTALVMVCGLVIAYLAGVRLLTANYIRIAESLKWKEWITSPEGKEDYVLAARYGDELIATTVLRLVAPAGSTKKTRLSSVKGGSGVIRAWTTKYRYRNKGIGGDMLRLAVLTTRSKCGDNAQVTFDPDHANSARPLHDMFNRPFIKREERAKKALAHALEACDRGESSFQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR38</accession>
    <name>A0A7D5UR38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosome maturation protein SDO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sbds</name>
        <name evidence="13" type="ORF">G6M90_00g012960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549226.1">
        <property type="nucleotide sequence ID" value="XM_014693740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR38"/>
    <dbReference type="GeneID" id="26238670"/>
    <dbReference type="KEGG" id="mbrn:26238670"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046928">
        <property type="entry name" value="SDO1/SBDS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20268">
        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="11">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS C-terminal" evidence="12">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="313" mass="34227" checksum="304932824BDB9E4F" modified="2021-02-10" version="1">MSRQINQPSNQIKLTNVSLVRLKKGKKRFEIACYKNKVMEWRSGIETDLDNVLQIPNVFLNVSKGQTAPKEDLEKAFGKGKSTDDIVLEILKKGELQVGEKERAAQLERVHNEVIGIVASKLVDPRTKRVYTSGMIEKALDMLSSQAHNADKDKSATASGAATPTTTPATGDDGEAKPRTKEHIWTGVVTTKSAKSQALEAMKALIAYQPIPVARARMRLRISCPTSVLKQAVKAAKAAAKEEDGEQKAPGTVKDKILGYVEQVENQDVMGSEWEVVGFVEPGAFKALSDFIGNETRGQGRVEVLDMAVTHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URK8</accession>
    <name>A0A7D5URK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g025820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548001.1">
        <property type="nucleotide sequence ID" value="XM_014692515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URK8"/>
    <dbReference type="GeneID" id="26237445"/>
    <dbReference type="KEGG" id="mbrn:26237445"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="78"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="583" mass="64984" checksum="DCC06B90C5367F7C" modified="2021-02-10" version="1">MRICVFQSSYEGSDSVLGDLHDSSQPGLFTSQHEFTYRFIHKDNAQQEIDAAVAEGFDFYFNFLWGTLDDPVAGTLASRYFESLGLPSCGVRSWERSKTKNDFYKAARLHGTPPVPGADRFPLFVKPANGCASQLIDEHSVCHNQEELDLALGRINKSLHEARVRRAHALGIKDPVEYASSYDPTSRDNDDVVVQQYIDGKDYTCSVVEMGQSCIALTPFVYNTKQTTSKDKFLTFDLKFDQETRIELLQKQHNPTLFERLQQVALEAFTISGCKGSNMGCDVDLRATTTGEVFAIEVNPQPAAFMPDGVFQDLPIIHSLPGGHSAVINIFIANHMLGHPDKWSHQPKIASVYDGFAPKYDTLVNQAATMLESARRLAGRFEFSGTVLDLACGTGIFGRALAESKKSSSPAVAVSSQEYRLLGCDISPGMLDICRSSGVYDNLFTDSMESTLLRISNEDHGKSVDHITCFSSMHFLRPEMFSFVMVLCFTLANKSVTISVDEIPDVYNEKLKKSGHDFMHSTNHLASMGSFCEPKGWRLECRETQYSWTSPATGDRIYTTYFRFERVDGDTRDVMIGGVQLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UST1</accession>
    <name>A0A7D5UST1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g029080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541259.1">
        <property type="nucleotide sequence ID" value="XM_014685773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UST1"/>
    <dbReference type="GeneID" id="26245894"/>
    <dbReference type="KEGG" id="mbrn:26245894"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="187" mass="20173" checksum="722C3031C6AD1EA3" modified="2021-02-10" version="1">MKATQSSVMDLPASTDVIAPTSTTTPSRSSSVFHGHDAFPSDPYPRLSISTPARILLGTVSSGVIGFTLGAMQGGQMAQLRFRAEHAHKMPDTTTGWYLYHKSKNYHAMQGGIREGFRMGAKTSFWSFVALGLESTVDRYRGSSDMFSTTMATLTVAGAFSLCRKWNLDGIAHSLSITSSHRASSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT41</accession>
    <name>A0A7D5UT41_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose/lactose metabolism regulatory protein GAL80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GAL80_0</name>
        <name evidence="3" type="ORF">G6M90_00g025890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547993.1">
        <property type="nucleotide sequence ID" value="XM_014692507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT41"/>
    <dbReference type="GeneID" id="26237437"/>
    <dbReference type="KEGG" id="mbrn:26237437"/>
    <dbReference type="OrthoDB" id="4939225at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="143"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="388" mass="41829" checksum="8CFAC14BA738B408" modified="2021-02-10" version="1">MAPIRTAIIGLSSTAATSWASTAHLPSLVTPAGQSRFQIVALLNSSVSAAEFAIKTYDLPPGTRAYGSPEDLAADPAVDLVICSTRVDRHYETVLPSVRAGKDVYVEWPVAATDADIRSLADEARRSGSTALVGLQGRWAAPVLKLRELLDAGAIGKVLSVDVRAYGGTKDRETLPVGLKYFADRGVGGNPITIGFGHVFDFVQSVVGDVVPETTGSRLQLQRRRVRVRDPENGEVVETVRSNVPDLLYLHGRLAESPRNDADATLAFTFRRGQPFPGTPSLAWSIYGVDGEIRLVAPAGISLQADACDESVTIQVHDFDTDTVRDVEWDWTDVEKQVPVRGRSVQRVLYAYADWKQGKSDGAGAWVGVDDAAARTSQIQKLLDGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTC6</accession>
    <name>A0A7D5UTC6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein hob3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hob3</name>
        <name evidence="5" type="ORF">G6M90_00g048230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544938.2">
        <property type="nucleotide sequence ID" value="XM_014689452.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTC6"/>
    <dbReference type="GeneID" id="26242279"/>
    <dbReference type="KEGG" id="mbrn:26242279"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="261" mass="30096" checksum="3706CB489D8E3F55" modified="2021-02-10" version="1">MSWAGFKKNVNRATTQVMMKTGHVEKTNDRDYELEERRFKTMEAASLRLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDSGARDGVSRSYKQAVEDLDSETIKALDGPYRTTVLDPINRFCSYFPDVNECIKKRSHKLLDYDALRAKVKRLVEKPDKDATKLPRTEKELEMAKLAYEQLNEQLFSELPQLIDLRVPYLDPTFEALVKIQLRFCAEAYSRMAQVQQYLDADTRDLYAEGHLDARVEQVLQEIRELSISGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTK5</accession>
    <name>A0A7D5UTK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRPL23</name>
        <name evidence="8" type="ORF">G6M90_00g041940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986216.1">
        <property type="nucleotide sequence ID" value="XM_066130291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTK5"/>
    <dbReference type="GeneID" id="26240097"/>
    <dbReference type="KEGG" id="mbrn:26240097"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="179" mass="20201" checksum="9E2D9DF78E51B655" modified="2021-02-10" version="1">MSQTLGLTRLAYSRVWHQISASKPHQTLTTQPDVTPPSLGRLASRIAVLLMGKHKPIWDPSTDCGDYVVVTNCAALHTTGRKMWRKSYYRHTTRPGSLKELTMDALMEKHGGGEVLRKAVRGMLPKNRLRDKRLARLKAFEGDAHPYKDNLVRFGGVVVGSEGWQQAVEKIRESDKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTM0</accession>
    <name>A0A7D5UTM0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Golgi apparatus membrane protein tvp15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tvp15</name>
        <name evidence="6" type="ORF">G6M90_00g023290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548226.1">
        <property type="nucleotide sequence ID" value="XM_014692740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTM0"/>
    <dbReference type="GeneID" id="26237670"/>
    <dbReference type="KEGG" id="mbrn:26237670"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI66271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="130" mass="13844" checksum="6FD19CB5B45BFE64" modified="2021-02-10" version="1">MELSDIFRIVNLAVAVITILGGIASIFGFQLQSIILGAYMIVFGLAIALLEFQIPPQVSRYANFLFSFIGRGIFYILLGGLLLGGHVLSNIAGSIVGIVGVGYIALEFIPSIEPPSNMREADAGWGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTN8</accession>
    <name>A0A7D5UTN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acmsd_0</name>
        <name evidence="5" type="ORF">G6M90_00g014520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549070.1">
        <property type="nucleotide sequence ID" value="XM_014693584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTN8"/>
    <dbReference type="GeneID" id="26238514"/>
    <dbReference type="KEGG" id="mbrn:26238514"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="105"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="377" mass="41201" checksum="9B33D268753B83F2" modified="2021-02-10" version="1">MATSNPTVVDIHTHMYPPQYIKILESRTTIPLVRKFPQAPEPRLILLEAELGDLEKAINDPSAKPPGRPLTSHFASLDQKIHFMDTHRIDISVISLANPWLDFVHASHAGDIAESVNVEFSDMCGKHHGRLFFFGTLPLTAPLETLLASISHLAALKYCRGVILGTSGLGKGLDDPHLIPIFEALAAANLTIFLHPHYGLPNDVWGPRAGEYGHVLPLALGFPMETTIAVARMYLAGVFDQVRDLRMVLAHSGGTLPFLAGRIESCIFHDGQLVREGKVGENRRTVWDVLKEQVYLDAVIYSEVGLKAAIDASGSDRLMFGTDHPFFPPITTDEQGQWESVSLNARAVAEAVGEGSAEAKAIMGSNAIRVLRLEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTY9</accession>
    <name>A0A7D5UTY9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dbl4</name>
        <name evidence="13" type="ORF">G6M90_00g043950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547730.1">
        <property type="nucleotide sequence ID" value="XM_014692244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTY9"/>
    <dbReference type="GeneID" id="26240293"/>
    <dbReference type="KEGG" id="mbrn:26240293"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="137"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI66756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="527" mass="60455" checksum="DBFAE774DF4FE14B" modified="2021-02-10" version="1">MDSEDEYVSGMSTDAEGMQEYSGDEMSAADDFEDDFDEPDPDFGITSKDITKTKQPAHVVSFKVLKPSDIQHQQDDMINEVNMILDMRKEDAAIMLRYFRWNKERLLEDYMDRPEKVLEAAGLSSNTAALPKLEAVPGFVCDICCEDEDGLQTFAMKCGHRYCVDCYRQYLTQKIKGEGEAARIQCPADGCGRILDSRSLDLLVTPELTGRYRELLNRTYVEDKDIFKWCPAPDCPNVVECGIKRKDLDKIVPSVECLCGYRFCFGCPNADHQPAPCELVKRWLKKCADDSETANWISANTKECPKCSSTIEKNGGCNHMTCRKCKYEFCWMCMGLWSEHGTSWYNCNRYEEKSGSEARDAQAKSRTSLERYLHYYNRYANHEQSARLDKDIAQKTEKKMVQLQTTSGMSWIEVQYLNSASQALQTCRQTLKWTYAFAFYLARNNLTEIFEDNQKDLEMAVENLSEMFEKPIVELSDSKLKVDIMDKTSYCNKRRVILLEDTAENLAKSKWTFNADLTAPSVASARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU60</accession>
    <name>A0A7D5UU60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g044500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986257.1">
        <property type="nucleotide sequence ID" value="XM_066130348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU60"/>
    <dbReference type="GeneID" id="26240347"/>
    <dbReference type="KEGG" id="mbrn:26240347"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43429" checksum="5D35510E6BC2025B" modified="2021-02-10" version="1">MAPSTNQLEEALINGTYHVFTAEPDATTVNKVRKHVEESMGLEEGFFTSDDWKQKSKALIKQYVDKLLDGWLPESKPERQSENRTKRDASEGSPSSPKRQKHAAQNGQHTTQDEEPHGSDKEAKSKSKNVTSRRQSRTVDSAKDSSDNLEPPLPKKRKQKGNGASGKAQKGSPSIGEEDDSKDDAMSSIEVEVSNSVVNEEEEYSDVIDEGPKPKRKKNQRRDSSPKPAKPKVKKTTESTPDDPDEAEIKKLQSQLVKCGIRKLWHNELKKYGDDARAKIRHLKKMLTEVGMDGRFSEAKAREIRETRELLAEAEAAQEMNRLWGMGTGGRASRSKNKSTKVEESGGSEAEDAGGNGSTDDKDEEEGTSFAARRRRAQADLAFLGDDSGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVH5</accession>
    <name>A0A7D5UVH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g040120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547362.1">
        <property type="nucleotide sequence ID" value="XM_014691876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVH5"/>
    <dbReference type="GeneID" id="26239925"/>
    <dbReference type="KEGG" id="mbrn:26239925"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="226" mass="24320" checksum="5918E7336598E1E4" modified="2021-02-10" version="1">MEDTYRALSERLRAKWAEKKALGQARLVVAIAGPPGSGKSTMASKVVEHVARSDNAPSIVAVSADGFHLSRRALRALPNAQHALARRGAPWTFDGEAAAELACRLRTEAGRSAVSAPTFDHALGDPVQNGVTIAPETEICIFEGNYLLSDEAPWSAIGDVVDDRWLVRVDVEVAKRRLAARHLDAGIEESMEDAVARAESNDLVNGEYVMAHSFGRHDVLIDSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW77</accession>
    <name>A0A7D5UW77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional protein GAL10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GAL10_0</name>
        <name evidence="4" type="ORF">G6M90_00g044490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547783.1">
        <property type="nucleotide sequence ID" value="XM_014692297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW77"/>
    <dbReference type="GeneID" id="26240346"/>
    <dbReference type="KEGG" id="mbrn:26240346"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="340" mass="36228" checksum="C4C15E9CE2CCE8AE" modified="2021-02-10" version="1">MPDAPFAFLPLGAIIQSIKVNDTNIVLGFPTQEQYVQYNTAYFGETVGRVANRIKGAQLDSVNGKVYPLAANNGPNTLHGGNVGWGKRIWKGPAPVGIKQIPGVQGLQGGESVTFTLVSEDGDEGFPGTVAAKVTYTTGTQVVDGKEVLLLGIEYEAELVDGADETPINLTNHSYFNLTGSADIEGTVVTLGSKLLLPNDEFSVPTGGPVPHASIDTTQPFTLGATDPQVDNCFTKTAEPASVPIDTRSQPLVRDLAAHHPQTGIHLEVLSTEPSFQFYTGDFTNVPAVEGASAKGGRSAFCCEPGRWVNAVNVPDWKSMTMLKRGETYGSRIVYKAWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWB2</accession>
    <name>A0A7D5UWB2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g031140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539627.2">
        <property type="nucleotide sequence ID" value="XM_014684141.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWB2"/>
    <dbReference type="GeneID" id="26247538"/>
    <dbReference type="KEGG" id="mbrn:26247538"/>
    <dbReference type="OrthoDB" id="5243355at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028872264" evidence="2">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="110" mass="11684" checksum="28B9B226953A52D1" modified="2021-02-10" version="1">MQCLRAALMLLIWLLLDAGASPESTHSSGDSLIKSTVLGSHRDVVGMLIDRMANIRHPDGLGRTPIRAAVGRIRNAALVRLLADSGANLSETDSDGRNLLHVAVNGHPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWD0</accession>
    <name>A0A7D5UWD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sme1</name>
        <name evidence="13" type="ORF">G6M90_00g056280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544221.1">
        <property type="nucleotide sequence ID" value="XM_014688735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWD0"/>
    <dbReference type="GeneID" id="26242633"/>
    <dbReference type="KEGG" id="mbrn:26242633"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="96" mass="10689" checksum="9EC553D675CF8834" modified="2021-02-10" version="1">MTGRGGGGGRRVLLPPINMIFKLLQSNATVSVWLYEQLSIRIEGKIRGFDEFMNLVIDDAVEVSQVTKTNDKETRRQLGQILLKGDNVSLIQSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWE7</accession>
    <name>A0A7D5UWE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g048510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544966.1">
        <property type="nucleotide sequence ID" value="XM_014689480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWE7"/>
    <dbReference type="GeneID" id="26242307"/>
    <dbReference type="KEGG" id="mbrn:26242307"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="42"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="263" mass="28440" checksum="734937F7257B4AC3" modified="2021-02-10" version="1">MASATGLPERPPARESIVAAETEPLLGKPGDAVLPTGASIMRAFVIGTGTLAQLGVAIICADIWAHMFFSPIIFFSGHPIAMSAAVFTLTQSVLVQQPISSDTPHQKRVGQYVHAALNLFAFAAIVTGFAIIEINKFRSNGPHFHSAHAYLGVFTLVVLAGQYVVGLTMWATPRLYGGEERAKSLYKYHRYVGYLILLTLLATVVAATETDYVRSVLGVNFWTVLAGSVLVVMGVFPRIQKQKLGLGPRQEERPVHDFESATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX67</accession>
    <name>A0A7D5UX67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g053020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540428.1">
        <property type="nucleotide sequence ID" value="XM_014684942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX67"/>
    <dbReference type="GeneID" id="26246790"/>
    <dbReference type="KEGG" id="mbrn:26246790"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
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    </dbReference>
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            <dbReference type="EMBL" id="QLI68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21582" checksum="2305CCCC4061DEA8" modified="2021-02-10" version="1">MNADVRRVVDFWFNRPPMEWIIAPEGLDAQIKSEFGQLVLKARNNELDDWTAAPEGSVALVALLDQFSRNMFRGSPDAFSADAKAWDIATKAIAREFDSKVTVIQATALYMALMQQESLISLIAARQLFKALKPRCATEEEHKWVDMGVAASKRHMQQLEQFGRYPTRNALLGRKNTEAEEEFLKAHAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Metarhizium brunneum</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
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            <end position="167"/>
        </location>
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            <end position="224"/>
        </location>
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            <begin position="265"/>
            <end position="450"/>
        </location>
    </feature>
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            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="721"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="535"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
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            <begin position="211"/>
            <end position="220"/>
        </location>
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    </feature>
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            <begin position="305"/>
            <end position="342"/>
        </location>
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            <begin position="358"/>
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        </location>
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        </location>
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            <end position="609"/>
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            <begin position="661"/>
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            <dbReference type="SAM" id="Coils"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
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    <name>A0A7D5UXQ8_9HYPO</name>
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        <submittedName>
            <fullName evidence="8">UV-damage endonuclease</fullName>
        </submittedName>
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        <name evidence="8" type="primary">mus-18</name>
        <name evidence="8" type="ORF">G6M90_00g064210</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UvdE"/>
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        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <end position="157"/>
        </location>
    </feature>
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            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
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            <end position="220"/>
        </location>
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        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXS9</accession>
    <name>A0A7D5UXS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">G6M90_00g060800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986733.1">
        <property type="nucleotide sequence ID" value="XM_066130706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXS9"/>
    <dbReference type="GeneID" id="26243060"/>
    <dbReference type="KEGG" id="mbrn:26243060"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="590"/>
        </location>
    </feature>
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            <begin position="43"/>
            <end position="59"/>
        </location>
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        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="590" mass="65369" checksum="0E76FACED13D58B6" modified="2021-02-10" version="1">MLIRIDVFTTPTRPVCEVEPAIIPNASPRRHLKHSDNGDRDPVNSNGQSRDGATKSQNIRPGVVDITPKRPQVRSPNCVAGVETPMLSPFEMHPVIFSPPEPLYQSSVRSVPKRTSLEAPYSSCSTQHNRRYTTNSAPLEKTAELLKLLDTSTANVEESSTEKDGLASRVQVRPALAMQEEIADQRSSLQALGGYVHKASAEEINDKLREMLAAIDALKPPTPQKIQAPRKLYRVASSRVFARMSDAFGRMYNKSASPEVRTRDQENRTRLEETGMPIKRSLSQADSSQHSIRSIEIRLNEGSNLDRRKVQQLIGGPVFQKPVAMNEMSTLCRKSDGRTNIPESAMPMGRRESKLRSFSSSMNPFEAEEDFENDLENGILRASPAGSSTPRICTNRDSSSSYGDDYVDDLSGSSVGQVNLARVVVKVGKNNVGTPKIRQVNLQSPANVKDCSPKPWQRSKRGRDMQYDDDFGIAKKHPSPSKRDLEELELAFQRYKLPGLHAEDETDELAKSNASLGEVLTAKDPNKKMLRNQITQTKTTPGQQRPMSKTAPSRIPRPSSLVAKRKVTGIRPAAGYRPKNAVLGEPDELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ95</accession>
    <name>A0A7D5UZ95_9HYPO</name>
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            <fullName evidence="3">pH-response regulator protein palI/prr-5</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">prr-5_0</name>
        <name evidence="3" type="ORF">G6M90_00g074290</name>
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    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26241670"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF7">
        <property type="entry name" value="PALI-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="230" mass="24949" checksum="B23976C4D35CBB22" modified="2021-02-10" version="1">MGVGKFIHHIGTFLLFVSFVLLIVVDITAPVINNLSIMKVDLGRNRAGADQVTFGTFGYCLRGIDDSDECTHSRIGYDPANLMNRLDGTDFGDASATTAKGLTRVMVLHPVATGLCFIACLLCIFTGTVGSFLASLVSLITFVVTLVAMVCDFVTFSIIKHDVNQNGVSTASWGSGIWLILASAIFTLFGAAIVFVTCCCARKKKSSERQKENWNETTTTPASGRKRRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZK3</accession>
    <name>A0A7D5UZK3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ubx1</name>
        <name evidence="4" type="ORF">G6M90_00g063320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687065.1"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:autophagosome assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SEP_domain"/>
    </dbReference>
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        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="220"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="337"/>
            <end position="399"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
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        <location>
            <begin position="116"/>
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        </location>
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            <begin position="301"/>
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        </location>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZL2</accession>
    <name>A0A7D5UZL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cell division cycle-related protein res2/pct1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">res2</name>
        <name evidence="10" type="ORF">G6M90_00g078760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014689746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZL2"/>
    <dbReference type="GeneID" id="26241265"/>
    <dbReference type="KEGG" id="mbrn:26241265"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="674" mass="75637" checksum="CA539822D13906AE" modified="2021-02-10" version="1">MVKAGVAAVSAGPGIYSATYSGIPVYEFQFGADLKEHVMRRRHDDWINATHILKAAGFDKPARTRILERDVQKDVHEKIQGGYGKYQGTWIPLDSGEALAQRHSIYDRLRLIFEFVPGNESPPPAPRHATKPKASKAKPAQPPPPPKWGAGAVMARHEEFDNGDTLMGEDDTPDNLTVASASYMADDDHFDMSHMPTSHRKRKREEHMQDLTEQQHAVYGDELLDYFLLSRNEQPAVKPDPPPNFQPDWLIDAENHTALHWASAMGDVDVIKQLKRFNSNIAVKNIRGETPFMRSVNFTNCYEKQSFPAVLKELFETVDSRDNSGCTVIHHAAVMKNGRVFSPSCSRYYLDLILNRLQENVDPSTFQQMLDVQDNEGNTALHLAAQRNARKCIRALLGRNASTDIANNEGIRAEDLIMELNAAKKERGPQRSSSPFAPDSQRHASFRDAFADNKKKPPTSFQSAAATTVQSRIAPLLMEKFQDLAKSYDDEWHEKDVAEAEARRILANTQADLHATHQQIAELEAQLETDDEATKIMGEANRCKHQVLSLITHQSRLHIHQAVESDMNRVNGDNGENDSYDERLALARQLNSLIGELRQAENDYVDALSMVGTGDKIEKYRKLLKRCLDQKDGEMLDSNLDNLIEMMEEERDVNDVDGAMVSAGDPMDFGVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZL7</accession>
    <name>A0A7D5UZL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g080610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI70373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014683906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZL7"/>
    <dbReference type="GeneID" id="26247836"/>
    <dbReference type="KEGG" id="mbrn:26247836"/>
    <dbReference type="OrthoDB" id="2212170at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI70373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="138" mass="14902" checksum="C51D83016D76B5D0" modified="2021-02-10" version="1">MTTTGSCACHQIEFQYSGNPVLTALCHCVDCQKWTGSAYTSNAVVRRDSFKVTKGTPKIWDIAGDTGKNNRHFFCSACGSSLYSEPEAMPDKTLVKAGTLDKGAASLGGKIDIELYTKDRVGYMTAMRGAKQEAAFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZP9</accession>
    <name>A0A7D5UZP9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g079510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539923.1">
        <property type="nucleotide sequence ID" value="XM_014684437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZP9"/>
    <dbReference type="GeneID" id="26247261"/>
    <dbReference type="KEGG" id="mbrn:26247261"/>
    <dbReference type="OrthoDB" id="4135672at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16643" checksum="B38F65B90557F1EF" modified="2021-02-10" version="1">MSYNVFLVAYLGAPRNHHGLFIKTDLASKCGIHLHVKGDIQNGMELEEKSTNNPETSANFVEISPLGWVAAGDLDPMRHICMSIPAPKKQFNSSKRLYPKEPLRRCQERTNEAIDSLARDVSYEWATDGQSSSVGQTKKRKGKGKGRGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZX2</accession>
    <name>A0A7D5UZX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g068480</name>
        <name evidence="3" type="ORF">G6M90_00g069230</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986953.1">
        <property type="nucleotide sequence ID" value="XM_066130875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZX2"/>
    <dbReference type="GeneID" id="90967896"/>
    <dbReference type="KEGG" id="mbrn:90967896"/>
    <dbReference type="OrthoDB" id="4692478at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15206" checksum="44C00173E4D77692" modified="2021-02-10" version="1">MKTPVDKQWKQRTSGIMKKAHGMHWTFGVKVALYLERDGELFVYRSHEDFAWEAATFLAKQILTPNDFITLAQDMSSRRAQQSTPLPSSEQGPPQTPVSSSIPTPVSTPGSSECSVTGSRAPRRTRSHATTLFNIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0S2</accession>
    <name>A0A7D5V0S2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MUP1_1</name>
        <name evidence="6" type="ORF">G6M90_00g073940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545671.1">
        <property type="nucleotide sequence ID" value="XM_014690185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0S2"/>
    <dbReference type="GeneID" id="26241704"/>
    <dbReference type="KEGG" id="mbrn:26241704"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="535" mass="58632" checksum="1FDEFCF972937523" modified="2021-02-10" version="1">MDRLVGGAHAEGKDTVKVHPSDASSGPDTENGQLEIARENKRQIGIPSASMLIFNRIIGTGIFATPATILAQCGSPGLSLMIWLVGMLIAAAGTAVYMEFGTGLPRNGGEKNYLEFVYRKPKFLTTSLYTGYVILLGWAAGNSVIFGEYILHAAQVDVTRWNQRGIALACLTAAFLIHGTALKWGIRLQNFLGILKILVIVIIVISPLVNLKKVRENNTFSKPFEGTTGSAYGVVTALYNVIWSFVGYSNANYALSETKNPARTLKFAAPLALGTISVLYMLANVAYFAAVSKEEMLESKRLVAASLFRNMFGESAERALSVFVALSAFGNVLSVIFSQGRLVQELGREGVLPFSRFWASNRPFNAPLAGLFEHWLVTAITILAPPSGDAYNFVLNLISYPLAIINTFVAGGLIHLYRNRAARNWNPPLKATLPVVIFFLLSNIYLVVAPFVPPEDGQSVYESLPYWIHCVVGFGVILAGGLYWLIWAVILPKIGRYELVRETVVDDIDGWEKSYFFTRPLGERTKDTQDPNGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0W1</accession>
    <name>A0A7D5V0W1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-hydroxyacid dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g067960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540553.1">
        <property type="nucleotide sequence ID" value="XM_014685067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0W1"/>
    <dbReference type="GeneID" id="26246660"/>
    <dbReference type="KEGG" id="mbrn:26246660"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000203">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase (SerA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF269">
        <property type="entry name" value="HYPOTHETICAL D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="26"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="127"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37628" checksum="034250353C302985" modified="2021-02-10" version="1">MAPATRKPRLVIMGSREYHIQDFVADYQHEFEYSVLDAQNRQEALAKLPQDVAQNGPIDAFIIRVGTSEFEPFDEELLGPLAPSCKIIASASAGHDEFDVDWMTRSGMWFCNTRDAVAEATADMAMFLTLAVLRDAHRAERGARSGSWKAGLVPARDPSGSTLGIVGMGTIGKHLARKAAAFNMPVRYYSRRRLAPAEEARHAATYCPTLERLLSESDVVSVNCPLTEATTNLISHREVGLMRDGAFLVNTARGAIVDEEALIQGLESGKITRAGLDVFVNEPDINDYFRTSDRVICQPHMGAVTTEAFRRGERECLENLRAFFRTGRPLAPVNEIAAVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1G2</accession>
    <name>A0A7D5V1G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g086130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987419.1">
        <property type="nucleotide sequence ID" value="XM_066131282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1G2"/>
    <dbReference type="GeneID" id="26246160"/>
    <dbReference type="KEGG" id="mbrn:26246160"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="175"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="616" mass="69409" checksum="E1E95DDBCCF22FD4" modified="2021-02-10" version="1">MLINNNGIRSRRNGIDGSKAIIGAISGDTVEGIAVIDIDILTIFHASQNREKGGKALTSVLKQKRDDLMSENDQYRELFQLLCTKPWDEALELFRHIRESGEPFILFEAVRQAEVLFPNPSPSETYGNYQLERLDRLALDGSIIKVPARPWTIVAGDGLVSELITNLFHFNGTYLLPVLEKDVFIEDMKSGHVIGSRYCTPFLVNAICAVESNFSERAKQFGVIAKQNLSDRFFEEAKGLYEREQGCASIPNIVALVLMYLTMAIKGRDKISRIYLYTAYALLSRLSLEEKFQALESRPGSQKEKCIISRVLWGLYIMESRIAFYYSHPSILPAPKVPKPPDEFGTANMDVLGRLYDEATSAVPLVPGINTINCNLTELWNELMQYVCEGAITGSDSDLRIRKSFYCRLLAYVAQLPPRFHCWSNMTPETCMKRMHETEIIFTILRDVPLDTPFHNLYDLPGTTVRDILRKRCIADVELIGVYMNKWQSLGGLAYRHIHLCMYALIPLLDDSATHPAFSTACMIAQQGINRMKVLGYLLQGIQAFAWAMGKTIPESARRYLHGWGVEAIEPDLPVSFVLPQPDNVKEALARNSGPLLEEVEGQLGSLIELWARLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1P9</accession>
    <name>A0A7D5V1P9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ureidoglycolate hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g074660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545602.1">
        <property type="nucleotide sequence ID" value="XM_014690116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1P9"/>
    <dbReference type="GeneID" id="26241635"/>
    <dbReference type="KEGG" id="mbrn:26241635"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI70892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35596" checksum="2141A79EDB139451" modified="2021-02-10" version="1">MGVENDTSSRLDNLSAASLQPGENPYSAFINACHDDPAEIQLLYSAHRTRRNAAQRDKFLAPDFAGLSIDQTLLRLERAHVEPGFEDERNCLVFWARPPDHVERLAAKLQHLLRRAAPGIWLMPTHRMHMTTLEVAFSKTAAEMGGLVSALRPSIPGIVSWTHLHRARLVKPMVSYDTSAFAVSFLPASGEEALSPGPTRPDAPADDVVQGDGYTYHHLRRDVFGKVCEAGVQVGSRYQVPSAHVTLGRFLDEADHDTPEKRAAWVAAVDDVNAWLEREVWDRKDAEYIGEWVVGHEKGLDARTGTLWYGGGRTILLGEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2B0</accession>
    <name>A0A7D5V2B0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GPI transamidase component PIG-S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gpi17</name>
        <name evidence="12" type="ORF">G6M90_00g094970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987598.1">
        <property type="nucleotide sequence ID" value="XM_066131488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2B0"/>
    <dbReference type="GeneID" id="26246471"/>
    <dbReference type="KEGG" id="mbrn:26246471"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI73050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="540" mass="58969" checksum="A25BC4AC373C1CFF" modified="2021-02-10" version="1">MASEITVDASVPAQEAAAQPIAKQPPPEKPAHTRRRTHVILSFWLIVLVLGLPIWWKTTSIYRADLPLERMLQWADGKACRPAFPLQISVRADSIADQEAQHLVRLTQHALDDLNDFPGHHLRLKLSPKSDTKPPNLSRQDADSALTINLTPGDANSAQLSQHSAVLDMTYAPNSIPSLHSASSALAAYMANELQSTFSEEQSIISYLLSTSSMSSTARQHGLGQEAAESLKKRTTRSLRYAPTYHLSFSLFTDGATPNTWDIDAAINEYMKPMLDVLGPIHNFTIDTQVQLYATPGVQSQILNKEHLASFINAAEWPLSPSIGGAPTVNFIIFVGNQTIGSDSAQVENSQSWMIPQWGSVYLLPLAPTEQHVSANALKQPLLMFGGHLLTLLGTPQSGSLPLRLSSLARVRTMDLLLRASSSLGSLARLSPSLPSISIPRSVAEGVSSSLQHLEQACANLGGPEGLLHARVAEEEAERAFFEKSMVGQLYFPDEHKIAVYLPLLGPVGVPLVLGLVNELKNWIRKRKQKAKEAREKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2B8</accession>
    <name>A0A7D5V2B8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidomain esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cesA_1</name>
        <name evidence="3" type="ORF">G6M90_00g100720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546277.2">
        <property type="nucleotide sequence ID" value="XM_014690791.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2B8"/>
    <dbReference type="GeneID" id="26240700"/>
    <dbReference type="KEGG" id="mbrn:26240700"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF31">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028880610" evidence="1">
        <location>
            <begin position="28"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="250" mass="26973" checksum="65C22B92436CABB5" modified="2021-02-10" version="1">MSPLLQTFSLLAVASLAFITTAQSSSASMPETDAAKDPLRIMPLGASITYGQGSSTGNGYRNDLHKLLTDSGYTVNMVGSRKHGSMKDNDVEGWPGFLIDEVQSKAEAAVPSRLPNVFTVNAGTNDCGRNFQLDGAGRRTDDLLEYLWRASPDSTIILSTLLINLYPVVEARVEKVNAQIKEVARQKAAQKKRIVLVDMHAADGPQKADLADATHPNDAGYNKMAKIWFRGIQEAASKGFLKNPKPVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2F3</accession>
    <name>A0A7D5V2F3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino-acid transporter arg-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">arg-13_1</name>
        <name evidence="12" type="ORF">G6M90_00g099900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546359.1">
        <property type="nucleotide sequence ID" value="XM_014690873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2F3"/>
    <dbReference type="GeneID" id="26240782"/>
    <dbReference type="KEGG" id="mbrn:26240782"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="27"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="241"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="333" mass="36187" checksum="096533BB1E065C11" modified="2021-02-10" version="1">MDHAQIAAQPSSAMPTELALRGSSALIEAFEGIVYGSIAGIVGKYIEYPFDTVKVRLQSQPDHLPLRYTGPLDCFRQSLKADGFLGLYRGISAPLVGAAAETSSLFLFEKVGREVLLATGLASREKGLSVPALWVTGAFSGVCASFVLTPIELVKCKVQVPQHADGAVAPAMRPLAVVRNVFRHEGLRGFWHGQMGTLIREGGGSAAWFGAKETVTSLFYNMKTRAAKSLDEARRIRAEPLPLWQQAVAGASAGVSYNFLFFPADTIKSRMQTIAVGTLAQKRTFWDEGLAVWRQYGVRGLYRGCGITCLRSAPSSAFIFMVYDGLKRNFPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2P9</accession>
    <name>A0A7D5V2P9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cystinosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CTNS</name>
        <name evidence="8" type="ORF">G6M90_00g096730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546663.1">
        <property type="nucleotide sequence ID" value="XM_014691177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2P9"/>
    <dbReference type="GeneID" id="26241086"/>
    <dbReference type="KEGG" id="mbrn:26241086"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI73038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="281" mass="31539" checksum="DAE9BC708F25D666" modified="2021-02-10" version="1">MSLLTFFSGLFGWIYTFCWSASFYPQLILNLRRKSTSGTTVDFPFINVLGFVAYFVSNVAFYYSPLIRSQYAARHNDLTPTVQFNDITFALHASVISAITLSQYLLRTLWGFAPSTGTRPSRFIVGVALGCLFGVVATYLIVASEAAKGPIDPATDWCELDIIYAVGYVKLLITLIKFTPQVLANYSNQSTKGWSIWQITLDFAGGGLSTGQQCIDSYLQRDWSGITGNPVKFALGNVSMVYDCIFFAQHYIFYRGSHSKDRSEEDALLGDEEQQRRRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2V2</accession>
    <name>A0A7D5V2V2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g089060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542211.1">
        <property type="nucleotide sequence ID" value="XM_014686725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2V2"/>
    <dbReference type="GeneID" id="26244725"/>
    <dbReference type="KEGG" id="mbrn:26244725"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="199"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="617" mass="68676" checksum="548D0EF1B17F18D1" modified="2021-02-10" version="1">MTELAQTQGLASSSSDCIPSEPDAPSIAPSLTYSEESEDQEEPTSRVQPRQRRASTRLIAQNARDIQRITGETTAEFVGRCCGGGCCLMGGSRRSGVEYETVPLPDNAAFRSLGLKIGDIPTTLTKIVEMPEKTISFKSISKPRSAPSPTDSAISLGFDGESKPTDASPVLDNASLSQTLSSIDTTIQPPRFVQPHPPYHVYPAKIHTARELTKDGAEKRTYHFDLDITDYPEEDGNDFKVGGAIGVMAPNCELVVEDVLDTLMVPRFIRDKPIMLTTTKGRWPTVWGDDKARELVTTRRDLLTWCTDLQSYPPTKPLLRVLAEHATAENEKKILMFLCSSEGQGSFCDFRTGPHITVSQLLNAFPSSHPPMDELLSCLQPLMPRFYSLSNDPHESFQIRDQKRHRLIEIAVTVHETNDWKKGCRTGVGSGYFERQARRYIRAQEAGKKSPEFYIPMFKGLMANPLAKQFNSDGPMLLIGAGVGIAPFRGFVQRRLKQANCANKVWVLQGIRDSLVDEIYSGEWGVHEDEVKRVVQSRRGEGQYVQEEVRNQADLVWYIANSVDGRIFVCGSSKGMGEGVEDSLVDVAMSKGNLERDEAKNFWQLKKEAGQYIAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V393</accession>
    <name>A0A7D5V393_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-dependent monooxygenase OpS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OpS4_6</name>
        <name evidence="9" type="ORF">G6M90_00g105370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541524.1">
        <property type="nucleotide sequence ID" value="XM_014686038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V393"/>
    <dbReference type="GeneID" id="26245774"/>
    <dbReference type="KEGG" id="mbrn:26245774"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="444" mass="48845" checksum="8F15DDF2309BEFC9" modified="2021-02-10" version="1">MEYIRETIEWKGRKAVKPLSVIIVGAGIGGLALGIGLQKTGHKVTILEQVHEIAEVGAGIQVAPNAARILYRFGVLEEVVKYANMLERNSLRRYANDEELGSAQLMPDAGNKYGAPLSVIHRGDLQRVLLQAAKDYGCNILTSHKVIKVDDGFEPRVQVQGGDWFSGDVVFAADGIKSSIRAQVAASHGQQSRSSPTGDAAYRVLIPKTEMKHDKEAMSLLQENVGMRYMGPGGHIMAYPIKNNTVYNMVLIHPAKENEAGKETSWTTKGSKAEMMNFYQHWSPLIRNLLSYVPEGEVLEWTLNSHVPLPRWVENKVGLVGDACHPMLPYVAQGAANAIEDAGAITAALTCTSDVKLALRVYELTRKERGERIQASASTVRKTLHLPDGPEQEQRDKSIRAASHGEGNHPDLWADTDWQDYMWGVDVMKNIIESWSELSGQAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3K0</accession>
    <name>A0A7D5V3K0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g107120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987856.1">
        <property type="nucleotide sequence ID" value="XM_066131718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3K0"/>
    <dbReference type="GeneID" id="90968222"/>
    <dbReference type="KEGG" id="mbrn:90968222"/>
    <dbReference type="OrthoDB" id="4933158at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="504" mass="55550" checksum="D71F8DF1EC2CDAAE" modified="2021-02-10" version="1">MKIRQRTICHTCRARKLACDGRSPSCSQCLKSSRECGGYQYGLIFAEPQTTGRRTAGRKRITLSEVAVEPRLPTPGIGQPLSWPMNDILSMVVQNFIPRRDETNAKSQGLTAPSRVCGSWIEVVPDLKTSGPNGHALTASIKAFAVAMTTCRRPLGAPIVDALAAHGTALSSLQQALTRGRNEGPDELSAAIMFLFLSEIMVPACGSYGAHIGGISRLMLSRGPAYYANGTSHRIFIGCRPSQIICFILYRRACFLEAAEWCTIPFQTSPAEPLQELMSIGACIPSLLQAIDQLEATSKHDHFSACIDKLLDIIRRLDGWRYSYSANLSSTYGRDFVAPPTSEDIWYPDITVANSLTHYWAFWIICAVYAIQLDSGGIWSGRLGEANVVQQEAIRSKSNLIMRSVEYLTQKKMKLFGATSLGLPGKVAYEYSQQAGDLNSATFSNKVIKNISEKGYSYLNAFIQSDFKILPLSTPRHQNGDQRGRTISNSTALQLKAQEEREIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V412</accession>
    <name>A0A7D5V412_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conserved oligomeric Golgi complex subunit 4</fullName>
            <ecNumber evidence="4">7.2.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PMR1</name>
        <name evidence="23" type="ORF">G6M90_00g101550</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COG4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="4"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546191.2">
        <property type="nucleotide sequence ID" value="XM_014690705.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26240614"/>
    <dbReference type="KEGG" id="mbrn:26240614"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="21">
        <location>
            <begin position="1208"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="175"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1370"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QLI73091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1819" mass="197440" checksum="C9512ED09987B4FA" modified="2021-02-10" version="1">MQMPWFARNGSGKETLLPTSSTPAITEMSTFDSSENGKPVRPQHARTPSSHARNVADEFSYMTPSEVGARLRTSLTHGLTATDALTRLGDYGPNEIPHDEPEPLWLRFVKQFQEPLIILLLVSAGMSVLLGNLDDAVSITVAVTIVVTVGFIQEYRSEQSIEALNHLVPNHAHLVRGGSSKPSATIPKSPAWPPPSSDPGSTGSSGTKTPVEDAMDAVSTKVMAGQLVPGDLVLFTTGDRIPADIRVTKATDLTIDASNLTGETEPVRVTAEARTRRVSSHGLNHLQLPQPPALGSGGPHEGDPGGDTHNIAFMGTLVTSGHGRGIVFATGGSTHFGTIATSVSGTESPRSPLQLSMDELGTQLSKASFVVIGLISLVGWLQGKKLLEIFTISISLAVAAIPEGLPIIVTVTLALGVHRMARHNAIVRRMPKVETLGSVNVVCTDKTGTLTTNHMTTSEMWYFGAGDPIDVASDSDSMDDKSTPTQLRIMRIGNIANNARLAQKYTESGAAASAVLSSTLGRGQVATNSRWVGQPTDVAMLDMLDKFKEHDIRNSIGPRVAETPFSSERKWMGVTIGSDSKGEKEYAYMKGSVEKVLTACSTYLDNDGREIVLDTARRQEALAAAQIMAMKGLRVLAFASGPVFKSFKGRTAQGTSRTGTPDLESSTSSIPEANEDVYRDLIFAGLVGMSDPPRPGVSRSLKRLMRGGVKVIMITGDAETTALAIGKQLGMNIAVASEHSSSQGTVRPVLLGEEVDNMSEEDLALAMQHTTIFARTNPDHKMKIIKALQSRGDIVAMTGDGVNDAPALKKADIGISMGRHGTDVAKEAADMILTDDDFSTILRAIEEGKGIFNNIQNFLTFQLSTSAASLSLVLLCTFFGFKTPLNAMQILWINIIMDGPPAQSLGVEKVDPDVMNRPPRRRNDAVLTRAVLMRVLTSAVIIMIGTMLIYRHEMLADGQVTRRDTTMTFTCFVFFDMFNALSCRSESKSIFRVDTTVSNLVNKAPGSYVPPGRIFSSPMSSLPNGVFNRYSTTDGKDMKPKTATSSPLNHVSCAAELRAALAALHARESDITARLDSLIASQADLTRDLGRLDLLRAGLGAQVIAARSISNDMLSSAAETAGRLSNRVKELDLEKSRVEDTLGVVEQVAELKACVNGVVGSMGAPQDWEAAAAYLDRASKVPEDIARGAFASSIVPSVEVPDPPWVTLETARESLCGLFLREFEKAAGDGDGPKVTRFFKLFPLIGRADVGLDVYGRYVCQGVAGTARATLKDSVGAHGRKEGFFYANALTRLFEHIAQIVESHGGLVERHYGAGKMVRVIERLQMEADVQGGIIMDTWSDERGIDRMITDVKSYPFSFLVQSFLPQAPRSGTPRVNSPAVGGGNPRSSEDEGVNMKEVDGLLNEIALMLGRWSLYTRFLSGKCMVPSDEDALLVLPELLIKSNLYRKVSAKLTTPYNVMTTFFFRRSVEKAFQLDEYPTGLSLRLNKSIDGHGPIIITAVDDVMYIVNTVIQKSMSTSQRDVIASVIPTIGRVLGSDFIGMVQRKMRDESYPKPAVHGGFPPEDKIIQFIVLINSLDMANEYLSRIIGSRVVAAEGQASGVALHESLKDSFPFDKDNTFAANALHSLETSFINKSSELLNEGIQVLFAQVIKPRLRPIFNDTFRDVDYTLNEEGVAEVAEQNDENVGDILEQVSRRFEHGWDQLMKPIARIMTPGTFRTLLDITARYLSKILEKRILSYAGKTSPFGAVRIERDFGGIVNIVSKGEFRVREAFGKVTQLLMVANMEDDEWEELGNDEDAIEWVLTEEERRRARGLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V483</accession>
    <name>A0A7D5V483_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COX19</name>
        <name evidence="7" type="ORF">G6M90_00g109520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987910.1">
        <property type="nucleotide sequence ID" value="XM_066131782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V483"/>
    <dbReference type="GeneID" id="90968247"/>
    <dbReference type="KEGG" id="mbrn:90968247"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="105" mass="11864" checksum="8AC633FBD0F6FC04" modified="2021-02-10" version="1">MSTFGSPGSLPSTRPKPPQRGSFPLDHDGECREVMTNYLACMKKVRGVNEDECRNLAKAYLSCRMDRNLMAKDEFKNLGFAEPSKPDQTKTQPEPEKGVKGELRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4B8</accession>
    <name>A0A7D5V4B8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Apoptosis-inducing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aif1</name>
        <name evidence="11" type="ORF">G6M90_00g113200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539784.1">
        <property type="nucleotide sequence ID" value="XM_014684298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4B8"/>
    <dbReference type="GeneID" id="26247449"/>
    <dbReference type="KEGG" id="mbrn:26247449"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="542" mass="57517" checksum="A3F585E9819EA8AF" modified="2021-02-10" version="1">MAQEFKLKDLTSLSLSPGSKQEVEVDGVDGGKVLLVNTGGRIQAMGAKCTHYGAPLAKGVLTADGRVKCPWHGACFNTSTGDVEEAPALDALPVFKVTERNGAVYVIGDESAIKNSRRQPNLSCAGASVADEKVVIVGGGSGALGAVEGLREKGFTGGITVISNEGYYPIDRPKLSKALMTDLSKLQWRDKGWFDSGNVEWVDGEATAVNFGERKVTTKNGQNISYTKLILATGGIARTLPLNGFRVLGNIFTLRNVHDVKAIVDAIGDKGKKVVIVGASFIGMEVANAICKDNTVTVADMSKVPLERVLGEKVGAGIQKAVEAKGVKFHLGGGIERAEPSASNPSKVGAVILQDGTKLEADLVILGVGVMPATDYLRDNSVLRLEKDGSVQTDENFQVSGLKDVYAIGDIATHPYSGPGGEGKLVRIEHWNVAQNSGRHVANHIVNPTQNRPLNIPIFWSALGAQMRYCGNTANGWDDVIVDGDPAEAKFVAYYTKGETVVAMASMGRDPLMSQSSELMRLNKMPSKKHIQDGVDVMSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4C6</accession>
    <name>A0A7D5V4C6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine decarboxylase proenzyme 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PSD2</name>
        <name evidence="3" type="ORF">G6M90_00g087340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987484.1">
        <property type="nucleotide sequence ID" value="XM_066131306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4C6"/>
    <dbReference type="GeneID" id="26244898"/>
    <dbReference type="KEGG" id="mbrn:26244898"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF11">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="153" mass="17375" checksum="F8FA355E628D9AB7" modified="2021-02-10" version="1">MPDYHRYHSPVQGEVKTYQSLPGDCYQVDPVALQSKVDNLTRNRRDHVVTETREFGNVLFTAVGATDVGTWKRAYHSAGTKINKRYELGIFQFGGSSIIVAFQHRRIEFDDDLLRSSEQKIQTSVEVGMSLGYATRHLQDQFSPSMFLMTVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4M6</accession>
    <name>A0A7D5V4M6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NMRAL1_3</name>
        <name evidence="4" type="ORF">G6M90_00g094890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540850.1">
        <property type="nucleotide sequence ID" value="XM_014685364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4M6"/>
    <dbReference type="GeneID" id="26246463"/>
    <dbReference type="KEGG" id="mbrn:26246463"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="306" mass="32897" checksum="9E3C7B282BB1231D" modified="2021-02-10" version="1">MSKIFTVFGATGNQGGSVIRAVLADPVLSKEYKLRGVTRDVSKPAAQALTAKGVEMVKADMSSPEAAAPAVQGAHSVFMVTNFWESMSDKIEIAQGKAVTDASKAAGVKHLIFSSLINVTDASNGRLAHVTHFDGKAKIEQYIRGSGLQSTFVQPGLFMSGFFGFIRKQDDGSLAWAMPEGVKADQAQIPLFDAAADTGIFVKAALRSTADGRVIRAATDYYTPSRIVSEFEAVTGKKVAFREVPHEAFKAAFPPAAAQELLENMLLLQAPGYYAGADLKDSLELLGRDKPTTWKAFVEENKAKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4T5</accession>
    <name>A0A7D5V4T5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fusarielin synthase FSL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FSL1_1</name>
        <name evidence="5" type="ORF">G6M90_00g093380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539426.1">
        <property type="nucleotide sequence ID" value="XM_014683940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4T5"/>
    <dbReference type="GeneID" id="26247786"/>
    <dbReference type="KEGG" id="mbrn:26247786"/>
    <dbReference type="OrthoDB" id="5397531at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Beta-ketoacyl synthase-like N-terminal" evidence="4">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="117" mass="13110" checksum="29D00FBDEB0F45BC" modified="2021-02-10" version="1">MSPNRNTSSPIPIAIVGSSCRLPGQSCTASKLYDLLREPRDVRRSFNPDILNLDRFYNKNADAPRSTNIQNKGYLLDEDSRVFNASFFGVSPYEAESMDPQLRVILEAVYKSFESAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V6N7</accession>
    <name>A0A7D5V6N7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Low-affinity potassium transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRK2_3</name>
        <name evidence="7" type="ORF">G6M90_00g113150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987792.1">
        <property type="nucleotide sequence ID" value="XM_066131883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V6N7"/>
    <dbReference type="GeneID" id="26247454"/>
    <dbReference type="KEGG" id="mbrn:26247454"/>
    <dbReference type="OrthoDB" id="5120976at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="372" mass="41165" checksum="F0060A79C33D47A1" modified="2021-02-10" version="1">MAEHPASRFLKDDSDVAIEFLGAQLENGGCVRPADILEGRVRVSSRHPLSFSRFEVHLEAEETTTVTIDEATPHTFSRALLDVACYPSVSQDPGIDNEGSEHIYSIPFFFVMPDGTEFVPFSRHALPPSFNRHNALLSSWSPTPIPDISILYFLQVVLTYKPGKAGTAGTPTTSTVTKPIKFLPYIEVPPPIDTDSFPGEFTLSIQRPIWKNVLHSRLGLAIISVREPQPLAYSSDVARGSTECQLSITIECDLLAFHRLRCVTVTALPTICAKTYFSSKKMLFTVWTVLFEVTSAYGDVGLSLGYPDVATSLRGVFGTSSKLIICVMKICGRHRGLPYTLDKAIMLLDEYGQRSGIVDLKREEWAMSSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPQ6</accession>
    <name>A0A7D5YPQ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI transamidase component GAA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GAA1</name>
        <name evidence="2" type="ORF">G6M90_00g042280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986422.1">
        <property type="nucleotide sequence ID" value="XM_066130295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPQ6"/>
    <dbReference type="GeneID" id="26240129"/>
    <dbReference type="KEGG" id="mbrn:26240129"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="620" mass="68160" checksum="44F59CC3401B33C1" modified="2021-02-10" version="1">MDTYLSSASALSLRRDPRMLKLPPYLSLVCILVGAIWLVLLPLDNYSRRTYISENALLPGQVHTYFGGSEQNIFRAYRRELDTLVNESNYDINNHLEVILSTAGIKVGRQNYTYNSAGKTYNGENVYGILQAPRGDATEAIVLVAAWSSVNETFNGNGVALAITLARYFKRWSLWSKDIIILIPPDSRTGTQAWVDAYHDAHDSNNVASLPLKSGALQGAIAIDYAMDQRFDGIHIIYDGTNGQLPNLDLINSIVNIGGGQMGMQTAIQGMQHHNDSYRDRLMTMLRGMLKQGLGICAGPHSSFIPYHVDAVTLQPYGEGWHDEMAMGRVIEGTFRSLNNLLEHLHQSFFFYLLMQRDRFVSIGTYLPSAMLLAANFTIMAIFLWVKSGQPAAQVQMPVVATFEKPAPAKPTFSKAPGIPPAINSTERDLSLPLGIVAGCHAASVIPLFVLSNVPARLLPSSLAMFCIFSAVLPFIISYLLPVCFTQRTQHFQLTKSLSLLVLGMALATLATLNFSLAFLVGMLASPLTFITPCKNTISKYFVVALLSAVAPPVVVYPATHLAGSSVAEFLQQASFGWNVWAVYTPVVIWCIWWPAWLVAMTNVLSGTSDGAEMFTTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQ24</accession>
    <name>A0A7D5YQ24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g001560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985943.1">
        <property type="nucleotide sequence ID" value="XM_066129511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQ24"/>
    <dbReference type="GeneID" id="26244292"/>
    <dbReference type="KEGG" id="mbrn:26244292"/>
    <dbReference type="OrthoDB" id="4870739at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="259"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI65362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="78642" checksum="E4678BB6304DA15D" modified="2021-02-10" version="1">MSKSLPLGILQDVLAETLKKKEDCLRKRGKVKIQGREIVIRDVLNKLSACITKFISIGDIIVQYDPVHAALPWAAVRFVLQVAVDDPETFDLVLFYIERLVYYITISSIFDVQYLQPKHHLLDVYPQLFEAIETLQTNVLKFLGYLLRHFCSSTIARHLKSIVVSKKDIEAKFQPIEKAWRRVDELSRLATAEKNEEEFEVLQNKLQELYRPIARSADHLEAIQDGLEREARVRILKAISTIPYPVHHETARKGRLERSGAWLLRSNAFIDGRSESLSYVLWLHGIPGSGKTKLALLVADELMQTTKIAYFYCTRSPAERHRGQCDKMVASIVRQLASLRPDQPILGLVVEQYREAIDGFSEFEDQAWSIEESQRVVLELLAEYPAVNIILDEVNYEERQLLMDVLSRWIQKSPNLLKIFISSRDNYDIFRWVELQIQSLLPLKVAADIRNRLGKLPPTLEGSYWEIYNTILESGRHASKLAIFTFQWLLYGQKVITADNFVAIASASLQIEEPDGETGRSDSLEAITTGEILDVCANLVVLHNGVVVLAHLSVREFLEGLTARSVDTMIAARGNDAIAAACLQLFLTGTEAAYDELQEPAVADSPRDTRNTQTPIEEVMDSPSGTKGPQSDDAAESTTAEPALKKDGNDSIDDSSTPGAEDYQPQTTVKAQPPEPKPIRVKIATKMINSDDSHALTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQT2</accession>
    <name>A0A7D5YQT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARC18</name>
        <name evidence="8" type="ORF">G6M90_00g033170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543246.1">
        <property type="nucleotide sequence ID" value="XM_014687760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQT2"/>
    <dbReference type="GeneID" id="26244047"/>
    <dbReference type="KEGG" id="mbrn:26244047"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1760.10:FF:000002">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="192" mass="21815" checksum="25C1DB0D94832B23" modified="2021-02-10" version="1">MPAYNSIFNNDPNPPRLIGNFPILPLRTKTRGPAYTLPIPSPPLPANESPDPDSDSYDILDEVISLFRANTFFRNFEIQGPADRLLVYGILFLSDCLQKIKPGATARDAQKDVMNLALDLNFAIPGDPGFPLNQMYEPPRDRLDAEQLRQYMSQVRQELAARLLARVYADDETKPSKWWLSFTKRKFMGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRI5</accession>
    <name>A0A7D5YRI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g017780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548754.1">
        <property type="nucleotide sequence ID" value="XM_014693268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRI5"/>
    <dbReference type="GeneID" id="26238198"/>
    <dbReference type="KEGG" id="mbrn:26238198"/>
    <dbReference type="OrthoDB" id="5138090at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="641" mass="73389" checksum="A12B9A38D78B6E26" modified="2021-02-10" version="1">MRLHPTDDLDGSSDRRPTLSARLRLSKSHRRLVIILVILFLLLPKYVFNIARVTKVKEHPASNPGLSPEANPAPILASVAAGDSIASHYLPNAVLHAERKALVSSNGKWRVHLTDDSELILETDRDGTWSPVWWTNSRRYRRKDSAPETSYMTIDAGGAVQILARTMDGDRHAATDRRWDSVLSGRCLPVEGDAMLLAAPGPQSLALDNHGRLLVFDGESKLACLLYDDTFDQSPTLHQTVNLTIAEEEQPDPEQNRWPMFKNSDKLSSLQLRAMLEADLAKTNESLKLSRKQLETVFNTAIVLPSFHGHFEFCIKFLRSMIRHCVDCHLWQINLVLVSEDVEQFSEELFGAGKESIGYYLPGLRIIEYESLPFDYYSPEMDVASITKSMDKFLLQNFKKMYGCLATGRRYCFILDSEGIMLRTTRLADIVREFLDQPFAIHTPESRNGSSHPIGWSTPCADMLRVDNFSSAGWLLEYYMWVFDSRVYAEIARIYAQSWPQLEGNPQEVFFEVCYFAYIWAEKGPVQGPAYRFITSKQLLGQRLWNLMWPRYVYETGADPNERVNGLSIIEDVREWLARFPNLLIPVAEAWERNHMRLFKAGQDWWQAMAFLSVAKSVRMCVSEQPRDLYEAAIWGHFNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRW6</accession>
    <name>A0A7D5YRW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g043230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547657.1">
        <property type="nucleotide sequence ID" value="XM_014692171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRW6"/>
    <dbReference type="GeneID" id="26240220"/>
    <dbReference type="KEGG" id="mbrn:26240220"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="29116" checksum="5B353CB414CF8C25" modified="2021-02-10" version="1">MSKPTYTLAAVRLDDVPEIGQLTADAFVDDRQTQMKNMGKEPYDMNKMTLESLPSMLHNPRCIAIKVVDKDSGDIMGVCNWGFRGFKPEEMPKMEGKPLPLEKPEETKAGPEEKKEQGATDGNGKERLDREEETDPITRLQARTGADLEAWMEEVMPEGTRCLFVIGLSVSPKHQGRGVGSALLRWGTDICDDQGVFAWVHSSEPAWPMYEKCGFRTVRSLDIDLDEYAPAPPPNEGPNAKWGHYVFRYMKYFGNKGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRZ7</accession>
    <name>A0A7D5YRZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g060280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986824.1">
        <property type="nucleotide sequence ID" value="XM_066130696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRZ7"/>
    <dbReference type="GeneID" id="26243010"/>
    <dbReference type="KEGG" id="mbrn:26243010"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="216" mass="23919" checksum="28A01E18E50A9210" modified="2021-02-10" version="1">MAADEEHEGASIKELLIEACRRNNTDLLLEVLHDKPDAEITALLNNTTTVMGNHLYHEAASHGNYEIIDLLLDQPSFECDPINRLEGDTPLHTAIRWLNAEPPAQRAFGKALVEMMLEAGSNPRVKNKGGLTALQLVDPRNAELRQLIQQHEYTNQNAGDFITVDAGAANNKGSSNHAAAVGQQGDGGDDDDDAEFSGSDDEERAEWERRRRERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSY6</accession>
    <name>A0A7D5YSY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549887.1">
        <property type="nucleotide sequence ID" value="XM_014694401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSY6"/>
    <dbReference type="GeneID" id="26239331"/>
    <dbReference type="KEGG" id="mbrn:26239331"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44457" checksum="8EC0F668491B9F55" modified="2021-02-10" version="1">MFLMEELHFHVASGHGKKAYFDSSPSIFWKLFSERVEVNMGDMPNSSGSGSRPRTRQRAYKPPPPLDVPDIEEDAAERKRILNVLAQRRYREKKRQKRMRGSSDSKSTSQEPEDEHAQLVEEIPVDTIEPVDTGIQSPGSIFGIDMCFNNWDMLTDPTLSSMMPDVIGVFSDFPTAAAVDDGSGGGGGDGILTASSSSGSVPPFTTMSNVMFGSPPSLDSSSNSSSDVSFPDSYLLPVHELTLLRAMLRIADRLGCKGSLWSLDALSPFNQGIATPPDQLPRPWRPTPSQVLIPHHPLFDFLPWPSVRDKIIGILSLPDDARPATASGPLALVNFAYDFEDNAEGVRIYGSDPYDPSCWEVGQVLFQRWWFLFDRDIVDNSNRWRRLRGAPLLALTAPGVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT67</accession>
    <name>A0A7D5YT67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g033330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543263.1">
        <property type="nucleotide sequence ID" value="XM_014687777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT67"/>
    <dbReference type="GeneID" id="26244064"/>
    <dbReference type="KEGG" id="mbrn:26244064"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="44231" checksum="E263CDEB7F0416AE" modified="2021-02-10" version="1">MSPDRYDRGTSRRGVWSHWVPLAITLTVATAGVAAWIWSQRKEDEEDNEHEPGLDYENADYGDNPPYGASQRDSRGPQQPPRLYQQGDDAASYGVATAPSDVSAGGWGARMSGALRRTPSPQHFFDSTGKTVAAGMAAAGAAVGKALASIREEDKAYGENPWQEEADAKKGRAPATGEKSRKTVAIVVSADTKISDISDDGTHELASILSHIPRHNDFSKIKLYILIYAPDLKEPMLDGTSSNLPPPSLSSSFSNIGHDQAQTPGEETKSPLIAPSNTNAAYDAVYSQALSLVDKETTILPFTTPNGHVHILRHIQPDILYLQESLSGDNGSIITTLQTWLRHDITLVVGAESGSGGLADSESEAEKTGKQVEKWWQRPERVGRGRGVVVVDGMRVHDDWARRVQGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YU58</accession>
    <name>A0A7D5YU58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g053560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540479.1">
        <property type="nucleotide sequence ID" value="XM_014684993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YU58"/>
    <dbReference type="GeneID" id="26246841"/>
    <dbReference type="KEGG" id="mbrn:26246841"/>
    <dbReference type="OrthoDB" id="4940612at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028876394" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="293" mass="29784" checksum="65C86EE12F901ED9" modified="2021-02-10" version="1">MIHTLLVTGLMAAGASAQARYASDGFKYVGCVQAKACDFPVKMDLGDSFTVAQCQQACGKNGSYAAAGVNGCYCEDSVSRGAPEYEVTDDSSCSKACKSGDDKAGRCGGPSPADGEQLYNLYQRIPAAPTVPNVTTTRLADKPAAAAGDATPAALKTIATHPTEAASTPRTGADEPHAASFREPTPSAAESRGVAYSNDTAPAPPAPATTAYRQEESKPSASPPSGPCRGRECPEAEEVPSEFTSKFAPGTTANNSPSSPSHSVIVSEGPSRPASVITVALGMAALVLAMGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUJ5</accession>
    <name>A0A7D5YUJ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">vma3</name>
        <name evidence="13" type="ORF">G6M90_00g087550</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542361.2">
        <property type="nucleotide sequence ID" value="XM_014686875.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUJ5"/>
    <dbReference type="GeneID" id="26244875"/>
    <dbReference type="KEGG" id="mbrn:26244875"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
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        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="170" mass="18074" checksum="4846768B9459B889" modified="2021-02-10" version="1">MEDQVFASMERCPMYSSFFGAMGIAFAIIFTTFGAAYGTAKSSIAIFSCGVLRPERLMQNTLCSIMAQILSIYGLVSAVIMSNGIREKMPAHTGFLQLGAGMAVGLCGLAAGFAIGIIGDAGVRASNQQPRLYVGMVLILIFAEVLGLYGVIVSILMITKSTLDVTECRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUN8</accession>
    <name>A0A7D5YUN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g055650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544159.2">
        <property type="nucleotide sequence ID" value="XM_014688673.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUN8"/>
    <dbReference type="GeneID" id="26242571"/>
    <dbReference type="KEGG" id="mbrn:26242571"/>
    <dbReference type="OrthoDB" id="5221171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="209" mass="23870" checksum="3812AFE2D379DA2F" modified="2021-02-10" version="1">MDPNRVWHDPVVEIYSNLITPGVRCSAEAYDLANRRWYCVKVEAEVEDDQWLSSTIATHLGRYYAANREKPPWKTMRMNAEGSLVTFDSQPDDKVDRPIRKSLCYGHKRTDRLPTTAVDNLKNLTYISRSADRCTWNDQDCVFKRIEFDVDVEVIEGEIQTRETLIHAMGRMPAIETNNEMARSFCLVPFSPLSSPTESPGNPAPLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV19</accession>
    <name>A0A7D5YV19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">J domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">JID1_1</name>
        <name evidence="4" type="ORF">G6M90_00g095240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546806.1">
        <property type="nucleotide sequence ID" value="XM_014691320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV19"/>
    <dbReference type="GeneID" id="26241229"/>
    <dbReference type="KEGG" id="mbrn:26241229"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="46"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI72840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="244" mass="27528" checksum="CB59F9395A5AF16C" modified="2021-02-10" version="1">MFTARTFHRASHIYHGSRSSNTRRRHSLSSLRQPGLPEWPASSAPTPHEILGVAPGAPYSKDRFNQLVKMYHPDMSGADARVRHLPQSVRLERYRLIVAAHNLLSDPSYRRLYESHRQGWVYPGPFTGRQGDNRHGFSSKDGTAQSSPSPMRQRPIYASNATVAILLVAFGMLGAALQFKRLAASRRDIRRLELVLQEAIQEEIQAWASVLQGQTKDDRILAFLARRHGVPHQLQSWAASHGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YW14</accession>
    <name>A0A7D5YW14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hsp70/Hsp90 co-chaperone CNS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CNS1</name>
        <name evidence="6" type="ORF">G6M90_00g024240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548157.1">
        <property type="nucleotide sequence ID" value="XM_014692671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YW14"/>
    <dbReference type="GeneID" id="26237601"/>
    <dbReference type="KEGG" id="mbrn:26237601"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="289"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="413" mass="46041" checksum="0ADC9BEB7116CB43" modified="2021-02-10" version="1">MKIEEIVDRMEEASLEAEPSTEQAATPVQDVSQPTKPELPPGMASHRKQTFDEIMADLNKSPLFMTDMEENDEIAALQALNYEGTPLENGTDFKMRGNECFKVRGYVDAREFYTKGIQILSLEERKRTRGEVTRNPEGVEDSAEEIAAQREVLEALYVNRAACHLELDNYRSCWTDCAAALRLNPRNLKACYRSARALLAVGRVEEADDVCARGLALDPDNRGLKEVAGRIVKRAGELDAKNKREADRRALLKRRETLLRAALKARGIPTRTTAQPPEMGDTKLELVPDPDDPRSSLAFPTVLLYPEHLESDFIKAFNETQTLEDHLSYVFPLPWDKEGVYTAAGVTCYVETMGGGVLKMGKRVPLLKVLGTGKVEVVDEVVRIFVLPNDKADAWVNKFKQQKAVEMGKGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWC3</accession>
    <name>A0A7D5YWC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="7 19">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">pgk1</name>
        <name evidence="21" type="ORF">G6M90_00g067040</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="7 19"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539570.1">
        <property type="nucleotide sequence ID" value="XM_014684084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWC3"/>
    <dbReference type="GeneID" id="26247653"/>
    <dbReference type="KEGG" id="mbrn:26247653"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000031">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QLI71061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="417" mass="44389" checksum="DA7B5967919299FD" modified="2021-02-10" version="1">MSLASKLSITDVDVKGKRVLIRVDFNVPLDENKKVTNNQRIVGAIPTIKHAIDHGAKSVILMSHLGRPNGSPNPKYSLQPVVPELEKLLGKSVTFAPDCVGPEVEAIVNKADGGAVVLLENLRFHIEEEGSSKDKEGNKIKADKAKVEEFRKGLTALGDVYINDAFGTAHRAHSSMVGVDLPQKAAGFLMKKELDYFAKALESPQRPFLAILGGAKISDKIQLIDNLLDKVNTLIIGGGMAFTFKKVLNDMPIGSSLFDEAGSKNVKNLMEKAKKNNVKVVLPVDFVTGDKFSKDAESGYATDDKGIPDGWMGLDCGEKSSALFKEAVDEAKTILWNGPAGVFEFDKFASGTKAILDAAVKGCENGKIVIIGGGDTATVAAKYGVEDKLSHVSTGGGASLELLEGKELPGVVALSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWD0</accession>
    <name>A0A7D5YWD0_9HYPO</name>
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        <submittedName>
            <fullName evidence="6">60S ribosomal protein L26-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL26A</name>
        <name evidence="6" type="ORF">G6M90_00g072130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI71081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690364.1"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:large ribosomal subunit"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_uL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="136" mass="15196" checksum="03933E1492EB2D82" modified="2021-02-10" version="1">MAKVSSTVSSSRRKSRAAHFKAPSSQRRVIMSAPLSKELREKYNVRSIPVRKDDEVTIVRGTNKGREGKVTSVYRLKYVIHVERVTRDKASGQSVPLGIHPSNVVITKLKLDKDREDILARSKVGRELSANNKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWH4</accession>
    <name>A0A7D5YWH4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-xylosidase XylQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xylQ</name>
        <name evidence="6" type="ORF">G6M90_00g035610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546956.1">
        <property type="nucleotide sequence ID" value="XM_014691470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWH4"/>
    <dbReference type="GeneID" id="26239519"/>
    <dbReference type="KEGG" id="mbrn:26239519"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051816">
        <property type="entry name" value="Glycosyl_Hydrolase_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43863:SF2">
        <property type="entry name" value="MALTASE-GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="4">
        <location>
            <begin position="197"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="5">
        <location>
            <begin position="525"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="821" mass="91851" checksum="6ACD04F0F3A88CDA" modified="2021-02-10" version="1">MVRMQVQADTQPSAQSSPYVGGRKGDKYRFTVLADGVLRYEWAPDGQFEDRPSAFAVHREPQGVLYYQVRESDAWLEVITARFHMTYNKQEFTPYGFFAVVSGYTGHTWRYGEQGQNLGGTCRTLDGADGRIAVGPGVASRDGFASIDDSDTMLFTEDGFVAPRRAGTGRVDGYLFCYGRDYREAVKALYQISGSQPLLPRWTLGNWWSRYYEYTAESYLELIDMFKSIRVPLAVGVIDMDWHLVKDPVVAAAGVTGWTGYTWNKSLFPNPKAFIKALHDRKLKTSLNEHPAEGIANYEDMYAAMAKALNFDASSKETIPFDCTDPTFLRAYFDILIKHLEDDGVDFWWIDWQQGPYSRLPGLDPLWLLNHFHFLHNKRLQAERKPSEGDGGRPIIFSRYAGPGSQRYPIGFSGDTIVSWDSLAFQPEFTATASNIGYGWWSHDIGGHMLGIRDDDLTSRWVQLGVLSPIMRLHSTKTRWVCKEPWKLPAGSGQGPRDVITKFMRLRHRLIPYLHTMNARAAEEGYPLVQPMYWEYPDRDEAYKVPNQYYFGTEMIVAPITSPQNVATKTGKVKAWLPPGRYIDFFTGVVYDGDRFLWLNRTLDNAPVLLKQGAIVPLDANLVPGNGCDNPDGLEVVVVIGADGKFELLEEDEDRSNASTDKPVAWRRTPISFTQSTGTITIHPSGEGKAPKARDWSIRLLGYKTAQSPEVRIDQAVVKTSTSQEGGGLGLLIKVGKIPPGGSAFIKFGPEVKLAINDPLALADPVVFAAQISYNTKKAIDSILSRKGVSAAVRASEVDATDMDPDLRLVLKEFLLADSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWI9</accession>
    <name>A0A7D5YWI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g003890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542043.1">
        <property type="nucleotide sequence ID" value="XM_014686557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWI9"/>
    <dbReference type="GeneID" id="26245074"/>
    <dbReference type="KEGG" id="mbrn:26245074"/>
    <dbReference type="OrthoDB" id="3899536at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028962630" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="21539" checksum="1E25C3F55C739537" modified="2021-02-10" version="1">MKILFAQVLIPPLLSATALAAPGNTPDERDNDADGSIVFPGGNGYSGWAICGDQVSKQRFPRLQVPAGAGGGCVRYYRGIDMTGVVTELHFFFRDGFRTACDCAAKCISQPASCNNWVWKHTFMPGDGGRRSCTLYSSPNLPGNVTLDYDEAKSSGFRPLSDANNPQVGGDSPLTFLDDAGTKPDPDGVSGFTAIDQNGGLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWU5</accession>
    <name>A0A7D5YWU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NTLS</name>
        <name evidence="4" type="ORF">G6M90_00g030970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539642.1">
        <property type="nucleotide sequence ID" value="XM_014684156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWU5"/>
    <dbReference type="GeneID" id="26247553"/>
    <dbReference type="KEGG" id="mbrn:26247553"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="406" mass="43575" checksum="BD20ED0628421698" modified="2021-02-10" version="1">MPVIRVGTASPATGPTKAATLRHLSDLARRAAAQSIDILLLPEAYIGGYPRGTAFGAVIGDRPYEGREEFARYFDQAADLGDTVGGGAGAGARWVKRELGGDDDLPRGDGTREELEKIASETGVFIVTGIIEKTGGSLYCAVVYVCPKAGIIGKRRKVMPTGTERLCWAQGSPATLKAVSTVIRGQRVNIGAAICWENYMPFVRQALYEQNINLYLAPTADGRDAWMGLMRTVGVEGRCFVVSSNMAVRKDGSAQVASSQPSPTRSRARRSSTFTDQGFEIALPSVSPTRRRRRKSVFDEDGNEIVLGCDESNGAEKNGTSPGAQPKSTVATADGWVSRGGSSIVNPFGDVLAGPQWEDDEGLIFADIDLRECIRGRLDLDTAGHYSRNDSFKFTVAGLDLDPLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXD3</accession>
    <name>A0A7D5YXD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Reducing polyketide synthase hmp8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hpm8</name>
        <name evidence="12" type="ORF">G6M90_00g081260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543365.1">
        <property type="nucleotide sequence ID" value="XM_014687879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243542"/>
    <dbReference type="KEGG" id="mbrn:26243542"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="8"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2432"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="948"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="980"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2515" mass="272667" checksum="9AFA24EC89565C4D" modified="2021-02-10" version="1">MQAPAPSRDDIAVVGLSCRFPGEADTAEHFWDFICNGRNAYSENPDRWTPDAFHYGEKKINTSLPRGGHFMKQDVAAFDANFFNLSKVEAESMDPQQRIIMEVTYESMESAGLRVDELAGSRTGVFMASFTSDYREMLYRDAETAPLYTATGTSNTSTSNRVSWFFDLRGPSFTVNTACSSSLVACHLACQSLWSGETESAIVGGTSLLLNPDMFLYLSNQQFLAPDGQCKSFDESGDGYARGDGIGVVILKRVADALRDGDPIRAVIRGSGCNQDGHTKGFTIPSVEAQASLIAETYRNAGLSLAETRYVEAHGTGTQAGDTREMEGIARTFSQHRTASDELLVGSVKANIGHLEACAGLASLIKCVYILETGVIPPTPSVRVLNPKIRWEEWHLKVPATQTIWPTEGLRRLSTQGFGYGGTNAHLILDDAAHYLEARKLRGHHYTRTHPQTRRLLTSAMHEAVPNDQPPRLFLFRANDREGLGRVRSSLAQHLEQLLKSWPQDSRDGGAYLHNLAFTLASRRSHLQWQTYATASTPSELLQALQQEGGAWAAPETRVAASAPRLGFIFTGQGAQWARMGVELMAYPVFRQSVEASDEFLRSALGCPWSAVDELAKPQATSRLSEAAYSQTLCTVLQIATVDLLEDWNVCPARVAGHSSGEIAAAYCLGALTKHDSLRVAYYRGILSSEMQQTHGDRRGAMMAVGASPEEVEAWLAKLTRGRVVVACINSPTSVTASGDAAGIDELLAMVQEAGVFGRKLQVDVAYHSHHMQSVSSAYAELLKDLAPLPARPGRTMHSSVLGRVIDAAELGASNWVQNLVSPVRFSEAVSSLLSDGDKPAVDVLVEIGPHAALKGPVQQILQAQGVSALKYTSVLSRGQSAVKTALACAGELVLSSVPVAMSRVNLESGPQPSPLVDLPPYPWNRSTRFWAESRLSREYRLRKHARLPLLGSPCPTMGARERYWRGMVRLEEEPWIRDHEIQGSILYPGAGFLIMAIEAASQHAGEQRKVSAFRLRDVHLDAALVVTEDSTAEAILQLRPHLLAPGSSQSSWMEFTVNSSIDGGDLRQNCSGLIMIEYAADADSAMDRERALESDMVCDWYKKTYVSCQQSVDVGKFYSRLASLGLVYGPTFANVTEIRRTGQGQCIGAVRIPAVDSLVPPAYRSHPHVIHPGTLDAVFHLAFAALEDSLLPGPMVPTTIDELVVAADTPNTPGTLLRGVSRSSPHGFRELISDIDMLDDQNSRALVQIKGFRCADVSGGRMTESEAASAESRPIGFRLEWKPAIDLLTGEQLRTYLDHCVKQEGASNVARATELNNHVHHLEETLPRVAVDPAMANLSDWLSAKSAKLTNGAASSSKRPSPGGDMLAMRDALTAVREGSIPSPEQQDKMLREVEQNGALSILLKSLDAYIDLRHHAKPDLSILELSLDSVPYSVFAALPSRHKILQTAQYAIRVSQEGVADRVRAQFGSQASDIEVSAADFTKKLDEALGKHDVILIFDPGFIHAKLEVVLRNARKLLNPGGRIIVAEVGEPGLYLGTALGCLQWTRNLDVAQSSSSWTSCLARSGLTPALKLIDMDTESAVHGHFRLSLTGNAAESANSDNRQPQQVTLIESANASATAQAIAAAVAQNLEKASIPTKRVRWGSDVSQLKGQPCIVLTDLESALLKDPAPEDLAALQSLFSNAESTLWVSGPLGPDAALITGLSRSVCNEAADVHIRTLEVTDLPGPGADSYADLVTRVFRYSGPDTEFRWHSDALLVSRLVEDEARNKEIAQLLGQGEKAAVATTLQEKPEGLKLCMRQIGMLDSVCFEPDLLALEPLEAGEVEVDVKASGVNFRDVMVALGQIPDRAFGFEGAGVVRRVHASETRLRPGDRVVFLAHGAHRTVHRVRADYAMPMPDTMSFEEGAAILLVHTTAWYALVKSARATAGQSVLVHAAAGGVGQAVLMLARHLGLQVFATVGSEEKRKLVHETYGVPHDHIFNSRDASFAMGVKRMTKGRGVDIVVNSLAGEALRQTWHCLAPFGTFVELGMKDILDNARLDMKPFLQDATFVFFNLNRVQKERPDLMGEALRETMALVRSGALKPATPLTSYPASQVEAAFRKIQTGQHLGKLVLTFQAGDVVPVVRPDLSLSDSGTYLLVGGLGGLGRSLARLLVQLGARRLCFFSRSGAASSEARALVKELEMQHRVRVLVCKGDVSDADTVSRVVQQCRAALGPIRGVIQCAMVLRDGLFERMAHDQWTESTRPKVQGTWNLHEQIPVSDFFITLSSFAGVFGSRGQSNYAAAGAYEDAMAHHRQSLGQRAITIDLGIMRDVGVLAENGITDYLREWEEPFGIREPEFHALIKSAIMSTTQPLTERSVVQIPTGLATARSAQAAGISTPFYFDDARFSILAQTRTSAGASSAAGSGDADAGKVSVRTQLSQAHSVAEAAAAVQTVLLERVARTLQSSVAEIDPSRPLHSYGVDSLVAVETVKWMFKTLDAKLTVFDVLSNVSITALCEKIASMSTLVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYK7</accession>
    <name>A0A7D5YYK7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g099430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546404.1">
        <property type="nucleotide sequence ID" value="XM_014690918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYK7"/>
    <dbReference type="GeneID" id="26240827"/>
    <dbReference type="KEGG" id="mbrn:26240827"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF1">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028884813" description="Lipase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="29839" checksum="755D41831DBB724C" modified="2021-02-10" version="1">MKRFTLSALATAAAVAAGAIPTTSPTSPSTSSHNDFSCKSSHNPVVLLHGLGATSCQDLNRLEAWLRTKGLCTFSLTYGAYDGFPLVGGLKPIRESSPQIASFIRNVHRATGSRKVDLVGHSEGAFQALYTTKFGSVNHIVDALVAIAPPTHGTSLAGLYSLAELLGVERGAKDVLGAFGCKACADLVTGGAAVQRLNDGSPIVQPGTVVTVITSKLDELVTPTETSFVHEPGVNNIYVQDYCPADLVGHIGEAYDMNVWNLVLNSLEKKLGRDFSCVLASPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ29</accession>
    <name>A0A7D5YZ29_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g106630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539879.1">
        <property type="nucleotide sequence ID" value="XM_014684393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ29"/>
    <dbReference type="GeneID" id="26247318"/>
    <dbReference type="KEGG" id="mbrn:26247318"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="115" mass="12954" checksum="8F6BC7B1F2B89540" modified="2021-02-10" version="1">MSVAAECQRWLRRKQYTFEVTFALNMFRSWEKSVIYSVLFLLCSMTFIAAVLYLPHHITVLAGRAWYYIKGEHINVAAAAREVVQEVVSKSVAGDAMPTAEAVREAVVGAIEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ86</accession>
    <name>A0A7D5YZ86_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g111120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543750.1">
        <property type="nucleotide sequence ID" value="XM_014688264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ86"/>
    <dbReference type="GeneID" id="26243137"/>
    <dbReference type="KEGG" id="mbrn:26243137"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40545" checksum="3D72B486635A4F88" modified="2021-02-10" version="1">MRTSPDRRTWMVIFSVLATIIILFYGYQSPWTSQLVRHGSNNPSIPNDVHFVYVLKDANADFSFQFKHYLSVYAAWHYWQPQTIYLHTNAHDDSITRARDGASGKWDRLIFGMPNLRINVVPVPSHANNSVEITGMEHKSDFLRVQAIRDFGGVYIDFDAHALRDIRPILKSGFNAVGGREISGQLNSGTFMSKKGAKMISLWHEEMHQVYDGGWVTHSNLVLTRVGEQLVAEPGEMLILDKAALAPVGWEAEDCSMLFEVHDDTPPETGGKVEGQQFHDEGSGRPGGNPPWARDWSSTYILHAFQPDRHGYIIKGFDYNITPRYVLEGRSNFARAVYPVAKHMHENGLIGLDDSHHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZQ2</accession>
    <name>A0A7D5YZQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g035050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546900.1">
        <property type="nucleotide sequence ID" value="XM_014691414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZQ2"/>
    <dbReference type="GeneID" id="26239463"/>
    <dbReference type="KEGG" id="mbrn:26239463"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="297" mass="33086" checksum="9C2B06D79E102440" modified="2021-02-10" version="1">MPALPSSAAPRIISRALRSSRHSPRWTRQLSTHTARRSPSLLRPGFHINVPSRPVVPRRSALPSLGIGGTRSIFIQTENTPNPDALKFLPNHRVVPEEINSPFIEYLNPRSTISPPYPSPLAAKLMNIDGITSVFYGADFITVTKAGDANWAHVRPEIFALITEAITSGETIVSIAERKEGDEDIEEDSLAYNENDSEVVGMIKELLETRIRPAIQEDGGDIEFRGFDDGYVKLKLRGACRTCDSSTVTLKNGIEGMLMHYIEEVKGVHQILDQEEEIAMEEFAKFEEKLKHQKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0L9</accession>
    <name>A0A7D5Z0L9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">qcr7</name>
        <name evidence="11" type="ORF">G6M90_00g077810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987068.1">
        <property type="nucleotide sequence ID" value="XM_066131077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0L9"/>
    <dbReference type="GeneID" id="26241357"/>
    <dbReference type="KEGG" id="mbrn:26241357"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21940" checksum="B341AE187A233EB5" modified="2021-02-10" version="1">MSGYSLAPFILRRPWLANMVMPAANWYANAAGYKKLGLRYATHPQHIPTPDSQQARTFWPPRSRSRPTDMSQQQIGASKRTAFRTNGLQWATADPQTAAATRRRYDDLVEEERESTQIALRRLSSKESYDRIYRIRRSVQCSYQHKLLPKDQWTKPEEDTPYLRDIIAQVETELAEKDALDSMTVAKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0Y0</accession>
    <name>A0A7D5Z0Y0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g003810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985646.1">
        <property type="nucleotide sequence ID" value="XM_066129557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0Y0"/>
    <dbReference type="GeneID" id="26245066"/>
    <dbReference type="KEGG" id="mbrn:26245066"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="338" mass="38093" checksum="43CD5BB6BA9281D8" modified="2021-02-10" version="1">MADEPSAIDRHGDLRLKVGSPQQAGDTLCQSVEFLVCSRALARASPVFDRMLYGAFAEASHNQEGSEGWTVELKEDKPAAMEVFLNVAHANFARVPHVLSVDRLYDVAVLTHYYDATRQLAPWVGSWMASIVEMTRDANVIMPKMLWISWEFGRKEDFIAVARRMLMEAKTPWAMEPDSGDDAVQTPPHIVERINTLRVQTIQELLDIVKDLVAKLMVVDEEPRWCRHATYLGHHRCESMLLGSITFCLARAGLWPLPEAVDVELSLFDLYRVLATLVIHDIGKTNEKPAVDHQDCNPSPQLLNQVQMVMGQIPSPLTDFHVKHLEEQAQRLKHGAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1N4</accession>
    <name>A0A7D5Z1N4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mic10</name>
        <name evidence="10" type="ORF">G6M90_00g018330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548706.1">
        <property type="nucleotide sequence ID" value="XM_014693220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1N4"/>
    <dbReference type="GeneID" id="26238150"/>
    <dbReference type="KEGG" id="mbrn:26238150"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="92" mass="9945" checksum="5129C117781DA59F" modified="2021-02-10" version="1">MPESAPAAAPASAISRPVSEALLNEKWDRCLSNLLVKSTLGLGFGVVFSVLLFRRRAWPAFVGAGFGAGRAYEECNINLKLAARDLKKQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Z3</accession>
    <name>A0A7D5Z1Z3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g083710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543588.1">
        <property type="nucleotide sequence ID" value="XM_014688102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Z3"/>
    <dbReference type="GeneID" id="26243765"/>
    <dbReference type="KEGG" id="mbrn:26243765"/>
    <dbReference type="OrthoDB" id="4937228at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028925467" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22573" checksum="1AA74CA528099AD0" modified="2021-02-10" version="1">MLALSLLLSAVAVNAILGGEVAGVLISDKEFFCADECAYKGVFFEQGGKWCTRNDTTAIVNSEGLAHPRYPHACAGSRVPEGWQERALKNGEEPKQCYVYEPTEPFDYFCEGDKSAGGNAKNVNVQWSELEKKLAPASSTNSASREGEQGATEKSKPASPEKLKQCNDLREKNFWECWNKFKDDFQKCVDDAQQVREDCRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Z4</accession>
    <name>A0A7D5Z1Z4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KP4 killer toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">M2A_1</name>
        <name evidence="3" type="ORF">G6M90_00g056860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544272.1">
        <property type="nucleotide sequence ID" value="XM_014688786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Z4"/>
    <dbReference type="GeneID" id="26242684"/>
    <dbReference type="KEGG" id="mbrn:26242684"/>
    <dbReference type="OrthoDB" id="4177994at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.10">
        <property type="entry name" value="Killer Toxin P4, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015131">
        <property type="entry name" value="Killer_tox_Kp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011329">
        <property type="entry name" value="Killer_tox_Kp4/SMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09044">
        <property type="entry name" value="Kp4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028876593" evidence="1">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Killer toxin Kp4" evidence="2">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="134" mass="13613" checksum="E32796C8087149AC" modified="2021-02-10" version="1">MVSLSIVATFVASAAALGINCRGSGGCTFNDAKLSDVLTQVKQIQAQGNGNHHYNMGVQLACAQGQYSSICAFYQNGASGTANDAAGQLQGLVDHKCSQCGSIPTQPGNDVSKGELTVNIVSAPCCKGNCACPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3D8</accession>
    <name>A0A7D5Z3D8_9HYPO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g021080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38449" checksum="28490F9AF7800232" modified="2021-02-10" version="1">MWQCVYSAGIAFYLVGNYPEWREGIFSVVRDVSSLFQWLLSRGAPGISASTCKRVIQHDSASIWTPTRPSAIKSRTKALMATGTITTEACDTYHGHQIPLHLPDMAGMVAAMNDPFIVMTDCSSLGFARVVWDFIALKISQYRNDGNGHCFFVFHPDNAWMGAFVRLERAEGQLPPEFIGVAHDLFVLCRWMLCVRVALVQAMGDAGKGIRFHILIPSSEPLVIPRPLSFIDALYPLTLEGPTRRGQTLVWLRVVPESAGVLKDIGAVPSPCPVGAERKACAAVCIMWIVASPALVMVCKLVCSPRTPFYMALSLTTVFHGLALVATLWFKREVRDYYLQEDVPAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3F7</accession>
    <name>A0A7D5Z3F7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANK1_0</name>
        <name evidence="4" type="ORF">G6M90_00g031520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543090.1">
        <property type="nucleotide sequence ID" value="XM_014687604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3F7"/>
    <dbReference type="GeneID" id="26243891"/>
    <dbReference type="KEGG" id="mbrn:26243891"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
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    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI67706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="318" mass="34554" checksum="3409EA60EF6D4CE6" modified="2021-02-10" version="1">MGIMSNGHGSPSQSRKLEEQAQKLVEASSAGDIPHLEALLEAVQDLNRDPAHLPTDGFLLQTAARQGQAECIRFLFERLPGCVARPNKRWDPVLPDGYSYTDIPDKWHVYKDGVIHEAIGGKDPVGLFRVFFNYGMNPNVGLGYAGSPLAQAVSSNQLPLTEYLLARGADPNGTYMSSRLLGVAARQPTDDVLRALVAHGALVLGSQALQQAAHYWRARTAETLLRHGADINEVFAREEYDDSMQLVRVPLGCALHFAVEGGMRGGGPAEQSDFVRFLLGRGARTDLVNDRGETPVQMAERLGKTSIIDVIQSRGVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3X9</accession>
    <name>A0A7D5Z3X9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain transcription factor tcpZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tcpZ</name>
        <name evidence="7" type="ORF">G6M90_00g000370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543029.1">
        <property type="nucleotide sequence ID" value="XM_014687543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3X9"/>
    <dbReference type="GeneID" id="26244402"/>
    <dbReference type="KEGG" id="mbrn:26244402"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR RGLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="357" mass="38940" checksum="F8A9E4FE5D70A4E9" modified="2021-02-10" version="1">MFTSDSQQPDSPALDGRLKKLRSACDACHAAKVRCSGEATCSRCLRDNVPCHYSYRAHQGKPKGSLNKKTIERIKAARAAAESEAQPGHITSQGGSACPRPGDDVLDFIEMPPSTCHNSPDPVTATPSSHFPLMGETFPAFGADDLDSFLNAYQTPPQSRSSKPVGDIPVASDMDPGCIFVGTPSSSSREYTDAAASCCCVRTMTRQINHVHAAATDRSAAALDHVLHHTRETATCVSRFLQCHTCGVEVQVYVLAAVVLSLLLEIMHPLTDSSLETCRPRAQIRVGNYDMSGQLGDVLEKVIVRSMITKLRQVVDKFEMRVEFLRSETAQVDFLKSEARRLKRGFERIGEETATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3Y1</accession>
    <name>A0A7D5Z3Y1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal membrane protein PMP27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PEX11</name>
        <name evidence="5" type="ORF">G6M90_00g036860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986612.1">
        <property type="nucleotide sequence ID" value="XM_066130189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3Y1"/>
    <dbReference type="GeneID" id="90967622"/>
    <dbReference type="KEGG" id="mbrn:90967622"/>
    <dbReference type="OrthoDB" id="411017at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI68587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="241" mass="26889" checksum="2E2DDBB99DE569C5" modified="2021-02-10" version="1">MVVNTLVYHPSVKHYLSFVATTVGRDKLLRTIQYFARFYAWYLLRTNATKAQIAPWDVTKKQFGLTRKILRVGKNVEHLKAAVETADNPKPLDAFLRYAGIGRQIGYAGYLTFDSAALPDAAGIKKWDKAKTVQAYGYRFWAMGLVFSISAQLYTLYQLKQREAKIDRKDGEGVINSKHIARERAASQLQLISDLCDLTVPSSALGWAGFDDGFVGLAGTLSSLIGVYNQWKKVTAKPASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4K8</accession>
    <name>A0A7D5Z4K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage-responsive protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g089940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541653.1">
        <property type="nucleotide sequence ID" value="XM_014686167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4K8"/>
    <dbReference type="GeneID" id="26245516"/>
    <dbReference type="KEGG" id="mbrn:26245516"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12665" checksum="942903A70493B57E" modified="2021-02-10" version="1">MDFVKKVADGIGGSGNNQSGRENENNQGSNGNNSDAGAKLMDSFNSMAGGGKQGEANEDGLDKAVDFVQEKVLGEGDQSNESAAEQAKDEAISDFIRDKYKETTGKDFFIADKDKKYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4T4</accession>
    <name>A0A7D5Z4T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g091530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987260.1">
        <property type="nucleotide sequence ID" value="XM_066131401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4T4"/>
    <dbReference type="GeneID" id="26245269"/>
    <dbReference type="KEGG" id="mbrn:26245269"/>
    <dbReference type="OrthoDB" id="4961339at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028959038" evidence="2">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="242" mass="24362" checksum="A8B3D9A696072992" modified="2021-02-10" version="1">MRLTNVVVLGAALPPLASAANFVRGNRVSFNTFKYDIDKCTDEKPCSLYLPKSAPHAGLQIRPRVTDCLERAFSLINGGTIENQAGTEFIARIQNVPSGTYIFQATGGEDGKTAITTQFTYNTNLATIGTGTGTVTPPSPTTSSPGTSLETTSSPPGPTAASSDSGSTGTSAGPVTGSLTGTSTAGRTGTAIISSTGSLTGSSRSLKSSGGNAGNGGAVVDENCNGAIDNNDCAELGGSCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5N3</accession>
    <name>A0A7D5Z5N3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar basic amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">VBA2</name>
        <name evidence="8" type="ORF">G6M90_00g106270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987986.1">
        <property type="nucleotide sequence ID" value="XM_066131702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5N3"/>
    <dbReference type="GeneID" id="26247614"/>
    <dbReference type="KEGG" id="mbrn:26247614"/>
    <dbReference type="OrthoDB" id="4939452at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="548" mass="59248" checksum="921090883A638809" modified="2021-02-10" version="1">MAVRFQHASRPQANTTRFYLSIAAILVSNFMTAVDASLSSSAHVAVASHFNRTNVSTWPVTAFLVCSITVQPLYASLSDCIGRKAIYLSCAALFLLGIGLAAAAPSWTCLILARCVCGLASSGLTIMGSVVLTDLVGVKKRGYYQSMNYVNFGSASALGSVSGGTIVDRFGWSWLYKIQLPFALVTLVMVYFFIPWTIEASEDTSSRDDTTEGRRLLSLFDWTGALVLVISLLLLVFVLGTAGNVLPWTNPFVLLALFLFPCTVYALVRVEANAQKPVLPLVLVQFPFRNIMINAFFLSIINYIVMYNVTFFFQAVLLETPGQASTHLVAPSIAFTIVSAISGATIARLETPKPTLRISQVMLLCGAAGLMVMATILPRTETPGALYNLCLAMPILGVGMMAPSALLLLLGMSDRNNHATLNGGFIMMRSLGGFTATSISTTIVQNVFQQTMRPFMTSEEIKKKIDSVRLNMDNLQTLEEPLRAQVVNAYRTGFIVLFGLVITLSVLIIFGFIGVSDGQVVQEAPDTAEPGSVTEMEDLMGDTDDSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5V1</accession>
    <name>A0A7D5Z5V1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">gch-1_1</name>
        <name evidence="14" type="ORF">G6M90_00g055420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544137.1">
        <property type="nucleotide sequence ID" value="XM_014688651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5V1"/>
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        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:GTP cyclohydrolase I activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GTP-CH-I_C/QueF"/>
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    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
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    <dbReference type="InterPro" id="IPR018234">
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    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="167"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI69726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="349" mass="38384" checksum="5860AAF37ACE9F55" modified="2021-02-10" version="1">MPQSEPTDGRDTPISSASAGGEGKAKRRKSKNGNGGGGSGSGNSSGKRERGDQDDEAMAKLANGPHGDGLRRSSISKPGRDRRDEPEPRTKRQKREKRDKSEKRRQTAADNDEASSSGSKRDASRSRSLARLESPVIDFDGLSRPSVGARDRLEEDPEAAAARLDRIKGAVRTILECVGENADREGLLATPERYAKAMLYFTRGYEQNVLDIVNGAIFQEGHSEMVIVKDVDVYSVCEHHLVPFTGKMHIGYIPNNAVIGISKLPRIAEMFARRLQIQERLTKEVANAIFEVLRPQGVAVVMESSHLCMVMRGVQKTSSTTVTSCMLGCFERRDKTRNEFLSLINVNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z633</accession>
    <name>A0A7D5Z633_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase sdnE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdnE_1</name>
        <name evidence="11" type="ORF">G6M90_00g065170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z633"/>
    <dbReference type="GeneID" id="26247066"/>
    <dbReference type="KEGG" id="mbrn:26247066"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="525" mass="59576" checksum="C5F1F89D84448BC5" modified="2021-02-10" version="1">MLSDVTRSLWLGPYTILLLIPLYGLLLAVFRLYFSPLSRFPGPRIAAATWWYQFYHDVVRRGRYIWVVRDMHARYGPIVRINPSELHICESQFYNTLYVSGGIHRKRDKWSWDSVGAGGVRDSALSTVAHDLHRVRRSAIAQFFSAQNVDKLQPVIQSKADLLVRRLAERRGRRTVVTNLNHAFSALTNDVIMEYCFARSYDRLAAPDFDPSYKHASHRGVRLAQIAKHIRLLGWLVTAMLALPESILVRCGPAFEMFLTERKRLHRQIEELTLESKAVGQDASHLTVFRELLGSKLPPEEKTPARLSAEAQVLVSAGSETTAKALTVACFKLLTHPAVLARLRDELETALPSFGLEPGLRLDQVQRLPYLTGVVKESLRLSYGVVGRLQRIWPDEEIVFREWIIPRGTPVSMTSYDVHHDEAVFPDSFAFRPERWADDPGLDRYLVSFGKGSRHCVGMNLAMAELYLTLAKVFRLFGSGRVRRPGDIGQLVLFETDESDIRMTGEVLVPFVKPDSRGVRVVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6B4</accession>
    <name>A0A7D5Z6B4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g058690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544443.1">
        <property type="nucleotide sequence ID" value="XM_014688957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6B4"/>
    <dbReference type="GeneID" id="26242855"/>
    <dbReference type="KEGG" id="mbrn:26242855"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="229" mass="26186" checksum="3845DDD7C95921A9" modified="2021-02-10" version="1">MDASALLTSQGWRGKGHSLHKTDNSIGLAKPLLLNRKDNRKGIGTTSHFTSDQWWLNAFDEQLKGLETSKEGQVTQTVKTGKLNAIEKGSLGKYSLYTSFVRGGFLEATLPTSESSSEDESGGTPETSEPEAKTDKRARKEEKRRLKEEKAARRKEKEEKRLKKEAKRQKEEDPLAEARGERAARKEEKRRLKEDKAHQKAERRRTKEERRARKEAKRREHSQVQVACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6H9</accession>
    <name>A0A7D5Z6H9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g095760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546754.1">
        <property type="nucleotide sequence ID" value="XM_014691268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6H9"/>
    <dbReference type="GeneID" id="26241177"/>
    <dbReference type="KEGG" id="mbrn:26241177"/>
    <dbReference type="OrthoDB" id="5327145at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="443" mass="48574" checksum="B0BA4AC6C332BB92" modified="2021-02-10" version="1">MLAAHRDQENLVHSHHQGPTKQQPKTPGARYPKTPGNFGRGDENAPMAFADKTAFGGGAKLGGKDRLMTGKMTGQRQTMLTPMDNRTRAPLGNKTTNAKARTGQTTGVKDIVREIEKTQTRQSSGQKTKQKPVNPQPIKLNIEHDKHDDADGNEIPEPEYAPPRPTPLPYESDVLPPGGLTFNGLKKGNLLKGYYQHFHNPIDENGVSLMEKKFNKEMETVLQKAEERNAQEVNAIGWSPEDIEDNQIPTTVSSDRVKPATDLSSRRARTKSSQLQPASISARRAASMLAVRSDKQNGNVPRPASSSSTTRRPLSGIISVTRPARPVITKPSSSGNSTGEAASRTTLGYNKGRSASSMVHSHGNSQSIRQRQQPKPTVPQDPDSQMTITPARICRATSCNTESSRPQFMSIFDDGDEGDLPPLQRPFLPSDDEEDEFEFKLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6T8</accession>
    <name>A0A7D5Z6T8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife protein DSP-PTPase phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g111340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987944.1">
        <property type="nucleotide sequence ID" value="XM_066131829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6T8"/>
    <dbReference type="GeneID" id="26243117"/>
    <dbReference type="KEGG" id="mbrn:26243117"/>
    <dbReference type="OrthoDB" id="4941550at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife protein DSP-PTPase phosphatase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="302" mass="33204" checksum="C8F2E9ACBB1E063F" modified="2021-02-10" version="1">MRTISLPGTDINKTSNMFLKSLVTLLGAAVAVQSLPAGESANELEKIASNAGFQRFEYVTEHVRDGDGLSRSSAPNYVWKDSDQNLTADSIKFLQAGNNNVGIAYTPLPIVDFGTPTLEDFQKGYEGFKKHRPGTLVWCGFGHGRTGTMISALQIYIEHEKPSPQLLTRQDYDNNHVEEDAEEAAKPKPKPQPGSAEYNTQLLKEKCDASGNSPACMKAGNRCAARFAASEKIENFLNCVEKVQVCLDYYRQEECEEFAAQCQAELGTLSSNFYSLAECTCKKQGKVEGEALKFCVSEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z884</accession>
    <name>A0A7D5Z884_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">REV3</name>
        <name evidence="29" type="ORF">G6M90_00g089310</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20 22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms DNA polymerase zeta with REV7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541594.1">
        <property type="nucleotide sequence ID" value="XM_014686108.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26245457"/>
    <dbReference type="KEGG" id="mbrn:26245457"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05534">
        <property type="entry name" value="POLBc_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000007">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000018">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000002">
        <property type="entry name" value="DNA polymerase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000024">
        <property type="entry name" value="DNA polymerase zeta catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="15 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="28">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="854"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="1105"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="1593"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="504"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="646"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="QLI71807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1698" mass="192428" checksum="345B2BDF7610F374" modified="2021-02-10" version="1">MNLFRVRLNCIDHYQAIPTRYDPQLRNDVRASQVVKGPKVPVVRIFGSTETGQKVCAHVHGAFPYLYVEYDGDLAPDEVGAYIYRLHLSIDHALAVSYRRDQYEEDAKFVARITLVKGIPFYGFHVGYRFFLKIYMFNPIVMTRLADLLQQGVIMKRKFQPYEAHLQYLLQFMVDYNLYGCGYLESSKTAFRSPIPAYDAGSNSSHLWHSLSVLPQHITDDSSLPRVSHCSIEVDICVQHIVNRQAVKERQLHHDFIERNSPIPANLKLVFSLAGLWRDETKRRQRQMPRGKQGLSPFPPDVLVSMSADARQSRPQGWIHEEEHVQQITELVNAELAGFDDQHPKFEDFVEPADPDGEVHTALQSVEDLFPSNLIPALGLSSNMTQSTGEPPASSIEVDEKKILEELNRGDEFFPDDSDEERLREMTRAEHSAENDMGQEAAAAVTEIISANRGSSSTRIKPLQPSSHLMPGVCLSVLSTGSLPTVPISQELLDAAEDEGLVGRVPKSKALRPQKLMARKRQGPVASSTGSPQKRQKSYKAAPPSSVQQIVADSSSSPKPSGFRSVNQRHSTFSAPRDGCSPSSSDPLATSNRTLNYAITKEQSGKSSKVRFGQRSQISPIKHNDGSKLTKTMSCHQSVDDLLGKTGNSQFDVPTPKFSSNLSEHDNERTKIQRAVAKVVDNRFMIYSYMPPTASQCSAVKDPELPDVIYQDAFYSRESDVPERNREYAGREYRLESNTLPFLPNFDVDGVSRASYGIKTDNYQVQQALEQEQALQRRHCNWQSWEYAQLPPSHQEVVHWLNTRKRQKEADKKAPRHVFPSSRAWLSQIDGPTQKNKHGFKYTQKGKSTSVEHEVQYMSTMSLEIHVNTRGRYVPNPEEDEVQCIFWACKSDEVVGISQNSPGAIHTGIVVLSQDGKESQAMRKSTGSDIIEESSELDLIVRMVEIVRTYDPDILTGYEVHSSSWGYLIERARCKYDYNLCDEFSRMKSDSHGRFGKQSDRWGFNTTSTIRVTGRHMINIWRAMRGELNLLQYTLENVAWHLLHRRVPHYSWKTLTSWYKSGKSNDLGRVVRYYQTRTLMDIQILETNDLIPRTSEQARLLGVDFFSVFSRGSQFKVESIMFRIAKPENFILVSPSRKQVGSQNALECLPLVMEPQSAFYSSPLLVLDFQSLYPSVMIAYNYCYSTFLGRISNWRGVNKMGFTEYKRQEGLLALLKDYINIAPNGMMYVKSEIRKSLLAKMLTEILETRVMVKSGMKSDKDDKVLQQLLNNRQLALKLLANVTYGYTSASFSGRMPCSEIADSIVQTGRETLERATAYIHSVERWGAEVVYGDTDSLFVYLKGRTRDQAFEIGNEIAKAITEINPQPVKLKFEKVYHPCVLLAKKRYVGYKYESKDQVTPEFDAKGIETVRRDGTPAEQKIEEKALKLLFETADLSQIKEYFQKQCDKILRGAVSVQDFCFAREVRLGTYSDKGPPPAGALISTKKMLEDARAEPQYGERVPYVVITGAPGARLIDRSVAPEDLLANPHWQLDAEYYISKNLIPPLERIFNLVGANVRQWYDEMPKVQRIRRAPNDPGAKKMTLESYMRSTHCLVCGAKFAQEGQTLCPACRDNTPASLFMLQTRLATEERGYQDVLSICQTCSGLSPLEDVRCDSKDCPVFWTRTKQRTKVAGMRATVGPVIRALAEGKMERSALEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8N0</accession>
    <name>A0A7D5Z8N0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Right handed beta helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g065990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540174.1">
        <property type="nucleotide sequence ID" value="XM_014684688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8N0"/>
    <dbReference type="GeneID" id="26246983"/>
    <dbReference type="KEGG" id="mbrn:26246983"/>
    <dbReference type="OrthoDB" id="3432466at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028883364" description="Right handed beta helix domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="2">
        <location>
            <begin position="229"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="499" mass="52397" checksum="8E4D3D02EF29D2A9" modified="2021-02-10" version="1">MQPTSLRTASAAALLTLLTLGSAQGKQYYVDCSRPDAGEGSQHKPWNSLQKVNSPTFAPGDVIAFKAGTTCTGTLSPKGVGTADAAIRITKYTTAGAADNNPNPIINGTGAAGAAVTLTNQDHWQISNLTVTNPASGLAARQGIHVTASDGKAHTGITIEHNTVHHVAGQTNKRTHSKDFILSCGILVDTSGAGSRYDGVLVQHNAVSDCGGGGIKVRVGAADNLGHKARVTRNTIRACGGDGIIISYSDSPLMDYNVASDLGTGAYPFTGGNFAGMWVLGDHNPTISHNVVYGSTMSDIDSEAFDCDWGNTGNCTVEYNYSRANAGGAFLNCDGCGPPDAPPGGADQIVRYNIFENDCRMYSNGRRPTLYFYQNVMYCPDEERGFDIAVAHNAYFTNNIFVGNGKASLPARSDIRWRWNVFYRVPHPTDNGIEADPGFVDPGSGGNDLASVGGYKLRRGSPALGNGAVIPDSGGVDFFGNPVSFTQKPNRGAYNGPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8U9</accession>
    <name>A0A7D5Z8U9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g085690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541128.1">
        <property type="nucleotide sequence ID" value="XM_014685642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8U9"/>
    <dbReference type="GeneID" id="26246117"/>
    <dbReference type="KEGG" id="mbrn:26246117"/>
    <dbReference type="OrthoDB" id="5138259at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697:SF1">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39697">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="210" mass="23505" checksum="801651F1A697EC53" modified="2021-02-10" version="1">MSGLTNACDAESTTTSSATGNGVPTPITDTASLADHSAMDGWLDKLSYDQPQASGDGQGSSTALFGSLRVTRTSHPMADSTFLIIDKSQNRALVCHNGHLHLEDIDAVNFDKPISGHWQWLCTERNGFKGFQNVAELGFLGHDLWWDFYAKSHRHEGWESFTVNRREGNYYWIQALKWWTHWQLSARADGSGLFAERDGGTLWEFVELHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z916</accession>
    <name>A0A7D5Z916_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Extracellular metalloprotease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MEP1</name>
        <name evidence="12" type="ORF">G6M90_00g092980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541942.1">
        <property type="nucleotide sequence ID" value="XM_014686456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z916"/>
    <dbReference type="GeneID" id="26245410"/>
    <dbReference type="KEGG" id="mbrn:26245410"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028967499" evidence="10">
        <location>
            <begin position="19"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI71906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="267" mass="30572" checksum="E5FBE351E631EB73" modified="2021-02-10" version="1">MSLLTFLVAMLMANAVNASAIHVRQEAAPPCQEQVPSEEFVEISRKLRLEASNSSLTRRQQENFNIQVYAHVVYDHTRGNRGYVQEHLIASQIQIMNQHYRNVGISFTLADVDKTRHPRWAYGYDEFAMKENLRKGGYADLNMYFVASIPGGAAGGSRTYGICYYPIPRQLQFVEFIRDGCTVIAQSVPGVDGWVKQNHIATHEVGHYLGLYHTFEWGNWGERICSPGDDVGDTYPQEQPSHYNTRPMVWACRGWQRSNMYNFMDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9E4</accession>
    <name>A0A7D5Z9E4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">svkA_1</name>
        <name evidence="20" type="ORF">G6M90_00g092450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541889.1">
        <property type="nucleotide sequence ID" value="XM_014686403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9E4"/>
    <dbReference type="GeneID" id="26245357"/>
    <dbReference type="KEGG" id="mbrn:26245357"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="336"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="491"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI72266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="678" mass="74948" checksum="144A0707C74CE24C" modified="2021-02-10" version="1">MAERFRDDEANEALDPELLYSKEYCIGGGSFGKVYKGVDKRTGQAVAIKIIDIENAEDEVEDIIQEIAILSELQSPYVTKYYGSYAKGAELWIVMEFCAGGSCADLMKPGLIEEDYIAIMLRELLLGLDYLHSDKKLHRDIKAANVLLGAGGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITALELANGEPPYADIHPMKVLFLIPKNPAPRLEGNFTKAFKDFVELCLQRDPKDRPTARDLLRHPFIRKAKKTTYLTELIERHSRWAVTHKGDDEEHWDAQEGAAPTERETVDEDMWDFGTVRLVGDRGGVVRRPGLHVVDGSTTNARSSRPLDNSNDQGEKRRDASPLKTKDIALQPSDTVKAGNAATSRQSSPQRKPVPADVTTASPTRLPPSASPLKTLTRDTPETPSSHHPSQRPLPPAPTSQSPEYDQELQYQLQRDIGLLNLNMSPSPVSLSHHSQYPTDRALPRVQQDSPTRQPGSRVSSMTIPEIPPYRGPSASRVPSQQVAQSPRPPTAGNPTPPPNPHSPAQSDVSIQPSSFPSPAPANPNGELDALNDVIFPALEEALKRRQIRLQQMYRPAQNGSPVSANQQRAEAAHEKIRKLVYKLAYVCKEIDQCDKAEPVGMGREVGNFLEGLLEEILVRVEPLDEEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA97</accession>
    <name>A0A7D5ZA97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Highly reducing polyketide synthase gloL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gloL_2</name>
        <name evidence="3" type="ORF">G6M90_00g093640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540733.2">
        <property type="nucleotide sequence ID" value="XM_014685247.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZA97"/>
    <dbReference type="GeneID" id="26246346"/>
    <dbReference type="KEGG" id="mbrn:26246346"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="2">
        <location>
            <begin position="18"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="1">
        <location>
            <begin position="153"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="326" mass="35681" checksum="9D4873D57BE17CC3" modified="2021-02-10" version="1">MDAKCHCQPAAILCWAYDSILWNGSRLSLEFRNREFERHELLGSEVPGGSDTDGNWRNLLLDDTVIVPGGAFLAMVMEAVSQTTGGSLSPGTGLEMRNSPITNMSSSETLWDFKLTIYREGVPVLHATGTIAIHESAAAEAIEPRIRLSEAELESSAKQIWYQRFGKGGLNYGPLFQSVNEIWVLRSSADKVVLGMVRLEQKSAVDGSAPARYLFHPITLEVMVQAGILATESRLQTYTASTNQGARGLARYPTLRVVWKPDVQGPELLREADLTKYLNHFLAEAHSPVGKDDGLIKLGAAISLISHRNTRLSIILELAAVLALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAT4</accession>
    <name>A0A7D5ZAT4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KIN7D</name>
        <name evidence="16" type="ORF">G6M90_00g100060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546343.2">
        <property type="nucleotide sequence ID" value="XM_014690857.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAT4"/>
    <dbReference type="GeneID" id="26240766"/>
    <dbReference type="KEGG" id="mbrn:26240766"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 12 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="208"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="79"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="845"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="907"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="854"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="288"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI72828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="956" mass="102691" checksum="B019E4AD38AB2328" modified="2021-02-10" version="1">MALPALPVHKTRKSTENIPSHAPVKSAPSTPRSGLRAPSSILTPPTPVPTTTLPFSKSLASVNAIGAVNAAGKTLRKTVSISSFPHPPRGESRSSSLPPSPLASEKTRSRRSKTPKELSHLTYSPSTPSLLNGSGEGKSISNARMSDGLISISSPPQSRSSSAQDSYSTSATTYDEPGEGSAVKVDAGAPVVGSASDKRSSKSDGKGNVVVSVRVRPDNAPGQSNPEGEWMVDGRKSLIAYKGKEGGDYIYDNVFTTHDNNARVYDHIAKRLVRRVMEGYHGTVFAYGMTGTGKTFSMQGTASSPGVIPLAITDIFSYIRETPSREFLLRVSYLEIYNERIHDLLSMPTGSGVGGAPQQDEIKLREDSKRGVYATPLKEEIVQSPTQLLRVIARGDQARRTASTQFNARSSRSHAVVQIVVESRERTPGAAAGGNEAKRSAILPGGVRVSTLSLIDLAGSEKAAESKERRQEGAHINKSLLTLGTVISKLSEWKDKESKSSDKEGKHLPYRDSKLTRLLQGALSGNSLVSILCTIQIGAAGSTAAANSHTTETINTLKFASRAKNSIVSHAKRAEEALGAGGDGGARVLLERYRMEIVELRKQLDSQKGKRSSKDSEADKDKEKDEEAEKVREMEAVERHEEQMLEMQLARTALKERIDHLNRLILSSKSIGVNSNGSLSSLGQYARFSQLSLTGSIRSSVATSIGSKPLLERTASMTSASSTIGRRSSGGQRLSGECEREAIDAEDDSVGEYGDGTASLTAQNRALQADLVDKNRYIATLEKRLLQARRASSSRTSVGFSAPSKNIMVGEDHSVAAALKEKDAEIADLRARLDDKDRMLAALRSAARSRDTADASADARPTPVTDQAKTTMPSSPTNNQFHRRRTKSVDEMNRMLEEMIQDRVETGQIIRGSRGSVRLPGGQKLDSLAEPPHTLEPLRQSPVPTASPAVSAIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBQ1</accession>
    <name>A0A7D5ZBQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g089610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987415.1">
        <property type="nucleotide sequence ID" value="XM_066131356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBQ1"/>
    <dbReference type="GeneID" id="26245486"/>
    <dbReference type="KEGG" id="mbrn:26245486"/>
    <dbReference type="OrthoDB" id="5400196at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="518" mass="57067" checksum="E1CAD1F1023658C9" modified="2021-02-10" version="1">MVYPEDRNEEATSDEETEAESQTEEAPETIEIKLPQNFRRNAILVLLLQLAVFIFLVVARCIPISIRKPGYGVLEAKCQFLYSLGVGIASVLVSMPAATTLRMVYLKKVQARESSKPMLRQATTVVGLSSLRNMLRYWYISGTFLIVSLISAGIILAVTPSLFPFKYPGLTYFFPEHVIQLDDYAVDRCFTDGGAGSVDGLRVLPFLAQSIAFTLDDPDLAYSMGGVPVNKSAMGVPFEVLYEAFVGAFGLHTLGEPVGFWSELESVSICLPILETKPVSCFKTGSLLLSGRNLTVSSNGCVASTMFYSVDPSSQGATVAGTHATEFSDFAGFAGQTQNDTFALTCSIDLRPSIAIRRLKLARYSRKYLDKINYNFQFAVTRDRFNDLPCQGNMSLDWMSTSTALAVGASAPWQLLRERSHLDGHLDTLLATTVNWNDTVSRVSKLEAGLWVTVAIGIGMYWASGQGNDGEKVVSMGEYMLEGLRIGPYKWWGLVYTFPLLFSILVLAVLLWQTRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZC94</accession>
    <name>A0A7D5ZC94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g110330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543826.1">
        <property type="nucleotide sequence ID" value="XM_014688340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243213"/>
    <dbReference type="KEGG" id="mbrn:26243213"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="346"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1284" mass="143749" checksum="B4206FE01B9F4777" modified="2021-02-10" version="1">MQPLNPFLAAFFKSPVAAQCTPVHHHILLVPLTDELLTSREIDSGAAASEVIASEEFLGSHVLRIPSPSVSSGGKDGVHNLRDVRGKAKQFSTLNGRSVVIKDSVVYSNKGFKTFAQAQILNDAIWYPDVFEPRQWLLYFISKPLVGAWEEVKILPAVLGNGVNKKMTLDTKKVNGSDTAEGTVPKKKDIRSFHELLNNFPMIARQMQPGLEKLFLEFTTVFEKPLPPPPSASRIPDPLPDGPITAAMRRARSNSFSIRNGKAINRDSLPVTEDFYAEDDEDVMRASLETAVTAAIDLFQSVDKQQLSLLGATTDLTGPLVEKLIERYVTENINHLIFPKLSAIKRPEDLELEAKIRQMEYIDISQLGIAIDGGSRAKHDLLIQLGPAIEEFKKIANAMSPGEMMDALLSTTKAASQLTDTSRTQMANGKEDPVYEKAIMTVNADTLVSLLLYVVIRSQVRNLQARLVYIRNFIFIDDVDSGEMGYALSTFEAVLAYLALDSAGLRRASRRNKALWDAAKRTDLTELKAIMEPNMSAVVDGDDDFELDGDPDEQARPIRRPSFTWSLQDSSSRRSSLALTPSDRFSRGSGLGHVFPFQSNGNCEEGDFSLVKRVKRVAMDTRSLSSGSEISFHSRTGSIGTLGSAIEGDVSVERLAQTSNSFGESVLMIAVQSENPASLRYLLSLSGYYSLEVILQDMNNEGTTLLSAAIQLGHKDLINMLLERIDICTEDQRVQYLSEQDIWGRSVGHYLFHAPSLIARIGKLIPWRQRDKNGQTPLFALCRSYDNENYYDMVEAGLRVARETQNDGQALHLDDHVDAKGNTLLHIINDTRLAMRILHYCDIDVNATNEKRFTALMVASKYGRYDMVRCLFADPRVDIAAREMRGLTAVELAKDDDVRNKIDDLALFSMPAGRDGRITGVVRAFFVEDGSVRLVLKSAAPTDHDSYTVTTTRRSLAEFEQLAHLLAEEQPASWIPSMSDTRSPFQIPVKPSRAILRDVQAKTDWFLRIMLSHPTLATHEMLWEFFLVPELQLEAMEQRTKLKVEARIERIKEEYEPIRDMREVEQFVNHAREMVRSVSYSTKSVTRRANGVGLAISDLYDSMVLLHRAVSSIKFLPQSHISALEAYVRAMAPTQASPQAMLHNTLMAIQSTVQALLSSLARPTTLISQITAAKRDADRNDSSAGRSSRWVLGLLDETRQRIQDGREKRAKKYREEAEYLSRELRYTQQTVAGELAGWQDMHEKMGRRAIREFARAMVVQERTRLDGMVRALRKVGTQRSNVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPU4</accession>
    <name>A0A7D5UPU4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Stx18</name>
        <name evidence="10" type="ORF">G6M90_00g023180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548237.1">
        <property type="nucleotide sequence ID" value="XM_014692751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPU4"/>
    <dbReference type="GeneID" id="26237681"/>
    <dbReference type="KEGG" id="mbrn:26237681"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI63611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="359" mass="39759" checksum="921FAE9F4BA3D7D8" modified="2021-02-10" version="1">MAFSAASHLPSTDLTDDFNHALQKHNAAPTSGKAALDVDVLEGFVKEAYRINSHITSLHKELRDVRQAYLSTAQPRRTPGRTAHGPPQVLTDREREDVDVNAKQMIRELNASIRGLEDAEQLRRETESALIRKKYASGFSALSSWASGGSISSRSPEHAAAEAQAQQTDMHRDGILWYLRQRLELCCRTQQDMMETRLTREVEKSRGMLSPPVGDFAPFPPVSKQAFMAAAISEDPALAGETATQASALTQGLTEEQLQMFEEGNQDMMQHYESTLDKVRTAEKSLVEISELQSLLVNNLEIQSEHIEQLVTNSLSTAENIGGGNKQLEKATKRPSTARYTFFAASGLCAFLVLWDLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPW6</accession>
    <name>A0A7D5UPW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">T184A</name>
        <name evidence="7" type="ORF">G6M90_00g006270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549880.1">
        <property type="nucleotide sequence ID" value="XM_014694394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPW6"/>
    <dbReference type="GeneID" id="26239324"/>
    <dbReference type="KEGG" id="mbrn:26239324"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="84"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
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            <begin position="186"/>
            <end position="208"/>
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        <location>
            <begin position="228"/>
            <end position="248"/>
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        <location>
            <begin position="441"/>
            <end position="573"/>
        </location>
    </feature>
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        <location>
            <begin position="442"/>
            <end position="458"/>
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        <location>
            <begin position="468"/>
            <end position="480"/>
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        <location>
            <begin position="491"/>
            <end position="501"/>
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        <location>
            <begin position="524"/>
            <end position="534"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="573" mass="63324" checksum="901118E81B494604" modified="2021-02-10" version="1">MSVTSASIASDGGTGAKFTYATTVIAGVASFAATLLSVVSIWLQTKNYRKPLLQRYVVRILLMVPIYSIASFTSMVSLTAAAFIDPVRDIYEAFTIYTFFQLLINYLGGERALIIMAHGRAPVEHLWPMNHILRKVDISDPHTFLSIKRGILQYAWLKPILAIAAIVMKATGTYQEGYISAKSGYFWSGIIYNISVTVSLYSLGLFWVCMHRDLTPFRPVPKFLCIKLIIFASYWQGFFLSILVWLGAIPDNVQGYTRDNLAAAIQDALICVEMPAFAVAHWYAFSWHDFADNSILSARMSLHHALKDSFGVKDLIEDSKETFRGNNYGYRAFDSGDKVMAHEDSQSRLARINAGMRYERGGKAKYWLPKPGDVSATSPLLGGPSSSRTGDTLFEQQHGTFDEPELDEDEERLYNSARQLKYGDWNYPVITASEPLAERYRSSMSSHNGTSPAWSTRSARPPPPQAANSNSGSSRQSSSQRIEEPQPVVVVKKKKKTKKVVKHPESDPAGLGLGKGAPAHSPDPTGTTDASASVQKPEPEEAGQGGDSAATDEGQQTHRYHVDGSDEFCNVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQA5</accession>
    <name>A0A7D5UQA5_9HYPO</name>
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        <submittedName>
            <fullName evidence="8">Histone acetyltransferase type B subunit 2</fullName>
        </submittedName>
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        <name evidence="8" type="primary">HAT2</name>
        <name evidence="8" type="ORF">G6M90_00g003500</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014686520.1"/>
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    <dbReference type="KEGG" id="mbrn:26245037"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CAF1C_H4-bd"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
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            <begin position="30"/>
            <end position="100"/>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="QLI64234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="439" mass="48877" checksum="891AD47749B69EF5" modified="2021-02-10" version="1">MPPAQASDPEVDVDMAHEEDDDQVERLINEEYKTWKKNSPFLYDMILGTALTWPTLTVQWFPDVKEPEGKNYRMHRLLLGTHTSDESANFLQIADVQIPKAVAPNPANYDEERGEIGGYGNPGDVAAIKCDIVQKIEHPGEVNKARYQPQNPDIIATLCVDGKILIFDRTKHPLQPASLGKVNAQIELVGHKAEGFGLAWNPHEAGCLASGSEDKSMCLWDLKTLEAESKILKPFRRYTHHTQVVNDVQYHPISKYFIGSVSDDQTLQIVDVRHDNTTTAALVAKRGHLDAINALAFNPNSEVLVATASADKTVGIWDLRNVKEKVHTLEGHNDAVTSLSWHPSEAGILGSGSYDRRIIFWDLSRVGEEQLPDDQDDGPPELLFMHGGHTNHLADFSWNPNEPWLVASAAEDNLLQIWKVAESIVGKDDGELPVDELDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQS3</accession>
    <name>A0A7D5UQS3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">K(+)/H(+) antiporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KHA1</name>
        <name evidence="10" type="ORF">G6M90_00g025320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692565.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26237495"/>
    <dbReference type="KEGG" id="mbrn:26237495"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="384"/>
        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
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        <location>
            <begin position="58"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="869" mass="93405" checksum="C5B668C8987D134F" modified="2021-02-10" version="1">MSAISSIVSAATATLSSPTATSTLRASNQGGIIDGANPTKYNPKDPIILFIIQTVLIVTVCHLLHWPLSKIRQPRVIAEVVGGIILGPSVMGRIPGFRQAIFPDASLPNLSNVANLGLILYLFLIGLETDVRFLISNWRIATSVAVAGLALPFGVGCALAYGVYHAFRSDEGLVPIKFEVYMLFIGIAVAITAFPVLCRILTELKLLDTNVGVITLSAGVANDVVGWILLALCVALVNAGSGLNSLWILLSATGFMLLLLIVVKPSLLWLLRRNGSLEHGPSQSIISLILLIALVSAFFTGIIGIHPIFGGFMAGLIIPRQDRFNIRVTEKLEDLIGALFLPLYFTLSGLNTNLGLLDSGAAWGYVFATTFAAFFSKIIGASVAARFSGLVWRESFSIGVLMSCKGLVELIVLNIGLQANILSTRTFTIFVVMALLTTFATTPIVTVLYPPWYQRKIAAWRRGEIDWDTGAPISSASSSEGPKDDSSLGLERVNRLLVYLRLDNMPSLLRLLSMFGDPSTPSSTPTPSDTGTDEIHDVSTTPPSRDRAVWAHGIRLLQLTDRDSSVMTVAQVDDFSRHDPVVNTFRTVGQLHNLSASGEVAIMPETRFAEALVAKSYSMASDLLLVPWTETGDMGDSQILSSTSVNDKIGSSYGSFVKSVFDSHDRNVAVFFSRSDPVAGGKAKSEERAKLMRQYSFGALKEDLPIAPGSNEPYHILLLYFGDEDDRLALHLVLQLCEKSRATATILRARSSVGASNSVGDALFERASSQLPASVASRVNFKTETGPSTVEELVQYAITETQSGVTESKAGPELVVVGRRVAAKLDEGKLTHRSREDLVLCLGNLAGNLVAGGVRADLLVVQAKAAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQX4</accession>
    <name>A0A7D5UQX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1774-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541383.1">
        <property type="nucleotide sequence ID" value="XM_014685897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQX4"/>
    <dbReference type="GeneID" id="26246018"/>
    <dbReference type="KEGG" id="mbrn:26246018"/>
    <dbReference type="OrthoDB" id="4935849at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32771" checksum="854A15F5DC411FB5" modified="2021-02-10" version="1">MKKQPASLNEVSRVDLDRRFDLAHVIDALTWGVSAGVSIYYTVRAPRDGPTIGARIWDQNFQYETGLTIDPNMVIAYWVGMHAALFVHMLANIFAASNDISYITISNHFSINNLLHVVFLVLFVRSAFGWAECILILNFVNLSVLYFKHSKLSHFTRISVICGPLAWNFIAILWNWAIAVTAGIGYNDTIEGFGLFFVWAILGYGVFSLLVFQDLAMAFLLAYLCASIAVAQHFLQRSDRMWIPPVVIASLLVVMMCAVAARCLWNLRAVRRKKVNESVYAEFDERKESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URA0</accession>
    <name>A0A7D5URA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g001200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542950.1">
        <property type="nucleotide sequence ID" value="XM_014687464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URA0"/>
    <dbReference type="GeneID" id="26244323"/>
    <dbReference type="KEGG" id="mbrn:26244323"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000127">
        <property type="entry name" value="Uncharacterized protein C3H7.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="752" mass="82602" checksum="10EC0F988D0F8947" modified="2021-02-10" version="1">MTAVASPPTFPQISRPAWGAISGSNPMDPDEVRGMFAPRKSLSRTNSASSLSSNASNTSVATNGSQSNGTSLSAASDLSQWSATAGPRKRPQPKTPWPPSKPDVQPDYSRLPANRPNGMAAHHNGLQPGPGQNQMMQQQQMMRGPMGAEQFPPGQPVLYLLSLNGTFERKTISVPFAPDSLRIGRQTNQKTIPTATNGFFDSKVLSRQHAEIYAERNGKIYIRDVKSSNGTFVNGTRLSQENRESEPHELQTADHLELGIDIVSEDQKTVVHHKVAAKVEHAGFLSNTNNVLDMNFGDLDPANGTMMIPNWPLQMRGRANGHALIPGPGGRMMNNGGMNNQGNGMPQQRSFFLAPVATDQILKRLTSEMRNARLQAQDLSRTNQFVNTLLTKEDVKDLEKPEVPEPAKQQQSQPSVNGGIPFRSDPKTRFSEPPAPPPQQPLPEKPDVPSLKRGPTERPKSGPPNSVAARQENMNQIIQLTEALNNAKRDIDTQTARMRELEEMLQKEREARELAEELAKRLEASTNLQMNGSVLTPADVTMTDISESAQEQEVEESGDSRSAAPEEAEPQKNDTSAEEVTASLQSRIDNMDEQMNDMREQLEQWKHRCETAESERDESRKSLAEMVVQLRAEEAKRSAAEERRRSRSRSRATESKADVTEQEAPATAPPDPEKPDKTIAATNTSKTDTEDGPTLSRANTITPLSSQRGFASRDQSLQAGLPYASMLGVVLIGMGLMAYINGWQSPPPRIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URQ8</accession>
    <name>A0A7D5URQ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g005280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542175.1">
        <property type="nucleotide sequence ID" value="XM_014686689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URQ8"/>
    <dbReference type="GeneID" id="26245206"/>
    <dbReference type="KEGG" id="mbrn:26245206"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028942841" evidence="2">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="156" mass="16670" checksum="7E62F4477CE89ABF" modified="2021-02-10" version="1">MFFLFANFIAAVPALAVPFTTTAFDIATRETAPTPSPTSGPLTKTESVTLYSVRNSVLTIPSQATPMVAVPPCVQTAVPDAKGQIAPGECGAIWSYYPIFWAALAVACLFGFLVAVHVLQAAVFKKVYVVLGHYHGHYLGDDGHSIPYVKLEEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US27</accession>
    <name>A0A7D5US27_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g005990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549906.1">
        <property type="nucleotide sequence ID" value="XM_014694420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US27"/>
    <dbReference type="GeneID" id="26239350"/>
    <dbReference type="KEGG" id="mbrn:26239350"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
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            <begin position="4"/>
            <end position="38"/>
        </location>
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        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
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        <location>
            <begin position="362"/>
            <end position="442"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="552"/>
        </location>
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        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
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        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
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        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
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        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
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            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="543"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI65575.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="552" mass="60565" checksum="0DF1FC04408C740F" modified="2021-02-10" version="1">MADWAKLKVVDLKAELKRRGLPQGGLKTELVARLEEADQETKEPDPEPEPEPEPEPEPEPEPHAENQMDNEAPAVESKPLQPINGDAASQAEEEQEVQEVQGQTKDGQSVTQDAPEAEPEQTPPQPPATTQEPTPAPAQKEESQPEPSPPSRDPQPAGSDAPMDQQHIQDPAVEAPADAQKRKRRSASPTPKEEDVARKRARADPGLAPRPYQLNHFPAEAHDAPEAEVDYDRHVEPSMHPATSALCINNLMRPLRPAELRAHIVALASAPGTSSTDDIVTKFYLDFIRTHAFVALESVSAASRVRQLLHGRVWPNESNRKALSIDFIPPEKIDSWIDMEEQGGRRPSHRWEVVYAPAADGSTTEANLVSNSVSSSSSSRPPPPTKPASVAASVPAPAPDSINSAPLGPRGTFTDSAPPTGPRGPRRQQPPPAPHPPSGEAQFTRARPSLAYHLVPEDLARRRVQNMRAFYTRDLNRDMGREINRYSFEDSDSFVDRGREIFEGIRPPHRERGGRGGGRGRGPGRSRGGFRPRSDRYIPGAGGRDEDDRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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            <begin position="22"/>
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        </location>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
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            <dbReference type="EMBL" id="QLI65278.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29960" checksum="BFE8EDF87ABBBDED" modified="2021-02-10" version="1">MKTITRLVTSALLLGAQTAMANNAIPGNAFTNNNGLAAAEAAAPMWYMPSGTCMPSAAEDGQGHQTNGVDTDNCNINKLSHNCPPQPQWQGTNTFYGNVAGEPFSTIPTYWSAKKCANTWKIIYYVYFKKDTGHKSDWEGIVVSFRDTGGDNWVRDTVKMEQDSNHKQINWGDVNDTFDGTDDWQAFRQRNRDHGKFYFGKFHHSVHQDWHTTSFKDTCPPNSGDDFRNGDYQFWARNNLRHVSVLNPAWNWGKASSPANIDLCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="QLI65514.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55310" checksum="FF5D471C18011CFA" modified="2021-02-10" version="1">MTSKPQVHSQFTVSSGCLCYGHLHNMWHGKSMPIQPFPSALERETGGTVLCQLVHFNIAAQNGTWLAYQLMDNRTNEVAAWFVCHSHVNPETEIDKILRVSGAPHEDGSGSRFLDESTVAEGVLPINRYDWGYYDYRCRENVTDTEEEANESEDTYVYGEHVGLVDYGHAEEYIEKWKGVRAHKRANQTHGLWMTIESEYMFGRFGFNNDRTAARSFLWFAIDTRFTQTTFAGTERTLRVEALEESSEEKFQRQLREGCKLDGLDELHEQIKLFDMVHEIPPEAECFGPYDANEHILHAADVDALRLALQLPGGVGHPEFPGPLKDANVALLNNVLMSYLEKVMVPASSAQATTSSIAASLFPDYETLQSIDGQMYAAMTRPNSRSIEGYDGVAVGERIQRFFALRCGDSNLARDGEFIAGLVAVVAYLVSELLELADNYRRDCMVSGTGPLHLRLAVKNDDDLLDMFRFSKMYWYGDGTEPDAGEGTVGEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USI5</accession>
    <name>A0A7D5USI5_9HYPO</name>
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        <submittedName>
            <fullName evidence="7">Linear gramicidin synthase subunit D</fullName>
        </submittedName>
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        <name evidence="7" type="primary">lgrD</name>
        <name evidence="7" type="ORF">G6M90_00g017660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
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        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693278.1"/>
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    <dbReference type="KEGG" id="mbrn:26238208"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="534"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1281" mass="138205" checksum="E9A04717E7177AFF" modified="2021-02-10" version="1">MSIIDTTRDLAALFEQQAQATPQAIALEDEKRTLTYAELDSETWALADRLRQYGVGRDCLVGVLMNRSADNVVASLAALRAGGAYLVLELAYPAALLRDVIDDAMPTVIVTQKAHASNLNVDIPVIIIDQPDMTVGANEPILVEPKPPLPAEDDLDRLAFVSYSSGTTGKPKGIANPHRASVCSYNLRFGLSDLKPGDRVACNVFFTWEMLRPLLRGATTVAVPDSVSYDPEGLVEFLAARKITDTLMTPTLLATVLTRHSSLADTLPHLKSLWLNGEVVTTDLCRRAFTALPAVRLLNVYSASETHEVAAGDIKSFIDYEARVCPVGPPMDPSTIYILDDAGNRVDIGTSGELYVGGDMLARGYLNLPETTAKAFQIDPFSTGLDARMYRTGDMARMLPSGLLEITGRVGGMIKTRGYTVQPGAVETTIVKHLAVRACAVVARGDGLDKQLVAYVVPDKGEIRNRTVLVVDESGYSPVARRALSDHLAHYMIPTLWVELETLPTNGVSGKTDLKALPPPPSPKTPNINAKKEHDTRIKMDTIIKMWALSLNIPATAISQSHTFFDLGGHSLTLADLAGRLTRTFGFPIPLAPLAGTPTLEGHMEAVQAARDGHTAAVQADLPAVLLADSALPDDIKSNGKPMCRLGDAETILLTGATGYLGAFLLKSLLESTSAQILCLIRFTDPNIDCRPAGIARIRKNLIDQGIWNDAMLERMEVVPGNLARNRLGLSPEAFQDLASRVDVIVHAAATVNLVYPYAALRNANVGGTREVLRLASRGGATVHHVSTNGVLPPSKTAWTEEAMLDIDDVPTKLPDGYGQTKWVAEMLVYEAGRRGMHVKVYRPGTISGHSLTGATNTYDLLNALIVESLHLGYAPKVDGWLAEMTPVDFVSQAIVTLANHPCTKQKLYHLGDPDPVTAENVFQDLEALGYPTKRLPWDDWVALWKEKRGSGRGGDDPFTVDILRGGMPTVDTLELVTILSDGATQPALDLYGVSRPKIDRNLWETYARHFFARGWLPRPPLRLKLNGVHPHPKKGRLSGCVAVITGASSGIGAAVAAKLAGEGAHIALAARRIDELEKVKTKLSTCSGKILVHKTDVTSKAQVESLMKTATEKLGPIDILVSCAGVMYFTMMANCQTEEWERTVDINCKGLLHCLSSTVPGFLERKRGHIVAISSDAGRKVFPGLGVYSASKFFVEATLQSLRLETVGSGLRVTAIQPGNVDTGLLNISTDAEALKKYGEPTGAKVLDAEDVAGAILYAVTQPEHVAVNEVLIEPRDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UST8</accession>
    <name>A0A7D5UST8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g009130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549597.1">
        <property type="nucleotide sequence ID" value="XM_014694111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UST8"/>
    <dbReference type="GeneID" id="26239041"/>
    <dbReference type="KEGG" id="mbrn:26239041"/>
    <dbReference type="OrthoDB" id="4716584at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="618" mass="69824" checksum="046CED26FF8CD14F" modified="2021-02-10" version="1">MASLNLAKRSFAPVPIETTFQSNRKGTQPGGQPGGPNPELTPEPSPRSASPPMPQPRQRRRFKPQLIETSRRTRRVGDPGPATRPTDKTDITPYTNHIYVAKPKPRRKHGEALDDESIPWIPPTRRESEDEGVKEYLLEIAAREAARQMEEAALAAFPNSRAREGGVAHFYFRESSESDNSAENTPQNKDNGMQPRVRRKSSNLGLNWWHKHMQSHAEQLAYERGDDEMAFGGVDEDTIMRTDSDLDKMDLPVPPDPLWTTTNRIPPEDRRDSMAELQDLRDSLTPLSRPDAAFTIGNRFQPGDAAYGRPSPDQRDVGYSPFLRPVDRGPDVAFGRPFGAFGLKPEDPKLHLMRQAASPPMLGKDLTFRRCPSPKQTKLETDHPFANHDVYKEQNRDVTGQGGLWRGFCCRSESNTEYVVPAEFHGANMLVTPYPPASPRDGAGFDSPSMSDEPESMFSSSNSSESLNNISPTRAEHRSRTSQSKGLHMLHGLDDRLRREKAQVELDEKIASEFDDEFVTQVYNYLSLGYPATARYFDGELSKISRVSVEELCRDDERQMAKGHMLEMSLQATSETDRCPRWKALRTYVTEWARQHPDLDNLDPLAWGVRERRGSWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USW8</accession>
    <name>A0A7D5USW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g013180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549203.1">
        <property type="nucleotide sequence ID" value="XM_014693717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USW8"/>
    <dbReference type="GeneID" id="26238647"/>
    <dbReference type="KEGG" id="mbrn:26238647"/>
    <dbReference type="OrthoDB" id="5352472at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="341" mass="37556" checksum="B0D5B9E30190CD4D" modified="2021-02-10" version="1">MPVQLLPASAAAFAPRAPSVNVVLASKVEPWLTQTLKRVNKVKRPLNSVPQHQRCLTETLSSPNAIWTLASLMLSKLPEAEMPREPLEELFSYQLVHVEAYIVHVDMVLRNEVAYKLTTDTIDALVEYHDKIHCADAKASTYDWSEKEQQCKKLHQDFVQAINKFVYRTHVSALEGLEEEGAGELLCGRSEEVRNSLIGLMKPLLPPPPRVVDVVRQPTLLPSSPVNNMWSSQPTMPSSLPAVEPWRVLPSSPSVPSTSAEPNNPPMWATMGINELQMPSPAPAFTQPHATAALYFTSPPITAPMPAALPLPSMLSSSQCGVSVGMGGFGWDRYQEYATIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT16</accession>
    <name>A0A7D5UT16_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fcyB_0</name>
        <name evidence="11" type="ORF">G6M90_00g014440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549078.2">
        <property type="nucleotide sequence ID" value="XM_014693592.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT16"/>
    <dbReference type="GeneID" id="26238522"/>
    <dbReference type="KEGG" id="mbrn:26238522"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="520" mass="56469" checksum="279B9A6E97AD6D50" modified="2021-02-10" version="1">MSMDEEKGQGIVPKTPGEKDALDVDSSDKADQGAAGSTRSGILAQLRNLEARMDAKFGIESEAIVRKRAEDKKDVPWTEELTMALLWASGTMNTSCFATGFLGWQFGLSLKQTILITIFASILGGIVTGYCATFGAATGLRQMSVSRYSFGWWPNKLIAILNCIQQMGWAAVSCITGGLALTAVSDGHVSLILGIVILAVVALLISFVGLNAILVYERYAWIVFFVIFLIIFGETGKYADNSTPASITGATLSGAVLSLIAIVYGSSAAWCTTASDYYVHYRADVSRTKVFLMTSFGIAIPTSIGMLAGCVVASSLNTQAEWRDTYEHDGLGYLIQDMLYPRGFAKFLLTLLVLSGINTNVISIYSASLSFQQLARPLALIPRFVWTLVSFACILALAVGGREQLNTYLQNFLSLLGYWCTSYAIILLEEHYIFRKGKFENYDFEGWNDPARLPLGIGAATAFGLGVVSWCMGMNQTWFVAPLAKVIGDNGGDVANELTFVVTALGYLPARYLELRILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT75</accession>
    <name>A0A7D5UT75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g002910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986044.1">
        <property type="nucleotide sequence ID" value="XM_066129541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT75"/>
    <dbReference type="GeneID" id="26244165"/>
    <dbReference type="KEGG" id="mbrn:26244165"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="772" mass="90249" checksum="BCBBCA998F288A9D" modified="2021-02-10" version="1">MATSAEKPSKTGDVVASHSAPRKFKASDLPLSSATRAAIESLKHSFKKGGAYDSIRKQVWDKFGASDCETIVKQAILEVAEKEVDRNPQQLLTLDPRKASALIDGALERSGVYQKAEGVIAKLIDVDAIEERIREIRRAEIGEEAAESERIRGAKTDEEYAADTEARQAERERVREELRLKEAAIEEEKRRIKQEEQKKEERERAQAELKRQAERDERRRKREEERAERERLRDLEREKRHKEREARDKEREQRDRERSRDRSRHRSRNRSRDRSRDRSRDRSRDRSRDQDKDKDKDRGRDRSRDRRRDRSKTKETASDQKMSKEDNERLEQEALADLLRESSRSDQAKPELEVDAALAPPPRKSAPASAINPIKRDSRKASENGSRSERRDSRTAADSKLSGSRDEKRSSRSASRAGDRDREKEADLVTGTGATEVDQNCDGIGPGLGRGETSAVSEVVHGIVTTGVGVGRDEENAPDPPHDLNGVNGVGPAQGQTVGTEAVSETDPARRPGQKDAGVGLEDASGVDQGTAAAAGERARDRDRDRDRDADRDKPRDRDRDRRSRSRSRPGTSVVRTASAAREEHEEWKLEEVRKREKEAKAYLAAQKDAKAKGLPIPGVDDKKPVRDDRRRSRSRSHSRDRTRYRERERERDRDRDTDRDRDRDRDRGRDRDRDRERSRERERERERHDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRDRNRDRDRDRDRDRDDRRRRDRSLSPRRERRRSRSTSRRRRSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTM7</accession>
    <name>A0A7D5UTM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ODBA</name>
        <name evidence="11" type="ORF">G6M90_00g036250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547018.1">
        <property type="nucleotide sequence ID" value="XM_014691532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTM7"/>
    <dbReference type="GeneID" id="26239581"/>
    <dbReference type="KEGG" id="mbrn:26239581"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="98"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI66576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="450" mass="50684" checksum="4391CB8E716940CB" modified="2021-02-10" version="1">MKSRVIRNLPIRRATTSIPKTAFATPVRAASSVSQRPNSDHVSFPGALKSAFTTQLSFEHPESYKALPTYRVVDQHGAVVDQSFQPDISDETVVKLYKDMLFISIMDLIMFDAQRQGRLSFYMVSAGEEAVSVGSSSVLDPEDPVYCQYREQGFFKERGMTTKEFMSQLFANKNDPGKGRNMPVHYGSKRLNIHTVSSPLATQIPQASGAGYALKMQKLQDPNSKAKVAVCFFGEGAASEGDFHAAMNIAATRSCPVIFICRNNGYAISTPTLDQYRGDGIASRGIGYGIDTIRIDGNDIWAVREAVKKAREMALQDGGKPILIECMTYRVSHHSTSDDSFAYRARVEVEDWKRRDNPITRLRKWMEAKGCWDETKEKEARDSLRKEILKGFSEAEKEKKPALRTMFEDVYEELTPDLKAQIKELRDMLDKYPDEYDFSEYDGGKESLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UU79</accession>
    <name>A0A7D5UU79_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g030420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539462.2">
        <property type="nucleotide sequence ID" value="XM_014683976.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UU79"/>
    <dbReference type="GeneID" id="26247736"/>
    <dbReference type="KEGG" id="mbrn:26247736"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="329" mass="37734" checksum="212C978F3DCE9A28" modified="2021-02-10" version="1">MDREFGSWLQTVTHEDDSLACCLSAHDAAKSQFMATLTLEAQSEDRQRGPLDGRGPFATARHYIGRLGYRITAHKQLIQDACSLGYLLGTFNVRLVSPVRSVSQPQPDSHTSLNGILSRMLKKGDPERSEIERSLHNINRQSDIFRGFMEEFSNCKPTVHAEIQVLEHFFNNKLSFVANDKYIACSKAACFCCKLYFQHHPARMVIPESHEKVWTSWGPPAVTFFRKQNDESDRQRDILNKIIESLRTDAIYQILKCSQPPVWHPDSQTAMSDIITSCKGPLYPQRRLLTNETLHTSSKRQRLIGSRIGNHPRFYRTSLIDAVEYQEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUM6</accession>
    <name>A0A7D5UUM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Reducing polyketide synthase swnK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">swnK_1</name>
        <name evidence="10" type="ORF">G6M90_00g032310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543166.2">
        <property type="nucleotide sequence ID" value="XM_014687680.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26243967"/>
    <dbReference type="KEGG" id="mbrn:26243967"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08956">
        <property type="entry name" value="KR_3_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF51">
        <property type="entry name" value="INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="523"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="616"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2001"/>
            <end position="2076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2479" mass="266118" checksum="CDC080357FC4EDFC" modified="2021-02-10" version="1">MSGISDHDYQVLVNEFNATDDISLLGSRLDQLFEQVADRFPDNTAVIHNENEVTFKQLNSSANILARCLAKRGLQQGDVVGLAVSRSIDLIAAMLAVLKLGAAYVPIDPSFPAERINQMVEDAGLRLILLSGRPTKGLGRWADLCLSVSEARDGSVTDGTNLETEIQKRDLAYVIYTSGSTGRPKGVEISHGAAANFLSSLRKHEPGCSERDRLLAITTISFDMSALELLLPLVSGSAMVIANTSAVKDPRELISLMARHKVTILQATPATWTMLLESGWKGNPRLSKVICGGEPLSRQLADRLLDAADSVWNVYGPSETTYGSVGRVGQGDIVVGNPVANGRIYVLDDNMSPVPIGSEGEVYIGGGSVSNGYRNKAELTRSRFLVNPFHGGVFFRTGDLARFIAPGKLQVVGRIDGVVKIRGHRIDVGDIEAVLVDHANVSEAVVVSRDDRLVAYCVLHAPCHDAASLDGILRPWVAERLPAYMLPTFFVQMDALPLSPSEKVNRKALPDPIEAMQHQTMIQPTSELEQRIQAIWSDILGHDRFGTEDNFFRIGGDSVRIIRMQAALEKQLHRPVPTPKLFEHYTIKTLAAYLAGAGRENNNESQAVSQTFAGSHEDIAIVSMACRLPGGVATPEALWQLLQSGGDTIIDVPKDRWDADKLYNVDANIDGTSYCRRGGFLDEIYSYDASFFGISPREAQAMDPTHNLMMELCWEGFERAGYTRDQLSGSATGVFLGVSNNATTNGTPPDLEGYSITGSASATMCGRLSYTLGLRGPSLVVDTACSSSLVATHLACNALRQGECSMALAGGVSLLTTPGIHIEFSKLGGLSADGRCRAFSDDTDGTGFSEGAAIVVLKRLSDARRDGDDIHAVLRGTAVMHGGSSAGLTAPSGPGQVALLRNALARAALEPGDIDYVEAHGTATKLGDPIEATALAEVFGTERSGSDPLRIGSAKSNLGHTQAAAGVVGLLKVVLSMKHDTLPRTLHVREPMAAVDWKRANMELVLANRPWLPNNNRLRRAGVSAFGIGGTNAHVIVEESPTPAVEETSNIAPPSLPATIPFVLSGQGDSALRAQAERLRLHIESGAGKDSRLRDVAYSLATCRSHLHRRLVVMAGDKAETLEKLASVSSGPTQPLSVNEVGSPTVAMLFTGQGSQLPGMGKDLYAVYPVFRDALDEIATKFTDLERPLLDIMWAESGSENAALLSRTDFAQPALFALEVSLWKLWQSWGVKPDFLLGHSVGELAAAHAAGVLDLSDACRLVMMRGRLMQAIPRQGKMASVEASSAEVSAAIQELGQHDKVEIAGYNTPLQTVISGDVEAVEAIFDHMQSLGRKTKLLDTSHAFHSFHMDGMLDDLRALAQNIRFSPPKMRIISSMTGRLAGSDELERAEYWVQQARNAVRFSDAFQTLAGQGANVFLELGPSAMLCGLGAACLADPGQVGAALWLPSLKPNADGPSVIQSSLGELHVRHVPVDWAAYFKPFGCKRVMLPTYAFQREDFRPANKAIWFDVVSPSTGTDAAPRVQDMMFEINWRRVETKSIQPRGAWGLLCPSGETAWTTEAQRALLATGMQLVAVSEPHEADQLDGLLTLWDSDADTVQMAHRVTAVALAQLQEAIRTGLGAPIVWVTRHAVGAGADDRPVNIGAGPLWGLMRAARSEHPELRLRLIDVDEETDRASLSQALMLADQTEIAVRREQLLTPHMERAGPAAPLPVGQPFVRTDGAVLVTGGLGDLGSRVARRLATAHGVRDLVLVSRQGTNSPGADALVAELAELGATATIVGCDLADLDSVGSVVQLFTPDRPLRGVVHAAGVVDSGILSSLTARKCAAVFAPKVDGLWNLHQLTKHMDLDLFMMFSSISAIIGLPGLGNYAAANSFIDSLAHLRRAQGLPASSVAYGTWAGDGMATTLVPTTRAHLAQLGLGFLPPEAGLEIFEQAVYQGRALTVAAVLDLQRLGAYYEEQGGVPPLLHSMLGGTKVQKPADEVVNLRDLLADASPEKYGSIVLHMVQETIAKALGYTRTEDVDASRPMHELGIDSLTAILTRNHLATLTGMALPPNIALLYPNLKSLSEFLLCRLLDDVEGSTSSPSDTDGATPSTPTSAASCVDMADIRRGVLDSTFQFNNPVSPGVPETVFVTGATGFVGAFMIHEFLQRRISVYCLVRASGSQEAQQRMIATLKQYGLWRPEYEPLLVSVAGDLSQPLLGLGEVVFDDLASRVDAILHSGALVDWMRPLDDYIGPNVLGTHEVLRLASCGRAKAIHFISTISTLPIHAGYGLAEHDGEYGYGTSKYLAEKMVVAARFRGAKASSYRLPFVAASAASGRFRLDRGDFLNNLVTGSLDLGAFPLINADLSSVLPVDYLCGTIAAIMTEDQERVGEDYDFVNPQAPTFKHFFEMICAVGGGKETVSFGEWHRRALEYAAAHPTSSLARIATVLDGYNDKTVGSLVSGSPVGKHVLGLDAYRAPPLDEEYVRRWYTSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUZ0</accession>
    <name>A0A7D5UUZ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Shugoshin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sgo-1</name>
        <name evidence="13" type="ORF">G6M90_00g033560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543283.1">
        <property type="nucleotide sequence ID" value="XM_014687797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUZ0"/>
    <dbReference type="GeneID" id="26244084"/>
    <dbReference type="KEGG" id="mbrn:26244084"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="563"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI67914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="632" mass="69588" checksum="3FBA29B793D0EBAF" modified="2021-02-10" version="1">MARLNEVPMSSDSLETLRKKMLRQNRDLAKSNNVRALRIRELESECALMLSENLELRSRILELEKQVEDNEARRIADHALAIKAKLESQLTEWGTLLSGLGLEPPMKRHSPRIQKSIKQRMSYIAGRPSPSQRRLRDVARDIEELGHISENRSSSRQSLNPEQIRALRSEADSAELEAPAKQPLIEQEPTKVDSPPRAALATKDVSSPRRLIEPPISLPSPRSSKIADAPLPSPEKKRTEPSNRRQNPILQPSTPAPEHIAAPVKTGSKRKFAQDETENTAPRQLTNENIAPRGMADKVSIREKAGGKTLKELAHMRKEAREKHVTTGNSRKPLASKSTNDDVSSPRKNPKPIAIDEVGTGKAELAKSKPTKERTKSKAKMNAAAKLEIPPPVTKTVIADLATTVSEPAVTSPKSPEPALGGDDPRGDTPPPVDIFLNGETSRASRRNRTTISYAEPNLRDKMRRPTKELFDAVAGEGKYARRASQCDLPTSEGPKIKRESDVGDSLRRIPPTSDEFEAPEPGSIPASPLAKKSSAQDASAAVITERRRPASRAGEFAADLNLDADENESGDVDVYEFTSSSPQIDNNAPTETTRATRRRGANTRRRSAAVDSEEDSSVKERSVSRRRSMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV20</accession>
    <name>A0A7D5UV20_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">37S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MRPS17</name>
        <name evidence="5" type="ORF">G6M90_00g042510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986308.1">
        <property type="nucleotide sequence ID" value="XM_066130302.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90967678"/>
    <dbReference type="KEGG" id="mbrn:90967678"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
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    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="128" mass="14390" checksum="38C6458A28C62F26" modified="2021-02-10" version="1">MSSQVAKAARRVAHELHGVVVSAGLMQKTVKVRVGGQKWNKVVNKWFPDPKHYLVHDPNSSLRTGDVVSIVPGWPTSRHKRHVVKHIIAPFGAPINERPPVPTLEERIEDRETKKAAKAERRLSRTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVA6</accession>
    <name>A0A7D5UVA6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g033830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543310.1">
        <property type="nucleotide sequence ID" value="XM_014687824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVA6"/>
    <dbReference type="GeneID" id="26244111"/>
    <dbReference type="KEGG" id="mbrn:26244111"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="458" mass="51347" checksum="C4ABA92B099954C2" modified="2021-02-10" version="1">MPFDDDDNLAAEPSAQTPNGGPTTEDALEDGVPDYKLFSAMFSKKPVSSKVIRKGEKDFESHGTQAQDNTLEASRQALEEVLSYTRVHRPENWIRAWYFPDWWTQQRPEGSQEDALLHERVVAVEQERGSWMKDIGRAVSGSKDQLGVGRLWLLPEEALYLIERGNVDIWWPDKEFGELLPLGVGNGPGRNQFGPDDYDAGVPLTVEAAYAMMVGYEGERGKTTLSKYQVYTHLKRAGFNVMRAPIHAPPEPTAPSSSSQSLWQWLFSFVSRESKSRHGPYGPLVSPGLYRAYLPVYQQLAVIPRHKPSAHPEEHHHVQEPFRVHFHVWKPAGIPFSKKNPPPPDFRIAVADTADSKLPTLEQIEALLESTPFDLPNPKWQGPGKLYQRLKHGHRNVLVAVVDRGLVNFMRFGEAAFGAERLFERFDSRGSGTRGGRKGGRGRGRGRGRGRGGGRATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVR9</accession>
    <name>A0A7D5UVR9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g049720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986290.1">
        <property type="nucleotide sequence ID" value="XM_066130473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVR9"/>
    <dbReference type="GeneID" id="90967746"/>
    <dbReference type="KEGG" id="mbrn:90967746"/>
    <dbReference type="OrthoDB" id="10280895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="75" mass="7412" checksum="C2A6DA15DC413AF5" modified="2021-02-10" version="1">MSAPSDEAVSAGYTELIACNGNFGDMFWPVDEAAEDGGSSVGVENGSAGPDNTESQVKGGQHGGETGGSCSNGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVU8</accession>
    <name>A0A7D5UVU8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH kinase pos5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pos5</name>
        <name evidence="9" type="ORF">G6M90_00g048410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544956.1">
        <property type="nucleotide sequence ID" value="XM_014689470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVU8"/>
    <dbReference type="GeneID" id="26242297"/>
    <dbReference type="KEGG" id="mbrn:26242297"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI68177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="480" mass="52528" checksum="762CE6AE83B54578" modified="2021-02-10" version="1">MSRRQLLQELLASTRQSGLGGQPRAPASLPRRRTTSETPTCSSRHNFSTSLPLRSAQVHSVNELPDRTFPRYLQSTKPGSSLLSLHWPRPPRNLLLVQKLYAPDVTESVIKFAKHIRTDYPDVNLVVEPRIAAVIRNHLPFPIYVSDSRSNTAGKIDVIATFGGDGTVLRAASLFKLHGSVPPILSFSMGTLGFLGEWNFSEYRKAWREMYMSGSDVASVQDAAVPIDNGRDERMAANTPADVAGWERLRGKSLGVGRASKILLRHRLKADIFDRSGDNINHQVSDTLAHQHKSSIAGTQEPSPSLRAINEISVHRGSHPHLAIVDIYQNGHFLTETIADGILISTPTGSTAYSLSAGGPIVHPLVKSLLITPISPCSLSFRSLVLPLDTKVTLRMSPKNRGRELDLNIDGKRCAGVLPGSEIRVEGEFVGRAGPGEEWHGGVPCIIRTEDDDPWVGGLNGLLKFNHPFGREPPSDEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVZ8</accession>
    <name>A0A7D5UVZ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g050250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545132.1">
        <property type="nucleotide sequence ID" value="XM_014689646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVZ8"/>
    <dbReference type="GeneID" id="26242473"/>
    <dbReference type="KEGG" id="mbrn:26242473"/>
    <dbReference type="OrthoDB" id="4961439at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34696" checksum="72570395968B2611" modified="2021-02-10" version="1">MNVKNWNDRADKDLFFTILSVKNIGVISGAEWTTIGNHMRTLGYGFTNEGCRQHFQGLRRSQNKAEANGTAPELSRRVDPTLNPITRRPGPGRGRPRKPENEAVSPVDGGIGPASVSMPASTASAASASASAAAAAFHAVHAVHAVHPAHAPSITLKQEDTADQQRAQQSQQQQQQPLPQQPQQQPQQQPQQQQPPLQPQQQPPLQSLQPPPPPPSPPQPLKSESIVETTPEFTTPPVEALATAPATETTDAADGTPVVEQDGDDDADAPEEPPTKRQRLDTQELEQQQPLDDEAVLALAAHNGATESDYPEEDDNYGDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW85</accession>
    <name>A0A7D5UW85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MFS transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g040220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547371.1">
        <property type="nucleotide sequence ID" value="XM_014691885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW85"/>
    <dbReference type="GeneID" id="26239934"/>
    <dbReference type="KEGG" id="mbrn:26239934"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028878416" description="MFS transporter" evidence="2">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18425" checksum="9809B1447BEFAB81" modified="2021-02-10" version="1">MARIQALALILASLLALVSASSAPTFCKCTCFKNSTIIPLGPKGESSGSPSNSFLSFSLFSESNPSGAAASDDATDDQGLSRRSLSTSCSECTKSFCLSQGIDFCKEAKEENVVTMCFQRDSNKDKIIVWGFILGTVGLLGWAAFKRVVEVRGKRAMSRQDISYAPVSGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW95</accession>
    <name>A0A7D5UW95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Glutathione reductase</fullName>
            <ecNumber evidence="3 17">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">gtr-1</name>
        <name evidence="20" type="ORF">G6M90_00g048790</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 17">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="14">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 17"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544991.1">
        <property type="nucleotide sequence ID" value="XM_014689505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW95"/>
    <dbReference type="GeneID" id="26242332"/>
    <dbReference type="KEGG" id="mbrn:26242332"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000141">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 14 16" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="8 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 16" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="19">
        <location>
            <begin position="9"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="18">
        <location>
            <begin position="356"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI67899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="469" mass="50666" checksum="8B6639F9BF9DECF9" modified="2021-02-10" version="1">MAPITKETDYLVLGGGSGGLGSARMASSKFGAKAMVVEAARLGGTCVNVGCVPKKVTYNAAAIAETLHEAKSYGFSVTETAPFDWTTFKNKRDAYVKRLNGIYERNLGNDKVEYLHGWGRLLSKNQVEVTLDDGSKVVVNAKKILIAVGGRPSSPPQIPGAELGINSDGFFDIDKRPKKVAIVGAGYIAVEFAGMFNALGTETHLFIRGKTFLRHFDPMIQETVTNEYERLGVNLHKESQATKIEKDANGKLTVTYKDAEGKESSVSDVDHLIWAVGRTPMTKDIGLEEAGVKLTENGHVQVDEYQNSSVENIYALGDVSGEVELTPVAIAAGRKLAQRLFGPAEFSTQKLDYSNIPSVVFAHPEVGSIGLSEPQAIEKYGKDNIKVYKTGFTAMYYAMMEPEHKGPTNYKLIVTGPEERVVGLHIMGQGSGEMLQGFGVAVKMGATKADFDSCVAIHPTSAEELVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX90</accession>
    <name>A0A7D5UX90_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">clptm1</name>
        <name evidence="8" type="ORF">G6M90_00g063050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542577.2">
        <property type="nucleotide sequence ID" value="XM_014687091.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX90"/>
    <dbReference type="GeneID" id="26244526"/>
    <dbReference type="KEGG" id="mbrn:26244526"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="614"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="659" mass="74211" checksum="5B0AA32A978F08FE" modified="2021-02-10" version="1">MSGLDQVIRQQPEGQPQPQPERHGFNFNKLLLGGAAYLGLNLALSYFLAKDQRGVQVTDPNTGKPITVASNLGDIPAFELRPSQLDEGAQYRPIPRKIAPIWPQDSHVDIVVTLSPSFNPTPISETPAEYVVLQERNFQMSNSSEKRTVDTKFTVPRAVQFNGTLWGHFYVGLTGSNLDPRRPGYDPAKAYHFAYPLTQYLPKKKVAKTRNLLDSHSEDEEPEEEEPTGPIITNHYHPNASFAFVPAMGVKDFNSIHPAVKHFLRLEATGARDGSGQNGWYYPVLFINNFWQLANHMTVLNETVKELPLHIDLTTMAFWKFSTLASIELSSKENARQAAFGHSLPTGGDGSEIEMVKEIFIDTNPILLGITAVVSVAHVILEMLAFGSDIAHYRKKKDNVGISVRSILANVFMQTIIFLYLLDNSQNTSWVILGSQVVGIVIEFWKVTTVVDVRFRPSAPGSLFPYTLVFEDKHKLTETEEKTKEYDAVAFKYMYMVAVPLLIAYGVYSLVYDSHKSWYSFIITTLVGSVYAYGFLMMVPSLYINYRLKSVAHMPAKAMMYKFLNTFIDDLFAFTIKMPFLHRLATFRDDIIFFIYLYQRWAYKTDFTRVNEFGQGGDEGEPSSQNGKESETIEAKRATDAKPEGKATGADTGKATKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY40</accession>
    <name>A0A7D5UY40_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g054840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540922.1">
        <property type="nucleotide sequence ID" value="XM_014685436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY40"/>
    <dbReference type="GeneID" id="26246228"/>
    <dbReference type="KEGG" id="mbrn:26246228"/>
    <dbReference type="OrthoDB" id="4940946at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028948072" evidence="1">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="129" mass="14176" checksum="C770CF5A41F8BA70" modified="2021-02-10" version="1">MMKLLTVFLAALTTTLAQDASHEDEVRKAFDVRLYAGSFADLGEIMANSLDAVKKLGQDMTALRIAGANSMSEEDKDALEYAVDFADEIRNNQDFEYLAGRARSAARVSRDVSDKANQRVNQLLGGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY77</accession>
    <name>A0A7D5UY77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY77"/>
    <dbReference type="GeneID" id="90967848"/>
    <dbReference type="KEGG" id="mbrn:90967848"/>
    <dbReference type="OrthoDB" id="10275604at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="109" mass="12088" checksum="96FD75C799812CA0" modified="2021-02-10" version="1">MASDIFSPGSSQRPDRQQGLSGCIVLFPSRSLLICTTSCRGLIGWFCSLESRENQRSTGSHAEENSERWAEKKHGEDGCKSPFETITQKCRTPKTTTDLPLGQFVIAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYA4</accession>
    <name>A0A7D5UYA4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">POLX_0</name>
        <name evidence="4" type="ORF">G6M90_00g066710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539276.1">
        <property type="nucleotide sequence ID" value="XM_014683790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYA4"/>
    <dbReference type="GeneID" id="26247934"/>
    <dbReference type="KEGG" id="mbrn:26247934"/>
    <dbReference type="OrthoDB" id="4941404at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF438">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="321" mass="36435" checksum="F57C9F0961BD7BD0" modified="2021-02-10" version="1">MVIRIAISEILLDTLDALKEAGIDRTDEEPCVFTDGKILVLVYVDDILILSPPQEKESVDKLVKYLQGKSNLREEEFKWYLGIRVIRDRPSRKIYLCQDAHVDKIARKFKLCDSKLRVSSIPITTTPLVKHDTQASKEEIQAYQEGVGSLMYIAVMTRPDIARAATQLARFLTNPSPEHLAAADQCIRYLYTTKFLAIVYYGMHVGEALVIASDASFADDAETRRSSQGYVMTLFNGPVVWKAGLQDTVTTSTTEAEILSLERTAKESYAVDRLLRDISLDLGPLKIYYDNLQSIRLVVEENQRVTTKLRHVDVQNMWLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ54</accession>
    <name>A0A7D5UZ54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUR7 family protein pun1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g074520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545614.1">
        <property type="nucleotide sequence ID" value="XM_014690128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ54"/>
    <dbReference type="GeneID" id="26241647"/>
    <dbReference type="KEGG" id="mbrn:26241647"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30744" checksum="DD59AFE97CBADC8C" modified="2021-02-10" version="1">MAAPKARRNTTIIAALLYLISIPFLILTLIGNTHDRPVLRDTYFFKLDVAQIIPIAVANSGLLNSVARSLGLHDFYQVGVWNFCEGYNDVGITYCSPPRTFYWFNPVQILVSELLAGAKIALPSEVLTILRLLEIGSKVMYAFFMAGTVINLVLLLGTPLVMRTRWFSLFLSLLGGLSGLVLTVAAIIATVISVAAKIALTAQDQLNIKANIGVKMFAFMWIGALATDFAFLLHAAMGCCCKPVRGGGGKSPNEPSPEGSAKKPMTHLELPSFIRRRKGASPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZD1</accession>
    <name>A0A7D5UZD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g066930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539559.1">
        <property type="nucleotide sequence ID" value="XM_014684073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZD1"/>
    <dbReference type="GeneID" id="26247642"/>
    <dbReference type="KEGG" id="mbrn:26247642"/>
    <dbReference type="OrthoDB" id="5151886at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="204" mass="22432" checksum="C7DAFE88CB3E820C" modified="2021-02-10" version="1">MDISQSIERSHDDDGPVGITLWQSPEDGEPNLDCHDSDPNLSVTCDNIPFGDCCAGEENELFDSAESDQAEGMTSFDLYAGSGDDPCRQIITSSSSRDKPCLAGSSAGMSITGAALEVPEDKSIGDIPGPAENSEVVVPKKRVWRASLYGYRDANRNMYYIPVKSPLGDEYRKLATRREKMEFMAKHGMSREDVREAKRQLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZE9</accession>
    <name>A0A7D5UZE9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dsd1</name>
        <name evidence="12" type="ORF">G6M90_00g078600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545248.1">
        <property type="nucleotide sequence ID" value="XM_014689762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZE9"/>
    <dbReference type="GeneID" id="26241281"/>
    <dbReference type="KEGG" id="mbrn:26241281"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI70994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="368" mass="41761" checksum="DE50CF45563CB379" modified="2021-02-10" version="1">MPSNGSATVTKTSKNKSPPPAKQDANPKHDFFWTYTEEPHRTRRLAIIKAHPEITKLCGPEPLTKYVVLGVVTLQIVLACLLQSTSFWSWKFWAVAYVFGATANQNLFLAIHEISHNLAFKSAMANRLFAIVANLPIGIPYSAAFRPYHLTHHKSLGVDGLDTDLPTALEAFFLDSILGKAFFCTFQIFFYALRPMAVYRIPFTWVHCVNLAVQLAFDALLLRYASPNALLYLLLSSFLAGSLHPVAGHFIAEHYVYETVTPTQRDPGNMVPVPETFSYYGPLNWFTYNVGLHNEHHDFPAIPWTRLPAVYETAKEFYEPLPRHESWVYAIWRFIWDENVGLNCRVKRKEGGRLVGGAVNWKETEVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZF6</accession>
    <name>A0A7D5UZF6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ubc14</name>
        <name evidence="4" type="ORF">G6M90_00g068980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539996.1">
        <property type="nucleotide sequence ID" value="XM_014684510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZF6"/>
    <dbReference type="GeneID" id="26247216"/>
    <dbReference type="KEGG" id="mbrn:26247216"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="189" mass="21309" checksum="E28017973595562A" modified="2021-02-10" version="1">MSTKRISKVHIPPGPHAASIFFPLSTKEEEKPNPRQEYAEISQSPPEGFTISLPPNESIHTWQITLVPPPASPFHPGKYGILLTLPVEYPFKPPAVRFTTRLYHPNVTNDSLGNVCLGILKPENWKPSTKVAAVLDALRNLLVEPQPDDPLEERIADEYRNDRPAWDKNVRLHVDKYARGEPVFPPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZG7</accession>
    <name>A0A7D5UZG7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">leu-6</name>
        <name evidence="13" type="ORF">G6M90_00g071220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545936.1">
        <property type="nucleotide sequence ID" value="XM_014690450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZG7"/>
    <dbReference type="GeneID" id="26241969"/>
    <dbReference type="KEGG" id="mbrn:26241969"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="66"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="223"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="838"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="12">
        <location>
            <begin position="986"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI70273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1123" mass="126195" checksum="79F6CE95BC9A903A" modified="2021-02-10" version="1">MATNSVPKAMEALSISKTKELKGTEKRDSLIAVEKKYQQKWQDDKIFEVDAPTTTEVPLHSIPAAELREKVPKFFGCMAYPYMNGTLHAGHTFSASKVEFAAGVARMQGKRALFPMGFHCTGMPIKACADKLINEIGKFGEDFSGYNEEEDDAADEKPAAAPVSHTKEDITKFTTNKSKTKAKTAKMKYQFQIMQAIGIPTKEIHQFADPQHWLKFFPPLAIQDLTSFGCRIDWRRSFITTDANPYYDAFVRWQMNRLKELNKIKFGKRYTIYSIKDGQPCMDHDRAEGEAVGPQEYTALKLKVLEWSPKAAEVVKGKVPDNAEIFLVPATLRPETMYGQTCCFVGPKITYGLFKAGENSYYVVTERAARNMAYQGILAQEGVVEKAGEIQGTDMVGTLVHAPLSCHKEGVRVLPMETVLPTKGTGVVTSVPSDSPDDFATVTELAKKADYYGIKKEWAELEIYPIIETPSYGDLCAPFLIKKLKIASPKDTKQLEEAKELSYKEGYYQGILKVGDFKGEKVETAKPKVRAQLIDAGDGFAYSEPERKVVSRSGDDCIVALMDQWYLDYGEEKWRETALKWVENADGKGLNTWTAETRHSFEGVLNWLNQWACARTYGLGSKLPWDPQFLVESLSDSTIYMAYYTVCHWLHKDLYGREKGVGNIAPEQLTDDVWDYLFCRRDLSEDILNSSKIPKATLESMRREFEYFYPLDVRSSGKDLIPNHLTFFLYIHLAIFPPEYWPRGIRANGHLMLNGEKMAKSTGNFMTLRDLVEKYGADASRIAIADAGDGVSDANFEEDVADNNILRLFNLREWCEEMVRDEADLRTGETNTFQDALFHNEMNGAAREAIDQYAQTNYKLALKAALYELTGARDFYREACAAGGIKMHKDLVFKYIELQALLMAVIAPHWSEYIWLEVLKKPSTIHDATFPSIPPVDATLSAKRDYVRNTASNINSAEGLQLKKKAKGKETSFDPKRPKKLTIYISDKFPAWQAKYIDLLKEMWDPATKSVNDKELNGKIAKMGEMKKAMPFAQTLKKRLQSGESPSVVLEQKLAFDEKETLAQMLPGLKKAAGLVECDVLVVEEGGKKGVNLVDGTGVDITAPTAENAVPGVPTFFFENVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZN8</accession>
    <name>A0A7D5UZN8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ATG2</name>
        <name evidence="14" type="ORF">G6M90_00g078190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545289.1">
        <property type="nucleotide sequence ID" value="XM_014689803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26241322"/>
    <dbReference type="KEGG" id="mbrn:26241322"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="532"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="716"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="971"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2162" mass="235296" checksum="27AEC7B091CB3A0C" modified="2021-02-10" version="1">MATLFQSFRGSGMPKRLLRYALSRLDLLDADALDMDNLDLAIGRNTVFEFRDVGIKLKKLQKLLSLPPTFGLDKAKVLLLRITIPMDFYTSPIIVQVDGVHVRLKVLGDVSKTARTLNTPTQEASVVPNTADLAQSFLETESFSERKQLEDALAAETNDLGASVTMSEDGSEDESPFFGTGQPLSLPGFLADFLQGIVDRTQISINNVVFQLDLEVPAELNSSKLEPVSFQVALGQINVEGITTDGQGGDGGTAQIVHQEGKRHVSLSSIRACLISEAGAFASLTRSPSTASPSLASSPAMTRNPPSRQATFLSQGSFHEPPMVALQESFRERLSDDDEASDSQDYPLGDSEDALAIPYDLSDTEHALDEELEDDLDKQGPLTPRASKYLDSCEFPRSSHLFHSIIESGMTSPMQPRAASDLLGPGVSAEHDNLVHAEQYHETGSSHLASSDLYSEASSSRSPLLSVSASVPDLAQSQVYTHEEAESMYMSAFSQTAGPRNILLVDEQASEVPGDMPEDTTQAQEMTVSEGLQHSQTIEAQQNVRNSHDLETRETTDVADVTPIDDVDQPAGTPIELQTEDTRPRTPAMPGAWDDSMDTLPDPLVQSADEAGEPGPVATGKKTTSDDNSTLSPSASGRASPSRSVRQPPLGPASDRCADDGNATPRGPPKLVKEIMRLHNISIYLPTQHQHIHVHVDSPESLNRLSQSLGQSSIYPQAPGAFSIHSSSSPGKCQPANKQAPDPGKTGALEITLSPIIINFDASIAFLLAVVMEKLIEAVKSDKQPSRQTSVSTRQDSKAAAMPRMQISAEEITVNFLNRLSGLINPSHPHVDFPLINVDEEVLLNMTLNNLKLSCASVSADTKVSMMASRPSLPKQGDTLTKIELEKFRFGYARGDILSFDGARQMSTSIRDSFLSTGYDIGIEILQSGDTVRTNVETLPLVIQIDLQRLDETFDWFGGLSSFLNMSASMTSSPSPTTKSIQTLSPKPRGVRFDTPIDPKDKSASAQNKINLRVGGALIELVGKDCSVAAETSALKVVSRDEGIGIGCSRLRISGPYLKHSLSDPAISAEIGGMRLEFLMAPKDTDLEKLLELIIPSKVKFDHENDEVMVDTLLRQRRKGSVLRATLDTVNVSVKNIGQLSALPALGEEIAKLAAVAKYLPEDDRPGLLTLTRVQKLSLNCELVPNIGHISCDIRGLEVGQITVPSLIAVAVHGINVRRNRNEELIGSSLLEGAPDSTTNGPVLMVRIIGDEIEPIIKLKLQDLRFEYRVATIMDFLDLGSDATPQDFEASLAASVANLGDQAHTALSGRPATPNAEKPAAPNKPTILDLALRDCVIGLNPYRLPSKMIVALTDAHVEAVLPNTGRTKVSVGVNKASILLTDDVKQIQSMGGQAESPRVRSSSPVSPQVEELCALGFVDICYISSASVVAVVIPDPESETKIEVEVRDDLLVLETCADSTQTLITLANALKPPTPPSKENKYRTKVLPVQDLLASISAEAFGRPEGEYDFDQDFAGAQEMVGSGSEDEFGSGRLLPVDSRFYGSQSAGEELFDATKSMESSQDALMEDTHEGVLLTGFSQSHSELSQSNDDLVIHDNFYDDNTPEEHAAMVWNSNNNSYDRAPANLIHASPVKVSVRDVHVIWNLFDGYDWAGTRDVIAKAVEDVELKATERQSRRSGVQVYEEETDDEETIGDFLFNSIYIEIPSNRDPRDLTRAINEGLNDNATETESVATTAMTMNTTRTARRSHPKSKRLRLHRSKHHKITFELQGVNVDMVMFPAGGVETVSSIDARVQNFDIFDHVPTSTWKKFATYDQDHGEREMGTSMIHIELLNVKPIAELAASEIVLRATVLPLRLHVDQDALDFITRFFEFKDDKVPVHASPSDVPFLQRAEVMDIPVKLDFKPKRVDYGGLRSGHTTEFMNFIVLEESRMVLRHTIIYGVAGFDRLGKTLNDIWMPDVRNNQLPGVVAGLAPVRSLVNIGSGFKDLVEIPLREYRKDGRVIRSISKGAVAFAKTTGTELVKLGAKLAVGTQYALQGAEDMLTQRGQAEGSWEDDDVDPEDKKHISLYADQPAGVLQGIRGGFRSLTRDVNLARDAIIAVPGEVMATQSASGAAKVMWKRAPTIIFRPAVGVTKAIGQTLMGATNALDQDNKRRISEKYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V006</accession>
    <name>A0A7D5V006_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-(Hydroxymethyl)glutathione dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fdh</name>
        <name evidence="4" type="ORF">G6M90_00g079210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987057.1">
        <property type="nucleotide sequence ID" value="XM_066131113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V006"/>
    <dbReference type="GeneID" id="90968011"/>
    <dbReference type="KEGG" id="mbrn:90968011"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="215" mass="23482" checksum="4A1A644AABE1D63C" modified="2021-02-10" version="1">MFGYSHLTGGFAGGQAEYVRVPFGHVNLLELPDDVPDEKDNSNTIDTGVEKGDSVAIFGAGPIVHMAGVFALDRGTKRIIFVDTEPRLSCIKSHFPREYMSRVELVDFKTVSSGIPNSKTVVSRLKEICDGRGPDVVQECPVGEYAKGWLHWLDMATGAETDTSEIVNEMIESVHSFGRCGITGVYVGYVRYFASSLFIPRLPQGSGLTDLDKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0I6</accession>
    <name>A0A7D5V0I6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">pH-response regulator protein palI/prr-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">prr-5_1</name>
        <name evidence="7" type="ORF">G6M90_00g091040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541758.1">
        <property type="nucleotide sequence ID" value="XM_014686272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0I6"/>
    <dbReference type="GeneID" id="26245621"/>
    <dbReference type="KEGG" id="mbrn:26245621"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="665" mass="70765" checksum="31A28DA5C526E3BE" modified="2021-02-10" version="1">MIRPATPLSVLLFAAFVLLLFSVISIPVTKFVPLGSFGDVKYGVFGYCQGEECTNIAIGYPRDGALTDETQKFDLPSSVRHTLSAILVIHPVAALLTLIMFCLAIAAHLHSASHSSRYLLVVSVFTLITFLVCVAGFVVDVLLFIPHLAWGTYMVLAASIVLAICTFGSFAMRRTTVSRKARQKRIAENGDMSGESYYNRDGQVKAAAIFASQPTFSAVGGGNLGTDSLPAFAVFESQSQRKDDQVSDEKIPLTQRSPVERSATTVHNDMANAREATSLANSRQSPSRDRYGNPINGPDAYGRERGGGYRGGRGGAYGRGGFDTYGIAGRGRGGGGRGGYGPLPGRGGARGRGGYGLPPRGGRGPPPMGGYANMPPSQHNQRPPENEYAPYGQTQPVQNSLDRGWNGSQPSLAADNNDLPRAESPPPLPGQVAGGSRAPDTDTTTPLSPPPPNAYGQHNLLRDSDVDVAGMVGLQQGRPMLGGGRETIMSDGSKYSTDEPQQYVPPRAAWNQNPGRNSPGAPSPGGQNMLPTTTGSRSDYYEDTNPRFDTTPPSGPVQSHHPSAYPEPLFEDAPATGGRARSPAESERSNFTSISQRGVNPRWEPHPPMPNQAPPNRRPVQVKHQRQDVLLNNNPDFQLPSSRGPGPNRTGTGMIPGSAYPGGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0P9</accession>
    <name>A0A7D5V0P9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g084970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541057.1">
        <property type="nucleotide sequence ID" value="XM_014685571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0P9"/>
    <dbReference type="GeneID" id="26246046"/>
    <dbReference type="KEGG" id="mbrn:26246046"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040746">
        <property type="entry name" value="THO1_MOS11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18592">
        <property type="entry name" value="Tho1_MOS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="242" mass="26032" checksum="B6B90727C3222A97" modified="2021-02-10" version="1">MTDYNALKVPELKAILGQRKLPQTGNKQALIARLQEDDDKAAAGSEEAKPEAAKQDEISYSDDEPAASKPAAAAEPKPEEPAKEEVPKEEVPAPADADADAAAAAEKTDAAEPAEPAQSYAIGLASTAADEEAKKRAERAKRFGIEEDEDAKRRADRAKRFGLDQNELSSSLDSALPERRLKRGRGRDGDNRPAKRQSLDGRGRPGRGPRQGGNKERGERAVLDDAVERTKAEKRAARFAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V196</accession>
    <name>A0A7D5V196_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Usp34</name>
        <name evidence="3" type="ORF">G6M90_00g087620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542353.1">
        <property type="nucleotide sequence ID" value="XM_014686867.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26244867"/>
    <dbReference type="KEGG" id="mbrn:26244867"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1672"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2193"/>
            <end position="2216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2206"/>
            <end position="2215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2648" mass="296319" checksum="6DF603CB9AACBF4D" modified="2021-02-10" version="1">MDNDTDSQTDQPASPTGNVAATASPNDPDHSHAPSPDPPSTRPNPFDDSDLSARKRRRTSGSASPPPSASASASASVSASASASPDASTSGKISADDKSAVKRSSTSTMIMGQQYKNTGTPSAEKIELPCTPRTPTDSAKSSSPTPLSSSKVTINLRKVADPATDSAETFLPSLSNDEALPVISNVTGDGQQKMTVEESQRARSGEETAQMSDSASPPVELIAISDDENEESDDEMAFSVDEKATGILSRELVPLDPTPQFPYIQRNEEPSLPLLRFIHHFKADSPINPEALILLQAWIQDYLKFARNAEKSTVLDSRQANKRFWLMFPEAMLQLLLRSSELVRSSELRSTIIGVYSTFACLTARMVALDILVLQEMQSTIGVTNQEPPDLYSAKYLQQLHDIIVTDVSSTNTGEERSLGSEWVQNEVGSFLLTKLQSSQGGSVSAFAHLAAALTALVPKFPRLLEHLAAIAKILSSCLRESVRTLVTGGDRIAQAQSQLEIGTTIWDNISTCLEKVIEKHVTQLGVETATTLIQALTDVLKWTLRGEHSSAFDTARQHLQKYPDLPYVNGFEAVAWQWRLGILDRLIRSSQMQLRVMAITRLCNDLVSVWKSTIDAGDESSNRFLAFIGECLLETRLIDYILGPNCHPEIIVESSNVLGFLIVTKLYKQHHTDRLWQSLMLCQDPRITEALARMVISITNLFDYDGLLGWCQKFQTMPLEAFSPAIRTLWENVMNDLISKCQSERQTPSFEPLDLCLRLLREASVCTAGSRVADPDLQLVAIQKLRELLSTARPDDLDILYLSCLDDIAKKSPTALGSLWCLSMSMRGNIPNEVENLTKNHDLARLLVEELAHAVHAGQQAGAFAVISGAPNGPRRDLIASIIQFQPAALNNGLGAILLDIIVGPKSPCLDDRKAGWYVITNVMRKVSMKNAFLQACFSRYLPGLPASCFSDGMLDFVRERVLCLAVDGSNFALDDAEALSHSGIEQLWRIILEAEDPLLVSRAISTLAVDLYLESNAIKSYSVCRSRKVHISLVNRCLNQMKQAAKKLNGSTESVIGDDDESMVIVATTEEIQLQERVFRRSLQLMRFFLEKYQVHGRFSVADFRPLMLTTVEEIQGESACLQYQAFDNFNRSDIKPLSIGLGNSIASLLTCLKNSTGFDNYRIYYRGQPLLPKEHQTTKSLEELGIRDGFILVKQEEGSASLAGYIRPGSSPLEIEILGHFQDLWEYLSMGEKLAEEVYDFLVKLPADGHFMLQFESDQHDHSKVFLKGQAFQTLYGLHALIDYIEAAQHSAFTTSHDEDSVGATLTSYQKALVRGLRLIVKAIGDPETLDEMPAVQQLRIGAAILQVFVKLFTEATRYKTLLELGDDVLPHPTRLVDILTKVEGDTGDTSLALIESACTAVLRVGSVNQEFWNTVVTSTTFLDIMKNFLLKDTRKAVRQTIVELIEDITGPQTQLLTPESGHSVYGNQEIRPVLLSICTALIEGLPLCLIHQSQPEEYFRALLHLVARASTMTSQALDIDLLAAVARDLLLKHTCIETIDRPDVADPIAAGLVAVLHICVQNSQSLSTSKNFDENTISRLFWRHLFPRKRRGDKDCVPQVILNSSTRRKLYDIVFRCVRCDINSFVHMLNTLNGLVPFYVEEPDDPYLYDLPYQFDRSRAIRAPCGYVGLRNLSNTCYLNSLLTQLFMNTQFRRFIMSVAVQDPQASQQLLFYTQKLFGYMQESYQRFVDPFDVVTSIRTYDDTPIDIHNQMDVDEFYNLLFDRWEGQLLNKDDKKQLRSFFGGQLVQQVKSKECQHISERLEPFSAIQCDIKGKATLEESLQAYVDGEVMEGENKYKCSTCDRHVDAVKRACLKDVPDHLIFHLKRFDFNLRTLQRRKINDYFTFPQTLDLAPYTVEYLNAEEGATRSDIFELVGILVHSGTAESGHYYSYIRERGAFGRSSWVEFNDDSVLPWDPSLMESATFGGPDPQSSLHDMNGIIYDKTYSAYMLFYQRASSLYHDSLSGNATINGRPPSVEVPAPLKEHILNENKVLLRRQCLFDPGHSVFVQQCFGHSIYLGESQAAKSRASKNDVENDELGRHAGPDLDTSTHTLQNLAMEVSLSHFDQVVSRTKDSILMESFASMLKSAVTKCYDCALAFYNYFHVRHGAFRSLVQRNPDPDIRSFTGKTLVLAASKIRSGLPRLYHCPVPTRSNSSPASMDSEDDWDDSEPPPSVLQGIMSIFNHLWRFFYVHIRSWDEYFGTVLAFARLGELEVGHLLADNYLLKLLHIINADPSMELQPNYQRMVNNLMRRFNSKPASYTAILALIDYLMAQLEPKLSADVIVDEAEDRRNARKPFPWTSEEVQAVHNHPDSPATSFFTEKLLETDQAPEPTNSIIGRLVESGEELDLRVFNTLRKKIQGETTTQPMDSSIRAAGRYAECSESLERVHILIRHICTQARSLQHNEGSTFLGFVDLMLRSCRPNESLALARRSYIIQAIPMWAPYLLVYGDEHTRGVTERLINDRLFSPVGLNVLDGQDDNAALEPETLEHVIRQLGIKCLMYLRDVHVRGRIQLERNAAGNILRVIGYCVPFYEGSDEMNDYADDSAEFRAIQGEITSPLQRLLVDEIEDDGSEWDGSCGSSEFMDANIGALAQTGHYLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V247</accession>
    <name>A0A7D5V247_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">vma-8</name>
        <name evidence="14" type="ORF">G6M90_00g072950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545767.2">
        <property type="nucleotide sequence ID" value="XM_014690281.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V247"/>
    <dbReference type="GeneID" id="26241800"/>
    <dbReference type="KEGG" id="mbrn:26241800"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="260" mass="28909" checksum="CF385ED74C8E2D4F" modified="2021-02-10" version="1">MSGASDREAVFPTRQSLGIMKAKLKGAETGHSLLKRKSEALTKRFREITKRIDEAKRKMGRVMQIAAFSLAEVTYAVGGDIGYQVQESAKSARFRVRTKQDNVSGVLLPAFESYMTEGNNDFGLTGLGKGGQQVQRCRETYARAVEALVELASLQTAFVILDEVIKVVNRRVNAIEHVIIPRTENTIKYINSELDELDREEFYRLKKVANKKQRDTAAADAEMKAKRQASSSREVGDKIESDATGPTDILAGEDEDDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V265</accession>
    <name>A0A7D5V265_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein transport protein sec39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sec39</name>
        <name evidence="6" type="ORF">G6M90_00g088690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542246.2">
        <property type="nucleotide sequence ID" value="XM_014686760.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V265"/>
    <dbReference type="GeneID" id="26244760"/>
    <dbReference type="KEGG" id="mbrn:26244760"/>
    <dbReference type="OrthoDB" id="3434013at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="5">
        <location>
            <begin position="3"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="573" mass="63315" checksum="EB6FC54C9BF2CFA6" modified="2021-02-10" version="1">MSLEETMKVLPGLSSTDIAVFHNDRVATYMRNDLLGQNNPLTRPSEGATNLLLALTRSAYVLTLFGSPSSPRCVGDLTFLHDERDQRSEISKLLRTIAIQASKENDDFLLKAREFLLWLRDWGHGTAGKPTAGAATVGALGMLSKEYVEAEFLKLLLSRERYSLARNLYDGGGPVRLPVEVVQDSVYESALSAFDNATNPNRSRGGLKRCDEIIHALPKTVGLSLPGTKRIIALLKATHALSDYRLVLKQGEPFSPVVLRVHSDPIFIIEKVLEQNPRAYTRLQEFLEMGMNMVRAGLPSYRKLDSPTLLTTDSELNLAAYIAERRITAMCIEAALKEDDFETAYSYVASRLSMQSPENSDTSPWPVVDEWSWKAALQAGQYIRTERSQQPTHLGTASGNLEIRHLEQRIECLATALRVAPTSQLQEILKSFRRCEEQLDSAIKEEAANELALGEEAKVDNLPGAFDQVNVEQQYPVRNTTASVAAQQTEEAPMSLFDLSRATARAAQRNFTAIPSLQSITRGADANNNEHEGGSLSRIRKRDQLREAATGTLVSGVGWLIGANVGQNKEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2B4</accession>
    <name>A0A7D5V2B4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g100030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546346.1">
        <property type="nucleotide sequence ID" value="XM_014690860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2B4"/>
    <dbReference type="GeneID" id="26240769"/>
    <dbReference type="KEGG" id="mbrn:26240769"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="307" mass="34587" checksum="37AD1BD4B0516F40" modified="2021-02-10" version="1">MASKRRLSAPVAPTPAPSSTVLSSPESILVDSTCTSSSSNAVLDAKLLDRAEKLARMTMELKIHKVVMQANDLARGLEDLTRKTVHNESFRQQNEERMEKVWQDVLSVKANFEQHLDARARDELHLGECQREVVEVKSSMGEVRKLVEELASKVDQLPTLAEANAVLAGVCAQREACESAAAVCRERCELGVRAGCSHKPIQTRIQEAIKSTRRWHHDHKSTALPDAVFTANYLKKQSKRDPRMAVYLQRAIHKRIRRRRRRESGPQPQSLEEFCQDVSWEDVTRTVEDVLVRRVDSTVQSLSQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2D9</accession>
    <name>A0A7D5V2D9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATPase complex subunit ATP10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ATP10</name>
        <name evidence="2" type="ORF">G6M90_00g100220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546327.1">
        <property type="nucleotide sequence ID" value="XM_014690841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2D9"/>
    <dbReference type="GeneID" id="26240750"/>
    <dbReference type="KEGG" id="mbrn:26240750"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="350" mass="39212" checksum="5B12D8B5B1D0ECD6" modified="2021-02-10" version="1">MSSPRLGLAVASFASRQSLSSPLATCVYCQWRRGFTASALQARTEPPASGTSMDPKSHIPGTPIEAPRSYGKRVDENFTPKPLPRPIGMPLPPRPGENTGIDTRSLKQRKEDFGDYEKHIARRKELTAKISRPYFRDWGNLQFHKGKSFIAPPRLFKAELSLFFPNLYGETLVKTDKTPRDTTPLLTGKASVVSIYSSQWAEQQAATFVSKESNPALHDVLDKNGDLAQMININYEDNKGKAWLVKLFRGSLRKRFAEKDWDKYFLVQRGITDDIRESIGLLNSKVGYTYLVDHHCRIRWAGSGLSHPEENASLAKGLARLVEEIKRDAARPAAAREPLPGKPHIEKQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2J7</accession>
    <name>A0A7D5V2J7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">chitinase</fullName>
            <ecNumber evidence="1">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g095270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546803.1">
        <property type="nucleotide sequence ID" value="XM_014691317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2J7"/>
    <dbReference type="GeneID" id="26241226"/>
    <dbReference type="KEGG" id="mbrn:26241226"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF378">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="11"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI73536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="380" mass="42948" checksum="27FD63E490A506F9" modified="2021-02-10" version="1">MASSTHRPFATRCVMYLTGQHNVVPSEPELTEQITHVILAFMRSDVFNSDQQSPEFPLFTTVGEVREKFHHETKVMVAIGGWGDSKGFEEANKDAKSRKRWCENVKKMIDLTGADGVDIDWEYPGGNRDDYKIIPNERRKWEIEALVQLLTDLRVSIGSDKLLSIAVPGLERDMMAFTEETVPRIVKQVDFINVMTYDLLNRRDTLVKHHSGVSASLESIESYIARGASAPVLNLGLAYYVKWAMAEECDPSHPLSCPTQLLEDPETGADLGRTAAFSWHDKIPEELEQSFSRAMTNGKYFEDGSFGYLDVKEARWWTFDTPNVIHRKFKDIVKQRRLGGVFAWGIGEDAPAFSHLSATLHELQNLTKDDMGEAASKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2U0</accession>
    <name>A0A7D5V2U0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">crnA</name>
        <name evidence="11" type="ORF">G6M90_00g102410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546105.1">
        <property type="nucleotide sequence ID" value="XM_014690619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2U0"/>
    <dbReference type="GeneID" id="26240528"/>
    <dbReference type="KEGG" id="mbrn:26240528"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="36"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI72897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="514" mass="55008" checksum="1674F932FCCE0462" modified="2021-02-10" version="1">MGFNISLLWKTPVVNPINKKARSIPVLNVVDPYGRVFFFSWMGFMLGFWAWYTFPPLLTVTIKKDLHLSAAEVGNSNIVSLCATLLLRFVAGPLCDQFGSRRVYASLLLLGCLPIGLAPLVKTANGLYVSRFFIGILGATFVPCQVWCTGFFDKNIVGTANALSGGWGNAGGGITYFIMPAVFDSLVASQGMTPSKAWRVTFVVPLICLIACALGMIFLCPDTPLGSWEERSQKLQENLDQYSPTSTTAVNTPHILSEPPSRDEEKAEGSDGESKFYRQPSAISLSEAVSIAQAETVVKPSFKDSLPVILSLQTLFHVATYSCSFGGELAVNSILSSYYKANFPHLDQTKASNYAAIFGFLNFVTRPLGGIVADILYKVSGQNLWTKKAWITMAGLLSGALLIVVGKVDPSEANGRDIGTMVGLVTIAAFFIEAGNGANFALVPHVHPAANGVLSGCTGGGGNLGGVVFAIIFRFIDHGSGYATACWVIGVIHIAVNLAVCWIPPLPKRQVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2X6</accession>
    <name>A0A7D5V2X6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response regulator mcs4</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="primary">mcs4</name>
        <name evidence="7" type="ORF">G6M90_00g083200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
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        <text evidence="3">Belongs to the SSK1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
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        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="695"/>
            <end position="845"/>
        </location>
    </feature>
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            <begin position="1"/>
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    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="9"/>
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        </location>
    </feature>
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            <begin position="20"/>
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            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="744"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00093463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI72159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="895" mass="96323" checksum="E4D2796B8DE5CB0C" modified="2021-02-10" version="1">MAHDIASRIKARLSRRRHSTTSSLASSRSGLGEASVSSVPSQTSREASCASHAQRTASQTSDEHPEAIGHGAAAGNQDENGDAEGDKRQHRDKDQDGGAGDEQGTNRASGLDSEPPAEGPFLQRFGAGNSGGAMGASEKEPLAQPGSLAEEALSRQKLEGHPLSHAPKLAPQVSQAPRNIPMGSVDMDQGQAHHDMDAFDKDPPRHDHLHGSAWAASRFGPHPDPSAQLSPATAVHLPPPPRSTPSPTSSSPLRTSRTSTLAVGDRNSPQRAGAGRIHNHGHNLRLFDIGSSGSGVRVPPAHAGDDLEVDPLQPPQHGRELDHLSFASFPAAASASAASSAASPVSFTSDPQPSRRQSLFASRQTSLIKTLLRSNQPQAAADTEHRHSIDTIMVTRKIWVRRPHASATTITINEDDLVDDVRDMILRKYANSLGRTFDSPDLVIRVHPRDQEKERALGPEEVMARTLDTYYPGGQTIDEALIIDIPRRTPKASPRVPIPPGTATTYYITEDGRPSEAGEGYFPPVVAIPSPHTSHVVPATVPNGTVPHSIAVLGTGHIPPIPSPGATSRSRLYRDRPDRPRLNRTHTSSPTLMAGHAPGPQASNTGSHGTQNFVPRLPHSRTHSSSSDHPSGLAMVKTPMAKSPGPEVTPARIATPPPRSSSPRAPSLRPKRSKKSSEHPAAAGTVLNGNVPPINVLIVEDNPINLKLLEAFVKRLKVRWQSAMNGQDAVKKWRMGGFHLVLMDIQLPVMNGLDATREIRRLERINTIGVFTSTPDNATGNSEEDIKEQDRLQNPSLFKSPVIIVALTASSLQSDRHEALAAGCNDFLTKPVNFVWLERKVMEWGCMQALIDFDAWRNWKEELSVQDAEREEAAKNALATKAKSKKNRSSLSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V330</accession>
    <name>A0A7D5V330_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g094390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540803.1">
        <property type="nucleotide sequence ID" value="XM_014685317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V330"/>
    <dbReference type="GeneID" id="26246416"/>
    <dbReference type="KEGG" id="mbrn:26246416"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="744" mass="81297" checksum="CE8B9A8DD4AB2DB4" modified="2021-02-10" version="1">MTPPVDMEDNSSPVSNQTADVEPPKRPVPPSLSSDAAPKPKRGKYTSVACNECKKKKLKCIPVNGSSCERCIAGGVHCVFAAVTPQSSKKKEESNHQMQALGDELAKLRQQVTDLSRTVDELKHQSPGARTTMAGHFDVVAARSPSNTSKDNVPKHPQFVGPTRPSYGLVIAERSLTRMGIPASPSPSPSGAPSPAEPEQAEATDVEFWAECSPEEMARLLAVFEEEVESVYPFINILELAARSEQILRVIRHPSLLDEAPRVDVHEPPLTWTDVRLAKLAVATGIAIEAHGKNDLCAAIAESVVAVTARISRTEVELKGIQLLMMLSIYYFHCDDELLAWRTIGIAAREALEMGLHRRRSLYDNFTDPQSRHAALRVFWCCYVLDRRWSFGTSLSFSLTDRDIDPALLEPDIDSSYLKCMVGYARLCSKLWDAIPPFGSACQSIPADVANALDASTQTWLESIPPHLQMRHPRAFYSTRSQPRVLHRLRAFLYLRGNLTRISIYQHHLLSAATIKADLARAKVAVDLAQDTVQVLVHLNATSDIYSRQQNAFNYFLLGAFAVISLAICHAPNVFAAGCAQSFIDAIGLVRGFSRHSIASRRLWKSIRGLLPRLKSLGLQDCDAGAGGDRMHSPSAAGTLGSDASSMSSYIVRGRPSVSRADDDQVWPANGRQTGPGALTHPGLGADIPDMTELNNDILNLFDTLGQGSQFPDDFDSGLYNALDADLVGGDGLDISRRFLQGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3B0</accession>
    <name>A0A7D5V3B0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g097360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546605.1">
        <property type="nucleotide sequence ID" value="XM_014691119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3B0"/>
    <dbReference type="GeneID" id="26241028"/>
    <dbReference type="KEGG" id="mbrn:26241028"/>
    <dbReference type="OrthoDB" id="3835793at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="34102" checksum="F5E0F828B50A3364" modified="2021-02-10" version="1">MSTTAANFILSNILGLGLVTITSPTSPVILLLVAEKGPFITYEYLLSAVDLTLALVISFLVLCNLEHKWIAKNYSFPYAFHPVRNLGAKALQFQLVLFEVYHLHLFSRITHILTLLVEEAAWLFLIQGTFGAVGLATANALLALQAFSYGDALLGAAITALNLAVSLAAAIGFQGVADGGGALGGIKIGLVLCAALRTASHVAEPLPPAYNESSKSFERSFGVSGFEFLFSNTLFAFWLFCYGVIQEMGAGMPGRLFNIAVAEVMYSAGYQGKSAWDVVVAKGWACEIVKRGWEAYPMSQELLAWVAVRDDSGYPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3C9</accession>
    <name>A0A7D5V3C9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sphingoid long chain base kinase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LCB5</name>
        <name evidence="2" type="ORF">G6M90_00g110250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987812.1">
        <property type="nucleotide sequence ID" value="XM_066131808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3C9"/>
    <dbReference type="GeneID" id="26243221"/>
    <dbReference type="KEGG" id="mbrn:26243221"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055916">
        <property type="entry name" value="DUF7493"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24321">
        <property type="entry name" value="DUF7493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="125"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="510" mass="56060" checksum="90276E7B1CE3D991" modified="2021-02-10" version="1">MENGNAPFIRDALYISMDEKKTLSLPASGNFLTVFEPISKSRLRSVCRSILTDSSGKRQVPLYNVVWIETANGNIFIDYAAQSSKTHVKLERWAFALAKDNESPGSSQPEEFAARVLERAYGDSQLRKRAYVLINPHAGPGGALRKWSNEVKPLFVAARMELDVVTLTRGGEATDLAEQVDIDKYDTIMACSGDGTPHEIFNGLARRPDAAHALAKIAVSHIPCGSGNAMSCNLYGSYRPSFAALAIIKGITTPLDLVSITQGSRRFLSFLSQSLGIVAESDLGTEHLRWMGGSRFEVGVLMRIFRRRCYPCDLAVKIEVGEKSDIKAHYKWHTNGAGAKQLPPDVVATGQVGSKGLPQLKYGTVQDQLPDDWELVQYDKIGNFYCGNMAYMAPDANFFSAAMASDGCMDLVTVNGDLSPITATKLLYSVESGKFFDNPHVQYKKISAYRIVPRNQKDGYISIDGERIPFEPFQAEIHQGLGRVISKRGAFEAAGPANWDKVTLADRMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3G3</accession>
    <name>A0A7D5V3G3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">11-oxo-beta-amyrin 30-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">C7263</name>
        <name evidence="9" type="ORF">G6M90_00g104340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541430.2">
        <property type="nucleotide sequence ID" value="XM_014685944.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3G3"/>
    <dbReference type="GeneID" id="26245680"/>
    <dbReference type="KEGG" id="mbrn:26245680"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="644" mass="72525" checksum="B1675A157E50F771" modified="2021-02-10" version="1">MQNILLVIGAALFYGVVRVILGFRRNIAIAKASNLPYLVVPRHWLVLAPIYAKLIRLLPKSWWDDWLDLMIPDAAYRLDRKRYTRHGDTFALVSPGAIMIQTSNPEVIRQIIAQRENFPKPCQIYRMLRLFGENVVTTEGCVWKAHRKATAPSFNEKNSALVFREIIEQTNGMISTWVDSFGNRSEPLTTISADITRLTINVISYVGFGLRLLWPGQVLPPGSDTAAAKYASLDPPPGYSLSFVDTLVRLLNNILIVLLFPHWMLKLSPWKGPRLAAAAYQDYVRYSNEMMNEKMEALQNGTQAEEGMDFMGALIKGSYGLDAKGTADKLGKPLVLNREEILGNAFIMFVAGHETSANTIHFTLINLATNPAAQRLIHKDIDELVGNSDPSTWDYERLIGPMTGSAIAACMNETLRLIPPGPAIPKQVSRDRDQVVNVGGKECLLPKGSMIMLQVLKAHEDPRYWPYEKSQLTPGQDDLRDYKPERWFETVPGPRCERKEADEERARSESSDGGDDESDEGIDRKPDRNARFFRPRRGAYLPFSDGARSCIGRRVAQVEIMTFLAVLFQRYSVELAPDQWASEGEVQRMGREARADVYRTAQAFSRKTLAEAESVITLGLQGKTVPMRLVKRGEEKFINWMSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3I4</accession>
    <name>A0A7D5V3I4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KTXA_1</name>
        <name evidence="18" type="ORF">G6M90_00g093700</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the secreted LysM effector family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987688.1">
        <property type="nucleotide sequence ID" value="XM_066131458.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26246350"/>
    <dbReference type="KEGG" id="mbrn:26246350"/>
    <dbReference type="OrthoDB" id="4934367at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028846691" description="chitinase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="396"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="460"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="601"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI73538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1368" mass="150564" checksum="C3F12195B7D03832" modified="2021-02-10" version="1">MKASLYQVAIPHVLFFLQAAATLQGGPPTVVRTSSAGALETLDTEGNKELEEWLAANIRTPPSMLKPCPLPCSEAPDSINGGGWFLVPDATSFAQCNKTLLLDLVVKSDDPPALRACTADYGSNYQLSKIHSPDDGNAALCSTPNHEMVKTSIRLLEVSTPTQNNDTFATQHLVSASRQVMHYLASQKPSCSKNALAFGYSQTSVVGVFAGAELHQHGLAIDVINSLLSYATERSISQTTVLQLCQEHGLGADYSFGLVATNANNLKFAQEAVRRWASGKCVGPDGGRDWKEVTIRVPSIVRPTNTTASSNMTGSRLSYRSSWQDLARVHCKTLTVRSGDGCWALAKICGVSQSDLTKYNRRANFCDTLVVGEKVCCTRGILPSSIPDSKSDGTCVTKEVKSGDSCGSLASKCGLSASDFMRLNTKEDLCSTLAEGQQVCCSRGELQDRRPKPESDGICASVKTNRGDSCASIAASRDLTVRDIESFNEDTWGWNGCKVLWVGFRLCVSEGKPPMPEPVSNAVCGPTVPGTKAPAKGFDLSRLNPCPLKACCNVWGQCGLSDDFCIESKSETGAPGTSGVRNGCISNCGRAIIRSSPPPSVIKIAYFEAWNHKRSCLWMDIDDIDTTKYSHIHFAFGEVTKDFRIDISKVQTQFYKLKAMVGVKRIISLGGWDFSALPGTYNILREAVQPRNRDKFITNIVDFLIQHDLDGVDLDWEYPGAPDIPDIPADDPQNGLNYFKLLDELKYRLSNAKSVSFAAPSSYWYLKAFPISLMAMSLDYIVFMTYDLHGQWDYGNKWTSPGCPTGNCLRSHVNMTETKDALIMITKAGVPSNKVVVGVASYGRSFKMAEAGCYGPLCKFTGTPRISHAAKGRCTDTSGYIANAEIEEILASGKVTKQWREAGSNILVYDDTEWVAYMDDKLKDIRTQFYLMNNFAGTTDWAVDLQKFLPGDGIPYDDFEDEYEPYIDPDFYSDCSGKYSTLGDVEKHLTTMPTHCTEKYIAQAESAMIKEALTKHLELLQDDYDSKFKTYERFVKQQVPVQINNFMASDKVHQYFKCSEYKKVICCSDCTYATCLETCANFAGCKSGYQTLDIKCPQQKDELDMISMETTPNATFHLKDEEGFWKEIGSQYGIEEAWVAFGRRHMRTANGCQYAGKAIHECQNQNDRWWYNYPIAADDKIKVYNPKKIFGDSTDTIASLAENLDIIKDLNIYDTLMPWSDVVDAASLPALTLQAAVDNMKSIIDKAEEIEKKQKEEFILNMVMGILFFIPVVGEAAGSAGLTAARSMLRLIGAAGDAGMTVYDIVKDPSNAFMAAFAYVLGAGVGRSGFRDAANSRRAVRPRELAAVGSLKTDLQRIQVSRKNICYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3U5</accession>
    <name>A0A7D5V3U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g107980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544046.1">
        <property type="nucleotide sequence ID" value="XM_014688560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3U5"/>
    <dbReference type="GeneID" id="26243433"/>
    <dbReference type="KEGG" id="mbrn:26243433"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="670"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="834"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI74175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="929" mass="101605" checksum="1CF18911AF338120" modified="2021-02-10" version="1">MTDPPFLLKPKRLSLVAQSPARSRAGDDIFSHLSPTTAVEALTSGNGALRGCLDGASATERDFAMRAAIASQRIWEWIDELSGWAWPLESASTGFLTPNNILPRLSFQANVPKIDGSEYVGSLHAREVALYERRIEEIHRDMDSLALEEIKSQVLTNHILPLSRPNTPLSISSKGIPLTSTYTKMEDLSAVVTTIVVQTLPKISRLNQLLRIWSSRLAVLQRVPPLLYALEDAEAGVKAGWTAISKPLRRSIQVDGRGAVVEKPKLNRSDFEVMNKVLIKKVATPGRALDYMLDTLEGMDDTIPDSWLDRMETVERSYSEWVAACERKICETEWSRSAERQKSPKSPLAQAAKEIIDCTLSESSDLPTDDSGVAIMLPVSPKHSSTSVIPVSSGVKDGVVPQTSASGGLSSHDAREPQYIEDNGPRTPSDEGSFDSELTAESSAEANQSIFVGDNDSLIEHDMSHITRTMSPVDEEEEGGSEADLPRLHKSITHHSRSLESFVMMHGDGDTSRFDLTSDLPEVSASPPVPRDRIREAQFVDDSPPSSPPLPLDDTRDSSPPNGLLDSPIITSVPEDDSSMYGKTLVEGSFVFDFDDSMSVSEAAGPTYRRDSTGDKQLRQQISDIIESIPAKIKLSAETPAVNLNPPDLQLPRIKKKSSKEMFKRSTSGLSSRTTTPSFTLSPARSTRPRPTRGQQEIKVYHLSRSNGEPPIKLFIRCVGEHGERVMVRVGGGWADLSEYLKEYASHHGRRSAGKEKAARIEVQDVPRGSTPSAMGMGSSTPDRPASAAAVLSEHSPVTPLNIRKTRRSIGAANSELPRLLPKTPAIATQPADTPSSSESTRSRPGSRLSWLEDDSSFLGLAGPTGKKVEMSEENKAWVESVKEKVRQVSVERRIPPPEERNRFGDLGRVGGTKRLFRKAAENGVQGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Z8</accession>
    <name>A0A7D5V3Z8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g099840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546365.1">
        <property type="nucleotide sequence ID" value="XM_014690879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3Z8"/>
    <dbReference type="GeneID" id="26240788"/>
    <dbReference type="KEGG" id="mbrn:26240788"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="200"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI73858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="350" mass="36995" checksum="25D0501347F844BA" modified="2021-02-10" version="1">MAQDVSLPYNICVFISTLFLLEFATDKFISHAATLASVINVSELLIGLVTAGAEWEELAVVVSSLGQGRSSLALGNVIGASISNILGAFSLGLLCSRNIEFDRGSRIYSLLTLVLTTLVVPVVHYSSRVTWIVCGSVLIVGFVVYFVSVGVAVVKGVLAAPEDSDSDDGDEDEDEDEDTERTALIGSPSPSPPRRSVAHHTLQLIFGIVALALSAYILAHSAANITTQLHMSDISFGVVILSIATTLPEKLISVVSGYRGHGQILVANCAGSNIFLLSLCCGIILISTGGELDRGTVTIGELAVLWVSTLTFTVTVWLRGRGAKAVGVVMILAYVAFIVLEYTIAHREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4D0</accession>
    <name>A0A7D5V4D0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pierisin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g111960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540268.1">
        <property type="nucleotide sequence ID" value="XM_014684782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4D0"/>
    <dbReference type="GeneID" id="26246862"/>
    <dbReference type="KEGG" id="mbrn:26246862"/>
    <dbReference type="OrthoDB" id="4868762at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054695">
        <property type="entry name" value="Pierisin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22596">
        <property type="entry name" value="Scabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028893171" description="Pierisin-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Pierisin-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="378" mass="41058" checksum="BDA3E0886711E154" modified="2021-02-10" version="1">MKAHQWLAVFALSSLAAPEHTNLLPSQSNRVRNSGGFDIDPALSNKTALGIIPDNYDAVKRRDLVLRGDILKRQAPTSPSTMSADGASQIKVSGGKQGVLYHGDSRPPAEVFKSGFTPQGGDTNLQHHLSFTGNSAFTSVTRSPQSAERYAFGWTGAQKHKGYIYVIAPKDVPRGYWVPGIYPSDRVVINNQEFAVQGAVTGSSIVHAYEVPKRNPSDRSVTIKNENYVLKKSPGCLGLKSKPALCDPAKGENGRSGPKVSKSSRFRVAKSVGKSVAFMAVVPYARDLLNLLKQWDNPIGHAVKWFDDAITSLEEVIGGPQRKDIYGNELQGRIIDALKSISLDSVSGGTPCPCSEWTSTKALSSWRALLRARTTPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4T8</accession>
    <name>A0A7D5V4T8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metal tolerance protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MTP7</name>
        <name evidence="9" type="ORF">G6M90_00g098530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546491.1">
        <property type="nucleotide sequence ID" value="XM_014691005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4T8"/>
    <dbReference type="GeneID" id="26240914"/>
    <dbReference type="KEGG" id="mbrn:26240914"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000004">
        <property type="entry name" value="Cation diffusion facilitator 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF4">
        <property type="entry name" value="CDF DIVALENT METAL CATION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="8">
        <location>
            <begin position="305"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI73591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="595" mass="66418" checksum="14AC0D7E5EF11D88" modified="2021-02-10" version="1">MSSPNHRSSPVRRPSLLSLDDNHHHYPLATRTGTLASLIRSRSQQSLAGSWPPPLHRHGTDDEEAGLWMRHDEDDAIERLLKDENRLSQILKGPLARSMNLIGKSNPRYRWERYWKHDDELQTMKKPIREYYERTNELIEQYMYIDCLLDSSIPHDLLNEYNAELEASAFKPIDVPATITEEPGTSQSLSASLSASLAAEMEQLAQTTGSYGTVNGNANANANSSPVDEFSKQVALPQKRTPKDIFRSSENLPLLKHSHDDSEEEDHTAQPALPSSSSDSGPRPNLPWLEDAEIDSDDPIVTLAIWVNMIANIILLVGKVAVIISVPSMSVLASLVDAVLDFLSTAIVWTTTRLISAGQQDQHHYPVGRRRLEPVGVLVFSVIMVTSFVQVGLECIQRLAKPEHEILQLGLPAIIIMFSTIVIKGGCWVWCRLVKNSSVRALADDAKTDVIFNVGSIFFPIVGFYGRIWWLDAAGGLLLSLVVILTWSQTSAHHVRNLTGLSAQPDERNLLLYLTMRFATAIRQIQNLRAYHAGDKLFVEVDIVLSAVTPLKDSHDLSEVLTYFLESVPIVDRAFVHVDYTSYNAPTHMQKQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5J4</accession>
    <name>A0A7D5V5J4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g094260</name>
    </gene>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
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    </dbReference>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKU8</accession>
    <name>A0A7D5YKU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g020870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="26237903"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
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    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
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    </dbReference>
    <dbReference type="Pfam" id="PF00646">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="380" mass="43224" checksum="AB0BC1B5DC6B2914" modified="2021-02-10" version="1">MSHVGYSVSNQDVHMADSEDSMLDELLLEKLSYRYLSNIEQYVSRWSKDIEIKEPRMDYDPKTPIGHLEKLPIELLHNVFEMLDFQSLLRFSGACGRASILVQTSPVYRDLIEYAHRGLAALAFSGLIGHHPAGALRAALRSQNCFSCGHYGQLLFLPSCQRCCRICASRNQSLWVLPRGVAAKCFRIPLRQVDQLPGILRLPMYPQGRFATPKPESFVSVACAKRLALAIHGSEEKITDLPFSTRLSDTKRELYAHYRAAQLRPYTTDPLISTTLNEFEDPHESYAHIYLPSITSGVVYHGFLCRGCLWMCQNYHPKRDKSTSLVPMERGPPDLILRARSREGFLRHIRMCFGVRQIVVTNGLEHWGQEIAHIPINQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPW5</accession>
    <name>A0A7D5YPW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g028560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014685823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPW5"/>
    <dbReference type="GeneID" id="26245944"/>
    <dbReference type="KEGG" id="mbrn:26245944"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="60"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="845" mass="89975" checksum="5E5B70C2420C46DB" modified="2021-02-10" version="1">MERKRKLPPRAAARQEQAAKKRNVTTRQSSTPAVAEPPPREPTPSPPPPPPPPLPKSIEVGKPLPTVEEPQPTNLSCKEYQSVSESGVMSESLSRSRHKWISEGLFEKFWSKPHKRKGVLQEDPNNPPKDSMMKVGLVTLTIEPHIVEATMYAVKTSKLLPHQQQRFKPNPQPPGQATPTGQPQQPTVVQPQPQQQQQQPHPNPSAPAQQPVLARPVLQYGPPNGAMRPPPIPTSPVTTTPTSMATPAASTPGATPAGAVPVSTYSTSAAPTSAAPVSPKSSSPALPAVPPASSPAEMHVKATSSPNPGPPSVAQPAQPSAPQQGQPQAQSQGVVASTPTPTPAPKASQHSSPPPNTAPLASGAHPPSSTIQTPLQPAGASQLITRPVANAPPRQAVVSSPAAGPSSSTASRPAGTPNQAQPPAPSNRPPPAAPRAAPAPAAKPAANDPVIALLAQKASADPELRDLMKRVAVGQAKDGELAKFQKIIDQLNAEYRQRGGQQGPSADRLLVDGRTVKYFADEVRTILDIVLASNPNQKSSELRPPPRSDPLVVLLVKTALENQRIKDMIRRIAEGKPGFTDATDLKQTLDRLHRDAKITPKATTTPGPSPLRQPPVNGSPAASQPKTQAPQGAQQANQQIKSKASSHVNRPDLSAVVFDFGSGDRCLFPRYSILEFLPSQSGQHVVASFLIVRKGSASEYGGDPKLDYYQPVTIRLQTTTGRHLENLARVVAPQDEVRRYMDDVMDNMTRAEYVLLAMRLPRVDFDPQEAVPVVEDSKASSPTPKSEPETDNNTTPKPGVLWTTGSSNKATVSALPVKLQDPEQEAQSKYERLIRSVAEKEVDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQK2</accession>
    <name>A0A7D5YQK2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxygen-dependent choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">betA_1</name>
        <name evidence="5" type="ORF">G6M90_00g028840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541283.1">
        <property type="nucleotide sequence ID" value="XM_014685797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQK2"/>
    <dbReference type="GeneID" id="26245918"/>
    <dbReference type="KEGG" id="mbrn:26245918"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF100">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028842672" evidence="3">
        <location>
            <begin position="24"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI66121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="647" mass="69414" checksum="FCD157DA4BB55242" modified="2021-02-10" version="1">MMMRSSWQAALAGLSLLSSLAAAANLTGYEYVVVGSGAGGGPLAARLALAGHKTLLIEAGDDQGNNPNYTVPAYSARSSEDEKLAWNFYVRHYADDARQARDYKTSYRTADGTLYTGLNPPPGAEMLGTLYPRTGTLGGCTAHNALVAIYPHRSDFEYVASLTGDASWAPDNMRKYFVRMEKNRYLLPLLAKGHGFDGWLDTERAPITLPLEDPKLLSLIAGGSFALGNYSRLLPNLLDVALGDANEDSESRDRDGGYFQIPLSAGDGRRYGSREFVVATRDAKNPDGSKKYPLDVRMNCHVTRVVFDESGGGEPRATGVEFLDGAYLYRASPRSGSAAKGVPGSATASREVIIAGGAYNSPQLLKLSGVGPASELAQFGIPLVKDLPGVGTNLQDHYEVAVQGRLPSDWRFLSGCTFSDDNDPCLDRWRRPGLLTGRGAYVSNGFAAAMLMKSSVASEYDAFLFGGPVNFRGYFPGYSYNITADHDVFTWAILKGHPRNTAGHVRLRSADPLDVPDVLYNYFDTGSGDSAADLTAIREAIGVARDAFSRQLVKVDEVLPGAGVRSAAEVEAYARDTAWGHHASSTCPIGADGDPMAVLDSSFRVRGVKGLRVVDASVYPRIPGTFTALSTYMVGEKAADVILSQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQT9</accession>
    <name>A0A7D5YQT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ESD</name>
        <name evidence="8" type="ORF">G6M90_00g018540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548686.1">
        <property type="nucleotide sequence ID" value="XM_014693200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQT9"/>
    <dbReference type="GeneID" id="26238130"/>
    <dbReference type="KEGG" id="mbrn:26238130"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="31176" checksum="F58D9F2B9FD80420" modified="2021-02-10" version="1">MAFTTNATIASFNGRILKLTHQSSSTSTPMNLNLFLPNTASSSKPAPLLIYLSGLTCTPDNVTEKGFLHAHASPLNLALLYPDTSPRGTNLPGEHDAYDFGSAASFYIDATKDPWDTNYRMESYLTTELPELLFANFKELDAQRVSITGHSMGGHGALTLFLKNPGKYKSVSAFAPICNPSQCPWGQKAFAGYLGDDKAEWAKHDATELVRRWKGNLNCLIDVGTGDNFYNSGQLLPENFVEAVKGAGVDGVNVRYHKAYDHSYFFISTFAEDHVRHAAKALGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQX6</accession>
    <name>A0A7D5YQX6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="56"/>
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            <begin position="1"/>
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    </feature>
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        <source>
            <dbReference type="EMBL" id="QLI66162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI66602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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                <person name="Kortsinoglou A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 7">4556</strain>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI67882.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
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    </evidence>
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</entry>
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    <accession>A0A7D5YT93</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <lineage>
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                <person name="Kortsinoglou A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">4556</strain>
        </source>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI68682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A7D5YTI6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g020130</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF8212"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
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        </location>
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        <location>
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    </feature>
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        <location>
            <begin position="80"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="167" mass="17841" checksum="33BE9B8B10C24C4B" modified="2021-02-10" version="1">MPMPYGERQRVFYRLREEVTRKYNDLSIFAWTGPATTTLSLPRRPASSRTTAKSVARHTPATSTSAAVSTPNSRSQTKASSSLRLSSTRSINCPFPPTNTSSTSANTTAPIPTTTPSPTSVACYSKKSARASLCASKKRPTARPPSEDGPPSIPAGSQLHLLYPSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTS7</accession>
    <name>A0A7D5YTS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">La</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sla1_0</name>
        <name evidence="8" type="ORF">G6M90_00g007330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549777.1">
        <property type="nucleotide sequence ID" value="XM_014694291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTS7"/>
    <dbReference type="GeneID" id="26239221"/>
    <dbReference type="KEGG" id="mbrn:26239221"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="73"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI63565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="392" mass="43553" checksum="F84AB5F43D314D7E" modified="2021-02-10" version="1">MSEVDAGTKPVEAPPVEAPSVEAPPVEAPPVEQQQETSADAAASAAEDDSMIKTTAQTDHKDVKKNNKFDPSVREVTDDPEAIRKQVEFYFGDWNFPQDKFMWETCGGSENKPMPITKIHSFKRMRTFQPYSAVVAALRDSKFLEVSGEEGAEVVKRKTPYKPMPEGKAKAEAATVYVKGFGDESPDTQFDLESFFAQFGEVKGLKLRRTNENLFKGSVFVTFMDEDAAKKFLATEPKPTWKGHELKMMTKKAYCDEKSDLIRQGKIEPSSSGPRKFYEGKDNKARPAKKGGRDQDDWKKRRDHDQKSGFRDGRGGRGRGGRGGRGRGGFGRGGRDGGRRDKDQVKDAMYSESAPEKKEEKESNGKRAREEDAAGGEEPAAKKVDTKETTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTX6</accession>
    <name>A0A7D5YTX6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985638.1">
        <property type="nucleotide sequence ID" value="XM_066129968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTX6"/>
    <dbReference type="GeneID" id="90967534"/>
    <dbReference type="KEGG" id="mbrn:90967534"/>
    <dbReference type="OrthoDB" id="4829551at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="243" mass="27441" checksum="85B19EE687CE5B2F" modified="2021-02-10" version="1">MAQCQNVSEKGSTRPPLKRTRRQPWKENDEKYPARASKRNSKSRNVDLRQSPRSDDLRGGSQPMVEHASTHTRFSRSWDGDDFAYMSESECNWSNASTVCSTEDHNAASPFTRGRWRSTCPELGCSGTPSDSKPTMRPESDLRHTGAWIECEIVLLGDKHLLFDDESLENHPPGLDAPDLGNLATPHLSPMPSTFEFCYCCDDDQDADRGGRVNKSLRLCCGDKSDARLEWALGYLEQKRRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YX48</accession>
    <name>A0A7D5YX48_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid amide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAAH</name>
        <name evidence="3" type="ORF">G6M90_00g091200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541772.2">
        <property type="nucleotide sequence ID" value="XM_014686286.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YX48"/>
    <dbReference type="GeneID" id="26245635"/>
    <dbReference type="KEGG" id="mbrn:26245635"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="611" mass="66240" checksum="4566346797919B40" modified="2021-02-10" version="1">MVSPNDFVNYPKPVEGPETKYAPPPAKNPVLRGYSLVAASALSGILQRFFWNNAGFGQVKNLSVLDGVPHTFDPCVTPLGETGPVLEFEPALLEAKHVHPKAKYYSIKDYHELYKSGRATPLDVAKALLPLTKPGNDNKTRYEDAWANNHGNDELVFESARASTERWAAGKPLGILDGVPIGVKDDVNVKGYVNHNGMKYNADSPFFKRQEKSAWCVQALQDAGAVVLGKNRMHELGSDTCGLNVAQGSPTNHLNTEYYPGGSSSGPASAVCAGVVPFSVATDAGGSIRIPASFNGLYGLKTSHHRTGYMGSTMCITGPIAANVADLTIAYRLMSQPNPDDGIQGVFGRSTPPPPSAKRVMGVYREWLNAADPEVIEHCNKALDYFAKERGYEIVDISLPHLADAQLAHGMICITEMAEAARRRTVNPADWLSLVGSVNRLLMTVGQQTPAADFLKFNTMRTVLMRHFAFLFRKYPGILIMSPTTPLNGWPKHPGDEALGMNDANTTFRNMMYIFLANMTGTPSVSVPVGYAAPKQGEGKIPVGLMATGEWGSEEQLLAFAGEAEEYLHGIYEEGRRRPSAWLDVMALVEGDADSEKVDANGNGRSDHILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXC2</accession>
    <name>A0A7D5YXC2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g032740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI68384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687719.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244006"/>
    <dbReference type="KEGG" id="mbrn:26244006"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
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        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="117"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="209"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="291" mass="32959" checksum="65F088B0BBA8F10E" modified="2021-02-10" version="1">MAIVEGWYPPTRENWQTTVLIFQILYPALSLMQLFISWYGMGKTSVRSAFNLPGRVAWVLMEMPGFTTVLYMMKTLPRMHGIDDLPWQNRVLAGLFVIHYIYRAVVFPLIQPSMSPIHVLVALMAAGFQVLNGVGIGAWLAAYGPVTAEAWAARSSVAQFCVGIAIFYVGLAANFFHDEELREIRRAEKRRRQRVLDKQGGAGGAASVEKHYQIPQAGLFKHVLYAHYLCEWVEWFGFLVAAGWGCVPAWTFLVNEVFAMLPRAVKGKKWYVEKFGEDKIRKRWAVLPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXH6</accession>
    <name>A0A7D5YXH6_9HYPO</name>
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        <submittedName>
            <fullName evidence="8">Ribonucleases P/MRP protein subunit POP1</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="8" type="ORF">G6M90_00g090610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686233.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245582"/>
    <dbReference type="KEGG" id="mbrn:26245582"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="551"/>
            <end position="655"/>
        </location>
    </feature>
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        <location>
            <begin position="736"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
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            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="667"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
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            <end position="122"/>
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            <end position="147"/>
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            <end position="199"/>
        </location>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY51</accession>
    <name>A0A7D5YY51_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY51"/>
    <dbReference type="GeneID" id="26243735"/>
    <dbReference type="KEGG" id="mbrn:26243735"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI72641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="326" mass="35724" checksum="E3D6501E15E38DDD" modified="2021-02-10" version="1">MPLPLKVRLAIRQAWDDPSSPSQKALQALSDTLGRPIACDPDWDVLHAVLSPLYASDAAQLVSDTTGYIQSWARAAHDVLQDDDALADNLLEAMAQRGARTLPLAIQVSPSDPQTRWDSQRAGFELLVPREPRQHPTTAAVPAFRAQITSALHAKTPPDAADGDEWADLAVPAAAATVPVSPGLDDTEPAYLPDVNTLPRPDELLLRPPYHLHIAQASAITVQCSHSPSLSFLEAYFKKWCRTNNQLTNRPPMVYVTLSQSPFGLGPLYDTLTLEVPRDHHRASGLPPQLSIPIVLHLVESVLGYTRVFSDASGWQYRRDTPLRSI</sequence>
</entry>
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    <accession>A0A7D5YYN4</accession>
    <name>A0A7D5YYN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g100390</name>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014690825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYN4"/>
    <dbReference type="GeneID" id="26240734"/>
    <dbReference type="KEGG" id="mbrn:26240734"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
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        <location>
            <begin position="448"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="642"/>
        </location>
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        <location>
            <begin position="661"/>
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        </location>
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        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
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        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="502"/>
        </location>
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        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="734" mass="79294" checksum="5E4239ABF13B1257" modified="2021-02-10" version="1">MADHTGQKMTGPASPVVVSSASSISTGPLPSPGASRRNSPSDQNTNATQADPSMSTQLAHPPPAAPATPLTPATPIASGAASALGQHSNAAAQMHPSVQTVHLRPQMPSSTMAQVHRPPINGFGPPPMQPQQGQRQRVAYPSPRVNDTQLCNSAQYVALIQLMQRTEPHVLRQVIRDYHETCLLGSEYHLAFIFNTAIHKAHKPTLTQAIADFGSRLVQTSKHQLISHFTAEDLDEVAEEILSKASTNFLDQALARRLETIRARSLVNALAQAERLGYDVKDAVEERKDGTEHVIPYMKHDLAQHPSQHEQPRAQPHPQSFVQPSIQSVQIHSMPAMPASTWPGPQPQATQRPTNRHSYSTLTQCGVCRRPLSGPDALEFHKLKQVCYGNFRTIDRVGREICPHCGSHFSTGGLPYHIKTQACGKYTERDASALMPSLRNFYQEHISAGPSGAVQGPRSTPSSTPDQSWRQPAQSSAPATHFTAVNSGTAATMTPRSASATGKGSGPYAHLSPEDRDRLKAELTHTEVHYGALLRKAMQLPQPQQDEEVAKIKNCFNTKQSTTRRKYGVKLRERRTKAEIEAERERLITAPPEENLGRRQDASASQNGSEPVGKKARINERGDSAPTSQPAVSSPVTESPRKRVRLADMGGLGASAATAEHIDPTTAAAQDHSASQPQPAKESPGSNVVGATPDAPASTGARNDPMKLDDSTDTEDSDSEEEDGDIPAVLTEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYQ9</accession>
    <name>A0A7D5YYQ9_9HYPO</name>
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        <submittedName>
            <fullName evidence="11">Transcriptional activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">acu-15_0</name>
        <name evidence="11" type="ORF">G6M90_00g011040</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="QLI64547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014693931.1"/>
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    <dbReference type="OrthoDB" id="1924787at2759"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="ZIP_Cat8"/>
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        <property type="entry name" value="AtrR-like"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
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        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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            <begin position="23"/>
            <end position="53"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64547.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="862" mass="95609" checksum="9C2A00AEE60A9185" modified="2021-02-10" version="1">MPGILPMKVIKVGNSAQSRIAQACDRCRSKKIRCDGVRPTCSQCANVGFECRTSDKLSRRAFPRGYTESLEERVRQLETEVRELKDLLDEKDEKIDMLSAMHANHHRQPSLTSASNTLPSPDTSKDSPASTAKEDTFRVQGSPLLFGVEHSDSYFMGPSSGRSFITSFKHKLRQRGKLCNDFNPEAFLHVQGCAPLTQEEPSQVSRLPPRIFSDRSVNVYFQEWAPLFPVLHKPTFLRIYEEFVADPEKVKCHHKIAQLHLVFSIAGVSSEQPDYPQLAACEKQWTKAIESMVLENTMSTLQCLILALLYCAIRADNKRVQHFKGLAIGLSHRLGLHQSQKRFSFGALTLETRKKVFWTLYTLDCFTAATLGLPKMLKEDDIHTEYPSDTDDEYITEKGFQPTLPGEHTRLSSALALFRATRIMAAILEKNYPAVANHELSLQQMTSFEADLNAWYQELPAHLRLNFSQDKPSTDVTGSRSPILALAYHHIRTLIYRPVVGSSLGAKAAPALISIADSSKRIIQIVQLLEERNMSFSFCLNKFDLLALCGLTLLYQVVDLKADSKLSRDIEKLVNFTIKSMNQAKAPGCIDLARIAANLIRVDEHPSPLPPQAPMAAPSQRSSSKGSKKKPELQQEHEGMRRMTMPDTQTLERDFCPRSRQSFDSVTSSEASTNYQGHRLSVVTQPTRISTKTPISRVIPNLDYLSLNNTPSHTGASSPAGRSRMETPGLSVSPSGQIMAAVDPTAKMADVCNSEWETLLGSMDSNVYDAIYGGASLPSETIPANSNSVGWSPESWDMSSINVGDFGRNPEPPQSVLSMSDESLSSGEEVAPSELGLSVGSAEFNKLHMPEAYGFDLEGFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYR2</accession>
    <name>A0A7D5YYR2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYR2"/>
    <dbReference type="GeneID" id="26240432"/>
    <dbReference type="KEGG" id="mbrn:26240432"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="171" mass="17967" checksum="4D0DD1C8940B0A94" modified="2021-02-10" version="1">MARAAQHNALAPWSCSAPARSGPSAGSGAPGRHQNRDPPAQPGILVSGMRDRTLAPADDTSPRGIVDQSAHLGPATPWAVAAAARFKALALDAHVRETSSRAPTPFLLRAATWYVGMPAGGEARRDEPVDPWTRHVDGDGPAGRGGAAVRRCGPDIRRPLGQTPWRIVCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYT3</accession>
    <name>A0A7D5YYT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g099300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546416.1">
        <property type="nucleotide sequence ID" value="XM_014690930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYT3"/>
    <dbReference type="GeneID" id="26240839"/>
    <dbReference type="KEGG" id="mbrn:26240839"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20863" checksum="87D86CC942F3DC55" modified="2021-02-10" version="1">MAAPADKTLKNLNGQWTVNKELSESTDPALTIQGIGYFIRTGISYATISLSVNQYEAPPKPPNESTDTVVHIDIDQSASGLTNTQENRCLDNTYRDHTDWLFGHVKGRSTWLGLDEIEDAYLKNGWEAEADGKLIFSHVESLDAGWTATQVWGFQLVNGERRYCRNIVVAKGSERAEFRLVYDYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZD7</accession>
    <name>A0A7D5YZD7_9HYPO</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g097880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546554.1">
        <property type="nucleotide sequence ID" value="XM_014691068.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26240977"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028805501" evidence="2">
        <location>
            <begin position="16"/>
            <end position="367"/>
        </location>
    </feature>
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        <location>
            <begin position="193"/>
            <end position="367"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="367" mass="38414" checksum="10020C0A30E5B5A3" modified="2021-02-10" version="1">MRSIFLPVLAGCVTAQFSSPSKESALELDKQIDITWNTAGLEEPIAINLVPAGVAGRTVIAQQVAGLSAEPFEMISTNGNTVGIQNSGLLQWAPDLSIAAFPSFNMVIVDSKARVVVSEEFTILSLVQQPAIVTRLIPIATDVVATDSEGVVATQRVTSTSQMLLPLPTEPIKLHMSGTQVVDAMVTGVNEQAPKPTEDVNKDGQKEGLLPLPGVEGEEEPVAGLKPLPNVSESTTTSSAEPEQTEARKGSGNGDAAAAGKKNQGSNKNMQGKQKEGGGSKNNDKQANSGNSGASKSGGGKDGNKSNNKNMANNNNNSNNNNNNNNNNNNNNNNNNSNNSNKSNNNSNNNNNNKGKMQVSKAKKPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZE4</accession>
    <name>A0A7D5YZE4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g097940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131536.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90968167"/>
    <dbReference type="KEGG" id="mbrn:90968167"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028836421" evidence="2">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="62" mass="6889" checksum="4C65E4666386FE47" modified="2021-02-10" version="1">MKVAVIIAALSVAVMAFDGPAPIDHGRRIDKRDREQEFGRRHGANIPGLSFMEQREEEAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z189</accession>
    <name>A0A7D5Z189_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g034620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI66587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546859.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z189"/>
    <dbReference type="GeneID" id="26239422"/>
    <dbReference type="KEGG" id="mbrn:26239422"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="274" mass="29970" checksum="FF09B012012EBEB9" modified="2021-02-10" version="1">MSYQPQGYQQQQQQQQQPHYPPPPPHPPQQPQPQQQQQHHPQQQQQQQQSSIDSGSFPGGSYNIAHRDTNAILNVNLQPGGTVRSKSGAMIHMSGTIQLQGNIKFSMKKLFTGGRMSESTYTGPGRLALGPTLMGDIITLHVDGRTAWTVGKDTFLACTPDVAMETKSQGISKSMFSGEDLFVYRVGGQGLLWLTSFGAVDRLDLQPGEQHIVDNGHLVAWSCDYRIEKAGGGAMSSLKTGEGLVCRFTGPGAVYVQTRNMDEFDSYISSRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1L0</accession>
    <name>A0A7D5Z1L0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Desumoylating isopeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DESI1</name>
        <name evidence="7" type="ORF">G6M90_00g062870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542595.1">
        <property type="nucleotide sequence ID" value="XM_014687109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1L0"/>
    <dbReference type="GeneID" id="26244544"/>
    <dbReference type="KEGG" id="mbrn:26244544"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="135"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="295"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="576" mass="62866" checksum="6A423D57C554B54F" modified="2021-02-10" version="1">MDVQLLVYDLSRGLARQMSMGLLGFQLDAIYHTSIQLNGREYVYDGGIIAITPGSSHLGQPLEKIHLGTTNLPLDIIEEYLDSLRPIFTLEAYDLFRHNCNNFSDSFANFLVGKGIPSHIVSMPQAVLDSPMGRMLLPQLTQGINAGRSNGSILGLEQSAQVSSNGSRPHGVKVVATLDELTRLLDGARDSCAIVFFTSATCPPCKMMYPLYDRLAEEFGNQVTFIKADVSQPQSMSISHNFSVRATPTFVTMLKGKEETRWSGASQTTLRNNIQLLVHAAHPSHPHENLRLPSFSDPNSRPVLYSKVPPMAKLEAKMGDVAKRPQIQKLKSFLEARSTLGPQDAVLPELEELSDCIRDSVSQLPPEVLFAVIDLFRCALSDPRVSAYSSEEAEHKTIKTVLNSVNSLGSCPYALRLVTIQMACNMFSTPLFAHEVLQHASLRSALVQLVTTSFLDDAHNNIRVASASLLFNIALAGRGERDRDSSAGLPEEDQVELAAALLEAIAQEDKSVEALQGMLSALGHLVFGISLGGELADLLRALDAQGTILAKTKLFPNEQLIQEVGEELLGKGLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1Y3</accession>
    <name>A0A7D5Z1Y3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-coumarate--CoA ligase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">4CL2</name>
        <name evidence="4" type="ORF">G6M90_00g052540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540382.1">
        <property type="nucleotide sequence ID" value="XM_014684896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1Y3"/>
    <dbReference type="GeneID" id="26246744"/>
    <dbReference type="KEGG" id="mbrn:26246744"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04433">
        <property type="entry name" value="AFD_class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="602" mass="65115" checksum="AA76C741CF8BECE9" modified="2021-02-10" version="1">MAEIDGGPLINTTSLLGHLEQGLGKSYNKPGIISTHQPANHLSDLLALAKSHDDQEREDAYTHTKTSTIYDGENGYNYLTLTYHQIHSIAKCLAAGLLTNGVQPKSTILMLIPNGAEFGLLLWTSVMARLTISCADPDVLAATGPDELPHLLWTLEPSIIVAQDTRTVLEIDRLVDDFPTVRPLCIHVDRLAKKSGWITLSEIMEQGNGPAIDRDEIIEAARSDDPERIHSVLFTSGSSGRPKGCPMRVGGQTHYMLSQSWLVDERACPLALQQAHPSRAIAHLQILLTWRAGGTAVLTGRGFCVSDIVEAIRRLPITFVVLSPPMVHEISKEVTNASLNTDSVQTVQVGGDAVTAGILAKCATAFRGAKVVVAHGMTEGGGSFRWPFEHTPMSQLPHFGGLCPVGLVSPGSVVRIWNTAEASVCKRGESGALHIRSGSQIPNYMSGASETSFYEDGQGRWFRTGDVAVMDPKGLVYILGREKDMINRDGVMIMPAPLQNCIEILTGEQAVAVSVTSKSQGEQLFAVLRSLASNSPGDINRHIEKMLGKQYVLDGLLTLEQLGLAAFPVNATHKIMKSEIKTALLKYLQSHRDSNMTAGTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z275</accession>
    <name>A0A7D5Z275_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g014220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549100.1">
        <property type="nucleotide sequence ID" value="XM_014693614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z275"/>
    <dbReference type="GeneID" id="26238544"/>
    <dbReference type="KEGG" id="mbrn:26238544"/>
    <dbReference type="OrthoDB" id="147332at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="121" mass="12770" checksum="0627778534046E1A" modified="2021-02-10" version="1">MVCTKCQKLSKTTLATPDVKKKSEMYYGSPAASSSKPSGSKSTTLGQSGVVKSKLLSKSAKNPYAQYSSSCTKCKAKVSQGHSLCQTCAYKNDSCAICGKPNKKKKADAAPTVTGQKFTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2A6</accession>
    <name>A0A7D5Z2A6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARS</name>
        <name evidence="9" type="ORF">G6M90_00g083940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543610.2">
        <property type="nucleotide sequence ID" value="XM_014688124.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2A6"/>
    <dbReference type="GeneID" id="26243787"/>
    <dbReference type="KEGG" id="mbrn:26243787"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="613" mass="68950" checksum="4A8767CE78A45680" modified="2021-02-10" version="1">MPQFLTNQRAEKPSVATAGPQPTTRPSPSSPVLPVTQGIWNKMAIPLFLLAALALAFRMANGTNHHQNGTAKPNFIFIMTDDQDLHLNSLEYQNIVQRQLIDKGTTFKKHFCTVALCCPSRVSLLTGKAAHNTNVTDVSWPYGGYTKFATQGLNEAYLPVWLQSYGYNTYYTGKLMNQHSTRTYNQPFAKGWTRSDFLLDPGTYSYLDAIMALDKNEYRSIKGQYSTDVIANRSLEFLDNALAAGKPFFLGVTPIGPHANTGFTTPIPADRHKHLFPNVSIPRSPSFNPSTPGHVNYLKNLPQLTSTQIQYSDNFYRARLQTLQAVDELVGGIVDVLEKVPEVLANTYIIYTSDNGYHIGQHRLPPGKTCNIEEDINVPFIIRGPGIAAGKEVSFPTSHTDIVPTLFKLAGIPLHEDFDGVPIAVTPEDQRRPVRKNEHVNIEYWGQGYLEGEVFGNLRGAFSKNTYKTLRLVGDKHDFMYGVWCTNEHQLYDMKADPHQMTNLYGSEEETSGYDIPALSARLDALLLTLKSCKGKVCREPWKTLFPDPKDNVRSLDNAMDTKYDDFFFNQQKKVTFSECVNGYITEYEGALEPVGYVDWDRYLSENTWADET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2D8</accession>
    <name>A0A7D5Z2D8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall mannoprotein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g086370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542477.1">
        <property type="nucleotide sequence ID" value="XM_014686991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2D8"/>
    <dbReference type="GeneID" id="26244991"/>
    <dbReference type="KEGG" id="mbrn:26244991"/>
    <dbReference type="OrthoDB" id="4940711at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028885591" description="Cell wall mannoprotein 1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34160" checksum="64AF8F9F11CDAAE2" modified="2021-02-10" version="1">MKFIEVLSLCAAAAAAPLADVDGKASANPSVATPSMSAVPSSPIPQELLVKADVIAKAKKIISETHTLGNTTGYEGVSASHSKSAWAGVGAEIKAIINILDKIGENGKQNDELLKDEQHHISVVVAKLNEKLDVEPQPKPLQACDKHANATWTPQVSSVEVEIKSILSKLQKTKVQGEAVAVRQVNLLVRLLSLLTAKVEAEIKAGAIRNRGVHIDVEVHELTLRLAKILTIKAGINTWNLKSTNASANVNVEIHSVLVKVLGLLRVEANGDAKAGVSHNQTISGDVSSDDSKIQLLEGLLKVLAEADVDGKAKTDVDVKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3N6</accession>
    <name>A0A7D5Z3N6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cell wall integrity and stress response component 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WSC4</name>
        <name evidence="12" type="ORF">G6M90_00g047080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544830.1">
        <property type="nucleotide sequence ID" value="XM_014689344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3N6"/>
    <dbReference type="GeneID" id="26242171"/>
    <dbReference type="KEGG" id="mbrn:26242171"/>
    <dbReference type="OrthoDB" id="2537459at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049328">
        <property type="entry name" value="TM_ErbB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21314">
        <property type="entry name" value="TM_ErbB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028823149" evidence="10">
        <location>
            <begin position="29"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="11">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI67906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="308" mass="32344" checksum="DE78E25F3CCBE94E" modified="2021-02-10" version="1">MPSLNLTGARGVARLLLMTASLVSLADAIDVDICASLNTADMNRNLSVFQTNGLCHDLCTPQGFVYAITQSNSCWCSNYTPAKSAQVATSKCSLGCPGYPDEKCGGPGVYGYVFLNIAQPSGTKGAGSSTTSESTEATSKPTSAISTLTADGTVKTVTIIPTETGHTAGDNQGASVQDSGLNTGGIVGIVVGVVGGILVLAGLIIFFYLRRKKQQQENDYQDDPSIRGSSSGMMGSGRPEMSRAPGSPGSTGNRSSTLQIDPRMDPFQQTLYARSGSRESVNTLRDDHDYSRRIQQPKVLRTTNPDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z447</accession>
    <name>A0A7D5Z447_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BolA-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BOL1</name>
        <name evidence="3" type="ORF">G6M90_00g025600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548023.1">
        <property type="nucleotide sequence ID" value="XM_014692537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z447"/>
    <dbReference type="GeneID" id="26237467"/>
    <dbReference type="KEGG" id="mbrn:26237467"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI66288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="118" mass="13340" checksum="2447CEF2A22B9DB9" modified="2021-02-10" version="1">MSSNTPMEDAIRAKITAAFDPQTLEIYNNSHLHSHHKAMQGVTSKETHFRLVITSEAFKSKVQPARHRMVYALLRDEMALEGGIHALELRTLTPEEEERQNKKKAAEAAAKEEESKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4C1</accession>
    <name>A0A7D5Z4C1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone acetyltransferase ESA1</fullName>
            <ecNumber evidence="4">2.3.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Histone acetyltransferase esa1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 24">protein 2-hydroxyisobutyryltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 25">protein acetyltransferase ESA1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 26">protein crotonyltransferase ESA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ESA1</name>
        <name evidence="30" type="ORF">G6M90_00g073240</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:53909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2-hydroxyisobutanoyl-CoA + L-lysyl-[protein] = N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:131780"/>
            <dbReference type="ChEBI" id="CHEBI:144968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545740.1">
        <property type="nucleotide sequence ID" value="XM_014690254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4C1"/>
    <dbReference type="GeneID" id="26241773"/>
    <dbReference type="KEGG" id="mbrn:26241773"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF218">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE ESA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 30" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="29">
        <location>
            <begin position="215"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="85"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="28">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="27">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00074445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00076782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="QLI71143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="501" mass="57666" checksum="C8C3A576DE526F2F" modified="2021-02-10" version="1">MAVGTPAGEPTVGSDTPRQRGIATPDTLKTGCIAWVVKDGQPRRAEILSIKETKSGKQFYCNFDNFNKRLDEWVPVTRIDFTQEVEWPNPDKDKSKDPKAKKTTSQTKKAQVPKKGQKRPSKREQSIQSEAATPHPWSEFVESQQQRQTSSVGPDVDSQTQASADATTTPAAADDIEVDDKDDDVKKEEGEFSREEEIEKLRTSGSMTQNPAEISRIRNISKVQFGENDLFPWYFSPYPEVFSQEDVIFVCEFCLSYYGDETAFLRHRKKCTLQHPPGNEIYRDDYVSFFEIDGRRQRTWCRNLCLLSKMFLDHKTLYYDVDPFLFYVMASRTDKGCHIVGYFSKEKESADGYNVACILTLPQYQRKGYGRLLIQFSYELSKIEGKLGSPEKPLSDLGLLSYRQYWSENILDLLMGYNERDDKVTIEAISSALAMTTQDVEHTLQAMKMQVYHKSDHKIVIPENLIKQREKQKLKLRRVLDPGRIQWKPPVFTASSRTWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4N1</accession>
    <name>A0A7D5Z4N1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-fucose-proton symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fucP_0</name>
        <name evidence="4" type="ORF">G6M90_00g065700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986744.1">
        <property type="nucleotide sequence ID" value="XM_066130808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4N1"/>
    <dbReference type="GeneID" id="26247012"/>
    <dbReference type="KEGG" id="mbrn:26247012"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="465" mass="50592" checksum="8613D6A0BFA245A3" modified="2021-02-10" version="1">MTTKPSHLRRQPLRVHDDDRTNAAEMTLRQSLFPICLVTVLFFLWGFSYGLLDTLNKHFQNTLHIDKSRSAGLQAAYFGAYPLASLGHAAWILRHFGYRAVFIWGLCLYGVGALLTIPAIKSHSFGGFCACIFVIGNGLGSLETAANPYITVCGPPKYAEIRINISQAFNGIGSVVAPVMGSYVFFTFNDQDALRNVQWVYLAIAAFVFTLAAIFLFARIPEITDADMEFQAAEAHAVDNDLPFKKQYRLFHAAFSQFCYTGAQVAIATYFINYVTDTRQGTSNAKASQFLAGAQGAFAVGRFAGVGLMNCFKPRAVFGVYLTLCMVFIAPTITQRGNTGLALLYVTLFFESICFPTIVALGMRGLGRHTKRGSGYIIAGVLGGAVVPPLTGHVADMHSTATSMVVPLCFFFGAWSYALAVNFVPWYKDTIDAYAVTEVGVGPTIAVAQDVEMQKGVGEDRGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z569</accession>
    <name>A0A7D5Z569_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase PP2A regulatory subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">paa1</name>
        <name evidence="7" type="ORF">G6M90_00g087910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987328.1">
        <property type="nucleotide sequence ID" value="XM_066131317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z569"/>
    <dbReference type="GeneID" id="26244838"/>
    <dbReference type="KEGG" id="mbrn:26244838"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="90"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
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            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="5">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
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        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="550"/>
        </location>
    </feature>
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        <location>
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            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="623" mass="69359" checksum="4B312B59F6DE6E08" modified="2021-02-10" version="1">MTDATNTNDELYPIAVLIDELKHDDVLLRLNAIHRLSTIALALGAERTRDELIPFLDESVEDEDEVLVALSDELGGFIEYVGGPSYGHVLLSPLENLAAIEEPVVRDKAVESLNKICESLDAQQVEEYFIPLTIRLSKADWFTSKVSGCGLFTTPYRKVSPPIQEQLRQQFGLLVHDDTPMVRRQAATNLAKFVKEMPASIVIDEMIPLFQHLVQDDQDSVRLLTVEILISIAEVVPKEQQSSHGVLLTSLRNLIDDKSWRVRYMIADRFEKIAKAVDEEVVSRDLVPAFVKLLKDNEAEVRTAIAGQIPGFCALVERSTLLNDIMGSVEDLVSDSSQHVRAALGTQISGLAPILGKQETIDHLLPMFLQMLKDEFPEVRLHIISKLEQVNQVIGIDLLSQSLLPAIVQLAEDKQWRVRLAIIEYIPLLASQLGVKFFDEKLSNLCMGWLGDTVFSIREAATHNLKKLTEVFGVEWASEQIIPKVMGMGSHPNYLYRMTTCFAISTLATVVSINVIAKSILPMLDKMVDDDIPNIRFNVAKTYSVLINALRRLPDEGTLYSLEKEGAEIVPSPKGQELIQQRVLPNLTKLQKDDDVDVRYFATTAAAEATGSAQGGEPMNTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6C3</accession>
    <name>A0A7D5Z6C3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g034170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543344.1">
        <property type="nucleotide sequence ID" value="XM_014687858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6C3"/>
    <dbReference type="GeneID" id="26244145"/>
    <dbReference type="KEGG" id="mbrn:26244145"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="93"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="38879" checksum="5271D35B45CE9DCC" modified="2021-02-10" version="1">MSSRNYPRPPQRDSWFAPLSVDLIVKVLNVTFLHPFVCWMIPLCFRAQTVRWEAPRMIASIAWATFITLCSMAGVVNQRIAYGLPREVDLSEEVIVITGGASGLGMLVAEVYGMRGASVAVLDVNEMENGEARGVTYYKCDVGDKAQVKKVADEIERDLGTPTVLINNAAVVIGKSLLNLTLDEIDSSLSTNLLGPFYCLKTFLPAILRGGRGGTIVNISSVIGHLGAAQLSDYAAAKAGLTAMHRSLTAELRETHPEIRTVLITPGQLSTPLFYGVQTPNSFFAPVVEPVDVAKEIIGAIDNGRGATVGMPLYARWVDWYNVLPAGVQVLARWVAGVDRGMRTFIGRQGLSDELTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6F3</accession>
    <name>A0A7D5Z6F3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g075500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545548.1">
        <property type="nucleotide sequence ID" value="XM_014690062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6F3"/>
    <dbReference type="GeneID" id="26241581"/>
    <dbReference type="KEGG" id="mbrn:26241581"/>
    <dbReference type="OrthoDB" id="5426707at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9590" checksum="4872F9563BB2E76C" modified="2021-02-10" version="1">MPFGRRTHHHTTTTTTRPPRRGLFSRRPRHAHHQKRKPTMKDKVSGAFMKLRGSLTRRPGLKAAGARRMHGTDGRGGHKHGHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6K8</accession>
    <name>A0A7D5Z6K8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-mRNA-splicing factor dre4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dre4</name>
        <name evidence="4" type="ORF">G6M90_00g035250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546919.1">
        <property type="nucleotide sequence ID" value="XM_014691433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6K8"/>
    <dbReference type="GeneID" id="26239482"/>
    <dbReference type="KEGG" id="mbrn:26239482"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000035">
        <property type="entry name" value="Putative ff domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="581" mass="66110" checksum="B872A3785B6B99E2" modified="2021-02-10" version="1">MASAGGLKSTYKPSAAAAAASAPLPPGWTEHTAPTGHKYYYNASTKESTYQRPGLPPPSAVSAQDAYSPYANLPSLADPRVANAYLAQLNPQNQPRARGAHSGRGGSRGGFEGRPKPQPVDKPRKAEKIPGCEPWLLVYTKYSRRFAYNPVKNASYWRIPEKLMEGILELDKARIRGKATGTAEDAKSEKNAENKTGDLAEKQHDYDSDEYEEIEVQVTDDEGGDSLDTEHPSKRRRTNKGESEEEVVEEEGEEEEEEEEEEDEADGPVEFTEADIAAQLQAMGEEYGLEPGDYDDGNMESWPEGTEGVEFSEEDAKLLFKDLLNDFNINPYSPWDKLIEEGKIMDDPRYTALTTTRARKECWDEWMREKITELKEQRAKQEKKDPKIGYMAFLQEKATPKLYWPEFKRKYKREEAMKDMKLSDKDREKAYREHISRLKMPQAKLKSDLTALLRAQPIHLLNNKSSPTSLPTPVLIDLRYISLDPKIRDPLVEAYLQTLPPPPEDVAASEEDGEKKKKAREARGKREKALEERNRVVEEQKKRRERDLMASKARLRDEERELEIAMRVGKRGLQSQLQDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6M8</accession>
    <name>A0A7D5Z6M8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 55A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g067390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987040.1">
        <property type="nucleotide sequence ID" value="XM_066130852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6M8"/>
    <dbReference type="GeneID" id="26246605"/>
    <dbReference type="KEGG" id="mbrn:26246605"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11030">
        <property type="entry name" value="CYP105-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000018">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41007" checksum="D20A690481466DA0" modified="2021-02-10" version="1">MEPPAEYARLRATDPVSRVELFDGSLAWLVTKYKDVTFVATDNRLSKIRTRPGFPELSAGGKEAAKAKPTSMVNHFFTPEYIKSLQPYIQKTVDDLLDALKAKGCASGPVDLVKEFALPVPSFIIYSILGVPFEDLKFLTEQNAIRTNGSASAREASAASKGLLEYLEKLVDLRAAAPKDDLISKLVVEQMIPGNISKADVVQNAFLLLVAGNATMVNMIALGVVTLFQHPTQLAELTADPSLAPAFVEELCRYHTASAMAIKRTAMTDIEIGGKLVKAGEGVIASNQSANRDEEIFTRPDEFDMHRKWPSQDALGFGFGEHRCIAEGLAKAELTTVFSTLFQQLPNLKISVPIPEIKYTPLHKDVGIQELPVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6V0</accession>
    <name>A0A7D5Z6V0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g097260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546615.1">
        <property type="nucleotide sequence ID" value="XM_014691129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6V0"/>
    <dbReference type="GeneID" id="26241038"/>
    <dbReference type="KEGG" id="mbrn:26241038"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028861423" description="Fungal lipase-type domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI73223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="400" mass="44815" checksum="86355485CF2EF4BF" modified="2021-02-10" version="1">MWSWALLIQPLLWWRLAHSSQHHVIDSPSPNNESSPSSISTSLFADLERLSRLVDVSYCIGSTGVHKPFQCLSRCKEFPGLSLAMTWSTGFLMGDSCGYIAVDHGSRWMENQDGGVSGERNGAIIVAFRGTYSIANTVVDLGTIPQEYVPYPAPDDDDSDFLENCRRKCDNCTVHMGFLHSWRMARGTVVPELKALRKKYPSYKIQLVGHSLGGAVACLAALELKLSLGWDNLVVTTFGEPRVGNYQLARYIDKAFQLDGTRNLEHRTYRRVTHNNDPVPLLPLEEWGYSPHGGEIYISKQELQPTEEDIRSCVGDSDPECSAGAETSLLEDMRRLLHFASASPSIEEYIVARTLPTRLKIWQLFFAHRDYFWRLGLCVPGGDPANWGRGWSGGIESEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z711</accession>
    <name>A0A7D5Z711_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein bud20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bud20</name>
        <name evidence="13" type="ORF">G6M90_00g042170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547556.1">
        <property type="nucleotide sequence ID" value="XM_014692070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z711"/>
    <dbReference type="GeneID" id="26240119"/>
    <dbReference type="KEGG" id="mbrn:26240119"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI68309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="120" mass="13832" checksum="757F1AC9984F6334" modified="2021-02-10" version="1">MGVGNKRTITKTRRKTRDVDQIKADLLSSRHLAQFKDTKAAEDLPGLGRHYCIECAKWFDRESTLNSHRRGKPHKRRVKQLREEPSPEPQRMPGLDAESQIDNRHDNVEHDASGDMEMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9U1</accession>
    <name>A0A7D5Z9U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g081610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543398.1">
        <property type="nucleotide sequence ID" value="XM_014687912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9U1"/>
    <dbReference type="GeneID" id="26243575"/>
    <dbReference type="KEGG" id="mbrn:26243575"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18389" checksum="4E494031EE07925A" modified="2021-02-10" version="1">MASGAFFDPLVALRALPLVSSTCTLLFGWDQTFFLGIMNRPENRAKSKPLLQSYFNTFFYRGLPFVVGAIGVSTWSGVGNLFAQRSVLQSRQSFWWYAAGTIAAASHLLFVPLIAPSVRDMMDGKEQTDANDCLDEWLRVNNVRTLTVDLLAWGAFMVAAGKTLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZA96</accession>
    <name>A0A7D5ZA96_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Highly reducing polyketide synthase sor1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sor1</name>
        <name evidence="13" type="ORF">G6M90_00g081120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543353.2">
        <property type="nucleotide sequence ID" value="XM_014687867.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26243530"/>
    <dbReference type="KEGG" id="mbrn:26243530"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="10"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="991"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2562"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1148"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1023"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI72248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2645" mass="286294" checksum="B43C181FF7EE7106" modified="2021-02-10" version="1">MDTDNSEWASEPIAVIGMSCKFSGGASNPDKLWDLMASGKTGWSEIPKERYNLEGVYHANHERNSTTHVKGGHFLDDDVAAFDAAFFNYSAEMAQAVDPQFRLQLESTYEALENAGLPLSQVMGSQTSVFAGVFTHDYQEGIIRDEDGLPRFNVVGTWSPMSSNRISHFFDFRGASMTLETGCSTTLVALHQAVHTLRNREADMSVVTGANVMLNPDTFKAIGSLGMLSPDGRSYAFDSRANGYGRGEGVATIVIKRLSDALAANDPVRAVIRETALNQDGKTDTITTPSGAAQVELMRECYRRAGLDPRGTQYFEAHGTGTPAGDPIEAGAVAAVFAGGQGRDDREHYLRIGSLKTNVGHTEAASGLAAVVKGVLCLEKGLIPPTVNYERPNPKLKLDEWRLKVVRMMEQWPDSLVDGPRRMSINNFGYGGANAHVILESADPWTSTSGLDLEPVSGRHSKNGNKGHVHGNGYTNGSHDTNDATDDAKVLVLSARDERACQQMVSELKAYLEKHRSLGHEDSEQLLRNLSYTLGERRTLFPWVAAHQVRLDKDGGVEAAVQALDSPRFKPGRRAPDRPRIGMIFTGQGAQWHAMGRELLASYPVFRQSIEEAEAYLRALGADWSLLEELQRDAKTTRVHATKISIPVCVALQVALVRLLEAWGITPSAVASHSSGEIAAAFAVGALTHRQAMAAAYYRAVLVADETQHAPGAAKGAMAAVGLGVEAVQSYLDMLTTGNGKAVVACVNSPQSVTISGDADAVQEMEDLCKQNDVFARRLRVQQAYHSHHMDPFAEAYRERLRVEMARDVVQGGKQHVQAAKQQLGVVFSSAVTGGRITDVKEIASPNHWVGSLVQPVEFVDAFTEMVLGDPDDPTGRSVDVLLEVGPHTALGGPIREILSLPEFEGIELPYWGCLVRDEHAGDSMRSAAINLFRQGQPLIMDQINFPLPAYDGESPLVLTNLPTYPWNHTMRHWLESRVNRAIRERSQPPHELLGMPVAGHDPSTAVWRRTLRVTETPWVRDHMVQGAIVYPGSGYICLAIEAARQMEKVAGAADRDKSGGTISGFRLRDVHFLFALVIPDSADGVEIRTTLQPVPEREIGARGWRRFEVSSVTPDNRWTLHAKGMVMVEREAAAPETAERRPLSIYTRHPDPQDLFANLRARSVYHGPLFQNTTKIIQDGREPRSVCDITIRHEASSDTDPVEAAQNTLLHPITLDAIVVAFYSALPSVGALQEDPKLPRSVASMWVSSNISRETGRTLRCDTRLLHGDAQSGIADMTVVDGQTDATVLKIHGVELASLGRGSGRTARQHAAVPSKWEQELCSKLVWGPDLSLRNPLALAQIKKELVHAESATETDKARSLQRLCSYFAHDALQSLTSEDVARLQEHSHLAKYHAWLRELTKAAKNCALDEPEKRQEYIASDAPQGIDEKWVSRLGPLLPSILRGELHVDQVSGPLLNEYHANAMRRSVALGQLSTLLCKIAHKNPSARVLQIGAGTGALATRRMLETLGASKTPLVVSWHITEPSWDSLEDARAQLADWTHLLEFDQLDIEQSPAKQKFTPGSYDVVVAFHALRATKDATSAVANVRSLLKPGGTFLFAEVTKDQVDVDFTFGLLPSWWQGEEGCDHPTLSASSWDRLLRDAGFSGVDLEIRDSESDIIHTNSVIMSTVPLAKDQSPDLGRAHHRESFVVVTSSKAPPPPGFVDLLSRRIQALTGAGSLAPEHLVLEQSSSDTYKAKTCVFLGEIDEPILADLDAVRMEGLRAMVTQCSGLLWVTTGGTVASEAPERAVHQGFLRVLRNEYIGRRLLSLDLDPAHAADRWSSGGEVAVSAIVQVLEEGFGRPNTEAGPAEFEYAERDGVLQVPRYYKDEKCNDMVAGPLVPSWGEVLPVVKDDKGSIDAVASIPLEPLFQEDGTLRLEVGIPGHLDTLAFLHYEADDEALTPELVEITPRAYGVCSRDAMAAMGQLKNRSMGFECAGIITRVGAEAQEKGYNVGDRVMALLAGASFASHARVPWHGVIQIPYGMDFVKAASLPLAFTLAYAGLVDTARLSAGQSVLIHAATGAIGQAAIMLAKCLGVTDIYATAGSQEKRDLVQREYGIPAERIFTSRDASFATAVLAATKGRGVDVVLNSLPGPLLQASLDAIAPLGYLIEIGKKDIESNSLVALESFSRGISLVSLDAPTLLRRGPDVRRALGEMVRLIELQVLKPVHPVAVYPMQDAQAAFRFVQTGAQMGKVVLSAGPDELVHVVPRPKGVTARVRLQADASYLVVGGVGGIGRSVAHWLVAHGARNLILLSRAAGDLDLDVNNNTHGALFVRELREAGCRVKPVSCDIALASSLTTALRACEDDGFPPVRGVVQGAMLLRDAVLEQMTLDDWRGGLRPKLHGTWNLHTEFSQPASLDFFVMLSSVSGVVGIASQANYAAGGSYEDAMARWRQSRGLPGVAIDLGPISDIGYVSTTAKVAERLRKDGDFAMLDEDTVLRALHAAVLHPLGGRSQIIVGLNTAPGPQWDANGRSQLGRDARFAALRPRARASAPPADGESAGTSLAAQLAEATDQQEGARLVGAAIAAKLADIFMTPVAEIDLAKPPAHFGVDSLIAVELRNMLVLQAAADISIFNILQTASLAALAALVAEKSRHLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAR4</accession>
    <name>A0A7D5ZAR4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g105260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541514.1">
        <property type="nucleotide sequence ID" value="XM_014686028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAR4"/>
    <dbReference type="GeneID" id="26245764"/>
    <dbReference type="KEGG" id="mbrn:26245764"/>
    <dbReference type="OrthoDB" id="4849731at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="324" mass="34022" checksum="8F052012C7DAB307" modified="2021-02-10" version="1">MVSSRRYALVALVVSRKHPLASARSMLQPTTEPQPPETYQAGPSPTIAAVPHDHLAIFGRATTSAAELHTCGYLYGDANQAFTCGGSYFCATYSQYKAFGCCTTTSPCKFPTTCLPLESSAAASGADLSYTLYCSNTASPFCAIVQYADSSFLGYTFQRCATAATTFPIYYHATETASSGTTTNGYTLTTSSTTSTSTTTTTTPPPPPPPPPNSSSTPVGAIVGGVIGGVAGLAILGSAFMLLRRRRKKRAFSPTQQPFVSEYSYASGYPVSSVTESVASTPFQAPGPAYSPSSVGHAHDGQHWSQVHEMPTGPPEREAHELAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBF2</accession>
    <name>A0A7D5ZBF2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g101440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546203.1">
        <property type="nucleotide sequence ID" value="XM_014690717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBF2"/>
    <dbReference type="GeneID" id="26240626"/>
    <dbReference type="KEGG" id="mbrn:26240626"/>
    <dbReference type="OrthoDB" id="4938430at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="198" mass="21894" checksum="F2D98D1E075E0654" modified="2021-02-10" version="1">MPFQRSRRANLAHRPPRPSTACHVTKSPQGKGADCKREEDGYNVDDANSFPYVNTYPSSSSPSCCDDSTDWVMVQTDGAPQSNCSDDLHSYGPAQELTATNVQLFDNSNSTSASICAAGDNDGRRRCLRRRPKYRRGSAKTNASVATRESHQAENEQHLDPWAPISVDSYEFDVFAVGAWAMEGDTGLEPTYNYPRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBL3</accession>
    <name>A0A7D5ZBL3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540853.2">
        <property type="nucleotide sequence ID" value="XM_014685367.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBL3"/>
    <dbReference type="GeneID" id="26246466"/>
    <dbReference type="KEGG" id="mbrn:26246466"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="44906" checksum="9B392BBB459A8FBD" modified="2021-02-10" version="1">MSREEMEAIVHSAFPQSELTHVSAVSTSDSFNNRIYFLSVQQADNTTDEVVLKLNGRYFGPAKVQNEVACLQQVEKHCPETPSPRVLAWSEDGQAATFTTPYTSQTDDIRPARQNHTHNHGGWIMTTKLPGAAVPVSDLDNHSCRHLGRQMADMVADWRHNIPAQSRCGNLKLCRDGKDSPIIQGIVMDGLEPPAPLPTVNAYQSARLAHKMRELATTDTYAPNRHLLPLLQDFIDNHLPDMTLVPPATQSPLFVFTHYDLAPRNVLVSGWPPHITGIVDFEFAGFFHPMEEFVNDCVDGRADWPALLYAAYQERLEERGVATPAGSVDREVWNRNYWLEMVVSYVAPWWLPGEYMGQGLRDELRRAGAVVLDALEKVLRRPGEQMPVPAYGDGAGDLGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPN9</accession>
    <name>A0A7D5UPN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g017800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548752.1">
        <property type="nucleotide sequence ID" value="XM_014693266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPN9"/>
    <dbReference type="GeneID" id="26238196"/>
    <dbReference type="KEGG" id="mbrn:26238196"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="78770" checksum="F87DAA3583C8B1BC" modified="2021-02-10" version="1">MVISKNATSLAQGIASVLPQRLWYAVYSAAALVLIQVGIGIVLKAAQTDNHYAFSPSSSVTISEFLKMLLAMGFFYREWAAKVAQNAGRAYLPISTSHDSFPLRYEMERPLEENDKQREMGDEALPQNGLWVDPSFLTAIRKEVSTDIAFGLGLLSLFYVLINNLVFVSYQVADPATISLTKSGVTCITALVLMFTLNTKITGTQWLAIVLQVCGLLVTQYDPTAGGVYSVGVYLLLIFQVFLSAVSGVVNQGLLQASNASLHASNIILYGSGAWSNLLCHVLLRATKPDEPGFFEGILLLASLAPLNPNDEADANAIVKCLATAIATAILIFLSPMFFGTTFNFLIVPGSIVVFGASWLYAMNPTPKPNKNGSHASNSQHRPWTSSLLKLRRSYLVLYGIAQLITLAMIAAMSMSSFSASDAVGGASAAVTSPFEKTLAFVRWNGARPERIPHVMKYKPFFHTMHISMPNETTPGLGLNKTSLTEDAANITPLIYRQVAFTMQVILDTQPEITGLFYFHFDSWIDPLAWSDMNLENMYFPFLTDKTKEPFTICMSDTAKQGWWGWDRDVHQTAMNAASAARSSPLTRNYTVNDREWCLGWSDIYYIPRRFFQDYIRLSDVFSNPQFNVFHEVAIPTIVHIIDNSNRKNPHVPVVNHISDCWGDCCSSNPSVDDVLRYPCGHRLDYLNEMVTEAFYAKLASEASLLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UPX6</accession>
    <name>A0A7D5UPX6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sporulation-specific protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">spo5</name>
        <name evidence="6" type="ORF">G6M90_00g022200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548334.1">
        <property type="nucleotide sequence ID" value="XM_014692848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UPX6"/>
    <dbReference type="GeneID" id="26237778"/>
    <dbReference type="KEGG" id="mbrn:26237778"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000468">
        <property type="entry name" value="Related to single-stranded DNA-binding protein MSSP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="246"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="334"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="505"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="542" mass="58578" checksum="CBD3017D9F537FF8" modified="2021-02-10" version="1">MDAGNSVGGPYLPNPTGRNVHSHGPAHSAADPNAMLNQFAGLSLGGMSMPSSSAPMPMGHNPPPYMVGTDTPFVLAHMSAHQIGMNHHHTENPYQNLGIPGYGSPYVGVQMPFVPFTPGRAHIAQPRVERGHSDVPGLENRRGSYSTTESTPATPFYGTVSQRDDGPRVASLDRSAYTTPSPQQIGLPALHADPTKPAIAVVSDRTVDEYLQQEPAIPRAVPAVFTPPSQMKSLEQSLENRIPGNRNVYIRGLHPTTDDELLYKFASRFGPVETSKAIIDTGTGACKGFGFAKFFDSQDSEMCIRGFHRLGYEVGFARESFNSRLKAEGDEGSTNLYISNLPKTLTEVELGTIFLGTTILSSKILRDSMGNSRGVGFARFESREICDEIIKKYNGVGIGEEGLLMNIRYADTPAQKELKRVTAERRQFRTNEYNIGAYGTPLVGMSPTLYNQQSQWRRTLPVSRSGLSASSNEEGNVMRHSGTRRGLSEIAPNTITDVAAAATMSDSDEGVTIHADSSTVAGGTNENKSPSTKGARRDEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ40</accession>
    <name>A0A7D5UQ40_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serpin-Z10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SRP10</name>
        <name evidence="4" type="ORF">G6M90_00g004700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014686631.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26245148"/>
    <dbReference type="KEGG" id="mbrn:26245148"/>
    <dbReference type="OrthoDB" id="1063785at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="13"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="365" mass="39718" checksum="F7BA68C439C15A35" modified="2021-02-10" version="1">MAPSLQSIGRVGWDLLMKQCGPDSAPETVILSPLSITMALGMLAGGADESKKLGLSTKLGLQNAGELESVLHPLHTTLCGDAKDGPLALANAVFTDQSVTLFPAYQNFLKGFNAEHKQYPNLAEAASDINAWISDNTRGLIRDMLSPASLTNSHLALVNAIGFKGTWQTKFEPRDTRKETFSVTKDEETEVDMMYLRSQHLSSLETSTYKAVRLPYTLPESYPSTSLFAYLPNEGTSLSAVLEDIVKNGSAGDQFTSVKYDEFGFPKFEIDSKFSLVDTLAKLDYPIGGAYTEMADGQNQVQTIAHQAYVKVDEEGTEASGATAVIMTRSMNFDPKFLVFNRPFVFAIASDKPDAILFAGIYSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR05</accession>
    <name>A0A7D5UR05_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g014090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549113.1">
        <property type="nucleotide sequence ID" value="XM_014693627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR05"/>
    <dbReference type="GeneID" id="26238557"/>
    <dbReference type="KEGG" id="mbrn:26238557"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29450" checksum="D921E1B3D3965235" modified="2021-02-10" version="1">MYLRTVHAESRIPALRDLIRSYPLGVLTTAIPSSTEPFIQATHIPWLLDVQDESSETELGVLRGHLARQNPHSKVMIESVSSSSNNNNNNATNTNVLEQDVLVLFTATPSHYVTPQFYTETKPSTGKVVPTWNYAAVQAYGKARIYYDSKSDETSHFLTRQITDLTNHTEISIMDYTGQNGRPDQWNVTDAPDRYIELLKKNIIGIEISIDKLQGKFKMSQEMSKGDRDGVVQGFATLESDVARAVSEVVQERSEMREAAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URJ3</accession>
    <name>A0A7D5URJ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of nonsense transcripts UPF2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UPF2</name>
        <name evidence="5" type="ORF">G6M90_00g007560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549754.2">
        <property type="nucleotide sequence ID" value="XM_014694268.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URJ3"/>
    <dbReference type="GeneID" id="26239198"/>
    <dbReference type="KEGG" id="mbrn:26239198"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="472"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="677"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="916"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="926"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1134" mass="128227" checksum="5D0A26759737022A" modified="2021-02-10" version="1">MDRQRKRELRTLNIRAWDGEADILVVSNSLDSSLKKNTAFIKRLRTAISPATLATFLQEIRTLSLHKYLSEIIAACYEGLCRLKSPGEIEAGVEIVSALHQRFGPTEFTEYLAWLLGKGMATPDKTSLKSLAIEVREKEEKERITRQRALLRVITELWLVGVVRTLDDATKPDDATKGAAAGKAVELKNRASSTKAGGAAEPFPLEVLKDLLGYDREHANLPLLVIFVKSFSWDILGVKPTGSDGRKTVEEDGATSGQNDIVQVVDEATELNQTLDQQPFTPPDMAERFRKVLKKYFDDVAAHIVRDQKSIQSQARRNAEAYVKSGEVFEDRQANYEKQVKAQERLISNAQVIADAIGAEMPDLKESYDALATSSGSIGLVKTSEYLRTMGEGAGIWTDEDERRFYENLVDLKGKVPPILLEDGRRKKVDGEEQVGKKTDAASESSDAAKAAAEAVEDQSMAIANKTIGAQVDALLARLPELTNKDVIDQTAIDFCFLNSKASRNRLVKALTEVPKGRSDLLPSWSRLVATLGRYMPDVPKGLVDYLDAEFRSLQRRKEKDFLGQVRLSNIRYLAELTKFGVVPEHVVFHCLKVSLDDFSRMNIEILCNLIENCGRYLLKNPETAPRMASFLETLQRKKSVQHIGQPERMLIDNAVYYVDPPERPAIEQKERTPMELFIAKLVYSDMTKRNYSKILKQIRRLHWEETEVVSILEKVFSKPGKVKYGNIHLLGILLSAIYRYHPEFVVKVIDNVIESVNLGLEQNDFRFFQRRIAEVKYLGELYNYRMLEHPVIFDTMYKILTFGYGGPPIPGRLNPFDPPDDFFRIRLISTVLETCGMFFNRGAAGKKLDYFLSFFQYYIQTKSSLPMDIEFVVQDIFSLTRPQWKIATSIEEATKALQLAIIQDQKTAGIDRAAEVDDATSGASSDDDNADVDDVEQDGEGDEESASEDDEVEDGDDESANDSDFNDEAIVVTRQEEVVDPEDEADFEREYAKMLAESLESRKFERKPLFDVPLPVRPKNRESSTGAPQDQEPSAPNHKMAFSLLTKKGNRQQTRTVELPSDSTFAIAMKTQQQAEKEEQQRIKNLVLNYDLQQSEDQEGSERATTFYHNRVDRSSKDRGQRVRKLQLSDVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URN2</accession>
    <name>A0A7D5URN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g020310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548514.1">
        <property type="nucleotide sequence ID" value="XM_014693028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URN2"/>
    <dbReference type="GeneID" id="26237958"/>
    <dbReference type="KEGG" id="mbrn:26237958"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="181" mass="19538" checksum="37B6B8C4C3D09E1A" modified="2021-02-10" version="1">MHSNRPHPLLEQVPLTVSPFVSLPTATTLSYNYKTMPSNIPPSAMGIPTASEDPSQQPKARFVVSGSGHAAHPDDIIDSCRALLDHVTKVQESAERELQEFEDQIKQRDLAEKRRVAPGWLDSESRLLQPERMSAQAGPTAGATAQHQQQQDPPPMGAGTAQPVVDAGAELDRAFGGMALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URP7</accession>
    <name>A0A7D5URP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin-like protein Klp59C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Klp59C</name>
        <name evidence="3" type="ORF">G6M90_00g010210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549496.1">
        <property type="nucleotide sequence ID" value="XM_014694010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URP7"/>
    <dbReference type="GeneID" id="26238940"/>
    <dbReference type="KEGG" id="mbrn:26238940"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF0">
        <property type="entry name" value="FI21273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="36"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="611" mass="68137" checksum="92A12DF07F38A48A" modified="2021-02-10" version="1">MEEFITSNLDRYQWLLDRFKMQPKPKVTPNSDSSLDNLVCARIRPLAEEEVAAGLPASIFIRPREPGTFDAHELRHAVRGKPVLRSSAYTVDRSYGPDISTETIYEDAVQHLVPWVWGGGIGTLFAYGQTGSGKTFTISGIEKLAAKDLLEGNLQGDRKMFISVTEFAGNSAFDLLNGRRAISVLEDAFGNTQLAGALEHEVKAVSEVLAHIEYATKFRLTEATKRNDTSSRSHAVCRIRIEIHDIPGAEDGILYLVDLAGSEAARDRDTHEPQRMKEAKEINVSLSVLKDCIRGKVEADALIGTQTKKKPYVPFRQSALTKVLKHVFDPAGTRVCKNVIMACVNPCLLDISASRNTLRYAEMLRVFVPQVKGVKYRSDMPTTWNNEQLREWITANSGSPSVDATVLAPHEAGAQLLRLPAPEFETRCMKTPGVIHEQAFAFRQKLWQLHVDTRRSKQKAQVEEDDGPDTVLSHLNKFDRSSSREPDALTQSIPFKDRIRPGMAVSWTPTKEYDMGCSWEKLNIVLILCPAAAVGPTTQDTMGRRVDAGSASNKMVDGKYKRYLCAMVSPAVLPGAFEVSMWRYVVVDVDDMDKEVILEYDSATRFYHLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URR3</accession>
    <name>A0A7D5URR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helicase and polymerase-containing protein TEBICHI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TEB</name>
        <name evidence="9" type="ORF">G6M90_00g012320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985888.1">
        <property type="nucleotide sequence ID" value="XM_066129728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URR3"/>
    <dbReference type="GeneID" id="26238734"/>
    <dbReference type="KEGG" id="mbrn:26238734"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000005">
        <property type="entry name" value="DNA-directed DNA polymerase theta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="147"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="399"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="933" mass="103088" checksum="538A5AA848505B92" modified="2021-02-10" version="1">MKSMQGLLHKTSLQTAHEQQQRFFAPQSVAGQKRPWSSNDGFVTSHQHATTATNSPSHSIVHFQKAISLPSAPKRLSASKITQVSGHHTTGEYSQRRLISATPLSSQDSELDLAHQTYGLPRQIVSNFSLLGINHIYPWQKNCLKGPGLLTGERNLVYCAPTGGGKSLVADVLMLKRVIEEAGTKALLVLPYVALVQEKVGWLRKVVQHVKILDDSMPQGAENGPWRRRADYGTIRVVGFFGGGKVRATWDDFDIGVCTLEKANALVNTAIADGSISKLRSVVLDELHIIDDDHRGYILELIAAKLVCLGQQVQLIGMSATLPNLNLLAAWLHGHTYETRYRPVPIEEHLVYDGKVFRAGPNDGLGHTPSQLSSQDVSAGKTAPVRRIENSMHKEFTDSVLNAVVSLAHETACMGYGVLVFAGSRGVCESDARWISRVMPQLHELAADVLKKRLDLLGDLRSLSTGADPVLEETVLYGVAFHPNQLFPDAGLTSEERDLIAAAYDAGTILVCIATCSLAAGINLPARRVILHNVKMGGEYIGPAMLRQMRGRAGRQGKTQLGETYLCCRQPDLEHVLELMHADIPKVSSCLSTENRRIQRALLEVISIRLATSRESISDYFSNSLLQWSQSPDFVHKGIELSLEELQSMGLIMPDSSTGYAPTQLGKAIVASAIDPDDGVFVHKELVKALRAFVMDGEMHILYVFTPVHSFGTTVNWQVFRNEMEYLDESGMRVLQFLGIKPTSIIRLAQGAILKETTVEEKRMARVYRRFYLAMQLRDLCNEVPIHAVARKYDMPRGSVQTLSQTCQGFAAGMVKFCEHMGWGPMAAALDHFSDRLMAGARSELLALSKVPFIKSRTARVFFENGYRSVAALANANPKDLVPILMQAQPNKLRIKSQNDELMEEKMLAKANVISSAANRLWNIQMQAEMEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URU9</accession>
    <name>A0A7D5URU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g019990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066129847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URU9"/>
    <dbReference type="GeneID" id="26237988"/>
    <dbReference type="KEGG" id="mbrn:26237988"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="478" mass="51953" checksum="6162654BE2742D94" modified="2021-02-10" version="1">MATPELTIAKAALSASLFRADPASISRPSVDTFFQQVTSTLTQCSRPNVQVCTKPPFEKFFVPALVHAKIVSLEIAIQTCKDYILSNIIHSSGRSTALAKYLVALSNAQVDDAAHPRPSTKRRRLHVLYIVNDVLYHAARQGNQDFRTTVEAYLPPLISAAASFEKCPKHIKKLQNLVSIWKSKQYTSDAVIPKLEEALAGSTVSATPEPVNTSLKLAKEAPFILPSFHGDTSTAWYDLPAATWLPHLVPNSTKPMLPDLIRPIQLAPGPADNVVTAAVKALLSDAERIFSRDRRPDDAHIDVNEMGERIVLDEITGEVIGGETQTKRSIRVSIFSAQLFAQPPLFITILQTQAHVTFQKPQPQPQPQQKLHTPISLALALTLAITVTNPQPPQILQQQSPSRLSETISPANRQPQYAIQHAHTSPTGRIHRSLAATASSPPSTRLGARSCLCSSDDGCVERASSPATSTNSPSPSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URY9</accession>
    <name>A0A7D5URY9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g015900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014693452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URY9"/>
    <dbReference type="GeneID" id="26238382"/>
    <dbReference type="KEGG" id="mbrn:26238382"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="96"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="411" mass="46701" checksum="AB34DB2AFEC69EFA" modified="2021-02-10" version="1">MDPSEVSVRDDGQPTAPSTPPLRRRYSMEEDMYYNRVMVAPPRRLSQPPAYEPNPNDSDEGEDPGPGRRKGSQAVFDQSNEAEEGSESLPNYQSSLYIEGVFSRKHEIENTTKRAEDRHWHTNFVTLNGTALNVYTVKKDWGWGRSRDGPTICPDNPPWVRKSKLEKSYSLIHADAGIAADYTKRRYVIRIRAETDQFLLSCIELATFVKWLEALFAAIDVAAPIDDRDFPRDMSIPRIQRIRWYQGQSPALPGYAVSTEQSRNNETSVEGPELSSTTTQTDSNVGLSSSTRPPPTLQPLQEASANPPPRIEPLSRRISTSSYPNPSIDPHTGKWFPEHQWSSAHDLLYAKLCYSNLLFRSPRKSNYIISKGKQWFVDWGTGKMVRVLPPTYGEIDFFGPWQVIHTENPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USE8</accession>
    <name>A0A7D5USE8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">G6M90_00g024150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986006.1">
        <property type="nucleotide sequence ID" value="XM_066129934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USE8"/>
    <dbReference type="GeneID" id="26237609"/>
    <dbReference type="KEGG" id="mbrn:26237609"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="73"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI65656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="334" mass="35802" checksum="A4C7AC21E2DF131D" modified="2021-02-10" version="1">MADTAPNGGSILETTTNNAAAAYDSVTNGPVAQNVKDQNAKTQAEFSNLAASRKTPTTPAATGQPLTHYHSLFSELLSWKNPRASAIAYASIVSFIFAVRYLDVIRWGLKLSFMALAITVAAEVTGKVVLSHGLATQMRPRHYWTVSRATVDGMIGDVHELINFFVIEAQRILFVENVGASAAAGVAAFISYHLVKLVPYWGLAIIATTVAFFVPLVYTSNQELIDQHLKNASDAISAQTAQVRSVAQKQADQLTTMGKQYAGDYTGKVQEMLRGRGAPAPSGPPKQPTLVAPAKKPEFPTPPTEEPKSTKTAEPEGEVPEEPVIPETEPLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USF2</accession>
    <name>A0A7D5USF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nodulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g007710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549738.1">
        <property type="nucleotide sequence ID" value="XM_014694252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USF2"/>
    <dbReference type="GeneID" id="26239182"/>
    <dbReference type="KEGG" id="mbrn:26239182"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI65399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="342" mass="36875" checksum="3A6D2918AC8A18AF" modified="2021-02-10" version="1">MGQQNQQMRRARLVASVAATIISLACGTNYVYSAWAPQFAERLKLSATQSNLIGQFGNLGMYSLGVPVGMFVDRRGPRPFVLIGAFLLVAGYFPLHMAYDKAYGSVVALCFFSFLTGLGSCMAFAAAVKTSALNWPGHRGTATAFPLAAFGLSAFFFSFIGSVLFPGDPSAFLKLLSFGTVGLTFVGFFFLKVYPHSNYRAICHEEGRRSPSLSAHLRQSYSQSTPHGIRHSEEPGTSNTDSTNTHMASSPALSGPNTPSNNPSSSSKPVNNDIEEDAVDETSSLMSSTTPELVENVVASSVDTDRSHRIDIRGFSLLRSQSFWLLFTIMAILSGVGLMTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USU8</accession>
    <name>A0A7D5USU8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein RAD5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RAD5B_1</name>
        <name evidence="7" type="ORF">G6M90_00g023780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548178.1">
        <property type="nucleotide sequence ID" value="XM_014692692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USU8"/>
    <dbReference type="GeneID" id="26237622"/>
    <dbReference type="KEGG" id="mbrn:26237622"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="501"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI66077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1158" mass="128870" checksum="BADAE2DAF289CB2B" modified="2021-02-10" version="1">MDANGTFQSPQPPPWPSSETTVPLRGSRPGAEPAGQSATVQQSLNPNLAVAQGPVLQPSGPMPAWNPAALLQPSRRGFSATDLRNLPSGRPQPMYNHVANGHSRASPSVNDQMVFQFTSASDTSSNDHTSGSSTPTPPNGETSVSNANGVGLWIERMNNVQRRSNVPHPKRRKTEDPQDFAARASNMSIRSSSGMLGDYVRDRRQETDAGRLVPQTPTVDLTDGTDDDVMVLDDPKDEEVCYGMIKTSLNCSKVPSPKPGMQSLWGPGYNPGIKILLKRQSGERSLKIQACDHTREMIGLVELSCAAALTPLLDTNIRLRTDCRIPPHQKKPGEEPGQAISRAYNLDVVLYGPQRYARSIGALLSKHNLKLIAPHMVQKGIKVFNPHVSEWRPPPPKVYPTNAQGTYTSVANRTVEEIRSEVMGVFDSLKRNDDLPTMDPDARILTPLLKHQKQGLYFMATREKSLQEQSTEKGMVSFWRTKVNARGEKLYSNVITGQEQRAPPPETCGGILADMMGLGKTLSILSLVSSTIDESHKWEQVPIVQRPKMDPRLSSNGHSAMQTNFDPAAVTRHVKSTLVVCPLSTVTNWEEQMKQHVAPGGLSYHIYHGSNRIKDVDKLAEFDLVITTYGSVSNELGSRRKGKDGIYPLEEIGWFRIVLDEAHMIRESSTLQFKAMCRLQAERRWAVTGTPVQNRLDDLAALLSFLRLHPFDDRSKFNRYIVEPFKACDPEIVPKLRVLVDTITLRRLKDKIDLPKREDLVIRLNFSPEERSIYELFARNAQDRVKVLAGVKDGKALGGNTYIHILKAILRLRLLCAHGKDLLNEEDLAALRGMSAEMAIDIDDDDEDGPTLSHQKAHEMFSLMQDTNNDACIECSKKLNAGEGQNLDAEQQDDILGYMTPCFHVVCRNCCRSYRERAQQFLAPGQNTGPCLICGSHVRLEFVELRRDDVDAEHDGPAKTKAKDTKKRFDKYDGPHTKTKALVEDLLKSKAASQACPNEPPFKSVVFSGWTSHLDLIELALKPAGITFVRLDGSMTRMARTSAMEKFREDNTVEVILVSIMAGGLGLNLTAGNTVYVMEPQYNPAAEAQAIDRVHRLGQKRPVRTVRYIMLDSFEEKMLELQEKKMKLASLSMDGQSKALDKAEAARQKLMDLRSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USV3</accession>
    <name>A0A7D5USV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Importin beta-like protein KAP120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KAP120</name>
        <name evidence="6" type="ORF">G6M90_00g025140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548068.1">
        <property type="nucleotide sequence ID" value="XM_014692582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USV3"/>
    <dbReference type="GeneID" id="26237512"/>
    <dbReference type="KEGG" id="mbrn:26237512"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI65711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116940" checksum="B71CCBE69EDDBB10" modified="2021-02-10" version="1">MSFAIEVPGEANPLSLETLCHALQAATSNDFAQRQTAGQQLTSWEQTPGYYSSLQAVFLDKSIPTNVRFLAVIQLKNGIDKYWRLYAHVRNGIKPDEKTLIRSRLFQGTIDEEERNLALHNALAVAKVVRIDYPANWPDALSHTIGLLRSGKDGNQKHLYGTLQILLRVVKELGTARLRKSQTALQSVTPEIVYVLNDIYAEKTTLWLSFLSSNQGSGEDANVAMHNSLLSLKIIRRLIILGYERPHTDKSVEQFWTISQNQFGQFLNFVGQEPTIPPIYQDLVGKHLLQFTKLHIDMAEQHAASFSILPNSLHLVHAYWDLVSKFAEVFDSSGGIRQGSGDAGSSKAKVEGPLQERLALKGLLLLRACVRIAFQPVQTFKYRTPETKAEQEQSRNFIKTELLKDDLVIQMVNSIITHLFVFRRSDLEAWEEDPEEWEQQEQSEGNAFEWEVRPCAEKLFLDLLTNFKQLIIPPLLSYFQSAQSSQADIATKEAVYTAMGLAAAHVVNVFDFDSVLSSTIVNDAQQQGGLHKVLRRRIAILISQWAPVKLADTSRPLVYQIFQHFLNPNDETNDLVVQITAARQLRWIADELDFSVEAFLPYTSDVLSQLIQLIRNVAVDETKLAILESVRILVTRMEEQVSQFGDQLMSALPGVWENSGTEEYMIKQAVIAIFAALVMSMGDESQRYQNFMIPLLSEAARPGSDIHVHLIDESLELWNAILMQSKAPLAPEVISLAEMALPLLEYQPDTASQALTAVESYILIAPSAMLEDKLRRPTLAALSGTLNSKSREQVRLGTVCIEYLIRAATQLGGSNGISVIVQDMLETGFMNQIMTNIHDAWEAHQTTGPNRKISKLNTITEGDYLAILARIALAEPNMFVQMLTAFGSLEQVWSWLSAEWFSHLSSMDHQERQKLYLLGLTRLIELPSPMQELTLSKLQDYFDMWTNVTSEVQEGELGGHDTLVWGELEPSEYDTPKMIIERQTMAKDPVHSVPTFSFVSARLQDLVARVGGEAAFEEQWAVNVDKDVLERFGQLANAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USW6</accession>
    <name>A0A7D5USW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g006070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549899.2">
        <property type="nucleotide sequence ID" value="XM_014694413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USW6"/>
    <dbReference type="GeneID" id="26239343"/>
    <dbReference type="KEGG" id="mbrn:26239343"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="64" mass="7669" checksum="A3B7FE04E0308578" modified="2021-02-10" version="1">MAIGIKHSEDQIKDPPTSILQFFSFAINIKSEQPHRISHSTKLFHKRWTLLYVARETFWKDVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTP0</accession>
    <name>A0A7D5UTP0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LAC12_2</name>
        <name evidence="10" type="ORF">G6M90_00g040080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547358.1">
        <property type="nucleotide sequence ID" value="XM_014691872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTP0"/>
    <dbReference type="GeneID" id="26239921"/>
    <dbReference type="KEGG" id="mbrn:26239921"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="515" mass="57275" checksum="11DA5913B04EBD58" modified="2021-02-10" version="1">MAPSAAHTADGILPPIDLKAIRPFWKRRNGILLYFLLTSSLFTSAALGIDGSMTNGMQVLPTWQERFGHPTGSKLGFFGASNAIGGVIPFLTLSWMGDKFGRRIPTALGSLVIIIGVLVEFFATSLNMYIGGKMVLGFGSGLVQMTAAVLVTELSHPKERVQVTTFYNTSIVLGYVIGAWATYGCFRIPNQWSWRLPTLIQIVPSAYQLALIFFSPESPRWLVAKGRKEEAREILVKYHGECDPGSPVVAFEFAEIQEVIAKEAEQNMTWREFFSSVPNLKRIGLCFATAVFSQSSGNLLVSNYLTQILKDTGVNADKDITLVNGMVTLWQYMVALTVTVIIDKFKRRTFFLVGSGGVVVTFVVWTIAAQQYLEKNSLAAGRVVLACIFIFQAFYTFAWTNLVVTYPLEVVTYQMRAKTWAFVLLTIQVASIFGGYVNPIGLENIGWKFYIYYCVWVTIIFLVVYFFFVETAGPTLEELAYLFDGAEAKMNIMHATKGIEDSAAHMEEKPGQKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUC4</accession>
    <name>A0A7D5UUC4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ER membrane protein complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EMC7</name>
        <name evidence="10" type="ORF">G6M90_00g034590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546856.1">
        <property type="nucleotide sequence ID" value="XM_014691370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUC4"/>
    <dbReference type="GeneID" id="26239419"/>
    <dbReference type="KEGG" id="mbrn:26239419"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028865125" evidence="8">
        <location>
            <begin position="18"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="29"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="235" mass="25194" checksum="306D7D21E3E229CC" modified="2021-02-10" version="1">MRFPALAVPALAAPALTASITLYLPPVPNPFTLPASTHATLSTLGSAFSAPISALNTFVFHNVTPGSYLADIHCKTDGFRPLRIDVARDADGKETFQAWDTFRGNEWGNKGEALPVKDGSAGWGVEAKSLGKKMYFVDRPQFSVLSILKNPMILMGLVSMLIFFGMPKLMENMDPDLKAEFEARQREGPMAAMSGQQQNPLGNFDMAAFLAGSGKKEGGAGAGSVSDGRNEPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUQ3</accession>
    <name>A0A7D5UUQ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539739.1">
        <property type="nucleotide sequence ID" value="XM_014684253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUQ3"/>
    <dbReference type="GeneID" id="26247496"/>
    <dbReference type="KEGG" id="mbrn:26247496"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="486" mass="56189" checksum="EC995A2F395AF595" modified="2021-02-10" version="1">MEHIPDVQADHGAPNTFPLTAQQVEDTIRDFIDSINKAAVCDLASRHNGGRCCRIVDQRNGSFNICFFLLFDAHVTWVVRIPIEPVTRNAWAKVVSEVTTIRYIKHNTTIPIPEIYAYGKDTTLVKAASTPFILMEFIQGQQLHTRTVFHAAEHQRRNLYIGLIDTLAQLRKLEFSATGSLMPNPDNPDDESNPVLGPFLSMTVNKLERKLERPVLTEIFTSVNRFMDLHYHILSQTFQLPVEELDRRQAKMELFALESVSKEIPKHIKLQEPERPYILAHPDLRCGNIMVNDDFHILGIIDWEFTSTIPQQIYIPPPWITGHDPDTLLMVTGVPREQIWLEFRRVLEDLHKTSSGWTQLCQDWGLLHHDETQSKDFILELSPIVQILRHPSSLMDVYYSSIFLRLFGSETCRDAVVNEFFEQSENQAIAEQIELQIQKSERYTEYLRNNDLLIPDERSQQIQEFLKRAKALLQAGETRHGKEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UV39</accession>
    <name>A0A7D5UV39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CPYA_1</name>
        <name evidence="8" type="ORF">G6M90_00g050450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545150.1">
        <property type="nucleotide sequence ID" value="XM_014689664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UV39"/>
    <dbReference type="GeneID" id="26242491"/>
    <dbReference type="KEGG" id="mbrn:26242491"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029036257" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="487" mass="53764" checksum="77581474AD8D02F5" modified="2021-02-10" version="1">MRVSSSVLFLAAASTVVADLTKVKKASTYQEAIDRRPDSFWDHIVKGAEIQDASTKPGAHKRLDGELANYQLRVRQADPAALGVDKVKQLSGYLDEEQEDKHLFYWFFESRNDPAKDPVVLWLNGGPGCSSFIGLFEELGPATIPNEDLVPVDNPYSWNSNASVIFIDQPVNVGYSYGTKITGSSQAAAKDIYAMLTLFFHQFPEYAERDFFVTGESYAGHYIPAIGAELLSHNNSNINLKGLAIGNGLTDPYIQYLYYRPTACGQGGYPAVLSQSDCQAMENAEPECQRQIGVCYNDPSARVCRQATNYCNNFLLGIYQSGTNNSVYDITSPIGTGKTSYASQFLSSTKTKQALGVEASRAYEECNFDVYNDFVNNGDWMTPAHRVVPGILEKIPVLIYAGDIDYICNWLGNEAWTLALEWPGKSALNAARSQELHAKSGKNYGNVRAAQGLSLMQIYKAGHEVPQYEGEGSLDFLNRFMGGEWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVS8</accession>
    <name>A0A7D5UVS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g047280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544849.1">
        <property type="nucleotide sequence ID" value="XM_014689363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVS8"/>
    <dbReference type="GeneID" id="26242190"/>
    <dbReference type="KEGG" id="mbrn:26242190"/>
    <dbReference type="OrthoDB" id="5103320at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF33">
        <property type="entry name" value="MEMBRANE PROTEIN WSC4, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028885588" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="50050" checksum="EBC709E788382DC2" modified="2021-02-10" version="1">MRLSWGLVLGLALGASAGRIAPRQNDASTTGPSPAASSIGGGSEPTTPTSTSTSSSSSSSSISTSSSSAGGGDTTVFVTATVTSAGGGSTVSETTTVTASSVTTVTITTTDIATTTITMTDGETSTRTVFVTSTQTVNMKRRSVGNVLQFYGNGPAHVDAQPTAATTATGIPSRDLSPERIGIEKRAVVTSTVTVTVGGGGSATTVTQTVTKNVRSTTTTVVHTTSLITETFQANAKTTVTVTSTIVTKLTVVSTGVVESTSTPTSSPNPPNNNDNNGGLSTGAKAGIGVGAGVAGLAIIGALLWFFTRRRRSPKPDPDDLLGPSSEVPVGVGGGGSRPMSEGLASTPGSVPRRSPVLPNVQPEGYRGTAKGDGRAGYAKPEPYGAAYAPTRSTTNSSYPPRSGTLSPGDQLPRHPTPDTTTMASVSPLSARPQTAELGNDGAGARWHTSEAAEMASDNPAAAKWHSDNAHEIDSHAVMSHQSGPVYEMPTEHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWI9</accession>
    <name>A0A7D5UWI9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EGCSE</name>
        <name evidence="8" type="ORF">G6M90_00g033190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543248.1">
        <property type="nucleotide sequence ID" value="XM_014687762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWI9"/>
    <dbReference type="GeneID" id="26244049"/>
    <dbReference type="KEGG" id="mbrn:26244049"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF3">
        <property type="entry name" value="ENDOGLYCOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028832711" evidence="5">
        <location>
            <begin position="22"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="87"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="7">
        <location>
            <begin position="408"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="498" mass="54684" checksum="5391C4C7834EF42C" modified="2021-02-10" version="1">MYTHQVYAGVVALSLLGGGLAQDGAGWYAAHPGMARVQRVNQDTHQIVDEFGRARFFHGTNVVMKEPPWHRPAEWVPGVSSFGERDVRNMRDLGLNVVRLGHSWAGAEPVRGEYNETFLDIMRAQTSLAEAHGIYVLVDVHQDVLARQLCGHGVPDWFVKKDWVPAWERYPFPLKLSPFSVDTAGFPSPASLCGSVDWALSYTSVAVSNAFGRLYNNFDGLGDAFAAYWRKLAAGYAATANVVGYNLLNEPWVGDSWADPSLLVPGVADHKALEALWNRAATQIRAVDNDTLIWFEGATLDILSGFNNVPLGDGARSVHSYHYYKPPQLGSIADTLANRRRDSERLRTASVLTELTFWMGDDQQMRDLADAMEATDAAMVSWIGWAYENLYNGTSGRPYPELAGHYARAYPAAVAGVPRSFGFDEKSATFTLRFTADPAIDAPTEVILPPATFPGGYSVRISPEGSLLQHKPDERTLALFTSPGVKNATDVSVTITRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWZ1</accession>
    <name>A0A7D5UWZ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">15-hydroxyprostaglandin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HPGD_1</name>
        <name evidence="3" type="ORF">G6M90_00g055740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544168.1">
        <property type="nucleotide sequence ID" value="XM_014688682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWZ1"/>
    <dbReference type="GeneID" id="26242580"/>
    <dbReference type="KEGG" id="mbrn:26242580"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000643">
        <property type="entry name" value="Short chain dehydrogenase/reductase family oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="322" mass="34665" checksum="575220E1746529CA" modified="2021-02-10" version="1">MSHAIKGKTAIVTGAGSGINLAFAQQLLEGGCNVLIADLSLRLEAQRLVDAHTSPAEGRARAVYQHTDVTNWKHLERMFAEAEAQFGEIDIVCPGAGVYEPSFSSFWYPPGTPKSRDSVEGGRYASVDINLVHPIRTTQLALARFLKYKRKPRTVVIISSTNAQDTCLSTAIYDATKHATSGFVRAMSKIDQVHVRIAAVAPGIIKTPLFMENPDKPAMLDGDKDILVEPSEVATVMVCLIERDTICSKIDEARTGAQDIPIGSGTILEVTKNRVRAVHAYHDPGPSGPGAVGSNFEASEATTLALLCPGWGEPTIQKEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX88</accession>
    <name>A0A7D5UX88_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Equisetin cluster transcription factor eqxF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eqxF</name>
        <name evidence="6" type="ORF">G6M90_00g064190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540123.1">
        <property type="nucleotide sequence ID" value="XM_014684637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX88"/>
    <dbReference type="GeneID" id="26247159"/>
    <dbReference type="KEGG" id="mbrn:26247159"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF58">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI69215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="632" mass="70113" checksum="3B20697989BD6402" modified="2021-02-10" version="1">MQTPGSMLVTRDTSASSPAGGPSPASSVSQNHGGVAVNGLISPTTTVESPEPNQIITTDSTPAQNSTEDTASNQEGQRIVRKRKRNCLSCLRCHRLKVKCDKELPCGRCKSSGNGRECYYSYNKGPNGGKFPCPTAPAGGPIDPDSKKPQLAPWQITHKVRGSSHWRELMARIGSLTPISQSPLAKILEGVATNACLANFSLPGNFPFGTPGATKYYARDTITRLISGEKDNVEEYLGRYVDMLDVVNPVLDLSTFQEEVHRYWQDPNAVGLCWLAQFLMVLGLGCFTSGTDPPIAIEFMMAAEACIMQTPFMFRPTISTIRAFTLMVVAKQICNATCWAMDSSYTLMGHLVRLAFILGLPQERNDNDEELRDPVEKEIRRKLWLTILYLDIKVSMCTGMPPLTRPEELGGLKNMPHWRAPDSLQMVLYQGLPVVLNILAQMNSKRDPISYPDVLRYNAQLRELMGHANRVCQAPLQRITIDIFLRRCLMVMHRPFALHADGPTMFPESYWSSLECSLALLFHYRELWDPETPQPLDLVGRPFVLDIFSATLTTCVHMLRQDAPLSEAAATGCLIPPRQLILETLVSCVDIWAGEQEKSVCWRTGYHILKALMVILDAPGARAESPEAGQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY69</accession>
    <name>A0A7D5UY69_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">High osmolarity signaling protein MOS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MOS1</name>
        <name evidence="14" type="ORF">G6M90_00g061750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542696.1">
        <property type="nucleotide sequence ID" value="XM_014687210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY69"/>
    <dbReference type="SMR" id="A0A7D5UY69"/>
    <dbReference type="GeneID" id="26244645"/>
    <dbReference type="KEGG" id="mbrn:26244645"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="246"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI69797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="306" mass="33046" checksum="40D26B3302A3CFE9" modified="2021-02-10" version="1">MEHSRPYGGRKRMSLGNILGDPFALATISISLLAWFITFISCVIAQVQANKNKGLPDKDNPDGNFPPFAWWAVVYSLFLIVGVVIVVASDAIQTYHVAVTGYLAGGMVLVTSGVNSLVYSKNGAREAAAAGFILLSMVVIVWIFYFGSTPSSTPRAFLDSFALSKDSGAMHNQAMNGYGGTGRPETSNSVQPPQMYTSAQLNGFENPSPVGGASQAPTAPTMPTYGNNTMQPNNKSNDEEVLPPIDYPYQAKAIYSYEANPSDANEISFSKHEILDVSDVSGRWWQARRRGTNEIGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYD4</accession>
    <name>A0A7D5UYD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g079500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539922.1">
        <property type="nucleotide sequence ID" value="XM_014684436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYD4"/>
    <dbReference type="GeneID" id="26247260"/>
    <dbReference type="KEGG" id="mbrn:26247260"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="317" mass="35834" checksum="D96683DD2B21F31E" modified="2021-02-10" version="1">MSCVSSFKTPPSTSACTGPSPSTAQELSTTTGRYPMPYFAAPDRLPEPLPTDATVKCSSDVLKAGYGRRIVRVGQYFVVKYGVLVSLTEGENMLFVREACDISVPQVFALYSRIHPGGTKVSYIVMEYIQGKSLDSCWDTMSAADKSSASQQLRLMLDKLRSVPSPGYFGCIGRRPMEEGMFWTREEDGNDPGLISGPFDTEAQLNNALVEKYLYSSGMPSKSRFYRRIFPHVLRDHASVFCHGDLQRKNVLVGDDGNLSLIDWESAGWYPSYWEYASAMFACGNWRDDWHEYVASILDEYPNEYVWFDMMRRELWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UYN4</accession>
    <name>A0A7D5UYN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L18-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL18</name>
        <name evidence="5" type="ORF">G6M90_00g070330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540644.1">
        <property type="nucleotide sequence ID" value="XM_014685158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UYN4"/>
    <dbReference type="GeneID" id="26246517"/>
    <dbReference type="KEGG" id="mbrn:26246517"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="4">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="184" mass="20803" checksum="28F13E944B17C4BA" modified="2021-02-10" version="1">MGIDLNRHHVKGTHRENPKSDNVYLKLLVKLYRFLSRRTDANFNKVILRRLFMSKINRPPVSLSRIVGNINKEGEKRTVVVVGTVTDDNRLLTFPKVNVAALRFTATARARIVKAGGEAITLDQLALRAPTGSNTLTLRGPKNAREAVKHFGMGPHKHKKPHVVSKGRKFERARGRRRSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZC1</accession>
    <name>A0A7D5UZC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g066970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZC1"/>
    <dbReference type="GeneID" id="26247646"/>
    <dbReference type="KEGG" id="mbrn:26247646"/>
    <dbReference type="OrthoDB" id="4940644at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="159" mass="17396" checksum="F45E18B727867291" modified="2021-02-10" version="1">MAQSNKWAAELAAYNLDAAFVYGARHTISDKDYWQVEALNLLEAYLRQSQKDRPEAERWRNICVGVEALLKRQDIDTDEHRQSIDNDGYWAVEADCLQSHTARLESELLDGPLELGNTKATSGTINSSALALKPGKGSSADASVGSTLLETSTAKPCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0A0</accession>
    <name>A0A7D5V0A0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g067340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540493.1">
        <property type="nucleotide sequence ID" value="XM_014685007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0A0"/>
    <dbReference type="GeneID" id="26246600"/>
    <dbReference type="KEGG" id="mbrn:26246600"/>
    <dbReference type="OrthoDB" id="4936424at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1250">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.80">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035423">
        <property type="entry name" value="M60-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17291">
        <property type="entry name" value="M60-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="233"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="618" mass="69183" checksum="D17C9249DD593D73" modified="2021-02-10" version="1">MQTNRLDTLDMCYGNKQDPASLWSKEEYTGKNELRHANPGRVGQDVLDGQVPEEMAMTIRTEAKTALKSSQDSGGFYRGKPEIIWPEVWNEGPQKADKIVLESPDLRQWNLSITHVYASCPGTEPGSARIRCVWDNKDKDFYAWSAITLALGATSSSTIVLPLTLTSYVKDTGSVSLRQSDSKTVTHKWSGRVPPVYKQTDTSLFPQPRAMTVHAAPEAEQERARLRQRMKWADFQPTGFYLNPETPLIITASGIDTNPLKPVILVGTPALVHPDHRNELMPAQLEASKPLKNGVNTISSPSGGIIYIRYVERAGQGRRPITVSLGNTAQPFPLFRPGETTNNQWKAMLHATKVPFAEQSGNHVIITGLAADAKIYADKGQQQEALLYMYRDIIGAQDKISSLNTAEQSPRDKPSLLRPMVVQTKDGVNPNSAHYRAAIPSKLHQWVWWHPSVRWSWMIWHELGHHRQHTDTWSWRAVGQSTANIYSLAVGRSLKSSGRSLTEWYKAKQYLALAPDKKVFDNADVFTQLIMFEQVGVAFGGDGFYHEMHKRSRAGPTQATNADAKHYFMTLAAQIAKTNLSVYFTKWGLKPEPRTLKEMGKQPSPTKDYTTVPVYGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0G2</accession>
    <name>A0A7D5V0G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">homoisocitrate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lys12</name>
        <name evidence="14" type="ORF">G6M90_00g057800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-homoisocitrate + NAD(+) = 2-oxoadipate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:11900"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.87" evidence="12"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544360.1">
        <property type="nucleotide sequence ID" value="XM_014688874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0G2"/>
    <dbReference type="GeneID" id="26242772"/>
    <dbReference type="KEGG" id="mbrn:26242772"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000012">
        <property type="entry name" value="Homoisocitrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="7"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="356" mass="38064" checksum="C8D9C64016DB54D5" modified="2021-02-10" version="1">MSVRTLRIGLIPGDGIGKEVIPAGRRVLEALPSYLNLNFEFVNLKAGFEAFEQTGTALPEATVNVLRNECDGALFGAVSSPTHAVKGYSSPIVALRKRLDLYANVRPVKTVMTAPKPIDMVIVRENTEDLYVKQEKTFDGPDGKVAEAIKRISEKASLRIAAMAGEIAVRRDRIRQSGAASIHKKPLVTITHKSNVLSQTDGLFREASKRALADPKFATVKVEEQIVDSMVYKLFRQPEDYDVIVAPNLYGDILSDGAAALVGSLGLVPSANVGEGFAIGEPCHGSAPDIMGKGVANPIATLRSAALMLEFLDEPAAAAKIYAAVDANLEEGELLSPDLGGSATTEQVVEDILKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0H4</accession>
    <name>A0A7D5V0H4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-binding cassette transporter abc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">abc2</name>
        <name evidence="17" type="ORF">G6M90_00g086260</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541183.1">
        <property type="nucleotide sequence ID" value="XM_014685697.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7D5V0H4"/>
    <dbReference type="GeneID" id="26246172"/>
    <dbReference type="KEGG" id="mbrn:26246172"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000450">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1104"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1132"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1217"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="320"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="647"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1314"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="871"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI71896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1555" mass="173403" checksum="842E932FE386D32A" modified="2021-02-10" version="1">MDPLDLMDPYSEQQVRLLSGSFTGLRPLQRLGGNYFSVSAFQQPLCGNEEGWGPISKYRYDFTPCFIDVWLATVSVYALVLGPVALWWLLTKKKPMEEGASKNAHFYIKQSLLVFLIADVVVQLVIQILGMPGIWYGDFRVLTTLLTILSLFVIFSIQWIEHSRLRHANGVVLFYWLLLLISLTVKLRSLISQQVYEGNLPYFIAYCIGFGFAVVEFLVEWLWPRQHVPSGYEAIFEDEECPVEYATVFSRLTFSWMTPMMQYGYKVFLTENDLWGLAKPDQTKTTGAAFEKAWAHELSHRPKSPSLWLAMFRAYGGPYAVAALFKIGNDIAQYIQPQLLRLLLTWVKSYNPEYGVIAEPVIKGAAIALAMFSCAVFQTTMVHQYFQLSFVTGMRIKGGLASTIYRKSLRLSNEGRSTKTTGDIVNYMAVDAQRLQDLTQFLQQAWSAPFQIIICMISLYNLVGWSMMAGIVVMIIMMPAQGWVARIMKNLQKDQMKNKDARSRLINEIITNMKSIKLYAWGAAFMNKLNYVRNEQELKNLRRIGATQAFANFTWNTAPFFVSCSTFTVFVLTQDRPLTTDIIFPALALFNLLTFPLAVLPMVITSIVEASVAIGRLTDFLTAEELQSDSVTVKPAPKEMGEETVLIRNGTFSWNRHEPKEVLKDIDFTAYKGELTCVVGRVGAGKSSFLQSILGDLWKVKGSAEVRGTVAYASQQTWILNATVKENIVFGYKYDSEFYEKTIKACALLDDFAQLPDGDETVVGERGISLSGGQKARVSLARSVYARADIYLLDDVLSAVDSHVGRHIIDSVLGPRGLLSTKTRILATNSIPVLKQASFITMLKDGEVAEKGTYSQLIAKKGLVADLLRTAGQDSNNGSGSSSPPSSETSTIIEGEPSFTQNKEEVEEALEDVPEMEPIKGATPMGKKTRSSSMATLRRASTASFRGPRGKLTDEELASASRTKQTKEFVEQGKVKWSVYGEYAKENNLVAVGIYIFALLASQSASIGGSVWLKEWSEHNEKTGSNDSIGKYIGIYFAFGIGSSLLTVGQTLILWIFCSIEASRKLHERMANAIFRSPMSFFDTTPAGRILNRFSSDIYRVDEVLARVFNMLFVNVARSCFTLGVISFSTPAFIALIVPLALTYYWIQRYYLRTSRELKRLDSVTRSPVYAHFQESLGGITTIRAFRQQQRFELENEWRVDANLRAYFPSISANRWLAVRLEFIGAVVILAAAGLAIISVSNHNGLTEGTVGLAMSYALQITTSLNWIVRQTVEVETNIVSVERVLEYARLPSEAPEIIPENRPPIAWPAKGEVDFKNYSTRYREGLDLVLKNVNLDIKSHEKIGVVGRTGAGKSSLTLALFRLIEPATGHIGIDNLNTSTIGLLDLRRRLAIIPQDAALFEGTVRDNLDPGHVHDDTELWSVLDHARLKEQVANMDGGLEAKINEGGSNLSQGQRQLVSLARAMLTPSNILVLDEATAAVDVETDAMLQATLRSPLFSNRTIITVAHRLNTILDSDRVVVLDKGEVVEFDTPGELFKKQGVFYGLMKQAGLEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V151</accession>
    <name>A0A7D5V151_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UTP25</name>
        <name evidence="14" type="ORF">G6M90_00g075420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545556.2">
        <property type="nucleotide sequence ID" value="XM_014690070.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V151"/>
    <dbReference type="GeneID" id="26241589"/>
    <dbReference type="KEGG" id="mbrn:26241589"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
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    </dbReference>
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                <person name="Kortsinoglou A."/>
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        </source>
    </evidence>
    <sequence length="1118" mass="125269" checksum="5EC2970E5A2CE1F6" modified="2021-02-10" version="1">MFQRIRGAIDRTIAEEQARQKAVDSETLSRSGSTSSRRSDANPAGRRPRQKKPSADITDSAAPNPDPAVFEAAFVIDDSDEPSRSGTPAPPPPPEKDNIDGGRTSAPKGEEGDKSLANGANADKEHADDKSKEDGDAPAPAELSPEIKQRLRKLEKLESTYPELLRSYRVAHKRATAIEPFEKALRENTPLTSINDPDSLVEYLNQLNLRGDMVMDELKKVSADKEELKKKHAETEEKLKKAQSELETLKSGKSIEAAAESSGRKSLEPPARTSVDVAAEKVKSPVASVISMFSPKQKAQDAHHGKSESEDFFSYDEEIPQLQAEVASKTEEIEQLKGKVEDLEKELSIAKENSAGLAENLEKTSKALSESREASGPQASLRKQLDERNQEIRALTEKLDAAQSELKNLEGRAERDKKEHASRVEDVEASLAESDKKASELDAELTKANNAKSISKKLIDDLSTQIESLKKDKSESLAKIEELTKKLDSPATSQPTTTQPTPATPPAAGGSKKKNNKKKKGKGAAGGATTAAPPPAEEEDTKEATEKPDSAALSSLEAEIAKLKTEVEEKDQQIEKLSKRRKTEEDLREEIENLQENLVNIGQDHVEAKEKIKELEQEKTKLKEHIAELEAQVGSSKSNATSNAKVQGDLDALRKEYDDLRDKSTTLQSDLGAAQQLAQTRFKDLTDLREVLQKAQPELKSLRQESAELKTTKEELAAKIKELKTAEKRESELKRDVSKAQQLVADGEKEIKSLQEKLKSEESNKQKAEDGKRTAEKDLRRAEADKIELSAKAEKTERELQRAQDELNKLRPRVKELEEQMHKLRREKAASQEEAEFKSQQYTNAQGLLTSMRDQTTELSVQLKESKSQAESLEEELVEVQRLLQERTREGETMRRLLADVDERADTKVREMRGRMEAAIEERERIEDESSTLARRKARESEELKTKIRELEREVKSLASERDELEERQREWKRRRDELEAIESKASAETEEMRTTVSQLRSALDTSETQLRDGEKQRGDLRKMLDDSRQRYEKLARDLKTAQSKLVAGSSRSSMDSTRSGNGGNGDTMYLKTILLQFLEQKDGRLRAQLVPVLGKLLKFDKSDEQKWLKAVQHIEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1F3</accession>
    <name>A0A7D5V1F3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g083880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987410.1">
        <property type="nucleotide sequence ID" value="XM_066131236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1F3"/>
    <dbReference type="GeneID" id="26243782"/>
    <dbReference type="KEGG" id="mbrn:26243782"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="244" mass="26407" checksum="B309F66DBACDE08E" modified="2021-02-10" version="1">MKIRPATVDDVPAVARIVLSALANEAPWKAFLPRMAQADAVHIEYCEAILRSYLEPANKNSWLVLVVEISATEAKVHSGPIVVSVAVWDTSAGLGQGLGAGQRNAVAAVNAQPTRQLDDKAPAKLAALCQATVDGRRRHFSNHIPYVFLHLLATRPDYQRKGYGKALCTSGINLARQKHASVCVQTASRGYILFSGLGFVDEGPVALPAESEAEDILIKAMVLDSQLIQRRGSLFDSLMRYFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V204</accession>
    <name>A0A7D5V204_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g080950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539445.1">
        <property type="nucleotide sequence ID" value="XM_014683959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V204"/>
    <dbReference type="GeneID" id="26247764"/>
    <dbReference type="KEGG" id="mbrn:26247764"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="330" mass="37245" checksum="D5649BB83DD87502" modified="2021-02-10" version="1">MTSSSDHFSHEVIRLRTNYQDKRQRSNLFPPTGLPILDMETVPGERPSMRFWHDDGTEVGRFVHLFDMPGKLSGQILRLERNLPPVGGHFEIEGDHFRSLETCPNLPQPIPDDFEDIQDLVMQLPLVHVDPSKHFLKKGKYRSEIENLLTCQGGSCPGSILSNHLVRLLGRSSDGQLVFEKLATRAILARFSSLAIYKRWILHIIDGLACLHDFGIVHRDLHIGNCLFAQDGSRLVICDLESRWGLRAAPEIAFSGGLDSGWTTRSDIYDIGNYIKCMVYANAPIASQVEWPVPEPLRAVVEACMHEEPNKRPTLLALRQMVEALPVHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V226</accession>
    <name>A0A7D5V226_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GSP1</name>
        <name evidence="9" type="ORF">G6M90_00g098030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546540.1">
        <property type="nucleotide sequence ID" value="XM_014691054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V226"/>
    <dbReference type="GeneID" id="26240963"/>
    <dbReference type="KEGG" id="mbrn:26240963"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="216" mass="24363" checksum="586F5A6D87C96BAB" modified="2021-02-10" version="1">MAEQQTPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVDVHPLGFTTNFGPIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLEFVAAPALAPPTAQVDEALMEEYRKEMETAAAQPLPGELSDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V274</accession>
    <name>A0A7D5V274_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Non-reducing polyketide synthase PKS16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PKS16</name>
        <name evidence="9" type="ORF">G6M90_00g081310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543370.1">
        <property type="nucleotide sequence ID" value="XM_014687884.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26243547"/>
    <dbReference type="KEGG" id="mbrn:26243547"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="368"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1288"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1641"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1288"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1439"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI72191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1715" mass="186130" checksum="06C25C4CCED384AE" modified="2021-02-10" version="1">MKLRVANFLLFGDQTVEKLPAIRHLVSHGSSSPLVQRFLREVCDAVQLQVSKLPQHSEQRSNIGNFDSILRLAENNARLEEPNEIIATVLMNIARLGELILYAEQDPTVLASKGNRNCILGFCTGEVAAAVAAVAQDTNELVELGVEVTHIIFRMARELNRRSLMVDRTNGPWARTILGISVDRVREILQDFHENQSIPRARQVCIGFVSDGWLTLFGPPTTLQRLLEWSAELEDAPQIDTDARGGVHMETLPEVDPDRILGSSPWLDRAPVHTATIISPYTCKPRQQKTLRGLLEEIIADVGQRTLNLATSMNAALELAQADKIRLVMPGYTSHDVYFQKLLQKRGIEYSVMSHGDHLSSGPSRQGSGLVAVVGMSGRFPGSGDINAFWEGLLEGKRYIQEIPNTRFDLEQWYDATGKQKNSTLARTGAFLDKPGMFDNRLFDMSPREAMQTDVQHRLLMTTSYEALEMSGYYPDGTLSTNKDRVASFFGQTSDDWREVVVHQGVDIYFATGSCRAFGPGRLHHHFKWGGPSYSVDSACSSSIAAVGLACSALLGRECDMAVAGGGSLLLSPSPFSGLSRGGFLSAHGGCQTFHDNADGYVRGEGVGVVVLKRLEDALDDQDNILGVVRGSGRNYSSDASSMMHPSANAQKKLYCDVLEQSGVDANSISYVEMHGTGTQAGDFMEMSSVLSTFAEKRGSDNPLIVGALKANIGHGEAAAGVCALIKTLMMLQSRQIPPQPDLPGPINHRFPDLAARNVYIAARNMRLEASPVAKGTLRVFLNSFDASGGNSCLLLEEAPPRAVKDADPRGHHVVTLSARSQKSLIGIKERYLAHLRQHPGTKLADLAYSTSARRIHGLLRYAIAASSIDEVVQCLETDLAQGKTPRQPPATPTVVFTFTGQGAHYVGMGANLWETSATFRNTLHDYQTMASAQGLPQFLHLITDSSTPAPQSGPDTVQVQLAMVSLELALAKLWRSWGIQPAMVLGHSLGEYAALCVAGVLSVSDTLYLVAKRAQIMAGALTPHEYGMLAVNLSVADTREVLSSGEHTSCAVACINAPKMTVVSGLRSKLDDLQDQLKSDGTRCTPLSVPYGFHSSQLDPILGQFEEACQGVTFSAPNVPVVSTLLATTVREEGTFSPEYLARQAREPVDFVGALGAVQEHKLPSLTFLEIGPDPVCSGLVNATLGADEAASRCVASMHRGKANWASISCSLRDLYTAGAAIDWPAHHRDFKSSVSLLDLPKYSFDEKEFWASFPDRDLQTIGEVQTKHSQPPAIVPSVQGYCTTTLQRITRETIEPDGLSVTFSSDLADQHLRAAVRGHAVADVEICSSSLLLDMALSAAQYAYMKHSPGQKMPVPLTVRNCYFHRGVVLTDKAQTVEVTVTLTSSAKTADIRYHCRTPDEYYEVGACQVVLKPASKPDQAGFLVRSRMAALKASASHRLGRRAVYRLFDNVVRYSEQYQGLDSVHLSEDMQDAVAEINMAHVPAAGGHYLHHPFLLDSIVHLSGFLVNNGLRYSSEWACLSTGFDEWHLLKPLDPTTVYTSYTFMEDSRSTSNLVTGDVYVYDGEELVSVLTGLQFQKMKRTALTHLLSPPTVGSMAAKPSTCMPTKAQTELLPAQARVVGSPVPTPPATASVDDGEGEKFDLVNTLFSIIAREVGVEPSDLEGDVNLANLGIDSLMAITIISVMQQETGVELPGTFFLDNATTTAVIAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V298</accession>
    <name>A0A7D5V298_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GOS1</name>
        <name evidence="12" type="ORF">G6M90_00g100230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987535.1">
        <property type="nucleotide sequence ID" value="XM_066131572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V298"/>
    <dbReference type="GeneID" id="26240749"/>
    <dbReference type="KEGG" id="mbrn:26240749"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="228" mass="25899" checksum="82BFE13B00CCAF8A" modified="2021-02-10" version="1">MAASASSAGWAQLRQQARSLETQTENLFHTYSQFSSAVNIPPKPSEEERNTEAKIEELLEKRDSTISQLARLFDSETTLTNSGVKQNNLSLLRDKLSSHRRDLNRLRGTLQQARDRANLLTNVQSDIDNFRANNPETAEAEYMLEERSRIDNSHNVADSVLSQAYAVRENFLLQRESLANINRRITMAASKVPGINGLITRISARKRRDGIIMGSFIAFCFLIFFWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2H4</accession>
    <name>A0A7D5V2H4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g105310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541518.1">
        <property type="nucleotide sequence ID" value="XM_014686032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2H4"/>
    <dbReference type="GeneID" id="26245768"/>
    <dbReference type="KEGG" id="mbrn:26245768"/>
    <dbReference type="OrthoDB" id="5599852at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="369"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="813" mass="90014" checksum="680BDCFAA9D55C91" modified="2021-02-10" version="1">MASAITWKRLLPHLSSFFGGFVMPSEHRQAQMADAWVNHTGESIRGLVDSIPILGHIDGIVHFAMGETEEGIHAEEQATRTIFVLGGGALGGSGGAMAGGALADAGLTGIESLRHHRYDPQGYFAVGTNIYHDFDDIIHRQNLTVEDVDRSLDNLQDDLFDLQVLGLTDGLPAAGTKGKIYRVEGKSIVKDGDKFFAGDNQRIFNYQGNVVAREQLPDLRPIEELANKPGPEIPEGDPTQNEIPGKGKGKGKGKGKGQGNQGPDNLEQELRTFNRIGIDGKLFKDNGKVIFLNFGQRDRMLGYYAQKLIDHRTLVEKYRATLEAERPGGSKTAVTEKTHDIRVKSFKVMTRDLEQTEKDAITEQEKKVFRDAEAKVRKAEAAVTKAQAQIDKAEGPQGSNQPDIDIQKARADLEAAKADLEKANAEFEKAPKDKGVLVVDVKAPRQYGLQNWRYTPIFEKVIPGTVDVNTPWIASLPTPILKLIHDNPVALGKILTFKYARTASGTGAQSANHLFPKNLQYVKQDDEISMEAVTPSKLLHCRHVKQKIHSFQDGSDDWIEHYEYLVKFDENSDPEWYPADLISPDLRQKFYDGVVKSAKPIANFKGGKDGKLFVQYEDGTEGTVDNTQVFWQEFDPSEQEQLDPREIDSILYHAQNTDTRFDGRFHLKKDDEFPLANGAGAVEWKSASGKPMYLGSAIDFHGTVHPCMVVADEVPHCVGTFGGRAEPHQGSYDLLPFNPDIMEWVDSYAGRIPEGREGVVGGYENNRQPLYHAVTNVNGHWWVGKAGPQFNGSLVPVGGEEMGSGESYILVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4I4</accession>
    <name>A0A7D5V4I4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane protein PTM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PTM1</name>
        <name evidence="12" type="ORF">G6M90_00g088210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987504.1">
        <property type="nucleotide sequence ID" value="XM_066131324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4I4"/>
    <dbReference type="GeneID" id="26244808"/>
    <dbReference type="KEGG" id="mbrn:26244808"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028924205" evidence="9">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="181"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="536" mass="60323" checksum="018D7A13F8341F46" modified="2021-02-10" version="1">MRLFLGLLALALSFRTTLAHEVAIDDTQANHQYCSGMYSRQTWGGPVDPFILVKFFNSSIPEGTDPIVSLIIFQWRDSSLVGVPDPDGQRRLPICTDEFVKSGHCNTTDIGEFVVSHNATEKSNALILTKAVHLKDAGPVHYSLKKTGYYCVVTQGYTIDKYNAVVEFRNAYGELQATQIPKLPFYGAMSIIYALMAGYWGFLYYQHRHDILAVQNYITAILVFLVVEMLITWGYYDFQNNGGSGVGSKAFLIVVGILNAARNSFSFFLLLIVCMGYGVVKHTLGRTMIYVRWLAAAHFVFGLVYSITSLVVSPESAGPFVLLIVLPLAGTLTAFYVWTLNSLNLTLKDLRERKQHAKEAMYRKLWWSILISIIVIFAFFFFTSFTFASINDPDFVPNHWKSRWFVLDGWLNIVYFVDVAFVAYIWRPTANNRRFAMSDEIAQDDDGNFEIGDIGVPDDWDDDEEAEAGKNQPHPPPVTGITSSAPTRPDRHQQNSTRSIPRESIDGETIFAVGEDGDRFSDDGSDEENAKLVNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4M2</accession>
    <name>A0A7D5V4M2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g111280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987861.1">
        <property type="nucleotide sequence ID" value="XM_066131825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4M2"/>
    <dbReference type="GeneID" id="90968256"/>
    <dbReference type="KEGG" id="mbrn:90968256"/>
    <dbReference type="OrthoDB" id="5139786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028994928" evidence="2">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="91" mass="10218" checksum="465523580DDA4B7A" modified="2021-02-10" version="1">MKLSATSLLVTFATLSGVLAQTCMCPEVPSMGQPMKLARKIELWATECTYNLAYGEKDYHLRCNFHRNHQKPTEEEAKASGAKWKVLATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4N7</accession>
    <name>A0A7D5V4N7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g112220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014684805.2"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="67370" checksum="ED9B6F80BB44BC53" modified="2021-02-10" version="1">MDSVHDAILDVEGRLDLGDAYDNAFGIQTKALPQGYRLIYREQPVYSMEDEPWSGGKPFMMKFRDKSGLLKDRNLIELVQYIMQTRLRVANRIVQDEWEIDGRQLIRALHAPDQPGKNISSFEDQMQRLPMAPTKMNKELVRTHLQLLSRFKASLDGSPRPKNRFMKHWIPYSIQDRLVLHIVLCTTASFLHETGRLPKVLLHIHRATAAQMLNEYISSPTLCTSDSAMLAVMQLILTSWYWSSTEELHAHMTGFKKMIQLRGGCQNLGMEGFTSKIALLNDAVIALCHDTQSVMFGQPGFEFDDPFRVPLQVNFNSPFLFNCPPFLIPSSSLRLHVKTAEILDSMRRLLQAVVELPDDTDDAQLNTVHVMAASMVAYLGQLPDQVVLESDGGRDLASDMSTGQKRKREEFDDSAMSTRRLSVADSVGGRSCDDPPDMVYLCVRLTALIWARAIFERIPTREVCSETEFIRIWSFAWAAGLDRWSSLSGIYAWMNIAIAPLCHATIHARMVKTLTVTTFTYMGTENWHVAAEIASAALKVQAWLRKGKETKPSGAVSGAFGGEKAIEDFGFAFKENMPDLPDHRYENQVREAEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4S2</accession>
    <name>A0A7D5V4S2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g094870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540848.1">
        <property type="nucleotide sequence ID" value="XM_014685362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4S2"/>
    <dbReference type="GeneID" id="26246461"/>
    <dbReference type="KEGG" id="mbrn:26246461"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="241" mass="26130" checksum="BEC6749E5BD1337D" modified="2021-02-10" version="1">MPFRLAVLECDTPVPSVEKERGSYGAIFETLLSKGTSVDFRLLKYDVVRQHTYPSTGDVDGILITGSKHTAFADDAWIVQLVSYIRDVLNTSRTPVVGICFGHQVIARALGATTAVARGGWEVSVSSVDLSPDGQKLFGASSLNLHQMHRDEVASVPEGLVCLGSSARCPVQGMYKRKAVLSLQAHPEFDGFIMEQILRARRDQGIFGEEMFGEAVGRAGDAHDGTLVAGKIWDFFLDAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4T3</accession>
    <name>A0A7D5V4T3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mrp-9</name>
        <name evidence="7" type="ORF">G6M90_00g096390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987544.1">
        <property type="nucleotide sequence ID" value="XM_066131509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4T3"/>
    <dbReference type="GeneID" id="26241118"/>
    <dbReference type="KEGG" id="mbrn:26241118"/>
    <dbReference type="OrthoDB" id="10254627at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI72792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="307" mass="34448" checksum="507C48C600E81612" modified="2021-02-10" version="1">MATFTNGMRHFRYPRQLASPQWHHHQTWRLPAPLCIRAINTAARNDDATATSLVESVQIPYQGVTHARTVPATPSYFSREPQFNDLYIRISNLLTRYHHLPTVSPGEAPQVPWTKLEEMRAQMGEPIKAMHYQKVIRVAKRLNLIEPSLRPAEVKIALQEFARDINPFLNMPNPITIDRFGRAVGVGKRKASTARAFVVEGTGEVLVNGKPLSEAFGRVHDRESAVWALTATERLDKYNVWVLVEGGGTTGQAEAITLAVAKALVAHEPALKTALRKAGCITRDPRTVERKKHGHVKARKMPAWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5N7</accession>
    <name>A0A7D5V5N7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g102480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987752.1">
        <property type="nucleotide sequence ID" value="XM_066131600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5N7"/>
    <dbReference type="GeneID" id="90968182"/>
    <dbReference type="KEGG" id="mbrn:90968182"/>
    <dbReference type="OrthoDB" id="3443409at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="54" mass="5973" checksum="AC11F4B66AFE2A4B" modified="2021-02-10" version="1">MCNFTKNYYIYTSCTDPGAHFCSTSTDGSKDRSCPMGPHERFIVIPESCPLCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YMI9</accession>
    <name>A0A7D5YMI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g008490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549659.1">
        <property type="nucleotide sequence ID" value="XM_014694173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YMI9"/>
    <dbReference type="GeneID" id="26239103"/>
    <dbReference type="KEGG" id="mbrn:26239103"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="108"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="407" mass="44244" checksum="252AC2D5E1F9E385" modified="2021-02-10" version="1">MPQFNYEYRASRTIEYAVLTAAACLSIYWYLQPVLSPGDPVKPTRVICSKARQAAKLASADSTRASSLAPRKLAPSYAPGVFPGGRDVETAYGTIKVFEWGPEDGEKVLLLHGIGTPCVALGDMAREFVRKGCRVMLFDLFGRGYSDAPSDLPYDDRLYTSQILLVLASSRIPWTGSSSFHIVGYSLGGALAAAFAAYHANLLRSATLICPGGLVRPSHVSLKSRILYSEGLLPSWLVNGLARRRLEPRPGTASADIPDPSVNTVDGDDSQDVDFDQVPVCAGDASGPKVGDVVRWQLRNNAGFVPAYMSTIRNAPIYGQHEGVWRRLSEQLALRREDEQVPGLEGGRICLILAERDPIVVKEEWIADSFAVLGEEAVDIRVLKGGHEIAISKGKEVADVAMAAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YPE1</accession>
    <name>A0A7D5YPE1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPC3</name>
        <name evidence="10" type="ORF">G6M90_00g003480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542004.1">
        <property type="nucleotide sequence ID" value="XM_014686518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YPE1"/>
    <dbReference type="GeneID" id="26245035"/>
    <dbReference type="KEGG" id="mbrn:26245035"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI64682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="225" mass="25159" checksum="D2DB2EB502211EDD" modified="2021-02-10" version="1">MHSSFTRIQNVFGFFTTVACVLAGFIAATDLLAARNPSGTLIPTNIQVVKGRPHYYSSKKEEYAIIKFSLDADLSSLFTWNTKQLFVYVTADWPSAEGQNATNSAVIWDSIITNPSADHLQNIGPIAMKKLKRSAEGKTIDPSRGLLKLNNQRPKYQITHPSGKIASVNDVTLKLHYNVQPWVGLLTWNMDKVIGWWFPMEKGVSEKFEFPAVKTKDAKKKAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YQK5</accession>
    <name>A0A7D5YQK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">tbg</name>
        <name evidence="18" type="ORF">G6M90_00g011180</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549402.1">
        <property type="nucleotide sequence ID" value="XM_014693916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YQK5"/>
    <dbReference type="GeneID" id="26238846"/>
    <dbReference type="KEGG" id="mbrn:26238846"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI65862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="462" mass="51473" checksum="29F42F3A8F7E4CFD" modified="2021-02-10" version="1">MPREIITIQAGQCGNSIGSQFWQQLCLEHGISQDGNLEDFATEGGDRKDVFYYQSDDTRYIPRAILIDLEPRVINGIQTGPYKNIYNPENFYVGKNGVGAANNWGDGYQSGEAVCEDIMEMIDREADGSDSLEGFMMLHSIAGGTGSGLGSFLLERLNDRFPKKIIQTYSVFPDTTNSGDVVVHPYNSILSMRRLTQNADSVVVLDNGALSHIAADRLHVQEPSFGQTNQLVATVMSASTTTLRYPGYMHNDLVSILASLIPTPRCHFLMTAYTPFTGDQVEQAKTVRKTTVLDVMRRLLQPKNRMVSTVPGKKSCYISILNVIQGEVDPTDVHKSLLRIRERRLATFIPWGPASIQVALTKRSPYIPMSHRVSGLMLANHTSIATLFKRIVRQYDGMRKRNAFMEGYKKTAPFSENLNEFDEAREVVADLIAEYEAAEDADYLSPDNGEKATSAETDRRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YRS2</accession>
    <name>A0A7D5YRS2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g058460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544422.1">
        <property type="nucleotide sequence ID" value="XM_014688936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YRS2"/>
    <dbReference type="GeneID" id="26242834"/>
    <dbReference type="KEGG" id="mbrn:26242834"/>
    <dbReference type="OrthoDB" id="2117996at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="204" mass="21519" checksum="48E0891E37BC3605" modified="2021-02-10" version="1">MRPQNVIAPLVIVLQGHAAVAVPIFGALGNMVDSFLSPLTGAVGGGSGSGQAPTSEQIDTAARAWRNDTGTVSNFLSNAESMDPQELQRQGKIALDAENDELLHKAVLDRMFLNGTAAARDAGVADANDVLVNQDTFQFIVDGLTLMSKRGSTMKPDEVKTLVKAMNQDRCPHVLPAIDKYMAAAQGAVPGGDKSLKAYRPTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT96</accession>
    <name>A0A7D5YT96_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g064260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540116.1">
        <property type="nucleotide sequence ID" value="XM_014684630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT96"/>
    <dbReference type="GeneID" id="26247152"/>
    <dbReference type="KEGG" id="mbrn:26247152"/>
    <dbReference type="OrthoDB" id="4937312at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="352" mass="38873" checksum="DCDBF2EDED6AD85D" modified="2021-02-10" version="1">MPATASDLEEAFRPVNEWDSKIAAKLTEIWVKDSDTWTERNRIEFKSLCADARITRATTTPSSHKIHRKIQGRKATAAEYTILSVMFGNRAVNRLSWGAQFARQKTILPVEIGVVTQDVRRVLRETWKSPKTEQTPKPEEPEPGIQMSGGLGQPKATDHNGPEPQPPHEKVHEARPVLAGGDPQSQADKSTVGNVGDTNGSSRTTARGGNKASAGLDGRDNIPAGRRTRPRNSGRNIDPDNPNENEATDERAQTETRKANQTSRKRKPGPAKGPSTKKQRKTAGQQKDPWDTIQNAKPTEGLKANIKKVEARCVAQEARMAKLEEVIFDIRDDLKMLRQQIDSLARYLAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTK5</accession>
    <name>A0A7D5YTK5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549844.2">
        <property type="nucleotide sequence ID" value="XM_014694358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTK5"/>
    <dbReference type="GeneID" id="26239288"/>
    <dbReference type="KEGG" id="mbrn:26239288"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="79" mass="8390" checksum="DCCA87FB35A65A3A" modified="2021-02-10" version="1">MDFVKKAAEGIKGNSGEKKDQAAQGQGGEQQDYVDKAFGMAASKSGHNIDRNTQEKITDAGRSAYEKATGSKVNPKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTM2</accession>
    <name>A0A7D5YTM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542620.1">
        <property type="nucleotide sequence ID" value="XM_014687134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YTM2"/>
    <dbReference type="GeneID" id="26244569"/>
    <dbReference type="KEGG" id="mbrn:26244569"/>
    <dbReference type="OrthoDB" id="3499148at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="396" mass="43833" checksum="34429BF71502BD26" modified="2021-02-10" version="1">MDDSYDGCARLDAAEPGPELNQGIEEPVEIFRKYLTSEWTRKKTPYGLDAALAKAADSESDATERVFLSTGFTAWLAYFLASTGEGHYEGRYAQLQAIAAFNQLPVEERKAAAKRVAETVPHDTVRHAIGKMLQEPKRRRELPIYFYIPSLTRESGLLSPTGDHESRIQSYSTSPTHSISSSAGLLPSPTQRDTTANLDNSQTDISLTSDLQQQVLSHASLQGTADIFPEYMSGAIRRDLMESDGSSCWRAAVTMTFPYLGKVDCLMSLAIRETKVEHSAMALFNVHVDVESAVQARQVVLQHGVRLTPNPEITLQGVRDEAIQNLLGLEIYEAIKSSRVFQEELQQGTRATRCVSMIIPGNPNIGAVINLNLGLKEGSRIRNKLYRRFASKDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUF0</accession>
    <name>A0A7D5YUF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TAF9</name>
        <name evidence="7" type="ORF">G6M90_00g059220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544495.1">
        <property type="nucleotide sequence ID" value="XM_014689009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUF0"/>
    <dbReference type="GeneID" id="26242907"/>
    <dbReference type="KEGG" id="mbrn:26242907"/>
    <dbReference type="OrthoDB" id="4941311at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="209"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI69341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="248" mass="25781" checksum="741F27A5A8539B90" modified="2021-02-10" version="1">MASSQPQTNGVTAPANTSSQTAPNTQSTTAAPAGAPQTPAQPPGASDPRPRDARLIELLLTSQGVTAYEQRVPLLLLDFAYRHTSSILSDALHLSGDPYVTQAGSKPSAASGASALAAGDAPITANGVKLAIGARLGYQFRGGSSGGGISKDYMQELARERNKVALPRIVPNEWGVRLPSERFVLSGTSWGLKDMWDEAGDDDEEEEQGGDAMEGIEAPEPEDVGGDGVEGGTVDDVFGDDVDQEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUN6</accession>
    <name>A0A7D5YUN6_9HYPO</name>
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        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RPS3C</name>
        <name evidence="10" type="ORF">G6M90_00g087880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="QLI72540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_014686841.1"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="233"/>
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    </feature>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI72540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="257" mass="28200" checksum="5793AEE627462952" modified="2021-02-10" version="1">MAHPGAQISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATQTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKEFIDTATRHVLLRQGVLGIKVKIMRGSDPDGKAGPSKSLPDAVTIFEPKEEQVVLQPVSQDYGAKAAAAQASQDARVAEQEAEAEPAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUQ0</accession>
    <name>A0A7D5YUQ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellobiose dehydrogenase-like cytochrome domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g074690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131010.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26241631"/>
    <dbReference type="KEGG" id="mbrn:26241631"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="602"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="3">
        <location>
            <begin position="339"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI70222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="770" mass="85103" checksum="461B106DAEF1CA90" modified="2021-02-10" version="1">MECLDGLAHLQAVLEGAYEAAAQAVFGVRWWPIVSWASFLRAVPFTATVLAACNGHNELCGKRYSEVTFVGSHNSAFVGNTPMHNQYVSVTDQLNLGVRFLQAQTHNKFGTIEMCHTYCWELDSGTLKKYLQEIADWMNRNPNEVVTLLLTNGDAIPVQRFDAVFRNTGLSQYAFHPKAVLSKGQWPTLQQLLDAKTRLVVFMDYHSDQSKVDYIINEFDYFWETAYGITDKDFPTCSVNRPSRGDPNKLMGIMNHMLNIKIGDIVFPDQVDTKTTNSVDSITKQVDRCESQGKPQPNVILLDYINIGEAQQAQLKFNALTPAIRADGANPPGQSTFISPGNSVAFAFTVPNDNDNPRSTFFSIRVPKKYTWGGVGLGSDDMKGALFLIIYQNGDGTNVTFSPRIAHGNYEPFFFRDMRWTVIPNQTGIIDDYMIFTAMCTESCRTWPGGDTTGGYIDVSSPAQPAIYAVGPEGTLKDDSPSAGLRYHHEYGVFNIDMRRTRGAADAPVLDTHTRLDGAVQVSSVTTKGDLKATLHAAFMIFSIIGLMGFGGILLLPAVGLAKWHALNQIVATMGVLGGLFLGVLASFNYQRSRSFKHHHQVLGYIIVAFILAQLGLGVQHHFKHQRTKAPTIFGQIHVWLGRLILLLAAVNGVIGFTFALKGTSAIVFGVFVCVFTVAAVLLRLRYFPIKSHKFQPVGAQQSHTWRQSSGYNAGYSSRHPPGYEPPSQQIGLQATRSSSENSPWKSGNNKDCEDDEPQLGNAQRPREFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YUX8</accession>
    <name>A0A7D5YUX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">qutE</name>
        <name evidence="7" type="ORF">G6M90_00g005200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542167.1">
        <property type="nucleotide sequence ID" value="XM_014686681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YUX8"/>
    <dbReference type="GeneID" id="26245198"/>
    <dbReference type="KEGG" id="mbrn:26245198"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="150" mass="16304" checksum="B2EAD969EB34687A" modified="2021-02-10" version="1">MPRILLLNGPNLNLLGTREPQTYGSTTLSDIIATLTTQASSLSSTIESFQSNHEGALVDRIHQARGDIDAIIINPGAFTHTSVAIRDALSGVDIPFVEVHISNVHAREEFRRHSYLSDKAVGVICGLGVYGYEAALEFVVRHVKSHASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YV60</accession>
    <name>A0A7D5YV60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyoxalase/fosfomycin resistance/dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g078930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545217.1">
        <property type="nucleotide sequence ID" value="XM_014689731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YV60"/>
    <dbReference type="GeneID" id="26241250"/>
    <dbReference type="KEGG" id="mbrn:26241250"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028936819" description="Glyoxalase/fosfomycin resistance/dioxygenase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxalase/fosfomycin resistance/dioxygenase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="235" mass="25860" checksum="025556EE488AD5FA" modified="2021-02-10" version="1">MVFKSIFVAMALVLAHPVLPVLACVKRSNDSMGNELDFQLGSDAPSDPATVGYLLNHLSLNVANLSASIAFYEQVFGMRHMFTIQVTDHYSFAYMAHSHGGRNGTGYQTAAELNRERTNSAGMIELWNLQVPRRDLPESGDAISRVGHFGMIVPGIKAAQARFDTFPDLKILKRYGDPFPTQGRIITANSLSASSLGQLDAEERKNIADSLTSFHRTFIFAEDPDGNIIEIQPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVH0</accession>
    <name>A0A7D5YVH0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g033900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986286.1">
        <property type="nucleotide sequence ID" value="XM_066130138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVH0"/>
    <dbReference type="GeneID" id="90967605"/>
    <dbReference type="KEGG" id="mbrn:90967605"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI67024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="59" mass="6686" checksum="6355F5E3B80BDDBF" modified="2021-02-10" version="1">MQQETLRLAVDESHHSSFGIPMALFWAHIQPYLVPRGTKERNPIISTANQTLGLTPDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVI1</accession>
    <name>A0A7D5YVI1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g075040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987154.1">
        <property type="nucleotide sequence ID" value="XM_066131036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVI1"/>
    <dbReference type="GeneID" id="90967975"/>
    <dbReference type="KEGG" id="mbrn:90967975"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI71042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="84" mass="9619" checksum="47A1DB605D3A2B87" modified="2021-02-10" version="1">MSETYTIADVQKHKTEADGMWLIVENNVYDITKFLPEHPGGDRILKRFAGKNATKAFWKYHSESVLKKYGDKYKIGTVAEAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVT1</accession>
    <name>A0A7D5YVT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="2 7">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alg13</name>
        <name evidence="7" type="synonym">ALG13</name>
        <name evidence="9" type="ORF">G6M90_00g075670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 7">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 7">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="2 7"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545532.1">
        <property type="nucleotide sequence ID" value="XM_014690046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVT1"/>
    <dbReference type="GeneID" id="26241565"/>
    <dbReference type="KEGG" id="mbrn:26241565"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="211" mass="23753" checksum="6CB57B7790A82C3C" modified="2021-02-10" version="1">MTSNSGALERYCLVTVGATVGFEELTKEVLQSAFWQFLREQGFTALHVQCGPDIPWASARFSDQKEKLPKGFDVDVFDVKPNLMKDEMVLCQARPGQRAQGLVISHAGTGTILDAWKMGLPLIVVPNTRLLNDHQTEMAKHLARQGYATMSSADRLDLQEAIHKAVLLWEENKTTRWPAHNVRGKEKETLGLWDIRPGEVKKEEISQMSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWE8</accession>
    <name>A0A7D5YWE8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g086050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541164.1">
        <property type="nucleotide sequence ID" value="XM_014685678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWE8"/>
    <dbReference type="GeneID" id="26246153"/>
    <dbReference type="KEGG" id="mbrn:26246153"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="484" mass="53131" checksum="BB5B8867A63DBDDC" modified="2021-02-10" version="1">MLRTLRVRPHLVRLFQAQALQQRFIKRHGTQSTPGSSNVGNVMRYVSTAIVLAAIGAWWSLATTDPAPPLESRPGQHLLVESDPSKAEVTRILSQDAYSFIVRNVAGVGRYDGAQLASNSPCEDRFTHGLVFPWHNGSPWVALALFDGHAGWQTAEFLEKNLLPSVQQSLGLMKPPSNGQVTPERTIHDAIMKAFVDLDNSIIKKAEDASESDQSLQEKVRRFAPAFAGSCALLSLYDPMTSGLHVACTGDSRAVLGQQSPDGKWEAVPLSTDQTGRNEAEVARLNAEHPGEEGLTQDGRVLGLAVSRAFGDGRWKWPSETMESFSRRFCGPGVLPPKYSIRTPPYMTAEPVVTTTTIKSDRPSFLILATDGMWDRLSNQQAVDLVVAWLDSRSQGAGTEEPTSYPPFDFGSFREGVSPGFVKERTIVQDDNAAVHLMRNSLGGNHFEMVAGRLALTPPYSRNRRDDITIQVVFFNSDTAQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YWV0</accession>
    <name>A0A7D5YWV0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ATG3</name>
        <name evidence="12" type="ORF">G6M90_00g089270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541590.2">
        <property type="nucleotide sequence ID" value="XM_014686104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YWV0"/>
    <dbReference type="GeneID" id="26245453"/>
    <dbReference type="KEGG" id="mbrn:26245453"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="348" mass="38901" checksum="08C34740C890E177" modified="2021-02-10" version="1">MNYIRSTVNTLRDRYTPVSHNSTFRQTGQVTPEEFIAAGDYLVYKFPTWSWGDADSEDRRVSYLPAGKQYLVTRNVPCHRRLNDDFAGDAGHEEAIVNDGDDFKGAGGAADDDGWLRTGGLASSQPLKARDVRAVDDAGNLADTTDLDDDIPDMEDEDDDDAIIRDTSAESKSAGRRTYTLYIMYSPYYRTPRLYLSGYLPNGQPLPPQSMMDDIVGDYKDKTVTLEDFPFFANNIKMASVHPCKHASVMKTLLDRADAALRIRRDKLRSGKAVGSDPGMEGLVDEVAKLDVKSAQEAADKDEWEEVEGVDADEQEVAIRVDQYLVVFLKVRTHHILPIPWPRRGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YXJ0</accession>
    <name>A0A7D5YXJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g028170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066130006.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="90967552"/>
    <dbReference type="KEGG" id="mbrn:90967552"/>
    <dbReference type="OrthoDB" id="5415741at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="80" mass="9155" checksum="ACFC47989084EBB2" modified="2021-02-10" version="1">MPEINVATKAAMLALYAECDYSALRLTQLFDVSQTSVRRIIKEARERGFNPTRRPLRIEDKYLEPKPRTGGTKKNPATYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY20</accession>
    <name>A0A7D5YY20_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g012120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY20"/>
    <dbReference type="GeneID" id="26238754"/>
    <dbReference type="KEGG" id="mbrn:26238754"/>
    <dbReference type="OrthoDB" id="5398685at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="74" mass="7662" checksum="5190D43F13FE0399" modified="2021-02-10" version="1">MSPAEEQTPSKGSDREPADLAQAYRELVKGEQAATALEANLTNLESKLDAMLAALEEKASGAEGKAQGDGESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY88</accession>
    <name>A0A7D5YY88_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g014280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549094.1">
        <property type="nucleotide sequence ID" value="XM_014693608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY88"/>
    <dbReference type="GeneID" id="26238538"/>
    <dbReference type="KEGG" id="mbrn:26238538"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI63746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="432" mass="48475" checksum="E9EF0C46F71B5833" modified="2021-02-10" version="1">MADFLKNVFGGGKANEPAVKPKADPDFAEFAGAPDPVAEPVPAATIGGPGAAATSRPYTKWYNVHERHSLSEFKAEGVILAISALIFLFHMIGARANRSKARSWIRANASILRKEFALVGFGAVPTMDNEHIKPDSLLKEKSLFEFATYASGRQNTAFVDVKLTLTKKFNPIMNLAETAASFFSDVFTAPGDVMEAFLYPFDGKESLTIPSLPGSEEARAKDAKSNYDGFVWALVNKESMKRLREDRYDVTLTATKESPKLPNWLTIMSESAEVTDTLLTQDLIDAVVAAGDKFEYLIVSDQPVDKPVKLDDAAPRKRIFLKYRLPSDNKYDNLLPIFSHFLRLPDFLVQNGRFRPEVLKKVRATREAMISHIKKAAEEEKSEERQFEKEKAKKAKRDAELKGLDAKAQKKYLEKEKEKELRRSQKKMTMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YY98</accession>
    <name>A0A7D5YY98_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">apc11</name>
        <name evidence="15" type="ORF">G6M90_00g057240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986726.1">
        <property type="nucleotide sequence ID" value="XM_066130634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YY98"/>
    <dbReference type="GeneID" id="90967809"/>
    <dbReference type="KEGG" id="mbrn:90967809"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="95" mass="10873" checksum="9D8744B289B1DC9F" modified="2021-02-10" version="1">MRVTIKEWNAVATWRWDIPEDDVCGICQVHFDGTCPTCKYPGDDCSLLSGKCGHNFHMHCIMEWIKQESARGQCPMCRQTFEWTDQANDSASQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYT6</accession>
    <name>A0A7D5YYT6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g108000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014688558.2"/>
    </dbReference>
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    <dbReference type="GeneID" id="26243431"/>
    <dbReference type="KEGG" id="mbrn:26243431"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7928"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="790"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="845"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="3">
        <location>
            <begin position="46"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="521"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI74022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="902" mass="101019" checksum="9B2E9F4BE1FD01C2" modified="2021-02-10" version="1">MSAHGIEPSMARNRSFCTISASSIDSSPQRSGQDSPYNANHHDDFRFRTMVTYLHNRAVASGWIPPESVRSPEDCSGVLLRRSRGNYIASQTLNPILLGAAIRLNLHVAITMRPQMLQGILASLLPGQSDLKFKDGSQIQVLDSLALAQPATVKKFQYACVFRQERLILVWHDDLVHIVPQATHIEEKLLAWVWGEGRLPVNILHMPSRAPSTLYDSGISSPIGTATPAAGITTPGLLMQLSSSEDVSEKNAAIERPESVARPVARASAFFIGCAMCLSLCLLCGVYVGKLVTECILANDWIKMALIFPVPLLMCVSLFFFQVIFTNIFQMIGPIGGINTNSRYFSAHKPCLRRAYADGFVPPKVTIQMPVYKEGMDSVIIPTVRSLQAAMSYYESHGGSANIFINDDGLRAGLTDDEIRCRKDFYADNRIGWVARPKHNGDEDFVRKGKFKKASNMNFALNISQKVEAYMQDLADARLANKETDLITDAEEEEMYQSALARVLEENPLAWADGDIRVGELILIVDSDTRVPEDCLLYGAAEMFLSPEAAIVQHSTGVMQVTHDYFENGITYFTNLIYSSIRFSIGSGEVAPFVGHNAFLRWQAVQDVGVPEDDGYVPYWSESHVSEDFDIALRLQMKGNIIRVADYHDNEFKEGVSLTIYDEIARWQKYAYGVNEMIFHPMHRWIYKGPFTPLFYTYITSNIMVSSKISILAYMCSYYALGSAMFLTALNYFIVGWFRDDLASSYLTSWNVLLSLVVVFNAAGPIALAIVRYRTGEKALLEGLVENFKWMPMMTVFFGGISFHISNAILAHLFHVDMQWGATSKEKEDSNFFQEMPRIFRTFKYMYLIIVLLVGAMVYLGAFAPPDWAITDFSVIVPLAINLGFHALVPLVLNPSLMIFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYX7</accession>
    <name>A0A7D5YYX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hmgA_0</name>
        <name evidence="15" type="ORF">G6M90_00g040680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547416.1">
        <property type="nucleotide sequence ID" value="XM_014691930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYX7"/>
    <dbReference type="GeneID" id="26239979"/>
    <dbReference type="KEGG" id="mbrn:26239979"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="297"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI67945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="468" mass="51307" checksum="000205AD1EEB3106" modified="2021-02-10" version="1">MPITEFETKEKYRYQSGFNCHFESEAIKGALPIGHNSPQAPPFGLYTEKLSGTAFTAPRHENKQTWLYRILPSCAHPPYQPSPEGTAPELVVRESSKMHYIPNQLRWDPFSHDESKDHDFVSGLKLVAGAGDPTQKQGLGMYVYAAGKDMDEKSAFYSADGDLLIVPQEGDLDIRTELGWLLVRQMEIAVIPRGVKYNVRLASGPARGYALELYEGHFSLPELGPIGSNGLANARDFVAPVASFSEDFGATAHEGPNKYLVTVKFNNTLFQTTQAHTPFDVVAWQGNYYPYKYDLGRFNAIGTISFDHPDPSIFTVLSALTPVAGTAVADFVIFPPRWLVGEDTFRPPWYHRNTMSEFMGLIRGAYDAKKAGAGGFVPGGASLHNVMSGHGPDADSHEGARAAKLQPVKVGTGSCAFMFESCLMVGVTEWGLRTCKKVQEGYSEESWGGVVTHFKLPEGAVANSHLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZ87</accession>
    <name>A0A7D5YZ87_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g098080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546535.1">
        <property type="nucleotide sequence ID" value="XM_014691049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZ87"/>
    <dbReference type="GeneID" id="26240958"/>
    <dbReference type="KEGG" id="mbrn:26240958"/>
    <dbReference type="OrthoDB" id="5244801at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="548" mass="60228" checksum="6B2F1F0919F9D4EA" modified="2021-02-10" version="1">MKPDLATAIFQISPTNPPKIMANGLDRLERLFAYKRKASPTSSGRASPAVLAIEQQFPSPSFIRPKTSRMAARDEGRLRQAAGRSPSVPDIMTSPRTVHRQAYNSVTTDCNDPPKQRLCRSPSFTQGNTEQLVTGLREFQFPKKYSLNNEPSPTSPTLSTPKFTEAPQLPSPRSRSPLEISIPPPNRLITPPTSHHGSQSASPTSQGPQIPLPARPPTPGQSPDLGPVADIKLRNVKSADALDRSLFKDIEAQLGEPFDRFSLNRSYSQSSLAHSTHSFCSSTLREPDFNEFLNLSDDDIAESNPDSPSLEPLEEGSQSAVPPMNLSMSPQQAPCALLTLTPPRASRPAAAAAFEAARIARRYDFDLVYVVNLWPDTSKQTSGNCLNGSPKPMIGRLLAAHGLHHVPSPLQISTHVHTQVLKSDGWIEYRNQHARPHDLARGFTCAFYTGQYARSTSSRSASPVSGIRLSERIDRGIVFAAYRKPRASEDKLGRNFNEDELGELHRDAEVLVEMVIDIHVANRSRQPPTRTSHTDETGPIPLQQVDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZQ9</accession>
    <name>A0A7D5YZQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g061470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542722.1">
        <property type="nucleotide sequence ID" value="XM_014687236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZQ9"/>
    <dbReference type="GeneID" id="26244671"/>
    <dbReference type="KEGG" id="mbrn:26244671"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39893" checksum="577F366FB6A6E60C" modified="2021-02-10" version="1">MTLPTFPSLFHGIHKADIGDSSRRLPGHPQTTLDRSAILQFLQNDFRTPQLDAFSKWLWLVSTQDSSHVFSLTHQVAVGREITVTENPELHLVWHDHRVFLKPIPPFLLSYAFWSAVLEPEPSAGTNKDAVYKSILGFMRTYQHLVQHPSDFALAEKHGLLPIDCNSIYKRADGESVAAELAFGEENSNITYTSFINFIQAFGPLAILDADVSPRYQYGQLRLGPLNFWGKFVLRKFVFFKVYGNYDAYFSRFYGPLLFTFGVLSIFISSIQLGYSSQQGLYGTTKNSWRPLYKVGEGFCVAVMLVVCLIGVCLIVVFVFMTAREITLALAALRRKKRKSNSHAAWQGQLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z072</accession>
    <name>A0A7D5Z072_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g029510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985990.1">
        <property type="nucleotide sequence ID" value="XM_066130033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z072"/>
    <dbReference type="GeneID" id="26245855"/>
    <dbReference type="KEGG" id="mbrn:26245855"/>
    <dbReference type="OrthoDB" id="4958856at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="87819" checksum="31090E2572C0F0AC" modified="2021-02-10" version="1">MRGQDDRDGVAPPAYAAEQAEAQPPVDVDTTAAFAHLSLETDIAQRRLTVDTCLAHLKLLHAIHNLKEEVGYTDGLFGLYDSRAGHDADGFDLDAIHAGKGIKMEDAEKVKLALSKIREKRWALFVARAVDRYETWWRVIQGQNHLTQDMMAEPASDLYANFPILCKDPRGLGPDMLPPLDVLMVFHSHMLNPRAFLEDSIRSSMKGLWQDGMPWPLINEAIDTNFDYSVSDACPTRWTQATGRCWANTGEPMVKIINCPYCQVPNHIPWTTCGDQESTNRQDGLSGLVGSGYGDGKLSHQCVACHGNICKEALSVRKFVQDSALLLAKSVPMPGTILDPQNGMPELVPSGHQENVYPRTFPNRMIQLDLRIQIQDIFKSHRNPTMETVKSLVEGVLRDSSRLCRINSMPPRWSSRYKIPPKSKNCVRKMMSRYWENFSPFALDLCGAVMRQGVFVDKMVKLDWLHSPSARETMARLIDKYVKFMELMRRYPKQIAVPTLDVDLAWHTHQLIPPSYYADTTRATFKFIDHDDKIEEVKLNQAFEWTSKTYQVLFHELYSECTCWYCEAIRASHTSSLNSFLGTSKGDKYAQDFYQSGRAGRCPPDNSAHISAHNAVRSADASRGPVSAYLRSRQEESLERNYQKAVKRAEKKGRTLPPRNDYYDHWGYSYFMYSPAVYPLYLAPGMYYGWDPCYVHTGAGAWGGCAAGSCGGGGVAAGAAAGLEREVVAAQEAAEEDRDREAAEVAEEEEDVEEEEEAAAADVEEEVPNCIGLCSLQRLSSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0I5</accession>
    <name>A0A7D5Z0I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pim1_0</name>
        <name evidence="11" type="synonym">PIM1</name>
        <name evidence="17" type="ORF">G6M90_00g022130</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548340.1">
        <property type="nucleotide sequence ID" value="XM_014692854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0I5"/>
    <dbReference type="GeneID" id="26237784"/>
    <dbReference type="KEGG" id="mbrn:26237784"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000006">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="180"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="905"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="824"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1097"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="824"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1097"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="997"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1040"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="604"/>
            <end position="611"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QLI65827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1124" mass="123336" checksum="6306EC2A4A20E51D" modified="2021-02-10" version="1">MIPRSRLCGRLILERSAAHASRTSTSSISPRWALSPACHSRHICRSTLPGIRPGLVGAAFSTTARLRKKDDKGKKDDFFDSSAETLTEPLSEEEVKANLGNKKKDAERAAADAKSDSSTAKADAGSKSQDGKSSGAAGSSAEGGSGSGGDSSGGDGGKKGRKSSEKALQKPVVPEVYPQVLAIPIARRPLFPGFYKAITIKDPNVASAITESIKRGQPYVGAFLFKNENEDEDIIRNVEDVHDVGVFAQITSAFPIHGQEGALTAILYPHRRIKLSSLVPPSAAEQIDGKQEPDTPEVIPQQNSGEEDAQQEKKGDVVASFEEGAVEKKPDQVAEKYEPTSWLKRWPVSLVNVDNLADEPYDPKSPVIRAVTNEIVNVFKEVATMNNLFRDQISTFSMSQSTGNVTSEPGKLADFAAAVSSGEQNELQDVLSCMNVEERMQKALIVLKKELMNAQLQSKITKDVESKISKRQREYWLMEQMKGIRRELGLESDGKDKLVEKFKEKASKLAMPDPVRKVFDEEINKLAHLETAASEFNVTRNYLDWLTQIPWGRRSPENFGIPNAKKVLDEDHYGLQDVKDRILEFIAVGKLRGTVEGKILCFVGPPGVGKTSIGKSIARALNREYYRFSVGGLTDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANMTDTIPRPLLDRMELITLSGYVADEKKAIANTYLAPAAKDAAGLKDANVNLTDEAVEELIKSYCRESGVRNLKKQIEKVYRKSALKIVQELGEDVLSEEKALTDEGKAALEESQKKKTEEEAAANDEAKSEEARAATEATEAKTAEKPRKALRVPDSVDVQIGKDNLVDYIGPPVFTSDRLYDVSPAGVSMGLAWTQMGGAAMYIESILQAPLRASTRPYLEITGNLKSVMKESTTIAYSFAKAFMARQFPENNFFDKAKMHLHVPDGAVPKDGPSAGITMATSLLSLALDTPVDPTVAMTGELTLTGKVLRIGGLREKTVAARRAGCKTIIFPKDNMSDWLELPQNIKEGIEGHAVGWYTEVFDLVFQDLDREQANRSKVQDVKKEVERSEEDEEKQAERQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0T2</accession>
    <name>A0A7D5Z0T2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Inhibitor of growth protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dng1</name>
        <name evidence="12" type="ORF">G6M90_00g015600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986100.1">
        <property type="nucleotide sequence ID" value="XM_066129775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0T2"/>
    <dbReference type="GeneID" id="26238413"/>
    <dbReference type="KEGG" id="mbrn:26238413"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="760"/>
            <end position="812"/>
        </location>
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        </location>
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        </source>
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            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="828" mass="89626" checksum="B887AD1263429EFC" modified="2021-02-10" version="1">MAAAGTDQAVARDVEGAASPKDTTSANRTAAGQAGQSGQAMENANKALEPRADPDAQTTVTDFLDFTEYLPSDVIRSLTLIGKLDETYTDASVKVDELTTTWGQLPSLAAEDRPSPVKLRADISEKLSQAVSSRVFAHDEAVRMSENVNRHYNKAKVLLAKLQGMMDNYPAEEPKSPVASRSPHAVRAKPAIGEDGQKIRHHRIPKVTVPGEVLAPYEIEYDTASDDSDISTDEDSDIYGTGRRTPAPPRIKIISNKPNKPNSRLARPVTYSSAAMTAAAAANAAALLNPPPENAVVGSVDAPWLQLTNYELAKLRKRMKKNATWTPSETMVARELKALGRGPDEYRDAKQKAEDEGKEFNPQVPKLVVDDESGAQHLPAGAISADLIGIEEVPTSNRGMKLNEAKKLKREALAKLAAEEAEESARKMTHAAKLFMGNEKNKSENSKDSKETKGGNQPLEKSRAASSRPNGKRKREGESGTEPSESAETTPPRPQPKRSKMETPVPPPQHPGMNQNNAPPADSSNNHIHINNNTSSNKINNNSASSSLQPMTPGQSETPVPIPVPPQSSSRSALSPTPNSTSSNNVTTTTIPVKPPAETPVPLPRTDRRKSMTPVAPPSREPAKRETRGEAAKRTQHASPPDVFSLRPPSRGQTPIATRPGSRGKAASQEPPSLAADRPRRSSTARNTPIPEFKQPAKRTKRPAPGVVSTTNSGGSSAVGKRKAPPKKKARTTKREKGQVLETEMEEVDDEGNPIDPNEPRYCMCNRVSFGTMIQCDNIDNCKQEWFHLECVGMADIPARTTKWYCPDCRKLLNIGEKGEVSARGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1F0</accession>
    <name>A0A7D5Z1F0_9HYPO</name>
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        <submittedName>
            <fullName evidence="4">ML-236A carboxylate methylbutanoyltransferase mlcH</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">mlcH_0</name>
        <name evidence="4" type="ORF">G6M90_00g009090</name>
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    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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            <begin position="14"/>
            <end position="378"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI63989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="44844" checksum="644C13EC59314B67" modified="2021-02-10" version="1">MNRLDDILRRYTVQGEDTKDRLLGAAFVVTDKEGTIYTGSSGRLDLDPKSPLFTERSFTWVASLTKLATTISILQLVERGQLDLDADLRHLIPELRDASILHEFDENDNPVIEANAKPITMRQLLTHTSGFSYEFSDPVLLQWSRTQPNRNVSRLQWSKLEVTTPLRFAPGQSWGYGVGLDWAGQVLEALTGKSLGQYMQENILDPVGLNDTGFWPERIPHTAPRTAQNVQRTKDGKLAAALWPTPEKHEIESGGGGWFTTASDYALFLRAFLAGRLVSEETMREMVKPQLNEAQAEFLRTIAFHPMVHNTFAPEFKPGTNIDHGLGGMLNVEDVPGKRKAGSIAWSGILNSRWWVDPKTGIAGVLIVNVRPNGDPIVAKLYDELELALYGQLLGQGAVQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z218</accession>
    <name>A0A7D5Z218_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">G6M90_00g001930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014687401.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26244260"/>
    <dbReference type="KEGG" id="mbrn:26244260"/>
    <dbReference type="OrthoDB" id="4937506at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI64449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="81" mass="8481" checksum="7A5936846DB704F6" modified="2021-02-10" version="1">MKRQTTAAHSTTCAAKRVTFALSTFACSKDPKHGTYTGLVETCDGHPVVPGCPVCAEDYMAQRAAAYRSTNGAGRGAGQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2L4</accession>
    <name>A0A7D5Z2L4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">sec18</name>
        <name evidence="15" type="ORF">G6M90_00g071740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545885.1">
        <property type="nucleotide sequence ID" value="XM_014690399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2L4"/>
    <dbReference type="GeneID" id="26241918"/>
    <dbReference type="KEGG" id="mbrn:26241918"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="345"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="627"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI70765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="840" mass="91162" checksum="230F7DC5866F2EBE" modified="2021-02-10" version="1">MSGVPPGGPGRLPYAPSLPGSNPRMPPNQGRPPPGSSYGADPSQGYGTPQGYGDPRVSQGSGPQSPAMPRYSEKGPSGPSGARRVTLRVEKVADRTLQSRLIYGNICAVAPEDFPPSRDGTDLYILVRGGQPEGEFVVTAKPVPGFPQGGISLSDPQRSWCNITIRDIFTGELYDPFAQGGRAYLGSVDLEVGFASPNKRTDAPYDEDHLAAQFSDTFANQVLAPGQRILMDVRNIPLLIVVKTVGLVDLAMSSDDPSKQVFREGHARGILTSQTRVLFHRDGRSDFHMKPSMSKPNSNAILAPDFKFEDMGIGGLGDEFSTIFRRAFASRVFPPGLVAKMGIPHVKGMLLYGPPGTGKTLIARQIGKMLNARPPKVINGPEVLNKYVGQSEENIRKLFADAEKEYKEKAEESSLHIIIFDELDAVCKQRGSGAGGGTGVGDSVVNQLLSKLDGVDQLNNILLIGMTNRKDMIDDALMRPGRLEVHIEISLPDEEGRFDIFNIHTAKMRENNILDSDVDLKELASMTKNYSGAEINGVVKAAASFAFSRHTEVGQMAAVKQDVASMQVNRADFMLALTEVKPAYGVSEAELEDAVGLGIIRFSRYIGSTIDEMMRVVGMIKNDPNKFSTSVLFHGPKGAGKTALAAHIAMQSDFPFVKLVTPADLVGYRDDFAKKDYVHKAFADAYKSPASILILDDFERLIGWNPIGPRFSNVMLEALTTLIVSKPPRNHRLLVFVTTSKAAVLKMLEIDTDFAKRVAVPAVADAEELAAVLHESRVFNSNDIDQVVNLVRQRTGSDKVGIGIKTIQDLIFEAKAGESSSHVLETFSELLLDNIQGLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2T6</accession>
    <name>A0A7D5Z2T6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g029800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541192.2">
        <property type="nucleotide sequence ID" value="XM_014685706.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2T6"/>
    <dbReference type="GeneID" id="26245827"/>
    <dbReference type="KEGG" id="mbrn:26245827"/>
    <dbReference type="OrthoDB" id="4932158at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI64929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="645" mass="72348" checksum="07B432970245769D" modified="2021-02-10" version="1">MTNLAKATDHSPRKQNYSPTTSQPECISFSAPHLRDLVHTAPSSPFDLPKDVVQEYERVSAKNSDDLTFKHRVCIVGAGIAGLFIAMILDSLKISGLEYDILEASDRTGGRLYTHYFSDVPHDYYDVGAMRFPDIDIMKSSFKLLKQLNLPLIPYYFNQESGSVKCPTMYNDITLIDGEPRGSDPFRVGEANGGSVPDKNVDDVNKLLDSAYEPFRKAMAADFEEGFKLLMQYDSYTTREFLKNPPPVKNGVMPFKYLDFFSIQWLETNNTASGLFDQAFSESVMDSFDFAGPREDTIKWYCIDGGSSLLTRAMEKTIKQPVQHGKRVRKYNQNPNTNEITVSVAGEPEGSRQDYTTVFNTTSLPCLQRMDLTGLDLHPSQKCAIRSLDYDDSAKVAMKFSYPWWITKCGITSGGEASTDTPLRTCVYPSYNIRDPQDQSATLICSYTWAQDATRIGNLIACHDDELRDLILDNLARVHLKNFQQQGPISYHGLTTLDEVRQIIGDAYISHHAWSWSHDPFTSGAFALFGPGKFSNLYPYLTRPAADSRFHICGEASSAHHGWIGGSLDSALASVHKFLKRFDMWEKQLELRELWDMPLGLEDGVDGTLHLQVALGMIPTSELVGRNTVRPVHNKDEATRGCIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3B3</accession>
    <name>A0A7D5Z3B3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g027810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541376.2">
        <property type="nucleotide sequence ID" value="XM_014685890.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3B3"/>
    <dbReference type="GeneID" id="26246011"/>
    <dbReference type="KEGG" id="mbrn:26246011"/>
    <dbReference type="OrthoDB" id="4935345at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="215" mass="23829" checksum="DC1005CA76B139D2" modified="2021-02-10" version="1">MPRRQRSKVNKRPEIGTLNCSWGMFSKANALFRQYDVDVVVIARRPDGGIGGYQSRPGLARDFLQINEQDLLGPHEVDPYMSKPSKGVAVLRAMSSSRSSSCLDSTENRSSRASSSCVDSIGTETSPGIMEEAEPGVALLNIVRTPHCEEGEGFMEEPLHPWAEVHSIPNAQRCASPETICPIRITKPAKEDIRQPTPLSRIKREEILALIKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3J1</accession>
    <name>A0A7D5Z3J1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">G6M90_00g015460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548981.1">
        <property type="nucleotide sequence ID" value="XM_014693495.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26238425"/>
    <dbReference type="KEGG" id="mbrn:26238425"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140674">
        <property type="term" value="F:ATP-dependent histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="622"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1336"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1490"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="326"/>
            <end position="335"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
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        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1420"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1493"/>
            <end position="1510"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1522"/>
            <end position="1532"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1627" mass="178142" checksum="24323976F1039286" modified="2021-02-10" version="1">MVSKRKRVLEDFDPNKSDSEDENFDPSEARAPRNPKKVRPSRGPRPAGGRKRSHRYRGSDIDEDDEILSDSLGEDSFGEDESEDQDAPVNAAGRRTRKAARTHHSYRESSADEEAEDVVNDSEDAGQDAQELDEPSARRLVKLKVPKGPSAGATRRATRASTADVDDFVELSNSGRHAVASRNSRSRSPETYSRTRRSSRSMKGLHAAPETIDEATQESSNRAADDADEPDELSHDYKPVEKKEDEDEDMADTTVVIADDVAEPVKEAEAVPETAAGAGAGAGAGAGDGAGTGAGAGADDNDDDEDDDVPITRRTRSSRAAADASNEDKAEETHETSTNSRRLRRGRSKKSTQEPSSDFEPGDDSEEEAMSETKGEDIESPTPRGRKDRRSARNSRRGADSGDEELDVDLDELNEEARELRQSSRPRRRPRDESPPIVYQESRRARTRVNYYMPPLTAANIEEEEVADQAPTPARRRRGGASIGWERNLNTTFGPFGGGGGGGSLLNGPWGTGAAGGVDSDSSDDEMVHRSSVGGNIGMTPTAGAPAGGLLPGGLGLNPEATPNVGKIKDRKALADADPLGVDMNVDFSKVGGLQGHIDQLKEMVQLPLLYPELFAKFHVTPPRGVLFHGPPGTGKTLLARALANSVGSGGRKISFYMRKGADALSKWVGEAEKQLRLLFEEARKTQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDGRGQVIVIGATNRPDNIDPALRRPGRFDREFYFPLPDIEARRSILSIHTKDWGLSDPFMASLAEKTKGYGGADLRALCTEAALNSIQRTYPQIYSSTEKLVVDPNKINIHASDFMLSIKKLIPSSERSATSGAKPLPRAVEPLLRAQFSEAKRLLDELLPRKKKITALEEAMYEQYNDEDHGFAREAMQQEFERSRVFRPRFLIYGPHGMGQAYISSAILHHFEGVHVQNFDLPALLADGRSMEQVIVGLFTEVRRHKPSVIYIPNVDAFYTTLSGTVAYITFKTMLRSIPPTDPVLLLATAECAKYELPSQLIQDLFGFSRRNRMEIPRPERDNRMEYFKATLEYIKKKPAEFPDPENRKKRVLEELPVAAPIAAKPPTKEEVKALKRKDHQWLNALKIQLQPIMDQINRKYKKFRQPVIPQSHIDYLFAESDPNYVRPDLAGGTIRPYEIVKDKYGNDVLRDTATGKCYYNLETTTIEERLSNGFYARPQDFLFDIKALAKDARNIGDKERTLKANELLSNVEVDIASIEAGNASVDWEGLHRRQVQRAAEAAEKERKRKTMQSILERVQSDLGGGNDSDSQGPLTLGETVPGSRTTARFQLRSPLSNGHEEAAGQDQSNLSNGTEGASKEGDVRMSGVDDDTQHATQASVMGPPAKSENDSTKHTGMTQISQRSAVTALPPGVSPSAVVNDASTTKTSDPSTHRSSNFSTQLTNGNHGAQQSSGDGDQDVELPDTLVVPSQATPSDEVWPHSQAHGLARGQVAPGTTNMSGSQVSTPSQARHSGDQAGDGLIQPSQEPQSQEPHGLRYSGSSASQPPAVEGAIENLLHLLTDGTSGCTIEQLEQINRELMDEIWKSRHEWNRHAVVVHLGGVFNDVISDIEQIQAVGSSSQRDSHLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4Q9</accession>
    <name>A0A7D5Z4Q9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">CLP1</name>
        <name evidence="9" type="ORF">G6M90_00g046200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986233.1">
        <property type="nucleotide sequence ID" value="XM_066130408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4Q9"/>
    <dbReference type="GeneID" id="26242089"/>
    <dbReference type="KEGG" id="mbrn:26242089"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="8">
        <location>
            <begin position="131"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="44135" checksum="7D51628750D254BB" modified="2021-02-10" version="1">MSIPGLGQIPVQTVHSSTRIIVLKPSWEWRFEVPAGRKITVKALSGTAEKDGVELALRNAYSFSAIKSKILTWHGCELEVDGRTDDEFVAEYASPAANPANAHVNLHARLNEMRTAAVYERREGPRVLIAGPPTTGKTTLVRTLASYATRQGFEPIVVNADPKEGMLSLPGTLSASVFATAMDPEAVDGWGTTPTSGPSTVPVKLPLVYYYGRNLPDDDPEFYRELTSKIAGTVSGRLSEDEAVRSSGVIVDSMGVSEKSKIGEDLLAHIVDELSINIIVVLGSNRMTAELSKRFSTERTSLGEPIQIVGLDRSEGVVERDEGFLEYSREQAIKEYFFGDARRALSPQIQQTDFDALVIYKASDYSAYEKATLSRDEPSSVMQHWTLAVMHASPKDPPEVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4W2</accession>
    <name>A0A7D5Z4W2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g045390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986176.1">
        <property type="nucleotide sequence ID" value="XM_066130375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4W2"/>
    <dbReference type="GeneID" id="90967698"/>
    <dbReference type="KEGG" id="mbrn:90967698"/>
    <dbReference type="OrthoDB" id="5212373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI66529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="316" mass="34953" checksum="23B9E2E7B1CAFC7D" modified="2021-02-10" version="1">MGEFAAPGAYEVLTTSMQRDRLFNVDLDSGLGRKPTPVPAHLSRVLYVPRHSMLNLSLFDAGLQYRQAVDYSPVGGEQVTGKALMGSRLFKTRINTMACPVGHGDAQAAYVVALDIEKIRDGGDISATVHKGGQADPTPRVNIILPMLTDVFSLLSVTTRQHSGMINISTTYPLPRLRSMVGVLHFPYSRFSIPNAASVYEWQIHPLDHGTLRYTLVELDGETCQVQTDSGPQDSSIKAIYHHIGYHGSLFLPHSEGVLLLPEVVNERDGWLELVIVSSLIGLLWRIRGMEIKDAEPQAASVKNRPSLMKRIFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z559</accession>
    <name>A0A7D5Z559_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conidial pigment biosynthesis dehydratase EthD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">EthD_1</name>
        <name evidence="3" type="ORF">G6M90_00g113830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539688.1">
        <property type="nucleotide sequence ID" value="XM_014684202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z559"/>
    <dbReference type="GeneID" id="26247519"/>
    <dbReference type="KEGG" id="mbrn:26247519"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="142" mass="16538" checksum="0E5C18A8BB01D349" modified="2021-02-10" version="1">MAISDSLSPEPQQLLCLTITAYRKPGMSEAAYREYMTKTHAPLVSGLMEEYGIVRYNMTHNNSKSRPLLFQLYDPEFSKLSDYDCIVQFVFRRMEDFLRMKSDPRFLEKVAPDHQKFADTARSTMTIGYFEEFLENGKVVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z574</accession>
    <name>A0A7D5Z574_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hhp1_1</name>
        <name evidence="3" type="ORF">G6M90_00g089580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541620.1">
        <property type="nucleotide sequence ID" value="XM_014686134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z574"/>
    <dbReference type="GeneID" id="26245483"/>
    <dbReference type="KEGG" id="mbrn:26245483"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="250" mass="28985" checksum="477E4EB22080B88D" modified="2021-02-10" version="1">MPKFLWFGQECDYFALIHELLGPSLEDLLNYCDRSFSLKTILLIADQAISRIEYIHSKGLLHRDIKPDNFLLGVGKRGNILYTIDFGLAKEFRDAEHYPTLEGRVLCGLLDTPASTTIMDAVEQSWSDDLESLGYVLLYFARGSLPWQGIKAATDKEKLERVKNYKKTLSVEELCSGLPEEFSTYINYTRSLGFQDKPNYAYLRRLFRRLFTSKGFNYDNVFDWTEKRFYELRDKAEEPIMEQGSDSNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z589</accession>
    <name>A0A7D5Z589_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NUP84</name>
        <name evidence="9" type="ORF">G6M90_00g109550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543901.1">
        <property type="nucleotide sequence ID" value="XM_014688415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z589"/>
    <dbReference type="GeneID" id="26243288"/>
    <dbReference type="KEGG" id="mbrn:26243288"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="913" mass="103563" checksum="1B3CB1AB5D13F0EF" modified="2021-02-10" version="1">MDPGKRQQQQQTGVVNPGPEVEDFANALDACLMPGLSVQEKKSRVLDLPRKYHENAIRRLAQKRPKSARGGSEDMDMDVDERLSNGGKMENSDDVKQLEKEVETWDLFRRLLPLRYSDSNDESMRFSPLSAAKPAQRDYVSDYLTTDGIALERRAVLQWLQTNSASGPDIDDLARKLQQDADRGDIIAHGWLHTRSKIKLRKSMTAWPHLLDRQSPNVTASHLNADGAPLVTHLDPDASTRQRRKLEPQDEFFERAIWLGCFKHLRRGSNLKDIREWCQERTELWRAVSMSAMPLSVDDNQSPASNIDPSALALWRRMCFALARQGGSSDDERAVYGVLSGDILSVEKVAKTWDDYLFANYNALLRSQIDAHMLSQCPSDVASNMTQSFPSFDAVQFHGNQEGIEKRLVNSIESRPDMEAQAREPNKALQASFIAKELERHLFEQGQMLTRRANEFEKSRLVRRGLAAADGVIEGKYFDFSQHSGLRIVAHVFVLIALLKRFEGHRHSWMEPGFPPDKRFIQENILASYTDYLRRCKLQELIPLYCSVLDSPRSYEVLAWNVIEEPDASNRITQLKLIKRAGIDVLAFVERQATLLFDELDHDATSFAAEKLFNILGDGPATARHGRPIKPDFFGEEEDKVDIKDVHVIRSLEWLLTVSETWPQVFSIGTRVYKFFLRSCRLNAARRLMQKVSYSEVMRGMTDQDEGDVAMYDDINFWVQQLQLSGIENVRPEQVMADARNYRELEALVKALDSLETMASLVVISRDADASNREFWNGVGSTIDATKDNMQPLLHNWLLSGIEAGDNELKRLRQAYLPETILAYVSALHFAGTGLTRDHLLECMELASVIAERNSDLADTFVSAGRMTELVEAFTACSKALAIATGDSKRPVGSASKELRYMGWSRDLWSIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5P1</accession>
    <name>A0A7D5Z5P1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-galacturonate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gar1_1</name>
        <name evidence="6" type="ORF">G6M90_00g083570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543577.1">
        <property type="nucleotide sequence ID" value="XM_014688091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5P1"/>
    <dbReference type="GeneID" id="26243754"/>
    <dbReference type="KEGG" id="mbrn:26243754"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="309" mass="33905" checksum="82390133C5254829" modified="2021-02-10" version="1">MSDLKFKLNTGAEIPAVGLGTWQSKPGEVQAAVSYALQNGYKLVDGAYCYGNEGEVGQGLKEAFAAGVKREDVFVVTKVWATYNTRVAEGLEKSLQSLGLEYVDLLLIHWPVLLNPKGNDDKFPTLPDGSRDIIRDWNHVEAWKQMEQVFASGKAKAIGVCNYSKKYLEELLPHAKVVPAVNQIENHPSLPQQEIVDLCNEKGIHVMAYSPLGSTGGPMMSAAPVVKLAEKKGVNPSTILLSYHVARGSTVLPKSVTPARIKANLEIVKLDADDMKVLTDYSDDLTKKGELKRYVYPPFGINFGFPDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z5Y8</accession>
    <name>A0A7D5Z5Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeobox protein HOY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HOY1</name>
        <name evidence="9" type="ORF">G6M90_00g064480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540095.1">
        <property type="nucleotide sequence ID" value="XM_014684609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z5Y8"/>
    <dbReference type="GeneID" id="26247131"/>
    <dbReference type="KEGG" id="mbrn:26247131"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI69786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="620" mass="67688" checksum="EB0659528092327D" modified="2021-02-10" version="1">MATEVEHTVALTTASSVPDPGSFPESDVVTPTSSNKLSPSQSSSGGNGHSNSKRPPRKSTLTQQQKNQKRQRATQDQLGILEMEFNKNPTPTAGVRERIADEINMTERSVQIWFQNRRAKIKLLAKKSLETGEDIDSIPESMRAYLAMQAMETGKGLGGNYLGRTGLMPFGHNGMLLGGDQAQGKVLIHHLTCRSLSIGKWTRVGQNTMDLIIFYSPDKCTMTYYINNEQAGYKIEYPFSYIKNIWLENNEADPNKMGGIVIELNRAPHFFMDSSSTTSGFYQVGDFTEDLQATQCMIHQLGGNPKVLTNQLAKLVSLDSFMNRHNPQHFPAAVVADPHAISVSAPVSPTARPASQPNFQQPHAGMMQEHWGMNQMHSAMRPPPHGHKRQRSRSVPGPIDFAMFQNQPMPSFYIQPPGEMGPPQHNPNIYAPVPQQPSGMGHNLRIDTQAGFGLDMRQYPMSATTASPSEFPPSPAGTYLSQGPDTGPLPPTNFGTPYSNGAFLSPMVGPEHNGGTMSPMPYNGAAEPSIVEQSPPMSMMGRPGSAEVYGGGHDASCAVSEDGTSLNEMYSKHTINLPMHGQSPNNFVHPQQGDLDMDQLVQFDHVEPVSLSPESVAHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z642</accession>
    <name>A0A7D5Z642_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g053420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986891.1">
        <property type="nucleotide sequence ID" value="XM_066130562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z642"/>
    <dbReference type="GeneID" id="90967782"/>
    <dbReference type="KEGG" id="mbrn:90967782"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="56" mass="6008" checksum="B9367709A08C3FFA" modified="2021-02-10" version="1">MPESSRPGAIGSPPRSLWPADDCRAPSAIQDPVVPTKPRVKRAVCEFLDPEDPAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z699</accession>
    <name>A0A7D5Z699_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secondary metabolism regulator LAE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LAE1_8</name>
        <name evidence="2" type="ORF">G6M90_00g113430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539762.2">
        <property type="nucleotide sequence ID" value="XM_014684276.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z699"/>
    <dbReference type="GeneID" id="26247427"/>
    <dbReference type="KEGG" id="mbrn:26247427"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF14">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="373" mass="41943" checksum="36DB87694D56E227" modified="2021-02-10" version="1">MPTPRADELDAVMVDGIDKHDDAALHPLCDFEFTFESSMLLIEPDSGESEVSSFSDASLTNSVLEYPKLFGRTYHAFHAGSYVFPNDEKEQERLALQGPIMQKLMGGKLHFAPISSRDYPHFILDIATGIGDWAIEMADEFPDARIIATDLSPIQPNYVPPNVRFYVEDATEPWDFPHKFNFIHTRLTGGCWEDFEKQVAAQAFEALEPGGWFESQEVDCNISCDDGTLDPCGPIVSWISDLILAADKMGRPTLLGPVLKRAYENAGFVDVQQRVYKMPLNSWPKNRYLKQVGLLWGHNLVEGLSAFSYQLLHHGFDRSAEEIEASLVDVRRDLSNTSIHAYMPTFVVWGRKPYPHEVGAQSLHRGKVVFGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6A6</accession>
    <name>A0A7D5Z6A6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Suppressor of glycerol defect protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sgd1</name>
        <name evidence="6" type="ORF">G6M90_00g042610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547597.1">
        <property type="nucleotide sequence ID" value="XM_014692111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6A6"/>
    <dbReference type="GeneID" id="26240160"/>
    <dbReference type="KEGG" id="mbrn:26240160"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="5">
        <location>
            <begin position="636"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="861" mass="96581" checksum="067C2293DC2B1CB9" modified="2021-02-10" version="1">MPAGSITDLQQKLFKRIGVDLHQQKQPGGAAIHRHYGSSHSLTRKENRRLQRTQKKSQRHSSHPSKPVMKRKEGNSASRPRQTLSPVPRVLASQFSDVDQVDDILSDADESSDSEYSTEEVEKWEDSSGENSADTTPNTRNRGGLSKIHLEKLAQDDAEIEDFERKLGIKKGRRSLPQAFKEDGLEELIGETGEDIAGSEDDMKKRKSVYDDWLSSKRRKTESRPVSKPVSDSLSRVRSAPTRDMTESVSPEASDIDESGIDEDDATIGLDSDQNAFASYKQPQRENPYIAPTNGEAAAKYVPLARRHENTESEKHAQPRLQRQVRGLINRLTDANLIWIVQSVEELYQSNARAEVTDILTDAILSQLRKQESLPDQFFVLIGGFSAAVYKITGSSFGSHLVRNIVKEFGEYYGQAADHDSSQHALKKEPANFLTFLTQLYVFEVVSCKIVFDYMEILLDNLSELNVELLLRVCRMAGRLLRRDDPQALKHVSTVLSSAVNSVGYTNVSARTKFMIETIQDLKNNKPSAKGTDSTIVSEHVLRMKKRLGELKSQSRRLDGLAPMGIGLKDTESVDKHGKWWLVGASVPTYRDAEERARMISKEVNRGLKDAADDEDMDFVLPDYPSKAKAQGLHTGAQIAIFTAIMSGLNYEHGHRQFVGLKLKKDDQLEITRVLVQCVGSEPDYNEYYALVGGQACVNSRIRFAFQDRLWKIFRSLGESLFGEGSEEAEETTEGERLKNESRLGNIAQFYASLVANGALGISIFKAIDLPELNVWASLFVELFLLSLLRQCRRKETSEDLKVKRIFGAASELPALAANLHWFLRKKVRKSKYIGNKETKAIQRVRTKAQAAIQGSDGDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6Y6</accession>
    <name>A0A7D5Z6Y6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g039880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547339.1">
        <property type="nucleotide sequence ID" value="XM_014691853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6Y6"/>
    <dbReference type="GeneID" id="26239902"/>
    <dbReference type="KEGG" id="mbrn:26239902"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="402" mass="42421" checksum="5A1A9E155EA997C4" modified="2021-02-10" version="1">MPDLNSVPPSPHSLALSRQQSSHQMAPPLSHPMVSSPSQSSSINILPSNQNAVSHSHSRSASLSQPHGASSSASPQLIAAQPLQSQLPPLSGDSSVGPGPGPLRHPRPLTASELHMQLEKEQEAVVNRLTRELSLLRAAQNASVVSNASSTSASASAHDPITESSLLSGSGFTIPTARRHHRNSSSASQNHGLQQLASSYEARHPVPRPAQSIPLSRQSSHSRISRTNSPGPQQSALDPSSYFHSQRVPHAPSVVMSSVAATPGSGSLTDQMSPGLMPATMRYEETAFYRNELESAKKENETLKRRIRDLERMVQTRRSTDVARPRSDSVSTTASVSIAPSGGVSIAGPRDSLIPQRPERERGLTSQSVTSAAGSVAVGVPDDEVKVGESAASSGLVGQRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7B2</accession>
    <name>A0A7D5Z7B2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g062630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542618.1">
        <property type="nucleotide sequence ID" value="XM_014687132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7B2"/>
    <dbReference type="GeneID" id="26244567"/>
    <dbReference type="KEGG" id="mbrn:26244567"/>
    <dbReference type="OrthoDB" id="4927382at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="57548" checksum="3451E10E0106DA08" modified="2021-02-10" version="1">MAPGVSLDNQFFWTQPRRKHRTLVGSARSKPIVSPYVHELSMDGPTCISSCESPDGTDNNTANANGNMGTWQLDNAVRLPTVPRQQDFSVDDVARSRASSCECEMGIDGFQQQAPAIVSDPEKTDDVENLAPQLASPSSPSSTSFGSQSTPITTPDENMLSDYRNSELYPIDPALTGLVLDCGSTCYPLIDLGSAPDASDTVAPENSLLPRDGLGLALNCYASDSPSCSAASNPSWRAVGSKSDPGEIRGCLMRAANPDQRLRKRASLADIEVPHGTSDGRRAKADEHRPTLGCGPSFTGGNHQLGDNSVEPPPPKRRKVDRSSKDGNERDEESRSRPCSVDSTIRVEPHTSTPALNSSESPVADTATTDSQDNVGMAEFGEWPLHNVLLKRITLNGVATFQLQFDWNLCATHSQLGRAIPKRRNKLDGSDRPKRTTDDSATRAKFTLDEDNLIAALKEEQQLPWTEIHRIHQGHSRQFPTRSKESLQVRYCTKLKTRRGPIVQRVRHHQVQPRAQTFSYEDQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7U1</accession>
    <name>A0A7D5Z7U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cid1</name>
        <name evidence="13" type="ORF">G6M90_00g073140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545748.2">
        <property type="nucleotide sequence ID" value="XM_014690262.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7U1"/>
    <dbReference type="GeneID" id="26241781"/>
    <dbReference type="KEGG" id="mbrn:26241781"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="111"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="766"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="252"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="956" mass="107937" checksum="66FC73A96B0A95BF" modified="2021-02-10" version="1">MPDASYSSRVFRPLGIDRDTYNSYANNDIRQQGIRPEPRPRIAEANNCTISQFSGSPDFCGPQIERSQTSSWRQQSFPPQSPNYVQTHHHASHRQYFDQEDVAAQTALLDRLCHEVVRSSEIERDEIAQKETFRQRVERICQTTISDFEQNTMGSHYFPSSSVELKCFGSLSSGFATKASDMDLGLFSPFSSMQPDVAGSMIPRMLEKAFLDAGLGARLLSRTRVPIIKLCENPPEELRHALLLERLKWEHGTGDADASEDPEEYEPDSKANENAGNLTTGSHGTESAPPVEFGSPARDNGGGDERFQLKQNAQSSLRMHYALAKRVLRRAGGRDVTASNYHEFSDMEWVTLKKVCQAFVHGLCNPELRCRLESCPSLSFGTSWSATGYRSLAGICDQAEGEQICLVWENWSSKTLICDSDAQSMEAMSTWRDIQQRTDFGANPLAYNRDLHFAFERMKRLPLVQLCRLKQDVHESPAPYHSRARVIADSLVKMDMNTSDLALKEVALRYIAGINDDKIRGEMMSLSNQSQQPMDLEELGQKHKCLDLAYKLEMATDNNFYDERLTGVIKDYIKILRTPLVKVTGDQQIARFIIPVTQVTLPLLSSIRLLRDPHKLADKQSRNKYRDALEFPSGGVGVQCDINFSAHLALQNTLLLRCYSLTDSRVRPMVLFVKRWAKVRGINSGYRGTLGSYGYVLMVLHYLVNIAKPFVCPNLQQLTPPMATLSSPSSSPNVPTCQGYNVEFWRNENEIMHLASGHQLNQNTESIGQLLRGFFEYYAQNGPLSRGFGKGFCWRRDVISIRTFGGLVTKQEKGWTGAKTVYECQIPTGDAMKYCGEELLSPKTACSDSAGPKTTHPSVTNRKHGQVREVRHRYLLAIEDPFELDHNVARTVTHSGIVSIRDEFRRAWRLIKTAGCEGWSENLLEDATEATDDHQSFMRLLEDIHGPQDQWMQAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z920</accession>
    <name>A0A7D5Z920_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL29</name>
        <name evidence="6" type="ORF">G6M90_00g088460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987501.1">
        <property type="nucleotide sequence ID" value="XM_066131329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z920"/>
    <dbReference type="GeneID" id="90968093"/>
    <dbReference type="KEGG" id="mbrn:90968093"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7514" checksum="419791E3F3262BC3" modified="2021-02-10" version="1">MAKSKNSSQHNQWRKAHRNGIKKPKTSRYPSLKGTDPKFRRNHRHALHGTAKALKEAKEGKREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z970</accession>
    <name>A0A7D5Z970_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyranose 2-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">p2ox</name>
        <name evidence="9" type="ORF">G6M90_00g079800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987151.1">
        <property type="nucleotide sequence ID" value="XM_066131140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z970"/>
    <dbReference type="GeneID" id="26247289"/>
    <dbReference type="KEGG" id="mbrn:26247289"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051473">
        <property type="entry name" value="P2Ox-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784:SF1">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="256"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="513"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI71028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="645" mass="72998" checksum="EC9F979D6BFD5E41" modified="2021-02-10" version="1">MPTDQKQREEKPALPVKVDVLIVGSGPIGAVFARELVNAQLKNREDLQILMVDVGPQDSFRIGEHKKNSVAVQKDISLFTNVVKGQLQPLSVPTGDPATHYIRNGQNPAQKANENLAEAAASRVVGGMGSHWTCCTPRQHPDEQQPGFTEVYKNYDRAEHLFNTTTTAFDHSVRQHLIMHTLEKAFNDRPIKAMPLACRRNKSPDNTNYVEWTCPATILDSGVRGHREKLSDPKYSKVPPTRAWERDPITLNDKFEVWPNTQCVKLNLAEDKDKNVKVVSASLKHLLTNAVYNVTADKFVICAGAILTPGILWNSGFTTDDKKPSYYVKELGKNLTEQTMAFCQVELWKEHVENVMTQPPVVDEKPFDPKNPTRRPVKDTKTTNKPNKEDLPKVWGDFWNTTAPKYWIEREKAEKRDEQQANASWVALRTELKDKVAKHVKTFQLDPLPFPADDPDPQCYYSYVFTDTKSKTNKRWHTQIHRDAFGYGQVPADIDQRRVVDLRWFGYTEENGDNYVTFSPKYQDEFGMPQPIFHFTEDKSQRQADMRADMVTVANRLGAIISKEDVHKNMPQGSALHICGTYKAGIGDKADERSVVNQYGQMWKHPNVVLGGCGVIPKANACNPTLTAACFAIHAVKKMVEELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z973</accession>
    <name>A0A7D5Z973_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g060360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544606.1">
        <property type="nucleotide sequence ID" value="XM_014689120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z973"/>
    <dbReference type="GeneID" id="26243018"/>
    <dbReference type="KEGG" id="mbrn:26243018"/>
    <dbReference type="OrthoDB" id="4957042at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029008355" evidence="2">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="194" mass="20940" checksum="A688FBE9B7B9EEE7" modified="2021-02-10" version="1">MRFSLILASLTAAACAAPAWHQGPVMADDDNLMERRDVVRVQVVQAHTSRFTNTMITKITRYAADAASDVQGFLSESFRGSVADGSGEVMTIAYGKKASPFVVGSGIGSGRGKGKGKGLGRHSRHRHRISLLGFRNRLAVFILAFSLVLAVACSYLRRVYIASLQGPVEDPVDSALAEKALLSRSTREDETRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z976</accession>
    <name>A0A7D5Z976_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ssb1</name>
        <name evidence="14" type="ORF">G6M90_00g076110</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545490.1">
        <property type="nucleotide sequence ID" value="XM_014690004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z976"/>
    <dbReference type="GeneID" id="26241523"/>
    <dbReference type="KEGG" id="mbrn:26241523"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="10">
        <location>
            <begin position="175"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="284"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="440"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI71048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="595" mass="66169" checksum="B102280F3655780B" modified="2021-02-10" version="1">MDAASALSRGSLDVIFNDIDKAAKLFPVPVMQCLQVKPMGASATGGERYRLVMSDGDHYVQAMLATQANHVIHEGKLVRGSFARVKQYNPQNLKGKNILVILDLEVIESLGVQEKIGSPTAVETNDAKEQTIASNDFYGTKKEESKPQAMPSRPAVHDGGNIYPIEGLSPFQHKWTIKARVTMKSDIKTWHKPTGEGKLFSVNLLDESGEIKATGFNDQCDAFYDLLQEGSVYYISSPCRVNLAKKQFSNLPNDYEITFERDTRIEKAEDQTNVPQVRFNFCTIQELQNVEKDNTVDVIGVLKDVGEVSEITSKASGKPFQKRELTLVDDTGYSVRVTVWGKTANSFDANPESVVAFKGTKVSDFGGKSLSLLSSGTMTVDPDIPDAHRLKGWYDSSGRTDNFATHQNMASMGNAGGRANENKTIAQVKEENLGMDAPAYYSIKATIVFVKQENFCYPACSKEGCNKKVVETGDGWYCEKCSVSHERPDYRYIVSLNVADHTSHQWLNCFNETGEAIFGMSANQLMELKDNDDAKFMAAFEAVNCKKLNFRCRAKMDNFGDTQRVRYQIMSAAFLDFKSEGNKLAELIKQYDMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z9C5</accession>
    <name>A0A7D5Z9C5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g104290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541425.1">
        <property type="nucleotide sequence ID" value="XM_014685939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z9C5"/>
    <dbReference type="GeneID" id="26245675"/>
    <dbReference type="KEGG" id="mbrn:26245675"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="363"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI72887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="491" mass="53617" checksum="E08E974712D5E03A" modified="2021-02-10" version="1">MPRPAIRRRQAVESVPSANPITNFTRVAKTQTLPDAAAKSAVVVEIPAPSSSRKRKASSIEQDTDRRLARRTVSFPPSSDEDEKEHTSSKRPRRAGPSAAAECIRVSTPSKGKHTAKATPSKTRTAHRPSQSTIITKAIQQEKKIQTKIDVLYQKKADRAKANGDDKSLPPQLVDLIALNKAFLKTIMIQISHSGSTAPIDIRVISPNVSRTWGKRQVTVDDIRRCIAIQSHGSEDSASPFIITDYGRGRVCVELAHGVSAASIKEDVLNRQFQDNIRALCAEKATDEMTDVHVPLQSLSLSDLPQAAITTVGNGLKANPLMAKGQSLLSELRGGIAARQQEKREKQQAQKPPLLNPDGTKMSLLDRLRHKQLARANEPVPPSGPELQRRAALNRVVDVAATISMLSLSNPLSLPRQAFAMPAISDKLRDSLRVPLSAEEGVACVRLIATEVAPEWLRIVAIGGRENVVIQRHGQPVDRVIRERVQKLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAI3</accession>
    <name>A0A7D5ZAI3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">panC</name>
        <name evidence="13" type="ORF">G6M90_00g073650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545700.1">
        <property type="nucleotide sequence ID" value="XM_014690214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAI3"/>
    <dbReference type="GeneID" id="26241733"/>
    <dbReference type="KEGG" id="mbrn:26241733"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1300.10:FF:000002">
        <property type="entry name" value="Pantoate--beta-alanine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI71169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="376" mass="41124" checksum="679B925C0EA596F7" modified="2021-02-10" version="1">MQRLVAPQIGARAAHGPRRGPSPYMWSRSLRTAVETVPSSPIRVLRAVEQVRRWRRPHTVNYRSVGLVPTMGALHEGHLALIRAAAKENHHVVVSIYVNPAQFGVQEDLSSYPVTWETDTAALAKLDRELADDGANLGRISAIFAPTTPEMYPSGFPGQAVDSKGSFVTITPVAEVLEGASRPTFFRGVATVCMKLFNIVQPERVYFGQKDVQQTVVIRRMVKDLMVPTEVVVCPTERETDGLAMASRNVYLGTRRRDVAIVLNTALRAAENAYRGGHTDRATILGAAQHVCAMMLRAQMDMKPSERAQFEVDYISLADPDSLHEVDAVDVARGAVLSGAVRMSPVEEPYEGEDLGHSGGPAVRLIDNIILPPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZAU1</accession>
    <name>A0A7D5ZAU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SRPK_5</name>
        <name evidence="11" type="ORF">G6M90_00g108470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987959.1">
        <property type="nucleotide sequence ID" value="XM_066131754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZAU1"/>
    <dbReference type="GeneID" id="26243386"/>
    <dbReference type="KEGG" id="mbrn:26243386"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="88"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI74627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="463" mass="52084" checksum="92AE1658CF0E590A" modified="2021-02-10" version="1">MGARRMLHSIPLLSSRPTLHFSNAISRSVSAVSRPFSKSSESSPPRKFPSTGFELIDSSEKVEEERLPFYKRDEYYPMKIGHVVYGHYQIVAKLGYGATSTVWLSRDLRNQKYWVLKVHINSLKYNHELAVYRHLAHHAEDHPGRNHVREFHDSFTLKGPNGNHEVFVMEPLGMSLRSLQGIQRDGAFPEQLVIGALAQVFLALDFLHEAGIIHTGAYSEASPNRVNHYSVILPEGAQLIGQLLDVHSDNLLIGIVNKSIFSTVEENEIHKPSPRKVIGDAVTQVSQYMLGGKGPLILCDLGQARIGREHRGNAMPVPYRAPEVILNMLWGNSVDAWSAGLLAWDLLRGESLFNVYDHESRELNDAHHLAAITALIGPPPPELLQSSEVSRKYWHQNGEWKGPVPLPPKKDFESLIGDFIGVDKENFVSFMECFIAWLPNDRLTCLQGHFHPWLKTEKNPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBF9</accession>
    <name>A0A7D5ZBF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g091920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987374.1">
        <property type="nucleotide sequence ID" value="XM_066131410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBF9"/>
    <dbReference type="GeneID" id="26245305"/>
    <dbReference type="KEGG" id="mbrn:26245305"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000014">
        <property type="entry name" value="aldehyde dehydrogenase 22A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="89"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI72029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="611" mass="65381" checksum="80C05FDC58580BA3" modified="2021-02-10" version="1">METLSLERLASRWYDFSDYTTQRLDISTTTLQIGCAVAAILISSIVTRLLVLAHANSSPRPVRYRVPPPKLPETKTTVEQTSIKIPGTSAIQCYAPATGQFLGLVNPSTPDGIDRAVAAASAAQQAWRQTSFRERRAVLRSLMQYVLDNAEDICRIAGLDSGKTMVDAQLGEILVTVEKIQWTLLHGEKALRPSRRPTNLLMAYKRNTVHYEPLGVVSALVSWNYPFHNMMGPIIAALFAGNAIVVKVSEQTAWSSAHFAEVARGALAAHGHDPALVQAVACWPQAAGHLTSHPGISHITFIGSQSVAHHVAASAARSLTPVVAELGGKDPFIVLDSAAGDLARIAEVILRGTFQAAGQNCIGVERVIAAAGAYDKLVDMLAPRVRALRLGPDADVGAMISDASFDRLEELIAEAVEQGARLLAGGSRYNHPDYPRGHYFQPTLLVDVTTDMRIAQQECFAPVLTMLRAKSSSAEDMLAVANAPNFGLGASVHGSERDPAMGPIVRGLKAGMVAVNDFAAYYAVQLPFGGVAGSGYGRFAGEEGLRGLCNIKSVCEDRFAWMGIRTGIPPPVQYPVPSQKKGWAFTQGVVEVGYGDGPRKVKGLGKILGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ28</accession>
    <name>A0A7D5UQ28_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g027670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985665.1">
        <property type="nucleotide sequence ID" value="XM_066129994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ28"/>
    <dbReference type="GeneID" id="90967542"/>
    <dbReference type="KEGG" id="mbrn:90967542"/>
    <dbReference type="OrthoDB" id="10269400at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI63877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="106" mass="12348" checksum="690E627904EACD21" modified="2021-02-10" version="1">MEQAQDFSPLCRAWKETGYLLLPASFYNPSTWLLFHTFHDGTTVQISTHNFNKTYKNWPWATDEEKKHFEGTFVDLSGQGLGDSKTWVKYDMTIKEAKSMGFEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ76</accession>
    <name>A0A7D5UQ76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">des</name>
        <name evidence="16" type="ORF">G6M90_00g016070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548922.1">
        <property type="nucleotide sequence ID" value="XM_014693436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ76"/>
    <dbReference type="GeneID" id="26238366"/>
    <dbReference type="KEGG" id="mbrn:26238366"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QLI63978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="165" mass="17613" checksum="E913C7ED288A58F7" modified="2021-02-10" version="1">MNSLRLARAAVRARPAAFRAVSQRRTYAEAVPDKIKLSLSLPHQSIYRSQDVVQVNIPAESGEMGVLANHVPSIEQLKPGIVEVVEESAGSKQFFLAGGFATVQPNSTMSINAIEGYPLEDFSAEAIRAGIAEAQKVASGSGSEQDIAEAKIELEVLETLAAHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ95</accession>
    <name>A0A7D5UQ95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mug66</name>
        <name evidence="4" type="ORF">G6M90_00g013410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549180.1">
        <property type="nucleotide sequence ID" value="XM_014693694.1"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI63931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="199" mass="22878" checksum="AFB66BDAFE24C4DF" modified="2021-02-10" version="1">MDRQKDPPEFILDVFTDPRSVRDVVKGILHTIFFTRFFPSLTPRTRDVLDLTLPYVDDDELETMIDQRASALERQLDAERSSGVGNHAATNGGGRGQVAIQFFEKRRRKAWLSRGDEEVCWESWTLKVTVAEPRTESERAKVRRAMEQTLLTTVMKIVTFANAHKDHIPPITTQGGNPFPFKINIDQKETGWASRMRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQB0</accession>
    <name>A0A7D5UQB0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pre-mRNA-splicing factor cef-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cef-1</name>
        <name evidence="12" type="ORF">G6M90_00g024280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014692667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQB0"/>
    <dbReference type="GeneID" id="26237597"/>
    <dbReference type="KEGG" id="mbrn:26237597"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="53"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI64295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="781" mass="87638" checksum="AB971E4866F1C927" modified="2021-02-10" version="1">MPVVKGGVWTNIEDEILKASVSKYGLNQWARVSSLLARKTPKQCKARWNEWLDPSIKKIEWSKDEDEKLLHLAKIMPTQWRTIAPIVGRTANQCLERYQKLLDEAEARESSSLGLMGPDGGETQAPSADDVRRLRPGELDPDPESKPARPDTIDLDEDEKEMLSEARARLANTQGKKAKRKARERQQEESRRLATLQKRRELKTAGINIKVITRKKGEMDYNADIPFEKKEAPGFYNTSEEKTQNEAQLRGFDPQKLNLATKRKGDDDDDDDGDRKRRKNEKEGLSESQKAAIKAGRMQKIREAEQSSKRRPLNLPAPQVSEGELEDIIKMGKMGEAANAVARESDNDATRGFVSSYSTLNTGAPIRTPKAPEQEDHIANEIRNIRALNDTKSALLGGENTPLYEGAGSTGFEGIAPRKQAMATPNPLATPLRSGAGVGATPGRPGQTPMRTPRDTFSLNQEDGMPIPSATPRDIKMHDLAMRNQLRSGLASLPKPKDTEWEFEIPDEEQETARADDTAEEDAAERDRREQAIRAAEEELERRRRTQVMQKDLPRPSIVDLTMLLKKADSIQNAAEAMIARETALLMANDAAQYPVTDSQVKGIYKPIERFDDDALADARLLILSETKPRPNLEQIQDFFESRAKNSMLLGLGCYNDDEEEQEAAMRAAFDAVQDSIMASAEQGAKLEKKLALHLGGYQKRQKMLKDKISDATDALEKARNALSGFKTLAISEDVAIDRRLEALREEVMYVTKREREAQEEYRKARDELSALREDGRNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQE1</accession>
    <name>A0A7D5UQE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily multidrug transporter mfsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfsB_2</name>
        <name evidence="8" type="ORF">G6M90_00g024250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548156.1">
        <property type="nucleotide sequence ID" value="XM_014692670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQE1"/>
    <dbReference type="GeneID" id="26237600"/>
    <dbReference type="KEGG" id="mbrn:26237600"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="532" mass="58435" checksum="DC2C1915495541C0" modified="2021-02-10" version="1">MALTKQVSPRNPNDFPTLQLFLLAVVRLAEPIALTSIFPYAWALVKKFQIGNEQDASFYSGLLISSFSFAEALMGMYWGGLSDRIGRKPVLMIGCLGTMFSMVMVGFASNIWIALLGRGIGGLLNGNIGVIQTMVGELVTKPEHEPRAFAVMPFVWSIGTIIGPCIGGTFADPHESWPNAFPRGSMFERYPYLLPNLLCAALLLVSIALGFVLLEETHPDMQPRVLLPADTYVSEETPLIETSDAMKRPAVDLRAETYGTLRTVNEDDEYDRGREVYTQEKSGLTKVWNKRVVGFIIALSIFTYHSMTYDHLMPIFFEDDRIVNKNTSTLWAIFSSSGGLGLSLRDVGMIMAVNGCIALFVQAVIFPIAAERVGVYKLFLLVTVLHPVVYAVVPFLLLVPESLTFPSIYICLAIRNIFSITLYPLLLILIKEATPTSSALGKVNGLAASAGAACRMIAPPVAGFLYTYGSKINCTALAWYGSVVVAIVGSVQCFLVPRERNLEISEECASRPPCNEYNALTAEVSDEEQERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQN7</accession>
    <name>A0A7D5UQN7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">APS2</name>
        <name evidence="14" type="ORF">G6M90_00g023410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548214.1">
        <property type="nucleotide sequence ID" value="XM_014692728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQN7"/>
    <dbReference type="GeneID" id="26237658"/>
    <dbReference type="KEGG" id="mbrn:26237658"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI64259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="143" mass="16873" checksum="40E953BB5118B371" modified="2021-02-10" version="1">MLSFILIQNRQGKTRLAKWYAPYSDDQKIKLKGEVHRLVAPRDQKYQSNFVEFRNNKIVYRRYAGLFFCACVDTNDNELAYLEAIHFFVEVLDAFFGNVCELDLVFNFYKVYAILDEVFLAGEIEETSKQVVLTRLEHLDKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UR75</accession>
    <name>A0A7D5UR75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spherulin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g013660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549156.1">
        <property type="nucleotide sequence ID" value="XM_014693670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UR75"/>
    <dbReference type="GeneID" id="26238600"/>
    <dbReference type="KEGG" id="mbrn:26238600"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028884811" description="Spherulin-4" evidence="1">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29620" checksum="05FBD634F5BFFEE1" modified="2021-02-10" version="1">MRLLLTSALATTVSATGLILPLYIYPAATSDDGAANWAPVFNAAASNRDLSWLTVVNPHNGPGDTHLPGNNDINYIQGVTKLNTHPNIKPIGYVRTNYAQFSLDQVKQDVAAWKGWDTYSASNISVQGIFFDESAPNAPYMSALVGYTRAAFGRPITVTCNFGKAVADEFYDICDVVVAFESCLNCPGLPQYKDAATIQANIPANRMGKAAVILNYFTGTAFDGTFADATLVHRYFQTARNMGLAWAYFCSQDYNNLLAWPATIWEDVKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URT4</accession>
    <name>A0A7D5URT4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g026060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547975.1">
        <property type="nucleotide sequence ID" value="XM_014692489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URT4"/>
    <dbReference type="GeneID" id="26237419"/>
    <dbReference type="KEGG" id="mbrn:26237419"/>
    <dbReference type="OrthoDB" id="4366798at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="409" mass="46125" checksum="87DE20DD4026D811" modified="2021-02-10" version="1">MEDPTWAWPAWKFGMKRDDLFTTLHDQYNTFSFTLQDPEAFHHDVYEISRDAESTAEFHRMMADRRQMRLRELNESLETLAVEIIANPTLMGTDQWQYALQLFRTKSYDSILRYFASYLPEDYLDRHDTHSTSSASFSETDTISTVASSVNDAPSPFMTDDDLFPNGPVITAEPDAIKEKPHHSSHPQGPLSAPHSEDAQSEPSVSSPPSDAESNDYLTNPPSRSMSFSGSESGHLVSELIRRRCLEEDLNEKSRSDESETAFTFVCDSFEPIDVIEGQSHTPGGVVDFADEDEDIPTAQYPDDVFNSLDLTFSLTHPPSAHDTLDSDTPTPRPEAAAASYMEFRSVLSHSRKAPSYQRSPSPKCCLANRGAGSPVREVRRSPEESLSKIQKSVQDFSRRHPKTRRRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5US48</accession>
    <name>A0A7D5US48_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">J domain-containing protein spf31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spf31</name>
        <name evidence="3" type="ORF">G6M90_00g022390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548315.2">
        <property type="nucleotide sequence ID" value="XM_014692829.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5US48"/>
    <dbReference type="GeneID" id="26237759"/>
    <dbReference type="KEGG" id="mbrn:26237759"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="217" mass="25576" checksum="3A41FDE007B4098B" modified="2021-02-10" version="1">MAADDSKDDAAALSALELEAKEFDKDAEIDRILRAFRLDAYAVLDLQPGVAESDIKSTYRKKSMLIHPDKTKNPQAPDAFDRLKKAQTELMDEKHRERLDEAIADARMLLIRENKWTVDSPELKTDDFAKKWREKSKEVLIDNEHRRRRQMRAQMQEEGREQRKQDAELEERKRKRQHEQDWESTRDERISSWRTFQKGKTGGDGEKKKKKKLKPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USB1</accession>
    <name>A0A7D5USB1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g021660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986002.1">
        <property type="nucleotide sequence ID" value="XM_066129878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USB1"/>
    <dbReference type="GeneID" id="90967490"/>
    <dbReference type="KEGG" id="mbrn:90967490"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028931362" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12780" checksum="23A4E8EEE0CD538C" modified="2021-02-10" version="1">MQLVSHLMVLLAVSTTALCEPATSIMSEGVSYLAGGGGCYKKNQYLGHFVKDIVISGKCLDLAHTDAINFGTVDGWCWGYKSRKCEGLKKEMNFTLGCNKLSRHGTPMSILCRLPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USC7</accession>
    <name>A0A7D5USC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g007380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549772.2">
        <property type="nucleotide sequence ID" value="XM_014694286.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USC7"/>
    <dbReference type="GeneID" id="26239216"/>
    <dbReference type="KEGG" id="mbrn:26239216"/>
    <dbReference type="OrthoDB" id="4938577at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="58522" checksum="EF3D35D46AE0E158" modified="2021-02-10" version="1">MNTSLTDAAPLDKDRLGRLGQVQDYSKSKSPTCIKTGKDRGFVYSGTTKQAHISNSFCPPRHHHVAKGEVPSEKRPSMIVHSQPSFQPRPVAVTEAGYPDAVWKQRPPRKSFGSSRTSFTGRNRFWSEGSPRRPLISAPSDFRHLQSGSFQFPPDVSPSDCQPSPRQYQCHEDEFEEHESCFRPLELSIYSTDRHISPLLPHFEFPRITTPPPPPPPAYCAERSEDCHQLSLQRSNTSISFHVPRRHHVDASRSVTEEELPPQIPAKSRYRVRAYTGPEVEAIKERVASALIEVDILQKQIDNVIERQSIYVNSRPSTAHSIARVHDLEPMPSIPALPPTAPSFAERLNADVERPQTAPIKTSVNATLSHRKTTPEDNFRATMKQNQAMCESQILPPPLPLVLRPPLRKKKSFSRVSAWLFPGQDQGKTVGLDAVTNKPGPVKNKGGFYQIVSSKGTVGQRSCESIDSISTWQTGDEQHTTPSISSRESTPASKHEEHHEIERRATFGKNDARIGQPPVGVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USN0</accession>
    <name>A0A7D5USN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gsy-1</name>
        <name evidence="10" type="ORF">G6M90_00g004390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542089.1">
        <property type="nucleotide sequence ID" value="XM_014686603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USN0"/>
    <dbReference type="GeneID" id="26245120"/>
    <dbReference type="KEGG" id="mbrn:26245120"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI66015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="703" mass="79772" checksum="20503A0DB99BC4D4" modified="2021-02-10" version="1">MADGEPVRDVKNHLLFEIATEVAHRVGGIYSVIKSKAPVTTAEYGDRYTLIGPLNHTSAAVEVEEMEPTNPEIAKTMQAMKDRGIGMLYGRWLIEGAPRVLLIDTKTAYGYMNEWKTDLWNIASIPSPASDDETNEAIVFGYLVAWFLGEFVCHEKKRAVIAHFHEWLAGVALPLTKKRRIDVTTIFTTHATLLGRYLCAGSVDFYNNLQHFDVDAEAGKRGIYHRYCIERAATHSCDVFTTVSHITAFESEHLLKRKPDGVLPNGLNVTKFSAVHEFQNLHQQSKEKIHDFVRGHFYGHYDFDPDNTLYVFTAGRYEFRNKGVDMFIESLARLNHRLKNAGSKMTVVAFIIMPAQTTSLTVEALKGQAVIKSLRDTTTMIEQSIGRRIFERSLKWHEGDSMPDEKELISGQDRVLLRRRLFAMKRSGLPPIVTHNMVNDQEDPVLNQIRRVQLFNHPSDRVKVVFHPEFLNSANPVLPLDYDDFVRGCHLGIFASYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENSSDYGIYIVDRRTKGVDDSVNQLTSYMYEFCGKSRRQRINQRNRTERLSDLLDWKRMGMEYVKARQLALRRAYPNSFAGDEEPEDFIPGVEQKISRPFSVPGSPRDKSGMMTPGDFASLQEGREGLSTEDYVAWKLPAEEDPEEYPFPLTLHTKQPGGESPLPPAALNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USR0</accession>
    <name>A0A7D5USR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">URA5</name>
        <name evidence="12" type="ORF">G6M90_00g023850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986067.1">
        <property type="nucleotide sequence ID" value="XM_066129912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USR0"/>
    <dbReference type="GeneID" id="90967502"/>
    <dbReference type="KEGG" id="mbrn:90967502"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000008">
        <property type="entry name" value="Orotate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="58"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI65970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="234" mass="25198" checksum="9FD2165D3CE442B6" modified="2021-02-10" version="1">MSGQLASYKQEFLKAAIEGGVLKFGSFELKSKRISPYFFNAGEFHTARLAGAISSAFAKTIIDAQQNTGLDFDVIFGPAYKGIPLCSAITIKLGELSPQNLDTVSYSFDRKEAKDHGEGGNIVGASLKGKKILIVDDVITAGTAKREAIDKIRKEGGIVAGIVVALDRKEKLPAADGDDSKPGPSAIGELRKEYGIPIFAILTLDDIIAGMKSFASDDDIKRTEEYRQKYKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT71</accession>
    <name>A0A7D5UT71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">THP3</name>
        <name evidence="3" type="ORF">G6M90_00g021330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548414.1">
        <property type="nucleotide sequence ID" value="XM_014692928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT71"/>
    <dbReference type="GeneID" id="26237858"/>
    <dbReference type="KEGG" id="mbrn:26237858"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000006">
        <property type="entry name" value="Putative SAC3/GANP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="328"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI65332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="509" mass="57125" checksum="E3F3C2DD44665A69" modified="2021-02-10" version="1">MLPGWSASQQAPGVSQRTQPVAYSYAASPAFVPVQVRQGFSQYAPPTPPYPGYVPPSVGAQSPAQAEQPKPKTEWPESVRKYVQRSFLPENDDPTVSRAEVEAKLKETIGTAKENGTLYTIDWDAVPLPQALVKADRDALYNSGNHTPSSSESVAKSRKRKSSDSVDGGSNQPPWHNANSRSSLETRISYPSPDKRSTFDDNLAKSSKFQKEAASKRKRRFESEYKAVYRSPSPTPPSSGPIIGTSEVLEKRYLRLTAPPIPSNVRPVHILRQTLDLLKKKWRKEGNYSYICDQFKSMRQDLTVQRIKNDFTVSVYEIHARIALEKGDIGEYNQCQTQLRSLYSLGLKGNPIEFKAYRILYFIHTANRTGLSDTMADLTAAEKEEKPIKHALQVRSALALGNYHKFFQLYLDTPNMGAYLLDMFVARERLAALCNICKSYKPDVKLRFITEELGFESDADAAQFIIDHSGQHLLEDRSDNIVFLSGKAGQLFESSRSEAFRKVDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTU0</accession>
    <name>A0A7D5UTU0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g001900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542890.1">
        <property type="nucleotide sequence ID" value="XM_014687404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTU0"/>
    <dbReference type="GeneID" id="26244263"/>
    <dbReference type="KEGG" id="mbrn:26244263"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="374" mass="39759" checksum="DDB64F8B5F32436B" modified="2021-02-10" version="1">MSYYENAQWPTPSQNNWEHQQGTSTPTRAGASGPQPQDDFAFSYQFDEVDRAFENLQKSGKGYAMGARRKPTPKASLRSGAPIFTDGRVSHGSGPRSHPMNNTFEGPQGHNLHNFYASQRHQPSRGSNEAEQVMQAKRRMAAQRERELRNLHTEQQYQRNALTDAPQHTNTTPVNNNAKHMSEEETRELIARQRSALYGEGPFADKTSYVDETGNIRPGVPGQSGPSSIRGPSPLAFEAIGRVPSGAEVVTPGSASDHNATIADPGPRPQSTSSPHNSGPTNRAFDNAVGSQSRTSTSSPTGGSPPRDFVPGSKPGQSGATVAPIGTRPSGTPSTTTSGKRSTTPLASSSGGWGRGNGVWGQSSGLGAQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTU1</accession>
    <name>A0A7D5UTU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phosphoethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NMT1_1</name>
        <name evidence="9" type="ORF">G6M90_00g032640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine = phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25325"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:25326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25321"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57781"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58641"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:25322"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.103" evidence="5"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543195.1">
        <property type="nucleotide sequence ID" value="XM_014687709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTU1"/>
    <dbReference type="GeneID" id="26243996"/>
    <dbReference type="KEGG" id="mbrn:26243996"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000234">
        <property type="term" value="F:phosphoethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44307:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="281" mass="30640" checksum="8879E71D58CD7743" modified="2021-02-10" version="1">MSIDTGDTNTESNDNMASPNADTGIGNVALYNLGRIRRSLDALASKPKWDPSDTAGFDCMHYFGDGALEKACQRLGMQPGQTVIDIGSGFSATGRYFHKTCGVDVTGVELQAEIHELAEIITKRNGLAGGVRSVNADFTKLTVDAPVDYIVSFLCILHIPDREALFQKVAGSLKPGGKVYIEDFFARTTLDPSARDQLRDIVSCPYLPSREQYISHLTNAGFHGVRFEETSEDWAEFVHERAVRNRHEGTSEAPLTLFYDTVDALFASGQLGGVRLTAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTZ0</accession>
    <name>A0A7D5UTZ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g051350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539820.2">
        <property type="nucleotide sequence ID" value="XM_014684334.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTZ0"/>
    <dbReference type="GeneID" id="26247375"/>
    <dbReference type="KEGG" id="mbrn:26247375"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="285" mass="30684" checksum="3627E9413CE0EBB1" modified="2021-02-10" version="1">MAIAAVGQICSTASMKANLDQCVRLVSKAAIGGAKVLFLPEASDYIAHNAQESLALAQPQSTSPFVQGLCAAAKSHSVAIHVGVHEPLPQQPTSKLLNRALYISPAGDVVDAASYDKLHVFDYASLRESDTVQPGSGLTAPFDSPVGRIGSLICFDVRFAEPAVALAQPGPGSPWCRRPAQVLTYPSAFTLRTGRAHWEALLRGRAIETQSWVVAAAQVGRHNDKRASYGRSLVVDPWGEVRLRLGGTRNDEGEAEDGAVEEIGFVDMDMALWETVRREMPLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUK1</accession>
    <name>A0A7D5UUK1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Respiration factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RSF2</name>
        <name evidence="10" type="ORF">G6M90_00g041540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547499.1">
        <property type="nucleotide sequence ID" value="XM_014692013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUK1"/>
    <dbReference type="GeneID" id="26240062"/>
    <dbReference type="KEGG" id="mbrn:26240062"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000343">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="VerF-like"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="926"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI67256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1172" mass="126135" checksum="F080C441C5EE63DC" modified="2021-02-10" version="1">MSNPTTASAAAGTSNPPAAVATAATATATATAAAAAADDSASTITVNTKAPSANFPPPKTDKPRPHVCATCQRSFARLEHLKRHERSHTKEKPFECPECSRCFARRDLLLRHQQKLHQTSTPSSRPRNRRESASGAAPAQSRRKNSVAGVNAAGSGAAAAPMRPRANTISHVDGAAMQMLASANVSVARGMAHSRHPSLVGLPVHNLDHVFGGMSAALGQRGLQHGLPKLETSQVGSNDFDASGLRTAPPMAVFNPEFDFEGLFFGPGSTINPNALHYNDSPQSMALDQTSPFGQGLPDVAATQHFDDWVTGFEHQMSFNTNEHVIDGSSPSAISTTSQSGISDVMVDGSNHPAPAGTSTMWQPSVMGPPQMPNPFAMDLNGSVFPDLLSGAPLSPQPATQKINDPYFSAPPTSLSSLSTSVVSGINSQPLNPPLGFNAAQETPSSLNGGNHAASPVTTITDATRTAIVTILFHCLPFGSRKNPSLSSLGSPQIQSGGNSSSNPAINVPSTQDLQRYVRAYLTCFHPHLPFLHLPTLSFDVSPDSIGRSNGAGGNGCLLLSMAAFGAAYEMEHAQSRDLFDMAKKIVFFYLDERHKSDVRRADTRLSTISTDSKVQQNQAQSSTPLWLVQAMLLNVIYGHTCSDKVTSDIASTHCASLVSLAQSSGLISQGKGNVPTKQDVDMADTGDWTRISEQEEQREWLQWKSMEEHKRTVYVIFILSSMAVASFNHSPALTNSEITLDLPCDEEFFAAESGAAFASRGGVEAANHNRLTFFDSLGDLLRTNERQHSMGNSQPQFGSPMNTTDTPLTDLKPSTFGCLVLIYALHNYIWETRQRHQNRTWTNIETEKMHMHIEPALKAWQIAWSSNPQHSIERPNPFGLGPMSADAIPLLDLAYVKLFVDFGPAKAKIWQRDWDGMIEELSRGFETQDEARSPTCSSETGTDPSSNSVINPGFMDSPATQSSLNGMHADKPFGTGQDANGTGRSISRRERYLRTASFYAVDSLSMSDKLGVTFADKTSHELPMQTALCTAECAQVVAGWITALQERVGPYLGIVGQDHIDLSQVPAIILLEEEDIKLLDKVRDILSTAELKINMRLGPNATGTIGGHESVLSPDGFTGYACQILRLAAWMVNKSAVWPVAHIAAHGLETYANHLRVRAEKSVTGSMPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUW8</accession>
    <name>A0A7D5UUW8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein RTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">G6M90_00g037950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014691669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUW8"/>
    <dbReference type="GeneID" id="26239718"/>
    <dbReference type="KEGG" id="mbrn:26239718"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF28">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33024" checksum="5E8ABF3D883A410C" modified="2021-02-10" version="1">MADDKDVWMYNPSFALAVIGTIVYGLIFTAITYLTFFRYRAWYFTVVVVGAAVEVAGYVLRAYSARNRTILVPFVLTLTFTVLAPVFVAAGNYLLISRLIRAVLPPSHHRVLGVPGNRLTPIFVVCDVVSFLIQGSGSGIASSDNWQGEKEKIGRYVLIGGLSFQLVAFGLFLCVFRRFHVLANRMARPEAPTGWQQVVLSVYISSVLIMVRCIYRVCEFAEGMNGYAFRTEWLFWVFETLPMIGAIGIFVIYHPGRFLGQDGAAQPKESRSDESMELAGKRGWFRMRRVNGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW08</accession>
    <name>A0A7D5UW08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g040060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547356.2">
        <property type="nucleotide sequence ID" value="XM_014691870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW08"/>
    <dbReference type="GeneID" id="26239919"/>
    <dbReference type="KEGG" id="mbrn:26239919"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI67671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="646" mass="70503" checksum="C617653F803B4539" modified="2021-02-10" version="1">MSSSLQGSPPRPLSPILDKPRRQAITRACDRCRRRKAKCDFDNAVGTCSHCRDTNARCTFDLPLAKRGPKSKKSTDSSIPPESVSTFSGRRGIHHAPLVGHPSSSTAAATFKSPPSSSTTTPWESSAQLAAGAGLSPASTRDFASVASPPAAHGVSAVRRWRTLSRALSLRNKVLEQMVERCFGLFFEYLYPLTPLVHEPSLRDGLSIFTSQSSNSALQNAPRNGNDGLADTLPALNPPAWPGISPDVGSGPGGETLGCWHDATFTLITAVCAEAAFLLPKDLFPEGETVADLFLQASRDCLNSYLEADLENPNANSITIRYFHSNCVHAAGKPKYSWHIFGEATRLAQVMRLYDEAALEGLPPVESELRRRAFWIVYMGDKSAAILNNRPITMHKYSFETGVTTAYPTGMDNRSGSMASVSDVATPPDSHGSNFIAGFNANLKLWQAASDLLIQVRLFQDQKSIEFGAANRPSQALTESERQRLDSLFVQFITCMDDLPPYLQSYTFAAVGGAGGPIAEAKQFVIQCANLQVSFHCLRMVITQKFEDIAFFTPGAEQADLRKTEIVRDMLRVMHEAPFWSLQVNGEPYVEKIRLIGATLLSIIHRNQASPLAARARSDFSVLLDILTRLDSKASDALKSTSTWAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWB0</accession>
    <name>A0A7D5UWB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neutral ceramidase</fullName>
            <ecNumber evidence="4">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDase_0</name>
        <name evidence="8" type="ORF">G6M90_00g038800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547236.1">
        <property type="nucleotide sequence ID" value="XM_014691750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWB0"/>
    <dbReference type="GeneID" id="26239799"/>
    <dbReference type="KEGG" id="mbrn:26239799"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF20">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029002382" description="Neutral ceramidase" evidence="5">
        <location>
            <begin position="36"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="571"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI68515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="742" mass="80292" checksum="5A8CA40E1AA6A6AB" modified="2021-02-10" version="1">MAYSTAGPSQGLGLSRSSIYSLFFLVALCVLSTLAACGSAAATGDKYLIGVGKADITGPVVEIGFAGYANLDQKGTGLRQRLHSRAFIVADKNNPDDRFVYLVLDSQSGDTATRYGVLDGLKNLGAEYSIYGHNNIALTGTHSHAGPGAWFNYLLPQITTLGFDKQSYQALVDGAVLSIKRAHENLQDGYLDAGTTRVKDGAINRSLYAYLANPESERKQYEDDTDTLMTLLRFKRASDNKDIGVLTWFPVHGTSLLGNNTHAAADNKGVAAWMFENAMKDNSNAADGFVAGFSQANVGDTTPNVLGAYCDDGSGQQCSLENSTCADGKSQSCHGRGPEFRALDLGVKSCYEIGRRQFAGAQTIYNSLGTSGTPIEGSSVKAFHFFHDMRFWNFTLPSGKQAQTCPAALGYSFAAGTSDWPGAFDFTQGDSGEPNANPIWRVVSGLIRTPTEEQKACQGSKPILLDVGEMDEPYAWTPNIVDIQVLRVGQFLIIVSPSEATTMSGRRWKAAVATEASSFLPQKPIVVLGGPANSYSHYCVTPEEYEIQRYEGASTLFGPHELDAYINLTVSNMHYLHPDSKDTPDQGPLAPDNRGKALSFITGVVVDGAPIGSSFGKVVHQPSASYQIGSVVNVTFQGANPRNNLRQEQTFAAVEQQGSDGSWTRVRDDTDWFLVYSWRRTNFILGYSEVDISWETYGNAQPGTYRIKYYGDSKPPIGSVNPFDGTSNSFKLTGGLTRQLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWT6</accession>
    <name>A0A7D5UWT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g060450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544615.1">
        <property type="nucleotide sequence ID" value="XM_014689129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWT6"/>
    <dbReference type="GeneID" id="26243027"/>
    <dbReference type="KEGG" id="mbrn:26243027"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459:SF1">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36459">
        <property type="entry name" value="ORF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="450" mass="52009" checksum="CDBB665536FCD6E6" modified="2021-02-10" version="1">MEEYIVFDKALTKADHVVLQSLARDIKTASSVRSRKSKGRDSDCDSGIGSEESSSSGDEAKAFPPQDDATTDQDIAALKASRNPKSAAFEPTIVLSVDDCDAHLHPLLNNYLLQPYIQLARRIVRHETDVAMLTHLIIYFTTSVPSALVLFRHFTYTHAVLHFVMQMYYVGTYTLMQHQHIHQRGILAKTYGLFDRAFPYILDPLMGHTWNSYYYHHVKHHHVEGNGPDDLSSTIRYQRDSVPDFLHYVGRFFFLVWLDLPLYFLGKNRPGVAIRAAGSELATYAYYYFMYRLVGTKATLFVYILPFVMLRMGLMVGNWGQHAFVDSDEPDSDFRSSITVVDVASNRFCFNDGYHTSHHLNPLRHWRDHPISFLEQKHTYAKEGALVFHDIDFLMITFRLLRKDYEHLAKCLVPMGNQIHLTMDGRVKLLKRLTRKFTEEEIAEKFRKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXC7</accession>
    <name>A0A7D5UXC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g053470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986734.1">
        <property type="nucleotide sequence ID" value="XM_066130563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXC7"/>
    <dbReference type="GeneID" id="26246832"/>
    <dbReference type="KEGG" id="mbrn:26246832"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="183"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="704" mass="78804" checksum="10789347633008A0" modified="2021-02-10" version="1">MSSKSSARGLFKEFGRKEEEGIGAQNNGKTPQNPADTPMVSQLERKAETWMTSDPSHLRNPNDGHPIEPQASEQAKPTVQYTRSALPTTSIVHNPSQNDSPRPSAPGTTGEHTNSQAPRKQRYRLSLTSLSIQFSKSPEPYEYAPLPRGKYTRYLVLQPGKDKEALLCHLHTCTLTDLSEVEIISYVWGSSNKTKRLWCAGKTIPITVNLWDVLRRVRLPDAPRTLWADSICINQEDPKEKSEQVALMGLIFGGAKRTLICLGPDNGQGSLVESLLGDVNQMIQQFGSWDQIPPLGQDDPMAKDPRWGFLGNMIVSPWFSRVWVVQEAALSRDARVLDRPDSENFVAFLARAKRLRCSDARDRVYAFLGLRMAQVGLGSGPIVVPDYQKPNDEAFHELALEFLKHTNDLCILSAVDHTSETLKSDLPSWVPRWDYVASTDQFGLHDVPYNASRGMKPTKLSFVSSAGLRLRGLILDRIHFRSKALPKGLPTALCTLWEGFSLQNQNSLTILWKVVPLPLQNLLVLLAERIPDKNKDFLVNLWIYLAKTRHKSAYDDGERLLAFIKTLRRGAHEGRWALTADEAAFCLRLCRKSASLGYANMAEIEQVAQGSDGRDFRLHTSAWCTGRRFILTSNGYYGLAPEAAEEGDVCCIIPGLRVPVILRGMNKEQHYRLVGEAFIFGLMEGQGIANRENWGLKEEDVILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXG6</accession>
    <name>A0A7D5UXG6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylserine decarboxylase proenzyme 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">psd3_0</name>
        <name evidence="4" type="ORF">G6M90_00g064550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540089.1">
        <property type="nucleotide sequence ID" value="XM_014684603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXG6"/>
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    <dbReference type="KEGG" id="mbrn:26247125"/>
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    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="403" mass="45460" checksum="6BC0FBE3CBF02812" modified="2021-02-10" version="1">MALHQVDPLVQDFINVVNGRKGWKKNFETAITTARERAEEDMNRQEIYNLPDFFRYVNDFLHWVPRVDGPGDEVLQKLCVFYWVFEQPSVRDYQSELDPDNTSGPLTFMSYWLVNYAQQMGSFLDRPESLTTETLETFYKNPKYNDGASQWLEPRGGWKSFNQFFARHLKPGSRPIAAPNNSKVIVMPADSTFDNWANIVNGVVTFPDGTAEVKLKGISWKVSDLLQDSDYRDRFQNGVFMHSFLSTNDYHRQHASVGGKVLEVKNIQGQVYLEVDVSSERGGGLVPIRPLPLPRRRSGPGSGPERGIVPPDRAGYQWCQTRGLVVIDGGDVGFVAILPIGMAQVSSVVMTAQVGTTLAKGDEISYFQFGGSDVVVVFEKHVTFVENPSRRHFKMGEKIATFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXH8</accession>
    <name>A0A7D5UXH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g057170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544303.1">
        <property type="nucleotide sequence ID" value="XM_014688817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXH8"/>
    <dbReference type="GeneID" id="26242715"/>
    <dbReference type="KEGG" id="mbrn:26242715"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="119" mass="13070" checksum="4AC1FBAB5A0D2659" modified="2021-02-10" version="1">MAKSSRSSTRKENNRRKAASVFSPAEVARNERLSAKLLELARQPKPESSDVNMDANASEDVAEEVGSAQAGDDTGMEIDSKPSKSRIGKKRIDKRKQKKSSIVFAKYSDKAAKKQKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXX1</accession>
    <name>A0A7D5UXX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CDC34</name>
        <name evidence="4" type="ORF">G6M90_00g062750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542607.1">
        <property type="nucleotide sequence ID" value="XM_014687121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXX1"/>
    <dbReference type="GeneID" id="26244556"/>
    <dbReference type="KEGG" id="mbrn:26244556"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="227" mass="26113" checksum="FBF019EC80193367" modified="2021-02-10" version="1">MAQRRLMQELQALEKEKWVTIETDETNLLRWKIGLWVVNPDSIWHGAYLRADMRFPTEYPYQPPTFKFLTKNICHPNVYADGHLCISILHRPGDDEQSGESASERWNVLHGVESVLRSVLLLMDDPEINSPANVDASVLYRDKRQEYNSRAKEVVDRTQKDIPSGARMPTATDLAPTLVKPVEDDADFWNMSDEEEDFGGSDSEEDMGDFEEEDDDDDEDDEEDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UY79</accession>
    <name>A0A7D5UY79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Increased recombination centers protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g064470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540096.1">
        <property type="nucleotide sequence ID" value="XM_014684610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UY79"/>
    <dbReference type="GeneID" id="26247132"/>
    <dbReference type="KEGG" id="mbrn:26247132"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028970822" description="Increased recombination centers protein 6" evidence="2">
        <location>
            <begin position="35"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="40715" checksum="0AAD623C7E0CC21F" modified="2021-02-10" version="1">MALAATKSQTSRRCLQSLMRLFCCISWWWLAARTRETHDVGSSPTIHGQPRPASNFNPPSPITITMDVAHPRRILAVSLDSQADQLGRVIKDLTGSSPCSPSPSLAGTTHNLSLKTQYYTATVPVWLDLIASPSDWSASFLSDEAAEVLAVLGGLVLIFSLPPSTSSESIDRVRDVIHHVGHVVNNGLGGWEWDGVRLAVGVGDSDAQEWDELCAEAGLEFVQIGGKQLHLNEFGEKTGISRVKEALESNDWAQDAPSDFGDFEDASDAGEGEGGHLDPESLDFGFDRADFEGLKKAIWEARPGDQEPSAPTAGSGATSKAEADNQGDTQDELGHEDVDKVEGMMRKLQAVRDAGEGLPEAQRKRMAARAVGEVMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZ83</accession>
    <name>A0A7D5UZ83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein 6, OR allele</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">het-6_8</name>
        <name evidence="2" type="ORF">G6M90_00g076880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545415.1">
        <property type="nucleotide sequence ID" value="XM_014689929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZ83"/>
    <dbReference type="GeneID" id="26241448"/>
    <dbReference type="KEGG" id="mbrn:26241448"/>
    <dbReference type="OrthoDB" id="4932447at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF77">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="616" mass="69910" checksum="DFBEADAAE2DE2738" modified="2021-02-10" version="1">MQSTVEYKPLQPDSGFRLITLQPSSDFSSPIKCELHNVELHNHPPFEALSYVWGQTTETRPIQVGHGMFNATRNLETALRHLRLPDRPRQIWADAICIDQANHAEKSNHIGYMSQVYQRCATDLLWLGGDAKMLQDAASSMAHFGSLFRLEDELRQRWLDLSDEQTQTLERMQENLRHLFATPALWRRVWIVQEVAFASSLLLVAGHATLPWTVVEDFLDVDVYIERYGVPDAFHGPFSHDMSIRSWASGAIAYPQIMCHQRRVVRDEVQANEPSSMLDVLSRFRYTDATDPRDKIYALLSLTSNRLDIKVDYSLSTRAIYIDCMKRLMEHDRNLDLLCQSAWQLYGNDSRSSDLPSWTIDFASPGQTSILFAQRSIFNAGGAEVDLPLSVSEGTLQLAGYEIDTLSHVSRYSPQNQNAVPYPPGANHCLQWMPDDLIRAAIRNGNSSLSSFLKTNHPDASACDVPNFPASFEAFWRTMMMDVKRYPMARLTSADIEELAPRFTKWITTPLDSNRDIDIDFRVQDAVFEWYTWDFAMTKGGIYCRLPHGAQDGDWITVLKGAKVPVVLRPVPSGDGGANEANSDFLFVGPCYVHGFMDGQVFEKSRGFVERTFCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZA3</accession>
    <name>A0A7D5UZA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g067720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540529.1">
        <property type="nucleotide sequence ID" value="XM_014685043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZA3"/>
    <dbReference type="GeneID" id="26246636"/>
    <dbReference type="KEGG" id="mbrn:26246636"/>
    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028945938" evidence="1">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="261" mass="28015" checksum="A1F1D476FFFE034F" modified="2021-02-10" version="1">MKTSPLMLAGLLGLAAADPIKRQPATPTPAPKKTIPGHLAYIPWKVDKAPADGLQDVTFPISMKDSIRERGWYFAQNFQFHGKSGNAYIGVQPRPANSKGPVDHAAFSSFMPGTKSTDRNCSPGADGGPGVSCSVQITGTDDHSYDLRVENIGNTTWKGTMVNTVSKVETHIGSWTLPAGAGGMKGNYIGFFEWWPFNDRSKPPTCNLLKRTTVAFGPPRTSTANAGAGSLGNPYEVYECKGKTDYKTKKVGDNVEISLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZU2</accession>
    <name>A0A7D5UZU2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mono(ADP-ribosyl)transferase SpvB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">spvB</name>
        <name evidence="5" type="ORF">G6M90_00g066740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987016.1">
        <property type="nucleotide sequence ID" value="XM_066130839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZU2"/>
    <dbReference type="GeneID" id="26247624"/>
    <dbReference type="KEGG" id="mbrn:26247624"/>
    <dbReference type="OrthoDB" id="4936998at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003284">
        <property type="entry name" value="Sal_SpvB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03534">
        <property type="entry name" value="SpvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028906536" evidence="4">
        <location>
            <begin position="18"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI70471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="867" mass="98025" checksum="06A27C7507782DFD" modified="2021-02-10" version="1">MFLSVLAASLFTTASLAREIRSLHPVGVTVVSRDEDLLEKYRGQVTRLHDAISNATQCYTDFIDNLHKAEPDTLHTINACGDKNEAARAELAATHEIARSPAFPSDKLFSAQLPDVLDSRTSLQGPWTKDLQDRVHQLTLESLNAVEASKRAALLPEYRKHVTALYDHLSKAVTCYEAYDNNVQKPGANPDSIDACDTEYDAVARSLRDARSTAYQPDFPDGNWLFEAKIPDMRDNRNQKKLDELRDAAKHAFEIKDQAKLVKNYHEEVTDLQRRLASATKCYVDYIDHIHREDITDEGYKSRADQACNEAYRQIQAKLTEVRAAASKPNFPGASWLFNAHLPDITDGRAELQSEWTKNLEGKLRELTQAADRADRAGIQADDKLTQFNATVLQEVVPLVNKTAMETAEVLVKYVALNLLTQGKTAEDVKDAANKALLGFVKGLGHDMVDDEYILFGAEDLVPLKEHDGNGHWAVREPTLRTLNGEEYSVKRYRPRAEGLFSVIEHWTKNTGEIHWRSISKHNVTTLYGTNNESRVFDPEDPDSSKPTRIFSWLITESFDDNQPCEHNRTETARYAAWYLKRIKYGNRQSRFVQPIPADTNWMFEVVIDYRDHDFDRPTPTSQNPWLCRNDPFSVYRAGFEVNVRHYRLCQRVLMFHRFPDEVDIGVNCLVSLTDFECRSTRGVPSDIKLGNPTASFISSVHQSGYIRTELSLQSLGNLPTGLGSDKYHWVNLDGEGIACVLTEQGNTWFYKRNFGDAELGPLEIVAQKPSSIPLNGKSQLLDLGGNGQLSLVDFLVVTPGFFKKIANEDWSSFTPFKFLPNIRWDDPTLLVIDLTGDGRADIITSDNQVFTWYSFLAEDGFALIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UZZ6</accession>
    <name>A0A7D5UZZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g057610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544342.1">
        <property type="nucleotide sequence ID" value="XM_014688856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UZZ6"/>
    <dbReference type="GeneID" id="26242754"/>
    <dbReference type="KEGG" id="mbrn:26242754"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="879"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="784"/>
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        </location>
    </feature>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1084"/>
            <end position="1108"/>
        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
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        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
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            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1155" mass="124857" checksum="8C82EE90A68AFE0F" modified="2021-02-10" version="1">MDSPPKRMTRARAAAKASDAAAKSTKIVTAAAKARSLSKATASTKSTAAKRKTRADENDDGDDTLRVSAARRTTRTGPRKAPGNEESNTVAVMGPSSNTSTCRGGAKKLAADSSNDNAGSSRLRGRARKAPLQEPEPIAKRPTRTRAGNDTKEAQEEAKTTMKKSVKFQGAGKENLGLASKAKGAGSMGGLRGRPARRGAATMPKPQPKTSQDSDTGPKKPLSPKKVTQMPISRDEECSDDELAGGDEIKPSIKTSVKLSAYAPINQKSLNATSSQQEDNAMTDVEELVAPPETTTLTSPPRRPPTSPTKESLTSPAKRPCGKVQLPGSLLKPRALPSEDQHNQSSLLYSPAKRPPSPIKGSKFPPMTAGTPLHGQPPLKSSLLQSPAKRAMPGFRPVTEELNGKNAILTRTPRMQPIVVSCSSVSTSGLPSQLLLAEEFHDGETGDIGDDPFTSLADSPRFPGRMSAVLPRHADPLINADDIEDEEEDEKVYPIGRSAPEEMAEADSYEYIRNGQVVTELFETDREICEDGAMVLGEETDGHIGKPEIQISNAAITATPATKRGARFQLRGSVLDACRDFASDFESEDDLSPLKQLPAHHSRLDRRSTNGRDMTHAAPRDSRRSTLGLTSLTEKFGAWASASPTKMTKDQSSVVGGTHDGNITSSTAVLEMTLQSEASPMKNSFFEDEILVHADLESPRQHTESEIGQRTNDDAVTMEDIAMTNEDIALAAEANNMQLMPQNVDDDRETQHTEEALSEASQEYGDENQLPEDTVLPSARYVTPVTPTRPSQQKKPYFTTTKVPLKPADDSEPSPSKKRSFSAKSVGHLPRSATVISYSPTKGKKRASILPAYDPFSTPAKGDLWSSVGTPGKTPCRDINPGLLRGAVVFVDVHTTEGADASGIFVELLNQMGAKCVKTWNWNPSGSLTSEGALSSKVGITHVVFKDGGKRTMEKVRESNGVVHCVGVSWVLDCERENEWLEESPYYIDTTFIPRGGARRRKSMEPKAIANLNGTIISGTNNPSKTPNTPRNRRESTMWMHTPSDQGDLDDEDLEWSCALLTPVPKTPAPEAIAKYAAELPETPTSEDLSGIMSPSKQSFLTRTCPPKESKYRELGKGVLSREKDEQVMLRLMAARRKSLQFAPKVGSPLAKTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V021</accession>
    <name>A0A7D5V021_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Guanine nucleotide exchange factor LTE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LTE1</name>
        <name evidence="6" type="ORF">G6M90_00g071750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545884.1">
        <property type="nucleotide sequence ID" value="XM_014690398.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26241917"/>
    <dbReference type="KEGG" id="mbrn:26241917"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="349"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1522"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="637"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="979"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1139"/>
        </location>
    </feature>
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        <location>
            <begin position="1325"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1117"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1339"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1402"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1436"/>
            <end position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI71454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1769" mass="194502" checksum="6F75D2A4B3DB4A62" modified="2021-02-10" version="1">MASSSAKETSSLQPTARKWTARAITRGGSTASKPLVPFSERRSQEEKKQTEAETDRWDIAPDGGSAGREGRQFTVANVGNNGRIYLRPSVRPAHLRYPQPNFTFPITPPSTAVVDSWNPAEKTSQDDNKKGDDIESNFQTTQWTPTTSATPLAGDKQILADTETPSRPRRHKRSMSDSTVHEASTSKDQESHAFKISISKLGDRDEHRPRTMDDLDAMTGTPMLNVNIPSWRLGTPRFSIRGTPMIRSSSYAPTEDLHSSSTSDLKSSSRIPTVPIQANPTRKPSPLAVPEHCSPLVAQRGVAGLPSPRLSRPMRSTYVSTHLVIQPAMFTDLTLKPACNDRSIVRYSPAGAVTAATPPRLVAEITSPCFLDYELISDFFLTFRSFLEATDLLRMLVARLRWALDRDDEIGMIVRVRTFVALRHWILNYFVDDFLAEYGLRVTFCNLLNDFVDELCQDIVSSRVQLKILAELKKCWRRVCAQYWDAVEFDDLLGPEVVITPGGIAGSRDPNLDPSALETQIIGQQQTPPPHTVQPLQTSTNLNAASLPGEIPKAMQVGDFVVLDNRPGTPDYHNGNPVHLEYGPNSPHSLASMDIVSCSFPSKNMRALNPNTTQLMAAHPVPSSSVGIASGPIATTPKALVGKRVRPTQTHKRNNSLSDSLRDHNSDKASSTDQEAYTTAPSGGSLVRGNLLPPGHAFVDVESHHRCGHAHRQTTIVQQKSHNFSKERVSGGAMSGHGMRKLLRGVRKALKTKGQGLYSGQANLTDIPSVGPRGATTNRLPGTAVVPQQLSRHNGSRPPVRIDLLGAEVAEDFKKAIREEEAALAAAADSEQPSDVSLHPPNSAPLLSTYSNYSAAHMDSSALDALVLNQKQRPVSDMGITVGSKSIVIVDDTVPFEMPSIHGVFGSENQSIDTFADSFIRHGTDPTPPNTPPEQSQVGGTPRRSSCLLNQDIGRQPFVEDDILPPFIPDLTTLEGSLSTRVSEDQARPPLAVKRQSRQHPPLSGGAVRLHRRTRSSKTHQSLNSILHRRVTSFGSASIPPTIQSSDATAASGELDSIHQSQASMPAPLRVLRRRPGGDLKAATKVGDLDRSTVRRSQSVGSLATFSESICSSYMLSTRPNSAGKSDQSKGQETSGRTEVFSLGQLTEKPQKRDLSLFSTHSSKPIMRPSFEAEAQKLAQIPDEEDDGIESALLKLEGKFPKRALKLSIIGQSPDAIRNETKGKRQQEDVTNVNDPEFNTENANEAKRLHNIEPYSMYQLTKQPEHLQAVPLEQQSEKADRAVRVLSSFLSVSEASQDSYCSIPLLERELGDEISKISPRSWTERSILRGSDDEDSGSEQEQVNDPNDATHSSFDLVEKTQSIERIKPGETVPSITSGMEDESFLRDDSANNTDLSSELSEDELRARDTKGHASPLLDHGLPSHPLAQDPIDQRPKTSSGPISPTQALSMAPKSYDATRTFNTWPRKPLPPTPELTPIVSCPDSPRSTNEMARGNALFDSAKPGTSASPKFSVHLPFILAFDSDTLAQQFTLIEKDALNEIDWKELIDMDWKNSASSHSRSWVDFLRNTDAQGVEVVIARFNIMVKWAISEIVLTQHAEERARCIIKLIHIAAHCRRYRNFATLAQLTIALSSNEISRMSKTWDLVPENDLKTLSDLEFLVTPSRNFHNIRQEMEMGSDSGCIPFVGIYTHDLLYNAQKPSEIASSPSTAPLVNFERCRIAASVVKTLLRLLEASTRYTFQPIEGVTERCLWIGALSDDDIRKHSQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V074</accession>
    <name>A0A7D5V074_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">G6M90_00g071930</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545868.1">
        <property type="nucleotide sequence ID" value="XM_014690382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V074"/>
    <dbReference type="GeneID" id="26241901"/>
    <dbReference type="KEGG" id="mbrn:26241901"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="435"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QLI71097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="766" mass="85951" checksum="71D6157132283FB4" modified="2021-02-10" version="1">MVQSAILGFPRMGVNRDLKKATEAYWGGKISQADLLAEAKRLRLAHWKIQKDAGVDVIPSNDFALYDQVLCHIQDFGAVPERYTKDGLDNVDQYFAMGRGHQKGGIDVPSLEMVKWFDSNYHYVKPTLQNNQTFKLVDSPKAVVEFNEAKEAGIKTRPVLVGPVSFLHLGKADRGQTVDPIDLLDKLLPVYEQLLVKLKEAGAETVQIDEPTLVFDLPAKTKAAFKPTYEKLASLGDKIPKLVFTTYFGDIVHNLDLLPKDIYAVHIDLVRNPEQLETVAAALGPKTILSTGVVDGRNIWKTNFKRAIETVESAIQKLGKERVIVATSSSLLHTPHTLASEKKLDPEVADWFSFASEKAVEIAIIAKAVTEGPAAVREQLEANAKSMQARATSSRTNDPKVKDRQSKVTAKDHERLSQFPARIAAQQKKLNLPLFPTTTIGSFPQTSEIRVQRNKFTKGEITQEQYDKFIEEEIKQNVKIQEELGLDVFVHGEPERNDMVQYFGERLNGYAFTTHAWVQSYGSRCVRPPIIVGDISRPAPMTVKESKYAVSVSSKPMKGMLTGPVTCLRWSFPRDDVHQSVQAQQLALALRDEVVDLEKAGVDVIQVDEPALREGLPLRSGKERDAYLEWAVNAFKLSTAGVEDATQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLRVFVDSAYPRHIGPGVYDIHSPRVPSEQEIRDRIEEMLQFLKPEQLWIDPDCGLKTRQWKETKEALVNMVNAAKFFRTKYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V0P7</accession>
    <name>A0A7D5V0P7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Disulfide-bond oxidoreductase YghU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yghU</name>
        <name evidence="5" type="ORF">G6M90_00g085180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541075.1">
        <property type="nucleotide sequence ID" value="XM_014685589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V0P7"/>
    <dbReference type="GeneID" id="26246064"/>
    <dbReference type="KEGG" id="mbrn:26246064"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="272" mass="30924" checksum="6C9B25B1D68254C2" modified="2021-02-10" version="1">MAAKTDIVLYTASTPNGIKASIALEELGLQYKVSQPSPRDKSADKEDSGSQRQVHAIKMMENEQKEPWFLDINPNGRIPALTDTLDGNKIRVFESGAILEYLVDRYDKDHKISYPRGTAEHWEVTSWLMWQMGGLGPMQGQSNHFKRYAPEKIEYGINRYGNETRRLYRTMEDHLAKSPHGFLVGDRVTVADISCWGWVASHTWAGVSLDEFPHLDKWLKTLLRRPGFERGRHVPNPHTAFDNDGLTEEELDTKAEGARNWVQGGMKADAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V119</accession>
    <name>A0A7D5V119_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g085220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541079.1">
        <property type="nucleotide sequence ID" value="XM_014685593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V119"/>
    <dbReference type="GeneID" id="26246068"/>
    <dbReference type="KEGG" id="mbrn:26246068"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000073">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI71617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="563" mass="65145" checksum="B2B6D9E0366AF4B9" modified="2021-02-10" version="1">MSSLPPDPYKILGVSKDAQTSEIRSAHRKLVLKCHPDKVQDPALKAEKQDEFQKVQQAYELLTNDRERQKYDDKAKLEELRKQFQAQANISTPRSTRYSGPDEARGAESRASPFKASVSPSGVKYSYNGLSDEDLGRGPRIFEASPRSSRREASYEKASERRSDREREREKEQRDRERRRQQEDALKRAEKEAKEARRAEKRAREKQNAKDMKRQSEEKKRHAKPYIEPFDEEPTVVRSDKKKSSGSRNYDEKRDRSSGRDDIQRDAHPPRPQRSWTAKEEYAHSYIKASKAKSTPALKRSATTHYIRSVQPPAPTPPPIHGQSGPFAPPDDDDARRSSARPRRGSGDDPRLSRERSYRAPSRDAMDDPPIINVSPSARHTAAFFTPSSPPRGDRLPRTKTMPHESVSYSRSPPEIQRSQTFHMFESADHPRGRDRSRMQSQVELEMDDEDRYDRRRDRKHRSRRRHHSPDPMRTENVSRYRVERNTLDGAYNTRLVEPDIRESYASYYHPQDSRPSMPGRETSYSNSGGANFPKVKTTKAYGYEDVSYSSYGRPAREFVYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1D3</accession>
    <name>A0A7D5V1D3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g089240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541587.1">
        <property type="nucleotide sequence ID" value="XM_014686101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1D3"/>
    <dbReference type="GeneID" id="26245450"/>
    <dbReference type="KEGG" id="mbrn:26245450"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI71857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="165" mass="19123" checksum="8C0672A99C955D7F" modified="2021-02-10" version="1">MDRHQQEFQTHIVVHRGSIQDTSHQRRIGLWFVPCERGSQYYFHVKRAIHNYQFEIKRDWDPTCTGSALPLIYIGRTDKLSASELVKILTDVPIENHNLEFNGQQWIWEALTFLVSKGHLTRRQLDDGFEQMLVTVLQGSADELPETHHGHIRSSSSSNDTTDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V1X8</accession>
    <name>A0A7D5V1X8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-peptidyl aminopeptidase BapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BAPA_2</name>
        <name evidence="2" type="ORF">G6M90_00g094420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540806.1">
        <property type="nucleotide sequence ID" value="XM_014685320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V1X8"/>
    <dbReference type="GeneID" id="26246419"/>
    <dbReference type="KEGG" id="mbrn:26246419"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000004">
        <property type="entry name" value="Beta-peptidyl aminopeptidase BapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="386" mass="41454" checksum="D20143F9C4FEC441" modified="2021-02-10" version="1">MAGTDKRGRDRIRNILPDIYLGRWPTGRLNSITDVPGVLVHTQSIEPDDHVHTGVTTILPRPDWHEYSSFAGVFRFNGCGEMTGSHWLNETGLLCSPIIITATSSVGEGYRGVTEYVYRHHRREGGEVDLFLLPVIAETYDGFLSDPARFAVTPEHVMQGIQSATADAVPEGNTGGGTGMICHRFKGGTGSSSRVVKGYSADGNGVDYTVGVLVQANYGLAETLCIGGVPVGRILQREGKLAKPADAPEPRKDGSIIIIVSTDAPLIPIQLQRLARRATVGLGKVGGYGNNNSGDIFLAFSTANKVPVGDVSMQSKPGFNDFTPAERVVSMSDNDTMNGLFEAAADAAEEAIYNAMFMAESMTGYKGRHVPALDLGDVRRIVEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V229</accession>
    <name>A0A7D5V229_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g087810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542334.1">
        <property type="nucleotide sequence ID" value="XM_014686848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V229"/>
    <dbReference type="GeneID" id="26244848"/>
    <dbReference type="KEGG" id="mbrn:26244848"/>
    <dbReference type="OrthoDB" id="3890746at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI72073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="221" mass="23704" checksum="946F29FC2F9D26B8" modified="2021-02-10" version="1">MSSSLKNELSSSDFEVDSSEIQSHSRVQKVKLIHSLRTGLTGLALAAGIAILGLSADTLSVYNATHLPADFLLSLWPESLDIRPTTSLVAGSAIVTAMNVVSLVASKNEFVRGRIMAHSAVSLTAPVVAFIASLVAMVFFYAINASTTVVSFQSWTCRWKSVPMSTRPYFGTLCRESQTSLALAVLLVPLELLILVTACFQAVMEKKVEVILHLRDGSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2H9</accession>
    <name>A0A7D5V2H9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g097630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546578.1">
        <property type="nucleotide sequence ID" value="XM_014691092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2H9"/>
    <dbReference type="GeneID" id="26241001"/>
    <dbReference type="KEGG" id="mbrn:26241001"/>
    <dbReference type="OrthoDB" id="10298989at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="235" mass="25676" checksum="F742267563D639E8" modified="2021-02-10" version="1">MHCAVNGIGQVAITSVIAVIAAAKEPYDTHRIEQLELASQDDARRLGVPGITASIQPVHSGPVILKGHSQLISSQHGERAFFLYRGLLDGNACVAVETNSPMAKHQAFPNFYNPTTRTSACTRCIAERAQNLSSVLCRKGLGRCLSQTLDITYMALDPCFNLRIHRCIYLGKSHIMFDNIKPVLREYFTLNLVAHHDTGPQIEYSSRVLISNAVAVAIGRGGVGPEEEHEAFRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2S6</accession>
    <name>A0A7D5V2S6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cleavage stimulation factor subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cstf2</name>
        <name evidence="6" type="ORF">G6M90_00g102860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546062.1">
        <property type="nucleotide sequence ID" value="XM_014690576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2S6"/>
    <dbReference type="GeneID" id="26240485"/>
    <dbReference type="KEGG" id="mbrn:26240485"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI73370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="339" mass="35613" checksum="20D0D9D2BD6716E9" modified="2021-02-10" version="1">MSTRPPSRVVFVGNIPYGLSEEQITEIFSRAGKVERFRLVYDSETGRPKGFGFADYPDTGSSSNPYAATEHTAIASSTLPRNHADLISATDSASSAVRNLNDFEVMGRKLRVDFSNEQKSGDDDNSQSTSNPTNGTPTNAYGAQAISLPPLPAGKEIPPGLTCTDAISRTLNTLPPSQLLDILGQMKTLATSEPQRATELLQQAPQLSYAVFQALLLMGLVSPEAIQSVADPTAPLPAPQQPATAYPGSAAVSAYSTANNNTPPVAGMPYAPPAAAAPTTAQPSYGAPAAPPPASATAQDPDALMRAVMDLTQAQIDMLPEADKQQIMALRASFAGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V2V5</accession>
    <name>A0A7D5V2V5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kti12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kti12</name>
        <name evidence="5" type="ORF">G6M90_00g086900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542427.2">
        <property type="nucleotide sequence ID" value="XM_014686941.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V2V5"/>
    <dbReference type="GeneID" id="26244941"/>
    <dbReference type="KEGG" id="mbrn:26244941"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002734">
        <property type="entry name" value="Chromatin associated protein KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="328" mass="37100" checksum="FA8201F99BC7447D" modified="2021-02-10" version="1">MPLIIVSGLPTSGKTTRAKQLHDYLSARIAETQPPKYRLHLISDDSLSISRAVYDLSPDTVRLHARSANSSEKDARAALYGAVKRVLSERDIVILDGLNYIKGWRYQLHCEAKAMRTPNCILRVACPVDQARQVNEERRRRRQDTTEHHGESVPEAYEPANWDNLVFRYEEPNPMTRWDSPLFAVLWDDDEAQTKRTFDDLWDAMAGEGRKVVKPNQSTVQRGREAGGDYLYVLERETQDIVKRILEQQGDDGGGEVKVPLAAADREDLIVDLPAGKKVGLPQLQRLRRAFVGLNRGGIGLERVGNMAADGMRELFVSYLNDAFEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V309</accession>
    <name>A0A7D5V309_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Pm20d2_1</name>
        <name evidence="3" type="ORF">G6M90_00g082520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543481.1">
        <property type="nucleotide sequence ID" value="XM_014687995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V309"/>
    <dbReference type="GeneID" id="26243658"/>
    <dbReference type="KEGG" id="mbrn:26243658"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03887">
        <property type="entry name" value="M20_Acy1L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF4">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="432" mass="46468" checksum="73734C076FCF7F46" modified="2021-02-10" version="1">MEDGFVLVPRPGDEVGWSETTCEYLPDIDHFIRGLEPSLWSLNSFLHDNPELAYKEYKAHDALASFMQSQEGWRVTRSAYGLETAWVAAYDSGRPGPVVSFNAEMDALPNLGHACGHNLIAMVSLAAGLATASMLRRHHLPGKVIIIGTPAEEGGAGGKIKCLEAGAYADVDVSLISHPGILNNSPMVRTTAFTHLNVAYYGRASHAANSPWLGINALDALIVAYNAISVLRQQTRPDDVIGLQITNGGNKPNVIHEHAAGVAVLRAASASRLQELQRKVEACFRAGAEATGARVEMEVVPGYKDHFPNRVLAASYRKYWEAMPDMPDPPLPPRGQFTWVKASTDQGNLSYALPSMNVSFAIPPGARAGPPHTPDFEKASGTRGAFARAMRVAKAMAGTATDVCATPGLLEEIREQWRHDVGELNGSGRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3B5</accession>
    <name>A0A7D5V3B5_9HYPO</name>
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        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
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        <name evidence="12" type="primary">RPS4</name>
        <name evidence="12" type="ORF">G6M90_00g092080</name>
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        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
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        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="39"/>
        </location>
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        <location>
            <begin position="95"/>
            <end position="169"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Small ribosomal subunit protein eS4 C-terminal" evidence="11">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="261" mass="29577" checksum="1F0E41F28DE3BBE3" modified="2021-02-10" version="1">MARGIKKHQKRLSAPSHWLLDKLSGTYAPKPSAGPHKLRDCLPLIVFIRNRLKYALNYRETKAILMQRLVKVDGKVRTDMTYPAGFMDVISIEKTGENFRLVYDTKGRFTVHRIQAEEAEYKLGKVKRVQLGRGGIPFLVTHDARTIRYPDPLIKVNDTVKIDLATGKITDFIKFDTGAVAMVTGGRNMGRVGVITHRERHDGGFNIVHIKDAIDNSFATRESNVFVIGQDKPWISLPKGKGVKLTIAEERDRRRAYTQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3Q8</accession>
    <name>A0A7D5V3Q8_9HYPO</name>
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        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="26"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="192" mass="21506" checksum="247DE773B7DBB6D5" modified="2021-02-10" version="1">MLYPYSYDGNLDALSNHILCVALFNTTDSLKHTTPLPGDVNAAKGVEMLQGHVFFIQFNPHMIKYEAIDKPMDPEPQLPTDRGLHGVAAPKCYQVTDKVHALPAGLWDSDVVSTYEFINLEKGVFIRIRSPLNTIMETVWTIQEKKGGGGYELIEDVVVKCSRLLVGVIRNTCEGTWRGIHEKMVAEMQKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_066131514.1"/>
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    <dbReference type="KEGG" id="mbrn:90968159"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI73273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="40" mass="4237" checksum="54A4EC34F24044D1" modified="2021-02-10" version="1">MMDSVAVGSAGSGRSQKFLILKHLGGVGHKHWDSSLGRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V3V1</accession>
    <name>A0A7D5V3V1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g103610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545987.1">
        <property type="nucleotide sequence ID" value="XM_014690501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V3V1"/>
    <dbReference type="GeneID" id="26240410"/>
    <dbReference type="KEGG" id="mbrn:26240410"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI73894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="245" mass="26838" checksum="7BB47492ACC28677" modified="2021-02-10" version="1">MKEGNDESGVYTHTLSVPYIWFPALHWPRPWTSWAVRWRVFGAQLRPGGRKAKRRRPLPRTGIIEQPSEARTWASPEPRAQSPEQRREHVAAPPEHIVPSRVPATSWHLGGLATASFGRDSISSGSPLGRGRGETGDLGARGGLLSARLCGLVDMDCPCLVGVSGLYGDHIGDAARRGLHGQGWVVWKGGHMRRLWLWAQGHFGHALLLVAVLASFLPSLPSRWTRSLSQGAISHKSSQSPDDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V445</accession>
    <name>A0A7D5V445_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">gyg-1</name>
        <name evidence="15" type="ORF">G6M90_00g088950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987452.1">
        <property type="nucleotide sequence ID" value="XM_066131342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V445"/>
    <dbReference type="GeneID" id="26244735"/>
    <dbReference type="KEGG" id="mbrn:26244735"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="308"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="446"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="656"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QLI72352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="747" mass="81708" checksum="A88CDA1E42B1EF12" modified="2021-02-10" version="1">MSAADPATGEQLYATLLLSDSYLPGALVLAHSLRDAGTSKRLAVLVTLDSVSAEAITQLKTVYDYVLPVPRIRNEQPANLRLMNRSDLHSAFTKINLWKQTQFSRIVYIDADIVAYRAPDELFELPHAFSAAPDIGWPDLVNTGVMVLVPNMGDYYAMLAMADRGISFDGADQGLINMHFKHSLNRLSFTYNVTPSAHYQYVPAYRHFQSSISMVHFIGANKPWFSGRNASHGDTPFDEMVGRWWAVYDRHYRAQESAVQPSYRQTSGQRPSQGIVDSTLASAYPSTKLPSGSDEAKNTSQAYIEQRAGEYSPRQTSHDRSNIDASYSPQPIRPAHDEGGTATEMSTDSHGLVHVETPRDSAAQNQRQLPPLAMASWDAQRHPPPPGSKPEAIDFPSTHYEMSRDPAPFIPPVRYPSPPKNMWYEIPKEPPSPSTKIPRQIFPWEARQSAPSRSFTTPAADEPFGKPKAGESDEQYQEPTPAEAFDTLPGQFATGLSGSDVADRNTTASKVGAVSPAPAPGDPWSSYSRVNAWDDVPEISRYVDGLQRHRRTGSQTRGGTMATVLRPAVSGEALQIPKAFKVTDFPTELERPSLPVTPAPIRRPSRWESHNEPFNSAENAQFLPTAEGVPSQSEWDPAAQLQLLAQQQSEALLRKLSGDDGVPGKMASHEIPSRPLPFGSEPGQSPTYVTRSAPTSVLSPQPIRGKSPTAVLVADLTGRNDASPESTTKEGNSASFLGQKIDKTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V456</accession>
    <name>A0A7D5V456_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g108780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987887.1">
        <property type="nucleotide sequence ID" value="XM_066131760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V456"/>
    <dbReference type="GeneID" id="26243358"/>
    <dbReference type="KEGG" id="mbrn:26243358"/>
    <dbReference type="OrthoDB" id="4937733at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI74395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="213" mass="23876" checksum="5F002A331961FA99" modified="2021-02-10" version="1">MFSSSLRQRSEWSPALALFAQSPSRWRETNLLGHDLEFTVQYSASSSLTYRMVLISAKQVGTDDATRRIKQLPKHGTDKKAVVLLMQGHDAMSSFMRLQIQMLEHERISTIPVSSAGQFIDHLDALRRPSTIGMNGLAQIDRHAVQKDLLRHCVSGTPLSVQQVDVLLGSVRHLRELANMVQTREGQETICRLLGDADGRSLIEHFTNGPKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4B1</accession>
    <name>A0A7D5V4B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g089920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541651.1">
        <property type="nucleotide sequence ID" value="XM_014686165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4B1"/>
    <dbReference type="GeneID" id="26245514"/>
    <dbReference type="KEGG" id="mbrn:26245514"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028972178" description="Extracellular serine-rich protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI72472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="20129" checksum="B13D65498C4AAEF3" modified="2021-02-10" version="1">MLFTAVKVAAFSALAAQASAKTIRIDVGKDGLTFSPDSVTAANGDMLEYHFYKQHSVAMGDFANGCRPAAQGGFFSGVMRTSGNGENDQVFQVMVNNTNPMAFYCTVASHCQNGMVGVVNPSSTDSLDKYTSTAKSASTNQAPPAVFGGRMAQGSATSPSGASGTASGAQPTKSGAASHMQASLGGIGAAALGFAAFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4I0</accession>
    <name>A0A7D5V4I0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">arg4</name>
        <name evidence="24" type="ORF">G6M90_00g099170</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546430.1">
        <property type="nucleotide sequence ID" value="XM_014690944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4I0"/>
    <dbReference type="GeneID" id="26240853"/>
    <dbReference type="KEGG" id="mbrn:26240853"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="215"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="752"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1017"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QLI73119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1166" mass="128131" checksum="D792545E4D28882E" modified="2021-02-10" version="1">MPSMLAGRAPVMLRAGRRIPRTLPSPARSLTTASLRSSARSLLQAKQVPKRLGTISIVRNYSSSPAESAPNTKAYIDSGIIKHVQNVDVKKVLVIGSGGLAIGQAGEFDYSGSQALKALKEAGVASVLINPNIATIQTNHSLADEVYYLPVTPEYVSYVIEKEKPDGIFLSFGGQTALNLGVQMQRQGLFEKYGVKVLGTSVRTLEVSEDRDLFAKALEEINIPIAKSIAVGTVDEALDAAEKVGYPIIVRAAYALGGLGSGFANNEEELRNMAARSLTLSPQILVEKSLKGWKELEYEVVRDANNNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRSAAIKIVRHLGVVGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGHSLPELPNAVTKTTTANFEPSLDYIVTKMPRWDLSKFQHVKRDIGSAMKSVGEVMAIGRTFEESFQKAIRQVDPRFVGFQGDKFEDLDYELQNPTDRRWLAVGQAMLHENYSVEKVHELTKIDKWFLYKLQNIVDCTRELQAAGSLQALKKDQIIKAKKLGFSDRQIGMAVNATEDEVRACRLGFNIRPWVKKIDTLAAEFPADTNYLYTTYNGSSHDVTFEDNGTVILGSGVYRIGSSVEFDWCAVGATQALRQMGEKTVMINYNPETYSTDFDTADKLYFEELSYERVMDIYELENASGVVVSVGGQLPQNIALRLQETGGAKVLGTDPKDIDKAEDRQKFSEILDSIGVDQPAWKELTSVQAAEKFAEQVGYPVLVRPSYVLSGAAMTVIRSQEDLKEKLEAASNVSPDHPVVISKFIEGAQEIDVDAVASKGELIIHAVSEHVEQAGVHSGDATLVLPPANLDGAVMERVKDIAKKVAKAWNITGPFNMQIIKADDPEGGEPALKVIECNLRASRSFPFVSKVLGLNFIDVATKALVGKDVPKPTDLMAVKRDYVATKVPQFSWTRLAGADPFLGVEMSSTGEIACFGKDLIEAYWASLQSTMNFRMPEPGEGLLFGGDTSKAWLTQVVDFVSPLGYKLYAASNDVKEFLESTTKDKINVEVIEFPKEDKRALREVFQKYDIRGCFNLAVARGKTTLDVDYVMRRNAVDFGVPLFMEPQTAILFAQCMSEKLPRKEGIPSEVRRWSDFIGGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4M7</accession>
    <name>A0A7D5V4M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g113180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014539785.2">
        <property type="nucleotide sequence ID" value="XM_014684299.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4M7"/>
    <dbReference type="GeneID" id="26247450"/>
    <dbReference type="KEGG" id="mbrn:26247450"/>
    <dbReference type="OrthoDB" id="4935235at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF3">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="95523" checksum="D6819EE4A4BE2537" modified="2021-02-10" version="1">MPRDTKSSLRFARPSVRQFNKDAAKAAVQKYQEKPLSEVCRLDPKTRQRRERIWQNWEEFAACAEVDPVDIWFDLCLGNPEVQAIFQGFLRQYWEQSVTLRPCLGPEEYEEVHTINCASTIEDVWCLLVNHADDRIMKPKRLQDRENAGIWSLKYSSRRTSSTCGPTYEIARWIPEFGTEVGLNLGQTFQKDGATTDDILTILSTLWNRANDVRCSPDDRLSFTMYVVEMGLGGWRPGALELKKYNHVKLAWVRDPVNPSVTRTICWSTVDHNKLRRLRIEREQRSSLSYALSVVPTLVLCLTTMFTIRAIRDNAFEAGFTSCDEVLHPETLEEGVNFVELRWKEEFMSDDKYIMPMNYHKFINLWNEVRMVLGSRSSLRPYSVRVGAVGRLDGCLQPALRNFIVSHSTEVFERSYQPVRLRANLANIAFGDKARHDTALWEAISNSLHNRDPNAPTRLTKKEIDQFESRKDITELRKELKYITAKEGSSSQEAKKVSSRIRYTLDCLERLEIQEKRRKYFEEADKLRAMNKSTAHLKQEVQNLKRKRFGNSSAYAAKLASLLFQTNITSALADRLVAFISGASVLNKIGDVLHFRNESKEPARCLFGCGTFFNTSALTRHVRHLHMHIFKARFLCPECKRMNLGDVVIEANPCAWSSHVRRVHGAVHTPNLESLPDVLCLLCDQQYKQRGFSRHLNTHSELFDEPISCPACLQEGRKVEVEGMGGWITHVADVHGGDRVLGAIEVYKTSFSDAETAPIDINPAEAQHRKELARRRQVDRKRKAGNAVPSGPLPYKRAKTDLSQPYAHASGDSDWEISSPDPHADEEFWVDGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V4Y3</accession>
    <name>A0A7D5V4Y3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g110580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543801.1">
        <property type="nucleotide sequence ID" value="XM_014688315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V4Y3"/>
    <dbReference type="GeneID" id="26243188"/>
    <dbReference type="KEGG" id="mbrn:26243188"/>
    <dbReference type="OrthoDB" id="4892971at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11263" checksum="62B38855C3D224E4" modified="2021-02-10" version="1">MASITILYPSGHDFDIKYYMQTHMPLVSASWKGEGLKSWEITQFAPDQIYQIQAILKFESLAAWEAASTGKNSEAVFGDIAKFTTAKPVVVKGTHHGSENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V530</accession>
    <name>A0A7D5V530_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g103440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546004.2">
        <property type="nucleotide sequence ID" value="XM_014690518.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V530"/>
    <dbReference type="GeneID" id="26240427"/>
    <dbReference type="KEGG" id="mbrn:26240427"/>
    <dbReference type="OrthoDB" id="4156126at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI73831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="913" mass="101060" checksum="D1AB2CB74F9320D7" modified="2021-02-10" version="1">MLKTTTETGDISVFSIQPSVTPAAYHQHPRARPDMLEGITPPKYTPRKGENFYYADDHRHFRSYRDTTSEIISLYGYDNQAFYMTPGSPMFDDISHRSYSITTNSSRQLPSQKSSGTLQSQSSRSGLQRPRSPFPYPTRLKRPGVRPASPALAENGCIDYSRMIELDRVSQRTVHGSYKSTYNNWARRPPPLSLRPDFNRSTASLPSRASPGPYYSGPVSHRARTPGSSQSGASRYGRFERHARMPVDRCGRSPSLTSIVDMYRRPSTAKGSRQPPQLAGSFYYDYSEDFDRPTASHHDIKSQISIESPHIQDGGGRNYDEFAVKPKPDGPDHQDAAVDTLTPHSRSSLEYSTGNQEELKSGPKLEEETTRSSDADDTDLSNLIAARRLSQSAPADPEASKSAESLLQSDEHNMSVNMARLSKSGQSLRAVEAKPNSECHPNTLGTQQGSRVARCALDPTLPDFASIFSSFDLLGKSPCFKTADISAQKLSDESDTDSVASSNHKLGNQRHRRNVAAVRINTAELNDKSGHIEDGPVHEQELDILSPEPISPARGLKVKNSIPQLMKALPPLPPGMPSEGSHNQHPLRKWDGQLDEQPLCDCSRLHDMVREDDEIHLAEPVPTGLKQPPQSGKHSSPSKFKVRIKPSYSPVSGMGNINCAHIKGDMQGVSQQSTAQAKPKLKLKLSRSQLGQGRQATGEPFTRVNRLKQCNSLADLALYSSSGTKAGQRFANEDNARGNAQSEGCVQSTFETRHSQSSTGYKSPQPSDPFSIPYPPSSEDNTDKKGSLSSSNKDTLVQRPSCSSGRSPVQENGLRKKMSMFRLRIAESFTAKPPKKCKKIPELEQSDSHISVNMTLKGSETNLNTIDNRTQPPNSNIKSDWVTDRVKRWAIDARRALRSYVRRTLDRSSRWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V5A6</accession>
    <name>A0A7D5V5A6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoporin POM34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">POM34</name>
        <name evidence="3" type="ORF">G6M90_00g108300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544015.2">
        <property type="nucleotide sequence ID" value="XM_014688529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V5A6"/>
    <dbReference type="GeneID" id="26243402"/>
    <dbReference type="KEGG" id="mbrn:26243402"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI74213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="259" mass="27813" checksum="2F9551542D4D3D73" modified="2021-02-10" version="1">MSTPVQSTPTKAAPAVDSPGTWRHPRLNEITRRQSATNFSEKNIRQIVYNIVALLVLWSLRLLAKMKINPQIVSSTFRTYLSWAWFVFQIIPFIQICLACLPLVRAKDDLSDIPLTGAQRKLLGLPPTSAPPTPDAKFSTPPRYSRTPSIAGSVGSRGSYASSPLSGRGSPLIQGSFGASGSQYSPVGSPVFQKSISGLGNGRRSSFGSGSPFAQSTSANLFSDPGSPSPSGGKRTSVGLNSKWLYERGRRSSSSAWLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5V7C4</accession>
    <name>A0A7D5V7C4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987998.1">
        <property type="nucleotide sequence ID" value="XM_066131907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5V7C4"/>
    <dbReference type="GeneID" id="90968298"/>
    <dbReference type="KEGG" id="mbrn:90968298"/>
    <dbReference type="OrthoDB" id="4777024at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="65" mass="7366" checksum="01C25B5D5B006111" modified="2021-02-10" version="1">MDGNNSVLSVEEQFPTDTYENPTEVDWERPIADTGTERLPRVELIYGDPDHPRPEVGHEPKSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YKI4</accession>
    <name>A0A7D5YKI4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein BNI4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BNI4</name>
        <name evidence="2" type="ORF">G6M90_00g015500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548978.1">
        <property type="nucleotide sequence ID" value="XM_014693492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YKI4"/>
    <dbReference type="GeneID" id="26238422"/>
    <dbReference type="KEGG" id="mbrn:26238422"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="751" mass="80234" checksum="008BF98B8BEFCADD" modified="2021-02-10" version="1">MAALVQTYPQQTSTATMLQTRPSSTGGMITTNQPHGNHPYNMGGSQAPRSAYSSNGSTGYRNGSVSRQPFAFSSTPNLGQTLSWQQYGTYRTTPSGAVPSSPSHDSGVNYRPAMQSSPSANSMGHSNSFGLGYGGSRDDSALTPGRVTAPTARPQSYFSVSTQPSFSSSTKQSGPDRYRRTSTVQPSHHSRSQSTTLSPSPSMVSPGQAYQANRRYSASNMSANQGLVSVSSIDDLQQYKKSGQDDAMRMRRRSVHTIDTREFSNTRPISRDSADGKQARLLQTNSHSRNGSSESVASTRSSHSRRSSATNHNVSTPTSNPSLSGSDETAKSEQQKMLSVPPRGSSSDVVKRTHSPSPLSKPATMANEATEDTGSASGAATNFESPAAKQLAALNQKGGKTKSKTSRLRRAFSFGSAAEFRKAAEEAEKAEPSKLHKEPTAEEAYDAEQARIAQAQEAGGIGNSIYGGRFFGSTDNLSISSTASSASIMIRKMGRGMKKSTRSLVGLFRPKSVIGVPAAEPLAPEASQATVSMITVEAEAQRVNVTADPHAANGGTGFPRLERNSIDAAHVPEIGDERLGSSAGEQRKSIVGGDKERAEVLAAVRKGILKRPGSPSVRVTDGCPSPDLVLPNIPAIADSPISSAPSTPNDETLGHKRAGSIAIGSEDYFMSALRLRQDSQSGTPPAKRNATFSPRIIFYDTWPSQEYDRRGEIATCNRLTPLLAQQIKEELNSFKMEMEVHENSKIYTHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YLN3</accession>
    <name>A0A7D5YLN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">cprA_0</name>
        <name evidence="20" type="synonym">cprA</name>
        <name evidence="24" type="ORF">G6M90_00g022190</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548335.1">
        <property type="nucleotide sequence ID" value="XM_014692849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YLN3"/>
    <dbReference type="GeneID" id="26237779"/>
    <dbReference type="KEGG" id="mbrn:26237779"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000001">
        <property type="entry name" value="NADPH--cytochrome P450 reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
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                <person name="Kortsinoglou A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">4556</strain>
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    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="101"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI67960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="517" mass="59330" checksum="46D0BDA25853E688" modified="2021-02-10" version="1">MTEYLLSRLHNGASRARSFLNPPLDRFDQSDELSQGLLSNSDGYELGEHQTRRKSCIKIAHSFSFLSVFALLRLLVVAITPSFISNIYYASKPRQLHKTSFLDGLRGYASFIVAVYHLLGIQPNNEWIEETWGVNEQEGMGSNLLQLPFIRVLFLGVPMVTCFFLISGFVLSYRSVLLIRSGEHERLSESLVSLIFRRGFRLFLPTIASIIFEKILVPCIYRSPPPVWTMISDVYAQTSAAMYCWGWDNHNVSLLHLWTIPIEFCCSMLLFLVIIGVSRLRTWMRLFVVGLLIIHSNASGHWAVFLFMAGLFIAETEAIIEQRKRSQKGNESIGEGMQWISRLQSAFWITIFLVGLYLAGYPIHRVESSFDFRWVYPHTPKVYVDTEGFFLPLKFWTSVSSVLVIVALFRVPTLQKAFTTPVAQYLGDVSYSVYLVHNAIQISIGADIKARVHSWFGEDNSQWKRTAILVLDIVFIMGIVIWVADIFWRFVDKPIVRFTRYLDKLCRKPSIEVTLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YS57</accession>
    <name>A0A7D5YS57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g065790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540194.2">
        <property type="nucleotide sequence ID" value="XM_014684708.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YS57"/>
    <dbReference type="GeneID" id="26247003"/>
    <dbReference type="KEGG" id="mbrn:26247003"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46893" checksum="7F9D84F843460AF8" modified="2021-02-10" version="1">MSISALLSVPNDCGLPPILLVAALIVLTGIAIRRTSQQRIDVGRPLRLITKAQGESPQSATSPICYRVQSPQPYHGWSIRHTKPLPYRAFRYGPKYNITMGLRTIDRDEWIELDNHFPKYHADKAIRIQERGDKCIKTHPDAVPAAMELLEELANYLPARYPGLFKRTAVGIDNVWSGESFNILQRPLREDPMTVCARLIQDDLALLLEQPDGTYRLLAGCILLAGFWRLSDKFGMSLSDIHTSGNVPSFQEKLERGMVKFFQRIKTDTMYGRSNYFIQVDDSLPWSHSIGDEDDPDVGWSTAEQGKIIHHHWFRSERQSLRRLPRTRAICFTIRTYFLPITEMAEEDYVPGRLSSAIRSWDHDVSKYKGRAKYEAVLLDYLDRKHQDQVRNGLDLAREEHVRQYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YSZ4</accession>
    <name>A0A7D5YSZ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase FUM15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FUM15_1</name>
        <name evidence="7" type="ORF">G6M90_00g003350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541993.1">
        <property type="nucleotide sequence ID" value="XM_014686507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YSZ4"/>
    <dbReference type="GeneID" id="26245024"/>
    <dbReference type="KEGG" id="mbrn:26245024"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="549" mass="61276" checksum="5213BA7AF9BA1C6C" modified="2021-02-10" version="1">MTGIRHIPLKYMVGISLVGCAVPKLLHLYERNGQALQVFFALYFGQISLFLFYAVLIYPFFLSPIRNLPRVKGGLPLVGHGIELRKYGPGYLAKKWIAENPNNGMLRVLWHGNQEMVIVNSPQALSEILVTKCYSFEKPKFARRFLAFIIGWGLLTVEGDEHKKQRRDMLPAFSFRHIKDLYPLFWLKSKEAVKAMTTECDEKGLAEMEISSWTARCALDIIGLAGVGVDFGSIKDPNSPLAKSYEFLQPSPADMPLIGLTAFLPDLIMHNLPLGRVRNANKASKHIRAVSRDLIRKKRGLLANKEDAGLDILTVALRSQLFSEDTLVDQMMTFLSAGHETTASSLIWATYFMAKYPDMQERLRKEIREHLPSADSDTDITSADIDNLPYLNAVCSEVLRIHSPVAQTVRVSTGDTTVQDQFIPRDTLLVLVPWATNTDPTLWGPDAYEFKPERWLSPEQGGTSATNAASGGATSNYAFMTFLHGPHSCIGGSFAKSELACLVAAWIGRFSFELKDKSLLDERNIKIDPSVVAKPKGGMHMLVRVVEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT78</accession>
    <name>A0A7D5YT78_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-saccharopine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fap2_0</name>
        <name evidence="7" type="ORF">G6M90_00g039220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547277.1">
        <property type="nucleotide sequence ID" value="XM_014691791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT78"/>
    <dbReference type="GeneID" id="26239840"/>
    <dbReference type="KEGG" id="mbrn:26239840"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="427" mass="46875" checksum="559A99ED7EBDB7F7" modified="2021-02-10" version="1">MTSYLIIGAGNFGAATALTLAKREGTTHVTLVDTTNFPNPRAASHDINKIVRDDYPDKLYMQMLKKAMPMWRNHGLYKPWYHEVGMLRADPSNFGEQSIASYKEMGIESKAHFLTVKEVRQRWNGSFATANFDGLDKILFNPAVGFAEADKALGAVVQEAVDQGVEYVVGVVTKINIGATGECTGVTLQSGETLHADKILLATGARTAALLAQSAPENQQLQVGDRLLATGAVSFYAKVQGAQQEKLSSIPVLKNCLPQVKGEGMSILADGTIKFNCDMCFTNYVECPLTGQRLSMAPEDSAFNVWTGPKFIKFFQERARKTLDGLYGKEVEDVAIDAYRMCWDASTPTHDFLITPHPHSHGLYVATGGSFHGWKFLPVIGDYIADMMQGSLETEFADRWAWDKKGGDGHSANPTYQIVGDLQDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YT88</accession>
    <name>A0A7D5YT88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">G6M90_00g074390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987131.1">
        <property type="nucleotide sequence ID" value="XM_066130999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YT88"/>
    <dbReference type="GeneID" id="26241660"/>
    <dbReference type="KEGG" id="mbrn:26241660"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="245" mass="27514" checksum="7E7FF5B561691BEF" modified="2021-02-10" version="1">MPGFNILMKNATTVHTSFMDHQSASQSSAELVPQTTATASPLIPIPWLDFLGTMQTLPESQASSMAEPHGPVAYPYLDALHQEFPHNTEFINDTPFVYASPTSTASEPSVPHLSQDTQARPPRRRENRYRNAPPSVQSRRRAQNRASQRAYRERKEQRIRDLEHLLQEAHRREETLTQAYLSLRTEYERLGGEQEDRSSMGTPTPVNGETMPARLGAASVQHCSDVAGGFDFSPNAYEYADDTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTD2</accession>
    <name>A0A7D5YTD2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spindle pole body protein pcp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g042930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547627.1">
        <property type="nucleotide sequence ID" value="XM_014692141.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26240190"/>
    <dbReference type="KEGG" id="mbrn:26240190"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="179"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="936"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="795"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="954"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1286" mass="147603" checksum="670C382A433F5859" modified="2021-02-10" version="1">MAQPGFGGALDTPRTNVGDATYLSRQPDFADISQEASFHSPGKDGDFFQQLRNGRSNGVSLRTPRQRGPLADRRNLPQNLGEVEFTPMLKFSARRNARKNGKENGTTALNAPALDRIDEDDMTPIPRMDSSVYLGSRSQSFLDNTLPQLEGSSVASTPLAMQPRRGGDKGPLQDGNQLSLREQENVIDRIEKENFGLKLKIHFLEEALRKAGPGFSEAALKENTELKVDKVTMQRELHRYKKHVTAAERDLESYRQQMQELQEKGRRKQNDDGQRLELEQLRKALEERKSDIDALQQQVDQSHNDEDQLEKLRDNIEDLEADLREKDRLITERDDELDDLRDRLDAAEDKQREAQRRMSEMEGAENQNEELEEARETIQDLELTIRRLEEQVEDFKEKADQAMSQKDRAESDLEELQEEMANKSVMTKGLSRQVEEKVSRLQEELDKSGKEYADLEKELAGANEENEQLRAEVDELRNEQQEIRRGQHDDSAKVRGLEAELLAVADEKDLLQVRHETLKVESDALQRNVQQLEKEVEELQKNVSDEREYAVEIEKDLRQQYQDELERLNDAVSDLQAEVRERDNLYDNDSEKWENEKQALVSERERAEEKAAGLQRTIERLREAEGNLSNKESTLQKAMESEMERHKSEEAVMARQIDDLQDALETRQTLLTNLRNELSTVRDALRQTQIDYQGQVNKIVALENEVEVLRSKSNNQLTPGRRDAFVRDSQYLQDQVTRLKAELGSVQSSLAETRAQRDELQRQLHQNGAQENDTLQVDQERLDLRAAKMKLVSEVRLLKDENKALSEGRKEAEKALEHEIVKVATLEDRLKQEVQQLQTKTKSSTATPFNDQETVSARRTIRELEQRVKDYEDQLVKLQAADDGDDVGNISILRRDLSASRQKELDFLQKEAVHRDTIRGLNVQIAELERQLHESKVSQMAASPSSSAANSQRTLDELKSQAAESERMASQAIGELQKQMSDLEDQKLVLEEVLEEANQQAEEAAAQNEKAMRRIRHKLDKAERERDAAIASHSENNKQGKHLKRSQAEIENLEHDVRQQQELIDGLAAAEVSLRRKLERARSERAAFRMSAEKLQRDIQLLQVTNGPISGQEDGRAVAKRHDGTLDGDNHAFETLVRAAEGAEERHRKELKGMVMQMEWMQARWEREASLRSDAAYAKKFIQLQLDVANACNKAQLRELEHIRTNLLHSKKPLALPAAPNGLAFGKVKPTSIRPFLTMARFIARMRIASRNWSQQEQVRLKLVAARDDQRRVKRSRLFKVVRMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YTZ6</accession>
    <name>A0A7D5YTZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g091000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI71800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541754.1">
        <property type="nucleotide sequence ID" value="XM_014686268.1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        <location>
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        <location>
            <begin position="1"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="QLI71800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49490" checksum="8DF982117F604AF5" modified="2021-02-10" version="1">MGFLSLTYTRPQHVEQQSLQRSRESLSDEKTDGSVKSGRSGHSAGIPDSLSFDNVMNGGTCPPMTIRDFMNYLVYVEHSAENLQFYLWYKDYVKRFHEANAPDISLAPAWTQTMEDEAVAKIRKEHATKTCSPPGAASIFRGTDFEKKVPEMPENALNPFNSPPQSSNGGSNKGSIDAASRTMPIAISGSYNSQAADAFQSAGARLPFTIQPFREEINRVIATYIMNGAPRQLNLASWEQKAAVQALSHTTHPTALRGIFGTVDSSLRQQAHPNFVRWSICNGNPARVLYARFLGVFLIVAGFAIAIPITLSKLNRGYRAVAAIAWILGISTLVAAHKGLCVVLHGMHHRHVRPWELFMQDDGEKPNKRSFDSFGTQNSYEDEPWVVKYKKRNVVRKVFDREVWIQEPALRQIQDTIFVQALLASVLLSVVLAAIFVAVPQGHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVA0</accession>
    <name>A0A7D5YVA0_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">ATP synthase F0</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">G6M90_00g025040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548076.1">
        <property type="nucleotide sequence ID" value="XM_014692590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVA0"/>
    <dbReference type="GeneID" id="26237520"/>
    <dbReference type="KEGG" id="mbrn:26237520"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33476" checksum="B4BCCEF60B624979" modified="2021-02-10" version="1">MANWNTWNPFGRRESHSSGSILTYKLLTLLTWLLSVIVTIYYAIHEPKDGFTLRRRIWDQNNLIRTAFTMSPVLGDIYWVILFILQFGYITHLFSRTPETVNYAASVGSHFIVNNLFHFAFIMLFVRSHFIWAEVMLVINFFNLSSLYFRHNTSPRFIHTPVVSGPLAWTFVALYWNGAMMVYHPHNLVARIFGNIFIWAILAYGGFFIVAYKDYTMGFWLSLLAAAIGVAQFERQIIALQWIFAFVIMAVLFLATVTVAVPAWTGRDYLWRREAQPAGEAERAPLLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YVB5</accession>
    <name>A0A7D5YVB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g038140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547173.1">
        <property type="nucleotide sequence ID" value="XM_014691687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YVB5"/>
    <dbReference type="GeneID" id="26239736"/>
    <dbReference type="KEGG" id="mbrn:26239736"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI66884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="766" mass="84909" checksum="65F59BF35D4F5DE7" modified="2021-02-10" version="1">MAPTAEKDGHKAKDDSTHVKELYPMVNWKYDLFLYMMGNLVDLFFREVVPRGSWKVPQSGPVLFVAAPHANQFVDGLVLLRTLRQEAGRRVSLLIAQKSVHGFIGWASRQAGAVPVGRAQDATKSVPGTIYLPDPVNDPTLVRGVGTNFGTGDGQIHGMVFLPPGKKTASVSSDIAQILGPEEIRLKRPFKGKLAMQQLTGRDDIDEDGKFTNKSIKGPAPGYEGTKFKAAPNIDQTKVYEAVFSRLRHGGCVGIFPEGGSHDRTELLPLKAGVAIMALGTLAEAPNCGLKIVPVGMNYFHAHKFRSRAVVEFGTPFEIPPHLVELYRNNQRREAIGQVIDTVYQSLSAVTVSAPDYDTLMVIQAARRLYNPTGKKLPLPVVVELNRRLAMGYERYKNDERITSLSASVKNYNLQLRYLSLKDHQVQYARMSILKVLFLLVYRSIKLLLLFFCTVPGLLLFAPVFVATKIISIQKANTALAGSTVKVRGRDVMATWKILVAMGLAPTLYHFYSIIIVFKVWQDRLWGYVPMWVPLWLAYIGIWPAMIGLTFAALRFGEVGMDIFKSLRPLILCLVPSSDFNIHTLRLRRAELSAQVTDLINTLGPEMFSDFDKTRLVPDVSRLESGGATPERAHKRKDSDQSNTSADVETPPMLSRRSTTQSSRALPRNDSFSNIGTVGIFSTRPPSRSRSRSRSSSAGGGFGSGGFPISGFTTLDSAEGFNEATRKIREAMKNRRKKSDKLHAADDDDDEDSEEEGYDEARKKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYA1</accession>
    <name>A0A7D5YYA1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Respiratory supercomplex factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RCF1</name>
        <name evidence="13" type="ORF">G6M90_00g028510</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541313.1">
        <property type="nucleotide sequence ID" value="XM_014685827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYA1"/>
    <dbReference type="GeneID" id="26245948"/>
    <dbReference type="KEGG" id="mbrn:26245948"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="12">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI64127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="214" mass="23940" checksum="13B9C5B3CAE850B6" modified="2021-02-10" version="1">MGDRIPPPMPGHLPSSFDDNEEFFNERPMQKVVRKLKEEPLVPLGVGLTVFAFVNAYRALRRGDSRQANKMFRARVAAQGFTVIAMVAGSMYYSQDRQKTKELRKLKEERDAEEKRQKWIKELEARDEEEKMIKASIDKRRQKLEAADTAANSGEEGAGTGGILGKMGLWSKGQEAAEAEQGAKEETKKIENPKSSLGAISEVLVKQKGDEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYB4</accession>
    <name>A0A7D5YYB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TIM11</name>
        <name evidence="12" type="ORF">G6M90_00g102280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI72841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546118.1">
        <property type="nucleotide sequence ID" value="XM_014690632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYB4"/>
    <dbReference type="GeneID" id="26240541"/>
    <dbReference type="KEGG" id="mbrn:26240541"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI72841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="94" mass="10453" checksum="8BF9EBFC963CCCDE" modified="2021-02-10" version="1">MASTGVNVLRWSALAVGVFYGFSHQRTITTTQRAEHAKHEWESKQKLIDQAKAEYAKKNNPAPAAASKNDVVTDVNDPKFDLEKLLLKVSQESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YYV7</accession>
    <name>A0A7D5YYV7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g055670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544161.1">
        <property type="nucleotide sequence ID" value="XM_014688675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YYV7"/>
    <dbReference type="GeneID" id="26242573"/>
    <dbReference type="KEGG" id="mbrn:26242573"/>
    <dbReference type="OrthoDB" id="4367324at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="415" mass="45893" checksum="B6580DD86B3E62A5" modified="2021-02-10" version="1">MAAPGDRNSTSLRAILTQAKPQISCMKYTASKNTIGRWPLPKHHGIAEWSEFNLESLVESYGHILNREGPGGIPAADLPNNKIEISRVNHIRLLIEWNSRVIDMAQKFTKESLGIDTGVSLLNDVTTRDGSARARIRTAPAKGAPTVDHVIALDDHPLTNLVVGLVKSHSRFPASVVVDDSHLTTTDQMWALGQLANLCHTAKTRYGYIMTDHALVACRCTIFEDPTYRFGRFKVALVPVPWSKRGPEQLTTDLALWWLCMLAASAPHNRSTLEHEMVPINKWEVKYYDDGRGWVRRHKYSGYEEPTEAPSPPPYETPAPDDVAGNAALFMAAVGGLNVQEDFDPNPPPIPGQPADLAQSYQHNPTDVVVAYDGQGLSFDAANEGLLNFDVANEGQDYFFNFDAANEGEDFDFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5YZU8</accession>
    <name>A0A7D5YZU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERG7_0</name>
        <name evidence="11" type="ORF">G6M90_00g063240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542559.1">
        <property type="nucleotide sequence ID" value="XM_014687073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5YZU8"/>
    <dbReference type="GeneID" id="26244508"/>
    <dbReference type="KEGG" id="mbrn:26244508"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="94"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="404"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="745" mass="85135" checksum="2A6A65DB4B558F62" modified="2021-02-10" version="1">MATASGRDIGSAKSRKRTSDSELGFPEKPKIEAKTDPTRWRIKDDDSRHTWHYLTTKKAAEEWPQSYAEKYYLGLPLDLPALPKPETPLDSAKNALEFFQKLQLPSGHWGCEYGGPMFLLAGIVVAWYVTKTPIPSAYATAIKDYLAARAHPEDGGWGLHIEGESTVFGITLNYTVLRLVGVDPEDPLMVKARGTLHKLGGAVNSPHWGKFWLATLGVVSWDIVNPVPPEIWLLPDWVPIAPWRWWIHIRMVFLPMGYIYSKRWSCEETDVIRGLKEELFTQPHAEINWAAHRNSIAPGDNYHPKSSLLNTMNWFIVNVWNPYLRPNFIKERAEQWVSQQVDMEDANTGYADLAPVNAPMNTIVCYIRDGPDAFSTKRHIERLDEYLWVKDEGMLCNGTNGVQCWDTAFLIQGVFEAGLQNDERWRPMLTGALEYLERQQIRENCVDQEKCYRQPRKGGWPFSNRDQGYGVSDCISEALKAIILLQKVGGFPAVLEDQRIFDAVDTLLLYQNDNGALSSYEARRAGEYMEMFNAAEVFGRIMIEYDYPECTTACVTALSLFSKHWPDYRSKEIKIFINRATNWIKTNQRVDGSWYGSWGICFTYATMFALESMASIGETYSNSKISRRGCDFLISKQREDGGWSESYKACETMEYHEHPMGSLVVQTAFALIGLLEADYPHIEPLKKGIKLLMERQQENGEWLQEAIEGVFNKSCMISYPNYKFTFTLKALGLFAKKYPDVKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z047</accession>
    <name>A0A7D5Z047_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g006690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_014694353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z047"/>
    <dbReference type="GeneID" id="26239283"/>
    <dbReference type="KEGG" id="mbrn:26239283"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI65126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="171" mass="19135" checksum="D990535F6038FF16" modified="2021-02-10" version="1">MTRDYAVDDRLSTRSRHPASRHEWLQHATSIAAVPGPRIHFQYQKAVRLPAPPNGPMGPMGLKAWPSEFCRPDDPCLLMGPCSWKNIVNAGQYAELGDVECRGASWLVVGVSHQHRLHRPHRPHRPHHLLHATTLLEWTRSLQRPDKLGAKQGTAHGAPSPRSALVVFTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0H3</accession>
    <name>A0A7D5Z0H3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extragenic suppressor of kinetochore protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ekc1</name>
        <name evidence="4" type="ORF">G6M90_00g010130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549504.1">
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    </dbReference>
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    <dbReference type="KEGG" id="mbrn:26238948"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="466"/>
            <end position="559"/>
        </location>
    </feature>
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        <location>
            <begin position="573"/>
            <end position="637"/>
        </location>
    </feature>
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        <location>
            <begin position="905"/>
            <end position="952"/>
        </location>
    </feature>
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        <location>
            <begin position="966"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
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        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112252" checksum="8C26236E89C44110" modified="2021-02-10" version="1">MFWRFGGYANISTIDTILDKPDFTLEELLDESDLIQELKQHNSKLIEYLREDSILEKLLEYVVAPRLEVFATPDDPADDESKGKSRLLPFSRPRASSRATDVTDNDEEEQEKRRNRYALVASEVLSSDTWSIYEALTENRDLIRKFWKFLERPAPLDPLQASYFTKVNESLFEKKTDDMMELLRSIPNVVAELLRHVECPMIMDLLLKIIALDRNEGGQGIVEWLFSKDIIPALLSCLNPKHSWVVQTAAGDFIKAIITISANASQNEQQCIGPNELTRQLVSEPCVEQLIGYMLGGGNPLTVGVGIVIEVIRKNNSDYDPDMGTESNQVPSSRDPIYLGYLLRLFARNVPKFMSLIMDGPAKKEGSESTFGEKLEPLGFDRFKTCELMAELLHCSNMGLLNEVGAQELISTRDAVRQRLRHEGRLGPLREDDQSADDLTMRMSHGAVHDEGRRFEVTNADDDGFEEVESSKEMSEDTSHEFVKAEDDITAAPPSSFIDKDEDDFVDEPLSSPRLSVGSDKINEQRFEDPDLVVAPLSPSKSKPAELAESAKFANPDSIQRTEFDSATREIDEHLTSTQQPTESSLSTSALPEPTPSGSSLNPSDLGDQHRGLSPHPEDTPAPLFSSASAPQSVALDQTAQKTEIIVHPPAASHPVHGMESSEQIADVDDPSAALGQQQLPQNINIPLEHVVGDFLKMQFVEHRVVPAILTFFFSYPWNNFLHNVVYDIVQQVFNGPMDRGYNPTLAVSLFEAADITTAIINGQQASDESQAKTKTRMGYMGHLTLIAEEVVKFTERHPPELLSEMVLDKVMSQEWINYVEGALAETRERDNAILGGVRPEVALGHRASIGGGNGLGGVGLSGLGGASATGSNALAEAGLNGGIEISEGSNNGIGPFAISAGTLMSGFGSSSDEEDDEGDVEEEDVNSEVSGDSFDDRSTGSPEVAANANTDSPVDVISISAEPFGAISGDSSVDIRPRLGSPVRFTSTRDYEEDEIMEDGSPQDKWSGNHYDEHGTERSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z0P5</accession>
    <name>A0A7D5Z0P5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g005440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985994.1">
        <property type="nucleotide sequence ID" value="XM_066129592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z0P5"/>
    <dbReference type="GeneID" id="90967421"/>
    <dbReference type="KEGG" id="mbrn:90967421"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI65586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="97" mass="10432" checksum="D09C282A9D9D7F98" modified="2021-02-10" version="1">MKLAGSAFKAIRSAWTSTGFKYPACIPRGANTVYNQAVNVSADGTARDKADFANFAYQWALMLEGHHNGEEVKTGVPGLVNGNVAEHAEFHDGLVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z110</accession>
    <name>A0A7D5Z110_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g062520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986802.1">
        <property type="nucleotide sequence ID" value="XM_066130745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z110"/>
    <dbReference type="GeneID" id="26244576"/>
    <dbReference type="KEGG" id="mbrn:26244576"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="395"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="937" mass="106427" checksum="587984A376C5CA30" modified="2021-02-10" version="1">MRDKMETPSRPKGKKLPFKTTVLCKVASQNVETIHDEKLSAEDDGLDLFRRSKEMEPIIAAELQRSLKKRQRLEDERRQSAKSKRPLDDNIEREVIANAESGTFSQAARSTPPVVSELVKDSREVVSKFVTPLASKRMRLDSTLLRNASLDMDNADTTLNNLSSTRFLRSHPKQPTINNLPGDTLTSNGLPMVLLDSDDEDSIQVAPTPTNRRDSVCFIARDEDDEFAHYIRKAEEQRVHDGSYEAAAKEKIDILVTSIVPGTKPCCFKFLYDKQLRLVRNAWLTLQKHRGVLVDIEKDDDIVLTWCRKKAYAFSTLLNMGIRPHGDGRAIVDGHSTSGLAHGRTKVHIEAWTLDLFREMEREEALKRRRETVELLDEGGPVPAEREPVTPEVKIRVILKARDLDDVKMTVRPETTVGTLITSFRTQRSIGPDKYIGVWFDGDILEEHATMEEAEIDDMDTFELLHTFDALIGQSRNEIDEYLSRHPKLASNIRSLQSISAAEISNDIPTPPPENPQQENPPLDEVGATDRGACVKDNASLKTKIEALSGRSEYRKLRPRPSETPHPSVPGPVSHDDSCKPLRKKGDGNAEVGQEKTKRSCSQHSDGLKRDYILAKAAADVVANELTAPDTLIELREVILQERNRMSFNAQEPLSAFTKGKTASEGEIAEQLECLHTHFEKLRQNEHIKTIADRYHSALIVQLYDHYNKPKRTKYSLGVIFTKILLKDWVRKKLKNTTERTRRKKMQTKWKAEVQMHRIWLDFNDEFGCGALSLIPKQFRNTHGLRLNRPDEQELLLRIKAQHPYLKKDIEDLSFLMWHLLTYGVLPPQKLLLETLNELEIREMSQKNYRELLTFVDFPVPADVNGALEWPNRPHDNDFFSEDPAMLPQTAEQNAAEQQSAVAGSGSMRQFDDLMEECIDPAVLGPNAATPYDGAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z1F1</accession>
    <name>A0A7D5Z1F1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-galactosidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">G6M90_00g078050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545300.1">
        <property type="nucleotide sequence ID" value="XM_014689814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z1F1"/>
    <dbReference type="GeneID" id="26241333"/>
    <dbReference type="KEGG" id="mbrn:26241333"/>
    <dbReference type="OrthoDB" id="5071209at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30889" checksum="445C1942732EB263" modified="2021-02-10" version="1">MASRPPNLQLLQASVDPDDESEFRLLVNNSLVKYITIDAGIFSQDDMCFEPSLVSLLPPLPPGDWNQGRISRNPETGAPHFSAISNKNLPGITKTWHPTQIDHLEFHMGQKLRSNVYEATSPRFRSPVVTKFARFPWEVPLLEAETAAYQWIEGYQIGPDFLGHLTEQGRVIGFVMARIDDCRHATPEDYTLCYRALSKLHQLGIKHGDTNKHNFLIHKGKATLIDFDNASRAVSAQELETELGGLRNQLSDMSGRGGQVIETSFIECTDLDTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z233</accession>
    <name>A0A7D5Z233_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g070310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540646.1">
        <property type="nucleotide sequence ID" value="XM_014685160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z233"/>
    <dbReference type="GeneID" id="26246519"/>
    <dbReference type="KEGG" id="mbrn:26246519"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI70205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="555" mass="61692" checksum="322C5EF67AB56976" modified="2021-02-10" version="1">MGSNSNERLARIHELELLRQDALHKTESITRDEEARLLQLRLLTMRDENASLREKLGQKDFKISTLIRDSDQIRIDLDDSRQIIRAQEARLKKQDVDRASLKAEIEALNGTMQDSGKAMQEKFALTRELNRIKPELEHLQSQLTSFQATVAERNDLRRQLDSLEVELENEKRSKLRLQSRDDDAATTELKSRLEKAEQKLAAEKREREKMKREHERELASANAENERLEERISDLKEKSKALQSDLKGVKEQLEDAQSELVCDKPHVLPRGGEEKPRKAVALTADVGKKRRAAAEMNFESITIQTPGNDIVARERPTRKRGADKSTVGEKSAFSVTPFLNRNKSLTDESGQESSHDVSAEADPDPVPDEPADHGPPSESEDEEEPAPRPKVSFKSTVSFKSPAKPKKTRGRPPKAAPAPLAESTPAKTNRVMKTRGTPKVKSIPDISVEKSADNSTSTDQENVPIAASKKATSVLQSKAPEGEVKKKKRKLLGAANATLFDDDDGEAIAKPKPQPATSRRTRTVLGGGVRNAFAAGSSFSPLKRDRRGVNASFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2A4</accession>
    <name>A0A7D5Z2A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g027370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547850.2">
        <property type="nucleotide sequence ID" value="XM_014692364.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2A4"/>
    <dbReference type="GeneID" id="26237294"/>
    <dbReference type="KEGG" id="mbrn:26237294"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="269"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI64988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="630" mass="70508" checksum="30779AB1F2062736" modified="2021-02-10" version="1">MDSCIYVIDQPPQKRLKFTPPASPSPRLATQPPTGLPRDFSPQPDNNVGYLGATSFSAVFQDTQTVLPQSAQTPEQAEDLPFALFEEHPSSRSLSILRSIPDRATCSALFKLYVNPIDGWCRLAAQILNESLWITFGHVLEGTRTQDNLTTMARILCRNSSIPLREEHTDPIAWLRSFSGQKMRWESLGLLFCYWALGTKSLPENAELRETQQLRDTDRRRLLNKYTLGAGMCVDICKNGSTANSMLAILLYRYGIIQSIISGDASIQFWRIHGELAALTSFLGLHVTPPSMINDHSISSEMKRRLYSMIFKSDKVVATFTGRPPLIGSRFATTPLPLDVSDEELLNSDGNSLANSPNVDEHGWNNRGKIFSGTMMRAKMILTLIKEQILEIALQITPSGDTDQVLIDLRRRELEALDRFPKVLIYRDTDINDPDTDGPTLYSRVMIRLDHLQNMFFIERLLSKGSSMLGSEIIDISFEMISLTLIFWTHQEKLFGVSGDSEWLLMCYAAPAAGILCMELLRGRSSVATTPSRSSSTNPPITRSRLIQQLSLLVGFLDWVGPMAPNTESCSSVKKAVRHVLDQALNEGAPQVTAPMDWVGDFGVGFSGDMNDFFNFELLHTFDWLRPDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z2R2</accession>
    <name>A0A7D5Z2R2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g029070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541260.1">
        <property type="nucleotide sequence ID" value="XM_014685774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z2R2"/>
    <dbReference type="GeneID" id="26245895"/>
    <dbReference type="KEGG" id="mbrn:26245895"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF30">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="165"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI64889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="508" mass="55351" checksum="8FB804C8154413F1" modified="2021-02-10" version="1">MRLAPSRGFACLPVRRASTFPNTDSFSSTYALLATAVIRANHGHITASPKGSFALMTQQRRGIHSSERKSSTVAELPGAVPPPANLEPSRAPLSVLPLSMIIRSLATTVVSSSPLLLPPSLQIMTLLAHSTNPVFNPDRNPILRYFLKKSFYAQFCAGENPAEVQATINRLKNIGFTGVILGYAREVVLTEKQAEEVELAAGQETQKVIDNEIVPWAEGTLETVRLAQPGDFVALKFTGAGSLALHELKHKLPASPYLSKSIDSICQLAHERGVRLLFDAEQDALQDGIDDWTMEFANKYNTSPDTCTIYGTYQAYKKKTPAVLERHLAMAQEGQFSLGVKLVRGAYLGSDPRQCFFDTKADTDACYDGVAASVLTRQWNTTLEGNGEYPAAHLVLATHNAESVQKARAICDAGGAKSEIAFAQLQGMADEISCELVEASQSARAADASATPNLPAYKYLVWGTTGECMKYLLRRAQENKDAVQRTKSGRDAMWAEVVRRVKNTLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3R0</accession>
    <name>A0A7D5Z3R0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPC89 centrosome localisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g025660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548017.2">
        <property type="nucleotide sequence ID" value="XM_014692531.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3R0"/>
    <dbReference type="GeneID" id="26237461"/>
    <dbReference type="KEGG" id="mbrn:26237461"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="3">
        <location>
            <begin position="375"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="3">
        <location>
            <begin position="559"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="833" mass="94136" checksum="2E48918906A394C6" modified="2021-02-10" version="1">METDAIHRYRSRILREMNANRANPFNSPPSSTGSHGTVTMSSLFSDPDGESTRRLNEDIARVTAPRKLPVNWEAAHRKWPEYFSKPDTNKAPIFDDANDVRPWKPQSKENKPPVSNVKFAVDDSTQDIWPSTTKTRAEMQPRVDNESDISSILDKSPARPVSNYGATKSQKNPSPLSKPHTRAPSEPVGNEQRRSSITDAFNRLQRASLSPRNADQDSPNVSSAKSSLTAVPPSPASIASPSHNASNVRSFFMPDVSHLGDFVTGTLKFSGSMKNGVPIFVKHGKVHDRQERPSAAAHAQVDGIEVPKDEEKIFVSMDMIRDEIVSLQAAHDKVQEYAEGLQLQVERLEAQLRHGRFSGSGYDQSDKIMAQKKKLELEVATLQARLDSATRKISTNEIANDAVAHERDRAISRLQDACEDISKLTRKLSVRERELSTSREQLETSDHIRRDNDTLRRDLLSLKHNRDAMELDNASLRTDNENLRKEQKRLREEIDSLRAKKSNRNDSILAENRSLHTNNHRLAEENDDLRENLDAAQHELDVAREEIDTLRMAVETITQEKSALQGDNDSLVRHNEKYFNENKILRRENSGFERSVHDLHEQNLKMKEEVDFLKQQLDHCRPSHKNEISGRLDEETEENMTSAYFLPDITVKTNESHPSEPTATKDMPTLPEVTTQGYTSELETRDISQRTSNNRQPVKTSESHPAEPTATKDAPTLPEVITQGYTNEQETRDTSRRTSSNRQRSKSRPRASSKVVEFSIPEKSVIRNKNSGNTANRGSKRRHARAPSTTELDLTNEDVDITGDLQSEDFTNQDAAISLRVRVCLKGLMNRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z3U4</accession>
    <name>A0A7D5Z3U4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vma13</name>
        <name evidence="7" type="ORF">G6M90_00g098430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546501.1">
        <property type="nucleotide sequence ID" value="XM_014691015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z3U4"/>
    <dbReference type="GeneID" id="26240924"/>
    <dbReference type="KEGG" id="mbrn:26240924"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="358"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI73224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="479" mass="53848" checksum="89B62B4DA727A1B1" modified="2021-02-10" version="1">MSLDPPTYLASLQSNIRQRPIPWDGAVRAGTLTEEQYAKIRAVDKAKKLEQRKEVVEGDFDGYRLLFVGSPGKPSVLETAGKHANVIQYILVLLGDLIDAVPSLAKALFKNTDPYRHFLPLLHSNTTEDPIPLLTSHALTTLMSLSRDESKATEQALPVVFTYLSGLAKSTDAGLQDIAVQEYSALLFGRSSRHKFWNQRSETVEPLVKILQTAAGIGNGGNSAANLWSGNVNVRNNGFEGSLGGGVGLQLLYHVLLVIWQLSFEADEIGDDLNDEYDVILLYTHLLRLSQKEKTTRLILSTLYNLLEKNQTSLLPTAVLARLPALLENLGSRHMTDPDLLEDLQSLKELLDEYTKTKTTFDEYVAEVNSGHLRWSPPHRSQVFWAENARKILEFENGEIPRKLAEIMQKPWDNDKQVLAIACNDIGCLVKEVPEKRYQLEKVGLKTRVMELMQSDDENVRWESLRALGGWLKYSFEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z493</accession>
    <name>A0A7D5Z493_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g063170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542566.1">
        <property type="nucleotide sequence ID" value="XM_014687080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z493"/>
    <dbReference type="GeneID" id="26244515"/>
    <dbReference type="KEGG" id="mbrn:26244515"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF7">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="564" mass="62331" checksum="89565849B32EFF53" modified="2021-02-10" version="1">MAAADATATSKLASYFARLSPVPAFPEYTGPFKVGTVDVEIPVTDLHSPSPAPANAVDIPTVQFRVFYPAVPESSEKRITWLPNPQRHHVSAYTKFVGIGSTLADILSFLPRHLHYTTIPVHKNAEAADSETKRWPTMIFSHGLGGGRNSYSYIAGSLASHGVVVFCPEHRDGSAAVSFIRLADSSSRFFSSAARRIVPYNRIPHHVTPEVYEAREDQLRVRLWELGLLHDAMLAIDEGRGFTNMNLTTPTLKQFIGRLDVHEPGRIIFGGHSFGAATVHQFLKCNYYADVAEVANMKKPLFTPAKDSSIRKQITEKNVTMLLDMWCLPVLGPNSKPLYDLPLPVYADVPSAPGGTALLAVESEAFHKWTEHLHVKAKLLSPDPTSKTVTPPLFERPSGIKLPEPNFFYVVNSAHLSQSDFGILFPWLTKKIFDAEQPERALRLNLRAQLQLLRANGIPVARTYAGDLVDGAHVDKLNARKDGQIPLTEEGIDDDRAIFDRSGNDSVDHWKWIDLIGLGDFVGENFGKSVEEEVEEGEEQMQGEMEPSENEAVQPLVRTLSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4H9</accession>
    <name>A0A7D5Z4H9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Complex I intermediate-associated protein 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cia84</name>
        <name evidence="1" type="ORF">G6M90_00g077060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987208.1">
        <property type="nucleotide sequence ID" value="XM_066131065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4H9"/>
    <dbReference type="GeneID" id="26241428"/>
    <dbReference type="KEGG" id="mbrn:26241428"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF1">
        <property type="entry name" value="OS04G0684500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="QLI71283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="792" mass="90778" checksum="CE9284A6494489B1" modified="2021-02-10" version="1">MRVNLARHGRRFLVYRPTSAPACLPCVPPTRRRPISRPVVQRTFARTFLNALFQKPPREIRQPEYEPGWMQVMVWRSRMLDNLRPPPRKELIDALRKLMQSKLKRKMPLNSTQALQCRRLLEYLTTSDGHDQHSKSLSSADLSMIRQVLLDIEPQERSENHLELAKSLYAVWSSGNHTGKARPPQLQWSYFIKMLCEYGGSEEALLMLKSKWADPSYHAYLVKEDRLLASVAHGLAREGKEAELVELVNYAMAHGVPYDATIQAVMVRYFANNDKVTETQYWFSQPIDQKYCQAQVYRDIASFARRNDLQEWAGPLILELGQSQPKRKHWDAILQSILLLGRSLAEVEAIMGHMVDRNGALAPTISTINGLLTVAIETQDSELGEGILALCAERGLAPSGETYLRLLRLRLEAVDLKGAQRAFEQVKHFEPWNNENGSDLFDDFRQSSNKYLTLLSRQVPPDFKTILALLDALEEEQMLLDPETVAALCVKFLENDQHFDVMDLLSLHSFLYSEQQREVVQHAFVTFCLDKGTSTSRAWGAYQLLQQFFQDTSYELRMKLISSFFDRKRPDMASHVFGHMRQHRNKTYHPTMDTYILYLEGVAQNPDPEGLVLVHNMLKMDTTIQPNTKLYTGLMLAYAACDKPTTSLDFWNEIIQSREGPSYASLQAVFWALEKKSGGDKQAREIWERIERMDLEVPQAVYSAYVGAVAGSGNEKEVRGLIMNMASYVGSEPDSMTLAIAHNALPGQELQANYRDWVKKKYRATWAELDKVGRRLNEYGLCQIKIKRIMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z4T3</accession>
    <name>A0A7D5Z4T3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin light chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KLC1</name>
        <name evidence="4" type="ORF">G6M90_00g063980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542486.1">
        <property type="nucleotide sequence ID" value="XM_014687000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z4T3"/>
    <dbReference type="GeneID" id="26244435"/>
    <dbReference type="KEGG" id="mbrn:26244435"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="253"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="396"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="764"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI69187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1030" mass="116400" checksum="CC3921404395C662" modified="2021-02-10" version="1">MTALRPSCREDFEIAIICALPLEYNAVALLFDEFWDGDGDQFGRAASDDNAYKTGRIGKHSVVLALLPGMGKVSAAAAAASMRSSYVALRLVLLAGICGGAPYYNRDEILLGDVIISKTVIQYDFGRKYPDGFARKDKTEGNLSKHNKNIRTLLATFETDLGGDGLQKKTSHFLRQLQAKAGDHRTRYKYPGTAEDKLFESGYRHKHRISPACICSNCHGRTDPVCAGALASACNDLGCDERYLVKRNRLKARRKLEQGGNNEAQDPAIYTGTVASGDTVMKSGEDRDSIFQKEGVIAFEMEGAGAWEEVPCIVVKGVCDYADCHKNKKWQDFAAAASASAAKAILERYIQTDKRRGVVVEEPPCHFLVPFGRNQSFVGRETILSKLLGRIWPGTNKDDCQRTAVEGLGGIGKTQIALEAVYRVHEEHPDCSIFWVPAVDVNTFENAYHDIGKHMKIKGINEENADIKRLVKTALSDDSIGSWLLVVDNADDITLLFGVTRLSDYLPFSRKGSILFTTRNHEAAVKLVVHKSGIVPVPEMDRSEAFDLLRKGLNESQRSDTKSTERLLDFLAYLPLAIRQASAYMDKNQILTSEYLELCESEREDMIDLLGRDFDDPHRYKEIPNPVATTWLISFHHISRHNPLAAEYLKFISLLAEKDIPKSLLPTARKIKALEAIGTLKAYAFITQREGRDSFDMHRLVRLAMQNWLENKGLESYVSSAIQRLDQAFPFPKHKNRDMWMKYLPHAQAALEFREHLEGGKVDASLLFNVAESYYLLGQYQKAKQLHQQSLQLREKVLGKEHPSTLSSMNNLANMLSILEKDKEAEQMYYQTLQLREKVLGKEHPSTLDSMNNLAGVLLDLGKYKEAEKMYCQTLRLYEKVLGKEHPSTLSSMNNLALMFRNIGKYEEAEQMHWQTLRLYEKVLGKDHPNTLTSMMNVAIVLSKTGKYEEAEQIHWQTLQLREKVLGKDHPDTLFSMKNVANTLLNLEKYEAAEQIYRQILQLKEKVLGKDHPSTRRSQRDLDDCLRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z539</accession>
    <name>A0A7D5Z539_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gntK</name>
        <name evidence="10" type="ORF">G6M90_00g111580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543707.1">
        <property type="nucleotide sequence ID" value="XM_014688221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z539"/>
    <dbReference type="GeneID" id="26243094"/>
    <dbReference type="KEGG" id="mbrn:26243094"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI74264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="172" mass="19527" checksum="C3C149323F5BD78D" modified="2021-02-10" version="1">MGFIYIRAHGFGKVHGGEISCLQLQPKANIDKIHNGEPLTDSDCEHWLEAISEHVSDYEKDQVHQRRLIIICSALKRSYRELLRQSCHHAGYSVVHFVYLDAPESELRRRAEAKHDDFPESNLVHSQFQKLERPGIDESDATIISVVPPLEDVQTAALEAVSKTFIDKGVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6E8</accession>
    <name>A0A7D5Z6E8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g111600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987832.1">
        <property type="nucleotide sequence ID" value="XM_066131832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6E8"/>
    <dbReference type="GeneID" id="90968259"/>
    <dbReference type="KEGG" id="mbrn:90968259"/>
    <dbReference type="OrthoDB" id="4938069at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27446" checksum="8EDEA3A925FD4E6D" modified="2021-02-10" version="1">MSSTLVQENGEPQTIETSQGSMIVSSDLLMGSRVVADASLAAISYPNDEVNSSASPEACLSSSTLTSPNVLRDGVVSVQAESQVERYPEQNGEEYHAPSHYKDGENWAIDPQLCASGFLDYVQSQGELSIPTSQLSDNTQDMEYLPLDTRNCVGFPRPPPTSRQPTLLTPSGVLNDRSSSSETPSNDGSSSNIPSYMTPNAIRARNLILRCNLPRRSSKISGHVRNVKRRVSVSEDFWPSKRQKLDSTCCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z6V4</accession>
    <name>A0A7D5Z6V4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g064810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540063.2">
        <property type="nucleotide sequence ID" value="XM_014684577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z6V4"/>
    <dbReference type="GeneID" id="26247099"/>
    <dbReference type="KEGG" id="mbrn:26247099"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="144" mass="15334" checksum="04B9329B1079A0DC" modified="2021-02-10" version="1">MPSVSASRERKVNDQKHGSNRKGTMPRIAKSTSKLIANQNNARSTAAGRKRSLEPAHDDQTSTTTSGISKRAKTGSIRSKEPTKLATINNAPTAKLTVLVFGGGEMGELGLGPKKTKPYVLRATHICLLSLLSKSPVAACILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z796</accession>
    <name>A0A7D5Z796_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">POP4</name>
        <name evidence="10" type="ORF">G6M90_00g073630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545702.1">
        <property type="nucleotide sequence ID" value="XM_014690216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z796"/>
    <dbReference type="GeneID" id="26241735"/>
    <dbReference type="KEGG" id="mbrn:26241735"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI71027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="226" mass="25754" checksum="CB4238FD2B167790" modified="2021-02-10" version="1">MAATTPQQLTKDLLARAHSPDSVNRIYNEKILHRALHLRPSSPPPAAVNARTARRKIRDQKKARSKARPKPLSSRERRKLGLYDIPKDGQKYSIYEPLYELWQGYAREILGRDIFRRGPEAAAKLASAELHGALTEVVRSRCPGRVGLKGIIVRDRKFVIEIITEKKGIKIIPKEGTTFRIEVRPETTQTASDSKPFVFEVLGDQLMLRSADRANRKFKQHFLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7B7</accession>
    <name>A0A7D5Z7B7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">G6M90_00g073610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545704.2">
        <property type="nucleotide sequence ID" value="XM_014690218.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7B7"/>
    <dbReference type="GeneID" id="26241737"/>
    <dbReference type="KEGG" id="mbrn:26241737"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="770"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QLI71067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113979" checksum="8527AD8AC52CBBC2" modified="2021-02-10" version="1">MAAHSPDPAAWKMSASSSHHDAATNLSILAEGQTAARLIQAHVAEVASSPRQKQPAAPSTVDISAIPSRESLYVGLAALDIFLQANVTGPVVPADRLALIQSRFSKAWTAPLSADTDQSAALTQLHKACLAHLEVDGVSPYSHIPHLELFSLARYVFKSVLASETMTSVDVYFQDEESRSVKYSLSWIRLRINIWHYKLLTQPSLGPGSNFTKSSQWSEVPSLVSRILIDMDTVRDQIAGNEVWSEAGSWGREDKAYFLVEAANNYILLGRHGKAKDALEEAAQLTGLKYALSGALGKRTKFQENSVSQLVVLARSSTDQDLIEEDGGDEEKAKPDALKLNDDTLLEEIQFSTHHDKDGYKEKELPPSLADVSPDNQPQLAPLDQIILLTEATLKDAFSPVDTLTSQEILPYAVRVLADKSTNWQIYTQALLVRSRIEVHRSRTVERGVLQLQAVADQVLTDTNVETELTKESDERTTNESDVPAIQVTAPGHENAVPSPKAQVPTSFLPAPKATESAPAHVRLRYIDALSTPPRWHLESELAYAWAGVGSLTSALEIFKRLRLWAEVALCYASAAASEDEDGRGSGGDEKAKSIVRWRLFHPTAEDASATSDPDDQDVEDVMHLKASSFEGPERSPPPPNAARLWCILGDLENNPKHYEQAWIISKQRYARAQKSLGEYYLAQKDMVKAREAYKLATSVNRLSPDLWSRLGDISLRLGQFDDAAEAYSRSIGTANDVAGGEDARTWSNLGSALWSLYCEVTAEKKGTVPANNETKAAARADDEEEDDVLEDPGDKSRDPATLLSKSLAAYKKGASIAHDNWRIWDNVLTLAARMQPSDVPDMVLAFTHILRIRKTEDAIDADVLTALLQDVVISKEKPAGTGIYEPPRGSRERLVTRLLEEEIVPLITHRAELWSLLSRLRTWRRDYAGAIDASERAWRAAVGSSGSGLLPGEVAADSADWTTDLKGWTEVVKRTDELVSILENWAHDVDTVGSKWKGKARSAIRSVMSRGKENWEGSEGWNTLEALMEGLKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7F8</accession>
    <name>A0A7D5Z7F8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MES1</name>
        <name evidence="18" type="ORF">G6M90_00g077760</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI71167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545329.1">
        <property type="nucleotide sequence ID" value="XM_014689843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7F8"/>
    <dbReference type="GeneID" id="26241362"/>
    <dbReference type="KEGG" id="mbrn:26241362"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="439"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="571"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QLI71167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="644" mass="72624" checksum="6C9AD8C896EA2846" modified="2021-02-10" version="1">MPVDNPILPVEGKRNILITSALPYVNNVPHLGNIVGSVLSADVFSRYSKLRDRPTLYICGTDEYGTATETKALETGQTPQQLCDEFHVKHKEVYDWFEIGFDHFGRTTTQKQTEIVQDIFLKLHENGFLEERTTTQPYCEKHDGYLADRFVEGTCPKCGYDDARGDQCDKCGGLLDPFELINPRCKVDGAQPIPRDTKHIFLKLDMLQSDIEKWFEEAHKKYGWPQNGVGITQSWLTKGLEGRSITRDLKWGVPIPLPGYEKKVIYVWFDACIGYPSITANYTDEWEKWWKNPDNVTLYQFMGKDNVPFHTVIFPGSEIGTGYKWTMLNHLSTTEYLNYENGKFSKSRGVGVFGNQVKDIGISPSVWRYYLLSNRPESGDTQFEWQNFALANNSELLANFGNFVNRIVKFVNAKCDGTIPEYSATYTDDTFDFAGWILRVNALLSEYVDLMEKVHIRAGVKKLMEISTEGNTLLQYRLDNTNLVEKPERTKTVIGLALNLCHLLASLASPYMPSTSESICKQLNTTLAFIPDVWDPEILKSGHKIGKAAYLFTRIDDKKVAEWKTAYGGSAESRAAEEAAKRKKQEEKEKKKARKAVKAAGGTQATTGENSASKEEKKKEDGAAVPPAAGDTKDLPIRVKPDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z7G9</accession>
    <name>A0A7D5Z7G9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA excision repair protein ckn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ckn1</name>
        <name evidence="7" type="ORF">G6M90_00g075220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545574.1">
        <property type="nucleotide sequence ID" value="XM_014690088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z7G9"/>
    <dbReference type="GeneID" id="26241607"/>
    <dbReference type="KEGG" id="mbrn:26241607"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="119"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI70866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="484" mass="52580" checksum="E82B1F68145B8B55" modified="2021-02-10" version="1">MQARLLSRETGDHSPDDLSESVNADLLRSFAPAPQHRFNGEIASQTHLEETEERARSVRAHGAGVSGLALEKFDGRILVSGGSEGSIKIWDLDEAPTPNQRHVFRPVSTIARSTGGKKVNGHSHGITHLAFYPFDPDAFLSSSYDKSLKLWATQRSALTADFHLNATIYSHAMSPIADHLLVSCATQHSNVRLVDLKSGSAVQALVAHGGPVLCTSWSPRHEHILASGHADGKVRVWDIRRAGGVIAQLDQEDSLGVLHRFRHATALDQDWSSMPHFRTSAQAHDEAVNGLQWTDDAKYIVSAGLDRKIRVWDAGTGANTLASFGALIQNRHAKTATMVVTSSGLSNSKEILIWPNDQEILLLDLHDGNVITRLRSPGSTNPVGPRGGELGRNRTTTIVWRGAGGGPGQIGTVMGGGNSVGAIYSAHLDGQIRAWMPQIPGPEDIDETEDIDEDEETRRRKRKAVDNAYRSLMGRQITFTGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z843</accession>
    <name>A0A7D5Z843_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g112070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065987897.1">
        <property type="nucleotide sequence ID" value="XM_066131845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z843"/>
    <dbReference type="GeneID" id="26246873"/>
    <dbReference type="KEGG" id="mbrn:26246873"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="194" mass="21207" checksum="17546F696C5E9649" modified="2021-02-10" version="1">MAQLDAGKHLYFIPESQICGRIRPHRQGQGLFSIEVGAAHAADVMMAAIPRGEELQIQLYHDSDTIPANQMNWIRQTLETSTGTWPAATGSSPLSVGEAQYAPARCPSQGARDVVIQGWKELGLAVGLGDKGSIFADDADIVSAKLLSEYYQYRGYNVSVKDVIRHASRLLQGHMLDGKSPPRTLQEEGAMRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8S4</accession>
    <name>A0A7D5Z8S4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RHM1</name>
        <name evidence="6" type="ORF">G6M90_00g087580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP058936">
        <property type="protein sequence ID" value="QLI72307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542358.1">
        <property type="nucleotide sequence ID" value="XM_014686872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8S4"/>
    <dbReference type="GeneID" id="26244872"/>
    <dbReference type="KEGG" id="mbrn:26244872"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="94"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QLI72307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="461" mass="51474" checksum="51F2FA5A0CDFB71B" modified="2021-02-10" version="1">MTRRLWKSLQLGVSSGPRRQTKAASSSSSASASSSPSLSLPPEISAPVVSDGVGSSNAVNGTHSYLQDLDVWKQAPILKGTTNFEPRPDVKNIMVTGGAGFIASWVVRHLTLTYPEAYNVVSFDKLDYCSSLNNTRVLDDKRNFTFYHGDLTNPSEVLDCMERYRIDTVLHFAAQSHVDLSFGNSYSFTHANVYGTHVLLESAKKAEIKRFIHVSTDEVYGEVKEDDDDLVESSILSPTNPYAASKAAAEMLVQSYNKSFKLPTIIVRSNNVYGPHQYPEKIIAKFTCLLNRGRPVVLHGDGSPTRRYLYAGDAADAFDTILHKGHIGHIYNVGSSDEISNLDLCSQLLDTMGIDHSTSEQFRKWIKYTHDRPFNDRRYAVDGTKLRMLGWSQNTSLEKGLKTTVDWYIKYGESWWGDISHVLTPFPMVSEGEIVPDFEHLMKDDPVQPGDECLANDKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5Z8Y5</accession>
    <name>A0A7D5Z8Y5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Minichromosome loss protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mcl1</name>
        <name evidence="10" type="ORF">G6M90_00g072380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058935">
        <property type="protein sequence ID" value="QLI70768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545825.1">
        <property type="nucleotide sequence ID" value="XM_014690339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5Z8Y5"/>
    <dbReference type="GeneID" id="26241858"/>
    <dbReference type="KEGG" id="mbrn:26241858"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="414"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="738"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QLI70768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="849" mass="95399" checksum="B62DCC97C57F5FB2" modified="2021-02-10" version="1">MDSTASRPRPRPAHTQGTTRCAYTTDGNRLVTVGSNNTIRLYKTGSDGEPTNIDDCQEQNVSISAGKDFFVVGSEDGTVSLYNIEAANFERFLLRTTLPIRDVALTRDCQWCAVASDELSVKIVNIMDITQMKHLREHSKPARHVSLEPHGRLAALSCTDGIIYIYSLTSEEPELIRKVDGIIGTVDSDSEISTKVAWHPDGRAFAVPTPTKDIQVISKNDWEKQRRFADGHLADITALSWSPNGALLASAGKDGKVLVWETKTQSVIQRFDYSNVVDLAWHPSKNILSFATTDGEVFIYSDFLHDQFSPLLKLNTQPAPFIHDPLSEISGNRQQPPVNGHKIQPIPSRPRRDSLDSIGSLLDEDGEDDGFVVDDDGAGYAVGRGSKRGRDPDETFGGPSSKRAHLMQPQHHECFQPGSTPWMGNRKYLCLNLIGFVWTVDQDSHHTVTVEFYDHEFQRDFHFTDTFLYDKACLNESGALFSSPPKDDAPAYIFYRPHESWTQRSDWRTQLPRGEAVTAMSLSESFITVTTSANYVRVFTLFGMPYRVYRPKSSPMVTCASWRDYVLTIGNGPVGSDGTARLLYTIENIKRDEICQNEDTVALPEGATLKSVFFSDNGDPCIYDSTGTLLTLLHWRQPSRACWVPLLDTKLLSRLASGRKNETYFPVAVADHKFHCIILKGGDKYPYFPRPLLSEFDFSIPLASPSEKKKKSDDTEKEQDEVMDEDKEEEGEDFETRKLEQQFMLKGVQAAQLRDLVEATSGNHTQRSLLSRIELEIDKTLLQLLAVECRQGEDRGMRALEMVELMRDRTGRMMEAAGKVAERYGRTVLGEKIREVGEKRVGVMDEEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBK6</accession>
    <name>A0A7D5ZBK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Periodic tryptophan protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PWP2</name>
        <name evidence="9" type="ORF">G6M90_00g096540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058937">
        <property type="protein sequence ID" value="QLI73708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546680.1">
        <property type="nucleotide sequence ID" value="XM_014691194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBK6"/>
    <dbReference type="GeneID" id="26241103"/>
    <dbReference type="KEGG" id="mbrn:26241103"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001292">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="468"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="746"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI73708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="893" mass="99165" checksum="5544992E91E9295E" modified="2021-02-10" version="1">MKTDFKFSNLLGTVYCQGNLLFSPDGTHLFSPVGNRVTVFNLVENKSHTLPFAHRKNISRIGLTPRGNLLLTVDEDGQAILTNVPRRIPIYHFSFRSKVTALSFSASGRHFAVGLGRVIEVWHVPSTPDTNADGELEFAPFVRHHRHTGHFDDVRHIEWSSDSRFFLTASKDLTTRIWSLDQEEGFSPTVLSGHKQAVLGAWFSKDQEIIYTVSKDGAVFEWRYVKPINPKEDEEMGETDDDSNMRWRIVQKHYFMQGSAHVRCAAFHPESNLLVAGFSDGIFALYEMPDFNNIHKLSISQNDIDFVTINKSGEWLAFGASKLGQLLVWEWQSESYILKQQGHFDSMNSLVYSPDGQRIITTADDGKIKVWDIESGFCIVTFTEHTSGVTACEFAKKGNVLFTASLDGSIRAWDLIRYRNFRTFTAPTRLSFSCMAVDPSGEVVAAGSLDSFDVHIWSVQTGQLLDQMSGHEGPVSALAFSPNGDSLVSGSWDRTARIWSIFNRAQTSEPLQLQADVLDIAIRPDSLQLAISTLDGQLTFWSMADAEQVAGLDGRRDVSGGRKFSDRRTAANVQGTKSFNSIRYSTDGSCLLAGGNSKYICLYSVTTMVLLKKFTVSVNLSLSGTQEFLNSKHLTEAGPVDELDDQGEASDREDRVDRSLPGSKRGGDPSARKKLPAVRVNGIAFSPAGTAFCAASTEGLLIYSLDNTVQFDPFDLNMEITPASTLHVLESEKDYLKALVMAFRLNEAGLIKRVFQAVPPSDIALVVGDLPTVYVSRLLRFVAAQTEESPHIEFCLLWIKALVDKHGKWLTANRGKMDVELRVVSRAVSKMRDEIRRLADENVYMVDYLLGQAGKEVAMGKGVKMVTGGERMAIDAADGEEDTDDEDEWIGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZBQ2</accession>
    <name>A0A7D5ZBQ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline utilization trans-activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PUT3_2</name>
        <name evidence="8" type="ORF">G6M90_00g112620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540329.1">
        <property type="nucleotide sequence ID" value="XM_014684843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZBQ2"/>
    <dbReference type="GeneID" id="26246923"/>
    <dbReference type="KEGG" id="mbrn:26246923"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="264"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI74066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="631" mass="70611" checksum="ABCF821AD01A677F" modified="2021-02-10" version="1">MANTTGQGDFTPMTQTNQNDSCTSWNSANVSRRLQPQPNLQAMEQTDSRNTVVQDDQLDNSISESPDTAPLTNPLSTGPSTFMLSDTGKTFYLGHSSNWSFTRRILSITYEHVHRVSLPSTALMFDGKVYMLDWSSASAQPVLPNLDYAIHLINNVKFHCSPMYHLFDEDVFLNSLHAHYRGDQTPRGLVQQLWFIQFMLILAFGKALTSKSSRNNQPPGASFFTHAIHLLPNMAVLWDEPVQAAEILCCIALYLHCIEHRGSAYNYIGQAVRLAMSHGLHTNLSSHHVENALVPRCRRIWWTILVLDRQMTYLMGLSQSIRDDDVTAPLPEFEGDGFRTAAFAMRTRLSHFIATIDRAIYGPDGRLSSNFLLRTKDTLASMAGLPDELHRQFPLDLNSKRVGVSRLSAHIHLLFHQCIILATRPVLFCFYKIRLETPRLYRHIFNSSHAVESLLRMCLDSSQHVISILECLQGEGLIETFLSYDLEALFISMTNLLAAPVLYQDSGSAWTSWRQRAYAILGEISKCGNLIAQYQQSELRHLEQMIDGLCMAETIEPAQPSREDGTDVSAVADVGPLGFSVAEDALPSPAADDVLDGNYIGAGFSTAQIMDMVNSIDTEHGEWMSQALFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZCF3</accession>
    <name>A0A7D5ZCF3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g113880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZCF3"/>
    <dbReference type="GeneID" id="90968297"/>
    <dbReference type="KEGG" id="mbrn:90968297"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="119" mass="12246" checksum="E42DD4F5B68E55CD" modified="2021-02-10" version="1">MVGLNNIARDSPPQKLRCSRSVPSDGSAAATDCIRRVKAGSLSIHSPQARLALLLGALGVSRTIHATAVNTRNSSTGRNNETGNTTIGSCSTTESTLHQPGILLALGRVLLLSQLSTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZDZ1</accession>
    <name>A0A7D5ZDZ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g111860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
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            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_066131839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5ZDZ1"/>
    <dbReference type="GeneID" id="90968264"/>
    <dbReference type="KEGG" id="mbrn:90968264"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI74129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="62" mass="6684" checksum="8AD3B5DB2A550EE3" modified="2021-02-10" version="1">MSTSPLCPVCLLRGNKRPACLDDAAETTKLQKEGFARPKGAECRGFGGTDSFMSSQEPQLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5ZE73</accession>
    <name>A0A7D5ZE73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">P5CR_1</name>
        <name evidence="7" type="ORF">G6M90_00g112640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058938">
        <property type="protein sequence ID" value="QLI74349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540331.1">
        <property type="nucleotide sequence ID" value="XM_014684845.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="26246925"/>
    <dbReference type="KEGG" id="mbrn:26246925"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF27">
        <property type="entry name" value="HYPOTHETICAL PYRROLINE-5-CARBOXYLATE REDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="6">
        <location>
            <begin position="206"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="96"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI74349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="319" mass="34331" checksum="9FDB860E759CA287" modified="2021-02-10" version="1">MNPEGILVSWHSFNRNAHGETTKLGNLGTAILGGLLSTPKEGPEGICPFSQFIVSVRTEVSVTRLQEEFCQHQDKLRIYQNQNERAVDESDVIILATDPADVASVLTAQGMRDNLVGKLLISVAAGWTRQKLETMIYGREIIPEEISGVDYPKQVWVIRTLPNVAAVVHQGLTVIETPQPELPTRYLALTRAIFDRIGKTIVLPPSLLDAATVVGGSTPAFFAIICEALIDASVAVGVPRDVAHAGIAQAMLGTAHMLQTGMQPAAIKDKGTSPEGCTMSGLMVLEETAVRGHVGRALREAVTVARLMGSDVHLNDTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQ05</accession>
    <name>A0A7D5UQ05_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase-like protein ustD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ustD</name>
        <name evidence="3" type="ORF">G6M90_00g000890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542979.1">
        <property type="nucleotide sequence ID" value="XM_014687493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQ05"/>
    <dbReference type="GeneID" id="26244352"/>
    <dbReference type="KEGG" id="mbrn:26244352"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43586:SF21">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE (PLP)-DEPENDENT ASPARTATE AMINOTRANSFERASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="68"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI63751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="467" mass="51585" checksum="893653D7C49C9AB8" modified="2021-02-10" version="1">MAWSNEPKDGQNDSSTHAPSHPNGSSKLESAQCAIYAVTAGESASDVMDMDRVRPHFPVLSGKTVPFNNAAGTVVLKEAIEAASDLMNGMPIDHGLGDPRSTAARAEYSNNWHQCAAFVNAQPSEIAFGQSTTALLRLLGQSLRPHLGSDAEIICSTLCHEASASAWIHLARSLGTTIKWWTPSQEGEDDPCLTVDSLRPLLTPKTRIVTCNHVSNVVGTIHPIRELARLVHTIPGCVIAVDGVAWIPHRPVDVKLLDVDFYCFSWYKVFGPHMAQLYAHRRAQDRYMTSINHFWRDHATLDGKLHLGAACYELEAMCGPIAKYLGDLGWDAIIQHETVLTKVMLDYLLSRPTVYRVFGKRTADPSHRVSIVVFEVLGRQSSDIVMQVHVRDRFRITWGDCWAPRPTFDVLRPHSDGIIRVSFVHYNTVAEVQGLCAELEDITSTKGAHVAERGDSPSKDIVELAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQC4</accession>
    <name>A0A7D5UQC4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g018950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI63991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548645.1">
        <property type="nucleotide sequence ID" value="XM_014693159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQC4"/>
    <dbReference type="GeneID" id="26238089"/>
    <dbReference type="KEGG" id="mbrn:26238089"/>
    <dbReference type="OrthoDB" id="4152802at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI63991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="733" mass="80849" checksum="A045FEA76C0C8352" modified="2021-02-10" version="1">MALWPFRRKSTRKRSRSGAALSDNEAAPVRNQADAVPAKTASKKARTEPAKLQRRPRTYSFSPGRHDSIRIDRARRNAEAANQPRPNPDNEQASGVAWERTPTLHPTRRKSSKRRRDDHDREAEIKAMSAYMPARVAADGHARSNSKQATKRAKTGGLSHQQVPASQVSLPYPDSVPSAMSVDSDFISYKISALDSLAPRPTLKYTPSMRYTTSRGTTSGAAESLKKPLGERQPIQENQFDSRKRMDDLANELDAKDLRELMERDNRRRERRRQQDQERMDRRLARRAERHRREKAEAQKAGTPPPENLERGVMGRELVGLGIEPASAVVTSSKRRDSDTLPDAPADMEDDAEPPKPLESFHRPETSSRDDEPAPSQEQTLLTPPRIEEPQQPVSASPQGSKLAGMLRSKKSRSKSTLGSDKDQPADGASGRKNSECSTKAGSRLSFSSLLKWGSRNQRYSGPSSFSNTSREEMQAAGAATQNQAQAEALARLQGEDMSNPANYLAAKAGAGIPKRTKSRFREDLPEFPLSPPDSRVQSPEADPPLPVLAEKSSEIDSRPTPPSRHGTPPSIERPQGAQSAEPHVSISLASIDSEGSWLSGRVGSMRMSVKRDSLLRAHRRENAPSESPTNSTREDLAIADDEYLSRLAPDRSPGTVASGRRSGEGRPSSDAGESITITDDVKWGRVGAKPEVVQFHNHNRDTIRSQHGLLNIDSGDEEDNAILIYREVGHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQF8</accession>
    <name>A0A7D5UQF8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Vacuolar aminopeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">APE1</name>
        <name evidence="11" type="ORF">G6M90_00g003240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">4556</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014541982.1">
        <property type="nucleotide sequence ID" value="XM_014686496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQF8"/>
    <dbReference type="GeneID" id="26245013"/>
    <dbReference type="KEGG" id="mbrn:26245013"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QLI64233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="556" mass="59871" checksum="8602E8548BE66A9A" modified="2021-02-10" version="1">MTRRTPLPSPQSSVLPLRQPSAPAPAPAPAPVTTTITTASPKSKNFILADMDGRASRENRACASCISKLTPSEIGQVNWHLAQDQACRLCQVAQCKPEAFTKPFCDFLQENPTVFHTVDYFKRKLSDSGFEELSARDSWNGKVHPGGKYWVTRNGSTIIAFTVGAAYKPGNGVAMIGGHIDALTARLKPISNRPSRAGYVQLGVAQYAGGLNQTWWDRDLSIGGRVVVRDPETGKTSTKLVKLDWPIAKIPTLAPHFGVGMFGNNNKETQAVPVIGLQSSSQHDAEPLGPEGAFVNTQPPRLVQLIAKQLGITSYASILNWELELYDSQPAQTLGMDREFITAGRIDDKLCSWAALTGLLAADTNTDDSYIKLVALFDDEEIGSLLRQGARSNFLPIVIERTVEALNPSTYGPGLLGQTYAKSFLLSADVTHAGNPNFLENYLDDHVPQLNVGIAICGDSNGNMTTDAVSTAILRRVGEIIGAKTQDFQIRNDSRSGGTIGPSLSSAMGCRAADAGLAQLSMHSVRATTGALDPGLGVKFFKGFLDLWEQIDGEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UQP3</accession>
    <name>A0A7D5UQP3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TUBGCP6</name>
        <name evidence="8" type="ORF">G6M90_00g024090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548171.1">
        <property type="nucleotide sequence ID" value="XM_014692685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UQP3"/>
    <dbReference type="GeneID" id="26237615"/>
    <dbReference type="KEGG" id="mbrn:26237615"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="171"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="588"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI64470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="953" mass="107204" checksum="2F108E57AE844CB3" modified="2021-02-10" version="1">MTDEPSEADVFAIPDFWKTSRWLDQLASETSTSLFGHGLDALYNVKSTSLPLEPIAVDTDGFFKLPEVGESHADDPDELQDSDMTASTIQEHQEFEDKSDIWTGVSEPQPRPSAFRTWETFKTGTLQPYIPMLLSEAGQGAYDALLSWPTDSLNLQNTSTPAVETRAYFTSVLALCLGRESVFFARTTEDWTFKCTLPELRVSGYSRQVLQGVQRQAAKCGSTFLRLGAFCQSSYAPSSSRCAIALASAMSQILQAVEHRVSVDGRFPESLLQLQTTIREASTILRPLDDLAARIPRDLPDEEILSLVFQEASTFEFSERYIRDMLCEILQRISSPWVESVEEWLGTRREVGMPFARSNIGETKGFVTVDVEVFIDDFGREVEDIDFRLDIGRVPQFLPSDIAESIFETGRNLRFIRTFHPDHILARSDVIMSNRPPAARWLFDWASILDLEDRIAQYQDGILDAIQESRSATAYVAVHSKLGVDEPDSDLELTFFGVDESTMEQRLIESMDHFSRPLIESSSDDSLSRIVQEKFSSEIEDDSIASDDTPHWSLLPILSFGGIAAAQARIVNRESLRLLFEANNVQLHLKLQRDFHLLGNGLFCSRLSHALFDPDLETTERQAGIAMQGGVMGLRLGGRDTWPPGSSELRLALMGVLGEAYGSQGVTKASTSINRDSGASPLPGDLSFAVRDLSEEEINKCMNPDALEALDFLRLSYTTPPELTWIITPVHLMHYDRIFKLLLRILRMLYVVNRLYQDTNSRLNTWVEEDTSYRFVRESQHFVSSIASYFLDSGVAIAWQSFENKLNSIRVHLDKPDAAPDKCAYSPNQLRDMHSQVLERIMYALFLRKRQLPVLKLLEEIFGIVLQYAKQSRLQALGEEGESAELANSAHMYAEFRKKVQVFITVCRGLSEKARASSKNTADGASSEDSGFGDDSLIAQLLKLDMGDYYCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5URC3</accession>
    <name>A0A7D5URC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g002230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI64917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542858.1">
        <property type="nucleotide sequence ID" value="XM_014687372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5URC3"/>
    <dbReference type="GeneID" id="26244231"/>
    <dbReference type="KEGG" id="mbrn:26244231"/>
    <dbReference type="OrthoDB" id="4939599at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI64917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32943" checksum="5BAD5CDD18264021" modified="2021-02-10" version="1">MSSTLRQNTPEQVNINMTRSRKTLSPSQLEHKRAHDREAQRANRRRVKERIVRLEQELEEKRGQLGSNKVYQELLRRNRLLEEEVARLKSTLTTSSTAGLSPAGSSSGSVPEGGGFVDYASSTDYSPNDMYRYLIPHSDFPSMATQVQHCDAVMAKGSHLLPVALDGIDIGSPTALYKPSSITYNTPETPATNIFHHADNCVIPAYGVDTPTAKLGGLQNGMHVRSGLWNNTRRHRDEGRSDSRCGLQAQVVAGGWDNNPTHKINMRYYQGEACFLASSPTLQHFPACYPGYGMNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USY1</accession>
    <name>A0A7D5USY1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metacaspase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">casA_0</name>
        <name evidence="7" type="ORF">G6M90_00g001670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542909.1">
        <property type="nucleotide sequence ID" value="XM_014687423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USY1"/>
    <dbReference type="GeneID" id="26244282"/>
    <dbReference type="KEGG" id="mbrn:26244282"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="162"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="456" mass="49034" checksum="71F18D48A87C4F3C" modified="2021-02-10" version="1">MSGYPGQGRYGAAQHHGGGGGFSQGQGPGFGYGYGNYGGPPQGPPQGQYGPPQGNYGPPPGQYNSPPPGNYGPPQGNYGPPPPGPRPPSGPQGYGHSPQPQYARPPPANPPPPGYDAYGYPMQGGTYAYRAQAGPPPPSAPQQFGHGAPQGYTFQYSNCTGRRKALLIGINYFGQKGELRGCINDVHNVSNFLMERYGYKREDMVILTDDQQNPVMRPTKDNMIRAMGWLVKDARPNDALFFHYSGHGGQTEDLDGDEDDGFDEVIYPVDHQQVGHIVDDEIHARMVKPLQPGVRLTAIFDSCHSATAMDLPYVYSTKGVLKEPNLAKEAGQGLLSALGSYARGDMAGVASTVFGFAKTAFKGDDAYNKTMETRTSPADVIMWSGSKDDQTSADATIANQATGAMSWAFITALKQNPKQSYVELLNSVRDILASKYTQKPQLSCSHPLDTNLLFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5USZ4</accession>
    <name>A0A7D5USZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">G6M90_00g005090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542155.1">
        <property type="nucleotide sequence ID" value="XM_014686669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5USZ4"/>
    <dbReference type="GeneID" id="26245186"/>
    <dbReference type="KEGG" id="mbrn:26245186"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="534" mass="58647" checksum="518A21B6577AC34C" modified="2021-02-10" version="1">MASATPHSEVVPGTVHLVDLRGAAAGEAGIVELVPKPSADPEDPLNWSRLRKHKVVAMVLIYTLGIGIPTSLQYSVLSDITEDTGISTAALVQGTGLMFLFMGWGCLVTQPIALVYGRRGMYLVSLLAIVPLMVWTAYSRSAGEWYAHRILLGLCSSPIEALPEVSIPDIFFAHERGTWMSLYVFTLFGSNFLAPILAGFFAEAYGWRWTMHFGAIIAALAFVILFFFMEETMYFRETLEGLEDVADSVHDVKDESTDEETNASSSTSHKSESYSPRRYGQKLKPFSRMEGRPSKKQMFLSMILPLPIIFQFPNIAWAGFIYGINLSWYNVLNATANPVLSAAPYNWSTSSVGLIYVGPIIGAAFGGLWSGIIADRLTLKLARRTKGVREPEQRLWPLALSAVLSCAGLIIWGVGAQHNVHWAGLAIGLGILTFGCVTGGSIALSYNVDCFKDISGESTTSVIIIRNTLGFATSYGITPWYTNMGLQNCFIMAGFLSLGCTGSFLLMIWKGKSLRRHCAKRYWKYVEKSSHSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UT82</accession>
    <name>A0A7D5UT82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-like-specific protease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ULP1</name>
        <name evidence="7" type="ORF">G6M90_00g007980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986047.1">
        <property type="nucleotide sequence ID" value="XM_066129640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UT82"/>
    <dbReference type="GeneID" id="26239154"/>
    <dbReference type="KEGG" id="mbrn:26239154"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="815"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI65879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115670" checksum="D014A88278089431" modified="2021-02-10" version="1">MSGSQQGWLSSLSSLPSLIFPPVSWFINGSPDGSSGAPANLLPLVYSESTVDDAEASETAADTPSSSFANSDASRPWLPRFPKLKRHYPPVERIRTERSPKANANPPHSYRNPRSFPRQRFLADTIYPRLEPSDPRQKDICFALSSLHRQRAPQEPSPAPRALRPPEHPNTVFVEINGIRTNKRRAEDLEVDLVAAIQNSTHTNPPSSISISRTGFFPESESKFQEEIQAHMSHAKPLPELITGMMTNILSTFSDLTGIFSRLLYNQAYEVSESRSYIQIKDPSGLDVAKKRVKLTSEKSDFQWLDRDGLHSLLSRYSHFRHCFDKASSILLAHPSRAEMNKLLKPLLPVLADNADDLNALSSGCDGVDLCRFWFYSWRSMMTYLNTVYEIGSFIKMKNKHHRAPTVWPNSPSSETLETAARIRRFLSDPSLFVVLKSILELSDELVNYPMPADMIDRVVLDMAAVQHNIVLPSYVQSEQFHERLLEYFPPPQRVDPDYACPVLPGAFPEADSEFHDVGLVEPEVPPLPSLSVEPPPRISKRGSTKTDRLRAKFFAAEISRLTPEEFQTKYCGPSDDHRNIENDYSTDFIGKKPLTTAHVGVVRSILKDRKAPKRLTMTRAPKAVRFTEGTITPRQRTHLGLDIRRLLPSSDRATDPVFIGNIKLGQSGPADDKLDVDEWEYLRAQQTNRHVNSIFHGAKISKHKPPANDAIDPSLAIERMLSVSSIESLAISDDTRAGIAIKKEQVAQQAAEDARKYAEERARQELEEKLARTGGLRAPEQPLVSPLSDHWQERAQETLRKSPRTTLAKTGDGIDLRRHDFAKVVKATEWLNDEIVNGCLNWLDQSINSAAGIKDVKKSTRKCLAMSSFFFKFLRENGFTKSERTLRRHGVEKKNFLHVDTLLLPICESSHWTLLVIRPSKKTIAHMDSLNPRGSQTYISLGLGWLKYILAETFVEDEWKVTQHEAPVQTNGYDCGVHTITNGMCVALGLNPIDTYTTEDMPQQRLRLASMLLNGGFTGEFDLRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTA3</accession>
    <name>A0A7D5UTA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HOG1</name>
        <name evidence="20" type="ORF">G6M90_00g025010</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">4556</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="18">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="18"/>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548079.1">
        <property type="nucleotide sequence ID" value="XM_014692593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTA3"/>
    <dbReference type="GeneID" id="26237523"/>
    <dbReference type="KEGG" id="mbrn:26237523"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QLI66350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="358" mass="41053" checksum="556251AD08736B57" modified="2021-02-10" version="1">MAEFVRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAVKKIMKPFSTPVLAKRTYRELKLLKHLKHENVISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQPLKNKFKNADAPAIDLLEKMLVFDPKKRITATEALAHEYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDYHNVEAGVAAMESQEFNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTD6</accession>
    <name>A0A7D5UTD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribonuclease NucA/NucB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">G6M90_00g017150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI65432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065985958.1">
        <property type="nucleotide sequence ID" value="XM_066129794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTD6"/>
    <dbReference type="GeneID" id="26238259"/>
    <dbReference type="KEGG" id="mbrn:26238259"/>
    <dbReference type="OrthoDB" id="2748312at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028911365" description="Deoxyribonuclease NucA/NucB domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Deoxyribonuclease NucA/NucB" evidence="3">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI65432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="252" mass="27063" checksum="5E4E82C6C362F215" modified="2021-02-10" version="1">MQLTAAVSLLFYALGLATPILDEPREVGPLSNISPLFPRAGTGDDKTDPIKAKVTVTKGSKKDPTGTGGNQLTFDVDCWAILCKDAPKVLQRVVKKRVTQNRKDSKACPSPYTRKKDPVTAPARNNKWAQSDFNSAEEYPFASSLQGGTGAYLVPVNGASQSTQGAQLANLYRANKILQFDPESTAAGASKGTWFELEFTGELGPYCDALARGDTSVCDDKHDASGPWGFDVAKFVSQWNAATGKYDYAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTE8</accession>
    <name>A0A7D5UTE8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">G6M90_00g016240</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014548904.1">
        <property type="nucleotide sequence ID" value="XM_014693418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTE8"/>
    <dbReference type="GeneID" id="26238348"/>
    <dbReference type="KEGG" id="mbrn:26238348"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="276"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI66039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="382" mass="40690" checksum="DA582EE18218BB7F" modified="2021-02-10" version="1">MASMLGTSAVLQGMADALPTHQQADDSSDLASSYEAIALLVHAYLAALGFRLRGFDQDKVIPDCESLAPRLPPKWNSGFGSLSFVYKHKQSSMDFVFRIDRMGAKVEVRGLAVGDENIHRFERTVRDIVNSAALPVRIAMTDGQEDRSDLVEKLRNVFVSGQAISDLLNDLKVKIVQKLIPKLQSEGYVETEDAEETARSERRGQERRNPQRPFEPSVEPNIPYHPPGPLPAMARPRPGAPVGDFPPPGFEDEYEINRPPRGNPIAMPGGRHPFNIGHDDLNPPGLGPHDPLRGSFVPGGLPHPGAPGGMHPTFDDPLFTGEGGNGGYGGYDPQAPPGARWDPVGPGGTPRFPGPGQGPGNGPFGGSGGFGGSGGFGGGHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTT2</accession>
    <name>A0A7D5UTT2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase 14 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuo14.8</name>
        <name evidence="9" type="ORF">G6M90_00g013340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549187.2">
        <property type="nucleotide sequence ID" value="XM_014693701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTT2"/>
    <dbReference type="GeneID" id="26238631"/>
    <dbReference type="KEGG" id="mbrn:26238631"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20266">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045299">
        <property type="entry name" value="Complex1_LYR_NDUFA6_LYRM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016488">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12964">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B14 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006643">
        <property type="entry name" value="NDUA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI66279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="124" mass="14702" checksum="13E92881C81A10A9" modified="2021-02-10" version="1">MAITPTQFAKKTAQSANWSDAKRRVLSSYREWIRAAPEIQTMYNMPLPISAIRTRVRQEFERNRYAAKLPVVDVLLFKSHAEYQEMMNFWKQTTHVMAYFKEENFRGDKRLPSSFMDGFLEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UTU4</accession>
    <name>A0A7D5UTU4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Choline transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HNM1_1</name>
        <name evidence="8" type="ORF">G6M90_00g031480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI66797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014543086.1">
        <property type="nucleotide sequence ID" value="XM_014687600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UTU4"/>
    <dbReference type="GeneID" id="26243887"/>
    <dbReference type="KEGG" id="mbrn:26243887"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI66797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="541" mass="58245" checksum="D6578FB145DD7298" modified="2021-02-10" version="1">MSLRREGYALDDMTGSKTSVTRASQKDVDDRHQLARLGKKSVLRRNFGFLSTVGFSCAVLITWEGTLMSFAPGLLNGGSAGLIWGFLIVWLCNISVFCTLSELLSIAPTSGGQYHWVAMLAPRRCSKFLSYITGWLTIGGWQGACASVGYLSGTMIQGLVAFNHAGYAPQPYQGTLMLWAVVVLAVLCNTVLSTHLPKLEGMLLVVHIIGFFAIIIPLGTFGAHGNAKDVFTTFHNGGNWSTQALSSFVGIVGSVFSFAGTSFPPGNANLLTMCEEVRNPSLVVPRSIIISILINGSLGLSIIIAMAFCNSDIEAALASPSGYPFMEIFYQAVGSRRGTTAMASIIIFMTLASVIGVIATTSRMFWAFARDRGLPFWRTLSKVDSTTCVPVWAILTTSAISCLLGLINIGSQVAYNALVSLAISSLYSSYLMAAGLLLYRRCTTGFSIPDPSSLPAVAETTGKELVWGPWHLPGVGGIINNVITCVYLSIILFFSFWPPSSEVTPDTMNFSILITGSLVLFSTVYYLVWAKKDYKGPVLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUD3</accession>
    <name>A0A7D5UUD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lovastatin diketide synthase mokB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mokB</name>
        <name evidence="13" type="ORF">G6M90_00g051200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986358.1">
        <property type="nucleotide sequence ID" value="XM_066130504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26247362"/>
    <dbReference type="KEGG" id="mbrn:26247362"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="17"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2545"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1162"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1032"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QLI67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="2635" mass="287624" checksum="79F692E3B4F84014" modified="2021-02-10" version="1">MSGRLSSHASGTDGDGLMPIAVVGMSCRLSGIATSPEGLWQMLARGLTGWSSNGSSRFQMNSFWHPQSDLNASFNARGFHLIKQDPALFDNLFFGVTNIEARAIDPQQRMLLEVAYEAFETAGITMQNVKGSDTGVYCAVSHHDYDKILGRDPELSPGYRFTGTGPALVSNRISYVLDLHGPSITLDTACSGGLVAVHEACKAIRAGDVAQALVGGTNLILDPDQVNIISSMDFLSPHGRCYAFDSRADGFGRGEGVAAVVLKRLDMALGDGDPIRAVIRGSNVCSDGRTPGVTMPSSDIQRRMIQRAYQQAGLDPRDTTYVEAHGTGTKAGDKAEATALHETFCKARQEGNRLFVGSVKGNVGHTESVAGLAGLIKTVLMLEKKMIPPNATFMKPNSDIPLESWGMEVPKRMLQWPDNATRRASVNSFGYGGTNAHVILDAADDYLDNMKHMCPPVAIRACEGKVNGDLAHEVAEVTETSSLAMTIIVSNPTEAEPTTTHVHGHSTLQHRRSLKASPTNAMTRPRLFPLSHDQEGGVAKLAANFKRFILDKLPDTNESLDSLAFTLSDRRSVHRFRWCVAASSRDELVDGLEHIVEGTDRALQQAEERKICFAFTGQGAQWAGMGRELLAAYPVFAKSMERSEKYLTHLGADWRLLAELDKPWETSRINEAALSQPCCTAIQIGLVDLLETWGIRPALVCGHSSGEIAAAYAAGIMTAQDCLKVAYFRGHLVKRLKEKKPELSGGMLAVGLSVGEAQKYLDNDATCEKVVVACVNSPASITLSGDEAVLSSIQETLAARGVFNRKLAVDVAYHSHHMNMILEEYLHAIQDIKPLHCGQHVQMVSSVTGRAVQGEELNATYWGRNLTSPVLFADALAEIFDTARKNEKRSNMLAVVEVGPHSALQGPIKQTIKASKTAGSISYHSVLSRKQDASRTAVALAASLFVNGATVDFGRVNDPHGDAKKNVLTNLPTYNWHHNTTHWVESRRSAQYRHRKFPKHDLVGVPSSDSIPSEPTWRNYIRLRELPWLKGHCIGGNTIFPAAGYVTMVLEALKQQILGGGNPWKKMRIKFRQVHFGRALLVADDSVGVETFVTIRPFTYTARESSASWNEFRIFSVSVNGESTEHSRGLVTAISPLPNQDHENMTDAESLAFIEQVSEKARIVLPPKQLYKELRDVGIEYSHPFNGQEHIRASESASTCRIKIPDIEALMPLHYQQPHCIHPATLDVCFQAAFSAMKVGDNLRGTFVLGGFDDLEISSEIPSQPGKHMSVAASLRGLGHSNFASDSVISSSDDGKSEVFIKIKGLILARTSGPSRQTSSQHLAGESLCHRLEWSLDPTCAEPHSIIKRCLLDPDVLVAGRTSMCEQYCQAVVAGALTELSPDDEAKITGHFSQWLLWMKSIRAGSYQPLQMGNALNDKIKSLGIYGEVLVDMAPRLVGILRGDVDPQALLLEKQRLYRLYTRDNIKRCHMQLAEYVKLLRFKTPNLRILEIGAATADGSMPVLEALYSNKGVAGEARSESYTLACAPTAFFQDAETGWDKAQESLEWKRLDMEISPKEQGFELGSYDLVIAANVLHATREINVALGNMRSLLKSNGKLAVMETTAPKIHDGVIFGMLPGWWLGATDGRVHSPLLDASGWRDRLGHCGFSGIDFEMHDFDSAEDHQVSVMVSSATSHPEPWCLGMQDPTRGVSTLESELPISKYPTNLTGSEGGPRQTILVISDGKESRLADHVAELLTSVESSVHAEKTMLAEAQVSPGQLAVVLLEAVHPFLATCSQADWGKVRHILSNADGVLWVSCGGAVEGTNPLQSLIVGLTRCLRSEDQHRKVVTLDLEPNHGSGLETAEQIRRVYHHVFGPHGPPASALPEFEYAIRNGEILIPRLMCNSPVNEYVQDSVSSYHPRHEQGMKPGRALSLKIHEPGLLNTLYWADSERHARSVGAEEVRVDLQYVSLNFKDIMIAMGQLEGHTAMLLEGSGKVVEVGEALRHQYSVGDLVFATDPDGVATTSVINKCNVHHIPRKLSMEVATAISLAYATALYSLRNVANLQEGESILIHSGAGAVGQAAISLAQYLNAGEIYVTVGSADKRALIRERFDIPDDKIFSSRGLSFYHQILRRTNGDGVDVILNSLSGEALQKSCSLLAPFGRFVEIGKKDVISNARLEMASLESNATFTTVDLTLLAKRKPLVHQELYRTIFELVGQDRIKVLSPITVSPVSELETSFRLMQAGKHVGKLLLQLDPDMAISVQPPRPPTPRLKGDCSYLVVGGTGGLGRATMKHFASLGAKHIFTLSRSGSDSPIMRELVEEMRLAGVCVVVFKGSVTDTVAIESIKEQAREFPIRGVVQGAMVLQDSRVDNMSYEQWRAAMEPKVVGTMNLHRVFGDTLDFFILLSSSAGIIGSYAQGNYSAGNTFQDSLARHRASLGLPARSIDVGSVEGEGYTANNEAAAEFVSRQGLQPYKVKEFLATINEAIWNPFPSGPSAAQLICGTRRADPSSQAKEAALQRPDPKFSHIWTKPHRQASAKADSSHFNIQAMFESAKTADEAEKAMQIAIKQKLAHLLGLPEKDVSTNRSVVSYGVDSLIAVELRNWILSQLESHVQIFELMSPMSFAELANTVARRSRLVATGLFGHVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUK9</accession>
    <name>A0A7D5UUK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g005890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058932">
        <property type="protein sequence ID" value="QLI66152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014549915.1">
        <property type="nucleotide sequence ID" value="XM_014694429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUK9"/>
    <dbReference type="GeneID" id="26239359"/>
    <dbReference type="KEGG" id="mbrn:26239359"/>
    <dbReference type="OrthoDB" id="3552888at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35605:SF1">
        <property type="entry name" value="ECP2 EFFECTOR PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029008048" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI66152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23373" checksum="53FEE2745D9F3884" modified="2021-02-10" version="1">MKFSVTSVVAAMLAVVNGLPSPPLAELDAFNVIGGVTWTGEVLPGKNVTFSGTMQEVRAKILAENPDYFSAYDNEAGIEHGSHLQKRWELKQPPDCNYGNFIRRINAIKFINELNAKGGGNAMCGAPPRRGPGLGGCSRVSCSWGSQMWLCNDNDYHLDLPCTEVASALFELSNVCYTVQQGGDTETQGQLFTTDNWNVIIDYYGDCHSSPTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUM9</accession>
    <name>A0A7D5UUM9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity nicotinic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TNA1_1</name>
        <name evidence="9" type="ORF">G6M90_00g049550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014545064.1">
        <property type="nucleotide sequence ID" value="XM_014689578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUM9"/>
    <dbReference type="GeneID" id="26242405"/>
    <dbReference type="KEGG" id="mbrn:26242405"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QLI67415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="483" mass="53755" checksum="39E823CD4E9073AF" modified="2021-02-10" version="1">MEKSEYASSHTERQTAVPSPQARRDIDDDEVYSLQEQKRIIRRIDFRLVTVLACLYIISLVDRVNISTAAVAHLNSDLALQTGARYSIVISVFFITYTVFQPLGTVLTRKIGPRLFLSSIAMAWGVVMIGNGFVHSWQTLAGLRVLIGVFEAGYFPGAVYLLSTWYTRFDMQKRYTVFYGVGCVAGALGGILAFGLSQMNGLAGLRGWRWIFIIEGVLSCVGALVSYVFLVGFPEEADQSWNFINRQERDFIIRRVNRDRGDAVTEPFSLGVFLAPAADFKIWIFAFIFFCVTTVGYSINFFLPMILLGMGFSVAESQCLIVPPWVFTGLLMYAQAWLGDRYRLRGPIIAFNAVLALVGLILMAFHHAYPVRYTGVFFVVAGASGNTPPVLTYQANNIRGHWKRAFCSATLVGFGGIGGIAGALVFRSQDQPRYLPGIYASIACNVCILLCTGGLSIWFWHANQQVKRGKVVLEGLEDFTYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UUX8</accession>
    <name>A0A7D5UUX8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metacaspase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">casA_1</name>
        <name evidence="7" type="ORF">G6M90_00g042920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986378.1">
        <property type="nucleotide sequence ID" value="XM_066130313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UUX8"/>
    <dbReference type="GeneID" id="26240189"/>
    <dbReference type="KEGG" id="mbrn:26240189"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="142"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI67438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="439" mass="47833" checksum="4DD28F7078E30CB5" modified="2021-02-10" version="1">MSAYPGYGGGGGYGPPQSSQYQGNYYRPQQGYGGYPPQGQPSPQPQPGYGYHQPHPAQPQYAYQHHGPPPPQQYAGHYSPAPPQPQPGYASRPGQSPGIPPPQHGAYSPRMSGPPVPPSGLQHFGAGAPQGYAFQYSNCTGRRKALLIGINYFGQRGQLRGCINDVRNMTAYLAEHFGYRREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDALFFHYSGHGGQTKDLDGDEADGYDEVIYPVDFRQTGHITDDEMHRIMVRPLQAGVRLTAIFDSCHSGTALDLPYIYSTQGILKEPNLAKEAGQGLLGVISSYSQGDLGGVASNIMSFFKKATSGEDAYARTLATKTSPADVIMLSGSKDDQTSADATIASQATGAMSWAFMTTLKKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLSTYHRIQAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVN6</accession>
    <name>A0A7D5UVN6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC multidrug transporter atrF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atrF_0</name>
        <name evidence="12" type="ORF">G6M90_00g040430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">4556</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547391.1">
        <property type="nucleotide sequence ID" value="XM_014691905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26239954"/>
    <dbReference type="KEGG" id="mbrn:26239954"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1292"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1324"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1444"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="160"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="843"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QLI68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1470" mass="164247" checksum="16523DD15881EC69" modified="2021-02-10" version="1">MAHHSAVGQSEAQKGRHAPTSRSQSPDSALTAGDNQSIGNHAAGVPYGVSVEQAEADFVQLQRELTGASRASRRRSAVKNIDPEKAAPVDSRGTDNESLFDLETVLRGSLAAEEAAGIKPKHIGVCWDGLTVKGIGGMANYVQTFPNAFINFFDVITPVINLLGLGKRPPEATLLDSFQGVCNPGEMVLVLGKPGSGCTTFLKTIANQRHGYTSVQGDVFYGPWTAKEFTRYRAEALYNAEDDIHHPTLTVEQTLGFALDTKMPAKRPANMTQDDFKEHVISTLLKMFNIEHTRKTVVGDHFVRGISGGERKRVSIAEMMISNACILSWDNSTRGLDASTALDFTRSLRILTNLYKTTTFVSLYQASENIYRLFDKVMVIDEGKQVYFGPANQARSYFEGLGFAPRPRQTTPDYLTGCTDEFERQYAPGCSENNSPHSPDTLREAFRKSNYQKKLESEIAEYKANLDQEKHKHNDFQIAVKESKRGASKRSVYQVGFHLQVWALMKRQFTLKLQDRFNLTLAWVRSIVIAIVLGTLYLNLEKTSASAFSKGGLLFVALLFNAFQAFSELASTMLGRAIVNKHKAYGYHRPSSLWISQILVDQAFAASEIMLFSIIVYFMSGLVRDAGAFFTFYLMILSGNIAMTLFFRIIGCASPDFDYAIKFAVVIITLFVTTSGYIIQYQSEKVWLRWIYWVNPLGLIFSSLMQNEFQRIDMTCTADSLIPSGPGYTDINHQVCTLPGSNAGTTFVAGPDYIAQGFSYYPGDLWRNWGIVLSIIIFFLILNVVLGEVVKFGMGGNSFKVYQRPNKERAALNEKLLEKREARRKDKSNEVGSDLSIKSESILTWENLNYNVPVPGGTRRLLNNVFGYVRPGELTALMGASGAGKTTLLDVLASRKNIGVITGDVLVDGFKPGKQFQRSTSYAEQLDLHEPTQTVREALRFSADLRQPYETPLAERHAYVEEIIALLEMEHIADCIIGTAEAGLTVEQRKRVTIGVELAAKPELLLFLDEPTSGLDSQSAFNIVRFLKKLAAAGQAILCTIHQPNAALFENFDRLLLLQRGGRTVYFGDIGEDAAILRAYLRRHGAEAAPTDNVAEFMLEAIGAGSSPRVGERDWADIWDESPELERAKKAIVEMREERKSVAQHANPDLEKEYASPVHHQIRIVVRRMFRAFWRTPNYLFTRLFSHFAVAFVSGLTYLNLDTSRSSLQYTVFVIFQVTVLPALIISQVEVMFHIKRALFFREASSKMYSPMTFATAIVAAEMPYSILCAVVFFVCLYFMPGLDPTPSRAGYQFFMVLITEVFAVTMGQGLASLTPSPRISAQFDPFIIIIFALFCGVTIPAPQMPGFWRAWLYQLDPFTRLIGGMVTTALHGLQVVCTSSELNRFTAPSNMTCGEYMTPFFERGAPGYLVSNDTQNCEYCAYKIGDEFYGRLNMSFDNRWRDLGIYIAFIGSNLIILFTASRFLNFNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVV2</accession>
    <name>A0A7D5UVV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">YGK1</name>
        <name evidence="14" type="ORF">G6M90_00g046390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">4556</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544765.1">
        <property type="nucleotide sequence ID" value="XM_014689279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVV2"/>
    <dbReference type="GeneID" id="26242106"/>
    <dbReference type="KEGG" id="mbrn:26242106"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="76"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QLI68078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="267" mass="30404" checksum="F689114F84D0DB85" modified="2021-02-10" version="1">MGSQADRKNSGKTDISNLGFTPMVKVSGEWEVEKVVDAIPGDAPKSGGQSPLAFFHMIERLKTTKREGWRRFGIERGESIADHMYRMSIISMFAPPSLAKRIDLHKCMKMCLIHDMAELLVGDITPVDGVPKPEKSRRESLTMHYLTKNLLGNKDDAAVGEDIRAIWDEYEDSKTLESQYVHDIDKMELLLQMMEYEKRAEGALDLGEFAYVSSKMVLDETKAWAKELIEEREKFWGTKQHVDGVKGVEGGVTEEKTKMQDEYYSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UVX8</accession>
    <name>A0A7D5UVX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C6 finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g038110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986529.1">
        <property type="nucleotide sequence ID" value="XM_066130233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UVX8"/>
    <dbReference type="GeneID" id="26239733"/>
    <dbReference type="KEGG" id="mbrn:26239733"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="104475" checksum="9B67052C1206C8A8" modified="2021-02-10" version="1">MPLTFPTPTIVYHHQYQRQHHHRRCICCLSVFVEHPRRFPQSHIQHAAWSAGSFCFTPGPSSSLLLIFASLHLLYQGLHERAVSPARLYNITASRNQSLLSISVSMTLDFNTNGGGEALINLNFDQHHRDQTAYAYSTTPATYPSPPTASGIMTNTRPWTFPVDMASSNPQATSTASPEDHQGSSPLSHASSPQSQHSPLQQSPFQPAANPLTDWALQQQQQRHQQAAAAHQQPQQPLPAQDLAQFIQDSALLGFNAFPQNFQPSPLDYLPPTTQAALQANLLESPFTSMPPMEETAHAMHWGSSGMDNWHDFQSTLQMDGLPRLDSVGSNSPTGTYLEVLSLPSSSGEGWAMVDWSHHGLDHFQQAQNAAIFNPGQTLHLRTNSDSSEGANSMEFGSFEEIPRFPYSPFSPESDGYADQNCNHNHRNCVAETRNHTLDTVSPTASVAPVATKVESSSSVRHSPGSGAGSVSPASTTTSRRNSGPRKSPITKTTTKTIIRRSSNGKKDGTVEKKVGRRKGPLLPEQRKQASEIRKLRACLRCKFLKKTCDKGEPCAGCQPSHARLWQVPCTRIDIKDIGYFMKDWKADYERHVDLGMSVYNVKGFSSKETLMWITHGYGFALPVMVREVYVADEGCFSVEWVESTVAHQDPIDFETRTEKLDVGAEGIRLDALQEYLDKHVDGPFEDFIDDHFEGTPFITEILKTAHRYYVKDRMPVIKKALKLVLAYNLTMHITMVENQGSEVTLDGQIDDEDSKFYGRTVAPVMINFQIKCALADMWRELQKDILEELSALYSGVYSGEKMKNWPTIFMLASILLAVWEEMQFDCHYRVPDPAAVNKFCHDMETTPVGVIVGLFHAISQKLPAFTDWDTRQHGHLLHNNVSVCEAMTEVRQHVIKHEAYLRTRKEQTKFDRYDFDSLSNKFLSKLVIRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW00</accession>
    <name>A0A7D5UW00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">G6M90_00g060700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">4556</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI68734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014544639.1">
        <property type="nucleotide sequence ID" value="XM_014689153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW00"/>
    <dbReference type="GeneID" id="26243051"/>
    <dbReference type="KEGG" id="mbrn:26243051"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="6">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QLI68734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="224" mass="25310" checksum="FF933B278D2645FE" modified="2021-02-10" version="1">MGEAEAAHAPSGDPRHAKYYFAYGSNLHMKQMQRRCPKSKYVGFGRLPNFRWQINERGYANVVYAEGHWVDGLVYEIEETDEEKLDISEGVSKGAYEKQHMQVRVKLACCSLYRRSVPWIVSRGGPCRVRKSAKHSHRKTTATIDRETDNVLVYISLVHVVDSSPKEEYIDRINRGLKDAASLGMDDDYIRNCIRPFVPESGGSSQETPTPTRSNSPRASEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UW89</accession>
    <name>A0A7D5UW89_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoaspartyl peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iaaA</name>
        <name evidence="4" type="ORF">G6M90_00g036060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014546999.1">
        <property type="nucleotide sequence ID" value="XM_014691513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UW89"/>
    <dbReference type="GeneID" id="26239562"/>
    <dbReference type="KEGG" id="mbrn:26239562"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="339"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QLI68530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="456" mass="49131" checksum="1CFB63B85EAB67EA" modified="2021-02-10" version="1">MQMQYEKQPPPSETRKTQPRIVIHGGAGNIVRANFPQDKYNAYRDALLAIITKTNQYITTPVKSSQKPSALDIACYAVRLLEDNPLFNSGHGAVFTRDGVNELEASVMVSRGREKRGVGVMGLRHVRNPVLLARGVLEHGDQDLAPRGQAPCAAAVAGHRLDVPSAQGHTQIWGPAAEQLARRYGLDMVDPSYFFTQQRWDEHVRALEREGRGRGQGTWSADEYLPQGTCGAVALDEDGVVCAATSTGGMTNKLTGRIGDTPVVGAGFWAEEWEESGAAGPSAWERLTAAVRAASPGISLAGPLKGLLADCFPTPFFYSPLREPHGETVVSRAMGASGTGNGDSFLRISAARTVAAMARWKPESTARALTNVVGPGGELQRSAGDRWGRTGEGEGGMIGIESIVERDAKSGQVVRVRSEIVMDYNCGGMYRAWVDDQGRARMSIWSNVGEDPENRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UWP2</accession>
    <name>A0A7D5UWP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">G6M90_00g039810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986548.1">
        <property type="nucleotide sequence ID" value="XM_066130260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UWP2"/>
    <dbReference type="GeneID" id="90967660"/>
    <dbReference type="KEGG" id="mbrn:90967660"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="112"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="QLI68273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="483" mass="56098" checksum="9E490D8E4D595398" modified="2021-02-10" version="1">MDEAGRWWRELWHDWPNAWDVCRRRGLLKALPDMARAAIWTVLMIVLFAGVIACDLLRTTWSHAYPLSGHNRDKRERRRKDNSLQRLLSRPMADPISAYRTVHSQSPQHDEKAKTSIFSRLPPEIRRHVLVSAFGERTLHMDLDFRLPFNLVEKKPYDGCDVHARIHQENLASDSHLDTKSGRNRTWRWFGCVCHRFDIVKTPPLTYGRRCNYRCAHFGEPDTDMCLRGSGKCNTWPGTWPVKCQIGVMGWMLSCKRAYFEVMDVLYSTNTFHIASPVLMKSMSDLFPSHILANIQSIELVWQPKDLPLVEGFCSRVKHSEYQHPVFPSLAYLRIAFARMVIHEVDHATDMIWPYDNRRLLSERLHNSFLPQMDELINRIAPPTAEVTVSCAKWDWYELIDVSLLESQGKEATRMQRADIEGLRCWRMIPIRRSISWEDAEAGLSSVPSREGYWIHIPIGDMVTIGNEMSFMVLGRTASHVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX08</accession>
    <name>A0A7D5UX08_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-lysergyl-peptide-synthetase subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lpsC</name>
        <name evidence="8" type="ORF">G6M90_00g054540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014540950.2">
        <property type="nucleotide sequence ID" value="XM_014685464.2"/>
    </dbReference>
    <dbReference type="GeneID" id="26246256"/>
    <dbReference type="KEGG" id="mbrn:26246256"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="812"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI69376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="1836" mass="202044" checksum="9F38A6368A51C4B0" modified="2021-02-10" version="1">MANEKAALEFWSSKLQAAEPCILTLSNRSTAAPSSSTIEAVTIDLEEIGNSWSEYFNVCNVSTSAILMTAWGMVLHTYTDSDEVCFGHTFTTRQKPVNGHDALNGPQVNILPFFLEFEGEATLLETVRKSQLDLADAQSNQDVSLAEICSHMGMETNALFNTCMLFSSDEQTPPDAAPDISSQEVTLMEGCPQYDIIIHVSSSKQCVLLYQSHYLSNDQAVHIAGALRVALTSIIDSPHLVTEKVEIFSPVDENKISQWNETAPVASESCLHDLINQQCDLHPDSLAVVAWDGSFTYGELDRLSNTLAQRLFLEGIGPDVFVAICADRCKWIPVAMLGIIKAGGAFCALDPSHPPSRLKEMCKALGSSMVITTADDAQKADELALTTIVLGDDSMTEPNGTKFSLERPSSSKTRPSHALYSVFTSGSSGNPKGVVIEHRSFASTALASLKPLNIRPEDRILHFASYAFDLSVFEVLTALTAGASVAIPSEKARMEFLPRAATELEATWTFLTPTVARMYRPSDFPTLRTISLGGELVQTSDIEFWASKNLITGYNPAECCPLGISGPANLSEANFLGWPFVSHAAWVVDTRDFQKLVPVGAIGELIIEGPAVARCYLHDKQNALPDSPFIISPPRWLTRFRGEASPDARLYRTGDLVRYGFNGAVHYIGRKDFQIKIRGQRVELGEIESQLRTAFSAGNHCVAVEAVKLSGWTTLVAFISMNSSDSVTNRDAAPTVRLQDITQELEIYVGGVATKLRGILPASMIPAAFLPVTHIPVSKSGKVDRKQLRALASSLSPEVLFRSKGESTSGNLPETDDERRLQALFAQVLGISPSNITADSDFFRLGGDSVQAMKLLALVSQEELFGLTYSDIFQHPRLRDMLNASRSRSSFIDSDDETVSTDSGLTPFCLVKDANTLIDIASDQCGINKGNIEDIYPCTSTQANIMASAAPDGDPCVSIRSFKLQHNIDKALVKQAWSITSQGHSILRTRIIQSKTGAFFQVVVREDICWSDYTDGDDSNSRFRPSFALGSPSVQLCFMKGRLYVAIHHALYDAWSLSRLLNEVDEAYCQLSVRQLPPLNRYVKHVAESLDSVASFWKAELEDAHPAHFPELPSNKANLETISTPTKSIGTTMPIDSERRSNVEYELQLAWAITCYSYTKNEDVIFGIVSSGRNIPLEGVDKMLGPIFGITPLRVPIDPAEEVAEAIEELQYRSEEQAAYTHLGLHRISQLGQTAAAACRFQTLLVVEPNESEIQGTWFCDHEIIYDSIEPRHHSLTLKCLVKPRFVDVTAIFHQSILPDAQKQDILLRFQHIFQQIHTSDAPDSTIMDIDTETPQNFDGIQHSSLFVKNVGSDYTTANQLHNRDIFLCNSPKSEINHSPSMVEHALEEVAQAQNSSCRTGTRLESQQLAQASEAVNLVAEIDRYDGTIAIAQQEELASAKRSSRADDLYFKPHAGMSITVFLTGSNGFIGTEVLRQLLENHNIRRVIALVRGSSAQEARSRTIDSAKKALWWTDGHGEKLDVWPGDLSLPHLGLDSEHWSILEDGTTVDAVIHNGASVHWLKSYAALEGTNVRSTAELLRIAVKTPHVRFTYVSSGRYQDPVEEVEEQVAMQFAAGGIPYSQTKFVAESLVRRAAARIPSRLSNLAVASLGLVIGTPTEGVVNSDDYIWRLVAACIKAGVCNADELDKWFPVSDVARTASIIVDTVLEPVTTSAPVKQVTGGITWREIWDIVTEMGYTIESRPAMDWMRAIRQDIEVEREHHPLWTLAQMIEGSIDNKEPMWAASWCGNQAASVRLKGAVKHSIQFLGEIGFIPKSGLKVQEQVHKIHRGAFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX13</accession>
    <name>A0A7D5UX13_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagZ_0</name>
        <name evidence="8" type="ORF">G6M90_00g038650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI67752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014547221.2">
        <property type="nucleotide sequence ID" value="XM_014691735.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX13"/>
    <dbReference type="GeneID" id="26239784"/>
    <dbReference type="KEGG" id="mbrn:26239784"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QLI67752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="939" mass="102305" checksum="4A90494A83BF4AB5" modified="2021-02-10" version="1">MAAANLNPKKPNSSSSSDGSDLDPLWQNLDWAVGQMLIMGWDGTEVTPQIKSLIEDHHLGSIILTAKNLKSAQETAKLVQELQTIAKNAGHPQPLLIAVDQENGGVNSLFDEDYVCQFPSAMGIAATGRVELAYEIYKATASEISACGVNLMLGPVLDVLNNARYQPLGVRSTGDDPQEASQYGLAALNGIRDAGIAAAGKHFPSYGNLDFQGSNSAVPVITQTLEELSLSALVPFRNAIATGKLDAMFVGGCGISNPSMNVGHACLSDQVVDDLLRNELGFKGVAISECLEMEALSHDLGVQNGVVMAVEAGCDLVLLCRAYDVQLEAIKGLKLGYENGIITKDRIFTSIRRVQHLKSTCTSWAKALNPPGISLLSQLHPSHVSLSRRAYDESITVIRDKEKMLPLSSSMHPGEELLLLTPLVKPLPASAMTKSLLESKKTWSQAPTQHDSWAHKDRERSAIMSGEGVFREFGKNLARYRNEKLLHTSYTANGVRPVHENLIARASCIIIVTADANRNMYQAGFTKHVDMMCSMHRSRGNKKQLIVVAVSSPYDFAMDKSIGTYICTFDFTEDAMSALVRVLVGEITPIGSMPGTLRKSKKVLKSRQHWLVEEYDRARDYAGLEDLLKAVHRASAPDLHFLKSTRAASMELHLPNIKESHFVVRNSSTGALYGFVATYFIAGVGIIGALLVDPSKRNVSIGRSLHRRALKSLSQQRGLKKVQVGMSFPGVFLGIPLDPEANTVKEWFSNSGWDTQFPRRLTNMIIHDLPNWVAPEGLLQSIQRANISFDLIHGLENAESVLHHVRANANPEVLELYTYALSENKTCGIVRAKDPSGNLIGTVIICRQGSPLVTYIPPLLSDREDVGGIIAPIVPSTPQATLVLQGLALMGVRQSKGHRASKAVLSWIVDDAFEPLVAMGFDILQAFEEITNSPEVCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UX82</accession>
    <name>A0A7D5UX82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">G6M90_00g030470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">4556</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP058933">
        <property type="protein sequence ID" value="QLI68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_065986610.1">
        <property type="nucleotide sequence ID" value="XM_066130060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UX82"/>
    <dbReference type="GeneID" id="90967576"/>
    <dbReference type="KEGG" id="mbrn:90967576"/>
    <dbReference type="OrthoDB" id="5026622at2759"/>
    <dbReference type="Proteomes" id="UP000510686">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="QLI68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000510686"/>
        </source>
    </evidence>
    <sequence length="114" mass="12448" checksum="97A96D3F7F619EA8" modified="2021-02-10" version="1">MDSDREMDAAEETDPTLRPTHRLKDIKAGDYSVQLLVSTKDHVYDAENVEAGTSSWQVIGAWDESSVPELSKFLNSRQTTASRDPTGSTTTFGTRYGGGFTLGPQKSDNESSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-02-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D5UXD9</accession>
    <name>A0A7D5UXD9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">G6M90_00g061050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Metarhizium brunneum</name>
        <dbReference type="NCBI Taxonomy" id="500148"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Clavicipitaceae</taxon>
            <taxon>Metarhizium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2020-07" db="EMBL/GenBank/DDBJ databases">
            <title>Telomere length de novo assembly of all 7 chromosomes of the fungus, Metarhizium brunneum, using a novel assembly pipeline.</title>
            <authorList>
                <person name="Saud z."/>
                <person name="Kortsinoglou A."/>
                <person name="Kouvelis V.N."/>
                <person name="Butt T.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">4556</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP058934">
        <property type="protein sequence ID" value="QLI69614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_014542763.1">
        <property type="nucleotide sequence ID" value="XM_014687277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D5UXD9"/>
    <dbReference type="GeneID" id="26244712"/>
    <dbReference type="KEGG" id="mbrn:26244712"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Pr
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